miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7a-5p CSNK2A1 0.0597640130743571 0.956602708224938 -0.123923755647187 0.846001035315026 miRNAWalker2_validate;TargetScan -0.559342879897117 0.0387786729199846 hsa-let-7b-5p CSNK2A1 0.0207269980343128 0.98367842217083 -0.123923755647187 0.846001035315026 miRNAWalker2_validate -0.22094511046124 0.00389789705984094 hsa-let-7b-5p MYC 0.0207269980343128 0.98367842217083 0.325271241127012 0.702901712904038 miRNAWalker2_validate -0.518927223727951 0.0321030852695296 hsa-let-7b-5p NFATC3 0.0207269980343128 0.98367842217083 0.0130646585027367 0.983538056978343 miRNAWalker2_validate -0.139691423916933 0.0425234667599959 hsa-let-7c-5p CSNK2A1 0.17119830300334 0.867627766433077 -0.123923755647187 0.846001035315026 miRNAWalker2_validate -0.330615097666732 0.000103255907044644 hsa-let-7c-5p MYC 0.17119830300334 0.867627766433077 0.325271241127012 0.702901712904038 miRNAWalker2_validate;miRTarBase -0.60382968679973 0.0277246968993917 hsa-miR-101-3p FZD6 0.464328029948467 0.574675482004599 -0.0749791442525769 0.910124197712344 miRNAWalker2_validate;MirTarget -0.522340929910423 0.00135456038090646 hsa-miR-101-3p RAC1 0.464328029948467 0.574675482004599 -0.0413690220075456 0.963960955788999 miRNAWalker2_validate;MirTarget -0.132008926821801 0.0120055161713366 hsa-miR-146a-5p SMAD4 0.0384141252755779 0.965875415275784 0.0573140932660596 0.925986696410377 miRNAWalker2_validate;miRTarBase -0.086671168951349 0.00917673847429396 hsa-miR-155-5p PSEN1 0.173016289343062 0.841730842099713 0.0506826893627093 0.936176228149323 miRNAWalker2_validate -0.0943425108586691 0.0142724637229339 hsa-miR-155-5p SMAD3 0.173016289343062 0.841730842099713 0.0721641994766369 0.900684409314366 miRNAWalker2_validate -0.144351598235503 0.000158673049532907 hsa-miR-17-5p SMAD3 -0.0813163231702099 0.937998820269774 0.0721641994766369 0.900684409314366 miRNAWalker2_validate -0.225518120506561 0.0398455624976262 hsa-miR-186-5p CAMK2B -0.113248445647991 0.845183468616629 0.10319802149098 0.826287395232948 miRNAWalker2_validate;miRNATAP -0.102929398299313 0.00826103822653713 hsa-miR-18a-5p SMAD3 -0.282193580262938 0.699833081454104 0.0721641994766369 0.900684409314366 miRNAWalker2_validate -0.0903086745746396 0.0444263933384837 hsa-miR-192-5p FZD7 0.32180878131885 0.767162840151454 -0.242412314125248 0.590517145017364 miRNAWalker2_validate -0.861049188938166 1.11539517696614e-07 hsa-miR-192-5p VANGL1 0.32180878131885 0.767162840151454 -0.271579152400035 0.601038212424837 miRNAWalker2_validate -0.210299763701444 0.010872389809167 hsa-miR-193b-3p LEF1 0.0463868328052737 0.942794569416766 -0.102143737529688 0.840175399168525 miRNAWalker2_validate -0.159071038366017 0.0220474830127078 hsa-miR-193b-3p RAC2 0.0463868328052737 0.942794569416766 -0.0168879801279642 0.980133774739414 miRNAWalker2_validate -0.231307408750099 0.0197565241890046 hsa-miR-215-5p FZD7 0.293272387098842 0.777665131913364 -0.242412314125248 0.590517145017364 miRNAWalker2_validate -0.902903419175851 3.26624294366057e-07 hsa-miR-22-3p CSNK2A1 0.0956485801349309 0.917858267326681 -0.123923755647187 0.846001035315026 miRNAWalker2_validate -0.174190583556879 0.00774034006084155 hsa-miR-221-3p LRP6 -0.141431210644111 0.846363550451223 0.00823104729576229 0.990544813100733 miRNAWalker2_validate -0.0895690128375478 0.0367958919117244 hsa-miR-26b-5p RUVBL1 0.183264358662353 0.861384368119784 -0.11490585581265 0.866332365209168 miRNAWalker2_validate -0.495824732133521 0.00545180890337946 hsa-miR-30c-5p PLCB1 0.0423003593043454 0.965732696837528 -0.249240901797642 0.678577770817586 miRNAWalker2_validate -0.545530482650442 0.0125836456745422 hsa-miR-375 PRKCA -0.324490345738612 0.618049030392277 -0.0933570316766019 0.868553642112362 miRNAWalker2_validate -0.125620347140877 1.4972265342291e-05 23497265 The integrated analysis of miRNA and mRNA expression identified 35 known and novel target genes of miR-200c miR-205 and mir-375 including CFL2 LAMC1 TIMP2 ZEB1 CDH11 PRKCA PTPRJ PTPRM LDHB and SEC23A breast cancer hsa-miR-7-5p LRP6 -0.32199214916968 0.50638585858579 0.00823104729576229 0.990544813100733 miRNAWalker2_validate;miRNATAP -0.113522152332602 0.0381644443146146 hsa-miR-9-5p CCND1 -0.486251379638596 0.345933362496641 -0.218742902528161 0.753299650993788 miRNAWalker2_validate -0.314943038668035 0.00224027569448777 hsa-miR-92a-3p CCND1 -0.0952471340747607 0.921186141394209 -0.218742902528161 0.753299650993788 miRNAWalker2_validate -0.487310415278989 0.016013958307736 hsa-miR-92a-3p PRKCA -0.0952471340747607 0.921186141394209 -0.0933570316766019 0.868553642112362 miRNAWalker2_validate -0.184720547912782 0.0135381238074495 hsa-miR-92a-3p TBL1X -0.0952471340747607 0.921186141394209 -0.107405988221537 0.856427675894162 miRNAWalker2_validate;mirMAP -0.199670659379972 0.0474337224989675 hsa-miR-92a-3p WNT5A -0.0952471340747607 0.921186141394209 0.248754508617948 0.644773809978988 miRNAWalker2_validate -0.532307723547754 0.0455421151447197 hsa-miR-98-5p FZD10 0.113828146287672 0.884699547359262 0.156030526680958 0.665484349985084 miRNAWalker2_validate -0.189722241266368 0.0398724191063093 hsa-miR-135b-5p APC -0.485898309818435 0.295156399636844 0.0466907673951509 0.908936433168675 miRTarBase;MirTarget -0.133323309842864 0.0104912880875709 hsa-miR-203a-3p SMAD4 0.0534111530599723 0.930498891489609 0.0573140932660596 0.925986696410377 miRTarBase -0.0577595417608174 0.0421682323591305 hsa-miR-1-3p NFATC3 0.0136619427363467 0.981978774531911 0.0130646585027367 0.983538056978343 MirTarget -0.05825164561466 0.0470562912977576 hsa-miR-106b-5p CHP2 -0.0477650319888294 0.959547523649603 0.0176688315975078 0.970037605389583 MirTarget -0.151581851003777 0.0198250554599464 hsa-miR-125b-5p CSNK2A1 0.173213451621791 0.85693645798505 -0.123923755647187 0.846001035315026 MirTarget;miRNATAP -0.207164528831239 0.00105198474393884 hsa-miR-126-5p MAP3K7 0.144347802127632 0.882573949506442 -0.177231011811012 0.783192070809688 MirTarget -0.206246742934879 0.0371288334849453 hsa-miR-130b-3p FOSL1 -0.041478254258168 0.95918795095955 0.147571425242258 0.724616796376674 MirTarget -0.173013834478622 0.034622913429132 hsa-miR-138-5p CTNNBIP1 -0.0198281015104431 0.958421719812108 -0.0112514150471998 0.986376424614166 MirTarget -1.47295169728791 0.0426332783163995 hsa-miR-144-3p FZD6 0.680264220257598 0.411991670982838 -0.0749791442525769 0.910124197712344 MirTarget -0.273022756364149 0.00335410888478601 hsa-miR-145-5p CTNNBIP1 -0.143568612309084 0.865683527320636 -0.0112514150471998 0.986376424614166 MirTarget;miRNATAP -0.0862749803162281 0.0195613063369626 hsa-miR-146a-5p WNT3 0.0384141252755779 0.965875415275784 0.0353722777885155 0.942844083698833 MirTarget -0.082377722444542 0.0255471570427628 hsa-miR-146b-5p WNT3 0.163839472124934 0.861493303832822 0.0353722777885155 0.942844083698833 MirTarget;PITA;miRanda;miRNATAP -0.098715432737879 0.0137508076568227 hsa-miR-148a-3p PRKX 0.300409169118634 0.739894340643854 -0.306983476221361 0.476175486201207 MirTarget -0.168531752289811 0.0334266826775435 hsa-miR-149-5p BTRC 0.0217381519175435 0.955301546346375 -0.0488680634450889 0.922341767574627 MirTarget -0.217451305232199 0.00423099648209756 hsa-miR-152-3p SMAD2 0.0425721430034578 0.95577626241283 -0.0449736694694485 0.941844451114483 MirTarget -0.157584945518384 0.00638775066898202 hsa-miR-15a-5p WNT7A 0.0482767089535265 0.958674471552791 0.08879767083332 0.849910476645932 MirTarget -0.11324749289897 0.0190005989340543 hsa-miR-181c-5p TBL1X -0.0511850318355602 0.905207104352794 -0.107405988221537 0.856427675894162 MirTarget;miRNATAP -0.219225702727328 0.0436012478796837 hsa-miR-181c-5p WNT16 -0.0511850318355602 0.905207104352794 0.00618022833305787 0.983280446433131 MirTarget -0.075927247694533 0.000300304130339537 hsa-miR-194-5p PPP3CA 0.2970867089942 0.772916743754887 0.0262335763373098 0.969168179211646 MirTarget -0.255131819305092 0.00132007422303153 hsa-miR-195-5p BTRC 0.129014747377566 0.898850292883334 -0.0488680634450889 0.922341767574627 MirTarget;miRNATAP -0.0716453084420626 0.0225634076614677 23544130 Among the candidates we successfully identified CCNE1 CDC25A CCND3 CDK4 and BTRC as direct targets for miR-497 and miR-195 liver cancer hsa-miR-195-5p WNT7A 0.129014747377566 0.898850292883334 0.08879767083332 0.849910476645932 MirTarget -0.137724875589187 0.0223719968488658 hsa-miR-200a-3p PRKACB -0.174835122990172 0.800086915871665 0.0481486520682095 0.939593519492428 MirTarget;miRNATAP -0.133065592644019 0.00344659081506974 hsa-miR-200b-3p PRKACB -0.278140741287952 0.769279718690611 0.0481486520682095 0.939593519492428 MirTarget;TargetScan -0.091360570206676 0.0418375044461131 hsa-miR-203a-3p NLK 0.0534111530599723 0.930498891489609 0.0660301101082075 0.901915355233586 MirTarget -0.0757614700314039 0.0143631323022633 hsa-miR-204-5p TCF7L1 -0.103116138722697 0.838649168413988 -0.0357032814390363 0.951558752169444 MirTarget;miRNATAP -0.142512345640799 0.0100307372331762 hsa-miR-204-5p CCND2 -0.103116138722697 0.838649168413988 0.0628626833728685 0.89293975476861 MirTarget -0.0946819212020596 0.00856288765359214 hsa-miR-20a-5p CHP2 0.00546421403043418 0.995860817426392 0.0176688315975078 0.970037605389583 MirTarget -0.148691025380295 0.0413207173688522 hsa-miR-20b-5p CHP2 -0.0756609389577143 0.937180233832823 0.0176688315975078 0.970037605389583 MirTarget -0.192895157717597 0.00796855743988646 hsa-miR-218-5p NFATC3 0.0528956970657308 0.925768162461024 0.0130646585027367 0.983538056978343 MirTarget;miRNATAP -0.0832789968800096 0.0261739047062249 hsa-miR-222-3p SKP1 -0.290823078823493 0.717603926605052 0.127006377801415 0.861560763796685 MirTarget -0.0919883975835671 0.00971319184474712 hsa-miR-23a-3p CTNNBIP1 -0.0829387532989649 0.932450029930492 -0.0112514150471998 0.986376424614166 MirTarget;miRNATAP -0.220230052344917 0.0354641954438099 hsa-miR-24-3p WNT8B -0.0246508379418504 0.977609171890794 0.0870837314043893 0.863821162312938 MirTarget -0.158447498754628 0.0377510304984243 hsa-miR-25-3p CAMK2A -0.0567834739359405 0.949486553682602 0.00792082519671222 0.98729460460854 MirTarget -0.130094712939272 0.0443398268070239 hsa-miR-27b-3p PRKCB 0.0689984110845909 0.940227973828056 -0.0256848103205458 0.956000073839558 MirTarget;miRNATAP -0.316373532722131 0.0136999823795553 hsa-miR-30b-5p FZD3 0.028861699606507 0.977376032583464 -0.251002707845765 0.538543090300276 MirTarget -0.495507964131518 0.0026968288211062 hsa-miR-30c-5p FZD3 0.0423003593043454 0.965732696837528 -0.251002707845765 0.538543090300276 MirTarget;miRNATAP -0.392909734967157 0.0222387224418086 hsa-miR-30d-5p FZD3 -0.0431968596008367 0.966211409357874 -0.251002707845765 0.538543090300276 MirTarget;miRNATAP -0.274429322970161 0.00640330970284685 hsa-miR-331-3p TCF7 -0.137628228238804 0.767549629194538 -0.0106594576164731 0.984052051161805 MirTarget;miRNATAP -0.360994620807167 0.00178071698220893 hsa-miR-363-3p CAMK2A -0.288730073475614 0.606964126434905 0.00792082519671222 0.98729460460854 MirTarget -0.0588357912122252 0.0230645594273076 hsa-miR-424-5p WNT7A 0.0449157951940418 0.959473816285261 0.08879767083332 0.849910476645932 MirTarget -0.0771705330821902 0.0231449750100725 hsa-miR-452-5p DAAM1 -0.167004914856885 0.800132996544294 0.0871232463337295 0.884048631259874 MirTarget -0.14849069778873 0.0349658407776622 hsa-miR-484 NFATC4 -0.274220824462027 0.660072776804098 0.0734075926910212 0.885998683273429 MirTarget;miRNATAP -0.0754011842864009 0.0441413081451966 hsa-miR-488-5p CTNNBIP1 -0.000151039243550422 0.999683004209589 -0.0112514150471998 0.986376424614166 MirTarget -3.7120527277314 0.0158160250657696 hsa-miR-491-5p BTRC 0.0455328857607453 0.91381147995812 -0.0488680634450889 0.922341767574627 MirTarget;miRanda -0.133423328808084 0.00110450311544449 hsa-miR-491-5p TCF7 0.0455328857607453 0.91381147995812 -0.0106594576164731 0.984052051161805 MirTarget;PITA;miRanda;miRNATAP -0.603830939752933 0.000138395025125814 hsa-miR-495-3p FZD4 -0.139508239875013 0.73113738311162 0.183743851805126 0.757855081121629 MirTarget -0.143545791473926 0.0231415942474541 hsa-miR-497-5p AXIN2 0.200500374329086 0.778465510248254 -0.179878577412182 0.770556260101339 MirTarget;miRNATAP -0.285508591176116 0.00665779464593709 hsa-miR-497-5p WNT7A 0.200500374329086 0.778465510248254 0.08879767083332 0.849910476645932 MirTarget -0.0740297742394449 0.00614677513020319 hsa-miR-513a-5p CCND1 0.0226806349987836 0.954223977718823 -0.218742902528161 0.753299650993788 MirTarget -0.617924123039549 0.015313060219598 hsa-miR-520d-5p JUN -0.0420050819336231 0.918476252110319 -0.0161170258112548 0.980959109921939 MirTarget;PITA -0.405474430256433 0.032057650046511 hsa-miR-522-3p JUN -0.091509126648246 0.854527279143672 -0.0161170258112548 0.980959109921939 MirTarget;miRNATAP -0.137260097490356 0.0497263102763459 hsa-miR-93-5p CHP2 -0.178587796634709 0.846243000053125 0.0176688315975078 0.970037605389583 MirTarget -0.230648010786234 0.00597156107214519 hsa-miR-516a-5p CREBBP -0.262350406555391 0.617140836163887 -0.0308178472653395 0.960681597025619 PITA -0.0534014195158359 0.0197822513939896 hsa-miR-520d-5p CREBBP -0.0420050819336231 0.918476252110319 -0.0308178472653395 0.960681597025619 PITA -0.161299007445984 0.0252944032132611 hsa-miR-142-3p ROCK2 0.240611272664555 0.770128825361127 -0.0697933160037856 0.921461497705421 PITA;miRanda;miRNATAP -0.107636516833709 0.0251166786111494 hsa-miR-142-5p ROCK2 0.0548894250220364 0.947033269931482 -0.0697933160037856 0.921461497705421 PITA -0.127961307161129 0.0177336042521383 hsa-miR-142-5p SMAD3 0.0548894250220364 0.947033269931482 0.0721641994766369 0.900684409314366 PITA -0.157450893076999 0.000195569840876099 24558198 On TGF-β1 stimulation stable overexpression of miR-142-3p attenuated phosphorylation of SMAD3 an indispensable downstream effector in canonical TGF-β/Smad signaling via repression of TGFβR1 in A549 cells lung cancer hsa-miR-484 FZD4 -0.274220824462027 0.660072776804098 0.183743851805126 0.757855081121629 PITA -0.114902649808262 0.0251353314368928 hsa-miR-142-5p CAMK2A 0.0548894250220364 0.947033269931482 0.00792082519671222 0.98729460460854 PITA;miRNATAP -0.139183560805445 2.45426971737256e-07 hsa-miR-520a-3p CCND1 0.0439171541752934 0.910462893714847 -0.218742902528161 0.753299650993788 PITA;miRanda;miRNATAP -1.6466354733165 0.0164502170206585 hsa-miR-17-5p FZD4 -0.0813163231702099 0.937998820269774 0.183743851805126 0.757855081121629 TargetScan -0.255116082542441 0.00225862569253009 hsa-miR-199a-5p MAPK9 0.0729443535812155 0.926510295936894 -0.139449721198908 0.834242404781181 miRanda -0.0633837800672854 0.0103529167446515 hsa-miR-199a-5p WIF1 0.0729443535812155 0.926510295936894 -0.96044007715347 0.0787038113758505 miRanda -0.257383118937824 0.0413804106061292 hsa-miR-129-5p FZD6 0.0118449691739109 0.975148509742787 -0.0749791442525769 0.910124197712344 miRanda -8.74477886605729 0.0139310803983752 hsa-miR-139-5p PLCB1 0.437231029617605 0.403482506467067 -0.249240901797642 0.678577770817586 miRanda -0.193630325591877 0.0131775536186713 hsa-miR-139-5p MAPK9 0.437231029617605 0.403482506467067 -0.139449721198908 0.834242404781181 miRanda -0.107434570520334 0.0347405275897242 hsa-miR-139-5p VANGL1 0.437231029617605 0.403482506467067 -0.271579152400035 0.601038212424837 miRanda -0.126315632770152 0.0217937573193941 hsa-miR-139-5p RBX1 0.437231029617605 0.403482506467067 -0.15953313052022 0.847900296454625 miRanda -0.130567548081568 0.0206564474928414 hsa-miR-199b-5p WNT7B -0.198389673955795 0.675014032090733 0.0417667351183972 0.940783937765249 miRanda;miRNATAP -0.0896251154000333 0.0270794584880069 hsa-miR-142-3p TCF7 0.240611272664555 0.770128825361127 -0.0106594576164731 0.984052051161805 miRanda -0.155478888463073 0.00404084853109158 hsa-miR-142-3p CER1 0.240611272664555 0.770128825361127 -0.0375166903652557 0.924138977713769 miRanda -0.0529434014637244 0.0317172149248117 hsa-miR-125a-5p TCF7 -0.414411331079512 0.61981301947111 -0.0106594576164731 0.984052051161805 miRanda -0.142240579625898 0.0259601713708401 hsa-miR-193a-3p DVL2 0.0850352012637794 0.882750776751518 -0.226559778841941 0.695410604790598 miRanda -0.144137918442568 0.0043444395787144 hsa-miR-206 DVL3 0.0287017410160306 0.958705819933208 -0.192217523316629 0.763873580934986 miRanda -0.0973766119083983 0.0104784110767693 hsa-miR-320a WNT8A -0.212497564381529 0.816685645804052 -0.00617093648616063 0.98760182177341 miRanda -0.0847631549414405 0.0264281634448401 hsa-miR-320a APC -0.212497564381529 0.816685645804052 0.0466907673951509 0.908936433168675 miRanda -0.246756297350309 0.00260290422475494 hsa-miR-34c-5p RUVBL1 -0.0237934775057207 0.950179426986541 -0.11490585581265 0.866332365209168 miRanda -1.46340089268968 0.0270969687328077 hsa-miR-375 CSNK2A2 -0.324490345738612 0.618049030392277 -0.174653854078768 0.778540047078594 miRanda -0.0501799505126455 0.0497968582183611 hsa-miR-375 DAAM1 -0.324490345738612 0.618049030392277 0.0871232463337295 0.884048631259874 miRanda -0.152560166523885 0.0260609030340256 hsa-miR-342-3p WIF1 -0.0658898524177349 0.941522333137791 -0.96044007715347 0.0787038113758505 miRanda -0.719491949188424 0.00898751534223846 hsa-miR-326 CREBBP -0.0107012729046287 0.977551143841592 -0.0308178472653395 0.960681597025619 miRanda -1.17359560497241 0.0337939787033305 hsa-miR-326 PRKACG -0.0107012729046287 0.977551143841592 0.03867518957097 0.929823364706835 miRanda -1.34684796148069 0.00904130981680468 hsa-miR-338-3p PPP2R5D -0.110198737288447 0.794894007794712 -0.0738492671143769 0.900711679087017 miRanda -0.205218121395949 0.0269067505446203 hsa-miR-338-3p PSEN1 -0.110198737288447 0.794894007794712 0.0506826893627093 0.936176228149323 miRanda -0.238298586073532 0.0325522038324216 hsa-miR-429 NKD1 -0.145373472962103 0.800152766997877 -0.185438242799643 0.746618954259285 miRanda;miRNATAP -0.293834911993469 0.0129281724869586 hsa-miR-429 AXIN2 -0.145373472962103 0.800152766997877 -0.179878577412182 0.770556260101339 miRanda -0.293802587584455 0.0186977873792882 hsa-miR-429 FOSL1 -0.145373472962103 0.800152766997877 0.147571425242258 0.724616796376674 miRanda;miRNATAP -0.196885277732852 0.0140704349737878 hsa-miR-491-5p WNT1 0.0455328857607453 0.91381147995812 -0.0113418060097716 0.975006098611716 miRanda -0.146348164325984 0.0093334230998913 hsa-miR-491-5p FZD9 0.0455328857607453 0.91381147995812 0.000513744031579222 0.999071535155188 miRanda -0.188057968275794 0.00696190735770964 hsa-miR-491-5p PRKCG 0.0455328857607453 0.91381147995812 0.0135217903072533 0.979082739446205 miRanda -0.136536661296835 0.0182939014016609 hsa-miR-491-5p WNT10B 0.0455328857607453 0.91381147995812 0.0546086823710539 0.923365980993488 miRanda -0.233531117966786 0.0133188180683389 hsa-miR-520e NFATC4 -0.17878447848293 0.682118073853178 0.0734075926910212 0.885998683273429 miRanda -0.102148645006378 0.0392376725997541 hsa-miR-520d-3p WNT1 -0.0905183549230655 0.836126773943188 -0.0113418060097716 0.975006098611716 miRanda -0.119361730885988 0.00742696889857264 hsa-miR-520d-3p NFATC4 -0.0905183549230655 0.836126773943188 0.0734075926910212 0.885998683273429 miRanda -0.128319459975378 0.0119742055506823 hsa-miR-543 PPP2R5E -0.281310623215204 0.487019300730577 0.102902864786405 0.876902376164379 miRanda;mirMAP -0.230422376327094 0.00282511140977947 hsa-miR-18a-5p CAMK2B -0.282193580262938 0.699833081454104 0.10319802149098 0.826287395232948 mirMAP -0.0903430454864673 0.000198660022998157 hsa-miR-18b-5p CAMK2B -0.250381995498273 0.729891798124393 0.10319802149098 0.826287395232948 mirMAP -0.0905668203299136 0.000360283735335138 hsa-miR-181b-5p LRP6 -0.148764365880968 0.827930840010214 0.00823104729576229 0.990544813100733 mirMAP -0.0964482429809324 0.035755563905169 hsa-miR-618 LRP6 -0.0541383621781657 0.887979475212383 0.00823104729576229 0.990544813100733 mirMAP -0.699249283107389 0.016524158408604 hsa-miR-181a-5p CSNK2A2 -0.00862965738598831 0.99060227761518 -0.174653854078768 0.778540047078594 mirMAP -0.0817705254302259 0.0228664352681877 hsa-miR-30b-5p CSNK2A2 0.028861699606507 0.977376032583464 -0.174653854078768 0.778540047078594 mirMAP -0.259261179876108 0.0261682169726347 hsa-miR-30c-5p CSNK2A2 0.0423003593043454 0.965732696837528 -0.174653854078768 0.778540047078594 mirMAP -0.26291135148343 0.0285572318675986 hsa-miR-10a-5p CAMK2A -0.050505395399874 0.954468367878182 0.00792082519671222 0.98729460460854 mirMAP -0.143843825991803 0.000357197204829895 hsa-miR-185-5p CAMK2A -0.0918508578154889 0.894968104844075 0.00792082519671222 0.98729460460854 mirMAP -0.0943057285736508 0.0443638674904068 hsa-miR-27a-3p CAMK2A 0.0294459401420468 0.974813662554357 0.00792082519671222 0.98729460460854 mirMAP;miRNATAP -0.16389544125984 0.00673015248299287 hsa-miR-139-5p GSK3B 0.437231029617605 0.403482506467067 -0.0627205961267148 0.908286925122529 mirMAP -0.0788696063555399 0.0196984893929035 hsa-miR-26b-5p CSNK2A1 0.183264358662353 0.861384368119784 -0.123923755647187 0.846001035315026 mirMAP -0.251685854918007 0.0452007064135984 hsa-miR-105-5p TBL1X 0.0100375375932025 0.978959674884763 -0.107405988221537 0.856427675894162 mirMAP -1.53704456284723 0.0269551931718449 hsa-miR-130b-3p FZD3 -0.041478254258168 0.95918795095955 -0.251002707845765 0.538543090300276 mirMAP -0.131299542148068 0.00808047198195861 hsa-miR-145-5p FZD3 -0.143568612309084 0.865683527320636 -0.251002707845765 0.538543090300276 mirMAP -0.103724698525405 0.0319891464016479 hsa-miR-200b-3p FZD3 -0.278140741287952 0.769279718690611 -0.251002707845765 0.538543090300276 mirMAP -0.0728349286924536 0.049347599399755 hsa-miR-449a PPARD 0.0126201739512251 0.973683939983402 -0.156777584409785 0.782841788762955 mirMAP -0.464637948006036 0.0226573363904584 hsa-miR-28-5p APC2 0.0416959697875754 0.96180025613806 0.0581992041055157 0.907724058126313 mirMAP -0.104932285056483 0.0420116865350138 hsa-miR-324-3p APC2 -0.0979779294907379 0.820683785118461 0.0581992041055157 0.907724058126313 mirMAP -0.127383343006928 0.0119927256583764 hsa-miR-485-5p NKD2 0.00934815832117142 0.980775886050457 -0.0271592178108957 0.956253693739503 mirMAP -0.400096465418484 0.0218800449934825 hsa-miR-182-5p DAAM2 -0.529428194324166 0.494545320793065 0.214640026742627 0.688386495952727 mirMAP -0.0670814435237385 0.0361465098592073 hsa-miR-142-5p PRKCA 0.0548894250220364 0.947033269931482 -0.0933570316766019 0.868553642112362 mirMAP -0.194054205119687 3.9536155074771e-08 hsa-miR-146a-5p PRKCA 0.0384141252755779 0.965875415275784 -0.0933570316766019 0.868553642112362 mirMAP -0.164374497435934 9.75097057275355e-05 hsa-miR-150-5p PRKCA 0.053210970801123 0.947121943558373 -0.0933570316766019 0.868553642112362 mirMAP -0.121365059845485 5.7660956251329e-06 hsa-miR-181a-5p PRKCA -0.00862965738598831 0.99060227761518 -0.0933570316766019 0.868553642112362 mirMAP -0.208589839684775 1.79972818777265e-07 hsa-miR-181b-5p PRKCA -0.148764365880968 0.827930840010214 -0.0933570316766019 0.868553642112362 mirMAP -0.198063872669782 5.46545177962789e-07 hsa-miR-181c-5p PRKCA -0.0511850318355602 0.905207104352794 -0.0933570316766019 0.868553642112362 mirMAP -0.348125733854453 7.23227005175871e-06 hsa-miR-214-3p PRKCA -0.0100182276663778 0.990167078124911 -0.0933570316766019 0.868553642112362 mirMAP -0.0704310126734005 0.00479983166521706 hsa-miR-218-5p PRKCA 0.0528956970657308 0.925768162461024 -0.0933570316766019 0.868553642112362 mirMAP -0.112537239648465 0.00386380258948043 hsa-miR-452-5p PRKCA -0.167004914856885 0.800132996544294 -0.0933570316766019 0.868553642112362 mirMAP -0.0642638953862887 0.0381858704318652 hsa-miR-449a CTBP1 0.0126201739512251 0.973683939983402 0.014655158782551 0.984657722333606 mirMAP -0.869111281238752 0.000192650933590955 hsa-miR-26b-5p PRKCB 0.183264358662353 0.861384368119784 -0.0256848103205458 0.956000073839558 mirMAP -0.783384421761718 8.60737665905156e-06 hsa-miR-30c-5p PRKCB 0.0423003593043454 0.965732696837528 -0.0256848103205458 0.956000073839558 mirMAP -0.51530156877287 0.0206113792875153 hsa-miR-335-5p PRKCB 0.164145186697857 0.865283879919953 -0.0256848103205458 0.956000073839558 mirMAP -0.279677090505724 0.00252465243510136 hsa-miR-143-3p SMAD3 -0.0234010236687787 0.978202985944011 0.0721641994766369 0.900684409314366 mirMAP -0.0966531899777247 0.0443502603471686 hsa-miR-21-5p CXXC4 0.031977062924641 0.975460410437136 -0.0610123256916939 0.882813292447156 mirMAP -0.138033380640021 0.0395662711721259 hsa-miR-132-3p FZD4 -0.171734018323678 0.740950259318827 0.183743851805126 0.757855081121629 mirMAP -0.126488845853524 0.00489929864148757 hsa-miR-212-3p FZD4 -0.089635235845666 0.815336417986601 0.183743851805126 0.757855081121629 mirMAP -0.372733379399905 0.0364351918526556 hsa-miR-92a-3p FZD4 -0.0952471340747607 0.921186141394209 0.183743851805126 0.757855081121629 mirMAP -0.230786224924065 0.000374735433259895 hsa-miR-101-3p SMAD2 0.464328029948467 0.574675482004599 -0.0449736694694485 0.941844451114483 mirMAP -0.0946742039623634 0.0487163190629876 hsa-miR-144-3p SMAD2 0.680264220257598 0.411991670982838 -0.0449736694694485 0.941844451114483 mirMAP -0.0547126548849605 0.0449354092923925 hsa-miR-146b-5p SMAD2 0.163839472124934 0.861493303832822 -0.0449736694694485 0.941844451114483 mirMAP -0.101251296980137 0.0270930324535237 hsa-miR-26b-5p SMAD2 0.183264358662353 0.861384368119784 -0.0449736694694485 0.941844451114483 mirMAP -0.22642002193811 0.0462204376730242 hsa-miR-518f-3p JUN -0.194399943329347 0.687475310867432 -0.0161170258112548 0.980959109921939 mirMAP -0.143374702287428 0.0463079448517128 hsa-miR-125a-5p CTNNBIP1 -0.414411331079512 0.61981301947111 -0.0112514150471998 0.986376424614166 mirMAP -0.0747394989855221 0.041475661426312 hsa-miR-10a-5p WNT7B -0.050505395399874 0.954468367878182 0.0417667351183972 0.940783937765249 mirMAP -0.120428245189917 0.00309569653910886 hsa-miR-24-3p WNT7B -0.0246508379418504 0.977609171890794 0.0417667351183972 0.940783937765249 mirMAP -0.13311553935039 0.0413797665864436 hsa-miR-491-5p WNT7B 0.0455328857607453 0.91381147995812 0.0417667351183972 0.940783937765249 mirMAP -0.173245750301106 0.0223580238718254 hsa-miR-512-3p WNT7B -0.165471676137439 0.744177142210536 0.0417667351183972 0.940783937765249 mirMAP -0.0783730319833208 0.00669313682218502 hsa-miR-520a-5p WNT7B -0.0710020712237958 0.874001200847181 0.0417667351183972 0.940783937765249 mirMAP -0.130172586848904 0.00622882301738581 hsa-miR-522-3p WNT7B -0.091509126648246 0.854527279143672 0.0417667351183972 0.940783937765249 mirMAP -0.0833137221812211 0.00692463880097605 hsa-miR-525-5p WNT7B -0.168897907236313 0.725552336337227 0.0417667351183972 0.940783937765249 mirMAP -0.0832865252338749 0.0136735864487962 hsa-miR-515-5p NFATC4 -0.140008748116981 0.732693892391597 0.0734075926910212 0.885998683273429 miRNATAP -0.122481470095294 0.0247656330215474 hsa-miR-496 FZD4 -0.0177204556728094 0.962870004895999 0.183743851805126 0.757855081121629 miRNATAP -0.919109905086584 0.0334587239119491 hsa-miR-375 WNT5A -0.324490345738612 0.618049030392277 0.248754508617948 0.644773809978988 miRNATAP -0.274538554311774 0.00973097916758314 hsa-miR-32-5p FZD10 0.0527539877574643 0.943833686893932 0.156030526680958 0.665484349985084 miRNATAP -0.170839827370178 0.0141859023403522 hsa-let-7b-5p MAPK9 0.0207269980343128 0.98367842217083 -0.139449721198908 0.834242404781181 miRNATAP -0.224531805840187 0.00162676656048055 hsa-miR-30a-5p PPP3CB 0.116828674075915 0.870443465420305 -0.0154946159176967 0.981774473418877 miRNATAP -0.190713771617589 0.0139010549125375 hsa-miR-525-5p FOSL1 -0.168897907236313 0.725552336337227 0.147571425242258 0.724616796376674 miRNATAP -0.21613255362191 0.0150165979666944 hsa-miR-20b-5p SMAD4 -0.0756609389577143 0.937180233832823 0.0573140932660596 0.925986696410377 miRNATAP -0.140137525771653 0.039118814621109 hsa-miR-218-5p PPP2R5D 0.0528956970657308 0.925768162461024 -0.0738492671143769 0.900711679087017 miRNATAP -0.150679745580369 2.22382685201842e-05 hsa-miR-10a-5p CAMK2B -0.050505395399874 0.954468367878182 0.10319802149098 0.826287395232948 miRNATAP -0.0819183537156998 0.0178044638197029 hsa-miR-324-3p FZD9 -0.0979779294907379 0.820683785118461 0.000513744031579222 0.999071535155188 miRNATAP -0.138492632052538 0.03048351500769 hsa-miR-124-3p LRP6 0.00595671438154888 0.987498145456856 0.00823104729576229 0.990544813100733 miRNATAP -5.06424482152584 0.0322806478356554 hsa-miR-222-3p MAPK10 -0.290823078823493 0.717603926605052 0.0120138472736349 0.977542735212338 miRNATAP -0.062970777976536 0.00877589625178211 hsa-miR-221-3p MAPK10 -0.141431210644111 0.846363550451223 0.0120138472736349 0.977542735212338 miRNATAP -0.058442085240265 0.00723922613239073 hsa-miR-498 CREBBP 0.0256389159969101 0.947319641965808 -0.0308178472653395 0.960681597025619 miRNATAP -0.246883336913769 0.0496384162993161 hsa-miR-212-3p TCF7L2 -0.089635235845666 0.815336417986601 0.114804909456941 0.865069068578418 miRNATAP -0.649224286718613 0.00445546226725668 hsa-miR-150-5p FZD4 0.053210970801123 0.947121943558373 0.183743851805126 0.757855081121629 miRNATAP -0.0528388725349654 0.0326953525955632 hsa-miR-150-5p PPP2CB 0.053210970801123 0.947121943558373 0.0616906870862968 0.918463456446086 miRNATAP -0.0676658305826286 0.00743747517509039 hsa-miR-34a-5p PLCB1 0.273178528252193 0.656657511582639 -0.249240901797642 0.678577770817586 miRNATAP -0.171099685590866 0.00806284655197954 hsa-miR-26a-5p PLCB1 0.0472155737895648 0.96356055335446 -0.249240901797642 0.678577770817586 miRNATAP -0.703747352185405 0.0238406374155764 hsa-miR-26a-5p CAMK2A 0.0472155737895648 0.96356055335446 0.00792082519671222 0.98729460460854 miRNATAP -0.326936556319709 0.0321714732024696 hsa-miR-183-5p PRKCA -0.2195159338841 0.734570069472963 -0.0933570316766019 0.868553642112362 miRNATAP -0.0551394227124435 0.0496896092337845 hsa-miR-200c-3p PRKCA -0.43666375277625 0.59242252306256 -0.0933570316766019 0.868553642112362 miRNATAP -0.0756110339143198 0.0384482028376616 23497265 The integrated analysis of miRNA and mRNA expression identified 35 known and novel target genes of miR-200c miR-205 and mir-375 including CFL2 LAMC1 TIMP2 ZEB1 CDH11 PRKCA PTPRJ PTPRM LDHB and SEC23A breast cancer hsa-miR-26b-5p PLCB1 0.183264358662353 0.861384368119784 -0.249240901797642 0.678577770817586 miRNATAP -0.619924249229894 0.000462916890363413 hsa-miR-20a-5p FZD4 0.00546421403043418 0.995860817426392 0.183743851805126 0.757855081121629 miRNATAP -0.181131219467411 0.0189892884657447 hsa-miR-429 DAAM2 -0.145373472962103 0.800152766997877 0.214640026742627 0.688386495952727 miRNATAP -0.129146703264888 0.031137750322398 hsa-miR-10b-5p CAMK2B -0.346423180564974 0.69442278302903 0.10319802149098 0.826287395232948 miRNATAP -0.0678717128654488 0.00108020768457461 hsa-miR-15b-5p FZD10 -0.282204824210117 0.740121022506965 0.156030526680958 0.665484349985084 miRNATAP -0.270245577907797 0.0330022468039783 hsa-miR-513a-5p FZD4 0.0226806349987836 0.954223977718823 0.183743851805126 0.757855081121629 miRNATAP -0.197627204367512 0.0177826277002833 hsa-miR-519c-3p SMAD4 -0.0560644225337219 0.894775205374639 0.0573140932660596 0.925986696410377 miRNATAP -0.119496018119022 0.0498090386591563 hsa-miR-92a-3p JUN -0.0952471340747607 0.921186141394209 -0.0161170258112548 0.980959109921939 miRNATAP -0.271263359048873 0.033245465271176 hsa-miR-92a-3p DAAM1 -0.0952471340747607 0.921186141394209 0.0871232463337295 0.884048631259874 miRNATAP -0.439613037751046 0.00957625807417802 hsa-miR-520a-5p FOSL1 -0.0710020712237958 0.874001200847181 0.147571425242258 0.724616796376674 miRNATAP -0.32051796310315 0.010643454091431 hsa-miR-362-5p CAMK2B -0.472116006606457 0.387498676957069 0.10319802149098 0.826287395232948 miRNATAP -0.0941682366697715 0.0045466010753848 hsa-miR-15a-5p FZD10 0.0482767089535265 0.958674471552791 0.156030526680958 0.665484349985084 miRNATAP -0.396056210612665 0.000374745402577187 hsa-miR-125b-5p PLCB1 0.173213451621791 0.85693645798505 -0.249240901797642 0.678577770817586 miRNATAP -0.38460724071524 1.62472227795509e-05 hsa-miR-194-5p FZD3 0.2970867089942 0.772916743754887 -0.251002707845765 0.538543090300276 miRNATAP -0.20842778035207 0.0193525653594908 hsa-miR-194-5p PRKCB 0.2970867089942 0.772916743754887 -0.0256848103205458 0.956000073839558 miRNATAP -0.250074123447217 0.0307233932991835 hsa-let-7e-5p MAPK9 -0.324227293325611 0.661723422233116 -0.139449721198908 0.834242404781181 miRNATAP -0.128192426032912 0.00722174486703585 hsa-miR-16-5p FZD10 0.0452808700888117 0.9670611180163 0.156030526680958 0.665484349985084 miRNATAP -1.36976083829985 0.00528502544357897 hsa-miR-512-5p CTNNBIP1 0.0118718176101478 0.975276097533711 -0.0112514150471998 0.986376424614166 miRNATAP -1.53187908325627 0.0260218455175014