miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7c-5p ABCB9 -1.70744661345097 2.87934212005942e-20 1.00955603859492 1.63896842371547e-09 MirTarget -0.273859383833607 6.80741103254938e-11 NA NA NA hsa-let-7c-5p ABCC10 -1.70744661345097 2.87934212005942e-20 1.42399346571582 1.7634577339245e-36 MirTarget -0.301575187605271 5.72062761788124e-25 NA NA NA hsa-let-7c-5p ANKRD49 -1.70744661345097 2.87934212005942e-20 0.399680304237402 6.46826622613075e-08 MirTarget -0.100989362644086 4.78554482063786e-08 NA NA NA hsa-let-7c-5p BZW2 -1.70744661345097 2.87934212005942e-20 0.577245550489843 7.10575922293368e-08 MirTarget -0.203335965765395 1.43522953010322e-14 NA NA NA hsa-let-7c-5p CBX5 -1.70744661345097 2.87934212005942e-20 0.352720475583158 0.00158496538783418 MirTarget -0.117320573000309 2.65277493570271e-05 NA NA NA hsa-let-7c-5p CBX6 -1.70744661345097 2.87934212005942e-20 -0.135925898836227 0.562356772831778 miRNAWalker2_validate -0.147751255324137 0.0120748662714877 NA NA NA hsa-let-7c-5p CCNB2 -1.70744661345097 2.87934212005942e-20 4.23615330954301 1.17296327500891e-51 miRNAWalker2_validate -0.85447689630769 1.64053136609545e-30 NA NA NA hsa-let-7c-5p CCNF -1.70744661345097 2.87934212005942e-20 2.17480980282222 4.71512834823536e-34 miRNAWalker2_validate;MirTarget -0.504449149504788 2.14481709469935e-28 NA NA NA hsa-let-7c-5p CDC25A -1.70744661345097 2.87934212005942e-20 1.92057841155944 2.96621670231863e-18 MirTarget -0.51524439141821 8.99192957021977e-21 25909324 MicroRNA let 7c Inhibits Cell Proliferation and Induces Cell Cycle Arrest by Targeting CDC25A in Human Hepatocellular Carcinoma; The aim of the present study was to determine whether the cell cycle regulator CDC25A is involved in the antitumor effect of let-7c in HCC; The luciferase reporter assay showed that CDC25A was a direct target of let-7c and that let-7c inhibited the expression of CDC25A protein by directly targeting its 3' UTR; In conclusion this study indicates that let-7c suppresses HCC progression possibly by directly targeting the cell cycle regulator CDC25A and indirectly affecting its downstream target molecules progression liver cancer hsa-let-7c-5p CECR6 -1.70744661345097 2.87934212005942e-20 0.392226039618319 0.0399877472539567 MirTarget -0.145473456803039 0.00240190908970139 NA NA NA hsa-let-7c-5p CEP135 -1.70744661345097 2.87934212005942e-20 0.275453361086419 0.0378107269841227 MirTarget -0.128226314386056 0.000108910151993848 NA NA NA hsa-let-7c-5p CERCAM -1.70744661345097 2.87934212005942e-20 -0.11834200381201 0.648161793551643 MirTarget -0.138379572621477 0.0336460392243724 NA NA NA hsa-let-7c-5p CNOT3 -1.70744661345097 2.87934212005942e-20 0.579019484348105 2.78881715385032e-17 miRNAWalker2_validate -0.137147538185394 1.56310657094192e-15 NA NA NA hsa-let-7c-5p COL24A1 -1.70744661345097 2.87934212005942e-20 2.07152152023539 2.94685578585709e-08 MirTarget -0.322074263479633 0.000715997285583281 NA NA NA hsa-let-7c-5p CSNK2A1 -1.70744661345097 2.87934212005942e-20 0.311613292322925 6.17228757339028e-05 miRNAWalker2_validate -0.118081213291704 8.22763425873157e-10 NA NA NA hsa-let-7c-5p CYB561D1 -1.70744661345097 2.87934212005942e-20 1.35618855619484 4.53684308721849e-24 MirTarget -0.301970204704956 9.88527966067797e-19 NA NA NA hsa-let-7c-5p DAGLA -1.70744661345097 2.87934212005942e-20 1.16197262256378 7.56867119602314e-06 MirTarget -0.448159334629883 3.0762615596391e-12 NA NA NA hsa-let-7c-5p DCAF15 -1.70744661345097 2.87934212005942e-20 0.442903624361357 6.04251738050238e-08 MirTarget -0.101335020598812 8.14528075667905e-07 NA NA NA hsa-let-7c-5p DCLRE1B -1.70744661345097 2.87934212005942e-20 0.715031438649862 1.3174682860474e-13 MirTarget -0.114154467810837 3.88086854753268e-06 NA NA NA hsa-let-7c-5p DCTN5 -1.70744661345097 2.87934212005942e-20 0.109069264850494 0.145747375920191 miRNAWalker2_validate -0.137050765086275 4.53587636121251e-14 NA NA NA hsa-let-7c-5p DLGAP4 -1.70744661345097 2.87934212005942e-20 0.616384781844966 4.24155614328603e-13 MirTarget -0.178146649866821 2.96101504576869e-17 NA NA NA hsa-let-7c-5p DNAJC6 -1.70744661345097 2.87934212005942e-20 2.31761593888368 5.40782208875271e-21 miRNAWalker2_validate -0.383639320555159 2.04522452132374e-09 NA NA NA hsa-let-7c-5p DOT1L -1.70744661345097 2.87934212005942e-20 0.585703387018246 2.71031330751421e-07 miRNAWalker2_validate -0.149931329292625 1.58114052310453e-07 NA NA NA hsa-let-7c-5p DZIP1L -1.70744661345097 2.87934212005942e-20 -0.0817102374066513 0.728597088782924 MirTarget -0.153365860262585 0.00940939013868638 NA NA NA hsa-let-7c-5p E2F2 -1.70744661345097 2.87934212005942e-20 2.82262179260901 6.90997126839698e-33 MirTarget -0.605641654221748 3.1290897462579e-23 NA NA NA hsa-let-7c-5p E2F5 -1.70744661345097 2.87934212005942e-20 0.730554652437087 0.000401890915871585 MirTarget -0.228095461415917 1.04748751614991e-05 NA NA NA hsa-let-7c-5p ELF4 -1.70744661345097 2.87934212005942e-20 -0.129534848954421 0.489734019401336 MirTarget -0.135890153838811 0.0038215332500121 NA NA NA hsa-let-7c-5p ESPL1 -1.70744661345097 2.87934212005942e-20 1.87757313624794 3.45937181689806e-13 MirTarget -0.45417008213531 3.14084416633658e-12 NA NA NA hsa-let-7c-5p FAM103A1 -1.70744661345097 2.87934212005942e-20 0.489844961593656 1.4777880039426e-09 miRNAWalker2_validate -0.146424524120768 3.23230414839587e-13 NA NA NA hsa-let-7c-5p FAM104A -1.70744661345097 2.87934212005942e-20 0.382548867340036 2.14628142056169e-09 MirTarget -0.10225823892978 1.28559987604419e-10 NA NA NA hsa-let-7c-5p FANCI -1.70744661345097 2.87934212005942e-20 2.58883645204084 1.64497704333454e-42 miRNAWalker2_validate -0.553264627084958 3.44910425383123e-29 NA NA NA hsa-let-7c-5p FIGNL2 -1.70744661345097 2.87934212005942e-20 1.38863525177439 4.36348606427085e-07 MirTarget -0.440097760520244 1.38345498901364e-10 NA NA NA hsa-let-7c-5p FKBP10 -1.70744661345097 2.87934212005942e-20 0.164171258069953 0.48719948726372 miRNAWalker2_validate -0.199648875231396 0.00073149848136377 NA NA NA hsa-let-7c-5p GARS -1.70744661345097 2.87934212005942e-20 0.53606930447414 1.66438816977997e-09 miRNAWalker2_validate -0.161680244524281 2.42584352025334e-13 NA NA NA hsa-let-7c-5p GGA3 -1.70744661345097 2.87934212005942e-20 0.711679336404982 1.46861146142528e-21 MirTarget -0.172818653690179 3.02949988341581e-20 NA NA NA hsa-let-7c-5p GRPEL2 -1.70744661345097 2.87934212005942e-20 0.65712951992937 1.31065567027786e-19 MirTarget -0.166885706843202 3.33866025922138e-20 NA NA NA hsa-let-7c-5p GSK3A -1.70744661345097 2.87934212005942e-20 0.346560250550711 1.83266290443851e-08 miRNAWalker2_validate -0.101608466684152 2.71277295275603e-11 NA NA NA hsa-let-7c-5p HIF1AN -1.70744661345097 2.87934212005942e-20 0.594006229178836 2.59789157148843e-12 MirTarget -0.147609310389359 4.12097290603693e-12 NA NA NA hsa-let-7c-5p HMGA1 -1.70744661345097 2.87934212005942e-20 1.52957485940098 1.79164981120061e-17 MirTarget -0.517651637702838 1.10830470288536e-32 NA NA NA hsa-let-7c-5p HMGA2 -1.70744661345097 2.87934212005942e-20 1.11519648679255 0.015940340984894 miRNAWalker2_validate;miRTarBase;MirTarget -0.682135030438129 2.57681307834063e-09 NA NA NA hsa-let-7c-5p IGDCC3 -1.70744661345097 2.87934212005942e-20 1.93021594033306 4.85774469918296e-06 MirTarget -0.631731378965707 2.0749328122547e-09 NA NA NA hsa-let-7c-5p IGDCC4 -1.70744661345097 2.87934212005942e-20 1.73062068710294 1.15353341113415e-06 MirTarget -0.669489234913257 2.47646431218122e-14 NA NA NA hsa-let-7c-5p IGF2BP1 -1.70744661345097 2.87934212005942e-20 4.99826974747196 9.59227871105866e-16 MirTarget -1.64306107284158 3.32791048956517e-27 NA NA NA hsa-let-7c-5p IGF2BP2 -1.70744661345097 2.87934212005942e-20 1.1359757160287 0.0039471483972338 MirTarget -0.66967665441044 5.02308301505737e-12 NA NA NA hsa-let-7c-5p IGF2BP3 -1.70744661345097 2.87934212005942e-20 2.42884018072337 1.74029814218083e-12 MirTarget -0.792505127678787 9.55879338832913e-21 NA NA NA hsa-let-7c-5p IP6K1 -1.70744661345097 2.87934212005942e-20 0.889516693961123 4.04556190796781e-31 miRNAWalker2_validate -0.136554103095589 1.44616222053653e-11 NA NA NA hsa-let-7c-5p KCTD17 -1.70744661345097 2.87934212005942e-20 0.903379904615084 0.000443017892119058 MirTarget -0.481480851735286 2.15992968805401e-14 NA NA NA hsa-let-7c-5p KIAA1429 -1.70744661345097 2.87934212005942e-20 0.529087998279843 4.72515528254996e-10 MirTarget -0.12056072911504 1.72477615472835e-08 NA NA NA hsa-let-7c-5p KLHL31 -1.70744661345097 2.87934212005942e-20 1.26597140369387 1.58519014245934e-11 MirTarget -0.113451025803371 0.019099409616493 NA NA NA hsa-let-7c-5p LBR -1.70744661345097 2.87934212005942e-20 0.388685096070557 0.000119421752361692 MirTarget -0.180026392917426 3.89595826197494e-13 NA NA NA hsa-let-7c-5p LIMD2 -1.70744661345097 2.87934212005942e-20 -0.214037676050721 0.282021903246009 MirTarget -0.218360777157729 1.04445562421957e-05 NA NA NA hsa-let-7c-5p LIMK2 -1.70744661345097 2.87934212005942e-20 0.891712220823075 3.4499668982677e-09 MirTarget -0.236593103071651 4.17089447540952e-10 NA NA NA hsa-let-7c-5p LIN28B -1.70744661345097 2.87934212005942e-20 2.26854994708754 4.69141976850235e-05 MirTarget -0.942677952234562 8.19224435516587e-12 NA NA NA hsa-let-7c-5p MDFI -1.70744661345097 2.87934212005942e-20 1.613063811487 1.62996375672374e-07 MirTarget -0.449944709746608 5.78696252416618e-09 NA NA NA hsa-let-7c-5p MDM4 -1.70744661345097 2.87934212005942e-20 0.73357660128009 1.75853291398166e-12 MirTarget -0.16378523997819 4.65469630843185e-10 NA NA NA hsa-let-7c-5p MGAT4A -1.70744661345097 2.87934212005942e-20 0.104155687943847 0.347191347682603 MirTarget -0.139105957783091 3.9224788202799e-07 NA NA NA hsa-let-7c-5p NAP1L1 -1.70744661345097 2.87934212005942e-20 0.48873822323481 4.44413744556636e-06 MirTarget -0.248793874030014 2.70783118256391e-22 NA NA NA hsa-let-7c-5p NME6 -1.70744661345097 2.87934212005942e-20 0.606950484577572 4.34851975188018e-13 MirTarget -0.214598920327561 3.81766152781017e-26 NA NA NA hsa-let-7c-5p NPTX1 -1.70744661345097 2.87934212005942e-20 0.929025880461533 0.00584289763512414 miRNAWalker2_validate -0.349636575478964 3.44078587361936e-05 NA NA NA hsa-let-7c-5p NRARP -1.70744661345097 2.87934212005942e-20 0.806873954048561 5.97890763868229e-07 MirTarget -0.111854005713575 0.00649160992703926 NA NA NA hsa-let-7c-5p PAG1 -1.70744661345097 2.87934212005942e-20 -0.0641776217701535 0.737132600565642 MirTarget -0.11049170694399 0.0212818061791696 NA NA NA hsa-let-7c-5p PAK4 -1.70744661345097 2.87934212005942e-20 0.332066945941027 0.000554855795687645 miRNAWalker2_validate -0.146202847790971 7.66415471826461e-10 NA NA NA hsa-let-7c-5p PARD6B -1.70744661345097 2.87934212005942e-20 -0.0933903062942685 0.430333811242109 MirTarget -0.142218447562304 1.26822558335396e-06 NA NA NA hsa-let-7c-5p PCGF3 -1.70744661345097 2.87934212005942e-20 0.167536921370584 0.0398744101142924 miRNAWalker2_validate;MirTarget -0.113853768613945 1.4497220623856e-08 NA NA NA hsa-let-7c-5p PLAGL2 -1.70744661345097 2.87934212005942e-20 0.336986331692996 0.00300478705110513 MirTarget -0.167081915992385 2.69511671900005e-09 NA NA NA hsa-let-7c-5p PLEKHG6 -1.70744661345097 2.87934212005942e-20 0.0255008978984725 0.925472142399852 MirTarget -0.203069992909591 0.0029441217881029 NA NA NA hsa-let-7c-5p PLXND1 -1.70744661345097 2.87934212005942e-20 0.69765536803745 4.01395417482674e-09 MirTarget -0.121343527002517 5.62640054248759e-05 NA NA NA hsa-let-7c-5p PRAF2 -1.70744661345097 2.87934212005942e-20 0.470949457085433 4.21533714109916e-05 miRNAWalker2_validate -0.114609565008073 7.36690639861184e-05 NA NA NA hsa-let-7c-5p PRKAA2 -1.70744661345097 2.87934212005942e-20 0.910177606708893 0.0133266185680845 MirTarget -0.323478962357034 0.000457014156060023 NA NA NA hsa-let-7c-5p PRRX1 -1.70744661345097 2.87934212005942e-20 2.13747637731194 2.98162416691034e-16 MirTarget -0.352682612593982 1.66283334492681e-07 NA NA NA hsa-let-7c-5p PTGES2 -1.70744661345097 2.87934212005942e-20 0.505915263560095 4.3460926132534e-06 miRNAWalker2_validate -0.150018737330616 5.00669169745312e-08 NA NA NA hsa-let-7c-5p PTK2 -1.70744661345097 2.87934212005942e-20 0.592116034898139 1.42360483588582e-09 miRNAWalker2_validate -0.111526582483996 6.85487252665759e-06 NA NA NA hsa-let-7c-5p RAB11FIP4 -1.70744661345097 2.87934212005942e-20 1.54437373311846 7.02562100479325e-17 MirTarget -0.366743712732836 4.57221998622098e-15 NA NA NA hsa-let-7c-5p RAB34 -1.70744661345097 2.87934212005942e-20 0.412870987704762 0.126202873299987 miRNAWalker2_validate -0.284015184457008 2.48793947860605e-05 NA NA NA hsa-let-7c-5p RAD18 -1.70744661345097 2.87934212005942e-20 0.734804507433037 1.25694117049507e-15 MirTarget -0.162229147179546 3.03633151346655e-12 NA NA NA hsa-let-7c-5p RAPGEFL1 -1.70744661345097 2.87934212005942e-20 0.512757940233236 0.00610377319567469 miRNAWalker2_validate -0.104672283482989 0.0263816556863234 NA NA NA hsa-let-7c-5p RFWD3 -1.70744661345097 2.87934212005942e-20 0.435632342748586 1.3132101658858e-06 miRNAWalker2_validate -0.125524002210606 2.35908018598628e-08 NA NA NA hsa-let-7c-5p RFX5 -1.70744661345097 2.87934212005942e-20 1.21360829628678 2.49921334600813e-28 MirTarget -0.142572635491316 1.08560294572442e-06 NA NA NA hsa-let-7c-5p RPL18A -1.70744661345097 2.87934212005942e-20 0.302238061682566 0.0189119255010824 miRNAWalker2_validate -0.183702992224943 7.94319049679231e-09 NA NA NA hsa-let-7c-5p RPS13 -1.70744661345097 2.87934212005942e-20 0.0402954151984805 0.688921058276665 miRNAWalker2_validate -0.10218446432348 4.42586947280731e-05 NA NA NA hsa-let-7c-5p RPS24 -1.70744661345097 2.87934212005942e-20 0.267883090577552 0.0468033270606586 miRNAWalker2_validate -0.196549606512263 3.44029551262791e-09 NA NA NA hsa-let-7c-5p SEMA3F -1.70744661345097 2.87934212005942e-20 1.45777080905473 1.56816209923569e-37 MirTarget -0.234818872817101 1.05143991596871e-14 NA NA NA hsa-let-7c-5p SEMA4F -1.70744661345097 2.87934212005942e-20 1.01208582172754 6.47089148904579e-05 MirTarget -0.273087481441457 1.81190606874631e-05 NA NA NA hsa-let-7c-5p SF3B4 -1.70744661345097 2.87934212005942e-20 1.02312871885638 7.99127216761014e-26 miRNAWalker2_validate -0.218936273994718 1.52946844995903e-18 NA NA NA hsa-let-7c-5p SLC10A3 -1.70744661345097 2.87934212005942e-20 0.351752502448654 0.00188986179930041 miRNAWalker2_validate -0.182712057163013 5.67345250226885e-11 NA NA NA hsa-let-7c-5p SLC17A9 -1.70744661345097 2.87934212005942e-20 0.51327413401667 0.00962042525885391 MirTarget -0.198870581493571 6.13429852972486e-05 NA NA NA hsa-let-7c-5p SMARCC1 -1.70744661345097 2.87934212005942e-20 0.453331771984192 2.34444535272705e-08 miRNAWalker2_validate -0.12781175289705 2.68001045795896e-10 NA NA NA hsa-let-7c-5p SMARCD1 -1.70744661345097 2.87934212005942e-20 0.643238619401545 1.43047276243426e-17 miRNAWalker2_validate -0.177640467487771 1.94594245173065e-21 NA NA NA hsa-let-7c-5p SMCR8 -1.70744661345097 2.87934212005942e-20 0.453242799658724 3.50739679214307e-06 MirTarget -0.122565100231006 5.4902514084137e-07 NA NA NA hsa-let-7c-5p SOX13 -1.70744661345097 2.87934212005942e-20 0.713864896374115 5.5028190432502e-13 MirTarget -0.124273877815759 8.64473078600962e-07 NA NA NA hsa-let-7c-5p STX3 -1.70744661345097 2.87934212005942e-20 0.268625915502391 0.0620467313021486 MirTarget -0.200597820665899 1.7582165585329e-08 NA NA NA hsa-let-7c-5p SUB1 -1.70744661345097 2.87934212005942e-20 0.583706814960803 1.03979976716946e-11 MirTarget -0.151812387295251 1.54400818436745e-12 NA NA NA hsa-let-7c-5p TAZ -1.70744661345097 2.87934212005942e-20 0.956747824088997 5.51728917847337e-22 miRNAWalker2_validate -0.160843910434223 3.98057075434146e-10 NA NA NA hsa-let-7c-5p TBC1D13 -1.70744661345097 2.87934212005942e-20 0.861209565504011 9.70398365961959e-16 MirTarget -0.174153765242454 1.81958533488793e-10 NA NA NA hsa-let-7c-5p TBKBP1 -1.70744661345097 2.87934212005942e-20 0.916427652689533 7.35042591752853e-10 MirTarget -0.255902300442293 6.22257358099485e-12 NA NA NA hsa-let-7c-5p TMEM165 -1.70744661345097 2.87934212005942e-20 0.581530725593331 1.55109884568793e-08 miRNAWalker2_validate -0.144842845795178 2.038268418118e-08 NA NA NA hsa-let-7c-5p TMEM184B -1.70744661345097 2.87934212005942e-20 0.889593464258157 1.1912658512836e-19 miRNAWalker2_validate -0.170532146688534 1.19223629021959e-11 NA NA NA hsa-let-7c-5p TRIM67 -1.70744661345097 2.87934212005942e-20 0.526474972444801 0.0261906603203476 MirTarget -0.221979298256235 0.000181660256380273 NA NA NA hsa-let-7c-5p TRIM71 -1.70744661345097 2.87934212005942e-20 1.88705329759216 3.31797883877253e-06 miRNAWalker2_validate;MirTarget -0.78785120052045 2.91205218598371e-15 NA NA NA hsa-let-7c-5p TTLL4 -1.70744661345097 2.87934212005942e-20 1.09772685973996 1.47068858470308e-10 MirTarget -0.450426278450796 7.57793283588566e-28 NA NA NA hsa-let-7c-5p UBA52 -1.70744661345097 2.87934212005942e-20 0.28393248928586 0.0110134022626622 miRNAWalker2_validate -0.106594975606236 0.000134675405654401 NA NA NA hsa-let-7c-5p ZC3H3 -1.70744661345097 2.87934212005942e-20 1.0612730707833 1.57569638197004e-20 MirTarget -0.199043730435108 1.27659419619969e-11 NA NA NA hsa-let-7c-5p ZNF512B -1.70744661345097 2.87934212005942e-20 0.949756749303405 1.79541489585724e-18 MirTarget -0.178134616117144 1.43198078159576e-10 NA NA NA hsa-let-7c-5p ZNF526 -1.70744661345097 2.87934212005942e-20 0.694364272257119 1.11242011006087e-21 miRNAWalker2_validate -0.147571959257241 1.3126555892882e-15 NA NA NA hsa-let-7c-5p ZNF581 -1.70744661345097 2.87934212005942e-20 1.08114010713937 1.93294426178797e-17 miRNAWalker2_validate -0.315580993313553 1.10992003321011e-23 NA NA NA hsa-let-7c-5p ZNF710 -1.70744661345097 2.87934212005942e-20 0.313248196006383 0.103373907581206 MirTarget -0.120535446215635 0.0125911174137927 NA NA NA