miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7a-5p CSNK2A1 -0.0656092877172174 0.961124733677684 0.0222385179144631 0.968143761360086 miRNAWalker2_validate;TargetScan -0.135347217436861 5.73489571379612e-07 hsa-let-7b-5p CCND3 -0.199052001138817 0.878277241542979 0.0685897951172629 0.90037560215421 miRNAWalker2_validate -0.081899931565498 0.000139976703259041 hsa-let-7b-5p CSNK2A1 -0.199052001138817 0.878277241542979 0.0222385179144631 0.968143761360086 miRNAWalker2_validate -0.0664367896888994 0.00149734249067131 hsa-let-7b-5p CUL1 -0.199052001138817 0.878277241542979 0.0129218624687715 0.981995631753189 miRNAWalker2_validate -0.0549753707390002 0.000326220624123555 hsa-let-7b-5p PLCB3 -0.199052001138817 0.878277241542979 0.118375767075563 0.808132780263958 miRNAWalker2_validate -0.16887583502616 4.06103235376535e-11 hsa-let-7c-5p CSNK2A1 -0.143443180517618 0.886580802063121 0.0222385179144631 0.968143761360086 miRNAWalker2_validate -0.112963831397893 1.45380762126855e-14 hsa-let-7c-5p PPP2R5E -0.143443180517618 0.886580802063121 -0.08594361639783 0.857732462812563 miRNAWalker2_validate -0.0624568555774743 0.000338193301071265 hsa-miR-100-5p CUL1 -0.00806132906517831 0.993876383825125 0.0129218624687715 0.981995631753189 miRNAWalker2_validate -0.0504626168972006 1.12501628264844e-05 hsa-miR-101-3p FZD6 -0.140525462772132 0.906382304639665 -0.169694244565214 0.734859272253398 miRNAWalker2_validate;MirTarget -0.18427726420101 0.00071074749259132 hsa-miR-101-3p RAC1 -0.140525462772132 0.906382304639665 0.0918696560055405 0.901667661189062 miRNAWalker2_validate;MirTarget -0.139972978942608 1.93650351223228e-14 hsa-miR-103a-3p AXIN2 0.0952235048222612 0.939840715516335 -0.0138759668242621 0.966117623520896 miRNAWalker2_validate;MirTarget;miRNATAP -0.200585660302729 7.71528936514313e-05 hsa-miR-103a-3p MAP3K7 0.0952235048222612 0.939840715516335 -0.104962611573905 0.825259838393628 miRNAWalker2_validate -0.184281845409368 2.38036238656993e-13 hsa-miR-106b-5p APC -0.0853499657102335 0.901700669947609 -0.0723635628413355 0.883189867616246 miRNAWalker2_validate;miRTarBase -0.313795610281918 3.20314695735614e-32 23087084 miR-106b downregulates adenomatous polyposis coli and promotes cell proliferation in human hepatocellular carcinoma liver cancer hsa-miR-106b-5p CCND1 -0.0853499657102335 0.901700669947609 0.0138594286077627 0.985644356886489 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.258644062815507 8.24041501542474e-07 23087084 Furthermore miR-106b upregulation in hepatoma cells modulated entry into the G1/S transitional phase by upregulating cyclin D1 and downregulating APC liver cancer hsa-miR-106b-5p CCND2 -0.0853499657102335 0.901700669947609 -0.168931301767903 0.722558871099741 miRNAWalker2_validate;miRTarBase;miRNATAP -0.324304654054346 9.75129599972944e-20 hsa-miR-106b-5p MAPK9 -0.0853499657102335 0.901700669947609 -0.00950322920821378 0.985902275586564 miRNAWalker2_validate;miRNATAP -0.0706276924025854 0.000620207445871053 hsa-miR-10a-5p DVL1 0.255396588065263 0.844875410767462 -0.0106489854425629 0.983281417437041 miRNAWalker2_validate -0.107762545824595 6.19772338888115e-06 hsa-miR-10a-5p MAP3K7 0.255396588065263 0.844875410767462 -0.104962611573905 0.825259838393628 miRNAWalker2_validate;miRTarBase;MirTarget -0.0524078330209384 0.000603693535918827 hsa-miR-10b-5p CSNK2A1 0.0860066308485106 0.952735981646638 0.0222385179144631 0.968143761360086 miRNAWalker2_validate -0.0862473083714623 1.31665372202165e-07 hsa-miR-10b-5p CTBP1 0.0860066308485106 0.952735981646638 -0.00426146109334713 0.994460970584857 miRNAWalker2_validate -0.131124284874422 2.1818976824128e-17 hsa-miR-125b-5p FRAT2 -0.0598851546678105 0.945288350565791 -0.0156891928833645 0.96774417787488 miRNAWalker2_validate;miRNATAP -0.211438805112806 1.43832131405049e-24 hsa-miR-1301-3p CREBBP -0.0935647712087007 0.781492825390485 -0.121528460671809 0.849036225288355 miRNAWalker2_validate -0.0590536076300618 1.60414373280026e-05 hsa-miR-130b-3p SMAD4 -0.211426879967744 0.486104856445712 -0.0337260829637342 0.952673159973339 miRNAWalker2_validate;miRNATAP -0.0969664737937125 1.91848937755898e-09 hsa-miR-140-3p MAPK8 -0.0813609197213889 0.923953795876038 -0.267537090166021 0.457115846208038 miRNAWalker2_validate -0.18488366577202 2.13922359684877e-08 hsa-miR-141-3p TCF7L1 -0.179420502124191 0.83354105481228 -0.1613283678339 0.721505802735508 miRNAWalker2_validate -0.199972471420516 6.28430074006789e-11 hsa-miR-146b-5p RHOA 0.00834882458611474 0.991577009242932 0.0333557466121839 0.967744764731311 miRNAWalker2_validate;miRanda -0.0754485631965621 1.64782584676224e-09 hsa-miR-148b-3p TCF7L2 -0.121415535518017 0.85232232285121 -0.151922190442888 0.739870566881007 miRNAWalker2_validate -0.36003166883339 8.1210275031183e-21 hsa-miR-149-5p FZD5 0.110896382194027 0.854013616827913 -0.186395173219289 0.518902590417545 miRNAWalker2_validate;miRNATAP -0.061736623682236 0.00245478864928029 hsa-miR-149-5p JUN 0.110896382194027 0.854013616827913 -0.108657195258627 0.877583083771737 miRNAWalker2_validate;miRNATAP -0.0680244434441488 0.00220042734644026 hsa-miR-151a-5p SKP1 -0.0279196203281629 0.960899473482335 0.11984894684252 0.870895899955478 miRNAWalker2_validate -0.0670971644303372 0.00149463714411596 hsa-miR-155-5p APC -0.167418736137707 0.822294484498835 -0.0723635628413355 0.883189867616246 miRNAWalker2_validate;miRTarBase;miRNATAP -0.154771290746743 4.27853241366662e-14 hsa-miR-155-5p CCND1 -0.167418736137707 0.822294484498835 0.0138594286077627 0.985644356886489 miRNAWalker2_validate -0.298681895389198 2.32439253453393e-14 hsa-miR-155-5p CSNK1A1 -0.167418736137707 0.822294484498835 -0.0165042555609478 0.982452723332151 miRNAWalker2_validate;miRTarBase;miRNATAP -0.112093319289922 5.71697685710134e-17 hsa-miR-155-5p CTNNB1 -0.167418736137707 0.822294484498835 -0.0805864772545046 0.91992258189981 miRNAWalker2_validate -0.0740110021165611 2.89375498293407e-06 hsa-miR-155-5p JUN -0.167418736137707 0.822294484498835 -0.108657195258627 0.877583083771737 miRNAWalker2_validate;miRTarBase -0.151050894850655 5.76726631886013e-07 26055960;26055960;23693020;23693020 We found in FLT3-mutated AML a significant down-regulation of miR-155 target genes CEBPB and SPI1 and up-regulation of miR-155 regulator genes JUN and RUNX1;Our results suggest that activating mutation of FLT3 in AML can lead through the induction of JUN to an increased expression of miR-155 which then causes down-regulation of SPI1 and CEBPB and consequently may causes block of myeloid differentiation;In the present study we demonstrated for the first time that activation of RAGE by S100P regulates oncogenic microRNA-155 miR-155 expression through Activator Protein-1 AP-1 stimulation in colon cancer cells;Attenuation of AP-1 activation through pharmacological inhibition of MEK activation or genetic inhibition of c-Jun activation using dominant negative c-Jun TAM67 suppressed miR-155 induction by exogenous S100P ;differentiation;;; acute myeloid leukemia;acute myeloid leukemia;colorectal cancer;colorectal cancer hsa-miR-155-5p SMAD3 -0.167418736137707 0.822294484498835 -0.00805727245311783 0.987902560465751 miRNAWalker2_validate -0.161248941325708 6.88088611744894e-17 hsa-miR-155-5p SMAD4 -0.167418736137707 0.822294484498835 -0.0337260829637342 0.952673159973339 miRNAWalker2_validate -0.114314883374695 1.83733755300191e-14 hsa-miR-155-5p WNT5A -0.167418736137707 0.822294484498835 -0.37564066226164 0.355542462686927 miRNAWalker2_validate;mirMAP -0.104443534618959 0.0103110503358659 hsa-miR-15a-5p BTRC 0.027476192963463 0.965257307327948 -0.113796391872094 0.818463431452382 miRNAWalker2_validate;MirTarget;miRNATAP -0.190986059010062 3.25059412787152e-09 hsa-miR-15a-5p CCND2 0.027476192963463 0.965257307327948 -0.168931301767903 0.722558871099741 miRNAWalker2_validate;miRTarBase;miRNATAP -0.382989347535057 1.85935181542133e-19 hsa-miR-15a-5p JUN 0.027476192963463 0.965257307327948 -0.108657195258627 0.877583083771737 miRNAWalker2_validate -0.11719036255872 0.0145941714826506 hsa-miR-15b-5p CCND1 0.0382341477298391 0.953925647243518 0.0138594286077627 0.985644356886489 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.125463191460891 0.00921827566968511 hsa-miR-16-5p AXIN2 -0.131938295863899 0.869419037928521 -0.0138759668242621 0.966117623520896 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.250388265601038 2.07986806159543e-08 hsa-miR-16-5p BTRC -0.131938295863899 0.869419037928521 -0.113796391872094 0.818463431452382 miRNAWalker2_validate;MirTarget;miRNATAP -0.0769482317384334 0.00978479180103888 hsa-miR-16-5p CCND2 -0.131938295863899 0.869419037928521 -0.168931301767903 0.722558871099741 miRNAWalker2_validate;miRNATAP -0.126011969570663 0.00149555991801246 hsa-miR-16-5p JUN -0.131938295863899 0.869419037928521 -0.108657195258627 0.877583083771737 miRNAWalker2_validate -0.336111932326481 7.47849859844435e-15 hsa-miR-16-5p WNT3A -0.131938295863899 0.869419037928521 0.492064690202575 0.228807004551161 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.223562434556754 0.00686252591255575 hsa-miR-16-5p WNT5A -0.131938295863899 0.869419037928521 -0.37564066226164 0.355542462686927 miRNAWalker2_validate -0.443371863255678 2.01154967356747e-14 hsa-miR-17-5p CCND1 -0.0085894792332244 0.990927211793889 0.0138594286077627 0.985644356886489 miRNAWalker2_validate;MirTarget;TargetScan;miRNATAP -0.23795787679729 6.72139201694027e-09 18695042 Mammary epithelial cell-targeted cyclin D1 expression induced miR-17-5p and miR-20a expression in vivo and cyclin D1 bound the miR-17/20 cluster promoter regulatory region breast cancer hsa-miR-17-5p CCND2 -0.0085894792332244 0.990927211793889 -0.168931301767903 0.722558871099741 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.218141508896336 9.56625930755479e-15 hsa-miR-17-5p MAPK9 -0.0085894792332244 0.990927211793889 -0.00950322920821378 0.985902275586564 miRNAWalker2_validate;miRTarBase;miRNATAP -0.0889160251990861 3.31917858950972e-08 hsa-miR-17-5p SMAD3 -0.0085894792332244 0.990927211793889 -0.00805727245311783 0.987902560465751 miRNAWalker2_validate -0.144062907194855 1.0396353881575e-12 hsa-miR-181b-5p EP300 0.0375130667115933 0.959555096276237 -0.0381739592699031 0.951249053975231 miRNAWalker2_validate -0.187884049605316 7.93444158362854e-15 hsa-miR-181d-5p EP300 -0.116844052208921 0.774221578291478 -0.0381739592699031 0.951249053975231 miRNAWalker2_validate -0.0806657047344004 0.000232482413294744 hsa-miR-182-5p CCND2 -0.101509746042318 0.939206381321837 -0.168931301767903 0.722558871099741 miRNAWalker2_validate;miRTarBase;miRNATAP -0.333755066801542 7.98233999507297e-38 hsa-miR-182-5p SMAD4 -0.101509746042318 0.939206381321837 -0.0337260829637342 0.952673159973339 miRNAWalker2_validate -0.065780984206604 1.05695211333097e-05 23226455;23226455 MiR-182-5p also increased nuclear beta-catenin expression and while Smad4 repressed nuclear beta-catenin expression;In conclusion our data suggests that miR-182-5p plays an important role as an oncogene by knocking down RECK and Smad4 resulting in activation of the Wnt-beta-catenin signaling pathway in bladder cancer ; bladder cancer;bladder cancer hsa-miR-186-5p CAMK2B -0.14779866926096 0.840248407765158 0.141283778852512 0.60471522191955 miRNAWalker2_validate;miRNATAP -0.420009924398004 3.08262880687716e-06 hsa-miR-186-5p CSNK1A1 -0.14779866926096 0.840248407765158 -0.0165042555609478 0.982452723332151 miRNAWalker2_validate;miRNATAP -0.111953585604854 1.83989613326677e-08 hsa-miR-186-5p WNT5A -0.14779866926096 0.840248407765158 -0.37564066226164 0.355542462686927 miRNAWalker2_validate;mirMAP;miRNATAP -0.302944959464288 3.52342706593741e-07 hsa-miR-18a-5p DAAM2 -0.060215066151506 0.836155187457355 -0.0621191173439439 0.879009045386603 miRNAWalker2_validate -0.128936539387179 3.13505694340858e-06 hsa-miR-18a-5p SMAD3 -0.060215066151506 0.836155187457355 -0.00805727245311783 0.987902560465751 miRNAWalker2_validate -0.145191271950291 4.28063578565896e-20 hsa-miR-18a-5p SMAD4 -0.060215066151506 0.836155187457355 -0.0337260829637342 0.952673159973339 miRNAWalker2_validate -0.0635830061103925 2.8499707420967e-07 hsa-miR-192-5p FZD1 -0.13549863762303 0.859625790519489 -0.147165722412794 0.785892420221886 miRNAWalker2_validate -0.0557666617319101 0.0490966929020662 hsa-miR-192-5p FZD4 -0.13549863762303 0.859625790519489 0.0304707076358319 0.955399406040093 miRNAWalker2_validate;mirMAP -0.417317983267879 3.23659392050309e-28 hsa-miR-192-5p FZD7 -0.13549863762303 0.859625790519489 -0.175347860746907 0.737019399304957 miRNAWalker2_validate -0.161936601307415 7.47545781365299e-06 hsa-miR-192-5p PRICKLE1 -0.13549863762303 0.859625790519489 -0.101221821514089 0.815959595958142 miRNAWalker2_validate -0.0710131909431695 0.0368322647258242 hsa-miR-192-5p TCF7 -0.13549863762303 0.859625790519489 -0.190752137435303 0.611949137914896 miRNAWalker2_validate;MirTarget -0.086918829705449 0.0269568258565568 hsa-miR-193b-3p PRKCA -0.258193381252116 0.674998055533564 -0.227245147154052 0.467261641689546 miRNAWalker2_validate -0.158591304154604 9.61914010087921e-05 hsa-miR-193b-3p RAC2 -0.258193381252116 0.674998055533564 -0.0700678223375455 0.877994799861163 miRNAWalker2_validate -0.163439972898065 2.05534635731132e-06 hsa-miR-196a-5p CCND1 0.146453702879546 0.847380846257138 0.0138594286077627 0.985644356886489 miRNAWalker2_validate -0.0514129723767711 0.012488774926187 hsa-miR-197-3p PPP2CA -0.16253774958271 0.828233346204688 0.0284217367477391 0.96534362029265 miRNAWalker2_validate -0.0684429042690927 6.64329770244068e-06 hsa-miR-19a-3p CCND1 -0.00951638786771092 0.980991306004163 0.0138594286077627 0.985644356886489 miRNAWalker2_validate;miRTarBase;miRNATAP -0.216023850578105 8.24189814452405e-09 25985117 Moreover miR-19a might play inhibitory roles in HCC malignancy via regulating Cyclin D1 expression liver cancer hsa-miR-19b-1-5p CCND1 -0.126966953724701 0.619571308879527 0.0138594286077627 0.985644356886489 miRNAWalker2_validate;miRTarBase -0.206802040114629 3.03348057195458e-06 hsa-miR-19b-3p CCND2 -0.0314903804749491 0.95913844863355 -0.168931301767903 0.722558871099741 miRNAWalker2_validate;MirTarget;miRNATAP -0.166767747836903 1.62862778749919e-07 hsa-miR-19b-3p DAAM2 -0.0314903804749491 0.95913844863355 -0.0621191173439439 0.879009045386603 miRNAWalker2_validate -0.131066070980346 0.000861544162814882 hsa-miR-19b-3p PRKACB -0.0314903804749491 0.95913844863355 -0.0742837105484302 0.886731753016865 miRNAWalker2_validate;MirTarget;miRNATAP -0.13474256019019 0.00164169207970928 hsa-miR-200a-3p SMAD3 -0.192839143060886 0.77994979695622 -0.00805727245311783 0.987902560465751 miRNAWalker2_validate -0.0959665084573349 5.0161067163894e-10 hsa-miR-200a-3p TCF7L1 -0.192839143060886 0.77994979695622 -0.1613283678339 0.721505802735508 miRNAWalker2_validate -0.150558299078396 6.03400969336786e-07 hsa-miR-200b-3p EP300 -0.109983892590611 0.891357972128093 -0.0381739592699031 0.951249053975231 miRNAWalker2_validate;TargetScan -0.0525756044353262 0.00290527970960469 hsa-miR-200b-3p TCF7L1 -0.109983892590611 0.891357972128093 -0.1613283678339 0.721505802735508 miRNAWalker2_validate -0.168143697293025 5.41553060367198e-07 hsa-miR-200c-3p RHOA -0.0449560636499466 0.969433069399071 0.0333557466121839 0.967744764731311 miRNAWalker2_validate;MirTarget;miRNATAP -0.0617829868328387 5.83761671382278e-10 hsa-miR-200c-3p TCF7L1 -0.0449560636499466 0.969433069399071 -0.1613283678339 0.721505802735508 miRNAWalker2_validate -0.229533628135833 4.20710186780113e-10 hsa-miR-20a-5p CCND1 0.0648697217907399 0.924634007033878 0.0138594286077627 0.985644356886489 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.218045690926451 3.58399990050218e-07 hsa-miR-20a-5p CCND2 0.0648697217907399 0.924634007033878 -0.168931301767903 0.722558871099741 miRNAWalker2_validate;miRTarBase;miRNATAP -0.235095611327971 1.01223581717651e-15 hsa-miR-20a-5p MAPK9 0.0648697217907399 0.924634007033878 -0.00950322920821378 0.985902275586564 miRNAWalker2_validate;miRNATAP -0.149791797617831 1.16802726117118e-19 hsa-miR-21-5p APC 0.0148493782366828 0.992419670576308 -0.0723635628413355 0.883189867616246 miRNAWalker2_validate -0.246283784759972 7.23712061544539e-21 hsa-miR-21-5p DAAM1 0.0148493782366828 0.992419670576308 -0.0539991515887506 0.906596879539895 miRNAWalker2_validate -0.280306110680269 1.3190405082497e-14 hsa-miR-21-5p MYC 0.0148493782366828 0.992419670576308 0.0371115296700548 0.951416673961988 miRNAWalker2_validate -0.270190862069706 5.76701615920235e-10 hsa-miR-21-5p NFAT5 0.0148493782366828 0.992419670576308 -0.140634566870934 0.80102714017311 miRNAWalker2_validate;mirMAP -0.34259926440926 2.90805980799457e-41 hsa-miR-21-5p PRICKLE2 0.0148493782366828 0.992419670576308 0.0177255412987654 0.969497997086328 miRNAWalker2_validate;MirTarget -0.342742077988917 1.89622326605409e-18 hsa-miR-214-3p MAPK8 -0.110449829460212 0.670567263185672 -0.267537090166021 0.457115846208038 miRNAWalker2_validate -0.131663145030191 2.77448993612092e-07 19859982;19859982 HeLa cells that stably overexpress miR-214 downregulate the expression of MEK3 and JNK1 at both mRNA and protein levels;Further investigation revealed that miR-214 regulates the expression of MEK3 and JNK1 by targeting the 3'UTRs of these genes ; cervical and endocervical cancer;cervical and endocervical cancer hsa-miR-215-5p NLK -0.130652000561099 0.59456440396631 -0.0075726819422437 0.986090753913933 miRNAWalker2_validate -0.0752616706178515 1.58859163631704e-05 hsa-miR-215-5p WNT3 -0.130652000561099 0.59456440396631 -0.0153912479566303 0.926692523100822 miRNAWalker2_validate -0.202617944190342 6.29886106348422e-08 hsa-miR-22-3p FRAT2 -0.0230458302155654 0.987273023087919 -0.0156891928833645 0.96774417787488 miRNAWalker2_validate;MirTarget;miRNATAP -0.282270676456224 8.71182980194614e-13 hsa-miR-221-3p DKK2 -0.0578227721969284 0.924067621219326 0.299403293390667 0.169274319749997 miRNAWalker2_validate;miRTarBase -0.155357098507464 0.000547828614406337 hsa-miR-222-3p PPP2R1A -0.0901542670760289 0.851836230793884 0.0981760857696141 0.894638367692319 miRNAWalker2_validate -0.0927977383263943 2.69520975624089e-09 hsa-miR-23a-3p NLK -0.0749136181048318 0.942312664607036 -0.0075726819422437 0.986090753913933 miRNAWalker2_validate;MirTarget -0.089740782116192 0.00430248288070416 hsa-miR-24-3p CHD8 -0.156339520113363 0.865374272536865 -0.0178510158573202 0.976383552659853 miRNAWalker2_validate -0.0887261371614656 2.04661405682115e-06 hsa-miR-25-3p EP300 0.0550592306329012 0.962829613775088 -0.0381739592699031 0.951249053975231 miRNAWalker2_validate -0.101950779775411 0.00585001386907759 hsa-miR-26a-5p GSK3B -0.0558466394626773 0.953979749143751 -0.0660851428212252 0.908304623747486 miRNAWalker2_validate;miRNATAP -0.275908606747704 3.58443650423207e-22 hsa-miR-26b-5p DVL3 -0.165683456923659 0.842739329770527 0.00975763465514845 0.987406911304736 miRNAWalker2_validate -0.0578667127916807 0.000851563132011107 hsa-miR-26b-5p RUVBL1 -0.165683456923659 0.842739329770527 0.132172450685464 0.800766443652738 miRNAWalker2_validate -0.0786718409147151 0.00463723538327377 hsa-miR-26b-5p VANGL1 -0.165683456923659 0.842739329770527 -0.0952455706302153 0.850760454545912 miRNAWalker2_validate;mirMAP -0.0762100023478852 0.0109822049419944 hsa-miR-27a-3p APC -0.0713791016390708 0.936296470694396 -0.0723635628413355 0.883189867616246 miRNAWalker2_validate;miRTarBase;miRNATAP -0.178295160206353 5.95535983433013e-08 hsa-miR-27b-3p MAPK9 -0.113933322553999 0.889976675583125 -0.00950322920821378 0.985902275586564 miRNAWalker2_validate -0.0863588759919054 0.000169615182610155 hsa-miR-29a-3p SFRP2 -0.173904473376583 0.873886834369773 -0.000608038423459689 0.999366127714656 miRNAWalker2_validate;miRTarBase -0.155587096466859 0.0276230069718623 hsa-miR-29b-3p CTNNBIP1 -0.147629200668355 0.855068431567557 -0.0617522470279912 0.902562563271752 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.0514196528863894 0.0235383940104348 hsa-miR-301a-3p CCND2 -0.0522829902990942 0.861546852981366 -0.168931301767903 0.722558871099741 miRNAWalker2_validate -0.182363632693643 1.4299291622836e-15 hsa-miR-30a-5p PPP3R1 -0.315304933842571 0.81611555406281 -0.0271826487262787 0.962679518571233 miRNAWalker2_validate;MirTarget;miRNATAP -0.13382780475557 1.01801426792285e-27 hsa-miR-320a DVL3 0.0425274543382255 0.958191670788918 0.00975763465514845 0.987406911304736 miRNAWalker2_validate;miRanda -0.0647009875481706 0.000461763551344418 hsa-miR-320a FRAT2 0.0425274543382255 0.958191670788918 -0.0156891928833645 0.96774417787488 miRNAWalker2_validate -0.0811904110294671 0.00817423633442612 hsa-miR-324-3p CCND2 -0.0533960575545418 0.892365633037602 -0.168931301767903 0.722558871099741 miRNAWalker2_validate -0.187482582074807 4.91214943402943e-08 hsa-miR-324-3p CSNK1A1 -0.0533960575545418 0.892365633037602 -0.0165042555609478 0.982452723332151 miRNAWalker2_validate -0.0597502806566695 0.000494860297661723 hsa-miR-335-5p AXIN1 -0.0216107337976461 0.95157247156319 -0.0653528137130222 0.894667807615627 miRNAWalker2_validate -0.142684376401892 7.8023220735108e-23 hsa-miR-335-5p WNT3 -0.0216107337976461 0.95157247156319 -0.0153912479566303 0.926692523100822 miRNAWalker2_validate -0.0769363232909401 0.0119628047493477 hsa-miR-335-5p WNT7B -0.0216107337976461 0.95157247156319 0.203059513313665 0.583576542147028 miRNAWalker2_validate -0.23895557225465 6.17708068119425e-09 hsa-miR-335-5p WNT9A -0.0216107337976461 0.95157247156319 -0.0458266531912801 0.800227025121973 miRNAWalker2_validate -0.146714794864289 9.92998698360538e-06 hsa-miR-342-3p CCND2 -0.244092268513731 0.741215180994683 -0.168931301767903 0.722558871099741 miRNAWalker2_validate;mirMAP -0.103848624831325 0.000189231379572542 hsa-miR-342-3p JUN -0.244092268513731 0.741215180994683 -0.108657195258627 0.877583083771737 miRNAWalker2_validate -0.199604605467411 5.91888161762324e-11 hsa-miR-34a-5p CTNNB1 -0.00150684423480296 0.998107346259152 -0.0805864772545046 0.91992258189981 miRNAWalker2_validate -0.0614881341139617 0.0202164418517387 hsa-miR-34a-5p MYC -0.00150684423480296 0.998107346259152 0.0371115296700548 0.951416673961988 miRNAWalker2_validate;miRTarBase -0.216308870548993 0.000129276161670072 22235332;22235332;22235332;22235332;22159222;22159222;22159222;22159222 MicroRNA-34a modulates c-Myc transcriptional complexes to suppress malignancy in human prostate cancer cells;miR-34a downregulated expression of c-Myc oncogene by targeting its 3' UTR as shown by luciferase reporter assays;Overexpression of c-Myc reversed miR-34a suppression of RhoA expression suggesting that miR-34a inhibits invasion by suppressing RhoA through c-Myc miR-34a was also found to repress c-Myc-pTEFB transcription elongation complex indicating one of the mechanisms by which miR-34a has profound effects on cellular function;This is the first report to document that miR-34a suppresses assembly and function of the c-Myc-Skp2-Miz1 complex that activates RhoA and the c-Myc-pTEFB complex that elongates transcription of various genes suggesting a novel role of miR-34a in the regulation of transcription by c-Myc complex;MicroRNA-34a suppresses malignant transformation by targeting c-Myc transcriptional complexes in human renal cell carcinoma;miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region which was revealed by luciferase reporter assays;Overexpression of c-Myc reversed miR-34a suppression of RhoA expression and inhibition of cell invasion suggesting that miR-34a inhibits invasion by suppressing RhoA through c-Myc miR-34a was also found to repress the c-Myc-P-TEFb transcription elongation complex indicating one of the mechanisms by which miR-34a has profound effects on cellular functions;Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription indicating a novel role of miR-34a in the regulation of transcription by c-Myc ;;invasion;;;malignant trasformation;;;invasion;; prostate cancer;prostate cancer;prostate cancer;prostate cancer;renal cell cancer;renal cell cancer;renal cell cancer;renal cell cancer hsa-miR-365a-3p VANGL1 0.0307303320006067 0.959616484776468 -0.0952455706302153 0.850760454545912 miRNAWalker2_validate -0.0556563533318605 0.0213986624593294 hsa-miR-374a-5p EP300 -0.0192159163584709 0.965315201402842 -0.0381739592699031 0.951249053975231 miRNAWalker2_validate;mirMAP -0.0752319290612454 0.0339637722000329 hsa-miR-374b-5p CCND1 -0.0341588728964348 0.947017013085837 0.0138594286077627 0.985644356886489 miRNAWalker2_validate;MirTarget -0.531193112029599 5.3445494840887e-15 hsa-miR-375 FZD8 0.324254910768071 0.784908661939924 -0.078904880304417 0.834803608799275 miRNAWalker2_validate -0.0689614009068602 0.00037087636471027 hsa-miR-375 PRKCA 0.324254910768071 0.784908661939924 -0.227245147154052 0.467261641689546 miRNAWalker2_validate -0.240131861837491 2.29799527522168e-39 23497265 The integrated analysis of miRNA and mRNA expression identified 35 known and novel target genes of miR-200c miR-205 and mir-375 including CFL2 LAMC1 TIMP2 ZEB1 CDH11 PRKCA PTPRJ PTPRM LDHB and SEC23A breast cancer hsa-miR-375 PRKX 0.324254910768071 0.784908661939924 -0.16691261365817 0.713645814762555 miRNAWalker2_validate;miRanda -0.207392873270567 7.07421795114455e-35 hsa-miR-424-5p CCND1 -0.0714822550667202 0.907577243491088 0.0138594286077627 0.985644356886489 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.165346668007668 1.17175782770906e-05 hsa-miR-425-5p PPP2CB -0.179935054542016 0.805737521016457 0.0839352957265156 0.884120786282379 miRNAWalker2_validate -0.1434305833926 3.027811361313e-18 hsa-miR-429 EP300 -0.142589289838583 0.802317907773415 -0.0381739592699031 0.951249053975231 miRNAWalker2_validate;miRanda;miRNATAP -0.0728175718912227 3.56075984974409e-06 hsa-miR-429 MYC -0.142589289838583 0.802317907773415 0.0371115296700548 0.951416673961988 miRNAWalker2_validate -0.108453248703558 4.76591679996824e-05 21684154;21684154;21684154 miR-429 modulates the expression of c-myc in human gastric carcinoma cells;SGC-7901 gastric cancer cells were transfected with miR-429 mimics and endogenous c-myc expression was detected by western blots;miR-429 significantly downregulated endogenous c-myc expression in SGC-7901 cells ;; stomach cancer;stomach cancer;stomach cancer hsa-miR-429 TCF7L1 -0.142589289838583 0.802317907773415 -0.1613283678339 0.721505802735508 miRNAWalker2_validate -0.134496234177534 7.39492362051745e-06 hsa-miR-450a-5p FBXW11 0.010819116379897 0.971621466675537 0.00937498411107818 0.985997496641178 miRNAWalker2_validate -0.0617020617993958 0.000133698413897841 hsa-miR-590-3p PPP2R5A -0.133358268237272 0.535686159072243 0.0837534785515848 0.890977423101542 miRNAWalker2_validate -0.0600357938097387 0.00563114942616679 hsa-miR-652-3p CSNK1A1 -0.12049111975233 0.786404277874184 -0.0165042555609478 0.982452723332151 miRNAWalker2_validate -0.106904286901307 7.62564332600731e-11 hsa-miR-744-5p FRAT1 -0.117721143255717 0.775755712074427 0.0717364474803182 0.782088380245773 miRNAWalker2_validate -0.0778076471439744 0.00597160249648584 hsa-miR-769-5p CREBBP -0.10362464632991 0.793365222563107 -0.121528460671809 0.849036225288355 miRNAWalker2_validate -0.0522468958915988 0.0193949621926048 hsa-miR-9-5p CCND1 0.513826958284847 0.574325590140814 0.0138594286077627 0.985644356886489 miRNAWalker2_validate -0.162121975003827 1.12937727530253e-12 hsa-miR-92a-3p BTRC -0.0230307937945682 0.984317735692711 -0.113796391872094 0.818463431452382 miRNAWalker2_validate -0.218742875572353 1.77336318401607e-14 hsa-miR-92a-3p CCND1 -0.0230307937945682 0.984317735692711 0.0138594286077627 0.985644356886489 miRNAWalker2_validate -0.355039027931141 1.3665845638516e-10 hsa-miR-92a-3p MAPK9 -0.0230307937945682 0.984317735692711 -0.00950322920821378 0.985902275586564 miRNAWalker2_validate -0.159802962706798 1.32672396914361e-13 hsa-miR-92a-3p PPP2R1A -0.0230307937945682 0.984317735692711 0.0981760857696141 0.894638367692319 miRNAWalker2_validate -0.0541156654278205 0.00785264900927655 hsa-miR-92a-3p WNT5A -0.0230307937945682 0.984317735692711 -0.37564066226164 0.355542462686927 miRNAWalker2_validate -0.456191278985706 5.11502285589708e-16 hsa-miR-93-5p CCND1 0.0554251653547535 0.959380932710413 0.0138594286077627 0.985644356886489 miRNAWalker2_validate;MirTarget;miRNATAP -0.160469090487963 0.00197437840989499 25371073 Furthermore miR-93 may downregulate the Wnt/β-catenin pathway which was confirmed by measuring the expression level of the β-catenin axin c-Myc and cyclin-D1 in this pathway colorectal cancer hsa-miR-93-5p JUN 0.0554251653547535 0.959380932710413 -0.108657195258627 0.877583083771737 miRNAWalker2_validate -0.216264935663652 4.08318210776355e-08 hsa-miR-93-5p MAPK9 0.0554251653547535 0.959380932710413 -0.00950322920821378 0.985902275586564 miRNAWalker2_validate;miRNATAP -0.0626717362961684 0.00204360229224494 hsa-miR-93-5p PRKACB 0.0554251653547535 0.959380932710413 -0.0742837105484302 0.886731753016865 miRNAWalker2_validate -0.337877597223658 9.95580809015501e-13 hsa-miR-93-5p SMAD4 0.0554251653547535 0.959380932710413 -0.0337260829637342 0.952673159973339 miRNAWalker2_validate;mirMAP;miRNATAP -0.118636275861089 1.4710971943885e-09 hsa-miR-98-5p FZD10 0.0782917740368987 0.880173437070493 -0.157448402775842 0.382566977418384 miRNAWalker2_validate -0.461667265087064 4.29163451584181e-11 hsa-miR-203a-3p SMAD4 -0.0587428946483168 0.955500869059044 -0.0337260829637342 0.952673159973339 miRTarBase -0.053106206691725 1.95692576866529e-08 hsa-miR-15b-5p AXIN2 0.0382341477298391 0.953925647243518 -0.0138759668242621 0.966117623520896 miRTarBase;MirTarget;miRNATAP -0.249089153159517 2.51640038854339e-11 hsa-miR-107 AXIN2 -0.00374429919903285 0.994322461958742 -0.0138759668242621 0.966117623520896 miRTarBase;MirTarget;PITA;miRanda;miRNATAP -0.313818454372385 2.10386522757559e-09 hsa-let-7a-2-3p NLK -0.339913368059229 0.222872773717896 -0.0075726819422437 0.986090753913933 MirTarget -0.0562551511240885 0.000241730514807963 hsa-let-7d-5p FZD4 -0.176960380407253 0.795858406343421 0.0304707076358319 0.955399406040093 MirTarget;miRNATAP -0.378548770288792 7.31572406282056e-13 hsa-let-7e-5p FZD4 0.0357092208790988 0.968612511131967 0.0304707076358319 0.955399406040093 MirTarget;miRNATAP -0.142834413823916 0.0136912438497173 hsa-let-7g-3p AXIN2 -0.39123398731129 0.399100962252738 -0.0138759668242621 0.966117623520896 MirTarget -0.15927262941163 2.22164738358529e-09 hsa-let-7g-3p FZD4 -0.39123398731129 0.399100962252738 0.0304707076358319 0.955399406040093 MirTarget;miRNATAP -0.181060509538746 5.2893212751556e-10 hsa-miR-1-3p WNT3 0.121677228823826 0.614674337813684 -0.0153912479566303 0.926692523100822 MirTarget -0.0891905066583286 0.00539856572031174 hsa-miR-101-3p NLK -0.140525462772132 0.906382304639665 -0.0075726819422437 0.986090753913933 MirTarget;miRNATAP -0.0748283999471291 0.0140103716529702 hsa-miR-103a-3p FZD3 0.0952235048222612 0.939840715516335 -0.0249834874630155 0.930139178962665 MirTarget -0.217217198769376 1.65600292637449e-05 hsa-miR-103a-3p NFAT5 0.0952235048222612 0.939840715516335 -0.140634566870934 0.80102714017311 MirTarget -0.336653367297422 1.28063362403024e-24 hsa-miR-106a-5p CCND1 -0.142040012764908 0.692192967482747 0.0138594286077627 0.985644356886489 MirTarget;miRNATAP -0.174359830876255 2.65007775906387e-06 hsa-miR-106b-5p FZD3 -0.0853499657102335 0.901700669947609 -0.0249834874630155 0.930139178962665 MirTarget;mirMAP;miRNATAP -0.0948650511986842 0.021058235442605 hsa-miR-106b-5p NFAT5 -0.0853499657102335 0.901700669947609 -0.140634566870934 0.80102714017311 MirTarget;miRNATAP -0.23715765114845 1.20613671461126e-18 hsa-miR-107 FZD3 -0.00374429919903285 0.994322461958742 -0.0249834874630155 0.930139178962665 MirTarget;miRanda -0.179768540730773 0.00061594712979082 hsa-miR-107 NFAT5 -0.00374429919903285 0.994322461958742 -0.140634566870934 0.80102714017311 MirTarget -0.295966190654869 8.65322066760854e-18 hsa-miR-107 BTRC -0.00374429919903285 0.994322461958742 -0.113796391872094 0.818463431452382 MirTarget;miRanda;miRNATAP -0.176399193835294 3.95816507165993e-07 hsa-miR-125b-2-3p PPP2CA -0.19521949049782 0.618072714328679 0.0284217367477391 0.96534362029265 MirTarget -0.0997688568203327 6.31632051255472e-20 hsa-miR-125b-5p CSNK2A1 -0.0598851546678105 0.945288350565791 0.0222385179144631 0.968143761360086 MirTarget;miRNATAP -0.0687927662333148 2.30709647024534e-05 hsa-miR-126-5p WNT3 -0.0509133532389665 0.941546676673956 -0.0153912479566303 0.926692523100822 MirTarget -0.0971027984125306 0.0469184460867598 hsa-miR-128-3p PPP2R1B -0.0716382541209697 0.906783499707385 -0.00522798350256881 0.991408260059311 MirTarget -0.109583188561297 0.000963818534703709 hsa-miR-1296-5p FRAT1 -0.111318271216588 0.672454874789584 0.0717364474803182 0.782088380245773 MirTarget -0.202422777904563 2.39294268910508e-16 hsa-miR-1301-3p NFAT5 -0.0935647712087007 0.781492825390485 -0.140634566870934 0.80102714017311 MirTarget -0.114089558751608 4.42769113606664e-09 hsa-miR-1301-3p SFRP1 -0.0935647712087007 0.781492825390485 -0.472006437969406 0.460625213922239 MirTarget -0.627568666111828 8.02299635565225e-16 hsa-miR-130a-3p SKP1 -0.19782843294836 0.720491845034151 0.11984894684252 0.870895899955478 MirTarget -0.139641825685064 4.17514374271046e-19 hsa-miR-130b-3p SKP1 -0.211426879967744 0.486104856445712 0.11984894684252 0.870895899955478 MirTarget -0.106102178127117 1.72601795720608e-11 hsa-miR-130b-3p WNT2B -0.211426879967744 0.486104856445712 -0.120458000644347 0.404153656056463 MirTarget -0.16709837520953 1.43976112122382e-06 hsa-miR-130b-3p FBXW11 -0.211426879967744 0.486104856445712 0.00937498411107818 0.985997496641178 MirTarget -0.0835497801797836 3.48650254394124e-08 hsa-miR-130b-3p DAAM1 -0.211426879967744 0.486104856445712 -0.0539991515887506 0.906596879539895 MirTarget;miRNATAP -0.119223163450559 9.89442748145749e-05 hsa-miR-132-3p DAAM1 0.0245028522614428 0.964849701708711 -0.0539991515887506 0.906596879539895 MirTarget;miRNATAP -0.0973955804505404 0.0426414850135555 hsa-miR-132-3p PRICKLE2 0.0245028522614428 0.964849701708711 0.0177255412987654 0.969497997086328 MirTarget;miRNATAP -0.13545645775625 0.00901118165664025 hsa-miR-132-3p BTRC 0.0245028522614428 0.964849701708711 -0.113796391872094 0.818463431452382 MirTarget -0.16624989082982 1.42128564671786e-06 hsa-miR-132-3p PPP2R5E 0.0245028522614428 0.964849701708711 -0.08594361639783 0.857732462812563 MirTarget -0.117209424280952 5.86934317627525e-05 hsa-miR-139-5p PPP2CA 0.00543145985495741 0.991591290852214 0.0284217367477391 0.96534362029265 MirTarget;PITA;miRanda -0.0752357615240133 2.77630014146499e-13 hsa-miR-140-3p RHOA -0.0813609197213889 0.923953795876038 0.0333557466121839 0.967744764731311 MirTarget;PITA;miRNATAP -0.0638356714059831 2.22577877353767e-06 hsa-miR-140-3p WNT5A -0.0813609197213889 0.923953795876038 -0.37564066226164 0.355542462686927 MirTarget;miRNATAP -0.114362373598219 0.0313125845610264 hsa-miR-140-3p PPP2R5C -0.0813609197213889 0.923953795876038 -0.0241791959006408 0.968345143230327 MirTarget -0.0584432436380268 3.98011108460491e-05 hsa-miR-140-5p PSEN1 -0.310979285894735 0.512489148244786 -0.0685344526261558 0.908564158711858 MirTarget;miRanda -0.0515684505321634 0.00262570506864299 hsa-miR-140-5p NLK -0.310979285894735 0.512489148244786 -0.0075726819422437 0.986090753913933 MirTarget;PITA;miRanda;miRNATAP -0.139208185186153 3.98951586060413e-08 hsa-miR-141-3p CCND2 -0.179420502124191 0.83354105481228 -0.168931301767903 0.722558871099741 MirTarget;TargetScan -0.300723945575078 8.35441899721039e-47 hsa-miR-141-3p PRKACB -0.179420502124191 0.83354105481228 -0.0742837105484302 0.886731753016865 MirTarget;TargetScan;miRNATAP -0.14986275424127 3.7367241254854e-07 hsa-miR-141-5p WNT5A -0.21874832932521 0.789341690802864 -0.37564066226164 0.355542462686927 MirTarget;miRNATAP -0.0866884657182266 0.0169802422844932 hsa-miR-142-5p NFAT5 -0.35195621065247 0.488286772825655 -0.140634566870934 0.80102714017311 MirTarget;PITA;miRNATAP -0.0615379074254929 0.000766230118699671 hsa-miR-143-3p PSEN1 0.0939643084482285 0.945738813861442 -0.0685344526261558 0.908564158711858 MirTarget -0.063910999167567 2.48297555044168e-05 hsa-miR-143-3p CSNK2A1 0.0939643084482285 0.945738813861442 0.0222385179144631 0.968143761360086 MirTarget -0.102863413291093 1.39184437094928e-08 hsa-miR-145-3p TBL1XR1 0.0290755985159716 0.949161790728202 -0.115313887374555 0.864767739366221 MirTarget -0.0823063145141243 7.47186450159711e-05 hsa-miR-146a-5p CXXC4 -0.362125606043493 0.545323292976414 -0.189634120723988 0.402205830601326 MirTarget -0.177215728802693 0.000129668828770531 hsa-miR-146a-5p WNT3 -0.362125606043493 0.545323292976414 -0.0153912479566303 0.926692523100822 MirTarget -0.201603839063412 1.26011961583069e-07 hsa-miR-146b-5p CXXC4 0.00834882458611474 0.991577009242932 -0.189634120723988 0.402205830601326 MirTarget;miRNATAP -0.402161602310286 2.78295064213365e-12 hsa-miR-146b-5p WNT3 0.00834882458611474 0.991577009242932 -0.0153912479566303 0.926692523100822 MirTarget;PITA;miRanda;miRNATAP -0.19864051897856 3.55693736099291e-05 hsa-miR-148a-3p SKP1 -0.184595009730559 0.892714155682155 0.11984894684252 0.870895899955478 MirTarget -0.0817626785415723 2.03052522852265e-06 hsa-miR-148a-3p PRICKLE2 -0.184595009730559 0.892714155682155 0.0177255412987654 0.969497997086328 MirTarget;miRNATAP -0.136596669407525 0.000140359936538593 hsa-miR-148a-3p WNT10B -0.184595009730559 0.892714155682155 -0.0665077334487325 0.757196276823523 MirTarget -0.225697074269929 2.08337307308921e-05 hsa-miR-148a-5p PPP2R5E -0.200917166615887 0.667057353234933 -0.08594361639783 0.857732462812563 MirTarget -0.0607588296814851 0.00290662979266384 hsa-miR-148a-5p CSNK1A1 -0.200917166615887 0.667057353234933 -0.0165042555609478 0.982452723332151 MirTarget -0.0707788779328241 9.090668422758e-06 hsa-miR-148b-3p PRICKLE2 -0.121415535518017 0.85232232285121 0.0177255412987654 0.969497997086328 MirTarget;miRNATAP -0.368462111806635 1.62423559573341e-16 hsa-miR-148b-3p WNT10B -0.121415535518017 0.85232232285121 -0.0665077334487325 0.757196276823523 MirTarget -0.328579720045847 9.29413365918993e-07 hsa-miR-149-5p FOSL1 0.110896382194027 0.854013616827913 -0.159042614544989 0.469785833001196 MirTarget;miRNATAP -0.217220245133133 1.20539701452285e-10 hsa-miR-150-5p NLK -0.38061861500346 0.649699545321307 -0.0075726819422437 0.986090753913933 MirTarget -0.0795507281791617 6.21281052546583e-10 hsa-miR-152-3p SKP1 -0.0912672611791701 0.896838779751061 0.11984894684252 0.870895899955478 MirTarget -0.0643040290937307 0.00305236087981287 hsa-miR-152-3p NLK -0.0912672611791701 0.896838779751061 -0.0075726819422437 0.986090753913933 MirTarget -0.121964596915363 5.58054397729548e-06 hsa-miR-15a-5p PPP2R1B 0.027476192963463 0.965257307327948 -0.00522798350256881 0.991408260059311 MirTarget -0.195736754254626 1.30304715741401e-08 hsa-miR-15a-5p TBL1XR1 0.027476192963463 0.965257307327948 -0.115313887374555 0.864767739366221 MirTarget -0.0722823431405159 0.0058823811456917 hsa-miR-15a-5p AXIN2 0.027476192963463 0.965257307327948 -0.0138759668242621 0.966117623520896 MirTarget;miRNATAP -0.308482083886854 2.3359131858061e-10 hsa-miR-15a-5p SMAD3 0.027476192963463 0.965257307327948 -0.00805727245311783 0.987902560465751 MirTarget -0.127238885845652 3.99211956272264e-05 hsa-miR-15a-5p NFAT5 0.027476192963463 0.965257307327948 -0.140634566870934 0.80102714017311 MirTarget -0.336948547662713 2.05581015414347e-26 hsa-miR-15a-5p FZD4 0.027476192963463 0.965257307327948 0.0304707076358319 0.955399406040093 MirTarget -0.396430785367124 8.19331587254851e-14 hsa-miR-15a-5p NFATC3 0.027476192963463 0.965257307327948 -0.00280369997980578 0.995287940001814 MirTarget;miRNATAP -0.231009103502432 3.55309483569134e-22 hsa-miR-15b-5p SMAD3 0.0382341477298391 0.953925647243518 -0.00805727245311783 0.987902560465751 MirTarget -0.103829420518863 1.25324379645245e-05 hsa-miR-15b-5p BTRC 0.0382341477298391 0.953925647243518 -0.113796391872094 0.818463431452382 MirTarget;miRNATAP -0.098692070849702 7.49411486561729e-05 hsa-miR-15b-5p NFAT5 0.0382341477298391 0.953925647243518 -0.140634566870934 0.80102714017311 MirTarget -0.0934386743991916 0.000191005847665648 hsa-miR-15b-5p FZD4 0.0382341477298391 0.953925647243518 0.0304707076358319 0.955399406040093 MirTarget -0.335171646720997 1.57029090717913e-16 hsa-miR-16-1-3p FBXW11 -0.172993537212073 0.391863504419512 0.00937498411107818 0.985997496641178 MirTarget -0.0625194762536327 0.000459242227403029 hsa-miR-16-1-3p ROCK1 -0.172993537212073 0.391863504419512 -0.172548975888922 0.760861741105756 MirTarget -0.0869540296169407 0.000855200324506474 hsa-miR-16-1-3p SFRP1 -0.172993537212073 0.391863504419512 -0.472006437969406 0.460625213922239 MirTarget -0.711103027959144 8.81693153322732e-12 hsa-miR-16-2-3p WNT5A -0.107555719075227 0.702302679752719 -0.37564066226164 0.355542462686927 MirTarget;mirMAP -0.339885804294178 3.30301649240528e-14 hsa-miR-16-5p FZD4 -0.131938295863899 0.869419037928521 0.0304707076358319 0.955399406040093 MirTarget -0.244461027478749 6.1956298490801e-07 hsa-miR-17-3p PPP2CA -0.00462206849027691 0.994608252674318 0.0284217367477391 0.96534362029265 MirTarget -0.133330530645377 1.5958296816568e-20 hsa-miR-17-3p FZD4 -0.00462206849027691 0.994608252674318 0.0304707076358319 0.955399406040093 MirTarget -0.488528178794328 1.80113152001825e-35 hsa-miR-17-3p PPP3CA -0.00462206849027691 0.994608252674318 -0.078895894384611 0.886413963353503 MirTarget -0.124078923715287 5.08318296663462e-06 hsa-miR-181a-5p PPP2R5E 0.0637093750406734 0.945876131429707 -0.08594361639783 0.857732462812563 MirTarget;mirMAP -0.172705968640064 4.32215395940648e-12 hsa-miR-181a-5p PPP3R1 0.0637093750406734 0.945876131429707 -0.0271826487262787 0.962679518571233 MirTarget;miRNATAP -0.066533655540662 0.000665578435861528 hsa-miR-181a-5p NFAT5 0.0637093750406734 0.945876131429707 -0.140634566870934 0.80102714017311 MirTarget;miRNATAP -0.187828472037995 2.67099255156267e-10 hsa-miR-181a-5p MAP3K7 0.0637093750406734 0.945876131429707 -0.104962611573905 0.825259838393628 MirTarget -0.054532207835829 0.0160434336432652 hsa-miR-181b-5p PPP2R5E 0.0375130667115933 0.959555096276237 -0.08594361639783 0.857732462812563 MirTarget;mirMAP -0.122508311764402 6.82476700676191e-09 hsa-miR-181b-5p NFAT5 0.0375130667115933 0.959555096276237 -0.140634566870934 0.80102714017311 MirTarget;miRNATAP -0.21216357383761 1.4174363007063e-17 hsa-miR-181c-5p PPP2R5E -0.18121298802215 0.718350072627076 -0.08594361639783 0.857732462812563 MirTarget;mirMAP -0.122046895343518 1.35193024529625e-08 hsa-miR-181c-5p PPP3R1 -0.18121298802215 0.718350072627076 -0.0271826487262787 0.962679518571233 MirTarget;miRNATAP -0.125950184238424 2.66954355100233e-14 hsa-miR-181c-5p NFAT5 -0.18121298802215 0.718350072627076 -0.140634566870934 0.80102714017311 MirTarget;miRNATAP -0.065507059315267 0.0109933920727873 hsa-miR-181c-5p MAP3K7 -0.18121298802215 0.718350072627076 -0.104962611573905 0.825259838393628 MirTarget -0.0719828194627102 0.000204064582876833 hsa-miR-181d-5p PPP2R5E -0.116844052208921 0.774221578291478 -0.08594361639783 0.857732462812563 MirTarget -0.0940312381428415 6.91615878244968e-07 hsa-miR-181d-5p PPP3R1 -0.116844052208921 0.774221578291478 -0.0271826487262787 0.962679518571233 MirTarget -0.0932828411439749 1.78868200053676e-10 hsa-miR-181d-5p NFAT5 -0.116844052208921 0.774221578291478 -0.140634566870934 0.80102714017311 MirTarget -0.0724300467410793 0.00137321273385777 hsa-miR-181d-5p MAP3K7 -0.116844052208921 0.774221578291478 -0.104962611573905 0.825259838393628 MirTarget -0.0592938070299311 0.000508197865718437 hsa-miR-182-5p PRICKLE2 -0.101509746042318 0.939206381321837 0.0177255412987654 0.969497997086328 MirTarget -0.183980281487538 1.18712295456704e-09 hsa-miR-182-5p ROCK1 -0.101509746042318 0.939206381321837 -0.172548975888922 0.760861741105756 MirTarget -0.0792467059531576 0.000107199608429092 hsa-miR-182-5p APC -0.101509746042318 0.939206381321837 -0.0723635628413355 0.883189867616246 MirTarget -0.0754793692814454 0.00023735688656357 hsa-miR-183-5p PPP2CB -0.0285894962233133 0.980944848059819 0.0839352957265156 0.884120786282379 MirTarget;miRNATAP -0.0816694898012429 2.48553389599593e-09 hsa-miR-183-5p TCF7L2 -0.0285894962233133 0.980944848059819 -0.151922190442888 0.739870566881007 MirTarget;miRNATAP -0.256342247617245 6.25752369970953e-30 hsa-miR-185-3p NFATC4 -0.0609325092037492 0.780830371804221 0.118767632463774 0.80554796605913 MirTarget -0.221463917308086 4.38182247561287e-11 hsa-miR-185-3p TCF7 -0.0609325092037492 0.780830371804221 -0.190752137435303 0.611949137914896 MirTarget;miRNATAP -0.0909737352420878 0.00890960015275978 hsa-miR-185-5p CCND2 0.0659414824247602 0.896134370932431 -0.168931301767903 0.722558871099741 MirTarget;miRNATAP -0.252091965164496 1.07493887045353e-07 hsa-miR-185-5p VANGL2 0.0659414824247602 0.896134370932431 -0.491521821831935 0.31936517526481 MirTarget -0.18480243983042 0.0304060015816039 hsa-miR-185-5p SMAD3 0.0659414824247602 0.896134370932431 -0.00805727245311783 0.987902560465751 MirTarget -0.139641114876277 4.17733017511663e-05 hsa-miR-185-5p NFATC2 0.0659414824247602 0.896134370932431 -0.38368313501719 0.1310673127204 MirTarget -0.480154397877674 9.64194904728437e-08 hsa-miR-185-5p FZD4 0.0659414824247602 0.896134370932431 0.0304707076358319 0.955399406040093 MirTarget -0.32822571943949 2.4240703164448e-08 hsa-miR-185-5p NFATC3 0.0659414824247602 0.896134370932431 -0.00280369997980578 0.995287940001814 MirTarget;miRNATAP -0.124879744848212 3.18788249333561e-06 hsa-miR-186-5p PRICKLE2 -0.14779866926096 0.840248407765158 0.0177255412987654 0.969497997086328 MirTarget -0.315192987077069 1.89815838419289e-12 hsa-miR-18a-5p NFAT5 -0.060215066151506 0.836155187457355 -0.140634566870934 0.80102714017311 MirTarget;miRNATAP -0.0634250357094723 0.0001883938804432 hsa-miR-18a-5p PRICKLE2 -0.060215066151506 0.836155187457355 0.0177255412987654 0.969497997086328 MirTarget -0.387730469036141 3.85619154280423e-61 hsa-miR-191-5p CCND2 -0.264247937125955 0.760894795645613 -0.168931301767903 0.722558871099741 MirTarget -0.190841372088135 4.05600831845751e-09 23505378 Furthermore enforced expression of the miR-191/425 cluster in aggressive breast cancer cells altered global gene expression profiles and enabled us to identify important tumor promoting genes including SATB1 CCND2 and FSCN1 as targets of miR-191 and miR-425 invasion; breast cancer hsa-miR-193a-3p BTRC -0.0143163678163178 0.969244019090322 -0.113796391872094 0.818463431452382 MirTarget;miRanda -0.0726547957898539 0.00646842323738674 hsa-miR-194-5p PPP3CA -0.0985657553098873 0.88041455080541 -0.078895894384611 0.886413963353503 MirTarget -0.132376274530416 0.000303144003211118 hsa-miR-194-5p FZD6 -0.0985657553098873 0.88041455080541 -0.169694244565214 0.734859272253398 MirTarget -0.1574113672057 0.003131819177647 hsa-miR-195-5p TBL1XR1 -0.00971531160236339 0.98418421453416 -0.115313887374555 0.864767739366221 MirTarget -0.0945188569221093 1.73541158701183e-06 hsa-miR-197-3p NLK -0.16253774958271 0.828233346204688 -0.0075726819422437 0.986090753913933 MirTarget;miRNATAP -0.0756978210930982 0.000982784041662648 hsa-miR-1976 SMAD3 -0.190354496295963 0.520771411809134 -0.00805727245311783 0.987902560465751 MirTarget -0.121630671332983 6.52049342337766e-05 hsa-miR-199a-3p NLK -0.115440021652793 0.912942630248289 -0.0075726819422437 0.986090753913933 MirTarget;PITA;miRNATAP -0.0804263208809472 0.000294140442438701 hsa-miR-199a-5p NLK -0.0114843373708311 0.9900489817393 -0.0075726819422437 0.986090753913933 MirTarget;PITA;miRanda;miRNATAP -0.0984384958124425 5.51382816233245e-06 hsa-miR-199a-5p FZD6 -0.0114843373708311 0.9900489817393 -0.169694244565214 0.734859272253398 MirTarget;miRanda;miRNATAP -0.0910545999999751 0.0194128973779915 hsa-miR-199b-3p NLK -0.117157552965615 0.911609413213755 -0.0075726819422437 0.986090753913933 MirTarget;PITA;miRNATAP -0.0794435550896334 0.000334235907978254 hsa-miR-199b-5p NLK -0.0420618710265854 0.953083764782006 -0.0075726819422437 0.986090753913933 MirTarget;PITA;miRanda;miRNATAP -0.130208304038465 2.10468258720444e-11 hsa-miR-19a-3p CCND2 -0.00951638786771092 0.980991306004163 -0.168931301767903 0.722558871099741 MirTarget;miRNATAP -0.185131062383478 6.94387115240903e-13 hsa-miR-19a-3p PRICKLE2 -0.00951638786771092 0.980991306004163 0.0177255412987654 0.969497997086328 MirTarget;miRNATAP -0.402369518872812 5.04349600060003e-48 hsa-miR-19a-3p PRKACB -0.00951638786771092 0.980991306004163 -0.0742837105484302 0.886731753016865 MirTarget;miRNATAP -0.144307019920445 3.41593280940585e-05 hsa-miR-19a-3p FBXW11 -0.00951638786771092 0.980991306004163 0.00937498411107818 0.985997496641178 MirTarget -0.0929782801423033 2.98169547317761e-12 hsa-miR-19b-1-5p CXXC4 -0.126966953724701 0.619571308879527 -0.189634120723988 0.402205830601326 MirTarget -0.218495308109611 4.52597594786824e-05 hsa-miR-19b-3p PRICKLE2 -0.0314903804749491 0.95913844863355 0.0177255412987654 0.969497997086328 MirTarget;miRNATAP -0.400025342580155 8.2019109465105e-31 hsa-miR-19b-3p FBXW11 -0.0314903804749491 0.95913844863355 0.00937498411107818 0.985997496641178 MirTarget -0.086319897484431 1.51656429104961e-07 hsa-miR-200a-3p CCND2 -0.192839143060886 0.77994979695622 -0.168931301767903 0.722558871099741 MirTarget -0.261226562912324 4.31939405604759e-36 hsa-miR-200a-3p PRKACB -0.192839143060886 0.77994979695622 -0.0742837105484302 0.886731753016865 MirTarget;miRNATAP -0.0995415556173883 0.000611951485595998 hsa-miR-200b-3p PPP2R1B -0.109983892590611 0.891357972128093 -0.00522798350256881 0.991408260059311 MirTarget -0.190114683335312 5.20726875191601e-24 hsa-miR-200b-3p PRKACB -0.109983892590611 0.891357972128093 -0.0742837105484302 0.886731753016865 MirTarget;TargetScan -0.128358992363134 6.97422500356901e-05 hsa-miR-200b-3p PRKCB -0.109983892590611 0.891357972128093 -0.253273703233256 0.375512080029025 MirTarget -0.185811618752792 2.61023291805883e-06 hsa-miR-200b-3p JUN -0.109983892590611 0.891357972128093 -0.108657195258627 0.877583083771737 MirTarget;TargetScan -0.16460620647419 5.28647088864828e-10 hsa-miR-200b-3p FBXW11 -0.109983892590611 0.891357972128093 0.00937498411107818 0.985997496641178 MirTarget;TargetScan -0.0775341009290198 3.741753384511e-10 hsa-miR-200c-3p PPP2R1B -0.0449560636499466 0.969433069399071 -0.00522798350256881 0.991408260059311 MirTarget -0.226923946553815 2.68646974148231e-28 hsa-miR-200c-3p PRKACB -0.0449560636499466 0.969433069399071 -0.0742837105484302 0.886731753016865 MirTarget;miRNATAP -0.165596646495394 2.94921644943646e-06 hsa-miR-200c-3p PRKCB -0.0449560636499466 0.969433069399071 -0.253273703233256 0.375512080029025 MirTarget;miRNATAP -0.190171510726694 1.24294313881003e-05 hsa-miR-200c-3p JUN -0.0449560636499466 0.969433069399071 -0.108657195258627 0.877583083771737 MirTarget -0.273188681953389 1.78966606345752e-21 hsa-miR-200c-3p FBXW11 -0.0449560636499466 0.969433069399071 0.00937498411107818 0.985997496641178 MirTarget;miRNATAP -0.07817640171588 9.85391226368126e-09 hsa-miR-203a-3p PRICKLE2 -0.0587428946483168 0.955500869059044 0.0177255412987654 0.969497997086328 MirTarget -0.0904655750328093 2.80369275676329e-06 hsa-miR-20a-3p SMAD3 -0.267112043185936 0.342386318550293 -0.00805727245311783 0.987902560465751 MirTarget -0.0519894042578679 0.00251395004716515 hsa-miR-20a-5p NFAT5 0.0648697217907399 0.924634007033878 -0.140634566870934 0.80102714017311 MirTarget;miRNATAP -0.0877257434640789 8.89327508912792e-05 hsa-miR-20b-5p CCND1 -0.275771697228234 0.506979861341138 0.0138594286077627 0.985644356886489 MirTarget;miRNATAP -0.0991786139361312 0.000434868046399598 hsa-miR-20b-5p NFAT5 -0.275771697228234 0.506979861341138 -0.140634566870934 0.80102714017311 MirTarget;miRNATAP -0.0652708167918447 8.41303391266267e-06 hsa-miR-21-3p CREBBP -0.103229815917794 0.915406989389524 -0.121528460671809 0.849036225288355 MirTarget -0.0531489438597555 0.000787564088741477 hsa-miR-21-3p NFAT5 -0.103229815917794 0.915406989389524 -0.140634566870934 0.80102714017311 MirTarget -0.182888478641974 1.86723394339074e-16 hsa-miR-212-3p DAAM1 0.0651691163056072 0.740903353495934 -0.0539991515887506 0.906596879539895 MirTarget;miRNATAP -0.0644798821581252 0.0485235027596261 hsa-miR-212-3p PRICKLE2 0.0651691163056072 0.740903353495934 0.0177255412987654 0.969497997086328 MirTarget;miRNATAP -0.180712852119462 2.58202184300501e-07 hsa-miR-212-3p BTRC 0.0651691163056072 0.740903353495934 -0.113796391872094 0.818463431452382 MirTarget -0.173369799058415 8.47662747538148e-14 hsa-miR-214-3p DVL1 -0.110449829460212 0.670567263185672 -0.0106489854425629 0.983281417437041 MirTarget -0.0946327248890004 0.000120922439782448 hsa-miR-214-3p BTRC -0.110449829460212 0.670567263185672 -0.113796391872094 0.818463431452382 MirTarget -0.0949712665118444 4.65448265307247e-06 hsa-miR-214-3p WNT3 -0.110449829460212 0.670567263185672 -0.0153912479566303 0.926692523100822 MirTarget -0.217458243957451 4.77314673966333e-08 hsa-miR-214-5p CCND1 -0.143468551850718 0.734457173217684 0.0138594286077627 0.985644356886489 MirTarget -0.114200722915032 0.0138067660725528 hsa-miR-217 PPP2R5E -0.0872981480242543 0.809509315744678 -0.08594361639783 0.857732462812563 MirTarget -0.0564533238873277 0.000320378450123426 hsa-miR-218-5p PPP2R5A -0.0827242549860268 0.862446853499361 0.0837534785515848 0.890977423101542 MirTarget;miRNATAP -0.093741696234504 0.000238945823293693 hsa-miR-221-3p NLK -0.0578227721969284 0.924067621219326 -0.0075726819422437 0.986090753913933 MirTarget;miRNATAP -0.160004395790496 4.50992101797211e-14 hsa-miR-221-3p CHD8 -0.0578227721969284 0.924067621219326 -0.0178510158573202 0.976383552659853 MirTarget;miRNATAP -0.147913788096852 9.94945179288004e-25 hsa-miR-222-3p SKP1 -0.0901542670760289 0.851836230793884 0.11984894684252 0.870895899955478 MirTarget -0.10501825880122 4.51166430229641e-11 hsa-miR-222-3p NLK -0.0901542670760289 0.851836230793884 -0.0075726819422437 0.986090753913933 MirTarget;miRNATAP -0.0884166612196756 9.19007611632419e-06 hsa-miR-222-3p CHD8 -0.0901542670760289 0.851836230793884 -0.0178510158573202 0.976383552659853 MirTarget;miRNATAP -0.0598412259743293 1.32675721205839e-05 hsa-miR-222-5p NLK -0.42274874322057 0.0487796396911282 -0.0075726819422437 0.986090753913933 MirTarget -0.0745464785200546 5.14257888345386e-05 hsa-miR-223-3p CXXC4 -0.25971106178338 0.669659245147467 -0.189634120723988 0.402205830601326 MirTarget -0.339412266927715 5.92753918193085e-13 hsa-miR-224-5p CXXC4 -0.101100511980041 0.824356781792172 -0.189634120723988 0.402205830601326 MirTarget -0.181942353850854 3.60612131804488e-12 hsa-miR-224-5p BTRC -0.101100511980041 0.824356781792172 -0.113796391872094 0.818463431452382 MirTarget -0.132498017840424 7.27857382043359e-34 hsa-miR-2355-5p NFATC4 -0.0815180829196089 0.870082450607981 0.118767632463774 0.80554796605913 MirTarget -0.314673921460914 7.76236682155888e-11 hsa-miR-2355-5p CHD8 -0.0815180829196089 0.870082450607981 -0.0178510158573202 0.976383552659853 MirTarget;miRNATAP -0.0554882835015905 0.00280668657941108 hsa-miR-24-3p CAMK2B -0.156339520113363 0.865374272536865 0.141283778852512 0.60471522191955 MirTarget -0.668590574540919 9.25330039258928e-14 hsa-miR-25-3p NLK 0.0550592306329012 0.962829613775088 -0.0075726819422437 0.986090753913933 MirTarget;miRNATAP -0.106492227212925 0.0017026454555609 hsa-miR-25-3p CAMK2A 0.0550592306329012 0.962829613775088 -0.202058295390148 0.395922649310232 MirTarget -0.21042761959986 0.00657433659879039 hsa-miR-26a-5p PPP3R1 -0.0558466394626773 0.953979749143751 -0.0271826487262787 0.962679518571233 MirTarget;miRNATAP -0.15120972679612 1.94023722332139e-09 hsa-miR-27a-3p PRICKLE2 -0.0713791016390708 0.936296470694396 0.0177255412987654 0.969497997086328 MirTarget;miRNATAP -0.278229845269387 1.14515707500582e-08 hsa-miR-27a-3p SMAD4 -0.0713791016390708 0.936296470694396 -0.0337260829637342 0.952673159973339 MirTarget -0.107318887613883 7.95509636261065e-06 hsa-miR-27a-3p NFAT5 -0.0713791016390708 0.936296470694396 -0.140634566870934 0.80102714017311 MirTarget -0.0858019741155887 0.00922695344494952 hsa-miR-27b-3p SMAD4 -0.113933322553999 0.889976675583125 -0.0337260829637342 0.952673159973339 MirTarget -0.0711570705796461 0.00146964697834738 hsa-miR-29a-3p DAAM1 -0.173904473376583 0.873886834369773 -0.0539991515887506 0.906596879539895 MirTarget;miRNATAP -0.19764404076712 3.31620000413814e-06 hsa-miR-29a-5p AXIN2 -0.242897712652954 0.339681975959217 -0.0138759668242621 0.966117623520896 MirTarget -0.206530050833047 3.89834897393732e-08 hsa-miR-29b-3p CCND2 -0.147629200668355 0.855068431567557 -0.168931301767903 0.722558871099741 MirTarget;miRNATAP -0.166630108966211 2.5453033344596e-06 hsa-miR-29b-3p PRICKLE2 -0.147629200668355 0.855068431567557 0.0177255412987654 0.969497997086328 MirTarget;miRNATAP -0.230464863795446 6.02712611151921e-09 hsa-miR-29b-3p DAAM1 -0.147629200668355 0.855068431567557 -0.0539991515887506 0.906596879539895 MirTarget;miRNATAP -0.149791302355507 4.83700986797815e-05 hsa-miR-29b-3p NFAT5 -0.147629200668355 0.855068431567557 -0.140634566870934 0.80102714017311 MirTarget;miRNATAP -0.0600778361020768 0.0250544677571084 hsa-miR-29c-3p CTNNBIP1 -0.0526710652467877 0.956320854458284 -0.0617522470279912 0.902562563271752 MirTarget;miRNATAP -0.06769962753461 0.00221403832197531 hsa-miR-29c-3p DAAM1 -0.0526710652467877 0.956320854458284 -0.0539991515887506 0.906596879539895 MirTarget;miRNATAP -0.152602454746229 2.18628177659896e-05 hsa-miR-29c-3p NFAT5 -0.0526710652467877 0.956320854458284 -0.140634566870934 0.80102714017311 MirTarget;miRNATAP -0.0867649420254765 0.000891790355745109 hsa-miR-29c-3p NFATC3 -0.0526710652467877 0.956320854458284 -0.00280369997980578 0.995287940001814 MirTarget;miRNATAP -0.133798476713389 4.59205597740966e-12 hsa-miR-301a-3p WNT2B -0.0522829902990942 0.861546852981366 -0.120458000644347 0.404153656056463 MirTarget -0.104564831857354 0.000130211401798741 hsa-miR-3065-3p CCND2 0.22426467087409 0.627407590125411 -0.168931301767903 0.722558871099741 MirTarget;miRNATAP -0.215305118861858 1.68654607913855e-26 hsa-miR-3065-3p ROCK1 0.22426467087409 0.627407590125411 -0.172548975888922 0.760861741105756 MirTarget -0.0909657729180416 5.53891405765653e-09 hsa-miR-3065-3p DAAM1 0.22426467087409 0.627407590125411 -0.0539991515887506 0.906596879539895 MirTarget;miRNATAP -0.0946169510148288 1.16956225995122e-05 hsa-miR-3065-3p NFAT5 0.22426467087409 0.627407590125411 -0.140634566870934 0.80102714017311 MirTarget;miRNATAP -0.0807290368189317 2.33490159647911e-07 hsa-miR-3065-3p FZD5 0.22426467087409 0.627407590125411 -0.186395173219289 0.518902590417545 MirTarget;miRNATAP -0.0999065511321767 2.06972488256963e-06 hsa-miR-3065-3p NFATC3 0.22426467087409 0.627407590125411 -0.00280369997980578 0.995287940001814 MirTarget;miRNATAP -0.0622663119567803 9.88393368545999e-08 hsa-miR-30a-3p DVL3 -0.361790747715233 0.766608518431902 0.00975763465514845 0.987406911304736 MirTarget -0.062991956042649 3.07960196233484e-09 hsa-miR-30a-3p CACYBP -0.361790747715233 0.766608518431902 0.135598682500361 0.816402229143505 MirTarget -0.119257746654091 3.45819271489493e-13 hsa-miR-30a-3p CAMK2G -0.361790747715233 0.766608518431902 0.119349300317351 0.7992742190937 MirTarget -0.0630455071295042 2.27198637181243e-07 hsa-miR-30a-5p NFATC3 -0.315304933842571 0.81611555406281 -0.00280369997980578 0.995287940001814 MirTarget;miRNATAP -0.0950541756434285 4.06289420424752e-11 hsa-miR-30b-3p WNT7B -0.0548896605999709 0.756378945374427 0.203059513313665 0.583576542147028 MirTarget;mirMAP -0.199927265231065 0.000916083804937799 hsa-miR-30b-3p DVL1 -0.0548896605999709 0.756378945374427 -0.0106489854425629 0.983281417437041 MirTarget -0.115579437179508 2.3800207966178e-05 hsa-miR-30b-5p NFATC2 -0.126278303055191 0.871574517121767 -0.38368313501719 0.1310673127204 MirTarget;mirMAP -0.144039089526949 0.0321201787208961 hsa-miR-30c-5p NFATC2 -0.268052278300344 0.753220585849573 -0.38368313501719 0.1310673127204 MirTarget;mirMAP -0.18024743499037 0.0155205593365833 hsa-miR-30d-3p PPP2R5E 0.010689376681901 0.963707546423024 -0.08594361639783 0.857732462812563 MirTarget -0.053337760238338 0.0337386709910924 hsa-miR-30e-3p DVL3 -0.159454066602024 0.887830180332455 0.00975763465514845 0.987406911304736 MirTarget -0.0619334449823238 0.00616926906904383 hsa-miR-30e-3p CACYBP -0.159454066602024 0.887830180332455 0.135598682500361 0.816402229143505 MirTarget -0.156128522151445 7.85773396828642e-06 hsa-miR-30e-5p CSNK1A1 -0.183864098532103 0.86939509445488 -0.0165042555609478 0.982452723332151 MirTarget -0.118629602890873 4.59975508016632e-07 hsa-miR-3127-5p NFATC1 0.0182394265390076 0.945945803678987 -0.185646077795344 0.648360846073301 MirTarget -0.189661265640464 2.21630997061407e-12 hsa-miR-3127-5p FZD4 0.0182394265390076 0.945945803678987 0.0304707076358319 0.955399406040093 MirTarget -0.353612933288253 8.25127810305334e-22 hsa-miR-320a TBL1XR1 0.0425274543382255 0.958191670788918 -0.115313887374555 0.864767739366221 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.0592686755668503 0.0244190805635998 hsa-miR-320b NFATC2 -0.0203395214664157 0.930562048282019 -0.38368313501719 0.1310673127204 MirTarget -0.160231542240436 0.00642139736942507 hsa-miR-326 WNT7B -0.134657725127161 0.690379143543161 0.203059513313665 0.583576542147028 MirTarget;miRanda -0.161789035877396 9.64577721935033e-05 hsa-miR-330-3p CTNNB1 -0.00366157141494194 0.98416704678615 -0.0805864772545046 0.91992258189981 MirTarget;PITA;miRNATAP -0.0593613878475871 0.00148238261309731 hsa-miR-330-3p PRICKLE2 -0.00366157141494194 0.98416704678615 0.0177255412987654 0.969497997086328 MirTarget -0.191111976333898 1.16789091807142e-07 hsa-miR-331-3p CAMK2A -0.235461895487326 0.594749794653888 -0.202058295390148 0.395922649310232 MirTarget -0.108046315570154 0.0105695968923695 hsa-miR-331-3p TCF7 -0.235461895487326 0.594749794653888 -0.190752137435303 0.611949137914896 MirTarget;miRNATAP -0.153308578278305 7.71083941170175e-06 hsa-miR-335-3p TBL1XR1 0.248840023734261 0.661533599343062 -0.115313887374555 0.864767739366221 MirTarget -0.0594404716306062 3.04795439199827e-05 hsa-miR-335-3p FZD3 0.248840023734261 0.661533599343062 -0.0249834874630155 0.930139178962665 MirTarget;mirMAP -0.113655440180937 1.86044682903159e-05 hsa-miR-335-3p PSEN1 0.248840023734261 0.661533599343062 -0.0685344526261558 0.908564158711858 MirTarget -0.0609665799861247 7.8625064714253e-09 hsa-miR-335-3p WNT3 0.248840023734261 0.661533599343062 -0.0153912479566303 0.926692523100822 MirTarget;mirMAP -0.0689358594507769 0.0436061568796076 hsa-miR-337-3p FRAT2 -0.261670200477266 0.586287331335225 -0.0156891928833645 0.96774417787488 MirTarget;PITA -0.167553471806894 1.26273673886636e-24 hsa-miR-33a-5p PRICKLE2 -0.215117012664838 0.532123464324836 0.0177255412987654 0.969497997086328 MirTarget -0.202816748660763 1.08415799126293e-20 hsa-miR-340-5p TBL1X 0.0820090452273905 0.816484190854532 0.060219580834767 0.90746646150957 MirTarget;mirMAP -0.0549166814373484 0.0435456222267192 hsa-miR-340-5p SMAD2 0.0820090452273905 0.816484190854532 -0.0519399062136339 0.930776806456225 MirTarget -0.145840275032375 8.51041709723394e-21 hsa-miR-340-5p NFAT5 0.0820090452273905 0.816484190854532 -0.140634566870934 0.80102714017311 MirTarget -0.253446045615689 2.48815325036697e-22 hsa-miR-340-5p PPP3CB 0.0820090452273905 0.816484190854532 0.0212980346837259 0.969289216388387 MirTarget -0.156446625862705 8.32036945224755e-19 hsa-miR-340-5p NFATC3 0.0820090452273905 0.816484190854532 -0.00280369997980578 0.995287940001814 MirTarget -0.153252771292197 7.73680776852044e-15 hsa-miR-34c-5p TBL1XR1 0.0263265725823381 0.923214932412527 -0.115313887374555 0.864767739366221 MirTarget;PITA;miRanda;miRNATAP -0.0930790423043879 1.67140059820541e-09 hsa-miR-3607-3p SFRP4 -0.410705558355355 0.442005238257379 -0.0657313828955362 0.911276471082622 MirTarget -0.118981576120521 0.000643377135339091 hsa-miR-361-3p BTRC -0.0127254134873924 0.984476698818773 -0.113796391872094 0.818463431452382 MirTarget;PITA;miRNATAP -0.232101959717311 2.15887515093051e-09 hsa-miR-361-3p FZD4 -0.0127254134873924 0.984476698818773 0.0304707076358319 0.955399406040093 MirTarget -0.210274672274026 0.00114713669929094 hsa-miR-361-3p WNT2 -0.0127254134873924 0.984476698818773 -0.0704278884095242 0.817871130365495 MirTarget -0.266339316841169 0.00199408748413513 hsa-miR-361-3p PPP3CA -0.0127254134873924 0.984476698818773 -0.078895894384611 0.886413963353503 MirTarget;PITA;miRNATAP -0.0983817923500186 0.0225060073653217 hsa-miR-361-5p SMAD2 0.0775639231585332 0.909963521897996 -0.0519399062136339 0.930776806456225 MirTarget -0.168440579811925 1.40285064429544e-08 hsa-miR-361-5p NFAT5 0.0775639231585332 0.909963521897996 -0.140634566870934 0.80102714017311 MirTarget;PITA;mirMAP;miRNATAP -0.133459394718286 0.00775411722566547 hsa-miR-361-5p RHOA 0.0775639231585332 0.909963521897996 0.0333557466121839 0.967744764731311 MirTarget;PITA;miRanda -0.0936136832858473 0.000194241936648477 hsa-miR-361-5p PRICKLE2 0.0775639231585332 0.909963521897996 0.0177255412987654 0.969497997086328 MirTarget;PITA;miRanda;miRNATAP -0.423190675531575 1.14669419541242e-08 hsa-miR-369-3p EP300 -0.0734607425694875 0.755351791463265 -0.0381739592699031 0.951249053975231 MirTarget;PITA;miRNATAP -0.0931013138842514 4.21889936505424e-05 hsa-miR-369-3p FZD6 -0.0734607425694875 0.755351791463265 -0.169694244565214 0.734859272253398 MirTarget -0.0777391076331593 0.0381873747609089 hsa-miR-369-3p FZD5 -0.0734607425694875 0.755351791463265 -0.186395173219289 0.518902590417545 MirTarget;PITA;miRNATAP -0.0833590761814999 0.00849384697938421 hsa-miR-374a-3p RHOA -0.0781632437076389 0.926379383884834 0.0333557466121839 0.967744764731311 MirTarget;miRNATAP -0.0748933035031109 4.58606389597479e-05 hsa-miR-374a-3p PRICKLE2 -0.0781632437076389 0.926379383884834 0.0177255412987654 0.969497997086328 MirTarget;miRNATAP -0.294917743521684 5.68270721710634e-08 hsa-miR-374a-3p WNT3 -0.0781632437076389 0.926379383884834 -0.0153912479566303 0.926692523100822 MirTarget -0.289753487107474 3.61014430173007e-05 hsa-miR-374a-3p PPP2R5E -0.0781632437076389 0.926379383884834 -0.08594361639783 0.857732462812563 MirTarget -0.108150800102799 0.000444740858970142 hsa-miR-374a-5p CCND1 -0.0192159163584709 0.965315201402842 0.0138594286077627 0.985644356886489 MirTarget -0.556352001430099 7.67413515717595e-16 hsa-miR-374a-5p SMAD2 -0.0192159163584709 0.965315201402842 -0.0519399062136339 0.930776806456225 MirTarget -0.0809165767134829 0.000203630233483825 hsa-miR-374a-5p WNT3 -0.0192159163584709 0.965315201402842 -0.0153912479566303 0.926692523100822 MirTarget -0.450647176110379 8.40472532505734e-11 hsa-miR-374b-5p WNT5A -0.0341588728964348 0.947017013085837 -0.37564066226164 0.355542462686927 MirTarget;miRNATAP -0.20398183143879 0.00391173355873326 hsa-miR-374b-5p WNT3 -0.0341588728964348 0.947017013085837 -0.0153912479566303 0.926692523100822 MirTarget -0.339662315482385 7.32586953128491e-07 hsa-miR-376c-3p PPP2R5A -0.207862770329174 0.336782853961576 0.0837534785515848 0.890977423101542 MirTarget -0.0701937323713633 0.000110876718693328 hsa-miR-376c-3p WNT3 -0.207862770329174 0.336782853961576 -0.0153912479566303 0.926692523100822 MirTarget -0.209776014145028 2.6988219390376e-08 hsa-miR-381-3p NLK -0.0215856799485721 0.961260144775191 -0.0075726819422437 0.986090753913933 MirTarget -0.176789380063327 1.23463667918594e-19 hsa-miR-381-3p PPP2R5E -0.0215856799485721 0.961260144775191 -0.08594361639783 0.857732462812563 MirTarget;mirMAP -0.104778657482713 2.09043362809501e-08 hsa-miR-3913-5p SMAD2 -0.0522230839821796 0.748170987254748 -0.0519399062136339 0.930776806456225 MirTarget;miRNATAP -0.0770824324478119 1.2863805986301e-05 hsa-miR-424-5p BTRC -0.0714822550667202 0.907577243491088 -0.113796391872094 0.818463431452382 MirTarget;miRNATAP -0.05655165326153 0.00396153414529555 hsa-miR-424-5p FZD4 -0.0714822550667202 0.907577243491088 0.0304707076358319 0.955399406040093 MirTarget -0.0976442486872709 0.0026455708845241 hsa-miR-429 PPP2R1B -0.142589289838583 0.802317907773415 -0.00522798350256881 0.991408260059311 MirTarget;miRanda;miRNATAP -0.148415458438853 1.78268855237664e-18 hsa-miR-429 PRKACB -0.142589289838583 0.802317907773415 -0.0742837105484302 0.886731753016865 MirTarget;PITA;miRanda;miRNATAP -0.0987523385236987 0.000620715443624304 hsa-miR-429 PRKCB -0.142589289838583 0.802317907773415 -0.253273703233256 0.375512080029025 MirTarget;miRanda;miRNATAP -0.177108211107202 5.14864677602474e-07 hsa-miR-429 JUN -0.142589289838583 0.802317907773415 -0.108657195258627 0.877583083771737 MirTarget;PITA;miRanda;miRNATAP -0.17100165827497 4.02284319393828e-13 hsa-miR-429 FBXW11 -0.142589289838583 0.802317907773415 0.00937498411107818 0.985997496641178 MirTarget;PITA;miRanda;miRNATAP -0.0745430625907807 1.40526740080511e-11 hsa-miR-450b-5p PPP3CB 0.140781738083346 0.700777724167455 0.0212980346837259 0.969289216388387 MirTarget;PITA;miRNATAP -0.0741011799432195 7.74219820151297e-06 hsa-miR-454-3p WNT2B -0.0807547300787816 0.779337172929459 -0.120458000644347 0.404153656056463 MirTarget -0.174716398885358 1.14167579103774e-07 hsa-miR-454-3p DAAM1 -0.0807547300787816 0.779337172929459 -0.0539991515887506 0.906596879539895 MirTarget;miRNATAP -0.0603234696686295 0.0390958344928716 hsa-miR-455-5p TBL1XR1 -0.196032525410701 0.627038966906064 -0.115313887374555 0.864767739366221 MirTarget;miRanda -0.0919269129376044 1.2034809991866e-07 hsa-miR-455-5p NLK -0.196032525410701 0.627038966906064 -0.0075726819422437 0.986090753913933 MirTarget;PITA;miRanda;miRNATAP -0.123543532954721 1.15133287100025e-10 hsa-miR-484 NFATC4 -0.167034215156431 0.771225151614856 0.118767632463774 0.80554796605913 MirTarget;miRNATAP -0.195541918029345 5.21748391548856e-06 hsa-miR-484 PRKCB -0.167034215156431 0.771225151614856 -0.253273703233256 0.375512080029025 MirTarget;miRNATAP -0.147301231927914 0.0114084132678022 hsa-miR-484 NFATC2 -0.167034215156431 0.771225151614856 -0.38368313501719 0.1310673127204 MirTarget -0.151179681981917 0.0247912913976171 hsa-miR-484 SFRP1 -0.167034215156431 0.771225151614856 -0.472006437969406 0.460625213922239 MirTarget -0.736652971526416 5.14194951874832e-12 hsa-miR-485-3p NLK -0.200882988600113 0.355387948738328 -0.0075726819422437 0.986090753913933 MirTarget;PITA;miRNATAP -0.115025747481124 5.816614344041e-09 hsa-miR-485-3p CTBP1 -0.200882988600113 0.355387948738328 -0.00426146109334713 0.994460970584857 MirTarget;PITA;miRNATAP -0.0753783348315207 8.60257691081771e-07 hsa-miR-485-3p CXXC4 -0.200882988600113 0.355387948738328 -0.189634120723988 0.402205830601326 MirTarget -0.129507483208911 0.0125618139631789 hsa-miR-493-5p FZD4 -0.284749337378863 0.305440922291611 0.0304707076358319 0.955399406040093 MirTarget;miRNATAP -0.0676939893289474 0.0428246548585275 22057916;22057916 Tumor suppressor microRNA-493 decreases cell motility and migration ability in human bladder cancer cells by downregulating RhoC and FZD4;miR-493 decreased 3'-untranslated region luciferase activity and protein expression of FZD4 and RhoC miR-493 also decreased binding of RhoC and Rock-1 miR-493 is a new tumor suppressor miRNA in bladder cancer and inhibits cell motility through downregulation of RhoC and FZD4 motility;;motility; bladder cancer;bladder cancer hsa-miR-495-3p TBL1XR1 -0.159204559213757 0.555240058524588 -0.115313887374555 0.864767739366221 MirTarget -0.0650372031854373 8.80545325415817e-05 hsa-miR-495-3p CCND1 -0.159204559213757 0.555240058524588 0.0138594286077627 0.985644356886489 MirTarget -0.2655760978611 1.39010362325337e-11 hsa-miR-500a-3p DAAM1 0.0799476415682276 0.907492204424754 -0.0539991515887506 0.906596879539895 MirTarget -0.182020512089716 2.32427170809983e-06 hsa-miR-500a-3p NFAT5 0.0799476415682276 0.907492204424754 -0.140634566870934 0.80102714017311 MirTarget -0.0749409337052392 0.0075747605469312 hsa-miR-500a-3p PPP2R5E 0.0799476415682276 0.907492204424754 -0.08594361639783 0.857732462812563 MirTarget -0.0706405377406934 0.00273277543962583 hsa-miR-503-5p CCND2 -0.00593778805044032 0.98457775641254 -0.168931301767903 0.722558871099741 MirTarget -0.074275790492991 0.000914806017585067 hsa-miR-505-3p BTRC -0.245807419731662 0.59093461248251 -0.113796391872094 0.818463431452382 MirTarget -0.19714346161221 2.15462077391573e-20 hsa-miR-511-5p SKP1 -0.310767354974383 0.310390422401541 0.11984894684252 0.870895899955478 MirTarget -0.0784856241501618 1.35270082389214e-12 hsa-miR-511-5p CCND1 -0.310767354974383 0.310390422401541 0.0138594286077627 0.985644356886489 MirTarget -0.21938803198833 1.27831310404617e-13 hsa-miR-511-5p NLK -0.310767354974383 0.310390422401541 -0.0075726819422437 0.986090753913933 MirTarget -0.0924403491745174 1.88106077326446e-11 hsa-miR-532-5p CXXC4 0.0193679288578856 0.981424049788362 -0.189634120723988 0.402205830601326 MirTarget;PITA;miRNATAP -0.496712025500665 4.77750045893798e-12 hsa-miR-532-5p SFRP4 0.0193679288578856 0.981424049788362 -0.0657313828955362 0.911276471082622 MirTarget -0.348327615827745 2.35831438297707e-06 hsa-miR-542-3p TBL1XR1 0.11706603007597 0.867078497673182 -0.115313887374555 0.864767739366221 MirTarget;PITA;miRanda -0.113018558915214 2.3915716506794e-08 hsa-miR-589-3p PRICKLE2 -0.0679748049633819 0.703146664597157 0.0177255412987654 0.969497997086328 MirTarget -0.131279359595792 4.29454967061397e-06 hsa-miR-589-3p CCND1 -0.0679748049633819 0.703146664597157 0.0138594286077627 0.985644356886489 MirTarget -0.116809863299678 0.00155105242627909 hsa-miR-589-3p CAMK2B -0.0679748049633819 0.703146664597157 0.141283778852512 0.60471522191955 MirTarget -0.282678683570449 6.81881545878125e-07 hsa-miR-589-5p PRICKLE2 -0.0214815940746442 0.967157138449855 0.0177255412987654 0.969497997086328 MirTarget;miRNATAP -0.410788762794066 5.39765560115147e-16 hsa-miR-589-5p CXXC4 -0.0214815940746442 0.967157138449855 -0.189634120723988 0.402205830601326 MirTarget;miRNATAP -0.397030086932275 6.52239923121845e-07 hsa-miR-590-3p PRICKLE2 -0.133358268237272 0.535686159072243 0.0177255412987654 0.969497997086328 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.428246782039215 4.12749671901844e-37 hsa-miR-590-3p AXIN2 -0.133358268237272 0.535686159072243 -0.0138759668242621 0.966117623520896 MirTarget;PITA;miRanda;miRNATAP -0.363534362507334 4.95187752463635e-26 hsa-miR-590-3p SMAD4 -0.133358268237272 0.535686159072243 -0.0337260829637342 0.952673159973339 MirTarget;PITA;miRanda;miRNATAP -0.088164834648131 2.90407325908758e-07 hsa-miR-590-3p NFAT5 -0.133358268237272 0.535686159072243 -0.140634566870934 0.80102714017311 MirTarget;miRanda;mirMAP;miRNATAP -0.100697433581401 1.88485706745528e-05 hsa-miR-590-3p DAAM1 -0.133358268237272 0.535686159072243 -0.0539991515887506 0.906596879539895 MirTarget;miRanda;mirMAP -0.118654937699321 0.000263360597662213 hsa-miR-590-5p PRICKLE2 -0.131787544750195 0.684613701486826 0.0177255412987654 0.969497997086328 MirTarget;PITA;miRanda -0.400059229125334 2.18643891880232e-35 hsa-miR-625-5p TCF7L2 -0.121097781227008 0.486746151168725 -0.151922190442888 0.739870566881007 MirTarget -0.196349842308205 7.37475139500119e-12 hsa-miR-625-5p SFRP1 -0.121097781227008 0.486746151168725 -0.472006437969406 0.460625213922239 MirTarget -0.628996046116407 2.3830320131247e-12 hsa-miR-629-3p PRICKLE2 -0.203962319893151 0.416043359122368 0.0177255412987654 0.969497997086328 MirTarget -0.17392475751545 7.91638698760279e-11 hsa-miR-664a-3p TCF7L2 0.0260321839026805 0.956434140422838 -0.151922190442888 0.739870566881007 MirTarget -0.0976005539199438 0.00911575907440828 hsa-miR-671-5p SMAD3 0.0238736022615038 0.908889383230195 -0.00805727245311783 0.987902560465751 MirTarget -0.132445297015047 2.33568059728177e-10 hsa-miR-7-1-3p FZD8 -0.0332815306858167 0.935725386085843 -0.078904880304417 0.834803608799275 MirTarget -0.285864089758394 6.15672183615667e-14 hsa-miR-7-1-3p PRICKLE2 -0.0332815306858167 0.935725386085843 0.0177255412987654 0.969497997086328 MirTarget -0.19024658377573 1.21829464745801e-08 hsa-miR-7-1-3p CAMK2A -0.0332815306858167 0.935725386085843 -0.202058295390148 0.395922649310232 MirTarget -0.262098249281639 8.03032900468887e-09 hsa-miR-7-1-3p SFRP1 -0.0332815306858167 0.935725386085843 -0.472006437969406 0.460625213922239 MirTarget;mirMAP -0.630150561051086 2.75485010272039e-12 hsa-miR-708-3p CXXC4 -0.0786820348913011 0.88886515820271 -0.189634120723988 0.402205830601326 MirTarget -0.255893073883026 2.2233000962564e-05 hsa-miR-889-3p FBXW11 -0.0891386913656023 0.781493366587911 0.00937498411107818 0.985997496641178 MirTarget -0.0872176795028287 5.20261425808359e-09 hsa-miR-889-3p SMAD2 -0.0891386913656023 0.781493366587911 -0.0519399062136339 0.930776806456225 MirTarget -0.0764186857472352 4.12381359190026e-09 hsa-miR-889-3p TBL1XR1 -0.0891386913656023 0.781493366587911 -0.115313887374555 0.864767739366221 MirTarget -0.136425907469045 3.79884694261387e-15 hsa-miR-889-3p CXXC4 -0.0891386913656023 0.781493366587911 -0.189634120723988 0.402205830601326 MirTarget -0.216720712252581 1.93828204405402e-05 hsa-miR-92a-3p NLK -0.0230307937945682 0.984317735692711 -0.0075726819422437 0.986090753913933 MirTarget;miRNATAP -0.108248489207265 2.75005198560074e-05 hsa-miR-92a-3p CAMK2A -0.0230307937945682 0.984317735692711 -0.202058295390148 0.395922649310232 MirTarget -0.281889994119232 1.60654390365786e-06 hsa-miR-93-5p NFAT5 0.0554251653547535 0.959380932710413 -0.140634566870934 0.80102714017311 MirTarget;miRNATAP -0.248552951648198 4.68674105390296e-21 hsa-miR-942-5p CREBBP -0.114486919487105 0.623023233194388 -0.121528460671809 0.849036225288355 MirTarget -0.0723534657547835 1.26909739768754e-06 hsa-miR-942-5p CCND1 -0.114486919487105 0.623023233194388 0.0138594286077627 0.985644356886489 MirTarget -0.261175156275166 1.39422778172566e-10 hsa-miR-96-5p FBXW11 -0.153312892459014 0.726115467443483 0.00937498411107818 0.985997496641178 MirTarget;TargetScan;miRNATAP -0.0566980001221246 9.95237168869186e-07 hsa-miR-96-5p TCF7L2 -0.153312892459014 0.726115467443483 -0.151922190442888 0.739870566881007 MirTarget;TargetScan;miRNATAP -0.237827941772781 2.94405056699388e-29 hsa-miR-98-5p FZD4 0.0782917740368987 0.880173437070493 0.0304707076358319 0.955399406040093 MirTarget -0.528062971038367 1.52945921080448e-21 hsa-miR-99b-3p TCF7L2 -0.0489959968350426 0.929197470973416 -0.151922190442888 0.739870566881007 MirTarget;miRNATAP -0.144432671942689 4.79981484254922e-05 hsa-miR-99b-5p FZD8 -0.0532361324205564 0.968742875695634 -0.078904880304417 0.834803608799275 MirTarget -0.27167361740119 1.84979575053296e-08 hsa-miR-330-3p APC -0.00366157141494194 0.98416704678615 -0.0723635628413355 0.883189867616246 PITA;mirMAP -0.0645641300453699 0.00832548895595641 hsa-miR-590-3p APC -0.133358268237272 0.535686159072243 -0.0723635628413355 0.883189867616246 PITA;miRanda;mirMAP;miRNATAP -0.118033171177274 5.72074719287459e-07 hsa-miR-142-5p PPP3CA -0.35195621065247 0.488286772825655 -0.078895894384611 0.886413963353503 PITA;mirMAP;miRNATAP -0.0517006705110423 0.010073687072875 hsa-miR-542-3p SMAD2 0.11706603007597 0.867078497673182 -0.0519399062136339 0.930776806456225 PITA -0.104251622984305 3.31535587210055e-12 hsa-miR-450b-5p SIAH1 0.140781738083346 0.700777724167455 -0.105259829109209 0.810276326122422 PITA;miRNATAP -0.0516186129020608 0.00266493982752715 hsa-miR-339-3p CTBP1 -0.111910400391857 0.706068811907603 -0.00426146109334713 0.994460970584857 PITA -0.0548577628841921 0.00742823491742073 hsa-miR-107 CSNK1A1 -0.00374429919903285 0.994322461958742 -0.0165042555609478 0.982452723332151 PITA;miRanda;miRNATAP -0.122179164718018 1.10059616048406e-07 hsa-miR-361-5p CREBBP 0.0775639231585332 0.909963521897996 -0.121528460671809 0.849036225288355 PITA;miRanda;miRNATAP -0.169327426710038 1.27069129226647e-06 hsa-miR-590-3p CREBBP -0.133358268237272 0.535686159072243 -0.121528460671809 0.849036225288355 PITA;miRanda;mirMAP;miRNATAP -0.100564166407458 8.68617817381304e-10 hsa-miR-361-3p EP300 -0.0127254134873924 0.984476698818773 -0.0381739592699031 0.951249053975231 PITA -0.139187579360879 0.000249736724501524 hsa-miR-486-5p CSNK2A1 0.00521803679905908 0.992702666093128 0.0222385179144631 0.968143761360086 PITA;miRanda -0.0619910506843221 2.2950762233224e-11 hsa-miR-199b-5p GSK3B -0.0420618710265854 0.953083764782006 -0.0660851428212252 0.908304623747486 PITA;miRanda;miRNATAP -0.0738697643279942 7.62526261918686e-06 hsa-miR-450b-5p LRP6 0.140781738083346 0.700777724167455 -0.261612069159627 0.621254118198097 PITA;mirMAP;miRNATAP -0.0627756833884434 0.0229815300056717 hsa-miR-671-5p LRP6 0.0238736022615038 0.908889383230195 -0.261612069159627 0.621254118198097 PITA -0.0958880000718063 0.000109109993324378 hsa-miR-107 PPP2R5C -0.00374429919903285 0.994322461958742 -0.0241791959006408 0.968345143230327 PITA;miRanda;miRNATAP -0.0771011742398348 3.13164126653915e-05 hsa-miR-146b-5p PRKACA 0.00834882458611474 0.991577009242932 -0.0115056231029671 0.985176457562246 PITA -0.0531061870671599 0.000152525533332548 hsa-miR-532-5p PRKACB 0.0193679288578856 0.981424049788362 -0.0742837105484302 0.886731753016865 PITA -0.167904290632964 0.00255889279358267 hsa-miR-590-3p PRKCA -0.133358268237272 0.535686159072243 -0.227245147154052 0.467261641689546 PITA;miRanda;mirMAP;miRNATAP -0.0919369646323256 0.0215881463488136 hsa-miR-361-5p MAPK8 0.0775639231585332 0.909963521897996 -0.267537090166021 0.457115846208038 PITA;miRanda;mirMAP -0.36263548128247 3.21553639920568e-09 hsa-miR-330-3p MAPK10 -0.00366157141494194 0.98416704678615 -0.469554749724375 0.0904444026222832 PITA;miRNATAP -0.240537820613709 6.0605250152691e-05 hsa-miR-590-5p MAPK10 -0.131787544750195 0.684613701486826 -0.469554749724375 0.0904444026222832 PITA;miRanda;miRNATAP -0.208756960356003 0.000174508852265274 hsa-miR-330-3p FZD5 -0.00366157141494194 0.98416704678615 -0.186395173219289 0.518902590417545 PITA;mirMAP;miRNATAP -0.0874484088379012 0.00764864315732441 hsa-miR-342-3p FZD5 -0.244092268513731 0.741215180994683 -0.186395173219289 0.518902590417545 PITA -0.25230820365646 7.06125013894829e-20 hsa-miR-320b BTRC -0.0203395214664157 0.930562048282019 -0.113796391872094 0.818463431452382 PITA -0.0760715661845117 0.00104600713566941 hsa-miR-369-3p ROCK2 -0.0734607425694875 0.755351791463265 -0.273205140377062 0.589812182930179 PITA -0.0797264564664897 0.0390769081549399 hsa-miR-429 ROCK2 -0.142589289838583 0.802317907773415 -0.273205140377062 0.589812182930179 PITA;miRanda;miRNATAP -0.205818358236693 4.93110698663187e-15 hsa-miR-125a-5p RAC3 0.00741438556537055 0.993308396064258 0.126720733441036 0.727850785944667 PITA -0.214154670070607 8.31103753734932e-06 hsa-miR-146b-5p SMAD4 0.00834882458611474 0.991577009242932 -0.0337260829637342 0.952673159973339 PITA;miRanda;miRNATAP -0.13881112685924 1.84558785229961e-14 hsa-miR-429 SMAD4 -0.142589289838583 0.802317907773415 -0.0337260829637342 0.952673159973339 PITA;miRanda;miRNATAP -0.0739655521525238 3.65996392590515e-10 hsa-miR-337-3p FRAT1 -0.261670200477266 0.586287331335225 0.0717364474803182 0.782088380245773 PITA -0.0850505561582483 1.25599833507213e-05 hsa-miR-142-5p SMAD3 -0.35195621065247 0.488286772825655 -0.00805727245311783 0.987902560465751 PITA -0.0900603692355694 1.94054167645626e-07 24558198 On TGF-β1 stimulation stable overexpression of miR-142-3p attenuated phosphorylation of SMAD3 an indispensable downstream effector in canonical TGF-β/Smad signaling via repression of TGFβR1 in A549 cells lung cancer hsa-miR-654-3p PPP2R5D -0.187928566892617 0.631807992098329 0.0854554677410553 0.877127199238575 PITA;miRNATAP -0.0627774217495763 1.52023588762598e-07 hsa-miR-330-3p WIF1 -0.00366157141494194 0.98416704678615 -0.478550730412641 0.298949947494155 PITA;miRNATAP -0.303568377711378 0.0147013444545922 hsa-miR-590-3p WIF1 -0.133358268237272 0.535686159072243 -0.478550730412641 0.298949947494155 PITA;miRanda;mirMAP -0.639334008119333 9.64663705878253e-08 hsa-miR-455-3p FZD10 -0.332546859679539 0.617979023781481 -0.157448402775842 0.382566977418384 PITA;miRNATAP -0.126579766449709 7.04423244264842e-05 hsa-miR-484 FZD4 -0.167034215156431 0.771225151614856 0.0304707076358319 0.955399406040093 PITA -0.212116451539721 1.28850151052031e-06 hsa-miR-582-5p FZD4 -0.25536438153407 0.299823930850699 0.0304707076358319 0.955399406040093 PITA;miRNATAP -0.128558705031842 0.000254827247268146 hsa-miR-142-5p FBXW11 -0.35195621065247 0.488286772825655 0.00937498411107818 0.985997496641178 PITA -0.070391007866995 1.61640552782508e-08 hsa-miR-217 FBXW11 -0.0872981480242543 0.809509315744678 0.00937498411107818 0.985997496641178 PITA;miRanda -0.0579581679580123 5.62363018545375e-06 hsa-miR-369-3p FBXW11 -0.0734607425694875 0.755351791463265 0.00937498411107818 0.985997496641178 PITA;mirMAP;miRNATAP -0.0750437985825293 2.95193176084198e-06 hsa-miR-423-5p NFATC2 -0.0275038364546472 0.956931958131863 -0.38368313501719 0.1310673127204 PITA -0.329350686391576 0.000107038916546868 hsa-miR-107 PLCB1 -0.00374429919903285 0.994322461958742 0.16954029991043 0.64744751250053 PITA;miRanda;miRNATAP -0.43540927048432 3.17440164078589e-09 hsa-miR-590-3p PLCB1 -0.133358268237272 0.535686159072243 0.16954029991043 0.64744751250053 PITA;miRanda;mirMAP -0.163197561436935 0.00104240143511447 hsa-miR-509-3p CAMK2A -0.351616315142863 0.106518641186923 -0.202058295390148 0.395922649310232 PITA -0.0922657927531937 0.00691999844727706 hsa-miR-139-5p FZD3 0.00543145985495741 0.991591290852214 -0.0249834874630155 0.930139178962665 PITA;miRanda -0.114417639453248 1.43759918418206e-05 hsa-miR-338-3p FZD3 -0.00932885158849928 0.989745642009026 -0.0249834874630155 0.930139178962665 PITA;miRanda -0.111182152623386 0.000317238435661394 hsa-miR-107 TBL1XR1 -0.00374429919903285 0.994322461958742 -0.115313887374555 0.864767739366221 PITA;miRanda;miRNATAP -0.0818628265126129 0.00370388151139759 hsa-miR-140-3p TBL1XR1 -0.0813609197213889 0.923953795876038 -0.115313887374555 0.864767739366221 PITA -0.222142997474086 4.16347181412021e-26 hsa-miR-34c-3p TBL1XR1 0.130155071459505 0.516764839177917 -0.115313887374555 0.864767739366221 PITA;mirMAP;miRNATAP -0.0664144321245772 5.52177185255902e-05 hsa-miR-369-3p TBL1XR1 -0.0734607425694875 0.755351791463265 -0.115313887374555 0.864767739366221 PITA;mirMAP -0.0805169332700951 1.90230087460113e-05 hsa-miR-532-5p NKD1 0.0193679288578856 0.981424049788362 -0.180903345728981 0.226242418703525 PITA;miRNATAP -0.121825130176435 0.0248596546919663 hsa-miR-142-5p CCND1 -0.35195621065247 0.488286772825655 0.0138594286077627 0.985644356886489 PITA -0.210173449112337 1.63510921192815e-09 23619912 Transfection of miR-142-3p mimics in colon cancer cells downregulated cyclin D1 expression induced G1 phase cell cycle arrest and elevated the sensitivity of the cells to 5-fluorouracil colorectal cancer hsa-miR-362-5p PRKACB 0.215268517371166 0.469421708227034 -0.0742837105484302 0.886731753016865 PITA -0.175108655019306 3.25359783331258e-06 hsa-miR-200b-3p CAMK2D -0.109983892590611 0.891357972128093 -0.130338203405614 0.785364834465144 TargetScan;mirMAP -0.176484130686564 3.1915455415824e-14 hsa-miR-96-5p CCND2 -0.153312892459014 0.726115467443483 -0.168931301767903 0.722558871099741 TargetScan;miRNATAP -0.311897703713413 7.58506265459077e-49 hsa-miR-501-3p CSNK1A1 0.0142885468386682 0.976243386478648 -0.0165042555609478 0.982452723332151 TargetScan;miRNATAP -0.102750322971741 1.05636462078204e-10 hsa-miR-17-5p CSNK1A1 -0.0085894792332244 0.990927211793889 -0.0165042555609478 0.982452723332151 TargetScan -0.139354338789202 6.20716702675882e-24 hsa-miR-96-5p DAAM1 -0.153312892459014 0.726115467443483 -0.0539991515887506 0.906596879539895 TargetScan;miRNATAP -0.102839541953941 1.06315967280966e-05 hsa-let-7a-5p DVL3 -0.0656092877172174 0.961124733677684 0.00975763465514845 0.987406911304736 TargetScan -0.103667059737757 1.12037250327915e-06 hsa-miR-96-5p EP300 -0.153312892459014 0.726115467443483 -0.0381739592699031 0.951249053975231 TargetScan;miRNATAP -0.0595632604448432 0.000290513265618238 hsa-miR-17-5p FBXW11 -0.0085894792332244 0.990927211793889 0.00937498411107818 0.985997496641178 TargetScan;miRNATAP -0.0885332550236822 1.48435313488611e-09 hsa-miR-141-3p FZD4 -0.179420502124191 0.83354105481228 0.0304707076358319 0.955399406040093 TargetScan -0.485144243770508 8.88244662789011e-86 hsa-miR-17-5p FZD4 -0.0085894792332244 0.990927211793889 0.0304707076358319 0.955399406040093 TargetScan -0.379930791437764 1.81308518580408e-28 hsa-miR-96-5p LRP6 -0.153312892459014 0.726115467443483 -0.261612069159627 0.621254118198097 TargetScan;miRNATAP -0.11391896975426 1.48551831367243e-09 hsa-miR-200b-3p NKD1 -0.109983892590611 0.891357972128093 -0.180903345728981 0.226242418703525 TargetScan -0.0773271651164611 0.0142030153037924 hsa-let-7a-5p NKD1 -0.0656092877172174 0.961124733677684 -0.180903345728981 0.226242418703525 TargetScan -0.285119479952564 1.26690218381995e-05 hsa-miR-17-5p PLCB1 -0.0085894792332244 0.990927211793889 0.16954029991043 0.64744751250053 TargetScan;miRNATAP -0.14694574384319 0.00121463038460002 hsa-miR-96-5p PLCB4 -0.153312892459014 0.726115467443483 0.0386799314732373 0.922546084561183 TargetScan;miRNATAP -0.157435127267557 2.40435360053082e-05 hsa-miR-141-3p PLCB4 -0.179420502124191 0.83354105481228 0.0386799314732373 0.922546084561183 TargetScan -0.129122335963341 0.000435434137519319 hsa-miR-362-5p PPP2CA 0.215268517371166 0.469421708227034 0.0284217367477391 0.96534362029265 TargetScan -0.0585906903629201 2.80979771025798e-06 hsa-miR-17-5p PPP2CA -0.0085894792332244 0.990927211793889 0.0284217367477391 0.96534362029265 TargetScan -0.0598139731984396 2.30783397825974e-06 hsa-miR-96-5p PPP3CA -0.153312892459014 0.726115467443483 -0.078895894384611 0.886413963353503 TargetScan -0.0887843307683919 1.70141567871087e-06 hsa-miR-141-3p PRICKLE1 -0.179420502124191 0.83354105481228 -0.101221821514089 0.815959595958142 TargetScan -0.110970210955193 3.06180806587071e-06 hsa-miR-17-5p PRKACB -0.0085894792332244 0.990927211793889 -0.0742837105484302 0.886731753016865 TargetScan -0.167470485926017 1.11326049159611e-05 hsa-miR-200b-3p PRKCA -0.109983892590611 0.891357972128093 -0.227245147154052 0.467261641689546 TargetScan -0.338107140907763 7.43601898887161e-30 hsa-miR-17-5p PSEN1 -0.0085894792332244 0.990927211793889 -0.0685344526261558 0.908564158711858 TargetScan -0.0814772900708477 1.69423733585806e-10 hsa-miR-200b-3p ROCK2 -0.109983892590611 0.891357972128093 -0.273205140377062 0.589812182930179 TargetScan -0.238045362418837 5.70621727270586e-16 hsa-miR-141-3p SOX17 -0.179420502124191 0.83354105481228 0.0131444970555261 0.950901967500152 TargetScan -0.426856956954328 5.06746881736312e-61 hsa-miR-141-3p WNT5A -0.179420502124191 0.83354105481228 -0.37564066226164 0.355542462686927 TargetScan -0.139214845204003 2.12785375749739e-05 hsa-miR-28-5p NLK -0.212713060051394 0.714914931441106 -0.0075726819422437 0.986090753913933 miRanda -0.182841180159811 4.4803820168759e-07 hsa-miR-28-5p BTRC -0.212713060051394 0.714914931441106 -0.113796391872094 0.818463431452382 miRanda -0.245382923565365 1.23962341723426e-09 hsa-miR-107 TCF7L2 -0.00374429919903285 0.994322461958742 -0.151922190442888 0.739870566881007 miRanda -0.247661729975441 3.82905437520373e-08 hsa-miR-107 TCF7 -0.00374429919903285 0.994322461958742 -0.190752137435303 0.611949137914896 miRanda -0.117353523993891 0.0433465482308839 hsa-miR-107 APC -0.00374429919903285 0.994322461958742 -0.0723635628413355 0.883189867616246 miRanda -0.266050961631061 1.99405735689927e-14 hsa-miR-107 WIF1 -0.00374429919903285 0.994322461958742 -0.478550730412641 0.298949947494155 miRanda -0.805243011250718 6.66023850485786e-06 hsa-miR-107 PPP3CB -0.00374429919903285 0.994322461958742 0.0212980346837259 0.969289216388387 miRanda -0.128823034238509 4.39638835494672e-08 hsa-miR-107 MAP3K7 -0.00374429919903285 0.994322461958742 -0.104962611573905 0.825259838393628 miRanda -0.0861128825674717 0.00113812431599321 hsa-miR-107 ROCK1 -0.00374429919903285 0.994322461958742 -0.172548975888922 0.760861741105756 miRanda -0.214652817656713 7.4445514442289e-10 hsa-miR-107 PPP2R5A -0.00374429919903285 0.994322461958742 0.0837534785515848 0.890977423101542 miRanda -0.116676163127242 0.000291888356596273 hsa-miR-107 FZD10 -0.00374429919903285 0.994322461958742 -0.157448402775842 0.382566977418384 miRanda -0.400790225805032 2.23315200602984e-08 hsa-miR-107 PSEN1 -0.00374429919903285 0.994322461958742 -0.0685344526261558 0.908564158711858 miRanda -0.0545105167602204 0.00947565654248396 hsa-miR-199a-5p PPP2R1A -0.0114843373708311 0.9900489817393 0.0981760857696141 0.894638367692319 miRanda -0.0559524497282798 0.00105266363104996 hsa-miR-139-5p PPP2R5E 0.00543145985495741 0.991591290852214 -0.08594361639783 0.857732462812563 miRanda -0.0536764631352474 0.00029888690003241 hsa-miR-139-5p NLK 0.00543145985495741 0.991591290852214 -0.0075726819422437 0.986090753913933 miRanda -0.103239444031536 3.35421799377228e-11 hsa-miR-139-5p MAPK9 0.00543145985495741 0.991591290852214 -0.00950322920821378 0.985902275586564 miRanda -0.0663892919843547 5.2803083327577e-07 hsa-miR-139-5p VANGL2 0.00543145985495741 0.991591290852214 -0.491521821831935 0.31936517526481 miRanda -0.0865858263514659 0.0392593763892865 hsa-miR-139-5p VANGL1 0.00543145985495741 0.991591290852214 -0.0952455706302153 0.850760454545912 miRanda -0.161777639176173 6.00227916383558e-22 hsa-miR-139-5p RBX1 0.00543145985495741 0.991591290852214 0.11597267591947 0.817045814738048 miRanda -0.138659130309957 7.99349725093936e-22 hsa-miR-139-5p WNT2 0.00543145985495741 0.991591290852214 -0.0704278884095242 0.817871130365495 miRanda -0.250813000106968 6.69310140321002e-11 hsa-miR-199b-5p MAPK9 -0.0420618710265854 0.953083764782006 -0.00950322920821378 0.985902275586564 miRanda -0.0518067608887246 0.00180618315758014 hsa-miR-199b-5p PPP2R1A -0.0420618710265854 0.953083764782006 0.0981760857696141 0.894638367692319 miRanda -0.0924456255215766 1.59185765000013e-09 hsa-miR-217 NLK -0.0872981480242543 0.809509315744678 -0.0075726819422437 0.986090753913933 miRanda -0.107421092941157 6.83560697467638e-11 hsa-miR-217 TBL1XR1 -0.0872981480242543 0.809509315744678 -0.115313887374555 0.864767739366221 miRanda -0.073697145223838 8.10242612767762e-07 hsa-miR-217 GSK3B -0.0872981480242543 0.809509315744678 -0.0660851428212252 0.908304623747486 miRanda -0.0617237210156793 9.99990610772898e-06 hsa-miR-140-5p NKD1 -0.310979285894735 0.512489148244786 -0.180903345728981 0.226242418703525 miRanda -0.100904832941356 0.0421314604872354 hsa-miR-140-5p MAPK9 -0.310979285894735 0.512489148244786 -0.00950322920821378 0.985902275586564 miRanda -0.0847411795505585 8.23948959390374e-05 hsa-miR-140-5p CXXC4 -0.310979285894735 0.512489148244786 -0.189634120723988 0.402205830601326 miRanda -0.132297143749825 0.0468117068070835 hsa-miR-140-5p RUVBL1 -0.310979285894735 0.512489148244786 0.132172450685464 0.800766443652738 miRanda -0.115192679042016 8.12213333695103e-06 hsa-miR-142-3p DVL1 -0.419981832465888 0.660228548488659 -0.0106489854425629 0.983281417437041 miRanda -0.0834858108532135 8.01966055435947e-06 hsa-miR-142-3p SKP1 -0.419981832465888 0.660228548488659 0.11984894684252 0.870895899955478 miRanda -0.0750202865852105 2.92710918256477e-11 hsa-miR-142-3p WNT5A -0.419981832465888 0.660228548488659 -0.37564066226164 0.355542462686927 miRanda -0.0731921709718467 0.0194126739295489 hsa-miR-142-3p CCND1 -0.419981832465888 0.660228548488659 0.0138594286077627 0.985644356886489 miRanda -0.111966511365121 0.000240262100008297 23619912 Transfection of miR-142-3p mimics in colon cancer cells downregulated cyclin D1 expression induced G1 phase cell cycle arrest and elevated the sensitivity of the cells to 5-fluorouracil colorectal cancer hsa-miR-142-3p FZD7 -0.419981832465888 0.660228548488659 -0.175347860746907 0.737019399304957 miRanda -0.0689851582630723 0.0044975787062294 hsa-miR-125a-5p NKD1 0.00741438556537055 0.993308396064258 -0.180903345728981 0.226242418703525 miRanda -0.278399457854937 1.03346527875826e-07 hsa-miR-125a-5p PORCN 0.00741438556537055 0.993308396064258 0.0251013949056911 0.933796057958978 miRanda -0.0530686185220666 0.022029590201529 hsa-miR-125a-5p PRICKLE1 0.00741438556537055 0.993308396064258 -0.101221821514089 0.815959595958142 miRanda -0.100102075572689 0.0215276812440828 hsa-miR-125a-5p PLCB3 0.00741438556537055 0.993308396064258 0.118375767075563 0.808132780263958 miRanda -0.184282319096659 4.86720731110882e-12 hsa-miR-125a-5p FRAT2 0.00741438556537055 0.993308396064258 -0.0156891928833645 0.96774417787488 miRanda -0.122529541273626 1.62004842950428e-05 hsa-miR-125a-3p NKD2 -0.0516703286850553 0.806463674361179 0.121258128388302 0.63474965799198 miRanda -0.119765093394375 0.0474286895674221 hsa-miR-125a-3p FZD1 -0.0516703286850553 0.806463674361179 -0.147165722412794 0.785892420221886 miRanda -0.0765166217405975 0.0196673917676087 hsa-miR-125a-3p BTRC -0.0516703286850553 0.806463674361179 -0.113796391872094 0.818463431452382 miRanda -0.0742961430698338 0.00670380741008166 hsa-miR-193a-3p TCF7L2 -0.0143163678163178 0.969244019090322 -0.151922190442888 0.739870566881007 miRanda -0.13669345972878 7.45997149176231e-05 hsa-miR-193a-3p NFAT5 -0.0143163678163178 0.969244019090322 -0.140634566870934 0.80102714017311 miRanda -0.0627955089282072 0.0191949867111344 hsa-miR-193a-3p DAAM2 -0.0143163678163178 0.969244019090322 -0.0621191173439439 0.879009045386603 miRanda -0.165858100319702 0.000144893895245171 hsa-miR-193a-3p DKK2 -0.0143163678163178 0.969244019090322 0.299403293390667 0.169274319749997 miRanda -0.19209434845159 0.000113861738873523 hsa-miR-193a-3p NFATC4 -0.0143163678163178 0.969244019090322 0.118767632463774 0.80554796605913 miRanda -0.105543408753107 0.0146751830382174 hsa-miR-193a-3p LRP6 -0.0143163678163178 0.969244019090322 -0.261612069159627 0.621254118198097 miRanda -0.073906549165103 0.013739338284399 hsa-miR-193a-3p PLCB2 -0.0143163678163178 0.969244019090322 0.046924896357516 0.890573590890969 miRanda -0.0765221456302134 0.0219110979628161 hsa-miR-320a MAPK9 0.0425274543382255 0.958191670788918 -0.00950322920821378 0.985902275586564 miRanda;miRNATAP -0.060350857004848 0.0143944954891813 hsa-miR-320a GSK3B 0.0425274543382255 0.958191670788918 -0.0660851428212252 0.908304623747486 miRanda;mirMAP -0.129942826481556 1.0429094971177e-07 hsa-miR-320a APC 0.0425274543382255 0.958191670788918 -0.0723635628413355 0.883189867616246 miRanda -0.0914574706233465 0.00547299253170965 hsa-miR-320a ROCK1 0.0425274543382255 0.958191670788918 -0.172548975888922 0.760861741105756 miRanda -0.0684779206018823 0.0370901073300847 hsa-miR-320a CAMK2G 0.0425274543382255 0.958191670788918 0.119349300317351 0.7992742190937 miRanda -0.0739236305080279 0.000466392794574208 hsa-miR-320a DAAM1 0.0425274543382255 0.958191670788918 -0.0539991515887506 0.906596879539895 miRanda -0.164568986730623 0.00026548350856992 hsa-miR-34c-5p PPP3R1 0.0263265725823381 0.923214932412527 -0.0271826487262787 0.962679518571233 miRanda -0.093920369071247 4.84069239951161e-14 hsa-miR-34c-5p CAMK2D 0.0263265725823381 0.923214932412527 -0.130338203405614 0.785364834465144 miRanda -0.0663587800253609 0.00823450501714772 hsa-miR-34c-5p PPP2R5D 0.0263265725823381 0.923214932412527 0.0854554677410553 0.877127199238575 miRanda -0.09083677453254 1.08483619895963e-14 hsa-miR-34c-5p DVL3 0.0263265725823381 0.923214932412527 0.00975763465514845 0.987406911304736 miRanda -0.0661446385225833 1.10402111018516e-09 hsa-miR-34c-5p EP300 0.0263265725823381 0.923214932412527 -0.0381739592699031 0.951249053975231 miRanda -0.0562380402915782 0.00276161473750972 hsa-miR-34c-5p PPP2R5E 0.0263265725823381 0.923214932412527 -0.08594361639783 0.857732462812563 miRanda -0.0718774321621184 9.64929616446417e-06 hsa-miR-34c-5p RUVBL1 0.0263265725823381 0.923214932412527 0.132172450685464 0.800766443652738 miRanda -0.100087979601338 8.64529686751099e-09 hsa-miR-361-5p PPP2R5E 0.0775639231585332 0.909963521897996 -0.08594361639783 0.857732462812563 miRanda -0.362844376404808 1.47810752731031e-18 hsa-miR-361-5p NKD1 0.0775639231585332 0.909963521897996 -0.180903345728981 0.226242418703525 miRanda -0.242196570817123 0.00520088014824435 hsa-miR-361-5p MAPK9 0.0775639231585332 0.909963521897996 -0.00950322920821378 0.985902275586564 miRanda -0.302539307267532 3.19615101156316e-16 hsa-miR-361-5p NFATC3 0.0775639231585332 0.909963521897996 -0.00280369997980578 0.995287940001814 miRanda -0.178329966960041 1.80837796087919e-06 hsa-miR-361-5p FZD3 0.0775639231585332 0.909963521897996 -0.0249834874630155 0.930139178962665 miRanda;miRNATAP -0.262866332902642 0.000447138915298169 hsa-miR-361-5p PPP3CA 0.0775639231585332 0.909963521897996 -0.078895894384611 0.886413963353503 miRanda -0.244052441662145 8.38230854446672e-06 hsa-miR-361-5p PLCB4 0.0775639231585332 0.909963521897996 0.0386799314732373 0.922546084561183 miRanda -0.243037400239062 0.0276985603373769 hsa-miR-361-5p PPP3CB 0.0775639231585332 0.909963521897996 0.0212980346837259 0.969289216388387 miRanda -0.218861370922051 6.00579314883281e-11 hsa-miR-361-5p PRKACB 0.0775639231585332 0.909963521897996 -0.0742837105484302 0.886731753016865 miRanda -0.31917046064862 0.000326749716630808 hsa-miR-361-5p DKK2 0.0775639231585332 0.909963521897996 0.299403293390667 0.169274319749997 miRanda -0.184249963165667 0.048511583389329 hsa-miR-361-5p PSEN1 0.0775639231585332 0.909963521897996 -0.0685344526261558 0.908564158711858 miRanda -0.201624103764595 1.00858341777568e-11 hsa-miR-375 CSNK2A2 0.324254910768071 0.784908661939924 0.0688758448404903 0.868207990737335 miRanda -0.061058385799049 6.36996938653457e-13 hsa-miR-330-5p SMAD3 -0.0582594636115701 0.896794748650637 -0.00805727245311783 0.987902560465751 miRanda -0.106180722787539 5.07248451793749e-05 hsa-miR-330-5p NKD1 -0.0582594636115701 0.896794748650637 -0.180903345728981 0.226242418703525 miRanda;miRNATAP -0.101487696032293 0.0339225254688308 hsa-miR-330-5p WIF1 -0.0582594636115701 0.896794748650637 -0.478550730412641 0.298949947494155 miRanda -0.660990097984299 2.58056748637709e-06 hsa-miR-330-5p WNT5A -0.0582594636115701 0.896794748650637 -0.37564066226164 0.355542462686927 miRanda -0.254694138871707 2.53849290717674e-06 hsa-miR-330-5p FZD4 -0.0582594636115701 0.896794748650637 0.0304707076358319 0.955399406040093 miRanda;miRNATAP -0.413410414565267 1.56474033349077e-20 hsa-miR-330-5p SOX17 -0.0582594636115701 0.896794748650637 0.0131444970555261 0.950901967500152 miRanda -0.461434964169255 9.94438298481541e-25 hsa-miR-330-5p TCF7L1 -0.0582594636115701 0.896794748650637 -0.1613283678339 0.721505802735508 miRanda -0.102635088903389 0.0450445939950442 hsa-miR-330-5p PRICKLE2 -0.0582594636115701 0.896794748650637 0.0177255412987654 0.969497997086328 miRanda;miRNATAP -0.343203715809295 2.05881181519595e-17 hsa-miR-342-3p CAMK2D -0.244092268513731 0.741215180994683 -0.130338203405614 0.785364834465144 miRanda -0.127822107335849 2.3223826328776e-06 hsa-miR-342-3p TCF7L2 -0.244092268513731 0.741215180994683 -0.151922190442888 0.739870566881007 miRanda -0.233358442684096 1.49785192802606e-18 hsa-miR-342-3p WNT10B -0.244092268513731 0.741215180994683 -0.0665077334487325 0.757196276823523 miRanda -0.184377326541959 6.55689831892104e-05 hsa-miR-342-3p WIF1 -0.244092268513731 0.741215180994683 -0.478550730412641 0.298949947494155 miRanda -0.900150959597263 1.15455195350394e-17 hsa-miR-342-3p PPARD -0.244092268513731 0.741215180994683 0.111680073842304 0.824545992844611 miRanda -0.0596297452307707 0.000187343458981037 hsa-miR-342-3p FOSL1 -0.244092268513731 0.741215180994683 -0.159042614544989 0.469785833001196 miRanda -0.403573240229472 2.83490772906014e-18 hsa-miR-326 NKD1 -0.134657725127161 0.690379143543161 -0.180903345728981 0.226242418703525 miRanda -0.0962784853850489 0.000502314332714327 hsa-miR-326 LEF1 -0.134657725127161 0.690379143543161 -0.336011475941643 0.367880485717547 miRanda -0.135291856721102 1.0203567859312e-06 hsa-miR-326 WNT5A -0.134657725127161 0.690379143543161 -0.37564066226164 0.355542462686927 miRanda -0.0640131732796636 0.0424077425920482 hsa-miR-326 FRAT2 -0.134657725127161 0.690379143543161 -0.0156891928833645 0.96774417787488 miRanda -0.0705222385650379 2.35520001443898e-06 hsa-miR-326 TCF7L1 -0.134657725127161 0.690379143543161 -0.1613283678339 0.721505802735508 miRanda -0.0596656265908928 0.0443956965937589 hsa-miR-324-5p DKK2 -0.166270923976542 0.685489008903759 0.299403293390667 0.169274319749997 miRanda -0.271141605871372 7.87002052167256e-13 hsa-miR-324-5p FZD8 -0.166270923976542 0.685489008903759 -0.078904880304417 0.834803608799275 miRanda -0.112580820578128 0.00139833151556216 hsa-miR-338-3p TCF7L2 -0.00932885158849928 0.989745642009026 -0.151922190442888 0.739870566881007 miRanda -0.164700048645429 4.65832433017924e-10 hsa-miR-338-3p PRICKLE1 -0.00932885158849928 0.989745642009026 -0.101221821514089 0.815959595958142 miRanda -0.272922631390263 3.10345977041188e-21 hsa-miR-338-3p PRKCB -0.00932885158849928 0.989745642009026 -0.253273703233256 0.375512080029025 miRanda -0.216031823790678 1.44429456470486e-06 hsa-miR-338-3p FZD7 -0.00932885158849928 0.989745642009026 -0.175347860746907 0.737019399304957 miRanda -0.141146838960966 7.12302368603286e-06 hsa-miR-339-5p WNT5B -0.119339443611091 0.808593831380581 0.0309283659862332 0.905020331050161 miRanda -0.185095344713092 5.01294231609421e-05 hsa-miR-339-5p DVL1 -0.119339443611091 0.808593831380581 -0.0106489854425629 0.983281417437041 miRanda -0.110559788670663 0.000220610270051997 hsa-miR-339-5p DAAM2 -0.119339443611091 0.808593831380581 -0.0621191173439439 0.879009045386603 miRanda -0.0900323059815056 0.0301143067500421 hsa-miR-339-5p PLCB2 -0.119339443611091 0.808593831380581 0.046924896357516 0.890573590890969 miRanda -0.0693321893033353 0.0285753970674563 hsa-miR-429 ROCK1 -0.142589289838583 0.802317907773415 -0.172548975888922 0.760861741105756 miRanda -0.107368538530982 2.74283719948915e-11 hsa-miR-429 WIF1 -0.142589289838583 0.802317907773415 -0.478550730412641 0.298949947494155 miRanda -0.57801116079909 1.92906319858818e-12 hsa-miR-429 PLCB4 -0.142589289838583 0.802317907773415 0.0386799314732373 0.922546084561183 miRanda -0.132358033926964 0.00021397529104974 hsa-miR-429 PPP3CB -0.142589289838583 0.802317907773415 0.0212980346837259 0.969289216388387 miRanda -0.0818697708421961 3.72837740995173e-14 hsa-miR-429 WNT5A -0.142589289838583 0.802317907773415 -0.37564066226164 0.355542462686927 miRanda;miRNATAP -0.0902915690326747 0.00478601162223502 hsa-miR-429 PRKCA -0.142589289838583 0.802317907773415 -0.227245147154052 0.467261641689546 miRanda;miRNATAP -0.302006017947741 7.14515269636082e-30 hsa-miR-429 AXIN2 -0.142589289838583 0.802317907773415 -0.0138759668242621 0.966117623520896 miRanda -0.190517672757253 2.55529446378965e-15 hsa-miR-429 SFRP4 -0.142589289838583 0.802317907773415 -0.0657313828955362 0.911276471082622 miRanda -0.313049201490686 1.13859376562001e-16 hsa-miR-429 FZD7 -0.142589289838583 0.802317907773415 -0.175347860746907 0.737019399304957 miRanda;miRNATAP -0.118345789299754 1.70567166199748e-06 hsa-miR-486-5p CTBP2 0.00521803679905908 0.992702666093128 -0.0161060792993091 0.978901385390853 miRanda -0.0755306715407193 1.72977666046303e-10 hsa-miR-491-5p RAC2 -0.423577120749209 0.0220584227099558 -0.0700678223375455 0.877994799861163 miRanda -0.170510866222564 9.84222871672058e-08 hsa-miR-146b-5p PPP2R5E 0.00834882458611474 0.991577009242932 -0.08594361639783 0.857732462812563 miRanda -0.108519433912314 2.38654321669596e-07 hsa-miR-146b-5p NLK 0.00834882458611474 0.991577009242932 -0.0075726819422437 0.986090753913933 miRanda -0.130772865651309 3.748420957412e-09 hsa-miR-146b-5p MAPK10 0.00834882458611474 0.991577009242932 -0.469554749724375 0.0904444026222832 miRanda -0.153060180737123 0.013695637696855 hsa-miR-146b-5p PPP2R1B 0.00834882458611474 0.991577009242932 -0.00522798350256881 0.991408260059311 miRanda -0.141184532696467 1.00140046078863e-07 hsa-miR-146b-5p GSK3B 0.00834882458611474 0.991577009242932 -0.0660851428212252 0.908304623747486 miRanda -0.0940008646706017 5.37021147359137e-07 hsa-miR-146b-5p PPP3CB 0.00834882458611474 0.991577009242932 0.0212980346837259 0.969289216388387 miRanda -0.171198371090796 2.36585494803099e-25 hsa-miR-146b-5p DAAM2 0.00834882458611474 0.991577009242932 -0.0621191173439439 0.879009045386603 miRanda -0.195815046000345 1.61868128738395e-06 hsa-miR-146b-5p DKK2 0.00834882458611474 0.991577009242932 0.299403293390667 0.169274319749997 miRanda -0.214456904219556 4.16641532867677e-06 hsa-miR-146b-5p NFAT5 0.00834882458611474 0.991577009242932 -0.140634566870934 0.80102714017311 miRanda -0.0835054010741723 0.000879978216737089 hsa-miR-455-5p PPP2R5E -0.196032525410701 0.627038966906064 -0.08594361639783 0.857732462812563 miRanda -0.1463471269634 3.89164487655405e-16 hsa-miR-455-5p MAPK10 -0.196032525410701 0.627038966906064 -0.469554749724375 0.0904444026222832 miRanda -0.2052531701295 0.000129116493384105 hsa-miR-455-5p WNT5A -0.196032525410701 0.627038966906064 -0.37564066226164 0.355542462686927 miRanda -0.0906502981718228 0.034307587471989 hsa-miR-455-5p SFRP2 -0.196032525410701 0.627038966906064 -0.000608038423459689 0.999366127714656 miRanda -0.2181929694718 1.02630459230339e-05 hsa-miR-455-5p PPP2R5C -0.196032525410701 0.627038966906064 -0.0241791959006408 0.968345143230327 miRanda -0.0569959280359623 6.33122575593458e-07 hsa-miR-455-5p DKK2 -0.196032525410701 0.627038966906064 0.299403293390667 0.169274319749997 miRanda -0.333577119442953 4.85160924554831e-17 hsa-miR-455-5p PPP2R5A -0.196032525410701 0.627038966906064 0.0837534785515848 0.890977423101542 miRanda -0.148237717752069 5.19586125294051e-14 hsa-miR-590-5p DKK2 -0.131787544750195 0.684613701486826 0.299403293390667 0.169274319749997 miRanda -0.339389607211526 1.97063715460462e-16 hsa-miR-590-5p SOX17 -0.131787544750195 0.684613701486826 0.0131444970555261 0.950901967500152 miRanda -0.386693548488825 4.68900931678905e-26 hsa-miR-590-3p TCF7L2 -0.133358268237272 0.535686159072243 -0.151922190442888 0.739870566881007 miRanda -0.121584977112315 6.35614091956812e-05 hsa-miR-590-3p SMAD3 -0.133358268237272 0.535686159072243 -0.00805727245311783 0.987902560465751 miRanda -0.163099760014662 1.73477690677951e-13 hsa-miR-590-3p MAPK10 -0.133358268237272 0.535686159072243 -0.469554749724375 0.0904444026222832 miRanda;mirMAP -0.323164263319335 2.39879463887196e-08 hsa-miR-590-3p CTNNB1 -0.133358268237272 0.535686159072243 -0.0805864772545046 0.91992258189981 miRanda -0.0696921848034279 0.000116809184455344 hsa-miR-590-3p PPP3CB -0.133358268237272 0.535686159072243 0.0212980346837259 0.969289216388387 miRanda -0.0821026738846212 2.15159070834418e-07 hsa-miR-590-3p PPP2CB -0.133358268237272 0.535686159072243 0.0839352957265156 0.884120786282379 miRanda -0.10511834935696 4.0251015210593e-09 hsa-miR-590-3p CAMK2B -0.133358268237272 0.535686159072243 0.141283778852512 0.60471522191955 miRanda -0.261169954511755 0.000193900443755323 hsa-miR-590-3p DAAM2 -0.133358268237272 0.535686159072243 -0.0621191173439439 0.879009045386603 miRanda;mirMAP -0.284734148563496 6.64083726278079e-14 hsa-miR-590-3p WNT5A -0.133358268237272 0.535686159072243 -0.37564066226164 0.355542462686927 miRanda;mirMAP;miRNATAP -0.276206250056969 2.00878373474974e-09 hsa-miR-590-3p SFRP2 -0.133358268237272 0.535686159072243 -0.000608038423459689 0.999366127714656 miRanda -0.307596222223987 8.75286794331675e-09 hsa-miR-590-3p DKK2 -0.133358268237272 0.535686159072243 0.299403293390667 0.169274319749997 miRanda;mirMAP;miRNATAP -0.294555133043718 1.22206770465475e-11 hsa-miR-590-3p FZD8 -0.133358268237272 0.535686159072243 -0.078904880304417 0.834803608799275 miRanda -0.187080083941158 3.36973671342903e-06 hsa-miR-590-3p JUN -0.133358268237272 0.535686159072243 -0.108657195258627 0.877583083771737 miRanda -0.306481168731635 1.59764946185952e-19 hsa-miR-590-3p FZD1 -0.133358268237272 0.535686159072243 -0.147165722412794 0.785892420221886 miRanda -0.073067115740317 0.00939184445779844 hsa-miR-590-3p CCND2 -0.133358268237272 0.535686159072243 -0.168931301767903 0.722558871099741 miRanda;mirMAP -0.13833737728579 9.4871454586344e-06 hsa-miR-590-3p FZD7 -0.133358268237272 0.535686159072243 -0.175347860746907 0.737019399304957 miRanda -0.113468728152917 0.0016315686222763 hsa-miR-590-3p FZD4 -0.133358268237272 0.535686159072243 0.0304707076358319 0.955399406040093 miRanda;mirMAP;miRNATAP -0.406671608133116 3.85657572987706e-27 hsa-miR-590-3p SOX17 -0.133358268237272 0.535686159072243 0.0131444970555261 0.950901967500152 miRanda;miRNATAP -0.437832269833539 1.45583399447421e-30 hsa-miR-590-3p WNT11 -0.133358268237272 0.535686159072243 0.0262086605426326 0.924129346660332 miRanda -0.293944853552164 8.66172138800842e-06 hsa-miR-542-3p PPP2R5E 0.11706603007597 0.867078497673182 -0.08594361639783 0.857732462812563 miRanda -0.14687324447004 3.28141828349973e-12 hsa-miR-542-3p NLK 0.11706603007597 0.867078497673182 -0.0075726819422437 0.986090753913933 miRanda;miRNATAP -0.0854545803576819 0.000150811859184718 hsa-miR-542-3p MAPK9 0.11706603007597 0.867078497673182 -0.00950322920821378 0.985902275586564 miRanda -0.0786543043883062 3.63350665017135e-05 hsa-miR-542-3p GSK3B 0.11706603007597 0.867078497673182 -0.0660851428212252 0.908304623747486 miRanda -0.110477181605807 5.02640445089489e-09 hsa-miR-542-3p PPP2CA 0.11706603007597 0.867078497673182 0.0284217367477391 0.96534362029265 miRanda -0.0549728706322074 0.000238114272024264 hsa-miR-542-3p CSNK1A1 0.11706603007597 0.867078497673182 -0.0165042555609478 0.982452723332151 miRanda -0.056666633619288 0.000698579234651424 hsa-miR-542-3p RHOA 0.11706603007597 0.867078497673182 0.0333557466121839 0.967744764731311 miRanda -0.0731330266454587 7.5071633424253e-09 hsa-miR-320b APC -0.0203395214664157 0.930562048282019 -0.0723635628413355 0.883189867616246 miRanda -0.0710412774343225 0.00243365863342656 hsa-miR-320b WIF1 -0.0203395214664157 0.930562048282019 -0.478550730412641 0.298949947494155 miRanda -0.250626959028316 0.0356605312110271 hsa-miR-320b NFATC4 -0.0203395214664157 0.930562048282019 0.118767632463774 0.80554796605913 miRanda;mirMAP -0.097365832827751 0.00970405659070589 hsa-miR-320b PLCB1 -0.0203395214664157 0.930562048282019 0.16954029991043 0.64744751250053 miRanda -0.120787772689584 0.0141916864456668 hsa-miR-320b PPP3CB -0.0203395214664157 0.930562048282019 0.0212980346837259 0.969289216388387 miRanda -0.0583923552164271 0.000200849550100936 hsa-miR-320b DAAM1 -0.0203395214664157 0.930562048282019 -0.0539991515887506 0.906596879539895 miRanda -0.0922843223106103 0.00413597619440288 hsa-miR-142-5p CREBBP -0.35195621065247 0.488286772825655 -0.121528460671809 0.849036225288355 mirMAP -0.0601206980638462 2.52461125214428e-06 hsa-miR-186-5p CREBBP -0.14779866926096 0.840248407765158 -0.121528460671809 0.849036225288355 mirMAP;miRNATAP -0.0667157373336062 0.00172820290135309 hsa-miR-374a-5p MAPK9 -0.0192159163584709 0.965315201402842 -0.00950322920821378 0.985902275586564 mirMAP -0.208569547789819 1.38505915980085e-14 hsa-miR-374b-5p MAPK9 -0.0341588728964348 0.947017013085837 -0.00950322920821378 0.985902275586564 mirMAP -0.162602292754305 1.32462729456077e-09 hsa-miR-1271-5p CAMK2B -0.212089092939039 0.308630501141543 0.141283778852512 0.60471522191955 mirMAP -0.199793610717617 0.000348914268332107 hsa-miR-150-5p CAMK2B -0.38061861500346 0.649699545321307 0.141283778852512 0.60471522191955 mirMAP -0.198156634053672 4.48723158474492e-06 hsa-miR-18a-5p CAMK2B -0.060215066151506 0.836155187457355 0.141283778852512 0.60471522191955 mirMAP -0.272652665944852 5.85107409807785e-08 hsa-miR-193a-3p CAMK2B -0.0143163678163178 0.969244019090322 0.141283778852512 0.60471522191955 mirMAP -0.169652643632819 0.0334097160642525 hsa-miR-2355-5p CAMK2B -0.0815180829196089 0.870082450607981 0.141283778852512 0.60471522191955 mirMAP -0.534987844428681 2.11741953815093e-09 hsa-miR-16-1-3p LRP6 -0.172993537212073 0.391863504419512 -0.261612069159627 0.621254118198097 mirMAP -0.106034973608583 0.000270497356573657 hsa-miR-181a-5p LRP6 0.0637093750406734 0.945876131429707 -0.261612069159627 0.621254118198097 mirMAP -0.121798217084118 0.000280419813406394 hsa-miR-181b-5p LRP6 0.0375130667115933 0.959555096276237 -0.261612069159627 0.621254118198097 mirMAP -0.116284631040285 3.90842230631843e-05 hsa-miR-182-5p LRP6 -0.101509746042318 0.939206381321837 -0.261612069159627 0.621254118198097 mirMAP -0.130168955655354 1.02975819358864e-08 hsa-miR-93-5p LRP6 0.0554251653547535 0.959380932710413 -0.261612069159627 0.621254118198097 mirMAP -0.0733818453269579 0.0152951601549868 hsa-miR-181a-5p CSNK2A2 0.0637093750406734 0.945876131429707 0.0688758448404903 0.868207990737335 mirMAP -0.0788009671016929 0.000533970847006194 hsa-miR-181b-5p CSNK2A2 0.0375130667115933 0.959555096276237 0.0688758448404903 0.868207990737335 mirMAP -0.0522339660832503 0.00661853793984085 hsa-miR-181c-5p CSNK2A2 -0.18121298802215 0.718350072627076 0.0688758448404903 0.868207990737335 mirMAP -0.0637677115887189 0.00109258908241335 hsa-miR-92b-3p CSNK2A2 -0.0975289498867111 0.871999313512183 0.0688758448404903 0.868207990737335 mirMAP -0.0966837728833322 1.32449620395556e-08 hsa-miR-125a-5p CAMK2A 0.00741438556537055 0.993308396064258 -0.202058295390148 0.395922649310232 mirMAP -0.306152492531801 6.24694931450318e-07 hsa-miR-19b-1-5p CAMK2A -0.126966953724701 0.619571308879527 -0.202058295390148 0.395922649310232 mirMAP -0.127806056998247 0.00655388531126769 hsa-miR-30a-5p CAMK2A -0.315304933842571 0.81611555406281 -0.202058295390148 0.395922649310232 mirMAP -0.208560410066033 1.02470554341187e-07 hsa-miR-30b-5p CAMK2A -0.126278303055191 0.871574517121767 -0.202058295390148 0.395922649310232 mirMAP -0.299993290244448 2.31458535837861e-08 hsa-miR-30c-5p CAMK2A -0.268052278300344 0.753220585849573 -0.202058295390148 0.395922649310232 mirMAP -0.343105483733946 8.04306460208188e-09 hsa-miR-30d-5p CAMK2A 0.00512174341017158 0.996390931509314 -0.202058295390148 0.395922649310232 mirMAP -0.500830199163001 3.66036488570952e-13 hsa-miR-30e-5p CAMK2A -0.183864098532103 0.86939509445488 -0.202058295390148 0.395922649310232 mirMAP -0.34551062842794 1.86639620197896e-06 hsa-miR-335-5p CAMK2A -0.0216107337976461 0.95157247156319 -0.202058295390148 0.395922649310232 mirMAP -0.159866461109795 6.97412013828671e-07 hsa-miR-361-3p CAMK2A -0.0127254134873924 0.984476698818773 -0.202058295390148 0.395922649310232 mirMAP -0.326015515432829 4.08216101266611e-05 hsa-miR-625-5p CAMK2A -0.121097781227008 0.486746151168725 -0.202058295390148 0.395922649310232 mirMAP -0.179712426290662 7.7289889783295e-05 hsa-miR-340-5p FBXW11 0.0820090452273905 0.816484190854532 0.00937498411107818 0.985997496641178 mirMAP -0.119257544627908 4.94445433521861e-11 hsa-miR-374a-5p FBXW11 -0.0192159163584709 0.965315201402842 0.00937498411107818 0.985997496641178 mirMAP -0.175519580181888 1.34257782586297e-12 hsa-miR-374b-5p FBXW11 -0.0341588728964348 0.947017013085837 0.00937498411107818 0.985997496641178 mirMAP -0.115315723202322 2.61335640229646e-06 hsa-miR-450b-5p FBXW11 0.140781738083346 0.700777724167455 0.00937498411107818 0.985997496641178 mirMAP -0.0549733508759511 0.00113504374294008 hsa-miR-590-3p FBXW11 -0.133358268237272 0.535686159072243 0.00937498411107818 0.985997496641178 mirMAP -0.0827084466226325 2.77355861423992e-07 hsa-miR-26a-5p PPP2R5C -0.0558466394626773 0.953979749143751 -0.0241791959006408 0.968345143230327 mirMAP -0.0557871071593104 0.00676239372152999 hsa-miR-148a-5p PSEN1 -0.200917166615887 0.667057353234933 -0.0685344526261558 0.908564158711858 mirMAP -0.0650483069177168 6.92356945189876e-06 hsa-miR-186-5p PSEN1 -0.14779866926096 0.840248407765158 -0.0685344526261558 0.908564158711858 mirMAP -0.0699091507220694 0.000116487998955464 hsa-miR-19b-1-5p PSEN1 -0.126966953724701 0.619571308879527 -0.0685344526261558 0.908564158711858 mirMAP -0.0950415440227374 3.86781783170165e-12 hsa-miR-125b-2-3p GSK3B -0.19521949049782 0.618072714328679 -0.0660851428212252 0.908304623747486 mirMAP -0.0760402060917948 6.89421136766207e-08 hsa-miR-132-3p GSK3B 0.0245028522614428 0.964849701708711 -0.0660851428212252 0.908304623747486 mirMAP;miRNATAP -0.0840692507849354 0.00126402975478195 hsa-miR-139-5p GSK3B 0.00543145985495741 0.991591290852214 -0.0660851428212252 0.908304623747486 mirMAP -0.0731524049083311 2.82883359148718e-08 hsa-miR-181a-5p GSK3B 0.0637093750406734 0.945876131429707 -0.0660851428212252 0.908304623747486 mirMAP -0.116539047078398 1.93667948800215e-07 hsa-miR-181b-5p GSK3B 0.0375130667115933 0.959555096276237 -0.0660851428212252 0.908304623747486 mirMAP -0.070812083097691 0.000189950214994704 hsa-miR-181c-5p GSK3B -0.18121298802215 0.718350072627076 -0.0660851428212252 0.908304623747486 mirMAP -0.0815744066070191 2.27627250349718e-05 hsa-miR-340-5p GSK3B 0.0820090452273905 0.816484190854532 -0.0660851428212252 0.908304623747486 mirMAP -0.119708017508741 1.77864671732598e-09 hsa-miR-369-3p GSK3B -0.0734607425694875 0.755351791463265 -0.0660851428212252 0.908304623747486 mirMAP;miRNATAP -0.0637073795762724 0.000298128037012676 hsa-miR-374a-5p GSK3B -0.0192159163584709 0.965315201402842 -0.0660851428212252 0.908304623747486 mirMAP -0.161835653986741 2.7137832607523e-09 hsa-miR-374b-5p GSK3B -0.0341588728964348 0.947017013085837 -0.0660851428212252 0.908304623747486 mirMAP -0.0796497803434764 0.00313181481988245 hsa-miR-195-3p NLK -0.0314657373015459 0.893921960533907 -0.0075726819422437 0.986090753913933 mirMAP -0.145388282098103 3.0064135076299e-11 hsa-miR-181a-5p DAAM1 0.0637093750406734 0.945876131429707 -0.0539991515887506 0.906596879539895 mirMAP -0.320622611303431 3.63286030739205e-15 hsa-miR-181b-5p DAAM1 0.0375130667115933 0.959555096276237 -0.0539991515887506 0.906596879539895 mirMAP -0.297706446427752 3.7202331187859e-18 hsa-miR-181c-5p DAAM1 -0.18121298802215 0.718350072627076 -0.0539991515887506 0.906596879539895 mirMAP -0.250470942223665 9.24701348872529e-13 hsa-miR-130b-5p NFATC4 -0.24592404944858 0.439156866715699 0.118767632463774 0.80554796605913 mirMAP -0.273306003041798 2.37279973423709e-19 hsa-miR-361-3p NFATC4 -0.0127254134873924 0.984476698818773 0.118767632463774 0.80554796605913 mirMAP -0.221299437804629 0.000469274259610322 hsa-miR-150-5p NFATC4 -0.38061861500346 0.649699545321307 0.118767632463774 0.80554796605913 mirMAP -0.127353989190525 5.08033729715864e-08 hsa-miR-15b-3p NFATC4 -0.126451993800397 0.773147230209712 0.118767632463774 0.80554796605913 mirMAP -0.238062507407611 4.12345167097552e-14 hsa-miR-181a-2-3p NFATC4 -0.129301605775352 0.87844748146472 0.118767632463774 0.80554796605913 mirMAP -0.265900817473076 5.67846111588394e-07 hsa-miR-532-5p NFATC4 0.0193679288578856 0.981424049788362 0.118767632463774 0.80554796605913 mirMAP -0.351153097111496 2.13922805026231e-12 hsa-miR-629-3p NFATC4 -0.203962319893151 0.416043359122368 0.118767632463774 0.80554796605913 mirMAP -0.222553384296637 1.10177313904365e-14 hsa-miR-182-5p NFATC2 -0.101509746042318 0.939206381321837 -0.38368313501719 0.1310673127204 mirMAP -0.319993630027942 3.80744800734882e-10 hsa-miR-19a-3p NFATC2 -0.00951638786771092 0.980991306004163 -0.38368313501719 0.1310673127204 mirMAP -0.325063324024532 3.38278468154619e-11 hsa-miR-19b-3p NFATC2 -0.0314903804749491 0.95913844863355 -0.38368313501719 0.1310673127204 mirMAP -0.287342497987003 2.05092326956767e-06 hsa-miR-200b-5p NFATC2 -0.352571850823225 0.348654599385815 -0.38368313501719 0.1310673127204 mirMAP -0.148120269747522 0.0033400668976821 hsa-miR-3613-5p NFATC2 -0.255417595166074 0.404939118148321 -0.38368313501719 0.1310673127204 mirMAP -0.344189531636949 1.85303094879685e-08 hsa-miR-590-3p NFATC2 -0.133358268237272 0.535686159072243 -0.38368313501719 0.1310673127204 mirMAP -0.207787840865524 0.000469613853353843 hsa-miR-26a-5p CSNK2A1 -0.0558466394626773 0.953979749143751 0.0222385179144631 0.968143761360086 mirMAP -0.183032285298427 3.80367876396133e-11 hsa-let-7a-3p PLCB4 -0.130729276906521 0.779692030572974 0.0386799314732373 0.922546084561183 mirMAP;miRNATAP -0.19467309283188 0.00578258252733417 hsa-miR-22-5p TBL1X -0.282351613070713 0.500015990730185 0.060219580834767 0.90746646150957 mirMAP -0.113674770615703 1.28737390658952e-05 hsa-miR-584-5p TBL1X -0.118725130378714 0.812527158213821 0.060219580834767 0.90746646150957 mirMAP -0.0649135654890803 0.000965392741324838 hsa-miR-141-3p NFAT5 -0.179420502124191 0.83354105481228 -0.140634566870934 0.80102714017311 mirMAP -0.149337877858226 6.05474618072504e-20 hsa-miR-148a-5p NFAT5 -0.200917166615887 0.667057353234933 -0.140634566870934 0.80102714017311 mirMAP -0.0959423665755262 7.49604236972089e-05 hsa-miR-155-5p NFAT5 -0.167418736137707 0.822294484498835 -0.140634566870934 0.80102714017311 mirMAP;miRNATAP -0.100566120170304 1.0444676030806e-06 hsa-miR-15b-3p NFAT5 -0.126451993800397 0.773147230209712 -0.140634566870934 0.80102714017311 mirMAP -0.0892717221333543 6.11903719735818e-06 hsa-miR-16-1-3p NFAT5 -0.172993537212073 0.391863504419512 -0.140634566870934 0.80102714017311 mirMAP -0.204713975377917 1.41977903192804e-15 hsa-miR-17-3p NFAT5 -0.00462206849027691 0.994608252674318 -0.140634566870934 0.80102714017311 mirMAP -0.129870741981494 1.53941711137671e-07 hsa-miR-200a-3p NFAT5 -0.192839143060886 0.77994979695622 -0.140634566870934 0.80102714017311 mirMAP -0.120533278835972 8.59748977733914e-14 hsa-miR-362-5p NFAT5 0.215268517371166 0.469421708227034 -0.140634566870934 0.80102714017311 mirMAP -0.0529773799507227 0.0128378424120252 hsa-miR-374a-3p NFAT5 -0.0781632437076389 0.926379383884834 -0.140634566870934 0.80102714017311 mirMAP -0.114187577439033 0.00184299941974274 hsa-miR-708-3p NFAT5 -0.0786820348913011 0.88886515820271 -0.140634566870934 0.80102714017311 mirMAP -0.0579983451885995 0.0264442707132684 hsa-miR-143-3p FZD3 0.0939643084482285 0.945738813861442 -0.0249834874630155 0.930139178962665 mirMAP -0.0943897446898744 0.0131325727397996 hsa-miR-16-2-3p FZD3 -0.107555719075227 0.702302679752719 -0.0249834874630155 0.930139178962665 mirMAP -0.131652726734944 0.000136576830732616 hsa-miR-195-3p FZD3 -0.0314657373015459 0.893921960533907 -0.0249834874630155 0.930139178962665 mirMAP -0.0827789971463574 0.0260962439928842 hsa-miR-374a-5p FZD3 -0.0192159163584709 0.965315201402842 -0.0249834874630155 0.930139178962665 mirMAP -0.182913725946331 0.00081843481388181 hsa-miR-374b-5p FZD3 -0.0341588728964348 0.947017013085837 -0.0249834874630155 0.930139178962665 mirMAP -0.120532507815516 0.025152765687485 hsa-miR-452-5p FZD3 -0.0590392811106577 0.906930362717493 -0.0249834874630155 0.930139178962665 mirMAP -0.0715021985555609 0.00049173617962286 hsa-miR-182-5p SFRP1 -0.101509746042318 0.939206381321837 -0.472006437969406 0.460625213922239 mirMAP -0.967266087949178 4.26592739938163e-34 hsa-miR-96-5p SFRP1 -0.153312892459014 0.726115467443483 -0.472006437969406 0.460625213922239 mirMAP -0.844516363711542 6.21667681893678e-38 hsa-miR-335-3p WNT2 0.248840023734261 0.661533599343062 -0.0704278884095242 0.817871130365495 mirMAP -0.124921231734074 0.0013759064532322 hsa-miR-22-5p MAPK8 -0.282351613070713 0.500015990730185 -0.267537090166021 0.457115846208038 mirMAP -0.111645018994966 0.000421521825972328 hsa-miR-374a-3p MAPK8 -0.0781632437076389 0.926379383884834 -0.267537090166021 0.457115846208038 mirMAP -0.109853677099594 0.0151429921091769 hsa-miR-381-3p MAPK8 -0.0215856799485721 0.961260144775191 -0.267537090166021 0.457115846208038 mirMAP -0.0757300155871171 0.00607185426136617 hsa-miR-708-3p MAPK8 -0.0786820348913011 0.88886515820271 -0.267537090166021 0.457115846208038 mirMAP -0.0776963881176719 0.0157848673073817 hsa-miR-576-5p WNT3 -0.111163544190811 0.739840245445557 -0.0153912479566303 0.926692523100822 mirMAP -0.138865149881875 0.0032152515286964 hsa-miR-589-3p WNT3 -0.0679748049633819 0.703146664597157 -0.0153912479566303 0.926692523100822 mirMAP -0.105204288945704 0.00433518385741643 hsa-miR-30d-3p MAPK10 0.010689376681901 0.963707546423024 -0.469554749724375 0.0904444026222832 mirMAP -0.192664485965265 0.00899807954985931 hsa-miR-150-5p CCND1 -0.38061861500346 0.649699545321307 0.0138594286077627 0.985644356886489 mirMAP -0.187252742453937 1.34917625164856e-11 22025269 Consistent with the outcome of cell cycle arrest and cell apoptosis Western blotting results demonstrate that the cell cycle regulator cyclin D1 and cell survival regulator Bcl-2 are decreased in cells transfected with miR-150 worse survival; liver cancer hsa-miR-186-5p CCND1 -0.14779866926096 0.840248407765158 0.0138594286077627 0.985644356886489 mirMAP -0.494988902443749 5.18517439622754e-18 23204228 Cyclin D1 CCND1 cyclin-dependent kinase CDK2 and CDK6 were each directly targeted for inhibition by miR-186 and restoring their expression reversed miR-186-mediated inhibition of cell-cycle progression progression; lung cancer hsa-miR-29a-3p CCND1 -0.173904473376583 0.873886834369773 0.0138594286077627 0.985644356886489 mirMAP -0.358623457755512 1.12263469726765e-09 hsa-miR-340-5p CCND1 0.0820090452273905 0.816484190854532 0.0138594286077627 0.985644356886489 mirMAP -0.157803294541288 0.00210629660665075 25817794;25817794 miR-340 inhibits glioblastoma cell proliferation by suppressing CDK6 cyclin-D1 and cyclin-D2;Confirming these results we found that re-introducing CDK6 cyclin-D1 or cyclin-D2 expression partially but significantly rescues cells from the suppression of cell proliferation and cell cycle arrest mediated by miR-340 ; glioblastoma;glioblastoma hsa-miR-590-3p CCND1 -0.133358268237272 0.535686159072243 0.0138594286077627 0.985644356886489 mirMAP -0.221641713536578 8.94498108920728e-07 hsa-miR-195-5p PPARD -0.00971531160236339 0.98418421453416 0.111680073842304 0.824545992844611 mirMAP -0.0942321743291273 4.91503402462825e-07 hsa-miR-497-5p PPARD -0.149621539826846 0.732358272818906 0.111680073842304 0.824545992844611 mirMAP -0.108496813581842 2.57101128829637e-09 hsa-miR-186-5p PPP2CA -0.14779866926096 0.840248407765158 0.0284217367477391 0.96534362029265 mirMAP -0.0616775576387173 0.000579102189201237 hsa-miR-30e-5p PPP2CA -0.183864098532103 0.86939509445488 0.0284217367477391 0.96534362029265 mirMAP -0.0857929019748377 4.87885777798762e-05 hsa-miR-495-3p PPP2CA -0.159204559213757 0.555240058524588 0.0284217367477391 0.96534362029265 mirMAP -0.066863932380668 3.58715604589208e-08 hsa-miR-142-5p CSNK1A1 -0.35195621065247 0.488286772825655 -0.0165042555609478 0.982452723332151 mirMAP -0.0892234744646103 6.3600215364229e-14 hsa-miR-19a-3p CSNK1A1 -0.00951638786771092 0.980991306004163 -0.0165042555609478 0.982452723332151 mirMAP -0.108764735747862 1.2137097303677e-17 hsa-miR-19b-3p CSNK1A1 -0.0314903804749491 0.95913844863355 -0.0165042555609478 0.982452723332151 mirMAP -0.113820613941943 4.04480731084776e-13 hsa-miR-20a-3p CSNK1A1 -0.267112043185936 0.342386318550293 -0.0165042555609478 0.982452723332151 mirMAP -0.0578747308034147 1.10534857487397e-06 hsa-miR-29a-5p CSNK1A1 -0.242897712652954 0.339681975959217 -0.0165042555609478 0.982452723332151 mirMAP -0.0586005056839863 0.000400694006092211 hsa-miR-320b CSNK1A1 -0.0203395214664157 0.930562048282019 -0.0165042555609478 0.982452723332151 mirMAP -0.0543914554208678 0.000396999491173952 hsa-miR-340-5p CSNK1A1 0.0820090452273905 0.816484190854532 -0.0165042555609478 0.982452723332151 mirMAP -0.0684667642235698 9.92603696319072e-05 hsa-miR-576-5p CSNK1A1 -0.111163544190811 0.739840245445557 -0.0165042555609478 0.982452723332151 mirMAP -0.103328281253168 1.20036851836147e-10 hsa-miR-590-3p CSNK1A1 -0.133358268237272 0.535686159072243 -0.0165042555609478 0.982452723332151 mirMAP -0.0554766447162981 0.000356679549352052 hsa-miR-126-5p WNT5A -0.0509133532389665 0.941546676673956 -0.37564066226164 0.355542462686927 mirMAP -0.121538798785954 0.015283230436261 hsa-miR-144-5p WNT5A 0.0295121751859417 0.95436780391301 -0.37564066226164 0.355542462686927 mirMAP -0.108189974261664 0.000232182868580216 hsa-miR-15b-3p WNT5A -0.126451993800397 0.773147230209712 -0.37564066226164 0.355542462686927 mirMAP -0.282465371884018 2.03011972026487e-13 hsa-miR-26b-5p WNT5A -0.165683456923659 0.842739329770527 -0.37564066226164 0.355542462686927 mirMAP;miRNATAP -0.128410741477027 0.0339630309215917 hsa-miR-29a-5p WNT5A -0.242897712652954 0.339681975959217 -0.37564066226164 0.355542462686927 mirMAP -0.173390051712273 0.000449511750498096 hsa-miR-30b-5p WNT5A -0.126278303055191 0.871574517121767 -0.37564066226164 0.355542462686927 mirMAP -0.221268990849156 2.30222342732902e-05 hsa-miR-30c-5p WNT5A -0.268052278300344 0.753220585849573 -0.37564066226164 0.355542462686927 mirMAP -0.153444255475845 0.00829557687465555 hsa-miR-30d-3p WNT5A 0.010689376681901 0.963707546423024 -0.37564066226164 0.355542462686927 mirMAP -0.328486161205366 1.77036516167105e-08 hsa-miR-30d-5p WNT5A 0.00512174341017158 0.996390931509314 -0.37564066226164 0.355542462686927 mirMAP -0.395918928140374 3.76530346593888e-09 hsa-miR-30e-5p WNT5A -0.183864098532103 0.86939509445488 -0.37564066226164 0.355542462686927 mirMAP -0.355937424695316 3.98104999357833e-07 hsa-miR-576-5p WNT5A -0.111163544190811 0.739840245445557 -0.37564066226164 0.355542462686927 mirMAP -0.219900857430154 5.01514505641987e-06 hsa-miR-7-1-3p WNT5A -0.0332815306858167 0.935725386085843 -0.37564066226164 0.355542462686927 mirMAP -0.228321533184529 2.31205663077237e-07 hsa-miR-125a-5p APC2 0.00741438556537055 0.993308396064258 0.0186802292224786 0.928284580845751 mirMAP -0.15416857175893 0.00430379284665603 hsa-miR-125b-5p APC2 -0.0598851546678105 0.945288350565791 0.0186802292224786 0.928284580845751 mirMAP -0.2419595151452 1.3692162649798e-09 hsa-miR-20a-3p APC2 -0.267112043185936 0.342386318550293 0.0186802292224786 0.928284580845751 mirMAP -0.138852827654145 1.45583029063542e-05 hsa-miR-2355-5p APC2 -0.0815180829196089 0.870082450607981 0.0186802292224786 0.928284580845751 mirMAP -0.186684220875449 0.000506491734344051 hsa-miR-27a-5p APC2 -0.212495661304867 0.555626332542093 0.0186802292224786 0.928284580845751 mirMAP -0.0997086176405074 0.00773982123674548 hsa-miR-28-5p APC2 -0.212713060051394 0.714914931441106 0.0186802292224786 0.928284580845751 mirMAP -0.274501081998138 0.000152045555835454 hsa-miR-345-5p APC2 -0.318796500689201 0.40673094545688 0.0186802292224786 0.928284580845751 mirMAP -0.110916549318979 0.000360181957971393 hsa-miR-505-5p APC2 -0.119032738073989 0.680147623619206 0.0186802292224786 0.928284580845751 mirMAP -0.173610865295371 1.44750832015884e-06 hsa-miR-195-3p CACYBP -0.0314657373015459 0.893921960533907 0.135598682500361 0.816402229143505 mirMAP -0.232768845045075 1.84734186920475e-28 hsa-let-7a-3p CCND2 -0.130729276906521 0.779692030572974 -0.168931301767903 0.722558871099741 mirMAP -0.215275364862757 3.63993039775257e-07 hsa-miR-130b-5p CCND2 -0.24592404944858 0.439156866715699 -0.168931301767903 0.722558871099741 mirMAP -0.113060251982174 8.9777676148938e-06 hsa-miR-151a-3p CCND2 0.0540261749026669 0.955985797011372 -0.168931301767903 0.722558871099741 mirMAP -0.17767569994557 0.000108302525662849 hsa-miR-16-2-3p CCND2 -0.107555719075227 0.702302679752719 -0.168931301767903 0.722558871099741 mirMAP -0.088691651260492 0.00384607210090869 hsa-miR-21-3p CCND2 -0.103229815917794 0.915406989389524 -0.168931301767903 0.722558871099741 mirMAP -0.127404398971718 2.08059143790106e-05 hsa-miR-30d-3p CCND2 0.010689376681901 0.963707546423024 -0.168931301767903 0.722558871099741 mirMAP -0.277305057640272 1.40644960106378e-12 hsa-miR-320b CCND2 -0.0203395214664157 0.930562048282019 -0.168931301767903 0.722558871099741 mirMAP;miRNATAP -0.105338094438455 0.000662995774848357 hsa-miR-500a-5p CCND2 0.0097790305601746 0.958449089566593 -0.168931301767903 0.722558871099741 mirMAP -0.0659652416737068 0.0253797937742454 hsa-miR-590-5p CCND2 -0.131787544750195 0.684613701486826 -0.168931301767903 0.722558871099741 mirMAP -0.151134124586935 3.93710909950627e-07 hsa-miR-660-5p CCND2 0.0681681272574144 0.880554662781555 -0.168931301767903 0.722558871099741 mirMAP -0.106401121539045 0.00339848496849202 hsa-miR-7-1-3p CCND2 -0.0332815306858167 0.935725386085843 -0.168931301767903 0.722558871099741 mirMAP -0.138929082076826 3.22847149980611e-06 hsa-miR-340-5p ROCK2 0.0820090452273905 0.816484190854532 -0.273205140377062 0.589812182930179 mirMAP -0.395127263389571 3.35868529258436e-20 hsa-miR-500a-5p ROCK2 0.0097790305601746 0.958449089566593 -0.273205140377062 0.589812182930179 mirMAP -0.0888322645165881 0.014849575176026 hsa-miR-142-5p APC -0.35195621065247 0.488286772825655 -0.0723635628413355 0.883189867616246 mirMAP -0.093329003143689 3.38719239126681e-07 hsa-miR-374a-5p APC -0.0192159163584709 0.965315201402842 -0.0723635628413355 0.883189867616246 mirMAP -0.183579142691311 5.11997182923449e-07 hsa-miR-374b-5p APC -0.0341588728964348 0.947017013085837 -0.0723635628413355 0.883189867616246 mirMAP -0.0937418019732998 0.00948049600047555 hsa-miR-664a-3p WNT10A 0.0260321839026805 0.956434140422838 -0.0272502077269408 0.897730347620335 mirMAP -0.421214281367344 2.22889192706043e-09 hsa-miR-30d-3p PPP2R1B 0.010689376681901 0.963707546423024 -0.00522798350256881 0.991408260059311 mirMAP -0.157184793756038 6.17261426855798e-07 hsa-miR-335-3p LEF1 0.248840023734261 0.661533599343062 -0.336011475941643 0.367880485717547 mirMAP -0.25656991808437 2.69608203703196e-17 hsa-miR-340-5p PPP3CA 0.0820090452273905 0.816484190854532 -0.078895894384611 0.886413963353503 mirMAP -0.176067551771713 1.43168876315375e-09 hsa-miR-30b-5p PRICKLE1 -0.126278303055191 0.871574517121767 -0.101221821514089 0.815959595958142 mirMAP -0.181028075048876 1.82963092033562e-06 hsa-miR-330-3p PRICKLE1 -0.00366157141494194 0.98416704678615 -0.101221821514089 0.815959595958142 mirMAP;miRNATAP -0.0693218310221447 0.0466781759615814 hsa-miR-106b-5p SMAD4 -0.0853499657102335 0.901700669947609 -0.0337260829637342 0.952673159973339 mirMAP;miRNATAP -0.132593131707842 2.60050027244317e-11 hsa-miR-141-3p SMAD4 -0.179420502124191 0.83354105481228 -0.0337260829637342 0.952673159973339 mirMAP -0.0665975031901977 4.1529973534957e-08 hsa-miR-142-5p SMAD4 -0.35195621065247 0.488286772825655 -0.0337260829637342 0.952673159973339 mirMAP -0.0749392072235979 1.78270524234105e-08 24895601 We identified three significantly associated mRNA-miRNA pairs: BCL2 was positively associated with miR-16 and SMAD4 was positively associated with miR-567 in the CRC tissue while MSH6 was positively associated with miR-142-5p in the normal tissue colorectal cancer hsa-miR-21-3p SMAD4 -0.103229815917794 0.915406989389524 -0.0337260829637342 0.952673159973339 mirMAP -0.142251679213528 1.79438322002583e-18 hsa-miR-32-5p SMAD4 -0.218686304292785 0.59094441655546 -0.0337260829637342 0.952673159973339 mirMAP -0.104053876543456 9.38449586813502e-09 hsa-miR-361-5p SMAD4 0.0775639231585332 0.909963521897996 -0.0337260829637342 0.952673159973339 mirMAP -0.13420862344236 0.000247319809078657 hsa-miR-369-3p SMAD4 -0.0734607425694875 0.755351791463265 -0.0337260829637342 0.952673159973339 mirMAP -0.0973232440468371 1.2339805788712e-08 hsa-miR-374a-5p SMAD4 -0.0192159163584709 0.965315201402842 -0.0337260829637342 0.952673159973339 mirMAP -0.0886712779160249 0.000913277124464415 hsa-miR-425-5p SMAD4 -0.179935054542016 0.805737521016457 -0.0337260829637342 0.952673159973339 mirMAP -0.0740108843152013 4.03711017781556e-06 hsa-miR-450b-5p SMAD4 0.140781738083346 0.700777724167455 -0.0337260829637342 0.952673159973339 mirMAP -0.087654088132823 1.06441835046281e-06 hsa-miR-493-5p SMAD4 -0.284749337378863 0.305440922291611 -0.0337260829637342 0.952673159973339 mirMAP -0.0692877234531395 2.7044003988377e-06 hsa-miR-500a-5p SMAD4 0.0097790305601746 0.958449089566593 -0.0337260829637342 0.952673159973339 mirMAP -0.0875827332136534 5.86614466503988e-08 hsa-miR-92b-3p SMAD4 -0.0975289498867111 0.871999313512183 -0.0337260829637342 0.952673159973339 mirMAP -0.0553219412443082 0.000805310824352674 hsa-miR-16-2-3p PRKACB -0.107555719075227 0.702302679752719 -0.0742837105484302 0.886731753016865 mirMAP -0.0941100915668049 0.0219233623396869 hsa-miR-30d-3p PRKACB 0.010689376681901 0.963707546423024 -0.0742837105484302 0.886731753016865 mirMAP -0.251818481172515 1.82407867076559e-06 hsa-miR-340-5p PRKACB 0.0820090452273905 0.816484190854532 -0.0742837105484302 0.886731753016865 mirMAP -0.151842813986032 0.001373090709035 hsa-let-7a-3p WNT9A -0.130729276906521 0.779692030572974 -0.0458266531912801 0.800227025121973 mirMAP -0.134171267872056 0.0451424441710751 hsa-miR-1271-5p WNT9A -0.212089092939039 0.308630501141543 -0.0458266531912801 0.800227025121973 mirMAP -0.151077426632908 0.000116310190119482 hsa-miR-148a-3p WNT9A -0.184595009730559 0.892714155682155 -0.0458266531912801 0.800227025121973 mirMAP -0.298084226700717 2.38424942045375e-09 hsa-miR-148b-3p WNT9A -0.121415535518017 0.85232232285121 -0.0458266531912801 0.800227025121973 mirMAP -0.216690484061052 0.000659770444792974 hsa-miR-15b-5p WNT9A 0.0382341477298391 0.953925647243518 -0.0458266531912801 0.800227025121973 mirMAP -0.160780744423949 0.00213391068310254 hsa-miR-16-5p WNT9A -0.131938295863899 0.869419037928521 -0.0458266531912801 0.800227025121973 mirMAP -0.294351524109689 2.19404233093207e-06 hsa-miR-181a-2-3p WNT9A -0.129301605775352 0.87844748146472 -0.0458266531912801 0.800227025121973 mirMAP -0.200099377422022 0.00380063581033883 hsa-miR-193a-3p WNT9A -0.0143163678163178 0.969244019090322 -0.0458266531912801 0.800227025121973 mirMAP -0.305391600401298 3.90157370096497e-08 hsa-miR-195-5p WNT9A -0.00971531160236339 0.98418421453416 -0.0458266531912801 0.800227025121973 mirMAP -0.196363300820022 0.000137496059895827 hsa-miR-28-5p WNT9A -0.212713060051394 0.714914931441106 -0.0458266531912801 0.800227025121973 mirMAP -0.292797790744078 0.000600350405048975 hsa-miR-32-5p WNT9A -0.218686304292785 0.59094441655546 -0.0458266531912801 0.800227025121973 mirMAP -0.216445530743276 3.06978747423399e-05 hsa-miR-331-3p WNT9A -0.235461895487326 0.594749794653888 -0.0458266531912801 0.800227025121973 mirMAP -0.137832471681534 0.00151040501960236 hsa-miR-363-3p WNT9A -0.390568500537594 0.251677192180883 -0.0458266531912801 0.800227025121973 mirMAP -0.126772985407334 8.48022074883423e-05 hsa-miR-424-5p WNT9A -0.0714822550667202 0.907577243491088 -0.0458266531912801 0.800227025121973 mirMAP -0.203387678407749 6.84865574984046e-07 hsa-miR-497-5p WNT9A -0.149621539826846 0.732358272818906 -0.0458266531912801 0.800227025121973 mirMAP -0.228181412286226 5.31377710156938e-06 hsa-miR-532-3p WNT9A -0.247223762437475 0.58134232021997 -0.0458266531912801 0.800227025121973 mirMAP -0.144881932218838 0.000552241596034881 hsa-miR-708-5p WNT9A -0.180929524949216 0.695247413572264 -0.0458266531912801 0.800227025121973 mirMAP -0.12045189873946 0.00968711444884768 hsa-miR-29b-2-5p CAMK2D -0.0126563776248076 0.980563872976574 -0.130338203405614 0.785364834465144 mirMAP -0.0862167037666596 0.00375607342828912 hsa-miR-429 CAMK2D -0.142589289838583 0.802317907773415 -0.130338203405614 0.785364834465144 mirMAP;miRNATAP -0.142005527474459 9.28571715889098e-12 hsa-miR-141-5p DAAM2 -0.21874832932521 0.789341690802864 -0.0621191173439439 0.879009045386603 mirMAP -0.38681514285257 1.29341814943135e-41 hsa-miR-182-5p DAAM2 -0.101509746042318 0.939206381321837 -0.0621191173439439 0.879009045386603 mirMAP -0.428502281083267 1.77522555258754e-41 hsa-miR-195-3p PPP2R5E -0.0314657373015459 0.893921960533907 -0.08594361639783 0.857732462812563 mirMAP -0.0621263181485164 0.002925460505507 hsa-miR-30a-5p PPP2R5E -0.315304933842571 0.81611555406281 -0.08594361639783 0.857732462812563 mirMAP -0.0676714390463409 3.26376292912124e-05 hsa-miR-30d-5p PPP2R5E 0.00512174341017158 0.996390931509314 -0.08594361639783 0.857732462812563 mirMAP -0.0884260523186253 0.00223227523371305 hsa-miR-374a-5p PPP2R5E -0.0192159163584709 0.965315201402842 -0.08594361639783 0.857732462812563 mirMAP -0.175200740577251 9.34615884892216e-09 hsa-miR-181b-5p PRKCA 0.0375130667115933 0.959555096276237 -0.227245147154052 0.467261641689546 mirMAP -0.11742885805708 0.0062191009662321 hsa-miR-181c-5p PRKCA -0.18121298802215 0.718350072627076 -0.227245147154052 0.467261641689546 mirMAP -0.151937361609795 0.00048559417186175 hsa-miR-194-5p PRKCA -0.0985657553098873 0.88041455080541 -0.227245147154052 0.467261641689546 mirMAP -0.194734764385864 0.000579018161354159 hsa-miR-29b-2-5p PRKCA -0.0126563776248076 0.980563872976574 -0.227245147154052 0.467261641689546 mirMAP -0.365220324605892 6.60788568306249e-22 hsa-miR-30d-3p PRKCA 0.010689376681901 0.963707546423024 -0.227245147154052 0.467261641689546 mirMAP -0.185045137833304 0.000246654172160224 hsa-miR-339-5p PRKCA -0.119339443611091 0.808593831380581 -0.227245147154052 0.467261641689546 mirMAP -0.116903398908303 0.00661066095178211 hsa-miR-340-5p PRKCA 0.0820090452273905 0.816484190854532 -0.227245147154052 0.467261641689546 mirMAP -0.157880969288124 0.000482930053726641 hsa-miR-3607-3p PRKCA -0.410705558355355 0.442005238257379 -0.227245147154052 0.467261641689546 mirMAP -0.0500115227779554 0.0458610850060818 hsa-miR-93-3p PRKCA -0.211485740452515 0.540427728229387 -0.227245147154052 0.467261641689546 mirMAP -0.0982678468043941 0.00733243041620444 hsa-miR-331-3p WNT3A -0.235461895487326 0.594749794653888 0.492064690202575 0.228807004551161 mirMAP -0.186748490696253 0.00116808678187749 hsa-miR-335-5p WNT3A -0.0216107337976461 0.95157247156319 0.492064690202575 0.228807004551161 mirMAP -0.144104496367168 0.00107984254818266 hsa-miR-576-5p DKK2 -0.111163544190811 0.739840245445557 0.299403293390667 0.169274319749997 mirMAP -0.200655010439433 1.08911792496519e-05 hsa-miR-330-3p FZD7 -0.00366157141494194 0.98416704678615 -0.175347860746907 0.737019399304957 mirMAP -0.0755364376249935 0.042324721349332 hsa-miR-29b-3p FZD1 -0.147629200668355 0.855068431567557 -0.147165722412794 0.785892420221886 mirMAP -0.142292816540562 7.62954986745634e-06 hsa-miR-29c-3p FZD1 -0.0526710652467877 0.956320854458284 -0.147165722412794 0.785892420221886 mirMAP -0.218168403933287 1.2823801399907e-12 hsa-miR-1271-5p CTBP1 -0.212089092939039 0.308630501141543 -0.00426146109334713 0.994460970584857 mirMAP -0.118815949476465 5.57969791453083e-21 hsa-miR-148a-3p CTBP1 -0.184595009730559 0.892714155682155 -0.00426146109334713 0.994460970584857 mirMAP -0.061008054084309 0.000230144807012282 hsa-miR-181a-2-3p CTBP1 -0.129301605775352 0.87844748146472 -0.00426146109334713 0.994460970584857 mirMAP -0.0725057668985632 0.0014516660911181 hsa-miR-2355-5p CTBP1 -0.0815180829196089 0.870082450607981 -0.00426146109334713 0.994460970584857 mirMAP -0.0889602174144925 1.8521801249275e-05 hsa-miR-326 CTBP1 -0.134657725127161 0.690379143543161 -0.00426146109334713 0.994460970584857 mirMAP -0.0981289932387495 8.75177902965331e-20 hsa-miR-582-3p CTBP1 -0.271950211685077 0.661504921479239 -0.00426146109334713 0.994460970584857 mirMAP -0.0655226010143664 2.45415346482035e-05 hsa-miR-589-3p CTBP1 -0.0679748049633819 0.703146664597157 -0.00426146109334713 0.994460970584857 mirMAP -0.0614544559637323 3.11904526528367e-06 hsa-miR-143-3p DVL3 0.0939643084482285 0.945738813861442 0.00975763465514845 0.987406911304736 mirMAP -0.0685330198147563 1.621221438522e-06 hsa-miR-30d-5p VANGL2 0.00512174341017158 0.996390931509314 -0.491521821831935 0.31936517526481 mirMAP -0.180745549789828 0.0270109717918775 hsa-miR-589-5p VANGL2 -0.0214815940746442 0.967157138449855 -0.491521821831935 0.31936517526481 mirMAP -0.202426378713681 0.0137114280708807 hsa-miR-7-1-3p VANGL2 -0.0332815306858167 0.935725386085843 -0.491521821831935 0.31936517526481 mirMAP -0.142492068299119 0.00779650628148012 hsa-miR-200a-3p FZD5 -0.192839143060886 0.77994979695622 -0.186395173219289 0.518902590417545 mirMAP -0.193303591193815 3.54560151752924e-19 hsa-miR-30d-3p FZD5 0.010689376681901 0.963707546423024 -0.186395173219289 0.518902590417545 mirMAP -0.0978871424368001 0.0149498072414181 hsa-miR-450b-5p FZD5 0.140781738083346 0.700777724167455 -0.186395173219289 0.518902590417545 mirMAP -0.162494214108962 8.75558752610779e-07 hsa-miR-493-5p FZD5 -0.284749337378863 0.305440922291611 -0.186395173219289 0.518902590417545 mirMAP -0.148378073973601 4.37435544088392e-08 hsa-let-7a-3p PRICKLE2 -0.130729276906521 0.779692030572974 0.0177255412987654 0.969497997086328 mirMAP -0.246014128854383 2.22205350393919e-07 hsa-let-7f-1-3p PRICKLE2 -0.222769653030984 0.176243975299018 0.0177255412987654 0.969497997086328 mirMAP -0.188710377572271 4.19141267701058e-07 hsa-miR-130b-5p PRICKLE2 -0.24592404944858 0.439156866715699 0.0177255412987654 0.969497997086328 mirMAP -0.285840335314836 1.14671532560812e-24 hsa-miR-146a-5p PRICKLE2 -0.362125606043493 0.545323292976414 0.0177255412987654 0.969497997086328 mirMAP -0.22636521497307 1.32581685728342e-14 hsa-miR-148a-5p PRICKLE2 -0.200917166615887 0.667057353234933 0.0177255412987654 0.969497997086328 mirMAP -0.225124369392631 3.42801988361129e-10 hsa-miR-15b-3p PRICKLE2 -0.126451993800397 0.773147230209712 0.0177255412987654 0.969497997086328 mirMAP -0.350402182346711 3.40989651980756e-35 hsa-miR-16-2-3p PRICKLE2 -0.107555719075227 0.702302679752719 0.0177255412987654 0.969497997086328 mirMAP -0.331538116676408 5.09067457660196e-23 hsa-miR-181a-5p PRICKLE2 0.0637093750406734 0.945876131429707 0.0177255412987654 0.969497997086328 mirMAP;miRNATAP -0.249054061695165 2.07379976240012e-08 hsa-miR-181b-5p PRICKLE2 0.0375130667115933 0.959555096276237 0.0177255412987654 0.969497997086328 mirMAP;miRNATAP -0.32240643127462 3.08135600536136e-18 hsa-miR-181c-5p PRICKLE2 -0.18121298802215 0.718350072627076 0.0177255412987654 0.969497997086328 mirMAP;miRNATAP -0.169715036124902 9.09731846427341e-06 hsa-miR-197-3p PRICKLE2 -0.16253774958271 0.828233346204688 0.0177255412987654 0.969497997086328 mirMAP -0.259951469488209 8.6048620172375e-12 hsa-miR-320b PRICKLE2 -0.0203395214664157 0.930562048282019 0.0177255412987654 0.969497997086328 mirMAP -0.227440830315089 3.84313880753253e-11 hsa-miR-362-5p PRICKLE2 0.215268517371166 0.469421708227034 0.0177255412987654 0.969497997086328 mirMAP -0.277240440642943 4.36846092164439e-19 hsa-miR-500a-5p PRICKLE2 0.0097790305601746 0.958449089566593 0.0177255412987654 0.969497997086328 mirMAP -0.344234333311061 7.17467559930117e-27 hsa-miR-576-5p PRICKLE2 -0.111163544190811 0.739840245445557 0.0177255412987654 0.969497997086328 mirMAP -0.318889040233355 6.40864949657442e-19 hsa-miR-140-3p SENP2 -0.0813609197213889 0.923953795876038 -0.00108396760825791 0.998223495547818 mirMAP -0.111140304488665 5.70505657181129e-11 hsa-miR-369-3p SENP2 -0.0734607425694875 0.755351791463265 -0.00108396760825791 0.998223495547818 mirMAP -0.111437274643639 3.8132936287651e-14 hsa-miR-130a-3p BTRC -0.19782843294836 0.720491845034151 -0.113796391872094 0.818463431452382 mirMAP -0.123950670209092 1.81836770188752e-08 hsa-miR-130b-3p BTRC -0.211426879967744 0.486104856445712 -0.113796391872094 0.818463431452382 mirMAP -0.166208529900913 2.6200359050573e-14 hsa-miR-130b-5p BTRC -0.24592404944858 0.439156866715699 -0.113796391872094 0.818463431452382 mirMAP -0.0733070763756952 0.000126161987031046 hsa-miR-16-1-3p BTRC -0.172993537212073 0.391863504419512 -0.113796391872094 0.818463431452382 mirMAP -0.082740114427003 0.00141975733332752 hsa-miR-185-5p BTRC 0.0659414824247602 0.896134370932431 -0.113796391872094 0.818463431452382 mirMAP -0.27817268481314 2.83790268646345e-15 hsa-miR-186-5p BTRC -0.14779866926096 0.840248407765158 -0.113796391872094 0.818463431452382 mirMAP -0.153390623021547 3.48923481425663e-07 hsa-miR-301a-3p BTRC -0.0522829902990942 0.861546852981366 -0.113796391872094 0.818463431452382 mirMAP -0.0679813751863115 9.13685367730271e-05 hsa-miR-495-3p BTRC -0.159204559213757 0.555240058524588 -0.113796391872094 0.818463431452382 mirMAP -0.0829811628740866 5.40767217462207e-05 hsa-miR-576-5p BTRC -0.111163544190811 0.739840245445557 -0.113796391872094 0.818463431452382 mirMAP -0.106901631789694 1.17834154523049e-05 hsa-miR-590-3p BTRC -0.133358268237272 0.535686159072243 -0.113796391872094 0.818463431452382 mirMAP -0.0903308728719755 0.000117695357847757 hsa-miR-93-3p BTRC -0.211485740452515 0.540427728229387 -0.113796391872094 0.818463431452382 mirMAP -0.0695043538883102 0.00124132498272718 hsa-miR-141-5p PRKCB -0.21874832932521 0.789341690802864 -0.253273703233256 0.375512080029025 mirMAP -0.127187131565152 0.00154757873879663 hsa-miR-29b-2-5p PRKCB -0.0126563776248076 0.980563872976574 -0.253273703233256 0.375512080029025 mirMAP -0.248738713275143 5.96583916655133e-07 hsa-miR-30b-5p PRKCB -0.126278303055191 0.871574517121767 -0.253273703233256 0.375512080029025 mirMAP -0.181899501701348 0.00172429854651836 hsa-miR-30c-5p PRKCB -0.268052278300344 0.753220585849573 -0.253273703233256 0.375512080029025 mirMAP -0.266676621567604 3.26692465594906e-05 hsa-miR-30d-3p PRKCB 0.010689376681901 0.963707546423024 -0.253273703233256 0.375512080029025 mirMAP -0.176195796338334 0.00676988213351706 hsa-miR-664a-3p PRKCB 0.0260321839026805 0.956434140422838 -0.253273703233256 0.375512080029025 mirMAP -0.30918523276408 8.70938453871888e-07 hsa-let-7g-3p SMAD3 -0.39123398731129 0.399100962252738 -0.00805727245311783 0.987902560465751 mirMAP -0.0672079683938065 7.19317852072924e-05 hsa-miR-186-5p SMAD3 -0.14779866926096 0.840248407765158 -0.00805727245311783 0.987902560465751 mirMAP -0.0873125857096575 0.00250614791235026 hsa-miR-212-3p SMAD3 0.0651691163056072 0.740903353495934 -0.00805727245311783 0.987902560465751 mirMAP -0.0653395375554603 0.00366958379656575 hsa-miR-320b SMAD3 -0.0203395214664157 0.930562048282019 -0.00805727245311783 0.987902560465751 mirMAP -0.0897586559244642 4.95206636155641e-05 hsa-miR-345-5p SMAD3 -0.318796500689201 0.40673094545688 -0.00805727245311783 0.987902560465751 mirMAP -0.0609568841496714 0.000251189661803762 hsa-miR-576-5p SMAD3 -0.111163544190811 0.739840245445557 -0.00805727245311783 0.987902560465751 mirMAP -0.0823118512650115 0.000420857426041599 hsa-miR-16-2-3p AXIN2 -0.107555719075227 0.702302679752719 -0.0138759668242621 0.966117623520896 mirMAP -0.242354247916614 1.68855735572963e-12 hsa-miR-148a-5p CXXC4 -0.200917166615887 0.667057353234933 -0.189634120723988 0.402205830601326 mirMAP -0.113422138971705 0.0441472444914234 hsa-miR-186-5p CXXC4 -0.14779866926096 0.840248407765158 -0.189634120723988 0.402205830601326 mirMAP -0.185188272588669 0.00861357423571367 hsa-miR-21-5p CXXC4 0.0148493782366828 0.992419670576308 -0.189634120723988 0.402205830601326 mirMAP -0.257452952558405 3.19200115682289e-05 hsa-miR-590-3p CXXC4 -0.133358268237272 0.535686159072243 -0.189634120723988 0.402205830601326 mirMAP -0.22340700282172 4.26165162563516e-05 hsa-miR-590-5p CXXC4 -0.131787544750195 0.684613701486826 -0.189634120723988 0.402205830601326 mirMAP -0.220064131956899 2.44213519940944e-05 hsa-miR-195-5p VANGL1 -0.00971531160236339 0.98418421453416 -0.0952455706302153 0.850760454545912 mirMAP -0.234198291882211 1.61785278026182e-23 hsa-miR-218-5p VANGL1 -0.0827242549860268 0.862446853499361 -0.0952455706302153 0.850760454545912 mirMAP -0.227997550601069 9.78752605670574e-18 hsa-miR-26a-5p VANGL1 -0.0558466394626773 0.953979749143751 -0.0952455706302153 0.850760454545912 mirMAP -0.376690599739968 1.73365456652659e-24 hsa-miR-320a VANGL1 0.0425274543382255 0.958191670788918 -0.0952455706302153 0.850760454545912 mirMAP -0.136314967525611 1.82491693402936e-05 hsa-miR-382-5p VANGL1 -0.228375626004774 0.56391690806798 -0.0952455706302153 0.850760454545912 mirMAP -0.0691584537218872 0.0024455798995836 hsa-miR-452-5p VANGL1 -0.0590392811106577 0.906930362717493 -0.0952455706302153 0.850760454545912 mirMAP -0.0682184139257755 2.89813686261973e-07 hsa-miR-485-3p VANGL1 -0.200882988600113 0.355387948738328 -0.0952455706302153 0.850760454545912 mirMAP -0.112215433433973 2.23086646351406e-07 hsa-miR-664a-3p VANGL1 0.0260321839026805 0.956434140422838 -0.0952455706302153 0.850760454545912 mirMAP -0.0637486039728286 0.0240501354246525 hsa-miR-130a-3p VANGL1 -0.19782843294836 0.720491845034151 -0.0952455706302153 0.850760454545912 mirMAP -0.13320016720032 5.81451951775816e-10 hsa-miR-214-3p VANGL1 -0.110449829460212 0.670567263185672 -0.0952455706302153 0.850760454545912 mirMAP -0.137565470387465 8.31314037723104e-12 hsa-let-7a-3p FZD4 -0.130729276906521 0.779692030572974 0.0304707076358319 0.955399406040093 mirMAP -0.407977804308959 4.19813220404563e-15 hsa-let-7f-1-3p FZD4 -0.222769653030984 0.176243975299018 0.0304707076358319 0.955399406040093 mirMAP -0.196958732723448 1.81775392431145e-06 hsa-miR-130b-3p FZD4 -0.211426879967744 0.486104856445712 0.0304707076358319 0.955399406040093 mirMAP -0.413297584170443 1.17616241857261e-31 hsa-miR-132-3p FZD4 0.0245028522614428 0.964849701708711 0.0304707076358319 0.955399406040093 mirMAP -0.131849182622165 0.0215519807956623 hsa-miR-200b-3p FZD4 -0.109983892590611 0.891357972128093 0.0304707076358319 0.955399406040093 mirMAP -0.443472478111004 1.62241648876776e-56 hsa-miR-200c-3p FZD4 -0.0449560636499466 0.969433069399071 0.0304707076358319 0.955399406040093 mirMAP -0.5394698778619 2.40222703670541e-71 hsa-miR-212-3p FZD4 0.0651691163056072 0.740903353495934 0.0304707076358319 0.955399406040093 mirMAP -0.106820495464605 0.0061660372674424 hsa-miR-21-5p FZD4 0.0148493782366828 0.992419670576308 0.0304707076358319 0.955399406040093 mirMAP -0.617423104849022 4.14640575991911e-50 hsa-miR-25-3p FZD4 0.0550592306329012 0.962829613775088 0.0304707076358319 0.955399406040093 mirMAP -0.311311688515217 6.52111955612921e-07 hsa-miR-301a-3p FZD4 -0.0522829902990942 0.861546852981366 0.0304707076358319 0.955399406040093 mirMAP -0.296293129313005 3.03122689456589e-26 hsa-miR-3065-3p FZD4 0.22426467087409 0.627407590125411 0.0304707076358319 0.955399406040093 mirMAP -0.21363490263864 4.05907439854592e-17 hsa-miR-32-5p FZD4 -0.218686304292785 0.59094441655546 0.0304707076358319 0.955399406040093 mirMAP -0.393954741435993 7.79828021744844e-23 hsa-miR-429 FZD4 -0.142589289838583 0.802317907773415 0.0304707076358319 0.955399406040093 mirMAP -0.419642690763874 1.62254290929758e-64 hsa-miR-454-3p FZD4 -0.0807547300787816 0.779337172929459 0.0304707076358319 0.955399406040093 mirMAP -0.33333483404347 1.07749136844395e-22 hsa-miR-455-3p FZD4 -0.332546859679539 0.617979023781481 0.0304707076358319 0.955399406040093 mirMAP -0.187203964079631 1.23489599175754e-13 hsa-miR-576-5p FZD4 -0.111163544190811 0.739840245445557 0.0304707076358319 0.955399406040093 mirMAP -0.1856965803836 4.20641790446917e-06 hsa-miR-590-5p FZD4 -0.131787544750195 0.684613701486826 0.0304707076358319 0.955399406040093 mirMAP -0.331595766851545 7.67537979959466e-20 hsa-miR-7-1-3p FZD4 -0.0332815306858167 0.935725386085843 0.0304707076358319 0.955399406040093 mirMAP -0.224934472313498 1.05455748906568e-09 hsa-miR-92a-3p FZD4 -0.0230307937945682 0.984317735692711 0.0304707076358319 0.955399406040093 mirMAP -0.301979533216699 2.02325930056432e-10 hsa-miR-92b-3p FZD4 -0.0975289498867111 0.871999313512183 0.0304707076358319 0.955399406040093 mirMAP -0.348983639703719 6.88519966120482e-22 hsa-miR-146b-5p SMAD2 0.00834882458611474 0.991577009242932 -0.0519399062136339 0.930776806456225 mirMAP -0.0784755866153152 1.40945643948323e-07 hsa-miR-181a-5p SMAD2 0.0637093750406734 0.945876131429707 -0.0519399062136339 0.930776806456225 mirMAP -0.115122429788219 8.47012412856965e-11 hsa-miR-181b-5p SMAD2 0.0375130667115933 0.959555096276237 -0.0519399062136339 0.930776806456225 mirMAP -0.112879931507918 3.62142519922135e-14 hsa-miR-26a-5p SMAD2 -0.0558466394626773 0.953979749143751 -0.0519399062136339 0.930776806456225 mirMAP -0.076216354764885 0.00103388430020276 hsa-miR-374a-3p SMAD2 -0.0781632437076389 0.926379383884834 -0.0519399062136339 0.930776806456225 mirMAP -0.0726506566736111 0.000894468846573258 hsa-miR-125b-2-3p TBL1XR1 -0.19521949049782 0.618072714328679 -0.115313887374555 0.864767739366221 mirMAP -0.0911932546849338 1.40219628923977e-09 hsa-miR-181a-5p TBL1XR1 0.0637093750406734 0.945876131429707 -0.115313887374555 0.864767739366221 mirMAP -0.0846812957345653 0.000435850729153325 hsa-miR-195-3p TBL1XR1 -0.0314657373015459 0.893921960533907 -0.115313887374555 0.864767739366221 mirMAP -0.0951504949122388 1.67230564431063e-06 hsa-miR-376c-3p TBL1XR1 -0.207862770329174 0.336782853961576 -0.115313887374555 0.864767739366221 mirMAP -0.060570926182865 0.000136799173593176 hsa-miR-125a-5p CTNNBIP1 0.00741438556537055 0.993308396064258 -0.0617522470279912 0.902562563271752 mirMAP -0.106861426150118 3.21438994353657e-05 hsa-miR-16-2-3p PLCB1 -0.107555719075227 0.702302679752719 0.16954029991043 0.64744751250053 mirMAP -0.181891575863844 0.000186734623561594 hsa-miR-340-5p PLCB1 0.0820090452273905 0.816484190854532 0.16954029991043 0.64744751250053 mirMAP -0.145430096241242 0.00999016493511445 hsa-miR-182-5p PRKX -0.101509746042318 0.939206381321837 -0.16691261365817 0.713645814762555 mirMAP -0.175194994974604 2.67502751484288e-08 hsa-miR-29b-3p PRKX -0.147629200668355 0.855068431567557 -0.16691261365817 0.713645814762555 mirMAP -0.120330213613139 0.0037387071410825 hsa-miR-29c-3p PRKX -0.0526710652467877 0.956320854458284 -0.16691261365817 0.713645814762555 mirMAP -0.38827959473025 7.47361121556913e-23 hsa-miR-625-3p PRKX -0.00228224713043801 0.997356315686925 -0.16691261365817 0.713645814762555 mirMAP -0.146145038207053 0.00114969241015916 hsa-miR-96-5p PRKX -0.153312892459014 0.726115467443483 -0.16691261365817 0.713645814762555 mirMAP -0.0881547950946653 0.00079894964726611 hsa-miR-10b-5p WNT7B 0.0860066308485106 0.952735981646638 0.203059513313665 0.583576542147028 mirMAP -0.19739104901179 0.00088619253374349 hsa-miR-491-5p WNT7B -0.423577120749209 0.0220584227099558 0.203059513313665 0.583576542147028 mirMAP -0.270664526249752 2.96434624276917e-06 hsa-miR-340-5p PPP3R1 0.0820090452273905 0.816484190854532 -0.0271826487262787 0.962679518571233 mirMAP -0.0619721457875075 0.00037248177045784 hsa-let-7a-3p WNT5A -0.130729276906521 0.779692030572974 -0.37564066226164 0.355542462686927 miRNATAP -0.22117753231769 0.000441970481202632 hsa-let-7a-3p SFRP2 -0.130729276906521 0.779692030572974 -0.000608038423459689 0.999366127714656 miRNATAP -0.332636167789599 4.93713573566124e-06 hsa-let-7a-3p AXIN2 -0.130729276906521 0.779692030572974 -0.0138759668242621 0.966117623520896 miRNATAP -0.155309998742421 0.00126021107839157 hsa-miR-32-5p NFAT5 -0.218686304292785 0.59094441655546 -0.140634566870934 0.80102714017311 miRNATAP -0.186203151817271 3.61328449313256e-14 hsa-miR-32-5p FZD10 -0.218686304292785 0.59094441655546 -0.157448402775842 0.382566977418384 miRNATAP -0.123938793775156 0.0156379360391019 hsa-miR-32-5p DAAM1 -0.218686304292785 0.59094441655546 -0.0539991515887506 0.906596879539895 miRNATAP -0.184869801891824 6.4290036355108e-08 hsa-miR-32-5p JUN -0.218686304292785 0.59094441655546 -0.108657195258627 0.877583083771737 miRNATAP -0.263951179853313 2.73587232573327e-13 hsa-miR-30a-5p PLCB4 -0.315304933842571 0.81611555406281 0.0386799314732373 0.922546084561183 miRNATAP -0.0890610879244375 0.0375221599810825 hsa-miR-30a-5p PRICKLE1 -0.315304933842571 0.81611555406281 -0.101221821514089 0.815959595958142 miRNATAP -0.136509847501526 7.9340765409784e-07 hsa-miR-30a-5p PPP2R1B -0.315304933842571 0.81611555406281 -0.00522798350256881 0.991408260059311 miRNATAP -0.0629574134561096 0.00225790081481894 hsa-miR-30a-5p WNT7B -0.315304933842571 0.81611555406281 0.203059513313665 0.583576542147028 miRNATAP -0.244710473588963 1.09537488646518e-06 hsa-miR-96-5p PRKACB -0.153312892459014 0.726115467443483 -0.0742837105484302 0.886731753016865 miRNATAP -0.0911062171827352 0.00250648512206787 hsa-miR-20b-5p CCND2 -0.275771697228234 0.506979861341138 -0.168931301767903 0.722558871099741 miRNATAP -0.104708964184932 6.77204420924901e-08 hsa-miR-20b-5p PPP3CA -0.275771697228234 0.506979861341138 -0.078895894384611 0.886413963353503 miRNATAP -0.0563413508601391 0.000470296550304845 hsa-miR-106b-5p PLCB1 -0.0853499657102335 0.901700669947609 0.16954029991043 0.64744751250053 miRNATAP -0.353580999854292 7.45108046911457e-10 hsa-miR-106b-5p FZD4 -0.0853499657102335 0.901700669947609 0.0304707076358319 0.955399406040093 miRNATAP -0.578879980215605 3.05048677233544e-41 hsa-miR-106b-5p PPP3CA -0.0853499657102335 0.901700669947609 -0.078895894384611 0.886413963353503 miRNATAP -0.163746270795427 4.48730421523751e-08 hsa-miR-106b-5p FBXW11 -0.0853499657102335 0.901700669947609 0.00937498411107818 0.985997496641178 miRNATAP -0.176360910717368 7.82361659308432e-22 hsa-miR-106b-5p FZD7 -0.0853499657102335 0.901700669947609 -0.175347860746907 0.737019399304957 miRNATAP -0.0854775322671486 0.041684325488087 hsa-miR-106b-5p EP300 -0.0853499657102335 0.901700669947609 -0.0381739592699031 0.951249053975231 miRNATAP -0.191649543350323 2.95239597393248e-13 hsa-let-7g-5p CCND1 -0.168556367162896 0.835060549207039 0.0138594286077627 0.985644356886489 miRNATAP -0.162141133652712 0.0318118533604679 hsa-miR-106a-5p CCND2 -0.142040012764908 0.692192967482747 -0.168931301767903 0.722558871099741 miRNATAP -0.117204496646304 5.04333413242193e-06 hsa-miR-23b-3p CCND1 -0.158093770583088 0.851138252196472 0.0138594286077627 0.985644356886489 miRNATAP -0.2085521275068 0.000237936656088415 hsa-miR-23b-3p FRAT2 -0.158093770583088 0.851138252196472 -0.0156891928833645 0.96774417787488 miRNATAP -0.0655982601931967 0.0181033146285602 hsa-miR-23b-3p FRAT1 -0.158093770583088 0.851138252196472 0.0717364474803182 0.782088380245773 miRNATAP -0.272278749887034 6.57021937322535e-18 hsa-miR-3613-5p NFAT5 -0.255417595166074 0.404939118148321 -0.140634566870934 0.80102714017311 miRNATAP -0.103018827085653 2.39140009917872e-05 hsa-miR-126-5p AXIN1 -0.0509133532389665 0.941546676673956 -0.0653528137130222 0.894667807615627 miRNATAP -0.232873177453548 6.89302611938727e-24 hsa-miR-374a-3p CREBBP -0.0781632437076389 0.926379383884834 -0.121528460671809 0.849036225288355 miRNATAP -0.118175129899399 3.92114134022804e-06 hsa-miR-141-3p JUN -0.179420502124191 0.83354105481228 -0.108657195258627 0.877583083771737 miRNATAP -0.26513026030347 4.33514873445987e-29 hsa-miR-218-5p PPP2R5D -0.0827242549860268 0.862446853499361 0.0854554677410553 0.877127199238575 miRNATAP -0.0933622383557136 4.07886414816651e-08 hsa-miR-93-5p FBXW11 0.0554251653547535 0.959380932710413 0.00937498411107818 0.985997496641178 miRNATAP -0.149796521194947 1.90586895576967e-16 hsa-miR-93-5p PLCB1 0.0554251653547535 0.959380932710413 0.16954029991043 0.64744751250053 miRNATAP -0.375873317446529 2.70002798262841e-11 hsa-miR-93-5p CCND2 0.0554251653547535 0.959380932710413 -0.168931301767903 0.722558871099741 miRNATAP -0.400435186075896 5.37578279205249e-31 22180714 The miRNA microarray results were further validated with quantitative RT-PCR miR-93 was downregulated and its predicted mRNA targets included BAMBI CCND2 CDKN1A HDAC8 KIF23 MAP3K9 MAP3K11 MYCN PPARD TLE4 and ZDHHC1 colorectal cancer hsa-miR-93-5p PPP3CA 0.0554251653547535 0.959380932710413 -0.078895894384611 0.886413963353503 miRNATAP -0.162948227314112 3.15959129159339e-08 hsa-miR-200a-3p PPP3R1 -0.192839143060886 0.77994979695622 -0.0271826487262787 0.962679518571233 miRNATAP -0.0631015819573042 2.5955329177943e-09 hsa-miR-200a-3p JUN -0.192839143060886 0.77994979695622 -0.108657195258627 0.877583083771737 miRNATAP -0.179081800592841 4.16743748553287e-14 hsa-miR-155-5p CHD8 -0.167418736137707 0.822294484498835 -0.0178510158573202 0.976383552659853 miRNATAP -0.0606721930934058 1.55950788957256e-06 hsa-miR-365a-3p NKD1 0.0307303320006067 0.959616484776468 -0.180903345728981 0.226242418703525 miRNATAP -0.0914851843885741 0.033248573496006 hsa-miR-502-3p CSNK1A1 -0.112324660408878 0.668115269202166 -0.0165042555609478 0.982452723332151 miRNATAP -0.176013262432281 1.80237661044146e-22 hsa-miR-589-5p CTNNB1 -0.0214815940746442 0.967157138449855 -0.0805864772545046 0.91992258189981 miRNATAP -0.163417588837067 5.37234569206233e-10 hsa-miR-589-5p SMAD4 -0.0214815940746442 0.967157138449855 -0.0337260829637342 0.952673159973339 miRNATAP -0.184456440754787 1.53364140974385e-13 hsa-miR-18a-5p PRKACB -0.060215066151506 0.836155187457355 -0.0742837105484302 0.886731753016865 miRNATAP -0.109828861303179 0.000270889162356874 hsa-miR-10a-5p CTNNBIP1 0.255396588065263 0.844875410767462 -0.0617522470279912 0.902562563271752 miRNATAP -0.0741046317187381 1.51001364187345e-05 hsa-miR-3607-3p NFATC4 -0.410705558355355 0.442005238257379 0.118767632463774 0.80554796605913 miRNATAP -0.103148919948283 1.40847070939603e-05 hsa-miR-101-3p GSK3B -0.140525462772132 0.906382304639665 -0.0660851428212252 0.908304623747486 miRNATAP -0.1804025732635 1.07790099640944e-12 hsa-miR-101-3p PPP3R1 -0.140525462772132 0.906382304639665 -0.0271826487262787 0.962679518571233 miRNATAP -0.187171459954337 1.17776284425277e-17 hsa-miR-24-3p MAPK9 -0.156339520113363 0.865374272536865 -0.00950322920821378 0.985902275586564 miRNATAP -0.089711175549304 9.40591598696063e-05 hsa-miR-24-3p NLK -0.156339520113363 0.865374272536865 -0.0075726819422437 0.986090753913933 miRNATAP -0.110962647460226 4.40407432880344e-05 hsa-miR-3065-3p PPP3CA 0.22426467087409 0.627407590125411 -0.078895894384611 0.886413963353503 miRNATAP -0.0743114376451225 1.50224279542979e-05 hsa-miR-3065-3p LRP6 0.22426467087409 0.627407590125411 -0.261612069159627 0.621254118198097 miRNATAP -0.0515320607235006 0.0033408990941163 hsa-miR-15b-3p TCF7L2 -0.126451993800397 0.773147230209712 -0.151922190442888 0.739870566881007 miRNATAP -0.105562680055541 3.49079711601082e-05 hsa-miR-409-5p CTBP1 -0.337047308676109 0.319120566059885 -0.00426146109334713 0.994460970584857 miRNATAP -0.0587457554026441 4.92014294322226e-06 hsa-miR-29b-3p LRP6 -0.147629200668355 0.855068431567557 -0.261612069159627 0.621254118198097 miRNATAP -0.092639695426931 0.00198525387360265 hsa-miR-29b-3p NFATC4 -0.147629200668355 0.855068431567557 0.118767632463774 0.80554796605913 miRNATAP -0.122774285938033 0.00449585095871782 hsa-miR-29b-3p MAPK10 -0.147629200668355 0.855068431567557 -0.469554749724375 0.0904444026222832 miRNATAP -0.214951327451731 0.00114851870928561 hsa-miR-324-3p FZD4 -0.0533960575545418 0.892365633037602 0.0304707076358319 0.955399406040093 miRNATAP -0.308721358633824 3.19173797166468e-13 hsa-miR-484 PRICKLE2 -0.167034215156431 0.771225151614856 0.0177255412987654 0.969497997086328 miRNATAP -0.21226644714009 8.08847112830986e-08 hsa-miR-222-3p AXIN2 -0.0901542670760289 0.851836230793884 -0.0138759668242621 0.966117623520896 miRNATAP -0.187336402293767 2.41688030584989e-08 hsa-miR-221-3p AXIN2 -0.0578227721969284 0.924067621219326 -0.0138759668242621 0.966117623520896 miRNATAP -0.187234880985831 2.24061800824779e-07 hsa-miR-212-3p NLK 0.0651691163056072 0.740903353495934 -0.0075726819422437 0.986090753913933 miRNATAP -0.0808058358945876 0.000120599050777903 hsa-miR-452-5p CXXC4 -0.0590392811106577 0.906930362717493 -0.189634120723988 0.402205830601326 miRNATAP -0.234320108333777 8.18417899337699e-14 hsa-miR-361-3p SMAD2 -0.0127254134873924 0.984476698818773 -0.0519399062136339 0.930776806456225 miRNATAP -0.128521633108847 3.38235989722682e-08 hsa-miR-628-5p CAMK2B -0.425043070183919 0.319271894365573 0.141283778852512 0.60471522191955 miRNATAP -0.162840590843991 0.000430398534263797 hsa-miR-628-5p PLCB2 -0.425043070183919 0.319271894365573 0.046924896357516 0.890573590890969 miRNATAP -0.0892433090628924 3.83115554899696e-06 hsa-miR-34a-5p SMAD4 -0.00150684423480296 0.998107346259152 -0.0337260829637342 0.952673159973339 miRNATAP -0.0970813582287062 0.000114939393150447 hsa-miR-34a-5p PLCB1 -0.00150684423480296 0.998107346259152 0.16954029991043 0.64744751250053 miRNATAP -0.159895868887965 0.0280175727961689 hsa-miR-26a-5p NLK -0.0558466394626773 0.953979749143751 -0.0075726819422437 0.986090753913933 miRNATAP -0.184587948058077 8.44159773363628e-08 hsa-miR-26a-5p FRAT2 -0.0558466394626773 0.953979749143751 -0.0156891928833645 0.96774417787488 miRNATAP -0.149885015101282 3.81360261100518e-05 hsa-miR-26a-5p CAMK2A -0.0558466394626773 0.953979749143751 -0.202058295390148 0.395922649310232 miRNATAP -0.226702776972991 0.00412036831502982 hsa-let-7a-5p PLCB4 -0.0656092877172174 0.961124733677684 0.0386799314732373 0.922546084561183 miRNATAP -0.164772567366254 0.048408998790875 hsa-miR-629-3p FZD4 -0.203962319893151 0.416043359122368 0.0304707076358319 0.955399406040093 miRNATAP -0.23213209252431 2.89292527551865e-15 hsa-miR-409-3p CTBP1 -0.189095517827509 0.636954104687463 -0.00426146109334713 0.994460970584857 miRNATAP -0.123267122301907 3.51783238534121e-13 hsa-miR-409-3p NLK -0.189095517827509 0.636954104687463 -0.0075726819422437 0.986090753913933 miRNATAP -0.0669857866797472 0.00255957829107503 hsa-miR-183-5p LRP6 -0.0285894962233133 0.980944848059819 -0.261612069159627 0.621254118198097 miRNATAP -0.108472989759681 7.08115025900927e-08 hsa-miR-183-5p PRKCA -0.0285894962233133 0.980944848059819 -0.227245147154052 0.467261641689546 miRNATAP -0.382401275003301 4.39521361355191e-39 hsa-miR-183-5p PLCB4 -0.0285894962233133 0.980944848059819 0.0386799314732373 0.922546084561183 miRNATAP -0.0889593194834198 0.025711954226381 hsa-miR-183-5p CCND2 -0.0285894962233133 0.980944848059819 -0.168931301767903 0.722558871099741 miRNATAP -0.301857921065621 1.16754966176673e-39 hsa-miR-214-3p GSK3B -0.110449829460212 0.670567263185672 -0.0660851428212252 0.908304623747486 miRNATAP -0.0861528554138963 3.20947339490034e-08 hsa-miR-21-5p PPP3CA 0.0148493782366828 0.992419670576308 -0.078895894384611 0.886413963353503 miRNATAP -0.171857455775929 3.70280677648987e-09 hsa-miR-30d-5p CAMK2D 0.00512174341017158 0.996390931509314 -0.130338203405614 0.785364834465144 miRNATAP -0.0917104798857512 0.0398248839394852 hsa-miR-30d-5p PPP2R1B 0.00512174341017158 0.996390931509314 -0.00522798350256881 0.991408260059311 miRNATAP -0.0739131720495206 0.0432717400554516 hsa-miR-30d-5p PRICKLE1 0.00512174341017158 0.996390931509314 -0.101221821514089 0.815959595958142 miRNATAP -0.25925039080586 1.16398766251352e-07 hsa-miR-92b-3p FZD10 -0.0975289498867111 0.871999313512183 -0.157448402775842 0.382566977418384 miRNATAP -0.138813280698489 0.00275447570293217 hsa-miR-92b-3p NFAT5 -0.0975289498867111 0.871999313512183 -0.140634566870934 0.80102714017311 miRNATAP -0.163288708475086 2.29328643304621e-13 hsa-miR-92b-3p JUN -0.0975289498867111 0.871999313512183 -0.108657195258627 0.877583083771737 miRNATAP -0.135248670230231 4.27496884553493e-05 hsa-miR-92b-3p CTNNBIP1 -0.0975289498867111 0.871999313512183 -0.0617522470279912 0.902562563271752 miRNATAP -0.0631120307242892 0.000953676887547371 hsa-miR-146b-3p GSK3B -0.1135898237745 0.845150013332062 -0.0660851428212252 0.908304623747486 miRNATAP -0.0696074372323128 0.000364530062856794 hsa-miR-769-5p SMAD3 -0.10362464632991 0.793365222563107 -0.00805727245311783 0.987902560465751 miRNATAP -0.121091427985316 6.14487597806327e-05 hsa-miR-19a-3p PLCB1 -0.00951638786771092 0.980991306004163 0.16954029991043 0.64744751250053 miRNATAP -0.133824099939887 0.00125180775640206 hsa-miR-19a-3p DAAM1 -0.00951638786771092 0.980991306004163 -0.0539991515887506 0.906596879539895 miRNATAP -0.190478397802553 1.17645107395773e-12 hsa-miR-19a-3p MAPK10 -0.00951638786771092 0.980991306004163 -0.469554749724375 0.0904444026222832 miRNATAP -0.222702615462015 4.17842244233184e-06 hsa-miR-19b-3p CCND1 -0.0314903804749491 0.95913844863355 0.0138594286077627 0.985644356886489 miRNATAP -0.249444343540709 5.93160032007176e-08 hsa-miR-19b-3p DAAM1 -0.0314903804749491 0.95913844863355 -0.0539991515887506 0.906596879539895 miRNATAP -0.169719982996084 2.92738495486855e-07 hsa-miR-19b-3p MAPK10 -0.0314903804749491 0.95913844863355 -0.469554749724375 0.0904444026222832 miRNATAP -0.182028621380633 0.00223666160802019 hsa-miR-582-5p AXIN2 -0.25536438153407 0.299823930850699 -0.0138759668242621 0.966117623520896 miRNATAP -0.23410335462888 1.51202842984391e-13 hsa-miR-582-5p SFRP2 -0.25536438153407 0.299823930850699 -0.000608038423459689 0.999366127714656 miRNATAP -0.11158761801029 0.0221651196488598 hsa-miR-582-5p NLK -0.25536438153407 0.299823930850699 -0.0075726819422437 0.986090753913933 miRNATAP -0.0703776196601652 0.000208840583163923 hsa-miR-200c-3p PRKCA -0.0449560636499466 0.969433069399071 -0.227245147154052 0.467261641689546 miRNATAP -0.384868851727468 4.79014422420278e-32 23497265 The integrated analysis of miRNA and mRNA expression identified 35 known and novel target genes of miR-200c miR-205 and mir-375 including CFL2 LAMC1 TIMP2 ZEB1 CDH11 PRKCA PTPRJ PTPRM LDHB and SEC23A breast cancer hsa-miR-26b-5p FRAT2 -0.165683456923659 0.842739329770527 -0.0156891928833645 0.96774417787488 miRNATAP -0.063047884587289 0.0287826807598239 hsa-miR-26b-5p CAMK2A -0.165683456923659 0.842739329770527 -0.202058295390148 0.395922649310232 miRNATAP -0.201669642863581 0.00121808822640433 hsa-miR-20a-5p VANGL1 0.0648697217907399 0.924634007033878 -0.0952455706302153 0.850760454545912 miRNATAP -0.0857464974206918 8.37257357301245e-05 hsa-miR-20a-5p PLCB1 0.0648697217907399 0.924634007033878 0.16954029991043 0.64744751250053 miRNATAP -0.199775783667376 2.30541192654188e-05 hsa-miR-20a-5p PPP3CA 0.0648697217907399 0.924634007033878 -0.078895894384611 0.886413963353503 miRNATAP -0.110326267376209 6.81988772591416e-06 hsa-miR-20a-5p FZD4 0.0648697217907399 0.924634007033878 0.0304707076358319 0.955399406040093 miRNATAP -0.349126822049724 3.50595644995987e-22 hsa-miR-20a-5p FBXW11 0.0648697217907399 0.924634007033878 0.00937498411107818 0.985997496641178 miRNATAP -0.144291334426437 6.70457379214045e-22 hsa-miR-20a-5p EP300 0.0648697217907399 0.924634007033878 -0.0381739592699031 0.951249053975231 miRNATAP -0.151748232339608 1.59846335234487e-12 hsa-miR-148b-3p NFAT5 -0.121415535518017 0.85232232285121 -0.140634566870934 0.80102714017311 miRNATAP -0.132221606001518 1.3758614517174e-05 hsa-miR-301a-3p PLCB1 -0.0522829902990942 0.861546852981366 0.16954029991043 0.64744751250053 miRNATAP -0.142645627899033 0.000107371010712177 hsa-miR-301a-3p MAPK10 -0.0522829902990942 0.861546852981366 -0.469554749724375 0.0904444026222832 miRNATAP -0.20354840914367 2.22032173676851e-06 hsa-miR-301a-3p CXXC4 -0.0522829902990942 0.861546852981366 -0.189634120723988 0.402205830601326 miRNATAP -0.0916917973450284 0.023845054933955 hsa-let-7i-5p CCND1 -0.0150044050672964 0.984758993703736 0.0138594286077627 0.985644356886489 miRNATAP -0.759700962013673 2.31065071397228e-16 hsa-let-7i-5p NLK -0.0150044050672964 0.984758993703736 -0.0075726819422437 0.986090753913933 miRNATAP -0.413862391863088 2.49706725878225e-22 hsa-let-7i-5p MAPK9 -0.0150044050672964 0.984758993703736 -0.00950322920821378 0.985902275586564 miRNATAP -0.306833929478603 2.50065627421339e-17 hsa-miR-429 PLCB1 -0.142589289838583 0.802317907773415 0.16954029991043 0.64744751250053 miRNATAP -0.224224441826941 4.11678198698433e-11 hsa-miR-429 NFATC3 -0.142589289838583 0.802317907773415 -0.00280369997980578 0.995287940001814 miRNATAP -0.0774131781570528 1.39609237234483e-10 hsa-miR-429 NFAT5 -0.142589289838583 0.802317907773415 -0.140634566870934 0.80102714017311 miRNATAP -0.139784505249335 1.85265208110627e-18 hsa-miR-429 MAPK10 -0.142589289838583 0.802317907773415 -0.469554749724375 0.0904444026222832 miRNATAP -0.366481358214565 1.02092652001284e-20 hsa-miR-429 DAAM1 -0.142589289838583 0.802317907773415 -0.0539991515887506 0.906596879539895 miRNATAP -0.0989968840952209 9.62745684692713e-06 hsa-miR-429 PRICKLE2 -0.142589289838583 0.802317907773415 0.0177255412987654 0.969497997086328 miRNATAP -0.259740006651794 1.66095895526273e-28 hsa-miR-429 WNT2B -0.142589289838583 0.802317907773415 -0.120458000644347 0.404153656056463 miRNATAP -0.137551404474967 5.5132158702989e-08 hsa-miR-429 SFRP1 -0.142589289838583 0.802317907773415 -0.472006437969406 0.460625213922239 miRNATAP -0.482539995817486 1.02848505471575e-13 hsa-miR-429 TCF7L2 -0.142589289838583 0.802317907773415 -0.151922190442888 0.739870566881007 miRNATAP -0.171121027184894 1.09303298527548e-16 hsa-miR-429 WNT11 -0.142589289838583 0.802317907773415 0.0262086605426326 0.924129346660332 miRNATAP -0.283953214425953 3.59806376562941e-10 hsa-miR-429 DAAM2 -0.142589289838583 0.802317907773415 -0.0621191173439439 0.879009045386603 miRNATAP -0.337876466411536 9.09263363484589e-41 hsa-miR-429 LRP6 -0.142589289838583 0.802317907773415 -0.261612069159627 0.621254118198097 miRNATAP -0.0726553446325162 6.31650476300818e-05 hsa-miR-429 SMAD3 -0.142589289838583 0.802317907773415 -0.00805727245311783 0.987902560465751 miRNATAP -0.102063359852527 2.55000912428033e-11 hsa-miR-429 CCND2 -0.142589289838583 0.802317907773415 -0.168931301767903 0.722558871099741 miRNATAP -0.232180070081619 1.04111918722712e-28 hsa-miR-508-3p FZD4 -0.000309617571689902 0.999135648467985 0.0304707076358319 0.955399406040093 miRNATAP -0.0936057765098908 0.00013600218893617 hsa-miR-10b-5p CTNNBIP1 0.0860066308485106 0.952735981646638 -0.0617522470279912 0.902562563271752 miRNATAP -0.0656794071997898 0.000695819611886468 hsa-miR-331-5p CCND2 -0.143249163277681 0.38317955643253 -0.168931301767903 0.722558871099741 miRNATAP -0.224823939820064 1.69348201302645e-09 hsa-miR-146b-5p VANGL1 0.00834882458611474 0.991577009242932 -0.0952455706302153 0.850760454545912 miRNATAP -0.0739761783479692 0.00249360697508712 hsa-miR-15b-5p CCND2 0.0382341477298391 0.953925647243518 -0.168931301767903 0.722558871099741 miRNATAP -0.200863767053961 1.18885859507843e-09 hsa-miR-15b-5p FZD10 0.0382341477298391 0.953925647243518 -0.157448402775842 0.382566977418384 miRNATAP -0.294791552759113 8.30312298544766e-09 hsa-miR-29c-3p LRP6 -0.0526710652467877 0.956320854458284 -0.261612069159627 0.621254118198097 miRNATAP -0.208977926908057 4.45236680313107e-13 hsa-miR-29c-3p PPARD -0.0526710652467877 0.956320854458284 0.111680073842304 0.824545992844611 miRNATAP -0.128141556480419 7.98900291845159e-11 hsa-miR-29c-3p FRAT2 -0.0526710652467877 0.956320854458284 -0.0156891928833645 0.96774417787488 miRNATAP -0.0584489410629572 0.0170420573539978 hsa-miR-29c-3p GSK3B -0.0526710652467877 0.956320854458284 -0.0660851428212252 0.908304623747486 miRNATAP -0.148921210430456 1.24088422020447e-14 hsa-let-7f-5p NLK -0.052676842774197 0.963441505261455 -0.0075726819422437 0.986090753913933 miRNATAP -0.0629131599618577 0.0170756812828465 hsa-let-7f-5p MAPK9 -0.052676842774197 0.963441505261455 -0.00950322920821378 0.985902275586564 miRNATAP -0.0616632320493837 0.00565738700295018 hsa-let-7f-5p PPP3CA -0.052676842774197 0.963441505261455 -0.078895894384611 0.886413963353503 miRNATAP -0.102194254433793 0.00165189815382032 hsa-miR-340-5p WNT5A 0.0820090452273905 0.816484190854532 -0.37564066226164 0.355542462686927 miRNATAP -0.151352324882194 0.00401003633166406 hsa-miR-340-5p NFATC2 0.0820090452273905 0.816484190854532 -0.38368313501719 0.1310673127204 miRNATAP -0.377355443179726 1.70562760392822e-08 hsa-miR-25-3p NFAT5 0.0550592306329012 0.962829613775088 -0.140634566870934 0.80102714017311 miRNATAP -0.077552472797379 0.0423646333648339 hsa-miR-25-3p FZD10 0.0550592306329012 0.962829613775088 -0.157448402775842 0.382566977418384 miRNATAP -0.348866342513126 7.96845323691697e-06 hsa-miR-455-3p CSNK1A1 -0.332546859679539 0.617979023781481 -0.0165042555609478 0.982452723332151 miRNATAP -0.0608474812685666 2.08964434117700e-09 hsa-miR-455-3p JUN -0.332546859679539 0.617979023781481 -0.108657195258627 0.877583083771737 miRNATAP -0.147720631567845 5.98195601818343e-11 hsa-miR-181c-5p CAMK2G -0.18121298802215 0.718350072627076 0.119349300317351 0.7992742190937 miRNATAP -0.0589638848769578 0.000382339689970459 hsa-miR-338-3p CAMK2A -0.00932885158849928 0.989745642009026 -0.202058295390148 0.395922649310232 miRNATAP -0.209986268079133 4.80281615465648e-07 hsa-miR-132-3p NLK 0.0245028522614428 0.964849701708711 -0.0075726819422437 0.986090753913933 miRNATAP -0.147434106687348 1.72134800695252e-06 hsa-miR-130a-3p CXXC4 -0.19782843294836 0.720491845034151 -0.189634120723988 0.402205830601326 miRNATAP -0.241623697494787 2.61410952091639e-06 hsa-miR-27a-3p NLK -0.0713791016390708 0.936296470694396 -0.0075726819422437 0.986090753913933 miRNATAP -0.108956811004123 0.000196776667929282 hsa-miR-27a-3p FZD4 -0.0713791016390708 0.936296470694396 0.0304707076358319 0.955399406040093 miRNATAP -0.332335163103274 6.55789467955252e-10 hsa-miR-27a-3p DKK2 -0.0713791016390708 0.936296470694396 0.299403293390667 0.169274319749997 miRNATAP -0.243059240523354 7.10890941131857e-05 hsa-miR-27a-3p PSEN1 -0.0713791016390708 0.936296470694396 -0.0685344526261558 0.908564158711858 miRNATAP -0.0510741305634187 0.00954957832772348 hsa-miR-27a-3p DAAM1 -0.0713791016390708 0.936296470694396 -0.0539991515887506 0.906596879539895 miRNATAP -0.214645452354381 2.10218326613165e-06 hsa-miR-539-5p AXIN1 -0.223963250948171 0.453655442416551 -0.0653528137130222 0.894667807615627 miRNATAP -0.162890931040002 4.17509848174996e-25 hsa-miR-185-5p GSK3B 0.0659414824247602 0.896134370932431 -0.0660851428212252 0.908304623747486 miRNATAP -0.0963777931238746 0.000344624808920585 hsa-miR-9-5p CSNK1A1 0.513826958284847 0.574325590140814 -0.0165042555609478 0.982452723332151 miRNATAP -0.0558643301761802 9.28387175183763e-13 hsa-miR-378c VANGL1 -0.184137739257534 0.443438540983173 -0.0952455706302153 0.850760454545912 miRNATAP -0.13496008439357 3.32243434568058e-11 hsa-miR-22-5p BTRC -0.282351613070713 0.500015990730185 -0.113796391872094 0.818463431452382 miRNATAP -0.169967299467369 1.97069244765403e-11 hsa-miR-28-5p SMAD3 -0.212713060051394 0.714914931441106 -0.00805727245311783 0.987902560465751 miRNATAP -0.120097254990824 0.00200641803458376 hsa-miR-182-5p TCF7L2 -0.101509746042318 0.939206381321837 -0.151922190442888 0.739870566881007 miRNATAP -0.285458372953323 5.15013518210834e-29 hsa-miR-30c-5p WNT7B -0.268052278300344 0.753220585849573 0.203059513313665 0.583576542147028 miRNATAP -0.455544291260138 2.11209121770824e-09 hsa-miR-30c-5p PRICKLE1 -0.268052278300344 0.753220585849573 -0.101221821514089 0.815959595958142 miRNATAP -0.185707414237874 1.02763767207438e-05 hsa-miR-92a-3p JUN -0.0230307937945682 0.984317735692711 -0.108657195258627 0.877583083771737 miRNATAP -0.138285339206201 0.00119119178853874 hsa-miR-92a-3p FZD10 -0.0230307937945682 0.984317735692711 -0.157448402775842 0.382566977418384 miRNATAP -0.296950048447328 5.92314304840851e-07 hsa-miR-92a-3p DAAM1 -0.0230307937945682 0.984317735692711 -0.0539991515887506 0.906596879539895 miRNATAP -0.0861349336422912 0.0320251519574902 hsa-miR-660-5p CXXC4 0.0681681272574144 0.880554662781555 -0.189634120723988 0.402205830601326 miRNATAP -0.558306258370776 2.42822704122193e-19 hsa-miR-29a-3p NFATC4 -0.173904473376583 0.873886834369773 0.118767632463774 0.80554796605913 miRNATAP -0.159424686343472 0.00138862402245239 hsa-miR-29a-3p GSK3B -0.173904473376583 0.873886834369773 -0.0660851428212252 0.908304623747486 miRNATAP -0.20395154397803 2.73691130456682e-19 hsa-miR-29a-3p FRAT2 -0.173904473376583 0.873886834369773 -0.0156891928833645 0.96774417787488 miRNATAP -0.0951788041223791 0.00101076471801923 hsa-miR-362-5p CAMK2B 0.215268517371166 0.469421708227034 0.141283778852512 0.60471522191955 miRNATAP -0.373141196834054 2.76360587755669e-09 hsa-miR-362-5p GSK3B 0.215268517371166 0.469421708227034 -0.0660851428212252 0.908304623747486 miRNATAP -0.0685099500989796 1.66662882833992e-05 hsa-miR-505-3p WNT7B -0.245807419731662 0.59093461248251 0.203059513313665 0.583576542147028 miRNATAP -0.25367826265264 7.46180280225906e-06 hsa-miR-15a-5p LRP6 0.027476192963463 0.965257307327948 -0.261612069159627 0.621254118198097 miRNATAP -0.248475041752213 6.11710404479044e-12 hsa-miR-15a-5p SIAH1 0.027476192963463 0.965257307327948 -0.105259829109209 0.810276326122422 miRNATAP -0.119160033954367 1.42207849374965e-07 hsa-miR-15a-5p PPP2R5C 0.027476192963463 0.965257307327948 -0.0241791959006408 0.968345143230327 miRNATAP -0.0676333071712333 8.70276795999836e-05 hsa-miR-15a-5p PPP3CB 0.027476192963463 0.965257307327948 0.0212980346837259 0.969289216388387 miRNATAP -0.126089090631579 8.14069089424982e-09 hsa-miR-432-5p GSK3B -0.206817222859276 0.428192312627123 -0.0660851428212252 0.908304623747486 miRNATAP -0.0626816970821618 6.82333172986177e-05 hsa-miR-185-3p NKD2 -0.0609325092037492 0.780830371804221 0.121258128388302 0.63474965799198 miRNATAP -0.0987209276985892 0.032615961939896 hsa-miR-125b-5p DVL3 -0.0598851546678105 0.945288350565791 0.00975763465514845 0.987406911304736 miRNATAP -0.0908411522451584 6.95717762665195e-13 hsa-miR-450b-5p SKP1 0.140781738083346 0.700777724167455 0.11984894684252 0.870895899955478 miRNATAP -0.0607116247078892 0.00058405407540698 hsa-miR-450b-5p NFAT5 0.140781738083346 0.700777724167455 -0.140634566870934 0.80102714017311 miRNATAP -0.0534618690394758 0.0303122740810065 hsa-miR-450b-5p APC 0.140781738083346 0.700777724167455 -0.0723635628413355 0.883189867616246 miRNATAP -0.0538079020449331 0.0300409631288848 hsa-miR-194-5p NFAT5 -0.0985657553098873 0.88041455080541 -0.140634566870934 0.80102714017311 miRNATAP -0.127013805342984 0.000142318500250381 hsa-miR-194-5p DAAM1 -0.0985657553098873 0.88041455080541 -0.0539991515887506 0.906596879539895 miRNATAP -0.189174045503208 3.95432785140071e-05 hsa-miR-194-5p FZD5 -0.0985657553098873 0.88041455080541 -0.186395173219289 0.518902590417545 miRNATAP -0.178831539257334 6.90395730167637e-05 hsa-miR-194-5p PRICKLE2 -0.0985657553098873 0.88041455080541 0.0177255412987654 0.969497997086328 miRNATAP -0.291494776067705 3.80032824411756e-09 hsa-let-7e-5p CCND2 0.0357092208790988 0.968612511131967 -0.168931301767903 0.722558871099741 miRNATAP -0.168033346737038 0.000309648297817392 hsa-let-7e-5p PLCB4 0.0357092208790988 0.968612511131967 0.0386799314732373 0.922546084561183 miRNATAP -0.194802452833621 0.0118202484022476 hsa-miR-130b-3p PLCB1 -0.211426879967744 0.486104856445712 0.16954029991043 0.64744751250053 miRNATAP -0.196209100856761 2.76427536384308e-05 hsa-miR-130b-3p MAPK10 -0.211426879967744 0.486104856445712 -0.469554749724375 0.0904444026222832 miRNATAP -0.311198542431805 1.15998229401123e-08 hsa-miR-130b-3p CXXC4 -0.211426879967744 0.486104856445712 -0.189634120723988 0.402205830601326 miRNATAP -0.23463521783126 4.93673028390429e-06 hsa-miR-454-3p PLCB1 -0.0807547300787816 0.779337172929459 0.16954029991043 0.64744751250053 miRNATAP -0.199095150598467 7.7170942260896e-06 hsa-miR-454-3p MAPK10 -0.0807547300787816 0.779337172929459 -0.469554749724375 0.0904444026222832 miRNATAP -0.269274577449595 2.23366460726875e-07 hsa-miR-107 MAPK8 -0.00374429919903285 0.994322461958742 -0.267537090166021 0.457115846208038 miRNATAP -0.17791631045835 3.75913999690967e-05 hsa-miR-107 FZD4 -0.00374429919903285 0.994322461958742 0.0304707076358319 0.955399406040093 miRNATAP -0.462830534136136 4.14785600961069e-16 hsa-miR-107 PPP3R1 -0.00374429919903285 0.994322461958742 -0.0271826487262787 0.962679518571233 miRNATAP -0.0636818082655454 0.00542700155076685 hsa-miR-27b-3p VANGL1 -0.113933322553999 0.889976675583125 -0.0952455706302153 0.850760454545912 miRNATAP -0.0924921022809419 0.0018912367143777 hsa-miR-27b-3p NLK -0.113933322553999 0.889976675583125 -0.0075726819422437 0.986090753913933 miRNATAP -0.115578430021538 2.04956118003642e-05 hsa-miR-27b-3p GSK3B -0.113933322553999 0.889976675583125 -0.0660851428212252 0.908304623747486 miRNATAP -0.0681569689001887 0.00296257678730039 hsa-miR-27b-3p APC -0.113933322553999 0.889976675583125 -0.0723635628413355 0.883189867616246 miRNATAP -0.08889292249061 0.00381818170237342 hsa-miR-16-5p FZD10 -0.131938295863899 0.869419037928521 -0.157448402775842 0.382566977418384 miRNATAP -0.205587202208207 0.000809635155549991 hsa-miR-191-5p FZD5 -0.264247937125955 0.760894795645613 -0.186395173219289 0.518902590417545 miRNATAP -0.0960943760585444 0.00375665527673952