miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7a-3p APC 0.180588894055192 0.807497649839616 -0.160220522876079 0.822434015414819 mirMAP -0.246321962648312 7.77199400790286e-10 NA NA NA hsa-let-7b-3p APC 0.273132474559554 0.682533246372485 -0.160220522876079 0.822434015414819 mirMAP -0.304757665718695 2.34015485714337e-08 NA NA NA hsa-let-7f-1-3p APC 1.02975898416111 0.00216616040865014 -0.160220522876079 0.822434015414819 mirMAP -0.250696579315713 1.21851863947436e-09 NA NA NA hsa-miR-106b-5p APC 0.947523403196215 0.405863421831729 -0.160220522876079 0.822434015414819 miRNAWalker2_validate;miRTarBase -0.30242697688908 1.86567518860369e-15 23087084 miR 106b downregulates adenomatous polyposis coli and promotes cell proliferation in human hepatocellular carcinoma; Moreover we demonstrated that miR-106b downregulates APC expression by directly targeting the 3'-untranslated region of APC messenger RNA; Taken together our results suggest that miR-106b plays an important role in promoting the proliferation of human hepatoma cells and presents a novel mechanism of micro RNA-mediated direct suppression of APC expression in cancer cells liver cancer hsa-miR-107 APC 0.808649908398562 0.357609254490153 -0.160220522876079 0.822434015414819 miRanda -0.227554281523103 0.00011321242972963 NA NA NA hsa-miR-125a-5p APC -0.134418454752295 0.908401725750299 -0.160220522876079 0.822434015414819 miRanda -0.113938449781131 0.0135834120728261 NA NA NA hsa-miR-142-5p APC 1.06109968632125 0.257318725443238 -0.160220522876079 0.822434015414819 mirMAP -0.11397451828566 1.42897915766066e-05 NA NA NA hsa-miR-148a-3p APC -0.336734438265406 0.874732520340819 -0.160220522876079 0.822434015414819 miRNAWalker2_validate -0.148500552905936 1.30504056888118e-07 NA NA NA hsa-miR-182-5p APC 1.43665900078936 0.443507432581923 -0.160220522876079 0.822434015414819 MirTarget -0.148184063767302 6.76984255820765e-10 NA NA NA hsa-miR-186-5p APC 0.273626466122302 0.807169118774403 -0.160220522876079 0.822434015414819 miRNAWalker2_validate -0.284944181200009 7.15520011566402e-09 NA NA NA hsa-miR-193a-3p APC 0.125692968009939 0.782518392846951 -0.160220522876079 0.822434015414819 miRanda -0.164418842739438 0.000289764069991435 NA NA NA hsa-miR-27a-3p APC 0.505339123854064 0.734502884016765 -0.160220522876079 0.822434015414819 miRNAWalker2_validate;miRTarBase;miRNATAP -0.285087982845512 2.6130215532853e-07 22018270 Finally the APC gene was identified as the direct and functional target of miR-27 gastric cancer hsa-miR-27b-3p APC -0.493080552908816 0.742657957939545 -0.160220522876079 0.822434015414819 miRNATAP -0.191438605677929 0.00158194629439779 22018270 Finally the APC gene was identified as the direct and functional target of miR-27 gastric cancer hsa-miR-30d-3p APC -0.0804985653060761 0.825203889451817 -0.160220522876079 0.822434015414819 MirTarget;miRNATAP -0.103102063018262 0.0300872801017096 NA NA NA hsa-miR-30e-3p APC -0.528630634076661 0.752496184625955 -0.160220522876079 0.822434015414819 MirTarget -0.19558841082287 0.00111880627427502 NA NA NA hsa-miR-320a APC 0.22287875340213 0.865731646872282 -0.160220522876079 0.822434015414819 miRanda -0.171768009779629 9.07554255879977e-05 NA NA NA hsa-miR-320b APC 0.941267876385794 0.0453505938355543 -0.160220522876079 0.822434015414819 miRanda -0.186909439259683 1.78577809846012e-10 NA NA NA hsa-miR-330-3p APC 0.237023779714759 0.466174401969581 -0.160220522876079 0.822434015414819 PITA;mirMAP -0.163825832648175 1.47763111005599e-05 NA NA NA hsa-miR-374a-5p APC 0.280580933704653 0.711312203580958 -0.160220522876079 0.822434015414819 mirMAP -0.221525436964822 0.00363827592643693 NA NA NA hsa-miR-374b-5p APC 0.00830204566239612 0.992518773949115 -0.160220522876079 0.822434015414819 mirMAP -0.247402730977334 1.10628245010052e-05 NA NA NA hsa-miR-421 APC 1.28183445098144 3.9841687793795e-06 -0.160220522876079 0.822434015414819 miRanda -0.166401712899035 2.97839785743551e-07 NA NA NA hsa-miR-450b-5p APC 1.31989436603254 0.00773738577557236 -0.160220522876079 0.822434015414819 miRNATAP -0.107212823068897 0.00225890254643388 NA NA NA hsa-miR-501-3p APC 1.73058403233275 0.0341144346170376 -0.160220522876079 0.822434015414819 TargetScan -0.150014553023721 2.75358156752535e-07 NA NA NA hsa-miR-589-3p APC 0.91523747397743 0.0032660296472646 -0.160220522876079 0.822434015414819 MirTarget -0.107663804563015 0.000515625875566821 NA NA NA hsa-miR-590-3p APC 0.750834112502691 0.0721409718537464 -0.160220522876079 0.822434015414819 PITA;miRanda;mirMAP;miRNATAP -0.228122191836907 1.88934488541808e-12 NA NA NA hsa-miR-7-1-3p APC 0.642828512342857 0.399017154673609 -0.160220522876079 0.822434015414819 MirTarget -0.161936289621624 1.66387372226487e-07 NA NA NA hsa-miR-185-5p APC2 1.18682153408723 0.147831753479942 -0.124593018828882 0.723156849265625 miRNATAP -0.12403063714319 0.0435469041802657 NA NA NA hsa-miR-3065-3p APC2 -0.197794429392733 0.754878791884796 -0.124593018828882 0.723156849265625 MirTarget -0.131141529462359 0.000422330629155326 NA NA NA hsa-let-7a-3p AXIN2 0.180588894055192 0.807497649839616 -0.098134936481312 0.888027522621815 miRNATAP -0.210846964955364 0.0255140950284204 NA NA NA hsa-miR-16-2-3p AXIN2 0.73180598347188 0.153070057533699 -0.098134936481312 0.888027522621815 mirMAP -0.158776083133418 0.0172853496977945 NA NA NA hsa-miR-26b-3p AXIN2 0.189972507055099 0.7740623413589 -0.098134936481312 0.888027522621815 MirTarget -0.141827193289527 0.0285361936931712 NA NA NA hsa-miR-29a-5p AXIN2 0.868963854135301 0.0539172641542065 -0.098134936481312 0.888027522621815 MirTarget -0.190952829973355 0.0261054717553858 NA NA NA hsa-miR-326 AXIN2 -0.686277598234758 0.130157755184283 -0.098134936481312 0.888027522621815 miRanda -0.147274284904985 0.0232474454603762 NA NA NA hsa-miR-338-5p AXIN2 -0.469049655008503 0.337730514093722 -0.098134936481312 0.888027522621815 miRNATAP -0.159544273948899 0.0428804372171868 NA NA NA hsa-miR-582-5p AXIN2 -0.0750818699965312 0.895875799292592 -0.098134936481312 0.888027522621815 miRNATAP -0.269615653187287 0.00133971925990498 NA NA NA hsa-miR-130a-3p BTRC 0.410890280285832 0.607447245204235 0.0146906740162462 0.980428098328257 mirMAP -0.102015990061121 4.78317106332123e-05 NA NA NA hsa-miR-15b-5p BTRC 0.441873888832829 0.683456288766732 0.0146906740162462 0.980428098328257 MirTarget;miRNATAP -0.119935391589234 6.91027083024057e-06 NA NA NA hsa-miR-16-5p BTRC 0.294875982844909 0.811640142720194 0.0146906740162462 0.980428098328257 miRNAWalker2_validate;MirTarget;miRNATAP -0.132845602675406 1.10929984506892e-08 NA NA NA hsa-miR-186-5p BTRC 0.273626466122302 0.807169118774403 0.0146906740162462 0.980428098328257 mirMAP -0.154886673913506 2.36368649015955e-06 NA NA NA hsa-miR-22-5p BTRC 0.563707897845906 0.429790318970966 0.0146906740162462 0.980428098328257 miRNATAP -0.137338501777868 9.97332363739444e-09 NA NA NA hsa-miR-330-5p BTRC 0.522359698833297 0.46945472961169 0.0146906740162462 0.980428098328257 miRNATAP -0.102325755802782 2.48793788241715e-05 NA NA NA hsa-miR-342-3p BTRC 0.35619281153521 0.696985677902105 0.0146906740162462 0.980428098328257 mirMAP -0.104262275532957 2.94023249847546e-06 NA NA NA hsa-miR-424-5p BTRC 0.778229637040266 0.39502076082444 0.0146906740162462 0.980428098328257 MirTarget;miRNATAP -0.118135018967481 4.64873694672962e-11 NA NA NA hsa-miR-454-3p BTRC 0.737467730442439 0.0944172375936656 0.0146906740162462 0.980428098328257 mirMAP -0.119196686601231 4.38570205208959e-06 NA NA NA hsa-miR-497-5p BTRC -0.365153126703569 0.562708968911863 0.0146906740162462 0.980428098328257 MirTarget;miRNATAP -0.118257104177209 7.58074321861639e-06 NA NA NA hsa-miR-505-3p BTRC 0.562949148550054 0.467734180580651 0.0146906740162462 0.980428098328257 MirTarget -0.124337338778101 8.50673900908104e-09 NA NA NA hsa-miR-590-3p BTRC 0.750834112502691 0.0721409718537464 0.0146906740162462 0.980428098328257 mirMAP -0.114934739814541 1.35271468937804e-07 NA NA NA hsa-miR-195-3p CACYBP -0.522236286339218 0.0566853778570702 0.556978748791569 0.501148241138556 mirMAP -0.262516864092019 5.72340719115165e-14 NA NA NA hsa-miR-30a-3p CACYBP -1.21767477941485 0.437259873660328 0.556978748791569 0.501148241138556 MirTarget -0.244242794177997 3.2861919917917e-17 NA NA NA hsa-miR-30e-3p CACYBP -0.528630634076661 0.752496184625955 0.556978748791569 0.501148241138556 MirTarget -0.180449196460076 0.000882691979999615 NA NA NA hsa-miR-130b-5p CAMK2A 1.29600920697695 0.0255462581963971 -0.999741389417202 0.0267044463168935 mirMAP -0.672225882814143 2.16734628842583e-24 NA NA NA hsa-miR-142-5p CAMK2A 1.06109968632125 0.257318725443238 -0.999741389417202 0.0267044463168935 PITA;miRNATAP -0.551134921023564 9.20991886659858e-14 NA NA NA hsa-miR-144-3p CAMK2A -1.35523948089606 0.00271266747925526 -0.999741389417202 0.0267044463168935 mirMAP -0.236547158771376 0.000255832527257956 NA NA NA hsa-miR-146b-3p CAMK2A 2.20932741242973 0.0129642965316297 -0.999741389417202 0.0267044463168935 miRNATAP -0.514934647751306 2.53381652999357e-08 NA NA NA hsa-miR-148a-3p CAMK2A -0.336734438265406 0.874732520340819 -0.999741389417202 0.0267044463168935 miRNATAP -0.645875274149976 3.17031006754226e-16 NA NA NA hsa-miR-148b-5p CAMK2A 0.572058810509307 0.0857637180513597 -0.999741389417202 0.0267044463168935 mirMAP -0.617696150845006 5.57765430968239e-14 NA NA NA hsa-miR-15b-3p CAMK2A 0.616287210571229 0.422509520506848 -0.999741389417202 0.0267044463168935 mirMAP -0.858641953736479 8.11504265572324e-26 NA NA NA hsa-miR-185-5p CAMK2A 1.18682153408723 0.147831753479942 -0.999741389417202 0.0267044463168935 mirMAP -1.14358029019507 2.07764312660016e-18 NA NA NA hsa-miR-19b-1-5p CAMK2A 1.68690066069614 0.001519169322997 -0.999741389417202 0.0267044463168935 mirMAP -0.735771886935288 1.57829774799269e-17 NA NA NA hsa-miR-21-3p CAMK2A 1.74562165194276 0.287275799258641 -0.999741389417202 0.0267044463168935 MirTarget -0.750665975369123 6.11436119189796e-18 NA NA NA hsa-miR-25-3p CAMK2A 0.850158516705894 0.641399047473048 -0.999741389417202 0.0267044463168935 MirTarget -0.837420231080539 1.60242505431239e-10 NA NA NA hsa-miR-26a-5p CAMK2A -0.459645668105514 0.761702789258103 -0.999741389417202 0.0267044463168935 miRNATAP -0.445910449307063 0.0151241060916001 NA NA NA hsa-miR-26b-5p CAMK2A -0.640970973524183 0.623642285963207 -0.999741389417202 0.0267044463168935 miRNATAP -0.568455838848084 2.2528214643621e-07 NA NA NA hsa-miR-27a-3p CAMK2A 0.505339123854064 0.734502884016765 -0.999741389417202 0.0267044463168935 mirMAP;miRNATAP -0.99012401918565 5.39452525361253e-10 NA NA NA hsa-miR-30b-5p CAMK2A -0.124247247359659 0.917685196303453 -0.999741389417202 0.0267044463168935 mirMAP -0.394821521500061 0.000794517673155502 NA NA NA hsa-miR-30d-5p CAMK2A 0.218119609086939 0.898751473051369 -0.999741389417202 0.0267044463168935 mirMAP -0.732368692127151 0.000127746910912095 NA NA NA hsa-miR-30e-5p CAMK2A -0.318933868943279 0.850982406429589 -0.999741389417202 0.0267044463168935 mirMAP -1.12098203407806 5.01777627414948e-13 NA NA NA hsa-miR-32-5p CAMK2A 0.32053379451716 0.662616774636995 -0.999741389417202 0.0267044463168935 MirTarget -0.840682941076176 8.85281406455599e-17 NA NA NA hsa-miR-331-3p CAMK2A 0.842954893306256 0.176786083671554 -0.999741389417202 0.0267044463168935 MirTarget -0.617026789729891 2.71581564089409e-11 NA NA NA hsa-miR-335-5p CAMK2A 0.484676450705085 0.267046535449854 -0.999741389417202 0.0267044463168935 mirMAP -0.400703298153041 7.35604816662984e-06 NA NA NA hsa-miR-338-3p CAMK2A -0.0828798547902423 0.951212804477186 -0.999741389417202 0.0267044463168935 miRNATAP -0.192470326345866 0.0291768823201644 NA NA NA hsa-miR-340-5p CAMK2A 0.390142516048182 0.456452075825761 -0.999741389417202 0.0267044463168935 mirMAP -0.326091300899009 0.0383767754618741 NA NA NA hsa-miR-361-3p CAMK2A 0.480275847363033 0.635924490895616 -0.999741389417202 0.0267044463168935 mirMAP -1.07067253834922 6.25335611994198e-13 NA NA NA hsa-miR-3614-5p CAMK2A 0.193652988396427 0.64084696968408 -0.999741389417202 0.0267044463168935 mirMAP -0.515636885111255 6.53202492044413e-11 NA NA NA hsa-miR-3913-5p CAMK2A 1.08617284012911 2.6412048074514e-06 -0.999741389417202 0.0267044463168935 mirMAP -0.269584443765949 0.0333470551031756 NA NA NA hsa-miR-429 CAMK2A 1.19781217693135 0.322310054579944 -0.999741389417202 0.0267044463168935 miRNATAP -0.502269006738758 1.42605585164148e-21 NA NA NA hsa-miR-455-5p CAMK2A 0.610591180666197 0.405984831720842 -0.999741389417202 0.0267044463168935 MirTarget;miRanda -0.619485101906784 6.35015603354695e-10 NA NA NA hsa-miR-625-5p CAMK2A 0.51369754623655 0.274843890626581 -0.999741389417202 0.0267044463168935 mirMAP -0.683542990720171 2.43738360043088e-20 NA NA NA hsa-miR-7-1-3p CAMK2A 0.642828512342857 0.399017154673609 -0.999741389417202 0.0267044463168935 MirTarget -0.718278774645314 1.28276521725851e-16 NA NA NA hsa-miR-92a-3p CAMK2A 0.944279015811086 0.614191641461169 -0.999741389417202 0.0267044463168935 MirTarget -0.767159876338092 4.68914701756927e-13 NA NA NA hsa-miR-92b-3p CAMK2A 1.05220938733495 0.263729863193421 -0.999741389417202 0.0267044463168935 MirTarget -0.451457271846843 0.000201727968607514 NA NA NA hsa-miR-182-5p CAMK2B 1.43665900078936 0.443507432581923 -1.98727192502052 0.000189437049423255 mirMAP -0.466476308439982 6.56939881612247e-09 NA NA NA hsa-miR-186-5p CAMK2B 0.273626466122302 0.807169118774403 -1.98727192502052 0.000189437049423255 miRNAWalker2_validate;miRNATAP -0.671518780024877 5.72329552776472e-05 NA NA NA hsa-miR-18a-5p CAMK2B 1.93049155460812 0.00663833971152871 -1.98727192502052 0.000189437049423255 mirMAP -0.328350190786899 8.14906622742488e-05 NA NA NA hsa-miR-193b-3p CAMK2B 0.0161770988395791 0.982986487056008 -1.98727192502052 0.000189437049423255 mirMAP -0.357681036559251 0.00179985739102564 NA NA NA hsa-miR-24-3p CAMK2B 0.354839860104953 0.813951308530073 -1.98727192502052 0.000189437049423255 MirTarget -0.702426263701843 0.000252909742513884 NA NA NA hsa-miR-29a-3p CAMK2B -0.289266265366038 0.873126628905318 -1.98727192502052 0.000189437049423255 mirMAP -0.41431452274156 0.0104761452432611 NA NA NA hsa-miR-29b-3p CAMK2B -0.0266375641487411 0.98423866564075 -1.98727192502052 0.000189437049423255 mirMAP -0.440409465931373 0.000277842364671055 NA NA NA hsa-miR-335-5p CAMK2B 0.484676450705085 0.267046535449854 -1.98727192502052 0.000189437049423255 mirMAP -0.311712323473231 0.00256503928809914 NA NA NA hsa-miR-34a-5p CAMK2B 0.563661494017221 0.590317849063448 -1.98727192502052 0.000189437049423255 mirMAP -0.58849665397272 1.3846994781504e-06 NA NA NA hsa-miR-362-3p CAMK2B 0.888146502223775 0.0147453056709009 -1.98727192502052 0.000189437049423255 miRanda -0.489030043744917 3.19873259344948e-06 NA NA NA hsa-miR-362-5p CAMK2B 1.36961823784152 0.0184116687226066 -1.98727192502052 0.000189437049423255 miRNATAP -0.454079204076463 2.2878992547717e-06 NA NA NA hsa-miR-577 CAMK2B 0.356857462342957 0.638858200569284 -1.98727192502052 0.000189437049423255 miRNATAP -0.164618695022244 0.0033209364752976 NA NA NA hsa-miR-589-3p CAMK2B 0.91523747397743 0.0032660296472646 -1.98727192502052 0.000189437049423255 MirTarget -0.558306007193065 3.96478535172933e-08 NA NA NA hsa-miR-590-3p CAMK2B 0.750834112502691 0.0721409718537464 -1.98727192502052 0.000189437049423255 miRanda -0.604125318769764 3.96200226071491e-08 NA NA NA hsa-miR-625-5p CAMK2B 0.51369754623655 0.274843890626581 -1.98727192502052 0.000189437049423255 mirMAP -0.588282223260755 2.13902113752437e-11 NA NA NA hsa-miR-628-5p CAMK2B -0.147840687690768 0.737579441803487 -1.98727192502052 0.000189437049423255 miRNATAP -0.314975660934915 0.0175327397759777 NA NA NA hsa-miR-940 CAMK2B 1.13111289289361 0.0032414719740783 -1.98727192502052 0.000189437049423255 PITA;miRNATAP -0.278268177718285 0.000841722286276466 NA NA NA hsa-miR-96-5p CAMK2B 1.14766037573765 0.0779994051337465 -1.98727192502052 0.000189437049423255 mirMAP -0.420481151790776 2.19347978566282e-07 NA NA NA hsa-miR-126-5p CAMK2D 0.393018523145496 0.713269992183763 -0.505256313531621 0.518532771743481 mirMAP -0.127045699766765 0.000841850739296814 NA NA NA hsa-miR-27a-3p CAMK2D 0.505339123854064 0.734502884016765 -0.505256313531621 0.518532771743481 miRNATAP -0.148120693868193 0.00311978088373247 NA NA NA hsa-miR-34c-5p CAMK2D 1.52472702454739 1.53759503188217e-07 -0.505256313531621 0.518532771743481 miRanda -0.103357826540748 0.000381303794962445 NA NA NA hsa-miR-450b-5p CAMK2D 1.31989436603254 0.00773738577557236 -0.505256313531621 0.518532771743481 mirMAP -0.122606469427205 7.9268056251103e-05 NA NA NA hsa-miR-495-3p CAMK2D -0.0502636491763475 0.910413613991017 -0.505256313531621 0.518532771743481 mirMAP -0.117727317724131 0.000847375574051333 NA NA NA hsa-miR-542-3p CAMK2D 1.09096556479387 0.289651874996689 -0.505256313531621 0.518532771743481 miRanda -0.141594554724849 0.000609266635024087 NA NA NA hsa-miR-107 CAMK2G 0.808649908398562 0.357609254490153 -0.463831456578188 0.551362669442477 miRNATAP -0.483274854670543 4.12491586976299e-12 NA NA NA hsa-miR-10b-5p CAMK2G -0.349066414045252 0.854598143201285 -0.463831456578188 0.551362669442477 MirTarget;miRNATAP -0.228505085898917 2.49163502106935e-05 NA NA NA hsa-miR-125a-3p CAMK2G 0.149355443004115 0.640969561382793 -0.463831456578188 0.551362669442477 miRanda -0.141763096618775 0.00121833584328506 NA NA NA hsa-miR-127-5p CAMK2G 0.831883513783777 0.426576346713077 -0.463831456578188 0.551362669442477 MirTarget;PITA;miRNATAP -0.259314634333649 3.66964227996731e-10 NA NA NA hsa-miR-148b-5p CAMK2G 0.572058810509307 0.0857637180513597 -0.463831456578188 0.551362669442477 mirMAP -0.252694001874349 2.34933916522457e-13 NA NA NA hsa-miR-154-5p CAMK2G 0.137785130821394 0.696984789390429 -0.463831456578188 0.551362669442477 MirTarget;miRNATAP -0.184186710943857 1.42773267101438e-05 NA NA NA hsa-miR-16-2-3p CAMK2G 0.73180598347188 0.153070057533699 -0.463831456578188 0.551362669442477 mirMAP -0.328294566612151 7.41518091693832e-24 NA NA NA hsa-miR-16-5p CAMK2G 0.294875982844909 0.811640142720194 -0.463831456578188 0.551362669442477 miRNAWalker2_validate -0.43553950276555 5.59199309165606e-28 NA NA NA hsa-miR-17-3p CAMK2G 1.29395595671088 0.285254165683477 -0.463831456578188 0.551362669442477 miRNATAP -0.302810764489379 1.81904972817241e-11 NA NA NA hsa-miR-181a-5p CAMK2G 1.4443526859599 0.296372990368445 -0.463831456578188 0.551362669442477 miRNATAP -0.280008166168444 6.72544760111625e-08 NA NA NA hsa-miR-181b-5p CAMK2G 1.46153693463023 0.179461012757425 -0.463831456578188 0.551362669442477 miRNATAP -0.241115444207476 2.80340948813089e-07 NA NA NA hsa-miR-185-3p CAMK2G 1.29970093498066 0.00088003078050264 -0.463831456578188 0.551362669442477 MirTarget;miRNATAP -0.339714801045255 7.36339502827227e-18 NA NA NA hsa-miR-194-5p CAMK2G 1.98051780248547 0.297931251695511 -0.463831456578188 0.551362669442477 miRNATAP -0.154031309366531 7.39377580924271e-10 NA NA NA hsa-miR-1976 CAMK2G 0.789785650452199 0.0990760500738296 -0.463831456578188 0.551362669442477 MirTarget -0.383084081321423 5.80593198530374e-19 NA NA NA hsa-miR-29a-3p CAMK2G -0.289266265366038 0.873126628905318 -0.463831456578188 0.551362669442477 miRNATAP -0.301723795684268 2.04047010950051e-07 NA NA NA hsa-miR-29b-3p CAMK2G -0.0266375641487411 0.98423866564075 -0.463831456578188 0.551362669442477 miRNATAP -0.265571591152911 8.7032998447187e-10 NA NA NA hsa-miR-3065-3p CAMK2G -0.197794429392733 0.754878791884796 -0.463831456578188 0.551362669442477 MirTarget;miRNATAP -0.128587053863207 0.000279355447475915 NA NA NA hsa-miR-30d-3p CAMK2G -0.0804985653060761 0.825203889451817 -0.463831456578188 0.551362669442477 MirTarget -0.195003096827955 0.000712422213282177 NA NA NA hsa-miR-30e-3p CAMK2G -0.528630634076661 0.752496184625955 -0.463831456578188 0.551362669442477 MirTarget -0.195145420758727 0.00789205650013159 NA NA NA hsa-miR-320a CAMK2G 0.22287875340213 0.865731646872282 -0.463831456578188 0.551362669442477 miRanda -0.163307159488053 0.0024195381694549 NA NA NA hsa-miR-320b CAMK2G 0.941267876385794 0.0453505938355543 -0.463831456578188 0.551362669442477 miRanda -0.257254561547459 3.33746148175084e-13 NA NA NA hsa-miR-330-3p CAMK2G 0.237023779714759 0.466174401969581 -0.463831456578188 0.551362669442477 PITA;mirMAP -0.346193773125199 5.97249086980949e-15 NA NA NA hsa-miR-331-3p CAMK2G 0.842954893306256 0.176786083671554 -0.463831456578188 0.551362669442477 miRNAWalker2_validate -0.286907143122973 7.54745195373797e-14 NA NA NA hsa-miR-337-3p CAMK2G -0.200974746298455 0.76060131904003 -0.463831456578188 0.551362669442477 PITA -0.146380763637653 0.000461431239081204 NA NA NA hsa-miR-33a-5p CAMK2G 0.179538686749402 0.795042829975416 -0.463831456578188 0.551362669442477 miRNATAP -0.176477798960569 9.97088445709524e-15 NA NA NA hsa-miR-3614-5p CAMK2G 0.193652988396427 0.64084696968408 -0.463831456578188 0.551362669442477 mirMAP;miRNATAP -0.191754040512928 8.91763665888453e-09 NA NA NA hsa-miR-429 CAMK2G 1.19781217693135 0.322310054579944 -0.463831456578188 0.551362669442477 miRNATAP -0.203286260012344 4.93107066063904e-20 NA NA NA hsa-miR-484 CAMK2G 0.340101271888636 0.69389289011036 -0.463831456578188 0.551362669442477 mirMAP -0.33410473240348 1.42061544063953e-14 NA NA NA hsa-miR-493-3p CAMK2G 1.66414810505558 1.78876345541049e-05 -0.463831456578188 0.551362669442477 miRNATAP -0.193637330019283 8.09150222414927e-06 NA NA NA hsa-miR-495-3p CAMK2G -0.0502636491763475 0.910413613991017 -0.463831456578188 0.551362669442477 MirTarget -0.156752105360393 0.00119359790034121 NA NA NA hsa-miR-532-3p CAMK2G 1.13744435296751 0.160148333150432 -0.463831456578188 0.551362669442477 PITA -0.25129762166719 2.77666548001932e-17 NA NA NA hsa-miR-532-5p CAMK2G 1.37200327675848 0.338407542476233 -0.463831456578188 0.551362669442477 MirTarget;PITA;miRNATAP -0.278775003288472 7.69499314747716e-10 NA NA NA hsa-miR-589-3p CAMK2G 0.91523747397743 0.0032660296472646 -0.463831456578188 0.551362669442477 MirTarget -0.208581522713268 1.93935665081212e-08 NA NA NA hsa-miR-590-3p CAMK2G 0.750834112502691 0.0721409718537464 -0.463831456578188 0.551362669442477 miRanda -0.396301591174984 2.42270306291964e-26 NA NA NA hsa-miR-628-5p CAMK2G -0.147840687690768 0.737579441803487 -0.463831456578188 0.551362669442477 MirTarget;PITA;miRNATAP -0.350490645570205 3.32090200070796e-14 NA NA NA hsa-miR-195-5p CCND1 -0.954323940965843 0.175659217190861 0.664037536325998 0.551419562174496 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.270917365501396 6.99604795762646e-06 21350001;26631043;25823925 Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer;MiR 195 inhibits the proliferation of human cervical cancer cells by directly targeting cyclin D1; The present study was to evaluate the level of miR-195 and cyclin D1 in CC tissues and cells; We further investigated the molecular mechanisms of miR-195 and cyclin D1 in CC cell lines HeLa and SiHa; Furthermore the expression of miR-195 was inversely proportional to that of cyclin D1 mRNA or protein p = 0.013 p = 0.015 respectively; However the inhibitor of miR-195 promoted the expression of cyclin D1 and cell proliferation; In conclusion our data suggest that miR-195 may have the potential role in treatment of CC patients as well as miR-195 is a novel regulator of invasiveness and tumorigenicity in CC cells by targeting cyclin D1;MicroRNA profiling identifies MiR 195 suppresses osteosarcoma cell metastasis by targeting CCND1; Meanwhile CCND1 was identified as the target gene of miR-195 and further studied; More importantly using real-time PCR we evaluated the expression of miR-195 and CCND1 in osteosarcoma samples from 107 frozen biopsy tissues and 99 formalin- or paraformalin-fixed paraffin-embedded FFPE tissues; Results indicated lowly expressed miR-195 or highly CCND1 correlated with positive overall survival and their expression inversely related to each other; In summary our study suggests miR-195 functions as a tumor metastasis suppressor gene by down-regulating CCND1 and can be used as a potential target in the treatment of osteosarcoma ;;metastasis;poor survival breast cancer;cervical and endocervical cancer;sarcoma hsa-miR-20b-5p CCND1 0.0507505064661307 0.91631293628579 0.664037536325998 0.551419562174496 MirTarget;miRNATAP -0.181499833751399 1.59769536732368e-05 NA NA NA hsa-miR-29c-3p CCND1 -1.25061656348357 0.418526829407785 0.664037536325998 0.551419562174496 mirMAP -0.156690297682041 0.0103577380850297 NA NA NA hsa-miR-365a-3p CCND1 -0.790131900517861 0.243880854457027 0.664037536325998 0.551419562174496 miRNAWalker2_validate;miRTarBase -0.152931546885566 0.036209208118448 NA NA NA hsa-miR-497-5p CCND1 -0.365153126703569 0.562708968911863 0.664037536325998 0.551419562174496 MirTarget;miRNATAP -0.194638254202971 0.00265856864276364 21350001 Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer breast cancer hsa-miR-9-5p CCND1 -0.699935578986425 0.563236185947538 0.664037536325998 0.551419562174496 miRNAWalker2_validate -0.13860444352194 0.000243216592859737 NA NA NA hsa-let-7a-3p CCND2 0.180588894055192 0.807497649839616 -0.179060107544387 0.84728853614945 mirMAP -0.371567678699036 1.66719392222442e-05 20418948 MicroRNA let 7a inhibits proliferation of human prostate cancer cells in vitro and in vivo by targeting E2F2 and CCND2 prostate cancer hsa-let-7b-3p CCND2 0.273132474559554 0.682533246372485 -0.179060107544387 0.84728853614945 mirMAP -0.402202198292367 0.0006265673802009 NA NA NA hsa-let-7f-1-3p CCND2 1.02975898416111 0.00216616040865014 -0.179060107544387 0.84728853614945 mirMAP -0.421511592056269 1.88495018273279e-06 NA NA NA hsa-let-7f-5p CCND2 0.310417803366471 0.865369307205556 -0.179060107544387 0.84728853614945 miRNATAP -0.346620357429191 0.00536667928289417 NA NA NA hsa-let-7g-5p CCND2 0.242876485228015 0.854288116985674 -0.179060107544387 0.84728853614945 miRNATAP -0.520425112934185 1.17109619787272e-05 NA NA NA hsa-miR-106a-5p CCND2 0.634135628268838 0.223796223760607 -0.179060107544387 0.84728853614945 miRNATAP -0.174204880562388 0.0158246906330611 NA NA NA hsa-miR-106b-5p CCND2 0.947523403196215 0.405863421831729 -0.179060107544387 0.84728853614945 miRNAWalker2_validate;miRTarBase;miRNATAP -0.583236779534434 7.66528568514347e-13 NA NA NA hsa-miR-10b-3p CCND2 0.360517031366521 0.325264998344862 -0.179060107544387 0.84728853614945 mirMAP -0.326004457342762 0.000776508252441517 NA NA NA hsa-miR-130b-5p CCND2 1.29600920697695 0.0255462581963971 -0.179060107544387 0.84728853614945 mirMAP -0.356434702320189 1.36407707081637e-12 NA NA NA hsa-miR-141-3p CCND2 1.38768814668269 0.324793132237099 -0.179060107544387 0.84728853614945 MirTarget;TargetScan -0.255901572354203 1.68526590919642e-09 NA NA NA hsa-miR-151a-3p CCND2 0.851041548487679 0.59138567174135 -0.179060107544387 0.84728853614945 mirMAP -0.530145130595398 2.77401247065126e-06 NA NA NA hsa-miR-15a-5p CCND2 0.999503864534946 0.325292066441584 -0.179060107544387 0.84728853614945 miRNAWalker2_validate;miRTarBase;miRNATAP -0.472165099151573 1.14414004078959e-07 NA NA NA hsa-miR-15b-5p CCND2 0.441873888832829 0.683456288766732 -0.179060107544387 0.84728853614945 miRNATAP -0.516489712340691 8.53499810619317e-10 NA NA NA hsa-miR-16-2-3p CCND2 0.73180598347188 0.153070057533699 -0.179060107544387 0.84728853614945 mirMAP -0.395226309980272 3.27988952149559e-11 NA NA NA hsa-miR-16-5p CCND2 0.294875982844909 0.811640142720194 -0.179060107544387 0.84728853614945 miRNAWalker2_validate;miRNATAP -0.516132357400658 2.11146706317975e-12 NA NA NA hsa-miR-17-5p CCND2 1.42323729519248 0.26500282246461 -0.179060107544387 0.84728853614945 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.301614795379694 2.3679331749879e-06 NA NA NA hsa-miR-181a-2-3p CCND2 0.729676472827631 0.555027073050818 -0.179060107544387 0.84728853614945 mirMAP -0.245234247483269 0.0118441456744301 NA NA NA hsa-miR-182-5p CCND2 1.43665900078936 0.443507432581923 -0.179060107544387 0.84728853614945 miRNAWalker2_validate;miRTarBase;miRNATAP -0.337872116023098 2.21608132770386e-11 NA NA NA hsa-miR-183-5p CCND2 1.7493246062808 0.300980159489712 -0.179060107544387 0.84728853614945 miRNATAP -0.315775206761385 8.35703763428762e-12 NA NA NA hsa-miR-185-5p CCND2 1.18682153408723 0.147831753479942 -0.179060107544387 0.84728853614945 MirTarget;miRNATAP -0.504279725930662 3.95675575027617e-07 NA NA NA hsa-miR-186-5p CCND2 0.273626466122302 0.807169118774403 -0.179060107544387 0.84728853614945 mirMAP;miRNATAP -0.482985631115684 4.61104498921406e-06 NA NA NA hsa-miR-188-5p CCND2 1.39119308895556 0.000791755580412654 -0.179060107544387 0.84728853614945 PITA;mirMAP -0.284821735797616 6.47899773985816e-07 NA NA NA hsa-miR-191-5p CCND2 0.745123588899992 0.563168110159031 -0.179060107544387 0.84728853614945 MirTarget -0.30302138483538 6.11450636907225e-06 NA NA NA hsa-miR-19a-3p CCND2 1.64946154674522 0.0268746411162676 -0.179060107544387 0.84728853614945 MirTarget;miRNATAP -0.266590112566253 9.32456075860399e-06 NA NA NA hsa-miR-19b-3p CCND2 0.806034733762941 0.431963517845538 -0.179060107544387 0.84728853614945 miRNAWalker2_validate;MirTarget;miRNATAP -0.347119617809494 2.8600708950686e-06 NA NA NA hsa-miR-200a-3p CCND2 1.70193303671238 0.209370802942576 -0.179060107544387 0.84728853614945 MirTarget -0.219287797903635 2.3044254482718e-07 NA NA NA hsa-miR-20a-5p CCND2 1.49559512103718 0.20819591223901 -0.179060107544387 0.84728853614945 miRNAWalker2_validate;miRTarBase;miRNATAP -0.225612289455958 0.000751726268016441 NA NA NA hsa-miR-21-3p CCND2 1.74562165194276 0.287275799258641 -0.179060107544387 0.84728853614945 mirMAP -0.307356816380523 3.60292632960926e-06 NA NA NA hsa-miR-2355-3p CCND2 0.0922515944773004 0.789430438736429 -0.179060107544387 0.84728853614945 miRNATAP -0.157835076491116 0.0157147007005435 NA NA NA hsa-miR-26a-2-3p CCND2 0.0416400673740434 0.887900422135032 -0.179060107544387 0.84728853614945 mirMAP -0.182180566976712 0.0217151994827193 NA NA NA hsa-miR-26a-5p CCND2 -0.459645668105514 0.761702789258103 -0.179060107544387 0.84728853614945 miRNAWalker2_validate;miRTarBase;mirMAP;miRNATAP -0.344937807080709 0.00960894332117683 NA NA NA hsa-miR-26b-5p CCND2 -0.640970973524183 0.623642285963207 -0.179060107544387 0.84728853614945 mirMAP;miRNATAP -0.345312855192381 1.73514462922748e-05 NA NA NA hsa-miR-29a-5p CCND2 0.868963854135301 0.0539172641542065 -0.179060107544387 0.84728853614945 mirMAP -0.182159842353673 0.0218809184565078 24130168;22330340 We further demonstrated that miR-29 family acted as tumor suppressors through targeting CCND2 and matrix metalloproteinase-2 genes in GC;In addition to CCND2 miR-29 also targets E2F7 another cell cycle regulator ; gastric cancer;sarcoma hsa-miR-29b-3p CCND2 -0.0266375641487411 0.98423866564075 -0.179060107544387 0.84728853614945 MirTarget;miRNATAP -0.210269851977998 0.00652543437036925 24130168;22330340 We further demonstrated that miR-29 family acted as tumor suppressors through targeting CCND2 and matrix metalloproteinase-2 genes in GC;In addition to CCND2 miR-29 also targets E2F7 another cell cycle regulator ; gastric cancer;sarcoma hsa-miR-301a-3p CCND2 1.18000372861766 0.00831128124191879 -0.179060107544387 0.84728853614945 miRNAWalker2_validate -0.360576735570157 8.69435503941875e-07 NA NA NA hsa-miR-3065-3p CCND2 -0.197794429392733 0.754878791884796 -0.179060107544387 0.84728853614945 MirTarget;miRNATAP -0.195896970627541 0.00146414341100635 NA NA NA hsa-miR-30e-3p CCND2 -0.528630634076661 0.752496184625955 -0.179060107544387 0.84728853614945 mirMAP -0.264578867443002 0.0383806221737476 NA NA NA hsa-miR-320a CCND2 0.22287875340213 0.865731646872282 -0.179060107544387 0.84728853614945 miRNAWalker2_validate;mirMAP;miRNATAP -0.29462773696815 0.0015958349522217 NA NA NA hsa-miR-320b CCND2 0.941267876385794 0.0453505938355543 -0.179060107544387 0.84728853614945 mirMAP;miRNATAP -0.360458427482597 7.75494430819454e-09 NA NA NA hsa-miR-323a-3p CCND2 0.31643910302896 0.392958762081752 -0.179060107544387 0.84728853614945 miRNATAP -0.142895041606599 0.0127859472840689 NA NA NA hsa-miR-324-3p CCND2 0.834250512083397 0.158644323293137 -0.179060107544387 0.84728853614945 miRNAWalker2_validate -0.370821862924607 1.63600931085595e-05 NA NA NA hsa-miR-331-5p CCND2 0.770985543605498 0.00831718947335245 -0.179060107544387 0.84728853614945 miRNATAP -0.460664182751042 5.50959293469208e-07 NA NA NA hsa-miR-335-5p CCND2 0.484676450705085 0.267046535449854 -0.179060107544387 0.84728853614945 miRNAWalker2_validate -0.226680120351377 0.000529223705272384 NA NA NA hsa-miR-33a-3p CCND2 -0.0493858782224366 0.86469054162599 -0.179060107544387 0.84728853614945 MirTarget -0.269105519919619 0.000115590594987793 NA NA NA hsa-miR-3607-3p CCND2 0.402426470225138 0.613303667114625 -0.179060107544387 0.84728853614945 mirMAP -0.119250048528772 0.00252486402934898 NA NA NA hsa-miR-374b-3p CCND2 0.224020026912894 0.351409936209018 -0.179060107544387 0.84728853614945 mirMAP -0.211778548565297 0.00851440143083975 NA NA NA hsa-miR-423-5p CCND2 0.535276881480568 0.51312358537587 -0.179060107544387 0.84728853614945 miRNAWalker2_validate -0.492335489509232 1.57346886934602e-05 NA NA NA hsa-miR-424-5p CCND2 0.778229637040266 0.39502076082444 -0.179060107544387 0.84728853614945 miRNATAP -0.244612937037276 3.39142248190113e-05 NA NA NA hsa-miR-429 CCND2 1.19781217693135 0.322310054579944 -0.179060107544387 0.84728853614945 miRNATAP -0.201473724008651 7.13833700723638e-07 NA NA NA hsa-miR-500a-5p CCND2 1.23668772656115 0.0116556612443014 -0.179060107544387 0.84728853614945 mirMAP -0.313038292150231 1.31135877186835e-07 NA NA NA hsa-miR-501-5p CCND2 1.51510872844603 0.000249681492153084 -0.179060107544387 0.84728853614945 PITA;mirMAP;miRNATAP -0.330162641494821 4.26778581733722e-08 NA NA NA hsa-miR-503-5p CCND2 1.66544059638487 0.000848000297224414 -0.179060107544387 0.84728853614945 MirTarget -0.157878219724021 0.00422430184661587 25860935 We then identified two targets of miR-503 CCND2 and CCND3 breast cancer hsa-miR-550a-5p CCND2 1.32749398544629 0.00261564338014183 -0.179060107544387 0.84728853614945 MirTarget -0.379829000694252 2.57680359355204e-11 NA NA NA hsa-miR-577 CCND2 0.356857462342957 0.638858200569284 -0.179060107544387 0.84728853614945 PITA;mirMAP -0.150091119883405 2.07008309558727e-05 NA NA NA hsa-miR-589-3p CCND2 0.91523747397743 0.0032660296472646 -0.179060107544387 0.84728853614945 mirMAP -0.256663229095903 8.69400409941881e-05 NA NA NA hsa-miR-590-3p CCND2 0.750834112502691 0.0721409718537464 -0.179060107544387 0.84728853614945 miRanda;mirMAP -0.418266898886136 1.66524099584715e-09 NA NA NA hsa-miR-590-5p CCND2 0.763126350124264 0.184296330120049 -0.179060107544387 0.84728853614945 mirMAP -0.356627609219485 6.26678679589055e-08 NA NA NA hsa-miR-660-5p CCND2 1.21674383618366 0.163960898980644 -0.179060107544387 0.84728853614945 mirMAP -0.277964804570177 0.000471101509058194 NA NA NA hsa-miR-7-1-3p CCND2 0.642828512342857 0.399017154673609 -0.179060107544387 0.84728853614945 mirMAP -0.264403230513261 6.47028686057144e-05 NA NA NA hsa-miR-877-5p CCND2 1.7285987615588 2.99444425685028e-06 -0.179060107544387 0.84728853614945 miRNAWalker2_validate -0.320187750770132 3.21509092017468e-09 NA NA NA hsa-miR-93-5p CCND2 1.60480485311451 0.351308047161304 -0.179060107544387 0.84728853614945 miRNATAP -0.296309342090127 2.63797997444733e-05 NA NA NA hsa-miR-96-5p CCND2 1.14766037573765 0.0779994051337465 -0.179060107544387 0.84728853614945 TargetScan;miRNATAP -0.289502666598185 1.60886469433295e-08 NA NA NA hsa-miR-106a-5p CHP2 0.634135628268838 0.223796223760607 -1.90362862823365 0.0258246989334713 MirTarget -0.565465772270169 0.00970598790834211 NA NA NA hsa-miR-20a-5p CHP2 1.49559512103718 0.20819591223901 -1.90362862823365 0.0258246989334713 MirTarget -0.43254758502925 0.0341971898381353 NA NA NA hsa-let-7a-3p CREBBP 0.180588894055192 0.807497649839616 0.22133708215986 0.826215734289203 miRNATAP -0.126832065443874 9.09830479242066e-06 NA NA NA hsa-miR-186-5p CREBBP 0.273626466122302 0.807169118774403 0.22133708215986 0.826215734289203 mirMAP;miRNATAP -0.124895130184274 0.000391994576616712 NA NA NA hsa-miR-26a-5p CREBBP -0.459645668105514 0.761702789258103 0.22133708215986 0.826215734289203 miRNATAP -0.13086170126049 0.00298543969633216 NA NA NA hsa-miR-26b-5p CREBBP -0.640970973524183 0.623642285963207 0.22133708215986 0.826215734289203 miRNATAP -0.114487766466716 1.73366112934079e-05 NA NA NA hsa-miR-330-5p CREBBP 0.522359698833297 0.46945472961169 0.22133708215986 0.826215734289203 miRanda -0.10346690969793 6.3023620889252e-05 NA NA NA hsa-miR-374a-3p CREBBP 0.00444091189256923 0.997279477304268 0.22133708215986 0.826215734289203 miRNATAP -0.168861785882399 2.33223934084548e-05 NA NA NA hsa-miR-590-3p CREBBP 0.750834112502691 0.0721409718537464 0.22133708215986 0.826215734289203 PITA;miRanda;mirMAP;miRNATAP -0.137565790660827 2.28574154348559e-09 NA NA NA hsa-miR-126-5p CSNK1A1 0.393018523145496 0.713269992183763 -0.183979097741121 0.857866985543061 mirMAP -0.108161930171071 6.02908619390026e-05 NA NA NA hsa-miR-186-5p CSNK1A1 0.273626466122302 0.807169118774403 -0.183979097741121 0.857866985543061 miRNAWalker2_validate;miRNATAP -0.101212013319742 0.00150626046978354 NA NA NA hsa-miR-195-5p CSNK1A1 -0.954323940965843 0.175659217190861 -0.183979097741121 0.857866985543061 mirMAP -0.100275752122776 2.7723963145829e-05 NA NA NA hsa-miR-542-3p CSNK1A1 1.09096556479387 0.289651874996689 -0.183979097741121 0.857866985543061 miRanda -0.115984962308073 7.53771910421438e-05 NA NA NA hsa-miR-140-5p CSNK1E 0.0863677120902411 0.909387194440856 0.190227405545968 0.830340788889435 miRanda -0.119571271432892 5.84334355199911e-05 NA NA NA hsa-let-7c-5p CSNK2A1 0.194692337809501 0.890544517884071 0.341561854699275 0.697509541043402 miRNAWalker2_validate -0.110605560014312 1.53680064034306e-06 NA NA NA hsa-miR-125b-5p CSNK2A1 0.127721571299908 0.9163354562791 0.341561854699275 0.697509541043402 MirTarget;miRNATAP -0.127716623375145 3.2138951250996e-07 NA NA NA hsa-miR-143-3p CSNK2A1 -0.761949234880145 0.753966489513053 0.341561854699275 0.697509541043402 MirTarget -0.139743620938889 1.47240031021463e-07 NA NA NA hsa-miR-148a-5p CSNK2A2 -0.0671657147202627 0.935632562211656 -0.0839488813312892 0.897186364342088 mirMAP -0.100041572277835 8.83285965175481e-08 NA NA NA hsa-miR-374a-5p CSNK2A2 0.280580933704653 0.711312203580958 -0.0839488813312892 0.897186364342088 mirMAP -0.116495075997866 0.0169380545589469 NA NA NA hsa-miR-342-3p CTBP2 0.35619281153521 0.696985677902105 0.156909035177973 0.86647708657699 MirTarget;PITA;miRanda;miRNATAP -0.115597652538308 0.000143459567057428 NA NA NA hsa-miR-125a-5p CTNNB1 -0.134418454752295 0.908401725750299 0.340603276114043 0.768177391861667 miRanda -0.100142692543989 0.0200393504736155 NA NA NA hsa-miR-28-5p CTNNB1 -0.182472063669779 0.853776063784381 0.340603276114043 0.768177391861667 miRanda -0.338228704604813 1.00146816885001e-05 NA NA NA hsa-miR-30a-5p CTNNB1 -0.622409301903435 0.733062880166898 0.340603276114043 0.768177391861667 miRNAWalker2_validate -0.17421727504389 6.34577854285267e-06 NA NA NA hsa-miR-92b-3p CTNNBIP1 1.05220938733495 0.263729863193421 -0.775632499340285 0.260675206983883 miRNATAP -0.110887177170583 0.0141092770137079 NA NA NA hsa-let-7a-3p CXXC4 0.180588894055192 0.807497649839616 -0.0972741219376123 0.821289207381177 mirMAP -0.396660671799874 0.000503881433865248 NA NA NA hsa-let-7b-3p CXXC4 0.273132474559554 0.682533246372485 -0.0972741219376123 0.821289207381177 mirMAP -0.693647334686242 5.93538457575092e-06 NA NA NA hsa-let-7f-1-3p CXXC4 1.02975898416111 0.00216616040865014 -0.0972741219376123 0.821289207381177 mirMAP -0.597198848601493 2.46716685023662e-07 NA NA NA hsa-let-7g-3p CXXC4 0.692324017258497 0.345964739358737 -0.0972741219376123 0.821289207381177 MirTarget;miRNATAP -0.229614365192899 0.000708491517575597 NA NA NA hsa-miR-126-5p CXXC4 0.393018523145496 0.713269992183763 -0.0972741219376123 0.821289207381177 MirTarget;mirMAP -0.429412897080193 0.000292919400196972 NA NA NA hsa-miR-130b-3p CXXC4 1.118725142912 0.0736094039162448 -0.0972741219376123 0.821289207381177 miRNATAP -0.260536854859662 0.000619603085556149 NA NA NA hsa-miR-140-5p CXXC4 0.0863677120902411 0.909387194440856 -0.0972741219376123 0.821289207381177 miRanda -0.448627238246744 0.000159869948962423 NA NA NA hsa-miR-141-3p CXXC4 1.38768814668269 0.324793132237099 -0.0972741219376123 0.821289207381177 TargetScan -0.194357886775363 0.000661609969391618 NA NA NA hsa-miR-146a-5p CXXC4 0.67061946633831 0.538820409992621 -0.0972741219376123 0.821289207381177 MirTarget -0.351300783116905 2.13534355010137e-06 NA NA NA hsa-miR-146b-5p CXXC4 2.36576014745762 0.0657344824311623 -0.0972741219376123 0.821289207381177 MirTarget;miRNATAP -0.392787753059881 3.86587285219181e-06 NA NA NA hsa-miR-186-5p CXXC4 0.273626466122302 0.807169118774403 -0.0972741219376123 0.821289207381177 mirMAP -0.383577678817682 0.00622417797650579 NA NA NA hsa-miR-190a-5p CXXC4 -0.121498535316968 0.767260995540885 -0.0972741219376123 0.821289207381177 MirTarget -0.367897795199273 0.000661031389822841 NA NA NA hsa-miR-19b-1-5p CXXC4 1.68690066069614 0.001519169322997 -0.0972741219376123 0.821289207381177 MirTarget -0.320188455705243 0.000232294166126477 NA NA NA hsa-miR-20a-3p CXXC4 0.44568974632412 0.380391798091882 -0.0972741219376123 0.821289207381177 miRNATAP -0.170166554497746 0.0161634112159993 NA NA NA hsa-miR-21-5p CXXC4 2.24244475408756 0.372600191183534 -0.0972741219376123 0.821289207381177 mirMAP -0.403925283977115 0.000548779608354407 NA NA NA hsa-miR-223-3p CXXC4 0.890721687084544 0.45953479560081 -0.0972741219376123 0.821289207381177 MirTarget -0.40849524168773 1.69971947831377e-08 NA NA NA hsa-miR-301a-3p CXXC4 1.18000372861766 0.00831128124191879 -0.0972741219376123 0.821289207381177 miRNATAP -0.200218372130636 0.0412522838087523 NA NA NA hsa-miR-30b-3p CXXC4 0.0708830089216839 0.796242173864443 -0.0972741219376123 0.821289207381177 miRNAWalker2_validate -0.248131198769896 0.0177982491295585 NA NA NA hsa-miR-30e-3p CXXC4 -0.528630634076661 0.752496184625955 -0.0972741219376123 0.821289207381177 mirMAP -0.332470055584682 0.0476142573765511 NA NA NA hsa-miR-338-5p CXXC4 -0.469049655008503 0.337730514093722 -0.0972741219376123 0.821289207381177 MirTarget;miRNATAP -0.199583400056134 0.0372093275490374 NA NA NA hsa-miR-429 CXXC4 1.19781217693135 0.322310054579944 -0.0972741219376123 0.821289207381177 miRNATAP -0.146028738057586 0.00710562882478902 NA NA NA hsa-miR-454-3p CXXC4 0.737467730442439 0.0944172375936656 -0.0972741219376123 0.821289207381177 miRNATAP -0.249563592168926 0.0245899722954058 NA NA NA hsa-miR-501-5p CXXC4 1.51510872844603 0.000249681492153084 -0.0972741219376123 0.821289207381177 mirMAP -0.190195903278389 0.0188350263430437 NA NA NA hsa-miR-532-5p CXXC4 1.37200327675848 0.338407542476233 -0.0972741219376123 0.821289207381177 MirTarget;PITA;miRNATAP -0.345689166341706 0.00109958838571123 NA NA NA hsa-miR-576-5p CXXC4 0.744407899578399 0.146981973135162 -0.0972741219376123 0.821289207381177 mirMAP -0.318317089113384 0.000994666905198248 NA NA NA hsa-miR-582-5p CXXC4 -0.0750818699965312 0.895875799292592 -0.0972741219376123 0.821289207381177 MirTarget;miRNATAP -0.266519603143608 0.00936391863104107 NA NA NA hsa-miR-589-5p CXXC4 1.1821804664823 0.162299570206384 -0.0972741219376123 0.821289207381177 MirTarget;miRNATAP -0.44849955514165 0.00032461820293748 NA NA NA hsa-miR-590-3p CXXC4 0.750834112502691 0.0721409718537464 -0.0972741219376123 0.821289207381177 mirMAP -0.39488267568566 2.04332188326465e-05 NA NA NA hsa-miR-590-5p CXXC4 0.763126350124264 0.184296330120049 -0.0972741219376123 0.821289207381177 mirMAP -0.311991596009941 0.000387295035190866 NA NA NA hsa-miR-660-5p CXXC4 1.21674383618366 0.163960898980644 -0.0972741219376123 0.821289207381177 miRNATAP -0.242870048178983 0.0208128544504533 NA NA NA hsa-miR-7-1-3p CXXC4 0.642828512342857 0.399017154673609 -0.0972741219376123 0.821289207381177 mirMAP -0.314407891768198 0.000309287213069173 NA NA NA hsa-let-7a-3p DAAM1 0.180588894055192 0.807497649839616 -0.275842820324649 0.664914984854105 MirTarget -0.34081358793146 2.13527706890864e-16 NA NA NA hsa-let-7b-3p DAAM1 0.273132474559554 0.682533246372485 -0.275842820324649 0.664914984854105 MirTarget -0.470857695021246 4.2379511295319e-17 NA NA NA hsa-let-7f-1-3p DAAM1 1.02975898416111 0.00216616040865014 -0.275842820324649 0.664914984854105 MirTarget -0.337816772325435 3.44726492839059e-15 NA NA NA hsa-let-7g-3p DAAM1 0.692324017258497 0.345964739358737 -0.275842820324649 0.664914984854105 MirTarget -0.207448720233098 3.11755632370132e-17 NA NA NA hsa-miR-130a-3p DAAM1 0.410890280285832 0.607447245204235 -0.275842820324649 0.664914984854105 MirTarget;miRNATAP -0.131411601833851 0.00125294294812038 NA NA NA hsa-miR-130b-3p DAAM1 1.118725142912 0.0736094039162448 -0.275842820324649 0.664914984854105 MirTarget;miRNATAP -0.262127285563551 3.07628636147256e-22 NA NA NA hsa-miR-130b-5p DAAM1 1.29600920697695 0.0255462581963971 -0.275842820324649 0.664914984854105 MirTarget -0.249696612228163 2.44262363961877e-25 NA NA NA hsa-miR-132-3p DAAM1 0.778103303628054 0.416119200227887 -0.275842820324649 0.664914984854105 MirTarget;miRNATAP -0.277288073946581 8.58778598906924e-06 NA NA NA hsa-miR-140-5p DAAM1 0.0863677120902411 0.909387194440856 -0.275842820324649 0.664914984854105 miRanda -0.312615772831204 1.21788148196119e-12 NA NA NA hsa-miR-142-3p DAAM1 1.85020414100385 0.249422501446635 -0.275842820324649 0.664914984854105 miRanda -0.166232160285356 3.87751483614799e-15 NA NA NA hsa-miR-181a-5p DAAM1 1.4443526859599 0.296372990368445 -0.275842820324649 0.664914984854105 mirMAP -0.179512468802584 9.05965876353712e-05 NA NA NA hsa-miR-181b-5p DAAM1 1.46153693463023 0.179461012757425 -0.275842820324649 0.664914984854105 mirMAP -0.193524659103669 2.5398475793933e-06 NA NA NA hsa-miR-182-5p DAAM1 1.43665900078936 0.443507432581923 -0.275842820324649 0.664914984854105 miRNATAP -0.172226587865744 1.13578378710821e-11 NA NA NA hsa-miR-183-5p DAAM1 1.7493246062808 0.300980159489712 -0.275842820324649 0.664914984854105 MirTarget;miRNATAP -0.166988940738253 5.26454692494801e-13 NA NA NA hsa-miR-186-5p DAAM1 0.273626466122302 0.807169118774403 -0.275842820324649 0.664914984854105 MirTarget;mirMAP -0.426477385541444 3.68659933924329e-17 NA NA NA hsa-miR-194-5p DAAM1 1.98051780248547 0.297931251695511 -0.275842820324649 0.664914984854105 miRNATAP -0.220681237332713 1.5976155130651e-27 NA NA NA hsa-miR-19a-3p DAAM1 1.64946154674522 0.0268746411162676 -0.275842820324649 0.664914984854105 miRNATAP -0.174351657855118 5.19263007567549e-09 NA NA NA hsa-miR-19b-3p DAAM1 0.806034733762941 0.431963517845538 -0.275842820324649 0.664914984854105 miRNATAP -0.223014004496368 1.35057466621383e-09 NA NA NA hsa-miR-21-5p DAAM1 2.24244475408756 0.372600191183534 -0.275842820324649 0.664914984854105 miRNAWalker2_validate -0.191165521420723 1.74085280692908e-05 NA NA NA hsa-miR-212-3p DAAM1 0.895869490569324 0.0316777138361649 -0.275842820324649 0.664914984854105 MirTarget;miRNATAP -0.294463268435113 8.96264734780911e-11 NA NA NA hsa-miR-27a-3p DAAM1 0.505339123854064 0.734502884016765 -0.275842820324649 0.664914984854105 miRNATAP -0.366297121574524 3.14316098014393e-10 NA NA NA hsa-miR-29a-3p DAAM1 -0.289266265366038 0.873126628905318 -0.275842820324649 0.664914984854105 MirTarget;miRNATAP -0.268848442872867 1.09200202656206e-07 NA NA NA hsa-miR-29b-3p DAAM1 -0.0266375641487411 0.98423866564075 -0.275842820324649 0.664914984854105 MirTarget;miRNATAP -0.247439992645264 4.67536895839603e-11 NA NA NA hsa-miR-301a-3p DAAM1 1.18000372861766 0.00831128124191879 -0.275842820324649 0.664914984854105 MirTarget;miRNATAP -0.23505653069086 9.09694213204912e-11 NA NA NA hsa-miR-32-5p DAAM1 0.32053379451716 0.662616774636995 -0.275842820324649 0.664914984854105 miRNATAP -0.270603969093672 5.37915987893771e-13 NA NA NA hsa-miR-320a DAAM1 0.22287875340213 0.865731646872282 -0.275842820324649 0.664914984854105 miRanda -0.138181299408265 0.00328951677031235 NA NA NA hsa-miR-320b DAAM1 0.941267876385794 0.0453505938355543 -0.275842820324649 0.664914984854105 miRanda -0.252584221546055 9.41697507589167e-17 NA NA NA hsa-miR-335-3p DAAM1 2.25543430538924 0.0139006907758541 -0.275842820324649 0.664914984854105 mirMAP -0.137097433432839 1.14416790850049e-06 NA NA NA hsa-miR-335-5p DAAM1 0.484676450705085 0.267046535449854 -0.275842820324649 0.664914984854105 miRNAWalker2_validate;MirTarget;miRNATAP -0.141133744371808 1.58883758757791e-05 NA NA NA hsa-miR-34a-5p DAAM1 0.563661494017221 0.590317849063448 -0.275842820324649 0.664914984854105 MirTarget;miRNATAP -0.271752447296836 7.61626629795046e-13 NA NA NA hsa-miR-362-3p DAAM1 0.888146502223775 0.0147453056709009 -0.275842820324649 0.664914984854105 MirTarget;miRanda;miRNATAP -0.183047207534263 3.67334557713963e-08 NA NA NA hsa-miR-429 DAAM1 1.19781217693135 0.322310054579944 -0.275842820324649 0.664914984854105 miRNATAP -0.179569176060244 1.43980846833316e-20 NA NA NA hsa-miR-454-3p DAAM1 0.737467730442439 0.0944172375936656 -0.275842820324649 0.664914984854105 MirTarget;miRNATAP -0.277402917423282 1.22579416778215e-11 NA NA NA hsa-miR-500a-3p DAAM1 1.37621558353076 0.232455766282991 -0.275842820324649 0.664914984854105 MirTarget -0.217491359016334 2.9892684711599e-10 NA NA NA hsa-miR-576-5p DAAM1 0.744407899578399 0.146981973135162 -0.275842820324649 0.664914984854105 mirMAP -0.271806168998105 1.66562465843357e-14 NA NA NA hsa-miR-577 DAAM1 0.356857462342957 0.638858200569284 -0.275842820324649 0.664914984854105 MirTarget;mirMAP -0.12503338911955 3.26946319535633e-13 NA NA NA hsa-miR-590-3p DAAM1 0.750834112502691 0.0721409718537464 -0.275842820324649 0.664914984854105 MirTarget;miRanda;mirMAP -0.306901205144084 4.02169309506415e-20 NA NA NA hsa-miR-92a-3p DAAM1 0.944279015811086 0.614191641461169 -0.275842820324649 0.664914984854105 miRNATAP -0.223237620000817 1.56759008807828e-08 NA NA NA hsa-miR-92b-3p DAAM1 1.05220938733495 0.263729863193421 -0.275842820324649 0.664914984854105 miRNATAP -0.223295056705818 3.59153280136705e-07 NA NA NA hsa-miR-96-5p DAAM1 1.14766037573765 0.0779994051337465 -0.275842820324649 0.664914984854105 TargetScan;miRNATAP -0.139030923168394 7.52063167875166e-08 NA NA NA hsa-miR-141-5p DAAM2 1.80215279308671 0.171717196416484 -1.13613631884062 0.0821553824300914 mirMAP -0.557709115014348 2.45084210899999e-34 NA NA NA hsa-miR-146b-5p DAAM2 2.36576014745762 0.0657344824311623 -1.13613631884062 0.0821553824300914 miRanda -0.584407132803659 5.05467630024302e-19 NA NA NA hsa-miR-182-5p DAAM2 1.43665900078936 0.443507432581923 -1.13613631884062 0.0821553824300914 mirMAP -0.597931228492072 5.60529626228819e-34 NA NA NA hsa-miR-18a-5p DAAM2 1.93049155460812 0.00663833971152871 -1.13613631884062 0.0821553824300914 miRNAWalker2_validate -0.593477403081751 8.46467621317108e-32 NA NA NA hsa-miR-193a-3p DAAM2 0.125692968009939 0.782518392846951 -1.13613631884062 0.0821553824300914 miRanda -0.392825835089128 0.000125134718842721 NA NA NA hsa-miR-1976 DAAM2 0.789785650452199 0.0990760500738296 -1.13613631884062 0.0821553824300914 mirMAP -0.77542562718764 5.22060024346183e-23 NA NA NA hsa-miR-19b-3p DAAM2 0.806034733762941 0.431963517845538 -1.13613631884062 0.0821553824300914 miRNAWalker2_validate -0.867852590694713 8.11088307156571e-35 NA NA NA hsa-miR-335-5p DAAM2 0.484676450705085 0.267046535449854 -1.13613631884062 0.0821553824300914 mirMAP -0.363177328464158 1.32880448632148e-07 NA NA NA hsa-miR-338-5p DAAM2 -0.469049655008503 0.337730514093722 -1.13613631884062 0.0821553824300914 PITA;miRNATAP -0.243587579862596 0.00167789566452351 NA NA NA hsa-miR-339-5p DAAM2 0.515631910744412 0.482415357074891 -1.13613631884062 0.0821553824300914 miRanda -0.446923176122627 3.22918200717083e-13 NA NA NA hsa-miR-361-3p DAAM2 0.480275847363033 0.635924490895616 -1.13613631884062 0.0821553824300914 mirMAP -0.988274056956583 2.02148981192827e-18 NA NA NA hsa-miR-369-3p DAAM2 0.658307572343713 0.108939404101946 -1.13613631884062 0.0821553824300914 mirMAP -0.426190797980241 7.41253189674476e-07 NA NA NA hsa-miR-421 DAAM2 1.28183445098144 3.9841687793795e-06 -1.13613631884062 0.0821553824300914 PITA;miRanda -0.562199165710436 2.34091673106511e-15 NA NA NA hsa-miR-429 DAAM2 1.19781217693135 0.322310054579944 -1.13613631884062 0.0821553824300914 miRNATAP -0.452956700044708 1.31036217691386e-30 NA NA NA hsa-miR-589-3p DAAM2 0.91523747397743 0.0032660296472646 -1.13613631884062 0.0821553824300914 mirMAP -0.650675769568425 6.90472485904633e-24 NA NA NA hsa-miR-590-3p DAAM2 0.750834112502691 0.0721409718537464 -1.13613631884062 0.0821553824300914 miRanda;mirMAP -0.792383137885389 1.25963176381624e-31 NA NA NA hsa-miR-140-5p DKK2 0.0863677120902411 0.909387194440856 2.62995573417576 2.59044327347953e-11 miRanda -0.369396859400249 0.00249661065872366 NA NA NA hsa-miR-324-5p DKK2 0.707588389659175 0.29394916610875 2.62995573417576 2.59044327347953e-11 miRanda -0.20973774520054 0.0174913254662507 NA NA NA hsa-miR-33a-3p DKK2 -0.0493858782224366 0.86469054162599 2.62995573417576 2.59044327347953e-11 mirMAP -0.383202595963146 4.24898290462031e-05 NA NA NA hsa-miR-3607-3p DKK2 0.402426470225138 0.613303667114625 2.62995573417576 2.59044327347953e-11 miRNATAP -0.145347548899855 0.00622240810874815 NA NA NA hsa-miR-374b-5p DKK2 0.00830204566239612 0.992518773949115 2.62995573417576 2.59044327347953e-11 mirMAP -0.380235472025385 0.0190149580409968 NA NA NA hsa-miR-455-5p DKK2 0.610591180666197 0.405984831720842 2.62995573417576 2.59044327347953e-11 miRanda -0.234902131615945 0.0198395286299192 NA NA NA hsa-miR-486-5p DKK2 -1.48301218922372 0.0956207127449173 2.62995573417576 2.59044327347953e-11 miRanda;miRNATAP -0.453182501293269 9.63299049604481e-09 NA NA NA hsa-miR-576-5p DKK2 0.744407899578399 0.146981973135162 2.62995573417576 2.59044327347953e-11 mirMAP -0.236523026792011 0.0173474258978476 NA NA NA hsa-miR-590-3p DKK2 0.750834112502691 0.0721409718537464 2.62995573417576 2.59044327347953e-11 miRanda;mirMAP;miRNATAP -0.331022399044774 0.000519312757097184 NA NA NA hsa-miR-590-5p DKK2 0.763126350124264 0.184296330120049 2.62995573417576 2.59044327347953e-11 miRanda -0.294972387645381 0.00106204960752677 NA NA NA hsa-miR-25-3p DKK4 0.850158516705894 0.641399047473048 -3.00795592045647 4.63601394956169e-05 miRNAWalker2_validate -0.532764842594441 0.0158022715318034 NA NA NA hsa-miR-27a-3p DVL2 0.505339123854064 0.734502884016765 0.0694931915649635 0.917685721101575 miRNATAP -0.10726305173341 0.00510728391398826 NA NA NA hsa-miR-26a-5p EP300 -0.459645668105514 0.761702789258103 0.184363270158284 0.855523729827614 miRNATAP -0.179040051498714 7.75875796633954e-07 NA NA NA hsa-miR-106b-5p FBXW11 0.947523403196215 0.405863421831729 -0.190280752122221 0.796565949914259 miRNATAP -0.146089339967415 1.48008245446189e-07 NA NA NA hsa-miR-130b-3p FBXW11 1.118725142912 0.0736094039162448 -0.190280752122221 0.796565949914259 MirTarget -0.105731867280225 2.72501712118004e-08 NA NA NA hsa-miR-186-5p FBXW11 0.273626466122302 0.807169118774403 -0.190280752122221 0.796565949914259 mirMAP -0.131356054217081 0.00021264394006778 NA NA NA hsa-miR-199a-3p FBXW11 1.20746327187529 0.434443647645962 -0.190280752122221 0.796565949914259 MirTarget;PITA;miRNATAP -0.111789870938036 0.000789623885338051 NA NA NA hsa-miR-199b-3p FBXW11 1.20816960143913 0.434036915050342 -0.190280752122221 0.796565949914259 MirTarget;PITA;miRNATAP -0.111576670011835 0.000798288437379028 NA NA NA hsa-miR-19b-3p FBXW11 0.806034733762941 0.431963517845538 -0.190280752122221 0.796565949914259 MirTarget -0.103337414934946 3.30157876505128e-05 NA NA NA hsa-miR-320b FBXW11 0.941267876385794 0.0453505938355543 -0.190280752122221 0.796565949914259 PITA;miRanda -0.102643714568954 1.08085956289312e-06 NA NA NA hsa-miR-374a-5p FBXW11 0.280580933704653 0.711312203580958 -0.190280752122221 0.796565949914259 mirMAP -0.167151177090865 0.00189315527538124 NA NA NA hsa-miR-374b-5p FBXW11 0.00830204566239612 0.992518773949115 -0.190280752122221 0.796565949914259 mirMAP -0.197743142499112 5.89987767057284e-07 NA NA NA hsa-miR-505-3p FBXW11 0.562949148550054 0.467734180580651 -0.190280752122221 0.796565949914259 mirMAP -0.113093338117394 1.29139074936535e-06 NA NA NA hsa-miR-590-3p FBXW11 0.750834112502691 0.0721409718537464 -0.190280752122221 0.796565949914259 mirMAP -0.112303279076713 1.73130075144294e-06 NA NA NA hsa-miR-125a-5p FRAT2 -0.134418454752295 0.908401725750299 0.0535537461538773 0.937083087709282 miRanda -0.113104197011069 0.0329081160450467 NA NA NA hsa-miR-125b-5p FRAT2 0.127721571299908 0.9163354562791 0.0535537461538773 0.937083087709282 miRNAWalker2_validate;miRNATAP -0.190363086108397 5.04222936674705e-07 NA NA NA hsa-miR-23b-3p FRAT2 -0.221167036294661 0.878330648681029 0.0535537461538773 0.937083087709282 miRNATAP -0.156747624163848 0.0370471975694573 NA NA NA hsa-miR-146a-5p FZD1 0.67061946633831 0.538820409992621 0.145804678547725 0.838126501337602 MirTarget -0.182572521782456 9.8946354226908e-09 NA NA NA hsa-miR-148b-5p FZD1 0.572058810509307 0.0857637180513597 0.145804678547725 0.838126501337602 MirTarget -0.161484790203855 4.32552887083473e-06 NA NA NA hsa-miR-186-5p FZD1 0.273626466122302 0.807169118774403 0.145804678547725 0.838126501337602 mirMAP -0.270542609246574 6.77828109262551e-06 NA NA NA hsa-miR-192-5p FZD1 1.83864778676109 0.37609734647626 0.145804678547725 0.838126501337602 miRNAWalker2_validate -0.137292935739732 2.00935514333215e-09 NA NA NA hsa-miR-200a-5p FZD1 1.86312609760413 0.20175418094233 0.145804678547725 0.838126501337602 MirTarget -0.126412051792278 1.49326033113079e-06 NA NA NA hsa-miR-200b-5p FZD1 0.523760877034833 0.546561830390861 0.145804678547725 0.838126501337602 MirTarget -0.169121892179877 8.37706940002807e-10 NA NA NA hsa-miR-29a-3p FZD1 -0.289266265366038 0.873126628905318 0.145804678547725 0.838126501337602 mirMAP -0.326805465812611 1.04626026386601e-08 NA NA NA hsa-miR-29b-3p FZD1 -0.0266375641487411 0.98423866564075 0.145804678547725 0.838126501337602 mirMAP -0.253842512356405 3.34322921180402e-09 NA NA NA hsa-miR-29c-3p FZD1 -1.25061656348357 0.418526829407785 0.145804678547725 0.838126501337602 mirMAP -0.123133968718176 0.00745583950090575 NA NA NA hsa-miR-335-5p FZD1 0.484676450705085 0.267046535449854 0.145804678547725 0.838126501337602 miRNAWalker2_validate -0.16075460080393 1.42102755226175e-05 NA NA NA hsa-miR-590-3p FZD1 0.750834112502691 0.0721409718537464 0.145804678547725 0.838126501337602 miRanda -0.250241457206772 2.12838222474708e-10 NA NA NA hsa-miR-93-3p FZD1 1.0379867963088 0.0605530010506672 0.145804678547725 0.838126501337602 MirTarget -0.160710983066684 1.04335492118832e-05 NA NA NA hsa-miR-107 FZD10 0.808649908398562 0.357609254490153 -0.819378635482242 0.0276040632035848 miRanda -0.415652605726841 0.011405925030007 NA NA NA hsa-miR-140-3p FZD10 0.0424028925269262 0.97506468860784 -0.819378635482242 0.0276040632035848 miRNATAP -0.48773951454916 0.00938062007010308 NA NA NA hsa-miR-15a-5p FZD10 0.999503864534946 0.325292066441584 -0.819378635482242 0.0276040632035848 miRNATAP -0.373939349903064 0.00158008537515068 NA NA NA hsa-miR-15b-5p FZD10 0.441873888832829 0.683456288766732 -0.819378635482242 0.0276040632035848 miRNATAP -0.322926293558391 0.00429667245587105 NA NA NA hsa-miR-16-5p FZD10 0.294875982844909 0.811640142720194 -0.819378635482242 0.0276040632035848 miRNATAP -0.26974499680618 0.00688587270078794 NA NA NA hsa-miR-25-3p FZD10 0.850158516705894 0.641399047473048 -0.819378635482242 0.0276040632035848 miRNATAP -0.309624339353374 0.0159000801819509 NA NA NA hsa-miR-455-3p FZD10 0.970088567389584 0.370523301857447 -0.819378635482242 0.0276040632035848 PITA;miRNATAP -0.132205470368284 0.0268624237350404 NA NA NA hsa-miR-92a-3p FZD10 0.944279015811086 0.614191641461169 -0.819378635482242 0.0276040632035848 miRNATAP -0.211427939064962 0.0446188443869235 NA NA NA hsa-miR-92b-3p FZD10 1.05220938733495 0.263729863193421 -0.819378635482242 0.0276040632035848 miRNATAP -0.246316405989251 0.0341458866075461 NA NA NA hsa-let-7a-3p FZD3 0.180588894055192 0.807497649839616 0.0945658911206158 0.883218126248615 MirTarget;miRNATAP -0.327329902345092 5.07635436329011e-07 NA NA NA hsa-let-7b-3p FZD3 0.273132474559554 0.682533246372485 0.0945658911206158 0.883218126248615 MirTarget;miRNATAP -0.383395757633796 1.56840136325192e-05 NA NA NA hsa-let-7b-5p FZD3 0.160946185046312 0.931336709889188 0.0945658911206158 0.883218126248615 MirTarget;miRNATAP -0.24178070273506 0.0205661295067825 NA NA NA hsa-let-7d-5p FZD3 0.556268325000502 0.620991013688543 0.0945658911206158 0.883218126248615 MirTarget;miRNATAP -0.247209116622627 0.00421676278174778 NA NA NA hsa-let-7f-1-3p FZD3 1.02975898416111 0.00216616040865014 0.0945658911206158 0.883218126248615 MirTarget -0.216659162579678 0.00144304479582396 NA NA NA hsa-let-7g-5p FZD3 0.242876485228015 0.854288116985674 0.0945658911206158 0.883218126248615 MirTarget;miRNATAP -0.272999397252577 0.0027269338298238 NA NA NA hsa-miR-106b-5p FZD3 0.947523403196215 0.405863421831729 0.0945658911206158 0.883218126248615 MirTarget;mirMAP;miRNATAP -0.146775012872736 0.0229996897595295 NA NA NA hsa-miR-125a-3p FZD3 0.149355443004115 0.640969561382793 0.0945658911206158 0.883218126248615 mirMAP -0.12437232189316 0.0322790580489796 NA NA NA hsa-miR-126-5p FZD3 0.393018523145496 0.713269992183763 0.0945658911206158 0.883218126248615 mirMAP -0.342367218649761 4.44029410978297e-07 NA NA NA hsa-miR-127-5p FZD3 0.831883513783777 0.426576346713077 0.0945658911206158 0.883218126248615 mirMAP -0.15207311210808 0.00680823390957848 NA NA NA hsa-miR-130b-3p FZD3 1.118725142912 0.0736094039162448 0.0945658911206158 0.883218126248615 mirMAP -0.137672496914354 0.0018063284598782 NA NA NA hsa-miR-140-5p FZD3 0.0863677120902411 0.909387194440856 0.0945658911206158 0.883218126248615 miRanda -0.368508700906069 5.40350878581236e-08 NA NA NA hsa-miR-142-3p FZD3 1.85020414100385 0.249422501446635 0.0945658911206158 0.883218126248615 miRanda -0.149802085034905 6.4114836416828e-06 NA NA NA hsa-miR-146a-5p FZD3 0.67061946633831 0.538820409992621 0.0945658911206158 0.883218126248615 MirTarget -0.19628789095469 4.85353114110974e-06 NA NA NA hsa-miR-146b-5p FZD3 2.36576014745762 0.0657344824311623 0.0945658911206158 0.883218126248615 MirTarget;miRanda -0.145560341953965 0.00346971755194473 NA NA NA hsa-miR-148a-5p FZD3 -0.0671657147202627 0.935632562211656 0.0945658911206158 0.883218126248615 mirMAP -0.139846401504222 0.00355957920290282 NA NA NA hsa-miR-154-5p FZD3 0.137785130821394 0.696984789390429 0.0945658911206158 0.883218126248615 MirTarget -0.157508585002031 0.00533432398803114 NA NA NA hsa-miR-155-5p FZD3 0.689059012865632 0.586621132607867 0.0945658911206158 0.883218126248615 mirMAP -0.300016671253164 2.23070692926437e-11 NA NA NA hsa-miR-16-2-3p FZD3 0.73180598347188 0.153070057533699 0.0945658911206158 0.883218126248615 mirMAP -0.150579812447557 0.00126722857490596 NA NA NA hsa-miR-186-5p FZD3 0.273626466122302 0.807169118774403 0.0945658911206158 0.883218126248615 mirMAP -0.231217527043788 0.00434395885218035 NA NA NA hsa-miR-192-3p FZD3 1.53303749871781 0.126158902379712 0.0945658911206158 0.883218126248615 MirTarget;miRNATAP -0.118795762257092 0.000125471626691302 NA NA NA hsa-miR-200a-5p FZD3 1.86312609760413 0.20175418094233 0.0945658911206158 0.883218126248615 mirMAP -0.111629383139822 0.00164615682581333 NA NA NA hsa-miR-200b-5p FZD3 0.523760877034833 0.546561830390861 0.0945658911206158 0.883218126248615 mirMAP -0.116394145415871 0.00203164918857439 NA NA NA hsa-miR-200c-3p FZD3 1.38059869033872 0.459075461573504 0.0945658911206158 0.883218126248615 mirMAP -0.113793531455101 0.002369145600513 NA NA NA hsa-miR-2355-3p FZD3 0.0922515944773004 0.789430438736429 0.0945658911206158 0.883218126248615 mirMAP -0.197489312484224 5.89867252834181e-05 NA NA NA hsa-miR-23a-3p FZD3 0.727812777693753 0.65239699793942 0.0945658911206158 0.883218126248615 MirTarget -0.296150346585694 0.00578123757170292 NA NA NA hsa-miR-23a-5p FZD3 -0.0416293388235878 0.916416921469514 0.0945658911206158 0.883218126248615 mirMAP -0.164374027907521 5.8251418222055e-05 NA NA NA hsa-miR-27a-3p FZD3 0.505339123854064 0.734502884016765 0.0945658911206158 0.883218126248615 miRNATAP -0.463864516156017 1.84216606299091e-07 NA NA NA hsa-miR-29a-5p FZD3 0.868963854135301 0.0539172641542065 0.0945658911206158 0.883218126248615 mirMAP -0.206374164117865 0.000582485822451235 NA NA NA hsa-miR-30a-3p FZD3 -1.21767477941485 0.437259873660328 0.0945658911206158 0.883218126248615 mirMAP -0.15175353864019 0.00543696626877911 NA NA NA hsa-miR-30b-5p FZD3 -0.124247247359659 0.917685196303453 0.0945658911206158 0.883218126248615 MirTarget -0.16377417015694 0.0120723385047853 NA NA NA hsa-miR-30d-3p FZD3 -0.0804985653060761 0.825203889451817 0.0945658911206158 0.883218126248615 mirMAP -0.161514802611747 0.034613307075314 NA NA NA hsa-miR-30e-3p FZD3 -0.528630634076661 0.752496184625955 0.0945658911206158 0.883218126248615 mirMAP -0.423484565358047 9.60265342350025e-06 NA NA NA hsa-miR-30e-5p FZD3 -0.318933868943279 0.850982406429589 0.0945658911206158 0.883218126248615 MirTarget -0.409898868298691 3.26300064567933e-06 NA NA NA hsa-miR-330-3p FZD3 0.237023779714759 0.466174401969581 0.0945658911206158 0.883218126248615 MirTarget;PITA;miRNATAP -0.203036934130576 0.000916787283140305 NA NA NA hsa-miR-342-3p FZD3 0.35619281153521 0.696985677902105 0.0945658911206158 0.883218126248615 miRanda -0.228730289330473 2.7839777666108e-05 NA NA NA hsa-miR-369-3p FZD3 0.658307572343713 0.108939404101946 0.0945658911206158 0.883218126248615 MirTarget -0.151586039272099 0.0149845104332966 NA NA NA hsa-miR-374a-3p FZD3 0.00444091189256923 0.997279477304268 0.0945658911206158 0.883218126248615 mirMAP -0.188878274197675 0.0415389561475468 NA NA NA hsa-miR-374a-5p FZD3 0.280580933704653 0.711312203580958 0.0945658911206158 0.883218126248615 mirMAP -0.389747525395915 0.00143617167959037 NA NA NA hsa-miR-374b-5p FZD3 0.00830204566239612 0.992518773949115 0.0945658911206158 0.883218126248615 mirMAP -0.251182204007359 0.00605448942722563 NA NA NA hsa-miR-495-3p FZD3 -0.0502636491763475 0.910413613991017 0.0945658911206158 0.883218126248615 mirMAP -0.1413289725212 0.0274766936931306 NA NA NA hsa-miR-505-3p FZD3 0.562949148550054 0.467734180580651 0.0945658911206158 0.883218126248615 mirMAP -0.149661730471711 0.00550122178283088 NA NA NA hsa-miR-590-3p FZD3 0.750834112502691 0.0721409718537464 0.0945658911206158 0.883218126248615 miRanda;mirMAP;miRNATAP -0.246579161580878 4.00048190305727e-06 NA NA NA hsa-miR-625-3p FZD3 0.244901533605015 0.843926802449661 0.0945658911206158 0.883218126248615 mirMAP -0.229782715735278 4.07757034373872e-06 NA NA NA hsa-miR-628-5p FZD3 -0.147840687690768 0.737579441803487 0.0945658911206158 0.883218126248615 miRNATAP -0.267249243618696 2.34680229364556e-05 NA NA NA hsa-miR-664a-3p FZD3 -0.0286436952305813 0.961537804671418 0.0945658911206158 0.883218126248615 MirTarget;mirMAP -0.1720285883188 0.0417398013116709 NA NA NA hsa-miR-7-1-3p FZD3 0.642828512342857 0.399017154673609 0.0945658911206158 0.883218126248615 mirMAP -0.116689031225886 0.021608445805245 NA NA NA hsa-let-7a-3p FZD4 0.180588894055192 0.807497649839616 0.0731935852427092 0.914235907691817 mirMAP -0.324808084626732 2.93680541733312e-10 NA NA NA hsa-let-7b-3p FZD4 0.273132474559554 0.682533246372485 0.0731935852427092 0.914235907691817 mirMAP -0.266452278043024 0.00019371732831142 NA NA NA hsa-let-7d-5p FZD4 0.556268325000502 0.620991013688543 0.0731935852427092 0.914235907691817 MirTarget;miRNATAP -0.360111157558034 1.1743162550452e-07 NA NA NA hsa-let-7f-1-3p FZD4 1.02975898416111 0.00216616040865014 0.0731935852427092 0.914235907691817 mirMAP -0.327301802568543 7.18821983337286e-10 NA NA NA hsa-let-7g-3p FZD4 0.692324017258497 0.345964739358737 0.0731935852427092 0.914235907691817 MirTarget;miRNATAP -0.175259068508466 1.32918235228927e-08 NA NA NA hsa-let-7g-5p FZD4 0.242876485228015 0.854288116985674 0.0731935852427092 0.914235907691817 MirTarget;miRNATAP -0.377022146224796 1.48965719356005e-07 NA NA NA hsa-miR-106b-5p FZD4 0.947523403196215 0.405863421831729 0.0731935852427092 0.914235907691817 miRNATAP -0.408685458706274 4.88615285376528e-17 NA NA NA hsa-miR-107 FZD4 0.808649908398562 0.357609254490153 0.0731935852427092 0.914235907691817 miRNATAP -0.431881074723279 7.30004753044828e-09 NA NA NA hsa-miR-130b-3p FZD4 1.118725142912 0.0736094039162448 0.0731935852427092 0.914235907691817 mirMAP -0.258085894615828 2.27749003589176e-14 NA NA NA hsa-miR-141-3p FZD4 1.38768814668269 0.324793132237099 0.0731935852427092 0.914235907691817 TargetScan -0.233905414653953 2.12659359560773e-21 NA NA NA hsa-miR-144-3p FZD4 -1.35523948089606 0.00271266747925526 0.0731935852427092 0.914235907691817 mirMAP;miRNATAP -0.118284656213038 3.35593097403372e-05 NA NA NA hsa-miR-15a-5p FZD4 0.999503864534946 0.325292066441584 0.0731935852427092 0.914235907691817 MirTarget -0.392519652278322 1.17828271117269e-13 NA NA NA hsa-miR-15b-5p FZD4 0.441873888832829 0.683456288766732 0.0731935852427092 0.914235907691817 MirTarget -0.369374182642617 2.70467087612038e-13 NA NA NA hsa-miR-16-5p FZD4 0.294875982844909 0.811640142720194 0.0731935852427092 0.914235907691817 MirTarget -0.306428305545196 8.38754425500858e-12 NA NA NA hsa-miR-17-3p FZD4 1.29395595671088 0.285254165683477 0.0731935852427092 0.914235907691817 MirTarget -0.361980086120886 1.34744548852313e-14 NA NA NA hsa-miR-17-5p FZD4 1.42323729519248 0.26500282246461 0.0731935852427092 0.914235907691817 TargetScan -0.342114154217989 1.0949714685593e-20 NA NA NA hsa-miR-185-5p FZD4 1.18682153408723 0.147831753479942 0.0731935852427092 0.914235907691817 MirTarget -0.358846719814455 2.2329402381933e-09 NA NA NA hsa-miR-186-5p FZD4 0.273626466122302 0.807169118774403 0.0731935852427092 0.914235907691817 mirMAP -0.3347027043812 1.56811963506979e-07 NA NA NA hsa-miR-192-5p FZD4 1.83864778676109 0.37609734647626 0.0731935852427092 0.914235907691817 miRNAWalker2_validate;mirMAP -0.150355937966884 7.50047534617471e-10 NA NA NA hsa-miR-200b-3p FZD4 1.76966404687048 0.251078084855527 0.0731935852427092 0.914235907691817 mirMAP -0.214778042935168 5.17869105722577e-15 NA NA NA hsa-miR-200c-3p FZD4 1.38059869033872 0.459075461573504 0.0731935852427092 0.914235907691817 mirMAP -0.242447908539678 9.99442607921939e-18 NA NA NA hsa-miR-20a-5p FZD4 1.49559512103718 0.20819591223901 0.0731935852427092 0.914235907691817 miRNATAP -0.316432044597461 3.10696500841379e-16 NA NA NA hsa-miR-21-5p FZD4 2.24244475408756 0.372600191183534 0.0731935852427092 0.914235907691817 mirMAP -0.160516194106593 0.00316148386387969 NA NA NA hsa-miR-22-5p FZD4 0.563707897845906 0.429790318970966 0.0731935852427092 0.914235907691817 mirMAP -0.170975144201316 0.000339684907983994 NA NA NA hsa-miR-24-3p FZD4 0.354839860104953 0.813951308530073 0.0731935852427092 0.914235907691817 miRNAWalker2_validate -0.297471038283336 5.82521545527941e-05 NA NA NA hsa-miR-25-3p FZD4 0.850158516705894 0.641399047473048 0.0731935852427092 0.914235907691817 mirMAP -0.380976645235012 4.32926864258263e-11 NA NA NA hsa-miR-27a-3p FZD4 0.505339123854064 0.734502884016765 0.0731935852427092 0.914235907691817 miRNATAP -0.426922267367871 1.55778864897184e-09 NA NA NA hsa-miR-301a-3p FZD4 1.18000372861766 0.00831128124191879 0.0731935852427092 0.914235907691817 mirMAP -0.281004384724101 1.63731882709913e-10 NA NA NA hsa-miR-3127-5p FZD4 1.07283726006422 0.00620209739135467 0.0731935852427092 0.914235907691817 MirTarget -0.289370691548835 5.64796479082419e-15 NA NA NA hsa-miR-32-5p FZD4 0.32053379451716 0.662616774636995 0.0731935852427092 0.914235907691817 mirMAP -0.318680134024363 2.60694227715029e-12 NA NA NA hsa-miR-324-3p FZD4 0.834250512083397 0.158644323293137 0.0731935852427092 0.914235907691817 miRNATAP -0.326891513904809 1.94029661921225e-10 NA NA NA hsa-miR-330-5p FZD4 0.522359698833297 0.46945472961169 0.0731935852427092 0.914235907691817 miRanda;miRNATAP -0.224799874457011 1.92420541251544e-06 NA NA NA hsa-miR-33a-3p FZD4 -0.0493858782224366 0.86469054162599 0.0731935852427092 0.914235907691817 mirMAP -0.282022030717473 8.31353023904281e-12 NA NA NA hsa-miR-361-3p FZD4 0.480275847363033 0.635924490895616 0.0731935852427092 0.914235907691817 MirTarget -0.234836495370281 0.000589096404222634 NA NA NA hsa-miR-361-5p FZD4 0.517068298358111 0.640548482802509 0.0731935852427092 0.914235907691817 mirMAP -0.253551025298772 0.00877076618393681 NA NA NA hsa-miR-424-5p FZD4 0.778229637040266 0.39502076082444 0.0731935852427092 0.914235907691817 MirTarget -0.128857676235156 0.000356976793821815 NA NA NA hsa-miR-429 FZD4 1.19781217693135 0.322310054579944 0.0731935852427092 0.914235907691817 mirMAP -0.188203241385095 3.5350635965777e-15 NA NA NA hsa-miR-452-5p FZD4 0.554766385459708 0.461430383959838 0.0731935852427092 0.914235907691817 miRNATAP -0.103443004285533 0.0109362307065371 NA NA NA hsa-miR-454-3p FZD4 0.737467730442439 0.0944172375936656 0.0731935852427092 0.914235907691817 mirMAP -0.280364016174149 2.41405996585837e-08 NA NA NA hsa-miR-455-3p FZD4 0.970088567389584 0.370523301857447 0.0731935852427092 0.914235907691817 mirMAP -0.16427833888173 1.20050235981238e-09 NA NA NA hsa-miR-484 FZD4 0.340101271888636 0.69389289011036 0.0731935852427092 0.914235907691817 PITA -0.263602750956226 2.16114738820064e-08 NA NA NA hsa-miR-505-5p FZD4 0.423657953607018 0.332788995145813 0.0731935852427092 0.914235907691817 MirTarget -0.151177090287792 0.000240942065206585 NA NA NA hsa-miR-508-3p FZD4 1.19153880098998 0.00809642417039462 0.0731935852427092 0.914235907691817 miRNATAP -0.107750619492054 0.000158121506303209 NA NA NA hsa-miR-576-5p FZD4 0.744407899578399 0.146981973135162 0.0731935852427092 0.914235907691817 mirMAP -0.341566082221553 1.22639050070457e-15 NA NA NA hsa-miR-582-5p FZD4 -0.0750818699965312 0.895875799292592 0.0731935852427092 0.914235907691817 PITA;miRNATAP -0.234619729016311 5.22320052673761e-07 NA NA NA hsa-miR-589-3p FZD4 0.91523747397743 0.0032660296472646 0.0731935852427092 0.914235907691817 mirMAP -0.272835492738442 1.51180701703617e-12 NA NA NA hsa-miR-590-3p FZD4 0.750834112502691 0.0721409718537464 0.0731935852427092 0.914235907691817 miRanda;mirMAP;miRNATAP -0.321737975495561 7.03101220458757e-15 NA NA NA hsa-miR-590-5p FZD4 0.763126350124264 0.184296330120049 0.0731935852427092 0.914235907691817 mirMAP -0.298046672945044 2.43918218778573e-14 NA NA NA hsa-miR-629-3p FZD4 0.551260052178687 0.20899418574898 0.0731935852427092 0.914235907691817 miRNATAP -0.231492472332078 2.07611984916361e-12 NA NA NA hsa-miR-7-1-3p FZD4 0.642828512342857 0.399017154673609 0.0731935852427092 0.914235907691817 mirMAP -0.280881863476872 5.82342226918926e-13 NA NA NA hsa-miR-874-3p FZD4 0.265736350867548 0.667951038921162 0.0731935852427092 0.914235907691817 MirTarget -0.126767181690515 0.00617480575758279 NA NA NA hsa-miR-92a-3p FZD4 0.944279015811086 0.614191641461169 0.0731935852427092 0.914235907691817 mirMAP -0.404905979148078 9.92753152773345e-19 NA NA NA hsa-miR-92b-3p FZD4 1.05220938733495 0.263729863193421 0.0731935852427092 0.914235907691817 mirMAP -0.137352842742536 0.0111362024190549 NA NA NA hsa-miR-935 FZD4 2.18097631134671 4.12025538006203e-05 0.0731935852427092 0.914235907691817 PITA;miRNATAP -0.119590792309579 1.33801812051025e-07 NA NA NA hsa-miR-940 FZD4 1.13111289289361 0.0032414719740783 0.0731935852427092 0.914235907691817 miRNATAP -0.161851159056007 3.49474479096693e-07 NA NA NA hsa-miR-98-5p FZD4 0.653130521360138 0.419258665684676 0.0731935852427092 0.914235907691817 MirTarget -0.396091628983116 1.27002213375406e-06 NA NA NA hsa-miR-100-5p FZD5 -0.0583681430393437 0.970510217435785 0.0312900090210482 0.972223037324197 MirTarget;miRNATAP -0.194092916998091 1.74798465334395e-05 NA NA NA hsa-miR-181a-2-3p FZD5 0.729676472827631 0.555027073050818 0.0312900090210482 0.972223037324197 MirTarget -0.146446079899034 0.0207850250679641 NA NA NA hsa-miR-23b-3p FZD5 -0.221167036294661 0.878330648681029 0.0312900090210482 0.972223037324197 miRNATAP -0.297747637865034 0.0008797927436913 NA NA NA hsa-miR-24-3p FZD5 0.354839860104953 0.813951308530073 0.0312900090210482 0.972223037324197 miRNAWalker2_validate;miRNATAP -0.263184844031389 0.000902144747885897 NA NA NA hsa-miR-30a-3p FZD5 -1.21767477941485 0.437259873660328 0.0312900090210482 0.972223037324197 mirMAP -0.133705093405462 0.00414882850002822 NA NA NA hsa-miR-342-3p FZD5 0.35619281153521 0.696985677902105 0.0312900090210482 0.972223037324197 PITA -0.102253540270536 0.0303900027274719 NA NA NA hsa-miR-369-3p FZD5 0.658307572343713 0.108939404101946 0.0312900090210482 0.972223037324197 MirTarget;PITA;miRNATAP -0.12209937852773 0.0219709081932499 NA NA NA hsa-miR-374a-5p FZD5 0.280580933704653 0.711312203580958 0.0312900090210482 0.972223037324197 MirTarget -0.252539800538287 0.0161290389743913 NA NA NA hsa-miR-374b-5p FZD5 0.00830204566239612 0.992518773949115 0.0312900090210482 0.972223037324197 MirTarget;miRNATAP -0.170084567054691 0.0301255182253429 NA NA NA hsa-miR-99a-5p FZD5 0.068709821917464 0.952960265191353 0.0312900090210482 0.972223037324197 MirTarget;miRNATAP -0.122313952089455 0.00083365327565079 NA NA NA hsa-miR-101-3p FZD6 0.00372620325665807 0.998376926598058 0.479298932832347 0.481411102006381 miRNAWalker2_validate;MirTarget -0.187151486598272 0.045040886259518 NA NA NA hsa-miR-126-5p FZD6 0.393018523145496 0.713269992183763 0.479298932832347 0.481411102006381 mirMAP;miRNATAP -0.12346112222531 0.0315480031495567 NA NA NA hsa-miR-130a-3p FZD6 0.410890280285832 0.607447245204235 0.479298932832347 0.481411102006381 MirTarget -0.103230972639064 0.0445398169774559 NA NA NA hsa-miR-139-5p FZD6 -1.31022051532559 0.0657735573826271 0.479298932832347 0.481411102006381 miRanda -0.10760466863704 0.0379901970395455 NA NA NA hsa-miR-140-5p FZD6 0.0863677120902411 0.909387194440856 0.479298932832347 0.481411102006381 MirTarget;miRanda -0.226984784166924 6.82889929950221e-05 NA NA NA hsa-miR-194-5p FZD6 1.98051780248547 0.297931251695511 0.479298932832347 0.481411102006381 MirTarget -0.114967495708854 3.82637931799174e-05 NA NA NA hsa-miR-199b-5p FZD6 0.796784137197441 0.425441262968637 0.479298932832347 0.481411102006381 MirTarget;miRanda;miRNATAP -0.121402286920582 0.0264998005792195 NA NA NA hsa-miR-342-3p FZD6 0.35619281153521 0.696985677902105 0.479298932832347 0.481411102006381 miRanda -0.176669812374178 0.000100557168207805 NA NA NA hsa-miR-106b-5p FZD7 0.947523403196215 0.405863421831729 0.123075572228773 0.848528744162883 miRNATAP -0.367840808014823 1.58137319534218e-07 NA NA NA hsa-miR-130b-5p FZD7 1.29600920697695 0.0255462581963971 0.123075572228773 0.848528744162883 mirMAP -0.303590446250517 7.69631395570938e-13 NA NA NA hsa-miR-142-3p FZD7 1.85020414100385 0.249422501446635 0.123075572228773 0.848528744162883 miRanda -0.180391304111435 8.95346838418694e-07 25976503 MicroRNA 142 3p inhibits cell proliferation and invasion of cervical cancer cells by targeting FZD7; In addition we demonstrated that FZD7 was a direct target of miR-142-3p by dual luciferase assay and Western blot analysis; Overexpression of FZD7 expression was able to reverse the inhibitory effects induced by miR-142-3p cervical and endocervical cancer hsa-miR-142-5p FZD7 1.06109968632125 0.257318725443238 0.123075572228773 0.848528744162883 MirTarget;PITA;miRNATAP -0.195273717884424 3.17466310579705e-05 25976503 MicroRNA 142 3p inhibits cell proliferation and invasion of cervical cancer cells by targeting FZD7 cervical and endocervical cancer hsa-miR-186-5p FZD7 0.273626466122302 0.807169118774403 0.123075572228773 0.848528744162883 mirMAP -0.453193540952665 2.99894455851168e-07 NA NA NA hsa-miR-192-5p FZD7 1.83864778676109 0.37609734647626 0.123075572228773 0.848528744162883 miRNAWalker2_validate -0.211278644102795 3.97283811601885e-10 NA NA NA hsa-miR-20a-5p FZD7 1.49559512103718 0.20819591223901 0.123075572228773 0.848528744162883 miRNATAP -0.286699342674646 2.58276381535593e-07 NA NA NA hsa-miR-215-5p FZD7 0.782657078958936 0.568836776061539 0.123075572228773 0.848528744162883 miRNAWalker2_validate -0.12751750415577 3.52562813660825e-06 NA NA NA hsa-miR-27a-3p FZD7 0.505339123854064 0.734502884016765 0.123075572228773 0.848528744162883 MirTarget;miRNATAP -0.497881767504631 4.79576658427489e-07 24018051 Moreover up-regulation of miR-27a did not decrease the FZD7 mRNA level but significantly reduce its protein expression in BEL/5-FU cells; It was also confirmed that reduction of FZD7 by RNA interference induced inhibitory effects on the expression of MDR1/P-glycoprotein and β-catenin similar to miR-27a liver cancer hsa-miR-323a-3p FZD7 0.31643910302896 0.392958762081752 0.123075572228773 0.848528744162883 MirTarget -0.105450786943663 0.0295712919586804 NA NA NA hsa-miR-330-3p FZD7 0.237023779714759 0.466174401969581 0.123075572228773 0.848528744162883 mirMAP -0.305010574210081 5.97419516052652e-06 NA NA NA hsa-miR-335-3p FZD7 2.25543430538924 0.0139006907758541 0.123075572228773 0.848528744162883 mirMAP -0.107946381613777 0.0247434600694844 NA NA NA hsa-miR-338-3p FZD7 -0.0828798547902423 0.951212804477186 0.123075572228773 0.848528744162883 miRanda -0.177867603894644 0.0009307870975513 NA NA NA hsa-miR-338-5p FZD7 -0.469049655008503 0.337730514093722 0.123075572228773 0.848528744162883 MirTarget;PITA;miRNATAP -0.13247416449179 0.0312196078579648 NA NA NA hsa-miR-33a-3p FZD7 -0.0493858782224366 0.86469054162599 0.123075572228773 0.848528744162883 mirMAP;miRNATAP -0.291783587798578 5.58716581329563e-07 NA NA NA hsa-miR-429 FZD7 1.19781217693135 0.322310054579944 0.123075572228773 0.848528744162883 miRanda;miRNATAP -0.272186294355078 1.32797864276533e-16 NA NA NA hsa-miR-486-5p FZD7 -1.48301218922372 0.0956207127449173 0.123075572228773 0.848528744162883 miRanda -0.126212150036754 0.0130494000864524 NA NA NA hsa-miR-532-5p FZD7 1.37200327675848 0.338407542476233 0.123075572228773 0.848528744162883 PITA;miRNATAP -0.238720841531849 0.00043872674495773 NA NA NA hsa-miR-590-3p FZD7 0.750834112502691 0.0721409718537464 0.123075572228773 0.848528744162883 miRanda -0.36936865741074 2.37935673764364e-10 NA NA NA hsa-miR-940 FZD7 1.13111289289361 0.0032414719740783 0.123075572228773 0.848528744162883 miRNAWalker2_validate -0.154259548339835 0.000536689304054142 NA NA NA hsa-miR-324-5p FZD8 0.707588389659175 0.29394916610875 0.306636083677908 0.584057007977703 miRanda -0.130366234463809 0.010505997412534 NA NA NA hsa-miR-335-5p FZD8 0.484676450705085 0.267046535449854 0.306636083677908 0.584057007977703 miRNAWalker2_validate -0.160562374168064 0.00159738246899801 NA NA NA hsa-miR-362-3p FZD8 0.888146502223775 0.0147453056709009 0.306636083677908 0.584057007977703 miRanda -0.230157185311441 8.89130009917968e-06 NA NA NA hsa-miR-429 FZD8 1.19781217693135 0.322310054579944 0.306636083677908 0.584057007977703 miRanda -0.127779103318084 5.84834275931923e-05 NA NA NA hsa-miR-590-3p FZD8 0.750834112502691 0.0721409718537464 0.306636083677908 0.584057007977703 miRanda -0.199274074309407 0.000294604835816665 NA NA NA hsa-miR-7-1-3p FZD8 0.642828512342857 0.399017154673609 0.306636083677908 0.584057007977703 MirTarget -0.184939276431444 0.000331159098519475 NA NA NA hsa-miR-192-5p FZD9 1.83864778676109 0.37609734647626 -1.47637315919259 0.00311651230555616 miRNATAP -0.117926363474423 0.0464066681748434 NA NA NA hsa-miR-101-3p GSK3B 0.00372620325665807 0.998376926598058 0.273161959257147 0.75147548699337 miRNATAP -0.108161751914472 0.01087865904704 NA NA NA hsa-miR-26a-5p GSK3B -0.459645668105514 0.761702789258103 0.273161959257147 0.75147548699337 miRNAWalker2_validate;miRNATAP -0.276398668334029 3.95575891525495e-14 NA NA NA hsa-miR-27b-3p GSK3B -0.493080552908816 0.742657957939545 0.273161959257147 0.75147548699337 miRNATAP -0.110459527996732 0.00277108844798185 NA NA NA hsa-miR-28-5p GSK3B -0.182472063669779 0.853776063784381 0.273161959257147 0.75147548699337 miRanda;miRNATAP -0.126553177913534 0.0124343156692131 NA NA NA hsa-miR-29a-3p GSK3B -0.289266265366038 0.873126628905318 0.273161959257147 0.75147548699337 miRNATAP -0.144457662631292 6.53501471959977e-07 NA NA NA hsa-miR-29c-3p GSK3B -1.25061656348357 0.418526829407785 0.273161959257147 0.75147548699337 miRNATAP -0.155474348899545 3.47249883249066e-12 NA NA NA hsa-miR-30a-3p GSK3B -1.21767477941485 0.437259873660328 0.273161959257147 0.75147548699337 miRNATAP -0.111611289077542 3.43621966685612e-08 NA NA NA hsa-miR-374a-5p GSK3B 0.280580933704653 0.711312203580958 0.273161959257147 0.75147548699337 mirMAP -0.103740072088214 0.0257452070502647 NA NA NA hsa-miR-374b-5p GSK3B 0.00830204566239612 0.992518773949115 0.273161959257147 0.75147548699337 mirMAP -0.171807057871124 4.56335978277982e-07 NA NA NA hsa-miR-127-5p JUN 0.831883513783777 0.426576346713077 -0.933358004202518 0.391398402730481 PITA -0.121319764571159 0.00852545094383945 NA NA NA hsa-miR-141-3p JUN 1.38768814668269 0.324793132237099 -0.933358004202518 0.391398402730481 miRNATAP -0.135407729466269 4.09353208697469e-07 NA NA NA hsa-miR-155-5p JUN 0.689059012865632 0.586621132607867 -0.933358004202518 0.391398402730481 miRNAWalker2_validate;miRTarBase -0.181329105442378 1.35586343503244e-06 23693020 In the present study we demonstrated for the first time that activation of RAGE by S100P regulates oncogenic microRNA-155 miR-155 expression through Activator Protein-1 AP-1 stimulation in colon cancer cells colon cancer hsa-miR-15a-5p JUN 0.999503864534946 0.325292066441584 -0.933358004202518 0.391398402730481 miRNAWalker2_validate -0.372650770700993 8.46426880615505e-12 NA NA NA hsa-miR-16-5p JUN 0.294875982844909 0.811640142720194 -0.933358004202518 0.391398402730481 miRNAWalker2_validate -0.25231147076691 6.33617418839725e-08 NA NA NA hsa-miR-200a-3p JUN 1.70193303671238 0.209370802942576 -0.933358004202518 0.391398402730481 miRNATAP -0.123559771327231 3.2569318830239e-06 NA NA NA hsa-miR-200b-3p JUN 1.76966404687048 0.251078084855527 -0.933358004202518 0.391398402730481 MirTarget;TargetScan -0.127430274428312 1.29168771293238e-05 NA NA NA hsa-miR-200c-3p JUN 1.38059869033872 0.459075461573504 -0.933358004202518 0.391398402730481 MirTarget -0.141043650012032 3.38159827534819e-06 NA NA NA hsa-miR-2355-5p JUN 0.669289715474275 0.346698773665719 -0.933358004202518 0.391398402730481 mirMAP -0.172777405374391 0.00731651512510304 NA NA NA hsa-miR-32-5p JUN 0.32053379451716 0.662616774636995 -0.933358004202518 0.391398402730481 miRNATAP -0.162839387064972 0.00074172329943195 NA NA NA hsa-miR-342-3p JUN 0.35619281153521 0.696985677902105 -0.933358004202518 0.391398402730481 miRNAWalker2_validate -0.137984139739238 0.00223089252850273 NA NA NA hsa-miR-429 JUN 1.19781217693135 0.322310054579944 -0.933358004202518 0.391398402730481 MirTarget;PITA;miRanda;miRNATAP -0.108680908823943 2.00143909179937e-05 NA NA NA hsa-miR-455-3p JUN 0.970088567389584 0.370523301857447 -0.933358004202518 0.391398402730481 miRNATAP -0.103383121706256 0.000254620982311952 NA NA NA hsa-miR-493-5p JUN 1.34217716159816 0.00369808454520068 -0.933358004202518 0.391398402730481 MirTarget;miRNATAP -0.129234954437658 0.0052447346142591 NA NA NA hsa-miR-501-5p JUN 1.51510872844603 0.000249681492153084 -0.933358004202518 0.391398402730481 MirTarget;PITA;miRNATAP -0.163537913781208 1.64939988077063e-05 NA NA NA hsa-miR-542-3p JUN 1.09096556479387 0.289651874996689 -0.933358004202518 0.391398402730481 miRanda -0.232110064103398 0.000143822586534625 NA NA NA hsa-miR-590-3p JUN 0.750834112502691 0.0721409718537464 -0.933358004202518 0.391398402730481 miRanda -0.186132126488839 2.34075777174098e-05 NA NA NA hsa-miR-92a-3p JUN 0.944279015811086 0.614191641461169 -0.933358004202518 0.391398402730481 miRNATAP -0.241738022129755 9.3474499727845e-07 NA NA NA hsa-miR-92b-3p JUN 1.05220938733495 0.263729863193421 -0.933358004202518 0.391398402730481 miRNATAP -0.136201268617777 0.0139342804045594 NA NA NA hsa-miR-93-5p JUN 1.60480485311451 0.351308047161304 -0.933358004202518 0.391398402730481 miRNAWalker2_validate -0.210192122152991 1.52849277002564e-06 NA NA NA hsa-miR-940 JUN 1.13111289289361 0.0032414719740783 -0.933358004202518 0.391398402730481 MirTarget;PITA;miRNATAP -0.104008970923359 0.00162412778014488 NA NA NA hsa-miR-26b-5p LEF1 -0.640970973524183 0.623642285963207 1.57474570136173 0.00748198030017891 miRNATAP -0.193477829030536 0.00345814963545891 24785257 miR26b is downregulated in several cancers and tumors and miR26b directly targets the lymphoid enhancer factor 1 Lef13'UTR and inhibits endogenous Lef1 expression; We report that miR26b expression is associated with human colon cancer through the regulation of LEF1 expression in colon cancer cells; Analyses of multiple colon cancer cell lines revealed an inverse correlation between miR26b and LEF1 expression; Normal human colon cells express low levels of LEF1 and high levels of miR26b; however human colon cancer cells have decreased miR26b expression and increased LEF1 expression; We demonstrate that miR26b expression is a potent inhibitor of colon cancer cell proliferation and significantly decreases LEF1 expression; Analyses of human colon cancer databases also demonstrated a link between miR26b and LEF1 expression colon cancer hsa-miR-502-5p LEF1 0.799178521682916 0.00801502500527688 1.57474570136173 0.00748198030017891 miRNATAP -0.1363255667455 0.0155912979067027 NA NA NA hsa-let-7a-3p LRP6 0.180588894055192 0.807497649839616 0.548486483819687 0.472893174819203 miRNATAP -0.16256940875695 5.41614505609371e-05 NA NA NA hsa-miR-101-5p LRP6 -0.233832762189834 0.545317272240313 0.548486483819687 0.472893174819203 mirMAP -0.149574080757903 0.000273807156247144 NA NA NA hsa-miR-16-5p LRP6 0.294875982844909 0.811640142720194 0.548486483819687 0.472893174819203 miRNATAP -0.110493252843006 0.00185180406854409 NA NA NA hsa-miR-195-5p LRP6 -0.954323940965843 0.175659217190861 0.548486483819687 0.472893174819203 miRNATAP -0.179968417540239 1.14169827386675e-06 NA NA NA hsa-miR-26a-5p LRP6 -0.459645668105514 0.761702789258103 0.548486483819687 0.472893174819203 miRNAWalker2_validate -0.358862640029791 2.78639412300648e-09 NA NA NA hsa-miR-29a-3p LRP6 -0.289266265366038 0.873126628905318 0.548486483819687 0.472893174819203 miRNATAP -0.285208236189688 8.20863567053878e-10 NA NA NA hsa-miR-29b-3p LRP6 -0.0266375641487411 0.98423866564075 0.548486483819687 0.472893174819203 miRNATAP -0.147934454957343 3.35024557518744e-05 NA NA NA hsa-miR-29c-3p LRP6 -1.25061656348357 0.418526829407785 0.548486483819687 0.472893174819203 miRNATAP -0.206749288123275 1.83767122343316e-08 NA NA NA hsa-miR-497-5p LRP6 -0.365153126703569 0.562708968911863 0.548486483819687 0.472893174819203 miRNATAP -0.153465088684621 0.000108648737250264 NA NA NA hsa-miR-590-3p LRP6 0.750834112502691 0.0721409718537464 0.548486483819687 0.472893174819203 PITA;miRanda;miRNATAP -0.118441846728075 0.000336075835538674 NA NA NA hsa-miR-30a-3p MAP3K7 -1.21767477941485 0.437259873660328 0.236935160747729 0.715207137767476 MirTarget -0.116720104885059 2.42022455374327e-08 NA NA NA hsa-miR-30e-3p MAP3K7 -0.528630634076661 0.752496184625955 0.236935160747729 0.715207137767476 MirTarget -0.13274572770718 0.000436366840401447 NA NA NA hsa-miR-374b-5p MAP3K7 0.00830204566239612 0.992518773949115 0.236935160747729 0.715207137767476 mirMAP -0.158972161841343 7.22184945160125e-06 NA NA NA hsa-miR-130b-3p MAPK10 1.118725142912 0.0736094039162448 -1.39256485182482 0.000116634161173785 miRNATAP -0.693545760240947 2.4447567898582e-29 NA NA NA hsa-miR-146b-5p MAPK10 2.36576014745762 0.0657344824311623 -1.39256485182482 0.000116634161173785 miRanda -0.537925599551711 4.57136650006246e-13 NA NA NA hsa-miR-193a-3p MAPK10 0.125692968009939 0.782518392846951 -1.39256485182482 0.000116634161173785 miRanda;miRNATAP -0.360008727779269 0.00154937988666448 NA NA NA hsa-miR-19a-3p MAPK10 1.64946154674522 0.0268746411162676 -1.39256485182482 0.000116634161173785 miRNATAP -0.724337015004809 2.9086422872026e-29 NA NA NA hsa-miR-19b-3p MAPK10 0.806034733762941 0.431963517845538 -1.39256485182482 0.000116634161173785 miRNATAP -0.84885378816188 8.29966292733463e-26 NA NA NA hsa-miR-221-3p MAPK10 1.07685645039261 0.364046062901123 -1.39256485182482 0.000116634161173785 miRNATAP -0.939796891067402 5.39881369095105e-32 NA NA NA hsa-miR-222-3p MAPK10 1.39835693864931 0.143802388795275 -1.39256485182482 0.000116634161173785 miRNATAP -0.839068830411475 1.15885462144123e-39 NA NA NA hsa-miR-29a-3p MAPK10 -0.289266265366038 0.873126628905318 -1.39256485182482 0.000116634161173785 miRNATAP -0.360393193075163 0.0029115140889112 NA NA NA hsa-miR-29b-3p MAPK10 -0.0266375641487411 0.98423866564075 -1.39256485182482 0.000116634161173785 miRNATAP -0.592235509952437 1.8296935691195e-11 24767251 The percentage of positive myeloid cell leukemia sequence 1 ATG9A and MAPK10 protein expression and low miR-29b mRNA expression were significantly higher in cases with clinical stage III and IV ovarian cancer than in cases with clinical stage II ovarian cancer; Univariate Kaplan-Meier analysis showed a negative correlation between MAPK10 or ATG9A protein expression and overall as well as progression-free survival whereas a positive correlation was observed between miR-29b mRNA expression and overall as well as progression-free survival; Multivariate Cox regression analysis showed that elevated MAPK10 or ATG9A protein and lowered miR-29b mRNA expression in ovarian carcinoma was an independent poor prognostic predictor; Our study suggested that miR-29b mRNA MAPK10 protein expression and ATG9A protein expression are closely related to chemosensitivity of ovarian carcinoma staging;progression;poor survival ovarian cancer hsa-miR-301a-3p MAPK10 1.18000372861766 0.00831128124191879 -1.39256485182482 0.000116634161173785 miRNATAP -0.73116908399916 6.67687308243316e-19 NA NA NA hsa-miR-30d-3p MAPK10 -0.0804985653060761 0.825203889451817 -1.39256485182482 0.000116634161173785 mirMAP -0.649392662024409 2.09177108125924e-08 NA NA NA hsa-miR-330-3p MAPK10 0.237023779714759 0.466174401969581 -1.39256485182482 0.000116634161173785 PITA;miRNATAP -0.51679544304703 3.24739883194547e-08 NA NA NA hsa-miR-429 MAPK10 1.19781217693135 0.322310054579944 -1.39256485182482 0.000116634161173785 miRNATAP -0.477341185239786 2.92338603507131e-27 NA NA NA hsa-miR-450b-5p MAPK10 1.31989436603254 0.00773738577557236 -1.39256485182482 0.000116634161173785 mirMAP -0.498342393122139 6.22817373122146e-09 NA NA NA hsa-miR-454-3p MAPK10 0.737467730442439 0.0944172375936656 -1.39256485182482 0.000116634161173785 miRNATAP -0.733043181621775 1.13299248267906e-14 NA NA NA hsa-miR-455-5p MAPK10 0.610591180666197 0.405984831720842 -1.39256485182482 0.000116634161173785 miRanda -0.650767223536279 1.16447923173394e-14 NA NA NA hsa-miR-582-5p MAPK10 -0.0750818699965312 0.895875799292592 -1.39256485182482 0.000116634161173785 PITA -0.410323594071672 6.65261734264751e-06 NA NA NA hsa-miR-590-3p MAPK10 0.750834112502691 0.0721409718537464 -1.39256485182482 0.000116634161173785 miRanda;mirMAP -0.773270404263229 1.58682108350245e-23 NA NA NA hsa-miR-590-5p MAPK10 0.763126350124264 0.184296330120049 -1.39256485182482 0.000116634161173785 PITA;miRanda;miRNATAP -0.695585370154259 3.81369874978754e-21 NA NA NA hsa-miR-935 MAPK10 2.18097631134671 4.12025538006203e-05 -1.39256485182482 0.000116634161173785 miRNATAP -0.39239427580067 3.78935582148855e-21 NA NA NA hsa-miR-940 MAPK10 1.13111289289361 0.0032414719740783 -1.39256485182482 0.000116634161173785 PITA;miRNATAP -0.427511572432241 1.26206970769644e-12 NA NA NA hsa-miR-125a-5p MAPK8 -0.134418454752295 0.908401725750299 0.0854812401210747 0.861386581391528 miRNAWalker2_validate -0.172254570825685 1.32226769293905e-05 NA NA NA hsa-miR-130a-3p MAPK8 0.410890280285832 0.607447245204235 0.0854812401210747 0.861386581391528 mirMAP -0.183819342868255 1.55987166215855e-08 NA NA NA hsa-miR-195-3p MAPK8 -0.522236286339218 0.0566853778570702 0.0854812401210747 0.861386581391528 mirMAP -0.133812769458224 0.000121231997329912 NA NA NA hsa-miR-214-3p MAPK8 1.17438168945275 0.00800639797957431 0.0854812401210747 0.861386581391528 miRNAWalker2_validate -0.167159296353041 2.02611534521065e-09 19859982 HeLa cells that stably overexpress miR-214 downregulate the expression of MEK3 and JNK1 at both mRNA and protein levels; Further investigation revealed that miR-214 regulates the expression of MEK3 and JNK1 by targeting the 3'UTRs of these genes; Collectively these results suggest that miR-214 negatively regulates HeLa cell proliferation by targeting the noncoding regions of MEK3 and JNK1 mRNAs cervical and endocervical cancer hsa-miR-22-5p MAPK8 0.563707897845906 0.429790318970966 0.0854812401210747 0.861386581391528 mirMAP -0.118190801730899 0.000228819278308324 NA NA NA hsa-miR-30a-5p MAPK8 -0.622409301903435 0.733062880166898 0.0854812401210747 0.861386581391528 mirMAP -0.149356052916285 3.34316710822252e-05 NA NA NA hsa-miR-30b-5p MAPK8 -0.124247247359659 0.917685196303453 0.0854812401210747 0.861386581391528 mirMAP -0.146570484740126 2.54398482951371e-05 NA NA NA hsa-miR-30c-5p MAPK8 -0.208331154216021 0.863518338736092 0.0854812401210747 0.861386581391528 mirMAP -0.185745101418266 8.0455605200807e-06 NA NA NA hsa-miR-374a-3p MAPK8 0.00444091189256923 0.997279477304268 0.0854812401210747 0.861386581391528 mirMAP -0.123622145164846 0.0131996005094652 NA NA NA hsa-miR-126-5p MAPK9 0.393018523145496 0.713269992183763 -0.0643875854907154 0.931665422749571 mirMAP -0.127831059953846 2.24339338339211e-05 NA NA NA hsa-miR-361-5p MAPK9 0.517068298358111 0.640548482802509 -0.0643875854907154 0.931665422749571 miRanda -0.105446131615564 0.0484557379514954 NA NA NA hsa-miR-374a-5p MAPK9 0.280580933704653 0.711312203580958 -0.0643875854907154 0.931665422749571 mirMAP -0.157616078246699 0.0035636339195342 NA NA NA hsa-miR-129-5p MMP7 -1.43651546966112 0.00183085217431586 3.71354923080305 2.63980178983943e-05 miRanda -0.374126783620347 0.000451406876446808 NA NA NA hsa-let-7c-5p MYC 0.194692337809501 0.890544517884071 -0.000391152150100105 0.999676977060757 miRNAWalker2_validate;miRTarBase -0.117429030238432 0.00982219946674066 22128178 MicroRNA let 7c suppresses androgen receptor expression and activity via regulation of Myc expression in prostate cancer cells prostate cancer hsa-miR-26a-5p MYC -0.459645668105514 0.761702789258103 -0.000391152150100105 0.999676977060757 miRNAWalker2_validate -0.282916794526639 0.00222606342624675 21901171 Our results identify new molecular targets of c-Myc in AML and highlight miR-26a attractiveness as a therapeutic target in leukemia acute myeloid leukemia hsa-miR-34c-5p MYC 1.52472702454739 1.53759503188217e-07 -0.000391152150100105 0.999676977060757 miRNAWalker2_validate;miRTarBase;miRanda -0.161936986237348 0.000782914009115942 NA NA NA hsa-let-7a-3p NFAT5 0.180588894055192 0.807497649839616 0.546887268503879 0.548227364552505 MirTarget;mirMAP;miRNATAP -0.296088889439994 1.01735582477778e-11 NA NA NA hsa-let-7b-3p NFAT5 0.273132474559554 0.682533246372485 0.546887268503879 0.548227364552505 MirTarget;mirMAP;miRNATAP -0.260837194163969 1.60255294467283e-05 NA NA NA hsa-let-7f-1-3p NFAT5 1.02975898416111 0.00216616040865014 0.546887268503879 0.548227364552505 MirTarget;mirMAP -0.103149955276787 0.0266869324737741 NA NA NA hsa-miR-101-5p NFAT5 -0.233832762189834 0.545317272240313 0.546887268503879 0.548227364552505 MirTarget -0.134739421638889 0.00331569051503864 NA NA NA hsa-miR-106b-5p NFAT5 0.947523403196215 0.405863421831729 0.546887268503879 0.548227364552505 MirTarget;miRNATAP -0.152484588452561 0.000481049702118708 NA NA NA hsa-miR-10b-5p NFAT5 -0.349066414045252 0.854598143201285 0.546887268503879 0.548227364552505 MirTarget;miRNATAP -0.224155965375566 3.79795549960164e-06 NA NA NA hsa-miR-126-5p NFAT5 0.393018523145496 0.713269992183763 0.546887268503879 0.548227364552505 MirTarget;mirMAP -0.2575044284791 2.05824424457948e-08 NA NA NA hsa-miR-130b-5p NFAT5 1.29600920697695 0.0255462581963971 0.546887268503879 0.548227364552505 MirTarget;miRNATAP -0.141307984240233 1.03368853109193e-07 NA NA NA hsa-miR-140-5p NFAT5 0.0863677120902411 0.909387194440856 0.546887268503879 0.548227364552505 PITA;miRNATAP -0.293196587861517 1.34811800320502e-10 NA NA NA hsa-miR-141-3p NFAT5 1.38768814668269 0.324793132237099 0.546887268503879 0.548227364552505 mirMAP -0.101487722423398 5.33364124008141e-06 NA NA NA hsa-miR-142-5p NFAT5 1.06109968632125 0.257318725443238 0.546887268503879 0.548227364552505 MirTarget;PITA;miRNATAP -0.144609587303139 4.18732959148088e-07 NA NA NA hsa-miR-144-5p NFAT5 -1.31041623056934 0.122751386505603 0.546887268503879 0.548227364552505 mirMAP -0.118411662475103 7.11672220065169e-05 NA NA NA hsa-miR-146a-5p NFAT5 0.67061946633831 0.538820409992621 0.546887268503879 0.548227364552505 mirMAP;miRNATAP -0.124890117889391 2.05060834460075e-05 NA NA NA hsa-miR-148a-3p NFAT5 -0.336734438265406 0.874732520340819 0.546887268503879 0.548227364552505 miRNATAP -0.20029502984724 4.19505967269105e-11 NA NA NA hsa-miR-148a-5p NFAT5 -0.0671657147202627 0.935632562211656 0.546887268503879 0.548227364552505 mirMAP -0.174905846372666 4.72876045609588e-08 NA NA NA hsa-miR-148b-3p NFAT5 0.686272171036606 0.498004854065858 0.546887268503879 0.548227364552505 miRNATAP -0.208113379768311 9.84939924089083e-06 NA NA NA hsa-miR-148b-5p NFAT5 0.572058810509307 0.0857637180513597 0.546887268503879 0.548227364552505 MirTarget -0.130880252080734 4.42115274546614e-05 NA NA NA hsa-miR-154-5p NFAT5 0.137785130821394 0.696984789390429 0.546887268503879 0.548227364552505 mirMAP -0.166425647098258 1.24843198623287e-05 NA NA NA hsa-miR-155-5p NFAT5 0.689059012865632 0.586621132607867 0.546887268503879 0.548227364552505 mirMAP;miRNATAP -0.177372730636563 9.22614852468153e-09 NA NA NA hsa-miR-15b-3p NFAT5 0.616287210571229 0.422509520506848 0.546887268503879 0.548227364552505 mirMAP -0.212536376536875 7.73050475300888e-11 NA NA NA hsa-miR-15b-5p NFAT5 0.441873888832829 0.683456288766732 0.546887268503879 0.548227364552505 MirTarget -0.234567019496252 9.37173445170646e-08 NA NA NA hsa-miR-16-5p NFAT5 0.294875982844909 0.811640142720194 0.546887268503879 0.548227364552505 MirTarget -0.271054050062119 9.17697579506393e-13 NA NA NA hsa-miR-186-5p NFAT5 0.273626466122302 0.807169118774403 0.546887268503879 0.548227364552505 MirTarget;mirMAP -0.24425645843505 7.6872625421484e-06 NA NA NA hsa-miR-192-3p NFAT5 1.53303749871781 0.126158902379712 0.546887268503879 0.548227364552505 MirTarget;miRNATAP -0.137610204734376 1.93867235881819e-11 NA NA NA hsa-miR-194-3p NFAT5 1.69586201919604 0.103388813689903 0.546887268503879 0.548227364552505 miRNATAP -0.102331026773939 4.30492788765221e-06 NA NA NA hsa-miR-194-5p NFAT5 1.98051780248547 0.297931251695511 0.546887268503879 0.548227364552505 miRNATAP -0.102068053263999 7.83952544867365e-06 NA NA NA hsa-miR-195-5p NFAT5 -0.954323940965843 0.175659217190861 0.546887268503879 0.548227364552505 MirTarget -0.206280117576242 5.01384274047306e-07 NA NA NA hsa-miR-20a-3p NFAT5 0.44568974632412 0.380391798091882 0.546887268503879 0.548227364552505 MirTarget;miRNATAP -0.126628595485631 4.04466204723879e-06 NA NA NA hsa-miR-21-3p NFAT5 1.74562165194276 0.287275799258641 0.546887268503879 0.548227364552505 MirTarget -0.104270818314404 0.00268214487739577 NA NA NA hsa-miR-212-3p NFAT5 0.895869490569324 0.0316777138361649 0.546887268503879 0.548227364552505 miRNATAP -0.163875345127587 0.000651348619347028 NA NA NA hsa-miR-2355-3p NFAT5 0.0922515944773004 0.789430438736429 0.546887268503879 0.548227364552505 MirTarget;miRNATAP -0.175800524686379 1.09616267080927e-07 NA NA NA hsa-miR-24-3p NFAT5 0.354839860104953 0.813951308530073 0.546887268503879 0.548227364552505 miRNAWalker2_validate;miRNATAP -0.222213819949555 0.000427771675549964 NA NA NA hsa-miR-26b-3p NFAT5 0.189972507055099 0.7740623413589 0.546887268503879 0.548227364552505 MirTarget;miRNATAP -0.149250367820116 9.72499548734624e-07 NA NA NA hsa-miR-27a-3p NFAT5 0.505339123854064 0.734502884016765 0.546887268503879 0.548227364552505 MirTarget -0.179154685883858 0.00366802057392652 NA NA NA hsa-miR-27b-3p NFAT5 -0.493080552908816 0.742657957939545 0.546887268503879 0.548227364552505 MirTarget -0.173815681422228 0.00900819700254291 NA NA NA hsa-miR-29a-3p NFAT5 -0.289266265366038 0.873126628905318 0.546887268503879 0.548227364552505 MirTarget;miRNATAP -0.288424557425303 2.81729868773212e-08 NA NA NA hsa-miR-29b-3p NFAT5 -0.0266375641487411 0.98423866564075 0.546887268503879 0.548227364552505 MirTarget;miRNATAP -0.184388982200114 2.96896500405868e-06 NA NA NA hsa-miR-29c-3p NFAT5 -1.25061656348357 0.418526829407785 0.546887268503879 0.548227364552505 MirTarget;miRNATAP -0.225458436686572 3.49037436660913e-08 NA NA NA hsa-miR-30b-5p NFAT5 -0.124247247359659 0.917685196303453 0.546887268503879 0.548227364552505 MirTarget;miRNATAP -0.203465041454407 3.39772860868941e-06 NA NA NA hsa-miR-30c-5p NFAT5 -0.208331154216021 0.863518338736092 0.546887268503879 0.548227364552505 MirTarget;miRNATAP -0.11653760519373 0.0288087438494293 NA NA NA hsa-miR-30e-5p NFAT5 -0.318933868943279 0.850982406429589 0.546887268503879 0.548227364552505 MirTarget;miRNATAP -0.287314563471604 1.62338354960969e-06 NA NA NA hsa-miR-32-5p NFAT5 0.32053379451716 0.662616774636995 0.546887268503879 0.548227364552505 miRNATAP -0.2230865878966 1.36720376465094e-08 NA NA NA hsa-miR-320a NFAT5 0.22287875340213 0.865731646872282 0.546887268503879 0.548227364552505 mirMAP -0.173525816298917 0.000314372413115937 NA NA NA hsa-miR-320b NFAT5 0.941267876385794 0.0453505938355543 0.546887268503879 0.548227364552505 mirMAP -0.144441020547587 1.01741436335605e-05 NA NA NA hsa-miR-324-5p NFAT5 0.707588389659175 0.29394916610875 0.546887268503879 0.548227364552505 MirTarget;PITA;miRNATAP -0.129399641544315 0.000123403414974977 NA NA NA hsa-miR-330-3p NFAT5 0.237023779714759 0.466174401969581 0.546887268503879 0.548227364552505 mirMAP -0.177716698301342 1.78503309931346e-05 NA NA NA hsa-miR-335-5p NFAT5 0.484676450705085 0.267046535449854 0.546887268503879 0.548227364552505 miRNAWalker2_validate -0.126982358671528 0.00017047524591173 NA NA NA hsa-miR-337-3p NFAT5 -0.200974746298455 0.76060131904003 0.546887268503879 0.548227364552505 PITA;mirMAP -0.181496087955512 1.00566359248691e-06 NA NA NA hsa-miR-338-5p NFAT5 -0.469049655008503 0.337730514093722 0.546887268503879 0.548227364552505 MirTarget;PITA;mirMAP -0.106823896431256 0.00451051106251162 NA NA NA hsa-miR-33a-3p NFAT5 -0.0493858782224366 0.86469054162599 0.546887268503879 0.548227364552505 mirMAP -0.21206020638004 2.1277434636677e-09 NA NA NA hsa-miR-33a-5p NFAT5 0.179538686749402 0.795042829975416 0.546887268503879 0.548227364552505 MirTarget -0.106802273268025 4.32338640351689e-07 NA NA NA hsa-miR-3607-3p NFAT5 0.402426470225138 0.613303667114625 0.546887268503879 0.548227364552505 mirMAP;miRNATAP -0.106285383289404 1.18484603799165e-07 NA NA NA hsa-miR-3613-5p NFAT5 0.888536545073334 0.0940415939776757 0.546887268503879 0.548227364552505 miRNATAP -0.170438364511413 1.82764368561792e-07 NA NA NA hsa-miR-3653-3p NFAT5 0.633424200635214 0.120436672464276 0.546887268503879 0.548227364552505 MirTarget -0.157861806623428 1.32779946526231e-09 NA NA NA hsa-miR-365a-3p NFAT5 -0.790131900517861 0.243880854457027 0.546887268503879 0.548227364552505 MirTarget -0.156013438239883 0.00169000102797048 NA NA NA hsa-miR-374a-3p NFAT5 0.00444091189256923 0.997279477304268 0.546887268503879 0.548227364552505 mirMAP -0.208860368771986 0.000865320046751688 NA NA NA hsa-miR-374b-5p NFAT5 0.00830204566239612 0.992518773949115 0.546887268503879 0.548227364552505 mirMAP;miRNATAP -0.174421679447915 0.00511972938829084 NA NA NA hsa-miR-376c-3p NFAT5 -0.167535459159723 0.680458122572437 0.546887268503879 0.548227364552505 MirTarget -0.145724942620143 3.49035275554012e-05 NA NA NA hsa-miR-411-5p NFAT5 -0.271202077256236 0.529208646371761 0.546887268503879 0.548227364552505 mirMAP -0.162589684763955 0.000248598803065506 NA NA NA hsa-miR-424-3p NFAT5 1.10789213694712 0.000555346633041339 0.546887268503879 0.548227364552505 miRNATAP -0.121470819375232 0.000244378364892281 NA NA NA hsa-miR-424-5p NFAT5 0.778229637040266 0.39502076082444 0.546887268503879 0.548227364552505 MirTarget -0.217891270326561 1.47990733739615e-13 NA NA NA hsa-miR-429 NFAT5 1.19781217693135 0.322310054579944 0.546887268503879 0.548227364552505 miRNATAP -0.111992840145711 9.01547234226917e-08 NA NA NA hsa-miR-486-5p NFAT5 -1.48301218922372 0.0956207127449173 0.546887268503879 0.548227364552505 PITA;miRNATAP -0.135898258946994 1.02961417978826e-05 NA NA NA hsa-miR-495-3p NFAT5 -0.0502636491763475 0.910413613991017 0.546887268503879 0.548227364552505 MirTarget;mirMAP -0.162693049398891 0.000170359770122802 NA NA NA hsa-miR-497-5p NFAT5 -0.365153126703569 0.562708968911863 0.546887268503879 0.548227364552505 MirTarget -0.186199718801693 2.25963223162176e-05 NA NA NA hsa-miR-511-5p NFAT5 0.743122530026616 0.141222906192463 0.546887268503879 0.548227364552505 MirTarget -0.125438954963061 0.000108748389941984 NA NA NA hsa-miR-576-5p NFAT5 0.744407899578399 0.146981973135162 0.546887268503879 0.548227364552505 MirTarget;PITA;mirMAP -0.102442161735055 0.0073749620821899 NA NA NA hsa-miR-582-3p NFAT5 -0.288909714315645 0.798328823284484 0.546887268503879 0.548227364552505 MirTarget -0.160210582398433 1.47173374652335e-05 NA NA NA hsa-miR-582-5p NFAT5 -0.0750818699965312 0.895875799292592 0.546887268503879 0.548227364552505 MirTarget;PITA;miRNATAP -0.134076518619075 0.000864924318143589 NA NA NA hsa-miR-590-3p NFAT5 0.750834112502691 0.0721409718537464 0.546887268503879 0.548227364552505 MirTarget;miRanda;mirMAP;miRNATAP -0.181456870763153 5.72781754008267e-07 NA NA NA hsa-miR-590-5p NFAT5 0.763126350124264 0.184296330120049 0.546887268503879 0.548227364552505 PITA;mirMAP;miRNATAP -0.123221158132646 0.000375085535291448 NA NA NA hsa-miR-652-3p NFAT5 1.06412954717453 0.144893508353574 0.546887268503879 0.548227364552505 miRNAWalker2_validate -0.13945472114376 0.000342725471604798 NA NA NA hsa-miR-654-3p NFAT5 -0.159408393093276 0.803524098022073 0.546887268503879 0.548227364552505 mirMAP -0.198662777605705 1.30311479159459e-08 NA NA NA hsa-miR-664a-5p NFAT5 -0.245538311240215 0.360416705748091 0.546887268503879 0.548227364552505 mirMAP -0.179540696886038 4.79505010377402e-06 NA NA NA hsa-miR-7-1-3p NFAT5 0.642828512342857 0.399017154673609 0.546887268503879 0.548227364552505 mirMAP -0.150782023971998 9.98573886893856e-06 NA NA NA hsa-miR-940 NFAT5 1.13111289289361 0.0032414719740783 0.546887268503879 0.548227364552505 MirTarget -0.141034049200526 1.66913326499244e-07 NA NA NA hsa-miR-3127-5p NFATC1 1.07283726006422 0.00620209739135467 0.21673059464479 0.714591431511735 MirTarget -0.224233279000793 1.88367382560328e-06 NA NA NA hsa-miR-421 NFATC1 1.28183445098144 3.9841687793795e-06 0.21673059464479 0.714591431511735 miRanda -0.167153499054643 0.00133042051298546 NA NA NA hsa-miR-455-5p NFATC1 0.610591180666197 0.405984831720842 0.21673059464479 0.714591431511735 miRanda -0.211299987793271 0.000143351006745795 NA NA NA hsa-miR-940 NFATC1 1.13111289289361 0.0032414719740783 0.21673059464479 0.714591431511735 PITA -0.120273049336217 0.00236539660028171 NA NA NA hsa-miR-130b-5p NFATC4 1.29600920697695 0.0255462581963971 -0.328333671165882 0.527070050308326 mirMAP -0.410803925444607 4.93078883792223e-24 NA NA NA hsa-miR-150-5p NFATC4 0.481167647702842 0.709626991980819 -0.328333671165882 0.527070050308326 mirMAP -0.101089999661587 0.0362179276846314 NA NA NA hsa-miR-15b-3p NFATC4 0.616287210571229 0.422509520506848 -0.328333671165882 0.527070050308326 mirMAP -0.528561190398866 7.22979437052853e-26 NA NA NA hsa-miR-181a-5p NFATC4 1.4443526859599 0.296372990368445 -0.328333671165882 0.527070050308326 mirMAP -0.416007277272078 4.69687975411974e-08 NA NA NA hsa-miR-181b-5p NFATC4 1.46153693463023 0.179461012757425 -0.328333671165882 0.527070050308326 mirMAP -0.36107116343545 1.60269939145714e-07 NA NA NA hsa-miR-185-3p NFATC4 1.29970093498066 0.00088003078050264 -0.328333671165882 0.527070050308326 MirTarget -0.436649183849917 1.36683277057914e-13 NA NA NA hsa-miR-29a-3p NFATC4 -0.289266265366038 0.873126628905318 -0.328333671165882 0.527070050308326 miRNATAP -0.402689133600023 2.62869768330642e-06 NA NA NA hsa-miR-29b-3p NFATC4 -0.0266375641487411 0.98423866564075 -0.328333671165882 0.527070050308326 miRNATAP -0.466368106592573 9.25199858359518e-14 NA NA NA hsa-miR-320b NFATC4 0.941267876385794 0.0453505938355543 -0.328333671165882 0.527070050308326 miRanda;mirMAP -0.284797260252016 8.16053943716232e-08 NA NA NA hsa-miR-3607-3p NFATC4 0.402426470225138 0.613303667114625 -0.328333671165882 0.527070050308326 miRNATAP -0.13135227579544 7.73345002848596e-05 NA NA NA hsa-miR-361-3p NFATC4 0.480275847363033 0.635924490895616 -0.328333671165882 0.527070050308326 mirMAP -0.702481393283074 1.06100565999118e-14 NA NA NA hsa-miR-423-5p NFATC4 0.535276881480568 0.51312358537587 -0.328333671165882 0.527070050308326 miRNATAP -0.365508224968976 0.000163561809128467 NA NA NA hsa-miR-429 NFATC4 1.19781217693135 0.322310054579944 -0.328333671165882 0.527070050308326 miRNATAP -0.322916557199747 7.95180935815265e-24 NA NA NA hsa-miR-484 NFATC4 0.340101271888636 0.69389289011036 -0.328333671165882 0.527070050308326 MirTarget;miRNATAP -0.455756721636553 1.38976155755543e-12 NA NA NA hsa-miR-532-5p NFATC4 1.37200327675848 0.338407542476233 -0.328333671165882 0.527070050308326 mirMAP -0.612170223040864 3.90980470548469e-22 NA NA NA hsa-miR-625-5p NFATC4 0.51369754623655 0.274843890626581 -0.328333671165882 0.527070050308326 mirMAP -0.434214555816272 7.7635480579765e-22 NA NA NA hsa-miR-629-3p NFATC4 0.551260052178687 0.20899418574898 -0.328333671165882 0.527070050308326 mirMAP -0.361828031608133 1.14515038265004e-15 NA NA NA hsa-miR-940 NFATC4 1.13111289289361 0.0032414719740783 -0.328333671165882 0.527070050308326 miRNATAP -0.215845795697506 1.07800652005694e-06 NA NA NA hsa-miR-140-5p NKD1 0.0863677120902411 0.909387194440856 -0.407180963031045 0.476656835414301 miRanda -0.570129990358568 5.53870792366756e-05 NA NA NA hsa-miR-188-5p NKD1 1.39119308895556 0.000791755580412654 -0.407180963031045 0.476656835414301 PITA;miRNATAP -0.287158914065619 0.00157684444872393 NA NA NA hsa-miR-200b-3p NKD1 1.76966404687048 0.251078084855527 -0.407180963031045 0.476656835414301 TargetScan -0.302543989129346 3.88399922641002e-05 NA NA NA hsa-miR-21-5p NKD1 2.24244475408756 0.372600191183534 -0.407180963031045 0.476656835414301 mirMAP -0.519886059435425 0.000185654099592008 NA NA NA hsa-miR-326 NKD1 -0.686277598234758 0.130157755184283 -0.407180963031045 0.476656835414301 miRanda -0.299475654155649 0.00138297234493815 NA NA NA hsa-miR-330-5p NKD1 0.522359698833297 0.46945472961169 -0.407180963031045 0.476656835414301 miRanda;miRNATAP -0.67416630282949 2.13600494197995e-08 NA NA NA hsa-miR-369-3p NKD1 0.658307572343713 0.108939404101946 -0.407180963031045 0.476656835414301 PITA;miRNATAP -0.312152236018059 0.0150567234020912 NA NA NA hsa-miR-429 NKD1 1.19781217693135 0.322310054579944 -0.407180963031045 0.476656835414301 miRanda;miRNATAP -0.252507896145131 8.33276333078049e-05 NA NA NA hsa-miR-455-3p NKD1 0.970088567389584 0.370523301857447 -0.407180963031045 0.476656835414301 miRNATAP -0.195730096072928 0.00611588870495265 NA NA NA hsa-miR-501-5p NKD1 1.51510872844603 0.000249681492153084 -0.407180963031045 0.476656835414301 mirMAP -0.327432908830409 0.000646644585544084 NA NA NA hsa-miR-532-5p NKD1 1.37200327675848 0.338407542476233 -0.407180963031045 0.476656835414301 PITA;miRNATAP -0.342161840675215 0.00691495667219333 NA NA NA hsa-miR-139-5p NLK -1.31022051532559 0.0657735573826271 0.420376552438263 0.469145315412108 miRanda -0.100243167327005 0.000216505685155652 NA NA NA hsa-miR-152-3p NLK -0.0155559280739608 0.988199850270767 0.420376552438263 0.469145315412108 MirTarget -0.126840334580691 0.00301448529276371 NA NA NA hsa-miR-28-5p NLK -0.182472063669779 0.853776063784381 0.420376552438263 0.469145315412108 miRanda -0.222680735165269 0.000126162206216784 NA NA NA hsa-let-7g-3p PLCB1 0.692324017258497 0.345964739358737 0.240859081180217 0.70209283187101 miRNATAP -0.296454903501695 1.54706325389887e-10 NA NA NA hsa-miR-106b-5p PLCB1 0.947523403196215 0.405863421831729 0.240859081180217 0.70209283187101 miRNATAP -0.305855408737131 8.08459339047932e-05 NA NA NA hsa-miR-107 PLCB1 0.808649908398562 0.357609254490153 0.240859081180217 0.70209283187101 PITA;miRanda;miRNATAP -0.385465115728602 0.0008397907192367 NA NA NA hsa-miR-130b-3p PLCB1 1.118725142912 0.0736094039162448 0.240859081180217 0.70209283187101 miRNATAP -0.270329731553997 2.93431478757673e-07 NA NA NA hsa-miR-142-3p PLCB1 1.85020414100385 0.249422501446635 0.240859081180217 0.70209283187101 PITA;miRanda;miRNATAP -0.284724445687842 3.22076762696382e-13 NA NA NA hsa-miR-16-2-3p PLCB1 0.73180598347188 0.153070057533699 0.240859081180217 0.70209283187101 mirMAP -0.379471765688322 4.12792502511737e-12 NA NA NA hsa-miR-17-5p PLCB1 1.42323729519248 0.26500282246461 0.240859081180217 0.70209283187101 TargetScan;miRNATAP -0.231665700742235 9.42738851341771e-05 NA NA NA hsa-miR-199a-3p PLCB1 1.20746327187529 0.434443647645962 0.240859081180217 0.70209283187101 PITA -0.241298993856276 0.008939633994082 NA NA NA hsa-miR-199b-3p PLCB1 1.20816960143913 0.434036915050342 0.240859081180217 0.70209283187101 PITA;miRNATAP -0.242174002846781 0.00862186171874026 NA NA NA hsa-miR-19a-3p PLCB1 1.64946154674522 0.0268746411162676 0.240859081180217 0.70209283187101 miRNATAP -0.199615128098506 0.000349201194676956 NA NA NA hsa-miR-19b-3p PLCB1 0.806034733762941 0.431963517845538 0.240859081180217 0.70209283187101 miRNATAP -0.293735244517352 1.8627267103244e-05 NA NA NA hsa-miR-20a-5p PLCB1 1.49559512103718 0.20819591223901 0.240859081180217 0.70209283187101 miRNATAP -0.128472881332162 0.0387243519959691 NA NA NA hsa-miR-26a-2-3p PLCB1 0.0416400673740434 0.887900422135032 0.240859081180217 0.70209283187101 mirMAP -0.261438639445837 0.000320583512349883 NA NA NA hsa-miR-26a-5p PLCB1 -0.459645668105514 0.761702789258103 0.240859081180217 0.70209283187101 miRNATAP -0.379638523180342 0.00194011533953377 NA NA NA hsa-miR-26b-5p PLCB1 -0.640970973524183 0.623642285963207 0.240859081180217 0.70209283187101 miRNATAP -0.366782088318907 6.40980035962043e-07 NA NA NA hsa-miR-299-5p PLCB1 -0.148616858222387 0.624393570977462 0.240859081180217 0.70209283187101 PITA -0.29239643184685 4.52660861103404e-05 NA NA NA hsa-miR-301a-3p PLCB1 1.18000372861766 0.00831128124191879 0.240859081180217 0.70209283187101 miRNATAP -0.290632461939252 1.90430531126337e-05 NA NA NA hsa-miR-320b PLCB1 0.941267876385794 0.0453505938355543 0.240859081180217 0.70209283187101 miRanda -0.205263254758424 0.000473283203094198 NA NA NA hsa-miR-330-3p PLCB1 0.237023779714759 0.466174401969581 0.240859081180217 0.70209283187101 PITA;mirMAP -0.366356792782592 5.93268145296171e-07 NA NA NA hsa-miR-335-3p PLCB1 2.25543430538924 0.0139006907758541 0.240859081180217 0.70209283187101 mirMAP -0.155081868023876 0.00307347986853507 NA NA NA hsa-miR-338-5p PLCB1 -0.469049655008503 0.337730514093722 0.240859081180217 0.70209283187101 PITA;mirMAP;miRNATAP -0.26215454801719 8.19264690354463e-05 NA NA NA hsa-miR-34a-5p PLCB1 0.563661494017221 0.590317849063448 0.240859081180217 0.70209283187101 miRNATAP -0.493909689465719 1.24164120020151e-12 NA NA NA hsa-miR-369-3p PLCB1 0.658307572343713 0.108939404101946 0.240859081180217 0.70209283187101 mirMAP -0.319753969650615 1.88653835671283e-05 NA NA NA hsa-miR-423-5p PLCB1 0.535276881480568 0.51312358537587 0.240859081180217 0.70209283187101 miRNAWalker2_validate;PITA;miRNATAP -0.273190100562846 0.0102001670389705 NA NA NA hsa-miR-429 PLCB1 1.19781217693135 0.322310054579944 0.240859081180217 0.70209283187101 miRNATAP -0.181100259193934 1.38822413920582e-06 NA NA NA hsa-miR-454-3p PLCB1 0.737467730442439 0.0944172375936656 0.240859081180217 0.70209283187101 miRNATAP -0.332659097665776 1.54445654306026e-05 NA NA NA hsa-miR-485-3p PLCB1 0.967037740891141 0.00391462029256323 0.240859081180217 0.70209283187101 PITA;mirMAP -0.188638828303415 0.00460973531529237 NA NA NA hsa-miR-577 PLCB1 0.356857462342957 0.638858200569284 0.240859081180217 0.70209283187101 PITA;mirMAP;miRNATAP -0.135914566226532 2.94148471736011e-05 NA NA NA hsa-miR-590-3p PLCB1 0.750834112502691 0.0721409718537464 0.240859081180217 0.70209283187101 PITA;miRanda;mirMAP -0.434321818401397 7.14563817534753e-12 NA NA NA hsa-miR-590-5p PLCB1 0.763126350124264 0.184296330120049 0.240859081180217 0.70209283187101 PITA;miRanda -0.332840765702019 4.24457962179523e-08 NA NA NA hsa-miR-7-1-3p PLCB1 0.642828512342857 0.399017154673609 0.240859081180217 0.70209283187101 mirMAP -0.314047400885598 1.99798454903514e-07 NA NA NA hsa-miR-7-5p PLCB1 1.10068930642027 0.0314621365860381 0.240859081180217 0.70209283187101 miRNATAP -0.210343289628986 2.13858605288695e-05 NA NA NA hsa-miR-125a-5p PLCB3 -0.134418454752295 0.908401725750299 -0.11575951598417 0.901253448511555 miRanda -0.15684032508767 0.0111091757270735 NA NA NA hsa-let-7b-3p PLCB4 0.273132474559554 0.682533246372485 -0.201869182091545 0.758061378202267 mirMAP;miRNATAP -0.38287534712009 0.00428172389866833 NA NA NA hsa-let-7f-1-3p PLCB4 1.02975898416111 0.00216616040865014 -0.201869182091545 0.758061378202267 mirMAP -0.27756768427581 0.00646555031062187 NA NA NA hsa-let-7g-5p PLCB4 0.242876485228015 0.854288116985674 -0.201869182091545 0.758061378202267 miRNATAP -0.291015781494438 0.0333342889680225 NA NA NA hsa-miR-141-3p PLCB4 1.38768814668269 0.324793132237099 -0.201869182091545 0.758061378202267 TargetScan -0.111944795015411 0.0242253690615604 NA NA NA hsa-miR-16-2-3p PLCB4 0.73180598347188 0.153070057533699 -0.201869182091545 0.758061378202267 mirMAP -0.233015983104818 0.000840957415831306 NA NA NA hsa-miR-183-5p PLCB4 1.7493246062808 0.300980159489712 -0.201869182091545 0.758061378202267 miRNATAP -0.131734964788475 0.0157253349372858 NA NA NA hsa-miR-23a-3p PLCB4 0.727812777693753 0.65239699793942 -0.201869182091545 0.758061378202267 miRNATAP -0.815275562931676 2.27887551948845e-07 NA NA NA hsa-miR-454-3p PLCB4 0.737467730442439 0.0944172375936656 -0.201869182091545 0.758061378202267 miRNATAP -0.210898679661055 0.0281118429669635 NA NA NA hsa-miR-590-3p PLCB4 0.750834112502691 0.0721409718537464 -0.201869182091545 0.758061378202267 miRanda -0.266442768454214 0.000964385594306168 NA NA NA hsa-miR-455-5p PORCN 0.610591180666197 0.405984831720842 -0.349640114233168 0.47955312663867 miRanda -0.107749102123318 0.0040817607483859 NA NA NA hsa-miR-542-3p PORCN 1.09096556479387 0.289651874996689 -0.349640114233168 0.47955312663867 miRNATAP -0.202380518509814 3.59209696495348e-05 NA NA NA hsa-miR-421 PPP2CB 1.28183445098144 3.9841687793795e-06 -0.617839176319174 0.479973074396282 miRNAWalker2_validate;miRanda -0.114006096656868 9.23001960871675e-05 NA NA NA hsa-miR-125a-5p PPP2R1B -0.134418454752295 0.908401725750299 0.108270513078553 0.882590555393157 PITA;miRanda -0.10968035470595 0.00719472046068446 NA NA NA hsa-miR-139-5p PPP2R1B -1.31022051532559 0.0657735573826271 0.108270513078553 0.882590555393157 MirTarget;miRanda -0.137998716815882 4.88944980532178e-05 NA NA NA hsa-miR-195-5p PPP2R1B -0.954323940965843 0.175659217190861 0.108270513078553 0.882590555393157 MirTarget -0.13157210220167 8.49104716697063e-05 NA NA NA hsa-miR-30a-3p PPP2R1B -1.21767477941485 0.437259873660328 0.108270513078553 0.882590555393157 mirMAP -0.183101665830488 3.43061240330759e-10 NA NA NA hsa-miR-30a-5p PPP2R1B -0.622409301903435 0.733062880166898 0.108270513078553 0.882590555393157 miRNATAP -0.216706125776355 1.94228862060271e-09 NA NA NA hsa-miR-30c-2-3p PPP2R1B -0.730753355528392 0.223048822447852 0.108270513078553 0.882590555393157 MirTarget -0.17777311930786 6.56503377240636e-08 NA NA NA hsa-miR-497-5p PPP2R1B -0.365153126703569 0.562708968911863 0.108270513078553 0.882590555393157 MirTarget -0.116415602488678 0.00113149556019452 NA NA NA hsa-miR-185-3p PPP2R5B 1.29970093498066 0.00088003078050264 -0.31173102906923 0.597165486164578 MirTarget -0.160241626816619 1.77798553041735e-08 NA NA NA hsa-miR-330-5p PPP2R5B 0.522359698833297 0.46945472961169 -0.31173102906923 0.597165486164578 MirTarget;miRanda;miRNATAP -0.1157323889275 0.000211939170760146 NA NA NA hsa-miR-331-3p PPP2R5B 0.842954893306256 0.176786083671554 -0.31173102906923 0.597165486164578 MirTarget;miRNATAP -0.112963272079311 4.23573461221573e-05 NA NA NA hsa-miR-361-3p PPP2R5B 0.480275847363033 0.635924490895616 -0.31173102906923 0.597165486164578 MirTarget;miRNATAP -0.257798491617221 4.2719850477173e-09 NA NA NA hsa-miR-744-5p PPP2R5B 0.641448439137484 0.302165761763711 -0.31173102906923 0.597165486164578 MirTarget -0.190702304045959 1.53396062098763e-07 NA NA NA hsa-miR-107 PPP2R5C 0.808649908398562 0.357609254490153 -0.316272308576178 0.721793958570111 PITA;miRanda;miRNATAP -0.119876416568357 0.00082672538569924 NA NA NA hsa-miR-132-3p PPP2R5C 0.778103303628054 0.416119200227887 -0.316272308576178 0.721793958570111 miRNATAP -0.162957462542642 4.24279469856147e-06 NA NA NA hsa-miR-186-5p PPP2R5C 0.273626466122302 0.807169118774403 -0.316272308576178 0.721793958570111 mirMAP;miRNATAP -0.105707745748858 0.000517031529505707 NA NA NA hsa-miR-212-3p PPP2R5C 0.895869490569324 0.0316777138361649 -0.316272308576178 0.721793958570111 miRNATAP -0.14208437827145 5.60552180296949e-08 NA NA NA hsa-miR-26a-5p PPP2R5C -0.459645668105514 0.761702789258103 -0.316272308576178 0.721793958570111 mirMAP -0.117700239691979 0.00197791317059992 NA NA NA hsa-miR-330-5p PPP2R5C 0.522359698833297 0.46945472961169 -0.316272308576178 0.721793958570111 miRanda -0.106914317732635 1.44704556743694e-06 NA NA NA hsa-miR-455-5p PPP2R5C 0.610591180666197 0.405984831720842 -0.316272308576178 0.721793958570111 miRanda -0.101293956575555 1.66468210314825e-06 NA NA NA hsa-let-7a-3p PPP2R5E 0.180588894055192 0.807497649839616 0.0694367738371904 0.923306781906458 mirMAP -0.152013004078688 6.40942061701976e-09 NA NA NA hsa-let-7b-3p PPP2R5E 0.273132474559554 0.682533246372485 0.0694367738371904 0.923306781906458 mirMAP -0.13335253655319 0.000223053263719782 NA NA NA hsa-miR-101-5p PPP2R5E -0.233832762189834 0.545317272240313 0.0694367738371904 0.923306781906458 MirTarget -0.121008895745197 7.34347841776813e-06 NA NA NA hsa-miR-125a-5p PPP2R5E -0.134418454752295 0.908401725750299 0.0694367738371904 0.923306781906458 miRNAWalker2_validate -0.115290900111095 0.000109961913685151 NA NA NA hsa-miR-126-5p PPP2R5E 0.393018523145496 0.713269992183763 0.0694367738371904 0.923306781906458 MirTarget;mirMAP -0.132162545995022 1.57684680695321e-06 NA NA NA hsa-miR-130a-3p PPP2R5E 0.410890280285832 0.607447245204235 0.0694367738371904 0.923306781906458 mirMAP -0.111762442096547 5.93173204059191e-06 NA NA NA hsa-miR-30b-5p PPP2R5E -0.124247247359659 0.917685196303453 0.0694367738371904 0.923306781906458 mirMAP -0.146469303582984 1.35098688754856e-08 NA NA NA hsa-miR-30c-5p PPP2R5E -0.208331154216021 0.863518338736092 0.0694367738371904 0.923306781906458 mirMAP -0.116397782860685 0.000213250793254969 NA NA NA hsa-miR-30e-3p PPP2R5E -0.528630634076661 0.752496184625955 0.0694367738371904 0.923306781906458 MirTarget -0.165212303497102 2.0691619880076e-05 NA NA NA hsa-miR-30e-5p PPP2R5E -0.318933868943279 0.850982406429589 0.0694367738371904 0.923306781906458 mirMAP -0.144163935567684 5.81678356434172e-05 NA NA NA hsa-miR-374a-3p PPP2R5E 0.00444091189256923 0.997279477304268 0.0694367738371904 0.923306781906458 MirTarget -0.134474500922421 0.000302651646753834 NA NA NA hsa-miR-374a-5p PPP2R5E 0.280580933704653 0.711312203580958 0.0694367738371904 0.923306781906458 mirMAP -0.13809758813922 0.00540322372732104 NA NA NA hsa-miR-374b-5p PPP2R5E 0.00830204566239612 0.992518773949115 0.0694367738371904 0.923306781906458 mirMAP -0.188230496751383 2.32502986256914e-07 NA NA NA hsa-miR-454-3p PPP2R5E 0.737467730442439 0.0944172375936656 0.0694367738371904 0.923306781906458 mirMAP -0.106204556999545 3.64813371995072e-05 NA NA NA hsa-miR-590-3p PPP2R5E 0.750834112502691 0.0721409718537464 0.0694367738371904 0.923306781906458 MirTarget;PITA;miRanda;mirMAP -0.110341844526814 3.07907172330384e-07 NA NA NA hsa-miR-374b-3p PPP3CA 0.224020026912894 0.351409936209018 0.256513535290416 0.757697050301001 MirTarget -0.125486121489674 0.000113682941271975 NA NA NA hsa-miR-99b-5p PPP3CA 0.153985653255864 0.936392578438142 0.256513535290416 0.757697050301001 MirTarget -0.114221393713984 0.00286006149815181 NA NA NA hsa-miR-107 PPP3CB 0.808649908398562 0.357609254490153 -0.346590249596662 0.636489944780521 miRanda -0.288367048854735 2.92508755791905e-09 NA NA NA hsa-miR-10b-5p PPP3CB -0.349066414045252 0.854598143201285 -0.346590249596662 0.636489944780521 miRNAWalker2_validate -0.100528648474207 0.0076769423338973 NA NA NA hsa-miR-140-5p PPP3CB 0.0863677120902411 0.909387194440856 -0.346590249596662 0.636489944780521 miRanda -0.187414441965582 1.25912301040941e-07 NA NA NA hsa-miR-146b-5p PPP3CB 2.36576014745762 0.0657344824311623 -0.346590249596662 0.636489944780521 miRanda -0.164512260559993 6.69154707753253e-11 NA NA NA hsa-miR-15a-5p PPP3CB 0.999503864534946 0.325292066441584 -0.346590249596662 0.636489944780521 miRNATAP -0.228290467215453 5.86207137940529e-11 NA NA NA hsa-miR-15b-5p PPP3CB 0.441873888832829 0.683456288766732 -0.346590249596662 0.636489944780521 miRNATAP -0.257607887149993 3.16794050944625e-15 NA NA NA hsa-miR-16-5p PPP3CB 0.294875982844909 0.811640142720194 -0.346590249596662 0.636489944780521 miRNATAP -0.238877122232723 7.04452900892349e-17 NA NA NA hsa-miR-20a-3p PPP3CB 0.44568974632412 0.380391798091882 -0.346590249596662 0.636489944780521 miRNATAP -0.134720661118285 7.02707692910211e-11 NA NA NA hsa-miR-26a-5p PPP3CB -0.459645668105514 0.761702789258103 -0.346590249596662 0.636489944780521 MirTarget;miRNATAP -0.15748401777196 0.00284028972291063 NA NA NA hsa-miR-26b-5p PPP3CB -0.640970973524183 0.623642285963207 -0.346590249596662 0.636489944780521 MirTarget;miRNATAP -0.169263655449838 8.48795995650111e-08 NA NA NA hsa-miR-320b PPP3CB 0.941267876385794 0.0453505938355543 -0.346590249596662 0.636489944780521 miRanda -0.166916823932829 9.2484091369528e-12 NA NA NA hsa-miR-326 PPP3CB -0.686277598234758 0.130157755184283 -0.346590249596662 0.636489944780521 MirTarget;PITA;miRanda -0.119889598422512 2.94925975525176e-07 NA NA NA hsa-miR-330-5p PPP3CB 0.522359698833297 0.46945472961169 -0.346590249596662 0.636489944780521 MirTarget;PITA;miRanda -0.209582580904677 2.98485755337729e-12 NA NA NA hsa-miR-339-5p PPP3CB 0.515631910744412 0.482415357074891 -0.346590249596662 0.636489944780521 miRanda -0.155934892500875 1.06748223210035e-11 NA NA NA hsa-miR-342-3p PPP3CB 0.35619281153521 0.696985677902105 -0.346590249596662 0.636489944780521 miRanda -0.104683313030798 0.000255990810106459 NA NA NA hsa-miR-361-5p PPP3CB 0.517068298358111 0.640548482802509 -0.346590249596662 0.636489944780521 miRanda -0.17464362517354 0.00556809094507137 NA NA NA hsa-miR-369-3p PPP3CB 0.658307572343713 0.108939404101946 -0.346590249596662 0.636489944780521 mirMAP -0.152903945305437 1.82424985009585e-06 NA NA NA hsa-miR-421 PPP3CB 1.28183445098144 3.9841687793795e-06 -0.346590249596662 0.636489944780521 miRanda -0.125686484899785 4.53016255884588e-06 NA NA NA hsa-miR-424-5p PPP3CB 0.778229637040266 0.39502076082444 -0.346590249596662 0.636489944780521 miRNATAP -0.186928116987328 5.19541271867053e-17 NA NA NA hsa-miR-429 PPP3CB 1.19781217693135 0.322310054579944 -0.346590249596662 0.636489944780521 miRanda -0.142621990530858 7.32416257804096e-21 NA NA NA hsa-miR-450b-5p PPP3CB 1.31989436603254 0.00773738577557236 -0.346590249596662 0.636489944780521 MirTarget;PITA;miRNATAP -0.197124450428441 4.18667889320484e-12 NA NA NA hsa-miR-493-5p PPP3CB 1.34217716159816 0.00369808454520068 -0.346590249596662 0.636489944780521 miRNATAP -0.145554803198721 5.21060803157266e-07 NA NA NA hsa-miR-501-5p PPP3CB 1.51510872844603 0.000249681492153084 -0.346590249596662 0.636489944780521 PITA;miRNATAP -0.168802236162234 5.95508853838858e-13 NA NA NA hsa-miR-590-3p PPP3CB 0.750834112502691 0.0721409718537464 -0.346590249596662 0.636489944780521 miRanda -0.262264024295873 5.03208562495967e-24 NA NA NA hsa-miR-7-1-3p PPP3CB 0.642828512342857 0.399017154673609 -0.346590249596662 0.636489944780521 mirMAP -0.211372678454912 2.41258242120576e-17 NA NA NA hsa-miR-361-5p PPP3CC 0.517068298358111 0.640548482802509 -0.318792257436448 0.512926554684327 miRanda -0.23664752091267 0.00504602062919921 NA NA NA hsa-miR-500a-3p PPP3CC 1.37621558353076 0.232455766282991 -0.318792257436448 0.512926554684327 MirTarget;miRNATAP -0.139850016811968 0.000184052942707902 NA NA NA hsa-miR-501-3p PPP3CC 1.73058403233275 0.0341144346170376 -0.318792257436448 0.512926554684327 MirTarget;PITA;miRNATAP -0.126911603513412 0.000133172429563842 NA NA NA hsa-miR-502-3p PPP3CC 0.928680556499737 0.0961567944204266 -0.318792257436448 0.512926554684327 MirTarget;PITA;miRNATAP -0.141769756339311 0.00105371895784409 NA NA NA hsa-miR-26a-5p PPP3R1 -0.459645668105514 0.761702789258103 0.183282956998971 0.82837843990251 MirTarget;miRNATAP -0.140127759208005 1.445801018965e-06 NA NA NA hsa-miR-30a-5p PPP3R1 -0.622409301903435 0.733062880166898 0.183282956998971 0.82837843990251 miRNAWalker2_validate;MirTarget;miRNATAP -0.112947134457648 3.79610942883174e-09 NA NA NA hsa-miR-141-3p PRICKLE1 1.38768814668269 0.324793132237099 0.227623188091891 0.593431767275807 TargetScan -0.353916241833008 4.00257366535127e-18 NA NA NA hsa-miR-17-5p PRICKLE1 1.42323729519248 0.26500282246461 0.227623188091891 0.593431767275807 miRNAWalker2_validate -0.570094469907719 1.32633454461084e-21 NA NA NA hsa-miR-192-5p PRICKLE1 1.83864778676109 0.37609734647626 0.227623188091891 0.593431767275807 miRNAWalker2_validate -0.287669113783684 2.62804395951269e-13 NA NA NA hsa-miR-215-5p PRICKLE1 0.782657078958936 0.568836776061539 0.227623188091891 0.593431767275807 miRNAWalker2_validate -0.162280425110027 5.23143532711894e-07 NA NA NA hsa-miR-30b-5p PRICKLE1 -0.124247247359659 0.917685196303453 0.227623188091891 0.593431767275807 mirMAP -0.362799762298805 1.75702059606039e-05 NA NA NA hsa-miR-30c-5p PRICKLE1 -0.208331154216021 0.863518338736092 0.227623188091891 0.593431767275807 miRNATAP -0.269773292539275 0.00837565189064297 NA NA NA hsa-miR-30d-5p PRICKLE1 0.218119609086939 0.898751473051369 0.227623188091891 0.593431767275807 miRNATAP -0.897217629923453 2.4433504632195e-11 NA NA NA hsa-miR-330-3p PRICKLE1 0.237023779714759 0.466174401969581 0.227623188091891 0.593431767275807 mirMAP;miRNATAP -0.308335366831348 0.000114716687168624 NA NA NA hsa-miR-338-3p PRICKLE1 -0.0828798547902423 0.951212804477186 0.227623188091891 0.593431767275807 miRanda -0.310595433635639 6.99404067413564e-07 NA NA NA hsa-miR-3607-3p PRICKLE1 0.402426470225138 0.613303667114625 0.227623188091891 0.593431767275807 miRNATAP -0.141178484289213 0.000310984151787659 NA NA NA hsa-miR-361-5p PRICKLE1 0.517068298358111 0.640548482802509 0.227623188091891 0.593431767275807 miRanda -0.401574317000918 0.0111010823432414 NA NA NA hsa-miR-532-5p PRICKLE1 1.37200327675848 0.338407542476233 0.227623188091891 0.593431767275807 miRNATAP -0.60596318268238 2.30073533216393e-15 NA NA NA hsa-miR-582-5p PRICKLE1 -0.0750818699965312 0.895875799292592 0.227623188091891 0.593431767275807 miRNATAP -0.358740350301525 2.84757496236403e-06 NA NA NA hsa-let-7a-3p PRICKLE2 0.180588894055192 0.807497649839616 -0.813868099921637 0.159584820168163 mirMAP -0.844235438436495 1.75611283529867e-21 NA NA NA hsa-let-7b-3p PRICKLE2 0.273132474559554 0.682533246372485 -0.813868099921637 0.159584820168163 mirMAP -0.95103532522183 1.38880400014269e-14 NA NA NA hsa-let-7f-1-3p PRICKLE2 1.02975898416111 0.00216616040865014 -0.813868099921637 0.159584820168163 mirMAP -0.944385661735152 5.71464634715896e-26 NA NA NA hsa-miR-10b-3p PRICKLE2 0.360517031366521 0.325264998344862 -0.813868099921637 0.159584820168163 mirMAP -0.500764024504212 2.01667669882508e-06 NA NA NA hsa-miR-130b-5p PRICKLE2 1.29600920697695 0.0255462581963971 -0.813868099921637 0.159584820168163 mirMAP -0.689132189514262 3.07632439894597e-46 NA NA NA hsa-miR-132-3p PRICKLE2 0.778103303628054 0.416119200227887 -0.813868099921637 0.159584820168163 MirTarget;miRNATAP -0.381318772424881 0.00558021360374134 NA NA NA hsa-miR-146a-5p PRICKLE2 0.67061946633831 0.538820409992621 -0.813868099921637 0.159584820168163 mirMAP -0.608021416965813 1.53617236241166e-26 NA NA NA hsa-miR-148a-3p PRICKLE2 -0.336734438265406 0.874732520340819 -0.813868099921637 0.159584820168163 MirTarget;miRNATAP -0.599790943298439 1.70836282023969e-22 NA NA NA hsa-miR-148a-5p PRICKLE2 -0.0671657147202627 0.935632562211656 -0.813868099921637 0.159584820168163 mirMAP -0.597063626527624 2.3486234844347e-20 NA NA NA hsa-miR-148b-3p PRICKLE2 0.686272171036606 0.498004854065858 -0.813868099921637 0.159584820168163 MirTarget;miRNATAP -1.1161184460537 7.30838187440273e-37 NA NA NA hsa-miR-150-5p PRICKLE2 0.481167647702842 0.709626991980819 -0.813868099921637 0.159584820168163 MirTarget -0.18812340897058 0.0025315557181657 NA NA NA hsa-miR-15b-3p PRICKLE2 0.616287210571229 0.422509520506848 -0.813868099921637 0.159584820168163 mirMAP -0.850004896639346 7.02983810383907e-45 NA NA NA hsa-miR-16-2-3p PRICKLE2 0.73180598347188 0.153070057533699 -0.813868099921637 0.159584820168163 mirMAP -0.739955473761954 7.33758462443682e-36 NA NA NA hsa-miR-181a-5p PRICKLE2 1.4443526859599 0.296372990368445 -0.813868099921637 0.159584820168163 mirMAP;miRNATAP -0.572616734997522 5.86278230371728e-09 NA NA NA hsa-miR-181b-5p PRICKLE2 1.46153693463023 0.179461012757425 -0.813868099921637 0.159584820168163 mirMAP;miRNATAP -0.584569861276527 3.01765728682163e-11 NA NA NA hsa-miR-182-5p PRICKLE2 1.43665900078936 0.443507432581923 -0.813868099921637 0.159584820168163 MirTarget -0.673899051052427 1.73364555959778e-43 NA NA NA hsa-miR-186-5p PRICKLE2 0.273626466122302 0.807169118774403 -0.813868099921637 0.159584820168163 MirTarget -1.11185274750009 2.44101454162872e-25 NA NA NA hsa-miR-18a-5p PRICKLE2 1.93049155460812 0.00663833971152871 -0.813868099921637 0.159584820168163 MirTarget -0.6317841942329 9.42700264095972e-35 NA NA NA hsa-miR-194-5p PRICKLE2 1.98051780248547 0.297931251695511 -0.813868099921637 0.159584820168163 miRNATAP -0.479817287738785 2.89054539067797e-27 NA NA NA hsa-miR-197-3p PRICKLE2 0.410934526674329 0.714594021648229 -0.813868099921637 0.159584820168163 mirMAP -0.843755965958963 7.39994280723286e-23 NA NA NA hsa-miR-19a-3p PRICKLE2 1.64946154674522 0.0268746411162676 -0.813868099921637 0.159584820168163 MirTarget;miRNATAP -0.695869127627454 1.0013091329571e-31 NA NA NA hsa-miR-19b-3p PRICKLE2 0.806034733762941 0.431963517845538 -0.813868099921637 0.159584820168163 MirTarget;miRNATAP -0.893828109986248 5.31783387000266e-35 NA NA NA hsa-miR-203a-3p PRICKLE2 0.611075025115978 0.739204964576711 -0.813868099921637 0.159584820168163 MirTarget -0.408073152596206 1.0553156456381e-21 NA NA NA hsa-miR-21-5p PRICKLE2 2.24244475408756 0.372600191183534 -0.813868099921637 0.159584820168163 miRNAWalker2_validate;MirTarget -0.608807390651799 1.54800519379245e-10 NA NA NA hsa-miR-212-3p PRICKLE2 0.895869490569324 0.0316777138361649 -0.813868099921637 0.159584820168163 MirTarget;miRNATAP -0.560715502333574 2.14589694095334e-08 NA NA NA hsa-miR-26a-2-3p PRICKLE2 0.0416400673740434 0.887900422135032 -0.813868099921637 0.159584820168163 mirMAP -0.394574498723786 4.31902220541208e-06 NA NA NA hsa-miR-27a-3p PRICKLE2 0.505339123854064 0.734502884016765 -0.813868099921637 0.159584820168163 MirTarget;miRNATAP -1.05141017012889 1.47728461096929e-17 NA NA NA hsa-miR-29a-3p PRICKLE2 -0.289266265366038 0.873126628905318 -0.813868099921637 0.159584820168163 MirTarget;miRNATAP -0.715618808784789 5.15585711169471e-11 NA NA NA hsa-miR-29b-3p PRICKLE2 -0.0266375641487411 0.98423866564075 -0.813868099921637 0.159584820168163 MirTarget;miRNATAP -0.727947576877143 3.18376261461768e-20 NA NA NA hsa-miR-320a PRICKLE2 0.22287875340213 0.865731646872282 -0.813868099921637 0.159584820168163 mirMAP -0.455500960693656 7.22038653286851e-06 NA NA NA hsa-miR-320b PRICKLE2 0.941267876385794 0.0453505938355543 -0.813868099921637 0.159584820168163 mirMAP -0.594118431446419 1.26799807744833e-19 NA NA NA hsa-miR-326 PRICKLE2 -0.686277598234758 0.130157755184283 -0.813868099921637 0.159584820168163 miRanda;miRNATAP -0.339806873558313 1.4430342183423e-07 NA NA NA hsa-miR-330-3p PRICKLE2 0.237023779714759 0.466174401969581 -0.813868099921637 0.159584820168163 MirTarget -0.674825851702599 1.15263332548608e-15 NA NA NA hsa-miR-330-5p PRICKLE2 0.522359698833297 0.46945472961169 -0.813868099921637 0.159584820168163 miRanda;miRNATAP -0.848248910541586 1.58778922807048e-27 NA NA NA hsa-miR-335-3p PRICKLE2 2.25543430538924 0.0139006907758541 -0.813868099921637 0.159584820168163 mirMAP -0.521739130714876 4.19724172877542e-19 NA NA NA hsa-miR-335-5p PRICKLE2 0.484676450705085 0.267046535449854 -0.813868099921637 0.159584820168163 miRNAWalker2_validate -0.504091129430925 3.0339499457329e-13 NA NA NA hsa-miR-33a-3p PRICKLE2 -0.0493858782224366 0.86469054162599 -0.813868099921637 0.159584820168163 mirMAP -0.674954818626767 4.22072923508816e-21 NA NA NA hsa-miR-33a-5p PRICKLE2 0.179538686749402 0.795042829975416 -0.813868099921637 0.159584820168163 MirTarget -0.425106701172023 2.4153004926959e-24 NA NA NA hsa-miR-361-5p PRICKLE2 0.517068298358111 0.640548482802509 -0.813868099921637 0.159584820168163 MirTarget;PITA;miRanda;miRNATAP -0.710004109191109 3.95975848057282e-05 NA NA NA hsa-miR-362-5p PRICKLE2 1.36961823784152 0.0184116687226066 -0.813868099921637 0.159584820168163 mirMAP -0.502297024976965 7.68176043131165e-15 NA NA NA hsa-miR-369-3p PRICKLE2 0.658307572343713 0.108939404101946 -0.813868099921637 0.159584820168163 PITA;mirMAP -0.440837390843237 6.25332501491819e-07 NA NA NA hsa-miR-374a-3p PRICKLE2 0.00444091189256923 0.997279477304268 -0.813868099921637 0.159584820168163 MirTarget;miRNATAP -0.519493977798156 8.85681447865399e-05 NA NA NA hsa-miR-421 PRICKLE2 1.28183445098144 3.9841687793795e-06 -0.813868099921637 0.159584820168163 miRanda -0.570793256487138 5.59188699979642e-15 NA NA NA hsa-miR-429 PRICKLE2 1.19781217693135 0.322310054579944 -0.813868099921637 0.159584820168163 miRNATAP -0.52232151053116 2.91846706715451e-41 NA NA NA hsa-miR-450b-5p PRICKLE2 1.31989436603254 0.00773738577557236 -0.813868099921637 0.159584820168163 MirTarget;mirMAP;miRNATAP -0.540151342846487 6.92693300543801e-12 NA NA NA hsa-miR-484 PRICKLE2 0.340101271888636 0.69389289011036 -0.813868099921637 0.159584820168163 miRNATAP -0.792536857724732 3.12904637346205e-23 NA NA NA hsa-miR-500a-5p PRICKLE2 1.23668772656115 0.0116556612443014 -0.813868099921637 0.159584820168163 mirMAP -0.632750259786621 1.26188434294792e-25 NA NA NA hsa-miR-574-3p PRICKLE2 0.111984999692259 0.900462447976973 -0.813868099921637 0.159584820168163 PITA -0.355317410943687 0.000257895108422631 NA NA NA hsa-miR-576-5p PRICKLE2 0.744407899578399 0.146981973135162 -0.813868099921637 0.159584820168163 mirMAP -0.844582360467453 1.05137829604621e-31 NA NA NA hsa-miR-589-3p PRICKLE2 0.91523747397743 0.0032660296472646 -0.813868099921637 0.159584820168163 MirTarget -0.666967899621896 9.69706717877144e-24 NA NA NA hsa-miR-589-5p PRICKLE2 1.1821804664823 0.162299570206384 -0.813868099921637 0.159584820168163 MirTarget;miRNATAP -0.947707702488155 1.05129054690914e-22 NA NA NA hsa-miR-590-3p PRICKLE2 0.750834112502691 0.0721409718537464 -0.813868099921637 0.159584820168163 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.884965710790469 3.3376821646475e-39 NA NA NA hsa-miR-590-5p PRICKLE2 0.763126350124264 0.184296330120049 -0.813868099921637 0.159584820168163 MirTarget;PITA;miRanda -0.762193143896531 5.43491437990252e-31 NA NA NA hsa-miR-624-5p PRICKLE2 0.169826271489341 0.476665062689913 -0.813868099921637 0.159584820168163 mirMAP -0.625794331949791 3.14154330452747e-13 NA NA NA hsa-miR-628-5p PRICKLE2 -0.147840687690768 0.737579441803487 -0.813868099921637 0.159584820168163 PITA;miRNATAP -0.520188729062742 7.51966976027982e-09 NA NA NA hsa-miR-629-3p PRICKLE2 0.551260052178687 0.20899418574898 -0.813868099921637 0.159584820168163 MirTarget -0.616980909571793 1.14422660255278e-28 NA NA NA hsa-miR-664a-3p PRICKLE2 -0.0286436952305813 0.961537804671418 -0.813868099921637 0.159584820168163 mirMAP -0.288873748782152 0.017838517855927 NA NA NA hsa-miR-664a-5p PRICKLE2 -0.245538311240215 0.360416705748091 -0.813868099921637 0.159584820168163 MirTarget -0.272385757096659 0.00120519277170531 NA NA NA hsa-miR-7-1-3p PRICKLE2 0.642828512342857 0.399017154673609 -0.813868099921637 0.159584820168163 MirTarget -0.770010236898208 1.87526521823838e-32 NA NA NA hsa-miR-146b-5p PRKACA 2.36576014745762 0.0657344824311623 -0.288061805718867 0.742341189408727 PITA -0.101906530501573 1.08208425196835e-07 NA NA NA hsa-miR-15a-5p PRKACA 0.999503864534946 0.325292066441584 -0.288061805718867 0.742341189408727 miRNATAP -0.112153197907765 2.88199794515075e-05 NA NA NA hsa-miR-15b-5p PRKACA 0.441873888832829 0.683456288766732 -0.288061805718867 0.742341189408727 miRNATAP -0.130092085496616 2.92125969703536e-07 NA NA NA hsa-miR-590-3p PRKACA 0.750834112502691 0.0721409718537464 -0.288061805718867 0.742341189408727 miRanda -0.114824715780153 3.3879176865622e-08 NA NA NA hsa-let-7a-3p PRKACB 0.180588894055192 0.807497649839616 -0.525359425857642 0.458555161654351 MirTarget;mirMAP;miRNATAP -0.386654938607141 2.89363024981146e-09 NA NA NA hsa-let-7b-3p PRKACB 0.273132474559554 0.682533246372485 -0.525359425857642 0.458555161654351 MirTarget;mirMAP;miRNATAP -0.586928490709956 1.84163383683316e-11 NA NA NA hsa-let-7d-3p PRKACB 0.555592421135096 0.64170973889979 -0.525359425857642 0.458555161654351 MirTarget -0.540563143213791 1.15827914597495e-16 NA NA NA hsa-let-7f-1-3p PRKACB 1.02975898416111 0.00216616040865014 -0.525359425857642 0.458555161654351 MirTarget;mirMAP -0.576273872321095 3.13340207560098e-19 NA NA NA hsa-miR-126-5p PRKACB 0.393018523145496 0.713269992183763 -0.525359425857642 0.458555161654351 mirMAP -0.397922806085586 4.46582951091209e-09 NA NA NA hsa-miR-141-3p PRKACB 1.38768814668269 0.324793132237099 -0.525359425857642 0.458555161654351 MirTarget;TargetScan;miRNATAP -0.256345854032607 5.98601047238794e-16 NA NA NA hsa-miR-146b-5p PRKACB 2.36576014745762 0.0657344824311623 -0.525359425857642 0.458555161654351 miRanda -0.222335190553625 7.68995540057384e-06 NA NA NA hsa-miR-16-2-3p PRKACB 0.73180598347188 0.153070057533699 -0.525359425857642 0.458555161654351 mirMAP -0.345216491469143 1.81979508952357e-14 NA NA NA hsa-miR-17-5p PRKACB 1.42323729519248 0.26500282246461 -0.525359425857642 0.458555161654351 TargetScan -0.332200234149466 3.71233425032518e-12 NA NA NA hsa-miR-182-5p PRKACB 1.43665900078936 0.443507432581923 -0.525359425857642 0.458555161654351 MirTarget;miRNATAP -0.280078465945988 3.0310647810373e-13 NA NA NA hsa-miR-183-5p PRKACB 1.7493246062808 0.300980159489712 -0.525359425857642 0.458555161654351 MirTarget -0.292292744899958 3.20129643235052e-17 NA NA NA hsa-miR-18a-5p PRKACB 1.93049155460812 0.00663833971152871 -0.525359425857642 0.458555161654351 miRNATAP -0.276164612892176 2.02423419558116e-12 NA NA NA hsa-miR-193a-3p PRKACB 0.125692968009939 0.782518392846951 -0.525359425857642 0.458555161654351 miRanda -0.214876657779171 0.00364364770510541 NA NA NA hsa-miR-194-3p PRKACB 1.69586201919604 0.103388813689903 -0.525359425857642 0.458555161654351 MirTarget -0.211253403548211 6.3090213559711e-11 NA NA NA hsa-miR-19a-3p PRKACB 1.64946154674522 0.0268746411162676 -0.525359425857642 0.458555161654351 MirTarget;miRNATAP -0.275437489880617 1.26516324985696e-09 NA NA NA hsa-miR-19b-3p PRKACB 0.806034733762941 0.431963517845538 -0.525359425857642 0.458555161654351 miRNAWalker2_validate;MirTarget;miRNATAP -0.347044836408449 5.62485948508447e-10 NA NA NA hsa-miR-200a-3p PRKACB 1.70193303671238 0.209370802942576 -0.525359425857642 0.458555161654351 MirTarget;miRNATAP -0.230161657673416 3.98047541676119e-13 NA NA NA hsa-miR-200b-3p PRKACB 1.76966404687048 0.251078084855527 -0.525359425857642 0.458555161654351 MirTarget;TargetScan -0.246879516070806 1.51468418809723e-12 NA NA NA hsa-miR-200c-3p PRKACB 1.38059869033872 0.459075461573504 -0.525359425857642 0.458555161654351 MirTarget;miRNATAP -0.288984018724266 7.6966325782007e-16 NA NA NA hsa-miR-2110 PRKACB 0.359978603621206 0.164447205047607 -0.525359425857642 0.458555161654351 MirTarget -0.169373194336477 0.00234144535869815 NA NA NA hsa-miR-30d-3p PRKACB -0.0804985653060761 0.825203889451817 -0.525359425857642 0.458555161654351 mirMAP -0.301530555109323 7.76213725274813e-05 NA NA NA hsa-miR-323a-3p PRKACB 0.31643910302896 0.392958762081752 -0.525359425857642 0.458555161654351 mirMAP -0.203580453435581 2.63171092706358e-06 NA NA NA hsa-miR-330-3p PRKACB 0.237023779714759 0.466174401969581 -0.525359425857642 0.458555161654351 MirTarget -0.260830470600077 2.14091653746826e-05 NA NA NA hsa-miR-339-5p PRKACB 0.515631910744412 0.482415357074891 -0.525359425857642 0.458555161654351 miRanda -0.20526841263834 6.0588919349807e-06 NA NA NA hsa-miR-34a-5p PRKACB 0.563661494017221 0.590317849063448 -0.525359425857642 0.458555161654351 miRNATAP -0.375860755898472 1.13200739595526e-10 NA NA NA hsa-miR-361-5p PRKACB 0.517068298358111 0.640548482802509 -0.525359425857642 0.458555161654351 miRanda -0.366190990967506 0.00257336238284408 NA NA NA hsa-miR-362-3p PRKACB 0.888146502223775 0.0147453056709009 -0.525359425857642 0.458555161654351 PITA;miRanda;miRNATAP -0.321219602047122 1.5030783180778e-10 NA NA NA hsa-miR-362-5p PRKACB 1.36961823784152 0.0184116687226066 -0.525359425857642 0.458555161654351 PITA -0.274329529892276 2.80574279926103e-09 NA NA NA hsa-miR-3653-3p PRKACB 0.633424200635214 0.120436672464276 -0.525359425857642 0.458555161654351 MirTarget -0.249214432468883 8.26163586601685e-11 NA NA NA hsa-miR-370-3p PRKACB 0.927437491650734 0.0141918002855931 -0.525359425857642 0.458555161654351 MirTarget -0.163042986494033 0.00433490677410771 NA NA NA hsa-miR-409-3p PRKACB 1.06826077189128 0.086796304502529 -0.525359425857642 0.458555161654351 PITA;mirMAP -0.273401572012192 3.63112252497909e-05 NA NA NA hsa-miR-421 PRKACB 1.28183445098144 3.9841687793795e-06 -0.525359425857642 0.458555161654351 PITA;miRanda -0.256689079921464 1.16047269650081e-06 NA NA NA hsa-miR-429 PRKACB 1.19781217693135 0.322310054579944 -0.525359425857642 0.458555161654351 MirTarget;PITA;miRanda;miRNATAP -0.221632837696178 2.70031832694709e-13 NA NA NA hsa-miR-450b-5p PRKACB 1.31989436603254 0.00773738577557236 -0.525359425857642 0.458555161654351 mirMAP -0.221653001784828 9.04313673907005e-05 NA NA NA hsa-miR-532-5p PRKACB 1.37200327675848 0.338407542476233 -0.525359425857642 0.458555161654351 PITA -0.476336592439424 5.04174161089628e-16 NA NA NA hsa-miR-577 PRKACB 0.356857462342957 0.638858200569284 -0.525359425857642 0.458555161654351 PITA -0.169614691366841 1.42372586759292e-10 NA NA NA hsa-miR-582-5p PRKACB -0.0750818699965312 0.895875799292592 -0.525359425857642 0.458555161654351 MirTarget;PITA;miRNATAP -0.154280841451621 0.009967661063768 NA NA NA hsa-miR-590-3p PRKACB 0.750834112502691 0.0721409718537464 -0.525359425857642 0.458555161654351 MirTarget;PITA;miRanda;miRNATAP -0.320122146625047 1.76383529639608e-09 NA NA NA hsa-miR-590-5p PRKACB 0.763126350124264 0.184296330120049 -0.525359425857642 0.458555161654351 miRanda -0.344981860596061 3.62378560218264e-12 NA NA NA hsa-miR-7-1-3p PRKACB 0.642828512342857 0.399017154673609 -0.525359425857642 0.458555161654351 mirMAP -0.387118981958566 1.50211964600021e-15 NA NA NA hsa-miR-93-5p PRKACB 1.60480485311451 0.351308047161304 -0.525359425857642 0.458555161654351 miRNAWalker2_validate -0.300730482168819 1.70726962925971e-08 NA NA NA hsa-miR-96-5p PRKACB 1.14766037573765 0.0779994051337465 -0.525359425857642 0.458555161654351 miRNATAP -0.252420090079705 8.70159560330289e-11 NA NA NA hsa-miR-130b-5p PRKCA 1.29600920697695 0.0255462581963971 0.0964936153062848 0.909344626000501 mirMAP -0.171429439352642 1.11587242779179e-07 NA NA NA hsa-miR-142-5p PRKCA 1.06109968632125 0.257318725443238 0.0964936153062848 0.909344626000501 mirMAP -0.201699348683102 4.90622211911232e-09 NA NA NA hsa-miR-146a-5p PRKCA 0.67061946633831 0.538820409992621 0.0964936153062848 0.909344626000501 mirMAP -0.134655117045737 0.000168655004061988 NA NA NA hsa-miR-146b-5p PRKCA 2.36576014745762 0.0657344824311623 0.0964936153062848 0.909344626000501 mirMAP -0.153446820240124 0.000184746526922487 NA NA NA hsa-miR-150-5p PRKCA 0.481167647702842 0.709626991980819 0.0964936153062848 0.909344626000501 mirMAP -0.11417009540347 0.00136937649658156 NA NA NA hsa-miR-17-3p PRKCA 1.29395595671088 0.285254165683477 0.0964936153062848 0.909344626000501 miRNAWalker2_validate -0.147001861502741 0.00389289286055175 NA NA NA hsa-miR-181a-5p PRKCA 1.4443526859599 0.296372990368445 0.0964936153062848 0.909344626000501 mirMAP -0.154420913800487 0.0075638434939541 NA NA NA hsa-miR-181b-5p PRKCA 1.46153693463023 0.179461012757425 0.0964936153062848 0.909344626000501 mirMAP -0.174977550140736 0.000762630434910308 NA NA NA hsa-miR-183-5p PRKCA 1.7493246062808 0.300980159489712 0.0964936153062848 0.909344626000501 miRNATAP -0.164389215726407 2.54415883337075e-08 NA NA NA hsa-miR-186-5p PRKCA 0.273626466122302 0.807169118774403 0.0964936153062848 0.909344626000501 miRNATAP -0.221697868181595 0.000931727846842534 NA NA NA hsa-miR-193b-3p PRKCA 0.0161770988395791 0.982986487056008 0.0964936153062848 0.909344626000501 miRNAWalker2_validate -0.193110122301387 2.10396201485406e-05 NA NA NA hsa-miR-193b-5p PRKCA -0.238255317927168 0.448150911758541 0.0964936153062848 0.909344626000501 mirMAP -0.169015187187549 6.14294801577059e-05 NA NA NA hsa-miR-1976 PRKCA 0.789785650452199 0.0990760500738296 0.0964936153062848 0.909344626000501 miRNATAP -0.157226968706441 0.00171083118695891 NA NA NA hsa-miR-19b-1-5p PRKCA 1.68690066069614 0.001519169322997 0.0964936153062848 0.909344626000501 mirMAP -0.13376908140152 0.001378722474083 NA NA NA hsa-miR-200b-3p PRKCA 1.76966404687048 0.251078084855527 0.0964936153062848 0.909344626000501 TargetScan -0.108241426571207 0.000262578924015237 NA NA NA hsa-miR-200c-3p PRKCA 1.38059869033872 0.459075461573504 0.0964936153062848 0.909344626000501 miRNATAP -0.143387067513447 2.87423908201966e-06 NA NA NA hsa-miR-22-5p PRKCA 0.563707897845906 0.429790318970966 0.0964936153062848 0.909344626000501 mirMAP -0.177396983928844 0.00031979687771852 NA NA NA hsa-miR-2355-3p PRKCA 0.0922515944773004 0.789430438736429 0.0964936153062848 0.909344626000501 mirMAP -0.138975286803926 0.000678989115010752 NA NA NA hsa-miR-29a-5p PRKCA 0.868963854135301 0.0539172641542065 0.0964936153062848 0.909344626000501 mirMAP -0.178440639441324 0.000325239329279153 NA NA NA hsa-miR-30e-3p PRKCA -0.528630634076661 0.752496184625955 0.0964936153062848 0.909344626000501 mirMAP -0.180113558224167 0.0249887788929294 NA NA NA hsa-miR-330-3p PRKCA 0.237023779714759 0.466174401969581 0.0964936153062848 0.909344626000501 mirMAP -0.224482956128231 8.11117341984718e-06 NA NA NA hsa-miR-340-5p PRKCA 0.390142516048182 0.456452075825761 0.0964936153062848 0.909344626000501 mirMAP -0.306877665867527 1.54416013145896e-05 NA NA NA hsa-miR-369-3p PRKCA 0.658307572343713 0.108939404101946 0.0964936153062848 0.909344626000501 PITA;miRNATAP -0.20304365386022 7.15872061032479e-05 NA NA NA hsa-miR-374a-3p PRKCA 0.00444091189256923 0.997279477304268 0.0964936153062848 0.909344626000501 mirMAP -0.22267485671183 0.00358132021754311 NA NA NA hsa-miR-374a-5p PRKCA 0.280580933704653 0.711312203580958 0.0964936153062848 0.909344626000501 mirMAP -0.45703847123366 5.16876833886692e-06 NA NA NA hsa-miR-374b-5p PRKCA 0.00830204566239612 0.992518773949115 0.0964936153062848 0.909344626000501 mirMAP -0.168663297071887 0.026440933551222 NA NA NA hsa-miR-429 PRKCA 1.19781217693135 0.322310054579944 0.0964936153062848 0.909344626000501 miRanda;miRNATAP -0.101163619888014 8.80289322659118e-05 NA NA NA hsa-miR-450b-5p PRKCA 1.31989436603254 0.00773738577557236 0.0964936153062848 0.909344626000501 PITA;mirMAP;miRNATAP -0.124627316291886 0.00781299413580925 NA NA NA hsa-miR-452-5p PRKCA 0.554766385459708 0.461430383959838 0.0964936153062848 0.909344626000501 mirMAP -0.105992840145472 0.0116170722415173 NA NA NA hsa-miR-495-3p PRKCA -0.0502636491763475 0.910413613991017 0.0964936153062848 0.909344626000501 mirMAP -0.105797660090786 0.0464974022121671 NA NA NA hsa-miR-505-3p PRKCA 0.562949148550054 0.467734180580651 0.0964936153062848 0.909344626000501 miRNAWalker2_validate -0.163001973704478 0.000242217094394213 NA NA NA hsa-miR-550a-3p PRKCA 0.396845796562512 0.319546708346469 0.0964936153062848 0.909344626000501 miRNATAP -0.131602303065082 0.000180638909544589 NA NA NA hsa-miR-590-3p PRKCA 0.750834112502691 0.0721409718537464 0.0964936153062848 0.909344626000501 PITA;miRanda;mirMAP;miRNATAP -0.249847263946731 1.19260552473751e-08 NA NA NA hsa-miR-654-3p PRKCA -0.159408393093276 0.803524098022073 0.0964936153062848 0.909344626000501 mirMAP -0.124205811492343 0.00427402321719794 NA NA NA hsa-miR-92a-3p PRKCA 0.944279015811086 0.614191641461169 0.0964936153062848 0.909344626000501 miRNAWalker2_validate -0.105794669496435 0.0368971322526323 NA NA NA hsa-miR-93-3p PRKCA 1.0379867963088 0.0605530010506672 0.0964936153062848 0.909344626000501 mirMAP -0.101897966213245 0.012438491699105 NA NA NA hsa-miR-141-5p PRKCB 1.80215279308671 0.171717196416484 -0.968567174895964 0.104158738307402 mirMAP -0.533489005918096 8.96424723395829e-24 NA NA NA hsa-miR-146a-5p PRKCB 0.67061946633831 0.538820409992621 -0.968567174895964 0.104158738307402 mirMAP -0.152127637834003 0.0259729793981205 NA NA NA hsa-miR-146b-5p PRKCB 2.36576014745762 0.0657344824311623 -0.968567174895964 0.104158738307402 mirMAP -0.153760705978047 0.0498603039744559 NA NA NA hsa-miR-148a-5p PRKCB -0.0671657147202627 0.935632562211656 -0.968567174895964 0.104158738307402 mirMAP -0.223097361213222 0.0029995956938568 NA NA NA hsa-miR-16-2-3p PRKCB 0.73180598347188 0.153070057533699 -0.968567174895964 0.104158738307402 mirMAP -0.436052760015684 1.00896402706356e-09 NA NA NA hsa-miR-186-5p PRKCB 0.273626466122302 0.807169118774403 -0.968567174895964 0.104158738307402 mirMAP -0.646334467271288 2.25353092064729e-07 NA NA NA hsa-miR-194-5p PRKCB 1.98051780248547 0.297931251695511 -0.968567174895964 0.104158738307402 miRNATAP -0.323196162493343 3.81053633148988e-10 NA NA NA hsa-miR-200b-3p PRKCB 1.76966404687048 0.251078084855527 -0.968567174895964 0.104158738307402 MirTarget -0.497565132044805 1.71366823187318e-21 NA NA NA hsa-miR-200c-3p PRKCB 1.38059869033872 0.459075461573504 -0.968567174895964 0.104158738307402 MirTarget;miRNATAP -0.586559792974007 1.392370348599e-28 NA NA NA hsa-miR-23a-3p PRKCB 0.727812777693753 0.65239699793942 -0.968567174895964 0.104158738307402 mirMAP -0.876733286114987 1.06301530396503e-07 NA NA NA hsa-miR-24-3p PRKCB 0.354839860104953 0.813951308530073 -0.968567174895964 0.104158738307402 miRNATAP -0.999369854861052 9.62624180991222e-13 NA NA NA hsa-miR-26b-5p PRKCB -0.640970973524183 0.623642285963207 -0.968567174895964 0.104158738307402 mirMAP -0.227583712979924 0.018820598859962 NA NA NA hsa-miR-27a-3p PRKCB 0.505339123854064 0.734502884016765 -0.968567174895964 0.104158738307402 MirTarget;miRNATAP -0.856142305461551 5.43109464057364e-10 NA NA NA hsa-miR-29a-5p PRKCB 0.868963854135301 0.0539172641542065 -0.968567174895964 0.104158738307402 mirMAP -0.435258211064732 2.97459700617022e-06 NA NA NA hsa-miR-29b-1-5p PRKCB 1.09679805967173 0.0180205129273663 -0.968567174895964 0.104158738307402 mirMAP -0.307390445589517 1.04551286529139e-06 NA NA NA hsa-miR-30b-5p PRKCB -0.124247247359659 0.917685196303453 -0.968567174895964 0.104158738307402 mirMAP -0.269771353945051 0.00829712495465687 NA NA NA hsa-miR-30d-3p PRKCB -0.0804985653060761 0.825203889451817 -0.968567174895964 0.104158738307402 mirMAP -0.445674096411341 0.000174052423367113 NA NA NA hsa-miR-30d-5p PRKCB 0.218119609086939 0.898751473051369 -0.968567174895964 0.104158738307402 mirMAP -0.915098072019165 1.87121638730407e-08 NA NA NA hsa-miR-326 PRKCB -0.686277598234758 0.130157755184283 -0.968567174895964 0.104158738307402 miRanda;miRNATAP -0.17347564191226 0.0152726461858765 NA NA NA hsa-miR-330-5p PRKCB 0.522359698833297 0.46945472961169 -0.968567174895964 0.104158738307402 miRanda -0.509819843160937 2.59506167562722e-08 NA NA NA hsa-miR-335-3p PRKCB 2.25543430538924 0.0139006907758541 -0.968567174895964 0.104158738307402 mirMAP -0.543040838922981 1.64126163527148e-17 NA NA NA hsa-miR-335-5p PRKCB 0.484676450705085 0.267046535449854 -0.968567174895964 0.104158738307402 mirMAP -0.424463414573891 2.91570441477798e-08 NA NA NA hsa-miR-3607-3p PRKCB 0.402426470225138 0.613303667114625 -0.968567174895964 0.104158738307402 miRNATAP -0.140661204294696 0.00277753801805089 NA NA NA hsa-miR-361-5p PRKCB 0.517068298358111 0.640548482802509 -0.968567174895964 0.104158738307402 MirTarget;miRanda;miRNATAP -0.951027967173753 3.03486822731836e-07 NA NA NA hsa-miR-409-3p PRKCB 1.06826077189128 0.086796304502529 -0.968567174895964 0.104158738307402 mirMAP -0.385704678138501 0.000184630441950642 NA NA NA hsa-miR-429 PRKCB 1.19781217693135 0.322310054579944 -0.968567174895964 0.104158738307402 MirTarget;miRanda;miRNATAP -0.412190991694485 3.05010466497273e-19 NA NA NA hsa-miR-450b-5p PRKCB 1.31989436603254 0.00773738577557236 -0.968567174895964 0.104158738307402 miRNATAP -0.379715627717053 1.48587331724702e-05 NA NA NA hsa-miR-484 PRKCB 0.340101271888636 0.69389289011036 -0.968567174895964 0.104158738307402 MirTarget;miRNATAP -0.39881779496348 1.86595845940554e-05 NA NA NA hsa-miR-502-5p PRKCB 0.799178521682916 0.00801502500527688 -0.968567174895964 0.104158738307402 mirMAP -0.33518194305493 3.85635163129591e-05 NA NA NA hsa-miR-539-5p PRKCB 0.52442930819186 0.252147293315543 -0.968567174895964 0.104158738307402 mirMAP -0.145579402563367 0.0345058056541018 NA NA NA hsa-miR-589-3p PRKCB 0.91523747397743 0.0032660296472646 -0.968567174895964 0.104158738307402 mirMAP -0.492990440963876 8.56198440689939e-11 NA NA NA hsa-miR-589-5p PRKCB 1.1821804664823 0.162299570206384 -0.968567174895964 0.104158738307402 mirMAP -0.707388712768361 1.3560400508873e-10 NA NA NA hsa-miR-590-3p PRKCB 0.750834112502691 0.0721409718537464 -0.968567174895964 0.104158738307402 mirMAP -0.470974962365616 1.36331162559742e-08 NA NA NA hsa-miR-590-5p PRKCB 0.763126350124264 0.184296330120049 -0.968567174895964 0.104158738307402 miRanda -0.48467332557162 4.64155807201668e-10 NA NA NA hsa-miR-7-1-3p PRKCB 0.642828512342857 0.399017154673609 -0.968567174895964 0.104158738307402 mirMAP -0.553080614655878 3.799357220355e-13 NA NA NA hsa-miR-7-5p PRKCB 1.10068930642027 0.0314621365860381 -0.968567174895964 0.104158738307402 MirTarget;miRNATAP -0.451555218301338 2.85896004915139e-13 NA NA NA hsa-miR-486-5p PRKCG -1.48301218922372 0.0956207127449173 3.0487170881214 3.29831139930448e-09 miRanda -0.277490995076235 0.0135429264780433 NA NA NA hsa-miR-129-5p PRKX -1.43651546966112 0.00183085217431586 1.04642263577372 0.126137820937772 miRanda;mirMAP -0.133604093083896 1.27028880336466e-05 NA NA NA hsa-miR-139-5p PRKX -1.31022051532559 0.0657735573826271 1.04642263577372 0.126137820937772 MirTarget -0.226299604765045 4.42232547711776e-05 NA NA NA hsa-miR-143-5p PRKX -0.397766604276963 0.675429810432737 1.04642263577372 0.126137820937772 miRNATAP -0.128444524848598 0.00261077992482386 NA NA NA hsa-miR-145-5p PRKX -1.40800249480536 0.387661708271684 1.04642263577372 0.126137820937772 MirTarget;miRNATAP -0.277261417692981 2.01589373095567e-12 NA NA NA hsa-miR-195-3p PRKX -0.522236286339218 0.0566853778570702 1.04642263577372 0.126137820937772 MirTarget;mirMAP -0.205719658254992 0.000396084127536688 NA NA NA hsa-miR-218-5p PRKX -0.401334252515531 0.54877923107825 1.04642263577372 0.126137820937772 miRNATAP -0.18138947195693 0.000314019565228614 NA NA NA hsa-miR-29c-3p PRKX -1.25061656348357 0.418526829407785 1.04642263577372 0.126137820937772 mirMAP -0.167947864092973 0.00224374802228136 NA NA NA hsa-miR-101-3p RAC1 0.00372620325665807 0.998376926598058 0.000784664144720892 0.999467502496042 miRNAWalker2_validate;MirTarget -0.122714106193022 0.0166720274242453 25202416;24649082;25057058 In previous studies the role of miRNA-101 miR-101 in tumors has been identified as a tumor suppressor and until now the role of miR-101 and Rac1 in thyroid cancer has remained undefined; Rac1 was demonstrated to be negatively regulated by miR-101 at the post-transcriptional level via a specific target site within the 3' untranslated region by dual-luciferase reporter assay; The expression of Rac1 was also observed to inversely correlate with miR-101 expression in PTC tissues; knockdown of Rac1 by shRNA inhibited thyroid cancer cell migration and invasion resembling that of miR-101 overexpression; Thus these findings suggested that miR-101 acts as a novel suppressor by targeting the Rac1 gene and inhibiting thyroid cancer cell migration and invasion;miR 101 inhibits cell proliferation by targeting Rac1 in papillary thyroid carcinoma; In the present study we investigated the role of microRNA-101 miR-101 in PTC via targeting of Ras-related C3 botulinum toxin substrate 1 Rac1; Moreover algorithm-based and experimental strategies verified Rac1 as a direct target of miR-101 in the K1 cell line; Taken together these findings suggest that miR-101 inhibited PTC growth via the downregulation of Rac1 expression providing a better understanding of miRNA-modulated signaling networks for future cancer therapeutics;Mir-101 inhibitors significantly increased the luciferase activities of RAC1 3'UTR; Overexpression of mir-101 increased the expression of RAC1 while inhibition of mir-101 suppressed RAC1 expression; mir-101 can suppress RAC1 gene expression by targeting the specific sequence of RAC1 3'UTR cell migration;; thyroid cancer;thyroid cancer;colorectal cancer hsa-miR-30c-2-3p RAC3 -0.730753355528392 0.223048822447852 0.200091539937742 0.627900081789961 miRNAWalker2_validate -0.201786475705859 0.0125232109923408 NA NA NA hsa-miR-361-5p RHOA 0.517068298358111 0.640548482802509 -0.388675530800876 0.754491223111561 MirTarget;PITA;miRanda -0.153366711913578 0.000800577986068044 NA NA NA hsa-let-7a-3p ROCK1 0.180588894055192 0.807497649839616 0.270578657867548 0.757304762354249 MirTarget -0.293538486864222 1.79458434172464e-16 NA NA NA hsa-let-7b-3p ROCK1 0.273132474559554 0.682533246372485 0.270578657867548 0.757304762354249 MirTarget -0.399550423810867 1.18067958104817e-16 NA NA NA hsa-let-7f-1-3p ROCK1 1.02975898416111 0.00216616040865014 0.270578657867548 0.757304762354249 MirTarget -0.265521222949485 1.02167527842417e-12 NA NA NA hsa-let-7g-3p ROCK1 0.692324017258497 0.345964739358737 0.270578657867548 0.757304762354249 MirTarget -0.172489745632955 4.30723627056579e-16 NA NA NA hsa-miR-126-5p ROCK1 0.393018523145496 0.713269992183763 0.270578657867548 0.757304762354249 mirMAP -0.328906433159776 3.05319022728471e-19 27108693 MicroRNA 126 inhibits tumor cell invasion and metastasis by downregulating ROCK1 in renal cell carcinoma metastasis kidney renal cell cancer hsa-miR-142-5p ROCK1 1.06109968632125 0.257318725443238 0.270578657867548 0.757304762354249 PITA;mirMAP -0.207742850324027 4.15447630693299e-20 NA NA NA hsa-miR-144-3p ROCK1 -1.35523948089606 0.00271266747925526 0.270578657867548 0.757304762354249 MirTarget -0.133224665456045 1.37943628678701e-11 25912304 Furthermore we identified Rho-associated kinases 1 and 2 ROCK1 and ROCK2 as direct targets for miR-144 binding resulting in suppression of their expression; In clinical OS specimens ROCK1 and ROCK2 levels were elevated relative to that in paired normal bone tissues and inversely correlated with miR-144 expression; Taken together miR-144 suppresses OS progression by directly downregulating ROCK1 and ROCK2 expression and may be a promising therapeutic target for OS progression sarcoma hsa-miR-146a-5p ROCK1 0.67061946633831 0.538820409992621 0.270578657867548 0.757304762354249 miRNAWalker2_validate;miRTarBase -0.126899444900952 1.74206572320051e-07 26306811;18174313 In mechanic analyses we found that miR-146a inhibited the basal level of Rho-associated coiled-coil containing protein kinase 1 ROCK1 expression by targeting its 3'UTR and an inverse correlation of expression between miR-146a and ROCK1 was observed;Transfection of mir-146a which perpetually express the miRNA suppressed >82% of the expression of the targeted protein-coding gene ROCK1 in androgen-independent PC3 cells consequently markedly reducing cell proliferation invasion and metastasis to human bone marrow endothelial cell monolayers; Given that ROCK1 is one of the key kinases for the activation of hyaluronan HA-mediated HRPC transformation in vivo and in PC3 cells mir-146a may function as a tumor-suppressor gene in modulating HA/ROCK1-mediated tumorigenecity in androgen-dependent prostate cancer ;metastasis prostate cancer;prostate cancer hsa-miR-148b-3p ROCK1 0.686272171036606 0.498004854065858 0.270578657867548 0.757304762354249 miRNAWalker2_validate -0.283992504089423 8.1691029380259e-14 NA NA NA hsa-miR-182-5p ROCK1 1.43665900078936 0.443507432581923 0.270578657867548 0.757304762354249 MirTarget -0.145654717864713 2.55003138079812e-11 NA NA NA hsa-miR-190a-5p ROCK1 -0.121498535316968 0.767260995540885 0.270578657867548 0.757304762354249 MirTarget -0.132775661402919 0.000182792251894966 NA NA NA hsa-miR-320a ROCK1 0.22287875340213 0.865731646872282 0.270578657867548 0.757304762354249 miRanda -0.148396403760454 0.000223848256114339 NA NA NA hsa-miR-320b ROCK1 0.941267876385794 0.0453505938355543 0.270578657867548 0.757304762354249 miRanda -0.179568323806299 1.72876442109942e-11 NA NA NA hsa-miR-324-5p ROCK1 0.707588389659175 0.29394916610875 0.270578657867548 0.757304762354249 MirTarget;PITA;miRanda -0.164810436553586 2.39164537877702e-09 NA NA NA hsa-miR-326 ROCK1 -0.686277598234758 0.130157755184283 0.270578657867548 0.757304762354249 miRanda -0.215532081164493 6.49119442378062e-19 NA NA NA hsa-miR-330-3p ROCK1 0.237023779714759 0.466174401969581 0.270578657867548 0.757304762354249 PITA -0.182259575154588 1.06458305621195e-07 NA NA NA hsa-miR-335-5p ROCK1 0.484676450705085 0.267046535449854 0.270578657867548 0.757304762354249 MirTarget -0.118902868142428 2.3560346190715e-05 25804796;23975506;27035227 MiR 335 acts as a potential tumor suppressor miRNA via downregulating ROCK1 expression in hepatocellular carcinoma; Luciferase reporter assay and Western blot were to verify ROCK1 as a novel target gene of miR-335; The expression of ROCK1 was decreased evidently after overexpression of miR-335 indicating that ROCK1 is a target gene for miR-335; Our data revealed that miR-335 could inhibit the proliferation and migration invasion of HCC cells via regulating ROCK1 suggesting that miR-335 could be a therapeutic biomarker of HCC in the future;miR 335 suppresses migration and invasion by targeting ROCK1 in osteosarcoma cells; Moreover we also showed that ROCK1 was negatively regulated by miR-335 at the posttranscriptional level via a specific target site within the 3'UTR by luciferase reporter assay; Thus our findings suggest that miR-335 acts as tumor suppressor by targeting the ROCK1 gene and inhibiting osteosarcoma cells migration and invasion;MicroRNA 335 is downregulated in bladder cancer and inhibits cell growth migration and invasion via targeting ROCK1 ;; liver cancer;sarcoma;bladder cancer hsa-miR-429 ROCK1 1.19781217693135 0.322310054579944 0.270578657867548 0.757304762354249 miRanda -0.110680901030252 1.58976408573796e-10 NA NA NA hsa-miR-511-5p ROCK1 0.743122530026616 0.141222906192463 0.270578657867548 0.757304762354249 MirTarget -0.182869446223698 3.20641697631426e-12 NA NA NA hsa-miR-582-5p ROCK1 -0.0750818699965312 0.895875799292592 0.270578657867548 0.757304762354249 PITA -0.129677614397133 0.000108580013073092 NA NA NA hsa-let-7a-3p ROCK2 0.180588894055192 0.807497649839616 0.3917872138114 0.633636262909752 mirMAP -0.245379357038312 1.14404853659964e-09 NA NA NA hsa-let-7b-3p ROCK2 0.273132474559554 0.682533246372485 0.3917872138114 0.633636262909752 mirMAP -0.203656982268114 0.000262549586361423 NA NA NA hsa-miR-126-5p ROCK2 0.393018523145496 0.713269992183763 0.3917872138114 0.633636262909752 mirMAP -0.222480202502808 1.4681178919308e-07 NA NA NA hsa-miR-127-5p ROCK2 0.831883513783777 0.426576346713077 0.3917872138114 0.633636262909752 PITA -0.127342604952303 0.000268867212011194 NA NA NA hsa-miR-142-5p ROCK2 1.06109968632125 0.257318725443238 0.3917872138114 0.633636262909752 PITA -0.166076316228658 1.3524619640517e-10 NA NA NA hsa-miR-369-3p ROCK2 0.658307572343713 0.108939404101946 0.3917872138114 0.633636262909752 PITA -0.110986856296274 0.00431783337545537 NA NA NA hsa-miR-590-3p ROCK2 0.750834112502691 0.0721409718537464 0.3917872138114 0.633636262909752 miRanda;mirMAP -0.177382603974741 9.28492401005653e-08 NA NA NA hsa-miR-1301-3p SFRP1 1.64520910263944 0.000545071150079123 -3.09500688877524 2.34623001047302e-07 MirTarget -0.947146076050491 1.5596785757464e-14 NA NA NA hsa-miR-144-3p SFRP1 -1.35523948089606 0.00271266747925526 -3.09500688877524 2.34623001047302e-07 MirTarget;miRNATAP -0.273517067691959 0.00452342635032899 NA NA NA hsa-miR-146a-5p SFRP1 0.67061946633831 0.538820409992621 -3.09500688877524 2.34623001047302e-07 MirTarget -0.949791171229486 4.74722974148745e-18 NA NA NA hsa-miR-146b-5p SFRP1 2.36576014745762 0.0657344824311623 -3.09500688877524 2.34623001047302e-07 MirTarget -0.930827594577234 4.06992890317546e-13 NA NA NA hsa-miR-16-1-3p SFRP1 1.19610046660482 0.002811511491851 -3.09500688877524 2.34623001047302e-07 MirTarget -1.50038443338432 6.77575531624944e-28 NA NA NA hsa-miR-182-5p SFRP1 1.43665900078936 0.443507432581923 -3.09500688877524 2.34623001047302e-07 mirMAP -1.11955718404861 2.48442142768689e-32 NA NA NA hsa-miR-192-3p SFRP1 1.53303749871781 0.126158902379712 -3.09500688877524 2.34623001047302e-07 MirTarget -0.674704415747331 1.08172903813383e-17 NA NA NA hsa-miR-19b-1-5p SFRP1 1.68690066069614 0.001519169322997 -3.09500688877524 2.34623001047302e-07 MirTarget -1.46372721330681 1.58547711479536e-34 NA NA NA hsa-miR-203a-3p SFRP1 0.611075025115978 0.739204964576711 -3.09500688877524 2.34623001047302e-07 MirTarget -0.704662901196834 1.62533115747839e-18 NA NA NA hsa-miR-26b-3p SFRP1 0.189972507055099 0.7740623413589 -3.09500688877524 2.34623001047302e-07 MirTarget -0.711293491808491 2.15679328121234e-09 NA NA NA hsa-miR-27a-3p SFRP1 0.505339123854064 0.734502884016765 -3.09500688877524 2.34623001047302e-07 MirTarget;miRNATAP -1.80048879640444 7.62440295710228e-15 NA NA NA hsa-miR-29a-5p SFRP1 0.868963854135301 0.0539172641542065 -3.09500688877524 2.34623001047302e-07 mirMAP -1.2917730471005 2.30417433342081e-17 NA NA NA hsa-miR-30d-3p SFRP1 -0.0804985653060761 0.825203889451817 -3.09500688877524 2.34623001047302e-07 miRNATAP -1.10953212692239 3.01205057064979e-08 NA NA NA hsa-miR-335-5p SFRP1 0.484676450705085 0.267046535449854 -3.09500688877524 2.34623001047302e-07 miRNAWalker2_validate -0.603908472377432 5.03550466980235e-06 NA NA NA hsa-miR-33a-3p SFRP1 -0.0493858782224366 0.86469054162599 -3.09500688877524 2.34623001047302e-07 MirTarget -0.962911142693324 2.97549627473371e-12 NA NA NA hsa-miR-429 SFRP1 1.19781217693135 0.322310054579944 -3.09500688877524 2.34623001047302e-07 miRNATAP -0.766085113131241 5.13734355762499e-23 NA NA NA hsa-miR-484 SFRP1 0.340101271888636 0.69389289011036 -3.09500688877524 2.34623001047302e-07 MirTarget -1.24008251648115 4.7011099843482e-16 NA NA NA hsa-miR-501-5p SFRP1 1.51510872844603 0.000249681492153084 -3.09500688877524 2.34623001047302e-07 mirMAP -1.11406529303042 8.63262655758483e-22 NA NA NA hsa-miR-542-3p SFRP1 1.09096556479387 0.289651874996689 -3.09500688877524 2.34623001047302e-07 MirTarget;miRanda -0.799203896319953 6.19766150981851e-05 NA NA NA hsa-miR-576-5p SFRP1 0.744407899578399 0.146981973135162 -3.09500688877524 2.34623001047302e-07 MirTarget;PITA -1.45743399098795 1.5808129859835e-26 NA NA NA hsa-miR-625-5p SFRP1 0.51369754623655 0.274843890626581 -3.09500688877524 2.34623001047302e-07 MirTarget -1.11141317021754 4.74397592258059e-25 NA NA NA hsa-miR-7-1-3p SFRP1 0.642828512342857 0.399017154673609 -3.09500688877524 2.34623001047302e-07 MirTarget;mirMAP -1.32597895099845 5.52059480156843e-27 NA NA NA hsa-miR-940 SFRP1 1.13111289289361 0.0032414719740783 -3.09500688877524 2.34623001047302e-07 MirTarget -0.723311778807967 3.92433148794599e-12 NA NA NA hsa-miR-96-5p SFRP1 1.14766037573765 0.0779994051337465 -3.09500688877524 2.34623001047302e-07 mirMAP -1.09215928872365 3.34832863223219e-30 NA NA NA hsa-let-7a-3p SFRP2 0.180588894055192 0.807497649839616 0.600535768348692 0.521208040881389 miRNATAP -0.665717599435588 0.000157727652573802 NA NA NA hsa-let-7b-3p SFRP2 0.273132474559554 0.682533246372485 0.600535768348692 0.521208040881389 miRNATAP -0.735466245182302 0.00214760709862247 NA NA NA hsa-miR-29a-3p SFRP2 -0.289266265366038 0.873126628905318 0.600535768348692 0.521208040881389 miRNAWalker2_validate;miRTarBase -0.657010004267408 0.00159748715606187 NA NA NA hsa-miR-33a-3p SFRP2 -0.0493858782224366 0.86469054162599 0.600535768348692 0.521208040881389 miRNATAP -0.806298409788689 7.42679792501908e-09 NA NA NA hsa-miR-421 SFRP2 1.28183445098144 3.9841687793795e-06 0.600535768348692 0.521208040881389 miRanda -0.632886108916327 6.63868368249471e-06 NA NA NA hsa-miR-450b-5p SFRP2 1.31989436603254 0.00773738577557236 0.600535768348692 0.521208040881389 PITA;miRNATAP -0.298106953131752 0.049602476130364 27494869 Furthermore we demonstrated that miR-450b-5p directly bound the 3'-UTRs of SFRP2 and SIAH1 and activated Wnt/β-Catenin signaling colorectal cancer hsa-miR-455-5p SFRP2 0.610591180666197 0.405984831720842 0.600535768348692 0.521208040881389 miRanda -1.1060282270764 2.7137343417582e-14 NA NA NA hsa-miR-582-5p SFRP2 -0.0750818699965312 0.895875799292592 0.600535768348692 0.521208040881389 miRNATAP -0.339947535166717 0.0326606171535302 NA NA NA hsa-miR-590-3p SFRP2 0.750834112502691 0.0721409718537464 0.600535768348692 0.521208040881389 miRanda -0.847425136332515 1.91807514073649e-09 NA NA NA hsa-miR-144-5p SFRP4 -1.31041623056934 0.122751386505603 4.12551703324504 4.39989547221855e-06 MirTarget -0.967665579090963 2.2168346751568e-17 NA NA NA hsa-miR-26b-5p SFRP4 -0.640970973524183 0.623642285963207 4.12551703324504 4.39989547221855e-06 miRNAWalker2_validate -0.952194733414776 8.52358403720414e-09 NA NA NA hsa-miR-375 SFRP4 -0.788117484318985 0.686238069325285 4.12551703324504 4.39989547221855e-06 miRanda -0.286617304932478 2.20492738655522e-05 NA NA NA hsa-miR-429 SFRP4 1.19781217693135 0.322310054579944 4.12551703324504 4.39989547221855e-06 miRanda -0.445393777606902 1.3708977111934e-07 NA NA NA hsa-miR-532-5p SFRP4 1.37200327675848 0.338407542476233 4.12551703324504 4.39989547221855e-06 MirTarget -0.599125475767995 0.000360185968095883 NA NA NA hsa-miR-664a-3p SFRP4 -0.0286436952305813 0.961537804671418 4.12551703324504 4.39989547221855e-06 mirMAP -0.626641853200205 0.00674035942716111 NA NA NA hsa-miR-146b-5p SFRP5 2.36576014745762 0.0657344824311623 -2.84785167177623 2.6717518512746e-06 miRanda -0.785173092843259 2.08947641911538e-08 NA NA NA hsa-miR-140-5p SIAH1 0.0863677120902411 0.909387194440856 -0.0711519910642711 0.911119094212458 PITA;miRanda;miRNATAP -0.106942874491873 6.04854133472434e-06 NA NA NA hsa-miR-15b-5p SIAH1 0.441873888832829 0.683456288766732 -0.0711519910642711 0.911119094212458 miRNATAP -0.109721355051037 9.70356878378267e-07 NA NA NA hsa-miR-16-5p SIAH1 0.294875982844909 0.811640142720194 -0.0711519910642711 0.911119094212458 miRNATAP -0.122655937983167 2.99039931302322e-10 NA NA NA hsa-miR-107 SKP1 0.808649908398562 0.357609254490153 -0.574181386048053 0.5518239439623 miRanda -0.275025859253799 4.0938047584375e-11 NA NA NA hsa-miR-1301-3p SKP1 1.64520910263944 0.000545071150079123 -0.574181386048053 0.5518239439623 miRNAWalker2_validate -0.113976279902926 9.0932729820053e-08 NA NA NA hsa-miR-130b-3p SKP1 1.118725142912 0.0736094039162448 -0.574181386048053 0.5518239439623 MirTarget -0.105055541224109 7.95433236976247e-08 NA NA NA hsa-miR-148b-3p SKP1 0.686272171036606 0.498004854065858 -0.574181386048053 0.5518239439623 MirTarget -0.190410121787295 5.33656301758751e-10 NA NA NA hsa-miR-151a-5p SKP1 0.733709756803425 0.408965276134793 -0.574181386048053 0.5518239439623 miRNAWalker2_validate -0.106048458821012 0.000121282748684527 NA NA NA hsa-miR-222-3p SKP1 1.39835693864931 0.143802388795275 -0.574181386048053 0.5518239439623 MirTarget -0.112572088074134 8.85288250595293e-08 NA NA NA hsa-miR-3913-5p SKP1 1.08617284012911 2.6412048074514e-06 -0.574181386048053 0.5518239439623 MirTarget -0.143926192435663 3.61388521990899e-06 NA NA NA hsa-miR-450b-5p SKP1 1.31989436603254 0.00773738577557236 -0.574181386048053 0.5518239439623 miRNATAP -0.123096762313139 9.75972625687943e-07 NA NA NA hsa-miR-7-1-3p SKP1 0.642828512342857 0.399017154673609 -0.574181386048053 0.5518239439623 MirTarget;mirMAP -0.104933318731799 3.39509150742036e-06 NA NA NA hsa-let-7a-3p SMAD2 0.180588894055192 0.807497649839616 -0.120121076537491 0.883833666409986 mirMAP -0.106101759255441 0.000100303444197151 NA NA NA hsa-let-7b-3p SMAD2 0.273132474559554 0.682533246372485 -0.120121076537491 0.883833666409986 mirMAP -0.11319020038656 0.00230362474156071 NA NA NA hsa-let-7f-1-3p SMAD2 1.02975898416111 0.00216616040865014 -0.120121076537491 0.883833666409986 mirMAP -0.100461508135326 0.000354947451412854 NA NA NA hsa-miR-106b-5p SMAD2 0.947523403196215 0.405863421831729 -0.120121076537491 0.883833666409986 mirMAP -0.109902235320899 3.28668167656852e-05 NA NA NA hsa-miR-142-5p SMAD2 1.06109968632125 0.257318725443238 -0.120121076537491 0.883833666409986 mirMAP;miRNATAP -0.110568024743433 1.1149349680788e-10 NA NA NA hsa-miR-148b-3p SMAD2 0.686272171036606 0.498004854065858 -0.120121076537491 0.883833666409986 MirTarget;mirMAP -0.136810269145914 1.68238174009693e-06 NA NA NA hsa-miR-155-5p SMAD2 0.689059012865632 0.586621132607867 -0.120121076537491 0.883833666409986 miRNAWalker2_validate;miRTarBase;MirTarget;mirMAP -0.104705142933411 2.71595551370121e-08 22426647;25283513 Taken together these data suggest that miR-155 may function as a tumor suppressor to regulate gastric cancer cell metastasis by targeting SMAD2 and its downregulation in gastric cancer cells may be partly ascribed to DNA methylation;MiR-155 which targeted the SMAD2-3'UTR decreased the expression and function of SMAD2 metastasis; gastric cancer;prostate cancer hsa-miR-186-5p SMAD2 0.273626466122302 0.807169118774403 -0.120121076537491 0.883833666409986 mirMAP -0.10283948247702 0.00219201376868083 NA NA NA hsa-miR-212-3p SMAD2 0.895869490569324 0.0316777138361649 -0.120121076537491 0.883833666409986 MirTarget -0.122412590328633 2.58758943180455e-05 NA NA NA hsa-miR-26a-5p SMAD2 -0.459645668105514 0.761702789258103 -0.120121076537491 0.883833666409986 mirMAP -0.174225805102639 2.7315030695384e-05 NA NA NA hsa-miR-26b-5p SMAD2 -0.640970973524183 0.623642285963207 -0.120121076537491 0.883833666409986 mirMAP -0.100120618576573 8.03405526518063e-05 NA NA NA hsa-miR-30e-3p SMAD2 -0.528630634076661 0.752496184625955 -0.120121076537491 0.883833666409986 mirMAP -0.110736123708528 0.00578441961666557 NA NA NA hsa-miR-361-3p SMAD2 0.480275847363033 0.635924490895616 -0.120121076537491 0.883833666409986 miRNATAP -0.108649584013497 0.00216027730733127 22675530 Functional analyses showed that Smad2 and TGFß1 are not dysregulated by miR-361-3p and miR-625* in the lung cell line A549 respectively lung cancer hsa-miR-3613-5p SMAD2 0.888536545073334 0.0940415939776757 -0.120121076537491 0.883833666409986 mirMAP -0.113531996044768 9.60967230032425e-09 NA NA NA hsa-miR-374a-5p SMAD2 0.280580933704653 0.711312203580958 -0.120121076537491 0.883833666409986 MirTarget -0.149326836629435 0.00327268419601322 NA NA NA hsa-miR-374b-5p SMAD2 0.00830204566239612 0.992518773949115 -0.120121076537491 0.883833666409986 MirTarget -0.156419618593836 3.17442052120825e-05 NA NA NA hsa-miR-450b-5p SMAD2 1.31989436603254 0.00773738577557236 -0.120121076537491 0.883833666409986 mirMAP -0.10159272893609 1.17889003663917e-05 NA NA NA hsa-miR-455-5p SMAD2 0.610591180666197 0.405984831720842 -0.120121076537491 0.883833666409986 miRanda -0.101824890946511 1.28998280388769e-05 NA NA NA hsa-miR-484 SMAD2 0.340101271888636 0.69389289011036 -0.120121076537491 0.883833666409986 miRNAWalker2_validate -0.12218203276992 6.12708677691158e-07 NA NA NA hsa-miR-542-3p SMAD2 1.09096556479387 0.289651874996689 -0.120121076537491 0.883833666409986 PITA -0.11939429643036 0.000108480960132617 NA NA NA hsa-miR-590-3p SMAD2 0.750834112502691 0.0721409718537464 -0.120121076537491 0.883833666409986 MirTarget;PITA;mirMAP;miRNATAP -0.10601759948264 1.67499305640438e-06 NA NA NA hsa-let-7a-3p SMAD4 0.180588894055192 0.807497649839616 -0.290880750164782 0.720889676191258 mirMAP -0.158754110657301 8.82154754138378e-06 NA NA NA hsa-let-7b-3p SMAD4 0.273132474559554 0.682533246372485 -0.290880750164782 0.720889676191258 mirMAP -0.149167029513993 0.00225841088076548 NA NA NA hsa-let-7f-1-3p SMAD4 1.02975898416111 0.00216616040865014 -0.290880750164782 0.720889676191258 mirMAP -0.166570671732699 5.74927260212123e-06 NA NA NA hsa-miR-106b-5p SMAD4 0.947523403196215 0.405863421831729 -0.290880750164782 0.720889676191258 mirMAP;miRNATAP -0.184533736765317 8.39518666522128e-08 NA NA NA hsa-miR-10b-3p SMAD4 0.360517031366521 0.325264998344862 -0.290880750164782 0.720889676191258 miRNATAP -0.159407724307957 6.79848993859667e-05 NA NA NA hsa-miR-125a-3p SMAD4 0.149355443004115 0.640969561382793 -0.290880750164782 0.720889676191258 MirTarget;PITA;miRanda -0.115735289470815 0.000229466269924128 NA NA NA hsa-miR-126-5p SMAD4 0.393018523145496 0.713269992183763 -0.290880750164782 0.720889676191258 mirMAP -0.178764449211864 1.40878157147875e-06 NA NA NA hsa-miR-130a-3p SMAD4 0.410890280285832 0.607447245204235 -0.290880750164782 0.720889676191258 miRNAWalker2_validate;miRNATAP -0.113149137574814 0.000735997420311438 NA NA NA hsa-miR-130b-3p SMAD4 1.118725142912 0.0736094039162448 -0.290880750164782 0.720889676191258 miRNAWalker2_validate;miRNATAP -0.139975983216462 2.52861296124715e-09 NA NA NA hsa-miR-140-5p SMAD4 0.0863677120902411 0.909387194440856 -0.290880750164782 0.720889676191258 miRanda -0.132838174744716 0.000405083571693904 NA NA NA hsa-miR-142-5p SMAD4 1.06109968632125 0.257318725443238 -0.290880750164782 0.720889676191258 mirMAP -0.122968776338381 7.01570985560171e-08 NA NA NA hsa-miR-146a-5p SMAD4 0.67061946633831 0.538820409992621 -0.290880750164782 0.720889676191258 miRNAWalker2_validate;miRTarBase -0.11062787301315 2.24268345362731e-06 27438138;22020746;21982769 SMAD4 was identified as a miR-146a target and was downregulated in BARF1-expressing cells whereas SMAD4 expression was restored by anti-miR-146a; Knockdown of BARF1 in YCCEL1 cells upregulated SMAD4 and this effect was reversed by miR-146a overexpression; In stomach cancer tissues miR-146a was expressed at higher levels and more frequent NFκB nuclear positivity immunohistochemically but not of SMAD4 nuclear loss was found in the EBV-positive group compared with the EBV-negative group; In conclusion EBV-encoded BARF1 promotes cell proliferation in stomach cancer by upregulating NFκB and miR-146a and downregulating SMAD4 thereby contributing to EBV-induced stomach cancer progression;Increased miR 146a in gastric cancer directly targets SMAD4 and is involved in modulating cell proliferation and apoptosis; Using target prediction algorithms luciferase reporter assay and Western blot assay SMAD family member 4 SMAD4 was identified as a target gene of miR-146a in gastric cancer; Moreover an inverse correlation was observed between the expression of SMAD4 mRNA and miR-146a in gastric cancer tissues R=-0.731 P=0.039 Pearson's correlation; Taken together our results provide important evidence that miR-146a can directly target SMAD4 and suggest that miR-146a may play a role in the development of gastric cancer by modulating cell proliferation and apoptosis;The results indicated that miR-146a regulated the sensitivity of HCC cells to the cytotoxic effects of IFN-α through SMAD4 suggesting that this miRNA could be suitable for prediction of the clinical response and potential therapeutic target in HCC patients on IFN-based therapy progression;;drug resistance gastric cancer;gastric cancer;liver cancer hsa-miR-146b-5p SMAD4 2.36576014745762 0.0657344824311623 -0.290880750164782 0.720889676191258 PITA;miRanda;miRNATAP -0.107002098376942 7.30024432164399e-05 21874046;26883911 MicroRNA miR 146b 5p regulates signal transduction of TGF β by repressing SMAD4 in thyroid cancer; A computational search revealed that miR-146b-5p putatively binds to the 3' untranslated region UTR of SMAD4 an important member of the transforming growth factor β TGF-β signaling pathway; Luciferase reporter assay confirmed the direct binding of miR-146b-5p on the SMAD4 3'UTR; Specific inhibition of miR-146b-5p with a locked nucleic acid-modified anti-miR-146b oligonucleotide significantly increased SMAD4 levels in the human papillary carcinoma cell lines TPC-1 and BCPAP; The overexpression of miR-146b-5p in normal rat follicular PCCL3 cells decreased SMAD4 levels and disrupted TGF-β signal transduction;The overexpression of SMAD4 in BCPAP cells a validated target of miR-146b-5p and key protein in the TGF-β signaling pathway inhibited migration similarly to the effects observed with the antagomiR 146b-5p ; thyroid cancer;thyroid cancer hsa-miR-155-5p SMAD4 0.689059012865632 0.586621132607867 -0.290880750164782 0.720889676191258 miRNAWalker2_validate -0.110361346500155 1.04894256533641e-05 27626488 Here we demonstrated that TGF-β1 elevated the expression of miR-155 in colorectal cancer cells through SMAD3 and SMAD4 colorectal cancer hsa-miR-186-5p SMAD4 0.273626466122302 0.807169118774403 -0.290880750164782 0.720889676191258 miRNAWalker2_validate;mirMAP -0.142855340576068 0.00120323356560019 NA NA NA hsa-miR-18a-5p SMAD4 1.93049155460812 0.00663833971152871 -0.290880750164782 0.720889676191258 miRNAWalker2_validate -0.102223897399558 2.68354883367347e-06 NA NA NA hsa-miR-21-3p SMAD4 1.74562165194276 0.287275799258641 -0.290880750164782 0.720889676191258 mirMAP -0.141683159377289 2.21846815550061e-07 NA NA NA hsa-miR-2355-5p SMAD4 0.669289715474275 0.346698773665719 -0.290880750164782 0.720889676191258 MirTarget -0.145562327749666 0.000641834626866554 NA NA NA hsa-miR-25-3p SMAD4 0.850158516705894 0.641399047473048 -0.290880750164782 0.720889676191258 mirMAP -0.180794067126583 6.78771709744027e-06 NA NA NA hsa-miR-26a-5p SMAD4 -0.459645668105514 0.761702789258103 -0.290880750164782 0.720889676191258 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.144691235080344 0.00874593783404751 NA NA NA hsa-miR-26b-5p SMAD4 -0.640970973524183 0.623642285963207 -0.290880750164782 0.720889676191258 MirTarget;miRNATAP -0.115094993430442 0.000594240075621644 24890815 Overexpression of miR-26b also repressed Smad4 expression whereas its inhibition elevated Smad4 expression; In HCC cell lines miR-26b targeted the 3'UTR of USP9X which in turn affects EMT through Smad4 and the TGF-β signaling pathway liver cancer hsa-miR-27a-3p SMAD4 0.505339123854064 0.734502884016765 -0.290880750164782 0.720889676191258 MirTarget -0.230957844125686 2.14275721400976e-06 NA NA NA hsa-miR-301a-3p SMAD4 1.18000372861766 0.00831128124191879 -0.290880750164782 0.720889676191258 miRNAWalker2_validate;miRNATAP -0.118088619576369 0.000116341473786965 26019136 MicroRNA 301a 3p promotes pancreatic cancer progression via negative regulation of SMAD4; Furthermore SMAD4 was identified as a target gene of miR-301a-3p by cell as well as mice xenograft experiments; In PDAC tissue microarray a significantly inverse correlation between miR-301a-3p ISH scores and SMAD4 IHC scores were observed in both tumor and corresponding non-tumor tissues; MiR-301a-3p functions as a novel oncogene in PDAC and the oncogenic activity may involve its inhibition of the target gene SMAD4 progression pancreatic cancer hsa-miR-30b-5p SMAD4 -0.124247247359659 0.917685196303453 -0.290880750164782 0.720889676191258 mirMAP -0.114984596748122 0.0011779253354481 NA NA NA hsa-miR-30e-5p SMAD4 -0.318933868943279 0.850982406429589 -0.290880750164782 0.720889676191258 mirMAP -0.108824159732308 0.0257557314841602 NA NA NA hsa-miR-32-5p SMAD4 0.32053379451716 0.662616774636995 -0.290880750164782 0.720889676191258 mirMAP -0.182839505390668 5.90087142829289e-09 NA NA NA hsa-miR-320b SMAD4 0.941267876385794 0.0453505938355543 -0.290880750164782 0.720889676191258 miRNATAP -0.10330861405583 8.60793624505173e-05 NA NA NA hsa-miR-330-3p SMAD4 0.237023779714759 0.466174401969581 -0.290880750164782 0.720889676191258 mirMAP -0.11771738647317 0.000417415798096644 NA NA NA hsa-miR-34a-5p SMAD4 0.563661494017221 0.590317849063448 -0.290880750164782 0.720889676191258 miRNATAP -0.135747183616941 2.5237927208584e-05 22750848 Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network; Specifically in glioblastoma within the context of the global network promoter enrichment analysis of network edges uncovered a novel regulation of TGF-β signaling via a Smad4 transcriptomic network by miR-34a glioblastoma hsa-miR-361-5p SMAD4 0.517068298358111 0.640548482802509 -0.290880750164782 0.720889676191258 mirMAP -0.182566430585261 0.00549860480766203 NA NA NA hsa-miR-362-3p SMAD4 0.888146502223775 0.0147453056709009 -0.290880750164782 0.720889676191258 miRNATAP -0.113269373606989 4.43595320356158e-05 NA NA NA hsa-miR-369-3p SMAD4 0.658307572343713 0.108939404101946 -0.290880750164782 0.720889676191258 mirMAP -0.131196688101098 9.83846265644443e-05 NA NA NA hsa-miR-374a-5p SMAD4 0.280580933704653 0.711312203580958 -0.290880750164782 0.720889676191258 mirMAP -0.235424569425845 0.000403255576234335 NA NA NA hsa-miR-374b-5p SMAD4 0.00830204566239612 0.992518773949115 -0.290880750164782 0.720889676191258 mirMAP -0.168495947289316 0.000702283658138741 NA NA NA hsa-miR-409-3p SMAD4 1.06826077189128 0.086796304502529 -0.290880750164782 0.720889676191258 mirMAP -0.117954740135716 0.00105304417099389 NA NA NA hsa-miR-421 SMAD4 1.28183445098144 3.9841687793795e-06 -0.290880750164782 0.720889676191258 miRTarBase;miRanda;miRNATAP -0.135415845522913 2.14509306787876e-06 NA NA NA hsa-miR-450b-5p SMAD4 1.31989436603254 0.00773738577557236 -0.290880750164782 0.720889676191258 mirMAP -0.115896738428018 0.00015517880159877 NA NA NA hsa-miR-454-3p SMAD4 0.737467730442439 0.0944172375936656 -0.290880750164782 0.720889676191258 miRNAWalker2_validate;miRNATAP -0.142971060915538 3.66752682114237e-05 NA NA NA hsa-miR-493-5p SMAD4 1.34217716159816 0.00369808454520068 -0.290880750164782 0.720889676191258 mirMAP -0.131182789066324 1.6629001131115e-05 NA NA NA hsa-miR-576-5p SMAD4 0.744407899578399 0.146981973135162 -0.290880750164782 0.720889676191258 mirMAP -0.132545615190079 1.19500054451055e-05 NA NA NA hsa-miR-589-5p SMAD4 1.1821804664823 0.162299570206384 -0.290880750164782 0.720889676191258 miRNATAP -0.173827604622692 8.83219082977842e-06 NA NA NA hsa-miR-590-3p SMAD4 0.750834112502691 0.0721409718537464 -0.290880750164782 0.720889676191258 MirTarget;PITA;miRanda;miRNATAP -0.165912881096076 8.79477809927586e-09 NA NA NA hsa-miR-590-5p SMAD4 0.763126350124264 0.184296330120049 -0.290880750164782 0.720889676191258 miRanda -0.139556957805371 3.50474082856433e-07 NA NA NA hsa-miR-625-5p SMAD4 0.51369754623655 0.274843890626581 -0.290880750164782 0.720889676191258 MirTarget -0.129815030519407 2.91249560415629e-08 NA NA NA hsa-miR-141-3p SOX17 1.38768814668269 0.324793132237099 -0.825636091421319 0.0124073903839231 TargetScan -0.331729154883513 1.38412479779349e-27 22921431 Inhibition of SOX17 by microRNA 141 and methylation activates the WNT signaling pathway in esophageal cancer; MicroRNA 141 was also found to down-regulate SOX17 expression and activate the WNT signal pathway esophageal cancer hsa-miR-26b-5p SOX17 -0.640970973524183 0.623642285963207 -0.825636091421319 0.0124073903839231 miRNATAP -0.169674413600114 0.00689341721450201 NA NA NA hsa-miR-330-5p SOX17 0.522359698833297 0.46945472961169 -0.825636091421319 0.0124073903839231 miRanda -0.299020320536298 5.71298755433489e-07 NA NA NA hsa-miR-362-3p SOX17 0.888146502223775 0.0147453056709009 -0.825636091421319 0.0124073903839231 miRanda;miRNATAP -0.298867108735307 4.30695986084874e-09 NA NA NA hsa-miR-421 SOX17 1.28183445098144 3.9841687793795e-06 -0.825636091421319 0.0124073903839231 miRanda -0.308841165916842 4.69346101046922e-09 NA NA NA hsa-miR-542-3p SOX17 1.09096556479387 0.289651874996689 -0.825636091421319 0.0124073903839231 miRanda;miRNATAP -0.199565845378707 0.00889271105839985 NA NA NA hsa-miR-590-3p SOX17 0.750834112502691 0.0721409718537464 -0.825636091421319 0.0124073903839231 miRanda;miRNATAP -0.412223244416714 3.63882583064631e-15 NA NA NA hsa-miR-590-5p SOX17 0.763126350124264 0.184296330120049 -0.825636091421319 0.0124073903839231 miRanda -0.351176378542162 2.20211379076226e-12 NA NA NA hsa-miR-106b-5p TBL1X 0.947523403196215 0.405863421831729 -0.0693481274377232 0.921693045865819 mirMAP;miRNATAP -0.242424922396043 5.30500015581902e-05 NA NA NA hsa-miR-126-5p TBL1X 0.393018523145496 0.713269992183763 -0.0693481274377232 0.921693045865819 mirMAP -0.196663776276496 0.00234949329116085 NA NA NA hsa-miR-142-3p TBL1X 1.85020414100385 0.249422501446635 -0.0693481274377232 0.921693045865819 MirTarget;PITA;miRanda;miRNATAP -0.141327100281765 5.76328789494327e-06 NA NA NA hsa-miR-17-5p TBL1X 1.42323729519248 0.26500282246461 -0.0693481274377232 0.921693045865819 TargetScan;mirMAP;miRNATAP -0.147719400377912 0.00135794578884511 NA NA NA hsa-miR-181a-5p TBL1X 1.4443526859599 0.296372990368445 -0.0693481274377232 0.921693045865819 MirTarget;miRNATAP -0.247090388980202 0.000146873517886573 NA NA NA hsa-miR-181b-5p TBL1X 1.46153693463023 0.179461012757425 -0.0693481274377232 0.921693045865819 MirTarget;miRNATAP -0.177150390103532 0.00270280291445227 NA NA NA hsa-miR-185-5p TBL1X 1.18682153408723 0.147831753479942 -0.0693481274377232 0.921693045865819 MirTarget -0.400510080233707 1.34356963929528e-08 NA NA NA hsa-miR-192-5p TBL1X 1.83864778676109 0.37609734647626 -0.0693481274377232 0.921693045865819 miRNAWalker2_validate -0.210131363753877 8.16390693657987e-14 NA NA NA hsa-miR-19a-3p TBL1X 1.64946154674522 0.0268746411162676 -0.0693481274377232 0.921693045865819 mirMAP -0.156164109836392 0.000297933095927157 NA NA NA hsa-miR-19b-1-5p TBL1X 1.68690066069614 0.001519169322997 -0.0693481274377232 0.921693045865819 mirMAP -0.162692939130521 0.000587125542439462 NA NA NA hsa-miR-19b-3p TBL1X 0.806034733762941 0.431963517845538 -0.0693481274377232 0.921693045865819 mirMAP -0.15822740213169 0.0031384498410936 NA NA NA hsa-miR-20a-5p TBL1X 1.49559512103718 0.20819591223901 -0.0693481274377232 0.921693045865819 mirMAP;miRNATAP -0.135799233247838 0.00458953390326996 NA NA NA hsa-miR-2110 TBL1X 0.359978603621206 0.164447205047607 -0.0693481274377232 0.921693045865819 mirMAP -0.151193088167419 0.00353956816520667 NA NA NA hsa-miR-215-5p TBL1X 0.782657078958936 0.568836776061539 -0.0693481274377232 0.921693045865819 miRNAWalker2_validate -0.185361583491741 8.12867013992175e-17 NA NA NA hsa-miR-22-5p TBL1X 0.563707897845906 0.429790318970966 -0.0693481274377232 0.921693045865819 mirMAP -0.129998782502744 0.0209026726400752 NA NA NA hsa-miR-23a-3p TBL1X 0.727812777693753 0.65239699793942 -0.0693481274377232 0.921693045865819 mirMAP -0.27373579178366 0.006599545224786 NA NA NA hsa-miR-25-3p TBL1X 0.850158516705894 0.641399047473048 -0.0693481274377232 0.921693045865819 mirMAP -0.183829916029366 0.00867455830562401 NA NA NA hsa-miR-29b-1-5p TBL1X 1.09679805967173 0.0180205129273663 -0.0693481274377232 0.921693045865819 mirMAP -0.147303753037002 0.000107280887368409 NA NA NA hsa-miR-30d-3p TBL1X -0.0804985653060761 0.825203889451817 -0.0693481274377232 0.921693045865819 mirMAP -0.263561363026032 0.000211868210208649 NA NA NA hsa-miR-32-5p TBL1X 0.32053379451716 0.662616774636995 -0.0693481274377232 0.921693045865819 mirMAP -0.17591221012509 0.00146982848056276 NA NA NA hsa-miR-320b TBL1X 0.941267876385794 0.0453505938355543 -0.0693481274377232 0.921693045865819 mirMAP;miRNATAP -0.112563369168519 0.0137619027657847 NA NA NA hsa-miR-330-3p TBL1X 0.237023779714759 0.466174401969581 -0.0693481274377232 0.921693045865819 PITA;miRNATAP -0.215549887410397 0.000170394055259373 NA NA NA hsa-miR-340-5p TBL1X 0.390142516048182 0.456452075825761 -0.0693481274377232 0.921693045865819 MirTarget;mirMAP -0.236544414257366 0.00360372547716614 NA NA NA hsa-miR-3614-5p TBL1X 0.193652988396427 0.64084696968408 -0.0693481274377232 0.921693045865819 miRNATAP -0.127086426507804 0.0026069686121275 NA NA NA hsa-miR-362-3p TBL1X 0.888146502223775 0.0147453056709009 -0.0693481274377232 0.921693045865819 MirTarget;miRanda -0.174063400384162 0.00027996451844145 NA NA NA hsa-miR-450b-5p TBL1X 1.31989436603254 0.00773738577557236 -0.0693481274377232 0.921693045865819 mirMAP -0.195340912084021 0.000214553062174774 NA NA NA hsa-miR-484 TBL1X 0.340101271888636 0.69389289011036 -0.0693481274377232 0.921693045865819 PITA -0.188424054698431 0.000798866751863589 NA NA NA hsa-miR-584-5p TBL1X 1.5678638067071 0.101641871701789 -0.0693481274377232 0.921693045865819 mirMAP -0.116110190056511 0.00249958764707954 NA NA NA hsa-miR-589-3p TBL1X 0.91523747397743 0.0032660296472646 -0.0693481274377232 0.921693045865819 mirMAP -0.132064813097998 0.00494479101411471 NA NA NA hsa-miR-625-5p TBL1X 0.51369754623655 0.274843890626581 -0.0693481274377232 0.921693045865819 MirTarget -0.181265707155487 8.47012451719288e-06 NA NA NA hsa-miR-671-5p TBL1X 1.51754804287187 7.80556706545414e-05 -0.0693481274377232 0.921693045865819 MirTarget -0.202354509884363 1.13310021755725e-05 NA NA NA hsa-miR-769-5p TBL1X 0.930151246422741 0.11354401684175 -0.0693481274377232 0.921693045865819 PITA -0.144716131259684 0.0461559243617965 NA NA NA hsa-miR-92a-3p TBL1X 0.944279015811086 0.614191641461169 -0.0693481274377232 0.921693045865819 miRNAWalker2_validate;mirMAP -0.147981132107786 0.00985791365477199 NA NA NA hsa-miR-92b-3p TBL1X 1.05220938733495 0.263729863193421 -0.0693481274377232 0.921693045865819 mirMAP -0.127995443753252 0.0438774042443875 NA NA NA hsa-miR-93-3p TBL1X 1.0379867963088 0.0605530010506672 -0.0693481274377232 0.921693045865819 mirMAP -0.170713393684585 0.000198667056680606 NA NA NA hsa-miR-93-5p TBL1X 1.60480485311451 0.351308047161304 -0.0693481274377232 0.921693045865819 mirMAP;miRNATAP -0.210173483914476 2.94261125279441e-05 NA NA NA hsa-miR-96-5p TBL1X 1.14766037573765 0.0779994051337465 -0.0693481274377232 0.921693045865819 MirTarget;TargetScan -0.113413874574968 0.00238962216716254 NA NA NA hsa-miR-126-5p TBL1XR1 0.393018523145496 0.713269992183763 0.630002591428974 0.513589374439157 MirTarget;mirMAP -0.112574914475206 0.00123829706097359 NA NA NA hsa-miR-130a-3p TBL1XR1 0.410890280285832 0.607447245204235 0.630002591428974 0.513589374439157 MirTarget -0.138058378918579 7.86260969391015e-06 NA NA NA hsa-miR-145-3p TBL1XR1 -1.3341950140048 0.118376146114419 0.630002591428974 0.513589374439157 MirTarget -0.205202369995286 8.48032724011687e-16 NA NA NA hsa-miR-152-3p TBL1XR1 -0.0155559280739608 0.988199850270767 0.630002591428974 0.513589374439157 MirTarget -0.210556600748232 1.76652119791308e-05 NA NA NA hsa-miR-154-5p TBL1XR1 0.137785130821394 0.696984789390429 0.630002591428974 0.513589374439157 mirMAP -0.107044472284155 0.000170621590068827 NA NA NA hsa-miR-195-3p TBL1XR1 -0.522236286339218 0.0566853778570702 0.630002591428974 0.513589374439157 mirMAP -0.146188862737415 7.08361650984439e-06 NA NA NA hsa-miR-195-5p TBL1XR1 -0.954323940965843 0.175659217190861 0.630002591428974 0.513589374439157 MirTarget -0.269101657062569 1.1080440202387e-20 NA NA NA hsa-miR-28-3p TBL1XR1 -0.23038370966713 0.893658283701412 0.630002591428974 0.513589374439157 mirMAP -0.116571679125221 0.0271939142653248 NA NA NA hsa-miR-30a-3p TBL1XR1 -1.21767477941485 0.437259873660328 0.630002591428974 0.513589374439157 mirMAP -0.188359396767724 1.39350937499554e-12 NA NA NA hsa-miR-30e-3p TBL1XR1 -0.528630634076661 0.752496184625955 0.630002591428974 0.513589374439157 mirMAP -0.276371148004678 7.76184573127101e-09 NA NA NA hsa-miR-326 TBL1XR1 -0.686277598234758 0.130157755184283 0.630002591428974 0.513589374439157 MirTarget;PITA;miRanda -0.105333601410945 3.79130914592586e-06 NA NA NA hsa-miR-374a-3p TBL1XR1 0.00444091189256923 0.997279477304268 0.630002591428974 0.513589374439157 mirMAP -0.133095817006223 0.00444639862602206 NA NA NA hsa-miR-497-5p TBL1XR1 -0.365153126703569 0.562708968911863 0.630002591428974 0.513589374439157 MirTarget -0.253050503576401 6.07128817189555e-16 NA NA NA hsa-miR-106a-5p TCF7L1 0.634135628268838 0.223796223760607 -0.797845566389872 0.108079520681975 MirTarget -0.218948549137848 0.000392267339143343 NA NA NA hsa-miR-106b-5p TCF7L1 0.947523403196215 0.405863421831729 -0.797845566389872 0.108079520681975 MirTarget -0.600338367875202 1.76025082793215e-18 NA NA NA hsa-miR-130b-5p TCF7L1 1.29600920697695 0.0255462581963971 -0.797845566389872 0.108079520681975 MirTarget -0.406180605179504 1.42287830408604e-22 NA NA NA hsa-miR-132-3p TCF7L1 0.778103303628054 0.416119200227887 -0.797845566389872 0.108079520681975 MirTarget;miRNATAP -0.277251727412314 0.0102384163520575 NA NA NA hsa-miR-141-3p TCF7L1 1.38768814668269 0.324793132237099 -0.797845566389872 0.108079520681975 miRNAWalker2_validate -0.407401300379899 3.78029321837908e-35 NA NA NA hsa-miR-142-5p TCF7L1 1.06109968632125 0.257318725443238 -0.797845566389872 0.108079520681975 PITA -0.323013779465299 3.98594476596544e-12 NA NA NA hsa-miR-15b-3p TCF7L1 0.616287210571229 0.422509520506848 -0.797845566389872 0.108079520681975 miRNATAP -0.497557746237326 1.00855253347368e-21 NA NA NA hsa-miR-17-5p TCF7L1 1.42323729519248 0.26500282246461 -0.797845566389872 0.108079520681975 MirTarget;TargetScan -0.491100731734276 2.0859682578361e-21 NA NA NA hsa-miR-185-3p TCF7L1 1.29970093498066 0.00088003078050264 -0.797845566389872 0.108079520681975 MirTarget -0.402100013094029 3.19535818747665e-11 NA NA NA hsa-miR-200a-3p TCF7L1 1.70193303671238 0.209370802942576 -0.797845566389872 0.108079520681975 miRNAWalker2_validate -0.405182514690993 1.2373922056801e-35 NA NA NA hsa-miR-200b-3p TCF7L1 1.76966404687048 0.251078084855527 -0.797845566389872 0.108079520681975 miRNAWalker2_validate -0.442824188097337 3.15038718766065e-35 NA NA NA hsa-miR-200c-3p TCF7L1 1.38059869033872 0.459075461573504 -0.797845566389872 0.108079520681975 miRNAWalker2_validate -0.435333697818021 1.83949387439723e-30 NA NA NA hsa-miR-20a-5p TCF7L1 1.49559512103718 0.20819591223901 -0.797845566389872 0.108079520681975 MirTarget -0.475110390969324 1.99687625355394e-18 NA NA NA hsa-miR-212-3p TCF7L1 0.895869490569324 0.0316777138361649 -0.797845566389872 0.108079520681975 MirTarget;miRNATAP -0.286890625151444 0.000328448512177695 NA NA NA hsa-miR-30b-3p TCF7L1 0.0708830089216839 0.796242173864443 -0.797845566389872 0.108079520681975 MirTarget -0.314012100469958 3.41615945963763e-06 NA NA NA hsa-miR-30d-3p TCF7L1 -0.0804985653060761 0.825203889451817 -0.797845566389872 0.108079520681975 miRNATAP -0.442549684841588 1.78748447209774e-07 NA NA NA hsa-miR-330-5p TCF7L1 0.522359698833297 0.46945472961169 -0.797845566389872 0.108079520681975 miRanda -0.437140351559584 2.27897577852453e-11 NA NA NA hsa-miR-362-3p TCF7L1 0.888146502223775 0.0147453056709009 -0.797845566389872 0.108079520681975 miRanda;miRNATAP -0.412904467547091 1.11765496799138e-13 NA NA NA hsa-miR-429 TCF7L1 1.19781217693135 0.322310054579944 -0.797845566389872 0.108079520681975 miRNAWalker2_validate -0.346807267518487 4.6111991646637e-27 NA NA NA hsa-miR-455-3p TCF7L1 0.970088567389584 0.370523301857447 -0.797845566389872 0.108079520681975 MirTarget;PITA;miRNATAP -0.287563934843939 1.51938538483125e-14 NA NA NA hsa-miR-505-5p TCF7L1 0.423657953607018 0.332788995145813 -0.797845566389872 0.108079520681975 miRNATAP -0.195865754779064 0.000782594421968176 NA NA NA hsa-miR-542-3p TCF7L1 1.09096556479387 0.289651874996689 -0.797845566389872 0.108079520681975 MirTarget;miRanda;miRNATAP -0.206675369375244 0.0150572326379204 NA NA NA hsa-miR-590-3p TCF7L1 0.750834112502691 0.0721409718537464 -0.797845566389872 0.108079520681975 PITA;miRanda;miRNATAP -0.554101365266921 1.20276105153692e-22 NA NA NA hsa-miR-93-5p TCF7L1 1.60480485311451 0.351308047161304 -0.797845566389872 0.108079520681975 MirTarget -0.475820966632216 2.23349237297395e-16 NA NA NA hsa-miR-132-3p TCF7L2 0.778103303628054 0.416119200227887 0.0816165898257974 0.921805003901646 miRNATAP -0.103470513263083 0.0437766038511768 NA NA NA hsa-miR-212-3p TCF7L2 0.895869490569324 0.0316777138361649 0.0816165898257974 0.921805003901646 miRNATAP -0.151320618907421 6.13396394027427e-05 NA NA NA hsa-miR-26a-5p TCF7L2 -0.459645668105514 0.761702789258103 0.0816165898257974 0.921805003901646 miRNATAP -0.125734844479811 0.0209144814954049 NA NA NA hsa-miR-125a-5p TP53 -0.134418454752295 0.908401725750299 0.331361195654994 0.713213515012239 miRNAWalker2_validate;miRTarBase;miRanda -0.244153419981785 0.000286434605400778 26389681;21777146;23079745 Mechanistically inactivation of miR-125a during cervical carcinogenesis was caused by HPV suppression of p53 expression;In addition wild-type p53 mRNA and protein expression was increased by hsa-miR-125a-5p overexpression; Moreover blocking wild-type p53 attenuated the effect of hsa-miR-125a-5p on apoptosis; In loss-of-function experiments wild-type p53 mRNA and protein expression was decreased by blocking hsa-miR-125a-5p; The effect of hsa-miR-125a-5p inhibitor on apoptosis was also weakened by blocking wild-type p53;Furthermore treatment of HCC cells with 5-aza-2'-deoxycytidine or ectopic expression of wildtype but not mutated p53 restored miR-125a-5p and miR-125b expression and inhibited tumor cell growth suggesting their regulation by promoter methylation and p53 activity tumorigenesis;; cervical and endocervical cancer;lung cancer;liver cancer hsa-miR-125b-5p TP53 0.127721571299908 0.9163354562791 0.331361195654994 0.713213515012239 miRNAWalker2_validate;miRTarBase -0.117991649104916 0.0168993998720041 24846940;26335100;24137477;26686386;24402874;21399871;23585871;24762088;24169356;23079745 The results revealed that hsa-miR-125b may regulate multiple biological processes and signal transduction pathways and drug-resistant occurrence is associated with cell proliferation cell apoptosis cell cycle and signaling pathways including MAPK Wnt and p53;The carboxy terminal domain of connexin 43 CT Cx43 modulates the expression of p53 by altering miR 125b expression in low grade human breast cancers; In addition CT-Cx43 was exogenously expressed in the breast cancer-derived cell line MCF-7 and its effect on the expression of miR-125b and its downstream target p53 were evaluated as well as its effect on cellular proliferation and death using MTT and LDH assays respectively; Interestingly we found that miR-125b a negative regulator of p53 exhibited an inverse expression relationship with CT-Cx43 in the breast cancer samples tested;TP53 and hsa-miR-125b were observed to form a self-adaptation association;In this study we have investigated the delivery and transfection of wild-type wt- p53 and microRNA-125b miR-125b expressing plasmid DNA in SK-LU-1 human lung adenocarcinoma cells as well as in KrasG12D/p53fl/fl KP genetically engineered mouse model of lung cancer;miR-34a is directly regulated by p53 and acts as tumor suppressor while miR-125b plays a significant role in immune response and apoptosis;In vitro assays revealed that overexpression of miR-125b repressed the endogenous level of p53 protein in human colorectal cancer cells;In this study we further extend our studies by showing that miR-125b represses the protein product of the ink4a/ARF locus p14ARF in two prostate cancer cell lines LNCaP wild type-p53 and 22Rv1 both wild type and mutant p53 as well as in the PC-346C prostate cancer xenograft model that lentivirally overexpressed miR-125b;A stable overexpression of miR-125b in human melanoma cell line Mel-Juso resulted in a G0/G1 cell cycle block and emergence of large cells expressing senescence markers: senescence-associated beta-galactosidase p21 p27 and p53;MiR 125b acts as an oncogene in glioblastoma cells and inhibits cell apoptosis through p53 and p38MAPK independent pathways; Further studies reveal that p53 is regulated by miR-125b; However downregulation of the endogenous miR-125b also results in p53-independent apoptotic pathway leading to apoptosis in p53 mutated U251 cells and p53 knockdown U87 cells;Furthermore treatment of HCC cells with 5-aza-2'-deoxycytidine or ectopic expression of wildtype but not mutated p53 restored miR-125a-5p and miR-125b expression and inhibited tumor cell growth suggesting their regulation by promoter methylation and p53 activity; To show the clinical significance of these findings mutations in the DNA binding domain of p53 and promoter methylation of miR-125b were investigated; Four out of nine patients with induced SIRT7 carried mutations in the p53 gene and one patient showed hypermethylation of the miR-125b promoter region ;;;;immune resistance;;;;; gastric cancer;breast cancer;pancreatic cancer;lung cancer;cervical and endocervical cancer;colorectal cancer;prostate cancer;melanoma;glioblastoma;liver cancer hsa-miR-130a-3p VANGL1 0.410890280285832 0.607447245204235 0.482259817717352 0.518735791563149 mirMAP -0.100329029551474 0.00354821817018101 NA NA NA hsa-miR-139-5p VANGL1 -1.31022051532559 0.0657735573826271 0.482259817717352 0.518735791563149 miRanda -0.16073139472034 2.77974250747435e-06 NA NA NA hsa-miR-195-5p VANGL1 -0.954323940965843 0.175659217190861 0.482259817717352 0.518735791563149 mirMAP -0.224042564295357 1.13431821759058e-11 NA NA NA hsa-miR-218-5p VANGL1 -0.401334252515531 0.54877923107825 0.482259817717352 0.518735791563149 mirMAP -0.166659088971149 6.51729173877518e-08 NA NA NA hsa-miR-26a-5p VANGL1 -0.459645668105514 0.761702789258103 0.482259817717352 0.518735791563149 mirMAP -0.303615299926592 3.95416986952146e-08 NA NA NA hsa-let-7d-5p VANGL2 0.556268325000502 0.620991013688543 -0.610594071922248 0.280177372892479 miRNATAP -0.677992108470028 2.25033484204186e-06 NA NA NA hsa-let-7g-3p VANGL2 0.692324017258497 0.345964739358737 -0.610594071922248 0.280177372892479 miRNATAP -0.212762145507923 0.00127463031203376 NA NA NA hsa-let-7g-5p VANGL2 0.242876485228015 0.854288116985674 -0.610594071922248 0.280177372892479 miRNATAP -0.571082812918991 0.00017978817038065 NA NA NA hsa-let-7i-5p VANGL2 0.96474066301535 0.435264821031699 -0.610594071922248 0.280177372892479 miRNATAP -0.671911473484913 0.000224142220176136 NA NA NA hsa-miR-106b-5p VANGL2 0.947523403196215 0.405863421831729 -0.610594071922248 0.280177372892479 mirMAP -0.214831540200775 0.048113515410425 NA NA NA hsa-miR-107 VANGL2 0.808649908398562 0.357609254490153 -0.610594071922248 0.280177372892479 miRanda -0.558944912768514 0.000468258643652736 NA NA NA hsa-miR-146b-3p VANGL2 2.20932741242973 0.0129642965316297 -0.610594071922248 0.280177372892479 PITA -0.373637058834013 1.66694812810155e-05 NA NA NA hsa-miR-15b-3p VANGL2 0.616287210571229 0.422509520506848 -0.610594071922248 0.280177372892479 mirMAP -0.370712614270236 6.73359870021811e-06 NA NA NA hsa-miR-17-5p VANGL2 1.42323729519248 0.26500282246461 -0.610594071922248 0.280177372892479 mirMAP -0.292668400280577 0.000383115666105036 NA NA NA hsa-miR-185-5p VANGL2 1.18682153408723 0.147831753479942 -0.610594071922248 0.280177372892479 MirTarget -0.591968213109022 3.47169398937022e-06 NA NA NA hsa-miR-186-5p VANGL2 0.273626466122302 0.807169118774403 -0.610594071922248 0.280177372892479 mirMAP -0.497340114778666 0.000246086513496263 NA NA NA hsa-miR-20a-5p VANGL2 1.49559512103718 0.20819591223901 -0.610594071922248 0.280177372892479 mirMAP -0.293343036672007 0.00060211842527434 NA NA NA hsa-miR-26b-5p VANGL2 -0.640970973524183 0.623642285963207 -0.610594071922248 0.280177372892479 miRNAWalker2_validate;MirTarget -0.252082852413255 0.0152758718135587 NA NA NA hsa-miR-27a-3p VANGL2 0.505339123854064 0.734502884016765 -0.610594071922248 0.280177372892479 miRNATAP -0.535743246414916 0.000412274991548492 NA NA NA hsa-miR-30d-5p VANGL2 0.218119609086939 0.898751473051369 -0.610594071922248 0.280177372892479 mirMAP -0.414750794072143 0.0204840381095058 NA NA NA hsa-miR-30e-5p VANGL2 -0.318933868943279 0.850982406429589 -0.610594071922248 0.280177372892479 mirMAP -0.422698531895419 0.00484893425188349 NA NA NA hsa-miR-33a-3p VANGL2 -0.0493858782224366 0.86469054162599 -0.610594071922248 0.280177372892479 miRNATAP -0.250239696098028 0.00531914891976936 NA NA NA hsa-miR-3614-5p VANGL2 0.193652988396427 0.64084696968408 -0.610594071922248 0.280177372892479 miRNATAP -0.425824324419184 8.34443683242809e-09 NA NA NA hsa-miR-362-3p VANGL2 0.888146502223775 0.0147453056709009 -0.610594071922248 0.280177372892479 PITA;miRanda;miRNATAP -0.308753781007153 0.000321624332163544 NA NA NA hsa-miR-362-5p VANGL2 1.36961823784152 0.0184116687226066 -0.610594071922248 0.280177372892479 mirMAP -0.256001204409266 0.0011532884897377 NA NA NA hsa-miR-378a-5p VANGL2 -0.801036358195498 0.420699554699246 -0.610594071922248 0.280177372892479 MirTarget -0.587412948604684 9.03957154322032e-09 NA NA NA hsa-miR-429 VANGL2 1.19781217693135 0.322310054579944 -0.610594071922248 0.280177372892479 miRNATAP -0.207591893508097 7.3492030151056e-05 NA NA NA hsa-miR-501-5p VANGL2 1.51510872844603 0.000249681492153084 -0.610594071922248 0.280177372892479 mirMAP -0.231596769348487 0.00319414621056845 NA NA NA hsa-miR-511-5p VANGL2 0.743122530026616 0.141222906192463 -0.610594071922248 0.280177372892479 MirTarget -0.303806816886595 0.000148219288252746 NA NA NA hsa-miR-582-3p VANGL2 -0.288909714315645 0.798328823284484 -0.610594071922248 0.280177372892479 mirMAP -0.334294835420352 0.000269976326634535 NA NA NA hsa-miR-582-5p VANGL2 -0.0750818699965312 0.895875799292592 -0.610594071922248 0.280177372892479 PITA;miRNATAP -0.436446362926787 9.56146588033661e-06 NA NA NA hsa-miR-589-3p VANGL2 0.91523747397743 0.0032660296472646 -0.610594071922248 0.280177372892479 mirMAP -0.487272105184391 2.83561719925387e-09 NA NA NA hsa-miR-589-5p VANGL2 1.1821804664823 0.162299570206384 -0.610594071922248 0.280177372892479 mirMAP -0.524620849741312 1.38515013644729e-05 NA NA NA hsa-miR-590-3p VANGL2 0.750834112502691 0.0721409718537464 -0.610594071922248 0.280177372892479 miRanda -0.37902642814565 2.66090652044265e-05 NA NA NA hsa-miR-7-1-3p VANGL2 0.642828512342857 0.399017154673609 -0.610594071922248 0.280177372892479 mirMAP -0.410926352158587 9.77554161444575e-07 NA NA NA hsa-miR-92a-3p VANGL2 0.944279015811086 0.614191641461169 -0.610594071922248 0.280177372892479 miRNAWalker2_validate -0.23835751723568 0.0204454633212873 NA NA NA hsa-miR-96-5p VANGL2 1.14766037573765 0.0779994051337465 -0.610594071922248 0.280177372892479 TargetScan -0.298625164332837 6.42804991726928e-06 NA NA NA hsa-miR-107 WIF1 0.808649908398562 0.357609254490153 -4.42950593575037 1.66617326759588e-06 miRanda -0.638000235259256 0.0429632595930754 NA NA NA hsa-miR-140-3p WIF1 0.0424028925269262 0.97506468860784 -4.42950593575037 1.66617326759588e-06 PITA;miRNATAP -0.747467480524538 0.0380055471494107 NA NA NA hsa-miR-362-3p WIF1 0.888146502223775 0.0147453056709009 -4.42950593575037 1.66617326759588e-06 miRanda -0.408636214071626 0.0157058520065466 NA NA NA hsa-miR-485-3p WIF1 0.967037740891141 0.00391462029256323 -4.42950593575037 1.66617326759588e-06 PITA;miRNATAP -0.394847264508328 0.0292989254954485 NA NA NA hsa-miR-378a-3p WNT10A -0.753476146177009 0.54766442023947 0.254090837212513 0.618821948237221 MirTarget;miRNATAP -0.300020446519153 0.0217501762983613 NA NA NA hsa-miR-148b-3p WNT10B 0.686272171036606 0.498004854065858 -0.462693476708216 0.213604933740522 MirTarget -0.234610403711885 0.0161601157880197 NA NA NA hsa-miR-188-5p WNT10B 1.39119308895556 0.000791755580412654 -0.462693476708216 0.213604933740522 PITA -0.138782008699238 0.0245032162356935 NA NA NA hsa-miR-320b WNT10B 0.941267876385794 0.0453505938355543 -0.462693476708216 0.213604933740522 miRanda -0.277091003023879 3.61751652968573e-05 NA NA NA hsa-miR-107 WNT16 0.808649908398562 0.357609254490153 -0.391445378727738 0.478363357566749 miRanda;miRNATAP -0.539599383482006 0.00198471567134267 NA NA NA hsa-miR-146b-3p WNT16 2.20932741242973 0.0129642965316297 -0.391445378727738 0.478363357566749 MirTarget -0.228698119663276 0.0168448032364744 NA NA NA hsa-miR-200b-3p WNT16 1.76966404687048 0.251078084855527 -0.391445378727738 0.478363357566749 MirTarget -0.180030136434788 0.00634285654731372 NA NA NA hsa-miR-200c-3p WNT16 1.38059869033872 0.459075461573504 -0.391445378727738 0.478363357566749 MirTarget -0.280160044580026 3.87197861018716e-05 NA NA NA hsa-miR-27a-3p WNT16 0.505339123854064 0.734502884016765 -0.391445378727738 0.478363357566749 MirTarget -0.75689165117027 3.84765991930109e-06 NA NA NA hsa-miR-339-5p WNT16 0.515631910744412 0.482415357074891 -0.391445378727738 0.478363357566749 miRanda -0.241871475763128 0.00370088380300677 NA NA NA hsa-miR-429 WNT16 1.19781217693135 0.322310054579944 -0.391445378727738 0.478363357566749 MirTarget;miRanda -0.193057056482932 0.000749144996622535 NA NA NA hsa-miR-450b-5p WNT16 1.31989436603254 0.00773738577557236 -0.391445378727738 0.478363357566749 PITA -0.247642478007604 0.0169934471208827 NA NA NA hsa-miR-577 WNT16 0.356857462342957 0.638858200569284 -0.391445378727738 0.478363357566749 mirMAP -0.108483076033771 0.0290322811408118 NA NA NA hsa-miR-590-3p WNT16 0.750834112502691 0.0721409718537464 -0.391445378727738 0.478363357566749 PITA;miRanda;mirMAP -0.384617868289403 9.44727482130651e-05 NA NA NA hsa-miR-629-3p WNT16 0.551260052178687 0.20899418574898 -0.391445378727738 0.478363357566749 MirTarget -0.358853335096441 3.36742301209538e-06 NA NA NA hsa-miR-139-5p WNT2 -1.31022051532559 0.0657735573826271 5.02098441324288 1.56234819016467e-21 miRanda -1.148978659305 2.14191205241678e-16 NA NA NA hsa-miR-130b-3p WNT2B 1.118725142912 0.0736094039162448 -0.167395317638549 0.650193236437666 MirTarget -0.381816949773996 1.01639134185414e-10 NA NA NA hsa-miR-186-5p WNT2B 0.273626466122302 0.807169118774403 -0.167395317638549 0.650193236437666 mirMAP -0.60156915913634 3.98291559001278e-08 NA NA NA hsa-miR-301a-3p WNT2B 1.18000372861766 0.00831128124191879 -0.167395317638549 0.650193236437666 MirTarget -0.374748612361103 1.08396317373738e-06 NA NA NA hsa-miR-429 WNT2B 1.19781217693135 0.322310054579944 -0.167395317638549 0.650193236437666 miRNATAP -0.1977407432296 3.68204544581491e-06 NA NA NA hsa-miR-454-3p WNT2B 0.737467730442439 0.0944172375936656 -0.167395317638549 0.650193236437666 MirTarget -0.449176016616086 2.29394273438948e-07 NA NA NA hsa-miR-576-5p WNT2B 0.744407899578399 0.146981973135162 -0.167395317638549 0.650193236437666 mirMAP -0.511279493316018 7.25011598246553e-12 NA NA NA hsa-miR-199a-5p WNT4 0.910307846610808 0.47634283513759 -1.33782771039496 0.00335153213626616 miRanda -0.26338502354093 0.0326431033392842 NA NA NA hsa-miR-155-5p WNT5A 0.689059012865632 0.586621132607867 0.812972095313325 0.22802965995901 miRNAWalker2_validate;mirMAP -0.114796461161049 0.024682569382517 NA NA NA hsa-miR-195-3p WNT5A -0.522236286339218 0.0566853778570702 0.812972095313325 0.22802965995901 MirTarget;mirMAP;miRNATAP -0.148725219773471 0.0377472053063961 NA NA NA hsa-miR-26a-5p WNT5A -0.459645668105514 0.761702789258103 0.812972095313325 0.22802965995901 mirMAP;miRNATAP -0.340648066160227 0.00211404332043131 24972966 MiR 26a inhibits prostate cancer progression by repression of Wnt5a; It was predicted that Wnt5a was a potential target gene of miR-26a by bioinformatics analysis; Then luciferase assay and Western blot analysis identified that Wnt5a was a new direct target gene of miR-26a and miR-26a inhibited prostate cancer progression via Wnt5a; Altogether the findings suggested that miR-26a may function as a tumor suppressor in prostate cancer by targeting Wnt5a progression prostate cancer hsa-miR-30a-3p WNT5A -1.21767477941485 0.437259873660328 0.812972095313325 0.22802965995901 mirMAP -0.151022314825935 0.0118533816657614 NA NA NA hsa-miR-30a-5p WNT5A -0.622409301903435 0.733062880166898 0.812972095313325 0.22802965995901 miRNAWalker2_validate;mirMAP -0.155111583443187 0.036554385092701 NA NA NA hsa-miR-30b-5p WNT5A -0.124247247359659 0.917685196303453 0.812972095313325 0.22802965995901 mirMAP -0.152644743736262 0.0334014583602561 NA NA NA hsa-miR-30c-5p WNT5A -0.208331154216021 0.863518338736092 0.812972095313325 0.22802965995901 mirMAP -0.194983784925679 0.0232253008060756 NA NA NA hsa-miR-30e-3p WNT5A -0.528630634076661 0.752496184625955 0.812972095313325 0.22802965995901 mirMAP -0.293864576182268 0.00567521362864098 NA NA NA hsa-miR-30e-5p WNT5A -0.318933868943279 0.850982406429589 0.812972095313325 0.22802965995901 mirMAP -0.354031602781626 0.000281513933154636 NA NA NA hsa-miR-374b-5p WNT5A 0.00830204566239612 0.992518773949115 0.812972095313325 0.22802965995901 MirTarget;miRNATAP -0.297328533456634 0.00304842517082449 NA NA NA hsa-miR-185-5p WNT5B 1.18682153408723 0.147831753479942 -1.08792157270754 0.00886860053602839 miRNAWalker2_validate -0.401975516379617 4.85313741038971e-05 NA NA NA hsa-miR-542-3p WNT5B 1.09096556479387 0.289651874996689 -1.08792157270754 0.00886860053602839 miRanda -0.214062264548315 0.0281461458228487 NA NA NA hsa-miR-9-5p WNT7B -0.699935578986425 0.563236185947538 4.27740323502453 1.86648757892566e-12 mirMAP -0.255720390731308 0.0219698511889992 NA NA NA hsa-let-7a-3p WNT9A 0.180588894055192 0.807497649839616 -0.999887425756723 0.0153794303897619 mirMAP -0.801096438138529 1.21286621676983e-10 NA NA NA hsa-let-7a-5p WNT9A 0.337419025870977 0.868932974829364 -0.999887425756723 0.0153794303897619 TargetScan -0.57491456100216 0.00631084381677452 NA NA NA hsa-let-7b-3p WNT9A 0.273132474559554 0.682533246372485 -0.999887425756723 0.0153794303897619 mirMAP -0.928467484950923 5.01328009708764e-08 NA NA NA hsa-let-7f-1-3p WNT9A 1.02975898416111 0.00216616040865014 -0.999887425756723 0.0153794303897619 mirMAP -1.16622736751676 1.60408094016451e-21 NA NA NA hsa-miR-148a-3p WNT9A -0.336734438265406 0.874732520340819 -0.999887425756723 0.0153794303897619 mirMAP -0.743671620378306 6.20117635046045e-19 NA NA NA hsa-miR-148b-3p WNT9A 0.686272171036606 0.498004854065858 -0.999887425756723 0.0153794303897619 mirMAP -1.12675776952834 6.668674207871e-19 NA NA NA hsa-miR-15a-5p WNT9A 0.999503864534946 0.325292066441584 -0.999887425756723 0.0153794303897619 mirMAP -1.36653026360388 2.96183401949352e-30 NA NA NA hsa-miR-15b-5p WNT9A 0.441873888832829 0.683456288766732 -0.999887425756723 0.0153794303897619 mirMAP -1.21116399137213 2.11817909650553e-25 NA NA NA hsa-miR-16-5p WNT9A 0.294875982844909 0.811640142720194 -0.999887425756723 0.0153794303897619 mirMAP -1.03043095990865 2.16591074259425e-23 NA NA NA hsa-miR-181a-2-3p WNT9A 0.729676472827631 0.555027073050818 -0.999887425756723 0.0153794303897619 mirMAP -0.346994544404903 0.0156777287645624 NA NA NA hsa-miR-185-3p WNT9A 1.29970093498066 0.00088003078050264 -0.999887425756723 0.0153794303897619 mirMAP -0.714396212331558 4.64960944622266e-12 NA NA NA hsa-miR-193a-3p WNT9A 0.125692968009939 0.782518392846951 -0.999887425756723 0.0153794303897619 mirMAP -0.328848900398673 0.0209796403038217 NA NA NA hsa-miR-22-3p WNT9A 0.559849034376487 0.80225442109778 -0.999887425756723 0.0153794303897619 mirMAP -0.622544396231122 0.0050825268953125 NA NA NA hsa-miR-32-5p WNT9A 0.32053379451716 0.662616774636995 -0.999887425756723 0.0153794303897619 mirMAP -1.01028671907348 1.58148525015754e-21 NA NA NA hsa-miR-330-3p WNT9A 0.237023779714759 0.466174401969581 -0.999887425756723 0.0153794303897619 mirMAP -0.640738331000324 3.93099912926554e-08 NA NA NA hsa-miR-331-3p WNT9A 0.842954893306256 0.176786083671554 -0.999887425756723 0.0153794303897619 mirMAP -0.59509948998551 2.58862690901914e-09 NA NA NA hsa-miR-335-5p WNT9A 0.484676450705085 0.267046535449854 -0.999887425756723 0.0153794303897619 miRNAWalker2_validate -0.579544993491968 7.13600679042578e-10 NA NA NA hsa-miR-424-5p WNT9A 0.778229637040266 0.39502076082444 -0.999887425756723 0.0153794303897619 mirMAP -0.61856883395622 1.7537631598928e-13 NA NA NA hsa-miR-532-3p WNT9A 1.13744435296751 0.160148333150432 -0.999887425756723 0.0153794303897619 mirMAP -0.761624723355454 3.95841649833641e-25 NA NA NA hsa-miR-589-3p WNT9A 0.91523747397743 0.0032660296472646 -0.999887425756723 0.0153794303897619 mirMAP -0.819615725611833 1.48983085677189e-19 NA NA NA hsa-miR-96-5p WNT9A 1.14766037573765 0.0779994051337465 -0.999887425756723 0.0153794303897619 mirMAP -0.791026687163156 1.97676915600647e-30 NA NA NA