miRNA	gene	miRNA_log2FC	miRNA_pvalue	gene_log2FC	gene_pvalue	interactions	correlation_beta	correlation_pvalue	PMID	evidence	outcome	cancer
hsa-miR-140-5p	BMP2	0.143385978449171	0.723899562274568	-0.352601121717215	0.716398475978717	PITA;miRanda;miRNATAP	-0.441844391854893	0.0330451713481755		NA	NA	NA
hsa-let-7b-3p	CTNNB1	-0.0442183528114781	0.909642071126238	0.303142186306136	0.812647962315501	MirTarget;miRNATAP	-0.208704383498611	0.0081282285422882		NA	NA	NA
hsa-miR-300	CTNNB1	0.0346885197984734	0.923770288941265	0.303142186306136	0.812647962315501	miRanda;miRNATAP	-0.129883718472563	0.0044574525911458		NA	NA	NA
hsa-miR-330-3p	CTNNB1	-0.319628201164605	0.219692725314867	0.303142186306136	0.812647962315501	MirTarget;PITA;miRNATAP	-0.473042925438569	0.00333810490391039		NA	NA	NA
hsa-miR-885-5p	CTNNB1	0.0273130354318769	0.947149754495207	0.303142186306136	0.812647962315501	MirTarget;PITA;miRNATAP	-0.163646575501445	0.0266323356843455		NA	NA	NA
hsa-miR-300	EPB41L5	0.0346885197984734	0.923770288941265	0.233064579875723	0.825282458207692	PITA;miRanda	-0.135189619900319	0.00437622487960904		NA	NA	NA
hsa-miR-575	EPB41L5	-0.179427205917919	0.64355583288098	0.233064579875723	0.825282458207692	MirTarget;miRNATAP	-0.744027520999415	0.00188895206022125		NA	NA	NA
hsa-miR-19b-1-5p	FGFR2	-0.340244840652051	0.191200844611501	0.798686888252823	0.485671503052868	miRNAWalker2_validate;miRTarBase	-0.575813845528365	0.000413281652213		NA	NA	NA
hsa-miR-182-5p	FOXF2	-0.172939649217687	0.565173054528098	0.0584874397782187	0.956414758590191	miRNAWalker2_validate;miRNATAP	-0.297455657298587	0.00396797508330477	25738520	miR 182 promotes cell growth and invasion by targeting forkhead box F2 transcription factor in colorectal cancer; In the present study we aimed to investigate the role of miR-182 in colorectal cancer CRC and identify the regulation of FoxF2 by miR-182; The direct binding of miR-182 to the 3' untranslated region 3'UTR of FoxF2 mRNA was confirmed using a luciferase reporter gene assay		colorectal cancer
hsa-miR-429	FOXF2	0.072973940838073	0.868454397928992	0.0584874397782187	0.956414758590191	PITA;miRanda;miRNATAP	-0.096315986074396	0.0401154815013341		NA	NA	NA
hsa-miR-96-5p	FOXF2	0.0123844250472605	0.974683258668689	0.0584874397782187	0.956414758590191	TargetScan;miRNATAP	-0.270498196646838	0.021994163040794		NA	NA	NA
hsa-miR-320a	GSK3B	0.00639817893233108	0.988034778617141	0.0847861762551645	0.941394541317824	miRanda;mirMAP	-1.13137854932489	0.00562532620100888		NA	NA	NA
hsa-miR-141-3p	HGF	-0.0167721315685543	0.971860608809456	0.19579037803443	0.801923418916854	MirTarget;TargetScan	-1.89321309588571	2.27104759119354e-10		NA	NA	NA
hsa-miR-16-2-3p	HIF1A	-0.299692538873426	0.301607324401587	0.632652899664741	0.586205425361515	MirTarget;mirMAP	-0.569701984476101	0.00352354931957875		NA	NA	NA
hsa-let-7a-5p	HMGA2	0.106682152481878	0.827398540405642	-0.225901117544977	0.758428874499262	miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan	-0.649193155363772	0.00021266122200112	20949044;18413822;23073586;21598109;24612219;23134218;23700794;21412931	Since let-7 miRNAs generally play a tumor-suppressive role as targeting oncogenes such as RAS and HMGA2 our results suggest that AZ-P7a cells release let-7 miRNAs via exosomes into the extracellular environment to maintain their oncogenesis;Recent studies report that HMGA2 is negatively regulated by the let-7 microRNA miRNA family; However no studies have examined the clinical significance of HMGA2 and its relationship to the let-7 miRNA family in gastric cancer; We also did an association study comparing HMGA2 expression and let-7 miRNA family expression in gastric cancer; An inverse correlation between HMGA2 and let-7a was found in gastric cancer cell lines P = 0.08; Furthermore our findings suggest that HMGA2 is negatively regulated by the let-7 miRNA family in human gastric cancer;HMGA2 mRNA and let-7 family microRNA were detected by real time fluorescent quantitative reverse transcription polymerase chain reaction in the corresponding frozen tissues; All let-7 family members were detectable in all ovarian cancer samples and their expression were inversely correlated with HMGA2 mRNA expression r=-0.305P<0.05; The downregulation of let-7 is but not the only mechanism of HMGA2 overexpression in serous ovarian cancer;Role of microRNA let 7 and effect to HMGA2 in esophageal squamous cell carcinoma; To investigated the role of microRNA miRNA let-7 and its regulation on high mobility group A2 HMGA2 protein expression in esophageal squamous cell carcinoma ESCC; To evaluate the role of let-7 and HMGA2 cell proliferations were analyzed with synthetic let-7 mimics- or its inhibitor-transfected cells; The transcription of let-7 inversely correlated with HMGA2 protein; The present results demonstrated that let-7 and HMGA2 involved in ESCC carcinogenesis;HMGA2 is down regulated by microRNA let 7 and associated with epithelial mesenchymal transition in oesophageal squamous cell carcinomas of Kazakhs; To investigate the expression of let-7 and its regulation of high-mobility group A2 protein HMGA2 and to verify the relationship between let-7 HMGA2 and the process of epithelial-mesenchymal transition EMT in oesophageal squamous cell carcinomas OSCC of Kazakh patients; Let-7 could repress expression of HMGA2 after co-transfection with let-7 and HMGA2 P = 0.002; Moreover let-7 expression was observed less frequently P = 2.0 × 10-8  and HMGA2 expression more frequently P = 1.0 × 10-10  in OSCC than in normal adjacent tissues; and let-7 expression was observed less frequently in OSCC from Kazakh patients than in those from Han and Uygur patients P = 0.041; There was a reverse correlation between expression of let-7 and HMGA2 P = 0.018; Expression of let-7 can suppress cell proliferation by acting directly on regulation of HMGA2 in OSCC;MicroRNA let 7a inhibits the proliferation and invasion of nonsmall cell lung cancer cell line 95D by regulating K Ras and HMGA2 gene expression; K-RAS and HMGA2 mRNA levels were significantly higher in the let-7a overexpressed group than those in the let-7a inhibited group p < 0.05; However the protein levels of K-RAS and HMGA2 were significantly lower in the let-7a overexpressed group than those in the let-7a inhibited group p < 0.05; We suppose that let-7a inhibits the proliferation and invasion of the cell line 95D by regulating the translation of K-RAS and HMGA2 mRNA not the transcription of the mRNA itself;MiR-98 a member in the let-7 family acts as a negative regulator in the expression of HMGA2 high mobility group A2 oncogene and it has been shown to have a nearly 3-fold decrease in A549/DDP cells;Let 7 microRNA and HMGA2 levels of expression are not inversely linked in adipocytic tumors: analysis of 56 lipomas and liposarcomas with molecular cytogenetic data; The aim of our study was first to assess the role of HMGA2 expression in the pathogenesis of adipocytic tumors AT and second to seek a potential correlation between overexpression of HMGA2 and let-7 expression inhibition by analyzing a series of 56 benign and malignant AT with molecular cytogenetic data; We measured the levels of expression of HMGA2 mRNA and of eight members of the let-7 microRNA family using quantitative RT-PCR and expression of HMGA2 protein using immunohistochemistry; Although overexpression of both HMGA2 mRNA and protein in a majority of ordinary lipomas without HMGA2 structural rearrangement may have suggested a potential role for let-7 microRNAs we did not observe a significant link with let-7 inhibition in such cases	;;;tumorigenesis;;;;malignant trasformation	gastric cancer;gastric cancer;ovarian cancer;esophageal cancer;esophageal cancer;lung squamous cell cancer;lung cancer;sarcoma
hsa-let-7c-5p	HMGA2	0.083771128049615	0.860875870913634	-0.225901117544977	0.758428874499262	miRNAWalker2_validate;miRTarBase;MirTarget	-1.02363288467003	6.35470531351958e-05		NA	NA	NA
hsa-let-7d-5p	HMGA2	0.141494739955818	0.745806520791796	-0.225901117544977	0.758428874499262	miRNAWalker2_validate;miRTarBase;MirTarget	-0.543133400140959	4.66822905075331e-05		NA	NA	NA
hsa-let-7e-5p	HMGA2	0.232688915263049	0.601029286957534	-0.225901117544977	0.758428874499262	miRNAWalker2_validate;miRTarBase;MirTarget	-0.52823843605824	1.15315019164672e-06		NA	NA	NA
hsa-let-7f-5p	HMGA2	0.133315440375512	0.781915132112152	-0.225901117544977	0.758428874499262	miRNAWalker2_validate;MirTarget	-0.575893681934394	0.000151094104963901		NA	NA	NA
hsa-miR-107	HMGA2	0.0308776827384851	0.945619463003008	-0.225901117544977	0.758428874499262	PITA;miRanda	-0.787474753946097	0.00156553780016479		NA	NA	NA
hsa-miR-125b-5p	HMGA2	0.234841483821397	0.637286181742378	-0.225901117544977	0.758428874499262	miRNAWalker2_validate;miRTarBase	-0.819192087676924	6.33214417530433e-06		NA	NA	NA
hsa-miR-142-3p	HMGA2	0.149550697205383	0.730962084397689	-0.225901117544977	0.758428874499262	PITA;miRanda;miRNATAP	-0.299087817593694	0.0132663285435198		NA	NA	NA
hsa-miR-15a-5p	HMGA2	0.11447280989984	0.798783814928843	-0.225901117544977	0.758428874499262	miRTarBase;MirTarget	-0.827864086077722	9.36441117161241e-06		NA	NA	NA
hsa-miR-16-5p	HMGA2	0.110547270063341	0.811290608673229	-0.225901117544977	0.758428874499262	miRTarBase;MirTarget	-0.818135552404968	3.19542653645403e-06		NA	NA	NA
hsa-miR-17-5p	HMGA2	0.0678883386325095	0.874643077251886	-0.225901117544977	0.758428874499262	TargetScan;miRNATAP	-0.424926971838579	0.0306935500683935		NA	NA	NA
hsa-miR-26a-5p	HMGA2	0.107736620749629	0.825248709182534	-0.225901117544977	0.758428874499262	miRNAWalker2_validate;miRTarBase;miRNATAP	-1.52731583129614	1.84925575665272e-08	24682444	Furthermore we demonstrated that high mobility group AT-hook 2 HMGA2 was a direct target of miR-26a; The results showed that HMGA2 mRNA levels and miR-26a levels were negatively correlated; In addition we confirmed that reintroduction of HMGA2 antagonized the inhibition of miR-26a to GBC cell proliferation and all these effects were achieved through the cell cycle; Together all these results suggest that miR-26a expression contributes to GBC proliferation by targeting HMGA2 miR-26a shows promise as a prognosis factor and therapeutic target of GBC patients	worse prognosis	bladder cancer
hsa-miR-361-5p	HMGA2	0.0251354449094356	0.952067342940419	-0.225901117544977	0.758428874499262	PITA;miRanda	-0.963598281756989	0.00114278116506079		NA	NA	NA
hsa-miR-98-5p	HMGA2	0.191889374070866	0.61657188647346	-0.225901117544977	0.758428874499262	miRNAWalker2_validate;miRTarBase;MirTarget	-0.347922923261301	0.000198027466241082	17222355;23700794	Here we report that HMGA2 expression in head and neck squamous cell carcinoma HNSCC cells is regulated in part by miRNA-98 miR-98;MicroRNA 98 sensitizes cisplatin resistant human lung adenocarcinoma cells by up regulation of HMGA2; MiR-98 a member in the let-7 family acts as a negative regulator in the expression of HMGA2 high mobility group A2 oncogene and it has been shown to have a nearly 3-fold decrease in A549/DDP cells; We found that elevated expression of miR-98 led to a higher sensitivity of A549/DDP cells to cisplatin and the protein level of HMGA2 was clearly up-regulated in both A549/DDP and A549 cells by miR-98; We for the first time demonstrated that the expression of miR-98 increases cells spontaneous apoptosis and sensitizes cells to cisplatin at least in part via HMGA2 up-regulation	;	head and neck cancer;lung cancer
hsa-miR-548d-5p	LEF1	-0.0681776125747064	0.853881322133046	0.0498628035893933	0.956260829451938	PITA;miRNATAP	-0.119598777267691	0.0461194799491978		NA	NA	NA
hsa-miR-557	LEF1	0.00233123018280557	0.994932666295757	0.0498628035893933	0.956260829451938	PITA;miRNATAP	-0.886658114235363	0.00242657709494382		NA	NA	NA
hsa-miR-548d-5p	LIMS1	-0.0681776125747064	0.853881322133046	0.267653525819123	0.810079179394092	mirMAP;miRNATAP	-0.0914469883436659	0.0343875210344409		NA	NA	NA
hsa-miR-125a-5p	LOXL3	0.141951416450433	0.735045885048977	-0.150724647051352	0.881146092279706	PITA;miRanda	-0.367630974914019	0.0102071792492917		NA	NA	NA
hsa-miR-34a-5p	LOXL3	0.0836395360426248	0.853590598323296	-0.150724647051352	0.881146092279706	MirTarget;miRNATAP	-0.612276025426386	0.0323735880876357		NA	NA	NA
hsa-miR-126-5p	NOG	0.148557855500191	0.682823295506168	-0.197357758188542	0.843859591660115	mirMAP;miRNATAP	-0.243751478832552	0.0367133172942536		NA	NA	NA
hsa-miR-148a-3p	NOG	0.176028701345531	0.70181594980135	-0.197357758188542	0.843859591660115	MirTarget;miRNATAP	-0.468518509422389	0.00602278730325372		NA	NA	NA
hsa-miR-362-3p	NOG	0.225651175071285	0.531476313631242	-0.197357758188542	0.843859591660115	miRanda;miRNATAP	-0.340031283778404	0.0103500694104705		NA	NA	NA
hsa-miR-10b-3p	RBPJ	-0.25070530064454	0.345566925008693	0.199587728365186	0.851016388146033	MirTarget;miRNATAP	-0.145598814735856	0.0029227845421115		NA	NA	NA
hsa-miR-300	RBPJ	0.0346885197984734	0.923770288941265	0.199587728365186	0.851016388146033	MirTarget;miRanda;miRNATAP	-0.0570858521792189	0.0200285657123328		NA	NA	NA
hsa-miR-491-5p	RBPJ	-0.67430878798915	0.00264060864716318	0.199587728365186	0.851016388146033	MirTarget;miRanda	-0.151925835322605	2.0038858846347e-05		NA	NA	NA
hsa-miR-548c-5p	RBPJ	-0.11981466317418	0.713814357647815	0.199587728365186	0.851016388146033	MirTarget;mirMAP	-0.117140893690497	0.0093314971169812		NA	NA	NA
hsa-miR-30b-5p	SNAI1	0.0690408884646354	0.880662560879576	-0.103093774348326	0.906530660187362	miRTarBase;miRNATAP	-0.578091747620566	0.0412734572802627		NA	NA	NA
hsa-miR-30c-5p	SNAI1	0.154306955189385	0.731574585668277	-0.103093774348326	0.906530660187362	miRTarBase;miRNATAP	-0.806346623742877	0.00119390909185075		NA	NA	NA
hsa-miR-182-5p	SNAI2	-0.172939649217687	0.565173054528098	0.427335037867287	0.715735551409115	miRNAWalker2_validate;miRNATAP	-1.68055873913238	1.64183634806716e-17		NA	NA	NA
hsa-miR-30d-5p	SOX9	-0.0928909858187401	0.83798875180577	0.26432900658016	0.826646415417161	MirTarget;miRNATAP	-1.07070529682389	0.0190150991119518		NA	NA	NA
hsa-miR-130b-3p	TGFB2	-0.175809345914864	0.617072698408832	0.607052011765725	0.596074893581819	MirTarget;miRNATAP	-1.74515690075248	1.75643481040645e-06		NA	NA	NA
hsa-miR-141-3p	TGFB2	-0.0167721315685543	0.971860608809456	0.607052011765725	0.596074893581819	miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP	-4.80745763025493	7.41723915418609e-13		NA	NA	NA
hsa-miR-548c-3p	TGFB2	-0.934954253237028	0.00574489110131836	0.607052011765725	0.596074893581819	MirTarget;mirMAP	-0.200228404492367	1.44323749223248e-05		NA	NA	NA
hsa-miR-330-3p	TGFBR1	-0.319628201164605	0.219692725314867	0.479074327112363	0.690169176896316	mirMAP;miRNATAP	-0.349427191620697	0.0427100176132168		NA	NA	NA
hsa-miR-665	TGFBR1	-0.332945869573742	0.258647216768952	0.479074327112363	0.690169176896316	PITA;miRNATAP	-0.607105557480566	7.83644629320509e-08		NA	NA	NA
hsa-miR-769-5p	TGFBR1	-0.208493563713388	0.532629380293934	0.479074327112363	0.690169176896316	PITA;miRNATAP	-1.14132590420078	8.54978897539202e-06		NA	NA	NA
hsa-miR-96-5p	TGFBR1	0.0123844250472605	0.974683258668689	0.479074327112363	0.690169176896316	TargetScan;miRNATAP	-0.596621514896345	0.00264550091122504		NA	NA	NA
hsa-miR-15b-5p	TGFBR3	-0.0538145308423799	0.901018060527103	0.761083644980872	0.507038281582757	MirTarget;miRNATAP	-1.26169214708664	0.0023959359339784		NA	NA	NA
hsa-miR-330-3p	TGFBR3	-0.319628201164605	0.219692725314867	0.761083644980872	0.507038281582757	MirTarget;PITA;miRNATAP	-0.441012050567386	0.0176777337880997		NA	NA	NA
hsa-miR-484	TGFBR3	-0.156112085608359	0.666252457194413	0.761083644980872	0.507038281582757	MirTarget;miRNATAP	-0.855881040041823	0.0127064996253038		NA	NA	NA
hsa-miR-501-3p	TGFBR3	-0.181742079992225	0.533107948306146	0.761083644980872	0.507038281582757	TargetScan;miRNATAP	-0.502324679779447	0.00554938887800017		NA	NA	NA
hsa-miR-107	WNT4	0.0308776827384851	0.945619463003008	-0.1130322405614	0.906019470194792	PITA;miRNATAP	-0.782213089064737	0.0110930537526163		NA	NA	NA
hsa-miR-30a-5p	WNT5A	0.0110822420913088	0.980691936017938	-0.158475938187074	0.871199079779365	miRNAWalker2_validate;mirMAP	-1.25347066385142	0.0184457660711292		NA	NA	NA
hsa-miR-429	WNT5A	0.072973940838073	0.868454397928992	-0.158475938187074	0.871199079779365	miRanda;miRNATAP	-0.234579035313395	0.0104500913580623		NA	NA	NA