miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-15b-3p ABL1 3.57530146629867 5.89922785773482e-11 -1.71762983287229 3.75044691377874e-07 MirTarget -0.130238515032693 0.000154491957774896 NA NA NA hsa-miR-15b-5p ABL1 3.32329949959268 8.40210501034588e-13 -1.71762983287229 3.75044691377874e-07 mirMAP -0.106769937878675 0.0085448676446359 NA NA NA hsa-miR-16-5p ABL1 2.93575808220754 2.15436817162977e-10 -1.71762983287229 3.75044691377874e-07 mirMAP -0.109905141068799 0.00756278893228814 NA NA NA hsa-miR-30e-5p ABL1 0.780047227271616 0.0346714425913016 -1.71762983287229 3.75044691377874e-07 MirTarget;miRNATAP -0.17773103737115 0.000859685989830285 NA NA NA hsa-miR-203a-3p ATM 6.35084246337388 7.89944323347948e-08 -0.658961239426083 0.11688259993407 MirTarget -0.10711538788314 2.54510630277939e-08 24145123;27542403 miR 203 induces oxaliplatin resistance in colorectal cancer cells by negatively regulating ATM kinase; In silico analysis identified ataxia telangiectasia mutated ATM a primary mediator of the DNA damage response as a potential target of miR-203; Using TCGA database we identified a significant reverse correlation of miR-203 and ATM expression in CRC tissues; We validated ATM as a bona fide target of miR-203 in CRC cells; Mutation of the putative miR-203 binding site in the 3' untranslated region 3'UTR of the ATM mRNA abolished the inhibitory effect of miR-203 on ATM;MiR 203 inhibits tumor invasion and metastasis in gastric cancer by ATM; Our results showed that miR-203 was significantly downregulated in gastric cancer tissues and cells while ataxia telangiectasia mutated kinase ATM was upregulated in gastric cancer tissues and cells and was directly regulated by miR-203; ATM knockdown phenocopied the effect of miR-203 overexpression drug resistance;metastasis colorectal cancer;gastric cancer hsa-miR-27a-5p ATM 1.44543293228138 0.039420863458837 -0.658961239426083 0.11688259993407 MirTarget -0.118013745915902 0.000461560887135157 NA NA NA hsa-miR-30e-3p ATM -0.0362193022195196 0.932577027239525 -0.658961239426083 0.11688259993407 mirMAP -0.157523794415466 0.00510124349387628 NA NA NA hsa-miR-339-5p ATM 1.23326828594484 0.0307501214818698 -0.658961239426083 0.11688259993407 miRanda -0.155925656284305 0.000170742871820193 NA NA NA hsa-miR-590-5p ATM 1.51400888103768 0.0023888567923017 -0.658961239426083 0.11688259993407 mirMAP -0.134411712770607 0.00484636149427119 NA NA NA hsa-miR-29a-5p ATR 0.0748295222568571 0.884125894063293 1.11653396152035 0.00117645494644219 mirMAP -0.128755734022869 0.000765927974508895 NA NA NA hsa-miR-30a-5p ATR -0.768430903969183 0.320487552854215 1.11653396152035 0.00117645494644219 mirMAP -0.113875244097274 5.31462122478425e-06 NA NA NA hsa-miR-10b-3p BUB1 -2.5229705007884 2.80982573906242e-06 5.49208148866722 2.7147913205372e-40 MirTarget -0.155935673031687 0.00146919699386143 NA NA NA hsa-miR-199a-5p BUB1 -1.24888110793613 0.0747755616523728 5.49208148866722 2.7147913205372e-40 miRanda -0.12118672827533 0.00146037265020973 NA NA NA hsa-miR-199b-5p BUB1 -0.53728867775768 0.476885702455766 5.49208148866722 2.7147913205372e-40 miRanda -0.123529442767038 0.00046958325692232 NA NA NA hsa-miR-30e-5p CCNA1 0.780047227271616 0.0346714425913016 -3.46539887546816 0.0855376559280843 MirTarget -0.992714023601427 0.00158133423436899 NA NA NA hsa-let-7a-5p CCND1 0.148081801547773 0.645305441523746 0.153161422157864 0.87752763573474 TargetScan;miRNATAP -0.543758028087025 0.00245174452713361 NA NA NA hsa-miR-106a-5p CCND1 3.98693608217557 9.37722470816656e-07 0.153161422157864 0.87752763573474 MirTarget;miRNATAP -0.430943892321887 6.82894757639655e-11 NA NA NA hsa-miR-15a-5p CCND1 2.0535411006904 1.91108976398046e-06 0.153161422157864 0.87752763573474 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.345671894500985 0.00776019225008181 22922827 CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR sarcoma hsa-miR-15b-5p CCND1 3.32329949959268 8.40210501034588e-13 0.153161422157864 0.87752763573474 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.423468924188888 0.000292921876666624 NA NA NA hsa-miR-20b-5p CCND1 4.5662923200279 4.75238200639144e-05 0.153161422157864 0.87752763573474 MirTarget;miRNATAP -0.306916825629866 1.73283870424345e-10 NA NA NA hsa-miR-34a-5p CCND1 0.830377770217786 0.0477544831885907 0.153161422157864 0.87752763573474 miRNAWalker2_validate;miRTarBase;miRNATAP -0.423813778518534 0.00174350326234822 25792709;21399894 This inhibition of proliferation was associated with a decrease in cyclin D1 levels orchestrated principally by HNF-4α a target of miR-34a considered to act as a tumour suppressor in the liver;Quantitative PCR and western analysis confirmed decreased expression of two genes BCL-2 and CCND1 in docetaxel-resistant cells which are both targeted by miR-34a ; liver cancer;breast cancer hsa-miR-497-5p CCND1 -1.44150596209372 0.0225146607606395 0.153161422157864 0.87752763573474 MirTarget;miRNATAP -0.249933846887954 0.00498383887238102 21350001 Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer breast cancer hsa-miR-106a-5p CCND2 3.98693608217557 9.37722470816656e-07 -2.81051675901102 0.00139983736368543 miRNATAP -0.444958981451041 2.08537025757115e-14 NA NA NA hsa-miR-106b-5p CCND2 2.80565545918114 1.14547999022566e-09 -2.81051675901102 0.00139983736368543 miRNAWalker2_validate;miRTarBase;miRNATAP -0.309595760343179 0.00374413339981401 NA NA NA hsa-miR-10a-3p CCND2 0.970411431936568 0.31667483998251 -2.81051675901102 0.00139983736368543 mirMAP -0.203238239783698 0.000109626077062705 NA NA NA hsa-miR-130b-5p CCND2 3.74118449312296 2.92266550966038e-10 -2.81051675901102 0.00139983736368543 mirMAP -0.460499923117218 1.14695292180331e-08 NA NA NA hsa-miR-141-3p CCND2 7.30474126597325 1.45115996357606e-24 -2.81051675901102 0.00139983736368543 MirTarget;TargetScan -0.239696704303332 0.000205435786708848 NA NA NA hsa-miR-15b-5p CCND2 3.32329949959268 8.40210501034588e-13 -2.81051675901102 0.00139983736368543 miRNATAP -0.527059068245043 3.31921597840683e-07 NA NA NA hsa-miR-16-2-3p CCND2 3.79845098071094 1.49120139344659e-13 -2.81051675901102 0.00139983736368543 mirMAP -0.289719520581 0.00206680066165107 NA NA NA hsa-miR-182-5p CCND2 5.86988712704738 1.22411588571584e-15 -2.81051675901102 0.00139983736368543 miRNAWalker2_validate;miRTarBase;miRNATAP -0.278474368736704 1.61949004264047e-05 NA NA NA hsa-miR-183-5p CCND2 6.61903249270777 1.00958881445636e-16 -2.81051675901102 0.00139983736368543 miRNATAP -0.288028240113034 1.0097840608077e-06 NA NA NA hsa-miR-191-5p CCND2 1.58824208483839 0.000738859004053681 -2.81051675901102 0.00139983736368543 MirTarget -0.315151097931825 0.00313941450228982 NA NA NA hsa-miR-200a-3p CCND2 6.336081120041 4.024313571871e-16 -2.81051675901102 0.00139983736368543 MirTarget -0.414829241668513 2.52639559759353e-12 NA NA NA hsa-miR-20b-5p CCND2 4.5662923200279 4.75238200639144e-05 -2.81051675901102 0.00139983736368543 miRNATAP -0.295383995634395 4.37719472717441e-12 NA NA NA hsa-miR-224-3p CCND2 2.84876340814503 0.000179138399939161 -2.81051675901102 0.00139983736368543 mirMAP -0.216162489376406 0.00100829595274067 NA NA NA hsa-miR-28-5p CCND2 -0.815636722979196 0.0221199948901761 -2.81051675901102 0.00139983736368543 miRanda -0.428938814049462 0.00272604774130058 NA NA NA hsa-miR-3065-3p CCND2 1.89496019576082 0.0308154823923145 -2.81051675901102 0.00139983736368543 MirTarget;miRNATAP -0.206941274598462 0.000265009133802388 NA NA NA hsa-miR-3065-5p CCND2 2.14185373842821 0.0609400502269891 -2.81051675901102 0.00139983736368543 mirMAP -0.198616424838265 0.000257635954140166 NA NA NA hsa-miR-30d-3p CCND2 -0.0740421896025512 0.857423650167556 -2.81051675901102 0.00139983736368543 mirMAP -0.548341190913964 7.47249707616609e-06 NA NA NA hsa-miR-324-3p CCND2 1.51345381556672 0.0038447546677657 -2.81051675901102 0.00139983736368543 miRNAWalker2_validate -0.43719832262749 4.09891269304966e-06 NA NA NA hsa-miR-33a-3p CCND2 2.06269680799532 0.00156436055383943 -2.81051675901102 0.00139983736368543 MirTarget -0.270924955791957 0.000410846654094401 NA NA NA hsa-miR-378a-3p CCND2 1.46612141870273 0.0466660641196872 -2.81051675901102 0.00139983736368543 miRNAWalker2_validate -0.186901666998984 0.00600686499792038 NA NA NA hsa-miR-429 CCND2 6.39965293994036 1.96920201593608e-18 -2.81051675901102 0.00139983736368543 miRNATAP -0.457780562605429 2.24817157133262e-13 NA NA NA hsa-miR-497-5p CCND2 -1.44150596209372 0.0225146607606395 -2.81051675901102 0.00139983736368543 MirTarget;miRNATAP -0.272420525595686 0.000579324260115001 NA NA NA hsa-miR-550a-5p CCND2 1.21781238856895 0.0613791144699551 -2.81051675901102 0.00139983736368543 MirTarget -0.224646283844048 0.00363403467531415 NA NA NA hsa-miR-660-5p CCND2 -0.0668683798854808 0.885250178390404 -2.81051675901102 0.00139983736368543 mirMAP -0.290960137515711 0.00793054638018279 NA NA NA hsa-miR-9-3p CCND2 1.69328215716742 0.125170982657059 -2.81051675901102 0.00139983736368543 MirTarget;mirMAP;miRNATAP -0.143162485603445 0.00185116011719342 NA NA NA hsa-miR-93-5p CCND2 2.65964181833033 2.58315947526774e-08 -2.81051675901102 0.00139983736368543 miRNATAP -0.48060449639845 2.62594110203289e-06 NA NA NA hsa-miR-96-5p CCND2 5.62521466029286 1.54938806718028e-10 -2.81051675901102 0.00139983736368543 TargetScan;miRNATAP -0.24395409924335 0.000303822796805944 NA NA NA hsa-miR-27b-3p CCND3 -0.0929089601968123 0.85847352206581 -0.53759657598867 0.124370433214632 miRNAWalker2_validate -0.141758210053908 0.000190546260809965 NA NA NA hsa-miR-429 CCND3 6.39965293994036 1.96920201593608e-18 -0.53759657598867 0.124370433214632 miRNATAP -0.112877673525875 7.62633278325715e-06 NA NA NA hsa-miR-96-5p CCND3 5.62521466029286 1.54938806718028e-10 -0.53759657598867 0.124370433214632 TargetScan -0.116905111437921 9.66017245986979e-06 NA NA NA hsa-miR-125b-5p CCNE1 -2.01187572101832 0.00516480893645494 3.90668327437123 7.68546937179809e-18 miRNAWalker2_validate -0.127872185036842 0.000654725383789322 NA NA NA hsa-miR-195-5p CCNE1 -1.59182537400701 0.0169128463756769 3.90668327437123 7.68546937179809e-18 miRNAWalker2_validate;MirTarget;miRNATAP -0.11514367249823 0.00470453662143774 24402230 Furthermore through qPCR and western blot assays we showed that overexpression of miR-195-5p reduced CCNE1 mRNA and protein levels respectively breast cancer hsa-miR-26a-5p CCNE1 -0.352368463397074 0.362040749917446 3.90668327437123 7.68546937179809e-18 miRNAWalker2_validate;miRTarBase;miRNATAP -0.184731728950396 0.00988349874140469 22094936 Cell cycle regulation and CCNE1 and CDC2 were the only significant overlapping pathway and genes differentially expressed between tumors with high and low levels of miR-26a and EZH2 respectively; Low mRNA levels of EZH2 CCNE1 and CDC2 and high levels of miR-26a are associated with favorable outcome on tamoxifen breast cancer hsa-miR-497-5p CCNE1 -1.44150596209372 0.0225146607606395 3.90668327437123 7.68546937179809e-18 MirTarget;miRNATAP -0.126936185159413 0.00315358484504579 24909281;24112607;25909221 miR 497 suppresses proliferation of human cervical carcinoma HeLa cells by targeting cyclin E1; Furthermore the target effect of miR-497 on the CCNE1 was identified by dual-luciferase reporter assay system qRT-PCR and Western blotting; Over-expressed miR-497 in HeLa cells could suppress cell proliferation by targeting CCNE1;Western blot assays confirmed that overexpression of miR-497 reduced cyclin E1 protein levels; Inhibited cellular growth suppressed cellular migration and invasion and G1 cell cycle arrest were observed upon overexpression of miR-497 in cells possibly by targeting cyclin E1;The effect of simultaneous overexpression of miR-497 and miR-34a on the inhibition of cell proliferation colony formation and tumor growth and the downregulation of cyclin E1 was stronger than the effect of each miRNA alone; The synergistic actions of miR-497 and miR-34a partly correlated with cyclin E1 levels; These results indicate cyclin E1 is downregulated by both miR-497 and miR-34a which synergistically retard the growth of human lung cancer cells ;; cervical and endocervical cancer;breast cancer;lung cancer hsa-miR-28-3p CCNE2 -0.992446114847535 0.0188188359018203 4.77667612901641 6.489939090147e-18 PITA;miRNATAP -0.212700603723915 0.00739021768839842 NA NA NA hsa-miR-30a-5p CCNE2 -0.768430903969183 0.320487552854215 4.77667612901641 6.489939090147e-18 miRNATAP -0.229409802316148 5.49447336865621e-08 NA NA NA hsa-let-7a-3p CDC14A 0.82512001802525 0.0468122405194487 -0.949281484236199 0.155298903433688 mirMAP -0.312698608561319 0.000670110304627258 NA NA NA hsa-let-7f-1-3p CDC14A 1.61507869803314 0.00069342464777815 -0.949281484236199 0.155298903433688 mirMAP -0.416175957984357 1.20134597937096e-07 NA NA NA hsa-miR-142-3p CDC14A 4.35304505457969 3.10014573651358e-10 -0.949281484236199 0.155298903433688 miRanda -0.190682680924883 0.000313612321118974 NA NA NA hsa-miR-146b-5p CDC14A 1.87569569182453 0.000737241069698886 -0.949281484236199 0.155298903433688 miRanda -0.191430792259971 0.00480063602013273 NA NA NA hsa-miR-330-3p CDC14A 2.49094236945806 0.000129367003214715 -0.949281484236199 0.155298903433688 mirMAP -0.216939691053529 0.000163285189566909 NA NA NA hsa-miR-342-3p CDC14A 1.31107714473009 0.0207211910724662 -0.949281484236199 0.155298903433688 miRanda -0.273633058361352 3.73374061494405e-05 NA NA NA hsa-miR-590-3p CDC14A 2.35429565068338 2.79601879608564e-06 -0.949281484236199 0.155298903433688 PITA;miRanda;mirMAP;miRNATAP -0.242478898927965 0.00112412625759176 NA NA NA hsa-miR-944 CDC14A 7.20925181386398 0.000823207457340648 -0.949281484236199 0.155298903433688 mirMAP -0.151023698879735 4.56311899655109e-13 NA NA NA hsa-miR-193a-5p CDC14B 0.511907930518603 0.239278601221583 -0.578311757244786 0.390821790191238 miRNATAP -0.313318007078802 0.000391547968878659 NA NA NA hsa-miR-27b-3p CDC14B -0.0929089601968123 0.85847352206581 -0.578311757244786 0.390821790191238 miRNATAP -0.218071264356021 0.00308788799847272 NA NA NA hsa-miR-944 CDC14B 7.20925181386398 0.000823207457340648 -0.578311757244786 0.390821790191238 PITA;mirMAP;miRNATAP -0.107756796796085 5.33774159398882e-07 NA NA NA hsa-let-7c-5p CDC25A -2.03831836681378 0.0228401148731997 4.20882972437541 4.35199432282222e-21 MirTarget -0.123137458192374 3.7232087913699e-05 25909324 MicroRNA let 7c Inhibits Cell Proliferation and Induces Cell Cycle Arrest by Targeting CDC25A in Human Hepatocellular Carcinoma; The aim of the present study was to determine whether the cell cycle regulator CDC25A is involved in the antitumor effect of let-7c in HCC; The luciferase reporter assay showed that CDC25A was a direct target of let-7c and that let-7c inhibited the expression of CDC25A protein by directly targeting its 3' UTR; In conclusion this study indicates that let-7c suppresses HCC progression possibly by directly targeting the cell cycle regulator CDC25A and indirectly affecting its downstream target molecules progression liver cancer hsa-miR-195-5p CDC25A -1.59182537400701 0.0169128463756769 4.20882972437541 4.35199432282222e-21 MirTarget;miRNATAP -0.132229108195972 0.00107665402042969 NA NA NA hsa-miR-199a-5p CDC6 -1.24888110793613 0.0747755616523728 5.86822286906338 2.3350388439057e-49 miRanda -0.148325314409162 7.84128517029418e-05 NA NA NA hsa-miR-199b-5p CDC6 -0.53728867775768 0.476885702455766 5.86822286906338 2.3350388439057e-49 miRanda -0.118620775676635 0.0007038970245053 NA NA NA hsa-miR-140-5p CDK2 -0.634610285725923 0.126670572966239 1.42489416332317 1.62801715893662e-05 miRanda -0.121906717948301 0.00814170704237931 NA NA NA hsa-let-7a-5p CDK6 0.148081801547773 0.645305441523746 0.50406574702617 0.551236779554206 miRNAWalker2_validate;miRTarBase;TargetScan -0.645439384156813 2.08585558666525e-05 NA NA NA hsa-let-7b-5p CDK6 -0.189422992330471 0.651878220048983 0.50406574702617 0.551236779554206 miRNAWalker2_validate;miRTarBase -0.465531746051444 5.04007910683628e-05 NA NA NA hsa-miR-101-3p CDK6 -1.12421603598195 0.0200907284788457 0.50406574702617 0.551236779554206 mirMAP -0.421606618743612 1.93327021487929e-05 NA NA NA hsa-miR-106a-5p CDK6 3.98693608217557 9.37722470816656e-07 0.50406574702617 0.551236779554206 mirMAP -0.3914421268643 2.58029820594243e-12 NA NA NA hsa-miR-141-3p CDK6 7.30474126597325 1.45115996357606e-24 0.50406574702617 0.551236779554206 TargetScan;miRNATAP -0.20492670051454 0.00089997435535192 NA NA NA hsa-miR-148b-3p CDK6 1.75622244535669 8.84414356040579e-08 0.50406574702617 0.551236779554206 mirMAP -0.473118253356064 0.00117507520744895 NA NA NA hsa-miR-200a-3p CDK6 6.336081120041 4.024313571871e-16 0.50406574702617 0.551236779554206 miRNATAP -0.351978863285198 6.61784093516688e-10 24009066 microRNA 200a is an independent prognostic factor of hepatocellular carcinoma and induces cell cycle arrest by targeting CDK6 liver cancer hsa-miR-200b-3p CDK6 5.56167217794639 6.43540045061709e-16 0.50406574702617 0.551236779554206 mirMAP -0.393674008810918 1.1478210539551e-09 NA NA NA hsa-miR-20b-5p CDK6 4.5662923200279 4.75238200639144e-05 0.50406574702617 0.551236779554206 mirMAP -0.284732309778902 2.48291204663733e-12 26166554 The transfection of miR-20b into EJ cells induced G1 phase cell cycle arrest via the decreased expression of cyclin D1 CDK2 and CDK6 without affecting another G1 phase cell cycle regulator cyclin E bladder cancer hsa-miR-30a-5p CDK6 -0.768430903969183 0.320487552854215 0.50406574702617 0.551236779554206 mirMAP -0.173159552692541 0.0051696250748206 NA NA NA hsa-miR-30d-5p CDK6 0.302504510257496 0.380193536606962 0.50406574702617 0.551236779554206 mirMAP -0.498058868266233 0.00043364409008621 NA NA NA hsa-miR-30e-5p CDK6 0.780047227271616 0.0346714425913016 0.50406574702617 0.551236779554206 mirMAP -0.536440221801356 4.09131973520604e-05 NA NA NA hsa-miR-34a-5p CDK6 0.830377770217786 0.0477544831885907 0.50406574702617 0.551236779554206 miRNAWalker2_validate;miRTarBase;miRNATAP -0.36060880640799 0.00174841793217821 21702042;26104764 Molecular analyses identified Cdk6 and sirtuin SIRT-1 as being targeted by miR-34a in MI-TCC cells however inhibition of Cdk6 and SIRT-1 was not as effective as pre-miR-34a in mediating chemosensitization;The expression of microRNA 34a is inversely correlated with c MET and CDK6 and has a prognostic significance in lung adenocarcinoma patients; We found significant inverse correlations between miR-34a and c-MET R = -0.316 P = 0.028 and CDK6 expression R = -0.4582 P = 0.004 ; bladder cancer;lung cancer hsa-miR-362-5p CDK6 -1.22309034685697 0.0452665543907975 0.50406574702617 0.551236779554206 mirMAP -0.285526744495543 0.000257106653086971 NA NA NA hsa-miR-429 CDK6 6.39965293994036 1.96920201593608e-18 0.50406574702617 0.551236779554206 mirMAP;miRNATAP -0.252321841763607 3.87842873215362e-05 NA NA NA hsa-miR-497-5p CDK6 -1.44150596209372 0.0225146607606395 0.50406574702617 0.551236779554206 miRNATAP -0.311206501941814 3.48572516094014e-05 NA NA NA hsa-miR-502-3p CDK6 -0.102232623565007 0.80889202592629 0.50406574702617 0.551236779554206 PITA;miRNATAP -0.416650063741403 0.000268656241814273 NA NA NA hsa-miR-592 CDK6 2.80403350008555 0.0293520213681333 0.50406574702617 0.551236779554206 mirMAP -0.23124216841781 2.55195577436831e-07 NA NA NA hsa-miR-660-5p CDK6 -0.0668683798854808 0.885250178390404 0.50406574702617 0.551236779554206 mirMAP -0.371049523443998 0.000362174896273971 NA NA NA hsa-miR-542-3p CDK7 -0.376147863244659 0.438002751207043 0.579447991873467 0.074429649835343 miRanda -0.119229936549122 0.00173436455351827 NA NA NA hsa-let-7e-5p CDKN1A -0.111012524740586 0.814744515884005 0.575565460455045 0.357582494899873 MirTarget -0.274146718755294 0.000263797572767074 NA NA NA hsa-let-7g-5p CDKN1A 0.857251702023746 0.00647597344297273 0.575565460455045 0.357582494899873 MirTarget -0.31692390865002 0.00585926212615004 NA NA NA hsa-miR-125a-5p CDKN1A -1.32352790615388 0.00714301627309467 0.575565460455045 0.357582494899873 miRNAWalker2_validate;miRTarBase -0.352961178589696 7.16598889800001e-07 NA NA NA hsa-miR-28-5p CDKN1A -0.815636722979196 0.0221199948901761 0.575565460455045 0.357582494899873 miRNAWalker2_validate;miRTarBase;MirTarget;miRanda;miRNATAP -0.54618253223586 3.67357997876153e-08 NA NA NA hsa-miR-30b-3p CDKN1A 0.169674321578618 0.766080356926625 0.575565460455045 0.357582494899873 MirTarget -0.164844746301017 0.00864162465933599 NA NA NA hsa-miR-335-5p CDKN1A 0.167216045757305 0.803897055331049 0.575565460455045 0.357582494899873 miRNAWalker2_validate -0.250609725261631 1.48353826571499e-06 NA NA NA hsa-miR-345-5p CDKN1A 2.77314563304336 4.34343702412489e-05 0.575565460455045 0.357582494899873 miRNAWalker2_validate;miRTarBase;MirTarget -0.226896440422906 9.12582037640469e-06 NA NA NA hsa-miR-423-3p CDKN1A 1.7128674316395 1.7145324528301e-05 0.575565460455045 0.357582494899873 miRNAWalker2_validate;miRTarBase -0.268279490593696 0.00252767646001539 NA NA NA hsa-miR-505-5p CDKN1A -0.548246528900629 0.331409094367131 0.575565460455045 0.357582494899873 miRNAWalker2_validate;MirTarget -0.176195799792848 0.00518737322213012 NA NA NA hsa-miR-616-5p CDKN1A 2.48416313933027 0.00318247475868827 0.575565460455045 0.357582494899873 mirMAP -0.143849376151027 0.00610419478950803 NA NA NA hsa-miR-96-5p CDKN1A 5.62521466029286 1.54938806718028e-10 0.575565460455045 0.357582494899873 miRNAWalker2_validate;miRTarBase -0.170734648939045 0.000337982107370655 26582573 Upregulation of microRNA 96 and its oncogenic functions by targeting CDKN1A in bladder cancer; Bioinformatics prediction combined with luciferase reporter assay were used to verify whether the cyclin-dependent kinase inhibitor CDKN1A was a potential target gene of miR-96; According to the data of miRTarBase CDKN1A might be a candidate target gene of miR-96; In addition luciferase reporter and Western blot assays respectively demonstrated that miR-96 could bind to the putative seed region in CDKN1A mRNA 3'UTR and significantly reduce the expression level of CDKN1A protein; Moreover we found that the inhibition of miR-96 expression remarkably decreased cell proliferation and promoted cell apoptosis of BC cell lines which was consistent with the findings observed following the introduction of CDKN1A cDNA without 3'UTR restored miR-96; Upregulation of miR-96 may contribute to aggressive malignancy partly through suppressing CDKN1A protein expression in BC cells bladder cancer hsa-miR-221-3p CDKN1B 0.94082283577318 0.174749164179978 -0.759845869565624 0.028743899515939 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.200797560518329 2.03736102209363e-13 23637992;19953484;23939688;19126397;20146005;23967190;17569667;22992757;17721077;20461750 miR-221 knockdown not only blocked cell cycle progression induced cell apoptosis and inhibited cell proliferation in-vitro but it also inhibited in-vivo tumor growth by targeting p27kip1;Based on bioinformatic analysis we found that the seed sequences of miR-221 and miR-222 coincide with each other and p27kip1 is a target for miRNA-221/222;A Slug/miR-221 network has been suggested linking miR-221 activity with the downregulation of a Slug repressor leading to Slug/miR-221 upregulation and p27Kip1 downregulation; Interference with this process can be achieved using antisense miRNA antagomiR molecules targeting miR-221 inducing the downregulation of Slug and the upregulation of p27Kip1;Moreover a series of functional assays demonstrated that mir-221 could directly inhibit cKit p27Kip1 and possibly other pivotal proteins in melanoma;Matched HCC and adjacent non-cancerous samples were assayed for the expression of miR-221 and three G1/S transition inhibitors: p27Kip1 p21WAF1/Cip1and TGF-β1 by in situ hybridization and immunohistochemistry respectively; Real time qRT-PCR was used to investigate miR-221 and p27Kip1 transcripts in different clinical stages; In result miR-221 and TGF-β1 are frequently up-regulated in HCC while p27Kip1 and p21WAF1/Cip1 proteins are frequently down-regulated; In conclusion miR-221 is important in tumorigenesis of HCC possibly by specifically down-regulating p27Kip1 a cell-cycle inhibitor;Additionally the PDGF-dependent increase in cell proliferation appears to be mediated by inhibition of a specific target of miR-221 and down-regulation of p27Kip1;miR 221 and miR 222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1; In all cell lines tested we show an inverse relationship between the expression of miR-221 and miR-222 and the cell cycle inhibitor p27Kip1; Consistently miR-221 and miR-222 knock-down through antisense LNA oligonucleotides increases p27Kip1 in PC3 cells and strongly reduces their clonogenicity in vitro;Peptide nucleic acids targeting miR 221 modulate p27Kip1 expression in breast cancer MDA MB 231 cells; Targeting miR-221 by PNA resulted in i lowering of the hybridization levels of miR-221 measured by RT-qPCR ii upregulation of p27Kip1 gene expression measured by RT-qPCR and western blot analysis;Antagonism of either microRNA 221 or 222 in glioblastoma cells also caused an increase in p27Kip1 levels and enhanced expression of the luciferase reporter gene fused to the p27Kip1 3'UTR;MiR 221 and MiR 222 alterations in sporadic ovarian carcinoma: Relationship to CDKN1B CDKNIC and overall survival; miR-221 and miR-222 negatively regulate expression of CDKN1B p27 and CDKN1C p57 two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas; In contrast CDKN1B expression was not associated with miR-221 or miR-222 expression progression;;;;staging;tumorigenesis;;;;;poor survival breast cancer;glioblastoma;breast cancer;melanoma;liver cancer;pancreatic cancer;prostate cancer;breast cancer;glioblastoma;ovarian cancer hsa-miR-222-3p CDKN1B 1.54730827524553 0.0223014220569407 -0.759845869565624 0.028743899515939 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.203256369475779 3.47768078668867e-13 24895988;19953484;26912358;24137356;17569667;27282281;20461750 MiR-222 plays an important role in the tumorigenesis of CC possibly by specifically down-regulating p27Kip1 and PTEN;Based on bioinformatic analysis we found that the seed sequences of miR-221 and miR-222 coincide with each other and p27kip1 is a target for miRNA-221/222;Besides microvesicle marker characterization we evidenced that miR-222 exosomal expression mostly reflected its abundance in the cells of origin correctly paralleled by repression of its target genes such as p27Kip1 and induction of the PI3K/AKT pathway thus confirming its functional implication in cancer;miR 222 is upregulated in epithelial ovarian cancer and promotes cell proliferation by downregulating P27kip1; miR-222 upregulation induced an enhancement of ovarian cancer cell proliferation potential possibly by downregulating its target P27Kip1; A bioinformatic analysis showed that the 3'-UTR of the P27Kip1 mRNA contained a highly-conserved putative miR-222 binding site; Luciferase reporter assays demonstrated that P27Kip1 was a direct target of miR-222; Consistently there was an inverse correlation between the P27Kip1 and miR-222 expression levels in the ovarian cancer cell lines and tissues;miR 221 and miR 222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1; In all cell lines tested we show an inverse relationship between the expression of miR-221 and miR-222 and the cell cycle inhibitor p27Kip1; Consistently miR-221 and miR-222 knock-down through antisense LNA oligonucleotides increases p27Kip1 in PC3 cells and strongly reduces their clonogenicity in vitro;miR 222 confers the resistance of breast cancer cells to Adriamycin through suppression of p27kip1 expression; Immunofluorescence showed that miR-222 altered the subcellular location of p27kip1 in nucleus; The results showed that downregulation of miR-222 in MCF-7/Adr increased sensitivity to Adr and Adr-induced apoptosis and arrested the cells in G1 phase accompanied by more expressions of p27kip1 especially in nucleus; Taken together the results found that miR-222 induced Adr-resistance at least in part via suppressing p27kip1 expression and altering its subcellular localization and miR-222 inhibitors could reverse Adr-resistance of breast cancer cells;MiR 221 and MiR 222 alterations in sporadic ovarian carcinoma: Relationship to CDKN1B CDKNIC and overall survival; miR-221 and miR-222 negatively regulate expression of CDKN1B p27 and CDKN1C p57 two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas; In contrast CDKN1B expression was not associated with miR-221 or miR-222 expression tumorigenesis;;;;;drug resistance;poor survival cervical and endocervical cancer;glioblastoma;melanoma;ovarian cancer;prostate cancer;breast cancer;ovarian cancer hsa-miR-24-3p CDKN1B 1.55853749533999 0.000524726461381821 -0.759845869565624 0.028743899515939 miRNAWalker2_validate;miRNATAP -0.227681406286786 1.26095324894704e-07 26847530;26044523 The biological significance of miR-24 expression in prostate cancer cells was assessed by a series of in vitro bioassays and the effect on proposed targets p27 CDKN1B and p16 CDK2NA was investigated;With the bioinformatic method we further identified that p27Kip1 is a direct target of miR-24-3p and its protein level was negatively regulated by miR-24-3p ; prostate cancer;breast cancer hsa-miR-421 CDKN1B 1.97624148591545 0.000915838012451138 -0.759845869565624 0.028743899515939 miRanda -0.112669451915086 0.000596982834425083 NA NA NA hsa-miR-455-5p CDKN1B -0.317715589860275 0.616296031007863 -0.759845869565624 0.028743899515939 miRanda;miRNATAP -0.114301116622919 0.000221318473800826 NA NA NA hsa-miR-221-3p CDKN1C 0.94082283577318 0.174749164179978 -2.66944462471306 0.00187643913237671 miRNAWalker2_validate;miRTarBase;miRNATAP -0.240299855291002 0.000651829345064921 20461750 miR-221 and miR-222 negatively regulate expression of CDKN1B p27 and CDKN1C p57 two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas; Higher miR-222 and miR-221 expression were significantly associated with decreased CDKN1C expression P = 0.009 and 0.01 ovarian cancer hsa-miR-222-3p CDKN1C 1.54730827524553 0.0223014220569407 -2.66944462471306 0.00187643913237671 miRNAWalker2_validate;miRTarBase;miRNATAP -0.237364857177038 0.000984690850949802 20461750 miR-221 and miR-222 negatively regulate expression of CDKN1B p27 and CDKN1C p57 two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas; Higher miR-222 and miR-221 expression were significantly associated with decreased CDKN1C expression P = 0.009 and 0.01 ovarian cancer hsa-miR-10b-5p CDKN2A -3.08172917642729 4.22675074435126e-09 7.38430007921313 1.9263072669935e-15 miRNAWalker2_validate;miRTarBase -0.3561025709733 0.00054319451875627 NA NA NA hsa-miR-125a-5p CDKN2A -1.32352790615388 0.00714301627309467 7.38430007921313 1.9263072669935e-15 miRanda -0.392381455588874 0.000480466623544498 NA NA NA hsa-miR-107 CDKN2B 1.49443409571439 0.000130594521065411 3.0483618600868 0.000209973570530815 PITA -0.451661629246362 0.000176451976452473 NA NA NA hsa-miR-125a-3p CDKN2B -0.0748960586927341 0.920735897434087 3.0483618600868 0.000209973570530815 miRanda -0.281235486977565 5.87183094847568e-06 NA NA NA hsa-miR-125a-5p CDKN2B -1.32352790615388 0.00714301627309467 3.0483618600868 0.000209973570530815 miRanda -0.607767279625756 7.34559713840635e-11 NA NA NA hsa-miR-126-5p CDKN2B -0.420466581381807 0.329972801718418 3.0483618600868 0.000209973570530815 mirMAP -0.384730895689604 0.000468547465389506 NA NA NA hsa-miR-217 CDKN2B -0.378397407994341 0.717408682071252 3.0483618600868 0.000209973570530815 miRanda -0.146340892670124 0.0011879794504395 NA NA NA hsa-miR-28-5p CDKN2B -0.815636722979196 0.0221199948901761 3.0483618600868 0.000209973570530815 miRanda -0.813818647185525 5.20786465614388e-10 NA NA NA hsa-miR-335-3p CDKN2B 1.19503568251824 0.0938852560631551 3.0483618600868 0.000209973570530815 mirMAP -0.230132652662327 0.000461918630662828 NA NA NA hsa-miR-374b-5p CDKN2B -0.114749866169918 0.764888930049438 3.0483618600868 0.000209973570530815 miRNAWalker2_validate -0.427660032295754 0.000588414390873068 NA NA NA hsa-miR-375 CDKN2B 3.3784490463318 0.0449946294355695 3.0483618600868 0.000209973570530815 miRNAWalker2_validate;miRNATAP -0.135134550270944 7.98570366612466e-07 NA NA NA hsa-miR-450b-5p CDKN2B 0.445103105471153 0.416021465008949 3.0483618600868 0.000209973570530815 mirMAP -0.269827235831244 0.00178266967612344 NA NA NA hsa-miR-495-3p CDKN2B -1.28495103468384 0.0979462503954353 3.0483618600868 0.000209973570530815 MirTarget -0.177011624965662 0.00348969353672305 NA NA NA hsa-miR-501-3p CDKN2B 1.72239979688923 0.0075900263732748 3.0483618600868 0.000209973570530815 PITA -0.382280585734888 9.20643371704555e-08 NA NA NA hsa-miR-501-5p CDKN2B 1.0411896821345 0.0777206709183552 3.0483618600868 0.000209973570530815 mirMAP -0.353195575048531 8.09502902784753e-06 NA NA NA hsa-miR-502-3p CDKN2B -0.102232623565007 0.80889202592629 3.0483618600868 0.000209973570530815 PITA -0.501828823781054 7.10109662589701e-06 NA NA NA hsa-miR-582-5p CDKN2B 0.685177900016753 0.447761540297692 3.0483618600868 0.000209973570530815 miRNATAP -0.142565867298399 0.00622437078082883 NA NA NA hsa-miR-671-5p CDKN2B 1.48527046124636 0.00686722328347111 3.0483618600868 0.000209973570530815 PITA -0.353451371274366 3.22699968328056e-05 NA NA NA hsa-miR-7-1-3p CDKN2B 1.43074343339835 0.00471215970502094 3.0483618600868 0.000209973570530815 MirTarget -0.357518494533497 0.000112620950429957 NA NA NA hsa-miR-129-5p CDKN2C -2.66843722411409 0.00695783358331245 1.32249242705023 0.0812569788200476 miRanda -0.129797219304394 0.0031085580069578 NA NA NA hsa-miR-192-5p CDKN2D 1.77716187978541 0.113485496183047 0.735567389284941 0.166670413921761 miRNAWalker2_validate -0.108607725784769 4.20480410067568e-05 NA NA NA hsa-miR-21-3p CREBBP 3.50297439576639 6.39946844099206e-10 -0.3958302023172 0.180670093990074 MirTarget -0.1378273582574 1.08112070034993e-06 NA NA NA hsa-miR-590-3p CREBBP 2.35429565068338 2.79601879608564e-06 -0.3958302023172 0.180670093990074 PITA;miRanda;mirMAP;miRNATAP -0.100352894791816 0.00219317602458258 NA NA NA hsa-let-7e-5p E2F2 -0.111012524740586 0.814744515884005 6.82063864344197 1.35655780479993e-27 MirTarget -0.350484057548809 2.024430693681e-05 NA NA NA hsa-miR-125a-5p E2F2 -1.32352790615388 0.00714301627309467 6.82063864344197 1.35655780479993e-27 MirTarget -0.352332974452031 7.20567181776122e-06 NA NA NA hsa-miR-30c-2-3p E2F2 -0.916427677918778 0.300195789569016 6.82063864344197 1.35655780479993e-27 MirTarget -0.207615821851496 1.7140994891733e-06 NA NA NA hsa-let-7b-5p E2F3 -0.189422992330471 0.651878220048983 1.53958974317983 3.49938865756243e-05 miRNAWalker2_validate -0.151854140416444 0.00308404945862645 NA NA NA hsa-miR-101-3p E2F3 -1.12421603598195 0.0200907284788457 1.53958974317983 3.49938865756243e-05 miRNAWalker2_validate -0.131683830508214 0.0028605957927584 NA NA NA hsa-miR-125b-5p E2F3 -2.01187572101832 0.00516480893645494 1.53958974317983 3.49938865756243e-05 miRNAWalker2_validate;miRTarBase;miRNATAP -0.118655757183925 4.89790966907073e-05 22523546;20549700 Moreover we demonstrated that the E2F3 was a direct target of miR-125b in breast cancer cells;E2F3 which was critical for G1/S transition and was overexpressed in most of poor-differentiated bladder cancers was identified as a target of miR-125b by luciferase assay; Introduction of miR-125b could reduce the expression of E2F3 protein but not the E2F3 mRNA ; breast cancer;bladder cancer hsa-miR-145-5p E2F3 -3.55505374822025 5.45525288912869e-07 1.53958974317983 3.49938865756243e-05 miRNATAP -0.1086482465251 0.00020726109409641 25762621 miR 145 mediates the antiproliferative and gene regulatory effects of vitamin D3 by directly targeting E2F3 in gastric cancer cells; Furthermore miR-145 expression was lower in tumors compared with matched normal samples and correlated with increased the E2F3 transcription factor protein staining gastric cancer hsa-miR-221-3p E2F3 0.94082283577318 0.174749164179978 1.53958974317983 3.49938865756243e-05 miRNAWalker2_validate -0.100962238252787 0.000978172817836866 NA NA NA hsa-miR-497-5p E2F3 -1.44150596209372 0.0225146607606395 1.53958974317983 3.49938865756243e-05 miRNATAP -0.117531800831356 0.000454176319719473 NA NA NA hsa-let-7f-5p E2F5 0.971961126099146 0.0240319857511033 -0.639266662126547 0.416174414596425 MirTarget;miRNATAP -0.353852840088557 0.000664150120910199 NA NA NA hsa-let-7i-5p E2F5 0.0473185312396307 0.869714142234765 -0.639266662126547 0.416174414596425 MirTarget;miRNATAP -0.494751518747998 0.00193678048367326 NA NA NA hsa-miR-1-3p E2F5 -3.85397883903804 6.93274972711165e-06 -0.639266662126547 0.416174414596425 MirTarget -0.151433993301856 0.00306193575274417 NA NA NA hsa-miR-142-3p E2F5 4.35304505457969 3.10014573651358e-10 -0.639266662126547 0.416174414596425 miRanda -0.168926633694876 0.00689492861438165 NA NA NA hsa-miR-205-5p E2F5 8.08298115900323 3.83045179398654e-07 -0.639266662126547 0.416174414596425 miRNAWalker2_validate;miRTarBase;miRNATAP -0.184708069923657 2.74621532953329e-12 21454583 The expression levels of E2F1 and E2F5 were correlated inversely with that of miR-205 in melanoma cell lines; miR-205 significantly suppressed the luciferase activity of reporter plasmids containing the 3'-UTR sequences complementary to either E2F1 or E2F5; Overexpression of miR-205 in melanoma cells reduced E2F1 and E2F5 protein levels melanoma hsa-miR-34c-5p E2F5 2.64675661251039 0.0157394735757952 -0.639266662126547 0.416174414596425 MirTarget;PITA;miRanda;miRNATAP -0.157867299377243 8.51362892001314e-05 NA NA NA hsa-miR-148a-3p EP300 1.1031350648218 0.052038169812979 0.224331914964019 0.578934208058052 miRNATAP -0.104185690998739 0.00975228544208279 NA NA NA hsa-miR-30c-5p EP300 0.38723991118075 0.348605235643473 0.224331914964019 0.578934208058052 miRNAWalker2_validate -0.18542784496307 0.000897194160521004 NA NA NA hsa-miR-339-5p EP300 1.23326828594484 0.0307501214818698 0.224331914964019 0.578934208058052 miRanda -0.199156483102611 4.47682764951844e-07 NA NA NA hsa-miR-342-3p EP300 1.31107714473009 0.0207211910724662 0.224331914964019 0.578934208058052 MirTarget;PITA;miRanda;miRNATAP -0.115722711407846 0.00406603413994019 NA NA NA hsa-miR-374b-5p EP300 -0.114749866169918 0.764888930049438 0.224331914964019 0.578934208058052 mirMAP;miRNATAP -0.159199926258203 0.00855691297646884 NA NA NA hsa-miR-590-3p EP300 2.35429565068338 2.79601879608564e-06 0.224331914964019 0.578934208058052 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.136964991854083 0.00229030845745203 NA NA NA hsa-miR-125a-5p ESPL1 -1.32352790615388 0.00714301627309467 5.93763381842608 3.77049538511446e-40 miRanda -0.2268392293627 0.000112215913967803 NA NA NA hsa-miR-125a-5p FZR1 -1.32352790615388 0.00714301627309467 0.285825643438138 0.386537934038954 mirMAP -0.149481178941361 7.21407646797478e-05 NA NA NA hsa-miR-129-5p GADD45A -2.66843722411409 0.00695783358331245 -0.566112082294352 0.356860494529648 miRanda -0.100844116127556 0.00449173907374446 NA NA NA hsa-miR-130b-3p GADD45A 3.9204771543282 1.2714917955808e-11 -0.566112082294352 0.356860494529648 MirTarget;miRNATAP -0.171179592036229 0.0032386084520536 NA NA NA hsa-miR-146b-5p GADD45A 1.87569569182453 0.000737241069698886 -0.566112082294352 0.356860494529648 miRanda -0.18967214107464 0.00232775278051048 NA NA NA hsa-miR-148b-3p GADD45A 1.75622244535669 8.84414356040579e-08 -0.566112082294352 0.356860494529648 MirTarget -0.525743475009119 5.01282872316168e-07 NA NA NA hsa-miR-301a-3p GADD45A 1.99338115332667 0.000813358604963724 -0.566112082294352 0.356860494529648 MirTarget;miRNATAP -0.190939096191683 0.000994881284680524 NA NA NA hsa-miR-362-5p GADD45A -1.22309034685697 0.0452665543907975 -0.566112082294352 0.356860494529648 MirTarget;PITA;miRNATAP -0.174083394504546 0.00221778809043954 NA NA NA hsa-miR-375 GADD45A 3.3784490463318 0.0449946294355695 -0.566112082294352 0.356860494529648 miRanda -0.102232241980599 4.20822114251968e-07 NA NA NA hsa-miR-454-3p GADD45A 1.40269869979902 0.00366085847011367 -0.566112082294352 0.356860494529648 MirTarget;miRNATAP -0.309147097462117 1.56973939454024e-05 NA NA NA hsa-miR-500a-5p GADD45A 0.0170829425378565 0.973960207660626 -0.566112082294352 0.356860494529648 MirTarget;miRNATAP -0.191557624174549 0.00426069074325481 NA NA NA hsa-miR-500b-5p GADD45A 0.0167434146432646 0.974498641907253 -0.566112082294352 0.356860494529648 MirTarget -0.191191795665263 0.0043023159901196 NA NA NA hsa-miR-324-3p GADD45B 1.51345381556672 0.0038447546677657 -1.882739402569 0.00168698437811886 MirTarget;miRNATAP -0.17112830558095 0.00882982096915685 NA NA NA hsa-miR-1976 GADD45G 3.27217274919653 3.16337235854532e-12 -3.78199148373951 7.47113859248823e-06 MirTarget -0.339364756241224 0.000704281453896161 NA NA NA hsa-miR-181c-5p GSK3B -0.302833440762172 0.537532549455539 0.984264794042029 0.00614784819440891 mirMAP -0.115369483842179 0.00582165998524454 NA NA NA hsa-miR-30a-3p GSK3B -1.22212086897848 0.167565797592104 0.984264794042029 0.00614784819440891 miRNATAP -0.11517576765646 3.57050461951731e-07 NA NA NA hsa-miR-30d-3p GSK3B -0.0740421896025512 0.857423650167556 0.984264794042029 0.00614784819440891 miRNATAP -0.217356687168476 1.21966436788369e-05 NA NA NA hsa-miR-320c GSK3B -0.10618808730545 0.854002814666472 0.984264794042029 0.00614784819440891 miRanda;mirMAP -0.100605875350465 0.00537879672016752 NA NA NA hsa-miR-362-5p GSK3B -1.22309034685697 0.0452665543907975 0.984264794042029 0.00614784819440891 miRNATAP -0.116235509089146 0.000473661337943669 NA NA NA hsa-miR-146b-5p HDAC2 1.87569569182453 0.000737241069698886 0.396222421819743 0.222645527527983 mirMAP -0.118359476413122 0.000294943660548267 NA NA NA hsa-miR-140-5p MCM4 -0.634610285725923 0.126670572966239 4.07456708888893 1.18347519121226e-20 MirTarget -0.179614469050476 0.00532928598284261 NA NA NA hsa-miR-140-5p MDM2 -0.634610285725923 0.126670572966239 1.10063403547143 0.00277879157924784 miRanda -0.133991561849076 0.00853809577209546 NA NA NA hsa-miR-26b-5p MDM2 0.314414148564179 0.461628303578321 1.10063403547143 0.00277879157924784 miRNAWalker2_validate -0.167905763917418 0.00067658693094048 NA NA NA hsa-miR-374b-5p MDM2 -0.114749866169918 0.764888930049438 1.10063403547143 0.00277879157924784 mirMAP -0.202257195528026 0.000245802806142865 NA NA NA hsa-miR-450a-5p MDM2 0.279271977544647 0.642367882565951 1.10063403547143 0.00277879157924784 mirMAP -0.105188175118483 0.00254474898275964 NA NA NA hsa-miR-34a-5p MYC 0.830377770217786 0.0477544831885907 -0.745260197790044 0.453852120838847 miRNAWalker2_validate;miRTarBase -0.427487830189717 0.00161403194033986 25572695;25686834;21460242;22159222;23640973;22830357;22235332 The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;miR 34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c Myc pathway;Myc mediated repression of microRNA 34a promotes high grade transformation of B cell lymphoma by dysregulation of FoxP1;MicroRNA 34a suppresses malignant transformation by targeting c Myc transcriptional complexes in human renal cell carcinoma; We investigated the functional effects of microRNA-34a miR-34a on c-Myc transcriptional complexes in renal cell carcinoma; miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region which was revealed by luciferase reporter assays; Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription indicating a novel role of miR-34a in the regulation of transcription by c-Myc;Among them miR-34a was also associated with poor prognosis in 2 independent series of leukemic and nodal MCL and in cooperation with high expression of the MYC oncogene;We report that miR-34a did not inhibit cell proliferation notwithstanding a marked down-regulation of c-MYC;MicroRNA 34a modulates c Myc transcriptional complexes to suppress malignancy in human prostate cancer cells; We studied the functional effects of miR-34a on c-Myc transcriptional complexes in PC-3 prostate cancer cells; miR-34a downregulated expression of c-Myc oncogene by targeting its 3' UTR as shown by luciferase reporter assays; This is the first report to document that miR-34a suppresses assembly and function of the c-Myc-Skp2-Miz1 complex that activates RhoA and the c-Myc-pTEFB complex that elongates transcription of various genes suggesting a novel role of miR-34a in the regulation of transcription by c-Myc complex ;;;malignant trasformation;worse prognosis;; bladder cancer;liver cancer;B cell lymphoma;kidney renal cell cancer;lymphoma;lymphoma;prostate cancer hsa-miR-429 MYC 6.39965293994036 1.96920201593608e-18 -0.745260197790044 0.453852120838847 miRNAWalker2_validate -0.351232938868747 9.84375821791447e-07 21684154;24633485 miR 429 modulates the expression of c myc in human gastric carcinoma cells; SGC-7901 gastric cancer cells were transfected with miR-429 mimics and endogenous c-myc expression was detected by western blots; We performed functional assays using the 3'UTR of the c-myc gene as a miR-429 target in a luciferase reporter assay system; miR-429 significantly downregulated endogenous c-myc expression in SGC-7901 cells; Action of miR/429 on c-myc 3'UTR was confirmed; c-myc is an important miR-429 target gene;It is known that miR-429 is down-regulated and functions as a tumor suppressor by targeting c-myc and PLGG1 in gastric and breast cancer ; gastric cancer;sarcoma hsa-miR-30a-5p PCNA -0.768430903969183 0.320487552854215 2.73335198670389 1.37036078211483e-12 miRNAWalker2_validate -0.111427447791644 0.000130266569415098 NA NA NA hsa-miR-100-5p PLK1 -2.83165290318755 0.000582447392959329 5.0074128378632 2.04431852044026e-32 miRNAWalker2_validate;miRTarBase -0.169702812626331 7.11466014076287e-08 21636267;23151088;22246341;23842624;25537513;22120675 Reduced miR 100 expression in cervical cancer and precursors and its carcinogenic effect through targeting PLK1 protein; Through modulating miR-100 expression using miR-100 inhibitor or mimic in vitro cell growth cycle and apoptosis were tested separately by MTT or flow cytometry and meanwhile Polo-like kinase1 PLK1 mRNA and protein expressions were detected by qRT-PCR and immunoblotting; The expression of PLK1 in 125 cervical tissues was also examined by immunohistochemical staining and the correlation between miR-100 and PLK1 expression in the same tissues was analysed; The modulation of miR-100 expression remarkably influenced cell proliferation cycle and apoptosis as well as the level of PLK1 protein but not mRNA in vitro experiments; PLK1 expression was negatively correlated with miR-100 expression in CIN3 and cervical cancer tissues; The reduced miR-100 expression participates in the development of cervical cancer at least partly through loss of inhibition to target gene PLK1 which probably occurs in a relative late phase of carcinogenesis;MicroRNA 100 is a potential molecular marker of non small cell lung cancer and functions as a tumor suppressor by targeting polo like kinase 1; By using microRNA miR target prediction algorithms we identified miR-100 that might potentially bind the 3'-untranslated region of PLK1 transcripts; The purpose of this study was to investigate the roles of miR-100 and its association with PLK1 in NSCLC development; Finally the effects of miR-100 expression on growth apoptosis and cell cycle of NSCLC cells by posttranscriptionally regulating PLK1 expression were determined; Meanwhile miR-100 mimics could significantly inhibit PLK1 mRNA and protein expression and reduce the luciferase activity of a PLK1 3' untranslated region-based reporter construct in A549 cells; Furthermore small interfering RNA siRNA-mediated PLK1 downregulation could mimic the effects of miR-100 mimics while PLK1 overexpression could partially rescue the phenotypical changes of NSCLC cells induced by miR-100 mimics; Our findings indicate that low miR-100 may be a poor prognostic factor for NSCLC patients and functions as a tumor suppressor by posttranscriptionally regulating PLK1 expression;Together these results suggest that low miR-100 expression may be an independent poor prognostic factor and miR-100 can function as a tumor suppressor by targeting PLK1 in human EOCs;In HCC tissues miR-100 expression was inversely correlated with the expression of plk1 protein r = -0.418; P = 0.029; Therefore downregulation of miR-100 was correlated with progressive pathological feature and poor prognosis in HCC patients and miR-100 could function as a tumor suppressor by targeting plk1;Here we show that miR-100 inhibits maintenance and expansion of BrCSCs in basal-like cancer through Polo-like kinase1 Plk1 down-regulation;MiR 100 resensitizes docetaxel resistant human lung adenocarcinoma cells SPC A1 to docetaxel by targeting Plk1; Knock-down of Plk1 which was a direct target of miR-100 yielded similar effects as that of ectopic miR-100 expression; The inverse correlation between miR-100 and Plk1 expression was also detected in nude mice SPC-A1/DTX tumor xenografts and clinical lung adenocarcinoma tissues and was proved to be related with the in vivo response to docetaxel; Thus our results suggested that down-regulation of miR-100 could lead to Plk1 over-expression and eventually to docetaxel chemoresistance of human lung adenocarcinoma tumorigenesis;;;progression;worse prognosis;;drug resistance cervical and endocervical cancer;lung squamous cell cancer;ovarian cancer;liver cancer;breast cancer;lung cancer hsa-miR-101-5p PRKDC -1.41522721523565 0.0166784131265028 1.21608905123513 0.00150939508428576 miRNAWalker2_validate;miRTarBase -0.127088344974267 0.000553082713292195 22014955 Although ectopic miR-101 efficiently decreased the ATM and DNA-PKcs levels and increased the radiosensitization level in H1299 H1975 and A549 cells it did not change the levels of the miR-101 targets or radiosensitivity in H157 cells lung squamous cell cancer hsa-miR-140-5p RAD21 -0.634610285725923 0.126670572966239 0.631092425180577 0.0739339534864039 miRanda -0.144964841390933 0.00283802021915248 NA NA NA hsa-miR-181a-5p RAD21 1.25558293560636 0.00748975499703878 0.631092425180577 0.0739339534864039 MirTarget;miRNATAP -0.113201319083492 0.00802493137072587 NA NA NA hsa-miR-181c-5p RAD21 -0.302833440762172 0.537532549455539 0.631092425180577 0.0739339534864039 MirTarget;miRNATAP -0.117213547783938 0.00420910827884531 NA NA NA hsa-miR-106b-5p RB1 2.80565545918114 1.14547999022566e-09 0.829018740404748 0.105390264359777 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.16042317732856 0.00937327175309839 NA NA NA hsa-miR-1301-3p RB1 2.0309605405243 0.000960892301214288 0.829018740404748 0.105390264359777 MirTarget -0.166091535303864 0.000378342475679667 NA NA NA hsa-miR-186-5p RB1 0.445443449112564 0.185447310527704 0.829018740404748 0.105390264359777 mirMAP -0.250589642955206 0.00447883563490634 NA NA NA hsa-miR-29a-5p RB1 0.0748295222568571 0.884125894063293 0.829018740404748 0.105390264359777 MirTarget -0.193206274299027 0.000660076153083625 NA NA NA hsa-miR-30d-3p RB1 -0.0740421896025512 0.857423650167556 0.829018740404748 0.105390264359777 MirTarget -0.238478201111538 0.000807376823613956 NA NA NA hsa-miR-335-5p RB1 0.167216045757305 0.803897055331049 0.829018740404748 0.105390264359777 miRNAWalker2_validate;miRTarBase;MirTarget -0.149872720206992 0.000493202016600709 NA NA NA hsa-miR-590-3p RB1 2.35429565068338 2.79601879608564e-06 0.829018740404748 0.105390264359777 PITA;miRanda -0.255853237342687 6.08938630664969e-06 NA NA NA hsa-miR-590-5p RB1 1.51400888103768 0.0023888567923017 0.829018740404748 0.105390264359777 miRanda -0.206266341872485 0.000374830788116751 NA NA NA hsa-let-7f-2-3p RBL2 1.02768112108475 0.0787293499732611 -0.290362042828854 0.459600981952894 MirTarget -0.110938571443043 0.00433507096732033 NA NA NA hsa-miR-106b-5p RBL2 2.80565545918114 1.14547999022566e-09 -0.290362042828854 0.459600981952894 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.152134757968797 0.00122146155020016 NA NA NA hsa-miR-130a-5p RBL2 1.58028512890005 0.024346333013728 -0.290362042828854 0.459600981952894 MirTarget -0.10715821321623 0.000810244476557906 NA NA NA hsa-miR-32-3p RBL2 2.20477794939766 0.0392771274032852 -0.290362042828854 0.459600981952894 miRNATAP -0.128572933697516 0.000405541163046317 NA NA NA hsa-miR-335-3p RBL2 1.19503568251824 0.0938852560631551 -0.290362042828854 0.459600981952894 MirTarget -0.116365907107437 0.000164887689801712 NA NA NA hsa-miR-335-5p RBL2 0.167216045757305 0.803897055331049 -0.290362042828854 0.459600981952894 miRNAWalker2_validate -0.145019980739739 9.04060047371642e-06 NA NA NA hsa-miR-590-3p RBL2 2.35429565068338 2.79601879608564e-06 -0.290362042828854 0.459600981952894 miRanda -0.194960999183418 6.4906101255289e-06 NA NA NA hsa-miR-532-3p SFN 0.643755490841218 0.214842585969913 8.01375902962281 1.40931878071373e-13 miRNATAP -0.433062948911213 0.000470253719105129 NA NA NA hsa-miR-30a-5p SKP2 -0.768430903969183 0.320487552854215 2.31166698277274 1.96597848968454e-06 MirTarget;miRNATAP -0.111458066922024 0.00202015288167829 NA NA NA hsa-let-7g-3p SMAD3 2.09736290930341 5.30067796437833e-05 0.160014583572917 0.778517282766047 mirMAP -0.257984897034794 2.44423650375142e-05 NA NA NA hsa-miR-17-5p SMAD3 2.3269271449522 2.13987445663942e-05 0.160014583572917 0.778517282766047 miRNAWalker2_validate -0.165009353618131 0.00461261808419179 NA NA NA hsa-miR-186-5p SMAD3 0.445443449112564 0.185447310527704 0.160014583572917 0.778517282766047 mirMAP -0.742764319550064 2.12349457043014e-15 NA NA NA hsa-miR-188-5p SMAD3 1.39111178824125 0.0251592818948912 0.160014583572917 0.778517282766047 PITA -0.238758119317103 3.46346507109757e-06 NA NA NA hsa-miR-28-5p SMAD3 -0.815636722979196 0.0221199948901761 0.160014583572917 0.778517282766047 miRNATAP -0.238288702750939 0.00948140473131226 NA NA NA hsa-miR-29b-2-5p SMAD3 -0.596051745078872 0.189540844841389 0.160014583572917 0.778517282766047 mirMAP -0.33018047859631 3.00181288669247e-06 NA NA NA hsa-miR-30a-3p SMAD3 -1.22212086897848 0.167565797592104 0.160014583572917 0.778517282766047 mirMAP -0.125743455849957 0.000500972339732145 NA NA NA hsa-miR-30d-3p SMAD3 -0.0740421896025512 0.857423650167556 0.160014583572917 0.778517282766047 mirMAP -0.265215856067837 0.000784444342632096 NA NA NA hsa-miR-32-3p SMAD3 2.20477794939766 0.0392771274032852 0.160014583572917 0.778517282766047 mirMAP -0.139443193805526 0.00854369021916498 NA NA NA hsa-miR-335-3p SMAD3 1.19503568251824 0.0938852560631551 0.160014583572917 0.778517282766047 mirMAP -0.150203529209219 0.000833797912476475 NA NA NA hsa-miR-335-5p SMAD3 0.167216045757305 0.803897055331049 0.160014583572917 0.778517282766047 miRNAWalker2_validate -0.170051000133026 0.000363968836124472 NA NA NA hsa-miR-345-5p SMAD3 2.77314563304336 4.34343702412489e-05 0.160014583572917 0.778517282766047 mirMAP -0.193422457386819 3.24971867546412e-05 NA NA NA hsa-miR-501-5p SMAD3 1.0411896821345 0.0777206709183552 0.160014583572917 0.778517282766047 mirMAP -0.280514332977103 1.82290826802372e-07 NA NA NA hsa-miR-589-3p SMAD3 1.33205316880069 0.052632683806148 0.160014583572917 0.778517282766047 mirMAP -0.202014876353946 1.49389042617214e-05 NA NA NA hsa-miR-616-5p SMAD3 2.48416313933027 0.00318247475868827 0.160014583572917 0.778517282766047 mirMAP -0.241397292057418 2.69938790277874e-07 NA NA NA hsa-miR-671-5p SMAD3 1.48527046124636 0.00686722328347111 0.160014583572917 0.778517282766047 MirTarget -0.193412590030654 0.000928749665735432 NA NA NA hsa-miR-7-1-3p SMAD3 1.43074343339835 0.00471215970502094 0.160014583572917 0.778517282766047 mirMAP -0.168365832898427 0.00819700709319524 NA NA NA hsa-miR-769-5p SMAD3 0.41777775802937 0.343089124193569 0.160014583572917 0.778517282766047 miRNATAP -0.366412732630904 4.82674495052425e-07 NA NA NA hsa-miR-21-3p SMAD4 3.50297439576639 6.39946844099206e-10 -1.1222647897474 0.00638923144286853 mirMAP -0.112729088104479 0.00502861854832022 NA NA NA hsa-miR-27a-3p SMAD4 1.76094007417453 0.000216137556256765 -1.1222647897474 0.00638923144286853 MirTarget -0.132335336531126 0.00695151522053189 NA NA NA hsa-miR-30a-5p STAG1 -0.768430903969183 0.320487552854215 0.504118341404362 0.30978078069324 MirTarget -0.140233506627424 0.00010137252693891 NA NA NA hsa-miR-589-3p STAG1 1.33205316880069 0.052632683806148 0.504118341404362 0.30978078069324 MirTarget -0.135809051584306 0.000915744528572458 NA NA NA hsa-let-7i-3p STAG2 1.40449955926384 0.00856138032420271 0.00865358060879373 0.978365517158607 MirTarget;miRNATAP -0.118188196460825 0.000423286276955194 NA NA NA hsa-miR-29b-3p STAG2 0.666547117072858 0.234055379278093 0.00865358060879373 0.978365517158607 MirTarget;miRNATAP -0.114397747013857 0.000362364793641072 NA NA NA hsa-miR-590-3p STAG2 2.35429565068338 2.79601879608564e-06 0.00865358060879373 0.978365517158607 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.110985721843883 0.00168411639461893 NA NA NA hsa-miR-30a-3p TFDP1 -1.22212086897848 0.167565797592104 1.50707697289792 0.000113581984949159 MirTarget;miRNATAP -0.117651521698128 2.15488096931028e-06 NA NA NA hsa-miR-30a-5p TFDP1 -0.768430903969183 0.320487552854215 1.50707697289792 0.000113581984949159 MirTarget;miRNATAP -0.149270840448017 1.41969345460429e-07 NA NA NA hsa-miR-491-5p TFDP1 0.569358547192776 0.313310594748302 1.50707697289792 0.000113581984949159 miRanda -0.117208486553406 0.00358853398486073 NA NA NA hsa-miR-29b-3p TFDP2 0.666547117072858 0.234055379278093 0.583542516970791 0.178841933686099 mirMAP -0.122653774509804 0.00532669865258013 NA NA NA hsa-miR-320b TFDP2 0.20205459771295 0.727216419960509 0.583542516970791 0.178841933686099 mirMAP -0.115990160924529 0.0064650225557083 NA NA NA hsa-miR-338-3p TFDP2 0.447551118940466 0.558485097370031 0.583542516970791 0.178841933686099 mirMAP -0.109863219136369 0.000597031443960999 NA NA NA hsa-miR-141-3p TGFB2 7.30474126597325 1.45115996357606e-24 -1.43663821995393 0.208151431685717 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.215624739416799 0.00999464963415708 NA NA NA hsa-miR-142-3p TGFB2 4.35304505457969 3.10014573651358e-10 -1.43663821995393 0.208151431685717 miRNATAP -0.239982637825598 0.00829657759355293 NA NA NA hsa-miR-148b-3p TGFB2 1.75622244535669 8.84414356040579e-08 -1.43663821995393 0.208151431685717 MirTarget -0.652112155639784 0.000929853930431754 NA NA NA hsa-miR-200a-3p TGFB2 6.336081120041 4.024313571871e-16 -1.43663821995393 0.208151431685717 MirTarget;miRNATAP -0.351128170275698 7.00885632360109e-06 25813153 Tumor suppressive microRNA 200a inhibits renal cell carcinoma development by directly targeting TGFB2; By performing quantitative real-time PCR ELISA and luciferase reporter assays transforming growth factor beta2 TGFB2 was validated as a direct target gene of miR-200a; Moreover siRNA-mediated knockdown of TGFB2 partially phenocopied the effect of miR-200a overexpression; These results suggest that miR-200a suppresses RCC development via directly targeting TGFB2 indicating that miR-200a may present a novel target for diagnostic and therapeutic strategies in RCC kidney renal cell cancer hsa-miR-203a-3p TGFB2 6.35084246337388 7.89944323347948e-08 -1.43663821995393 0.208151431685717 MirTarget -0.267521839692763 3.62940840958117e-07 NA NA NA hsa-miR-2277-5p TGFB2 3.02139935290539 0.0134629626930938 -1.43663821995393 0.208151431685717 MirTarget -0.249573719882911 0.00777879243940924 NA NA NA hsa-miR-362-5p TGFB2 -1.22309034685697 0.0452665543907975 -1.43663821995393 0.208151431685717 MirTarget -0.314690950040788 0.00297612558507577 NA NA NA hsa-miR-375 TGFB2 3.3784490463318 0.0449946294355695 -1.43663821995393 0.208151431685717 miRNAWalker2_validate -0.113027113272895 0.00302877404950613 NA NA NA hsa-miR-429 TGFB2 6.39965293994036 1.96920201593608e-18 -1.43663821995393 0.208151431685717 miRNATAP -0.317868138018968 0.000128726503171991 NA NA NA hsa-miR-500a-5p TGFB2 0.0170829425378565 0.973960207660626 -1.43663821995393 0.208151431685717 mirMAP -0.329451267369997 0.00832586461531593 NA NA NA hsa-miR-500b-5p TGFB2 0.0167434146432646 0.974498641907253 -1.43663821995393 0.208151431685717 MirTarget -0.327405186316064 0.00868447231417683 NA NA NA hsa-let-7f-1-3p TGFB3 1.61507869803314 0.00069342464777815 -2.17732916051247 0.00128816902304754 MirTarget -0.28544584743246 0.000437940636180159 NA NA NA hsa-miR-151a-5p TGFB3 1.0755926560327 0.00684662665520532 -2.17732916051247 0.00128816902304754 MirTarget -0.500615620870658 2.12682352848945e-07 NA NA NA hsa-miR-629-3p TGFB3 3.48282157979573 4.9176538695908e-08 -2.17732916051247 0.00128816902304754 MirTarget -0.241806561248301 3.8838732840276e-05 NA NA NA hsa-miR-140-5p TTK -0.634610285725923 0.126670572966239 6.17200809754619 1.02416279686047e-42 miRanda;miRNATAP -0.196596686586982 0.00610350815034159 NA NA NA hsa-miR-139-5p WEE1 -2.09475477693654 0.000382570602748311 -0.276557520024856 0.511472572565611 miRanda -0.105718280625835 0.00843201395921927 NA NA NA hsa-miR-146b-5p WEE1 1.87569569182453 0.000737241069698886 -0.276557520024856 0.511472572565611 miRanda -0.210247132325093 5.78825105869611e-07 NA NA NA hsa-miR-155-5p WEE1 2.81443182173772 7.42530504828797e-05 -0.276557520024856 0.511472572565611 miRNAWalker2_validate;MirTarget;miRNATAP -0.114549711541189 0.000519821545290636 NA NA NA hsa-miR-338-3p WEE1 0.447551118940466 0.558485097370031 -0.276557520024856 0.511472572565611 miRanda -0.105576706474914 0.00066486861376906 NA NA NA hsa-miR-181c-5p YWHAB -0.302833440762172 0.537532549455539 0.335869051616385 0.183059097452288 mirMAP -0.125689817265884 1.28469508387139e-05 NA NA NA hsa-miR-181c-5p YWHAG -0.302833440762172 0.537532549455539 0.385447226562581 0.259836541396253 MirTarget;miRNATAP -0.154303477041672 8.85668622972177e-05 NA NA NA hsa-miR-200a-3p YWHAG 6.336081120041 4.024313571871e-16 0.385447226562581 0.259836541396253 MirTarget;miRNATAP -0.102315490044077 1.13196642995869e-05 NA NA NA hsa-miR-200b-3p YWHAG 5.56167217794639 6.43540045061709e-16 0.385447226562581 0.259836541396253 MirTarget;TargetScan -0.11446043266416 1.4853090925883e-05 NA NA NA hsa-miR-30a-5p YWHAG -0.768430903969183 0.320487552854215 0.385447226562581 0.259836541396253 miRNATAP -0.121044963221771 8.71646064734457e-07 NA NA NA hsa-miR-361-3p YWHAG 0.805698609170807 0.0418491665498322 0.385447226562581 0.259836541396253 miRNATAP -0.158816170102406 0.00125725402796885 NA NA NA hsa-miR-103a-3p YWHAH 0.990919087251708 0.00468308601422847 0.13374017455715 0.582343790497203 miRNAWalker2_validate;MirTarget;miRNATAP -0.118934118915957 0.00255872843635267 NA NA NA hsa-miR-125a-5p YWHAZ -1.32352790615388 0.00714301627309467 0.79320742951499 0.0165264552158362 miRanda -0.201268409816025 8.09227898128116e-08 NA NA NA hsa-miR-140-3p YWHAZ -1.9828800596692 8.92876132959514e-08 0.79320742951499 0.0165264552158362 MirTarget;PITA;miRNATAP -0.209328588960889 2.6752974302612e-05 NA NA NA hsa-miR-186-5p YWHAZ 0.445443449112564 0.185447310527704 0.79320742951499 0.0165264552158362 mirMAP -0.186541881236864 0.00102158968605537 NA NA NA hsa-miR-195-3p YWHAZ -2.39100534119332 0.000185405399054065 0.79320742951499 0.0165264552158362 MirTarget -0.10349718609516 0.00037684292135237 NA NA NA hsa-miR-28-5p YWHAZ -0.815636722979196 0.0221199948901761 0.79320742951499 0.0165264552158362 PITA;miRanda;miRNATAP -0.246603493589959 3.00364263847771e-06 NA NA NA hsa-miR-30a-5p YWHAZ -0.768430903969183 0.320487552854215 0.79320742951499 0.0165264552158362 miRNAWalker2_validate;MirTarget;miRNATAP -0.114377769916144 1.71880952710236e-06 NA NA NA hsa-miR-328-3p YWHAZ -0.405365328300136 0.434443269076833 0.79320742951499 0.0165264552158362 MirTarget -0.13309401279703 0.000234142058366856 NA NA NA hsa-miR-3913-5p YWHAZ 0.145645056779437 0.734844256690741 0.79320742951499 0.0165264552158362 MirTarget -0.204232871287809 2.79795865642911e-06 NA NA NA hsa-miR-7-1-3p YWHAZ 1.43074343339835 0.00471215970502094 0.79320742951499 0.0165264552158362 mirMAP -0.120732639494573 0.00108325254319048 NA NA NA