miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-106b-5p APC -0.648901865047096 8.24870862048014e-09 0.178106776451097 0.0679159506996304 miRNAWalker2_validate;miRTarBase -0.152406181389829 0.000242059519728295 23087084 miR 106b downregulates adenomatous polyposis coli and promotes cell proliferation in human hepatocellular carcinoma; Moreover we demonstrated that miR-106b downregulates APC expression by directly targeting the 3'-untranslated region of APC messenger RNA; Taken together our results suggest that miR-106b plays an important role in promoting the proliferation of human hepatoma cells and presents a novel mechanism of micro RNA-mediated direct suppression of APC expression in cancer cells liver cancer hsa-miR-21-5p APC -1.51084295924322 1.54551622173292e-34 0.178106776451097 0.0679159506996304 miRNAWalker2_validate -0.170963654395431 1.15664392926358e-06 23773491;24832083 The prognostic significance of APC gene mutation and miR 21 expression in advanced stage colorectal cancer; The aim of this study was to analyse the association of APC gene mutation and miR-21 expression with clinical outcome in CRC patients; APC gene mutation and expression of APC and miR-21 were analysed by direct DNA sequencing and real-time reverse transcription polymerase chain reaction; APC gene expression was low in CRC and negatively correlated with miR-21 expression and gene mutation; In Taiwan downregulation of the APC gene in CRC correlated with gene mutation and miR-21 upregulation; APC mutation and miR-21 expression could be used to predict the clinical outcome of CRC especially in patients with advanced disease;MicroRNA 21 promotes tumour malignancy via increased nuclear translocation of β catenin and predicts poor outcome in APC mutated but not in APC wild type colorectal cancer; However in our preliminary data the prognostic value of miR-21 levels was observed only in adenomatous polyposis coli APC-mutated tumours not in APC-wild-type tumours; We enrolled 165 colorectal tumour to determine APC mutation miR-21 levels and nuclear β-catenin expression by direct sequencing real-time PCR and immunohistochemistry staging; colorectal cancer;colorectal cancer hsa-let-7a-5p APC2 0.328069937201908 0.000464344093743851 -1.72078641102954 8.65364092042873e-19 TargetScan -0.296144411661104 0.00537712418099154 NA NA NA hsa-miR-125a-5p APC2 0.912199693723822 1.38256246489542e-07 -1.72078641102954 8.65364092042873e-19 mirMAP -0.20354523468962 0.000295443314604665 NA NA NA hsa-miR-125b-5p APC2 1.35767721102906 1.1656461739517e-18 -1.72078641102954 8.65364092042873e-19 mirMAP -0.155769601278602 0.0116432392796282 NA NA NA hsa-miR-185-3p APC2 0.270845540360709 0.0853959272273836 -1.72078641102954 8.65364092042873e-19 MirTarget -0.128016984954642 0.042723463729063 NA NA NA hsa-miR-194-3p APC2 0.772747277805345 2.95374651701899e-05 -1.72078641102954 8.65364092042873e-19 mirMAP -0.172917552309453 0.00110754915341712 NA NA NA hsa-miR-199a-5p APC2 1.98848462405923 2.04216227137509e-11 -1.72078641102954 8.65364092042873e-19 mirMAP -0.101465825144385 0.0017784302528151 NA NA NA hsa-miR-20a-3p APC2 0.318177901603857 0.0467885456739852 -1.72078641102954 8.65364092042873e-19 mirMAP -0.246153342422663 6.72022408946292e-05 NA NA NA hsa-miR-2355-5p APC2 0.233446678887994 0.157909851771341 -1.72078641102954 8.65364092042873e-19 mirMAP -0.144630179726904 0.0161276667729214 NA NA NA hsa-miR-23b-5p APC2 1.05289229952702 7.22203199173863e-13 -1.72078641102954 8.65364092042873e-19 mirMAP -0.216017097324045 0.0012980633523771 NA NA NA hsa-miR-28-5p APC2 0.43096483059997 2.67367257252851e-06 -1.72078641102954 8.65364092042873e-19 mirMAP -0.301426627736638 0.00527080037286869 NA NA NA hsa-miR-340-3p APC2 0.329393899588904 0.00329627776838891 -1.72078641102954 8.65364092042873e-19 mirMAP -0.223534226946108 0.011828247947981 NA NA NA hsa-miR-505-5p APC2 0.768282569967004 1.14662846595398e-05 -1.72078641102954 8.65364092042873e-19 mirMAP -0.146052163078095 0.00923653240014872 NA NA NA hsa-miR-320a AXIN1 -0.325285936317327 0.0221415065838845 -0.298461396818582 0.00967766490234067 miRNAWalker2_validate -0.102922011670008 0.00946254716514405 NA NA NA hsa-let-7b-3p AXIN2 1.21979213547786 5.84575581584582e-17 -0.113841868770702 0.752977397700817 miRNATAP -0.270257334726793 0.0204955473660487 NA NA NA hsa-let-7g-3p AXIN2 1.14091000722297 8.3273601818868e-19 -0.113841868770702 0.752977397700817 MirTarget -0.333163518873582 0.0112609172880632 NA NA NA hsa-miR-15b-5p AXIN2 -0.23056694141356 0.0824765001857524 -0.113841868770702 0.752977397700817 miRTarBase;MirTarget;miRNATAP -0.445214007102522 0.000810754926318775 NA NA NA hsa-miR-16-2-3p AXIN2 0.0336420826463728 0.805158952566961 -0.113841868770702 0.752977397700817 mirMAP -0.637896819806337 6.99346379238779e-07 NA NA NA hsa-miR-16-5p AXIN2 0.39857723517961 0.000101598495180161 -0.113841868770702 0.752977397700817 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.492511513287746 0.00421170477125135 NA NA NA hsa-miR-195-3p AXIN2 1.09375690196245 4.70092324819816e-09 -0.113841868770702 0.752977397700817 mirMAP -0.313128484413814 0.000828518151480385 NA NA NA hsa-miR-195-5p AXIN2 1.85907534356434 1.47434041676385e-22 -0.113841868770702 0.752977397700817 MirTarget;miRNATAP -0.245874041969712 0.00506110437798971 NA NA NA hsa-miR-26b-3p AXIN2 1.25503731613309 4.45390890119649e-27 -0.113841868770702 0.752977397700817 MirTarget -0.591476065389494 2.94301063245798e-05 NA NA NA hsa-miR-326 AXIN2 1.881935132554 1.68087316863775e-21 -0.113841868770702 0.752977397700817 miRanda -0.362520003418692 1.98590653589597e-05 NA NA NA hsa-miR-338-5p AXIN2 0.221898432884725 0.252390988727086 -0.113841868770702 0.752977397700817 miRNATAP -0.342154956032422 0.000172654921949776 NA NA NA hsa-miR-424-5p AXIN2 2.62653257498508 2.38997974737922e-50 -0.113841868770702 0.752977397700817 MirTarget;miRNATAP -0.191832991796132 0.0301808709524209 NA NA NA hsa-miR-497-5p AXIN2 1.41371173021948 7.09278946477702e-17 -0.113841868770702 0.752977397700817 MirTarget;miRNATAP -0.294042209891213 0.00328690230713159 NA NA NA hsa-miR-616-3p AXIN2 0.699516741506972 1.82225985970288e-05 -0.113841868770702 0.752977397700817 MirTarget -0.422833368838949 7.60561180413777e-05 NA NA NA hsa-miR-15b-5p BTRC -0.23056694141356 0.0824765001857524 0.00218074865097284 0.976713248009886 MirTarget;miRNATAP -0.123880101738054 4.9294638073766e-06 NA NA NA hsa-miR-16-5p BTRC 0.39857723517961 0.000101598495180161 0.00218074865097284 0.976713248009886 miRNAWalker2_validate;MirTarget;miRNATAP -0.170550874702878 1.08874294937544e-06 NA NA NA hsa-miR-193a-3p BTRC 0.117675551589899 0.309391958208565 0.00218074865097284 0.976713248009886 MirTarget;miRanda -0.149422822918282 1.65168232460744e-06 NA NA NA hsa-miR-193b-3p BTRC 0.166697207281751 0.272022543069474 0.00218074865097284 0.976713248009886 miRNAWalker2_validate -0.163000762742341 2.75522541287735e-12 NA NA NA hsa-miR-361-3p BTRC -0.275658012727112 0.00549374744374472 0.00218074865097284 0.976713248009886 MirTarget;PITA;miRNATAP -0.103082226711992 0.00494622838999385 NA NA NA hsa-miR-497-5p BTRC 1.41371173021948 7.09278946477702e-17 0.00218074865097284 0.976713248009886 MirTarget;miRNATAP -0.112851166430765 2.51720614567891e-08 NA NA NA hsa-miR-505-3p BTRC 1.20027021591555 1.27927500175911e-13 0.00218074865097284 0.976713248009886 MirTarget -0.125291265362961 4.21412050838456e-09 NA NA NA hsa-miR-142-3p CACYBP 1.4243101967815 1.92609481097759e-14 -0.947814858405367 1.4921886438463e-19 miRanda -0.144814002750074 1.31409132658524e-07 NA NA NA hsa-miR-195-3p CACYBP 1.09375690196245 4.70092324819816e-09 -0.947814858405367 1.4921886438463e-19 mirMAP -0.152733395604941 5.33329826790323e-08 NA NA NA hsa-miR-26b-3p CACYBP 1.25503731613309 4.45390890119649e-27 -0.947814858405367 1.4921886438463e-19 MirTarget -0.260917629528483 7.49351372249007e-10 NA NA NA hsa-miR-30a-3p CACYBP 1.52720594401486 1.38300660757065e-17 -0.947814858405367 1.4921886438463e-19 MirTarget -0.221395044532441 1.38042138996782e-15 NA NA NA hsa-miR-30e-3p CACYBP 1.20845647373031 3.10263633528088e-25 -0.947814858405367 1.4921886438463e-19 MirTarget -0.346714737260252 1.1672915775241e-16 NA NA NA hsa-miR-576-5p CACYBP 0.37745200828585 0.00470735657343959 -0.947814858405367 1.4921886438463e-19 mirMAP -0.114264923477199 0.00428804012220945 NA NA NA hsa-miR-146b-3p CAMK2A 1.20799545896423 2.1985953089066e-09 0.327454379942137 0.356907439672439 miRNATAP -0.256569704205322 0.00225422031427031 NA NA NA hsa-miR-15b-3p CAMK2A -0.23810549043119 0.0997721500357466 0.327454379942137 0.356907439672439 mirMAP -0.441408376888264 0.000224916915481368 NA NA NA hsa-miR-21-3p CAMK2A 0.484219378716006 0.00299941098417659 0.327454379942137 0.356907439672439 MirTarget -0.428695676613169 4.7255606363298e-05 NA NA NA hsa-miR-25-3p CAMK2A -0.63306256355637 3.68686354834514e-10 0.327454379942137 0.356907439672439 MirTarget -0.353714687940178 0.0371404712484319 NA NA NA hsa-miR-582-3p CAMK2A 0.653831905315471 0.00248607706603279 0.327454379942137 0.356907439672439 mirMAP -0.238321516811749 0.00278890383023983 NA NA NA hsa-miR-7-1-3p CAMK2A 0.569105143287802 1.85297665041411e-05 0.327454379942137 0.356907439672439 MirTarget -0.357336167957049 0.00584245749670331 NA NA NA hsa-miR-10b-3p CAMK2B -2.77189254628215 2.26687582932635e-20 3.79443915567367 4.19182064533692e-17 mirMAP -0.454957383759527 4.10184640844674e-09 NA NA NA hsa-miR-10b-5p CAMK2B -2.86931593037303 6.97409423207806e-23 3.79443915567367 4.19182064533692e-17 miRNATAP -0.417096014841303 1.21569971542912e-08 NA NA NA hsa-miR-140-3p CAMK2B -0.546012239205325 4.84578261098881e-11 3.79443915567367 4.19182064533692e-17 mirMAP -1.81411614260735 1.20529878439456e-11 NA NA NA hsa-miR-186-5p CAMK2B 0.0601033913736888 0.535288717081192 3.79443915567367 4.19182064533692e-17 miRNAWalker2_validate;miRNATAP -0.96780834136333 4.81115064147646e-05 NA NA NA hsa-miR-18a-5p CAMK2B -0.918028187958705 1.90229510425328e-05 3.79443915567367 4.19182064533692e-17 mirMAP -0.422690423214241 5.82617560664156e-05 NA NA NA hsa-miR-34a-5p CAMK2B -1.03694231790864 5.7486401954075e-14 3.79443915567367 4.19182064533692e-17 mirMAP -0.516635641071732 0.00134707229894061 NA NA NA hsa-miR-362-3p CAMK2B -0.814007335895912 2.00108618836575e-09 3.79443915567367 4.19182064533692e-17 miRanda -0.352680482285307 0.0341415268531035 NA NA NA hsa-miR-362-5p CAMK2B -0.717921690799307 1.68392734504546e-05 3.79443915567367 4.19182064533692e-17 miRNATAP -0.345431989026884 0.0112947317909911 NA NA NA hsa-miR-3913-5p CAMK2B -0.247553671224336 0.0627950110811883 3.79443915567367 4.19182064533692e-17 mirMAP -0.405706782419066 0.0194271704247215 NA NA NA hsa-miR-589-3p CAMK2B -1.16846704028095 5.88525574424201e-11 3.79443915567367 4.19182064533692e-17 MirTarget -0.778879183962213 6.21351266377714e-10 NA NA NA hsa-miR-185-5p CAMK2D -0.480006257154714 6.35758891340259e-07 0.687180644274416 8.45246757593352e-14 miRNATAP -0.234239041033373 7.40060272982861e-07 NA NA NA hsa-miR-361-5p CAMK2D -0.233202959858694 0.00961572812255393 0.687180644274416 8.45246757593352e-14 PITA;miRanda;miRNATAP -0.118209860500318 0.0227624989042643 NA NA NA hsa-miR-16-5p CAMK2G 0.39857723517961 0.000101598495180161 -0.576340676979712 4.27895494044654e-14 miRNAWalker2_validate -0.135871265943338 0.000261518380420943 NA NA NA hsa-miR-195-3p CAMK2G 1.09375690196245 4.70092324819816e-09 -0.576340676979712 4.27895494044654e-14 mirMAP -0.104476343553057 2.09763143219786e-07 NA NA NA hsa-miR-1976 CAMK2G 0.431472440543166 0.00324575010550949 -0.576340676979712 4.27895494044654e-14 MirTarget -0.102016754320286 8.34056004410933e-05 NA NA NA hsa-miR-30e-3p CAMK2G 1.20845647373031 3.10263633528088e-25 -0.576340676979712 4.27895494044654e-14 MirTarget -0.11996903246946 0.000104033180079318 NA NA NA hsa-miR-484 CAMK2G -0.0857240033709612 0.453982056282252 -0.576340676979712 4.27895494044654e-14 mirMAP -0.106622523037446 0.00151220984601342 NA NA NA hsa-miR-628-5p CAMK2G 0.714131904567585 3.99119002614271e-08 -0.576340676979712 4.27895494044654e-14 MirTarget;PITA;miRNATAP -0.106189345393338 0.000243038442100515 NA NA NA hsa-miR-106a-5p CCND1 0.464229535269237 0.00972494435804678 0.901747452525997 1.22363850855719e-05 MirTarget;miRNATAP -0.262282596122017 2.76721397734651e-06 NA NA NA hsa-miR-106b-5p CCND1 -0.648901865047096 8.24870862048014e-09 0.901747452525997 1.22363850855719e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.430796355484411 1.07010119372681e-06 NA NA NA hsa-miR-1266-5p CCND1 -1.6344248374643 4.09278929749896e-13 0.901747452525997 1.22363850855719e-05 MirTarget -0.234489057674296 5.64471200142146e-08 NA NA NA hsa-miR-15b-5p CCND1 -0.23056694141356 0.0824765001857524 0.901747452525997 1.22363850855719e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.544455359613115 3.17021042565567e-13 NA NA NA hsa-miR-16-5p CCND1 0.39857723517961 0.000101598495180161 0.901747452525997 1.22363850855719e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.309506657035983 0.00178218906910022 23991964;22922827;18483394 At the molecular level our results further revealed that cyclin D1 expression was negatively regulated by miR-16;CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR;Truncation in CCND1 mRNA alters miR 16 1 regulation in mantle cell lymphoma; Furthermore we demonstrated that this truncation alters miR-16-1 binding sites and through the use of reporter constructs we were able to show that miR-16-1 regulates CCND1 mRNA expression; This study introduces the role of miR-16-1 in the regulation of CCND1 in MCL ;; bladder cancer;sarcoma;lymphoma hsa-miR-17-5p CCND1 -0.698861147045456 2.43854106455432e-05 0.901747452525997 1.22363850855719e-05 miRNAWalker2_validate;MirTarget;TargetScan;miRNATAP -0.343463418912801 9.97512783987264e-09 26431674 Bioinformatics Prediction and In Vitro Analysis Revealed That miR 17 Targets Cyclin D1 mRNA in Triple Negative Breast Cancer Cells; In this study using bioinformatic analyses miR-17 was selected as it targets the 3'UTR of CCND1 gene with the highest score; After lentiviral transduction of miR-17 to the target cells gene expression analysis showed decreased expression of CCND1 gene breast cancer hsa-miR-186-5p CCND1 0.0601033913736888 0.535288717081192 0.901747452525997 1.22363850855719e-05 mirMAP -0.315936974513477 0.00286438511586306 NA NA NA hsa-miR-193a-3p CCND1 0.117675551589899 0.309391958208565 0.901747452525997 1.22363850855719e-05 MirTarget;PITA;miRanda -0.209180766181781 0.0180609153505735 NA NA NA hsa-miR-19a-3p CCND1 -1.01712596153671 2.57753201450637e-07 0.901747452525997 1.22363850855719e-05 miRNAWalker2_validate;miRTarBase;miRNATAP -0.283475432466515 1.38758823633513e-08 25985117 Moreover miR-19a might play inhibitory roles in HCC malignancy via regulating Cyclin D1 expression liver cancer hsa-miR-19b-1-5p CCND1 0.277804782598542 0.0783067794722873 0.901747452525997 1.22363850855719e-05 miRNAWalker2_validate;miRTarBase -0.307712037252966 1.4364183273616e-06 NA NA NA hsa-miR-19b-3p CCND1 -0.601279551368823 0.000166850970852514 0.901747452525997 1.22363850855719e-05 miRNATAP -0.340975400639976 4.6454998539434e-08 NA NA NA hsa-miR-20a-5p CCND1 -0.854326758726998 5.04256669663367e-07 0.901747452525997 1.22363850855719e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.332506713675419 1.04479750525145e-08 NA NA NA hsa-miR-20b-5p CCND1 -0.457668023910378 0.0285865211936159 0.901747452525997 1.22363850855719e-05 MirTarget;miRNATAP -0.230429652941375 1.603682834845e-06 NA NA NA hsa-miR-340-5p CCND1 0.0047761453138202 0.968502722773762 0.901747452525997 1.22363850855719e-05 mirMAP -0.322810275002772 0.000125999869952101 NA NA NA hsa-miR-425-5p CCND1 -0.585974239943861 2.23063410931427e-05 0.901747452525997 1.22363850855719e-05 miRNAWalker2_validate -0.385144136522737 9.38557217850495e-08 NA NA NA hsa-miR-503-5p CCND1 -0.191949282338045 0.268420664548102 0.901747452525997 1.22363850855719e-05 miRNAWalker2_validate;miRTarBase;MirTarget -0.155187994375291 0.00815133470022587 26047605;23731275 MiR 503 inhibited cell proliferation of human breast cancer cells by suppressing CCND1 expression; Overexpression of miR-503 in breast cancer cell lines reduced cell proliferation through inducing G0/G1 cell cycle arrest by targeting CCND1;MicroRNA 503 suppresses proliferation and cell cycle progression of endometrioid endometrial cancer by negatively regulating cyclin D1; CCND1 has a binding sequence of miR-503 within its 3' untranslated region and was confirmed to be a direct target of miR-503 by the fluorescent reporter assays; Increasing the miR-503 level in EEC cells suppressed cell viability colon formation activity and cell-cycle progression and the inhibited oncogenic phenotypes induced by miR-503 were alleviated by ectopic expression of CCND1 without the untranslated region sequence; Collectively this study suggested that miR-503 plays a tumor-suppressor role by targeting CCND1; Abnormal suppression of miR-503 leads to an increase in the CCND1 level which may promote carcinogenesis and progression of EEC ;progression;tumorigenesis breast cancer;endometrial cancer hsa-miR-589-3p CCND1 -1.16846704028095 5.88525574424201e-11 0.901747452525997 1.22363850855719e-05 MirTarget -0.183119037529565 0.00124255651400669 NA NA NA hsa-miR-616-5p CCND1 -0.15056990463822 0.402836556304531 0.901747452525997 1.22363850855719e-05 mirMAP -0.256039244652268 5.24430962347992e-06 NA NA NA hsa-miR-7-1-3p CCND1 0.569105143287802 1.85297665041411e-05 0.901747452525997 1.22363850855719e-05 mirMAP -0.260985322289835 0.000573950021646959 NA NA NA hsa-miR-9-5p CCND1 -1.26407994492898 8.53156156439901e-05 0.901747452525997 1.22363850855719e-05 miRNAWalker2_validate -0.136746717035529 1.04306605002938e-05 NA NA NA hsa-miR-92a-3p CCND1 -0.212391012518189 0.134292268090006 0.901747452525997 1.22363850855719e-05 miRNAWalker2_validate -0.407898716180535 8.06773614790968e-09 NA NA NA hsa-miR-93-5p CCND1 -1.39518349670952 2.84167728726739e-25 0.901747452525997 1.22363850855719e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.335918242999821 2.01286203755089e-06 NA NA NA hsa-miR-942-5p CCND1 -0.346451845105261 0.0283255399972349 0.901747452525997 1.22363850855719e-05 MirTarget -0.245807225430864 0.000123103109119178 NA NA NA hsa-miR-130b-5p CCND2 -0.170599813152403 0.337611586432785 -0.35645116038227 0.0365641518216505 mirMAP -0.174593683703476 0.000182311423622 NA NA NA hsa-miR-17-5p CCND2 -0.698861147045456 2.43854106455432e-05 -0.35645116038227 0.0365641518216505 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.113015688947626 0.0235787855141743 NA NA NA hsa-miR-186-5p CCND2 0.0601033913736888 0.535288717081192 -0.35645116038227 0.0365641518216505 mirMAP;miRNATAP -0.193600795480126 0.0260868894007342 NA NA NA hsa-miR-19b-3p CCND2 -0.601279551368823 0.000166850970852514 -0.35645116038227 0.0365641518216505 miRNAWalker2_validate;MirTarget;miRNATAP -0.119904158273959 0.0208215571869961 NA NA NA hsa-miR-20a-5p CCND2 -0.854326758726998 5.04256669663367e-07 -0.35645116038227 0.0365641518216505 miRNAWalker2_validate;miRTarBase;miRNATAP -0.156120931730772 0.0012098497067071 NA NA NA hsa-miR-26b-5p CCND2 1.10804856399745 4.14176110313907e-22 -0.35645116038227 0.0365641518216505 mirMAP;miRNATAP -0.15630559256768 0.0241870958823073 NA NA NA hsa-miR-28-5p CCND2 0.43096483059997 2.67367257252851e-06 -0.35645116038227 0.0365641518216505 miRanda -0.482733599739849 7.0104175669049e-08 NA NA NA hsa-miR-30e-3p CCND2 1.20845647373031 3.10263633528088e-25 -0.35645116038227 0.0365641518216505 mirMAP -0.172556640657028 0.0107106227721611 NA NA NA hsa-miR-32-3p CCND2 -0.219109440121582 0.207217051619542 -0.35645116038227 0.0365641518216505 mirMAP -0.100180602356121 0.0435638483123248 NA NA NA hsa-miR-33a-3p CCND2 0.683025859637737 1.01106097756419e-05 -0.35645116038227 0.0365641518216505 MirTarget -0.263538375258973 6.17940317063527e-07 NA NA NA hsa-miR-3607-3p CCND2 2.15518588554494 1.03390728226714e-23 -0.35645116038227 0.0365641518216505 mirMAP -0.12362922199284 0.000700039964538526 NA NA NA hsa-miR-378a-3p CCND2 1.1920055906972 3.23538871733595e-10 -0.35645116038227 0.0365641518216505 miRNAWalker2_validate -0.183441253857915 1.70039721501862e-05 NA NA NA hsa-miR-548v CCND2 0.27258775900243 0.176259917595269 -0.35645116038227 0.0365641518216505 MirTarget -0.149460521918892 0.000339780804187451 NA NA NA hsa-miR-590-5p CCND2 0.103355559980407 0.310027295317082 -0.35645116038227 0.0365641518216505 mirMAP -0.211966584315608 0.0103091905406705 NA NA NA hsa-miR-616-5p CCND2 -0.15056990463822 0.402836556304531 -0.35645116038227 0.0365641518216505 mirMAP -0.315443515897926 3.35063962863299e-12 NA NA NA hsa-miR-618 CCND2 -0.13539895350352 0.517145913114103 -0.35645116038227 0.0365641518216505 mirMAP -0.225947558771367 2.79586020953898e-08 NA NA NA hsa-miR-93-5p CCND2 -1.39518349670952 2.84167728726739e-25 -0.35645116038227 0.0365641518216505 miRNATAP -0.124190209461302 0.0339027005116383 NA NA NA hsa-miR-27b-3p CCND3 0.823491817819763 9.20935302746338e-14 -0.0767102129984076 0.478427267753338 miRNAWalker2_validate -0.236832359235505 2.50262257150465e-07 NA NA NA hsa-miR-28-5p CCND3 0.43096483059997 2.67367257252851e-06 -0.0767102129984076 0.478427267753338 miRNATAP -0.138639491175911 0.0156945612199004 NA NA NA hsa-miR-320a CCND3 -0.325285936317327 0.0221415065838845 -0.0767102129984076 0.478427267753338 miRanda -0.118523664136384 0.00134906533817398 NA NA NA hsa-miR-140-5p CHD8 0.220106443070148 0.0140713197101226 -0.324088701647041 6.43045234411584e-07 miRanda -0.104530115671165 0.00368773349126809 NA NA NA hsa-miR-582-5p CHP2 0.680189083316822 0.00103755166534107 -0.854063239964795 0.0342924238659999 miRNATAP -0.215180348806887 0.0235896474657227 NA NA NA hsa-miR-324-3p CREBBP -0.260348469146492 0.0506141704203561 0.198953226514462 0.0138678371438253 miRNAWalker2_validate -0.122219674872295 3.31240083157391e-05 NA NA NA hsa-miR-330-5p CREBBP -0.442231058604098 0.00533085608438092 0.198953226514462 0.0138678371438253 miRanda -0.10760918491025 1.18364633640293e-05 NA NA NA hsa-miR-769-5p CREBBP -0.219661452072769 0.0333425465750595 0.198953226514462 0.0138678371438253 miRNAWalker2_validate -0.128844707446474 0.00077006671697313 NA NA NA hsa-miR-16-1-3p CSNK1A1 -0.392360028038556 0.00112481918108207 0.337358696279794 1.0388780822189e-09 mirMAP -0.116468067412102 1.87200721471436e-07 NA NA NA hsa-miR-19b-3p CSNK1A1 -0.601279551368823 0.000166850970852514 0.337358696279794 1.0388780822189e-09 mirMAP -0.102374765378003 7.70223411359268e-10 NA NA NA hsa-miR-21-5p CSNK1A1 -1.51084295924322 1.54551622173292e-34 0.337358696279794 1.0388780822189e-09 miRNAWalker2_validate -0.104077813571288 2.3200921239842e-07 NA NA NA hsa-miR-501-3p CSNK1A1 -0.999540908940091 2.77358485582016e-11 0.337358696279794 1.0388780822189e-09 TargetScan;miRNATAP -0.104354920023566 2.1202153173049e-09 NA NA NA hsa-miR-502-3p CSNK1A1 -0.659598854007547 3.01316453996411e-08 0.337358696279794 1.0388780822189e-09 miRNATAP -0.11313105011664 4.24084177258773e-07 NA NA NA hsa-miR-148a-5p CSNK1E 0.767626696027764 1.08359477494785e-06 -0.608336779934032 9.5678079561362e-12 miRNATAP -0.245152102120518 4.84178312131527e-20 NA NA NA hsa-miR-195-3p CSNK1E 1.09375690196245 4.70092324819816e-09 -0.608336779934032 9.5678079561362e-12 miRNATAP -0.104078083921822 9.86380539775099e-06 NA NA NA hsa-let-7c-5p CSNK2A1 1.70744661345097 2.87934212005881e-20 -0.311613292322926 6.17228757338999e-05 miRNAWalker2_validate -0.118081213291704 8.22763425873157e-10 NA NA NA hsa-miR-125b-5p CSNK2A1 1.35767721102906 1.1656461739517e-18 -0.311613292322926 6.17228757338999e-05 MirTarget;miRNATAP -0.149030754925627 1.35154941408146e-10 NA NA NA hsa-miR-22-3p CSNK2A1 0.628561621952411 1.33755558015497e-09 -0.311613292322926 6.17228757338999e-05 miRNAWalker2_validate -0.313593609077037 1.67312457705441e-19 NA NA NA hsa-miR-30c-5p CSNK2A2 0.432111642767637 0.000159764714930976 -0.0716365631905194 0.389146554448828 mirMAP -0.107697084400435 0.00221143602273193 NA NA NA hsa-miR-30e-3p CSNK2A2 1.20845647373031 3.10263633528088e-25 -0.0716365631905194 0.389146554448828 mirMAP -0.102198234963169 0.00178623723694858 NA NA NA hsa-miR-146b-5p CTBP2 -0.41971954679544 0.0457375823220201 0.393179189490341 0.0225071278697853 miRanda -0.176036756804994 9.21105923068651e-06 NA NA NA hsa-miR-616-5p CTBP2 -0.15056990463822 0.402836556304531 0.393179189490341 0.0225071278697853 mirMAP -0.312610374730466 9.41444908463415e-12 NA NA NA hsa-miR-618 CTBP2 -0.13539895350352 0.517145913114103 0.393179189490341 0.0225071278697853 MirTarget;PITA -0.334800818337328 8.46589457931172e-17 NA NA NA hsa-miR-330-3p CTNNB1 0.332364259424489 0.0316051913061457 -0.00180452674839771 0.983564078864438 MirTarget;PITA;miRNATAP -0.128940103294471 3.76576237893285e-06 NA NA NA hsa-miR-331-3p CTNNB1 0.283974346994632 0.037378541105322 -0.00180452674839771 0.983564078864438 miRNAWalker2_validate -0.113207881387487 0.000273720190926097 NA NA NA hsa-miR-10a-5p CTNNBIP1 1.47723516092033 7.27299669108542e-16 -0.140232312201227 0.147963042657655 miRNATAP -0.118062211432091 1.54161147845247e-06 NA NA NA hsa-miR-23a-3p CTNNBIP1 0.178875974460576 0.1359782735406 -0.140232312201227 0.147963042657655 MirTarget;miRNATAP -0.189688066747386 1.24474286715309e-06 NA NA NA hsa-miR-26a-5p CTNNBIP1 0.963792031426847 1.83360999387309e-22 -0.140232312201227 0.147963042657655 miRNATAP -0.121359817445263 0.007749992860808 NA NA NA hsa-miR-29a-3p CTNNBIP1 0.856762511178141 4.65330336378316e-12 -0.140232312201227 0.147963042657655 MirTarget;miRNATAP -0.128675201414392 0.00052389516655892 NA NA NA hsa-miR-92b-3p CTNNBIP1 -0.220374930803972 0.296187538889097 -0.140232312201227 0.147963042657655 miRNATAP -0.100393277173108 5.88829524689744e-06 NA NA NA hsa-miR-27a-3p CUL1 0.37080738041511 0.00875721956202742 0.117901782494854 0.102284488383872 miRNAWalker2_validate -0.100449098638373 4.43211535246804e-05 NA NA NA hsa-miR-130b-3p DAAM1 -0.687190305027545 0.000109068658562257 0.820319075229238 3.1612203091122e-05 MirTarget;miRNATAP -0.230438739665998 1.89403317991823e-05 NA NA NA hsa-miR-130b-5p DAAM1 -0.170599813152403 0.337611586432785 0.820319075229238 3.1612203091122e-05 MirTarget -0.133084117469404 0.014855813976074 NA NA NA hsa-miR-181a-5p DAAM1 -0.25011343590295 0.0551933249319328 0.820319075229238 3.1612203091122e-05 mirMAP -0.206291476669735 0.00568464658531029 NA NA NA hsa-miR-181b-5p DAAM1 -0.488256489401109 0.00105321129419699 0.820319075229238 3.1612203091122e-05 mirMAP -0.244543574167562 0.000154525603721181 NA NA NA hsa-miR-183-5p DAAM1 -2.33444328833177 1.52188109365421e-10 0.820319075229238 3.1612203091122e-05 MirTarget;miRNATAP -0.109601186169797 2.10092575174277e-05 NA NA NA hsa-miR-19a-3p DAAM1 -1.01712596153671 2.57753201450637e-07 0.820319075229238 3.1612203091122e-05 miRNATAP -0.220126605454463 4.55479106103419e-06 NA NA NA hsa-miR-19b-3p DAAM1 -0.601279551368823 0.000166850970852514 0.820319075229238 3.1612203091122e-05 miRNATAP -0.251357652633507 2.81850564678398e-05 NA NA NA hsa-miR-21-5p DAAM1 -1.51084295924322 1.54551622173292e-34 0.820319075229238 3.1612203091122e-05 miRNAWalker2_validate -0.578036099340168 1.45141919650478e-16 NA NA NA hsa-miR-301a-3p DAAM1 -0.84291051164036 1.43446467417895e-06 0.820319075229238 3.1612203091122e-05 MirTarget;miRNATAP -0.221373325761519 4.89015141234831e-05 NA NA NA hsa-miR-362-3p DAAM1 -0.814007335895912 2.00108618836575e-09 0.820319075229238 3.1612203091122e-05 MirTarget;miRanda;miRNATAP -0.19953143276621 0.00451703685771936 NA NA NA hsa-miR-452-5p DAAM1 -1.91544498799507 1.81995982853342e-14 0.820319075229238 3.1612203091122e-05 MirTarget -0.128524206630459 0.000583790339994043 NA NA NA hsa-miR-500a-3p DAAM1 -1.18913245435488 1.5951689034138e-16 0.820319075229238 3.1612203091122e-05 MirTarget -0.172185465678666 0.00798226327576634 NA NA NA hsa-miR-548j-5p DAAM1 -0.251239647701947 0.171361975450223 0.820319075229238 3.1612203091122e-05 MirTarget -0.195072210611623 0.000335073361311463 NA NA NA hsa-miR-92a-3p DAAM1 -0.212391012518189 0.134292268090006 0.820319075229238 3.1612203091122e-05 miRNATAP -0.329316230547128 1.24853835658816e-06 NA NA NA hsa-miR-92b-3p DAAM1 -0.220374930803972 0.296187538889097 0.820319075229238 3.1612203091122e-05 miRNATAP -0.188020657312111 3.90463524874401e-05 NA NA NA hsa-miR-146b-5p DAAM2 -0.41971954679544 0.0457375823220201 0.827336419502446 6.34713523968999e-05 miRanda -0.119810383092939 0.0132408049997276 NA NA NA hsa-miR-182-5p DAAM2 -1.96601340710222 4.39326175603683e-09 0.827336419502446 6.34713523968999e-05 mirMAP -0.151231784560416 2.6298365470906e-07 NA NA NA hsa-miR-18a-5p DAAM2 -0.918028187958705 1.90229510425328e-05 0.827336419502446 6.34713523968999e-05 miRNAWalker2_validate -0.316653308627821 4.58755922306922e-12 NA NA NA hsa-miR-193a-3p DAAM2 0.117675551589899 0.309391958208565 0.827336419502446 6.34713523968999e-05 miRanda -0.341711924634843 0.000104918704787674 NA NA NA hsa-miR-19b-3p DAAM2 -0.601279551368823 0.000166850970852514 0.827336419502446 6.34713523968999e-05 miRNAWalker2_validate -0.245450167728416 9.86406700949337e-05 NA NA NA hsa-miR-339-5p DAAM2 -0.28058991987842 0.0355660282647232 0.827336419502446 6.34713523968999e-05 miRanda -0.413344354790584 4.14363634293648e-08 NA NA NA hsa-miR-421 DAAM2 -0.94185633469408 6.12167297054091e-08 0.827336419502446 6.34713523968999e-05 PITA;miRanda -0.188129998365284 0.00111302775744293 NA NA NA hsa-miR-589-3p DAAM2 -1.16846704028095 5.88525574424201e-11 0.827336419502446 6.34713523968999e-05 mirMAP -0.209473700713847 0.000219288033114949 NA NA NA hsa-miR-29a-3p DKK1 0.856762511178141 4.65330336378316e-12 -2.53841627649576 5.46380849566478e-06 miRNAWalker2_validate;miRTarBase -1.2101636118785 1.65540639532224e-08 NA NA NA hsa-miR-324-5p DKK2 -0.372933276649779 0.00592280066108939 -0.712159035258033 0.0313122411685687 miRanda -0.291951134890784 0.0145021240821494 NA NA NA hsa-miR-33a-3p DKK2 0.683025859637737 1.01106097756419e-05 -0.712159035258033 0.0313122411685687 mirMAP -0.398468507768241 0.000114088043705476 NA NA NA hsa-miR-3607-3p DKK2 2.15518588554494 1.03390728226714e-23 -0.712159035258033 0.0313122411685687 miRNATAP -0.220648396449356 0.00186051493970931 NA NA NA hsa-miR-361-5p DKK2 -0.233202959858694 0.00961572812255393 -0.712159035258033 0.0313122411685687 miRanda -0.656715068207467 0.000279767365569126 NA NA NA hsa-miR-374a-5p DKK2 -0.0163903637472993 0.869784217438642 -0.712159035258033 0.0313122411685687 mirMAP -0.769067427863519 2.07316416575001e-06 NA NA NA hsa-miR-374b-5p DKK2 0.307538028546427 0.00300796175459694 -0.712159035258033 0.0313122411685687 mirMAP -0.802994528462122 2.17749870933731e-07 NA NA NA hsa-miR-455-5p DKK2 0.270546034117159 0.0581320703577714 -0.712159035258033 0.0313122411685687 miRanda -0.451655268783954 6.27129067973938e-05 NA NA NA hsa-miR-486-5p DKK2 1.77766890600023 2.90717179299196e-14 -0.712159035258033 0.0313122411685687 miRanda;miRNATAP -0.272966847164131 3.97101723357271e-05 NA NA NA hsa-miR-590-3p DKK2 0.47316749804781 1.76652934637215e-05 -0.712159035258033 0.0313122411685687 miRanda;mirMAP;miRNATAP -0.513273510317679 0.000433479835754034 NA NA NA hsa-miR-590-5p DKK2 0.103355559980407 0.310027295317082 -0.712159035258033 0.0313122411685687 miRanda -0.740681523990746 3.20086563969699e-06 NA NA NA hsa-miR-335-5p DKK4 1.61347836513558 1.62757083289686e-19 -1.45705615286137 0.0069106179593896 miRNAWalker2_validate -0.644570128381493 4.17056510573926e-06 NA NA NA hsa-miR-10a-5p DVL1 1.47723516092033 7.27299669108542e-16 -0.0974490868963747 0.351327376305355 miRNAWalker2_validate -0.122692252559585 3.72861974540746e-06 NA NA NA hsa-miR-27a-3p DVL2 0.37080738041511 0.00875721956202742 -0.932937814675563 4.78146420278841e-20 miRNATAP -0.102448960625914 0.00526923611599277 NA NA NA hsa-miR-27b-3p DVL2 0.823491817819763 9.20935302746338e-14 -0.932937814675563 4.78146420278841e-20 miRNATAP -0.221394297021235 1.09073127725023e-06 NA NA NA hsa-miR-28-5p DVL2 0.43096483059997 2.67367257252851e-06 -0.932937814675563 4.78146420278841e-20 miRanda -0.124965107066794 0.0275166078238653 NA NA NA hsa-miR-125b-5p DVL3 1.35767721102906 1.1656461739517e-18 -0.60932169895587 3.59083763972316e-15 miRNATAP -0.128110031624996 8.52754629911134e-08 NA NA NA hsa-miR-26b-5p DVL3 1.10804856399745 4.14176110313907e-22 -0.60932169895587 3.59083763972316e-15 miRNAWalker2_validate -0.111951369829111 0.000527706771327525 NA NA NA hsa-miR-29b-2-5p DVL3 0.223258653034776 0.0843061465199331 -0.60932169895587 3.59083763972316e-15 MirTarget -0.104468815670416 0.000526336007952701 NA NA NA hsa-miR-22-3p EP300 0.628561621952411 1.33755558015497e-09 0.200382966790078 0.0704945874784133 MirTarget;miRNATAP -0.102672783880902 0.0463193353503437 NA NA NA hsa-miR-30d-3p EP300 0.120562286038761 0.32954953478212 0.200382966790078 0.0704945874784133 MirTarget;miRNATAP -0.106915117943506 0.0149374124449437 NA NA NA hsa-miR-339-5p EP300 -0.28058991987842 0.0355660282647232 0.200382966790078 0.0704945874784133 miRanda -0.157358640254018 9.53193539159902e-05 NA NA NA hsa-miR-342-3p EP300 0.31967731498426 0.0449813878317159 0.200382966790078 0.0704945874784133 MirTarget;PITA;miRanda;miRNATAP -0.112632997815777 0.000853079257159957 NA NA NA hsa-miR-361-3p EP300 -0.275658012727112 0.00549374744374472 0.200382966790078 0.0704945874784133 PITA -0.113790418081702 0.0379052782907214 NA NA NA hsa-miR-16-1-3p FBXW11 -0.392360028038556 0.00112481918108207 -0.0471132174286852 0.541930794061266 MirTarget -0.108794263042156 0.000448893797575061 NA NA NA hsa-miR-19a-3p FOSL1 -1.01712596153671 2.57753201450637e-07 1.28809880442401 1.10466405136616e-07 MirTarget -0.172041574882293 0.00411622412360713 23831570 MicroRNA 19a 3p inhibits breast cancer progression and metastasis by inducing macrophage polarization through downregulated expression of Fra 1 proto oncogene; In addition we could measure the activity of binding between miR-19a-3p and Fra-1 with a psiCHECK luciferase reporter system; Taken together these findings indicate that miR-19a-3p is capable of downregulating the M2 phenotype in M2 macrophages and that the low expression of this miRNA has an important role in the upregulation of Fra-1 expression and induction of M2 macrophage polarization metastasis;progression breast cancer hsa-miR-19b-3p FOSL1 -0.601279551368823 0.000166850970852514 1.28809880442401 1.10466405136616e-07 MirTarget -0.20838470159538 0.00535183413101081 NA NA NA hsa-miR-30a-3p FRAT1 1.52720594401486 1.38300660757065e-17 -0.185193084077381 0.157275995008766 miRNATAP -0.14668409784478 1.58066790384591e-05 NA NA NA hsa-miR-125b-5p FRAT2 1.35767721102906 1.1656461739517e-18 -0.225546147167741 0.0512402780577892 miRNAWalker2_validate;miRNATAP -0.192240928679307 2.74806554357597e-08 NA NA NA hsa-miR-22-3p FRAT2 0.628561621952411 1.33755558015497e-09 -0.225546147167741 0.0512402780577892 miRNAWalker2_validate;MirTarget;miRNATAP -0.232862193711047 1.27800322792138e-05 NA NA NA hsa-miR-26b-5p FRAT2 1.10804856399745 4.14176110313907e-22 -0.225546147167741 0.0512402780577892 miRNATAP -0.113710778989664 0.0154231022549634 NA NA NA hsa-miR-29a-3p FRAT2 0.856762511178141 4.65330336378316e-12 -0.225546147167741 0.0512402780577892 miRNATAP -0.212098851485806 1.50511690465606e-06 NA NA NA hsa-miR-29b-3p FRAT2 0.348885528720526 0.0121441341291263 -0.225546147167741 0.0512402780577892 miRNATAP -0.181123094050768 6.77620586159878e-06 NA NA NA hsa-miR-29c-3p FRAT2 1.4367517608807 1.61767774905732e-21 -0.225546147167741 0.0512402780577892 miRNATAP -0.195012447145813 2.66822962952396e-08 NA NA NA hsa-miR-146b-5p FZD1 -0.41971954679544 0.0457375823220201 0.99065551244753 2.10933438723929e-07 MirTarget;PITA;miRanda -0.181547752240403 4.76064172222519e-05 NA NA NA hsa-miR-192-5p FZD1 0.50188499512787 0.00344713341196035 0.99065551244753 2.10933438723929e-07 miRNAWalker2_validate -0.45834591686859 3.50571643482894e-18 NA NA NA hsa-miR-204-5p FZD1 0.537962150012098 0.0330895493358864 0.99065551244753 2.10933438723929e-07 miRNAWalker2_validate;miRTarBase -0.191287702204747 2.21232709468904e-07 NA NA NA hsa-miR-616-5p FZD1 -0.15056990463822 0.402836556304531 0.99065551244753 2.10933438723929e-07 mirMAP -0.158227006984694 0.00265078035674632 NA NA NA hsa-miR-107 FZD10 -0.241662461253454 0.0170788899505421 -1.18521144835282 0.000162683525329495 miRanda -0.685702388495361 6.84052605459746e-06 NA NA NA hsa-miR-15a-5p FZD10 -0.349521211668241 0.000770735998804807 -1.18521144835282 0.000162683525329495 miRNATAP -0.438409856444815 0.003263536270437 NA NA NA hsa-miR-455-3p FZD10 1.3998033821095 5.72010709806871e-17 -1.18521144835282 0.000162683525329495 PITA;miRNATAP -0.56334164531716 9.62780657403636e-11 NA NA NA hsa-miR-885-5p FZD10 0.940994379567568 0.00118729865914982 -1.18521144835282 0.000162683525329495 miRNATAP -0.13685072159518 0.00962492070890173 NA NA NA hsa-miR-616-5p FZD2 -0.15056990463822 0.402836556304531 -0.40720823353524 0.0755693801228694 MirTarget -0.338122672996804 3.93516371913571e-08 NA NA NA hsa-miR-107 FZD3 -0.241662461253454 0.0170788899505421 0.431602727356764 0.0760494397449049 MirTarget;miRanda -0.328401554754828 0.0054060803500497 NA NA NA hsa-miR-130b-3p FZD3 -0.687190305027545 0.000109068658562257 0.431602727356764 0.0760494397449049 mirMAP -0.223724254155923 0.000730162697139419 NA NA NA hsa-miR-148a-5p FZD3 0.767626696027764 1.08359477494785e-06 0.431602727356764 0.0760494397449049 mirMAP -0.211739463838664 0.00451119062120206 NA NA NA hsa-miR-17-5p FZD3 -0.698861147045456 2.43854106455432e-05 0.431602727356764 0.0760494397449049 MirTarget;TargetScan;mirMAP;miRNATAP -0.236272506444877 0.000871018931823823 NA NA NA hsa-miR-194-5p FZD3 0.29253016099247 0.099614138487652 0.431602727356764 0.0760494397449049 miRNATAP -0.163368946568916 0.0146280231481158 NA NA NA hsa-miR-19a-3p FZD3 -1.01712596153671 2.57753201450637e-07 0.431602727356764 0.0760494397449049 mirMAP -0.18311268282731 0.00197585182551426 NA NA NA hsa-miR-19b-3p FZD3 -0.601279551368823 0.000166850970852514 0.431602727356764 0.0760494397449049 mirMAP -0.24031433694887 0.00112634324256369 NA NA NA hsa-miR-20a-5p FZD3 -0.854326758726998 5.04256669663367e-07 0.431602727356764 0.0760494397449049 MirTarget;mirMAP;miRNATAP -0.263395197675831 0.000124585706310954 NA NA NA hsa-miR-23b-3p FZD3 0.530561587109029 5.43807206823475e-07 0.431602727356764 0.0760494397449049 MirTarget -0.264478922308601 0.0178497249104268 NA NA NA hsa-miR-30b-3p FZD3 0.439724365151374 0.000947180503583578 0.431602727356764 0.0760494397449049 MirTarget -0.24731920299484 0.00552723242526519 NA NA NA hsa-miR-30d-5p FZD3 -0.718283816348027 2.47422074061319e-08 0.431602727356764 0.0760494397449049 MirTarget;miRNATAP -0.251555607321146 0.00569090251961539 NA NA NA hsa-miR-30e-5p FZD3 0.627815042856664 3.02205690184776e-10 0.431602727356764 0.0760494397449049 MirTarget -0.313017658821363 0.00780190229296611 NA NA NA hsa-miR-3170 FZD3 0.490667754008914 0.0102869987033346 0.431602727356764 0.0760494397449049 MirTarget -0.129762933069345 0.0396673291425133 NA NA NA hsa-miR-32-3p FZD3 -0.219109440121582 0.207217051619542 0.431602727356764 0.0760494397449049 mirMAP -0.142320131411888 0.0444762815294513 NA NA NA hsa-miR-361-5p FZD3 -0.233202959858694 0.00961572812255393 0.431602727356764 0.0760494397449049 miRanda;miRNATAP -0.462237677798914 0.000503688852257815 NA NA NA hsa-miR-374a-3p FZD3 0.207171354826929 0.0623494608399903 0.431602727356764 0.0760494397449049 mirMAP -0.257601556493537 0.0167038211406134 NA NA NA hsa-miR-374a-5p FZD3 -0.0163903637472993 0.869784217438642 0.431602727356764 0.0760494397449049 mirMAP -0.515684566089532 1.54619533499017e-05 NA NA NA hsa-miR-374b-5p FZD3 0.307538028546427 0.00300796175459694 0.431602727356764 0.0760494397449049 mirMAP -0.314879611306133 0.00623855042899404 NA NA NA hsa-miR-618 FZD3 -0.13539895350352 0.517145913114103 0.431602727356764 0.0760494397449049 mirMAP -0.153943038668687 0.00893723937598839 NA NA NA hsa-let-7d-5p FZD4 -0.050329202012378 0.702580311853686 0.346477770504523 0.0109747315056818 MirTarget;miRNATAP -0.118288031351343 0.0198943536737446 NA NA NA hsa-miR-106b-5p FZD4 -0.648901865047096 8.24870862048014e-09 0.346477770504523 0.0109747315056818 miRNATAP -0.36533974993703 1.76820222419432e-10 NA NA NA hsa-miR-132-3p FZD4 -0.32379623969599 0.00272093067935146 0.346477770504523 0.0109747315056818 mirMAP -0.197762210860301 0.00135588231940112 NA NA NA hsa-miR-17-3p FZD4 -0.410352776142366 0.00422200500748652 0.346477770504523 0.0109747315056818 MirTarget -0.252002356659912 3.55104649644788e-08 NA NA NA hsa-miR-17-5p FZD4 -0.698861147045456 2.43854106455432e-05 0.346477770504523 0.0109747315056818 TargetScan -0.299061948789719 9.79518944458252e-15 NA NA NA hsa-miR-185-5p FZD4 -0.480006257154714 6.35758891340259e-07 0.346477770504523 0.0109747315056818 MirTarget -0.200083841875822 0.00363439169236857 NA NA NA hsa-miR-20a-5p FZD4 -0.854326758726998 5.04256669663367e-07 0.346477770504523 0.0109747315056818 miRNATAP -0.232364507622619 9.13182947842467e-10 NA NA NA hsa-miR-21-5p FZD4 -1.51084295924322 1.54551622173292e-34 0.346477770504523 0.0109747315056818 mirMAP -0.321725677881532 3.91700387140416e-11 NA NA NA hsa-miR-301a-3p FZD4 -0.84291051164036 1.43446467417895e-06 0.346477770504523 0.0109747315056818 mirMAP -0.250733852712318 8.69861743307876e-12 NA NA NA hsa-miR-3127-5p FZD4 -0.837385386388614 2.06679743975147e-07 0.346477770504523 0.0109747315056818 MirTarget -0.176968510712896 1.23416560759146e-05 NA NA NA hsa-miR-32-3p FZD4 -0.219109440121582 0.207217051619542 0.346477770504523 0.0109747315056818 mirMAP -0.121464026837635 0.00213277900393597 NA NA NA hsa-miR-32-5p FZD4 -0.0806126674663998 0.548984992497441 0.346477770504523 0.0109747315056818 mirMAP -0.154053517461878 0.00191026430922297 NA NA NA hsa-miR-324-3p FZD4 -0.260348469146492 0.0506141704203561 0.346477770504523 0.0109747315056818 miRNATAP -0.334268099452611 8.51422936858383e-12 NA NA NA hsa-miR-330-5p FZD4 -0.442231058604098 0.00533085608438092 0.346477770504523 0.0109747315056818 miRanda;miRNATAP -0.179393591072445 1.5890828802521e-05 NA NA NA hsa-miR-361-5p FZD4 -0.233202959858694 0.00961572812255393 0.346477770504523 0.0109747315056818 mirMAP -0.164186999309507 0.0280983856327006 NA NA NA hsa-miR-454-3p FZD4 -0.668749059573953 2.42670710515125e-06 0.346477770504523 0.0109747315056818 mirMAP -0.23311646427779 3.96330467330486e-07 NA NA NA hsa-miR-484 FZD4 -0.0857240033709612 0.453982056282252 0.346477770504523 0.0109747315056818 PITA -0.188977225347998 0.00122538887414835 NA NA NA hsa-miR-589-3p FZD4 -1.16846704028095 5.88525574424201e-11 0.346477770504523 0.0109747315056818 mirMAP -0.139392746188407 0.000169124779133096 NA NA NA hsa-miR-590-5p FZD4 0.103355559980407 0.310027295317082 0.346477770504523 0.0109747315056818 mirMAP -0.202339454029402 0.00215050890915688 NA NA NA hsa-miR-629-3p FZD4 0.315338123880353 0.119091248294945 0.346477770504523 0.0109747315056818 miRNATAP -0.180168798456347 6.64540825121219e-08 NA NA NA hsa-miR-92a-3p FZD4 -0.212391012518189 0.134292268090006 0.346477770504523 0.0109747315056818 mirMAP -0.269272307477207 6.07485388868062e-09 NA NA NA hsa-miR-940 FZD4 -0.453020092551483 0.0177054921651998 0.346477770504523 0.0109747315056818 miRNATAP -0.132263443170156 0.000207893541211134 NA NA NA hsa-miR-98-5p FZD4 0.0487189107419477 0.715911066732523 0.346477770504523 0.0109747315056818 MirTarget -0.103807475955208 0.0380444515679092 NA NA NA hsa-miR-155-5p FZD5 -0.0108524225071811 0.956513310335039 0.369296645507689 0.00193987461810236 miRNATAP -0.108901572202147 0.000190892447770734 NA NA NA hsa-miR-22-5p FZD5 0.630365901263173 3.32415348030402e-05 0.369296645507689 0.00193987461810236 mirMAP -0.135763345615629 0.000350175467115029 NA NA NA hsa-miR-23a-3p FZD5 0.178875974460576 0.1359782735406 0.369296645507689 0.00193987461810236 miRNATAP -0.221775183749934 4.71150652459033e-06 NA NA NA hsa-miR-342-3p FZD5 0.31967731498426 0.0449813878317159 0.369296645507689 0.00193987461810236 PITA -0.145780735296127 6.11633847456932e-05 NA NA NA hsa-miR-101-3p FZD6 1.48176407980989 3.9895070738552e-31 -0.589500198001939 0.00374127878510925 miRNAWalker2_validate;MirTarget -0.312670748498135 1.38907823475328e-05 NA NA NA hsa-miR-139-5p FZD6 2.11299531796557 8.16407076414796e-28 -0.589500198001939 0.00374127878510925 miRanda -0.171390807110702 0.00034847427750895 NA NA NA hsa-miR-194-5p FZD6 0.29253016099247 0.099614138487652 -0.589500198001939 0.00374127878510925 MirTarget -0.265420163621645 1.75074747054336e-06 NA NA NA hsa-miR-455-5p FZD6 0.270546034117159 0.0581320703577714 -0.589500198001939 0.00374127878510925 miRanda -0.230555626016252 0.000940179578305785 NA NA NA hsa-miR-130b-5p FZD7 -0.170599813152403 0.337611586432785 0.284533887049024 0.25655797853603 mirMAP -0.282002555419828 3.7625719536306e-05 NA NA NA hsa-miR-192-5p FZD7 0.50188499512787 0.00344713341196035 0.284533887049024 0.25655797853603 miRNAWalker2_validate -0.59446912784293 2.96084223842181e-18 NA NA NA hsa-miR-215-5p FZD7 0.981544773246516 3.14452272477116e-05 0.284533887049024 0.25655797853603 miRNAWalker2_validate -0.176488344117398 0.00056453629652869 NA NA NA hsa-miR-30c-1-3p FZD7 1.39373825444537 6.39912952911463e-17 0.284533887049024 0.25655797853603 MirTarget -0.242705306431575 0.000670205498648697 NA NA NA hsa-miR-33a-3p FZD7 0.683025859637737 1.01106097756419e-05 0.284533887049024 0.25655797853603 mirMAP;miRNATAP -0.17228797179382 0.0283762401460251 NA NA NA hsa-miR-486-5p FZD7 1.77766890600023 2.90717179299196e-14 0.284533887049024 0.25655797853603 miRanda -0.198992007637947 7.59438109490878e-05 NA NA NA hsa-miR-532-5p FZD7 -1.027295465106 9.93318913967036e-16 0.284533887049024 0.25655797853603 PITA;miRNATAP -0.194132922185613 0.0361734552526328 NA NA NA hsa-miR-616-5p FZD7 -0.15056990463822 0.402836556304531 0.284533887049024 0.25655797853603 mirMAP -0.181379407562843 0.00784556160013837 NA NA NA hsa-miR-362-3p FZD8 -0.814007335895912 2.00108618836575e-09 1.21039879054975 2.52210905797721e-08 miRanda -0.247656870244882 0.00149588487455642 NA NA NA hsa-miR-374b-5p FZD8 0.307538028546427 0.00300796175459694 1.21039879054975 2.52210905797721e-08 miRNAWalker2_validate -0.276231840355344 0.0082320939699218 NA NA NA hsa-miR-192-5p FZD9 0.50188499512787 0.00344713341196035 0.243785341556495 0.505341223526541 miRNATAP -0.306354280194544 0.00309846297489247 NA NA NA hsa-miR-491-5p FZD9 0.369122930844418 0.0154047757048929 0.243785341556495 0.505341223526541 miRanda -0.283236804570103 0.01668167503007 NA NA NA hsa-miR-29b-3p GSK3B 0.348885528720526 0.0121441341291263 -0.113142239705945 0.0774493616233047 miRTarBase;miRNATAP -0.106852381323571 1.32787261855633e-06 NA NA NA hsa-miR-342-3p GSK3B 0.31967731498426 0.0449813878317159 -0.113142239705945 0.0774493616233047 miRanda -0.106989468297279 2.44530655156687e-08 NA NA NA hsa-miR-501-5p JUN -1.15231083477882 2.98906150004095e-10 1.59869078760735 2.29997625217219e-23 MirTarget;PITA;miRNATAP -0.201525326742419 4.62918338980132e-06 NA NA NA hsa-miR-92a-3p JUN -0.212391012518189 0.134292268090006 1.59869078760735 2.29997625217219e-23 miRNATAP -0.217656471355875 0.000190729748454868 NA NA NA hsa-miR-93-5p JUN -1.39518349670952 2.84167728726739e-25 1.59869078760735 2.29997625217219e-23 miRNAWalker2_validate -0.346015058492204 1.41571654493278e-09 NA NA NA hsa-let-7a-3p LEF1 0.568717557554073 1.00947202557797e-07 -2.65801616612257 2.0774033860889e-15 miRNATAP -0.639538499404186 4.40051133869843e-05 NA NA NA hsa-let-7b-3p LEF1 1.21979213547786 5.84575581584582e-17 -2.65801616612257 2.0774033860889e-15 miRNATAP -0.67397556538713 8.7442482981614e-10 NA NA NA hsa-miR-193b-3p LEF1 0.166697207281751 0.272022543069474 -2.65801616612257 2.0774033860889e-15 miRNAWalker2_validate -0.526045563134031 2.1073127312606e-06 NA NA NA hsa-miR-217 LEF1 -1.0579729754038 0.0401026692682437 -2.65801616612257 2.0774033860889e-15 miRanda -0.105257516400941 0.00126797400951558 NA NA NA hsa-miR-26a-5p LEF1 0.963792031426847 1.83360999387309e-22 -2.65801616612257 2.0774033860889e-15 miRNATAP -0.92158550768103 1.12073884009285e-08 NA NA NA hsa-miR-26b-5p LEF1 1.10804856399745 4.14176110313907e-22 -2.65801616612257 2.0774033860889e-15 miRNATAP -0.884181051978605 1.54988692872715e-10 24785257 miR26b is downregulated in several cancers and tumors and miR26b directly targets the lymphoid enhancer factor 1 Lef13'UTR and inhibits endogenous Lef1 expression; We report that miR26b expression is associated with human colon cancer through the regulation of LEF1 expression in colon cancer cells; Analyses of multiple colon cancer cell lines revealed an inverse correlation between miR26b and LEF1 expression; Normal human colon cells express low levels of LEF1 and high levels of miR26b; however human colon cancer cells have decreased miR26b expression and increased LEF1 expression; We demonstrate that miR26b expression is a potent inhibitor of colon cancer cell proliferation and significantly decreases LEF1 expression; Analyses of human colon cancer databases also demonstrated a link between miR26b and LEF1 expression colon cancer hsa-miR-3065-3p LEF1 1.04244468016704 4.60743424372591e-05 -2.65801616612257 2.0774033860889e-15 miRNATAP -0.274446867079685 2.50754901313177e-05 NA NA NA hsa-miR-320b LEF1 -0.0919652022571327 0.607981643616947 -2.65801616612257 2.0774033860889e-15 miRanda;mirMAP -0.19850093759544 0.0373018142195917 NA NA NA hsa-miR-326 LEF1 1.881935132554 1.68087316863775e-21 -2.65801616612257 2.0774033860889e-15 miRanda -0.385522349171234 2.19966753424773e-06 NA NA NA hsa-miR-335-3p LEF1 0.275199247483114 0.10662916524878 -2.65801616612257 2.0774033860889e-15 mirMAP -0.250697485301874 0.0116970760668734 NA NA NA hsa-miR-33a-3p LEF1 0.683025859637737 1.01106097756419e-05 -2.65801616612257 2.0774033860889e-15 miRNATAP -0.438284453346108 5.04525548190065e-05 NA NA NA hsa-miR-455-5p LEF1 0.270546034117159 0.0581320703577714 -2.65801616612257 2.0774033860889e-15 miRanda -0.352774280915771 0.00297563964985378 NA NA NA hsa-miR-590-3p LEF1 0.47316749804781 1.76652934637215e-05 -2.65801616612257 2.0774033860889e-15 PITA;miRanda;mirMAP -0.434383824253157 0.00459273011390873 NA NA NA hsa-miR-7-1-3p LEF1 0.569105143287802 1.85297665041411e-05 -2.65801616612257 2.0774033860889e-15 mirMAP -0.451164571544049 0.000354486807433584 NA NA NA hsa-miR-23a-3p LRP5 0.178875974460576 0.1359782735406 0.425686510899651 0.000372958337957885 MirTarget -0.166260660405269 0.000692486268247638 NA NA NA hsa-miR-15a-5p LRP6 -0.349521211668241 0.000770735998804807 0.374410866893443 0.00134878645388482 miRNATAP -0.161392611628997 0.00341573687442505 NA NA NA hsa-miR-181a-5p LRP6 -0.25011343590295 0.0551933249319328 0.374410866893443 0.00134878645388482 mirMAP -0.131385397631165 0.00276797465432674 NA NA NA hsa-miR-181b-5p LRP6 -0.488256489401109 0.00105321129419699 0.374410866893443 0.00134878645388482 mirMAP -0.118078225864745 0.00198310355409659 NA NA NA hsa-miR-181c-5p LRP6 0.00639394152050299 0.969127212255928 0.374410866893443 0.00134878645388482 mirMAP -0.150359442458667 1.25914687198157e-05 NA NA NA hsa-miR-221-3p LRP6 -1.12244756358612 3.48370308238065e-13 0.374410866893443 0.00134878645388482 miRNAWalker2_validate -0.100566445726281 0.00520193003801261 NA NA NA hsa-miR-29b-3p LRP6 0.348885528720526 0.0121441341291263 0.374410866893443 0.00134878645388482 miRNATAP -0.181222286803993 8.93829726850804e-06 NA NA NA hsa-miR-500a-5p LRP6 -0.797906382969155 9.1595817108425e-08 0.374410866893443 0.00134878645388482 mirMAP -0.134394284724872 0.000354573936852958 NA NA NA hsa-miR-501-5p LRP6 -1.15231083477882 2.98906150004095e-10 0.374410866893443 0.00134878645388482 PITA;miRNATAP -0.132673220942642 1.26106097947001e-05 NA NA NA hsa-miR-532-5p LRP6 -1.027295465106 9.93318913967036e-16 0.374410866893443 0.00134878645388482 miRNATAP -0.119982431542834 0.00549501464978995 NA NA NA hsa-miR-582-5p LRP6 0.680189083316822 0.00103755166534107 0.374410866893443 0.00134878645388482 PITA;miRNATAP -0.101851033298752 0.000201464099298574 NA NA NA hsa-miR-590-5p LRP6 0.103355559980407 0.310027295317082 0.374410866893443 0.00134878645388482 PITA;miRanda;miRNATAP -0.135202405805955 0.0172101237371024 NA NA NA hsa-miR-671-5p LRP6 -0.843645373345786 3.92794196273325e-08 0.374410866893443 0.00134878645388482 PITA -0.147393432405413 5.43555722219698e-05 NA NA NA hsa-miR-93-5p LRP6 -1.39518349670952 2.84167728726739e-25 0.374410866893443 0.00134878645388482 mirMAP -0.140329700452744 0.00045179848594501 NA NA NA hsa-miR-30d-3p MAP3K7 0.120562286038761 0.32954953478212 -0.0227052645956194 0.800739743576661 MirTarget -0.152801707733114 1.47792797573938e-05 NA NA NA hsa-miR-130b-3p MAPK10 -0.687190305027545 0.000109068658562257 1.09210524801043 3.20431274629699e-05 miRNATAP -0.246373643413876 0.000632339067040355 NA NA NA hsa-miR-146b-5p MAPK10 -0.41971954679544 0.0457375823220201 1.09210524801043 3.20431274629699e-05 miRanda -0.252372073662625 3.58793936262133e-05 NA NA NA hsa-miR-19a-3p MAPK10 -1.01712596153671 2.57753201450637e-07 1.09210524801043 3.20431274629699e-05 miRNATAP -0.168630672973342 0.00898420702556428 NA NA NA hsa-miR-19b-3p MAPK10 -0.601279551368823 0.000166850970852514 1.09210524801043 3.20431274629699e-05 miRNATAP -0.202245351611927 0.0120351860236733 NA NA NA hsa-miR-221-3p MAPK10 -1.12244756358612 3.48370308238065e-13 1.09210524801043 3.20431274629699e-05 miRNATAP -0.345546531666561 1.95748420882985e-05 NA NA NA hsa-miR-222-3p MAPK10 -1.08574156066353 1.76407192348154e-11 1.09210524801043 3.20431274629699e-05 miRNATAP -0.215253828844877 0.00588066987412212 NA NA NA hsa-miR-454-3p MAPK10 -0.668749059573953 2.42670710515125e-06 1.09210524801043 3.20431274629699e-05 miRNATAP -0.19018890919728 0.0355512111583229 NA NA NA hsa-miR-455-5p MAPK10 0.270546034117159 0.0581320703577714 1.09210524801043 3.20431274629699e-05 miRanda -0.235174401855498 0.00956735979323835 NA NA NA hsa-miR-590-5p MAPK10 0.103355559980407 0.310027295317082 1.09210524801043 3.20431274629699e-05 PITA;miRanda;miRNATAP -0.3693102549963 0.00397298728893767 NA NA NA hsa-miR-30b-5p MAPK8 0.540561867086174 2.44688760798314e-05 0.855423391564127 4.38860774117181e-05 mirMAP -0.211224878227047 0.0083058660521866 NA NA NA hsa-miR-30d-5p MAPK8 -0.718283816348027 2.47422074061319e-08 0.855423391564127 4.38860774117181e-05 mirMAP -0.215078369558139 0.00642208423108097 NA NA NA hsa-miR-140-5p MAPK9 0.220106443070148 0.0140713197101226 -0.233788075084069 0.00112433159060851 miRanda -0.130430637695707 0.000917008693159836 NA NA NA hsa-miR-590-3p MAPK9 0.47316749804781 1.76652934637215e-05 -0.233788075084069 0.00112433159060851 miRanda;mirMAP -0.101280114384897 0.00134322482300103 NA NA NA hsa-miR-455-5p MMP7 0.270546034117159 0.0581320703577714 2.01551939575685 0.000378454690134259 miRanda -0.544946507919829 0.00528291990396599 NA NA NA hsa-miR-20a-5p MYC -0.854326758726998 5.04256669663367e-07 1.53204423111148 3.53987625613015e-10 miRNAWalker2_validate -0.165031814042356 0.0197576054298013 26012475 Finally miR-20a abrogated the TGF-β-mediated c-Myc repression a direct inhibitor of the CDKN1A promoter activation most likely by reducing the expression of specific MYC-regulating genes from the Smad/E2F-based core repressor complex colon cancer hsa-miR-423-5p MYC -0.698807775906483 1.02195196334629e-11 1.53204423111148 3.53987625613015e-10 miRNAWalker2_validate -0.328206409340035 0.00484551582134482 NA NA NA hsa-miR-107 NFAT5 -0.241662461253454 0.0170788899505421 0.326144498869476 0.00164314559569314 MirTarget -0.115722218242209 0.0216894104295148 NA NA NA hsa-miR-148b-3p NFAT5 -0.266862251671907 0.00185271302045965 0.326144498869476 0.00164314559569314 miRNATAP -0.209618507772718 0.000426872096110993 NA NA NA hsa-miR-17-3p NFAT5 -0.410352776142366 0.00422200500748652 0.326144498869476 0.00164314559569314 mirMAP -0.104599542268839 0.00299701612631111 NA NA NA hsa-miR-192-3p NFAT5 0.640116511400704 0.000266272092403793 0.326144498869476 0.00164314559569314 MirTarget;miRNATAP -0.128669502769738 6.06524882230981e-06 NA NA NA hsa-miR-193a-3p NFAT5 0.117675551589899 0.309391958208565 0.326144498869476 0.00164314559569314 miRanda -0.164695361244703 0.00017397882324283 NA NA NA hsa-miR-194-3p NFAT5 0.772747277805345 2.95374651701899e-05 0.326144498869476 0.00164314559569314 miRNATAP -0.111726483279078 3.42120115644121e-05 NA NA NA hsa-miR-194-5p NFAT5 0.29253016099247 0.099614138487652 0.326144498869476 0.00164314559569314 miRNATAP -0.121386239180467 1.81500128575235e-05 NA NA NA hsa-miR-21-5p NFAT5 -1.51084295924322 1.54551622173292e-34 0.326144498869476 0.00164314559569314 miRNAWalker2_validate;mirMAP -0.110763353790018 0.00341649802767152 NA NA NA hsa-miR-30d-5p NFAT5 -0.718283816348027 2.47422074061319e-08 0.326144498869476 0.00164314559569314 MirTarget;miRNATAP -0.100982909052041 0.00926486855231398 NA NA NA hsa-miR-362-5p NFAT5 -0.717921690799307 1.68392734504546e-05 0.326144498869476 0.00164314559569314 mirMAP -0.104218483552879 0.000512788061950843 NA NA NA hsa-miR-548j-5p NFAT5 -0.251239647701947 0.171361975450223 0.326144498869476 0.00164314559569314 MirTarget -0.114891906111678 4.99601526011913e-05 NA NA NA hsa-miR-885-5p NFAT5 0.940994379567568 0.00118729865914982 0.326144498869476 0.00164314559569314 PITA -0.136348025989459 3.53390243312021e-16 NA NA NA hsa-miR-421 NFATC1 -0.94185633469408 6.12167297054091e-08 0.746396319507339 4.35096501526623e-05 miRanda -0.107467159484021 0.0355691075947507 NA NA NA hsa-miR-455-5p NFATC1 0.270546034117159 0.0581320703577714 0.746396319507339 4.35096501526623e-05 miRanda -0.308343970820935 7.69222772176338e-07 NA NA NA hsa-miR-29a-5p NFATC2 0.113555908626947 0.349622266470784 1.87041062792181 1.43414339850835e-07 mirMAP;miRNATAP -0.583625441866098 5.86022160251471e-05 NA NA NA hsa-miR-30d-5p NFATC2 -0.718283816348027 2.47422074061319e-08 1.87041062792181 1.43414339850835e-07 MirTarget;mirMAP -0.429558488883224 0.00143308759494954 NA NA NA hsa-miR-15a-5p NFATC3 -0.349521211668241 0.000770735998804807 0.644444487566839 5.42635056668795e-13 MirTarget;miRNATAP -0.140535010330653 0.0011067840013694 NA NA NA hsa-miR-185-5p NFATC3 -0.480006257154714 6.35758891340259e-07 0.644444487566839 5.42635056668795e-13 MirTarget;miRNATAP -0.179084861620697 0.000100696521869942 NA NA NA hsa-miR-222-3p NFATC3 -1.08574156066353 1.76407192348154e-11 0.644444487566839 5.42635056668795e-13 MirTarget;miRNATAP -0.132741702448246 6.9873783779618e-07 NA NA NA hsa-miR-30d-5p NFATC3 -0.718283816348027 2.47422074061319e-08 0.644444487566839 5.42635056668795e-13 MirTarget;miRNATAP -0.107813608303496 0.00162247650109074 NA NA NA hsa-miR-324-3p NFATC3 -0.260348469146492 0.0506141704203561 0.644444487566839 5.42635056668795e-13 miRNAWalker2_validate -0.114816122875489 0.000628244289295564 NA NA NA hsa-miR-335-3p NFATC3 0.275199247483114 0.10662916524878 0.644444487566839 5.42635056668795e-13 mirMAP -0.129711946659763 5.8123470467313e-07 NA NA NA hsa-miR-339-5p NFATC3 -0.28058991987842 0.0355660282647232 0.644444487566839 5.42635056668795e-13 miRanda -0.169042767427976 3.57074145767803e-07 NA NA NA hsa-miR-361-3p NFATC3 -0.275658012727112 0.00549374744374472 0.644444487566839 5.42635056668795e-13 miRNAWalker2_validate -0.115563777799957 0.0108582893463889 NA NA NA hsa-miR-361-5p NFATC3 -0.233202959858694 0.00961572812255393 0.644444487566839 5.42635056668795e-13 miRanda -0.107258381563901 0.0328186270836467 NA NA NA hsa-miR-362-3p NFATC3 -0.814007335895912 2.00108618836575e-09 0.644444487566839 5.42635056668795e-13 miRanda -0.165414246315846 2.41507380316181e-07 NA NA NA hsa-miR-589-3p NFATC3 -1.16846704028095 5.88525574424201e-11 0.644444487566839 5.42635056668795e-13 mirMAP -0.152120593205245 5.77499693309063e-10 NA NA NA hsa-miR-125b-5p NFATC4 1.35767721102906 1.1656461739517e-18 -0.864010892322999 1.90169048902367e-05 mirMAP -0.224809010069414 0.000268845801695449 NA NA NA hsa-miR-130b-5p NFATC4 -0.170599813152403 0.337611586432785 -0.864010892322999 1.90169048902367e-05 mirMAP -0.223334355722899 6.08007516287365e-05 NA NA NA hsa-miR-29a-3p NFATC4 0.856762511178141 4.65330336378316e-12 -0.864010892322999 1.90169048902367e-05 miRNATAP -0.210278806007119 0.00743486328282441 NA NA NA hsa-miR-29c-3p NFATC4 1.4367517608807 1.61767774905732e-21 -0.864010892322999 1.90169048902367e-05 miRNATAP -0.144412784703952 0.0215414373459198 NA NA NA hsa-miR-3607-3p NFATC4 2.15518588554494 1.03390728226714e-23 -0.864010892322999 1.90169048902367e-05 miRNATAP -0.174472801573825 6.00001387189594e-05 NA NA NA hsa-miR-200b-3p NKD1 1.29335788099229 0.000268623234305043 -0.620599204750343 0.186026311634854 TargetScan -0.177575800556816 0.00545052296927983 NA NA NA hsa-miR-24-3p NKD1 0.257825594021959 0.00689742600215214 -0.620599204750343 0.186026311634854 miRNAWalker2_validate -0.720087685375527 0.00289253594101155 NA NA NA hsa-miR-326 NKD1 1.881935132554 1.68087316863775e-21 -0.620599204750343 0.186026311634854 miRanda -0.457719741066059 3.39632756723267e-05 NA NA NA hsa-miR-330-5p NKD1 -0.442231058604098 0.00533085608438092 -0.620599204750343 0.186026311634854 miRanda;miRNATAP -0.798011342105715 1.8924968824333e-08 NA NA NA hsa-miR-340-5p NKD1 0.0047761453138202 0.968502722773762 -0.620599204750343 0.186026311634854 mirMAP -0.497913166437519 0.00902117405267133 NA NA NA hsa-miR-429 NKD1 1.40262535827284 6.93982219171929e-05 -0.620599204750343 0.186026311634854 miRanda;miRNATAP -0.15370546627733 0.0183778285386797 NA NA NA hsa-miR-501-5p NKD1 -1.15231083477882 2.98906150004095e-10 -0.620599204750343 0.186026311634854 mirMAP -0.34471849546258 0.00491783464284498 NA NA NA hsa-let-7g-5p NLK 0.461294133285531 2.17210114729869e-05 -0.221348006067538 0.00116385654486998 miRNATAP -0.101066887340294 0.000890681375267317 NA NA NA hsa-let-7i-5p NLK 0.142679361652131 0.154141689875845 -0.221348006067538 0.00116385654486998 miRNATAP -0.158130621990857 1.85250015482722e-06 NA NA NA hsa-miR-132-3p NLK -0.32379623969599 0.00272093067935146 -0.221348006067538 0.00116385654486998 miRNATAP -0.128638110704715 2.68599518720146e-05 NA NA NA hsa-miR-140-5p NLK 0.220106443070148 0.0140713197101226 -0.221348006067538 0.00116385654486998 MirTarget;PITA;miRanda;miRNATAP -0.103530034440285 0.00564970191186252 NA NA NA hsa-miR-23a-3p NLK 0.178875974460576 0.1359782735406 -0.221348006067538 0.00116385654486998 miRNAWalker2_validate;MirTarget -0.179303032195093 4.45306067895512e-11 NA NA NA hsa-miR-27a-3p NLK 0.37080738041511 0.00875721956202742 -0.221348006067538 0.00116385654486998 miRNATAP -0.148898136450612 9.12948651604776e-11 NA NA NA hsa-miR-511-5p NLK 1.75067415533113 3.37801163573303e-23 -0.221348006067538 0.00116385654486998 MirTarget -0.104612392627311 2.15162536528134e-09 NA NA NA hsa-miR-542-3p NLK 1.31351015149842 3.64642423288513e-22 -0.221348006067538 0.00116385654486998 miRanda;miRNATAP -0.139301025800919 1.05822598358559e-09 NA NA NA hsa-let-7g-3p PLCB1 1.14091000722297 8.3273601818868e-19 -1.21243658346715 1.07604080006657e-07 miRNATAP -0.378100618457424 6.07423095960529e-06 NA NA NA hsa-miR-125b-5p PLCB1 1.35767721102906 1.1656461739517e-18 -1.21243658346715 1.07604080006657e-07 miRNATAP -0.431815972266254 3.97695185275028e-10 NA NA NA hsa-miR-130a-3p PLCB1 1.53229181736223 2.91460363624832e-19 -1.21243658346715 1.07604080006657e-07 miRNATAP -0.146247750829386 0.020940675156694 NA NA NA hsa-miR-139-5p PLCB1 2.11299531796557 8.16407076414796e-28 -1.21243658346715 1.07604080006657e-07 miRanda -0.443285019092489 3.47497230555386e-17 NA NA NA hsa-miR-195-3p PLCB1 1.09375690196245 4.70092324819816e-09 -1.21243658346715 1.07604080006657e-07 mirMAP -0.183666338639752 0.00225143769000378 NA NA NA hsa-miR-34a-5p PLCB1 -1.03694231790864 5.7486401954075e-14 -1.21243658346715 1.07604080006657e-07 miRNATAP -0.202032428233518 0.0111678174466371 NA NA NA hsa-miR-16-2-3p PLCB4 0.0336420826463728 0.805158952566961 -0.840422266473221 0.000567827430148369 mirMAP -0.20139020815362 0.022512690153697 NA NA NA hsa-miR-192-3p PLCB4 0.640116511400704 0.000266272092403793 -0.840422266473221 0.000567827430148369 miRNATAP -0.557224111035552 1.21106381609851e-17 NA NA NA hsa-miR-26b-5p PLCB4 1.10804856399745 4.14176110313907e-22 -0.840422266473221 0.000567827430148369 miRNAWalker2_validate -0.216065937883519 0.0302269607574374 NA NA NA hsa-miR-361-5p PLCB4 -0.233202959858694 0.00961572812255393 -0.840422266473221 0.000567827430148369 miRanda -0.316455182216094 0.0185460711254101 NA NA NA hsa-miR-374a-5p PLCB4 -0.0163903637472993 0.869784217438642 -0.840422266473221 0.000567827430148369 mirMAP -0.40455507564767 0.00080732431795289 NA NA NA hsa-miR-374b-5p PLCB4 0.307538028546427 0.00300796175459694 -0.840422266473221 0.000567827430148369 mirMAP -0.47357360986951 4.03508572714821e-05 NA NA NA hsa-miR-590-3p PLCB4 0.47316749804781 1.76652934637215e-05 -0.840422266473221 0.000567827430148369 miRanda -0.405740740578056 0.000168632145756444 NA NA NA hsa-miR-455-5p PORCN 0.270546034117159 0.0581320703577714 -1.02534714775069 3.36165614457392e-14 miRanda -0.173425149892979 0.000268476293553168 NA NA NA hsa-miR-542-3p PORCN 1.31351015149842 3.64642423288513e-22 -1.02534714775069 3.36165614457392e-14 miRNATAP -0.129508237210699 0.00661906392499696 NA NA NA hsa-miR-148a-3p PPARD 0.748702855597006 3.93313343865502e-07 -0.42945286771637 0.000219062523065938 mirMAP -0.204207537151173 5.78289748261195e-08 NA NA NA hsa-miR-29a-3p PPARD 0.856762511178141 4.65330336378316e-12 -0.42945286771637 0.000219062523065938 miRNATAP -0.134258784924348 0.00280195950147314 NA NA NA hsa-miR-29c-3p PPARD 1.4367517608807 1.61767774905732e-21 -0.42945286771637 0.000219062523065938 miRNATAP -0.122368442661711 0.00063748151355122 NA NA NA hsa-miR-421 PPP2CB -0.94185633469408 6.12167297054091e-08 0.890331286940368 2.58768297455122e-18 miRNAWalker2_validate;miRanda -0.107091673318932 0.000264470518633695 NA NA NA hsa-miR-425-5p PPP2CB -0.585974239943861 2.23063410931427e-05 0.890331286940368 2.58768297455122e-18 miRNAWalker2_validate -0.210079108287547 1.06195847865028e-08 NA NA NA hsa-miR-940 PPP2CB -0.453020092551483 0.0177054921651998 0.890331286940368 2.58768297455122e-18 MirTarget;PITA -0.108413768942713 9.39010367602326e-05 NA NA NA hsa-miR-16-5p PPP2R1A 0.39857723517961 0.000101598495180161 -0.434617655824208 2.19736728816006e-07 miRNAWalker2_validate -0.16156782548915 5.72423585631049e-05 NA NA NA hsa-miR-505-5p PPP2R1A 0.768282569967004 1.14662846595398e-05 -0.434617655824208 2.19736728816006e-07 miRNAWalker2_validate -0.101132276982143 1.32519884220096e-05 NA NA NA hsa-miR-15a-5p PPP2R1B -0.349521211668241 0.000770735998804807 0.3663732792689 0.0120240053013943 MirTarget -0.149129894906409 0.0304654709530036 NA NA NA hsa-miR-15b-5p PPP2R1B -0.23056694141356 0.0824765001857524 0.3663732792689 0.0120240053013943 MirTarget -0.166547119923006 0.0019576167364681 NA NA NA hsa-miR-30b-5p PPP2R1B 0.540561867086174 2.44688760798314e-05 0.3663732792689 0.0120240053013943 miRNATAP -0.174282215186143 0.00161533222972509 NA NA NA hsa-miR-30d-3p PPP2R1B 0.120562286038761 0.32954953478212 0.3663732792689 0.0120240053013943 mirMAP -0.172420555072298 0.00291249897697552 NA NA NA hsa-miR-30d-5p PPP2R1B -0.718283816348027 2.47422074061319e-08 0.3663732792689 0.0120240053013943 miRNATAP -0.122684938544671 0.0248523471709719 NA NA NA hsa-miR-330-3p PPP2R1B 0.332364259424489 0.0316051913061457 0.3663732792689 0.0120240053013943 mirMAP -0.117464840218715 0.0128019984692913 NA NA NA hsa-miR-423-3p PPP2R1B -0.302157659154352 0.000669907339064866 0.3663732792689 0.0120240053013943 miRNAWalker2_validate -0.175790608241052 0.0299905282650269 NA NA NA hsa-miR-744-3p PPP2R1B 0.866026958622848 2.43034431433785e-08 0.3663732792689 0.0120240053013943 MirTarget -0.151341218126979 0.000790301774844116 NA NA NA hsa-miR-197-3p PPP2R5A 0.245033899783733 0.0362223947695163 -0.367967554039324 0.000201292409757374 MirTarget -0.159858222331069 0.000114867261240145 NA NA NA hsa-miR-335-5p PPP2R5A 1.61347836513558 1.62757083289686e-19 -0.367967554039324 0.000201292409757374 miRNAWalker2_validate -0.129221734799289 4.65625737104185e-07 NA NA NA hsa-miR-484 PPP2R5A -0.0857240033709612 0.453982056282252 -0.367967554039324 0.000201292409757374 miRNAWalker2_validate -0.142511519099843 0.000814298781875799 NA NA NA hsa-miR-582-5p PPP2R5A 0.680189083316822 0.00103755166534107 -0.367967554039324 0.000201292409757374 PITA;miRNATAP -0.15503416694514 1.05133889416276e-11 NA NA NA hsa-miR-590-3p PPP2R5A 0.47316749804781 1.76652934637215e-05 -0.367967554039324 0.000201292409757374 miRNAWalker2_validate -0.160887720851343 0.000232546271981156 NA NA NA hsa-miR-132-3p PPP2R5C -0.32379623969599 0.00272093067935146 0.197681049931811 0.00357159893729593 miRNATAP -0.13851439885365 5.20803505364117e-06 NA NA NA hsa-miR-1976 PPP2R5D 0.431472440543166 0.00324575010550949 -0.490236074781637 1.12387325087849e-09 MirTarget;miRNATAP -0.112669007651945 3.03261127309582e-05 NA NA NA hsa-miR-146b-5p PPP2R5E -0.41971954679544 0.0457375823220201 0.33926942209527 0.000598805950355039 miRanda -0.106437767995404 2.95231299168685e-06 NA NA NA hsa-miR-19b-3p PPP2R5E -0.601279551368823 0.000166850970852514 0.33926942209527 0.000598805950355039 miRTarBase;MirTarget -0.105521131212065 0.000437479384635745 NA NA NA hsa-miR-30d-3p PPP2R5E 0.120562286038761 0.32954953478212 0.33926942209527 0.000598805950355039 MirTarget -0.120884932247343 0.0020877492288168 NA NA NA hsa-miR-30d-5p PPP2R5E -0.718283816348027 2.47422074061319e-08 0.33926942209527 0.000598805950355039 mirMAP -0.112901581761164 0.00227875690176072 NA NA NA hsa-miR-455-5p PPP2R5E 0.270546034117159 0.0581320703577714 0.33926942209527 0.000598805950355039 miRanda -0.122888449602669 0.000278155025334759 NA NA NA hsa-miR-106b-5p PPP3CA -0.648901865047096 8.24870862048014e-09 0.536165287387851 2.77787023947602e-11 miRNATAP -0.191067063648852 3.69747843513626e-08 NA NA NA hsa-miR-17-3p PPP3CA -0.410352776142366 0.00422200500748652 0.536165287387851 2.77787023947602e-11 MirTarget -0.148715997251777 6.8452735631761e-08 NA NA NA hsa-miR-17-5p PPP3CA -0.698861147045456 2.43854106455432e-05 0.536165287387851 2.77787023947602e-11 miRNATAP -0.143640408234319 1.13035407609444e-09 NA NA NA hsa-miR-20a-5p PPP3CA -0.854326758726998 5.04256669663367e-07 0.536165287387851 2.77787023947602e-11 miRNATAP -0.13596145796804 2.84983869383186e-09 NA NA NA hsa-miR-21-5p PPP3CA -1.51084295924322 1.54551622173292e-34 0.536165287387851 2.77787023947602e-11 miRNATAP -0.143821297395015 1.2695170248385e-06 NA NA NA hsa-miR-30d-5p PPP3CA -0.718283816348027 2.47422074061319e-08 0.536165287387851 2.77787023947602e-11 miRNATAP -0.146138892286555 1.56191209956503e-06 NA NA NA hsa-miR-361-5p PPP3CA -0.233202959858694 0.00961572812255393 0.536165287387851 2.77787023947602e-11 miRanda -0.145335005010698 0.00120607782460008 NA NA NA hsa-miR-501-3p PPP3CA -0.999540908940091 2.77358485582016e-11 0.536165287387851 2.77787023947602e-11 MirTarget;PITA;miRNATAP -0.169069809996199 3.5765991379194e-11 NA NA NA hsa-miR-502-3p PPP3CA -0.659598854007547 3.01316453996411e-08 0.536165287387851 2.77787023947602e-11 MirTarget;PITA;miRNATAP -0.21026132041502 1.15384439121552e-10 NA NA NA hsa-miR-589-3p PPP3CA -1.16846704028095 5.88525574424201e-11 0.536165287387851 2.77787023947602e-11 MirTarget -0.121264895830011 4.18270966031286e-08 NA NA NA hsa-miR-93-3p PPP3CA -0.40282112910759 0.00131324842735598 0.536165287387851 2.77787023947602e-11 miRNATAP -0.143288165599429 6.27730698290466e-06 NA NA NA hsa-miR-93-5p PPP3CA -1.39518349670952 2.84167728726739e-25 0.536165287387851 2.77787023947602e-11 miRNATAP -0.206462809599041 4.19505348801646e-14 NA NA NA hsa-miR-361-5p PPP3CC -0.233202959858694 0.00961572812255393 0.442598423475552 4.06646193924098e-07 miRanda -0.159719077024821 0.00091909551904825 NA NA NA hsa-miR-106b-5p PPP3R1 -0.648901865047096 8.24870862048014e-09 0.348267739030593 8.30932335829679e-08 MirTarget;miRNATAP -0.138661227962938 5.82082557526804e-07 NA NA NA hsa-miR-181a-5p PPP3R1 -0.25011343590295 0.0551933249319328 0.348267739030593 8.30932335829679e-08 MirTarget;miRNATAP -0.13691462952235 1.55708164198961e-08 NA NA NA hsa-miR-181b-5p PPP3R1 -0.488256489401109 0.00105321129419699 0.348267739030593 8.30932335829679e-08 MirTarget;miRNATAP -0.13726473522507 5.36198845965272e-11 NA NA NA hsa-miR-181c-5p PPP3R1 0.00639394152050299 0.969127212255928 0.348267739030593 8.30932335829679e-08 MirTarget;miRNATAP -0.116625763794141 9.00795108119744e-10 NA NA NA hsa-miR-24-3p PPP3R1 0.257825594021959 0.00689742600215214 0.348267739030593 8.30932335829679e-08 miRNAWalker2_validate -0.106343408108425 0.00160055709787487 NA NA NA hsa-miR-27a-3p PPP3R1 0.37080738041511 0.00875721956202742 0.348267739030593 8.30932335829679e-08 miRNATAP -0.117734120643401 1.31409589262749e-07 NA NA NA hsa-miR-93-5p PPP3R1 -1.39518349670952 2.84167728726739e-25 0.348267739030593 8.30932335829679e-08 MirTarget;miRNATAP -0.108796059262154 9.63915967695639e-07 NA NA NA hsa-miR-17-5p PRICKLE1 -0.698861147045456 2.43854106455432e-05 1.74028095832004 2.56191738876966e-10 miRNAWalker2_validate -0.471288188738112 5.85304220563611e-09 NA NA NA hsa-miR-192-5p PRICKLE1 0.50188499512787 0.00344713341196035 1.74028095832004 2.56191738876966e-10 miRNAWalker2_validate -0.647920508976856 3.38291204645263e-17 NA NA NA hsa-miR-30d-5p PRICKLE1 -0.718283816348027 2.47422074061319e-08 1.74028095832004 2.56191738876966e-10 miRNATAP -0.212861909433595 0.0434894861524089 NA NA NA hsa-miR-361-5p PRICKLE1 -0.233202959858694 0.00961572812255393 1.74028095832004 2.56191738876966e-10 miRanda -0.911449762777299 1.77245863720157e-09 NA NA NA hsa-miR-532-5p PRICKLE1 -1.027295465106 9.93318913967036e-16 1.74028095832004 2.56191738876966e-10 miRNATAP -0.715708313801668 1.59405526679308e-12 NA NA NA hsa-miR-10b-3p PRICKLE2 -2.77189254628215 2.26687582932635e-20 1.36375835552812 1.67599789165391e-08 mirMAP -0.177808417675403 1.35390355995124e-05 NA NA NA hsa-miR-130b-5p PRICKLE2 -0.170599813152403 0.337611586432785 1.36375835552812 1.67599789165391e-08 mirMAP -0.187298096946198 0.00553641611764345 NA NA NA hsa-miR-148a-3p PRICKLE2 0.748702855597006 3.93313343865502e-07 1.36375835552812 1.67599789165391e-08 MirTarget;miRNATAP -0.361824889511995 5.66694348602003e-06 NA NA NA hsa-miR-148a-5p PRICKLE2 0.767626696027764 1.08359477494785e-06 1.36375835552812 1.67599789165391e-08 mirMAP -0.346057768362087 3.65630739339723e-06 NA NA NA hsa-miR-148b-3p PRICKLE2 -0.266862251671907 0.00185271302045965 1.36375835552812 1.67599789165391e-08 MirTarget;miRNATAP -0.463580487018835 0.00102384966132943 NA NA NA hsa-miR-194-5p PRICKLE2 0.29253016099247 0.099614138487652 1.36375835552812 1.67599789165391e-08 miRNATAP -0.255884515251328 0.000142668537041326 NA NA NA hsa-miR-21-5p PRICKLE2 -1.51084295924322 1.54551622173292e-34 1.36375835552812 1.67599789165391e-08 miRNAWalker2_validate;MirTarget -0.234850115033432 0.00889222361721155 NA NA NA hsa-miR-224-3p PRICKLE2 -1.40770116795301 1.31426607144612e-08 1.36375835552812 1.67599789165391e-08 mirMAP -0.194235568747061 5.0034200553647e-05 NA NA NA hsa-miR-374a-3p PRICKLE2 0.207171354826929 0.0623494608399903 1.36375835552812 1.67599789165391e-08 MirTarget;miRNATAP -0.268372531764719 0.0135953973446289 NA NA NA hsa-miR-589-5p PRICKLE2 -1.18593770505086 1.01781241960567e-22 1.36375835552812 1.67599789165391e-08 MirTarget;miRNATAP -0.537211352042197 7.52017218056411e-09 NA NA NA hsa-miR-616-5p PRICKLE2 -0.15056990463822 0.402836556304531 1.36375835552812 1.67599789165391e-08 mirMAP -0.271020972646323 4.67751140057223e-05 NA NA NA hsa-miR-15b-5p PRKACA -0.23056694141356 0.0824765001857524 0.366734298281576 0.000187937709098445 miRNATAP -0.152941432259851 2.28347891457603e-05 NA NA NA hsa-miR-374b-3p PRKACA 0.137420230218985 0.305318192448798 0.366734298281576 0.000187937709098445 mirMAP -0.12450872310223 0.000539430321626312 NA NA NA hsa-miR-744-5p PRKACA 0.37886837731794 0.00125071229180012 0.366734298281576 0.000187937709098445 miRNAWalker2_validate -0.115884324772662 0.0046979329289167 NA NA NA hsa-miR-17-5p PRKACB -0.698861147045456 2.43854106455432e-05 0.439902334736787 5.5010517587571e-05 TargetScan -0.144472658686219 5.56449338176546e-06 NA NA NA hsa-miR-193a-3p PRKACB 0.117675551589899 0.309391958208565 0.439902334736787 5.5010517587571e-05 miRanda -0.138772633279135 0.00285551569786557 NA NA NA hsa-miR-19b-3p PRKACB -0.601279551368823 0.000166850970852514 0.439902334736787 5.5010517587571e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.115986971473871 0.00048141723506022 NA NA NA hsa-miR-93-5p PRKACB -1.39518349670952 2.84167728726739e-25 0.439902334736787 5.5010517587571e-05 miRNAWalker2_validate -0.135496406586043 0.000297518311204663 NA NA NA hsa-miR-142-5p PRKCA 1.44575553250033 1.18797044680572e-13 -0.662827897377547 1.5305893364125e-08 mirMAP -0.253211662252116 4.3295868991415e-20 NA NA NA hsa-miR-146a-5p PRKCA 0.742958238440576 0.000765983177482611 -0.662827897377547 1.5305893364125e-08 mirMAP -0.137245496572864 1.03630471721186e-07 NA NA NA hsa-miR-150-5p PRKCA 1.14624309254329 1.51365525978726e-06 -0.662827897377547 1.5305893364125e-08 mirMAP -0.222341791889769 1.93250353571038e-22 NA NA NA hsa-miR-181a-5p PRKCA -0.25011343590295 0.0551933249319328 -0.662827897377547 1.5305893364125e-08 mirMAP -0.254408568412877 7.16377375327665e-09 NA NA NA hsa-miR-181b-5p PRKCA -0.488256489401109 0.00105321129419699 -0.662827897377547 1.5305893364125e-08 mirMAP -0.205095445188407 8.90870928470555e-08 NA NA NA hsa-miR-181c-5p PRKCA 0.00639394152050299 0.969127212255928 -0.662827897377547 1.5305893364125e-08 mirMAP -0.183322604105065 1.38074332954132e-07 NA NA NA hsa-miR-1976 PRKCA 0.431472440543166 0.00324575010550949 -0.662827897377547 1.5305893364125e-08 miRNATAP -0.183056349310667 3.0318716310551e-06 NA NA NA hsa-miR-218-5p PRKCA 0.500091158894852 0.0398595700240752 -0.662827897377547 1.5305893364125e-08 mirMAP -0.148170646737725 2.1349888993316e-10 NA NA NA hsa-miR-22-5p PRKCA 0.630365901263173 3.32415348030402e-05 -0.662827897377547 1.5305893364125e-08 mirMAP -0.251052842185981 1.31444858545747e-11 NA NA NA hsa-miR-2355-3p PRKCA 0.471227472721651 0.00718598113738341 -0.662827897377547 1.5305893364125e-08 mirMAP -0.157103097222143 1.75080235522893e-06 NA NA NA hsa-miR-24-2-5p PRKCA 0.570999109789416 0.000447358572601553 -0.662827897377547 1.5305893364125e-08 miRNAWalker2_validate -0.215395057998791 6.57823794606976e-10 22911661 Preferential star strand biogenesis of pre miR 24 2 targets PKC alpha and suppresses cell survival in MCF 7 breast cancer cells poor survival breast cancer hsa-miR-29b-2-5p PRKCA 0.223258653034776 0.0843061465199331 -0.662827897377547 1.5305893364125e-08 mirMAP -0.18197054047472 4.89908312952123e-05 NA NA NA hsa-miR-330-3p PRKCA 0.332364259424489 0.0316051913061457 -0.662827897377547 1.5305893364125e-08 mirMAP -0.210648698518416 2.68188227678048e-08 NA NA NA hsa-miR-381-3p PRKCA 1.11307533852141 4.70760087251719e-06 -0.662827897377547 1.5305893364125e-08 mirMAP -0.100091563011784 1.9205952275757e-05 NA NA NA hsa-miR-450b-5p PRKCA 1.34333360369432 2.6838607979045e-17 -0.662827897377547 1.5305893364125e-08 PITA;mirMAP;miRNATAP -0.224507062259025 6.89309401647265e-11 NA NA NA hsa-miR-495-3p PRKCA 0.751193061269955 0.00388779118736627 -0.662827897377547 1.5305893364125e-08 mirMAP -0.103006977344404 3.01377161842223e-06 NA NA NA hsa-miR-505-3p PRKCA 1.20027021591555 1.27927500175911e-13 -0.662827897377547 1.5305893364125e-08 miRNAWalker2_validate -0.100809044268482 0.00372474801967268 NA NA NA hsa-miR-654-3p PRKCA 1.72200544726291 6.91948971554614e-10 -0.662827897377547 1.5305893364125e-08 mirMAP -0.104555302741979 1.91014801150244e-07 NA NA NA hsa-miR-194-5p PRKCB 0.29253016099247 0.099614138487652 1.62067363753233 3.76201992658754e-13 miRNATAP -0.310861421038956 6.51903986219064e-07 NA NA NA hsa-miR-23b-3p PRKCB 0.530561587109029 5.43807206823475e-07 1.62067363753233 3.76201992658754e-13 mirMAP -0.286204121948097 0.00657996649038471 NA NA NA hsa-miR-30d-5p PRKCB -0.718283816348027 2.47422074061319e-08 1.62067363753233 3.76201992658754e-13 mirMAP -0.362125630736335 2.22146697946039e-05 NA NA NA hsa-miR-340-5p PRKCB 0.0047761453138202 0.968502722773762 1.62067363753233 3.76201992658754e-13 mirMAP -0.225497683155663 0.0158024495898231 NA NA NA hsa-miR-361-5p PRKCB -0.233202959858694 0.00961572812255393 1.62067363753233 3.76201992658754e-13 MirTarget;miRanda;miRNATAP -0.424918272347972 0.000711090604030861 NA NA NA hsa-miR-589-3p PRKCB -1.16846704028095 5.88525574424201e-11 1.62067363753233 3.76201992658754e-13 mirMAP -0.228692909978861 0.000252673885842927 NA NA NA hsa-miR-589-5p PRKCB -1.18593770505086 1.01781241960567e-22 1.62067363753233 3.76201992658754e-13 mirMAP -0.552773953594914 1.64276000301029e-10 NA NA NA hsa-miR-616-5p PRKCB -0.15056990463822 0.402836556304531 1.62067363753233 3.76201992658754e-13 mirMAP -0.245704989615516 7.89898683278172e-05 NA NA NA hsa-miR-664a-3p PRKCB -0.485807855553028 0.000732553249798648 1.62067363753233 3.76201992658754e-13 mirMAP -0.348212449855556 6.35284546408206e-06 NA NA NA hsa-miR-128-3p PRKX -0.289735108018705 0.0114419474207908 0.240211607134997 0.240371070351316 MirTarget -0.177065931374921 0.0432124195545335 NA NA NA hsa-miR-140-3p PRKX -0.546012239205325 4.84578261098881e-11 0.240211607134997 0.240371070351316 mirMAP -0.414153706871003 0.000486275257531284 NA NA NA hsa-miR-148a-3p PRKX 0.748702855597006 3.93313343865502e-07 0.240211607134997 0.240371070351316 MirTarget -0.590431480469924 2.08013051455884e-20 NA NA NA hsa-miR-16-1-3p PRKX -0.392360028038556 0.00112481918108207 0.240211607134997 0.240371070351316 MirTarget -0.244568911489674 0.00313195084634789 NA NA NA hsa-miR-23b-3p PRKX 0.530561587109029 5.43807206823475e-07 0.240211607134997 0.240371070351316 mirMAP -0.336626794798551 0.000311507204483922 NA NA NA hsa-miR-26b-3p PRKX 1.25503731613309 4.45390890119649e-27 0.240211607134997 0.240371070351316 mirMAP -0.22275165341533 0.00569151212175373 NA NA NA hsa-miR-33a-5p PRKX 0.767474460958524 1.09948756118516e-05 0.240211607134997 0.240371070351316 mirMAP -0.202109755439834 0.000339503602376678 NA NA NA hsa-miR-374a-3p PRKX 0.207171354826929 0.0623494608399903 0.240211607134997 0.240371070351316 mirMAP -0.334277813432835 0.000202864124975447 NA NA NA hsa-miR-576-5p PRKX 0.37745200828585 0.00470735657343959 0.240211607134997 0.240371070351316 mirMAP -0.216716249090268 0.00370148195253601 NA NA NA hsa-miR-101-3p RAC1 1.48176407980989 3.9895070738552e-31 -0.216579201672398 0.0029332690587434 miRNAWalker2_validate;MirTarget -0.160619583159355 2.13421294167009e-10 25202416;24649082;25057058 In previous studies the role of miRNA-101 miR-101 in tumors has been identified as a tumor suppressor and until now the role of miR-101 and Rac1 in thyroid cancer has remained undefined; Rac1 was demonstrated to be negatively regulated by miR-101 at the post-transcriptional level via a specific target site within the 3' untranslated region by dual-luciferase reporter assay; The expression of Rac1 was also observed to inversely correlate with miR-101 expression in PTC tissues; knockdown of Rac1 by shRNA inhibited thyroid cancer cell migration and invasion resembling that of miR-101 overexpression; Thus these findings suggested that miR-101 acts as a novel suppressor by targeting the Rac1 gene and inhibiting thyroid cancer cell migration and invasion;miR 101 inhibits cell proliferation by targeting Rac1 in papillary thyroid carcinoma; In the present study we investigated the role of microRNA-101 miR-101 in PTC via targeting of Ras-related C3 botulinum toxin substrate 1 Rac1; Moreover algorithm-based and experimental strategies verified Rac1 as a direct target of miR-101 in the K1 cell line; Taken together these findings suggest that miR-101 inhibited PTC growth via the downregulation of Rac1 expression providing a better understanding of miRNA-modulated signaling networks for future cancer therapeutics;Mir-101 inhibitors significantly increased the luciferase activities of RAC1 3'UTR; Overexpression of mir-101 increased the expression of RAC1 while inhibition of mir-101 suppressed RAC1 expression; mir-101 can suppress RAC1 gene expression by targeting the specific sequence of RAC1 3'UTR cell migration;; thyroid cancer;thyroid cancer;colorectal cancer hsa-miR-193b-3p RAC2 0.166697207281751 0.272022543069474 0.540909479889972 0.00736745718035633 miRNAWalker2_validate -0.246231671968469 0.000150422998204956 NA NA NA hsa-miR-125a-5p RAC3 0.912199693723822 1.38256246489542e-07 -0.670983769148772 0.00109278799508609 PITA -0.323616313906469 9.94727754352694e-09 NA NA NA hsa-miR-342-3p RAC3 0.31967731498426 0.0449813878317159 -0.670983769148772 0.00109278799508609 miRanda -0.17569839241443 0.00542104916104601 NA NA NA hsa-miR-139-5p RBX1 2.11299531796557 8.16407076414796e-28 -0.274400956900291 0.00162986680164283 miRanda -0.10537307725778 2.07264839791855e-07 NA NA NA hsa-miR-324-5p ROCK1 -0.372933276649779 0.00592280066108939 0.264366618624454 0.00575875249305318 MirTarget;PITA;miRanda -0.132464043588386 0.000113488217308036 NA NA NA hsa-miR-17-5p ROCK2 -0.698861147045456 2.43854106455432e-05 0.343723141838988 0.0978147147700797 TargetScan -0.230848684676223 0.000132737616833034 NA NA NA hsa-miR-26b-5p RUVBL1 1.10804856399745 4.14176110313907e-22 -0.570271603996128 2.73896207316383e-12 miRNAWalker2_validate -0.179459875721934 8.06930239076196e-08 NA NA NA hsa-miR-30d-5p SENP2 -0.718283816348027 2.47422074061319e-08 0.190471311633308 0.0134284544190256 miRNAWalker2_validate -0.112626849681625 8.04674267628183e-05 NA NA NA hsa-miR-98-5p SENP2 0.0487189107419477 0.715911066732523 0.190471311633308 0.0134284544190256 miRNAWalker2_validate -0.121252415185526 1.4190660620654e-05 NA NA NA hsa-miR-1301-3p SFRP1 -1.12156714169769 4.22404125385233e-10 4.14637823674297 1.04005427998815e-32 MirTarget -0.326166528078997 0.00113518434436241 NA NA NA hsa-miR-146b-5p SFRP1 -0.41971954679544 0.0457375823220201 4.14637823674297 1.04005427998815e-32 MirTarget -0.215066445935128 0.0140810441727555 NA NA NA hsa-miR-16-1-3p SFRP1 -0.392360028038556 0.00112481918108207 4.14637823674297 1.04005427998815e-32 MirTarget -0.71551742776429 2.38771391079108e-06 NA NA NA hsa-miR-182-5p SFRP1 -1.96601340710222 4.39326175603683e-09 4.14637823674297 1.04005427998815e-32 mirMAP -0.129762765663797 0.015988108793524 NA NA NA hsa-miR-192-3p SFRP1 0.640116511400704 0.000266272092403793 4.14637823674297 1.04005427998815e-32 MirTarget -0.424962367232444 4.17845072192868e-05 NA NA NA hsa-miR-501-5p SFRP1 -1.15231083477882 2.98906150004095e-10 4.14637823674297 1.04005427998815e-32 mirMAP -0.477662273757518 1.00728429943687e-06 NA NA NA hsa-miR-548b-3p SFRP1 0.0203576084717128 0.930819503166958 4.14637823674297 1.04005427998815e-32 mirMAP -0.432545827935783 3.67109378834241e-08 NA NA NA hsa-miR-548j-5p SFRP1 -0.251239647701947 0.171361975450223 4.14637823674297 1.04005427998815e-32 MirTarget -0.453370953209203 1.05214745425183e-05 NA NA NA hsa-miR-940 SFRP1 -0.453020092551483 0.0177054921651998 4.14637823674297 1.04005427998815e-32 MirTarget -0.248779732986302 0.0121273033245209 NA NA NA hsa-miR-33a-3p SFRP2 0.683025859637737 1.01106097756419e-05 -0.468120194073393 0.289027671938252 miRNATAP -0.315562038049221 0.0225849071322924 NA NA NA hsa-miR-455-5p SFRP2 0.270546034117159 0.0581320703577714 -0.468120194073393 0.289027671938252 miRanda -0.795717260851726 9.71330692924213e-08 NA NA NA hsa-miR-144-5p SFRP4 1.54604938792018 1.06886492586605e-10 -2.13318024807939 8.83329524470029e-10 MirTarget -0.351626376323752 4.90563413861651e-07 NA NA NA hsa-miR-26b-5p SFRP4 1.10804856399745 4.14176110313907e-22 -2.13318024807939 8.83329524470029e-10 miRNAWalker2_validate -0.774813965686543 5.2927899458002e-08 NA NA NA hsa-miR-3607-3p SFRP4 2.15518588554494 1.03390728226714e-23 -2.13318024807939 8.83329524470029e-10 MirTarget -0.343276705360189 5.59321744727563e-06 NA NA NA hsa-miR-532-5p SFRP4 -1.027295465106 9.93318913967036e-16 -2.13318024807939 8.83329524470029e-10 MirTarget -0.271814490134315 0.0386462407402257 NA NA NA hsa-miR-146b-5p SFRP5 -0.41971954679544 0.0457375823220201 6.77024588580237 2.4183901828315e-29 miRanda -0.322537811676363 0.0319024958905886 NA NA NA hsa-miR-532-5p SIAH1 -1.027295465106 9.93318913967036e-16 0.248598766920749 0.000491682203063587 PITA;miRNATAP -0.102457696857658 9.08176167400043e-05 NA NA NA hsa-miR-450b-5p SKP1 1.34333360369432 2.6838607979045e-17 -0.220350434523826 0.00211239594525251 miRNATAP -0.104764813664882 5.36557139667176e-07 NA NA NA hsa-miR-7-1-3p SKP1 0.569105143287802 1.85297665041411e-05 -0.220350434523826 0.00211239594525251 MirTarget;mirMAP -0.109724018574561 2.33101260912259e-05 NA NA NA hsa-miR-455-5p SMAD2 0.270546034117159 0.0581320703577714 -0.315604980822303 9.76507196938079e-07 miRanda -0.126014730396316 7.82261975485323e-09 NA NA NA hsa-let-7g-3p SMAD3 1.14091000722297 8.3273601818868e-19 -0.313849246286879 0.00280528337161092 mirMAP -0.100129949934208 0.00883180340844614 NA NA NA hsa-miR-142-5p SMAD3 1.44575553250033 1.18797044680572e-13 -0.313849246286879 0.00280528337161092 PITA -0.125868007472141 6.14850270977044e-07 NA NA NA hsa-miR-155-5p SMAD3 -0.0108524225071811 0.956513310335039 -0.313849246286879 0.00280528337161092 miRNAWalker2_validate -0.143616291871971 1.61818308217997e-08 27626488 Here we demonstrated that TGF-β1 elevated the expression of miR-155 in colorectal cancer cells through SMAD3 and SMAD4 colorectal cancer hsa-miR-1976 SMAD3 0.431472440543166 0.00324575010550949 -0.313849246286879 0.00280528337161092 MirTarget -0.177460759581402 2.8140086065009e-07 NA NA NA hsa-miR-29b-2-5p SMAD3 0.223258653034776 0.0843061465199331 -0.313849246286879 0.00280528337161092 mirMAP -0.124265788567886 0.00177731205069881 NA NA NA hsa-miR-30e-3p SMAD3 1.20845647373031 3.10263633528088e-25 -0.313849246286879 0.00280528337161092 mirMAP -0.103475289171098 0.0130534195616259 NA NA NA hsa-miR-326 SMAD3 1.881935132554 1.68087316863775e-21 -0.313849246286879 0.00280528337161092 miRanda -0.121886887629074 7.48502793476032e-07 NA NA NA hsa-miR-424-5p SMAD3 2.62653257498508 2.38997974737922e-50 -0.313849246286879 0.00280528337161092 MirTarget -0.105846554796035 3.45471115916176e-05 27655675 miR 424 5p promotes proliferation of gastric cancer by targeting Smad3 through TGF β signaling pathway; QRT-PCR was used to determine the expression levels of miR-424-5p and Smad3; Luciferase reporter assay and western blotting were used to prove that Smad3 was one of the direct targets of miR-424-5p; In addition luciferase reporter assay and western blotting assay revealed that Smad3 was a direct target of miR-424-5p; Over-expression of Smad3 could partially reverse the effects of miR-424-5p on GC cell proliferation; Our study further revealed that miR-424-5p could inhibit TGF-β signaling pathway by Smad3 gastric cancer hsa-miR-29b-2-5p SMAD4 0.223258653034776 0.0843061465199331 0.309760546301811 7.55983294716972e-05 MirTarget -0.1066651080199 0.000315915680961711 NA NA NA hsa-miR-34a-5p SMAD4 -1.03694231790864 5.7486401954075e-14 0.309760546301811 7.55983294716972e-05 miRNATAP -0.106481148933391 7.14459232465546e-05 22750848 Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network; Specifically in glioblastoma within the context of the global network promoter enrichment analysis of network edges uncovered a novel regulation of TGF-β signaling via a Smad4 transcriptomic network by miR-34a glioblastoma hsa-miR-500a-5p SMAD4 -0.797906382969155 9.1595817108425e-08 0.309760546301811 7.55983294716972e-05 mirMAP -0.104579732494838 3.18281872137464e-05 NA NA NA hsa-miR-421 SOX17 -0.94185633469408 6.12167297054091e-08 -0.0768945916400992 0.622559659278873 miRanda -0.206772288415577 1.37004602672215e-06 NA NA NA hsa-miR-590-3p SOX17 0.47316749804781 1.76652934637215e-05 -0.0768945916400992 0.622559659278873 miRanda;miRNATAP -0.309598201550693 5.80979934015017e-06 NA NA NA hsa-miR-590-5p SOX17 0.103355559980407 0.310027295317082 -0.0768945916400992 0.622559659278873 miRanda -0.398203292429146 9.1083599709098e-08 NA NA NA hsa-miR-142-3p TBL1X 1.4243101967815 1.92609481097759e-14 0.210527078758217 0.0538137802227029 MirTarget;PITA;miRanda;miRNATAP -0.102243557257819 0.000205263330309458 NA NA NA hsa-miR-181a-5p TBL1X -0.25011343590295 0.0551933249319328 0.210527078758217 0.0538137802227029 MirTarget;miRNATAP -0.195981076452364 1.31283993255368e-06 NA NA NA hsa-miR-181b-5p TBL1X -0.488256489401109 0.00105321129419699 0.210527078758217 0.0538137802227029 MirTarget;miRNATAP -0.174048839194183 7.72788457911812e-07 NA NA NA hsa-miR-181c-5p TBL1X 0.00639394152050299 0.969127212255928 0.210527078758217 0.0538137802227029 MirTarget;miRNATAP -0.176940535352193 2.67948938267401e-08 NA NA NA hsa-miR-181d-5p TBL1X -0.161600964883515 0.363806828763005 0.210527078758217 0.0538137802227029 MirTarget -0.150698378969438 3.52959108534418e-07 NA NA NA hsa-miR-22-5p TBL1X 0.630365901263173 3.32415348030402e-05 0.210527078758217 0.0538137802227029 mirMAP -0.164677596181407 1.74814844588779e-06 NA NA NA hsa-miR-23a-3p TBL1X 0.178875974460576 0.1359782735406 0.210527078758217 0.0538137802227029 mirMAP -0.228894929085056 2.04204585882439e-07 NA NA NA hsa-miR-330-3p TBL1X 0.332364259424489 0.0316051913061457 0.210527078758217 0.0538137802227029 PITA;miRNATAP -0.134992238830743 0.000116417327767035 NA NA NA hsa-miR-484 TBL1X -0.0857240033709612 0.453982056282252 0.210527078758217 0.0538137802227029 PITA -0.189487582371112 4.68676536635706e-05 NA NA NA hsa-miR-769-5p TBL1X -0.219661452072769 0.0333425465750595 0.210527078758217 0.0538137802227029 PITA -0.150345581661419 0.00375599630962997 NA NA NA hsa-miR-92b-3p TBL1X -0.220374930803972 0.296187538889097 0.210527078758217 0.0538137802227029 mirMAP -0.133801284507777 7.54893093059948e-08 NA NA NA hsa-miR-125a-5p TCF7 0.912199693723822 1.38256246489542e-07 -0.316885181039241 0.149291794426299 miRanda -0.219010892235073 0.000315267733055781 NA NA NA hsa-miR-133a-3p TCF7 0.628141411173507 0.0119847391134835 -0.316885181039241 0.149291794426299 MirTarget -0.211821210882707 7.11167273763377e-07 NA NA NA hsa-miR-214-5p TCF7 1.91497809567701 3.92955595018154e-12 -0.316885181039241 0.149291794426299 mirMAP -0.191495267228143 4.22277775127685e-07 NA NA NA hsa-miR-215-5p TCF7 0.981544773246516 3.14452272477116e-05 -0.316885181039241 0.149291794426299 miRNAWalker2_validate;MirTarget -0.173472143860975 0.000107082025354146 NA NA NA hsa-miR-217 TCF7 -1.0579729754038 0.0401026692682437 -0.316885181039241 0.149291794426299 miRanda -0.130094871894507 1.43494780327072e-10 NA NA NA hsa-miR-24-3p TCF7 0.257825594021959 0.00689742600215214 -0.316885181039241 0.149291794426299 miRNATAP -0.557846852041242 6.44555716594922e-07 NA NA NA hsa-miR-30a-3p TCF7 1.52720594401486 1.38300660757065e-17 -0.316885181039241 0.149291794426299 mirMAP -0.188251012405998 0.00103354405224303 NA NA NA hsa-miR-30c-2-3p TCF7 1.39811819128588 3.66376924527554e-15 -0.316885181039241 0.149291794426299 mirMAP -0.120581004200486 0.0387679931918317 NA NA NA hsa-miR-30e-3p TCF7 1.20845647373031 3.10263633528088e-25 -0.316885181039241 0.149291794426299 mirMAP -0.346228359167188 6.3617494517767e-05 NA NA NA hsa-miR-331-3p TCF7 0.283974346994632 0.037378541105322 -0.316885181039241 0.149291794426299 MirTarget;miRNATAP -0.479855997763643 5.36153680989195e-10 NA NA NA hsa-miR-3913-5p TCF7 -0.247553671224336 0.0627950110811883 -0.316885181039241 0.149291794426299 mirMAP -0.187857504595077 0.0205845576941435 NA NA NA hsa-miR-491-5p TCF7 0.369122930844418 0.0154047757048929 -0.316885181039241 0.149291794426299 MirTarget;PITA;miRanda;miRNATAP -0.176537669938362 0.012983394482481 NA NA NA hsa-miR-628-3p TCF7 0.958478775877672 6.18965095549217e-08 -0.316885181039241 0.149291794426299 PITA -0.225172851464629 0.000189335912104454 NA NA NA hsa-miR-204-5p TCF7L1 0.537962150012098 0.0330895493358864 0.133055904354748 0.400767225696704 MirTarget;miRNATAP -0.160817949371994 9.24763373186673e-08 NA NA NA hsa-miR-30b-3p TCF7L1 0.439724365151374 0.000947180503583578 0.133055904354748 0.400767225696704 MirTarget -0.128187741203912 0.027049850040723 NA NA NA hsa-miR-132-3p TCF7L2 -0.32379623969599 0.00272093067935146 0.337137194899191 7.09586898305261e-05 miRNATAP -0.163055557451342 2.13639390460484e-05 NA NA NA hsa-miR-942-5p TCF7L2 -0.346451845105261 0.0283255399972349 0.337137194899191 7.09586898305261e-05 MirTarget -0.102128789748066 9.53611863162584e-05 NA NA NA hsa-miR-122-5p TP53 1.23907441373957 4.42181244888522e-06 0.163823087975334 0.268013799235927 miRNATAP -0.104401376732605 6.76735273123785e-05 23221562;22235305 Loss of miR-122 expression in patients with hepatitis B enhances hepatitis B virus replication through cyclin G1-modulated P53 activity.;Surprisingly miR-122 overexpression decreased the sensitivity to the chemotherapy-induced apoptosis via a signaling circuit involving the activation of Akt and inhibition of p53 ; liver cancer;lymphoma hsa-miR-25-3p TP53 -0.63306256355637 3.68686354834514e-10 0.163823087975334 0.268013799235927 miRNAWalker2_validate -0.198477612132015 0.00480268903724675 22431589 The results define miR-25 and -32 as positive regulators of p53 underscoring their role in tumorigenesis in glioblastoma tumorigenesis glioblastoma hsa-miR-126-5p VANGL1 0.428561469405592 6.60355858442263e-05 -0.205997711038245 0.0305684838095015 mirMAP -0.110689665781076 0.0103821317781044 NA NA NA hsa-miR-148a-3p VANGL1 0.748702855597006 3.93313343865502e-07 -0.205997711038245 0.0305684838095015 mirMAP -0.147424701729889 1.65338009649548e-06 NA NA NA hsa-miR-192-3p VANGL1 0.640116511400704 0.000266272092403793 -0.205997711038245 0.0305684838095015 mirMAP -0.219767721572736 2.87368717362652e-18 NA NA NA hsa-miR-192-5p VANGL1 0.50188499512787 0.00344713341196035 -0.205997711038245 0.0305684838095015 miRNAWalker2_validate -0.228603360029257 8.99222292327043e-19 NA NA NA hsa-miR-22-3p VANGL1 0.628561621952411 1.33755558015497e-09 -0.205997711038245 0.0305684838095015 mirMAP -0.201656582804415 4.23251723606763e-06 NA NA NA hsa-miR-365a-3p VANGL1 -0.164591326307709 0.153250849632141 -0.205997711038245 0.0305684838095015 miRNAWalker2_validate -0.111778265796733 0.00578137301221365 NA NA NA hsa-miR-107 VANGL2 -0.241662461253454 0.0170788899505421 0.695002958600545 0.0292238308957977 miRanda -0.708132234132303 4.03206007205814e-06 NA NA NA hsa-miR-140-3p VANGL2 -0.546012239205325 4.84578261098881e-11 0.695002958600545 0.0292238308957977 PITA;miRNATAP -0.749116548016374 5.12318056320725e-05 NA NA NA hsa-miR-33a-3p VANGL2 0.683025859637737 1.01106097756419e-05 0.695002958600545 0.0292238308957977 miRNATAP -0.199082031473265 0.0468848537135867 NA NA NA hsa-miR-362-3p VANGL2 -0.814007335895912 2.00108618836575e-09 0.695002958600545 0.0292238308957977 PITA;miRanda;miRNATAP -0.330222176686103 0.00341929011907735 NA NA NA hsa-miR-362-5p VANGL2 -0.717921690799307 1.68392734504546e-05 0.695002958600545 0.0292238308957977 mirMAP -0.275715941169569 0.00286899532483676 NA NA NA hsa-miR-378a-5p VANGL2 1.58667444700188 3.19640857320476e-17 0.695002958600545 0.0292238308957977 MirTarget -0.376638409057428 1.76672899983547e-06 NA NA NA hsa-miR-589-5p VANGL2 -1.18593770505086 1.01781241960567e-22 0.695002958600545 0.0292238308957977 mirMAP -0.401995112344914 0.001013418640154 NA NA NA hsa-miR-139-5p WIF1 2.11299531796557 8.16407076414796e-28 -0.556794941584029 0.112853637115858 miRanda -0.173226865020953 0.0367605397245844 NA NA NA hsa-miR-28-5p WIF1 0.43096483059997 2.67367257252851e-06 -0.556794941584029 0.112853637115858 miRanda -0.495201246744867 0.00804338317259052 NA NA NA hsa-miR-326 WIF1 1.881935132554 1.68087316863775e-21 -0.556794941584029 0.112853637115858 miRanda -0.188891330636829 0.0232807883162792 NA NA NA hsa-miR-378a-3p WNT10A 1.1920055906972 3.23538871733595e-10 0.699775326592299 0.0148377695277892 MirTarget;miRNATAP -0.311876203963016 1.46588032688135e-05 NA NA NA hsa-miR-378c WNT10A 1.54028191929039 2.70131554214845e-15 0.699775326592299 0.0148377695277892 MirTarget;miRNATAP -0.223225797245087 0.00130113406406967 NA NA NA hsa-miR-664a-3p WNT10A -0.485807855553028 0.000732553249798648 0.699775326592299 0.0148377695277892 mirMAP -0.334039889137342 0.000582315884836279 NA NA NA hsa-miR-362-3p WNT2 -0.814007335895912 2.00108618836575e-09 3.91913726472358 3.44531322240169e-22 miRanda -0.596906309855373 7.09333385741009e-05 NA NA NA hsa-miR-532-5p WNT2 -1.027295465106 9.93318913967036e-16 3.91913726472358 3.44531322240169e-22 miRNATAP -1.17021689287712 1.95625819314329e-14 NA NA NA hsa-miR-548b-3p WNT2 0.0203576084717128 0.930819503166958 3.91913726472358 3.44531322240169e-22 MirTarget -0.502061495825289 1.54565101391317e-08 NA NA NA hsa-miR-186-5p WNT2B 0.0601033913736888 0.535288717081192 -0.91979738873125 8.8418432189491e-05 mirMAP -0.262005001733846 0.0298365448191553 NA NA NA hsa-miR-32-3p WNT2B -0.219109440121582 0.207217051619542 -0.91979738873125 8.8418432189491e-05 mirMAP -0.226091442559667 0.000967084434027044 NA NA NA hsa-miR-576-5p WNT2B 0.37745200828585 0.00470735657343959 -0.91979738873125 8.8418432189491e-05 mirMAP -0.212062198715795 0.0142007408890705 NA NA NA hsa-miR-616-5p WNT2B -0.15056990463822 0.402836556304531 -0.91979738873125 8.8418432189491e-05 mirMAP -0.357146678596839 1.78631568677685e-08 NA NA NA hsa-miR-1301-3p WNT3 -1.12156714169769 4.22404125385233e-10 0.0427691985857289 0.782956133291659 miRNAWalker2_validate -0.111768467724203 0.00665968425980419 NA NA NA hsa-miR-146a-5p WNT3 0.742958238440576 0.000765983177482611 0.0427691985857289 0.782956133291659 MirTarget -0.113145320629351 0.000853907137316349 NA NA NA hsa-miR-324-3p WNT3 -0.260348469146492 0.0506141704203561 0.0427691985857289 0.782956133291659 MirTarget -0.152449309964257 0.0073953316853805 NA NA NA hsa-miR-671-5p WNT3 -0.843645373345786 3.92794196273325e-08 0.0427691985857289 0.782956133291659 MirTarget -0.122495664510585 0.0117037669843825 NA NA NA hsa-miR-195-5p WNT3A 1.85907534356434 1.47434041676385e-22 -1.987086168701 1.63071643507262e-06 MirTarget;miRNATAP -0.344445023915739 0.000703711150128669 25174704;26573286 MicroRNA 195 acts as a tumor suppressor by directly targeting Wnt3a in HepG2 hepatocellular carcinoma cells; Luciferase reporter assay was used to determine whether Wnt3a was a target of miR-195; Furthermore Wnt3a was demonstrated to be directly targeted by miR-195; These findings suggest that miR-195 is key in regulating cell proliferation cell cycle and apoptosis through targeting Wnt3a;Eribulin upregulates miR 195 expression and downregulates Wnt3a expression in non basal like type of triple negative breast cancer cell MDA MB 231; The expression level of miR-195 targeting Wnt3a significantly decreased compared to the control in MDA-MB-231 whereas it significantly increased in HCC1143; These results showed that exposure to eribulin highly increased the expression of miR-195 while it decreased the expression of Wnt3a in non-basal-like type of TNBC ; liver cancer;breast cancer hsa-miR-27b-3p WNT3A 0.823491817819763 9.20935302746338e-14 -1.987086168701 1.63071643507262e-06 miRNATAP -0.548421477531898 0.00239496180403094 NA NA NA hsa-miR-335-5p WNT3A 1.61347836513558 1.62757083289686e-19 -1.987086168701 1.63071643507262e-06 mirMAP -0.466783584252119 1.77594430006242e-05 NA NA NA hsa-miR-424-5p WNT3A 2.62653257498508 2.38997974737922e-50 -1.987086168701 1.63071643507262e-06 MirTarget;miRNATAP -0.276402093402075 0.00707893809064417 NA NA NA hsa-miR-107 WNT4 -0.241662461253454 0.0170788899505421 0.395843982979098 0.363792495355893 PITA;miRNATAP -1.20015521254906 8.09058681955679e-09 NA NA NA hsa-miR-375 WNT5A 1.93190458972329 4.28108492521988e-06 0.379867591757489 0.265970692489083 miRNATAP -0.114882013104506 0.00325292733019044 NA NA NA hsa-miR-885-5p WNT5A 0.940994379567568 0.00118729865914982 0.379867591757489 0.265970692489083 MirTarget;PITA -0.12433712248163 0.0293178719088217 NA NA NA hsa-miR-92a-3p WNT5A -0.212391012518189 0.134292268090006 0.379867591757489 0.265970692489083 miRNAWalker2_validate -0.276916724545173 0.0188316136630208 NA NA NA hsa-miR-185-5p WNT5B -0.480006257154714 6.35758891340259e-07 1.13697207573161 0.000217274755514594 miRNAWalker2_validate -0.637058578135861 4.15131637965874e-05 NA NA NA hsa-miR-10b-5p WNT7B -2.86931593037303 6.97409423207806e-23 2.49986156980565 3.55477150766277e-09 mirMAP -0.274981207829556 5.13137898629338e-05 NA NA NA hsa-miR-34a-5p WNT7B -1.03694231790864 5.7486401954075e-14 2.49986156980565 3.55477150766277e-09 mirMAP -0.871435014929295 2.29802092991709e-09 NA NA NA hsa-miR-505-3p WNT7B 1.20027021591555 1.27927500175911e-13 2.49986156980565 3.55477150766277e-09 miRNATAP -0.343304152336908 0.00653008300029439 NA NA NA hsa-miR-664a-5p WNT7B 0.0738022124558593 0.597681758599428 2.49986156980565 3.55477150766277e-09 MirTarget -0.350084715832488 0.0208450119464205 NA NA NA