miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7a-5p AIFM1 -1.37014061604018 3.11451492971224e-14 0.701046679657264 4.73210836532952e-09 TargetScan;miRNATAP -0.113097819095147 0.000177982745708989 NA NA NA hsa-let-7b-5p AIFM1 -1.62016148171663 1.56547487335694e-15 0.701046679657264 4.73210836532952e-09 miRNATAP -0.12394893444617 2.99656873665416e-06 NA NA NA hsa-let-7a-5p AKT2 -1.37014061604018 3.11451492971224e-14 0.158500088541505 0.113504798741429 TargetScan -0.119930037553526 1.13227688326527e-06 NA NA NA hsa-miR-29a-3p AKT2 0.101650412194573 0.573201097011668 0.158500088541505 0.113504798741429 MirTarget -0.104368014677354 4.26511869332683e-05 24076586 Furthermore a feed-back loop comprising of c-Myc miR-29 family and Akt2 were found in myeloid leukemogenesis acute myeloid leukemia hsa-miR-106b-5p AKT3 1.47447672652218 1.32004094930462e-13 -1.44031241124732 2.576504600149e-09 miRNATAP -0.158920731526324 0.00425859940487133 NA NA NA hsa-miR-107 AKT3 0.658676029898313 5.11480446318819e-07 -1.44031241124732 2.576504600149e-09 PITA;miRanda -0.256548300142307 0.00309702957622585 NA NA NA hsa-miR-146b-5p AKT3 1.0922867893808 5.63754607494775e-06 -1.44031241124732 2.576504600149e-09 miRNAWalker2_validate -0.14508398550335 0.00188822517544197 NA NA NA hsa-miR-15a-5p AKT3 1.62575353599172 1.55312121019827e-19 -1.44031241124732 2.576504600149e-09 miRNAWalker2_validate;miRTarBase;miRNATAP -0.412918804091755 4.08840965026726e-12 NA NA NA hsa-miR-16-5p AKT3 0.749619098384047 4.11649450706988e-06 -1.44031241124732 2.576504600149e-09 miRNAWalker2_validate;miRTarBase;miRNATAP -0.269698520974258 9.94440318719177e-05 NA NA NA hsa-miR-17-3p AKT3 1.36706429551147 4.60388403547821e-13 -1.44031241124732 2.576504600149e-09 miRNATAP -0.150903286752378 0.0102655088674849 NA NA NA hsa-miR-17-5p AKT3 2.07078488653279 2.77403038572568e-19 -1.44031241124732 2.576504600149e-09 TargetScan;miRNATAP -0.217476886844258 3.56953935954486e-06 NA NA NA hsa-miR-181a-5p AKT3 -0.375429731222937 0.0562142867129802 -1.44031241124732 2.576504600149e-09 miRNATAP -0.22550600060725 9.19470016250579e-05 NA NA NA hsa-miR-181b-5p AKT3 0.668793269169928 0.000239998092406404 -1.44031241124732 2.576504600149e-09 miRNATAP -0.367498754199467 2.09865276667175e-09 NA NA NA hsa-miR-20a-5p AKT3 2.64649625616975 5.1469418982085e-27 -1.44031241124732 2.576504600149e-09 miRNATAP -0.24430728120197 1.27608550819212e-08 NA NA NA hsa-miR-22-3p AKT3 1.42501909916631 1.72295005910055e-25 -1.44031241124732 2.576504600149e-09 miRNATAP -0.259390140878921 0.0010937362716222 NA NA NA hsa-miR-28-3p AKT3 0.387144500601444 0.00777919765254534 -1.44031241124732 2.576504600149e-09 miRNATAP -0.197315516871575 0.0122556173898666 NA NA NA hsa-miR-29a-3p AKT3 0.101650412194573 0.573201097011668 -1.44031241124732 2.576504600149e-09 miRNATAP -0.147280324253872 0.0201558550795979 NA NA NA hsa-miR-29b-2-5p AKT3 0.345881055247341 0.194842633194187 -1.44031241124732 2.576504600149e-09 mirMAP -0.181342398720756 1.80199534450665e-05 NA NA NA hsa-miR-29b-3p AKT3 3.10527711861309 3.01242507282711e-32 -1.44031241124732 2.576504600149e-09 miRNATAP -0.267243460090773 1.17871192498365e-11 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-3065-5p AKT3 0.653308707552535 0.0999497219778851 -1.44031241124732 2.576504600149e-09 mirMAP -0.18242132898273 2.34990243224026e-09 NA NA NA hsa-miR-335-3p AKT3 1.51116383169018 6.88553098788624e-13 -1.44031241124732 2.576504600149e-09 mirMAP -0.134576700675304 0.0106735082003925 NA NA NA hsa-miR-362-5p AKT3 0.658947634569393 0.0243306847205756 -1.44031241124732 2.576504600149e-09 PITA;TargetScan;miRNATAP -0.229571357984291 4.43564207755877e-09 NA NA NA hsa-miR-542-3p AKT3 1.62226640768239 2.6427102465476e-10 -1.44031241124732 2.576504600149e-09 miRanda -0.186790699816246 1.44501888663791e-05 NA NA NA hsa-miR-93-5p AKT3 1.50844106515467 1.83836866996875e-12 -1.44031241124732 2.576504600149e-09 miRNATAP -0.251105283811718 1.01733106411986e-06 NA NA NA hsa-miR-23a-3p APAF1 0.111958289789488 0.393086414480463 0.0527330819081095 0.628296064246439 miRNATAP -0.131163580903016 0.000690306154175996 24992592;24249161 Luciferase assay was performed to verify a putative target site of miR-23a in the 3'-UTR of apoptosis protease activating factor 1 APAF1 mRNA; The expression levels of miR-23a and APAF1 in CRC cell lines SW480 and SW620 and clinical samples were assessed using reverse transcription-quantitative real-time PCR RT-qPCR and Western blot; Moreover miR-23a up-regulation was coupled with APAF1 down-regulation in CRC tissue samples;We found that the expression of miR-23a was increased and the level of apoptosis-activating factor-1 APAF-1 was decreased in 5-FU-treated colon cancer cells compared to untreated cells; APAF-1 as a target gene of miR-23a was identified and miR-23a antisense-induced increase in the activation of caspase-9 was observed ; colorectal cancer;colorectal cancer hsa-miR-23b-3p APAF1 -0.070273068040148 0.620585267977425 0.0527330819081095 0.628296064246439 miRNATAP -0.109314526987903 0.00215543348816896 NA NA NA hsa-miR-27a-3p APAF1 0.433402568013802 0.00737164631768323 0.0527330819081095 0.628296064246439 miRNATAP -0.16468480576707 8.19227183327682e-08 NA NA NA hsa-miR-27b-3p APAF1 0.236438984240408 0.12263510345883 0.0527330819081095 0.628296064246439 miRNATAP -0.166392707369462 3.36486831782177e-07 NA NA NA hsa-miR-664a-3p APAF1 0.443077463053857 0.0214248925850984 0.0527330819081095 0.628296064246439 mirMAP -0.111814656754016 1.51855061714124e-05 NA NA NA hsa-miR-15a-5p BCL2 1.62575353599172 1.55312121019827e-19 -0.487496069869486 0.0642113742980754 miRNAWalker2_validate;miRTarBase -0.187458177651156 0.00400964703367561 26915294;25594541;18931683;25623762;22335947 As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2;miR 15a and miR 16 modulate drug resistance by targeting bcl 2 in human colon cancer cells; To investigate the reversal effect of targeted modulation of bcl-2 expression by miR-15a and miR-16 on drug resistance of human colon cancer cells;The expression of MiR-15a was significantly inhibited by Bcl-2 P < 0.05 poor survival;;;drug resistance; lung cancer;breast cancer;prostate cancer;colon cancer;breast cancer hsa-miR-17-5p BCL2 2.07078488653279 2.77403038572568e-19 -0.487496069869486 0.0642113742980754 miRNAWalker2_validate;miRTarBase -0.116338876463301 0.0217440105866914 25435430 Combined overexpression of miR-16 and miR-17 greatly reduced Beclin-1 and Bcl-2 expressions respectively; miR-17 overexpression reduced cytoprotective autophagy by targeting Beclin-1 whereas overexpression of miR-16 potentiated paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2 lung cancer hsa-miR-200c-3p BCL2 0.380533388300368 0.0842181838538353 -0.487496069869486 0.0642113742980754 miRNAWalker2_validate;miRTarBase;mirMAP -0.126651991360998 0.022049998757799 NA NA NA hsa-miR-20a-3p BCL2 2.51803599558247 4.92479325298629e-13 -0.487496069869486 0.0642113742980754 mirMAP -0.102394535742893 0.0197408442233094 NA NA NA hsa-miR-20a-5p BCL2 2.64649625616975 5.1469418982085e-27 -0.487496069869486 0.0642113742980754 miRNAWalker2_validate;miRTarBase -0.115004935478343 0.0136833763472092 NA NA NA hsa-miR-21-5p BCL2 4.38165933891779 1.52536633902505e-92 -0.487496069869486 0.0642113742980754 miRNAWalker2_validate;miRTarBase -0.204010104736014 8.81514964878011e-06 22964582;21468550;25994220;25381586;26555418;23359184;21376256 Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;BCL-2 up-regulation could be achieved by miR-21 overexpression which prevented T24 cells from apoptosis induced by doxorubicin; Furthermore the miR-21 induced BCL-2 up-regulation could be cancelled by the PI3K inhibitor LY294002;Meanwhile miR-21 loss reduced STAT3 and Bcl-2 activation causing an increase in the apoptosis of tumour cells in CAC mice;Changes in the sensitivity of osteosarcoma cells to CDDP were examined after transfection with miR-21 mimics or anti-miR-21 or bcl-2 siRNA in combination with CDDP;The expression of Bax Bcl-2 and miR-21 in parental and paclitaxel-resistant cells was detected by RT-PCR and Western blotting;Resveratrol induces apoptosis of pancreatic cancers cells by inhibiting miR 21 regulation of BCL 2 expression; We also used Western blot to measure BCL-2 protein levels after down-regulation of miR-21 expression; Besides down-regulation of miR-21 expression can inhibit BCL-2 expression in PANC-1 CFPAC-1 and MIA Paca-2 cells; Over-expression of miR-21 expression can reverse down-regulation of BCL-2 expression and apoptosis induced by resveratrol; In this study we demonstrated that the effect of resveratrol on apoptosis is due to inhibiting miR-21 regulation of BCL-2 expression;Bcl 2 upregulation induced by miR 21 via a direct interaction is associated with apoptosis and chemoresistance in MIA PaCa 2 pancreatic cancer cells; However the roles and mechanisms of miRNA miR-21 in regulation of Bcl-2 in pancreatic cancer remain to be elucidated; Then luciferase activity was observed after miR-21 mimics and pRL-TK plasmids containing wild-type and mutant 3'UTRs of Bcl-2 mRNA were co-transfected; Cells transfected with miR-21 inhibitor revealed an opposite trend. There was a significant increase in luciferase activity in the cells transfected with the wild-type pRL-TK plasmid in contrast to those transfected with the mutant one indicating that miR-21 promotes Bcl-2 expression by binding directly to the 3'UTR of Bcl-2 mRNA; Upregulation of Bcl-2 directly induced by miR-21 is associated with apoptosis chemoresistance and proliferation of MIA PaCa-2 pancreatic cancer cells ;;;;;;drug resistance lung cancer;bladder cancer;colorectal cancer;sarcoma;breast cancer;pancreatic cancer;pancreatic cancer hsa-miR-224-5p BCL2 1.9183903633152 3.22216766330296e-06 -0.487496069869486 0.0642113742980754 mirMAP -0.138108415745186 1.72321765526623e-06 24796455 In addition the expressions of Bcl2 mRNA and protein were 1.05 ± 0.04 and 0.21 ± 0.03 in the miR-224 ASO group significantly lower than that in the control group 4.87 ± 0.96 and 0.88 ± 0.09 P < 0.01 gastric cancer hsa-miR-24-2-5p BCL2 1.43704663046967 4.34375016509278e-11 -0.487496069869486 0.0642113742980754 miRNAWalker2_validate;miRTarBase -0.15947750861285 0.00351654011349327 NA NA NA hsa-miR-29a-5p BCL2 1.89519956688438 1.03453349363915e-11 -0.487496069869486 0.0642113742980754 mirMAP -0.237477310346695 2.67918561276733e-06 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29 liver cancer hsa-miR-3065-5p BCL2 0.653308707552535 0.0999497219778851 -0.487496069869486 0.0642113742980754 mirMAP -0.121892398301854 0.000231812969788831 NA NA NA hsa-miR-34a-5p BCL2 1.40588612517769 8.60097477768592e-12 -0.487496069869486 0.0642113742980754 miRNAWalker2_validate;miRTarBase -0.185078875528925 0.00135283473559727 22964582;24565525;23155233;24444609;20687223;22623155;24988056;18803879;19714243;25053345;20433755;21399894;23862748 Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;In vitro and in vivo experiments showed that miR-34a and DOX can be efficiently encapsulated into HA-CS NPs and delivered into tumor cells or tumor tissues and enhance anti-tumor effects of DOX by suppressing the expression of non-pump resistance and anti-apoptosis proto-oncogene Bcl-2;The miR-34a expression levels in cells after irradiation at 30 and 60 Gy were 0.17- and 18.7-times the BCL2 and caspase-9 expression levels respectively;Functional analyses further indicate that restoration of miR-34a inhibits B cell lymphoma-2 Bcl-2 protein expression to withdraw the survival advantage of these resistant NSCLC cells;Thus in PC3PR cells reduced expression of miR-34a confers paclitaxel resistance via up-regulating SIRT1 and Bcl2 expression; MiR-34a and its downstream targets SIRT1 and Bcl2 play important roles in the development of paclitaxel resistance all of which can be useful biomarkers and promising therapeutic targets for the drug resistance in hormone-refractory prostate cancer;MiR 34a inhibits proliferation and migration of breast cancer through down regulation of Bcl 2 and SIRT1; In this study we aimed to determine the effect of miR-34a on the growth of breast cancer and to investigate whether its effect is achieved by targeting Bcl-2 and SIRT1; Bcl-2 and SIRT1 as the targets of miR-34a were found to be in reverse correlation with ectopic expression of miR-34a;Target analysis indicated that micro RNA miR-34a directly regulates Bcl-2 and miR-34a overexpression decreased Bcl-2 protein level in gastric cancer cells; We also found that luteolin upregulates miR-34a expression and downregulates Bcl-2 expression; Based on these results we can draw the conclusion that luteolin partly decreases Bcl-2 expression through upregulating miR-34a expression;miR-34 targets Notch HMGA2 and Bcl-2 genes involved in the self-renewal and survival of cancer stem cells; Human gastric cancer cells were transfected with miR-34 mimics or infected with the lentiviral miR-34-MIF expression system and validated by miR-34 reporter assay using Bcl-2 3'UTR reporter; Human gastric cancer Kato III cells with miR-34 restoration reduced the expression of target genes Bcl-2 Notch and HMGA2; Bcl-2 3'UTR reporter assay showed that the transfected miR-34s were functional and confirmed that Bcl-2 is a direct target of miR-34; The mechanism of miR-34-mediated suppression of self-renewal appears to be related to the direct modulation of downstream targets Bcl-2 Notch and HMGA2 indicating that miR-34 may be involved in gastric cancer stem cell self-renewal/differentiation decision-making;Among the target proteins regulated by miR-34 are Notch pathway proteins and Bcl-2 suggesting the possibility of a role for miR-34 in the maintenance and survival of cancer stem cells; Our data support the view that miR-34 may be involved in pancreatic cancer stem cell self-renewal potentially via the direct modulation of downstream targets Bcl-2 and Notch implying that miR-34 may play an important role in pancreatic cancer stem cell self-renewal and/or cell fate determination;Manipulating miR-34a in prostate cancer cells confirms that this miRNA regulates BCL-2 and may in part regulate response to docetaxel;For instance miR-34a up-regulation corresponded with a down-regulation of BCL2 protein; Treating Par-4-overexpressing HT29 cells with a miR-34a antagomir functionally reversed both BCL2 down-regulation and apoptosis by 5-FU;Quantitative PCR and western analysis confirmed decreased expression of two genes BCL-2 and CCND1 in docetaxel-resistant cells which are both targeted by miR-34a;MicroRNA 34a targets Bcl 2 and sensitizes human hepatocellular carcinoma cells to sorafenib treatment; HCC tissues with lower miR-34a expression displayed higher expression of Bcl-2 protein than those with high expression of miR-34a; therefore an inverse correlation is evident between the miR-34a level and Bcl-2 expression; Bioinformatics and luciferase reporter assays revealed that miR-34a binds the 3'-UTR of the Bcl-2 mRNA and represses its translation; Western blotting analysis and qRT-PCR confirmed that Bcl-2 is inhibited by miR-34a overexpression; Functional analyses indicated that the restoration of miR-34a reduced cell viability promoted cell apoptosis and potentiated sorafenib-induced apoptosis and toxicity in HCC cell lines by inhibiting Bcl-2 expression ;drug resistance;;poor survival;drug resistance;;;poor survival;differentiation;poor survival;drug resistance;;; lung cancer;breast cancer;glioblastoma;lung squamous cell cancer;prostate cancer;breast cancer;gastric cancer;gastric cancer;pancreatic cancer;prostate cancer;colon cancer;breast cancer;liver cancer hsa-miR-365a-3p BCL2 0.0132777124336201 0.953597412537431 -0.487496069869486 0.0642113742980754 miRNAWalker2_validate;miRTarBase -0.135798592942671 0.0110668436109814 NA NA NA hsa-miR-450b-5p BCL2 1.69248953402469 1.96052058003353e-07 -0.487496069869486 0.0642113742980754 mirMAP -0.19720389328785 1.37276161625093e-06 NA NA NA hsa-miR-452-5p BCL2 0.637123950346362 0.0458173998136196 -0.487496069869486 0.0642113742980754 mirMAP -0.123489150343591 0.00113373620964249 NA NA NA hsa-miR-542-3p BCL2 1.62226640768239 2.6427102465476e-10 -0.487496069869486 0.0642113742980754 mirMAP -0.191093289471344 3.49857445479472e-05 NA NA NA hsa-miR-590-3p BCL2 0.83851360565783 0.00129224433453587 -0.487496069869486 0.0642113742980754 miRanda;mirMAP -0.123434669030393 0.0270457405646397 NA NA NA hsa-miR-590-5p BCL2 2.07441240363458 4.95240551694843e-14 -0.487496069869486 0.0642113742980754 miRanda -0.183833993408744 0.000541716198465799 NA NA NA hsa-miR-96-5p BCL2 3.0381097138467 4.40362891630201e-24 -0.487496069869486 0.0642113742980754 miRNAWalker2_validate;TargetScan -0.137358301513432 0.0019288325262615 NA NA NA hsa-miR-500a-5p BIRC2 0.648155655714409 0.0104657432932038 -0.0566424270372563 0.620255875001944 MirTarget -0.112472951411246 8.53911662639019e-08 NA NA NA hsa-miR-24-1-5p BIRC3 0.856025727237819 0.000107354490323658 0.125427105924507 0.676483616271283 MirTarget -0.206759039423342 0.0016525543606198 NA NA NA hsa-miR-375 BIRC3 0.615547997686534 0.149199273675144 0.125427105924507 0.676483616271283 miRNAWalker2_validate -0.195933533083944 7.50694584162728e-10 23726271 Taken together these data suggest that miR-375 sensitizes TNF-α-induced apoptosis and the reduction in the expression of the apoptosis inhibitory proteins cFLIP-L and cIAP2 plays an important role in this sensitization head and neck cancer hsa-miR-664a-3p BIRC3 0.443077463053857 0.0214248925850984 0.125427105924507 0.676483616271283 mirMAP -0.16585436385996 0.0215980202864507 NA NA NA hsa-miR-98-5p BIRC3 1.170602085804 1.09900501665229e-08 0.125427105924507 0.676483616271283 miRNAWalker2_validate -0.135956769299651 0.0476049079151008 NA NA NA hsa-miR-107 CAPN2 0.658676029898313 5.11480446318819e-07 -0.307487246393565 0.0517639236874996 miRanda -0.129487592988861 0.020246847954034 NA NA NA hsa-miR-16-2-3p CAPN2 0.503964803530872 0.0263648405197492 -0.307487246393565 0.0517639236874996 mirMAP -0.11004591764374 0.00157478022798458 NA NA NA hsa-miR-20a-3p CAPN2 2.51803599558247 4.92479325298629e-13 -0.307487246393565 0.0517639236874996 MirTarget -0.126718135438292 1.16532550012936e-06 NA NA NA hsa-miR-320b CAPN2 0.226640952564488 0.378818692487242 -0.307487246393565 0.0517639236874996 miRanda -0.123991691232165 1.04526537750598e-05 NA NA NA hsa-miR-421 CAPN2 0.170525317701774 0.535277026680289 -0.307487246393565 0.0517639236874996 miRanda -0.157545501874524 3.03052816875822e-08 NA NA NA hsa-miR-590-5p CAPN2 2.07441240363458 4.95240551694843e-14 -0.307487246393565 0.0517639236874996 miRanda -0.160886327978009 3.58492015382408e-07 NA NA NA hsa-miR-148b-5p CASP10 1.39335695292409 2.13220380550073e-07 -0.273124939830875 0.0980559181398398 mirMAP -0.142918818215108 1.84018593774494e-05 NA NA NA hsa-miR-19a-3p CASP10 2.11776595911517 7.07663078397156e-10 -0.273124939830875 0.0980559181398398 MirTarget;mirMAP -0.103748849625307 5.82215966866069e-05 NA NA NA hsa-miR-19b-1-5p CASP10 1.71217036351784 3.28561659177495e-12 -0.273124939830875 0.0980559181398398 mirMAP -0.180380873043991 1.8051624722446e-07 NA NA NA hsa-miR-19b-3p CASP10 2.10868505662119 5.40846613768389e-17 -0.273124939830875 0.0980559181398398 MirTarget;mirMAP -0.117954936938626 0.000117554430485811 NA NA NA hsa-miR-421 CASP10 0.170525317701774 0.535277026680289 -0.273124939830875 0.0980559181398398 mirMAP -0.173186299099511 5.10535452071279e-09 NA NA NA hsa-miR-744-3p CASP10 2.07439104592565 3.30645434602132e-12 -0.273124939830875 0.0980559181398398 mirMAP -0.132075541742933 7.93996713929531e-08 NA NA NA hsa-miR-139-5p CASP3 -2.26625553116965 7.22375119369519e-16 0.749868979708077 8.30799302647668e-11 miRanda -0.103400450602475 1.92824413318983e-08 NA NA NA hsa-miR-195-3p CASP3 -1.33068822339418 6.65427393047357e-09 0.749868979708077 8.30799302647668e-11 MirTarget -0.12156615230384 1.38560895801409e-07 NA NA NA hsa-miR-30c-5p CASP3 -0.327319105755825 0.123595832152687 0.749868979708077 8.30799302647668e-11 miRNATAP -0.14954468041522 2.8553699558622e-09 NA NA NA hsa-miR-30d-5p CASP3 -0.920901858717441 3.50898334321668e-05 0.749868979708077 8.30799302647668e-11 miRNAWalker2_validate;miRTarBase;miRNATAP -0.173377620122409 2.06657661969359e-13 NA NA NA hsa-miR-125a-5p CASP6 -1.04824536696301 3.97386082850476e-07 0.904444256335095 7.02954024495495e-11 miRanda -0.117486960142462 0.000160301516487637 NA NA NA hsa-miR-664a-3p CASP7 0.443077463053857 0.0214248925850984 -0.211288307918442 0.0813860667885838 MirTarget -0.108240210919283 0.000181784451993205 NA NA NA hsa-miR-107 CFLAR 0.658676029898313 5.11480446318819e-07 -0.60264981549415 0.000146924534874046 miRanda -0.150916593963368 0.00732127376323208 NA NA NA hsa-miR-130b-3p CFLAR 1.83046548750752 5.04753914574694e-13 -0.60264981549415 0.000146924534874046 mirMAP -0.170030964912425 7.49012425842225e-09 NA NA NA hsa-miR-186-5p CFLAR 0.852175445703945 6.88885738584309e-10 -0.60264981549415 0.000146924534874046 mirMAP -0.109533084884528 0.0388776272198057 NA NA NA hsa-miR-320b CFLAR 0.226640952564488 0.378818692487242 -0.60264981549415 0.000146924534874046 miRanda -0.151195453642841 8.91238898066211e-08 NA NA NA hsa-miR-330-5p CFLAR 0.168520831101569 0.336433937906706 -0.60264981549415 0.000146924534874046 miRanda -0.105748491906056 0.0123982677165611 NA NA NA hsa-miR-421 CFLAR 0.170525317701774 0.535277026680289 -0.60264981549415 0.000146924534874046 miRanda -0.108323835564755 0.000185502533497704 NA NA NA hsa-miR-454-3p CFLAR 1.49453641052169 4.46235742871434e-09 -0.60264981549415 0.000146924534874046 mirMAP -0.110766292193923 0.00110247176076177 NA NA NA hsa-miR-708-5p CFLAR 3.04047795672813 3.01085192850869e-20 -0.60264981549415 0.000146924534874046 mirMAP -0.102498067556773 1.52497290863615e-05 NA NA NA hsa-miR-106b-5p CHP2 1.47447672652218 1.32004094930462e-13 -0.698246795377642 0.27546655425478 MirTarget -0.289307563984085 0.046059718658527 NA NA NA hsa-miR-582-5p CHP2 1.08286181406653 0.00149040450161757 -0.698246795377642 0.27546655425478 miRNATAP -0.174545230260245 0.0486087191670937 NA NA NA hsa-miR-15a-5p CHUK 1.62575353599172 1.55312121019827e-19 0.0377297766878195 0.74424413982199 miRNAWalker2_validate;miRTarBase;MirTarget -0.156480048093973 2.55421092282135e-08 NA NA NA hsa-miR-29b-2-5p CHUK 0.345881055247341 0.194842633194187 0.0377297766878195 0.74424413982199 MirTarget -0.119533869512923 1.02102108327589e-09 NA NA NA hsa-miR-339-5p CHUK 0.536997313601114 0.0488090394176611 0.0377297766878195 0.74424413982199 miRanda -0.101676919866514 1.24374098863621e-07 NA NA NA hsa-miR-342-3p CHUK -0.128691966564961 0.561034080130801 0.0377297766878195 0.74424413982199 miRanda -0.176769532720248 4.41422217910121e-14 NA NA NA hsa-miR-497-5p CHUK -0.0546347378264729 0.786205564901684 0.0377297766878195 0.74424413982199 MirTarget -0.194599570543196 4.42801403790986e-14 NA NA NA hsa-miR-15b-3p CSF2RB 0.804736041893915 0.000400279611457186 -1.28440879414381 5.98600010060944e-07 mirMAP -0.146763154921606 0.00821763442889796 NA NA NA hsa-miR-181d-5p CSF2RB 1.19058140522592 8.5908558852417e-09 -1.28440879414381 5.98600010060944e-07 MirTarget -0.225138318949885 7.93227254228292e-05 NA NA NA hsa-miR-19a-3p CSF2RB 2.11776595911517 7.07663078397156e-10 -1.28440879414381 5.98600010060944e-07 MirTarget -0.167733606420829 3.84098493798594e-05 NA NA NA hsa-miR-19b-3p CSF2RB 2.10868505662119 5.40846613768389e-17 -1.28440879414381 5.98600010060944e-07 MirTarget -0.250069990582844 1.95558645843003e-07 NA NA NA hsa-miR-139-5p CYCS -2.26625553116965 7.22375119369519e-16 0.533584069273294 0.000797541450763797 miRanda -0.177347725394177 7.68044998537411e-13 NA NA NA hsa-miR-342-3p CYCS -0.128691966564961 0.561034080130801 0.533584069273294 0.000797541450763797 mirMAP -0.104452481938135 0.00171342515724575 NA NA NA hsa-miR-342-3p DFFA -0.128691966564961 0.561034080130801 0.208253468929684 0.0467186752814201 mirMAP -0.115285301351606 8.73927415674084e-08 NA NA NA hsa-miR-664a-3p DFFA 0.443077463053857 0.0214248925850984 0.208253468929684 0.0467186752814201 mirMAP -0.110989880099499 8.08861826721901e-06 NA NA NA hsa-miR-365a-3p DFFB 0.0132777124336201 0.953597412537431 0.546892122693686 1.60242947893897e-05 MirTarget -0.120376568746021 2.66199233996373e-06 NA NA NA hsa-miR-130a-3p ENDOD1 0.881660100597014 0.000158893668519248 0.0574724229589449 0.802287884473109 MirTarget -0.158689380972218 0.00041229224437697 NA NA NA hsa-miR-130b-3p ENDOD1 1.83046548750752 5.04753914574694e-13 0.0574724229589449 0.802287884473109 MirTarget -0.210698970673308 6.99903178813071e-07 NA NA NA hsa-miR-16-1-3p ENDOD1 1.50034693398929 6.63958242991125e-10 0.0574724229589449 0.802287884473109 mirMAP -0.115978052272091 0.0292641693507515 NA NA NA hsa-miR-181d-5p ENDOD1 1.19058140522592 8.5908558852417e-09 0.0574724229589449 0.802287884473109 MirTarget -0.12246584317684 0.0152429489204304 NA NA NA hsa-miR-193a-3p ENDOD1 0.549173467360291 0.0319030569365466 0.0574724229589449 0.802287884473109 miRanda -0.179134327621172 5.86428802529883e-05 NA NA NA hsa-miR-193b-3p ENDOD1 1.10444771306846 0.000822888533401377 0.0574724229589449 0.802287884473109 miRNAWalker2_validate -0.193643641182539 6.00652244423002e-10 NA NA NA hsa-miR-19a-3p ENDOD1 2.11776595911517 7.07663078397156e-10 0.0574724229589449 0.802287884473109 mirMAP -0.235527854014124 2.65333290963475e-11 NA NA NA hsa-miR-19b-3p ENDOD1 2.10868505662119 5.40846613768389e-17 0.0574724229589449 0.802287884473109 mirMAP -0.214871885885688 3.84099142028988e-07 NA NA NA hsa-miR-20a-3p ENDOD1 2.51803599558247 4.92479325298629e-13 0.0574724229589449 0.802287884473109 MirTarget -0.258852413152086 4.13602159312108e-12 NA NA NA hsa-miR-26b-3p ENDOD1 1.37388760789373 8.32526977075803e-09 0.0574724229589449 0.802287884473109 mirMAP -0.162737534659261 0.000183085338364621 NA NA NA hsa-miR-301a-3p ENDOD1 2.70198002906399 1.56420889710984e-14 0.0574724229589449 0.802287884473109 MirTarget -0.118583472939953 0.00100830851237753 NA NA NA hsa-miR-330-5p ENDOD1 0.168520831101569 0.336433937906706 0.0574724229589449 0.802287884473109 miRanda -0.177326193881245 0.00347844815306811 NA NA NA hsa-miR-335-3p ENDOD1 1.51116383169018 6.88553098788624e-13 0.0574724229589449 0.802287884473109 MirTarget -0.1214967075304 0.0133545590055334 NA NA NA hsa-miR-454-3p ENDOD1 1.49453641052169 4.46235742871434e-09 0.0574724229589449 0.802287884473109 MirTarget -0.200136555991206 3.83646380056291e-05 NA NA NA hsa-miR-590-3p ENDOD1 0.83851360565783 0.00129224433453587 0.0574724229589449 0.802287884473109 miRanda -0.138507749964506 0.00426365654870339 NA NA NA hsa-miR-24-3p EXOG -0.0357874587555003 0.785865078836504 -0.186000325296265 0.0840226962857193 MirTarget -0.104890843185061 0.00597723200942725 NA NA NA hsa-miR-106a-5p FAS 1.3902608059488 6.07931522284525e-05 -0.878746828084236 0.000340153420442741 miRNAWalker2_validate;miRTarBase -0.274948885695996 7.27787651364869e-15 22431000;27142596 miR 106a is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS; Bioinformatic analysis combining with validation experiments identified FAS as a direct target of miR-106a; Moreover a significant inverse correlation was found between miR-106a and FAS expression not only in gastric cancer cell lines but also in gastric cancer specimens; Taken together these findings suggest that ectopicly overexpressed miR-106a may play an oncogenic role in gastric carcinogenesis and impair extrinsic apoptotic pathway through targeting FAS;Functional experiment ascertained that miR-106a interacted with FAS and mediated caspase3 pathway tumorigenesis; gastric cancer;gastric cancer hsa-miR-590-5p FAS 2.07441240363458 4.95240551694843e-14 -0.878746828084236 0.000340153420442741 miRanda -0.282578087201106 9.10535063456113e-09 NA NA NA hsa-let-7e-5p FASLG -0.749418249305995 7.34668338492227e-05 0.227219484524508 0.525243087995098 miRNATAP -0.243056494896728 0.00520293662614488 NA NA NA hsa-miR-107 IKBKG 0.658676029898313 5.11480446318819e-07 0.0843830838323729 0.544710841322622 miRanda -0.126711425730293 0.00969342977912645 NA NA NA hsa-miR-143-3p IKBKG -1.21021691908494 5.70938667332876e-06 0.0843830838323729 0.544710841322622 mirMAP -0.162693115202678 2.58257152475095e-12 NA NA NA hsa-miR-17-3p IKBKG 1.36706429551147 4.60388403547821e-13 0.0843830838323729 0.544710841322622 mirMAP -0.124943383525099 0.000155383572679206 NA NA NA hsa-miR-24-3p IKBKG -0.0357874587555003 0.785865078836504 0.0843830838323729 0.544710841322622 mirMAP -0.14327021053209 0.00372994900140062 NA NA NA hsa-miR-330-3p IKBKG -0.716924999893351 0.000796236278616087 0.0843830838323729 0.544710841322622 mirMAP -0.174026313241355 3.45303704238481e-09 NA NA NA hsa-miR-141-3p IL1A 3.36993755486106 5.42939251147195e-32 -2.78589291846042 1.94445738122673e-09 MirTarget -0.425166348436577 1.11437754257848e-09 NA NA NA hsa-miR-181c-5p IL1A 0.529875814537156 0.0125885822998008 -2.78589291846042 1.94445738122673e-09 MirTarget -0.41989445653036 3.99923207839548e-05 NA NA NA hsa-miR-181d-5p IL1A 1.19058140522592 8.5908558852417e-09 -2.78589291846042 1.94445738122673e-09 MirTarget -0.495373056794971 1.57350244087555e-06 NA NA NA hsa-miR-200a-3p IL1A 3.14766878548496 1.32850889777422e-21 -2.78589291846042 1.94445738122673e-09 MirTarget -0.451074234294195 9.33609082814678e-13 NA NA NA hsa-miR-30b-5p IL1A 0.358144314839612 0.138026229059594 -2.78589291846042 1.94445738122673e-09 MirTarget -0.372796563568777 3.38432266671698e-05 NA NA NA hsa-miR-30d-5p IL1A -0.920901858717441 3.50898334321668e-05 -2.78589291846042 1.94445738122673e-09 MirTarget -0.356697596588321 0.000238401377855495 NA NA NA hsa-miR-30e-5p IL1A 1.60414100786743 3.78951090573667e-19 -2.78589291846042 1.94445738122673e-09 MirTarget -0.387129646844589 0.000947181744027959 NA NA NA hsa-miR-335-5p IL1A -0.466533891325811 0.0676987038122831 -2.78589291846042 1.94445738122673e-09 miRNAWalker2_validate -0.363571202142101 0.000134067450135358 NA NA NA hsa-miR-664a-3p IL1A 0.443077463053857 0.0214248925850984 -2.78589291846042 1.94445738122673e-09 MirTarget -0.399970970989528 0.000411462536175719 NA NA NA hsa-miR-21-5p IL1B 4.38165933891779 1.52536633902505e-92 -1.4197099567083 1.3846626069017e-05 miRNAWalker2_validate;miRTarBase;MirTarget -0.134391564023665 0.0201828525145957 NA NA NA hsa-miR-30d-3p IL1B 0.00396376345349925 0.986457040013182 -1.4197099567083 1.3846626069017e-05 MirTarget -0.185546241965733 0.0112697160369794 NA NA NA hsa-miR-7-1-3p IL1B 2.61364240402652 1.98959237815786e-32 -1.4197099567083 1.3846626069017e-05 MirTarget -0.204885242824381 0.00248885388859552 NA NA NA hsa-miR-130b-5p IL1R1 1.53645187062942 1.10498816261505e-08 -0.902036062273456 1.24728661303111e-05 mirMAP -0.20947298252971 1.38476702999555e-09 NA NA NA hsa-miR-17-3p IL1R1 1.36706429551147 4.60388403547821e-13 -0.902036062273456 1.24728661303111e-05 mirMAP -0.291254110034348 2.75619676884419e-09 NA NA NA hsa-miR-186-5p IL1R1 0.852175445703945 6.88885738584309e-10 -0.902036062273456 1.24728661303111e-05 mirMAP -0.330097048462088 1.4514081890525e-06 NA NA NA hsa-miR-26b-5p IL1R1 0.72362441215247 4.7794659748036e-05 -0.902036062273456 1.24728661303111e-05 mirMAP -0.151138951739801 0.00500687907349492 NA NA NA hsa-miR-335-3p IL1R1 1.51116383169018 6.88553098788624e-13 -0.902036062273456 1.24728661303111e-05 mirMAP -0.292160492099576 2.30254080656226e-11 NA NA NA hsa-miR-361-5p IL1R1 0.21454431962475 0.0800957579368424 -0.902036062273456 1.24728661303111e-05 miRanda -0.202848902425797 0.0110414646766357 NA NA NA hsa-miR-590-3p IL1R1 0.83851360565783 0.00129224433453587 -0.902036062273456 1.24728661303111e-05 miRanda;miRNATAP -0.166712189356744 0.00014487477422078 NA NA NA hsa-miR-139-5p IL1RAP -2.26625553116965 7.22375119369519e-16 0.000245152751386257 0.999187506373076 miRanda -0.118443639544596 0.00188256138463295 NA NA NA hsa-miR-16-1-3p IL1RAP 1.50034693398929 6.63958242991125e-10 0.000245152751386257 0.999187506373076 mirMAP -0.140048006210677 0.0120173981404929 NA NA NA hsa-miR-17-5p IL1RAP 2.07078488653279 2.77403038572568e-19 0.000245152751386257 0.999187506373076 MirTarget;TargetScan -0.201324308672122 1.15234440604181e-05 NA NA NA hsa-miR-186-5p IL1RAP 0.852175445703945 6.88885738584309e-10 0.000245152751386257 0.999187506373076 mirMAP -0.220997757431585 0.00560235433690743 NA NA NA hsa-miR-19a-3p IL1RAP 2.11776595911517 7.07663078397156e-10 0.000245152751386257 0.999187506373076 MirTarget -0.204065274766844 4.68860420392829e-08 NA NA NA hsa-miR-19b-3p IL1RAP 2.10868505662119 5.40846613768389e-17 0.000245152751386257 0.999187506373076 MirTarget -0.227644553615202 2.9123960861649e-07 NA NA NA hsa-miR-204-5p IL1RAP -1.01965803752657 0.00767207541525746 0.000245152751386257 0.999187506373076 miRNAWalker2_validate -0.108955560529284 0.000176986072537337 NA NA NA hsa-miR-20a-5p IL1RAP 2.64649625616975 5.1469418982085e-27 0.000245152751386257 0.999187506373076 MirTarget -0.207167611000991 8.81529955413445e-07 NA NA NA hsa-miR-29a-3p IL1RAP 0.101650412194573 0.573201097011668 0.000245152751386257 0.999187506373076 MirTarget;miRNATAP -0.191769017989552 0.00191288163853844 NA NA NA hsa-miR-29b-3p IL1RAP 3.10527711861309 3.01242507282711e-32 0.000245152751386257 0.999187506373076 MirTarget;miRNATAP -0.204557456978232 1.41972422604361e-07 NA NA NA hsa-miR-29c-3p IL1RAP 1.32354490728858 1.84279305179762e-07 0.000245152751386257 0.999187506373076 MirTarget;miRNATAP -0.168567921542829 8.63855866890971e-05 NA NA NA hsa-miR-375 IL1RAP 0.615547997686534 0.149199273675144 0.000245152751386257 0.999187506373076 miRNAWalker2_validate;miRanda -0.142709680140902 2.39984635102537e-08 NA NA NA hsa-miR-454-3p IL1RAP 1.49453641052169 4.46235742871434e-09 0.000245152751386257 0.999187506373076 MirTarget -0.13278942771255 0.00959574339052586 NA NA NA hsa-miR-576-5p IL1RAP 1.02693643167056 1.14846964470173e-06 0.000245152751386257 0.999187506373076 mirMAP -0.150524986290784 0.00382112305947481 NA NA NA hsa-miR-582-5p IL1RAP 1.08286181406653 0.00149040450161757 0.000245152751386257 0.999187506373076 MirTarget -0.139501140069638 2.33773623468932e-05 NA NA NA hsa-miR-664a-3p IL1RAP 0.443077463053857 0.0214248925850984 0.000245152751386257 0.999187506373076 mirMAP -0.152730147384317 0.00816289760017588 NA NA NA hsa-miR-7-1-3p IL1RAP 2.61364240402652 1.98959237815786e-32 0.000245152751386257 0.999187506373076 MirTarget -0.125460645664714 0.0112093164942368 NA NA NA hsa-miR-93-5p IL1RAP 1.50844106515467 1.83836866996875e-12 0.000245152751386257 0.999187506373076 MirTarget -0.112688886804948 0.0262344005966696 NA NA NA hsa-miR-95-3p IL1RAP -0.191519075333182 0.533735544214583 0.000245152751386257 0.999187506373076 MirTarget -0.132874977071657 0.000340944679739554 NA NA NA hsa-miR-146a-5p IRAK1 0.684701497250824 0.0105316554224149 1.11249641990519 7.42189849563542e-14 miRNAWalker2_validate;miRTarBase -0.101832573808984 0.000147555897647003 25242818;22846912;21632853 Interestingly re-expression of miR-146a inhibited the invasive capacity of Colo357 and Panc-1 PC cells with concomitant down-regulation of EGFR and IRAK-1; Most importantly we found that the treatment of PC cells with "natural agents" 33'-diinodolylmethane DIM or isoflavone led to an increase in the expression of miR-146a and consequently down-regulated the expression of EGFR MTA-2 IRAK-1 and NF-κB resulting in the inhibition of invasion of Colo357 and Panc-1 cells;Functional analysis revealed that miR-146a rs2910164 C allele inhibited cell proliferation and significantly downregulated expression of IRAK1 and TRAF6 in bladder cancer cells;The regulation of EGFR and IRAK1 by miR-146a was examined with miR-146a-transfected gastric cancer cells; Ectopic expression of miR-146a inhibited migration and invasion and downregulated EGFR and IRAK1 expression in gastric cancer cells; MiR-146a targeting of EGFR and IRAK1 is an independent prognostic factor in gastric cancer cases ;; pancreatic cancer;bladder cancer;gastric cancer hsa-miR-335-5p IRAK2 -0.466533891325811 0.0676987038122831 0.567287186290348 0.0152967123507346 miRNAWalker2_validate -0.16550007553947 0.00045872865745022 NA NA NA hsa-miR-141-3p IRAK3 3.36993755486106 5.42939251147195e-32 -1.31653047867367 9.84276567820939e-06 mirMAP -0.146294779355006 0.00115134062341314 NA NA NA hsa-miR-20a-3p IRAK3 2.51803599558247 4.92479325298629e-13 -1.31653047867367 9.84276567820939e-06 mirMAP -0.187141915295028 0.000174865553791266 NA NA NA hsa-miR-21-5p IRAK3 4.38165933891779 1.52536633902505e-92 -1.31653047867367 9.84276567820939e-06 mirMAP -0.201892704895579 0.000120101491819665 NA NA NA hsa-miR-25-3p IRAK3 0.361927330834176 0.0163670566170988 -1.31653047867367 9.84276567820939e-06 mirMAP -0.239604432744736 0.00982482842095353 NA NA NA hsa-miR-3200-3p IRAK3 0.521712783553188 0.134990592651885 -1.31653047867367 9.84276567820939e-06 mirMAP -0.147424016420393 0.000299400692988312 NA NA NA hsa-miR-324-5p IRAK3 1.06955541886548 5.39722006604758e-05 -1.31653047867367 9.84276567820939e-06 miRanda -0.138862111225755 0.00751997615275624 NA NA NA hsa-miR-335-3p IRAK3 1.51116383169018 6.88553098788624e-13 -1.31653047867367 9.84276567820939e-06 mirMAP -0.447288987971565 1.16142984363208e-12 NA NA NA hsa-miR-33a-5p IRAK3 2.80127809675219 5.09053890529424e-12 -1.31653047867367 9.84276567820939e-06 mirMAP -0.129087503700998 0.00174107996862328 NA NA NA hsa-miR-421 IRAK3 0.170525317701774 0.535277026680289 -1.31653047867367 9.84276567820939e-06 miRanda;mirMAP -0.132796225968858 0.0154793959682764 NA NA NA hsa-miR-450b-5p IRAK3 1.69248953402469 1.96052058003353e-07 -1.31653047867367 9.84276567820939e-06 mirMAP -0.176423483699516 0.000163748438267334 NA NA NA hsa-miR-501-5p IRAK3 0.411357595674671 0.10435288464149 -1.31653047867367 9.84276567820939e-06 mirMAP -0.115229192234932 0.0356103577466442 NA NA NA hsa-miR-589-3p IRAK3 1.34253876396688 1.84935927493927e-05 -1.31653047867367 9.84276567820939e-06 mirMAP -0.129315117987875 0.00422615870683415 NA NA NA hsa-miR-590-5p IRAK3 2.07441240363458 4.95240551694843e-14 -1.31653047867367 9.84276567820939e-06 mirMAP -0.230007167814281 0.000144934857159697 NA NA NA hsa-miR-660-5p IRAK3 2.04875198906126 1.08269480928897e-17 -1.31653047867367 9.84276567820939e-06 mirMAP -0.132393087948539 0.0211062757131547 NA NA NA hsa-miR-106b-5p MAP3K14 1.47447672652218 1.32004094930462e-13 -0.508395608018966 0.005388667824716 MirTarget -0.148081791172922 0.000331285249363202 NA NA NA hsa-miR-17-3p MAP3K14 1.36706429551147 4.60388403547821e-13 -0.508395608018966 0.005388667824716 MirTarget -0.160398561527579 0.000231985049439229 NA NA NA hsa-miR-365a-3p MYD88 0.0132777124336201 0.953597412537431 -0.587709074735129 7.43383821392277e-07 MirTarget -0.123020139940839 3.03625517446058e-07 NA NA NA hsa-miR-429 MYD88 2.3794516574089 1.72813419703734e-13 -0.587709074735129 7.43383821392277e-07 miRanda -0.113048835976415 1.68777256167566e-10 NA NA NA hsa-miR-671-5p NFKB1 2.24156654191798 2.10433241567652e-14 -0.340270335589995 0.00609383891055805 MirTarget -0.104865468815509 3.02257267140541e-06 NA NA NA hsa-let-7b-5p NGF -1.62016148171663 1.56547487335694e-15 0.201813000750518 0.680403675107959 MirTarget -0.242858337482323 0.0246273998823271 NA NA NA hsa-miR-320a NGF -0.961144925954715 1.62478794429204e-08 0.201813000750518 0.680403675107959 miRanda -0.306575920656902 0.0199126531419783 NA NA NA hsa-miR-320b NGF 0.226640952564488 0.378818692487242 0.201813000750518 0.680403675107959 miRanda -0.175428791274416 0.0460777091944554 NA NA NA hsa-miR-185-3p NTRK1 -0.377490365509078 0.093653288903368 -1.20191019732804 0.000181518709629851 MirTarget -0.220344116634979 0.000867618792014595 NA NA NA hsa-miR-186-5p PIK3CA 0.852175445703945 6.88885738584309e-10 -0.335143841150832 0.0107695904000801 mirMAP -0.158211833933772 0.000271764939125213 NA NA NA hsa-miR-501-5p PIK3CA 0.411357595674671 0.10435288464149 -0.335143841150832 0.0107695904000801 mirMAP -0.12161859871495 2.80222388365699e-07 NA NA NA hsa-miR-96-5p PIK3CA 3.0381097138467 4.40362891630201e-24 -0.335143841150832 0.0107695904000801 TargetScan -0.126074442438012 7.26672594996813e-09 NA NA NA hsa-miR-454-3p PIK3CB 1.49453641052169 4.46235742871434e-09 0.0520424688078016 0.708498300848208 miRNATAP -0.107092855274913 0.000279808925292599 NA NA NA hsa-miR-421 PIK3CD 0.170525317701774 0.535277026680289 -0.165252183051274 0.400815192488832 miRanda -0.187035284767016 1.2803934448503e-07 NA NA NA hsa-miR-148b-3p PIK3CG 0.483970528590224 0.0026495409465901 -1.19325793461087 5.28114748039233e-05 miRNAWalker2_validate -0.239430332797948 0.00515332606189168 NA NA NA hsa-miR-26b-5p PIK3CG 0.72362441215247 4.7794659748036e-05 -1.19325793461087 5.28114748039233e-05 miRNAWalker2_validate -0.285401672500096 0.000198071700272844 NA NA NA hsa-miR-29b-3p PIK3CG 3.10527711861309 3.01242507282711e-32 -1.19325793461087 5.28114748039233e-05 miRTarBase -0.13454994451672 0.00563635188925694 NA NA NA hsa-miR-335-3p PIK3CG 1.51116383169018 6.88553098788624e-13 -1.19325793461087 5.28114748039233e-05 mirMAP -0.273824058387904 1.51960031354635e-05 NA NA NA hsa-miR-542-3p PIK3CG 1.62226640768239 2.6427102465476e-10 -1.19325793461087 5.28114748039233e-05 miRanda -0.188110029792226 0.000315799878113487 NA NA NA hsa-miR-106a-5p PIK3R1 1.3902608059488 6.07931522284525e-05 -1.28526113405546 1.1596112892202e-14 MirTarget;miRNATAP -0.152594260668069 8.26964346589391e-10 NA NA NA hsa-miR-106b-5p PIK3R1 1.47447672652218 1.32004094930462e-13 -1.28526113405546 1.1596112892202e-14 MirTarget;miRNATAP -0.274486784039244 3.92361901886501e-13 NA NA NA hsa-miR-107 PIK3R1 0.658676029898313 5.11480446318819e-07 -1.28526113405546 1.1596112892202e-14 MirTarget;PITA;miRanda;miRNATAP -0.134608742116129 0.0261488734968106 NA NA NA hsa-miR-128-3p PIK3R1 1.03509868349735 2.11606310588315e-10 -1.28526113405546 1.1596112892202e-14 MirTarget -0.262733562571172 2.81828198129055e-08 25962360 miR 128 3p suppresses hepatocellular carcinoma proliferation by regulating PIK3R1 and is correlated with the prognosis of HCC patients; Mechanistically miR-128-3p was confirmed to regulate PIK3R1 p85α expression thereby suppressing phosphatidylinositol 3-kinase PI3K/AKT pathway activation using qRT-PCR and western blot analysis; Hence we conclude that miR-128-3p which is frequently downregulated in HCC inhibits HCC progression by regulating PIK3R1 and PI3K/AKT activation and is a prognostic marker for HCC patients worse prognosis;progression liver cancer hsa-miR-1301-3p PIK3R1 0.845987603184611 0.000579808501723616 -1.28526113405546 1.1596112892202e-14 MirTarget -0.252566507630763 3.89638206850943e-16 NA NA NA hsa-miR-15a-5p PIK3R1 1.62575353599172 1.55312121019827e-19 -1.28526113405546 1.1596112892202e-14 MirTarget -0.198845640675418 2.2459439580454e-06 NA NA NA hsa-miR-16-2-3p PIK3R1 0.503964803530872 0.0263648405197492 -1.28526113405546 1.1596112892202e-14 MirTarget -0.215346374588015 7.85659740371802e-09 NA NA NA hsa-miR-16-5p PIK3R1 0.749619098384047 4.11649450706988e-06 -1.28526113405546 1.1596112892202e-14 MirTarget -0.14663084031301 0.00245632583144358 NA NA NA hsa-miR-17-5p PIK3R1 2.07078488653279 2.77403038572568e-19 -1.28526113405546 1.1596112892202e-14 MirTarget;TargetScan;miRNATAP -0.30827377198364 1.00416866782136e-22 NA NA NA hsa-miR-182-5p PIK3R1 3.21839823004635 5.13049145201115e-39 -1.28526113405546 1.1596112892202e-14 miRNATAP -0.153577568348738 1.31399000956901e-07 NA NA NA hsa-miR-185-5p PIK3R1 1.14291034858482 2.95777119743491e-13 -1.28526113405546 1.1596112892202e-14 miRNATAP -0.266123472564886 5.49627003455298e-08 NA NA NA hsa-miR-186-5p PIK3R1 0.852175445703945 6.88885738584309e-10 -1.28526113405546 1.1596112892202e-14 mirMAP -0.266496146428416 2.3226235073163e-06 NA NA NA hsa-miR-200c-3p PIK3R1 0.380533388300368 0.0842181838538353 -1.28526113405546 1.1596112892202e-14 mirMAP -0.174738637328334 9.22364461849854e-07 NA NA NA hsa-miR-20a-5p PIK3R1 2.64649625616975 5.1469418982085e-27 -1.28526113405546 1.1596112892202e-14 MirTarget;miRNATAP -0.268255645046992 2.93530513676098e-20 NA NA NA hsa-miR-21-5p PIK3R1 4.38165933891779 1.52536633902505e-92 -1.28526113405546 1.1596112892202e-14 miRNAWalker2_validate;MirTarget;miRNATAP -0.239855941401679 1.66617444081141e-16 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-22-5p PIK3R1 1.71436244278242 9.85038001236064e-15 -1.28526113405546 1.1596112892202e-14 mirMAP -0.249170402831725 1.77307790115702e-13 NA NA NA hsa-miR-29b-3p PIK3R1 3.10527711861309 3.01242507282711e-32 -1.28526113405546 1.1596112892202e-14 MirTarget;miRNATAP -0.169264704761152 8.1620915503371e-10 NA NA NA hsa-miR-335-3p PIK3R1 1.51116383169018 6.88553098788624e-13 -1.28526113405546 1.1596112892202e-14 mirMAP -0.174731000503181 1.56931158200611e-06 NA NA NA hsa-miR-424-5p PIK3R1 1.26485330287919 6.1498991028257e-06 -1.28526113405546 1.1596112892202e-14 MirTarget -0.120660860108298 1.41199550729587e-05 NA NA NA hsa-miR-450b-5p PIK3R1 1.69248953402469 1.96052058003353e-07 -1.28526113405546 1.1596112892202e-14 miRNATAP -0.105483872062601 7.60035078150308e-05 NA NA NA hsa-miR-582-5p PIK3R1 1.08286181406653 0.00149040450161757 -1.28526113405546 1.1596112892202e-14 mirMAP -0.121659359408152 1.98808465862233e-07 NA NA NA hsa-miR-589-3p PIK3R1 1.34253876396688 1.84935927493927e-05 -1.28526113405546 1.1596112892202e-14 mirMAP -0.110115880585781 1.73041185531321e-05 NA NA NA hsa-miR-590-3p PIK3R1 0.83851360565783 0.00129224433453587 -1.28526113405546 1.1596112892202e-14 miRanda;mirMAP -0.21433969556349 1.93094554722457e-09 NA NA NA hsa-miR-590-5p PIK3R1 2.07441240363458 4.95240551694843e-14 -1.28526113405546 1.1596112892202e-14 MirTarget;PITA;miRanda;miRNATAP -0.297606057222883 4.39734655384069e-19 NA NA NA hsa-miR-629-3p PIK3R1 1.31892116211001 0.000114487182853678 -1.28526113405546 1.1596112892202e-14 MirTarget -0.155200085033098 2.2200629415611e-10 NA NA NA hsa-miR-93-5p PIK3R1 1.50844106515467 1.83836866996875e-12 -1.28526113405546 1.1596112892202e-14 MirTarget;miRNATAP -0.302548872464343 3.62432128460294e-18 NA NA NA hsa-miR-96-5p PIK3R1 3.0381097138467 4.40362891630201e-24 -1.28526113405546 1.1596112892202e-14 TargetScan;miRNATAP -0.247820034174453 4.28366535969023e-19 NA NA NA hsa-miR-29b-1-5p PIK3R3 1.71024742617744 3.64915691793611e-09 -0.993075734580867 1.37876508579496e-06 mirMAP -0.137607471527013 2.02669327816331e-05 NA NA NA hsa-miR-335-3p PIK3R3 1.51116383169018 6.88553098788624e-13 -0.993075734580867 1.37876508579496e-06 mirMAP -0.239450639911665 5.21180596069304e-08 NA NA NA hsa-miR-107 PIK3R5 0.658676029898313 5.11480446318819e-07 -1.41857329052665 4.9150449517908e-09 miRanda -0.303365993068523 0.000471196296141979 NA NA NA hsa-miR-182-5p PIK3R5 3.21839823004635 5.13049145201115e-39 -1.41857329052665 4.9150449517908e-09 MirTarget -0.327566926397612 1.58877421029473e-15 NA NA NA hsa-miR-106a-5p PPP3CA 1.3902608059488 6.07931522284525e-05 -0.313973239016408 0.0165177462343014 miRNATAP -0.133933104567234 1.19345709173472e-12 NA NA NA hsa-miR-142-3p PPP3CA 3.98476449801341 1.56256182021111e-35 -0.313973239016408 0.0165177462343014 miRNATAP -0.118826172048727 2.75854825586705e-12 NA NA NA hsa-miR-17-5p PPP3CA 2.07078488653279 2.77403038572568e-19 -0.313973239016408 0.0165177462343014 miRNATAP -0.176015588845375 7.62312188608765e-13 NA NA NA hsa-miR-186-5p PPP3CA 0.852175445703945 6.88885738584309e-10 -0.313973239016408 0.0165177462343014 mirMAP -0.286847992743368 1.57472937315132e-11 NA NA NA hsa-miR-20a-5p PPP3CA 2.64649625616975 5.1469418982085e-27 -0.313973239016408 0.0165177462343014 miRNATAP -0.154552998486965 9.11892644521842e-12 NA NA NA hsa-miR-20b-5p PPP3CA 1.35770573270947 0.00260808530013016 -0.313973239016408 0.0165177462343014 miRNATAP -0.122294666346707 1.15249428256532e-19 NA NA NA hsa-miR-30c-5p PPP3CA -0.327319105755825 0.123595832152687 -0.313973239016408 0.0165177462343014 miRNATAP -0.10873673306536 0.000125286600086868 NA NA NA hsa-miR-361-3p PPP3CA 0.0988926195529967 0.549128728500555 -0.313973239016408 0.0165177462343014 MirTarget;PITA;miRNATAP -0.173641727258806 2.07130127414673e-06 NA NA NA hsa-miR-501-3p PPP3CA -0.0405952693028064 0.866802243505833 -0.313973239016408 0.0165177462343014 MirTarget;PITA;miRNATAP -0.152231773192009 5.82453493976863e-10 NA NA NA hsa-miR-502-3p PPP3CA -0.262270070977708 0.161760375279961 -0.313973239016408 0.0165177462343014 MirTarget;PITA;miRNATAP -0.102225645893012 0.00155670003675052 NA NA NA hsa-miR-589-3p PPP3CA 1.34253876396688 1.84935927493927e-05 -0.313973239016408 0.0165177462343014 MirTarget -0.111512777165905 9.25189699847489e-09 NA NA NA hsa-miR-590-3p PPP3CA 0.83851360565783 0.00129224433453587 -0.313973239016408 0.0165177462343014 miRanda;mirMAP -0.108711400054004 7.97592745451833e-05 NA NA NA hsa-miR-590-5p PPP3CA 2.07441240363458 4.95240551694843e-14 -0.313973239016408 0.0165177462343014 PITA;miRanda;miRNATAP -0.177690930412641 6.75602594094779e-12 NA NA NA hsa-miR-7-1-3p PPP3CA 2.61364240402652 1.98959237815786e-32 -0.313973239016408 0.0165177462343014 MirTarget;mirMAP -0.121059394653456 5.88147588879243e-06 NA NA NA hsa-miR-93-3p PPP3CA 1.07631808403007 1.63747525692813e-05 -0.313973239016408 0.0165177462343014 miRNATAP -0.170128744194282 3.50156314525736e-13 NA NA NA hsa-miR-93-5p PPP3CA 1.50844106515467 1.83836866996875e-12 -0.313973239016408 0.0165177462343014 miRNATAP -0.25180151434334 1.28858993768457e-21 NA NA NA hsa-miR-15a-5p PPP3CB 1.62575353599172 1.55312121019827e-19 -0.217161149975175 0.026537796620393 miRNATAP -0.123109224513088 2.45320870406106e-07 NA NA NA hsa-miR-30c-5p PPP3CB -0.327319105755825 0.123595832152687 -0.217161149975175 0.026537796620393 miRNATAP -0.117562918064524 1.93721091880072e-08 NA NA NA hsa-miR-361-5p PPP3CB 0.21454431962475 0.0800957579368424 -0.217161149975175 0.026537796620393 miRanda -0.127974103120468 0.000592380004256261 NA NA NA hsa-miR-361-5p PPP3CC 0.21454431962475 0.0800957579368424 -0.864879436917075 5.11810186256782e-12 miRanda -0.162282770575647 0.000912467378574366 NA NA NA hsa-miR-181a-5p PPP3R1 -0.375429731222937 0.0562142867129802 -0.021451907795778 0.828812244123992 MirTarget;miRNATAP -0.174665544764319 9.40491398689482e-15 NA NA NA hsa-miR-181b-5p PPP3R1 0.668793269169928 0.000239998092406404 -0.021451907795778 0.828812244123992 MirTarget;miRNATAP -0.114349020464675 3.84750784901666e-06 NA NA NA hsa-miR-181c-5p PPP3R1 0.529875814537156 0.0125885822998008 -0.021451907795778 0.828812244123992 MirTarget;miRNATAP -0.106737924157465 4.8061231789594e-07 NA NA NA hsa-miR-27b-3p PPP3R1 0.236438984240408 0.12263510345883 -0.021451907795778 0.828812244123992 miRNATAP -0.122284709618602 4.10399666262129e-05 NA NA NA hsa-miR-30b-5p PPP3R1 0.358144314839612 0.138026229059594 -0.021451907795778 0.828812244123992 MirTarget -0.109418887183495 3.74739901258502e-09 NA NA NA hsa-miR-30c-5p PPP3R1 -0.327319105755825 0.123595832152687 -0.021451907795778 0.828812244123992 MirTarget;miRNATAP -0.157231202749467 5.03548982239333e-14 NA NA NA hsa-miR-342-3p PPP3R1 -0.128691966564961 0.561034080130801 -0.021451907795778 0.828812244123992 MirTarget;miRanda;miRNATAP -0.120856614371424 2.53668736670026e-09 NA NA NA hsa-miR-34a-5p PPP3R1 1.40588612517769 8.60097477768592e-12 -0.021451907795778 0.828812244123992 miRNAWalker2_validate -0.170360603226023 4.36468130338985e-16 NA NA NA hsa-let-7a-3p PRKACB 0.167285443861993 0.431834813181487 -0.337490057919314 0.0956151593593903 MirTarget;mirMAP;miRNATAP -0.109621340434496 0.0264314696722877 NA NA NA hsa-miR-141-3p PRKACB 3.36993755486106 5.42939251147195e-32 -0.337490057919314 0.0956151593593903 MirTarget;TargetScan;miRNATAP -0.127873218774198 2.27329955972899e-05 NA NA NA hsa-miR-146b-5p PRKACB 1.0922867893808 5.63754607494775e-06 -0.337490057919314 0.0956151593593903 miRanda -0.16173584971976 2.34820463010476e-05 NA NA NA hsa-miR-16-2-3p PRKACB 0.503964803530872 0.0263648405197492 -0.337490057919314 0.0956151593593903 mirMAP -0.126437256197819 0.00465216057285952 NA NA NA hsa-miR-17-5p PRKACB 2.07078488653279 2.77403038572568e-19 -0.337490057919314 0.0956151593593903 TargetScan -0.146235921583623 0.000160820334409303 NA NA NA hsa-miR-182-5p PRKACB 3.21839823004635 5.13049145201115e-39 -0.337490057919314 0.0956151593593903 MirTarget;miRNATAP -0.112248448456467 0.00121734908239389 NA NA NA hsa-miR-183-5p PRKACB 2.39247234736657 3.92444525331999e-21 -0.337490057919314 0.0956151593593903 MirTarget -0.10185724563834 0.0037757174706069 NA NA NA hsa-miR-19a-3p PRKACB 2.11776595911517 7.07663078397156e-10 -0.337490057919314 0.0956151593593903 MirTarget;miRNATAP -0.170735517959884 5.74076627300856e-08 NA NA NA hsa-miR-19b-3p PRKACB 2.10868505662119 5.40846613768389e-17 -0.337490057919314 0.0956151593593903 miRNAWalker2_validate;MirTarget;miRNATAP -0.197277470144974 1.27039043015725e-07 NA NA NA hsa-miR-200b-3p PRKACB 1.55157578247391 4.83790020897188e-09 -0.337490057919314 0.0956151593593903 MirTarget;TargetScan -0.101454883897731 0.00336247964553013 NA NA NA hsa-miR-200c-3p PRKACB 0.380533388300368 0.0842181838538353 -0.337490057919314 0.0956151593593903 MirTarget;miRNATAP -0.115374415768757 0.00655504187350906 NA NA NA hsa-miR-339-5p PRKACB 0.536997313601114 0.0488090394176611 -0.337490057919314 0.0956151593593903 miRanda -0.172209477372762 3.7061891291678e-07 NA NA NA hsa-miR-34a-5p PRKACB 1.40588612517769 8.60097477768592e-12 -0.337490057919314 0.0956151593593903 miRNATAP -0.249544715069385 1.25392359331725e-08 NA NA NA hsa-miR-362-5p PRKACB 0.658947634569393 0.0243306847205756 -0.337490057919314 0.0956151593593903 PITA -0.152310553896922 2.5944554975563e-06 NA NA NA hsa-miR-429 PRKACB 2.3794516574089 1.72813419703734e-13 -0.337490057919314 0.0956151593593903 MirTarget;PITA;miRanda;miRNATAP -0.120289214888389 7.31299726157361e-05 NA NA NA hsa-miR-590-5p PRKACB 2.07441240363458 4.95240551694843e-14 -0.337490057919314 0.0956151593593903 miRanda -0.106057390676399 0.00956598336443456 NA NA NA hsa-miR-93-5p PRKACB 1.50844106515467 1.83836866996875e-12 -0.337490057919314 0.0956151593593903 miRNAWalker2_validate -0.173603248772151 4.27230598908178e-05 NA NA NA hsa-miR-96-5p PRKACB 3.0381097138467 4.40362891630201e-24 -0.337490057919314 0.0956151593593903 miRNATAP -0.19117539499709 1.28710220181067e-08 NA NA NA hsa-miR-155-5p PRKAR1A 0.813513839059142 0.000608282725633232 -0.476850604449272 2.68687886515723e-05 miRNAWalker2_validate -0.139999488103335 1.05258302094743e-10 NA NA NA hsa-miR-186-5p PRKAR1A 0.852175445703945 6.88885738584309e-10 -0.476850604449272 2.68687886515723e-05 mirMAP -0.187471435255471 5.73112383343186e-07 NA NA NA hsa-miR-25-3p PRKAR1A 0.361927330834176 0.0163670566170988 -0.476850604449272 2.68687886515723e-05 miRNAWalker2_validate -0.132918419142272 0.000149714233560858 NA NA NA hsa-miR-30c-5p PRKAR1A -0.327319105755825 0.123595832152687 -0.476850604449272 2.68687886515723e-05 mirMAP -0.110647555772676 7.09317835691076e-06 NA NA NA hsa-miR-30e-5p PRKAR1A 1.60414100786743 3.78951090573667e-19 -0.476850604449272 2.68687886515723e-05 mirMAP -0.102557156521551 0.000277416995755017 NA NA NA hsa-miR-342-3p PRKAR1A -0.128691966564961 0.561034080130801 -0.476850604449272 2.68687886515723e-05 miRanda -0.195587101672966 2.00849194011625e-17 NA NA NA hsa-miR-590-3p PRKAR1A 0.83851360565783 0.00129224433453587 -0.476850604449272 2.68687886515723e-05 miRanda;mirMAP -0.137053164571483 8.41662596940527e-09 NA NA NA hsa-miR-590-5p PRKAR1A 2.07441240363458 4.95240551694843e-14 -0.476850604449272 2.68687886515723e-05 miRanda -0.195670821518842 1.25064405614133e-18 NA NA NA hsa-miR-96-5p PRKAR1A 3.0381097138467 4.40362891630201e-24 -0.476850604449272 2.68687886515723e-05 miRNAWalker2_validate;TargetScan;miRNATAP -0.128985822937838 6.61017716853541e-12 NA NA NA hsa-let-7a-3p PRKAR2A 0.167285443861993 0.431834813181487 -0.542111912815549 0.00820991566022701 mirMAP -0.129600545591328 0.00965385633423682 NA NA NA hsa-miR-103a-3p PRKAR2A 0.538497806383155 1.88134691850591e-05 -0.542111912815549 0.00820991566022701 miRNAWalker2_validate -0.182915804223543 0.0161204820560304 NA NA NA hsa-miR-106a-5p PRKAR2A 1.3902608059488 6.07931522284525e-05 -0.542111912815549 0.00820991566022701 mirMAP -0.182529692623676 9.11118517871937e-10 NA NA NA hsa-miR-106b-5p PRKAR2A 1.47447672652218 1.32004094930462e-13 -0.542111912815549 0.00820991566022701 mirMAP -0.130098878664838 0.00508433606379257 NA NA NA hsa-miR-10a-3p PRKAR2A 0.162369964979749 0.621747296513628 -0.542111912815549 0.00820991566022701 mirMAP -0.147560768203991 3.61634378140385e-05 NA NA NA hsa-miR-125a-5p PRKAR2A -1.04824536696301 3.97386082850476e-07 -0.542111912815549 0.00820991566022701 miRanda -0.119074803105274 0.00875043226956617 NA NA NA hsa-miR-142-5p PRKAR2A 1.29672439149353 4.0768822158894e-06 -0.542111912815549 0.00820991566022701 mirMAP -0.121135593752335 0.00078655285231452 NA NA NA hsa-miR-148a-3p PRKAR2A 2.30885799126944 1.95226081368985e-21 -0.542111912815549 0.00820991566022701 mirMAP -0.10473104721013 0.00495918694210131 NA NA NA hsa-miR-155-5p PRKAR2A 0.813513839059142 0.000608282725633232 -0.542111912815549 0.00820991566022701 miRNAWalker2_validate -0.146428684740871 0.000220862251552694 NA NA NA hsa-miR-16-5p PRKAR2A 0.749619098384047 4.11649450706988e-06 -0.542111912815549 0.00820991566022701 miRNAWalker2_validate -0.16233712492249 0.0052000527267614 NA NA NA hsa-miR-17-5p PRKAR2A 2.07078488653279 2.77403038572568e-19 -0.542111912815549 0.00820991566022701 mirMAP -0.158416749162573 5.53315845810464e-05 NA NA NA hsa-miR-20a-5p PRKAR2A 2.64649625616975 5.1469418982085e-27 -0.542111912815549 0.00820991566022701 mirMAP -0.177689732696527 8.05056914879578e-07 NA NA NA hsa-miR-21-5p PRKAR2A 4.38165933891779 1.52536633902505e-92 -0.542111912815549 0.00820991566022701 mirMAP -0.150363567953701 2.70425744412111e-05 NA NA NA hsa-miR-26b-5p PRKAR2A 0.72362441215247 4.7794659748036e-05 -0.542111912815549 0.00820991566022701 mirMAP -0.254835302085191 1.33543677793609e-06 NA NA NA hsa-miR-29a-5p PRKAR2A 1.89519956688438 1.03453349363915e-11 -0.542111912815549 0.00820991566022701 mirMAP -0.144340188354051 0.000269848610546557 NA NA NA hsa-miR-32-5p PRKAR2A 0.876853679269853 6.04859399018691e-05 -0.542111912815549 0.00820991566022701 mirMAP -0.149276001882109 0.00141193110732772 NA NA NA hsa-miR-582-5p PRKAR2A 1.08286181406653 0.00149040450161757 -0.542111912815549 0.00820991566022701 miRNATAP -0.106418125415066 0.000164630904331123 NA NA NA hsa-miR-590-5p PRKAR2A 2.07441240363458 4.95240551694843e-14 -0.542111912815549 0.00820991566022701 mirMAP -0.169616630819392 4.04701086495302e-05 NA NA NA hsa-miR-708-3p PRKAR2A 3.43841959417743 4.40027692981683e-28 -0.542111912815549 0.00820991566022701 mirMAP -0.130264413500301 3.805520704434e-05 NA NA NA hsa-miR-186-5p PRKAR2B 0.852175445703945 6.88885738584309e-10 -0.603510949504182 0.0393539020155484 mirMAP -0.203735577280849 0.0366327794799357 NA NA NA hsa-miR-361-5p PRKAR2B 0.21454431962475 0.0800957579368424 -0.603510949504182 0.0393539020155484 miRanda -0.33231834049798 0.00308352468710608 NA NA NA hsa-miR-92a-3p PRKAR2B -0.136362762339122 0.493412263619364 -0.603510949504182 0.0393539020155484 miRNATAP -0.152470358659526 0.0256836387516207 NA NA NA hsa-miR-450b-5p PRKX 1.69248953402469 1.96052058003353e-07 -0.138434262119447 0.395012462656297 mirMAP -0.119346741491602 2.11739235739311e-06 NA NA NA hsa-miR-542-3p PRKX 1.62226640768239 2.6427102465476e-10 -0.138434262119447 0.395012462656297 mirMAP -0.149271020180693 1.30948834311169e-07 NA NA NA hsa-miR-107 TNF 0.658676029898313 5.11480446318819e-07 -0.830982767486341 0.0138827131679617 miRanda -0.439603202171767 0.000221374639268502 NA NA NA hsa-miR-203a-3p TNF 1.06866854356847 0.00389979689199624 -0.830982767486341 0.0138827131679617 miRTarBase -0.103500315237721 0.0136268268780759 NA NA NA hsa-miR-320b TNF 0.226640952564488 0.378818692487242 -0.830982767486341 0.0138827131679617 miRanda -0.148152717399537 0.0147197238778624 NA NA NA hsa-miR-429 TNF 2.3794516574089 1.72813419703734e-13 -0.830982767486341 0.0138827131679617 miRNATAP -0.135544464882007 0.00782170177882693 NA NA NA hsa-miR-362-3p TNFRSF10A 0.194097672030785 0.52808475179225 0.313937445636065 0.126469321676362 miRanda -0.171482203608969 7.28861591280272e-06 NA NA NA hsa-miR-940 TNFRSF10B 0.011138136211269 0.974925352379525 0.178447201136893 0.311593856462823 miRNAWalker2_validate -0.141318772516878 2.62411186947218e-08 NA NA NA hsa-miR-193a-3p TNFRSF10C 0.549173467360291 0.0319030569365466 -0.154947494831521 0.59571603471051 miRanda -0.290120931664436 2.74949804872591e-07 NA NA NA hsa-miR-361-5p TNFRSF10C 0.21454431962475 0.0800957579368424 -0.154947494831521 0.59571603471051 miRanda -0.237444664053092 0.0339776756633854 NA NA NA hsa-miR-362-3p TNFRSF10D 0.194097672030785 0.52808475179225 -1.03846175939343 8.86767948326941e-06 miRanda -0.100403304163926 0.0233388202604092 NA NA NA hsa-miR-590-3p TNFRSF10D 0.83851360565783 0.00129224433453587 -1.03846175939343 8.86767948326941e-06 miRanda -0.116986382261948 0.0191591361661586 NA NA NA hsa-miR-590-5p TNFRSF10D 2.07441240363458 4.95240551694843e-14 -1.03846175939343 8.86767948326941e-06 miRanda -0.154057594157847 0.00120741838184007 NA NA NA hsa-miR-7-1-3p TNFRSF10D 2.61364240402652 1.98959237815786e-32 -1.03846175939343 8.86767948326941e-06 mirMAP -0.136420129073792 0.00490554426295682 NA NA NA hsa-miR-140-3p TRAF2 -1.11373309124537 8.35257079443689e-14 1.00807946070122 6.3314135046518e-09 MirTarget -0.244688143587184 4.1120893831993e-06 NA NA NA hsa-miR-140-3p XIAP -1.11373309124537 8.35257079443689e-14 0.311178443599883 0.00189888955771199 mirMAP -0.134806533023976 7.86246400028474e-06 NA NA NA hsa-miR-17-5p XIAP 2.07078488653279 2.77403038572568e-19 0.311178443599883 0.00189888955771199 miRNAWalker2_validate;TargetScan -0.104621962395686 3.56642452518644e-08 NA NA NA hsa-miR-186-5p XIAP 0.852175445703945 6.88885738584309e-10 0.311178443599883 0.00189888955771199 MirTarget;miRNATAP -0.106770220904771 0.00127610812666367 NA NA NA hsa-miR-25-3p XIAP 0.361927330834176 0.0163670566170988 0.311178443599883 0.00189888955771199 mirMAP -0.105648114201262 0.000601509319956213 NA NA NA hsa-miR-484 XIAP -0.228576985124486 0.244112867390855 0.311178443599883 0.00189888955771199 mirMAP -0.110023475185489 2.657115273949e-06 NA NA NA hsa-miR-92a-3p XIAP -0.136362762339122 0.493412263619364 0.311178443599883 0.00189888955771199 mirMAP -0.115780408737922 5.14759041621164e-07 NA NA NA