miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-16-5p ALDH18A1 -0.398577235179603 0.000101598495180191 0.350223715973654 0.00111390364387578 miRNAWalker2_validate -0.126144056733405 0.0140228788394129 NA NA NA hsa-miR-30d-3p ATM -0.120562286038759 0.329549534782125 -0.236058797850924 0.0173776926910908 mirMAP -0.138156674894502 0.00042794166032829 24345332 miR-30d has been observed to be significantly down-regulated in human anaplastic thyroid carcinoma ATC and is believed to be an important event in thyroid cell transformation; In this study we found that miR-30d has a critical role in modulating sensitivity of ATC cells to cisplatin a commonly used chemotherapeutic drug for treatment of this neoplasm; Using a mimic of miR-30d we demonstrated that miR-30d could negatively regulate the expression of beclin 1 a key autophagy gene leading to suppression of the cisplatin-activated autophagic response that protects ATC cells from apoptosis; We further showed that inhibition of the beclin 1-mediated autophagy by the miR-30d mimic sensitized ATC cells to cisplatin both in vitro cell culture and in vivo animal xenograft model; These results suggest that dysregulation of miR-30d in ATC cells is responsible for the insensitivity to cisplatin by promoting autophagic survival; Thus miR-30d may be exploited as a potential target for therapeutic intervention in the treatment of ATC drug resistance;poor survival thyroid cancer hsa-miR-339-5p ATM 0.280589919878422 0.0355660282647215 -0.236058797850924 0.0173776926910908 miRanda -0.1044932927788 0.00399236512159519 NA NA NA hsa-miR-455-5p ATM -0.270546034117157 0.0581320703577731 -0.236058797850924 0.0173776926910908 miRanda -0.118715671502599 0.000450782297458542 NA NA NA hsa-miR-140-5p BID -0.220106443070144 0.0140713197101242 0.212028711841568 0.0751625972679542 miRanda -0.214836635124566 0.00100941241708294 NA NA NA hsa-miR-140-3p ITGB1 0.546012239205329 4.84578261098777e-11 0.150635638369529 0.0875061080940868 PITA -0.175902840174304 0.000564338708599815 NA NA NA hsa-miR-192-5p ITGB1 -0.50188499512787 0.00344713341196035 0.150635638369529 0.0875061080940868 miRNAWalker2_validate -0.159167916481672 6.60024481999039e-11 NA NA NA hsa-miR-590-5p ITGB1 -0.103355559980404 0.310027295317092 0.150635638369529 0.0875061080940868 miRanda -0.136906492054453 0.00125518477546468 NA NA NA hsa-miR-125a-3p ITPR2 -0.841683158494395 3.51202687176603e-05 -0.68468127740298 4.90072911451155e-05 miRanda -0.268421663487645 3.14883936662354e-11 NA NA NA hsa-miR-1271-5p ITPR2 -1.00001044718608 1.30308965099272e-09 -0.68468127740298 4.90072911451155e-05 MirTarget -0.109515751459942 0.0278785884461931 NA NA NA hsa-miR-148b-5p ITPR2 0.295777213389605 0.0255749859535438 -0.68468127740298 4.90072911451155e-05 MirTarget -0.23873717102877 0.000134994087948132 NA NA NA hsa-miR-193a-3p ITPR2 -0.117675551589896 0.309391958208578 -0.68468127740298 4.90072911451155e-05 miRanda -0.253402575003257 0.00042571076707815 NA NA NA hsa-miR-200b-3p ITPR2 -1.29335788099229 0.000268623234305059 -0.68468127740298 4.90072911451155e-05 MirTarget -0.131779911059464 7.30054033937174e-09 NA NA NA hsa-miR-200c-3p ITPR2 -0.104675615392797 0.716957669484981 -0.68468127740298 4.90072911451155e-05 MirTarget -0.200197308843578 7.87036360713507e-13 NA NA NA hsa-miR-203a-3p ITPR2 -1.34362479226226 8.69374456831293e-05 -0.68468127740298 4.90072911451155e-05 MirTarget -0.124750497399584 1.36537276819877e-07 NA NA NA hsa-miR-218-5p ITPR2 -0.500091158894849 0.0398595700240766 -0.68468127740298 4.90072911451155e-05 MirTarget -0.216727233200427 7.38744923827437e-11 NA NA NA hsa-miR-324-5p ITPR2 0.372933276649782 0.00592280066108904 -0.68468127740298 4.90072911451155e-05 miRNAWalker2_validate -0.235461906668097 0.000111365747465846 NA NA NA hsa-miR-330-5p ITPR2 0.442231058604099 0.0053308560843808 -0.68468127740298 4.90072911451155e-05 miRanda -0.436673409886046 2.77411563804969e-18 NA NA NA hsa-miR-335-3p ITPR2 -0.275199247483111 0.106629165248783 -0.68468127740298 4.90072911451155e-05 mirMAP -0.235545258764321 1.00523500441226e-06 NA NA NA hsa-miR-339-5p ITPR2 0.280589919878422 0.0355660282647215 -0.68468127740298 4.90072911451155e-05 miRanda -0.375040237762935 8.63645483694688e-10 NA NA NA hsa-miR-362-3p ITPR2 0.814007335895913 2.00108618836568e-09 -0.68468127740298 4.90072911451155e-05 MirTarget -0.134454933644537 0.025446871917154 NA NA NA hsa-miR-429 ITPR2 -1.40262535827285 6.93982219171912e-05 -0.68468127740298 4.90072911451155e-05 MirTarget;miRanda -0.123471684272904 1.14558171347511e-07 NA NA NA hsa-miR-590-5p ITPR2 -0.103355559980404 0.310027295317092 -0.68468127740298 4.90072911451155e-05 miRanda -0.251179551167985 0.00223824337105465 NA NA NA hsa-miR-766-3p ITPR2 0.199979324759329 0.257230732626744 -0.68468127740298 4.90072911451155e-05 MirTarget -0.264026069998675 1.20144568043784e-08 NA NA NA hsa-miR-940 ITPR2 0.453020092551484 0.0177054921651997 -0.68468127740298 4.90072911451155e-05 MirTarget;PITA -0.243923910210289 2.93849743751152e-08 NA NA NA hsa-miR-103a-3p PIK3R1 0.765568928457606 3.05497476509383e-12 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.187692597616198 0.00702590214654354 NA NA NA hsa-miR-106b-5p PIK3R1 0.648901865047099 8.24870862047885e-09 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.369244291882445 4.59379549667075e-08 NA NA NA hsa-miR-1301-3p PIK3R1 1.12156714169769 4.22404125385203e-10 -0.891953424131491 1.38465728969785e-08 MirTarget -0.26088137729301 3.97606431390706e-10 NA NA NA hsa-miR-132-3p PIK3R1 0.323796239695997 0.00272093067935091 -0.891953424131491 1.38465728969785e-08 MirTarget -0.517351445825174 2.17222827385203e-13 NA NA NA hsa-miR-15b-5p PIK3R1 0.230566941413564 0.0824765001857479 -0.891953424131491 1.38465728969785e-08 MirTarget -0.132325827339178 0.0249531550846148 NA NA NA hsa-miR-17-5p PIK3R1 0.698861147045461 2.43854106455398e-05 -0.891953424131491 1.38465728969785e-08 MirTarget;TargetScan;miRNATAP -0.213954808771155 3.8587060059728e-06 NA NA NA hsa-miR-185-5p PIK3R1 0.480006257154717 6.35758891340152e-07 -0.891953424131491 1.38465728969785e-08 miRNATAP -0.255181123475439 0.00153792085091181 NA NA NA hsa-miR-188-5p PIK3R1 1.11646899351496 9.56686958408598e-11 -0.891953424131491 1.38465728969785e-08 MirTarget -0.178093775716465 5.33015486626271e-05 NA NA NA hsa-miR-200c-3p PIK3R1 -0.104675615392797 0.716957669484981 -0.891953424131491 1.38465728969785e-08 mirMAP -0.105107802462856 9.06963579759966e-05 NA NA NA hsa-miR-20a-5p PIK3R1 0.854326758727003 5.04256669663285e-07 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.137431012149634 0.00237710222818209 NA NA NA hsa-miR-21-5p PIK3R1 1.51084295924322 1.54551622173259e-34 -0.891953424131491 1.38465728969785e-08 miRNAWalker2_validate;MirTarget;miRNATAP -0.626634426633867 6.01244523464713e-31 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-212-3p PIK3R1 -0.288359631986802 0.100392159518997 -0.891953424131491 1.38465728969785e-08 MirTarget -0.258090192317157 3.95293509038579e-09 NA NA NA hsa-miR-221-3p PIK3R1 1.12244756358612 3.48370308238012e-13 -0.891953424131491 1.38465728969785e-08 MirTarget -0.217914846238424 7.87055620620445e-06 NA NA NA hsa-miR-222-3p PIK3R1 1.08574156066353 1.76407192348131e-11 -0.891953424131491 1.38465728969785e-08 MirTarget -0.256619417997498 3.41697791848384e-08 NA NA NA hsa-miR-324-3p PIK3R1 0.260348469146494 0.0506141704203545 -0.891953424131491 1.38465728969785e-08 MirTarget;PITA;miRNATAP -0.281792149179102 1.26555231509763e-06 NA NA NA hsa-miR-330-3p PIK3R1 -0.332364259424489 0.0316051913061459 -0.891953424131491 1.38465728969785e-08 MirTarget;PITA;miRNATAP -0.212492102885122 3.44445995574159e-05 NA NA NA hsa-miR-338-5p PIK3R1 -0.221898432884726 0.252390988727086 -0.891953424131491 1.38465728969785e-08 PITA -0.143685656767977 0.000366657184559181 NA NA NA hsa-miR-409-3p PIK3R1 -0.499649792570937 0.0526751181520117 -0.891953424131491 1.38465728969785e-08 mirMAP -0.110448878014769 0.000237041711390918 NA NA NA hsa-miR-493-5p PIK3R1 -0.198321662045422 0.502870277689198 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.103739426368655 7.76271840065789e-05 NA NA NA hsa-miR-582-5p PIK3R1 -0.680189083316822 0.00103755166534107 -0.891953424131491 1.38465728969785e-08 mirMAP -0.138461163257927 0.00021364752999012 NA NA NA hsa-miR-589-3p PIK3R1 1.16846704028095 5.88525574424201e-11 -0.891953424131491 1.38465728969785e-08 mirMAP -0.21021578613876 1.13421126603334e-06 NA NA NA hsa-miR-590-5p PIK3R1 -0.103355559980404 0.310027295317092 -0.891953424131491 1.38465728969785e-08 MirTarget;PITA;miRanda;miRNATAP -0.299776876388425 9.9413226282672e-05 NA NA NA hsa-miR-629-3p PIK3R1 -0.315338123880353 0.119091248294946 -0.891953424131491 1.38465728969785e-08 MirTarget -0.182940394280375 3.19896248240917e-06 NA NA NA hsa-miR-93-5p PIK3R1 1.39518349670953 2.84167728726712e-25 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.319783065556515 2.89613370212511e-09 NA NA NA hsa-miR-106b-5p PLA2G12A 0.648901865047099 8.24870862047885e-09 -0.791023748042462 1.18231931629012e-15 mirMAP -0.266014267647959 5.9212435860407e-10 NA NA NA hsa-miR-140-5p PLA2G12A -0.220106443070144 0.0140713197101242 -0.791023748042462 1.18231931629012e-15 miRanda -0.148237117501735 0.00839228705095135 NA NA NA hsa-miR-17-5p PLA2G12A 0.698861147045461 2.43854106455398e-05 -0.791023748042462 1.18231931629012e-15 mirMAP -0.156166087311117 1.18493997052615e-07 NA NA NA hsa-miR-181a-5p PLA2G12A 0.250113435902954 0.0551933249319293 -0.791023748042462 1.18231931629012e-15 mirMAP -0.193778811048191 3.19565578842397e-07 NA NA NA hsa-miR-181b-5p PLA2G12A 0.488256489401108 0.00105321129419701 -0.791023748042462 1.18231931629012e-15 mirMAP -0.187398478397273 1.16778168992629e-08 NA NA NA hsa-miR-20a-5p PLA2G12A 0.854326758727003 5.04256669663285e-07 -0.791023748042462 1.18231931629012e-15 mirMAP -0.130236012494097 5.73845333718432e-06 NA NA NA hsa-miR-32-3p PLA2G12A 0.219109440121582 0.207217051619543 -0.791023748042462 1.18231931629012e-15 mirMAP -0.100135809509177 0.000715271422667235 NA NA NA hsa-miR-362-3p PLA2G12A 0.814007335895913 2.00108618836568e-09 -0.791023748042462 1.18231931629012e-15 miRanda -0.13534064202416 0.000168490865417192 NA NA NA hsa-miR-501-5p PLA2G12A 1.15231083477882 2.98906150004088e-10 -0.791023748042462 1.18231931629012e-15 miRNATAP -0.159698924847702 1.1258030900796e-09 NA NA NA hsa-miR-589-3p PLA2G12A 1.16846704028095 5.88525574424201e-11 -0.791023748042462 1.18231931629012e-15 mirMAP -0.18597386225482 8.57790590041378e-12 NA NA NA hsa-miR-625-3p PLA2G12A 0.242249841316603 0.181227779755078 -0.791023748042462 1.18231931629012e-15 mirMAP -0.135161844446821 6.99056150075446e-07 NA NA NA hsa-miR-92b-3p PLA2G12A 0.220374930803974 0.296187538889092 -0.791023748042462 1.18231931629012e-15 miRNAWalker2_validate -0.10091652542866 1.70520826049974e-05 NA NA NA hsa-miR-93-5p PLA2G12A 1.39518349670953 2.84167728726712e-25 -0.791023748042462 1.18231931629012e-15 mirMAP -0.31642455552352 2.26982563682874e-21 NA NA NA hsa-miR-103a-2-5p PLD1 1.17085533927423 5.31418969120877e-09 -1.16313063789315 9.80903873525724e-10 MirTarget -0.101670614635446 0.037376633800889 NA NA NA hsa-miR-103a-3p PLD1 0.765568928457606 3.05497476509383e-12 -1.16313063789315 9.80903873525724e-10 MirTarget -0.26368174662399 0.00179962941800181 NA NA NA hsa-miR-107 PLD1 0.241662461253461 0.0170788899505389 -1.16313063789315 9.80903873525724e-10 MirTarget;miRanda -0.531659225145908 1.00907284646468e-08 NA NA NA hsa-miR-15a-5p PLD1 0.349521211668244 0.000770735998804736 -1.16313063789315 9.80903873525724e-10 MirTarget -0.380401161220259 2.87100002980444e-05 NA NA NA hsa-miR-32-3p PLD1 0.219109440121582 0.207217051619543 -1.16313063789315 9.80903873525724e-10 mirMAP -0.323216568494805 5.79568686466702e-09 NA NA NA hsa-miR-361-5p PLD1 0.233202959858696 0.00961572812255327 -1.16313063789315 9.80903873525724e-10 MirTarget;miRanda -0.546349921541104 1.99967621659251e-07 NA NA NA hsa-miR-374a-3p PLD1 -0.207171354826929 0.0623494608399903 -1.16313063789315 9.80903873525724e-10 MirTarget -0.244453974526287 0.00436706403835385 NA NA NA hsa-miR-374b-3p PLD1 -0.137420230218985 0.305318192448799 -1.16313063789315 9.80903873525724e-10 mirMAP -0.243103700943692 0.000607055622503843 NA NA NA hsa-miR-421 PLD1 0.941856334694081 6.12167297054077e-08 -1.16313063789315 9.80903873525724e-10 miRanda -0.163445356132813 0.00237837645921042 NA NA NA hsa-miR-664a-3p PLD1 0.485807855553031 0.000732553249798598 -1.16313063789315 9.80903873525724e-10 mirMAP -0.242144327959714 0.000215240480606375 NA NA NA hsa-miR-421 PSAT1 0.941856334694081 6.12167297054077e-08 -1.75596066319086 1.06148787244587e-14 miRanda -0.128289542772551 0.0493950703624296 NA NA NA hsa-miR-100-5p RPL31 -0.783576782126614 0.000219958772262677 0.190056636955827 0.108806633785031 miRNAWalker2_validate -0.129850287795012 1.2059360093415e-06 NA NA NA hsa-miR-16-5p RPL31 -0.398577235179603 0.000101598495180191 0.190056636955827 0.108806633785031 miRNAWalker2_validate -0.149366177809032 0.00806126452935342 NA NA NA hsa-miR-590-3p RPL31 -0.473167498047808 1.76652934637227e-05 0.190056636955827 0.108806633785031 miRanda;mirMAP -0.186132530957645 0.00035061277313087 NA NA NA hsa-miR-140-5p RPS16 -0.220106443070144 0.0140713197101242 0.440300344462681 0.000356870641587345 miRanda -0.231361107014312 0.00066834034378133 NA NA NA hsa-let-7a-5p RPS24 -0.328069937201898 0.000464344093744051 0.267883090577552 0.0468033270606586 miRNAWalker2_validate -0.335444955807039 1.57580782357663e-06 NA NA NA hsa-let-7b-5p RPS24 -0.959013717270803 5.95127281258643e-11 0.267883090577552 0.0468033270606586 miRNAWalker2_validate -0.231414526059271 9.27766409403112e-08 NA NA NA hsa-let-7c-5p RPS24 -1.70744661345097 2.87934212005942e-20 0.267883090577552 0.0468033270606586 miRNAWalker2_validate -0.196549606512263 3.44029551262791e-09 NA NA NA hsa-miR-16-5p RPS24 -0.398577235179603 0.000101598495180191 0.267883090577552 0.0468033270606586 miRNAWalker2_validate -0.231681235774775 0.000291425587332307 NA NA NA hsa-miR-26a-5p RPS24 -0.963792031426845 1.83360999387345e-22 0.267883090577552 0.0468033270606586 miRNAWalker2_validate -0.225255586797571 0.000376172048141598 NA NA NA hsa-miR-27a-3p RPS24 -0.370807380415112 0.00875721956202713 0.267883090577552 0.0468033270606586 miRNAWalker2_validate -0.101189487310556 0.0296690406683812 NA NA NA hsa-miR-491-5p RPS24 -0.369122930844418 0.0154047757048929 0.267883090577552 0.0468033270606586 miRanda -0.14918095994545 0.000591022140889338 NA NA NA