miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7c-5p ABCB9 -1.70744661345097 2.87934212005942e-20 1.00955603859492 1.63896842371547e-09 MirTarget -0.273859383833607 6.80741103254938e-11 NA NA NA hsa-let-7c-5p ABCC10 -1.70744661345097 2.87934212005942e-20 1.42399346571582 1.7634577339245e-36 MirTarget -0.301575187605271 5.72062761788124e-25 NA NA NA hsa-let-7c-5p ANKRD49 -1.70744661345097 2.87934212005942e-20 0.399680304237402 6.46826622613075e-08 MirTarget -0.100989362644086 4.78554482063786e-08 NA NA NA hsa-let-7c-5p BZW2 -1.70744661345097 2.87934212005942e-20 0.577245550489843 7.10575922293368e-08 MirTarget -0.203335965765395 1.43522953010322e-14 NA NA NA hsa-let-7c-5p CBX5 -1.70744661345097 2.87934212005942e-20 0.352720475583158 0.00158496538783418 MirTarget -0.117320573000309 2.65277493570271e-05 NA NA NA hsa-let-7c-5p CBX6 -1.70744661345097 2.87934212005942e-20 -0.135925898836227 0.562356772831778 miRNAWalker2_validate -0.147751255324137 0.0120748662714877 NA NA NA hsa-let-7a-5p CCNB2 -0.328069937201898 0.000464344093744051 4.23615330954301 1.17296327500891e-51 miRNAWalker2_validate -0.449095168142698 0.00713886337518027 NA NA NA hsa-let-7b-5p CCNB2 -0.959013717270803 5.95127281258643e-11 4.23615330954301 1.17296327500891e-51 miRNAWalker2_validate -0.589177166241791 8.39990492744342e-09 NA NA NA hsa-let-7c-5p CCNB2 -1.70744661345097 2.87934212005942e-20 4.23615330954301 1.17296327500891e-51 miRNAWalker2_validate -0.85447689630769 1.64053136609545e-30 NA NA NA hsa-miR-23b-3p CCNB2 -0.530561587109023 5.43807206823652e-07 4.23615330954301 1.17296327500891e-51 miRNAWalker2_validate -0.641555640172717 9.69421048739327e-06 NA NA NA hsa-let-7b-3p CCNE2 -1.21979213547786 5.84575581584603e-17 2.01834184083791 5.42527234853282e-21 mirMAP -0.268569886454063 0.000212358107274223 NA NA NA hsa-miR-126-3p CCNE2 -0.652349350198172 9.37876280344772e-09 2.01834184083791 5.42527234853282e-21 miRNAWalker2_validate -0.385200741422764 5.31716743581417e-05 NA NA NA hsa-miR-26a-5p CCNE2 -0.963792031426845 1.83360999387345e-22 2.01834184083791 5.42527234853282e-21 miRNAWalker2_validate;miRTarBase;miRNATAP -0.488121351666366 3.8244940657208e-06 24116110;21901171 The loss of miR 26a mediated post transcriptional regulation of cyclin E2 in pancreatic cancer cell proliferation and decreased patient survival; The in vitro and in vivo assays showed that overexpression of miR-26a resulted in cell cycle arrest inhibited cell proliferation and decreased tumor growth which was associated with cyclin E2 downregulation;We also show that enforced expression of miR-26a in AML cells is able to inhibit cell cycle progression by downregulating cyclin E2 expression poor survival;progression pancreatic cancer;acute myeloid leukemia hsa-miR-26b-5p CCNE2 -1.10804856399744 4.14176110314282e-22 2.01834184083791 5.42527234853282e-21 miRNATAP -0.579195472860141 1.12131120131545e-10 NA NA NA hsa-miR-30a-5p CCNE2 -0.626257932887855 0.000108198196973765 2.01834184083791 5.42527234853282e-21 miRNATAP -0.356376866932366 9.6729026873686e-08 NA NA NA hsa-miR-30c-5p CCNE2 -0.432111642767632 0.000159764714931007 2.01834184083791 5.42527234853282e-21 miRNATAP -0.190760531928298 0.0478037459406433 NA NA NA hsa-let-7c-5p CCNF -1.70744661345097 2.87934212005942e-20 2.17480980282222 4.71512834823536e-34 miRNAWalker2_validate;MirTarget -0.504449149504788 2.14481709469935e-28 NA NA NA hsa-let-7c-5p CDC25A -1.70744661345097 2.87934212005942e-20 1.92057841155944 2.96621670231863e-18 MirTarget -0.51524439141821 8.99192957021977e-21 25909324 MicroRNA let 7c Inhibits Cell Proliferation and Induces Cell Cycle Arrest by Targeting CDC25A in Human Hepatocellular Carcinoma; The aim of the present study was to determine whether the cell cycle regulator CDC25A is involved in the antitumor effect of let-7c in HCC; The luciferase reporter assay showed that CDC25A was a direct target of let-7c and that let-7c inhibited the expression of CDC25A protein by directly targeting its 3' UTR; In conclusion this study indicates that let-7c suppresses HCC progression possibly by directly targeting the cell cycle regulator CDC25A and indirectly affecting its downstream target molecules progression liver cancer hsa-miR-122-5p CDK4 -1.23907441373955 4.42181244888642e-06 0.667631464196621 2.00897661385551e-11 miRNAWalker2_validate -0.116994239033144 4.65868213756134e-11 NA NA NA hsa-miR-145-5p CDK4 -1.4795885711477 6.47308361543414e-16 0.667631464196621 2.00897661385551e-11 miRNAWalker2_validate;miRTarBase -0.153089865179612 2.59222750442516e-09 21092188 Furthermore we found that CDK4 was regulated by miR-145 in cell cycle control lung squamous cell cancer hsa-miR-193b-3p CDK4 -0.166697207281748 0.272022543069482 0.667631464196621 2.00897661385551e-11 miRNAWalker2_validate -0.152018771778108 2.97527104247713e-06 NA NA NA hsa-miR-195-5p CDK4 -1.85907534356434 1.47434041676402e-22 0.667631464196621 2.00897661385551e-11 miRNAWalker2_validate;miRTarBase -0.181976803431634 3.34979886785679e-14 NA NA NA hsa-let-7c-5p CECR6 -1.70744661345097 2.87934212005942e-20 0.392226039618319 0.0399877472539567 MirTarget -0.145473456803039 0.00240190908970139 NA NA NA hsa-let-7c-5p CEP135 -1.70744661345097 2.87934212005942e-20 0.275453361086419 0.0378107269841227 MirTarget -0.128226314386056 0.000108910151993848 NA NA NA hsa-let-7c-5p CERCAM -1.70744661345097 2.87934212005942e-20 -0.11834200381201 0.648161793551643 MirTarget -0.138379572621477 0.0336460392243724 NA NA NA hsa-let-7c-5p CNOT3 -1.70744661345097 2.87934212005942e-20 0.579019484348105 2.78881715385032e-17 miRNAWalker2_validate -0.137147538185394 1.56310657094192e-15 NA NA NA hsa-let-7c-5p COL24A1 -1.70744661345097 2.87934212005942e-20 2.07152152023539 2.94685578585709e-08 MirTarget -0.322074263479633 0.000715997285583281 NA NA NA hsa-miR-148a-5p CSNK1E -0.767626696027761 1.08359477494797e-06 0.608336779934033 9.56780795613581e-12 miRNATAP -0.245152102120518 4.84178312131527e-20 NA NA NA hsa-miR-195-3p CSNK1E -1.09375690196245 4.70092324819807e-09 0.608336779934033 9.56780795613581e-12 miRNATAP -0.104078083921822 9.86380539775099e-06 NA NA NA hsa-let-7c-5p CSNK2A1 -1.70744661345097 2.87934212005942e-20 0.311613292322925 6.17228757339028e-05 miRNAWalker2_validate -0.118081213291704 8.22763425873157e-10 NA NA NA hsa-let-7c-5p CYB561D1 -1.70744661345097 2.87934212005942e-20 1.35618855619484 4.53684308721849e-24 MirTarget -0.301970204704956 9.88527966067797e-19 NA NA NA hsa-let-7c-5p DAGLA -1.70744661345097 2.87934212005942e-20 1.16197262256378 7.56867119602314e-06 MirTarget -0.448159334629883 3.0762615596391e-12 NA NA NA hsa-let-7c-5p DCAF15 -1.70744661345097 2.87934212005942e-20 0.442903624361357 6.04251738050238e-08 MirTarget -0.101335020598812 8.14528075667905e-07 NA NA NA hsa-let-7c-5p DCLRE1B -1.70744661345097 2.87934212005942e-20 0.715031438649862 1.3174682860474e-13 MirTarget -0.114154467810837 3.88086854753268e-06 NA NA NA hsa-let-7c-5p DCTN5 -1.70744661345097 2.87934212005942e-20 0.109069264850494 0.145747375920191 miRNAWalker2_validate -0.137050765086275 4.53587636121251e-14 NA NA NA hsa-let-7c-5p DLGAP4 -1.70744661345097 2.87934212005942e-20 0.616384781844966 4.24155614328603e-13 MirTarget -0.178146649866821 2.96101504576869e-17 NA NA NA hsa-let-7c-5p DNAJC6 -1.70744661345097 2.87934212005942e-20 2.31761593888368 5.40782208875271e-21 miRNAWalker2_validate -0.383639320555159 2.04522452132374e-09 NA NA NA hsa-let-7c-5p DOT1L -1.70744661345097 2.87934212005942e-20 0.585703387018246 2.71031330751421e-07 miRNAWalker2_validate -0.149931329292625 1.58114052310453e-07 NA NA NA hsa-let-7c-5p DZIP1L -1.70744661345097 2.87934212005942e-20 -0.0817102374066513 0.728597088782924 MirTarget -0.153365860262585 0.00940939013868638 NA NA NA hsa-let-7c-5p E2F2 -1.70744661345097 2.87934212005942e-20 2.82262179260901 6.90997126839698e-33 MirTarget -0.605641654221748 3.1290897462579e-23 NA NA NA hsa-let-7c-5p E2F5 -1.70744661345097 2.87934212005942e-20 0.730554652437087 0.000401890915871585 MirTarget -0.228095461415917 1.04748751614991e-05 NA NA NA hsa-let-7c-5p ELF4 -1.70744661345097 2.87934212005942e-20 -0.129534848954421 0.489734019401336 MirTarget -0.135890153838811 0.0038215332500121 NA NA NA hsa-let-7c-5p ESPL1 -1.70744661345097 2.87934212005942e-20 1.87757313624794 3.45937181689806e-13 MirTarget -0.45417008213531 3.14084416633658e-12 NA NA NA hsa-let-7c-5p FAM103A1 -1.70744661345097 2.87934212005942e-20 0.489844961593656 1.4777880039426e-09 miRNAWalker2_validate -0.146424524120768 3.23230414839587e-13 NA NA NA hsa-let-7c-5p FAM104A -1.70744661345097 2.87934212005942e-20 0.382548867340036 2.14628142056169e-09 MirTarget -0.10225823892978 1.28559987604419e-10 NA NA NA hsa-let-7c-5p FANCI -1.70744661345097 2.87934212005942e-20 2.58883645204084 1.64497704333454e-42 miRNAWalker2_validate -0.553264627084958 3.44910425383123e-29 NA NA NA hsa-let-7a-3p FBXO32 -0.568717557554068 1.00947202557819e-07 1.49973264070402 1.35888111194844e-11 mirMAP -0.38916471208738 0.000151658861853164 NA NA NA hsa-let-7a-5p FBXO32 -0.328069937201898 0.000464344093744051 1.49973264070402 1.35888111194844e-11 TargetScan;miRNATAP -0.408608217233986 0.000583968456002134 NA NA NA hsa-let-7b-3p FBXO32 -1.21979213547786 5.84575581584603e-17 1.49973264070402 1.35888111194844e-11 mirMAP -0.20693354019583 0.00476775913146388 NA NA NA hsa-let-7b-5p FBXO32 -0.959013717270803 5.95127281258643e-11 1.49973264070402 1.35888111194844e-11 miRNATAP -0.3485130972578 2.09750759880799e-06 NA NA NA hsa-miR-101-3p FBXO32 -1.48176407980989 3.98950707385704e-31 1.49973264070402 1.35888111194844e-11 miRNATAP -0.457433236880843 8.98934153612009e-09 NA NA NA hsa-miR-139-5p FBXO32 -2.11299531796557 8.16407076415038e-28 1.49973264070402 1.35888111194844e-11 miRanda -0.248867014578252 2.84390884190769e-06 NA NA NA hsa-miR-144-3p FBXO32 -2.97536914478815 6.00546047309683e-28 1.49973264070402 1.35888111194844e-11 miRNATAP -0.123870260990645 0.00112473386271035 NA NA NA hsa-miR-192-3p FBXO32 -0.6401165114007 0.000266272092403814 1.49973264070402 1.35888111194844e-11 mirMAP -0.416011661149065 1.26508248581647e-11 NA NA NA hsa-miR-19a-3p FBXO32 1.01712596153672 2.57753201450625e-07 1.49973264070402 1.35888111194844e-11 miRNATAP -0.168246835317001 0.0023625887932764 NA NA NA hsa-miR-19b-3p FBXO32 0.601279551368824 0.00016685097085251 1.49973264070402 1.35888111194844e-11 miRNATAP -0.23913099726224 0.000520544202177325 NA NA NA hsa-miR-23b-3p FBXO32 -0.530561587109023 5.43807206823652e-07 1.49973264070402 1.35888111194844e-11 miRNATAP -0.328405111949567 0.00160688452755544 NA NA NA hsa-miR-26a-2-3p FBXO32 -0.552429521617 7.7322049253051e-05 1.49973264070402 1.35888111194844e-11 mirMAP -0.333247401763822 2.260919464156e-05 NA NA NA hsa-miR-26a-5p FBXO32 -0.963792031426845 1.83360999387345e-22 1.49973264070402 1.35888111194844e-11 mirMAP -0.749573981541152 7.62418790634323e-13 NA NA NA hsa-miR-26b-5p FBXO32 -1.10804856399744 4.14176110314282e-22 1.49973264070402 1.35888111194844e-11 mirMAP -0.606502689591703 1.86714840609046e-11 NA NA NA hsa-miR-27b-3p FBXO32 -0.823491817819754 9.20935302746823e-14 1.49973264070402 1.35888111194844e-11 miRNATAP -0.516688019767081 9.38353902752944e-08 NA NA NA hsa-miR-3170 FBXO32 -0.490667754008914 0.0102869987033346 1.49973264070402 1.35888111194844e-11 mirMAP -0.215940283160539 0.00023072043114614 NA NA NA hsa-miR-320a FBXO32 0.325285936317332 0.0221415065838824 1.49973264070402 1.35888111194844e-11 mirMAP -0.166037304867455 0.0339564133821316 NA NA NA hsa-miR-335-3p FBXO32 -0.275199247483111 0.106629165248783 1.49973264070402 1.35888111194844e-11 mirMAP -0.4095666127518 1.39124567217462e-10 NA NA NA hsa-miR-33a-3p FBXO32 -0.683025859637737 1.01106097756419e-05 1.49973264070402 1.35888111194844e-11 mirMAP -0.251503190503819 0.000398106613167281 NA NA NA hsa-miR-33a-5p FBXO32 -0.767474460958522 1.09948756118522e-05 1.49973264070402 1.35888111194844e-11 mirMAP -0.138776931626495 0.0278057790087512 NA NA NA hsa-miR-369-3p FBXO32 -0.680843625018478 0.0155063508282041 1.49973264070402 1.35888111194844e-11 mirMAP -0.111599478190871 0.00454380231866122 NA NA NA hsa-miR-450b-5p FBXO32 -1.34333360369432 2.68386079790462e-17 1.49973264070402 1.35888111194844e-11 mirMAP -0.269009276779683 5.72016259812758e-05 NA NA NA hsa-miR-455-3p FBXO32 -1.3998033821095 5.72010709806871e-17 1.49973264070402 1.35888111194844e-11 mirMAP -0.352227247366592 2.18536409018519e-08 NA NA NA hsa-miR-590-3p FBXO32 -0.473167498047808 1.76652934637227e-05 1.49973264070402 1.35888111194844e-11 mirMAP -0.361384615984933 0.000307325389584702 NA NA NA hsa-miR-628-5p FBXO32 -0.714131904567584 3.9911900261429e-08 1.49973264070402 1.35888111194844e-11 miRNATAP -0.471220079072473 1.40207611609196e-08 NA NA NA hsa-miR-654-3p FBXO32 -1.72200544726291 6.91948971554614e-10 1.49973264070402 1.35888111194844e-11 mirMAP -0.139656043310257 0.00030923145150098 NA NA NA hsa-let-7c-5p FIGNL2 -1.70744661345097 2.87934212005942e-20 1.38863525177439 4.36348606427085e-07 MirTarget -0.440097760520244 1.38345498901364e-10 NA NA NA hsa-let-7c-5p FKBP10 -1.70744661345097 2.87934212005942e-20 0.164171258069953 0.48719948726372 miRNAWalker2_validate -0.199648875231396 0.00073149848136377 NA NA NA hsa-let-7c-5p GARS -1.70744661345097 2.87934212005942e-20 0.53606930447414 1.66438816977997e-09 miRNAWalker2_validate -0.161680244524281 2.42584352025334e-13 NA NA NA hsa-let-7c-5p GGA3 -1.70744661345097 2.87934212005942e-20 0.711679336404982 1.46861146142528e-21 MirTarget -0.172818653690179 3.02949988341581e-20 NA NA NA hsa-let-7c-5p GRPEL2 -1.70744661345097 2.87934212005942e-20 0.65712951992937 1.31065567027786e-19 MirTarget -0.166885706843202 3.33866025922138e-20 NA NA NA hsa-let-7c-5p GSK3A -1.70744661345097 2.87934212005942e-20 0.346560250550711 1.83266290443851e-08 miRNAWalker2_validate -0.101608466684152 2.71277295275603e-11 NA NA NA hsa-let-7c-5p HIF1AN -1.70744661345097 2.87934212005942e-20 0.594006229178836 2.59789157148843e-12 MirTarget -0.147609310389359 4.12097290603693e-12 NA NA NA hsa-let-7c-5p HMGA1 -1.70744661345097 2.87934212005942e-20 1.52957485940098 1.79164981120061e-17 MirTarget -0.517651637702838 1.10830470288536e-32 NA NA NA hsa-let-7c-5p HMGA2 -1.70744661345097 2.87934212005942e-20 1.11519648679255 0.015940340984894 miRNAWalker2_validate;miRTarBase;MirTarget -0.682135030438129 2.57681307834063e-09 NA NA NA hsa-let-7a-2-3p HOMER1 -1.19254913456912 1.47840144520517e-08 -0.0763641412081514 0.796151529043688 MirTarget -0.253281287503719 0.000175917559555184 NA NA NA hsa-miR-139-5p HOMER1 -2.11299531796557 8.16407076415038e-28 -0.0763641412081514 0.796151529043688 miRanda -0.267156507727504 0.000114980968432196 NA NA NA hsa-miR-148a-3p HOMER1 -0.748702855596996 3.93313343865641e-07 -0.0763641412081514 0.796151529043688 MirTarget -0.666575262467855 1.35873064627191e-12 NA NA NA hsa-miR-22-3p HOMER1 -0.628561621952407 1.33755558015523e-09 -0.0763641412081514 0.796151529043688 MirTarget -0.523755417860633 0.000127608919369781 NA NA NA hsa-miR-30c-1-3p HOMER1 -1.39373825444537 6.39912952911454e-17 -0.0763641412081514 0.796151529043688 MirTarget -0.187593390524113 0.0262223775681616 NA NA NA hsa-miR-30c-2-3p HOMER1 -1.39811819128587 3.66376924527665e-15 -0.0763641412081514 0.796151529043688 MirTarget -0.194705750340817 0.0129304241676584 NA NA NA hsa-miR-374a-5p HOMER1 0.016390363747302 0.869784217438621 -0.0763641412081514 0.796151529043688 MirTarget -0.417893362731193 0.00411476681675461 NA NA NA hsa-miR-374b-5p HOMER1 -0.307538028546424 0.0030079617545972 -0.0763641412081514 0.796151529043688 MirTarget;mirMAP -0.303566368791152 0.0300109000858296 NA NA NA hsa-miR-548b-3p HOMER1 -0.0203576084717134 0.930819503166956 -0.0763641412081514 0.796151529043688 PITA -0.338054258669289 3.73274922664469e-08 NA NA NA hsa-miR-30c-5p HSP90AA1 -0.432111642767632 0.000159764714931007 0.358140551368157 9.85322237128818e-05 miRNAWalker2_validate -0.202157986427488 1.9883621574863e-07 NA NA NA hsa-miR-30e-5p HSP90AA1 -0.627815042856657 3.02205690184908e-10 0.358140551368157 9.85322237128818e-05 miRNAWalker2_validate -0.241505661403756 4.10597516818342e-08 NA NA NA hsa-let-7c-5p IGDCC3 -1.70744661345097 2.87934212005942e-20 1.93021594033306 4.85774469918296e-06 MirTarget -0.631731378965707 2.0749328122547e-09 NA NA NA hsa-let-7c-5p IGDCC4 -1.70744661345097 2.87934212005942e-20 1.73062068710294 1.15353341113415e-06 MirTarget -0.669489234913257 2.47646431218122e-14 NA NA NA hsa-let-7c-5p IGF2BP1 -1.70744661345097 2.87934212005942e-20 4.99826974747196 9.59227871105866e-16 MirTarget -1.64306107284158 3.32791048956517e-27 NA NA NA hsa-let-7c-5p IGF2BP2 -1.70744661345097 2.87934212005942e-20 1.1359757160287 0.0039471483972338 MirTarget -0.66967665441044 5.02308301505737e-12 NA NA NA hsa-let-7c-5p IGF2BP3 -1.70744661345097 2.87934212005942e-20 2.42884018072337 1.74029814218083e-12 MirTarget -0.792505127678787 9.55879338832913e-21 NA NA NA hsa-let-7c-5p IP6K1 -1.70744661345097 2.87934212005942e-20 0.889516693961123 4.04556190796781e-31 miRNAWalker2_validate -0.136554103095589 1.44616222053653e-11 NA NA NA hsa-miR-192-5p ITGAV -0.50188499512787 0.00344713341196035 0.42083458357731 0.00760476174317356 miRNAWalker2_validate;MirTarget -0.344370980466671 1.89013250176103e-15 NA NA NA hsa-miR-32-5p ITGAV 0.0806126674664016 0.548984992497432 0.42083458357731 0.00760476174317356 miRNAWalker2_validate;MirTarget;miRNATAP -0.274975166498264 1.42681810268729e-06 NA NA NA hsa-miR-328-3p ITGAV -0.547466865311955 6.8359574451572e-06 0.42083458357731 0.00760476174317356 MirTarget -0.132063082039302 0.0363785445433637 NA NA NA hsa-miR-33a-3p ITGAV -0.683025859637737 1.01106097756419e-05 0.42083458357731 0.00760476174317356 MirTarget -0.155984185219414 0.00158654023964867 NA NA NA hsa-miR-374a-5p ITGAV 0.016390363747302 0.869784217438621 0.42083458357731 0.00760476174317356 mirMAP -0.174068026833335 0.0257907946480254 NA NA NA hsa-miR-92a-3p ITGAV 0.212391012518195 0.134292268089997 0.42083458357731 0.00760476174317356 MirTarget;miRNATAP -0.257814482101981 1.80305424957411e-06 NA NA NA hsa-let-7c-5p KCTD17 -1.70744661345097 2.87934212005942e-20 0.903379904615084 0.000443017892119058 MirTarget -0.481480851735286 2.15992968805401e-14 NA NA NA hsa-let-7c-5p KIAA1429 -1.70744661345097 2.87934212005942e-20 0.529087998279843 4.72515528254996e-10 MirTarget -0.12056072911504 1.72477615472835e-08 NA NA NA hsa-let-7c-5p KLHL31 -1.70744661345097 2.87934212005942e-20 1.26597140369387 1.58519014245934e-11 MirTarget -0.113451025803371 0.019099409616493 NA NA NA hsa-let-7c-5p LBR -1.70744661345097 2.87934212005942e-20 0.388685096070557 0.000119421752361692 MirTarget -0.180026392917426 3.89595826197494e-13 NA NA NA hsa-let-7c-5p LIMD2 -1.70744661345097 2.87934212005942e-20 -0.214037676050721 0.282021903246009 MirTarget -0.218360777157729 1.04445562421957e-05 NA NA NA hsa-let-7c-5p LIMK2 -1.70744661345097 2.87934212005942e-20 0.891712220823075 3.4499668982677e-09 MirTarget -0.236593103071651 4.17089447540952e-10 NA NA NA hsa-let-7c-5p LIN28B -1.70744661345097 2.87934212005942e-20 2.26854994708754 4.69141976850235e-05 MirTarget -0.942677952234562 8.19224435516587e-12 NA NA NA hsa-let-7c-5p MDFI -1.70744661345097 2.87934212005942e-20 1.613063811487 1.62996375672374e-07 MirTarget -0.449944709746608 5.78696252416618e-09 NA NA NA hsa-let-7c-5p MDM4 -1.70744661345097 2.87934212005942e-20 0.73357660128009 1.75853291398166e-12 MirTarget -0.16378523997819 4.65469630843185e-10 NA NA NA hsa-let-7c-5p MGAT4A -1.70744661345097 2.87934212005942e-20 0.104155687943847 0.347191347682603 MirTarget -0.139105957783091 3.9224788202799e-07 NA NA NA hsa-let-7c-5p NAP1L1 -1.70744661345097 2.87934212005942e-20 0.48873822323481 4.44413744556636e-06 MirTarget -0.248793874030014 2.70783118256391e-22 NA NA NA hsa-let-7c-5p NME6 -1.70744661345097 2.87934212005942e-20 0.606950484577572 4.34851975188018e-13 MirTarget -0.214598920327561 3.81766152781017e-26 NA NA NA hsa-let-7c-5p NPTX1 -1.70744661345097 2.87934212005942e-20 0.929025880461533 0.00584289763512414 miRNAWalker2_validate -0.349636575478964 3.44078587361936e-05 NA NA NA hsa-let-7c-5p NRARP -1.70744661345097 2.87934212005942e-20 0.806873954048561 5.97890763868229e-07 MirTarget -0.111854005713575 0.00649160992703926 NA NA NA hsa-let-7b-5p NRAS -0.959013717270803 5.95127281258643e-11 0.301156333096785 0.000285671613438218 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.105903409272711 8.57245668973746e-05 20607356 Transfection of let-7 miRNA reduced expression of pan-RAS N-RAS and K-RAS in the glioblastoma cells glioblastoma hsa-miR-126-5p NRAS -0.428561469405594 6.6035585844222e-05 0.301156333096785 0.000285671613438218 mirMAP -0.145651073417946 0.000106824688349933 NA NA NA hsa-miR-145-5p NRAS -1.4795885711477 6.47308361543414e-16 0.301156333096785 0.000285671613438218 miRNAWalker2_validate;MirTarget;miRNATAP -0.120395847533196 1.03194548202048e-08 26973415 miR-145 expression was significantly downregulated in colon cancer tissues with its expression in normal colonic tissues being 4-5-fold higher two sample t test P < 0.05 whereas N-ras expression showed the opposite trend colon cancer hsa-miR-22-3p NRAS -0.628561621952407 1.33755558015523e-09 0.301156333096785 0.000285671613438218 MirTarget;miRNATAP -0.287363482934569 1.84836871548684e-14 NA NA NA hsa-miR-29a-3p NRAS -0.856762511178136 4.65330336378459e-12 0.301156333096785 0.000285671613438218 miRNATAP -0.111209986118726 0.000497462508043792 NA NA NA hsa-miR-29b-3p NRAS -0.348885528720517 0.0121441341291285 0.301156333096785 0.000285671613438218 miRNATAP -0.163441778679427 1.31476396622707e-08 NA NA NA hsa-miR-29c-3p NRAS -1.4367517608807 1.61767774905781e-21 0.301156333096785 0.000285671613438218 miRNATAP -0.195416271463693 3.04370398757482e-15 NA NA NA hsa-miR-664a-3p NRAS 0.485807855553031 0.000732553249798598 0.301156333096785 0.000285671613438218 MirTarget -0.123577371649095 9.58480979576424e-06 NA NA NA hsa-let-7c-5p PAG1 -1.70744661345097 2.87934212005942e-20 -0.0641776217701535 0.737132600565642 MirTarget -0.11049170694399 0.0212818061791696 NA NA NA hsa-let-7c-5p PAK4 -1.70744661345097 2.87934212005942e-20 0.332066945941027 0.000554855795687645 miRNAWalker2_validate -0.146202847790971 7.66415471826461e-10 NA NA NA hsa-let-7c-5p PARD6B -1.70744661345097 2.87934212005942e-20 -0.0933903062942685 0.430333811242109 MirTarget -0.142218447562304 1.26822558335396e-06 NA NA NA hsa-let-7c-5p PCGF3 -1.70744661345097 2.87934212005942e-20 0.167536921370584 0.0398744101142924 miRNAWalker2_validate;MirTarget -0.113853768613945 1.4497220623856e-08 NA NA NA hsa-let-7c-5p PLAGL2 -1.70744661345097 2.87934212005942e-20 0.336986331692996 0.00300478705110513 MirTarget -0.167081915992385 2.69511671900005e-09 NA NA NA hsa-let-7c-5p PLEKHG6 -1.70744661345097 2.87934212005942e-20 0.0255008978984725 0.925472142399852 MirTarget -0.203069992909591 0.0029441217881029 NA NA NA hsa-let-7c-5p PLXND1 -1.70744661345097 2.87934212005942e-20 0.69765536803745 4.01395417482674e-09 MirTarget -0.121343527002517 5.62640054248759e-05 NA NA NA hsa-let-7c-5p PRAF2 -1.70744661345097 2.87934212005942e-20 0.470949457085433 4.21533714109916e-05 miRNAWalker2_validate -0.114609565008073 7.36690639861184e-05 NA NA NA hsa-let-7b-3p PRKAA2 -1.21979213547786 5.84575581584603e-17 0.910177606708893 0.0133266185680845 mirMAP -0.385703556647416 0.00114946510675726 NA NA NA hsa-let-7b-5p PRKAA2 -0.959013717270803 5.95127281258643e-11 0.910177606708893 0.0133266185680845 miRNAWalker2_validate;MirTarget -0.399590032732691 0.000857606952583238 NA NA NA hsa-let-7c-5p PRKAA2 -1.70744661345097 2.87934212005942e-20 0.910177606708893 0.0133266185680845 MirTarget -0.323478962357034 0.000457014156060023 NA NA NA hsa-miR-125b-5p PRKAA2 -1.35767721102906 1.16564617395164e-18 0.910177606708893 0.0133266185680845 miRNATAP -0.468131740207186 2.58447444857568e-05 NA NA NA hsa-miR-126-5p PRKAA2 -0.428561469405594 6.6035585844222e-05 0.910177606708893 0.0133266185680845 mirMAP -0.353829124273961 0.0349255565875956 NA NA NA hsa-miR-130a-3p PRKAA2 -1.53229181736223 2.91460363624872e-19 0.910177606708893 0.0133266185680845 MirTarget -0.261650172386151 0.00937218581418371 NA NA NA hsa-miR-130b-3p PRKAA2 0.687190305027546 0.000109068658562255 0.910177606708893 0.0133266185680845 MirTarget -0.39214943725483 8.93727722972995e-05 NA NA NA hsa-miR-139-5p PRKAA2 -2.11299531796557 8.16407076415038e-28 0.910177606708893 0.0133266185680845 mirMAP -0.243840459298225 0.00500077362975578 NA NA NA hsa-miR-144-3p PRKAA2 -2.97536914478815 6.00546047309683e-28 0.910177606708893 0.0133266185680845 mirMAP -0.251212728741441 4.29127796324217e-05 NA NA NA hsa-miR-16-2-3p PRKAA2 -0.0336420826463706 0.805158952566973 0.910177606708893 0.0133266185680845 mirMAP -0.457570769127741 0.000536483503983079 NA NA NA hsa-miR-195-3p PRKAA2 -1.09375690196245 4.70092324819807e-09 0.910177606708893 0.0133266185680845 mirMAP -0.528536254111941 2.17986726272341e-08 NA NA NA hsa-miR-203a-3p PRKAA2 -1.34362479226226 8.69374456831293e-05 0.910177606708893 0.0133266185680845 MirTarget -0.179382015471783 0.000540688920660811 NA NA NA hsa-miR-217 PRKAA2 1.05797297540381 0.0401026692682422 0.910177606708893 0.0133266185680845 mirMAP -0.174781811555677 3.64856315207684e-07 NA NA NA hsa-miR-22-5p PRKAA2 -0.630365901263172 3.32415348030414e-05 0.910177606708893 0.0133266185680845 mirMAP -0.407034919675641 0.000519823954254811 NA NA NA hsa-miR-26a-5p PRKAA2 -0.963792031426845 1.83360999387345e-22 0.910177606708893 0.0133266185680845 mirMAP -0.782511241662933 5.79168652076068e-06 NA NA NA hsa-miR-30e-3p PRKAA2 -1.20845647373031 3.10263633528203e-25 0.910177606708893 0.0133266185680845 MirTarget -0.527801395071765 0.000287963362506242 NA NA NA hsa-miR-30e-5p PRKAA2 -0.627815042856657 3.02205690184908e-10 0.910177606708893 0.0133266185680845 MirTarget -0.438345582649116 0.0139749918956882 NA NA NA hsa-miR-576-5p PRKAA2 -0.377452008285847 0.00470735657343984 0.910177606708893 0.0133266185680845 mirMAP -0.339109435921254 0.0119064555477781 NA NA NA hsa-miR-628-3p PRKAA2 -0.958478775877672 6.18965095549213e-08 0.910177606708893 0.0133266185680845 mirMAP -0.30159363325766 0.00298084973196401 NA NA NA hsa-let-7c-5p PRRX1 -1.70744661345097 2.87934212005942e-20 2.13747637731194 2.98162416691034e-16 MirTarget -0.352682612593982 1.66283334492681e-07 NA NA NA hsa-let-7c-5p PTGES2 -1.70744661345097 2.87934212005942e-20 0.505915263560095 4.3460926132534e-06 miRNAWalker2_validate -0.150018737330616 5.00669169745312e-08 NA NA NA hsa-let-7c-5p PTK2 -1.70744661345097 2.87934212005942e-20 0.592116034898139 1.42360483588582e-09 miRNAWalker2_validate -0.111526582483996 6.85487252665759e-06 NA NA NA hsa-let-7c-5p RAB11FIP4 -1.70744661345097 2.87934212005942e-20 1.54437373311846 7.02562100479325e-17 MirTarget -0.366743712732836 4.57221998622098e-15 NA NA NA hsa-let-7c-5p RAB34 -1.70744661345097 2.87934212005942e-20 0.412870987704762 0.126202873299987 miRNAWalker2_validate -0.284015184457008 2.48793947860605e-05 NA NA NA hsa-miR-101-3p RAC1 -1.48176407980989 3.98950707385704e-31 0.216579201672401 0.00293326905874306 miRNAWalker2_validate;MirTarget -0.160619583159355 2.13421294167009e-10 25202416;24649082;25057058 In previous studies the role of miRNA-101 miR-101 in tumors has been identified as a tumor suppressor and until now the role of miR-101 and Rac1 in thyroid cancer has remained undefined; Rac1 was demonstrated to be negatively regulated by miR-101 at the post-transcriptional level via a specific target site within the 3' untranslated region by dual-luciferase reporter assay; The expression of Rac1 was also observed to inversely correlate with miR-101 expression in PTC tissues; knockdown of Rac1 by shRNA inhibited thyroid cancer cell migration and invasion resembling that of miR-101 overexpression; Thus these findings suggested that miR-101 acts as a novel suppressor by targeting the Rac1 gene and inhibiting thyroid cancer cell migration and invasion;miR 101 inhibits cell proliferation by targeting Rac1 in papillary thyroid carcinoma; In the present study we investigated the role of microRNA-101 miR-101 in PTC via targeting of Ras-related C3 botulinum toxin substrate 1 Rac1; Moreover algorithm-based and experimental strategies verified Rac1 as a direct target of miR-101 in the K1 cell line; Taken together these findings suggest that miR-101 inhibited PTC growth via the downregulation of Rac1 expression providing a better understanding of miRNA-modulated signaling networks for future cancer therapeutics;Mir-101 inhibitors significantly increased the luciferase activities of RAC1 3'UTR; Overexpression of mir-101 increased the expression of RAC1 while inhibition of mir-101 suppressed RAC1 expression; mir-101 can suppress RAC1 gene expression by targeting the specific sequence of RAC1 3'UTR cell migration;; thyroid cancer;thyroid cancer;colorectal cancer hsa-let-7c-5p RAD18 -1.70744661345097 2.87934212005942e-20 0.734804507433037 1.25694117049507e-15 MirTarget -0.162229147179546 3.03633151346655e-12 NA NA NA hsa-let-7c-5p RAPGEFL1 -1.70744661345097 2.87934212005942e-20 0.512757940233236 0.00610377319567469 miRNAWalker2_validate -0.104672283482989 0.0263816556863234 NA NA NA hsa-let-7c-5p RFWD3 -1.70744661345097 2.87934212005942e-20 0.435632342748586 1.3132101658858e-06 miRNAWalker2_validate -0.125524002210606 2.35908018598628e-08 NA NA NA hsa-let-7c-5p RFX5 -1.70744661345097 2.87934212005942e-20 1.21360829628678 2.49921334600813e-28 MirTarget -0.142572635491316 1.08560294572442e-06 NA NA NA hsa-let-7c-5p RPL18A -1.70744661345097 2.87934212005942e-20 0.302238061682566 0.0189119255010824 miRNAWalker2_validate -0.183702992224943 7.94319049679231e-09 NA NA NA hsa-let-7c-5p RPS13 -1.70744661345097 2.87934212005942e-20 0.0402954151984805 0.688921058276665 miRNAWalker2_validate -0.10218446432348 4.42586947280731e-05 NA NA NA hsa-let-7c-5p RPS24 -1.70744661345097 2.87934212005942e-20 0.267883090577552 0.0468033270606586 miRNAWalker2_validate -0.196549606512263 3.44029551262791e-09 NA NA NA hsa-let-7c-5p SEMA3F -1.70744661345097 2.87934212005942e-20 1.45777080905473 1.56816209923569e-37 MirTarget -0.234818872817101 1.05143991596871e-14 NA NA NA hsa-let-7c-5p SEMA4F -1.70744661345097 2.87934212005942e-20 1.01208582172754 6.47089148904579e-05 MirTarget -0.273087481441457 1.81190606874631e-05 NA NA NA hsa-let-7c-5p SF3B4 -1.70744661345097 2.87934212005942e-20 1.02312871885638 7.99127216761014e-26 miRNAWalker2_validate -0.218936273994718 1.52946844995903e-18 NA NA NA hsa-miR-21-5p SKP2 1.51084295924322 1.54551622173259e-34 0.422595289761893 0.0200334942687184 miRNAWalker2_validate;MirTarget -0.199555879642397 0.00262016397392478 NA NA NA hsa-miR-30b-5p SKP2 -0.54056186708617 2.44688760798341e-05 0.422595289761893 0.0200334942687184 MirTarget;miRNATAP -0.240712598784266 0.000463630582388284 NA NA NA hsa-let-7c-5p SLC10A3 -1.70744661345097 2.87934212005942e-20 0.351752502448654 0.00188986179930041 miRNAWalker2_validate -0.182712057163013 5.67345250226885e-11 NA NA NA hsa-let-7c-5p SLC17A9 -1.70744661345097 2.87934212005942e-20 0.51327413401667 0.00962042525885391 MirTarget -0.198870581493571 6.13429852972486e-05 NA NA NA hsa-let-7c-5p SMARCC1 -1.70744661345097 2.87934212005942e-20 0.453331771984192 2.34444535272705e-08 miRNAWalker2_validate -0.12781175289705 2.68001045795896e-10 NA NA NA hsa-let-7c-5p SMARCD1 -1.70744661345097 2.87934212005942e-20 0.643238619401545 1.43047276243426e-17 miRNAWalker2_validate -0.177640467487771 1.94594245173065e-21 NA NA NA hsa-let-7c-5p SMCR8 -1.70744661345097 2.87934212005942e-20 0.453242799658724 3.50739679214307e-06 MirTarget -0.122565100231006 5.4902514084137e-07 NA NA NA hsa-let-7c-5p SOX13 -1.70744661345097 2.87934212005942e-20 0.713864896374115 5.5028190432502e-13 MirTarget -0.124273877815759 8.64473078600962e-07 NA NA NA hsa-miR-30b-3p STK4 -0.439724365151373 0.000947180503583586 -0.0242791347989213 0.739245017925932 MirTarget -0.106247080459235 5.60224295282278e-05 NA NA NA hsa-miR-30d-3p STK4 -0.120562286038759 0.329549534782125 -0.0242791347989213 0.739245017925932 mirMAP -0.132656583256455 3.19899840746635e-06 NA NA NA hsa-let-7c-5p STX3 -1.70744661345097 2.87934212005942e-20 0.268625915502391 0.0620467313021486 MirTarget -0.200597820665899 1.7582165585329e-08 NA NA NA hsa-let-7c-5p SUB1 -1.70744661345097 2.87934212005942e-20 0.583706814960803 1.03979976716946e-11 MirTarget -0.151812387295251 1.54400818436745e-12 NA NA NA hsa-let-7c-5p TAZ -1.70744661345097 2.87934212005942e-20 0.956747824088997 5.51728917847337e-22 miRNAWalker2_validate -0.160843910434223 3.98057075434146e-10 NA NA NA hsa-let-7c-5p TBC1D13 -1.70744661345097 2.87934212005942e-20 0.861209565504011 9.70398365961959e-16 MirTarget -0.174153765242454 1.81958533488793e-10 NA NA NA hsa-let-7c-5p TBKBP1 -1.70744661345097 2.87934212005942e-20 0.916427652689533 7.35042591752853e-10 MirTarget -0.255902300442293 6.22257358099485e-12 NA NA NA hsa-let-7c-5p TMEM165 -1.70744661345097 2.87934212005942e-20 0.581530725593331 1.55109884568793e-08 miRNAWalker2_validate -0.144842845795178 2.038268418118e-08 NA NA NA hsa-let-7c-5p TMEM184B -1.70744661345097 2.87934212005942e-20 0.889593464258157 1.1912658512836e-19 miRNAWalker2_validate -0.170532146688534 1.19223629021959e-11 NA NA NA hsa-let-7c-5p TRIM67 -1.70744661345097 2.87934212005942e-20 0.526474972444801 0.0261906603203476 MirTarget -0.221979298256235 0.000181660256380273 NA NA NA hsa-let-7c-5p TRIM71 -1.70744661345097 2.87934212005942e-20 1.88705329759216 3.31797883877253e-06 miRNAWalker2_validate;MirTarget -0.78785120052045 2.91205218598371e-15 NA NA NA hsa-let-7c-5p TTLL4 -1.70744661345097 2.87934212005942e-20 1.09772685973996 1.47068858470308e-10 MirTarget -0.450426278450796 7.57793283588566e-28 NA NA NA hsa-let-7c-5p UBA52 -1.70744661345097 2.87934212005942e-20 0.28393248928586 0.0110134022626622 miRNAWalker2_validate -0.106594975606236 0.000134675405654401 NA NA NA hsa-let-7c-5p ZC3H3 -1.70744661345097 2.87934212005942e-20 1.0612730707833 1.57569638197004e-20 MirTarget -0.199043730435108 1.27659419619969e-11 NA NA NA hsa-let-7c-5p ZNF512B -1.70744661345097 2.87934212005942e-20 0.949756749303405 1.79541489585724e-18 MirTarget -0.178134616117144 1.43198078159576e-10 NA NA NA hsa-let-7c-5p ZNF526 -1.70744661345097 2.87934212005942e-20 0.694364272257119 1.11242011006087e-21 miRNAWalker2_validate -0.147571959257241 1.3126555892882e-15 NA NA NA hsa-let-7c-5p ZNF581 -1.70744661345097 2.87934212005942e-20 1.08114010713937 1.93294426178797e-17 miRNAWalker2_validate -0.315580993313553 1.10992003321011e-23 NA NA NA hsa-let-7c-5p ZNF710 -1.70744661345097 2.87934212005942e-20 0.313248196006383 0.103373907581206 MirTarget -0.120535446215635 0.0125911174137927 NA NA NA