miRNA	gene	miRNA_log2FC	miRNA_pvalue	gene_log2FC	gene_pvalue	interactions	correlation_beta	correlation_pvalue	PMID	evidence	outcome	cancer
hsa-miR-148a-5p	CD44	1.16173838132242	0.000148929299881612	-0.796526651909205	0.0427559627960533	mirMAP	-0.184693372477928	0.00280500362000093	23861222	In MHCC97H and MHCC97L cells over-expression of miR-148a blocked the EMT process attenuated the expression of CD90 and CD44 biomarkers for liver cancer stem cells and inhibited their migratory capacity		liver cancer
hsa-miR-15b-5p	CD44	1.57112623124278	9.14247846750597e-13	-0.796526651909205	0.0427559627960533	miRNAWalker2_validate	-0.447526802339096	9.12256284724987e-08		NA	NA	NA
hsa-miR-16-5p	CD44	1.75824877145857	1.68592440033108e-16	-0.796526651909205	0.0427559627960533	miRNAWalker2_validate	-0.230625961296894	0.00778893359877255		NA	NA	NA
hsa-miR-181a-2-3p	CD44	2.19062681262366	3.81790102612782e-13	-0.796526651909205	0.0427559627960533	MirTarget	-0.228096134984064	0.000193690082473942		NA	NA	NA
hsa-miR-185-5p	CD44	2.34016206907488	1.17481626642022e-26	-0.796526651909205	0.0427559627960533	MirTarget	-0.365105727396741	7.52346556220384e-06		NA	NA	NA
hsa-miR-28-5p	CD44	0.230152919654905	0.0742909586754846	-0.796526651909205	0.0427559627960533	miRanda	-0.917439364317955	9.13749604227941e-10		NA	NA	NA
hsa-miR-30e-3p	CD44	-0.215663037684509	0.235375122783546	-0.796526651909205	0.0427559627960533	mirMAP	-0.790970349895941	1.75570512558694e-14		NA	NA	NA
hsa-miR-320a	CD44	0.438165828017084	0.0390159073347133	-0.796526651909205	0.0427559627960533	miRNAWalker2_validate	-0.270789976894063	0.00271905181476129		NA	NA	NA
hsa-miR-326	CD44	0.715313016136042	0.0610265683213359	-0.796526651909205	0.0427559627960533	miRanda	-0.347899847622553	1.02699780402226e-12		NA	NA	NA
hsa-miR-328-3p	CD44	0.596804159297544	0.013858523511843	-0.796526651909205	0.0427559627960533	miRNAWalker2_validate;miRTarBase	-0.386675085611228	7.19138603194367e-07		NA	NA	NA
hsa-miR-330-3p	CD44	0.876747334239085	0.00073709016089703	-0.796526651909205	0.0427559627960533	miRNAWalker2_validate;miRTarBase	-0.400115502634685	3.07400539078329e-08		NA	NA	NA
hsa-miR-330-5p	CD44	1.15100069700871	4.85551805046014e-07	-0.796526651909205	0.0427559627960533	miRanda	-0.234747247689746	0.00452352423556939		NA	NA	NA
hsa-miR-33a-3p	CD44	1.72765312072219	1.51784443453521e-07	-0.796526651909205	0.0427559627960533	mirMAP	-0.385531577314183	3.97985384939592e-10		NA	NA	NA
hsa-miR-34a-5p	CD44	1.9016323452565	1.43092834643601e-14	-0.796526651909205	0.0427559627960533	miRNAWalker2_validate;miRTarBase	-0.275230949000913	0.000227008858457591	25572695;24423412;25551284;25044638;21240262;26231042;27497057;23314380	The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;Furthermore we identified CD44 as being targeted by miR-34a in MIBC cells following cisplatin treatment and increased CD44 expression could efficiently reverse the effect of miR-34a on MIBC cell proliferation colongenic potential and chemosensitivity; Cisplatin-based chemotherapy induced demethylation of miR-34a promoter and increased miR-34a expression which in turn sensitized MIBC cells to cisplatin and decreased the tumorigenicity and proliferation of cancer cells that by reducing the production of CD44;MicroRNA 34a functions as an anti metastatic microRNA and suppresses angiogenesis in bladder cancer by directly targeting CD44; In this study we focus on it that microRNA-34a functions as an anti-metastatic microRNA and suppress angiogenesis in bladder cancer by directly targeting CD44; Our study defines a major metastasis and angiogenesis suppressive role for mir-34a a microRNA functions as a tumor suppressor in bladder cancer by directly targeting CD44 which would be helpful as a therapeutic approach to block bladder cancer metastasis;Nanocomplex-assisted delivery of miR-34a induces cell apoptosis and suppresses migration proliferation and tumor growth of breast cancer cells via targeting CD44 and a Notch-1-signaling pathway;The microRNA miR 34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44; We identified and validated CD44 as a direct and functional target of miR-34a and found that CD44 knockdown phenocopied miR-34a overexpression in inhibiting prostate cancer regeneration and metastasis;Registered report: the microRNA miR 34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44; Tumors with exogenous miR-34a showed reduced levels of CD44 expression Figure 4A and mutation of two putative miR-34a binding sites in the CD33 3' UTR partially abrogated signal repression in a luciferase assay Figure 4D;Nanovesicle mediated systemic delivery of microRNA 34a for CD44 overexpressing gastric cancer stem cell therapy; MicroRNA-34a miR-34a is a promising candidate for CD44 repression-based cancer therapy as it has been reported to inhibit proliferation metastasis and survival of CD44-positive CSCs; Here we used nanovesicles containing PLI/miR complexes NVs/miR to systemically deliver miR-34a and induce miR-34a-triggered CD44 suppression in orthotopically and subcutaneously implanted tumors in nude mice;miR 34a inhibits the metastasis of osteosarcoma cells by repressing the expression of CD44; The ectopic overexpression of miR-34a significantly inhibited the migration and invasive ability of osteosarcoma cells by repressing the expression of CD44; These data suggest that miR-34a plays a tumor suppressor role in the metastasis of osteosarcoma cells by repressing the expression of CD44; Therefore it can be concluded that through the inhibition of CD44 expression levels miR-34a plays a significant role in the migration and invasion of osteosarcoma cells	;;metastasis;;metastasis;metastasis;metastasis;poor survival;metastasis	bladder cancer;bladder cancer;bladder cancer;breast cancer;prostate cancer;prostate cancer;gastric cancer;sarcoma
hsa-miR-421	CD44	1.17791565395543	6.78526676976629e-06	-0.796526651909205	0.0427559627960533	miRanda	-0.368683289724633	2.69362557967671e-07		NA	NA	NA
hsa-miR-532-3p	CD44	1.96631878320218	4.53421954361695e-13	-0.796526651909205	0.0427559627960533	miRNATAP	-0.442544677928769	3.69356749912527e-11		NA	NA	NA
hsa-miR-590-3p	CD44	2.59289455139753	1.03200520972022e-21	-0.796526651909205	0.0427559627960533	MirTarget;miRanda;miRNATAP	-0.169901950349398	0.0136933797557165		NA	NA	NA
hsa-miR-744-5p	CD44	1.48254348878737	3.23019501613577e-09	-0.796526651909205	0.0427559627960533	miRNAWalker2_validate	-0.463511714400314	2.9614674442169e-10		NA	NA	NA
hsa-miR-942-5p	CD44	2.35195531153712	5.45059325728841e-16	-0.796526651909205	0.0427559627960533	MirTarget	-0.133468572154989	0.0355715456391667		NA	NA	NA