miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-140-5p ABCC9 0.844753502512594 3.73722278438606e-05 -2.75876018125141 1.07393305724125e-11 miRanda -0.194834716439971 0.0483680133616761 NA NA NA hsa-miR-152-3p ABCD3 -0.0480232621705712 0.844347735441565 0.143028791773986 0.526090946208158 MirTarget -0.175258467833865 8.60893061730299e-05 NA NA NA hsa-miR-140-5p ABLIM1 0.844753502512594 3.73722278438606e-05 -1.71611904526736 4.39382414807208e-10 PITA;miRanda -0.236316417146644 0.000357654505594004 NA NA NA hsa-miR-140-5p ACACA 0.844753502512594 3.73722278438606e-05 -0.159891059585386 0.292479723779159 miRanda -0.165647564995797 3.01087167120978e-06 NA NA NA hsa-miR-34a-5p ACSL4 1.9016323452565 1.43092834643601e-14 -0.411111056706694 0.0792024620124044 miRNAWalker2_validate;MirTarget;miRNATAP -0.128213325285489 0.0039931548042601 NA NA NA hsa-miR-194-5p ACTR3 1.8992998339217 3.76507853301977e-10 -0.048273548822209 0.716436322600754 mirMAP -0.110081984870106 6.98189853450182e-08 NA NA NA hsa-miR-140-5p ADAM10 0.844753502512594 3.73722278438606e-05 0.673280532227232 0.00766169587340031 MirTarget;PITA;miRanda -0.122033210228588 0.0417606710378131 NA NA NA hsa-miR-34a-5p ADAM22 1.9016323452565 1.43092834643601e-14 -1.1208957204799 0.0258901538153152 MirTarget;miRNATAP -0.32258929423001 0.000752607872842454 NA NA NA hsa-miR-140-5p ADAM9 0.844753502512594 3.73722278438606e-05 -0.201341592129357 0.406653935441953 PITA;miRanda;miRNATAP -0.210178852540258 0.000230079799918199 NA NA NA hsa-miR-152-3p ADAMTS19 -0.0480232621705712 0.844347735441565 -2.9931292116329 1.24985264052611e-06 MirTarget -0.65383094080489 1.08289339967678e-07 NA NA NA hsa-miR-34a-5p ADAMTS2 1.9016323452565 1.43092834643601e-14 -0.765859613535112 0.157626581795504 MirTarget -0.533315763603956 1.700855856725e-07 NA NA NA hsa-miR-194-5p ADAMTS5 1.8992998339217 3.76507853301977e-10 -2.15722764151586 2.79015119071511e-11 mirMAP -0.256631299312528 6.04038336864906e-07 NA NA NA hsa-miR-34a-5p ADARB1 1.9016323452565 1.43092834643601e-14 -1.92780468757935 3.75403498492562e-10 miRNAWalker2_validate -0.484223275855852 4.71093023246375e-17 NA NA NA hsa-miR-34a-5p AFAP1L2 1.9016323452565 1.43092834643601e-14 0.0579969442179609 0.858094386575771 miRNAWalker2_validate -0.177083707722149 0.00405690553043548 NA NA NA hsa-miR-34a-5p AFF4 1.9016323452565 1.43092834643601e-14 -0.822203744881362 6.4795364730311e-08 miRNATAP -0.107337753829631 0.000239606228511106 NA NA NA hsa-miR-140-5p AGAP1 0.844753502512594 3.73722278438606e-05 -0.404445587287753 0.0102055087274871 miRanda -0.123847583337213 0.000851786511617875 NA NA NA hsa-miR-34a-5p AHNAK 1.9016323452565 1.43092834643601e-14 -1.65511086697194 9.68769934496862e-10 miRNAWalker2_validate -0.299986348556079 6.84179254462737e-09 NA NA NA hsa-miR-140-5p AKAP11 0.844753502512594 3.73722278438606e-05 -0.801230576416459 1.137206260025e-06 MirTarget;miRanda -0.177663012583487 5.26876060812453e-06 NA NA NA hsa-miR-140-5p AKAP13 0.844753502512594 3.73722278438606e-05 -1.14731602724292 2.3511548631978e-13 miRanda -0.164008349347098 1.42493730502184e-05 NA NA NA hsa-miR-34a-5p AKAP13 1.9016323452565 1.43092834643601e-14 -1.14731602724292 2.3511548631978e-13 mirMAP -0.205865784904102 5.97230605691576e-12 NA NA NA hsa-miR-140-5p AKAP6 0.844753502512594 3.73722278438606e-05 -3.34363666302702 7.99165625683913e-15 miRanda -0.436169130691051 3.09501602131859e-05 NA NA NA hsa-miR-34a-5p AKAP6 1.9016323452565 1.43092834643601e-14 -3.34363666302702 7.99165625683913e-15 MirTarget -0.911486762786373 6.30919728561791e-31 NA NA NA hsa-miR-152-3p AKAP7 -0.0480232621705712 0.844347735441565 -1.25860380700641 1.06625080623197e-05 MirTarget -0.184688343268914 0.00129094390169391 NA NA NA hsa-miR-34a-5p ALCAM 1.9016323452565 1.43092834643601e-14 -0.727096079165627 0.0564724669785303 MirTarget;miRNATAP -0.178273936302345 0.0141825384017939 NA NA NA hsa-miR-194-5p ALDH1L2 1.8992998339217 3.76507853301977e-10 -1.11718715083506 0.024476208144821 mirMAP -0.622282110792 1.20458627185809e-16 NA NA NA hsa-miR-34a-5p ALDH1L2 1.9016323452565 1.43092834643601e-14 -1.11718715083506 0.024476208144821 MirTarget -0.665220566906835 5.64312376217526e-13 NA NA NA hsa-miR-34a-5p AMOTL2 1.9016323452565 1.43092834643601e-14 -1.01147657574476 0.000152881926388237 MirTarget -0.313272387060572 4.52925033838338e-10 NA NA NA hsa-miR-194-5p ANGPTL1 1.8992998339217 3.76507853301977e-10 -4.51343158742721 1.32318310475559e-13 MirTarget -0.723455627880745 3.74736913333874e-14 NA NA NA hsa-miR-34a-5p ANK2 1.9016323452565 1.43092834643601e-14 -4.31721795702785 2.30783903904989e-14 MirTarget;miRNATAP -0.918196061538051 9.9431973788018e-18 NA NA NA hsa-miR-140-5p ANK3 0.844753502512594 3.73722278438606e-05 -0.29125559007354 0.318956365911665 miRanda -0.201938740948823 0.00341430031187663 NA NA NA hsa-miR-140-5p ANKRD12 0.844753502512594 3.73722278438606e-05 -0.642312039340191 0.000117907490227554 miRanda -0.132725902985594 0.000789892686022049 NA NA NA hsa-miR-140-5p ANKRD17 0.844753502512594 3.73722278438606e-05 -0.0895075167623141 0.565465564707582 miRanda -0.123697266935072 0.000721188634533575 NA NA NA hsa-miR-140-5p ANKRD34A 0.844753502512594 3.73722278438606e-05 -0.408421591773803 0.0728223644541111 miRanda -0.148232488886101 0.00586258813341189 NA NA NA hsa-miR-140-5p ANKS1B 0.844753502512594 3.73722278438606e-05 -3.64577764939118 2.20146273204331e-13 miRanda -0.262068630581057 0.0307780559859258 NA NA NA hsa-miR-140-5p ANO6 0.844753502512594 3.73722278438606e-05 -0.735619951587254 2.77825363015957e-05 miRanda -0.165443769516454 6.91770602421735e-05 NA NA NA hsa-miR-34a-5p ANP32B 1.9016323452565 1.43092834643601e-14 0.0656649567967937 0.670726855548961 miRNATAP -0.11570029220005 7.13017612382934e-05 NA NA NA hsa-miR-34a-5p AP1S2 1.9016323452565 1.43092834643601e-14 -1.3126608153732 9.8644272412276e-09 MirTarget -0.427285958036978 2.11669116324457e-24 NA NA NA hsa-miR-34a-5p AR 1.9016323452565 1.43092834643601e-14 -3.30120233642072 7.57858237760738e-07 MirTarget -0.285552437081945 0.0268278531005963 24349627;22347519;21343391;25920548;25797256;23145211 In this study we found loss of miR-34a which targets AR in PCa tissue specimens especially in patients with higher Gleason grade tumors consistent with increased expression of AR; Most importantly BR-DIM intervention in PCa patients prior to radical prostatectomy showed reexpression of miR-34a which was consistent with decreased expression of AR PSA and Notch-1 in PCa tissue specimens; PCa cells treated with BR-DIM and 5-aza-dC resulted in the demethylation of miR-34a promoter concomitant with inhibition of AR and PSA expression in LNCaP and C4-2B cells; These results suggest for the first time epigenetic silencing of miR-34a in PCa which could be reversed by BR-DIM treatment and thus BR-DIM could be useful for the inactivation of AR in the treatment of PCa.This corrects the article on p;In this study we found loss of miR-34a which targets AR in PCa tissue specimens especially in patients with higher Gleason grade tumors consistent with increased expression of AR; Most importantly BR-DIM intervention in PCa patients prior to radical prostatectomy showed re-expression of miR-34a which was consistent with decreased expression of AR PSA and Notch-1 in PCa tissue specimens; PCa cells treated with BR-DIM and 5-aza-dC resulted in the demethylation of miR-34a promoter concomitant with inhibition of AR and PSA expression in LNCaP and C4-2B cells;In particular analysis of clinical prostate cancers confirmed a negative correlation of miR-34a and miR-34c expression with AR levels;To explore further the possible role of miRNAs in the AR pathway LNCaP cell line was treated with 5α-dihydrotestosterone and flutamide showing alteration in miRNAs expression especially miR-34a which was significantly underexpressed after treatment with high doses of 5α-dihydrotestosterone; Our data support a role for miRNAs especially miR-371 and miR-34a in the complex disarrangement of AR signaling pathway and in the behavior of PC;Repression of miR-34a a known AR-targeting miRNA contributes AR expression by XRN1;Inactivation of AR and Notch 1 signaling by miR 34a attenuates prostate cancer aggressiveness; We found that over-expression of miR-34a led to reduced expression of AR PSA and Notch-1; These findings suggest that the loss of miR-34a is directly linked with up-regulation of AR and Notch-1 both of which are highly expressed in PCa and thus finding innovative approaches by which miR-34a expression could be up-regulated will have a huge impact on the treatment of PCa especially for the treatment of mCRPC ;;;;; prostate cancer;prostate cancer;prostate cancer;prostate cancer;prostate cancer;prostate cancer hsa-miR-34a-5p ARHGAP1 1.9016323452565 1.43092834643601e-14 -0.882266671503522 1.75389981751782e-09 miRNAWalker2_validate;MirTarget;miRNATAP -0.176208226939718 2.42050605259084e-10 NA NA NA hsa-miR-194-5p ARHGAP21 1.8992998339217 3.76507853301977e-10 -0.232772292996588 0.204239002702133 MirTarget;miRNATAP -0.130893418876158 4.01603501227259e-06 NA NA NA hsa-miR-194-5p ARHGAP24 1.8992998339217 3.76507853301977e-10 -2.02152097141819 3.81745641239796e-10 miRNATAP -0.463896435657839 4.39333881795085e-21 NA NA NA hsa-miR-140-5p ARHGAP32 0.844753502512594 3.73722278438606e-05 0.684691543227815 0.00491963645957858 miRanda -0.161874135192085 0.00502012572707938 NA NA NA hsa-miR-140-5p ARHGEF4 0.844753502512594 3.73722278438606e-05 -1.4406738881977 0.0130992114003101 miRanda -0.48058816550587 0.000463502174098914 NA NA NA hsa-miR-140-5p ARIH1 0.844753502512594 3.73722278438606e-05 -0.409853463302452 0.000178637185009809 MirTarget;miRanda -0.116102297500156 6.0782470579805e-06 NA NA NA hsa-miR-152-3p ARL6IP1 -0.0480232621705712 0.844347735441565 0.960147486396201 9.53831526270758e-09 MirTarget -0.137115974598463 4.65165661659339e-05 NA NA NA hsa-miR-140-5p ARMC9 0.844753502512594 3.73722278438606e-05 -0.174093498391943 0.435015689310142 miRanda -0.127926108507163 0.0151398814821306 NA NA NA hsa-miR-140-5p ARSK 0.844753502512594 3.73722278438606e-05 -0.167682014660082 0.313355819108703 miRanda -0.100274279134322 0.0105559533120842 NA NA NA hsa-miR-194-5p ASAP1 1.8992998339217 3.76507853301977e-10 0.0593314983478699 0.779444757742406 MirTarget;miRNATAP -0.107848804021234 0.00108373201051941 NA NA NA hsa-miR-34a-5p ASB1 1.9016323452565 1.43092834643601e-14 -0.87000981136547 1.63208206880833e-08 MirTarget;miRNATAP -0.163788034088971 2.36991613382301e-08 NA NA NA hsa-miR-140-5p ASB5 0.844753502512594 3.73722278438606e-05 -6.18279002633771 6.12089777153688e-14 miRanda -0.985118762215287 7.51534651200944e-07 NA NA NA hsa-miR-140-5p ASH1L 0.844753502512594 3.73722278438606e-05 -0.665491082505517 0.00016245255837021 miRanda -0.260103399163736 2.55617754024952e-10 NA NA NA hsa-miR-34a-5p ASTN1 1.9016323452565 1.43092834643601e-14 -2.34091357321142 2.35607881846946e-05 MirTarget -0.252055030665196 0.0179657654863931 NA NA NA hsa-miR-140-5p ASXL2 0.844753502512594 3.73722278438606e-05 -0.51451006623666 0.0933931654074008 mirMAP -0.16356073752757 0.0242880500135544 NA NA NA hsa-miR-34a-5p ASXL2 1.9016323452565 1.43092834643601e-14 -0.51451006623666 0.0933931654074008 MirTarget -0.273330572468759 2.31955299766335e-06 NA NA NA hsa-miR-194-5p ATE1 1.8992998339217 3.76507853301977e-10 -1.08588499225057 2.80031137018061e-05 MirTarget -0.104856566433004 0.0103996198815416 NA NA NA hsa-miR-194-5p ATF2 1.8992998339217 3.76507853301977e-10 -0.360334142061557 0.0913687862766104 miRNATAP -0.107350599250521 0.00126943098471402 NA NA NA hsa-miR-194-5p ATL3 1.8992998339217 3.76507853301977e-10 -0.187603489371978 0.434299741872226 MirTarget -0.213733572185796 6.98567207670101e-09 NA NA NA hsa-miR-194-5p ATP8B4 1.8992998339217 3.76507853301977e-10 -1.9014588444487 1.51297048489511e-09 MirTarget -0.415860858210281 7.4128411015912e-18 NA NA NA hsa-miR-140-5p ATP9B 0.844753502512594 3.73722278438606e-05 -0.609823022909981 2.54906140909479e-05 miRanda -0.102071563421089 0.00301226870916766 NA NA NA hsa-miR-34a-5p AXIN2 1.9016323452565 1.43092834643601e-14 -1.6986287186272 5.56904404371908e-05 miRNAWalker2_validate;miRTarBase -0.316389522899683 8.52056660674017e-05 23624843 p53 regulates nuclear GSK 3 levels through miR 34 mediated Axin2 suppression in colorectal cancer cells; Exogenous miR-34a decreases Axin2 UTR-reporter activity through multiple binding sites within the 5' and 3' UTR of Axin2; Further RNA transcripts of miR-34 target were correlated with Axin2 in clinical data set of colorectal cancer patients colorectal cancer hsa-miR-34a-5p AXL 1.9016323452565 1.43092834643601e-14 -1.77455438864263 3.15266913146372e-06 miRNAWalker2_validate;miRTarBase;miRNATAP -0.539584011595936 3.50099212266538e-14 26667302;21814748;25895459 Negative feedback regulation of AXL by miR 34a modulates apoptosis in lung cancer cells; To clarify the role of miRNAs in this regulation loop approaches using bioinformatics and molecular techniques were applied revealing that miR-34a may target the 3' UTR of AXL mRNA to inhibit AXL expression; Therefore we propose that AXL is autoregulated by miR-34a in a feedback loop; this may provide a novel opportunity for developing AXL-targeted anticancer therapies;We identified human miR-34a expression as being >3-fold down from its median expression value across all cell lines in MDA-MB-231 cells and identified AXL as a putative mRNA target using multiple miRNA/target prediction algorithms; In reporter assays miR-34a binds to its putative target site within the AXL 3'UTR to inhibit luciferase expression; Finally we present an inverse correlative trend in miR-34a and AXL expression for both cell line and patient tumor samples;MiR 34a suppresses ovarian cancer proliferation and motility by targeting AXL; Overexpression of miR-34a led to the inhibition of AXL expression indicating that AXL is a target gene for miR-34a; Our data suggest that miR-34a may function as a tumor suppressor through repression of oncogenic AXL in ovarian cancer ;;motility lung cancer;breast cancer;ovarian cancer hsa-miR-140-5p BAG4 0.844753502512594 3.73722278438606e-05 0.137093299664976 0.558111215664814 miRanda -0.158479596785994 0.00409488937841221 NA NA NA hsa-miR-140-5p BAZ2B 0.844753502512594 3.73722278438606e-05 -0.74167431397335 2.56121329576771e-05 PITA;miRanda;miRNATAP -0.266033655055126 9.70798050467013e-11 NA NA NA hsa-miR-140-5p BBS4 0.844753502512594 3.73722278438606e-05 0.0217684666215772 0.874094648140218 miRanda -0.131448122113029 4.28878950798175e-05 NA NA NA hsa-miR-140-5p BBS9 0.844753502512594 3.73722278438606e-05 -0.329576656269687 0.0226602238993601 miRanda -0.141746970702157 2.93809417398351e-05 NA NA NA hsa-miR-140-5p BCHE 0.844753502512594 3.73722278438606e-05 -4.36955891405604 9.94951183281335e-13 miRanda -0.516913885029174 0.000508643579188105 NA NA NA hsa-miR-34a-5p BCL2 1.9016323452565 1.43092834643601e-14 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.313298897109154 6.78995714898249e-09 24565525;23155233;24444609;20687223;22623155;24988056;18803879;19714243;25053345;20433755;21399894;22964582;23862748 In vitro and in vivo experiments showed that miR-34a and DOX can be efficiently encapsulated into HA-CS NPs and delivered into tumor cells or tumor tissues and enhance anti-tumor effects of DOX by suppressing the expression of non-pump resistance and anti-apoptosis proto-oncogene Bcl-2;The miR-34a expression levels in cells after irradiation at 30 and 60 Gy were 0.17- and 18.7-times the BCL2 and caspase-9 expression levels respectively;Functional analyses further indicate that restoration of miR-34a inhibits B cell lymphoma-2 Bcl-2 protein expression to withdraw the survival advantage of these resistant NSCLC cells;Thus in PC3PR cells reduced expression of miR-34a confers paclitaxel resistance via up-regulating SIRT1 and Bcl2 expression; MiR-34a and its downstream targets SIRT1 and Bcl2 play important roles in the development of paclitaxel resistance all of which can be useful biomarkers and promising therapeutic targets for the drug resistance in hormone-refractory prostate cancer;MiR 34a inhibits proliferation and migration of breast cancer through down regulation of Bcl 2 and SIRT1; In this study we aimed to determine the effect of miR-34a on the growth of breast cancer and to investigate whether its effect is achieved by targeting Bcl-2 and SIRT1; Bcl-2 and SIRT1 as the targets of miR-34a were found to be in reverse correlation with ectopic expression of miR-34a;Target analysis indicated that micro RNA miR-34a directly regulates Bcl-2 and miR-34a overexpression decreased Bcl-2 protein level in gastric cancer cells; We also found that luteolin upregulates miR-34a expression and downregulates Bcl-2 expression; Based on these results we can draw the conclusion that luteolin partly decreases Bcl-2 expression through upregulating miR-34a expression;miR-34 targets Notch HMGA2 and Bcl-2 genes involved in the self-renewal and survival of cancer stem cells; Human gastric cancer cells were transfected with miR-34 mimics or infected with the lentiviral miR-34-MIF expression system and validated by miR-34 reporter assay using Bcl-2 3'UTR reporter; Human gastric cancer Kato III cells with miR-34 restoration reduced the expression of target genes Bcl-2 Notch and HMGA2; Bcl-2 3'UTR reporter assay showed that the transfected miR-34s were functional and confirmed that Bcl-2 is a direct target of miR-34; The mechanism of miR-34-mediated suppression of self-renewal appears to be related to the direct modulation of downstream targets Bcl-2 Notch and HMGA2 indicating that miR-34 may be involved in gastric cancer stem cell self-renewal/differentiation decision-making;Among the target proteins regulated by miR-34 are Notch pathway proteins and Bcl-2 suggesting the possibility of a role for miR-34 in the maintenance and survival of cancer stem cells; Our data support the view that miR-34 may be involved in pancreatic cancer stem cell self-renewal potentially via the direct modulation of downstream targets Bcl-2 and Notch implying that miR-34 may play an important role in pancreatic cancer stem cell self-renewal and/or cell fate determination;Manipulating miR-34a in prostate cancer cells confirms that this miRNA regulates BCL-2 and may in part regulate response to docetaxel;For instance miR-34a up-regulation corresponded with a down-regulation of BCL2 protein; Treating Par-4-overexpressing HT29 cells with a miR-34a antagomir functionally reversed both BCL2 down-regulation and apoptosis by 5-FU;Quantitative PCR and western analysis confirmed decreased expression of two genes BCL-2 and CCND1 in docetaxel-resistant cells which are both targeted by miR-34a;Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;MicroRNA 34a targets Bcl 2 and sensitizes human hepatocellular carcinoma cells to sorafenib treatment; HCC tissues with lower miR-34a expression displayed higher expression of Bcl-2 protein than those with high expression of miR-34a; therefore an inverse correlation is evident between the miR-34a level and Bcl-2 expression; Bioinformatics and luciferase reporter assays revealed that miR-34a binds the 3'-UTR of the Bcl-2 mRNA and represses its translation; Western blotting analysis and qRT-PCR confirmed that Bcl-2 is inhibited by miR-34a overexpression; Functional analyses indicated that the restoration of miR-34a reduced cell viability promoted cell apoptosis and potentiated sorafenib-induced apoptosis and toxicity in HCC cell lines by inhibiting Bcl-2 expression drug resistance;;poor survival;drug resistance;;;poor survival;differentiation;poor survival;drug resistance;;;; breast cancer;glioblastoma;lung squamous cell cancer;prostate cancer;breast cancer;gastric cancer;gastric cancer;pancreatic cancer;prostate cancer;colon cancer;breast cancer;lung cancer;liver cancer hsa-miR-140-5p BCL2L2 0.844753502512594 3.73722278438606e-05 -1.26677315930351 4.33863183081921e-14 PITA;miRanda;miRNATAP -0.201966784997366 5.91338344379721e-07 NA NA NA hsa-miR-140-5p BCL9 0.844753502512594 3.73722278438606e-05 0.123994115889714 0.478299662915324 MirTarget;PITA;miRanda;miRNATAP -0.162042447790352 7.78082991541625e-05 NA NA NA hsa-miR-152-3p BHLHE41 -0.0480232621705712 0.844347735441565 -0.068390854115945 0.864604357496866 MirTarget -0.500344031443618 1.6117637433296e-10 NA NA NA hsa-miR-194-5p BICD2 1.8992998339217 3.76507853301977e-10 -0.456668617144787 0.0137781672494013 miRNATAP -0.163510193354435 1.0763331072485e-08 NA NA NA hsa-miR-34a-5p BIRC3 1.9016323452565 1.43092834643601e-14 -1.14878434773067 0.00715931622274468 miRNAWalker2_validate -0.217054924716933 0.00780122048146313 NA NA NA hsa-miR-34a-5p BMP1 1.9016323452565 1.43092834643601e-14 0.194918683355282 0.453370270266782 mirMAP -0.153976655186265 0.00180202470782668 NA NA NA hsa-miR-152-3p BMP3 -0.0480232621705712 0.844347735441565 -0.537154432136997 0.56709126601337 MirTarget -1.1076922117479 1.63981049897959e-09 NA NA NA hsa-miR-140-5p BMPR1A 0.844753502512594 3.73722278438606e-05 -0.769696479269679 2.04474538839979e-07 miRanda -0.202151232698844 6.83112462517003e-09 NA NA NA hsa-miR-194-5p BNC1 1.8992998339217 3.76507853301977e-10 -0.289320031550416 0.775235902215072 MirTarget -1.13916845687987 1.45442448173029e-13 NA NA NA hsa-miR-34a-5p BNC2 1.9016323452565 1.43092834643601e-14 -2.95176911794991 3.46014802400024e-09 miRNATAP -0.803483970077456 6.98511511249094e-18 NA NA NA hsa-miR-194-5p BRMS1L 1.8992998339217 3.76507853301977e-10 -0.506070486086406 0.00391457381381874 MirTarget -0.187547314087577 2.72652888359352e-12 NA NA NA hsa-miR-152-3p BTAF1 -0.0480232621705712 0.844347735441565 -0.163756300418759 0.378274738702433 MirTarget -0.137224469531717 0.000190663716703478 NA NA NA hsa-miR-140-5p BTBD7 0.844753502512594 3.73722278438606e-05 -0.301289747681754 0.0314352639468306 PITA -0.167257337262869 3.04567451051162e-07 NA NA NA hsa-miR-34a-5p C17orf51 1.9016323452565 1.43092834643601e-14 -0.678914258700408 0.0225411911064938 mirMAP -0.246693819299922 1.19469908365641e-05 NA NA NA hsa-miR-194-5p C1orf21 1.8992998339217 3.76507853301977e-10 -1.50529673423141 7.359521051655e-11 mirMAP;miRNATAP -0.159921744377987 1.34455822711833e-05 NA NA NA hsa-miR-34a-5p C1orf21 1.9016323452565 1.43092834643601e-14 -1.50529673423141 7.359521051655e-11 mirMAP -0.221569550392997 6.54300469611722e-07 NA NA NA hsa-miR-34a-5p C3orf70 1.9016323452565 1.43092834643601e-14 -2.59753933038565 1.30307841273813e-11 miRNATAP -0.465045502913128 2.53133610277102e-10 NA NA NA hsa-miR-194-5p C6orf106 1.8992998339217 3.76507853301977e-10 -0.158081433754432 0.269139026322449 mirMAP -0.105175286190233 1.92267708719443e-06 NA NA NA hsa-miR-34a-5p C6orf106 1.9016323452565 1.43092834643601e-14 -0.158081433754432 0.269139026322449 miRNATAP -0.104320486580289 0.000111240295496594 NA NA NA hsa-miR-152-3p CABP7 -0.0480232621705712 0.844347735441565 0.928564890870204 0.0315719891917015 MirTarget -0.260264659540229 0.00250195912960863 NA NA NA hsa-miR-34a-5p CACHD1 1.9016323452565 1.43092834643601e-14 -1.73365174141046 9.53428068425233e-07 MirTarget -0.405935802364935 1.40008147843004e-09 NA NA NA hsa-miR-140-5p CACNA1C 0.844753502512594 3.73722278438606e-05 -2.53203105122136 8.2041496030931e-11 PITA;miRNATAP -0.342509206669341 0.00026923633766492 NA NA NA hsa-miR-34a-5p CACNA1C 1.9016323452565 1.43092834643601e-14 -2.53203105122136 8.2041496030931e-11 MirTarget -0.482930202130142 8.6203015431497e-11 NA NA NA hsa-miR-34a-5p CALD1 1.9016323452565 1.43092834643601e-14 -2.4663455628847 1.26294093745705e-11 miRNAWalker2_validate -0.73446754089701 2.61417639108455e-28 NA NA NA hsa-miR-34a-5p CAMK2B 1.9016323452565 1.43092834643601e-14 0.669901839915794 0.194250472530958 mirMAP -0.262724875681621 0.00749431352388259 NA NA NA hsa-miR-140-5p CAMK2N1 0.844753502512594 3.73722278438606e-05 0.596674046161557 0.15570987475652 PITA;miRanda -0.353208486746092 0.000363341591738215 NA NA NA hsa-miR-34a-5p CAPN6 1.9016323452565 1.43092834643601e-14 -3.47799832819863 8.37155036573641e-07 miRNATAP -0.829522644500449 5.55498523422973e-10 NA NA NA hsa-miR-140-5p CASD1 0.844753502512594 3.73722278438606e-05 -0.646018653497287 0.000104181902750095 miRNAWalker2_validate -0.109121745430043 0.00580138674161021 NA NA NA hsa-miR-140-5p CAST 0.844753502512594 3.73722278438606e-05 -0.656693837735563 0.000735435719229194 miRanda -0.220036930506198 1.501932955704e-06 NA NA NA hsa-miR-140-5p CBR4 0.844753502512594 3.73722278438606e-05 -0.139831965618233 0.458625233441578 miRanda -0.110838155630269 0.012779322826445 NA NA NA hsa-miR-140-5p CCDC146 0.844753502512594 3.73722278438606e-05 -0.734474900682893 0.00616016130488888 miRanda -0.193895545644554 0.00225763802639149 NA NA NA hsa-miR-34a-5p CCDC50 1.9016323452565 1.43092834643601e-14 -0.784992887432969 4.78414891397232e-08 miRNATAP -0.180304418748497 3.00267538143733e-11 NA NA NA hsa-miR-152-3p CCDC71 -0.0480232621705712 0.844347735441565 0.297490708956081 0.0289323400927195 MirTarget -0.176972120269068 2.30211219265506e-11 NA NA NA hsa-miR-194-5p CD302 1.8992998339217 3.76507853301977e-10 -1.6773932109923 3.38269892493687e-16 mirMAP -0.153312197270235 3.57771721155824e-06 NA NA NA hsa-miR-34a-5p CD44 1.9016323452565 1.43092834643601e-14 -0.796526651909205 0.0427559627960533 miRNAWalker2_validate;miRTarBase -0.275230949000913 0.000227008858457591 25572695;24423412;25551284;25044638;21240262;26231042;27497057;23314380 The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;Furthermore we identified CD44 as being targeted by miR-34a in MIBC cells following cisplatin treatment and increased CD44 expression could efficiently reverse the effect of miR-34a on MIBC cell proliferation colongenic potential and chemosensitivity; Cisplatin-based chemotherapy induced demethylation of miR-34a promoter and increased miR-34a expression which in turn sensitized MIBC cells to cisplatin and decreased the tumorigenicity and proliferation of cancer cells that by reducing the production of CD44;MicroRNA 34a functions as an anti metastatic microRNA and suppresses angiogenesis in bladder cancer by directly targeting CD44; In this study we focus on it that microRNA-34a functions as an anti-metastatic microRNA and suppress angiogenesis in bladder cancer by directly targeting CD44; Our study defines a major metastasis and angiogenesis suppressive role for mir-34a a microRNA functions as a tumor suppressor in bladder cancer by directly targeting CD44 which would be helpful as a therapeutic approach to block bladder cancer metastasis;Nanocomplex-assisted delivery of miR-34a induces cell apoptosis and suppresses migration proliferation and tumor growth of breast cancer cells via targeting CD44 and a Notch-1-signaling pathway;The microRNA miR 34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44; We identified and validated CD44 as a direct and functional target of miR-34a and found that CD44 knockdown phenocopied miR-34a overexpression in inhibiting prostate cancer regeneration and metastasis;Registered report: the microRNA miR 34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44; Tumors with exogenous miR-34a showed reduced levels of CD44 expression Figure 4A and mutation of two putative miR-34a binding sites in the CD33 3' UTR partially abrogated signal repression in a luciferase assay Figure 4D;Nanovesicle mediated systemic delivery of microRNA 34a for CD44 overexpressing gastric cancer stem cell therapy; MicroRNA-34a miR-34a is a promising candidate for CD44 repression-based cancer therapy as it has been reported to inhibit proliferation metastasis and survival of CD44-positive CSCs; Here we used nanovesicles containing PLI/miR complexes NVs/miR to systemically deliver miR-34a and induce miR-34a-triggered CD44 suppression in orthotopically and subcutaneously implanted tumors in nude mice;miR 34a inhibits the metastasis of osteosarcoma cells by repressing the expression of CD44; The ectopic overexpression of miR-34a significantly inhibited the migration and invasive ability of osteosarcoma cells by repressing the expression of CD44; These data suggest that miR-34a plays a tumor suppressor role in the metastasis of osteosarcoma cells by repressing the expression of CD44; Therefore it can be concluded that through the inhibition of CD44 expression levels miR-34a plays a significant role in the migration and invasion of osteosarcoma cells ;;metastasis;;metastasis;metastasis;metastasis;poor survival;metastasis bladder cancer;bladder cancer;bladder cancer;breast cancer;prostate cancer;prostate cancer;gastric cancer;sarcoma hsa-miR-34a-5p CD47 1.9016323452565 1.43092834643601e-14 -0.164318188512451 0.480797231316326 miRNATAP -0.203358997192752 3.63715466188499e-06 NA NA NA hsa-miR-194-5p CDC42BPA 1.8992998339217 3.76507853301977e-10 -1.41193338652648 2.19437213080473e-10 mirMAP -0.16909311626905 1.58922782248836e-06 NA NA NA hsa-miR-34a-5p CDC5L 1.9016323452565 1.43092834643601e-14 -0.0133441796456699 0.914544114469139 miRNAWalker2_validate -0.100913470803353 1.56476782258644e-05 NA NA NA hsa-miR-194-5p CDH2 1.8992998339217 3.76507853301977e-10 -0.373871027920648 0.510070676503065 miRNAWalker2_validate;miRTarBase;miRNATAP -0.649395196478716 5.02723808836733e-14 21845495;20979124 The results of real-time PCR and western blot highlighted that miR-194 interacted with N-cadherin and negatively regulated its expression at the translational level;The overexpression of miR-194 in liver mesenchymal-like cancer cells reduced the expression of the mesenchymal cell marker N-cadherin and suppressed invasion and migration of the mesenchymal-like cancer cells both in vitro and in vivo ; gastric cancer;liver cancer hsa-miR-140-5p CDH26 0.844753502512594 3.73722278438606e-05 0.91629847704858 0.147986141297379 miRanda -0.29632546982172 0.0483915552770217 NA NA NA hsa-miR-194-5p CDK14 1.8992998339217 3.76507853301977e-10 -0.626728056604694 0.0951702264506212 MirTarget -0.336337239063801 6.23695493430611e-09 NA NA NA hsa-miR-152-3p CDK19 -0.0480232621705712 0.844347735441565 -0.0781972308305914 0.561316574571832 MirTarget -0.103493515950243 9.69054000391412e-05 NA NA NA hsa-miR-34a-5p CDK6 1.9016323452565 1.43092834643601e-14 -0.774202349805119 0.064787030605636 miRNAWalker2_validate;miRTarBase;miRNATAP -0.519263514540718 3.07288169543583e-11 21702042;26104764 Molecular analyses identified Cdk6 and sirtuin SIRT-1 as being targeted by miR-34a in MI-TCC cells however inhibition of Cdk6 and SIRT-1 was not as effective as pre-miR-34a in mediating chemosensitization;The expression of microRNA 34a is inversely correlated with c MET and CDK6 and has a prognostic significance in lung adenocarcinoma patients; We found significant inverse correlations between miR-34a and c-MET R = -0.316 P = 0.028 and CDK6 expression R = -0.4582 P = 0.004 ; bladder cancer;lung cancer hsa-miR-140-5p CDK8 0.844753502512594 3.73722278438606e-05 -0.223244916290816 0.281918790397312 miRanda -0.148042871842442 0.00246784352869097 NA NA NA hsa-miR-140-5p CDKL5 0.844753502512594 3.73722278438606e-05 -0.879109020873068 0.0536713950931211 miRanda -0.25482835760482 0.0182590249726805 NA NA NA hsa-miR-34a-5p CDKN1C 1.9016323452565 1.43092834643601e-14 -1.44787932669971 3.93876960323515e-05 miRNATAP -0.28214470568661 2.69554466730922e-05 NA NA NA hsa-miR-34a-5p CDKN2C 1.9016323452565 1.43092834643601e-14 0.22688212352847 0.433133415352322 miRNAWalker2_validate -0.218709270480303 6.47001667111707e-05 NA NA NA hsa-miR-34a-5p CDON 1.9016323452565 1.43092834643601e-14 -2.61239140080419 3.20760880328893e-10 miRNAWalker2_validate -0.693223749816722 3.67879872744414e-19 NA NA NA hsa-miR-34a-5p CEBPB 1.9016323452565 1.43092834643601e-14 -0.382621335741301 0.125827051478291 miRNAWalker2_validate -0.105777754494497 0.0263195601731794 NA NA NA hsa-miR-34a-5p CELF2 1.9016323452565 1.43092834643601e-14 -3.04719737979328 4.72041352009215e-15 miRNATAP -0.628325647050444 1.66190482356385e-17 NA NA NA hsa-miR-194-5p CEP170 1.8992998339217 3.76507853301977e-10 -0.105046872769039 0.582677978132971 miRNATAP -0.15195602087961 2.57510239494493e-07 NA NA NA hsa-miR-34a-5p CEP170 1.9016323452565 1.43092834643601e-14 -0.105046872769039 0.582677978132971 miRNAWalker2_validate -0.249779327152147 1.69932832800405e-12 NA NA NA hsa-miR-140-5p CEP350 0.844753502512594 3.73722278438606e-05 -0.0396195524088032 0.770473605934005 MirTarget;miRanda -0.138313586295407 1.2931578673322e-05 NA NA NA hsa-miR-140-5p CHD6 0.844753502512594 3.73722278438606e-05 -0.223184963288209 0.239397816823554 miRanda -0.136081227678086 0.00233197057824256 NA NA NA hsa-miR-194-5p CHD9 1.8992998339217 3.76507853301977e-10 -0.801892369807601 9.04166624968584e-06 miRNATAP -0.132210426242059 2.8925917731603e-06 NA NA NA hsa-miR-140-5p CHIC1 0.844753502512594 3.73722278438606e-05 -1.02935210577655 6.82572270662798e-08 miRanda -0.201407599673136 9.212889108233e-06 NA NA NA hsa-miR-34a-5p CHM 1.9016323452565 1.43092834643601e-14 -0.349502164366627 0.0224735256043546 MirTarget -0.148031868106474 2.70948541597197e-07 NA NA NA hsa-miR-194-5p CIITA 1.8992998339217 3.76507853301977e-10 -0.0228897168841891 0.959678389546489 mirMAP -0.211359971585392 0.00279643353435424 NA NA NA hsa-miR-34a-5p CKAP5 1.9016323452565 1.43092834643601e-14 0.469620409267754 0.00244089758745052 miRNAWalker2_validate -0.113657621045968 0.000110533355229431 NA NA NA hsa-miR-194-5p CLIP4 1.8992998339217 3.76507853301977e-10 -1.61049215669349 1.71285040007646e-06 MirTarget -0.460729624566771 1.81882495841383e-19 NA NA NA hsa-miR-34a-5p CLOCK 1.9016323452565 1.43092834643601e-14 -0.505287121256611 0.0368861017220651 MirTarget -0.199150446873461 1.3679454059243e-05 NA NA NA hsa-miR-34a-5p CNST 1.9016323452565 1.43092834643601e-14 -0.933864860780951 8.53885783888989e-13 MirTarget -0.148435082691444 3.12923991420214e-09 NA NA NA hsa-miR-140-5p CNTN1 0.844753502512594 3.73722278438606e-05 -4.98280431564283 1.02293078354206e-09 PITA;miRanda -0.869860642775569 8.72725862675644e-06 NA NA NA hsa-miR-34a-5p CNTN2 1.9016323452565 1.43092834643601e-14 -3.83211666052187 2.86131751350646e-14 MirTarget;miRNATAP -0.541916829647253 2.97659039331274e-08 NA NA NA hsa-miR-34a-5p CNTNAP1 1.9016323452565 1.43092834643601e-14 -1.46743494896109 1.9231693722072e-07 MirTarget;miRNATAP -0.361612589518465 1.05688714782598e-11 NA NA NA hsa-miR-34a-5p CNTNAP2 1.9016323452565 1.43092834643601e-14 -1.31474968490572 0.115046978601333 miRNATAP -0.669498950447693 2.24310469946169e-05 NA NA NA hsa-miR-34a-5p COL12A1 1.9016323452565 1.43092834643601e-14 0.611588153376471 0.134337648747937 MirTarget;miRNATAP -0.279272089437204 0.00031460547783989 NA NA NA hsa-miR-34a-5p COL5A2 1.9016323452565 1.43092834643601e-14 0.192620068784939 0.640929497139689 MirTarget -0.411001400817508 1.17355783845956e-07 NA NA NA hsa-miR-34a-5p CORO1C 1.9016323452565 1.43092834643601e-14 -1.12142787999647 2.05016310243217e-07 MirTarget;miRNATAP -0.392545975185811 2.7908848641711e-23 NA NA NA hsa-miR-34a-5p CPEB2 1.9016323452565 1.43092834643601e-14 -1.81286293242937 3.69342740660752e-14 miRNATAP -0.291011235456475 2.84988574218449e-10 NA NA NA hsa-miR-34a-5p CPEB3 1.9016323452565 1.43092834643601e-14 -1.29730351097465 1.42439515101264e-11 miRNATAP -0.148597569036113 6.61814157178919e-05 NA NA NA hsa-miR-34a-5p CR2 1.9016323452565 1.43092834643601e-14 -1.531216649811 0.0724964985086472 MirTarget -0.786896680830366 1.00551297999258e-06 NA NA NA hsa-miR-34a-5p CREB5 1.9016323452565 1.43092834643601e-14 -2.27679484644664 4.56595042875634e-09 miRNATAP -0.504143048020364 7.47790714935664e-12 NA NA NA hsa-miR-34a-5p CRY2 1.9016323452565 1.43092834643601e-14 -1.68350116294318 3.19934219920631e-30 MirTarget -0.170427547249712 9.16183249254523e-09 NA NA NA hsa-miR-140-5p CRYAB 0.844753502512594 3.73722278438606e-05 -3.79700876239956 1.21656735068174e-15 miRanda -0.339303739029014 0.00351514812883945 NA NA NA hsa-miR-140-5p CRYBG3 0.844753502512594 3.73722278438606e-05 -1.11000638076797 4.51084274052305e-05 miRanda -0.131046599145528 0.0437031011733083 NA NA NA hsa-miR-140-5p CSDE1 0.844753502512594 3.73722278438606e-05 -0.719399067172928 2.28935205982748e-10 miRanda -0.176910819019862 3.37171220548129e-11 NA NA NA hsa-miR-34a-5p CSF1R 1.9016323452565 1.43092834643601e-14 -1.04722118455631 0.017969966085107 MirTarget;miRNATAP -0.461603981922354 2.97565476458688e-08 NA NA NA hsa-miR-34a-5p CTCFL 1.9016323452565 1.43092834643601e-14 0.387073671890494 0.137748809597237 MirTarget -0.12713116154714 0.0104269787056097 NA NA NA hsa-miR-34a-5p CTDSP2 1.9016323452565 1.43092834643601e-14 -0.394176502610892 0.00968619889118797 miRNATAP -0.220129999724653 4.60947226678767e-15 NA NA NA hsa-miR-140-5p CTNNA1 0.844753502512594 3.73722278438606e-05 -0.284632690198762 0.0151688080992981 miRanda -0.115600274788376 2.52848098385402e-05 NA NA NA hsa-miR-140-5p CTNNA3 0.844753502512594 3.73722278438606e-05 -1.93533463586447 0.000126947481038892 miRanda -0.247810161508247 0.0398083102714704 NA NA NA hsa-miR-140-5p CTSF 0.844753502512594 3.73722278438606e-05 -1.37788742533969 3.55827846399393e-07 miRanda -0.146046167845708 0.0245217793980251 NA NA NA hsa-miR-140-5p CUEDC1 0.844753502512594 3.73722278438606e-05 -1.00510262609884 2.08745251444007e-05 PITA;miRanda -0.20176892751298 0.000325270059073727 NA NA NA hsa-miR-34a-5p CXCL9 1.9016323452565 1.43092834643601e-14 1.49927890864915 0.0365261889675859 miRNAWalker2_validate -0.477505485788987 0.000460935899317861 NA NA NA hsa-miR-194-5p CYP26B1 1.8992998339217 3.76507853301977e-10 -0.687056430058883 0.15191405383577 mirMAP -0.338666057740629 5.41349815349712e-06 NA NA NA hsa-miR-140-5p CYP3A7 0.844753502512594 3.73722278438606e-05 0.593965802738344 0.343175248468117 miRanda -0.311110097767861 0.0360014362164645 NA NA NA hsa-miR-140-5p CYP4F12 0.844753502512594 3.73722278438606e-05 -1.42540722316972 0.0845331651354273 miRanda -0.614385757442848 0.00165421682042491 NA NA NA hsa-miR-194-5p CYTH3 1.8992998339217 3.76507853301977e-10 -0.272207622459217 0.193434635786576 mirMAP -0.238294735867286 6.42132059811524e-14 NA NA NA hsa-miR-34a-5p CYTH3 1.9016323452565 1.43092834643601e-14 -0.272207622459217 0.193434635786576 mirMAP -0.298341379420807 1.04053009788257e-14 NA NA NA hsa-miR-140-5p DAAM1 0.844753502512594 3.73722278438606e-05 -0.942213696830475 0.00027775597362759 miRanda -0.304699334450491 5.89677534024278e-07 NA NA NA hsa-miR-194-5p DAAM1 1.8992998339217 3.76507853301977e-10 -0.942213696830475 0.00027775597362759 miRNATAP -0.205815550659589 3.38369729014767e-07 NA NA NA hsa-miR-34a-5p DAAM1 1.9016323452565 1.43092834643601e-14 -0.942213696830475 0.00027775597362759 MirTarget;miRNATAP -0.314744989230111 9.66343935466443e-11 NA NA NA hsa-miR-140-5p DACT3 0.844753502512594 3.73722278438606e-05 -3.55228696797617 2.40562792379294e-15 miRanda -0.338475409598227 0.00204473151902853 NA NA NA hsa-miR-140-5p DAG1 0.844753502512594 3.73722278438606e-05 0.324338467436914 0.056984552677909 PITA;miRanda;miRNATAP -0.1238861650867 0.00204429063966812 NA NA NA hsa-miR-194-5p DCBLD2 1.8992998339217 3.76507853301977e-10 -0.127512036942836 0.735967995495379 MirTarget -0.303821450013933 1.98845046756714e-07 NA NA NA hsa-miR-34a-5p DDAH2 1.9016323452565 1.43092834643601e-14 -0.590477754227921 0.0158687108919737 miRNAWalker2_validate -0.150401571550365 0.00124243345827397 NA NA NA hsa-miR-140-5p DDHD2 0.844753502512594 3.73722278438606e-05 -0.56807721108283 0.00195245643616029 miRanda -0.150224228771595 0.00052929211816785 NA NA NA hsa-miR-34a-5p DDX21 1.9016323452565 1.43092834643601e-14 -0.174859915697837 0.500915985498721 miRNAWalker2_validate -0.178783649545985 0.000279363298038951 NA NA NA hsa-miR-34a-5p DDX24 1.9016323452565 1.43092834643601e-14 -0.701530380473533 7.79136794467797e-09 miRNAWalker2_validate -0.179493917005899 2.56802184701683e-15 NA NA NA hsa-miR-34a-5p DEGS1 1.9016323452565 1.43092834643601e-14 -0.464688481546998 0.0932815628732545 miRNAWalker2_validate -0.34245508039683 3.13311024092033e-11 NA NA NA hsa-miR-152-3p DENND4C -0.0480232621705712 0.844347735441565 -0.643803873398549 0.00048993151445191 MirTarget -0.115057559259006 0.00181023407673078 NA NA NA hsa-miR-140-5p DGKB 0.844753502512594 3.73722278438606e-05 -4.23893797514834 6.0048129781079e-13 miRanda -0.514335265029826 0.000318402067871678 NA NA NA hsa-miR-140-5p DIP2C 0.844753502512594 3.73722278438606e-05 -1.11454994396843 8.17191528862197e-07 miRanda -0.188970599312239 0.000457808996896803 NA NA NA hsa-miR-194-5p DIP2C 1.8992998339217 3.76507853301977e-10 -1.11454994396843 8.17191528862197e-07 miRNATAP -0.118691315199546 0.000889768356425165 NA NA NA hsa-miR-34a-5p DIRAS1 1.9016323452565 1.43092834643601e-14 -3.18575368653498 5.11429118270038e-08 mirMAP -0.654174247818005 4.28381101103868e-09 NA NA NA hsa-miR-140-5p DIXDC1 0.844753502512594 3.73722278438606e-05 -3.01066558370526 1.36952954348107e-19 miRanda -0.281229607226912 0.000616114973089476 NA NA NA hsa-miR-34a-5p DIXDC1 1.9016323452565 1.43092834643601e-14 -3.01066558370526 1.36952954348107e-19 MirTarget -0.723463516687314 5.53009644256615e-32 NA NA NA hsa-miR-140-5p DLG2 0.844753502512594 3.73722278438606e-05 -3.79723748090986 3.01897311382045e-14 PITA;miRanda;miRNATAP -0.462730698803255 0.000141436959262584 NA NA NA hsa-miR-34a-5p DLL1 1.9016323452565 1.43092834643601e-14 -0.904670506944925 0.0103219273832339 miRNAWalker2_validate;miRTarBase;miRNATAP -0.163044794044794 0.0155179086068895 22438124 Delta tocotrienol suppresses Notch 1 pathway by upregulating miR 34a in nonsmall cell lung cancer cells lung squamous cell cancer hsa-miR-194-5p DMD 1.8992998339217 3.76507853301977e-10 -3.69368719337714 3.87883942927561e-15 MirTarget;miRNATAP -0.515495005339277 4.16919120832257e-12 NA NA NA hsa-miR-152-3p DMPK -0.0480232621705712 0.844347735441565 -1.53311728236998 5.18442338045932e-14 MirTarget -0.172438218426917 3.37305188050884e-05 NA NA NA hsa-miR-140-5p DNAH7 0.844753502512594 3.73722278438606e-05 -0.487310780013068 0.138611198531795 miRanda -0.224399681208614 0.00389604301487039 NA NA NA hsa-miR-140-5p DNAJA4 0.844753502512594 3.73722278438606e-05 0.202450776661609 0.440060058169905 miRanda -0.190788826037564 0.00202731089585728 NA NA NA hsa-miR-140-5p DNAJC18 0.844753502512594 3.73722278438606e-05 -1.28115430590081 1.89417828596086e-11 miRanda -0.118625317959022 0.0102502827190704 NA NA NA hsa-miR-140-5p DNAJC27 0.844753502512594 3.73722278438606e-05 -0.903335645338092 1.56099354646174e-09 miRanda -0.141675600650937 7.57766305503251e-05 NA NA NA hsa-miR-140-5p DNMBP 0.844753502512594 3.73722278438606e-05 -0.895665764961143 0.000122566302604292 miRanda -0.1661002592223 0.00273419295023784 NA NA NA hsa-miR-152-3p DOCK6 -0.0480232621705712 0.844347735441565 0.294783499602813 0.0569995219217505 MirTarget -0.14348600366059 2.57941509195419e-06 NA NA NA hsa-miR-140-5p DOK6 0.844753502512594 3.73722278438606e-05 -3.80154682978045 3.47096997618837e-18 mirMAP -0.342472110987343 0.0014781699628837 NA NA NA hsa-miR-34a-5p DPYSL4 1.9016323452565 1.43092834643601e-14 -1.62416184385166 0.0138700586678457 miRNATAP -0.404329081013691 0.00130520806060972 NA NA NA hsa-miR-140-5p DST 0.844753502512594 3.73722278438606e-05 -1.11542714896545 9.14769438027749e-05 mirMAP -0.203045598802249 0.00276354246728312 NA NA NA hsa-miR-140-5p DTNA 0.844753502512594 3.73722278438606e-05 -4.06049121456747 1.59577306327407e-12 PITA;miRanda -0.466662105644951 0.000818919097942881 NA NA NA hsa-miR-140-5p DUOX2 0.844753502512594 3.73722278438606e-05 -0.88411309341632 0.192400298866423 miRanda;miRNATAP -0.353280285000575 0.0278582161509108 NA NA NA hsa-miR-194-5p DUSP10 1.8992998339217 3.76507853301977e-10 0.000920025183515083 0.997792983773082 miRNATAP -0.156284967722718 0.00261176652743425 NA NA NA hsa-miR-34a-5p DUSP8 1.9016323452565 1.43092834643601e-14 -2.17002902781112 4.33786956113647e-11 MirTarget -0.349194381507623 3.49403240680451e-08 NA NA NA hsa-miR-152-3p ECHS1 -0.0480232621705712 0.844347735441565 0.416079263761056 0.00970432848365101 miRNAWalker2_validate -0.138009799151077 1.4513876721986e-05 NA NA NA hsa-miR-140-5p EDA 0.844753502512594 3.73722278438606e-05 -1.83319387087113 2.58541711347109e-05 miRanda -0.356161971681047 0.000594697162691124 NA NA NA hsa-miR-140-5p EFCAB2 0.844753502512594 3.73722278438606e-05 -0.42821626478122 0.061897492265423 miRanda -0.125367899869456 0.0209060813175596 NA NA NA hsa-miR-140-5p EFHC2 0.844753502512594 3.73722278438606e-05 -2.72749810319719 2.40160283304019e-07 miRanda -0.327259262219185 0.00982868683788687 NA NA NA hsa-miR-140-5p EGFR 0.844753502512594 3.73722278438606e-05 -0.229170429190265 0.593897211976523 miRanda -0.290336016621899 0.00422174515988415 NA NA NA hsa-miR-140-5p EGLN3 0.844753502512594 3.73722278438606e-05 -0.285863716152797 0.490295181244631 miRanda -0.395489547347986 4.86832884416747e-05 NA NA NA hsa-miR-194-5p EGR2 1.8992998339217 3.76507853301977e-10 -2.81415398238775 4.48213127682575e-11 miRNATAP -0.460242767715335 6.04255339606759e-12 NA NA NA hsa-miR-194-5p EHBP1 1.8992998339217 3.76507853301977e-10 -0.731967713468599 6.58011702726464e-05 MirTarget;miRNATAP -0.22578142191167 6.01561488719157e-16 NA NA NA hsa-miR-152-3p ELF5 -0.0480232621705712 0.844347735441565 0.598658693294086 0.42287192357736 MirTarget -0.557827747338754 0.000166202394378572 NA NA NA hsa-miR-194-5p EMCN 1.8992998339217 3.76507853301977e-10 -2.36142860391053 2.65167966874759e-13 MirTarget -0.114538163041392 0.0280679918175988 NA NA NA hsa-miR-34a-5p EMP1 1.9016323452565 1.43092834643601e-14 -2.56201861439692 2.636649671729e-13 miRNAWalker2_validate -0.262080004827708 0.000128173715780061 NA NA NA hsa-miR-194-5p ENAH 1.8992998339217 3.76507853301977e-10 -0.681669392071856 0.000630502361017488 mirMAP;miRNATAP -0.166603452182168 7.22711685151461e-08 NA NA NA hsa-miR-140-5p ENPP5 0.844753502512594 3.73722278438606e-05 -1.20404032228796 0.0200435406925418 miRanda -0.397521743336654 0.00116971836819751 NA NA NA hsa-miR-140-5p EP300 0.844753502512594 3.73722278438606e-05 -0.259813561364416 0.130645976324069 miRNAWalker2_validate -0.116180580124631 0.0041461159891489 NA NA NA hsa-miR-152-3p EPB41L1 -0.0480232621705712 0.844347735441565 -0.408139612273053 0.152365993125717 MirTarget -0.284662707714622 4.01772402133592e-07 NA NA NA hsa-miR-34a-5p EPB41L2 1.9016323452565 1.43092834643601e-14 -1.52525304500616 1.08185687005731e-08 miRNAWalker2_validate -0.419310580386464 3.6963933562603e-17 NA NA NA hsa-miR-140-5p EPC2 0.844753502512594 3.73722278438606e-05 -0.519244150309446 9.26294390163578e-05 miRanda -0.168219909315669 6.38744920158102e-08 NA NA NA hsa-miR-194-5p EPHA3 1.8992998339217 3.76507853301977e-10 -3.17995997634921 4.72542752542387e-15 miRNATAP -0.403597057506416 4.02350645232695e-10 NA NA NA hsa-miR-140-5p EPHA6 0.844753502512594 3.73722278438606e-05 -3.7617134527257 2.58130561254474e-12 miRanda -0.454372190945846 0.000487364532394992 NA NA NA hsa-miR-140-5p EPN2 0.844753502512594 3.73722278438606e-05 -0.459255395826149 0.00302308268590588 miRanda -0.179787585643579 7.20852478558191e-07 NA NA NA hsa-miR-34a-5p ERC1 1.9016323452565 1.43092834643601e-14 -1.0981015647741 3.01720605629387e-09 mirMAP;miRNATAP -0.350825679987726 3.55360868118575e-25 NA NA NA hsa-miR-194-5p ERG 1.8992998339217 3.76507853301977e-10 -1.3479378771967 2.23511589174121e-07 MirTarget -0.202502371103508 7.29540949047768e-07 NA NA NA hsa-miR-152-3p ESRRG -0.0480232621705712 0.844347735441565 -2.25607825417513 0.000204861853606297 MirTarget -0.688652793334949 9.82298635465307e-09 NA NA NA hsa-miR-34a-5p ESYT2 1.9016323452565 1.43092834643601e-14 -0.746139987963661 9.56205989329786e-07 miRNAWalker2_validate -0.151148519995629 1.73556812772753e-07 NA NA NA hsa-miR-34a-5p EVC 1.9016323452565 1.43092834643601e-14 -1.68202719143955 3.16757001123632e-05 mirMAP -0.41704137787758 5.2678666002636e-08 NA NA NA hsa-miR-194-5p EXOC5 1.8992998339217 3.76507853301977e-10 -0.347825206882579 0.00996981836282781 MirTarget;miRNATAP -0.109809307729957 1.36267081125856e-07 NA NA NA hsa-miR-194-5p EYA4 1.8992998339217 3.76507853301977e-10 -2.8072879672292 6.54973849377546e-08 miRNATAP -0.485415752451984 2.32606585437776e-09 NA NA NA hsa-miR-34a-5p F2RL2 1.9016323452565 1.43092834643601e-14 -0.074170778593706 0.882857232515843 MirTarget;miRNATAP -0.364915734765217 0.000128912113283974 NA NA NA hsa-miR-34a-5p FAIM2 1.9016323452565 1.43092834643601e-14 -5.19306317048563 1.8116701555082e-19 mirMAP -0.83047667568324 9.76727475500724e-14 NA NA NA hsa-miR-140-5p FAM131A 0.844753502512594 3.73722278438606e-05 -0.838029286740817 0.000197950764595924 miRanda -0.115696684316934 0.0309997948024728 NA NA NA hsa-miR-34a-5p FAM131B 1.9016323452565 1.43092834643601e-14 -1.33611947709599 0.000824414564419036 MirTarget -0.456748498365561 1.21255636147528e-09 NA NA NA hsa-miR-152-3p FAM149A -0.0480232621705712 0.844347735441565 -3.04998940343685 8.38389814640257e-09 MirTarget -0.286238886951889 0.00772905042446029 NA NA NA hsa-miR-34a-5p FAM168A 1.9016323452565 1.43092834643601e-14 -0.715878355157019 0.0048087062534339 mirMAP -0.360026152917752 1.92370403342131e-14 NA NA NA hsa-miR-140-5p FAM172A 0.844753502512594 3.73722278438606e-05 -1.02736268216003 8.57610493622667e-11 miRanda -0.176347917783218 3.24470556086399e-06 NA NA NA hsa-miR-140-5p FAM179B 0.844753502512594 3.73722278438606e-05 -0.424100682033217 0.00497090185645427 miRanda -0.134562311781583 0.000154018489558529 NA NA NA hsa-miR-140-5p FAM189A1 0.844753502512594 3.73722278438606e-05 -1.9588737664665 0.00881316385909795 miRanda -0.417593981920932 0.0187061416203232 NA NA NA hsa-miR-194-5p FAM19A5 1.8992998339217 3.76507853301977e-10 -0.926434583791826 0.0378356582381318 miRNATAP -0.320816740004513 3.71051444944824e-06 NA NA NA hsa-miR-194-5p FAM46A 1.8992998339217 3.76507853301977e-10 -1.53838927503324 2.52497889501001e-11 miRNATAP -0.10870186978272 0.0032393805420194 NA NA NA hsa-miR-34a-5p FAM46A 1.9016323452565 1.43092834643601e-14 -1.53838927503324 2.52497889501001e-11 miRNAWalker2_validate;miRNATAP -0.148703953998686 0.000915283294094036 NA NA NA hsa-miR-140-5p FAM66D 0.844753502512594 3.73722278438606e-05 -1.39850694643829 0.0315585253644388 miRanda -0.244312133097493 0.0446732785175442 NA NA NA hsa-miR-34a-5p FAM78A 1.9016323452565 1.43092834643601e-14 -0.17566660865732 0.571673572062009 mirMAP -0.163128244620608 0.00572066900207895 NA NA NA hsa-miR-140-5p FAT1 0.844753502512594 3.73722278438606e-05 0.120722960714863 0.674434982080052 miRanda -0.16080127823798 0.0178932181001106 NA NA NA hsa-miR-34a-5p FAT3 1.9016323452565 1.43092834643601e-14 -2.79096679677476 3.40343867448209e-06 miRNATAP -0.238159689235018 0.0399842431144992 NA NA NA hsa-miR-34a-5p FAT4 1.9016323452565 1.43092834643601e-14 -2.56665423966553 1.33682061275506e-12 MirTarget -0.550641148269351 9.44525623155378e-16 NA NA NA hsa-miR-140-5p FCHO2 0.844753502512594 3.73722278438606e-05 -0.438286274224125 0.00271373684474576 PITA;miRanda -0.105239575817944 0.00231155089697872 NA NA NA hsa-miR-34a-5p FGD6 1.9016323452565 1.43092834643601e-14 0.159851453122091 0.537015582004778 MirTarget;miRNATAP -0.277924902556364 9.82127532053168e-09 NA NA NA hsa-miR-140-5p FHIT 0.844753502512594 3.73722278438606e-05 -0.651649067614083 0.116560961884213 miRanda -0.245904062405421 0.0123381992392095 NA NA NA hsa-miR-34a-5p FIGN 1.9016323452565 1.43092834643601e-14 -0.337235559801681 0.468810304921439 miRNAWalker2_validate -0.281475875337614 0.00145298251694832 NA NA NA hsa-miR-194-5p FLI1 1.8992998339217 3.76507853301977e-10 -1.10881984531465 6.56713737767845e-05 MirTarget -0.265858481979461 6.38997217598977e-10 NA NA NA hsa-miR-152-3p FLOT2 -0.0480232621705712 0.844347735441565 0.210199274690725 0.203605970305864 MirTarget -0.194558294217847 1.67596086915349e-09 NA NA NA hsa-miR-34a-5p FMNL2 1.9016323452565 1.43092834643601e-14 -0.529083916997439 0.0893498623305676 miRNATAP -0.463303191057109 6.30936473695651e-16 26103003 MicroRNA 34a targets FMNL2 and E2F5 and suppresses the progression of colorectal cancer; FMNL2 and E2F5 were identified as direct targets of miR-34a; Reintroduction of FMNL2 or E2F5 without 3'UTR region reversed the inhibitory effects of miR-34a on cell proliferation and invasion; MiR-34a was down-regulated in CRC cells and inversely correlated with FMNL2 and E2F5 expressions; Our study suggests that miR-34a is an important tumor suppressor of CRC progression by targeting FMNL2 and E2F5 thus providing new insight into the molecular mechanisms underlying CRC progression and establishing a strong potential for the application of miR-34a as a novel therapeutic marker against CRC progression colorectal cancer hsa-miR-140-5p FNDC5 0.844753502512594 3.73722278438606e-05 -1.42240888322157 0.000164740785085554 PITA;miRanda -0.20810924325693 0.0207678611518624 NA NA NA hsa-miR-34a-5p FOXJ2 1.9016323452565 1.43092834643601e-14 -0.61900156905543 0.000173363046232332 MirTarget;miRNATAP -0.166339600987044 9.1041064614196e-08 NA NA NA hsa-miR-34a-5p FOXK1 1.9016323452565 1.43092834643601e-14 -0.292133622173698 0.132125670821422 mirMAP -0.133228968661877 0.000287915852148464 NA NA NA hsa-miR-34a-5p FOXN2 1.9016323452565 1.43092834643601e-14 -0.201449704983224 0.266609612236866 miRNATAP -0.113970816965055 0.000908187641903563 NA NA NA hsa-miR-140-5p FOXN3 0.844753502512594 3.73722278438606e-05 -1.43525991184281 2.70084540955391e-16 MirTarget;PITA -0.230750302056374 5.27256126350869e-08 NA NA NA hsa-miR-34a-5p FOXN3 1.9016323452565 1.43092834643601e-14 -1.43525991184281 2.70084540955391e-16 miRNATAP -0.289797930927111 2.75546105297621e-18 NA NA NA hsa-miR-194-5p FOXO1 1.8992998339217 3.76507853301977e-10 -1.06087355985292 3.97103810866528e-08 miRNATAP -0.177639380414051 3.99206480400442e-09 24631529 Gα12gep oncogene inhibits FOXO1 in hepatocellular carcinoma as a consequence of miR 135b and miR 194 dysregulation; In addition Gα12QL repressed miR-194 cluster gene products 194/192/215 which contributed to MDM2-mediated FOXO1 repression; Moreover decrease of FOXO1 or miR-194 was statistically significant between stages T1 and T2 whereas increase of miR-135b discriminated tumor stage T3a versus T1/T2 staging liver cancer hsa-miR-140-5p FOXP1 0.844753502512594 3.73722278438606e-05 -0.873044719534777 1.61392354745552e-06 miRanda -0.135034345140903 0.00187087232838508 NA NA NA hsa-miR-140-5p FOXP2 0.844753502512594 3.73722278438606e-05 -3.99353205302265 7.58170962329672e-11 MirTarget;PITA;miRanda;miRNATAP -0.542439857890245 0.000248560436620481 NA NA NA hsa-miR-194-5p FOXP2 1.8992998339217 3.76507853301977e-10 -3.99353205302265 7.58170962329672e-11 miRNATAP -0.644413670792647 2.1005654034383e-11 NA NA NA hsa-miR-140-5p FRMD6 0.844753502512594 3.73722278438606e-05 -0.932146068496432 0.00182819765018773 miRanda -0.339567329119055 1.38173957537487e-06 NA NA NA hsa-miR-34a-5p FUT8 1.9016323452565 1.43092834643601e-14 -0.00759422508200558 0.971820058391575 miRNATAP -0.103025346753863 0.0116497865889195 27533464 Furthermore using microRNA array we identified FUT8 as one of the miR-26a miR-34a and miR-146a-targeted genes liver cancer hsa-miR-140-5p FYCO1 0.844753502512594 3.73722278438606e-05 -1.6226100593392 1.01871130782658e-16 MirTarget;miRanda -0.380241731095461 2.20468352633166e-16 NA NA NA hsa-miR-140-5p FZD3 0.844753502512594 3.73722278438606e-05 -0.309421802986829 0.225620520315636 miRanda -0.188169794963344 0.00178065542348547 NA NA NA hsa-miR-140-5p FZD6 0.844753502512594 3.73722278438606e-05 0.392854306882718 0.0923152139379722 MirTarget;miRanda -0.137728919670016 0.0125680010765223 NA NA NA hsa-miR-34a-5p GAB1 1.9016323452565 1.43092834643601e-14 -0.893753640154927 1.35889350853124e-06 MirTarget -0.188182529050272 8.58822853873461e-08 NA NA NA hsa-miR-34a-5p GAS1 1.9016323452565 1.43092834643601e-14 -2.1882386842391 0.000375177981793486 miRNAWalker2_validate;miRNATAP -0.926566103710993 4.11296403810168e-16 24220341 MiR 34a targets GAS1 to promote cell proliferation and inhibit apoptosis in papillary thyroid carcinoma via PI3K/Akt/Bad pathway; Both miR-34a and GAS1 are frequently down-regulated in various tumors; However it has been reported that while GAS1 is down-regulated in papillary thyroid carcinoma PTC miR-34a is up-regulated in this specific type of cancer although their potential roles in PTC tumorigenesis have not been examined to date; A computational search revealed that miR-34a putatively binds to the 3'-UTR of GAS1 gene; In the present study we confirmed previous findings that miR-34a is up-regulated and GAS1 down-regulated in PTC tissues; Further studies indicated that GAS1 is directly targeted by miR-34a; Silencing of GAS1 had similar growth-promoting effects as overexpression of miR-34a; Taken together our results demonstrate that miR-34a regulates GAS1 expression to promote proliferation and suppress apoptosis in PTC cells via PI3K/Akt/Bad pathway tumorigenesis thyroid cancer hsa-miR-194-5p GAS7 1.8992998339217 3.76507853301977e-10 -2.67478964713793 6.70176551418169e-10 mirMAP -0.584322106321728 1.52973023188451e-18 NA NA NA hsa-miR-140-5p GBF1 0.844753502512594 3.73722278438606e-05 -0.130356229468309 0.207464356080574 PITA;miRanda -0.100500603076412 3.06665411971276e-05 NA NA NA hsa-miR-34a-5p GBP5 1.9016323452565 1.43092834643601e-14 0.912417033493665 0.155449791355904 MirTarget -0.382499169463647 0.0017369345763329 NA NA NA hsa-miR-140-5p GCOM1 0.844753502512594 3.73722278438606e-05 -2.6633093550746 6.29621915337476e-10 miRanda -0.673458297204778 3.77370224446338e-11 NA NA NA hsa-miR-34a-5p GDPD5 1.9016323452565 1.43092834643601e-14 -0.630310111922114 0.0293909740910197 mirMAP -0.213268425366357 0.000102263075725957 NA NA NA hsa-miR-34a-5p GEMIN5 1.9016323452565 1.43092834643601e-14 -0.199708326167447 0.120238384750959 miRNAWalker2_validate -0.118367196443607 9.17420434212037e-07 NA NA NA hsa-miR-34a-5p GFRA1 1.9016323452565 1.43092834643601e-14 -4.99535302188274 6.14065741522982e-16 miRNATAP -0.468603795786328 0.000115075184080931 NA NA NA hsa-miR-34a-5p GLCE 1.9016323452565 1.43092834643601e-14 0.259402696052151 0.172049271225319 MirTarget;miRNATAP -0.103424672425006 0.00413607836566836 NA NA NA hsa-miR-140-5p GLI3 0.844753502512594 3.73722278438606e-05 -0.852256004040062 0.0202428205589312 PITA;miRanda -0.252559233814851 0.00365578645950619 NA NA NA hsa-miR-34a-5p GLIS2 1.9016323452565 1.43092834643601e-14 -0.610818722003668 0.0527901481345749 MirTarget -0.40401113067284 5.8023012566225e-12 NA NA NA hsa-miR-194-5p GLIS3 1.8992998339217 3.76507853301977e-10 -0.78878644266897 0.0245942929492481 miRNATAP -0.216609600491275 7.57542769150163e-05 NA NA NA hsa-miR-140-5p GLS2 0.844753502512594 3.73722278438606e-05 0.39169116877749 0.367867444803309 miRanda -0.267290941543728 0.00933296849155617 NA NA NA hsa-miR-140-5p GLUL 0.844753502512594 3.73722278438606e-05 -0.784173404532954 0.000315027134440472 miRanda -0.104277759692455 0.0442383562818598 NA NA NA hsa-miR-34a-5p GNAO1 1.9016323452565 1.43092834643601e-14 -3.60402838064813 1.60858876204295e-14 mirMAP -0.912829449298286 9.94616074995399e-26 NA NA NA hsa-miR-140-5p GNG12 0.844753502512594 3.73722278438606e-05 -1.00694431810149 1.61985728260734e-06 PITA;miRanda -0.215923167393918 1.48186394256009e-05 NA NA NA hsa-miR-34a-5p GPC6 1.9016323452565 1.43092834643601e-14 -2.70666453497929 7.48358520640858e-07 MirTarget -0.7555559007653 1.85995303111966e-13 NA NA NA hsa-miR-140-5p GPD1L 0.844753502512594 3.73722278438606e-05 -1.18117958887406 0.000269533833941388 miRanda -0.157202028913676 0.0419800927815479 NA NA NA hsa-miR-140-5p GPHN 0.844753502512594 3.73722278438606e-05 -0.449173569739282 0.0361923352520887 miRanda -0.207391039000609 3.89348315545558e-05 NA NA NA hsa-miR-194-5p GPM6B 1.8992998339217 3.76507853301977e-10 -2.38616048413304 8.19968989398376e-13 miRNATAP -0.381371617532915 2.90475726893577e-13 NA NA NA hsa-miR-140-5p GPR135 0.844753502512594 3.73722278438606e-05 -1.47827399309032 3.47912182868266e-07 miRanda -0.221164246113905 0.00144280927293094 NA NA NA hsa-miR-34a-5p GPR156 1.9016323452565 1.43092834643601e-14 -1.25653479411111 0.0136152326151988 MirTarget -0.83298074486789 3.88570187308379e-19 NA NA NA hsa-miR-34a-5p GREM2 1.9016323452565 1.43092834643601e-14 -4.9852150121131 1.5808751237327e-14 MirTarget;miRNATAP -0.444714182367586 0.00048212236936567 NA NA NA hsa-miR-140-5p GRIA3 0.844753502512594 3.73722278438606e-05 -2.06852702129128 7.47403992493886e-05 miRanda -0.320204096794265 0.010153913326141 NA NA NA hsa-miR-34a-5p GRID1 1.9016323452565 1.43092834643601e-14 -0.61772636758298 0.168665600534068 miRNATAP -0.177009786008275 0.0386174462416638 NA NA NA hsa-miR-140-5p GTF2A1 0.844753502512594 3.73722278438606e-05 -0.43839369936176 0.177762306654447 MirTarget -0.209263509916946 0.00648953821355789 NA NA NA hsa-miR-140-5p GTF2IRD2 0.844753502512594 3.73722278438606e-05 -0.914228465752624 3.74427577839405e-06 miRanda -0.187190659586661 6.70260826502253e-05 NA NA NA hsa-miR-140-5p GTF2IRD2B 0.844753502512594 3.73722278438606e-05 -1.33550770165176 4.45307360684208e-07 miRanda -0.277064804544969 1.06652140596724e-05 NA NA NA hsa-miR-140-5p GTF2IRD2P1 0.844753502512594 3.73722278438606e-05 -1.2662041394094 3.85607604646204e-07 miRanda -0.219041684290082 0.00023429607451537 NA NA NA hsa-miR-34a-5p GYG1 1.9016323452565 1.43092834643601e-14 -0.707345868023464 1.26958679121177e-07 miRNAWalker2_validate -0.136487387233102 8.11420430054654e-08 NA NA NA hsa-miR-140-5p HAND2 0.844753502512594 3.73722278438606e-05 -4.38574004909209 2.52155565733168e-14 PITA;miRanda;miRNATAP -0.51346097223962 0.000248231273292872 NA NA NA hsa-miR-34a-5p HAPLN4 1.9016323452565 1.43092834643601e-14 0.126147088785814 0.776209220485584 mirMAP -0.206852231928114 0.014314520193702 NA NA NA hsa-miR-194-5p HBEGF 1.8992998339217 3.76507853301977e-10 -2.25664314425713 3.15709120593558e-11 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.241862770494101 7.79755450764721e-06 NA NA NA hsa-miR-140-5p HDAC4 0.844753502512594 3.73722278438606e-05 -1.80036091395253 1.96398022917234e-18 miRNAWalker2_validate;miRTarBase;PITA;miRanda;miRNATAP -0.145632549057136 0.00404122664267405 19734943 Histone deacetylase 4 HDAC4 was confirmed to be one of the important targets of miR-140; Taken together our findings indicate that miR-140 is involved in the chemoresistance by reduced cell proliferation through G1 and G2 phase arrest mediated in part through the suppression of HDAC4 miR-140 may be a candidate target to develop novel therapeutic strategy to overcome drug resistance drug resistance sarcoma hsa-miR-140-5p HECTD2 0.844753502512594 3.73722278438606e-05 -1.25606087758468 2.15810687487391e-09 PITA;miRanda -0.162916767733458 0.00124054571199174 NA NA NA hsa-miR-34a-5p HIPK2 1.9016323452565 1.43092834643601e-14 -0.569766486297519 0.0176403507362252 mirMAP -0.219334183339887 1.30387235923701e-06 NA NA NA hsa-miR-34a-5p HMGA2 1.9016323452565 1.43092834643601e-14 3.20669547753427 0.000374823650222635 miRNAWalker2_validate -0.570917515229347 0.000926842607230156 18803879 miR-34 targets Notch HMGA2 and Bcl-2 genes involved in the self-renewal and survival of cancer stem cells; Human gastric cancer Kato III cells with miR-34 restoration reduced the expression of target genes Bcl-2 Notch and HMGA2; The mechanism of miR-34-mediated suppression of self-renewal appears to be related to the direct modulation of downstream targets Bcl-2 Notch and HMGA2 indicating that miR-34 may be involved in gastric cancer stem cell self-renewal/differentiation decision-making poor survival;differentiation gastric cancer hsa-miR-140-5p HMGN5 0.844753502512594 3.73722278438606e-05 -1.07677466387703 0.00138921911687781 miRanda -0.270695555600342 0.000694478957083149 NA NA NA hsa-miR-34a-5p HPSE 1.9016323452565 1.43092834643601e-14 0.666621208462529 0.156142725087854 MirTarget -0.422120081290521 1.9400254393159e-06 NA NA NA hsa-miR-194-5p HS3ST2 1.8992998339217 3.76507853301977e-10 -0.459854923580174 0.354231549724622 MirTarget;miRNATAP -0.271363892249887 0.000455823077028667 NA NA NA hsa-miR-152-3p HS6ST2 -0.0480232621705712 0.844347735441565 0.879829199954371 0.159632886755658 miRNAWalker2_validate -0.301937197866455 0.0155293361558367 NA NA NA hsa-miR-140-5p HSPA4L 0.844753502512594 3.73722278438606e-05 -1.28853180846731 0.00635358533332265 PITA;miRanda -0.259849197070346 0.0205025218021751 NA NA NA hsa-miR-140-5p ICK 0.844753502512594 3.73722278438606e-05 -0.464668835703463 0.00460085087680801 miRanda -0.153847888565289 6.74871844764709e-05 NA NA NA hsa-miR-140-5p IDS 0.844753502512594 3.73722278438606e-05 -0.672907485024052 2.54226491745287e-05 miRanda -0.142112377306036 0.000175166724999966 NA NA NA hsa-miR-140-5p IGF1R 0.844753502512594 3.73722278438606e-05 -0.486024248749606 0.0460954581792042 PITA;miRNATAP -0.210132849945263 0.000252820917193275 24039995 Integrated analysis identified IGF1R as a direct and functional target of miR-140; Knockdown of IGF1R inhibited cell proliferation and invasion resembling that of miR-140 overexpression while overexpression of IGF1R attenuated the function of miR-140 in NSCLC cells; Together our results highlight the significance of miR-140 and IGF1R in the development and progression of NSCLC progression lung squamous cell cancer hsa-miR-194-5p IGF1R 1.8992998339217 3.76507853301977e-10 -0.486024248749606 0.0460954581792042 miRNAWalker2_validate;miRTarBase;miRNATAP -0.188748374877298 5.71579919612031e-07 NA NA NA hsa-miR-34a-5p IGF2BP3 1.9016323452565 1.43092834643601e-14 2.6299525966699 0.000210097359173809 miRNAWalker2_validate -0.356009987313672 0.00889898177532554 NA NA NA hsa-miR-34a-5p IGFBP5 1.9016323452565 1.43092834643601e-14 -2.81356106012445 2.49904604393601e-08 mirMAP -0.664249410135242 3.4074345255981e-12 NA NA NA hsa-miR-140-5p IL20RA 0.844753502512594 3.73722278438606e-05 0.713677535753439 0.0930777368240817 miRanda -0.231642453267605 0.0213725645229318 NA NA NA hsa-miR-34a-5p IL6R 1.9016323452565 1.43092834643601e-14 -1.86576803083567 2.67166891084766e-06 MirTarget -0.286520476038065 0.000171312695111806 NA NA NA hsa-miR-34a-5p INHBB 1.9016323452565 1.43092834643601e-14 -1.63532338824153 1.3666012569742e-06 miRNATAP -0.243244739481652 0.000182207922114652 NA NA NA hsa-miR-140-5p INMT 0.844753502512594 3.73722278438606e-05 -2.75656433756649 3.38189882457643e-13 miRanda -0.183795341722379 0.0467759993154379 NA NA NA hsa-miR-140-5p IQCH 0.844753502512594 3.73722278438606e-05 0.295412584432407 0.178058026469258 miRanda -0.149582137663806 0.00385295930566538 NA NA NA hsa-miR-140-5p IRAK1BP1 0.844753502512594 3.73722278438606e-05 -0.293550425952769 0.152485196734746 miRanda -0.123643767123376 0.0107244407649318 NA NA NA hsa-miR-140-5p ITGA1 0.844753502512594 3.73722278438606e-05 -1.43194652766846 3.62878143052896e-06 miRanda -0.171525094262808 0.0204550499904173 NA NA NA hsa-miR-194-5p ITGA9 1.8992998339217 3.76507853301977e-10 -2.58466582885052 1.23539072812213e-10 miRNAWalker2_validate;miRTarBase -0.239239673825585 0.000188503663699313 NA NA NA hsa-miR-140-5p ITIH5 0.844753502512594 3.73722278438606e-05 -4.03070581900993 1.65867703146852e-22 miRanda -0.336335752666222 0.001076179985283 NA NA NA hsa-miR-194-5p ITPKB 1.8992998339217 3.76507853301977e-10 -1.70322432049595 4.43562078746451e-23 MirTarget;miRNATAP -0.155994970865862 2.59428275037971e-08 NA NA NA hsa-miR-34a-5p ITPKB 1.9016323452565 1.43092834643601e-14 -1.70322432049595 4.43562078746451e-23 mirMAP -0.248469992524147 1.46624879489722e-13 NA NA NA hsa-miR-34a-5p ITPR2 1.9016323452565 1.43092834643601e-14 -0.177554271932524 0.436106439712671 MirTarget -0.204451958085315 1.90493212189564e-06 NA NA NA hsa-miR-140-5p ITSN1 0.844753502512594 3.73722278438606e-05 -0.611059124760145 8.82737803628848e-05 miRanda -0.130965294277461 0.00038814767292049 NA NA NA hsa-miR-34a-5p ITSN1 1.9016323452565 1.43092834643601e-14 -0.611059124760145 8.82737803628848e-05 mirMAP -0.166162472068446 1.55411816510568e-08 NA NA NA hsa-miR-34a-5p JAKMIP1 1.9016323452565 1.43092834643601e-14 0.374468407061645 0.504232790948634 MirTarget;miRNATAP -0.278669647531769 0.00900854053605573 NA NA NA hsa-miR-34a-5p JMJD1C 1.9016323452565 1.43092834643601e-14 -0.840910081913005 7.98664644216222e-07 miRNATAP -0.157207821622443 1.28804548834048e-06 NA NA NA hsa-miR-140-5p KANK1 0.844753502512594 3.73722278438606e-05 -1.71701001900807 7.40785753705277e-11 miRanda -0.336562898716743 9.16906166787748e-08 NA NA NA hsa-miR-34a-5p KCNAB2 1.9016323452565 1.43092834643601e-14 -0.720387769910192 0.0156755477759335 MirTarget;mirMAP -0.311627519483046 2.73286475641682e-08 NA NA NA hsa-miR-34a-5p KCNK3 1.9016323452565 1.43092834643601e-14 -3.6338132446768 1.0612212729052e-10 MirTarget -0.571573366414864 1.32401052672489e-07 NA NA NA hsa-miR-140-5p KCNK6 0.844753502512594 3.73722278438606e-05 -0.905061621484429 0.000240902228030551 miRanda -0.259270622610629 8.37443303048348e-06 NA NA NA hsa-miR-34a-5p KCNQ4 1.9016323452565 1.43092834643601e-14 -2.63982014948538 9.7947726847549e-09 mirMAP -0.693583712977992 9.27954465587282e-16 NA NA NA hsa-miR-140-5p KCTD11 0.844753502512594 3.73722278438606e-05 -0.503934145323768 0.0275578573495853 miRanda -0.208863617743653 0.0001052464821602 NA NA NA hsa-miR-140-5p KCTD16 0.844753502512594 3.73722278438606e-05 -0.0375082886752001 0.93511794629281 miRanda -0.315845286492416 0.00368230364932637 NA NA NA hsa-miR-140-5p KCTD18 0.844753502512594 3.73722278438606e-05 -0.434489365464001 0.00117568779025694 miRanda -0.15816284203572 4.51176440016077e-07 NA NA NA hsa-miR-194-5p KCTD20 1.8992998339217 3.76507853301977e-10 -0.81380310423214 2.36532656017097e-06 MirTarget -0.130157077712361 1.415003685133e-06 NA NA NA hsa-miR-140-5p KCTD3 0.844753502512594 3.73722278438606e-05 -0.557766388176278 0.000666953388579478 miRanda -0.13598344065324 0.000450028955282042 NA NA NA hsa-miR-140-5p KIAA0232 0.844753502512594 3.73722278438606e-05 -1.01288774232377 1.38634064133044e-11 miRanda -0.155833945617373 1.48914553840539e-05 NA NA NA hsa-miR-152-3p KIAA0232 -0.0480232621705712 0.844347735441565 -1.01288774232377 1.38634064133044e-11 MirTarget -0.130329647628463 1.72494641474132e-05 NA NA NA hsa-miR-152-3p KIAA0430 -0.0480232621705712 0.844347735441565 -0.746195966712634 1.44948647002737e-09 MirTarget -0.107955941551247 1.31533856050393e-05 NA NA NA hsa-miR-140-5p KIAA0586 0.844753502512594 3.73722278438606e-05 -0.371016106857657 0.0202946510265247 miRanda -0.194665616153626 1.83126503504459e-07 NA NA NA hsa-miR-140-5p KIAA0754 0.844753502512594 3.73722278438606e-05 -1.10539342428913 0.00843414050177564 miRanda -0.22251419983745 0.0255547671416751 NA NA NA hsa-miR-140-5p KIAA1109 0.844753502512594 3.73722278438606e-05 -0.786927464209296 5.14611805018903e-06 miRanda -0.179326348387264 1.15161131518352e-05 NA NA NA hsa-miR-152-3p KIAA1324L -0.0480232621705712 0.844347735441565 0.0967790439765293 0.692626706520328 MirTarget -0.135837065009002 0.00524508986913591 NA NA NA hsa-miR-34a-5p KIAA1462 1.9016323452565 1.43092834643601e-14 -1.7207439664468 1.06773819784283e-07 MirTarget -0.430496028061196 1.74494966464615e-12 NA NA NA hsa-miR-152-3p KIAA1468 -0.0480232621705712 0.844347735441565 -0.0123799916423781 0.94521165139995 MirTarget -0.184761435380527 1.72169627381361e-07 NA NA NA hsa-miR-194-5p KIAA1644 1.8992998339217 3.76507853301977e-10 -4.40439862301283 1.42085780669109e-16 mirMAP -0.902460440284504 8.70416175585365e-29 NA NA NA hsa-miR-34a-5p KIAA1644 1.9016323452565 1.43092834643601e-14 -4.40439862301283 1.42085780669109e-16 MirTarget -0.985302403515769 7.6388906367849e-23 NA NA NA hsa-miR-140-5p KIF13A 0.844753502512594 3.73722278438606e-05 -1.2222279491778 3.03312683064576e-07 miRanda -0.280921540216584 6.9313220584557e-07 NA NA NA hsa-miR-140-5p KIF1B 0.844753502512594 3.73722278438606e-05 -0.678468502639348 1.60841697720107e-05 miRanda -0.137889162374597 0.000218744554234277 NA NA NA hsa-miR-194-5p KIF1B 1.8992998339217 3.76507853301977e-10 -0.678468502639348 1.60841697720107e-05 mirMAP -0.115766995909298 2.44530368135376e-06 NA NA NA hsa-miR-34a-5p KIF2A 1.9016323452565 1.43092834643601e-14 -0.215409671865721 0.231461115751439 miRNAWalker2_validate -0.169504620039035 5.40570822486798e-07 NA NA NA hsa-miR-34a-5p KIF5B 1.9016323452565 1.43092834643601e-14 -0.636463278164481 1.60031466459174e-06 miRNAWalker2_validate -0.121805938075758 1.35627819704988e-06 NA NA NA hsa-miR-34a-5p KIT 1.9016323452565 1.43092834643601e-14 -2.52159771280238 8.03290749995369e-07 MirTarget -0.312332886384761 0.00150658023755356 NA NA NA hsa-miR-34a-5p KITLG 1.9016323452565 1.43092834643601e-14 -1.58421888595384 1.26958469493711e-05 MirTarget -0.471477676973797 4.5117297895647e-12 NA NA NA hsa-miR-140-5p KLB 0.844753502512594 3.73722278438606e-05 -0.338377806559947 0.274095540948069 miRanda -0.162189950811379 0.0267036637775793 NA NA NA hsa-miR-140-5p KLC1 0.844753502512594 3.73722278438606e-05 -0.608227882601959 2.78949652074599e-07 miRanda -0.106640885229892 0.000149230749811732 NA NA NA hsa-miR-34a-5p KLC1 1.9016323452565 1.43092834643601e-14 -0.608227882601959 2.78949652074599e-07 miRNAWalker2_validate -0.120553713572346 7.85293803286174e-08 NA NA NA hsa-miR-194-5p KLF12 1.8992998339217 3.76507853301977e-10 -1.46917100719464 1.42059321169598e-05 MirTarget -0.321237021456746 9.73843577287755e-10 NA NA NA hsa-miR-34a-5p KLF13 1.9016323452565 1.43092834643601e-14 -1.16141618366409 1.36372480238947e-05 mirMAP -0.347302984351715 4.10397341226692e-12 NA NA NA hsa-miR-34a-5p KLF4 1.9016323452565 1.43092834643601e-14 -2.66899133268835 3.11667300306613e-16 MirTarget;miRNATAP -0.147421843483855 0.0225947171913702 NA NA NA hsa-miR-140-5p KLF5 0.844753502512594 3.73722278438606e-05 0.854642298355865 0.0205773648492263 miRanda -0.215567010599725 0.0137477581085816 NA NA NA hsa-miR-194-5p KLF7 1.8992998339217 3.76507853301977e-10 -0.396294178926278 0.170315776862033 miRNATAP -0.282916402140378 1.73275277003317e-10 NA NA NA hsa-miR-34a-5p KLF7 1.9016323452565 1.43092834643601e-14 -0.396294178926278 0.170315776862033 miRNATAP -0.378490603262785 1.69793480441075e-12 NA NA NA hsa-miR-152-3p KLHL17 -0.0480232621705712 0.844347735441565 1.22450281544096 1.1803019645397e-07 MirTarget -0.133252592532251 0.00431895573376549 NA NA NA hsa-miR-140-5p KRT77 0.844753502512594 3.73722278438606e-05 1.08980666735016 0.13813805777599 miRanda -0.35776520000996 0.0399879200657293 NA NA NA hsa-miR-34a-5p KY 1.9016323452565 1.43092834643601e-14 -3.92273615985382 4.39505790976942e-15 MirTarget -0.784704461120385 1.63081634698696e-16 NA NA NA hsa-miR-140-5p LAMC1 0.844753502512594 3.73722278438606e-05 -0.820359806292778 9.59613230767155e-05 MirTarget;PITA;miRanda;miRNATAP -0.187818567265583 0.000164349930813064 NA NA NA hsa-miR-140-5p LANCL3 0.844753502512594 3.73722278438606e-05 0.0755727081400549 0.850279860558265 miRanda -0.202250368097437 0.0327181850528045 NA NA NA hsa-miR-194-5p LATS1 1.8992998339217 3.76507853301977e-10 -0.728264634976516 0.00251777297344159 miRNATAP -0.108848605291542 0.00400268569989429 NA NA NA hsa-miR-140-5p LCOR 0.844753502512594 3.73722278438606e-05 -0.359527177530246 0.275906917620475 miRNATAP -0.247574076732951 0.0014686136177839 NA NA NA hsa-miR-140-5p LDB3 0.844753502512594 3.73722278438606e-05 -3.78725573134894 2.18182402606317e-20 miRanda -0.3453884963073 0.000653562393268843 NA NA NA hsa-miR-34a-5p LDHA 1.9016323452565 1.43092834643601e-14 0.407908079011101 0.0898840708480306 miRNAWalker2_validate;MirTarget;miRNATAP -0.192159149787817 2.38615615832768e-05 26902416;25333573;27186405 The miR 34a LDHA axis regulates glucose metabolism and tumor growth in breast cancer; We also performed luciferase reporter assays and found that LDHA was a direct target of miR-34a; Repression of LDHA by miR-34a suppressed glycolysis and cell proliferation in breast cancer cells in vitro; Our findings provide clues regarding the role of miR-34a as a tumor suppressor in breast cancer through the inhibition of LDHA both in vitro and in vivo; Targeting LDHA through miR-34a could be a potential therapeutic strategy in breast cancer;Inhibition of lactate dehydrogenase A by microRNA 34a resensitizes colon cancer cells to 5 fluorouracil; Furthermore LDHA was shown to be a direct target of miR-34a; Overexpression of miR-34a reduced the expression of LDHA probably through binding to the 3' untranslated region leading to the re-sensitization of 5-FU-resistant cancer cells to 5-FU; In conclusion the current study showed that miR-34a is involved in sensitivity to 5-FU in part through its effects on LDHA expression;HPV E6/p53 mediated down regulation of miR 34a inhibits Warburg effect through targeting LDHA in cervical cancer; Subsequently lactate dehydrogenase A LDHA which catalyzes the last key step in glycolysis was identified as a direct target of miR-34a; Silencing of LDHA or introduction of miR-34a significantly attenuated colony formation ability and invasive capacity of SiHa and HeLa cells and these effects were fully compromised by reintroduction of LDHA ;; breast cancer;colon cancer;cervical and endocervical cancer hsa-miR-140-5p LEPROT 0.844753502512594 3.73722278438606e-05 -0.817800808666002 0.00547149005556457 miRanda -0.158493201345761 0.0233654945346767 NA NA NA hsa-miR-140-5p LGR5 0.844753502512594 3.73722278438606e-05 0.822108018087351 0.254769078971915 miRanda -0.468858982163634 0.00600714684658622 NA NA NA hsa-miR-140-5p LGR6 0.844753502512594 3.73722278438606e-05 -2.83111128607292 1.75135870176748e-06 miRanda -0.485740181317537 0.000593715120436797 NA NA NA hsa-miR-34a-5p LHX2 1.9016323452565 1.43092834643601e-14 2.06856057446591 0.000890579247157729 miRNATAP -0.263219666179235 0.0274145216141966 NA NA NA hsa-miR-194-5p LINGO2 1.8992998339217 3.76507853301977e-10 -1.99110914968633 0.00050913147948199 MirTarget;miRNATAP -0.411480124357607 4.23975823234345e-06 NA NA NA hsa-miR-140-5p LMTK2 0.844753502512594 3.73722278438606e-05 -0.618611491521039 0.0308746415319932 miRanda -0.14177083538567 0.0369342973327228 NA NA NA hsa-miR-194-5p LNPEP 1.8992998339217 3.76507853301977e-10 -0.552309477369569 0.0283916452484756 mirMAP -0.172730186777074 1.04177573716778e-05 NA NA NA hsa-miR-140-5p LNX2 0.844753502512594 3.73722278438606e-05 -0.126871700008468 0.468377324967028 miRanda -0.18093354466452 9.89178833703731e-06 NA NA NA hsa-miR-34a-5p LOXL3 1.9016323452565 1.43092834643601e-14 -0.968455677583596 0.000809448004647299 MirTarget;miRNATAP -0.400597917013039 9.32832039663351e-14 NA NA NA hsa-miR-140-5p LPP 0.844753502512594 3.73722278438606e-05 -2.04092311415528 2.98839088727532e-15 miRanda -0.452774663889973 1.94937051820526e-13 NA NA NA hsa-miR-194-5p LPP 1.8992998339217 3.76507853301977e-10 -2.04092311415528 2.98839088727532e-15 mirMAP -0.281165782620271 6.37211152419254e-12 NA NA NA hsa-miR-194-5p LPXN 1.8992998339217 3.76507853301977e-10 -0.586907358322783 0.0459806645042256 MirTarget -0.155473210801614 0.000714233119409315 NA NA NA hsa-miR-140-5p LRBA 0.844753502512594 3.73722278438606e-05 -0.114506389536762 0.531257994781299 miRanda -0.165815640522583 0.000111742496913339 NA NA NA hsa-miR-34a-5p LRCH1 1.9016323452565 1.43092834643601e-14 -1.09367192084794 2.38111166969073e-11 MirTarget -0.240044825488938 7.82870694753625e-15 NA NA NA hsa-miR-194-5p LRCH2 1.8992998339217 3.76507853301977e-10 -2.83984975921435 2.14431508265196e-12 MirTarget -0.51185173071156 3.75042607468895e-16 NA NA NA hsa-miR-140-5p LRRC37A2 0.844753502512594 3.73722278438606e-05 0.0198558429800575 0.929194181671019 miRanda -0.103946897666168 0.049050838268701 NA NA NA hsa-miR-34a-5p LRRC40 1.9016323452565 1.43092834643601e-14 -0.0455784335637732 0.755138358864283 miRNAWalker2_validate;MirTarget -0.106025955765025 0.000119907432013954 NA NA NA hsa-miR-34a-5p LRRC7 1.9016323452565 1.43092834643601e-14 -3.91787209255121 5.73746646820421e-15 MirTarget -0.578343713139293 2.7252019018456e-09 NA NA NA hsa-miR-194-5p LRRFIP1 1.8992998339217 3.76507853301977e-10 -1.15698960634805 2.40467433722313e-13 MirTarget;miRNATAP -0.118860810335139 2.35694831594271e-06 NA NA NA hsa-miR-140-5p LYST 0.844753502512594 3.73722278438606e-05 -0.882294152711769 1.32902764923941e-05 miRanda -0.123990603294225 0.0102929419679281 NA NA NA hsa-miR-194-5p MAF 1.8992998339217 3.76507853301977e-10 -1.28341922239874 0.00015825213662883 miRNATAP -0.440617899042183 1.20402003231927e-17 NA NA NA hsa-miR-140-5p MAGEE1 0.844753502512594 3.73722278438606e-05 -0.810493365602985 0.0131022798867108 miRanda -0.156415301732732 0.0437249756463868 NA NA NA hsa-miR-152-3p MAGI1 -0.0480232621705712 0.844347735441565 -0.743475152574216 0.0282551151431016 MirTarget -0.354189539485224 1.13758836758581e-07 NA NA NA hsa-miR-140-5p MAGI2 0.844753502512594 3.73722278438606e-05 -1.89478051791337 8.17403291700624e-13 miRanda;miRNATAP -0.268907956055265 2.63351131256175e-05 NA NA NA hsa-miR-140-5p MAGI3 0.844753502512594 3.73722278438606e-05 -0.857868846049644 2.81850329980257e-05 miRanda -0.20120962576751 3.37300588774503e-05 NA NA NA hsa-miR-152-3p MAGIX -0.0480232621705712 0.844347735441565 0.815827375417684 0.035298402537912 MirTarget -0.486655112637027 1.35457087718111e-10 NA NA NA hsa-miR-140-5p MAN1A2 0.844753502512594 3.73722278438606e-05 -0.262651432722437 0.148904669417439 miRanda -0.112361023764423 0.00888890721909246 NA NA NA hsa-miR-140-5p MANBAL 0.844753502512594 3.73722278438606e-05 -0.121332666011552 0.294691123769374 miRanda -0.103720828251068 0.000127840321871016 NA NA NA hsa-miR-34a-5p MAP1A 1.9016323452565 1.43092834643601e-14 -2.81936532211288 1.95093328905874e-14 MirTarget;miRNATAP -0.631471488247341 8.54216775732896e-20 NA NA NA hsa-miR-194-5p MAP1B 1.8992998339217 3.76507853301977e-10 -3.18358434812783 4.83606017602339e-16 MirTarget -0.573945905242841 3.44883729029071e-21 NA NA NA hsa-miR-34a-5p MAP1B 1.9016323452565 1.43092834643601e-14 -3.18358434812783 4.83606017602339e-16 miRNAWalker2_validate -0.786803751441067 2.86731642139992e-27 NA NA NA hsa-miR-194-5p MAP2 1.8992998339217 3.76507853301977e-10 -0.753572928246066 0.0970780637395552 MirTarget;miRNATAP -0.278466329005266 8.32899807077198e-05 NA NA NA hsa-miR-140-5p MAP3K12 0.844753502512594 3.73722278438606e-05 -0.856121644680553 0.00031269192719719 miRanda -0.123297274132473 0.0292376022369516 NA NA NA hsa-miR-34a-5p MAP3K14 1.9016323452565 1.43092834643601e-14 -0.929542138683687 1.31735308419243e-05 MirTarget -0.168509021928338 3.5079349902853e-05 NA NA NA hsa-miR-194-5p MAP3K3 1.8992998339217 3.76507853301977e-10 -0.867302315651695 4.69975718275905e-09 miRNATAP -0.190921704069272 3.77942465212339e-17 NA NA NA hsa-miR-140-5p MAP4 0.844753502512594 3.73722278438606e-05 -0.677894471246955 4.08007924790953e-07 miRanda -0.117822141538409 0.000214078864423586 NA NA NA hsa-miR-34a-5p MAP4 1.9016323452565 1.43092834643601e-14 -0.677894471246955 4.08007924790953e-07 miRNAWalker2_validate -0.147266445783703 6.04997841521672e-09 NA NA NA hsa-miR-34a-5p MAP4K4 1.9016323452565 1.43092834643601e-14 0.130872521838526 0.522814141079271 MirTarget -0.259802212401119 8.07915118814483e-12 NA NA NA hsa-miR-34a-5p MAPK1 1.9016323452565 1.43092834643601e-14 -0.300413846088826 0.0202503240217449 mirMAP -0.113934200811126 2.89029232507908e-06 NA NA NA hsa-miR-140-5p MAPK4 0.844753502512594 3.73722278438606e-05 -3.72102537270416 5.14282599876177e-08 miRanda -0.647921450937081 7.35784052037252e-05 NA NA NA hsa-miR-34a-5p MAPT 1.9016323452565 1.43092834643601e-14 -2.57854469569689 1.03709852332835e-08 MirTarget;miRNATAP -0.387660765401499 7.71091072422528e-06 NA NA NA hsa-miR-140-5p MBLAC2 0.844753502512594 3.73722278438606e-05 -0.34147077589088 0.0792191885727804 miRanda -0.157806592260956 0.000573373126635245 NA NA NA hsa-miR-140-5p MCC 0.844753502512594 3.73722278438606e-05 -1.13976055087047 0.000453102417948938 mirMAP -0.194810611574821 0.0117643766199839 NA NA NA hsa-miR-194-5p MCFD2 1.8992998339217 3.76507853301977e-10 -0.273710952309139 0.0802130111446696 mirMAP -0.133022575293091 3.36065041870111e-08 NA NA NA hsa-miR-34a-5p MCFD2 1.9016323452565 1.43092834643601e-14 -0.273710952309139 0.0802130111446696 miRNATAP -0.192772321331484 3.36229390696629e-11 NA NA NA hsa-miR-34a-5p MCTP1 1.9016323452565 1.43092834643601e-14 -0.930962901937398 0.0391633392445751 miRNATAP -0.475205056199198 2.12844533170181e-08 NA NA NA hsa-miR-34a-5p MDGA1 1.9016323452565 1.43092834643601e-14 -1.00154386684221 0.0303398006837731 mirMAP -0.549905797426372 2.04266806479283e-10 NA NA NA hsa-miR-152-3p MDM4 -0.0480232621705712 0.844347735441565 -0.0417166726103293 0.796356265058254 MirTarget -0.198828633232754 2.62918534012835e-10 NA NA NA hsa-miR-34a-5p ME1 1.9016323452565 1.43092834643601e-14 -1.33126432667221 0.000244521518404576 miRNAWalker2_validate -0.518143353901709 1.60766756065236e-14 NA NA NA hsa-miR-194-5p MEF2C 1.8992998339217 3.76507853301977e-10 -2.13436808535659 1.07833769123274e-14 miRNATAP -0.286415328426924 5.8412897687808e-11 NA NA NA hsa-miR-140-5p MEGF9 0.844753502512594 3.73722278438606e-05 -0.640753905897188 0.00228374865870751 miRanda -0.172755982710845 0.000504252833997945 NA NA NA hsa-miR-194-5p MEIS2 1.8992998339217 3.76507853301977e-10 -1.72135417174124 5.81040155633491e-11 MirTarget;miRNATAP -0.27040913947991 5.41984279024942e-11 NA NA NA hsa-miR-34a-5p MGAT5B 1.9016323452565 1.43092834643601e-14 -0.359608389802055 0.458048727881491 MirTarget;miRNATAP -0.222488785718032 0.0158950552804138 NA NA NA hsa-miR-140-5p MGST2 0.844753502512594 3.73722278438606e-05 0.139071658396039 0.543630587864055 miRanda -0.119435608834735 0.0272854447130922 NA NA NA hsa-miR-140-5p MIPOL1 0.844753502512594 3.73722278438606e-05 -0.465390490804916 0.0798096514855633 PITA;miRanda;miRNATAP -0.234226943287348 0.000181174790942068 NA NA NA hsa-miR-140-5p MLLT10 0.844753502512594 3.73722278438606e-05 -0.12255797191423 0.369125463218164 miRanda -0.102425771110098 0.0013946823401745 NA NA NA hsa-miR-34a-5p MLLT3 1.9016323452565 1.43092834643601e-14 -0.649777649033278 0.0222203114424632 MirTarget;miRNATAP -0.187377477462236 0.000522685788785214 NA NA NA hsa-miR-152-3p MMP15 -0.0480232621705712 0.844347735441565 0.933840295385473 0.000401388643424283 MirTarget -0.309459665480188 2.63470126713117e-09 NA NA NA hsa-miR-140-5p MOAP1 0.844753502512594 3.73722278438606e-05 -1.0400964433585 2.62319898449648e-13 miRanda -0.177259042070279 2.06955758160759e-07 NA NA NA hsa-miR-140-5p MORC3 0.844753502512594 3.73722278438606e-05 -0.298173629571488 0.0653951052987779 miRanda -0.125966203170978 0.000946804190840181 NA NA NA hsa-miR-34a-5p MPP2 1.9016323452565 1.43092834643601e-14 -1.4560422878474 0.000139696972689277 MirTarget;miRNATAP -0.330788230229271 5.4137231125192e-06 NA NA NA hsa-miR-140-5p MPP5 0.844753502512594 3.73722278438606e-05 -0.26222079257503 0.0658846907584883 miRanda -0.115737023362252 0.000554223806366612 NA NA NA hsa-miR-140-5p MPP7 0.844753502512594 3.73722278438606e-05 -1.59515432384645 5.42791218884888e-06 miRanda -0.414005194102235 6.05641837799452e-07 NA NA NA hsa-miR-152-3p MPPED2 -0.0480232621705712 0.844347735441565 -2.49636344581898 4.3689800525089e-05 MirTarget -0.392195175801767 0.00137421664046177 NA NA NA hsa-miR-140-5p MPZL2 0.844753502512594 3.73722278438606e-05 0.600763767567831 0.0695232251763268 miRanda -0.198297706903185 0.0113704861318317 NA NA NA hsa-miR-140-5p MR1 0.844753502512594 3.73722278438606e-05 0.160187899178531 0.456728268620272 miRanda -0.163476545850216 0.00125827512970767 NA NA NA hsa-miR-152-3p MTMR14 -0.0480232621705712 0.844347735441565 0.588911829136585 1.35382666706849e-05 MirTarget -0.116535935419013 1.51366658833546e-05 NA NA NA hsa-miR-34a-5p MTMR2 1.9016323452565 1.43092834643601e-14 -0.0692560870120555 0.555584242644447 miRNAWalker2_validate -0.1002204236336 5.42625596882733e-06 NA NA NA hsa-miR-152-3p MTMR3 -0.0480232621705712 0.844347735441565 -0.161535300596079 0.278552827483475 MirTarget -0.125726965898786 1.88487225595255e-05 NA NA NA hsa-miR-34a-5p MTMR9 1.9016323452565 1.43092834643601e-14 -0.836073789582016 3.17094975834284e-09 miRNAWalker2_validate -0.139182461106227 2.50493901668674e-07 NA NA NA hsa-miR-140-5p MTR 0.844753502512594 3.73722278438606e-05 -0.555439559020076 4.10110160901206e-05 miRanda -0.126792223768934 7.43625100181466e-05 NA NA NA hsa-miR-152-3p MTSS1L -0.0480232621705712 0.844347735441565 -0.348149667750587 0.109728230271104 MirTarget -0.122513315230441 0.00466467250232449 NA NA NA hsa-miR-140-5p MTUS1 0.844753502512594 3.73722278438606e-05 -0.925659101894674 9.09511999956855e-05 miRanda -0.206813911618785 0.000227318643483425 NA NA NA hsa-miR-34a-5p MYADM 1.9016323452565 1.43092834643601e-14 -2.82656540386901 8.49316181730987e-14 MirTarget -0.48421438979298 2.90524776288772e-11 NA NA NA hsa-miR-34a-5p MYC 1.9016323452565 1.43092834643601e-14 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate;miRTarBase -0.359767953473847 5.62932761832786e-07 25572695;25686834;21460242;22159222;23640973;22830357;22235332 The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;miR 34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c Myc pathway;Myc mediated repression of microRNA 34a promotes high grade transformation of B cell lymphoma by dysregulation of FoxP1;MicroRNA 34a suppresses malignant transformation by targeting c Myc transcriptional complexes in human renal cell carcinoma; We investigated the functional effects of microRNA-34a miR-34a on c-Myc transcriptional complexes in renal cell carcinoma; miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region which was revealed by luciferase reporter assays; Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription indicating a novel role of miR-34a in the regulation of transcription by c-Myc;Among them miR-34a was also associated with poor prognosis in 2 independent series of leukemic and nodal MCL and in cooperation with high expression of the MYC oncogene;We report that miR-34a did not inhibit cell proliferation notwithstanding a marked down-regulation of c-MYC;MicroRNA 34a modulates c Myc transcriptional complexes to suppress malignancy in human prostate cancer cells; We studied the functional effects of miR-34a on c-Myc transcriptional complexes in PC-3 prostate cancer cells; miR-34a downregulated expression of c-Myc oncogene by targeting its 3' UTR as shown by luciferase reporter assays; This is the first report to document that miR-34a suppresses assembly and function of the c-Myc-Skp2-Miz1 complex that activates RhoA and the c-Myc-pTEFB complex that elongates transcription of various genes suggesting a novel role of miR-34a in the regulation of transcription by c-Myc complex ;;;malignant trasformation;worse prognosis;; bladder cancer;liver cancer;B cell lymphoma;kidney renal cell cancer;lymphoma;lymphoma;prostate cancer hsa-miR-140-5p MYCBP2 0.844753502512594 3.73722278438606e-05 -0.799049389391067 3.8436887931124e-05 MirTarget;PITA;miRanda -0.135970281283385 0.00323625928714402 NA NA NA hsa-miR-194-5p MYH10 1.8992998339217 3.76507853301977e-10 -0.113066852038276 0.614876476546525 miRNATAP -0.130095787355147 0.000197612356385024 NA NA NA hsa-miR-140-5p MYO3B 0.844753502512594 3.73722278438606e-05 -0.381913745671954 0.573472947560902 miRanda -0.52707326580289 0.000985032185651081 NA NA NA hsa-miR-194-5p MYO5A 1.8992998339217 3.76507853301977e-10 -0.274576441491861 0.311620335084615 mirMAP -0.319076731008915 8.5124117049572e-15 NA NA NA hsa-miR-140-5p MYO9A 0.844753502512594 3.73722278438606e-05 -1.29622192336459 1.1786138431555e-06 miRanda -0.2649805963607 2.96896495629263e-05 NA NA NA hsa-miR-140-5p NAALADL2 0.844753502512594 3.73722278438606e-05 -0.947809069712676 0.0524656764430156 MirTarget;PITA;miRanda -0.378300104821935 0.0010519545689171 NA NA NA hsa-miR-194-5p NAB1 1.8992998339217 3.76507853301977e-10 -0.514150135728658 0.0094706782461599 MirTarget -0.104563682252344 0.000734237663616554 NA NA NA hsa-miR-34a-5p NAV1 1.9016323452565 1.43092834643601e-14 -0.418200324441875 0.108742163308665 MirTarget;miRNATAP -0.317572593313379 6.3486197910259e-11 NA NA NA hsa-miR-34a-5p NAV3 1.9016323452565 1.43092834643601e-14 -3.21771083204903 7.35356644104861e-11 MirTarget -0.717888709443055 1.55652183905208e-14 NA NA NA hsa-miR-194-5p NBEA 1.8992998339217 3.76507853301977e-10 -3.53497100925373 1.98262703308568e-12 miRNATAP -0.356884749777886 8.72929652059472e-06 NA NA NA hsa-miR-140-5p NBEAL1 0.844753502512594 3.73722278438606e-05 -0.821950697692343 0.00430349720642684 miRanda -0.266816829174841 8.62948281709976e-05 NA NA NA hsa-miR-140-5p NBPF10 0.844753502512594 3.73722278438606e-05 -0.95665316939048 0.00235890681540488 miRanda -0.160896936662332 0.0314664096421279 NA NA NA hsa-miR-140-5p NCKAP1 0.844753502512594 3.73722278438606e-05 -0.379776690350136 0.0142403675794927 MirTarget;PITA;miRanda -0.204577822883 1.41886877780599e-08 NA NA NA hsa-miR-152-3p NCKIPSD -0.0480232621705712 0.844347735441565 0.519796442537032 0.000473584736327166 MirTarget -0.110492942905652 0.000187905148698125 NA NA NA hsa-miR-140-5p NCOR1 0.844753502512594 3.73722278438606e-05 -0.697475661075322 7.56012496866254e-05 miRanda -0.204842865617412 7.91676578258419e-07 NA NA NA hsa-miR-34a-5p NCOR2 1.9016323452565 1.43092834643601e-14 -0.35204425841984 0.0178506335854312 MirTarget -0.157919625529881 1.41350087236073e-08 NA NA NA hsa-miR-140-5p NCS1 0.844753502512594 3.73722278438606e-05 -1.7356703955299 3.35229307090603e-12 miRNATAP -0.273129875587118 5.39561901868239e-06 NA NA NA hsa-miR-34a-5p NDST1 1.9016323452565 1.43092834643601e-14 -0.250883286824299 0.176743296307116 MirTarget;miRNATAP -0.152337669911294 1.37515709369466e-05 NA NA NA hsa-miR-140-5p NEK7 0.844753502512594 3.73722278438606e-05 -0.67612638701862 0.000464017404633991 miRanda -0.201544133541836 9.56733335856734e-06 NA NA NA hsa-miR-140-5p NEK9 0.844753502512594 3.73722278438606e-05 -0.68505771922002 5.87748183701095e-07 miRanda -0.13950519024815 1.78724125137199e-05 NA NA NA hsa-miR-152-3p NEURL4 -0.0480232621705712 0.844347735441565 -0.0584750451510274 0.635475170192213 MirTarget -0.129982146145305 6.96154513432467e-08 NA NA NA hsa-miR-34a-5p NFAM1 1.9016323452565 1.43092834643601e-14 -0.407436496682177 0.299538525694089 MirTarget -0.274202481638733 0.000230184082966138 NA NA NA hsa-miR-140-5p NFASC 0.844753502512594 3.73722278438606e-05 -2.95717922837883 4.31475260476481e-14 miRanda -0.323265012012021 0.000701122876024732 NA NA NA hsa-miR-34a-5p NFASC 1.9016323452565 1.43092834643601e-14 -2.95717922837883 4.31475260476481e-14 mirMAP -0.586182373828648 3.80269106863198e-15 22292433 Transcriptional activation of microRNA 34a by NF kappa B in human esophageal cancer cells esophageal cancer hsa-miR-34a-5p NFE2L1 1.9016323452565 1.43092834643601e-14 -0.171483758009488 0.176829520001656 MirTarget;miRNATAP -0.125397282103513 1.30424037317666e-07 NA NA NA hsa-miR-140-5p NFE2L2 0.844753502512594 3.73722278438606e-05 -0.965983722918669 1.89554271251606e-08 MirTarget;PITA;miRanda -0.153794517487273 0.000181411736238778 NA NA NA hsa-miR-140-5p NFIC 0.844753502512594 3.73722278438606e-05 -1.57099939804843 8.09399770340134e-09 mirMAP -0.265761408491642 4.59025448124793e-05 NA NA NA hsa-miR-34a-5p NFIC 1.9016323452565 1.43092834643601e-14 -1.57099939804843 8.09399770340134e-09 mirMAP -0.433163394592829 1.52890240175384e-17 NA NA NA hsa-miR-140-5p NFIX 0.844753502512594 3.73722278438606e-05 -2.14500078402438 1.46783312646863e-14 mirMAP -0.221466564040081 0.00112971785539202 NA NA NA hsa-miR-34a-5p NGFR 1.9016323452565 1.43092834643601e-14 -2.71562668756498 2.85979409356053e-06 mirMAP -0.651447322603427 3.13859594639451e-09 NA NA NA hsa-miR-152-3p NHS -0.0480232621705712 0.844347735441565 -0.628990775445834 0.0381565663055585 MirTarget -0.120597554423587 0.0466439256923687 NA NA NA hsa-miR-140-5p NKD1 0.844753502512594 3.73722278438606e-05 -1.69553775455222 4.2654677240011e-05 miRanda -0.379888847864967 0.000112585187849131 NA NA NA hsa-miR-140-5p NLGN1 0.844753502512594 3.73722278438606e-05 -3.85451324230728 2.71835497219559e-12 miRanda -0.392090390632934 0.00341188817450937 NA NA NA hsa-miR-152-3p NLK -0.0480232621705712 0.844347735441565 0.7741568824418 1.00090143680282e-07 MirTarget -0.132317012289272 5.31854788819065e-06 NA NA NA hsa-miR-140-5p NME4 0.844753502512594 3.73722278438606e-05 -0.411204472910856 0.0381759064710997 miRanda -0.144745520597351 0.0019928830106584 NA NA NA hsa-miR-34a-5p NNT 1.9016323452565 1.43092834643601e-14 -0.403871740015822 0.0362553547619169 miRNAWalker2_validate -0.155593680180507 1.97939514593657e-05 NA NA NA hsa-miR-34a-5p NOTCH2 1.9016323452565 1.43092834643601e-14 -0.649665466220466 0.00179668614494204 miRNAWalker2_validate;miRNATAP -0.276940453993645 8.61027725147104e-13 NA NA NA hsa-miR-152-3p NPEPL1 -0.0480232621705712 0.844347735441565 0.155183796089934 0.378197637161532 MirTarget -0.209162034415816 1.15764957664514e-09 NA NA NA hsa-miR-34a-5p NPTX1 1.9016323452565 1.43092834643601e-14 -3.0548528465665 5.58655593069716e-09 miRNATAP -0.485830851335166 1.41314121745096e-06 NA NA NA hsa-miR-140-5p NPY6R 0.844753502512594 3.73722278438606e-05 -4.32071853591013 4.00338983758274e-18 miRanda -0.703211849598026 6.12983806287026e-09 NA NA NA hsa-miR-140-5p NR1D1 0.844753502512594 3.73722278438606e-05 -0.306170932808354 0.192043866487942 PITA;miRanda -0.232739238502515 2.3837578277056e-05 NA NA NA hsa-miR-152-3p NR2C2AP -0.0480232621705712 0.844347735441565 1.07756496920148 7.95649346751232e-13 MirTarget -0.117867626661291 0.00011805944119792 NA NA NA hsa-miR-194-5p NRP1 1.8992998339217 3.76507853301977e-10 -0.612408058927576 0.0291452451283254 miRNATAP -0.273636944982484 2.23856759751382e-10 NA NA NA hsa-miR-140-5p NRXN3 0.844753502512594 3.73722278438606e-05 -1.80936143811568 0.00413877637347812 miRanda -0.497127602323677 0.00088095942850305 NA NA NA hsa-miR-34a-5p NSD1 1.9016323452565 1.43092834643601e-14 -0.140278049651839 0.313165028415798 miRNATAP -0.115584242688162 9.97030291056323e-06 NA NA NA hsa-miR-140-5p NT5DC3 0.844753502512594 3.73722278438606e-05 -1.57113195555251 4.4392449166802e-10 miRanda -0.164339210362627 0.00687983129217766 NA NA NA hsa-miR-34a-5p NT5E 1.9016323452565 1.43092834643601e-14 -1.32095136217544 0.00557630949266939 miRNAWalker2_validate -0.409646516674786 5.76417595066467e-06 NA NA NA hsa-miR-140-5p NTN1 0.844753502512594 3.73722278438606e-05 -2.90496349995287 8.65251378142323e-09 mirMAP -0.294542120700473 0.0154890254176955 NA NA NA hsa-miR-34a-5p NTN1 1.9016323452565 1.43092834643601e-14 -2.90496349995287 8.65251378142323e-09 mirMAP -0.605001166287899 2.97419227887426e-10 NA NA NA hsa-miR-194-5p NTRK3 1.8992998339217 3.76507853301977e-10 -5.17034960965042 5.23662623079398e-21 mirMAP -0.357494409386878 7.16332837998809e-05 NA NA NA hsa-miR-140-5p NUCKS1 0.844753502512594 3.73722278438606e-05 -0.202495776728364 0.103316884003021 MirTarget;miRanda;miRNATAP -0.112544879306303 0.000111024900359395 NA NA NA hsa-miR-34a-5p NUCKS1 1.9016323452565 1.43092834643601e-14 -0.202495776728364 0.103316884003021 miRNAWalker2_validate -0.129237291176526 2.61972308129445e-08 NA NA NA hsa-miR-152-3p NUDT12 -0.0480232621705712 0.844347735441565 -0.566088538786836 0.0623665024957499 MirTarget -0.163446363726349 0.00693590867288752 NA NA NA hsa-miR-34a-5p NUMBL 1.9016323452565 1.43092834643601e-14 -0.572631697203964 0.00314600902770347 MirTarget;miRNATAP -0.230953869887576 1.93509438115372e-10 NA NA NA hsa-miR-140-5p OGDH 0.844753502512594 3.73722278438606e-05 -0.460738161297523 0.000142615836399819 miRanda -0.109974596340452 0.000118292750439183 NA NA NA hsa-miR-34a-5p OLFML1 1.9016323452565 1.43092834643601e-14 -2.63819844236782 1.29082006394553e-13 MirTarget -0.39744456650176 7.82931261640244e-09 NA NA NA hsa-miR-140-5p OPHN1 0.844753502512594 3.73722278438606e-05 -0.82871050076912 7.35176856762729e-05 miRanda -0.207578313954133 2.69529869736496e-05 NA NA NA hsa-miR-194-5p OR51E2 1.8992998339217 3.76507853301977e-10 -0.763490360358193 0.0704357511578513 MirTarget -0.338494840221873 2.21163899551036e-07 NA NA NA hsa-miR-194-5p OSBPL8 1.8992998339217 3.76507853301977e-10 -0.324025354396231 0.0431270310193481 MirTarget -0.108410934394699 1.29161696953937e-05 NA NA NA hsa-miR-194-5p OSTM1 1.8992998339217 3.76507853301977e-10 -0.771975269003669 5.13573784724769e-06 MirTarget -0.23977247633399 5.14836547175227e-21 NA NA NA hsa-miR-140-5p OXGR1 0.844753502512594 3.73722278438606e-05 -0.914809219870122 0.138254620647053 miRanda -0.360208804227457 0.0136769506356888 NA NA NA hsa-miR-140-5p OXR1 0.844753502512594 3.73722278438606e-05 -0.15110066836649 0.430478763521071 miRanda -0.164127460545053 0.000268073322517095 NA NA NA hsa-miR-34a-5p P2RY14 1.9016323452565 1.43092834643601e-14 -3.10430945553395 4.16925369709357e-16 MirTarget -0.507122556048104 5.81652122511074e-12 NA NA NA hsa-miR-34a-5p PAFAH1B2 1.9016323452565 1.43092834643601e-14 -0.0796507734002518 0.73025873683242 miRNATAP -0.163073868660292 0.00019070504272219 NA NA NA hsa-miR-140-5p PAM 0.844753502512594 3.73722278438606e-05 -1.35766444679164 1.04680437362722e-07 miRanda -0.180935585088057 0.00311084093042389 NA NA NA hsa-miR-140-5p PARK2 0.844753502512594 3.73722278438606e-05 -2.98125538061649 5.34110722830798e-14 miRanda -0.437820511288685 5.05827638515387e-06 NA NA NA hsa-miR-140-5p PARVA 0.844753502512594 3.73722278438606e-05 -1.3151470175641 1.21296874953013e-12 miRanda -0.158114970308394 0.000417569900371998 NA NA NA hsa-miR-194-5p PARVA 1.8992998339217 3.76507853301977e-10 -1.3151470175641 1.21296874953013e-12 MirTarget -0.274335256828451 3.01667209462243e-22 NA NA NA hsa-miR-34a-5p PAX5 1.9016323452565 1.43092834643601e-14 -1.22891527233864 0.0475460185287537 mirMAP -0.520882375191672 9.09442565723312e-06 NA NA NA hsa-miR-140-5p PBRM1 0.844753502512594 3.73722278438606e-05 -0.397460214092907 0.00860947905394799 miRanda -0.12898702231652 0.000294743766518465 NA NA NA hsa-miR-152-3p PBXIP1 -0.0480232621705712 0.844347735441565 -1.20374285789097 2.18223944628789e-11 MirTarget -0.11093637646242 0.00244908497888886 NA NA NA hsa-miR-140-5p PCDH7 0.844753502512594 3.73722278438606e-05 -2.71623109893059 1.19972538710733e-06 PITA;miRanda -0.431238950987053 0.0012626985192646 NA NA NA hsa-miR-34a-5p PDE4B 1.9016323452565 1.43092834643601e-14 -2.61427639301444 2.71471237993639e-11 MirTarget -0.506999362009682 1.27276496619996e-11 NA NA NA hsa-miR-34a-5p PDGFRA 1.9016323452565 1.43092834643601e-14 -2.37640583073564 1.39737819859365e-09 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.295453243484317 9.87541559838975e-05 22750848 Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network glioblastoma hsa-miR-34a-5p PDGFRB 1.9016323452565 1.43092834643601e-14 -1.03522303801072 0.00301738788961229 MirTarget -0.3682858109356 2.13745951637981e-08 24837198 MicroRNA 34A inhibits the growth invasion and metastasis of gastric cancer by targeting PDGFR and MET expression; In this study our aim was to identify the miRNAs that target PDGFR-α/β and to study the functions of these miRNAs miR-34a was predicted to target PDGFR and luciferase reporter assays showed that miR-34a could directly target PDGFR; Moreover the cancer-associated cell signalling pathway was studied and we found that miR-34a could inhibit Akt PKB protein kinase B phosphorylation which was restored by the overexpression of both PDGFR and MET; In conclusion miR-34a may act as a potential tumour suppressor in gastric cancer and is associated with the mechanisms of gastric cancer metastasis; miR-34a can inhibit gastric cancer tumourigenesis by targeting PDGFR and MET through the PI3K phosphoinositide 3-kinase/Akt pathway metastasis gastric cancer hsa-miR-34a-5p PDZRN3 1.9016323452565 1.43092834643601e-14 -3.50096884424761 2.32611531570638e-14 miRNATAP -0.741471723987459 1.396145566992e-17 NA NA NA hsa-miR-34a-5p PEA15 1.9016323452565 1.43092834643601e-14 -0.194185815009944 0.222952788863459 miRNAWalker2_validate;MirTarget;miRNATAP -0.102703644814614 0.000659711857432581 NA NA NA hsa-miR-34a-5p PEG10 1.9016323452565 1.43092834643601e-14 -1.94098497488928 0.00571305721030311 miRNATAP -0.70498740438012 1.04174293750708e-07 NA NA NA hsa-miR-140-5p PELI2 0.844753502512594 3.73722278438606e-05 -2.81494282257666 4.56195595087127e-14 miRanda -0.239348498438302 0.00861932318118468 NA NA NA hsa-miR-194-5p PER3 1.8992998339217 3.76507853301977e-10 -1.84077644313895 1.92358045112923e-09 miRNATAP -0.219450271261913 6.17679729028554e-06 NA NA NA hsa-miR-34a-5p PFKM 1.9016323452565 1.43092834643601e-14 -0.840384359428003 7.29274116373987e-06 MirTarget -0.1639877216747 4.3308316592925e-06 NA NA NA hsa-miR-34a-5p PGM1 1.9016323452565 1.43092834643601e-14 -0.551661007062109 0.0288946564086057 MirTarget;miRNATAP -0.289415216528427 9.09283245090733e-10 NA NA NA hsa-miR-34a-5p PHF19 1.9016323452565 1.43092834643601e-14 -0.569884194868888 0.0249085385065336 miRNAWalker2_validate;miRNATAP -0.366294350697072 5.86362106799447e-15 NA NA NA hsa-miR-194-5p PHLDA1 1.8992998339217 3.76507853301977e-10 -1.17554130370136 0.000663732296574257 MirTarget -0.17836420265729 0.00100365996701273 NA NA NA hsa-miR-140-5p PHLDB2 0.844753502512594 3.73722278438606e-05 -1.17405455938222 0.000219138745426489 miRanda -0.317561146524835 2.37278689429069e-05 NA NA NA hsa-miR-34a-5p PHYHIP 1.9016323452565 1.43092834643601e-14 -3.99834802867978 1.29887445710253e-14 mirMAP -0.609534862577939 1.26961483915618e-09 NA NA NA hsa-miR-34a-5p PID1 1.9016323452565 1.43092834643601e-14 -3.77845389090464 1.61614679973113e-19 miRNATAP -0.512529729993115 3.74953552570536e-10 NA NA NA hsa-miR-152-3p PIK3IP1 -0.0480232621705712 0.844347735441565 0.0421529967544005 0.870744901503072 MirTarget -0.174888875240708 0.000664126036374194 NA NA NA hsa-miR-194-5p PIP4K2A 1.8992998339217 3.76507853301977e-10 -0.910805543770034 1.94691784002652e-06 MirTarget -0.220982567686504 5.64087394087295e-14 NA NA NA hsa-miR-194-5p PITPNM2 1.8992998339217 3.76507853301977e-10 -1.16586139735313 4.1066653739082e-07 MirTarget;miRNATAP -0.288085776471006 2.98294197019556e-16 NA NA NA hsa-miR-194-5p PJA2 1.8992998339217 3.76507853301977e-10 -1.61272313300942 2.46231583136452e-21 MirTarget -0.239104452840817 4.40211913699553e-19 NA NA NA hsa-miR-194-5p PKD2 1.8992998339217 3.76507853301977e-10 -1.0649370854678 4.24438450658801e-08 miRNATAP -0.18066656695027 2.6444801700281e-09 NA NA NA hsa-miR-140-5p PKIA 0.844753502512594 3.73722278438606e-05 -0.239931947493617 0.571206859758051 miRanda -0.238607895902943 0.0172352601766783 NA NA NA hsa-miR-140-5p PLA2G12A 0.844753502512594 3.73722278438606e-05 -0.226923565397224 0.110320132886187 miRanda -0.14801862288608 8.44927388616416e-06 NA NA NA hsa-miR-34a-5p PLCB1 1.9016323452565 1.43092834643601e-14 -1.22654831568585 1.86169905806194e-05 miRNATAP -0.120203100488648 0.0292103601487345 NA NA NA hsa-miR-140-5p PLEKHA5 0.844753502512594 3.73722278438606e-05 -0.522950031208135 0.00632913279910938 miRanda -0.211181662222509 2.63477444320053e-06 NA NA NA hsa-miR-140-5p PLEKHG3 0.844753502512594 3.73722278438606e-05 -0.420475061308717 0.0570118903325053 PITA;miRanda;miRNATAP -0.342569638095393 1.99068665848865e-11 NA NA NA hsa-miR-34a-5p PLEKHM3 1.9016323452565 1.43092834643601e-14 -0.67250523933801 7.96919433369335e-05 MirTarget -0.138835306502652 1.84380277662518e-05 NA NA NA hsa-miR-34a-5p PLN 1.9016323452565 1.43092834643601e-14 -4.76371410369812 1.48137764300282e-11 MirTarget -1.19789670412661 1.11338611922565e-19 NA NA NA hsa-miR-194-5p PLXDC1 1.8992998339217 3.76507853301977e-10 0.00175712757885371 0.994886591921339 mirMAP -0.217069941683494 2.96797803073178e-07 NA NA NA hsa-miR-34a-5p PLXNA4 1.9016323452565 1.43092834643601e-14 -2.25456361904941 4.96438419774251e-05 mirMAP -0.687748520191177 4.62013158979983e-11 NA NA NA hsa-miR-152-3p PNPLA6 -0.0480232621705712 0.844347735441565 0.178774689409943 0.166147490371253 MirTarget -0.126826013907292 5.51748614444397e-07 NA NA NA hsa-miR-140-5p POLK 0.844753502512594 3.73722278438606e-05 -0.699537029301523 4.84168172122471e-06 miRanda -0.144070357937818 7.17796712687116e-05 NA NA NA hsa-miR-34a-5p POLR1A 1.9016323452565 1.43092834643601e-14 0.288169928524328 0.0751341579451263 mirMAP -0.1211875232629 7.50680130973204e-05 NA NA NA hsa-miR-140-5p POU2F1 0.844753502512594 3.73722278438606e-05 -0.0922454590182942 0.733636001316083 miRanda -0.220833416611431 0.000538020328399797 NA NA NA hsa-miR-34a-5p POU6F1 1.9016323452565 1.43092834643601e-14 -1.5750422312555 5.44817028015342e-10 MirTarget -0.326117158355093 1.35185511504135e-11 NA NA NA hsa-miR-34a-5p PPAN-P2RY11 1.9016323452565 1.43092834643601e-14 -3.29277646334275 0.000143460292404528 mirMAP -0.472624522786711 0.00442735444460448 NA NA NA hsa-miR-140-5p PPARGC1A 0.844753502512594 3.73722278438606e-05 -4.12246484079635 1.21340396096287e-10 PITA;miRanda -0.579028016104012 0.000176440132098482 NA NA NA hsa-miR-194-5p PPARGC1A 1.8992998339217 3.76507853301977e-10 -4.12246484079635 1.21340396096287e-10 miRNATAP -0.545561896706037 7.18146857687644e-08 NA NA NA hsa-miR-194-5p PPFIBP1 1.8992998339217 3.76507853301977e-10 -0.621062569088301 0.00342767338822481 MirTarget -0.210850109750664 1.02571614591424e-10 NA NA NA hsa-miR-140-5p PPL 0.844753502512594 3.73722278438606e-05 -0.331414112112754 0.352500623873735 miRanda -0.298568963559112 0.000375690435392231 NA NA NA hsa-miR-152-3p PPM1L -0.0480232621705712 0.844347735441565 -1.99556725638808 1.6810049265056e-09 MirTarget -0.15680241320841 0.0199398883181206 NA NA NA hsa-miR-140-5p PPP1CB 0.844753502512594 3.73722278438606e-05 -0.820942153588652 7.14440139700139e-11 miRanda -0.16641705160901 2.69404590531662e-08 NA NA NA hsa-miR-140-5p PPP1R12A 0.844753502512594 3.73722278438606e-05 -1.33746384858456 3.3695937531748e-17 MirTarget;PITA;miRanda -0.250049890170417 5.42355707121047e-11 NA NA NA hsa-miR-194-5p PPP1R12B 1.8992998339217 3.76507853301977e-10 -3.46376452255787 1.1364412732345e-26 mirMAP -0.407311805742723 7.97265840492628e-15 NA NA NA hsa-miR-34a-5p PPP1R16B 1.9016323452565 1.43092834643601e-14 -1.51043585925807 2.23466511532997e-06 MirTarget;miRNATAP -0.254825654355549 3.06024841308157e-05 NA NA NA hsa-miR-152-3p PPP1R9A -0.0480232621705712 0.844347735441565 -1.35308516500738 0.0293030476079856 MirTarget -0.746009955287031 8.89716897641152e-10 NA NA NA hsa-miR-194-5p PPP2R2C 1.8992998339217 3.76507853301977e-10 -0.795459846555288 0.266159255773917 miRNATAP -0.360529551006111 0.00125231259350066 NA NA NA hsa-miR-140-5p PPP2R3A 0.844753502512594 3.73722278438606e-05 -0.635587926025165 0.0133804555089022 PITA;miRanda;miRNATAP -0.162907187902368 0.00743582059722901 NA NA NA hsa-miR-34a-5p PPP2R3A 1.9016323452565 1.43092834643601e-14 -0.635587926025165 0.0133804555089022 MirTarget;miRNATAP -0.336602423463064 1.88624747596278e-12 NA NA NA hsa-miR-34a-5p PPP2R5A 1.9016323452565 1.43092834643601e-14 -0.903448375131664 8.39328972558812e-12 MirTarget;miRNATAP -0.101688531317395 7.12383430257492e-05 NA NA NA hsa-miR-194-5p PPP3CA 1.8992998339217 3.76507853301977e-10 -0.281979431665802 0.0843014975757299 MirTarget -0.17070662815415 7.35898582017249e-12 NA NA NA hsa-miR-194-5p PRICKLE2 1.8992998339217 3.76507853301977e-10 -2.50492561876767 7.67759900282699e-16 miRNATAP -0.332545564558026 1.55955134652075e-11 NA NA NA hsa-miR-34a-5p PRKAA2 1.9016323452565 1.43092834643601e-14 -3.1651157275578 4.06046613880045e-09 miRNATAP -0.697992393841294 7.93258270698692e-12 NA NA NA hsa-miR-34a-5p PRKACB 1.9016323452565 1.43092834643601e-14 -1.11910356116881 7.24897707751757e-07 miRNATAP -0.238915288481547 2.59419071561778e-08 NA NA NA hsa-miR-140-5p PRKAR2A 0.844753502512594 3.73722278438606e-05 -0.958058230501873 0.00166358416501506 miRanda -0.197853314212427 0.00623596481680405 NA NA NA hsa-miR-194-5p PRKCA 1.8992998339217 3.76507853301977e-10 -1.04253532292201 0.000330447904822586 mirMAP -0.109824345513618 0.0163784009426493 NA NA NA hsa-miR-194-5p PRKCB 1.8992998339217 3.76507853301977e-10 -3.26032077132529 1.38524824909011e-12 miRNATAP -0.485081827287577 2.16525492854143e-11 NA NA NA hsa-miR-152-3p PRKCZ -0.0480232621705712 0.844347735441565 1.78785737460806 6.93304821938799e-13 MirTarget -0.189660072380916 0.00018972316398586 NA NA NA hsa-miR-34a-5p PRKD1 1.9016323452565 1.43092834643601e-14 -1.53164811371414 4.119038025094e-05 miRNATAP -0.269413114918258 0.000161989735484372 26895471 A novel miR 34a target protein kinase D1 stimulates cancer stemness and drug resistance through GSK3/β catenin signaling in breast cancer; Additionally we discovered that PRKD1 expression was negatively regulated by miR-34a binding to the PRKD1 3'-UTR; We also found that reduction of PRKD1 by ectopic miR-34a expression or PRKD1 siRNA treatment resulted in suppressed self-renewal ability in breast cancer stem cells; These results provide evidence that regulation of PRKD1 a novel miR-34a target contributes to overcoming cancer stemness and drug resistance in human breast cancer drug resistance breast cancer hsa-miR-34a-5p PRKG1 1.9016323452565 1.43092834643601e-14 -3.08984703833363 4.55204333556294e-10 miRNATAP -0.920104832100479 6.91009801092045e-24 NA NA NA hsa-miR-34a-5p PROX1 1.9016323452565 1.43092834643601e-14 -2.49034953093375 1.14921276053561e-06 miRNATAP -0.350714162316814 0.000365803849255272 NA NA NA hsa-miR-140-5p PRPF8 0.844753502512594 3.73722278438606e-05 -0.333130079703617 0.00670894006002864 miRNAWalker2_validate -0.116709600440643 5.18080770420168e-05 NA NA NA hsa-miR-152-3p PRR15 -0.0480232621705712 0.844347735441565 1.2312635306542 0.0404717354603598 MirTarget -0.789817081985305 1.62951536383063e-11 NA NA NA hsa-miR-140-5p PRUNE2 0.844753502512594 3.73722278438606e-05 -4.80598803189319 1.66841624992026e-13 miRanda -0.371254516696891 0.0196545095832886 NA NA NA hsa-miR-34a-5p PSKH1 1.9016323452565 1.43092834643601e-14 -0.324586105655697 0.0317241984209649 mirMAP -0.114449084841355 6.16761512464708e-05 NA NA NA hsa-miR-34a-5p PTMS 1.9016323452565 1.43092834643601e-14 -0.205165066542105 0.389294656941897 miRNAWalker2_validate -0.199647320290161 8.95375767520199e-06 NA NA NA hsa-miR-194-5p PTPN12 1.8992998339217 3.76507853301977e-10 0.0767969869639664 0.640179277832713 miRNAWalker2_validate;miRTarBase -0.121254747731622 1.77062116006654e-06 27486333 Meanwhile bioinformatics tools were used to identify protein tyrosine phosphatase nonreceptor type 12 PTPN12 as a potential target of miR-194; The luciferase assay showed that miR-194 directly binds to the 3'-untranslated region of PTPN12; Western blot analysis and quantitative real-time polymerase chain reaction assay revealed that PTPN12 expression was negatively associated with miR-194 expression in both ovarian cancer tissues and cells; Thus we conclude that miR-194 targets PTPN12 and functions as an oncogene in ovarian cancer cells ovarian cancer hsa-miR-194-5p PTPRD 1.8992998339217 3.76507853301977e-10 -3.62979486144354 1.88740064210481e-09 miRNATAP -0.570268674282906 1.84449664599355e-09 NA NA NA hsa-miR-140-5p PTPRF 0.844753502512594 3.73722278438606e-05 0.582105678742497 0.00426465033783737 miRanda -0.162079385874795 0.00076116190025168 NA NA NA hsa-miR-34a-5p PYGB 1.9016323452565 1.43092834643601e-14 -1.1864973505952 3.07666105152014e-08 miRNAWalker2_validate -0.304052172852647 4.13963843774103e-14 NA NA NA hsa-miR-34a-5p RAB11FIP2 1.9016323452565 1.43092834643601e-14 -0.863768952812762 1.29857569721329e-05 MirTarget -0.120248829639454 0.00153770620679209 NA NA NA hsa-miR-140-5p RAB40B 0.844753502512594 3.73722278438606e-05 -0.525286834186003 0.0068896562299635 mirMAP -0.157931687984019 0.000580418113929116 NA NA NA hsa-miR-140-5p RABGAP1 0.844753502512594 3.73722278438606e-05 -0.773246435624024 3.15867332544188e-09 miRanda -0.225033810102322 1.53330534921654e-13 NA NA NA hsa-miR-140-5p RANBP3L 0.844753502512594 3.73722278438606e-05 -4.74365390346112 1.87665808240236e-14 miRanda -0.831071257404542 2.61315813018145e-08 NA NA NA hsa-miR-34a-5p RAP2A 1.9016323452565 1.43092834643601e-14 0.136362688904414 0.374073231500174 miRNAWalker2_validate -0.187663735963077 4.39932624437351e-11 NA NA NA hsa-miR-140-5p RAPGEF6 0.844753502512594 3.73722278438606e-05 -0.73066954697137 0.0274012483576538 miRanda -0.16037221980175 0.041269297919637 NA NA NA hsa-miR-140-5p RAPH1 0.844753502512594 3.73722278438606e-05 -0.367964714644428 0.0511328736054865 miRanda -0.111564586610932 0.0123627082716093 NA NA NA hsa-miR-34a-5p RARB 1.9016323452565 1.43092834643601e-14 -1.77858429602091 2.28807354868447e-06 miRNATAP -0.37182010349897 2.11935735449156e-07 NA NA NA hsa-miR-34a-5p RASGRP4 1.9016323452565 1.43092834643601e-14 -1.81932059503105 2.30066832429026e-06 MirTarget -0.421860932834008 7.68217450355339e-09 NA NA NA hsa-miR-34a-5p RASL12 1.9016323452565 1.43092834643601e-14 -3.19139275672019 6.99652952081998e-18 MirTarget -0.632923398487444 2.6422348682003e-19 NA NA NA hsa-miR-140-5p RBL2 0.844753502512594 3.73722278438606e-05 -0.598910927791217 0.000318998334086003 miRanda -0.11867323020571 0.00262978059184829 NA NA NA hsa-miR-194-5p RBMS2 1.8992998339217 3.76507853301977e-10 -0.473519179174953 0.00699528873663777 mirMAP -0.159464706055361 3.76885019947728e-09 NA NA NA hsa-miR-140-5p RCOR3 0.844753502512594 3.73722278438606e-05 -0.280917358332048 0.056547541206684 miRanda -0.148218415344966 1.75348661502802e-05 NA NA NA hsa-miR-34a-5p REEP3 1.9016323452565 1.43092834643601e-14 -0.227591837388122 0.197361726362941 miRNAWalker2_validate -0.109316855396802 0.00108548189961392 NA NA NA hsa-miR-34a-5p RELN 1.9016323452565 1.43092834643601e-14 -4.70097153618157 2.41994737445055e-14 miRNATAP -0.794629260378451 2.12226011368403e-11 NA NA NA hsa-miR-34a-5p RET 1.9016323452565 1.43092834643601e-14 -0.845706703693476 0.0349656102167993 MirTarget -0.280340222615168 0.000232922767956132 NA NA NA hsa-miR-140-5p REV3L 0.844753502512594 3.73722278438606e-05 -1.48371551738225 3.11717527702179e-13 miRanda -0.13266238249727 0.00738185571537509 NA NA NA hsa-miR-194-5p REV3L 1.8992998339217 3.76507853301977e-10 -1.48371551738225 3.11717527702179e-13 miRNATAP -0.202799635095558 2.82786027498087e-10 NA NA NA hsa-miR-140-5p RFX7 0.844753502512594 3.73722278438606e-05 0.140742695742857 0.380478503798894 MirTarget;miRanda -0.123668059812384 0.00104636155673421 NA NA NA hsa-miR-140-5p RGMB 0.844753502512594 3.73722278438606e-05 -0.652881684524727 1.24724355373277e-05 PITA;miRanda;miRNATAP -0.159866089287518 5.90423819606725e-06 NA NA NA hsa-miR-34a-5p RGP1 1.9016323452565 1.43092834643601e-14 -0.559845500700471 0.0212137137112516 mirMAP -0.26723797785906 4.49661861767212e-09 NA NA NA hsa-miR-140-5p RHOBTB3 0.844753502512594 3.73722278438606e-05 -0.711743990805872 0.0332323903973153 miRanda -0.158620834106189 0.0454450398751947 NA NA NA hsa-miR-34a-5p RHOBTB3 1.9016323452565 1.43092834643601e-14 -0.711743990805872 0.0332323903973153 MirTarget -0.148931351442163 0.0195413533468724 NA NA NA hsa-miR-152-3p RIBC1 -0.0480232621705712 0.844347735441565 0.494373133678538 0.0403425512737954 MirTarget -0.165478275008142 0.000553963755181768 NA NA NA hsa-miR-140-5p RIC8B 0.844753502512594 3.73722278438606e-05 -0.290396682325896 0.0149743185971823 PITA;miRanda -0.114023601261447 4.57274674106614e-05 NA NA NA hsa-miR-34a-5p RIMS3 1.9016323452565 1.43092834643601e-14 -1.42027619315578 3.00440701262036e-05 MirTarget;miRNATAP -0.440423795767199 5.22773176428325e-12 NA NA NA hsa-miR-34a-5p RIMS4 1.9016323452565 1.43092834643601e-14 -1.38584949700296 0.0181417434692426 miRNATAP -0.244232012558525 0.0293470154550189 NA NA NA hsa-miR-140-5p RIOK3 0.844753502512594 3.73722278438606e-05 -0.184431362692416 0.253606817023259 miRanda -0.16053175542903 2.20364769986782e-05 NA NA NA hsa-miR-194-5p RNF152 1.8992998339217 3.76507853301977e-10 -1.36116631616424 9.76195732579829e-06 mirMAP -0.195358183630014 5.40888401271408e-05 NA NA NA hsa-miR-140-5p RNF169 0.844753502512594 3.73722278438606e-05 -0.344671803308278 0.111344284249056 miRanda -0.160978447932406 0.00161499729556113 NA NA NA hsa-miR-34a-5p RNF216 1.9016323452565 1.43092834643601e-14 -0.284209271050796 0.0177325861546712 MirTarget;mirMAP -0.146251468103723 5.05250661056923e-11 NA NA NA hsa-miR-152-3p ROGDI -0.0480232621705712 0.844347735441565 -0.0711859496758835 0.661821773201265 MirTarget -0.15581767636614 1.10580027293625e-06 NA NA NA hsa-miR-34a-5p RORA 1.9016323452565 1.43092834643601e-14 -1.82057461685128 1.16708465709096e-09 miRNATAP -0.301913889548582 1.45777777264069e-07 NA NA NA hsa-miR-34a-5p RPGRIP1L 1.9016323452565 1.43092834643601e-14 0.460572263954295 0.011911794887315 miRNATAP -0.124872919765448 0.000328233396991803 NA NA NA hsa-miR-34a-5p RRAGC 1.9016323452565 1.43092834643601e-14 -0.343372136368613 0.147560743919937 MirTarget -0.250143791429471 1.82647959978383e-08 NA NA NA hsa-miR-34a-5p RRAGD 1.9016323452565 1.43092834643601e-14 -1.28210533175691 5.97051882858326e-05 miRNATAP -0.360340731127308 2.25475774104504e-09 NA NA NA hsa-miR-34a-5p RRAS 1.9016323452565 1.43092834643601e-14 -1.13229828735822 2.92783846173343e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.265547196825665 2.42146653994062e-07 NA NA NA hsa-miR-140-5p RSF1 0.844753502512594 3.73722278438606e-05 -0.424315702706687 0.00580455427992916 miRanda -0.147877190453015 4.34552230429246e-05 NA NA NA hsa-miR-34a-5p RSU1 1.9016323452565 1.43092834643601e-14 -0.521940994344366 0.000530310828940177 miRNAWalker2_validate -0.165894570281477 4.53653029968444e-09 NA NA NA hsa-miR-194-5p RUNX3 1.8992998339217 3.76507853301977e-10 -0.767357649844932 0.0744824809630773 miRNATAP -0.313455792167721 2.69350141176988e-06 NA NA NA hsa-miR-140-5p RYR3 0.844753502512594 3.73722278438606e-05 -3.60788187208576 2.74393851528753e-29 miRanda -0.268367641213707 0.000973015366666093 NA NA NA hsa-miR-34a-5p S1PR3 1.9016323452565 1.43092834643601e-14 -1.26632625143086 0.000598689169272835 MirTarget -0.229301466797164 0.00114333101402024 NA NA NA hsa-miR-34a-5p SAA1 1.9016323452565 1.43092834643601e-14 0.580367147926712 0.500990586635041 miRNAWalker2_validate -0.641422562877924 8.58051452440863e-05 NA NA NA hsa-miR-34a-5p SAMD14 1.9016323452565 1.43092834643601e-14 -0.753779143735079 0.0202276067098733 mirMAP -0.313030855116708 3.16093593745217e-07 NA NA NA hsa-miR-194-5p SAMD4A 1.8992998339217 3.76507853301977e-10 -2.17607774370782 7.9670339471712e-12 miRNATAP -0.457791182787352 5.93790335151826e-21 NA NA NA hsa-miR-194-5p SAMD8 1.8992998339217 3.76507853301977e-10 -0.757778066370277 0.0001176788404518 MirTarget -0.123565421198991 6.06826288927649e-05 NA NA NA hsa-miR-34a-5p SATB1 1.9016323452565 1.43092834643601e-14 -1.41790516306492 3.44896934071801e-06 MirTarget;miRNATAP -0.129358238042746 0.0280230512878416 NA NA NA hsa-miR-34a-5p SATB2 1.9016323452565 1.43092834643601e-14 0.10201173814094 0.745296023043312 miRNAWalker2_validate;MirTarget;miRNATAP -0.117793414043594 0.0489086217297985 NA NA NA hsa-miR-140-5p SBDS 0.844753502512594 3.73722278438606e-05 -1.0090640264046 1.65732594610211e-15 MirTarget;PITA;miRanda;miRNATAP -0.110887569255752 0.000318029594316938 NA NA NA hsa-miR-140-5p SBF2 0.844753502512594 3.73722278438606e-05 -0.766135575243088 1.02611942343428e-05 miRanda -0.236078949365788 6.92249197703217e-09 NA NA NA hsa-miR-140-5p SCMH1 0.844753502512594 3.73722278438606e-05 -0.561073318183707 0.001514810259758 miRanda -0.17829944785846 1.86759483699738e-05 NA NA NA hsa-miR-34a-5p SCML2 1.9016323452565 1.43092834643601e-14 -0.950080740895381 0.0546941084335224 MirTarget;miRNATAP -0.56046075684538 1.44678408172072e-09 NA NA NA hsa-miR-34a-5p SCN2B 1.9016323452565 1.43092834643601e-14 -4.29366513636715 3.96960287530702e-15 MirTarget;miRNATAP -0.945153482826181 4.61845403658e-20 NA NA NA hsa-miR-34a-5p SEPT7 1.9016323452565 1.43092834643601e-14 -0.502994288413354 6.27947005227609e-06 miRNAWalker2_validate -0.175711270561873 9.57221248839149e-18 NA NA NA hsa-miR-34a-5p SERPINB1 1.9016323452565 1.43092834643601e-14 -0.430266614782949 0.22057926715014 miRNAWalker2_validate -0.255236455357005 0.000125132058089275 NA NA NA hsa-miR-140-5p SETD2 0.844753502512594 3.73722278438606e-05 -0.183491510728843 0.132486222465729 miRanda -0.137858524438801 1.2229622030764e-06 NA NA NA hsa-miR-34a-5p SETD3 1.9016323452565 1.43092834643601e-14 -0.540709000480151 6.78781937310879e-07 miRNAWalker2_validate -0.105521816340478 3.11891948841458e-07 NA NA NA hsa-miR-140-5p SGCB 0.844753502512594 3.73722278438606e-05 -1.44760592804974 4.88730706418823e-10 miRanda -0.195223532966665 0.000488045063249711 NA NA NA hsa-miR-140-5p SGCD 0.844753502512594 3.73722278438606e-05 -3.54960120603853 1.88168939363754e-09 PITA -0.28390403148796 0.0468721684594978 NA NA NA hsa-miR-34a-5p SGPP1 1.9016323452565 1.43092834643601e-14 -0.148910476883497 0.606055761679441 miRNAWalker2_validate;MirTarget;miRNATAP -0.216186309327403 7.537410867789e-05 NA NA NA hsa-miR-140-5p SH3D19 0.844753502512594 3.73722278438606e-05 -1.30425154826739 1.64955066860169e-11 PITA;miRanda -0.383012109736222 2.20272193181983e-17 NA NA NA hsa-miR-140-5p SH3PXD2A 0.844753502512594 3.73722278438606e-05 -0.987155493438988 1.02406192375196e-05 mirMAP -0.21221919698868 6.45193710845453e-05 NA NA NA hsa-miR-194-5p SH3PXD2A 1.8992998339217 3.76507853301977e-10 -0.987155493438988 1.02406192375196e-05 mirMAP -0.297069549340301 2.03884361138366e-18 NA NA NA hsa-miR-34a-5p SH3PXD2A 1.9016323452565 1.43092834643601e-14 -0.987155493438988 1.02406192375196e-05 MirTarget -0.141178709095079 0.000996098283931466 NA NA NA hsa-miR-140-5p SHROOM2 0.844753502512594 3.73722278438606e-05 1.0231503754521 0.0018764752696863 miRanda -0.179512492419723 0.0217615956865792 NA NA NA hsa-miR-140-5p SHROOM3 0.844753502512594 3.73722278438606e-05 -1.26167822754868 0.000636872985591942 MirTarget;PITA;miRanda;miRNATAP -0.198318104790648 0.0241413681190294 NA NA NA hsa-miR-34a-5p SIK2 1.9016323452565 1.43092834643601e-14 -0.895905910195029 1.03810013473188e-10 mirMAP -0.172243703359764 6.36234892738211e-11 NA NA NA hsa-miR-140-5p SIPA1L2 0.844753502512594 3.73722278438606e-05 -0.971413252489691 0.000894981637447019 miRanda -0.146093883569637 0.0358231357070034 NA NA NA hsa-miR-34a-5p SIRT1 1.9016323452565 1.43092834643601e-14 -1.03742756823581 3.19867751848926e-11 miRNAWalker2_validate;miRTarBase;miRNATAP -0.117141124440484 0.000108824317675673 25982144;21067862;20687223;22623155;23954321;26722316;25826085;27126903;26518892;18834855 5 Aminolevulinic acid mediated sonodynamic therapy induces anti tumor effects in malignant melanoma via p53 miR 34a Sirt1 axis; Therefore the p53 miR-34a and SIRT1 constituted a positive feedback loop;Sirt1 which is one of the target genes for miR-34a and related to drug-resistance was strikingly up-regulated in the 5-FU-resistant cells; The ectopic expression of miR-34a in the 5-FU-resistant cells inhibited growth as in the parental cells and attenuated the resistance to 5-FU through the down-regulation of Sirt1 and E2F3; These findings suggest that miR-34a targeting the Sirt1 and E2F3 genes could negatively regulate at least in part the resistance to 5-FU in human colorectal cancer DLD-1 cells;We aimed to elucidate the molecular mechanisms underlying paclitaxel resistance of hormone-refractory prostate cancer with a special focus on the roles of miR-34a and SIRT1; MiR-34a over-expression and SIRT1 knockdown attenuated paclitaxel resistance of PC3PR cells; Thus in PC3PR cells reduced expression of miR-34a confers paclitaxel resistance via up-regulating SIRT1 and Bcl2 expression; MiR-34a and its downstream targets SIRT1 and Bcl2 play important roles in the development of paclitaxel resistance all of which can be useful biomarkers and promising therapeutic targets for the drug resistance in hormone-refractory prostate cancer;MiR 34a inhibits proliferation and migration of breast cancer through down regulation of Bcl 2 and SIRT1; In this study we aimed to determine the effect of miR-34a on the growth of breast cancer and to investigate whether its effect is achieved by targeting Bcl-2 and SIRT1; Bcl-2 and SIRT1 as the targets of miR-34a were found to be in reverse correlation with ectopic expression of miR-34a;Interestingly RES increased the intracellular expression level of miR-34a which down-regulated the target gene E2F3 and its downstream Sirt1 resulting in growth inhibition;miR 34a inhibits cell proliferation in prostate cancer by downregulation of SIRT1 expression; The role of miR-34a in regulating sirtuin 1 SIRT1 in prostate cancer remains unclear; The objective of the present study was to investigate the biological function and molecular mechanisms of miR-34a regulation of SIRT1 in human prostate cancer samples and the human prostate cancer cell line PC-3; Fresh prostate tissues were obtained from patients and the miR-34a expression in prostate cancer tissues was measured using reverse transcription-quantitative polymerase chain reaction RT-qPCR qPCR and western blotting were performed to assess the effects of miR-34a overexpression on SIRT1 regulation in PC-3 cells and the cell growth was assessed by Cell Counting Kit-8 CCK-8; SIRT1 expression levels in PC-3 cells with over-expression of miR-34a were significantly reduced compared with those in the negative control P<0.05; In conclusion miR-34a inhibits the human prostate cancer cell proliferation in part through the downregulation of SIRT1 expression;Dysregulation of the miR 34a SIRT1 axis inhibits breast cancer stemness; Sirtuin-1 SIRT1 is a direct target of miR-34a; Here we found low levels of miR-34a and high levels of SIRT1 in CD44+/CD24- breast cancer stem cells BCSCs; MiR-34a overexpression and knockdown of SIRT1 decreased proportion of BSCSs and mammosphere formation; In nude mice xenografts stable expression of miR-34a and silencing of SIRT1 reduced tumor burden; Taken together our results demonstrated that miR-34a inhibits proliferative potential of BCSCs in vitro and in vivo at least partially by downregulating SIRT1;In addition the present micellar system facilitated the escape of miR-34a from the endosome and release of DOX into the cell nucleus leading to the downregulation of silent information regulator 1 SIRT1 expression and inhibition of DU145 and PC3 androgen-independent prostate cancer cell proliferation;For example overexpressing miR-34a a master regulator of tumor suppression attenuates chemoresistance to 5-FU by downregulating silent information regulator 1 SIRT1 and E2F3;In PC3 cell ectopic expression of miR-34a decreased the SIRT1 mRNA and protein levels as well as protein levels of known direct target genes; Reporter assays revealed that miR-34a-induced SIRT1 inhibition occurred at the transcriptional but not post-transcriptional level despite the presence of a potential miR-34a binding site within its 3'-UTR malignant trasformation;drug resistance;drug resistance;;;;;;drug resistance; melanoma;colon cancer;prostate cancer;breast cancer;colon cancer;prostate cancer;breast cancer;prostate cancer;colorectal cancer;prostate cancer hsa-miR-152-3p SIRT7 -0.0480232621705712 0.844347735441565 1.17798766758541 2.00888355494363e-13 MirTarget -0.181531005632769 2.03959832438661e-08 NA NA NA hsa-miR-194-5p SLC12A6 1.8992998339217 3.76507853301977e-10 -0.225529358014598 0.321295027857378 MirTarget -0.107065053256625 0.00255009217907118 NA NA NA hsa-miR-34a-5p SLC16A2 1.9016323452565 1.43092834643601e-14 -1.53927355158781 4.3817377775803e-06 mirMAP -0.556012879925461 2.31984858477906e-19 NA NA NA hsa-miR-140-5p SLC22A17 0.844753502512594 3.73722278438606e-05 -1.29730131042332 1.73061136534582e-05 miRanda -0.283554790236262 7.65293371318274e-05 NA NA NA hsa-miR-140-5p SLC24A1 0.844753502512594 3.73722278438606e-05 -0.208567913513509 0.212628505134594 miRanda -0.137707593197819 0.000463984250860077 NA NA NA hsa-miR-140-5p SLC25A23 0.844753502512594 3.73722278438606e-05 -1.90764593095584 9.73349374206712e-11 miRanda -0.398446838756427 1.43557887326542e-08 NA NA NA hsa-miR-140-5p SLC25A4 0.844753502512594 3.73722278438606e-05 -1.33644619640139 4.13992398920302e-12 miRanda -0.242532520839426 1.51609559340747e-07 NA NA NA hsa-miR-140-5p SLC2A1 0.844753502512594 3.73722278438606e-05 0.844343559552885 0.0169954869776823 MirTarget;miRanda;miRNATAP -0.269888930806822 0.00125520291526824 NA NA NA hsa-miR-34a-5p SLC2A13 1.9016323452565 1.43092834643601e-14 -1.18256435189023 3.80131152801412e-05 miRNATAP -0.325842890406393 1.80520761231188e-09 NA NA NA hsa-miR-34a-5p SLC2A14 1.9016323452565 1.43092834643601e-14 -2.04597485691248 7.35967822773436e-07 miRNAWalker2_validate -0.365242530470944 3.82878250764088e-06 NA NA NA hsa-miR-194-5p SLC2A3 1.8992998339217 3.76507853301977e-10 -2.09454232135098 3.92772896271437e-08 miRNATAP -0.409736303311616 4.56883857897428e-12 NA NA NA hsa-miR-34a-5p SLC2A3 1.9016323452565 1.43092834643601e-14 -2.09454232135098 3.92772896271437e-08 miRNAWalker2_validate -0.335781037210638 4.47080444346655e-06 NA NA NA hsa-miR-34a-5p SLC6A16 1.9016323452565 1.43092834643601e-14 -2.20802995506184 3.2208227755399e-06 miRNAWalker2_validate -0.403679404075837 8.48916564623487e-06 NA NA NA hsa-miR-34a-5p SLC6A17 1.9016323452565 1.43092834643601e-14 0.941104200796897 0.0568131902197341 miRNATAP -0.367577643108895 8.77000802331651e-05 NA NA NA hsa-miR-34a-5p SLC7A1 1.9016323452565 1.43092834643601e-14 0.0553385590912683 0.83891351896488 mirMAP -0.232249878829794 6.0415270497118e-06 NA NA NA hsa-miR-194-5p SLC7A5 1.8992998339217 3.76507853301977e-10 0.300555838333679 0.414925029306557 MirTarget -0.174459307126528 0.00244492071000326 NA NA NA hsa-miR-34a-5p SLCO3A1 1.9016323452565 1.43092834643601e-14 -0.349114583112527 0.300053914964445 MirTarget;miRNATAP -0.195823064603045 0.00221566399106474 NA NA NA hsa-miR-140-5p SLMAP 0.844753502512594 3.73722278438606e-05 -1.93428348280594 2.36632563569771e-23 PITA;miRanda -0.379522056638625 5.79674023119429e-16 NA NA NA hsa-miR-140-5p SMAD4 0.844753502512594 3.73722278438606e-05 -0.586921155134023 3.52416916552263e-06 miRanda -0.114517150132142 0.000134319769998401 NA NA NA hsa-miR-34a-5p SMAD4 1.9016323452565 1.43092834643601e-14 -0.586921155134023 3.52416916552263e-06 miRNATAP -0.121709073519824 3.8975183335493e-07 22750848 Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network; Specifically in glioblastoma within the context of the global network promoter enrichment analysis of network edges uncovered a novel regulation of TGF-β signaling via a Smad4 transcriptomic network by miR-34a glioblastoma hsa-miR-34a-5p SMAD7 1.9016323452565 1.43092834643601e-14 -1.18986730797292 6.37278457783496e-08 MirTarget -0.136694424476981 0.00127398242742499 NA NA NA hsa-miR-140-5p SMARCC2 0.844753502512594 3.73722278438606e-05 0.108371151941655 0.364995630386278 miRanda -0.101253519851037 0.000300346872233482 NA NA NA hsa-miR-140-5p SMOC2 0.844753502512594 3.73722278438606e-05 -3.77071504008826 1.36024971965293e-14 miRanda -0.236297876238407 0.0489164414989477 NA NA NA hsa-miR-34a-5p SNAP25 1.9016323452565 1.43092834643601e-14 -1.14591384974572 0.0327342558924054 miRNATAP -0.477871557864455 2.46720878134202e-06 NA NA NA hsa-miR-152-3p SNN -0.0480232621705712 0.844347735441565 -0.434630874607479 0.026982293104271 MirTarget -0.108842617775111 0.0054150276584043 NA NA NA hsa-miR-34a-5p SNPH 1.9016323452565 1.43092834643601e-14 -0.856242399827214 0.00165958426767376 mirMAP -0.211587898799019 4.32801701671779e-05 NA NA NA hsa-miR-34a-5p SNTB2 1.9016323452565 1.43092834643601e-14 -0.441658705547666 0.00100504578260347 miRNAWalker2_validate -0.171129704303543 7.5691721860405e-12 NA NA NA hsa-miR-140-5p SNX12 0.844753502512594 3.73722278438606e-05 -0.200376025433756 0.257087274836022 MirTarget -0.125436521477861 0.00259665552973278 NA NA NA hsa-miR-34a-5p SNX12 1.9016323452565 1.43092834643601e-14 -0.200376025433756 0.257087274836022 miRNAWalker2_validate;MirTarget;miRNATAP -0.143477931409484 1.68526998883892e-05 NA NA NA hsa-miR-140-5p SNX27 0.844753502512594 3.73722278438606e-05 -0.342530168251602 0.00930198321883808 PITA;miRanda;miRNATAP -0.127013639912827 3.97175782669455e-05 NA NA NA hsa-miR-194-5p SNX29 1.8992998339217 3.76507853301977e-10 -0.637224583441126 6.77957051876116e-05 miRNATAP -0.156519013964862 2.27046436540967e-10 NA NA NA hsa-miR-34a-5p SNX29 1.9016323452565 1.43092834643601e-14 -0.637224583441126 6.77957051876116e-05 mirMAP -0.153182880006045 4.22118416813171e-07 NA NA NA hsa-miR-34a-5p SNX30 1.9016323452565 1.43092834643601e-14 0.0810480588629172 0.652515057244654 miRNATAP -0.106469048066774 0.00179658484033176 NA NA NA hsa-miR-140-5p SORL1 0.844753502512594 3.73722278438606e-05 -0.847329260991978 0.0631880459207308 miRanda -0.25092211804111 0.0202363471545508 NA NA NA hsa-miR-140-5p SORT1 0.844753502512594 3.73722278438606e-05 -0.442885894945205 0.0429425269324855 miRanda -0.169815639007647 0.00100295360470893 NA NA NA hsa-miR-140-5p SOS2 0.844753502512594 3.73722278438606e-05 -0.541773165962052 3.38343002773895e-05 miRanda -0.175305178985449 9.75022022997209e-09 NA NA NA hsa-miR-34a-5p SOX2 1.9016323452565 1.43092834643601e-14 -0.323595368728617 0.681514582034885 miRNAWalker2_validate;miRTarBase -0.418653713804836 0.00524040301276666 NA NA NA hsa-miR-194-5p SOX5 1.8992998339217 3.76507853301977e-10 -2.80899915084138 3.69546336813367e-12 miRNAWalker2_validate;miRTarBase -0.307516115346221 1.80193332263549e-06 NA NA NA hsa-miR-194-5p SOX6 1.8992998339217 3.76507853301977e-10 -2.16170894059309 7.49520430040923e-06 miRNATAP -0.157232385294712 0.039802892101918 NA NA NA hsa-miR-34a-5p SOX6 1.9016323452565 1.43092834643601e-14 -2.16170894059309 7.49520430040923e-06 miRNATAP -0.359369643789747 0.000101272748769117 NA NA NA hsa-miR-140-5p SPARCL1 0.844753502512594 3.73722278438606e-05 -3.40162664400893 2.7719294425762e-22 miRanda -0.261002188247627 0.00279172279201645 NA NA NA hsa-miR-140-5p SPATA6 0.844753502512594 3.73722278438606e-05 -1.47438232360334 2.63198136635145e-05 MirTarget -0.212579801602629 0.0111279577824887 NA NA NA hsa-miR-34a-5p SPI1 1.9016323452565 1.43092834643601e-14 -0.303903678192015 0.447316474486497 miRNAWalker2_validate -0.29884651506223 7.88009966070382e-05 NA NA NA hsa-miR-140-5p SPOCK1 0.844753502512594 3.73722278438606e-05 -0.605188458396325 0.230666218148078 MirTarget;PITA;miRanda -0.342693149712005 0.0040714048847833 NA NA NA hsa-miR-194-5p SPRED1 1.8992998339217 3.76507853301977e-10 -0.64004595524649 0.00626859347930208 miRNATAP -0.217346054726263 1.74103238686257e-09 NA NA NA hsa-miR-34a-5p SPRED1 1.9016323452565 1.43092834643601e-14 -0.64004595524649 0.00626859347930208 miRNATAP -0.255133581450969 6.6069311768714e-09 NA NA NA hsa-miR-34a-5p SPTAN1 1.9016323452565 1.43092834643601e-14 -0.510431340463778 0.00153188209696753 miRNAWalker2_validate -0.138432560381903 5.58887177696604e-06 NA NA NA hsa-miR-34a-5p SPTBN1 1.9016323452565 1.43092834643601e-14 -0.735351026844664 0.000347171300601555 miRNAWalker2_validate -0.199718395817061 2.79500301041961e-07 NA NA NA hsa-miR-194-5p SRGN 1.8992998339217 3.76507853301977e-10 -1.44128991368294 0.000246133540125372 MirTarget -0.468729692474214 5.72623713400356e-15 NA NA NA hsa-miR-194-5p SRXN1 1.8992998339217 3.76507853301977e-10 -0.0756949630207062 0.756823031502278 mirMAP -0.153326313368048 5.39322252886602e-05 NA NA NA hsa-miR-140-5p SSBP2 0.844753502512594 3.73722278438606e-05 -1.50095838408439 5.47169471767289e-08 miRanda -0.208632962181844 0.00162866424927606 NA NA NA hsa-miR-140-5p ST5 0.844753502512594 3.73722278438606e-05 -1.12234107216633 1.57219334258428e-06 MirTarget;PITA;miRanda;miRNATAP -0.224030218151731 5.59483092970279e-05 NA NA NA hsa-miR-34a-5p STAC2 1.9016323452565 1.43092834643601e-14 -0.583414225007588 0.277040384550552 miRNATAP -0.234173858268266 0.0220373398473181 NA NA NA hsa-miR-140-5p STAG1 0.844753502512594 3.73722278438606e-05 -0.245728256557948 0.202447685081763 miRanda -0.140589583336782 0.00196969431862876 NA NA NA hsa-miR-140-5p STAM2 0.844753502512594 3.73722278438606e-05 -0.459002176084125 0.000119908684750531 miRanda -0.104305895330426 0.000212445330453972 NA NA NA hsa-miR-34a-5p STAT1 1.9016323452565 1.43092834643601e-14 0.542663454678779 0.0737713250641883 miRNAWalker2_validate -0.236831607684438 3.76320893148253e-05 NA NA NA hsa-miR-34a-5p STC1 1.9016323452565 1.43092834643601e-14 -1.55340441030689 1.29077994156941e-05 miRNATAP -0.223305585033756 0.00108351478165292 NA NA NA hsa-miR-140-5p STIM1 0.844753502512594 3.73722278438606e-05 -0.728873903962043 1.9586992363805e-06 MirTarget;miRanda -0.132483078858155 0.00027531593302083 NA NA NA hsa-miR-34a-5p STK38L 1.9016323452565 1.43092834643601e-14 -0.765014874635487 4.35127290099018e-05 MirTarget -0.204620628389829 6.85173806885803e-09 NA NA NA hsa-miR-140-5p STON2 0.844753502512594 3.73722278438606e-05 0.911147071407097 0.00541134596684279 miRanda -0.230458659083795 0.00298942680834503 NA NA NA hsa-miR-140-5p STOX1 0.844753502512594 3.73722278438606e-05 -0.45573489698022 0.240941316891762 miRanda -0.186530090945378 0.0426774398486058 NA NA NA hsa-miR-140-5p STOX2 0.844753502512594 3.73722278438606e-05 -1.03419792881613 0.00367103026717332 miRanda -0.263421518298324 0.00179228386154556 NA NA NA hsa-miR-34a-5p STRAP 1.9016323452565 1.43092834643601e-14 -0.0609987087335284 0.638521952110271 miRNAWalker2_validate -0.101302148739036 3.37779250298755e-05 NA NA NA hsa-miR-140-5p STRN3 0.844753502512594 3.73722278438606e-05 -0.694246317299341 2.23666142606823e-06 MirTarget;PITA;miRanda -0.143461912636734 3.73664096263867e-05 NA NA NA hsa-miR-34a-5p STRN3 1.9016323452565 1.43092834643601e-14 -0.694246317299341 2.23666142606823e-06 MirTarget;miRNATAP -0.169613586220948 8.87394242222182e-10 NA NA NA hsa-miR-34a-5p STX17 1.9016323452565 1.43092834643601e-14 -0.343981391742685 0.00166799096480426 MirTarget -0.100423965033157 1.0636596657868e-06 NA NA NA hsa-miR-34a-5p STX1B 1.9016323452565 1.43092834643601e-14 -0.831193288425681 0.0477395804955152 mirMAP -0.376227781373039 2.09525210432239e-06 NA NA NA hsa-miR-140-5p STXBP4 0.844753502512594 3.73722278438606e-05 -0.672568570001511 0.000366466402920882 miRanda -0.202831882419979 5.09140509531539e-06 NA NA NA hsa-miR-140-5p SYDE2 0.844753502512594 3.73722278438606e-05 -1.16272249793845 0.000106405818938536 miRanda -0.396208170527511 1.8552480662503e-08 NA NA NA hsa-miR-34a-5p SYNE2 1.9016323452565 1.43092834643601e-14 -0.381691294548014 0.0787393265300737 miRNAWalker2_validate -0.243208586454659 2.11811769371397e-09 NA NA NA hsa-miR-34a-5p SYT1 1.9016323452565 1.43092834643601e-14 -0.547551993916526 0.281961898919138 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.332297285704628 0.000581145710997762 NA NA NA hsa-miR-152-3p SYT10 -0.0480232621705712 0.844347735441565 -0.277172838009389 0.638612322888544 MirTarget -0.43861326221979 0.000177992881565225 NA NA NA hsa-miR-34a-5p TAF4B 1.9016323452565 1.43092834643601e-14 -0.440551340182907 0.163919692677726 miRNATAP -0.377549070491061 1.61614730973031e-10 NA NA NA hsa-miR-140-5p TAF9B 0.844753502512594 3.73722278438606e-05 -0.526397466718249 0.000526353617354111 miRanda;miRNATAP -0.118204829020384 0.000998787468020146 NA NA NA hsa-miR-140-5p TAOK1 0.844753502512594 3.73722278438606e-05 -0.507192494879209 0.107943198436468 miRanda -0.245159751415159 0.000990905014973656 NA NA NA hsa-miR-140-5p TAX1BP3 0.844753502512594 3.73722278438606e-05 0.233574222061766 0.150466128166257 miRanda -0.108046517213203 0.00477189246973146 NA NA NA hsa-miR-34a-5p TBC1D16 1.9016323452565 1.43092834643601e-14 -0.000723386575430585 0.997052256137848 mirMAP -0.167641168981214 5.44961881921373e-06 NA NA NA hsa-miR-140-5p TBC1D8B 0.844753502512594 3.73722278438606e-05 0.116815875495747 0.594310169494837 miRanda -0.133556354029688 0.0098708757706499 NA NA NA hsa-miR-34a-5p TCF12 1.9016323452565 1.43092834643601e-14 -0.437166250390586 0.00485294102410064 MirTarget;miRNATAP -0.160477566684174 3.72213428026613e-08 NA NA NA hsa-miR-140-5p TCP11L2 0.844753502512594 3.73722278438606e-05 -0.706818942262929 0.00511598864464442 miRanda -0.174094085571862 0.00360479733052416 NA NA NA hsa-miR-140-5p TEAD1 0.844753502512594 3.73722278438606e-05 -1.49495998391161 1.96516757915294e-13 PITA;miRanda;miRNATAP -0.211631995183254 1.67532508142447e-05 NA NA NA hsa-miR-194-5p TEAD1 1.8992998339217 3.76507853301977e-10 -1.49495998391161 1.96516757915294e-13 MirTarget -0.181266401864408 1.98768389322605e-08 NA NA NA hsa-miR-140-5p TECPR2 0.844753502512594 3.73722278438606e-05 -0.716350928013042 1.36980023302723e-09 miRanda -0.20292977930386 1.9558284124645e-13 NA NA NA hsa-miR-34a-5p TES 1.9016323452565 1.43092834643601e-14 -1.08685329583047 1.15308429217781e-07 miRNAWalker2_validate -0.303863427252864 2.14973771165893e-15 NA NA NA hsa-miR-140-5p TET2 0.844753502512594 3.73722278438606e-05 -0.0355625714212948 0.838982280854655 miRanda -0.15335298932979 0.000188837541400363 NA NA NA hsa-miR-34a-5p TGM2 1.9016323452565 1.43092834643601e-14 -1.14690935857596 0.0144751654848477 miRNAWalker2_validate -0.596492455291748 9.16055361131472e-12 NA NA NA hsa-miR-140-5p THAP10 0.844753502512594 3.73722278438606e-05 -0.137873690517466 0.517983525847403 miRanda -0.127487343981358 0.0113187016101332 NA NA NA hsa-miR-140-5p THAP2 0.844753502512594 3.73722278438606e-05 -0.714248114560796 1.80795659981393e-05 miRanda -0.171436815326132 1.3516368885121e-05 NA NA NA hsa-miR-140-5p THRA 0.844753502512594 3.73722278438606e-05 -1.80486534711542 1.86472212451361e-16 mirMAP -0.205328897991389 0.000126872064178409 NA NA NA hsa-miR-140-5p THSD4 0.844753502512594 3.73722278438606e-05 -2.37339687749734 3.92006931404185e-13 miRanda -0.219507762625124 0.00582558626258998 NA NA NA hsa-miR-140-5p THSD7B 0.844753502512594 3.73722278438606e-05 -3.04311111436839 2.54136919894489e-07 miRanda -0.475247192326808 0.000771631163269323 NA NA NA hsa-miR-140-5p TJP1 0.844753502512594 3.73722278438606e-05 -0.702942121782242 1.25097615231369e-05 MirTarget;PITA;miRanda -0.175332912675564 3.96656228093942e-06 NA NA NA hsa-miR-140-5p TM7SF3 0.844753502512594 3.73722278438606e-05 0.185551681471273 0.361592058650735 miRanda -0.118056318557733 0.0139405132905963 NA NA NA hsa-miR-34a-5p TMCC3 1.9016323452565 1.43092834643601e-14 -1.35239851980287 4.93606931842352e-05 MirTarget;miRNATAP -0.3988923386118 2.02559123658569e-10 NA NA NA hsa-miR-140-5p TMEM106B 0.844753502512594 3.73722278438606e-05 -0.267302349407767 0.0771914123734547 miRanda -0.119439913190195 0.000789231561817026 NA NA NA hsa-miR-194-5p TMEM108 1.8992998339217 3.76507853301977e-10 -2.78114300571125 1.45650573276381e-06 MirTarget -0.468271694394229 2.26126880419886e-07 NA NA NA hsa-miR-194-5p TMEM200A 1.8992998339217 3.76507853301977e-10 -1.15177228193657 0.00384870143135601 MirTarget -0.461398993177835 3.15216343729988e-14 NA NA NA hsa-miR-34a-5p TMEM200B 1.9016323452565 1.43092834643601e-14 -1.42414763286868 0.00190297304643915 miRNATAP -0.410404695596541 2.35619773831901e-06 NA NA NA hsa-miR-140-5p TMEM50B 0.844753502512594 3.73722278438606e-05 -0.500952700633102 0.00102711645551271 miRanda -0.106659374191778 0.00314642351556834 NA NA NA hsa-miR-152-3p TMEM54 -0.0480232621705712 0.844347735441565 0.876713380540653 5.81418996174114e-05 MirTarget -0.196872198650463 5.75128803276758e-06 NA NA NA hsa-miR-34a-5p TMEM55A 1.9016323452565 1.43092834643601e-14 -1.20928980478551 1.66704876794806e-07 MirTarget -0.341642443217465 2.54141966441908e-15 NA NA NA hsa-miR-140-5p TMEM59 0.844753502512594 3.73722278438606e-05 -0.0589479694342181 0.633788610781044 miRanda -0.109790596710812 0.000149175515417458 NA NA NA hsa-miR-34a-5p TMEM63C 1.9016323452565 1.43092834643601e-14 0.808209141397143 0.155209732021727 mirMAP -0.27005516911793 0.0126816114622612 NA NA NA hsa-miR-140-5p TMEM67 0.844753502512594 3.73722278438606e-05 0.149118217117894 0.430399210579031 miRanda -0.108292300293733 0.0152458781865675 NA NA NA hsa-miR-34a-5p TMOD2 1.9016323452565 1.43092834643601e-14 -1.02377830752032 1.97345844232229e-05 miRNAWalker2_validate -0.323217572186162 5.85945396791463e-13 NA NA NA hsa-miR-140-5p TMX4 0.844753502512594 3.73722278438606e-05 -0.933228791579491 1.34545470463139e-07 MirTarget;miRanda -0.234665484532728 1.96868852881957e-08 NA NA NA hsa-miR-140-5p TNKS 0.844753502512594 3.73722278438606e-05 -0.338432274017598 0.0297542921065014 miRanda -0.139780947593955 0.000134227259057116 NA NA NA hsa-miR-140-5p TNNI1 0.844753502512594 3.73722278438606e-05 2.04660782545201 1.93467256331363e-07 miRanda -0.232023336038007 0.0139875554673663 NA NA NA hsa-miR-34a-5p TNPO1 1.9016323452565 1.43092834643601e-14 -0.196064925187165 0.136005283860513 miRNAWalker2_validate -0.141302014792235 8.58901974747901e-09 NA NA NA hsa-miR-140-5p TOM1L1 0.844753502512594 3.73722278438606e-05 0.690771070040168 0.00159833007999815 miRanda -0.154496282332094 0.00290001086110884 NA NA NA hsa-miR-34a-5p TP53INP2 1.9016323452565 1.43092834643601e-14 -2.21250190189587 4.52774358230457e-20 MirTarget -0.311337475321648 3.80277585826934e-11 NA NA NA hsa-miR-34a-5p TPM1 1.9016323452565 1.43092834643601e-14 -2.65530585768087 2.50185615635583e-17 miRNAWalker2_validate -0.600882326868458 1.44424511680119e-24 NA NA NA hsa-miR-34a-5p TPPP 1.9016323452565 1.43092834643601e-14 -4.06681960647858 1.27319129789239e-22 miRNAWalker2_validate;MirTarget -0.392068927494331 2.17448465996609e-06 NA NA NA hsa-miR-140-5p TRIM2 0.844753502512594 3.73722278438606e-05 -1.24600852758983 0.000109711849149996 miRanda -0.356414477665147 2.79198664617078e-06 NA NA NA hsa-miR-194-5p TRIM23 1.8992998339217 3.76507853301977e-10 -0.671091371187086 1.11849461042915e-06 MirTarget -0.134935102330469 2.56779010116305e-10 26221053 Transcripts encoding tripartite motif containing 23 TRIM23 a ubiquitin ligase involved in NF-κB activation and chromosome 21 open reading frame 91 C21ORF91 a protein of unknown function were identified as direct targets of miR-194 in HCC cells; knocking down either protein decreased the activity of a luciferase NF-κB reporter liver cancer hsa-miR-194-5p TRIP12 1.8992998339217 3.76507853301977e-10 -0.413791367148874 0.00168445227637928 MirTarget -0.108076837453524 1.1158315139041e-07 NA NA NA hsa-miR-194-5p TRPS1 1.8992998339217 3.76507853301977e-10 -2.16842073246699 1.62641545265475e-06 MirTarget;miRNATAP -0.46535310518584 3.2223289609393e-11 NA NA NA hsa-miR-140-5p TSC22D1 0.844753502512594 3.73722278438606e-05 -1.75361245196073 6.61831957327972e-18 miRanda -0.129116967241818 0.0099721734751183 NA NA NA hsa-miR-140-5p TSHZ1 0.844753502512594 3.73722278438606e-05 -1.18240418405489 8.72156338070878e-10 miRanda -0.213373353904271 3.66921998961853e-06 NA NA NA hsa-miR-34a-5p TSHZ2 1.9016323452565 1.43092834643601e-14 -2.36271880423433 2.34708957144416e-08 miRNATAP -0.407694855030008 4.94025396963828e-07 NA NA NA hsa-miR-34a-5p TSPAN11 1.9016323452565 1.43092834643601e-14 -2.3587553580542 3.63548653474133e-10 mirMAP -0.222589739531513 0.00233273214432045 NA NA NA hsa-miR-140-5p TSPAN18 0.844753502512594 3.73722278438606e-05 -2.63099439180161 1.17021451486886e-12 mirMAP -0.253807932707784 0.00479437089709303 NA NA NA hsa-miR-34a-5p TTBK1 1.9016323452565 1.43092834643601e-14 0.592902015109751 0.108572420184107 mirMAP -0.167312139247633 0.0175099183374356 NA NA NA hsa-miR-152-3p TXNIP -0.0480232621705712 0.844347735441565 -1.19206229218288 1.53140877295634e-05 MirTarget -0.247214686089264 6.97989928659633e-06 NA NA NA hsa-miR-34a-5p TXNRD1 1.9016323452565 1.43092834643601e-14 -1.12063019657297 0.000151225388551436 miRNAWalker2_validate -0.45525586967837 8.2401097206679e-17 NA NA NA hsa-miR-194-5p UBLCP1 1.8992998339217 3.76507853301977e-10 -0.350621435734828 0.022834406362261 MirTarget -0.162256006341327 5.14295548739049e-12 NA NA NA hsa-miR-140-5p UBR1 0.844753502512594 3.73722278438606e-05 -0.870775603837103 1.62515391893457e-09 miRanda -0.147902321647895 1.79072039363397e-05 NA NA NA hsa-miR-140-5p UBR3 0.844753502512594 3.73722278438606e-05 -0.622051125375518 1.56787261031666e-05 miRanda -0.196486325145387 5.70848764891526e-09 NA NA NA hsa-miR-34a-5p UBR4 1.9016323452565 1.43092834643601e-14 -0.481351375109417 7.46877462227738e-06 miRNAWalker2_validate -0.117170347788259 6.73951838653931e-09 NA NA NA hsa-miR-140-5p UBXN10 0.844753502512594 3.73722278438606e-05 -0.784913510519013 0.0781279172998548 mirMAP -0.334604125693718 0.00147792778299535 NA NA NA hsa-miR-140-5p UBXN7 0.844753502512594 3.73722278438606e-05 0.00200501422604882 0.992854523204685 miRanda -0.137302407112063 0.00934531995746761 NA NA NA hsa-miR-152-3p UCP3 -0.0480232621705712 0.844347735441565 0.384477203561586 0.130972912323939 MirTarget -0.248407466729649 7.36667647597654e-07 NA NA NA hsa-miR-140-5p ULK2 0.844753502512594 3.73722278438606e-05 -0.582426572411284 0.00379371000646104 miRanda -0.184727637468753 9.90523092823506e-05 NA NA NA hsa-miR-194-5p UNC80 1.8992998339217 3.76507853301977e-10 -2.93254749119954 5.16004071775435e-10 miRNATAP -0.20734930766429 0.00599349587044455 NA NA NA hsa-miR-140-5p USP34 0.844753502512594 3.73722278438606e-05 -0.281220182838029 0.0133833434747705 miRanda -0.107948530713108 5.05530239870343e-05 NA NA NA hsa-miR-140-5p USP9Y 0.844753502512594 3.73722278438606e-05 0.928514266892167 0.381932048585525 PITA;miRanda -0.582646527949499 0.0204301762324791 NA NA NA hsa-miR-140-5p UTY 0.844753502512594 3.73722278438606e-05 1.1767057147679 0.265173194813156 miRanda -0.552146416974118 0.0272442492443314 NA NA NA hsa-miR-34a-5p VCL 1.9016323452565 1.43092834643601e-14 -1.42195933102912 9.04222123827734e-13 miRNAWalker2_validate;miRNATAP -0.246989410891453 9.46844298497881e-11 NA NA NA hsa-miR-140-5p VEZF1 0.844753502512594 3.73722278438606e-05 -0.623680936997776 2.54341270614942e-07 miRanda -0.137122495393819 1.63490448417159e-06 NA NA NA hsa-miR-140-5p VLDLR 0.844753502512594 3.73722278438606e-05 -1.24679016115614 0.000599286809743815 miRanda -0.495159454117814 5.7996938969577e-09 NA NA NA hsa-miR-140-5p VPS13A 0.844753502512594 3.73722278438606e-05 -0.277026505331682 0.16902796153012 miRanda -0.118782114731813 0.0125337540792818 NA NA NA hsa-miR-140-5p VPS13B 0.844753502512594 3.73722278438606e-05 -0.38726379904448 0.0267203474218186 mirMAP -0.143519145259577 0.00049243596148133 NA NA NA hsa-miR-140-5p VPS37A 0.844753502512594 3.73722278438606e-05 -0.535271615159588 0.000139570838024489 miRanda -0.10730267962115 0.00126376933926127 NA NA NA hsa-miR-152-3p VSIG10 -0.0480232621705712 0.844347735441565 0.543429810697949 0.0407710113093315 MirTarget -0.265750072940889 3.89288943937854e-07 NA NA NA hsa-miR-34a-5p WASF1 1.9016323452565 1.43092834643601e-14 0.514886362846972 0.0399579941525439 MirTarget;miRNATAP -0.280141476290894 2.41498973472405e-09 NA NA NA hsa-miR-34a-5p WASF2 1.9016323452565 1.43092834643601e-14 -0.801854983583159 1.10831629491092e-05 miRNAWalker2_validate;mirMAP -0.205707713726092 2.31658772645909e-09 NA NA NA hsa-miR-140-5p WDFY3 0.844753502512594 3.73722278438606e-05 -0.372573142679179 0.0186947364148318 MirTarget;PITA;miRanda -0.153259482604325 3.81728262912889e-05 NA NA NA hsa-miR-34a-5p WDFY4 1.9016323452565 1.43092834643601e-14 -1.52835958077685 0.00208595788951407 mirMAP -0.450629510294551 1.6756200761721e-06 NA NA NA hsa-miR-140-5p WEE1 0.844753502512594 3.73722278438606e-05 -1.40590862047516 1.76830074250163e-11 PITA;miRanda -0.114355447695376 0.0240987579505763 NA NA NA hsa-miR-140-5p WFDC2 0.844753502512594 3.73722278438606e-05 -0.565322079434498 0.324461321018019 miRanda -0.401533257676763 0.00304226068413607 NA NA NA hsa-miR-140-5p WLS 0.844753502512594 3.73722278438606e-05 -1.67157993726018 1.47047830128909e-07 miRanda -0.278133407668099 0.000254343951339898 NA NA NA hsa-miR-140-5p WNK2 0.844753502512594 3.73722278438606e-05 -1.22343800297196 0.026978589194323 MirTarget;PITA;miRanda -0.373763486987934 0.00432261934011185 NA NA NA hsa-miR-34a-5p WTIP 1.9016323452565 1.43092834643601e-14 -0.143470050488438 0.575976441100554 mirMAP -0.110268889910385 0.0238714346536238 NA NA NA hsa-miR-34a-5p XYLT1 1.9016323452565 1.43092834643601e-14 -1.15680000822774 0.00273654109630901 MirTarget;miRNATAP -0.249465213783621 0.000702853207918648 NA NA NA hsa-miR-140-5p ZBTB4 0.844753502512594 3.73722278438606e-05 -1.18036868632639 2.4625945711519e-17 mirMAP -0.282082833002976 9.84514903406439e-18 NA NA NA hsa-miR-140-5p ZBTB41 0.844753502512594 3.73722278438606e-05 0.256375692371071 0.0990440051203574 miRanda -0.103162366070637 0.00486475862977185 NA NA NA hsa-miR-140-5p ZBTB47 0.844753502512594 3.73722278438606e-05 -1.27249050834428 5.23741533445086e-13 mirMAP -0.242604839462713 8.82799119846514e-09 NA NA NA hsa-miR-140-5p ZBTB7A 0.844753502512594 3.73722278438606e-05 -0.398768770478349 0.00311436564749729 miRanda -0.16717803288099 1.10605252200532e-07 NA NA NA hsa-miR-140-5p ZBTB8A 0.844753502512594 3.73722278438606e-05 -0.311470536482052 0.00679367139385109 miRanda -0.106349288258385 8.15522909735056e-05 NA NA NA hsa-miR-140-5p ZC3H6 0.844753502512594 3.73722278438606e-05 -0.801602939620911 8.02588679745992e-06 miRanda -0.242688972703083 8.63200942431525e-09 NA NA NA hsa-miR-140-5p ZDHHC15 0.844753502512594 3.73722278438606e-05 -2.821890119317 1.80193983474815e-08 miRanda -0.373005388667656 0.001957587839654 NA NA NA hsa-miR-34a-5p ZDHHC15 1.9016323452565 1.43092834643601e-14 -2.821890119317 1.80193983474815e-08 MirTarget -0.539909556786311 1.69475923776528e-08 NA NA NA hsa-miR-152-3p ZDHHC23 -0.0480232621705712 0.844347735441565 1.38573954815051 1.46092390923618e-08 MirTarget -0.213517397813888 1.43086024991069e-05 NA NA NA hsa-miR-194-5p ZEB1 1.8992998339217 3.76507853301977e-10 -2.59416392469398 4.19342616481451e-16 miRNATAP -0.46479513430517 5.12082558925993e-21 NA NA NA hsa-miR-194-5p ZFHX4 1.8992998339217 3.76507853301977e-10 -2.72243653694716 1.46650038380412e-06 MirTarget;miRNATAP -0.729360426982864 2.89147619118293e-17 NA NA NA hsa-miR-34a-5p ZFHX4 1.9016323452565 1.43092834643601e-14 -2.72243653694716 1.46650038380412e-06 MirTarget;miRNATAP -0.904347969530743 6.19334195647492e-18 NA NA NA hsa-miR-34a-5p ZFR 1.9016323452565 1.43092834643601e-14 -0.244084007386841 0.0323653934875649 miRNAWalker2_validate -0.123658212702121 6.16140246348229e-09 NA NA NA hsa-miR-140-5p ZHX1 0.844753502512594 3.73722278438606e-05 -0.625556902224413 0.000866151466526185 miRNATAP -0.144151120047069 0.00119029360645798 NA NA NA hsa-miR-34a-5p ZHX2 1.9016323452565 1.43092834643601e-14 -1.0113703267308 3.68498992423451e-09 MirTarget -0.177218657756695 6.38669235356367e-08 NA NA NA hsa-miR-140-5p ZKSCAN1 0.844753502512594 3.73722278438606e-05 0.0517842156655846 0.806777994138988 miRanda -0.152734675318207 0.00219399596000599 NA NA NA hsa-miR-152-3p ZNF217 -0.0480232621705712 0.844347735441565 0.304361345363533 0.118432127591969 MirTarget -0.148939870898847 0.000114014765248425 NA NA NA hsa-miR-194-5p ZNF25 1.8992998339217 3.76507853301977e-10 -1.20036862235946 6.14085039950356e-14 miRNATAP -0.173471412712046 5.43364457067212e-12 NA NA NA hsa-miR-34a-5p ZNF281 1.9016323452565 1.43092834643601e-14 0.0416620203780278 0.888110347621826 MirTarget;miRNATAP -0.301625657038341 5.62977700534027e-08 NA NA NA hsa-miR-152-3p ZNF3 -0.0480232621705712 0.844347735441565 0.491093896044474 0.000272925459649919 MirTarget -0.14065596718478 1.25881862270088e-07 NA NA NA hsa-miR-140-5p ZNF41 0.844753502512594 3.73722278438606e-05 0.0926189412744822 0.59275336561562 miRanda -0.111953005766035 0.006068715209627 NA NA NA hsa-miR-140-5p ZNF441 0.844753502512594 3.73722278438606e-05 -0.145291470611898 0.450490226844853 miRanda -0.104756311530673 0.0211916337295003 NA NA NA hsa-miR-194-5p ZNF516 1.8992998339217 3.76507853301977e-10 -1.70455112707834 2.41525896684444e-07 MirTarget;miRNATAP -0.217640323540708 2.92813060176813e-05 NA NA NA hsa-miR-194-5p ZNF532 1.8992998339217 3.76507853301977e-10 -0.642348594400126 0.00482300004408463 miRNATAP -0.228856737368902 6.28298091905128e-11 NA NA NA hsa-miR-34a-5p ZNF532 1.9016323452565 1.43092834643601e-14 -0.642348594400126 0.00482300004408463 miRNATAP -0.347457661422715 1.21370996999873e-16 NA NA NA hsa-miR-34a-5p ZNF641 1.9016323452565 1.43092834643601e-14 -0.687739592791494 0.0034857735492281 MirTarget -0.213534611469374 1.62184062991974e-06 NA NA NA hsa-miR-140-5p ZNF654 0.844753502512594 3.73722278438606e-05 -0.391645181307299 0.00908636401620128 MirTarget;miRanda -0.113903024709291 0.00129789738061482 NA NA NA hsa-miR-140-5p ZNF662 0.844753502512594 3.73722278438606e-05 -1.15361670024712 0.0389617274434132 miRanda -0.514904619165537 9.25021368829938e-05 NA NA NA hsa-miR-152-3p ZNF665 -0.0480232621705712 0.844347735441565 -0.328329115064652 0.337527412074612 MirTarget -0.229232303273059 0.000745713490732491 NA NA NA hsa-miR-140-5p ZNF704 0.844753502512594 3.73722278438606e-05 -1.32996166013373 0.000556264090538653 miRanda;mirMAP -0.342492218425259 0.000174706167344087 NA NA NA hsa-miR-140-5p ZNF710 0.844753502512594 3.73722278438606e-05 -0.166758515976001 0.33741345363751 miRNATAP -0.103595185298542 0.0115135321760468 NA NA NA hsa-miR-140-5p ZNF770 0.844753502512594 3.73722278438606e-05 -0.331270190095851 0.0488735648291454 miRanda -0.174908222549161 9.109986289561e-06 NA NA NA hsa-miR-152-3p ZNF784 -0.0480232621705712 0.844347735441565 0.231720148405984 0.196200197637431 MirTarget -0.216691644859931 5.86886034874795e-10 NA NA NA hsa-miR-140-5p ZNF827 0.844753502512594 3.73722278438606e-05 -0.812315034694813 0.00778247218631827 miRanda;miRNATAP -0.361322074473333 4.4792336691244e-07 NA NA NA