miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-106b-5p AKT3 2.80565545918114 1.14547999022566e-09 -3.32677676487603 1.45486698220293e-05 miRNATAP -0.411504731855899 9.49650030459631e-06 NA NA NA hsa-miR-142-3p AKT3 4.35304505457969 3.10014573651358e-10 -3.32677676487603 1.45486698220293e-05 miRanda -0.161022651130634 0.00933730307368185 NA NA NA hsa-miR-15a-5p AKT3 2.0535411006904 1.91108976398046e-06 -3.32677676487603 1.45486698220293e-05 miRNAWalker2_validate;miRTarBase;miRNATAP -0.374578960806042 0.000213935533400346 NA NA NA hsa-miR-15b-5p AKT3 3.32329949959268 8.40210501034588e-13 -3.32677676487603 1.45486698220293e-05 miRNATAP -0.254367737995205 0.00570754876367863 NA NA NA hsa-miR-16-5p AKT3 2.93575808220754 2.15436817162977e-10 -3.32677676487603 1.45486698220293e-05 miRNAWalker2_validate;miRTarBase;miRNATAP -0.309870666150618 0.000864570425925272 NA NA NA hsa-miR-29b-3p AKT3 0.666547117072858 0.234055379278093 -3.32677676487603 1.45486698220293e-05 miRNATAP -0.283935483475042 0.000311340903637634 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-3065-5p AKT3 2.14185373842821 0.0609400502269891 -3.32677676487603 1.45486698220293e-05 mirMAP -0.221762461081726 2.87831776854007e-06 NA NA NA hsa-miR-362-3p AKT3 0.679952485897744 0.226148468488576 -3.32677676487603 1.45486698220293e-05 miRanda -0.254988730314174 0.00123561088951897 NA NA NA hsa-miR-501-3p AKT3 1.72239979688923 0.0075900263732748 -3.32677676487603 1.45486698220293e-05 miRNATAP -0.18288683695833 0.00732967244086728 NA NA NA hsa-miR-93-5p AKT3 2.65964181833033 2.58315947526774e-08 -3.32677676487603 1.45486698220293e-05 miRNATAP -0.334744595445174 0.000214241376596223 NA NA NA hsa-miR-342-3p BCL2L1 1.31107714473009 0.0207211910724662 0.387849298249143 0.372559860651897 PITA;miRanda;miRNATAP -0.126863966321354 0.00344426702929298 NA NA NA hsa-let-7d-5p CBL 0.831142050231414 0.0126955498524287 -0.223305458230699 0.601450588204973 MirTarget -0.208607906519753 0.00470347214668052 NA NA NA hsa-miR-141-5p CBL 7.13744624551943 4.06877058732583e-26 -0.223305458230699 0.601450588204973 mirMAP -0.115794675041389 0.000398232989098249 NA NA NA hsa-miR-200c-3p CBL 6.47012025883743 2.64500707716408e-26 -0.223305458230699 0.601450588204973 MirTarget;mirMAP -0.102551823392254 0.00480588017413537 NA NA NA hsa-miR-29c-3p CBL -0.414153610337085 0.529344128062017 -0.223305458230699 0.601450588204973 mirMAP -0.123123251630821 0.000781404701279862 NA NA NA hsa-miR-30e-3p CBL -0.0362193022195196 0.932577027239525 -0.223305458230699 0.601450588204973 MirTarget -0.215252513739518 0.00015188621093179 NA NA NA hsa-miR-374a-3p CBL 0.465360399099794 0.305267458251279 -0.223305458230699 0.601450588204973 mirMAP -0.177025689484604 0.000955723283769467 NA NA NA hsa-miR-3913-5p CBL 0.145645056779437 0.734844256690741 -0.223305458230699 0.601450588204973 MirTarget;miRNATAP -0.171486582252182 0.00253430943334435 NA NA NA hsa-miR-222-5p CBLB 2.52056758362407 0.00142010793166944 -0.0617875082634471 0.893286906253173 MirTarget -0.103158310321117 0.00159333580839698 NA NA NA hsa-let-7a-5p CCND1 0.148081801547773 0.645305441523746 0.153161422157864 0.87752763573474 TargetScan;miRNATAP -0.543758028087025 0.00245174452713361 NA NA NA hsa-miR-106a-5p CCND1 3.98693608217557 9.37722470816656e-07 0.153161422157864 0.87752763573474 MirTarget;miRNATAP -0.430943892321887 6.82894757639655e-11 NA NA NA hsa-miR-15a-5p CCND1 2.0535411006904 1.91108976398046e-06 0.153161422157864 0.87752763573474 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.345671894500985 0.00776019225008181 22922827 CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR sarcoma hsa-miR-15b-5p CCND1 3.32329949959268 8.40210501034588e-13 0.153161422157864 0.87752763573474 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.423468924188888 0.000292921876666624 NA NA NA hsa-miR-20b-5p CCND1 4.5662923200279 4.75238200639144e-05 0.153161422157864 0.87752763573474 MirTarget;miRNATAP -0.306916825629866 1.73283870424345e-10 NA NA NA hsa-miR-34a-5p CCND1 0.830377770217786 0.0477544831885907 0.153161422157864 0.87752763573474 miRNAWalker2_validate;miRTarBase;miRNATAP -0.423813778518534 0.00174350326234822 25792709;21399894 This inhibition of proliferation was associated with a decrease in cyclin D1 levels orchestrated principally by HNF-4α a target of miR-34a considered to act as a tumour suppressor in the liver;Quantitative PCR and western analysis confirmed decreased expression of two genes BCL-2 and CCND1 in docetaxel-resistant cells which are both targeted by miR-34a ; liver cancer;breast cancer hsa-miR-497-5p CCND1 -1.44150596209372 0.0225146607606395 0.153161422157864 0.87752763573474 MirTarget;miRNATAP -0.249933846887954 0.00498383887238102 21350001 Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer breast cancer hsa-miR-106a-5p CCND2 3.98693608217557 9.37722470816656e-07 -2.81051675901102 0.00139983736368543 miRNATAP -0.444958981451041 2.08537025757115e-14 NA NA NA hsa-miR-106b-5p CCND2 2.80565545918114 1.14547999022566e-09 -2.81051675901102 0.00139983736368543 miRNAWalker2_validate;miRTarBase;miRNATAP -0.309595760343179 0.00374413339981401 NA NA NA hsa-miR-10a-3p CCND2 0.970411431936568 0.31667483998251 -2.81051675901102 0.00139983736368543 mirMAP -0.203238239783698 0.000109626077062705 NA NA NA hsa-miR-130b-5p CCND2 3.74118449312296 2.92266550966038e-10 -2.81051675901102 0.00139983736368543 mirMAP -0.460499923117218 1.14695292180331e-08 NA NA NA hsa-miR-141-3p CCND2 7.30474126597325 1.45115996357606e-24 -2.81051675901102 0.00139983736368543 MirTarget;TargetScan -0.239696704303332 0.000205435786708848 NA NA NA hsa-miR-15b-5p CCND2 3.32329949959268 8.40210501034588e-13 -2.81051675901102 0.00139983736368543 miRNATAP -0.527059068245043 3.31921597840683e-07 NA NA NA hsa-miR-16-2-3p CCND2 3.79845098071094 1.49120139344659e-13 -2.81051675901102 0.00139983736368543 mirMAP -0.289719520581 0.00206680066165107 NA NA NA hsa-miR-182-5p CCND2 5.86988712704738 1.22411588571584e-15 -2.81051675901102 0.00139983736368543 miRNAWalker2_validate;miRTarBase;miRNATAP -0.278474368736704 1.61949004264047e-05 NA NA NA hsa-miR-183-5p CCND2 6.61903249270777 1.00958881445636e-16 -2.81051675901102 0.00139983736368543 miRNATAP -0.288028240113034 1.0097840608077e-06 NA NA NA hsa-miR-191-5p CCND2 1.58824208483839 0.000738859004053681 -2.81051675901102 0.00139983736368543 MirTarget -0.315151097931825 0.00313941450228982 NA NA NA hsa-miR-200a-3p CCND2 6.336081120041 4.024313571871e-16 -2.81051675901102 0.00139983736368543 MirTarget -0.414829241668513 2.52639559759353e-12 NA NA NA hsa-miR-20b-5p CCND2 4.5662923200279 4.75238200639144e-05 -2.81051675901102 0.00139983736368543 miRNATAP -0.295383995634395 4.37719472717441e-12 NA NA NA hsa-miR-224-3p CCND2 2.84876340814503 0.000179138399939161 -2.81051675901102 0.00139983736368543 mirMAP -0.216162489376406 0.00100829595274067 NA NA NA hsa-miR-28-5p CCND2 -0.815636722979196 0.0221199948901761 -2.81051675901102 0.00139983736368543 miRanda -0.428938814049462 0.00272604774130058 NA NA NA hsa-miR-3065-3p CCND2 1.89496019576082 0.0308154823923145 -2.81051675901102 0.00139983736368543 MirTarget;miRNATAP -0.206941274598462 0.000265009133802388 NA NA NA hsa-miR-3065-5p CCND2 2.14185373842821 0.0609400502269891 -2.81051675901102 0.00139983736368543 mirMAP -0.198616424838265 0.000257635954140166 NA NA NA hsa-miR-30d-3p CCND2 -0.0740421896025512 0.857423650167556 -2.81051675901102 0.00139983736368543 mirMAP -0.548341190913964 7.47249707616609e-06 NA NA NA hsa-miR-324-3p CCND2 1.51345381556672 0.0038447546677657 -2.81051675901102 0.00139983736368543 miRNAWalker2_validate -0.43719832262749 4.09891269304966e-06 NA NA NA hsa-miR-33a-3p CCND2 2.06269680799532 0.00156436055383943 -2.81051675901102 0.00139983736368543 MirTarget -0.270924955791957 0.000410846654094401 NA NA NA hsa-miR-378a-3p CCND2 1.46612141870273 0.0466660641196872 -2.81051675901102 0.00139983736368543 miRNAWalker2_validate -0.186901666998984 0.00600686499792038 NA NA NA hsa-miR-429 CCND2 6.39965293994036 1.96920201593608e-18 -2.81051675901102 0.00139983736368543 miRNATAP -0.457780562605429 2.24817157133262e-13 NA NA NA hsa-miR-497-5p CCND2 -1.44150596209372 0.0225146607606395 -2.81051675901102 0.00139983736368543 MirTarget;miRNATAP -0.272420525595686 0.000579324260115001 NA NA NA hsa-miR-550a-5p CCND2 1.21781238856895 0.0613791144699551 -2.81051675901102 0.00139983736368543 MirTarget -0.224646283844048 0.00363403467531415 NA NA NA hsa-miR-660-5p CCND2 -0.0668683798854808 0.885250178390404 -2.81051675901102 0.00139983736368543 mirMAP -0.290960137515711 0.00793054638018279 NA NA NA hsa-miR-9-3p CCND2 1.69328215716742 0.125170982657059 -2.81051675901102 0.00139983736368543 MirTarget;mirMAP;miRNATAP -0.143162485603445 0.00185116011719342 NA NA NA hsa-miR-93-5p CCND2 2.65964181833033 2.58315947526774e-08 -2.81051675901102 0.00139983736368543 miRNATAP -0.48060449639845 2.62594110203289e-06 NA NA NA hsa-miR-96-5p CCND2 5.62521466029286 1.54938806718028e-10 -2.81051675901102 0.00139983736368543 TargetScan;miRNATAP -0.24395409924335 0.000303822796805944 NA NA NA hsa-miR-27b-3p CCND3 -0.0929089601968123 0.85847352206581 -0.53759657598867 0.124370433214632 miRNAWalker2_validate -0.141758210053908 0.000190546260809965 NA NA NA hsa-miR-429 CCND3 6.39965293994036 1.96920201593608e-18 -0.53759657598867 0.124370433214632 miRNATAP -0.112877673525875 7.62633278325715e-06 NA NA NA hsa-miR-96-5p CCND3 5.62521466029286 1.54938806718028e-10 -0.53759657598867 0.124370433214632 TargetScan -0.116905111437921 9.66017245986979e-06 NA NA NA hsa-miR-24-3p CISH 1.55853749533999 0.000524726461381821 -0.894106913043657 0.107331174614428 MirTarget -0.246715398384493 0.000411223469354059 NA NA NA hsa-miR-324-5p CISH 1.31253452379847 0.0116806680545163 -0.894106913043657 0.107331174614428 miRanda -0.195798047895951 0.00119565730507177 NA NA NA hsa-miR-200b-3p CNTFR 5.56167217794639 6.43540045061709e-16 -4.16050425920299 0.0242985747340731 TargetScan -0.444568741426208 0.00218000027745392 NA NA NA hsa-miR-200c-3p CNTFR 6.47012025883743 2.64500707716408e-26 -4.16050425920299 0.0242985747340731 miRNATAP -0.615684884366288 9.14142247953298e-05 NA NA NA hsa-miR-21-5p CNTFR 2.65163477806992 6.72089787690756e-16 -4.16050425920299 0.0242985747340731 miRNATAP -0.947196646804256 0.00229340920061741 NA NA NA hsa-miR-429 CNTFR 6.39965293994036 1.96920201593608e-18 -4.16050425920299 0.0242985747340731 PITA;miRanda;miRNATAP -0.370645000787899 0.00625482589716182 NA NA NA hsa-miR-589-5p CNTFR 1.55790780760302 0.000326340665093671 -4.16050425920299 0.0242985747340731 miRNATAP -0.626247546903876 0.00998599789237002 NA NA NA hsa-miR-21-3p CREBBP 3.50297439576639 6.39946844099206e-10 -0.3958302023172 0.180670093990074 MirTarget -0.1378273582574 1.08112070034993e-06 NA NA NA hsa-miR-590-3p CREBBP 2.35429565068338 2.79601879608564e-06 -0.3958302023172 0.180670093990074 PITA;miRanda;mirMAP;miRNATAP -0.100352894791816 0.00219317602458258 NA NA NA hsa-miR-217 CSF2RA -0.378397407994341 0.717408682071252 1.04776346371705 0.283077659477753 miRanda -0.228150504591418 1.4962792894261e-05 NA NA NA hsa-miR-429 CSF2RA 6.39965293994036 1.96920201593608e-18 1.04776346371705 0.283077659477753 miRanda -0.222154743968322 0.00181852523263283 NA NA NA hsa-miR-15b-3p CSF2RB 3.57530146629867 5.89922785773482e-11 -0.531949678174437 0.52469724338113 mirMAP -0.243883163153962 0.00378871588753218 NA NA NA hsa-miR-19b-3p CSF2RB 1.67581705793313 0.000858910586302716 -0.531949678174437 0.52469724338113 MirTarget -0.249978645254246 0.00793124384654011 NA NA NA hsa-miR-30b-3p CSF2RB 0.169674321578618 0.766080356926625 -0.531949678174437 0.52469724338113 MirTarget -0.278521035137442 0.000870863627134223 NA NA NA hsa-miR-30b-3p CSF3R 0.169674321578618 0.766080356926625 0.315128639356519 0.723537108755114 MirTarget -0.249262137728515 0.00527678366341842 NA NA NA hsa-miR-361-5p CSF3R 0.00649167180664723 0.985202350239079 0.315128639356519 0.723537108755114 miRanda -0.605979218340613 3.40398030804743e-05 NA NA NA hsa-miR-429 CSF3R 6.39965293994036 1.96920201593608e-18 0.315128639356519 0.723537108755114 miRanda -0.202612358524427 0.00181334813811197 NA NA NA hsa-miR-185-5p CTF1 2.46768243458192 6.53179875424217e-08 -2.59684581187396 0.000528143207974454 MirTarget -0.407641434846748 8.68229678815413e-06 NA NA NA hsa-miR-342-3p CTF1 1.31107714473009 0.0207211910724662 -2.59684581187396 0.000528143207974454 miRanda -0.23008342560268 0.00231666891615306 NA NA NA hsa-miR-148a-3p EP300 1.1031350648218 0.052038169812979 0.224331914964019 0.578934208058052 miRNATAP -0.104185690998739 0.00975228544208279 NA NA NA hsa-miR-30c-5p EP300 0.38723991118075 0.348605235643473 0.224331914964019 0.578934208058052 miRNAWalker2_validate -0.18542784496307 0.000897194160521004 NA NA NA hsa-miR-339-5p EP300 1.23326828594484 0.0307501214818698 0.224331914964019 0.578934208058052 miRanda -0.199156483102611 4.47682764951844e-07 NA NA NA hsa-miR-342-3p EP300 1.31107714473009 0.0207211910724662 0.224331914964019 0.578934208058052 MirTarget;PITA;miRanda;miRNATAP -0.115722711407846 0.00406603413994019 NA NA NA hsa-miR-374b-5p EP300 -0.114749866169918 0.764888930049438 0.224331914964019 0.578934208058052 mirMAP;miRNATAP -0.159199926258203 0.00855691297646884 NA NA NA hsa-miR-590-3p EP300 2.35429565068338 2.79601879608564e-06 0.224331914964019 0.578934208058052 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.136964991854083 0.00229030845745203 NA NA NA hsa-miR-15a-5p GHR 2.0535411006904 1.91108976398046e-06 -3.30441572530682 0.0133498021134927 MirTarget;miRNATAP -0.681154907599641 9.24104831714877e-05 NA NA NA hsa-miR-15b-5p GHR 3.32329949959268 8.40210501034588e-13 -3.30441572530682 0.0133498021134927 MirTarget;miRNATAP -0.517993741994565 0.00106382975468503 NA NA NA hsa-miR-16-2-3p GHR 3.79845098071094 1.49120139344659e-13 -3.30441572530682 0.0133498021134927 mirMAP -0.501720617358561 0.000411619192161155 NA NA NA hsa-miR-16-5p GHR 2.93575808220754 2.15436817162977e-10 -3.30441572530682 0.0133498021134927 MirTarget;miRNATAP -0.561520754201017 0.000456953779533557 NA NA NA hsa-miR-3065-5p GHR 2.14185373842821 0.0609400502269891 -3.30441572530682 0.0133498021134927 MirTarget -0.382624986901816 2.82575815241532e-06 NA NA NA hsa-miR-338-5p GHR -0.108304629897487 0.894675560494607 -3.30441572530682 0.0133498021134927 PITA -0.502767794585058 4.25333085957161e-08 NA NA NA hsa-miR-7-1-3p GHR 1.43074343339835 0.00471215970502094 -3.30441572530682 0.0133498021134927 MirTarget;mirMAP -0.409557384279444 0.00647708206229191 NA NA NA hsa-miR-1271-5p IFNAR2 0.212382644103427 0.742544160267329 -0.0533929917619993 0.876582967690528 mirMAP -0.126034803018463 2.42204092211989e-05 NA NA NA hsa-miR-508-3p IFNE 0.975099105064348 0.439528954969797 4.55600906933286 0.000319440259371706 MirTarget -0.167045942410399 0.00391462008533382 NA NA NA hsa-miR-125a-5p IFNG -1.32352790615388 0.00714301627309467 3.94104665711828 0.00510150901825191 miRanda -0.637406884218199 8.76838777034272e-05 NA NA NA hsa-miR-369-3p IFNG 0.369191262196168 0.638760863212543 3.94104665711828 0.00510150901825191 PITA;miRNATAP -0.305363909941883 0.00283324153759366 NA NA NA hsa-miR-409-3p IFNG 0.293056353099264 0.67815482695354 3.94104665711828 0.00510150901825191 miRNAWalker2_validate -0.434967349237788 0.000124210543621997 NA NA NA hsa-miR-429 IFNG 6.39965293994036 1.96920201593608e-18 3.94104665711828 0.00510150901825191 miRanda -0.299498705059905 0.00377911708833624 NA NA NA hsa-miR-362-3p IFNGR1 0.679952485897744 0.226148468488576 0.1189495094481 0.788708326293671 miRanda -0.121292319755699 0.00700680197591948 NA NA NA hsa-miR-429 IFNGR1 6.39965293994036 1.96920201593608e-18 0.1189495094481 0.788708326293671 miRNATAP -0.133018058184646 3.38134640757746e-05 NA NA NA hsa-miR-375 IFNK 3.3784490463318 0.0449946294355695 1.68433049850192 0.22277695925911 miRanda -0.178806133819676 9.83005133046901e-05 NA NA NA hsa-miR-106a-5p IL10 3.98693608217557 9.37722470816656e-07 2.5497470417419 0.00204527932105029 miRNAWalker2_validate -0.173469145569538 0.00228234874850918 NA NA NA hsa-miR-361-5p IL10 0.00649167180664723 0.985202350239079 2.5497470417419 0.00204527932105029 MirTarget;PITA;miRanda;miRNATAP -0.367947589942146 0.00760047975385206 NA NA NA hsa-miR-3607-3p IL11 1.38015131722213 0.0240067155694847 2.82397235355373 0.0139109123383019 MirTarget -0.369029107787149 0.000529202367086408 NA NA NA hsa-miR-330-5p IL11RA 2.25110496739954 0.000275527655397415 -2.49238019364918 7.79494682524984e-06 miRanda -0.226009527284094 9.02094111081211e-06 NA NA NA hsa-miR-217 IL12RB1 -0.378397407994341 0.717408682071252 1.63337985023477 0.0959997723302216 miRanda -0.15148513955763 0.00464260577534847 NA NA NA hsa-miR-125a-5p IL12RB2 -1.32352790615388 0.00714301627309467 4.34518986400779 0.00343929338392892 miRanda -1.12192487335119 2.18283408867966e-11 NA NA NA hsa-miR-129-5p IL12RB2 -2.66843722411409 0.00695783358331245 4.34518986400779 0.00343929338392892 miRanda -0.323661026519258 0.000168645534686237 NA NA NA hsa-miR-28-5p IL12RB2 -0.815636722979196 0.0221199948901761 4.34518986400779 0.00343929338392892 miRanda -0.870606734850166 0.000297134938751098 NA NA NA hsa-miR-338-3p IL12RB2 0.447551118940466 0.558485097370031 4.34518986400779 0.00343929338392892 miRanda -0.605061977813636 2.66286908359056e-08 NA NA NA hsa-miR-16-2-3p IL13RA1 3.79845098071094 1.49120139344659e-13 0.0632538454392515 0.87402774613379 MirTarget -0.111177354526671 0.0084930405572384 NA NA NA hsa-miR-378a-5p IL13RA1 1.25775140086104 0.0500877723587615 0.0632538454392515 0.87402774613379 MirTarget -0.117652538637946 0.000766397556766571 NA NA NA hsa-miR-129-5p IL15 -2.66843722411409 0.00695783358331245 0.465169356458177 0.598108692321668 miRanda -0.278427011009127 2.67964756543556e-08 NA NA NA hsa-miR-130b-3p IL15 3.9204771543282 1.2714917955808e-11 0.465169356458177 0.598108692321668 MirTarget -0.474391480902627 6.90220060227263e-09 NA NA NA hsa-miR-301a-3p IL15 1.99338115332667 0.000813358604963724 0.465169356458177 0.598108692321668 MirTarget -0.258250382098669 0.00196518341564906 NA NA NA hsa-miR-324-5p IL15 1.31253452379847 0.0116806680545163 0.465169356458177 0.598108692321668 miRanda -0.326276713254996 0.000669600602729267 NA NA NA hsa-miR-421 IL15 1.97624148591545 0.000915838012451138 0.465169356458177 0.598108692321668 miRanda -0.277368606921639 0.000895477513886754 NA NA NA hsa-miR-429 IL15 6.39965293994036 1.96920201593608e-18 0.465169356458177 0.598108692321668 miRanda -0.252665934473771 7.98172749078667e-05 NA NA NA hsa-miR-493-5p IL15 0.170487141312394 0.834200945899452 0.465169356458177 0.598108692321668 MirTarget -0.20873400857523 0.000658566188988613 NA NA NA hsa-miR-125a-5p IL15RA -1.32352790615388 0.00714301627309467 -0.806516714078574 0.207197836972746 miRanda -0.201614086834458 0.00632740004356317 NA NA NA hsa-miR-199a-5p IL15RA -1.24888110793613 0.0747755616523728 -0.806516714078574 0.207197836972746 miRanda -0.206525539015103 5.66402807897169e-05 NA NA NA hsa-miR-28-5p IL15RA -0.815636722979196 0.0221199948901761 -0.806516714078574 0.207197836972746 miRanda -0.279140215280834 0.00692088637733277 NA NA NA hsa-miR-335-3p IL19 1.19503568251824 0.0938852560631551 0.993903060870162 0.529323441499014 MirTarget -0.367708931483819 0.00335654911702186 NA NA NA hsa-miR-125a-3p IL20RB -0.0748960586927341 0.920735897434087 5.70558215440896 0.00123020132697223 miRanda -0.439628606705779 0.00103998231025196 NA NA NA hsa-miR-28-5p IL20RB -0.815636722979196 0.0221199948901761 5.70558215440896 0.00123020132697223 miRanda -1.38766742470177 1.0296444262471e-06 NA NA NA hsa-miR-199a-5p IL21R -1.24888110793613 0.0747755616523728 2.85404247045817 0.0044432979679215 miRanda -0.258673395720056 0.00148068525415892 NA NA NA hsa-miR-335-5p IL21R 0.167216045757305 0.803897055331049 2.85404247045817 0.0044432979679215 miRNAWalker2_validate -0.26829553684467 0.00159164387329272 NA NA NA hsa-miR-125a-5p IL22RA1 -1.32352790615388 0.00714301627309467 3.48442338504675 7.36465484628176e-05 miRanda -0.372825070674728 0.000266782431372363 NA NA NA hsa-miR-129-5p IL22RA2 -2.66843722411409 0.00695783358331245 3.1333005414364 0.0223084856737432 miRanda -0.298251047462091 0.00016629254023286 NA NA NA hsa-miR-361-5p IL24 0.00649167180664723 0.985202350239079 2.49788460000559 0.111561132992633 miRanda -0.757044571086156 0.00361019128850431 NA NA NA hsa-miR-429 IL24 6.39965293994036 1.96920201593608e-18 2.49788460000559 0.111561132992633 miRanda -0.31197600848157 0.00665783474264685 NA NA NA hsa-miR-199a-5p IL2RA -1.24888110793613 0.0747755616523728 2.59665250906558 0.00694516409433377 miRanda -0.280001757042261 0.000319245373954421 NA NA NA hsa-miR-3065-3p IL2RA 1.89496019576082 0.0308154823923145 2.59665250906558 0.00694516409433377 MirTarget -0.211093568337215 0.000660400303399024 NA NA NA hsa-miR-375 IL2RA 3.3784490463318 0.0449946294355695 2.59665250906558 0.00694516409433377 miRanda -0.179444535009697 1.45877104995161e-08 NA NA NA hsa-miR-500a-3p IL2RA 0.515751555939967 0.335082072556095 2.59665250906558 0.00694516409433377 MirTarget -0.308693938165126 0.00270159749620831 NA NA NA hsa-miR-145-5p IL2RB -3.55505374822025 5.45525288912869e-07 1.37836826636696 0.103487872894286 mirMAP -0.22134225926689 0.000836838852824373 NA NA NA hsa-miR-299-5p IL2RB -1.25990656735684 0.103526045570924 1.37836826636696 0.103487872894286 mirMAP -0.183200680637314 0.00368295140844831 NA NA NA hsa-miR-331-3p IL4R 2.60769294751513 3.84318952029483e-07 0.367232990824394 0.543445227259428 miRNAWalker2_validate -0.17555951987969 0.00755399043568841 NA NA NA hsa-miR-429 IL4R 6.39965293994036 1.96920201593608e-18 0.367232990824394 0.543445227259428 miRNATAP -0.211673427550519 1.16441959018182e-06 NA NA NA hsa-miR-491-5p IL4R 0.569358547192776 0.313310594748302 0.367232990824394 0.543445227259428 miRanda -0.192269800927414 0.00182061138467756 NA NA NA hsa-miR-429 IL6 6.39965293994036 1.96920201593608e-18 -0.812372330269044 0.556990548550307 miRanda -0.497764450854261 5.94299314121074e-07 NA NA NA hsa-miR-130a-5p IL6R 1.58028512890005 0.024346333013728 -1.31785211161377 0.119283125010066 MirTarget;miRNATAP -0.197154960184132 0.00453478423438423 NA NA NA hsa-miR-141-3p IL6R 7.30474126597325 1.45115996357606e-24 -1.31785211161377 0.119283125010066 MirTarget -0.18243024553302 0.0032330457577678 NA NA NA hsa-miR-182-5p IL6R 5.86988712704738 1.22411588571584e-15 -1.31785211161377 0.119283125010066 mirMAP -0.181775798059133 0.00348128970964907 NA NA NA hsa-miR-200a-3p IL6R 6.336081120041 4.024313571871e-16 -1.31785211161377 0.119283125010066 MirTarget -0.189664840614486 0.00116015340974738 NA NA NA hsa-let-7a-3p IL6ST 0.82512001802525 0.0468122405194487 -0.266389395019744 0.817842594179867 mirMAP -0.522655318508249 0.00102549845703917 NA NA NA hsa-miR-1301-3p IL6ST 2.0309605405243 0.000960892301214288 -0.266389395019744 0.817842594179867 MirTarget -0.366028670877904 0.000528629727154935 NA NA NA hsa-miR-148b-5p IL6ST 2.80812018666078 3.97536665756679e-08 -0.266389395019744 0.817842594179867 mirMAP -0.399822662275585 0.00150112399743342 NA NA NA hsa-miR-182-5p IL6ST 5.86988712704738 1.22411588571584e-15 -0.266389395019744 0.817842594179867 mirMAP -0.313371751467497 0.000211287028555452 NA NA NA hsa-miR-24-1-5p IL6ST -0.638925193416348 0.236125310537158 -0.266389395019744 0.817842594179867 MirTarget -0.364910010727611 0.00278111836143377 NA NA NA hsa-miR-26b-5p IL6ST 0.314414148564179 0.461628303578321 -0.266389395019744 0.817842594179867 mirMAP -0.407160452875754 0.00881651375220223 NA NA NA hsa-miR-28-3p IL6ST -0.992446114847535 0.0188188359018203 -0.266389395019744 0.817842594179867 mirMAP -0.47896862373614 0.00217386881430802 NA NA NA hsa-miR-29b-2-5p IL6ST -0.596051745078872 0.189540844841389 -0.266389395019744 0.817842594179867 mirMAP -0.426364667554584 0.00338361421897469 NA NA NA hsa-miR-30b-5p IL6ST 0.0238659735605804 0.953223658270319 -0.266389395019744 0.817842594179867 mirMAP -0.476625120186572 0.00352380381092217 NA NA NA hsa-miR-335-5p IL6ST 0.167216045757305 0.803897055331049 -0.266389395019744 0.817842594179867 miRNAWalker2_validate -0.275358382123769 0.00474067768453453 NA NA NA hsa-miR-33a-3p IL6ST 2.06269680799532 0.00156436055383943 -0.266389395019744 0.817842594179867 mirMAP -0.261485246944929 0.00926761615513968 NA NA NA hsa-miR-33b-5p IL6ST 4.77891217497671 1.33695107675057e-08 -0.266389395019744 0.817842594179867 mirMAP -0.23626866565495 0.00191268548035721 NA NA NA hsa-miR-362-5p IL6ST -1.22309034685697 0.0452665543907975 -0.266389395019744 0.817842594179867 mirMAP -0.277097971754084 0.00989095583769076 NA NA NA hsa-miR-374a-3p IL6ST 0.465360399099794 0.305267458251279 -0.266389395019744 0.817842594179867 mirMAP -0.443230927144451 0.00233736061683871 NA NA NA hsa-miR-505-3p IL6ST 0.58881333170866 0.226937454637888 -0.266389395019744 0.817842594179867 MirTarget -0.431522752537693 0.00141612682526392 NA NA NA hsa-miR-590-3p IL6ST 2.35429565068338 2.79601879608564e-06 -0.266389395019744 0.817842594179867 miRNAWalker2_validate;miRanda;mirMAP;miRNATAP -0.40875865089807 0.00151434299506644 NA NA NA hsa-miR-592 IL6ST 2.80403350008555 0.0293520213681333 -0.266389395019744 0.817842594179867 PITA -0.186606788800028 0.00271576510136512 NA NA NA hsa-miR-7-1-3p IL6ST 1.43074343339835 0.00471215970502094 -0.266389395019744 0.817842594179867 mirMAP -0.34253944731739 0.0082504343051238 NA NA NA hsa-miR-708-3p IL6ST 0.781444321399141 0.290645825716608 -0.266389395019744 0.817842594179867 mirMAP -0.245752735260215 0.00555573829642121 NA NA NA hsa-miR-129-5p IL7 -2.66843722411409 0.00695783358331245 1.2709847744185 0.101426762909784 miRanda -0.210681735704013 2.08028542064594e-06 NA NA NA hsa-miR-335-3p IL7 1.19503568251824 0.0938852560631551 1.2709847744185 0.101426762909784 mirMAP -0.203178540524723 0.000956503373722724 NA NA NA hsa-miR-335-3p IL7R 1.19503568251824 0.0938852560631551 1.30570894046381 0.274343453036421 mirMAP -0.360345945479883 0.000134066551236259 NA NA NA hsa-miR-508-3p IL7R 0.975099105064348 0.439528954969797 1.30570894046381 0.274343453036421 mirMAP -0.213207042989268 7.38673595729549e-05 NA NA NA hsa-miR-17-5p IRF9 2.3269271449522 2.13987445663942e-05 0.80913160702855 0.0753057419076235 TargetScan -0.140778248510925 0.00251626593282966 NA NA NA hsa-miR-106b-5p JAK1 2.80565545918114 1.14547999022566e-09 -0.607027067000509 0.0409054602478455 miRNAWalker2_validate;MirTarget -0.175735146885168 5.72236425533004e-07 NA NA NA hsa-miR-15b-5p JAK1 3.32329949959268 8.40210501034588e-13 -0.607027067000509 0.0409054602478455 miRNAWalker2_validate -0.128316156661929 0.000225441178274573 NA NA NA hsa-miR-17-5p JAK1 2.3269271449522 2.13987445663942e-05 -0.607027067000509 0.0409054602478455 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.143204878903465 1.7592776639734e-06 NA NA NA hsa-miR-20a-5p JAK1 2.13553469875764 0.000181201072324354 -0.607027067000509 0.0409054602478455 MirTarget -0.107022282760873 0.0002295140502555 NA NA NA hsa-miR-30b-5p JAK1 0.0238659735605804 0.953223658270319 -0.607027067000509 0.0409054602478455 MirTarget -0.158824662202472 0.000132583501944976 NA NA NA hsa-miR-93-5p JAK1 2.65964181833033 2.58315947526774e-08 -0.607027067000509 0.0409054602478455 MirTarget;miRNATAP -0.178160799629543 1.56601979979517e-07 NA NA NA hsa-miR-181b-5p JAK2 1.11397227523501 0.0273417050354018 -0.336326790557259 0.592787818955037 mirMAP -0.192618204419721 0.00651043610634605 NA NA NA hsa-miR-335-5p JAK2 0.167216045757305 0.803897055331049 -0.336326790557259 0.592787818955037 miRNAWalker2_validate -0.209615118003146 6.79293979136461e-05 NA NA NA hsa-miR-375 LEP 3.3784490463318 0.0449946294355695 -0.0328371601993025 0.984614756452827 mirMAP -0.176812864945117 0.00184469002513877 NA NA NA hsa-miR-130b-5p LEPR 3.74118449312296 2.92266550966038e-10 -3.7227705260299 1.38515788239369e-08 mirMAP -0.217771694909696 0.000463371331673092 NA NA NA hsa-miR-150-5p LEPR 1.76769157530064 0.0593795975117846 -3.7227705260299 1.38515788239369e-08 mirMAP -0.10848354373217 0.00737810754600121 NA NA NA hsa-miR-16-1-3p LEPR 2.83281226969693 7.54359864580834e-09 -3.7227705260299 1.38515788239369e-08 mirMAP -0.342036158364644 5.88094877501124e-06 NA NA NA hsa-miR-16-2-3p LEPR 3.79845098071094 1.49120139344659e-13 -3.7227705260299 1.38515788239369e-08 mirMAP -0.328921436810999 3.20663997724762e-06 NA NA NA hsa-miR-33a-3p LEPR 2.06269680799532 0.00156436055383943 -3.7227705260299 1.38515788239369e-08 mirMAP -0.230626237409561 7.00017978880407e-05 NA NA NA hsa-miR-362-3p LEPR 0.679952485897744 0.226148468488576 -3.7227705260299 1.38515788239369e-08 miRanda -0.253794836822165 0.000189005423748519 NA NA NA hsa-miR-429 LEPR 6.39965293994036 1.96920201593608e-18 -3.7227705260299 1.38515788239369e-08 miRanda;miRNATAP -0.223725354487535 4.14323403460405e-06 NA NA NA hsa-miR-590-3p LEPR 2.35429565068338 2.79601879608564e-06 -3.7227705260299 1.38515788239369e-08 miRanda;mirMAP -0.27979962370159 0.000179337432495116 NA NA NA hsa-miR-660-5p LEPR -0.0668683798854808 0.885250178390404 -3.7227705260299 1.38515788239369e-08 MirTarget -0.215058963966481 0.00968671425869594 NA NA NA hsa-miR-150-5p LIF 1.76769157530064 0.0593795975117846 -0.927643742565293 0.37762051461438 mirMAP -0.289965583775815 3.63400485694634e-06 NA NA NA hsa-miR-224-5p LIF 4.2725754042941 6.99983365278436e-06 -0.927643742565293 0.37762051461438 mirMAP -0.225854856317066 0.00022954389553473 NA NA NA hsa-miR-708-5p LIF 1.70409736218557 0.0319538709865338 -0.927643742565293 0.37762051461438 miRNATAP -0.195664089532253 0.00891191566130374 NA NA NA hsa-miR-19a-3p LIFR 2.17020503944519 0.00122084653711062 -4.50998571221338 7.2608759563341e-06 mirMAP -0.238595234196792 0.0053792233387816 NA NA NA hsa-miR-19b-3p LIFR 1.67581705793313 0.000858910586302716 -4.50998571221338 7.2608759563341e-06 mirMAP -0.339012059220173 0.00317083543404106 NA NA NA hsa-miR-203a-3p LIFR 6.35084246337388 7.89944323347948e-08 -4.50998571221338 7.2608759563341e-06 MirTarget -0.372195970739881 2.83238982381718e-16 NA NA NA hsa-miR-205-5p LIFR 8.08298115900323 3.83045179398654e-07 -4.50998571221338 7.2608759563341e-06 mirMAP -0.135983552263616 0.000116421430561979 NA NA NA hsa-miR-221-3p LIFR 0.94082283577318 0.174749164179978 -4.50998571221338 7.2608759563341e-06 miRNATAP -0.314994295195921 0.000149539694761308 NA NA NA hsa-miR-222-3p LIFR 1.54730827524553 0.0223014220569407 -4.50998571221338 7.2608759563341e-06 miRNATAP -0.316845764382095 0.000189290871083715 NA NA NA hsa-miR-27a-3p LIFR 1.76094007417453 0.000216137556256765 -4.50998571221338 7.2608759563341e-06 miRNAWalker2_validate;MirTarget;miRNATAP -0.387847720378661 0.00136453632535486 NA NA NA hsa-miR-27b-3p LIFR -0.0929089601968123 0.85847352206581 -4.50998571221338 7.2608759563341e-06 MirTarget;miRNATAP -0.346257406897296 0.00193565761262628 NA NA NA hsa-miR-429 LIFR 6.39965293994036 1.96920201593608e-18 -4.50998571221338 7.2608759563341e-06 miRanda -0.244766167334856 0.00100976168817206 NA NA NA hsa-miR-590-3p LIFR 2.35429565068338 2.79601879608564e-06 -4.50998571221338 7.2608759563341e-06 miRanda;mirMAP -0.303675713348195 0.00778143014108849 NA NA NA hsa-miR-590-5p LIFR 1.51400888103768 0.0023888567923017 -4.50998571221338 7.2608759563341e-06 PITA;miRNATAP -0.325768595050952 0.0050403484092676 NA NA NA hsa-miR-629-3p LIFR 3.48282157979573 4.9176538695908e-08 -4.50998571221338 7.2608759563341e-06 miRNATAP -0.317469636537412 0.000328762757247655 NA NA NA hsa-miR-9-5p LIFR 1.79620806707734 0.14526963042518 -4.50998571221338 7.2608759563341e-06 miRNATAP -0.143311928456461 0.00213136296058612 NA NA NA hsa-miR-944 LIFR 7.20925181386398 0.000823207457340648 -4.50998571221338 7.2608759563341e-06 mirMAP -0.122980156294579 0.000184664690914987 NA NA NA hsa-miR-34a-5p MYC 0.830377770217786 0.0477544831885907 -0.745260197790044 0.453852120838847 miRNAWalker2_validate;miRTarBase -0.427487830189717 0.00161403194033986 25572695;25686834;21460242;22159222;23640973;22830357;22235332 The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;miR 34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c Myc pathway;Myc mediated repression of microRNA 34a promotes high grade transformation of B cell lymphoma by dysregulation of FoxP1;MicroRNA 34a suppresses malignant transformation by targeting c Myc transcriptional complexes in human renal cell carcinoma; We investigated the functional effects of microRNA-34a miR-34a on c-Myc transcriptional complexes in renal cell carcinoma; miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region which was revealed by luciferase reporter assays; Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription indicating a novel role of miR-34a in the regulation of transcription by c-Myc;Among them miR-34a was also associated with poor prognosis in 2 independent series of leukemic and nodal MCL and in cooperation with high expression of the MYC oncogene;We report that miR-34a did not inhibit cell proliferation notwithstanding a marked down-regulation of c-MYC;MicroRNA 34a modulates c Myc transcriptional complexes to suppress malignancy in human prostate cancer cells; We studied the functional effects of miR-34a on c-Myc transcriptional complexes in PC-3 prostate cancer cells; miR-34a downregulated expression of c-Myc oncogene by targeting its 3' UTR as shown by luciferase reporter assays; This is the first report to document that miR-34a suppresses assembly and function of the c-Myc-Skp2-Miz1 complex that activates RhoA and the c-Myc-pTEFB complex that elongates transcription of various genes suggesting a novel role of miR-34a in the regulation of transcription by c-Myc complex ;;;malignant trasformation;worse prognosis;; bladder cancer;liver cancer;B cell lymphoma;kidney renal cell cancer;lymphoma;lymphoma;prostate cancer hsa-miR-429 MYC 6.39965293994036 1.96920201593608e-18 -0.745260197790044 0.453852120838847 miRNAWalker2_validate -0.351232938868747 9.84375821791447e-07 21684154;24633485 miR 429 modulates the expression of c myc in human gastric carcinoma cells; SGC-7901 gastric cancer cells were transfected with miR-429 mimics and endogenous c-myc expression was detected by western blots; We performed functional assays using the 3'UTR of the c-myc gene as a miR-429 target in a luciferase reporter assay system; miR-429 significantly downregulated endogenous c-myc expression in SGC-7901 cells; Action of miR/429 on c-myc 3'UTR was confirmed; c-myc is an important miR-429 target gene;It is known that miR-429 is down-regulated and functions as a tumor suppressor by targeting c-myc and PLGG1 in gastric and breast cancer ; gastric cancer;sarcoma hsa-miR-196b-5p OSMR -0.103579538052452 0.859017000109845 0.550487651528275 0.505425947189116 miRNATAP -0.223545467125938 0.00558557810621312 NA NA NA hsa-miR-200b-3p OSMR 5.56167217794639 6.43540045061709e-16 0.550487651528275 0.505425947189116 TargetScan -0.304673120822428 1.88108458680799e-06 NA NA NA hsa-miR-362-3p OSMR 0.679952485897744 0.226148468488576 0.550487651528275 0.505425947189116 miRanda -0.316285955291011 0.000152555758070928 NA NA NA hsa-miR-429 OSMR 6.39965293994036 1.96920201593608e-18 0.550487651528275 0.505425947189116 miRanda;miRNATAP -0.26582134520331 8.74964941476044e-06 NA NA NA hsa-miR-181b-5p PIAS2 1.11397227523501 0.0273417050354018 0.441301095379962 0.297986758918323 mirMAP -0.126562022421556 0.0079387483608847 NA NA NA hsa-miR-582-5p PIAS2 0.685177900016753 0.447761540297692 0.441301095379962 0.297986758918323 MirTarget -0.111793577278943 2.12110377277504e-05 NA NA NA hsa-miR-181b-5p PIAS3 1.11397227523501 0.0273417050354018 0.522509879608753 0.233360181630875 miRNATAP -0.136346053505465 0.00567982447543558 NA NA NA hsa-miR-3922-3p PIAS3 2.5745007343008 8.26367348669111e-05 0.522509879608753 0.233360181630875 MirTarget;miRNATAP -0.136234428625851 0.000386312248336948 NA NA NA hsa-miR-148b-3p PIK3CA 1.75622244535669 8.84414356040579e-08 0.514328426212782 0.248930105421785 miRNAWalker2_validate -0.244141801200414 0.00147579635788138 NA NA NA hsa-miR-186-5p PIK3CA 0.445443449112564 0.185447310527704 0.514328426212782 0.248930105421785 mirMAP -0.280960133798979 0.000232701716483115 NA NA NA hsa-miR-29b-1-5p PIK3CA 0.33698032160171 0.598092174563471 0.514328426212782 0.248930105421785 mirMAP -0.12089066483943 0.00233700941849917 NA NA NA hsa-miR-320b PIK3CA 0.20205459771295 0.727216419960509 0.514328426212782 0.248930105421785 miRanda -0.121444800770151 0.00550932456475504 NA NA NA hsa-miR-335-5p PIK3CA 0.167216045757305 0.803897055331049 0.514328426212782 0.248930105421785 miRNAWalker2_validate -0.124494566731403 0.000883627732385134 NA NA NA hsa-miR-338-5p PIK3CA -0.108304629897487 0.894675560494607 0.514328426212782 0.248930105421785 mirMAP -0.108048495334147 0.00046563589386498 NA NA NA hsa-miR-339-5p PIK3CA 1.23326828594484 0.0307501214818698 0.514328426212782 0.248930105421785 miRanda -0.13798173006655 0.00178425799549926 NA NA NA hsa-miR-501-5p PIK3CA 1.0411896821345 0.0777206709183552 0.514328426212782 0.248930105421785 mirMAP -0.120904681333791 0.00473986403400753 NA NA NA hsa-miR-130a-3p PIK3CB 0.176861046122832 0.7577473016872 0.897158330473952 0.0125840363244796 miRNATAP -0.116582529549782 0.00106378240800672 NA NA NA hsa-miR-19b-3p PIK3CB 1.67581705793313 0.000858910586302716 0.897158330473952 0.0125840363244796 miRNATAP -0.110401307134748 0.00639042894521705 NA NA NA hsa-miR-1468-5p PIK3CD -1.63442718498426 0.00779372976116312 0.0551399776366237 0.926564879247674 MirTarget -0.153354934509346 0.00559561965869134 NA NA NA hsa-miR-199a-5p PIK3CD -1.24888110793613 0.0747755616523728 0.0551399776366237 0.926564879247674 MirTarget;PITA;miRanda;miRNATAP -0.160352223725155 0.000860262558034989 NA NA NA hsa-miR-30d-5p PIK3CD 0.302504510257496 0.380193536606962 0.0551399776366237 0.926564879247674 MirTarget;miRNATAP -0.269704587228763 0.00722775970426478 NA NA NA hsa-miR-3913-5p PIK3CD 0.145645056779437 0.734844256690741 0.0551399776366237 0.926564879247674 mirMAP -0.258109601835399 0.00117084989668902 NA NA NA hsa-miR-335-3p PIK3CG 1.19503568251824 0.0938852560631551 -0.156343505309127 0.848670326900117 mirMAP -0.289128547018831 6.98940085423769e-06 NA NA NA hsa-miR-16-2-3p PIK3R1 3.79845098071094 1.49120139344659e-13 -1.85375256159008 0.0127438113463991 MirTarget -0.220421111740374 0.0054973163518176 NA NA NA hsa-miR-16-5p PIK3R1 2.93575808220754 2.15436817162977e-10 -1.85375256159008 0.0127438113463991 MirTarget -0.232718839097215 0.0094069232214411 NA NA NA hsa-miR-17-5p PIK3R1 2.3269271449522 2.13987445663942e-05 -1.85375256159008 0.0127438113463991 MirTarget;TargetScan;miRNATAP -0.263550021803503 0.000561403048031031 NA NA NA hsa-miR-200c-3p PIK3R1 6.47012025883743 2.64500707716408e-26 -1.85375256159008 0.0127438113463991 mirMAP -0.209884750055895 0.000971059963262446 NA NA NA hsa-miR-29b-3p PIK3R1 0.666547117072858 0.234055379278093 -1.85375256159008 0.0127438113463991 MirTarget;miRNATAP -0.229458801110313 0.00247922380727846 NA NA NA hsa-miR-3065-5p PIK3R1 2.14185373842821 0.0609400502269891 -1.85375256159008 0.0127438113463991 MirTarget;mirMAP;miRNATAP -0.136442762182432 0.00300321263691178 NA NA NA hsa-miR-320c PIK3R1 -0.10618808730545 0.854002814666472 -1.85375256159008 0.0127438113463991 miRNATAP -0.237528056213487 0.00153215444016214 NA NA NA hsa-miR-330-3p PIK3R1 2.49094236945806 0.000129367003214715 -1.85375256159008 0.0127438113463991 MirTarget;PITA;miRNATAP -0.222421511130143 0.000560333266659095 NA NA NA hsa-miR-335-3p PIK3R1 1.19503568251824 0.0938852560631551 -1.85375256159008 0.0127438113463991 mirMAP -0.187424798668302 0.00154671007013318 NA NA NA hsa-miR-338-5p PIK3R1 -0.108304629897487 0.894675560494607 -1.85375256159008 0.0127438113463991 PITA -0.149038254580324 0.00415133065382571 NA NA NA hsa-miR-582-5p PIK3R1 0.685177900016753 0.447761540297692 -1.85375256159008 0.0127438113463991 mirMAP -0.168928206892885 0.000293205730117536 NA NA NA hsa-miR-584-5p PIK3R1 1.17912816682866 0.202862496863776 -1.85375256159008 0.0127438113463991 mirMAP -0.264485629334745 3.0909574049315e-09 NA NA NA hsa-miR-590-5p PIK3R1 1.51400888103768 0.0023888567923017 -1.85375256159008 0.0127438113463991 MirTarget;PITA;miRanda;miRNATAP -0.297003967343676 0.000452335914243657 NA NA NA hsa-miR-629-3p PIK3R1 3.48282157979573 4.9176538695908e-08 -1.85375256159008 0.0127438113463991 MirTarget -0.21216292379107 0.00105654186835094 NA NA NA hsa-miR-1271-5p PIK3R3 0.212382644103427 0.742544160267329 -0.029728653396571 0.959330193755408 mirMAP -0.151933011438603 0.00299533512999816 NA NA NA hsa-miR-18a-3p PIK3R3 3.64944956993027 7.20156641833731e-07 -0.029728653396571 0.959330193755408 miRNAWalker2_validate -0.172437749406846 8.76134189601592e-05 NA NA NA hsa-miR-222-5p PIK3R3 2.52056758362407 0.00142010793166944 -0.029728653396571 0.959330193755408 mirMAP -0.169591357898129 3.80520658072856e-05 NA NA NA hsa-miR-29b-1-5p PIK3R3 0.33698032160171 0.598092174563471 -0.029728653396571 0.959330193755408 mirMAP -0.214703534793861 3.15537480066889e-05 NA NA NA hsa-miR-330-3p PIK3R3 2.49094236945806 0.000129367003214715 -0.029728653396571 0.959330193755408 MirTarget -0.191183653307302 0.000135580399986553 NA NA NA hsa-miR-330-5p PIK3R3 2.25110496739954 0.000275527655397415 -0.029728653396571 0.959330193755408 miRanda -0.158989578902319 0.00262587059425892 NA NA NA hsa-miR-365a-3p PIK3R3 0.25545896241765 0.654320504621012 -0.029728653396571 0.959330193755408 MirTarget -0.330277583325266 6.38384266733533e-09 NA NA NA hsa-miR-511-5p PIK3R3 1.10428503984162 0.179276103915417 -0.029728653396571 0.959330193755408 MirTarget -0.179185145111208 6.38466351145281e-06 25608840 MiR 511 inhibits growth and metastasis of human hepatocellular carcinoma cells by targeting PIK3R3; We further demonstrated that miR-511 suppressed HCC cell proliferation migration and invasion by repressing PIK3R3 expression metastasis liver cancer hsa-miR-590-5p PIK3R3 1.51400888103768 0.0023888567923017 -0.029728653396571 0.959330193755408 miRanda -0.195493025557274 0.00311783468590026 NA NA NA hsa-miR-125a-3p PIK3R5 -0.0748960586927341 0.920735897434087 0.75811064163987 0.286920846128457 miRanda -0.143772140191083 0.00747323319002246 NA NA NA hsa-miR-125a-5p PIK3R5 -1.32352790615388 0.00714301627309467 0.75811064163987 0.286920846128457 MirTarget;miRanda -0.250957855170204 0.00223286885929377 NA NA NA hsa-miR-182-5p PIK3R5 5.86988712704738 1.22411588571584e-15 0.75811064163987 0.286920846128457 MirTarget -0.25329203027594 9.2894340160784e-07 NA NA NA hsa-let-7g-3p PIM1 2.09736290930341 5.30067796437833e-05 -0.400917529717717 0.511269428175032 miRNATAP -0.22818922154225 0.00053835393993233 NA NA NA hsa-miR-125a-5p PIM1 -1.32352790615388 0.00714301627309467 -0.400917529717717 0.511269428175032 miRanda -0.282181863465199 5.42107722103925e-05 NA NA NA hsa-miR-183-5p PIM1 6.61903249270777 1.00958881445636e-16 -0.400917529717717 0.511269428175032 miRNATAP -0.136326199839447 0.0008656313128994 NA NA NA hsa-miR-186-5p PIM1 0.445443449112564 0.185447310527704 -0.400917529717717 0.511269428175032 mirMAP -0.442976408202333 2.1078894379751e-05 NA NA NA hsa-miR-192-5p PIM1 1.77716187978541 0.113485496183047 -0.400917529717717 0.511269428175032 miRNAWalker2_validate -0.23590961044581 7.51472162756641e-16 NA NA NA hsa-miR-215-5p PIM1 3.66990923176752 0.00294614570694381 -0.400917529717717 0.511269428175032 miRNAWalker2_validate -0.157484186901436 6.92974241599365e-09 NA NA NA hsa-miR-335-5p PIM1 0.167216045757305 0.803897055331049 -0.400917529717717 0.511269428175032 miRNAWalker2_validate -0.16786242328842 0.00106376482453832 NA NA NA hsa-miR-429 PIM1 6.39965293994036 1.96920201593608e-18 -0.400917529717717 0.511269428175032 miRNATAP -0.137917284278146 0.00192847901609067 NA NA NA hsa-miR-532-3p PIM1 0.643755490841218 0.214842585969913 -0.400917529717717 0.511269428175032 miRNATAP -0.330842491310798 5.39758885807082e-07 NA NA NA hsa-miR-616-5p PIM1 2.48416313933027 0.00318247475868827 -0.400917529717717 0.511269428175032 mirMAP -0.240367358771737 1.97012366569021e-06 NA NA NA hsa-miR-769-3p PIM1 1.74947739956763 0.0310790621215023 -0.400917529717717 0.511269428175032 PITA -0.160519816406477 0.00202091480373551 NA NA NA hsa-let-7a-3p PRLR 0.82512001802525 0.0468122405194487 -5.28037380437679 0.000876404303480571 mirMAP -0.842138069892473 0.000126621309469784 NA NA NA hsa-let-7d-5p PRLR 0.831142050231414 0.0126955498524287 -5.28037380437679 0.000876404303480571 miRNATAP -0.930491683982486 0.000766642240170437 NA NA NA hsa-let-7f-1-3p PRLR 1.61507869803314 0.00069342464777815 -5.28037380437679 0.000876404303480571 mirMAP -0.816039096488304 1.7189814301318e-05 NA NA NA hsa-miR-103a-2-5p PRLR 2.77240253557299 0.000302548514615442 -5.28037380437679 0.000876404303480571 mirMAP -0.352698569249809 0.0029177555286185 NA NA NA hsa-miR-130a-3p PRLR 0.176861046122832 0.7577473016872 -5.28037380437679 0.000876404303480571 mirMAP -0.493070459822395 0.00189826933109988 NA NA NA hsa-miR-142-3p PRLR 4.35304505457969 3.10014573651358e-10 -5.28037380437679 0.000876404303480571 PITA;miRNATAP -0.338297209876975 0.00791744122447048 NA NA NA hsa-miR-15b-3p PRLR 3.57530146629867 5.89922785773482e-11 -5.28037380437679 0.000876404303480571 mirMAP -0.593478840866584 0.000220832631914752 NA NA NA hsa-miR-19b-1-5p PRLR 1.51335451095424 0.0014717605268143 -5.28037380437679 0.000876404303480571 mirMAP -0.675561023319356 0.000380483040108734 NA NA NA hsa-miR-20a-3p PRLR 1.9920766549842 0.000624458530894697 -5.28037380437679 0.000876404303480571 mirMAP -0.593345559646597 0.00011868945416843 NA NA NA hsa-miR-22-5p PRLR 2.38337850108621 1.0773503998394e-05 -5.28037380437679 0.000876404303480571 mirMAP -0.672975889551064 4.4066900239266e-05 NA NA NA hsa-miR-32-3p PRLR 2.20477794939766 0.0392771274032852 -5.28037380437679 0.000876404303480571 mirMAP -0.474650592165327 0.0014560346864996 NA NA NA hsa-miR-320b PRLR 0.20205459771295 0.727216419960509 -5.28037380437679 0.000876404303480571 miRanda -0.411977816204814 0.00889879225481238 NA NA NA hsa-miR-330-3p PRLR 2.49094236945806 0.000129367003214715 -5.28037380437679 0.000876404303480571 mirMAP;miRNATAP -0.581097580918294 2.36835535566655e-05 NA NA NA hsa-miR-33a-3p PRLR 2.06269680799532 0.00156436055383943 -5.28037380437679 0.000876404303480571 mirMAP -0.465474654123544 0.000786719970127142 NA NA NA hsa-miR-34c-5p PRLR 2.64675661251039 0.0157394735757952 -5.28037380437679 0.000876404303480571 miRanda;miRNATAP -0.232656206445797 0.0047193060370075 NA NA NA hsa-miR-3614-5p PRLR 4.50236405439456 2.75644515847367e-07 -5.28037380437679 0.000876404303480571 mirMAP -0.293570646395737 0.00391772270226576 NA NA NA hsa-miR-421 PRLR 1.97624148591545 0.000915838012451138 -5.28037380437679 0.000876404303480571 miRanda;mirMAP;miRNATAP -0.414314425852899 0.00642307231365017 NA NA NA hsa-miR-582-5p PRLR 0.685177900016753 0.447761540297692 -5.28037380437679 0.000876404303480571 PITA -0.26341521675333 0.0087427572780806 NA NA NA hsa-miR-9-3p PRLR 1.69328215716742 0.125170982657059 -5.28037380437679 0.000876404303480571 mirMAP -0.227290062681084 0.00630468933586122 NA NA NA hsa-miR-9-5p PRLR 1.79620806707734 0.14526963042518 -5.28037380437679 0.000876404303480571 miRNATAP -0.228612549871601 0.00177060824316513 NA NA NA hsa-miR-944 PRLR 7.20925181386398 0.000823207457340648 -5.28037380437679 0.000876404303480571 mirMAP -0.349135456877722 3.36718908955124e-12 NA NA NA hsa-miR-590-3p PTPN11 2.35429565068338 2.79601879608564e-06 -0.26881663064581 0.41011535095971 PITA;miRanda;mirMAP;miRNATAP -0.110948394627863 0.00216694766131181 NA NA NA hsa-miR-107 SOCS2 1.49443409571439 0.000130594521065411 -3.75280768329564 6.02271766690472e-06 miRanda -0.392706705310798 0.00134286317048738 NA NA NA hsa-miR-130b-5p SOCS2 3.74118449312296 2.92266550966038e-10 -3.75280768329564 6.02271766690472e-06 miRNATAP -0.363364726264855 2.61190615149405e-06 NA NA NA hsa-miR-16-1-3p SOCS2 2.83281226969693 7.54359864580834e-09 -3.75280768329564 6.02271766690472e-06 mirMAP -0.295573312574332 0.00195499139730453 NA NA NA hsa-miR-16-5p SOCS2 2.93575808220754 2.15436817162977e-10 -3.75280768329564 6.02271766690472e-06 miRNAWalker2_validate -0.378839484095042 0.000161569066512098 NA NA NA hsa-miR-186-5p SOCS2 0.445443449112564 0.185447310527704 -3.75280768329564 6.02271766690472e-06 mirMAP -0.444678168701268 0.00215656027774561 NA NA NA hsa-miR-19b-3p SOCS2 1.67581705793313 0.000858910586302716 -3.75280768329564 6.02271766690472e-06 mirMAP -0.269773541876799 0.00443538562239262 NA NA NA hsa-miR-25-3p SOCS2 1.12623030168869 0.00311079344417173 -3.75280768329564 6.02271766690472e-06 mirMAP -0.409908348787947 0.00117536021875763 NA NA NA hsa-miR-324-5p SOCS2 1.31253452379847 0.0116806680545163 -3.75280768329564 6.02271766690472e-06 miRanda -0.333686124329515 0.00026433969831329 NA NA NA hsa-miR-363-3p SOCS2 4.27232887548977 8.53979362839458e-06 -3.75280768329564 6.02271766690472e-06 mirMAP -0.252639336614082 1.58476426290123e-07 NA NA NA hsa-miR-429 SOCS2 6.39965293994036 1.96920201593608e-18 -3.75280768329564 6.02271766690472e-06 miRNATAP -0.363055952071184 1.58048906622716e-09 NA NA NA hsa-miR-940 SOCS2 3.78496690968119 4.75227557809023e-05 -3.75280768329564 6.02271766690472e-06 miRNATAP -0.168726756897247 0.00655274423052111 NA NA NA hsa-miR-130b-5p SOCS3 3.74118449312296 2.92266550966038e-10 -1.34247753027862 0.0584354836971487 mirMAP -0.230083563549641 0.000466452084019066 NA NA NA hsa-miR-508-3p SOCS3 0.975099105064348 0.439528954969797 -1.34247753027862 0.0584354836971487 PITA -0.102810534583983 0.00137168684303789 NA NA NA hsa-miR-374b-5p SOCS4 -0.114749866169918 0.764888930049438 0.555494689210945 0.0465614251417991 mirMAP;miRNATAP -0.108355306256051 0.00943455300270299 NA NA NA hsa-miR-21-5p SOCS5 2.65163477806992 6.72089787690756e-16 -1.13398715696047 0.000287928413880305 miRNAWalker2_validate -0.193685843333829 0.000218350167881486 NA NA NA hsa-miR-342-3p SOCS5 1.31107714473009 0.0207211910724662 -1.13398715696047 0.000287928413880305 miRanda -0.125391676598967 5.84966391472127e-05 NA NA NA hsa-miR-590-3p SOCS5 2.35429565068338 2.79601879608564e-06 -1.13398715696047 0.000287928413880305 miRanda;mirMAP -0.116155991839947 0.000892753536899172 NA NA NA hsa-miR-145-5p SOCS7 -3.55505374822025 5.45525288912869e-07 0.795316016915517 0.230711277503264 miRNAWalker2_validate -0.161087905425991 0.00191905942013873 23392170 socs7 a target gene of microRNA 145 regulates interferon β induction through STAT3 nuclear translocation in bladder cancer cells; Then we focused on the suppressor of cytokine signaling 7 socs7 whose expression level was upregulated in bladder cancer cells compared with its level in normal human urothelial cells as a putative target gene involved in IFN-β induction by miR-145; Expectedly exogenous miR-145 decreased the expression level of SOCS7 and socs7-silencing enhanced IFN-β induction by transfection with a TLR3 ligand polyinosinic acid-polycytidylic acid PIC; The results of a luciferase reporter assay revealed that miR-145 targeted socs7; In conclusion the machinery of IFN-β induction through the regulation of SOCS7 by miR-145 was closely associated with the induction of apoptosis; Moreover exogenous miR-145 promoted IFN-β induction by targeting socs7 which resulted in the nuclear translocation of STAT3 bladder cancer hsa-miR-320a SOCS7 -0.912036444869976 0.0565555443926988 0.795316016915517 0.230711277503264 PITA;miRanda -0.219870316379093 0.00544090577724396 NA NA NA hsa-miR-30b-5p SOS1 0.0238659735605804 0.953223658270319 -0.317916313975443 0.241700272513698 mirMAP -0.108560527488227 0.00434235766945579 NA NA NA hsa-miR-339-5p SOS1 1.23326828594484 0.0307501214818698 -0.317916313975443 0.241700272513698 miRNATAP -0.123853061266441 2.87456784370318e-06 NA NA NA hsa-let-7a-3p SOS2 0.82512001802525 0.0468122405194487 -0.267591445900317 0.496928330255155 miRNATAP -0.164368847616136 0.00237247406832302 NA NA NA hsa-miR-193a-3p SOS2 0.646392169474854 0.207134343676122 -0.267591445900317 0.496928330255155 PITA;miRanda;miRNATAP -0.120918057682943 0.00561915694088728 NA NA NA hsa-miR-590-3p SOS2 2.35429565068338 2.79601879608564e-06 -0.267591445900317 0.496928330255155 miRanda;mirMAP -0.188531608844422 1.41164746076931e-05 NA NA NA hsa-miR-590-5p SOS2 1.51400888103768 0.0023888567923017 -0.267591445900317 0.496928330255155 PITA;miRanda;miRNATAP -0.17241746507823 0.000101790255421271 NA NA NA hsa-miR-141-3p SPRED1 7.30474126597325 1.45115996357606e-24 -1.20771019802783 0.00430481333608872 miRNATAP -0.141546148382713 4.07396380225223e-06 NA NA NA hsa-miR-16-1-3p SPRED1 2.83281226969693 7.54359864580834e-09 -1.20771019802783 0.00430481333608872 mirMAP -0.169376267820922 0.000412743353675351 NA NA NA hsa-miR-200c-3p SPRED1 6.47012025883743 2.64500707716408e-26 -1.20771019802783 0.00430481333608872 miRNATAP -0.151820076292416 2.37878276088673e-05 NA NA NA hsa-miR-20a-5p SPRED1 2.13553469875764 0.000181201072324354 -1.20771019802783 0.00430481333608872 miRNATAP -0.124282508322772 0.00298102385601219 NA NA NA hsa-miR-224-5p SPRED1 4.2725754042941 6.99983365278436e-06 -1.20771019802783 0.00430481333608872 mirMAP -0.106457805694447 1.5472738228399e-05 NA NA NA hsa-miR-33a-3p SPRED1 2.06269680799532 0.00156436055383943 -1.20771019802783 0.00430481333608872 mirMAP -0.104220355238502 0.00466702372620088 NA NA NA hsa-miR-142-5p SPRED2 3.95552531913424 1.49536283724079e-08 -0.90259077923118 0.1010080763787 mirMAP -0.200771220304438 3.19189109878961e-06 NA NA NA hsa-miR-146b-5p SPRED2 1.87569569182453 0.000737241069698886 -0.90259077923118 0.1010080763787 miRanda -0.255301156210791 3.92265305503982e-06 NA NA NA hsa-miR-142-5p SPRY1 3.95552531913424 1.49536283724079e-08 -3.2710013892746 9.11497674299647e-06 miRNATAP -0.301966260107769 2.27796900649466e-07 NA NA NA hsa-miR-16-2-3p SPRY1 3.79845098071094 1.49120139344659e-13 -3.2710013892746 9.11497674299647e-06 mirMAP -0.528857483020798 6.57440746821615e-12 NA NA NA hsa-miR-20a-3p SPRY1 1.9920766549842 0.000624458530894697 -3.2710013892746 9.11497674299647e-06 miRNATAP -0.271026257462462 0.000169955358456916 NA NA NA hsa-miR-21-5p SPRY1 2.65163477806992 6.72089787690756e-16 -3.2710013892746 9.11497674299647e-06 miRNATAP -0.54085988562774 1.3604058677687e-05 24155920 Functional studies showed that miR-21 over-expression in GICs induced comparable cell differentiation features and targeted SPRY1 mRNA which encodes for a negative regulator of neural stem-cell differentiation differentiation glioblastoma hsa-miR-29b-3p SPRY1 0.666547117072858 0.234055379278093 -3.2710013892746 9.11497674299647e-06 miRNATAP -0.310844047213727 3.79563044528277e-05 NA NA NA hsa-miR-339-5p SPRY1 1.23326828594484 0.0307501214818698 -3.2710013892746 9.11497674299647e-06 miRanda -0.314442819460592 2.00530349828149e-05 NA NA NA hsa-miR-34c-5p SPRY1 2.64675661251039 0.0157394735757952 -3.2710013892746 9.11497674299647e-06 miRanda -0.152176287682728 6.88820122297656e-05 NA NA NA hsa-miR-3615 SPRY1 2.00888751637278 0.000397875472856691 -3.2710013892746 9.11497674299647e-06 miRNAWalker2_validate -0.358186964642344 1.06611836429763e-06 NA NA NA hsa-miR-550a-3p SPRY1 2.59872127213466 0.00155498164206068 -3.2710013892746 9.11497674299647e-06 miRNATAP -0.230273800473593 0.000238507518279455 NA NA NA hsa-miR-590-5p SPRY1 1.51400888103768 0.0023888567923017 -3.2710013892746 9.11497674299647e-06 PITA;miRanda;miRNATAP -0.380981579223777 6.09914437614703e-06 NA NA NA hsa-miR-98-5p SPRY1 0.80703717290679 0.030235891695826 -3.2710013892746 9.11497674299647e-06 miRNAWalker2_validate -0.317816042386101 0.00595110667288046 NA NA NA hsa-miR-130a-5p SPRY2 1.58028512890005 0.024346333013728 -1.84053927439631 0.0157145497129286 miRNATAP -0.188217073534112 0.00267243332897753 NA NA NA hsa-miR-21-5p SPRY2 2.65163477806992 6.72089787690756e-16 -1.84053927439631 0.0157145497129286 miRNAWalker2_validate;miRTarBase;miRNATAP -0.46955875121018 0.000234633397177895 22322462 Inhibition of microRNA-21 mir‑21 induced upregulation of Spry2 and PTEN which underscores the importance of mir-21 in Spry2-associated tumorigenesis of the colon tumorigenesis colon cancer hsa-miR-23a-3p SPRY2 0.925125296618358 0.0127293543936914 -1.84053927439631 0.0157145497129286 miRNATAP -0.396337883995599 0.000780423560199048 NA NA NA hsa-miR-27a-3p SPRY2 1.76094007417453 0.000216137556256765 -1.84053927439631 0.0157145497129286 miRNAWalker2_validate;miRTarBase;miRNATAP -0.408141274363688 5.69419583192629e-06 20638779 By using a reporter-screening assay we discovered that the 3'UTR of Sprouty2 Spry2 carried a putative miR-27a binding site; Furthermore the Spry2 protein which has a low expression level in pancreatic adenocarcinoma was upregulated by transfection with a miR-27a inhibitor; The data reported here are the first to indicate that miR-27a plays an oncogenic role by targeting Spry2 and modulating the malignant biological behavior of pancreatic cancer cells malignant trasformation pancreatic cancer hsa-miR-330-5p SPRY2 2.25110496739954 0.000275527655397415 -1.84053927439631 0.0157145497129286 miRanda;miRNATAP -0.255601489387552 0.000221127499087162 NA NA NA hsa-miR-452-5p SPRY2 2.45466810475361 0.00114794259949532 -1.84053927439631 0.0157145497129286 miRNATAP -0.299283104207563 9.18727013659553e-08 NA NA NA hsa-miR-590-3p SPRY2 2.35429565068338 2.79601879608564e-06 -1.84053927439631 0.0157145497129286 PITA;miRanda;mirMAP;miRNATAP -0.33135612587349 9.47531848533949e-05 NA NA NA hsa-miR-590-5p SPRY2 1.51400888103768 0.0023888567923017 -1.84053927439631 0.0157145497129286 PITA;miRanda;miRNATAP -0.253568686319253 0.00353988276981177 NA NA NA hsa-let-7a-3p SPRY3 0.82512001802525 0.0468122405194487 -0.618370143930133 0.359933803484397 MirTarget;mirMAP -0.277684247517876 0.00284827985589076 NA NA NA hsa-let-7f-1-3p SPRY3 1.61507869803314 0.00069342464777815 -0.618370143930133 0.359933803484397 MirTarget;mirMAP -0.355011337706502 8.99889614144522e-06 NA NA NA hsa-miR-1271-5p SPRY3 0.212382644103427 0.742544160267329 -0.618370143930133 0.359933803484397 MirTarget -0.181878586357806 0.00217980449351526 NA NA NA hsa-miR-142-3p SPRY3 4.35304505457969 3.10014573651358e-10 -0.618370143930133 0.359933803484397 miRanda -0.178441097360108 0.000858276845345095 NA NA NA hsa-miR-146a-5p SPRY3 2.64646698525354 0.000280611928973036 -0.618370143930133 0.359933803484397 mirMAP -0.135073941470904 0.0094682511102251 NA NA NA hsa-miR-155-5p SPRY3 2.81443182173772 7.42530504828797e-05 -0.618370143930133 0.359933803484397 mirMAP -0.276563743066389 1.30689728616715e-07 NA NA NA hsa-miR-15b-3p SPRY3 3.57530146629867 5.89922785773482e-11 -0.618370143930133 0.359933803484397 mirMAP -0.178828419864989 0.00865010491618416 NA NA NA hsa-miR-21-3p SPRY3 3.50297439576639 6.39946844099206e-10 -0.618370143930133 0.359933803484397 mirMAP -0.351514935845698 5.36411571136968e-08 NA NA NA hsa-miR-296-5p SPRY3 0.177244733354615 0.848499862912268 -0.618370143930133 0.359933803484397 miRNATAP -0.149583662842586 0.000296836099988239 NA NA NA hsa-miR-330-3p SPRY3 2.49094236945806 0.000129367003214715 -0.618370143930133 0.359933803484397 mirMAP;miRNATAP -0.225841308457804 0.000101148583220006 NA NA NA hsa-miR-330-5p SPRY3 2.25110496739954 0.000275527655397415 -0.618370143930133 0.359933803484397 miRNATAP -0.262079016579601 1.64630411746947e-05 NA NA NA hsa-miR-3653-3p SPRY3 2.32416512605984 0.000268136992079666 -0.618370143930133 0.359933803484397 MirTarget -0.219020497358926 0.000223160573576684 NA NA NA hsa-miR-455-3p SPRY3 2.1864857056272 0.00137304627957677 -0.618370143930133 0.359933803484397 miRNATAP -0.143598457496027 0.00992541150094292 NA NA NA hsa-miR-590-3p SPRY3 2.35429565068338 2.79601879608564e-06 -0.618370143930133 0.359933803484397 mirMAP -0.196900406235287 0.00904428657062882 NA NA NA hsa-miR-708-3p SPRY3 0.781444321399141 0.290645825716608 -0.618370143930133 0.359933803484397 MirTarget;mirMAP -0.177471728870821 0.000577988245263235 NA NA NA hsa-miR-708-5p SPRY3 1.70409736218557 0.0319538709865338 -0.618370143930133 0.359933803484397 MirTarget -0.191113856675838 6.07876559503692e-05 NA NA NA hsa-miR-944 SPRY3 7.20925181386398 0.000823207457340648 -0.618370143930133 0.359933803484397 mirMAP -0.173011737776688 9.01075907353884e-17 NA NA NA hsa-miR-142-5p SPRY4 3.95552531913424 1.49536283724079e-08 -1.47925433496862 0.0430344985688012 mirMAP -0.294816562464616 2.48737143373938e-07 NA NA NA hsa-miR-16-2-3p SPRY4 3.79845098071094 1.49120139344659e-13 -1.47925433496862 0.0430344985688012 mirMAP -0.318380777583772 3.78366678505134e-05 NA NA NA hsa-miR-16-5p SPRY4 2.93575808220754 2.15436817162977e-10 -1.47925433496862 0.0430344985688012 miRNATAP -0.250752910467788 0.00428026678845028 NA NA NA hsa-miR-29b-3p SPRY4 0.666547117072858 0.234055379278093 -1.47925433496862 0.0430344985688012 miRNATAP -0.249927327078422 0.00076026049416906 NA NA NA hsa-miR-29c-3p SPRY4 -0.414153610337085 0.529344128062017 -1.47925433496862 0.0430344985688012 miRNATAP -0.379967040609179 7.29988090898489e-10 NA NA NA hsa-miR-320c SPRY4 -0.10618808730545 0.854002814666472 -1.47925433496862 0.0430344985688012 mirMAP -0.202800579742496 0.00590089801424927 NA NA NA hsa-miR-34c-3p SPRY4 4.0411891981675 0.000195495966405666 -1.47925433496862 0.0430344985688012 PITA -0.156875154481034 3.19669276178902e-05 NA NA NA hsa-miR-361-3p SPRY4 0.805698609170807 0.0418491665498322 -1.47925433496862 0.0430344985688012 miRNATAP -0.388477229553273 0.00023732134943685 NA NA NA hsa-miR-452-3p SPRY4 2.97956996345436 0.000203580834647624 -1.47925433496862 0.0430344985688012 mirMAP -0.192819210251523 0.000160915576011721 NA NA NA hsa-miR-944 SPRY4 7.20925181386398 0.000823207457340648 -1.47925433496862 0.0430344985688012 PITA;mirMAP;miRNATAP -0.151190572611104 5.42543974620987e-11 NA NA NA hsa-miR-146b-5p STAM2 1.87569569182453 0.000737241069698886 -0.23218158409261 0.411981092016444 miRanda -0.111743465233449 8.08337006838149e-05 NA NA NA hsa-miR-20a-3p STAM2 1.9920766549842 0.000624458530894697 -0.23218158409261 0.411981092016444 MirTarget -0.10460240864773 0.000108981396599193 NA NA NA hsa-miR-92a-3p STAM2 1.87892405805529 1.27013821556583e-05 -0.23218158409261 0.411981092016444 mirMAP -0.102683949267686 0.00532917523579539 NA NA NA hsa-miR-129-5p STAT1 -2.66843722411409 0.00695783358331245 2.01274955437017 0.00163940367755263 miRanda -0.132968133978279 0.000332779406279412 NA NA NA hsa-miR-143-5p STAT1 -1.23893144572919 0.0631644173977607 2.01274955437017 0.00163940367755263 MirTarget -0.278466307388879 2.29950756322775e-07 NA NA NA hsa-miR-145-5p STAT1 -3.55505374822025 5.45525288912869e-07 2.01274955437017 0.00163940367755263 miRNAWalker2_validate;miRTarBase -0.301283748877802 9.42789762512279e-10 20098684 MicroRNA 145 targets YES and STAT1 in colon cancer cells; Both YES and STAT1 were verified as direct miR-145 targets colon cancer hsa-miR-182-5p STAT1 5.86988712704738 1.22411588571584e-15 2.01274955437017 0.00163940367755263 mirMAP -0.141741106320013 0.00269792907366131 NA NA NA hsa-miR-30c-2-3p STAT1 -0.916427677918778 0.300195789569016 2.01274955437017 0.00163940367755263 MirTarget -0.168573272016947 3.67612990391486e-05 NA NA NA hsa-miR-34a-5p STAT1 0.830377770217786 0.0477544831885907 2.01274955437017 0.00163940367755263 miRNAWalker2_validate -0.269576975538692 0.00211365779456242 NA NA NA hsa-miR-361-5p STAT1 0.00649167180664723 0.985202350239079 2.01274955437017 0.00163940367755263 miRanda -0.463679155021812 1.101952208681e-05 NA NA NA hsa-miR-495-3p STAT1 -1.28495103468384 0.0979462503954353 2.01274955437017 0.00163940367755263 MirTarget -0.167329201002395 0.000346028566784044 NA NA NA hsa-miR-532-3p STAT1 0.643755490841218 0.214842585969913 2.01274955437017 0.00163940367755263 MirTarget -0.236799777603778 0.000777789771112861 NA NA NA hsa-miR-96-5p STAT1 5.62521466029286 1.54938806718028e-10 2.01274955437017 0.00163940367755263 mirMAP -0.211622398008511 1.44467949291041e-05 NA NA NA hsa-miR-335-5p STAT2 0.167216045757305 0.803897055331049 0.867646241695998 0.0419134711672987 miRNAWalker2_validate -0.100797534173916 0.00505999447261084 NA NA NA hsa-miR-339-5p STAT2 1.23326828594484 0.0307501214818698 0.867646241695998 0.0419134711672987 miRanda -0.109661316007533 0.00972781086346445 NA NA NA hsa-miR-432-5p STAT2 -1.04688139137176 0.21678663577335 0.867646241695998 0.0419134711672987 MirTarget -0.129653971260457 5.15928370583859e-06 NA NA NA hsa-miR-106b-5p STAT3 2.80565545918114 1.14547999022566e-09 0.0160861395507963 0.957262386811393 miRNATAP -0.109483404039862 0.00226965981619241 27325313 We also found that EMMPRIN could down-regulate miR-106a and miR-106b expression in breast cancer cells which led to activating STAT3 and enhancing HIF-1α expression breast cancer hsa-miR-320b STAT3 0.20205459771295 0.727216419960509 0.0160861395507963 0.957262386811393 miRanda -0.112145780614318 0.000117337048085059 NA NA NA hsa-miR-590-5p STAT3 1.51400888103768 0.0023888567923017 0.0160861395507963 0.957262386811393 miRanda;miRNATAP -0.111984699334191 0.000922243125456699 27757042 We found that the AKT/ERK and STAT3 signaling pathways were activated by miR-590-5p overexpression gastric cancer hsa-miR-93-5p STAT3 2.65964181833033 2.58315947526774e-08 0.0160861395507963 0.957262386811393 miRNAWalker2_validate;miRNATAP -0.109567101305833 0.00160117146509212 NA NA NA hsa-miR-125a-5p STAT4 -1.32352790615388 0.00714301627309467 0.443436361011697 0.561800373574938 miRanda -0.241368232569383 0.0062185428292532 NA NA NA hsa-miR-200a-3p STAT4 6.336081120041 4.024313571871e-16 0.443436361011697 0.561800373574938 MirTarget -0.282709613251881 4.93960842326004e-08 NA NA NA hsa-miR-141-3p STAT5A 7.30474126597325 1.45115996357606e-24 -0.717676705261435 0.218333398036409 MirTarget;TargetScan;miRNATAP -0.126784354708193 0.0029270777747242 25241899 Progesterone downregulation of miR 141 contributes to expansion of stem like breast cancer cells through maintenance of progesterone receptor and Stat5a; miR-141 directly targeted both PR and signal transducer and activator of transcription 5A Stat5a transcription factors important for MaSC expansion; These data support a mechanism by which P4-triggered loss of miR-141 facilitates breast cancer cell de-differentiation through deregulation of PR and Stat5a two transcription factors important for controlling mammary cell fate differentiation breast cancer hsa-miR-200a-3p STAT5A 6.336081120041 4.024313571871e-16 -0.717676705261435 0.218333398036409 MirTarget;miRNATAP -0.128916767921046 0.00133172867013861 NA NA NA hsa-miR-421 STAT5A 1.97624148591545 0.000915838012451138 -0.717676705261435 0.218333398036409 miRanda -0.240163523581156 1.1727249565903e-05 NA NA NA hsa-miR-589-3p STAT5A 1.33205316880069 0.052632683806148 -0.717676705261435 0.218333398036409 mirMAP -0.225079983070066 2.42090016570763e-06 NA NA NA hsa-miR-125a-3p STAT5B -0.0748960586927341 0.920735897434087 -2.15100735109765 1.31811971048943e-10 miRanda -0.102157192142955 7.54164641040137e-05 NA NA NA hsa-miR-141-3p STAT5B 7.30474126597325 1.45115996357606e-24 -2.15100735109765 1.31811971048943e-10 MirTarget;TargetScan;miRNATAP -0.152354505690987 5.64820480890233e-10 NA NA NA hsa-miR-200a-3p STAT5B 6.336081120041 4.024313571871e-16 -2.15100735109765 1.31811971048943e-10 MirTarget;miRNATAP -0.140099562865409 1.63595175829897e-09 NA NA NA hsa-miR-21-3p STAT5B 3.50297439576639 6.39946844099206e-10 -2.15100735109765 1.31811971048943e-10 MirTarget -0.123689092056195 0.000210151932233511 NA NA NA hsa-miR-324-3p STAT5B 1.51345381556672 0.0038447546677657 -2.15100735109765 1.31811971048943e-10 miRNAWalker2_validate -0.122406653160063 0.000986101861639943 NA NA NA hsa-miR-590-3p STAT5B 2.35429565068338 2.79601879608564e-06 -2.15100735109765 1.31811971048943e-10 miRanda -0.134471400262777 0.00044340928898596 NA NA NA hsa-miR-93-3p STAT5B 2.62833115374128 2.28843227834337e-07 -2.15100735109765 1.31811971048943e-10 miRNAWalker2_validate -0.197244367758832 1.17533780050923e-07 NA NA NA hsa-miR-107 STAT6 1.49443409571439 0.000130594521065411 -0.341889129772087 0.314047224536931 miRanda -0.213139283219566 1.24319501834389e-05 NA NA NA hsa-miR-361-5p STAT6 0.00649167180664723 0.985202350239079 -0.341889129772087 0.314047224536931 miRanda -0.15943041660543 0.00434119007219543 NA NA NA hsa-miR-125a-5p TSLP -1.32352790615388 0.00714301627309467 -0.473304789058878 0.750085363109198 miRanda -0.56789080130545 0.000905180332444997 NA NA NA hsa-miR-338-3p TSLP 0.447551118940466 0.558485097370031 -0.473304789058878 0.750085363109198 miRanda -0.604404058673497 2.22442016292586e-08 NA NA NA