miRNA	gene	miRNA_log2FC	miRNA_pvalue	gene_log2FC	gene_pvalue	interactions	correlation_beta	correlation_pvalue	PMID	evidence	outcome	cancer
hsa-miR-200c-3p	ABAT	6.47012025883743	2.64500707716408e-26	0.0592316470201539	0.94069487535703	MirTarget	-0.176087024283366	0.00957306151711354		NA	NA	NA
hsa-miR-200c-3p	ACTC1	6.47012025883743	2.64500707716408e-26	-6.25834225127145	4.25760506671468e-06	MirTarget	-0.546107320999917	2.94356637771889e-06		NA	NA	NA
hsa-miR-200c-3p	ADAMTS3	6.47012025883743	2.64500707716408e-26	-3.48130921698636	0.00157655828861854	miRNATAP	-0.377623015524411	6.02959622939037e-05		NA	NA	NA
hsa-miR-200c-3p	ADCY2	6.47012025883743	2.64500707716408e-26	-5.73916016086503	0.000188747903845494	MirTarget;miRNATAP	-0.371982978074438	0.00505555237095131		NA	NA	NA
hsa-miR-200c-3p	AFF3	6.47012025883743	2.64500707716408e-26	-4.68601926745895	6.97738857315821e-07	MirTarget;miRNATAP	-0.55212265723495	3.9391188482878e-12		NA	NA	NA
hsa-miR-200c-3p	AMOTL2	6.47012025883743	2.64500707716408e-26	-0.940829609541429	0.108108702719991	MirTarget;miRNATAP	-0.1343557040744	0.00723410166044823		NA	NA	NA
hsa-miR-200c-3p	AP1S2	6.47012025883743	2.64500707716408e-26	-2.97358822625767	7.9362568706807e-10	MirTarget;miRNATAP	-0.329480064216835	4.3008369341744e-16		NA	NA	NA
hsa-miR-200c-3p	ARHGAP20	6.47012025883743	2.64500707716408e-26	-3.55822292741935	0.00051193912705013	MirTarget;miRNATAP	-0.516261457247328	2.17434195128011e-09		NA	NA	NA
hsa-miR-200c-3p	ARHGAP28	6.47012025883743	2.64500707716408e-26	-2.52434334336667	0.0426301253491	MirTarget	-0.356547032207822	0.000798253720239243		NA	NA	NA
hsa-miR-200c-3p	ARHGAP6	6.47012025883743	2.64500707716408e-26	-5.44836894935852	1.96802214068867e-09	MirTarget	-0.509431171385338	4.910827342572e-11		NA	NA	NA
hsa-miR-200c-3p	ARHGEF17	6.47012025883743	2.64500707716408e-26	-2.19274449241421	7.74983254330356e-06	miRNATAP	-0.177995834255429	2.33933461504506e-05		NA	NA	NA
hsa-miR-200c-3p	ARL10	6.47012025883743	2.64500707716408e-26	-0.752217820421508	0.352817357063532	mirMAP	-0.229772979163614	0.000855442710339485		NA	NA	NA
hsa-miR-200c-3p	ARL15	6.47012025883743	2.64500707716408e-26	-0.849758331016717	0.149470768011084	MirTarget	-0.149955520240535	0.00285758919987027		NA	NA	NA
hsa-miR-200c-3p	ARL2BP	6.47012025883743	2.64500707716408e-26	-0.966372887595977	0.00153581275849949	miRNATAP	-0.124247276368815	1.38801634754115e-06		NA	NA	NA
hsa-miR-200c-3p	ASAP1	6.47012025883743	2.64500707716408e-26	-0.151385521914876	0.714275215082014	MirTarget;miRNATAP	-0.106052957666657	0.002535587931351		NA	NA	NA
hsa-miR-200c-3p	ATP11C	6.47012025883743	2.64500707716408e-26	-0.873029093406436	0.0904671829482675	MirTarget	-0.107430150824264	0.0148151301443591		NA	NA	NA
hsa-miR-200c-3p	ATXN1	6.47012025883743	2.64500707716408e-26	-1.43276235653597	0.00387135474046219	MirTarget;miRNATAP	-0.179479344164765	2.07717421988575e-05		NA	NA	NA
hsa-miR-200c-3p	BACH2	6.47012025883743	2.64500707716408e-26	-2.72766253823841	0.00174098676396876	mirMAP	-0.283790970969102	0.000139272883667789		NA	NA	NA
hsa-miR-200c-3p	BASP1	6.47012025883743	2.64500707716408e-26	-1.12470485256406	0.329085541806455	miRNATAP	-0.291463690661245	0.00303872235672823		NA	NA	NA
hsa-miR-200c-3p	BCL2	6.47012025883743	2.64500707716408e-26	-3.06316187948847	1.08810932834372e-05	miRNAWalker2_validate;miRTarBase;mirMAP	-0.20320611228092	0.000726337324039896		NA	NA	NA
hsa-miR-200c-3p	BNC2	6.47012025883743	2.64500707716408e-26	-6.04221863045668	1.28592064404143e-10	MirTarget	-0.65280193687476	1.38699243353219e-16		NA	NA	NA
hsa-miR-200c-3p	C11orf87	6.47012025883743	2.64500707716408e-26	-3.96353102190994	0.00130676712385478	miRNATAP	-0.406441450283731	0.000117064165995019		NA	NA	NA
hsa-miR-200c-3p	C17orf51	6.47012025883743	2.64500707716408e-26	-1.61262787783029	0.0604777801181298	mirMAP	-0.246973088270863	0.000750162918813903		NA	NA	NA
hsa-miR-200c-3p	CACNA1C	6.47012025883743	2.64500707716408e-26	-5.47617607166292	9.14588480929742e-11	MirTarget	-0.479623033848176	3.52519696145397e-11		NA	NA	NA
hsa-miR-200c-3p	CALU	6.47012025883743	2.64500707716408e-26	-0.8475888565283	0.0346041694359576	MirTarget	-0.108838924612178	0.00144274968876235		NA	NA	NA
hsa-miR-200c-3p	CBL	6.47012025883743	2.64500707716408e-26	-0.223305458230699	0.601450588204973	MirTarget;mirMAP	-0.102551823392254	0.00480588017413537		NA	NA	NA
hsa-miR-200c-3p	CDK17	6.47012025883743	2.64500707716408e-26	-1.12328504410322	0.000900632997943985	MirTarget;miRNATAP	-0.106273110517668	0.000228667988246372		NA	NA	NA
hsa-miR-200c-3p	CDK6	6.47012025883743	2.64500707716408e-26	0.50406574702617	0.551236779554206	mirMAP	-0.183617248048526	0.0110434380289459		NA	NA	NA
hsa-miR-200c-3p	CELF2	6.47012025883743	2.64500707716408e-26	-2.48163199573256	0.00126436670635573	mirMAP;miRNATAP	-0.269914129826243	4.00377211196354e-05		NA	NA	NA
hsa-miR-200c-3p	CEP68	6.47012025883743	2.64500707716408e-26	-1.77239510025922	6.85934034025852e-06	MirTarget	-0.125803290215139	0.000205071181607758		NA	NA	NA
hsa-miR-200c-3p	CFL2	6.47012025883743	2.64500707716408e-26	-3.32978432910491	1.5605491931502e-10	MirTarget;miRNATAP	-0.214648789643005	2.10821306697854e-06	23497265	We characterized one of the target genes of miR-200c CFL2 and demonstrated that CFL2 is overexpressed in aggressive breast cancer cell lines and can be significantly down-regulated by exogenous miR-200c		breast cancer
hsa-miR-200c-3p	CHD9	6.47012025883743	2.64500707716408e-26	-0.30348060334992	0.47580418564213	mirMAP;miRNATAP	-0.10736843868053	0.00300541602750714		NA	NA	NA
hsa-miR-200c-3p	CHN2	6.47012025883743	2.64500707716408e-26	-2.37888534467444	0.00852575357468979	MirTarget	-0.184724590702903	0.0174623578097875		NA	NA	NA
hsa-miR-200c-3p	CHRDL1	6.47012025883743	2.64500707716408e-26	-10.0047369671436	6.00614874866061e-09	MirTarget	-0.925481894290808	3.10515468942422e-10		NA	NA	NA
hsa-miR-200c-3p	CHST11	6.47012025883743	2.64500707716408e-26	0.00939719081667834	0.990919854205087	mirMAP	-0.201524725646343	0.00420672100550414		NA	NA	NA
hsa-miR-200c-3p	CHST2	6.47012025883743	2.64500707716408e-26	-0.561153608977267	0.584518016033006	miRNATAP	-0.202833959724376	0.0208239294825107		NA	NA	NA
hsa-miR-200c-3p	CITED2	6.47012025883743	2.64500707716408e-26	-2.81556973832692	4.67183448218434e-07	miRNATAP	-0.147426120705614	0.00238275307632587		NA	NA	NA
hsa-miR-200c-3p	CLIC4	6.47012025883743	2.64500707716408e-26	-2.06990721699453	5.50896805060539e-06	MirTarget;miRNATAP	-0.195597387706071	4.82051350167941e-07		NA	NA	NA
hsa-miR-200c-3p	CLIP2	6.47012025883743	2.64500707716408e-26	-1.7901905733407	0.00422954927682562	MirTarget;miRNATAP	-0.182968711488553	0.000630181793591354		NA	NA	NA
hsa-miR-200c-3p	CNN3	6.47012025883743	2.64500707716408e-26	-1.93238478845593	5.87025127112623e-05	MirTarget;miRNATAP	-0.164602763860358	6.48264308341628e-05		NA	NA	NA
hsa-miR-200c-3p	CNTFR	6.47012025883743	2.64500707716408e-26	-4.16050425920299	0.0242985747340731	miRNATAP	-0.615684884366288	9.14142247953298e-05		NA	NA	NA
hsa-miR-200c-3p	CNTN1	6.47012025883743	2.64500707716408e-26	-2.8506240179562	0.128333090411541	MirTarget;miRNATAP	-0.315621149840789	0.0497185320835011		NA	NA	NA
hsa-miR-200c-3p	CNTN4	6.47012025883743	2.64500707716408e-26	-4.51822232382037	0.000120582389298657	miRNATAP	-0.471522441885607	2.59981820726047e-06		NA	NA	NA
hsa-miR-200c-3p	CREB5	6.47012025883743	2.64500707716408e-26	-1.55239548108621	0.139690196073183	miRNATAP	-0.2309175228535	0.0102400833474917		NA	NA	NA
hsa-miR-200c-3p	CTNND2	6.47012025883743	2.64500707716408e-26	-1.30317562601103	0.308417815380775	MirTarget;miRNATAP	-0.245961430961862	0.0247326605868547		NA	NA	NA
hsa-miR-200c-3p	CYP1B1	6.47012025883743	2.64500707716408e-26	-3.72962588132672	0.00103598214547263	miRNATAP	-0.497408205529593	2.46288631919149e-07	25860934	Loss of miR 200c up regulates CYP1B1 and confers docetaxel resistance in renal cell carcinoma; Additionally miR-200c which is significantly down-regulated in RCC regulates CYP1B1 expression and activity; An inverse association was also observed between the expression levels of miR-200c and CYP1B1 protein in RCC tissues; Restoration of docetaxel resistance by exogenous expression of CYP1B1 in miR-200c-over-expressing cells indicates that CYP1B1 is a functional target of miR-200c; These results suggest that CYP1B1 up-regulation mediated by low miR-200c is one of the mechanisms underlying resistance of RCC cells to docetaxel; Therefore expression of CYP1B1 and miR-200c in RCC may be useful as a prediction for docetaxel response	drug resistance	kidney renal cell cancer
hsa-miR-200c-3p	CYTH3	6.47012025883743	2.64500707716408e-26	-1.4549734725687	0.00123477304703255	MirTarget	-0.141835316685997	0.000226715870882542		NA	NA	NA
hsa-miR-200c-3p	DACT1	6.47012025883743	2.64500707716408e-26	-3.3724949271607	0.00113281420676785	miRNATAP	-0.474491739937372	6.12627091264792e-08		NA	NA	NA
hsa-miR-200c-3p	DDIT4L	6.47012025883743	2.64500707716408e-26	-4.36299610166783	0.00321477559495955	MirTarget	-0.292172761150777	0.021980655562321		NA	NA	NA
hsa-miR-200c-3p	DIXDC1	6.47012025883743	2.64500707716408e-26	-4.24415941146719	1.24306330392779e-10	MirTarget	-0.353592604761699	4.47380227953535e-10		NA	NA	NA
hsa-miR-200c-3p	DLC1	6.47012025883743	2.64500707716408e-26	-3.66271297046991	8.65727517947362e-07	miRNATAP	-0.386976097352615	9.21849256423053e-10		NA	NA	NA
hsa-miR-200c-3p	DMD	6.47012025883743	2.64500707716408e-26	-4.17977171479125	0.00037283808625733	miRNATAP	-0.28173848896209	0.00540254454581762		NA	NA	NA
hsa-miR-200c-3p	DNAJB5	6.47012025883743	2.64500707716408e-26	-2.36670959981668	0.000173814687305954	miRNATAP	-0.262201490555372	1.02025422901768e-06		NA	NA	NA
hsa-miR-200c-3p	DOCK4	6.47012025883743	2.64500707716408e-26	-2.11104257159399	0.00042966140172098	MirTarget	-0.331545251837473	3.77016361385232e-11		NA	NA	NA
hsa-miR-200c-3p	DRP2	6.47012025883743	2.64500707716408e-26	-1.91240250758769	0.00657941206731193	mirMAP	-0.261201444924473	1.26130654092375e-05		NA	NA	NA
hsa-miR-200c-3p	DTNA	6.47012025883743	2.64500707716408e-26	-4.4409941444297	4.24498853318621e-05	MirTarget	-0.379951492240245	4.53528811258158e-05		NA	NA	NA
hsa-miR-200c-3p	DUSP1	6.47012025883743	2.64500707716408e-26	-2.32150271759423	0.0116270325712639	MirTarget;miRNATAP	-0.192770736593645	0.0147008681259181		NA	NA	NA
hsa-miR-200c-3p	DZIP1	6.47012025883743	2.64500707716408e-26	-2.74309374194839	0.00323493660512733	MirTarget	-0.311418047070293	9.05378687549317e-05		NA	NA	NA
hsa-miR-200c-3p	EDNRA	6.47012025883743	2.64500707716408e-26	-3.86396581658458	1.2253716357431e-05	miRNAWalker2_validate;miRNATAP	-0.479548188974558	1.22281107078253e-10		NA	NA	NA
hsa-miR-200c-3p	ENTPD1	6.47012025883743	2.64500707716408e-26	-1.65448165389233	4.89293666031054e-07	MirTarget;mirMAP	-0.174364585691801	3.39368231396043e-10		NA	NA	NA
hsa-miR-200c-3p	ETS1	6.47012025883743	2.64500707716408e-26	-1.32722784146339	0.0272778960906174	MirTarget;miRNATAP	-0.209867722791062	3.95532142095979e-05		NA	NA	NA
hsa-miR-200c-3p	ETV5	6.47012025883743	2.64500707716408e-26	-1.12620366870412	0.197284495018197	MirTarget;miRNATAP	-0.153736455813165	0.0399301778462555	27276064	Another study suggested that ERM expression was regulated directly by miR-200c and had a critical role in miR-200c suppressing cell migration	cell migration	breast cancer
hsa-miR-200c-3p	F2RL2	6.47012025883743	2.64500707716408e-26	-2.18711919599124	0.0285972764744953	MirTarget	-0.342115715447424	5.70118920152878e-05		NA	NA	NA
hsa-miR-200c-3p	FAM19A2	6.47012025883743	2.64500707716408e-26	-1.96327924586474	0.0244364737911559	MirTarget	-0.185829536509174	0.0130187258177474		NA	NA	NA
hsa-miR-200c-3p	FAT3	6.47012025883743	2.64500707716408e-26	-3.48327918457969	0.015252000190887	MirTarget;miRNATAP	-0.493080682893644	5.51987019676858e-05		NA	NA	NA
hsa-miR-200c-3p	FBLN5	6.47012025883743	2.64500707716408e-26	-4.86226771245185	1.33095462605993e-09	miRNAWalker2_validate;miRTarBase	-0.415830464291299	1.53051300969547e-09		NA	NA	NA
hsa-miR-200c-3p	FGF18	6.47012025883743	2.64500707716408e-26	-3.01542595781322	0.0221151767151304	miRNATAP	-0.259861479583255	0.0216691149135961		NA	NA	NA
hsa-miR-200c-3p	FGF2	6.47012025883743	2.64500707716408e-26	-4.7426237294682	2.88390048531716e-06	mirMAP	-0.509145367686688	3.3797939749436e-09		NA	NA	NA
hsa-miR-200c-3p	FHL1	6.47012025883743	2.64500707716408e-26	-6.4702196823406	5.09476327521356e-10	MirTarget	-0.700838731083137	1.22503641568997e-15		NA	NA	NA
hsa-miR-200c-3p	FKBP14	6.47012025883743	2.64500707716408e-26	-0.600195826396854	0.258866513302457	mirMAP	-0.155455619508866	0.000579199084778214		NA	NA	NA
hsa-miR-200c-3p	FLI1	6.47012025883743	2.64500707716408e-26	-2.51391469228041	0.000170810053582531	MirTarget;miRNATAP	-0.294850358848586	2.07871729673619e-07		NA	NA	NA
hsa-miR-200c-3p	FLNA	6.47012025883743	2.64500707716408e-26	-2.74909594751263	1.93215705156445e-05	miRNAWalker2_validate	-0.288078196729452	1.44623491387617e-07		NA	NA	NA
hsa-miR-200c-3p	FLT1	6.47012025883743	2.64500707716408e-26	-2.50880932627343	2.11545598083473e-05	miRNAWalker2_validate;miRTarBase;MirTarget	-0.219736582761241	1.38560548333365e-05		NA	NA	NA
hsa-miR-200c-3p	FN1	6.47012025883743	2.64500707716408e-26	-1.36144636221369	0.250505962748653	miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP	-0.527098065662119	1.20069978407088e-07		NA	NA	NA
hsa-miR-200c-3p	FOXF1	6.47012025883743	2.64500707716408e-26	-3.07138708711646	9.00634367581174e-05	MirTarget	-0.214184034897512	0.00153397000413562		NA	NA	NA
hsa-miR-200c-3p	FOXK1	6.47012025883743	2.64500707716408e-26	-0.465834645571293	0.329736811197743	miRNATAP	-0.105967092436231	0.00931282793767801		NA	NA	NA
hsa-miR-200c-3p	FOXP1	6.47012025883743	2.64500707716408e-26	-1.09383258135725	0.0188681750746135	mirMAP	-0.113435056769006	0.00438511906196254		NA	NA	NA
hsa-miR-200c-3p	FRMD6	6.47012025883743	2.64500707716408e-26	-1.60821237953985	0.0820702410760675	miRNATAP	-0.318497228385608	5.01705490615743e-05		NA	NA	NA
hsa-miR-200c-3p	FSTL1	6.47012025883743	2.64500707716408e-26	-2.21286155841259	0.0039580105672751	MirTarget	-0.236502542187358	0.000315797242807464		NA	NA	NA
hsa-miR-200c-3p	FYN	6.47012025883743	2.64500707716408e-26	-2.7034719817623	4.90203255667929e-05	miRNATAP	-0.264473261620085	3.33090181572032e-06		NA	NA	NA
hsa-miR-200c-3p	FZD4	6.47012025883743	2.64500707716408e-26	-2.83886953461754	3.72732903465121e-05	mirMAP	-0.233220034337669	8.01322431715165e-05		NA	NA	NA
hsa-miR-200c-3p	GABRB3	6.47012025883743	2.64500707716408e-26	-3.81599758490219	0.0252774349188719	mirMAP	-0.64044583664741	9.75114059703551e-06		NA	NA	NA
hsa-miR-200c-3p	GEM	6.47012025883743	2.64500707716408e-26	-3.67606699359352	4.72058151247075e-06	MirTarget;miRNATAP	-0.330688787908482	1.5445873565411e-06		NA	NA	NA
hsa-miR-200c-3p	GFRA1	6.47012025883743	2.64500707716408e-26	-6.71676086795115	2.48870271326987e-07	mirMAP	-0.918101207281193	1.6641001798481e-17		NA	NA	NA
hsa-miR-200c-3p	GJC1	6.47012025883743	2.64500707716408e-26	-2.92001163442114	0.000785414331230878	MirTarget;miRNATAP	-0.174809064783533	0.0197720188976919		NA	NA	NA
hsa-miR-200c-3p	GLI3	6.47012025883743	2.64500707716408e-26	-1.9309410842947	0.0645030158335637	miRNATAP	-0.439330740831604	6.22921073880638e-07		NA	NA	NA
hsa-miR-200c-3p	GLIS2	6.47012025883743	2.64500707716408e-26	-1.45877248744844	0.0452621132995041	miRNATAP	-0.160372306430396	0.0101553466870972		NA	NA	NA
hsa-miR-200c-3p	GPM6A	6.47012025883743	2.64500707716408e-26	-8.84059407174405	1.11545156178103e-11	miRNATAP	-0.675314147001143	2.07599666453414e-09		NA	NA	NA
hsa-miR-200c-3p	GPR146	6.47012025883743	2.64500707716408e-26	-3.24204339330376	1.4981811726304e-10	miRNATAP	-0.106234807193481	0.017279723347311		NA	NA	NA
hsa-miR-200c-3p	GPRASP2	6.47012025883743	2.64500707716408e-26	-3.06519822209201	1.39829838724573e-07	MirTarget	-0.214671245767348	1.97322651540643e-05		NA	NA	NA
hsa-miR-200c-3p	GREM1	6.47012025883743	2.64500707716408e-26	-1.90177748877488	0.0936801310258417	MirTarget	-0.405948813795272	2.47036834650093e-05		NA	NA	NA
hsa-miR-200c-3p	HCFC2	6.47012025883743	2.64500707716408e-26	-0.948206754038386	0.00434815778523131	miRNATAP	-0.121279689918209	1.64945292614211e-05		NA	NA	NA
hsa-miR-200c-3p	HHIP	6.47012025883743	2.64500707716408e-26	-3.25832572720499	0.0274932440392049	mirMAP	-0.274846669995622	0.030426325341298		NA	NA	NA
hsa-miR-200c-3p	HIVEP3	6.47012025883743	2.64500707716408e-26	1.07527826068888	0.187825944811912	miRNATAP	-0.242895016391104	0.000472939963069497		NA	NA	NA
hsa-miR-200c-3p	HLF	6.47012025883743	2.64500707716408e-26	-4.18397758396876	0.000426403354693301	MirTarget;miRNATAP	-0.340725404223469	0.000845497666448309		NA	NA	NA
hsa-miR-200c-3p	IL6ST	6.47012025883743	2.64500707716408e-26	-0.266389395019744	0.817842594179867	mirMAP	-0.215093638493303	0.0297287129816565		NA	NA	NA
hsa-miR-200c-3p	IRS1	6.47012025883743	2.64500707716408e-26	-2.42818243639528	0.00335633570259511	miRNATAP	-0.327926991247788	3.09985403660766e-06		NA	NA	NA
hsa-miR-200c-3p	ITGA1	6.47012025883743	2.64500707716408e-26	-1.26498040699148	0.088392048220612	MirTarget	-0.204503030574105	0.00123950956879595		NA	NA	NA
hsa-miR-200c-3p	ITPR1	6.47012025883743	2.64500707716408e-26	-3.70425443506097	1.11561643309084e-08	miRNATAP	-0.364865307181095	3.63686972563552e-11		NA	NA	NA
hsa-miR-200c-3p	ITPR2	6.47012025883743	2.64500707716408e-26	-0.344004741933712	0.550732070369287	MirTarget	-0.133718682464233	0.00652096509525488		NA	NA	NA
hsa-miR-200c-3p	JAG1	6.47012025883743	2.64500707716408e-26	0.30392833382371	0.667161126642582	miRNAWalker2_validate	-0.227366368433358	0.000148958094017213		NA	NA	NA
hsa-miR-200c-3p	JAZF1	6.47012025883743	2.64500707716408e-26	-3.33129870532741	1.36253596046008e-08	MirTarget;miRNATAP	-0.288423748176846	9.68034093913837e-09		NA	NA	NA
hsa-miR-200c-3p	JUN	6.47012025883743	2.64500707716408e-26	-1.39678224976456	0.0210065056705043	MirTarget	-0.119095512777692	0.0217712883284784		NA	NA	NA
hsa-miR-200c-3p	KANK1	6.47012025883743	2.64500707716408e-26	-1.88289008892227	0.00218127163945131	MirTarget	-0.210989777942739	5.67684420867331e-05		NA	NA	NA
hsa-miR-200c-3p	KCND2	6.47012025883743	2.64500707716408e-26	-2.7575568771041	0.00594718128613525	MirTarget;miRNATAP	-0.373883204501959	1.16137405581179e-05		NA	NA	NA
hsa-miR-200c-3p	KCTD15	6.47012025883743	2.64500707716408e-26	-0.186105974367814	0.804052250106323	MirTarget;miRNATAP	-0.165201135928022	0.00987793429434626		NA	NA	NA
hsa-miR-200c-3p	KDR	6.47012025883743	2.64500707716408e-26	-3.78753480302955	5.10405108636238e-08	miRNATAP	-0.382297274517525	9.67613306032587e-11	24205206	MiR 200c increases the radiosensitivity of non small cell lung cancer cell line A549 by targeting VEGF VEGFR2 pathway; MiR-200c at the nexus of epithelial-mesenchymal transition EMT is predicted to target VEGFR2; The purpose of this study is to test the hypothesis that regulation of VEGFR2 pathway by miR-200c could modulate the radiosensitivity of cancer cells; Bioinformatic analysis luciferase reporter assays and biochemical assays were carried out to validate VEGFR2 as a direct target of miR-200c; We identified VEGFR2 as a novel target of miR-200c		lung squamous cell cancer
hsa-miR-200c-3p	KIAA0040	6.47012025883743	2.64500707716408e-26	-0.676152728535798	0.206396239335536	MirTarget	-0.114078355300315	0.0125466943973234		NA	NA	NA
hsa-miR-200c-3p	KIAA1462	6.47012025883743	2.64500707716408e-26	-4.21843344330322	1.46499915072858e-09	MirTarget	-0.362404990740333	1.38802396781597e-09		NA	NA	NA
hsa-miR-200c-3p	KIF13A	6.47012025883743	2.64500707716408e-26	-0.768795091455261	0.214525140898378	miRNATAP	-0.103988661199238	0.049867636635376		NA	NA	NA
hsa-miR-200c-3p	KLF9	6.47012025883743	2.64500707716408e-26	-3.69570385779272	1.71840900056727e-08	miRNAWalker2_validate;miRTarBase;miRNATAP	-0.24483741970432	1.64459844697795e-05		NA	NA	NA
hsa-miR-200c-3p	KLHDC1	6.47012025883743	2.64500707716408e-26	-2.41275228600919	0.000251275341657676	MirTarget	-0.182932970212369	0.00124743119239423		NA	NA	NA
hsa-miR-200c-3p	KLHL3	6.47012025883743	2.64500707716408e-26	-2.04135558829045	0.00444293805485006	miRNATAP	-0.179777143775817	0.00349122539275336		NA	NA	NA
hsa-miR-200c-3p	LAMC1	6.47012025883743	2.64500707716408e-26	-1.1345245467724	0.0487516321194313	MirTarget;miRNATAP	-0.105453274620074	0.0325569747442994		NA	NA	NA
hsa-miR-200c-3p	LATS2	6.47012025883743	2.64500707716408e-26	-1.64065240798514	0.000675576860801643	miRNATAP	-0.142079684531404	0.000588434621432939		NA	NA	NA
hsa-miR-200c-3p	LCA5	6.47012025883743	2.64500707716408e-26	-1.85312828811987	0.0069007634094868	MirTarget	-0.12426153113947	0.0351595970979669		NA	NA	NA
hsa-miR-200c-3p	LHFP	6.47012025883743	2.64500707716408e-26	-3.72322745905274	1.33844209793639e-08	MirTarget;miRNATAP	-0.361215681088172	9.47627414095923e-11		NA	NA	NA
hsa-miR-200c-3p	LIX1L	6.47012025883743	2.64500707716408e-26	-2.87521613135102	6.70546349738552e-09	MirTarget	-0.247156418648236	5.95063808282489e-09		NA	NA	NA
hsa-miR-200c-3p	MAF	6.47012025883743	2.64500707716408e-26	-1.67642643216486	0.0648843975805926	miRNATAP	-0.278681449219642	0.000315320615768877		NA	NA	NA
hsa-miR-200c-3p	MARCH1	6.47012025883743	2.64500707716408e-26	1.3183736776439	0.0435700403061794	MirTarget	-0.147583259051473	0.00829553193131831		NA	NA	NA
hsa-miR-200c-3p	MARCH8	6.47012025883743	2.64500707716408e-26	-0.89580428142125	0.185515939584244	MirTarget	-0.158559243057284	0.00606423758334442		NA	NA	NA
hsa-miR-200c-3p	MBNL2	6.47012025883743	2.64500707716408e-26	-1.12233809482155	0.0459066411907178	miRNATAP	-0.118534463731954	0.0137699781800238		NA	NA	NA
hsa-miR-200c-3p	MEF2D	6.47012025883743	2.64500707716408e-26	-1.60022304030769	2.0684160611841e-07	mirMAP	-0.11777925631775	8.40688872053535e-06		NA	NA	NA
hsa-miR-200c-3p	MEGF10	6.47012025883743	2.64500707716408e-26	-3.63056720354056	0.000582639883483001	MirTarget	-0.3725195347424	3.66886063607833e-05		NA	NA	NA
hsa-miR-200c-3p	MEX3B	6.47012025883743	2.64500707716408e-26	-1.907958105692	0.0200623303361945	miRNATAP	-0.230222802346263	0.00102734946698581		NA	NA	NA
hsa-miR-200c-3p	MFAP5	6.47012025883743	2.64500707716408e-26	-6.02112429395012	0.00031991851708567	miRNATAP	-0.544156350624235	0.000150370227131591		NA	NA	NA
hsa-miR-200c-3p	MITF	6.47012025883743	2.64500707716408e-26	-4.45139814765382	6.62549661759329e-10	miRNATAP	-0.299301868172581	1.75377873530351e-06		NA	NA	NA
hsa-miR-200c-3p	MPDZ	6.47012025883743	2.64500707716408e-26	-3.47754890216954	0.000677696629805922	MirTarget	-0.232884376823939	0.00827351781888252		NA	NA	NA
hsa-miR-200c-3p	MPRIP	6.47012025883743	2.64500707716408e-26	-1.56361211612266	5.52507002193216e-05	MirTarget;miRNATAP	-0.106288230414394	0.00142879564765599		NA	NA	NA
hsa-miR-200c-3p	MRVI1	6.47012025883743	2.64500707716408e-26	-4.87730792862913	1.65805096076273e-10	MirTarget	-0.519672737308513	5.93447120709013e-16		NA	NA	NA
hsa-miR-200c-3p	MSN	6.47012025883743	2.64500707716408e-26	-0.62674647675537	0.390167415436277	miRNAWalker2_validate;miRTarBase;MirTarget	-0.321345862085297	1.54777337357093e-07		NA	NA	NA
hsa-miR-200c-3p	MSRB3	6.47012025883743	2.64500707716408e-26	-5.12134814852364	2.69870314210263e-08	mirMAP	-0.513729579838886	5.3747212419056e-11		NA	NA	NA
hsa-miR-200c-3p	MTSS1L	6.47012025883743	2.64500707716408e-26	-0.878113736694936	0.108688688962147	miRNATAP	-0.10131072949052	0.0305765880739815		NA	NA	NA
hsa-miR-200c-3p	MYO5A	6.47012025883743	2.64500707716408e-26	-0.133030035892503	0.844074517488657	mirMAP	-0.212961253578984	0.000206375034283799		NA	NA	NA
hsa-miR-200c-3p	NALCN	6.47012025883743	2.64500707716408e-26	-2.96900446210743	0.0245973927525346	MirTarget	-0.400347075803386	0.000384615238056382		NA	NA	NA
hsa-miR-200c-3p	NAP1L5	6.47012025883743	2.64500707716408e-26	-2.41159783659587	0.00106634000924495	MirTarget;miRNATAP	-0.139583462740228	0.0280436806406965		NA	NA	NA
hsa-miR-200c-3p	NCAM1	6.47012025883743	2.64500707716408e-26	-7.27033620647047	1.60252013841234e-13	miRTarBase	-0.540439960575067	2.69102010482828e-10		NA	NA	NA
hsa-miR-200c-3p	NCS1	6.47012025883743	2.64500707716408e-26	-1.4515534101495	0.0160858802426688	miRNATAP	-0.248967045963907	1.03601447860477e-06		NA	NA	NA
hsa-miR-200c-3p	NDN	6.47012025883743	2.64500707716408e-26	-5.07390710235974	1.70787649675861e-10	MirTarget;miRNATAP	-0.459194559205779	1.37577730641789e-11		NA	NA	NA
hsa-miR-200c-3p	NDST1	6.47012025883743	2.64500707716408e-26	-0.180694031901035	0.708003888406229	miRNATAP	-0.132268148873171	0.00125077398075564		NA	NA	NA
hsa-miR-200c-3p	NEGR1	6.47012025883743	2.64500707716408e-26	-5.44789313937809	2.41819782942133e-07	miRNATAP	-0.514861091396306	1.12304501689442e-08		NA	NA	NA
hsa-miR-200c-3p	NEK9	6.47012025883743	2.64500707716408e-26	-1.0163727215697	0.000362328868506925	MirTarget	-0.105193649404319	1.3377282125954e-05		NA	NA	NA
hsa-miR-200c-3p	NFASC	6.47012025883743	2.64500707716408e-26	-2.43145916830151	0.0259317090720814	miRNATAP	-0.464630284589045	4.68601017195164e-07	23185507	miR 200c targets a NF κB up regulated TrkB/NTF3 autocrine signaling loop to enhance anoikis sensitivity in triple negative breast cancer		breast cancer
hsa-miR-200c-3p	NFIA	6.47012025883743	2.64500707716408e-26	-0.821609437910618	0.18121112770223	MirTarget;miRNATAP	-0.124003650379887	0.0182722084696979		NA	NA	NA
hsa-miR-200c-3p	NLGN4X	6.47012025883743	2.64500707716408e-26	-3.16125360101453	0.0508118994850833	miRNATAP	-0.478863073282079	0.00052616534710615		NA	NA	NA
hsa-miR-200c-3p	NOVA1	6.47012025883743	2.64500707716408e-26	-6.30046281080199	2.82021365108925e-07	MirTarget;miRNATAP	-0.688123463760265	3.52112021455275e-11		NA	NA	NA
hsa-miR-200c-3p	NR2F2	6.47012025883743	2.64500707716408e-26	-3.23341028635531	2.19815270289758e-05	miRNATAP	-0.18300083789705	0.00551217949930412		NA	NA	NA
hsa-miR-200c-3p	NR5A2	6.47012025883743	2.64500707716408e-26	-3.49575948592341	3.75399384792398e-06	miRNATAP	-0.293213057510647	6.2876277671e-06		NA	NA	NA
hsa-miR-200c-3p	NRIP1	6.47012025883743	2.64500707716408e-26	0.19999841049611	0.713428464989279	MirTarget;miRNATAP	-0.10816109965001	0.0199729851728971		NA	NA	NA
hsa-miR-200c-3p	NRIP3	6.47012025883743	2.64500707716408e-26	0.135804002942371	0.876701650985585	mirMAP	-0.174402369340376	0.0197432067474836		NA	NA	NA
hsa-miR-200c-3p	NTF3	6.47012025883743	2.64500707716408e-26	-3.48574436830551	0.00527602357381811	miRNAWalker2_validate;miRNATAP	-0.267305642123698	0.0128591951961541		NA	NA	NA
hsa-miR-200c-3p	NTRK2	6.47012025883743	2.64500707716408e-26	-1.54248853110693	0.400878993948488	miRNAWalker2_validate;miRTarBase	-0.454168801324507	0.00376453070732347	23209748;23074172	miR 200c sensitizes breast cancer cells to doxorubicin treatment by decreasing TrkB and Bmi1 expression;miR-200c also targets TrkB a mediator of resistance to anoikis	;drug resistance	breast cancer;ovarian cancer
hsa-miR-200c-3p	OSR1	6.47012025883743	2.64500707716408e-26	-3.73179382502437	0.00161053592167348	miRNATAP	-0.224486579018349	0.0278001675181878		NA	NA	NA
hsa-miR-200c-3p	OSTM1	6.47012025883743	2.64500707716408e-26	-1.02726470769602	0.0035410552805802	MirTarget	-0.144381606754637	1.198982675558e-06		NA	NA	NA
hsa-miR-200c-3p	PALM2-AKAP2	6.47012025883743	2.64500707716408e-26	-3.06238169861873	2.95962701675291e-06	miRNATAP	-0.305842896114956	4.32607367167947e-08		NA	NA	NA
hsa-miR-200c-3p	PAM	6.47012025883743	2.64500707716408e-26	-2.0988433486132	0.000121460186299677	miRNATAP	-0.14437512345728	0.00213670660943815		NA	NA	NA
hsa-miR-200c-3p	PCDH10	6.47012025883743	2.64500707716408e-26	-4.02506493515044	0.00207573496528642	MirTarget	-0.410999079753371	0.000240004532448457		NA	NA	NA
hsa-miR-200c-3p	PCDH8	6.47012025883743	2.64500707716408e-26	-2.04173881346717	0.229076558288945	miRNATAP	-0.481458307755227	0.000876420044990663		NA	NA	NA
hsa-miR-200c-3p	PCSK2	6.47012025883743	2.64500707716408e-26	-5.03879531694342	0.000264067314248769	miRNATAP	-0.373089250480723	0.00171146815001149		NA	NA	NA
hsa-miR-200c-3p	PDE10A	6.47012025883743	2.64500707716408e-26	-2.26684634808676	0.0660741440592912	mirMAP	-0.303774124753702	0.00398698953836319		NA	NA	NA
hsa-miR-200c-3p	PDE5A	6.47012025883743	2.64500707716408e-26	-2.38746227006165	0.000716413504424858	miRNATAP	-0.127332734914728	0.0365372802959883		NA	NA	NA
hsa-miR-200c-3p	PDE7B	6.47012025883743	2.64500707716408e-26	-4.29424253758039	8.18621058906608e-08	miRNATAP	-0.399850828912745	5.10690424888699e-09		NA	NA	NA
hsa-miR-200c-3p	PHACTR2	6.47012025883743	2.64500707716408e-26	-1.20309955473489	0.00845348018819827	MirTarget;miRNATAP	-0.11831560677707	0.0024499121729224		NA	NA	NA
hsa-miR-200c-3p	PHEX	6.47012025883743	2.64500707716408e-26	-0.82317683514734	0.473663408286219	MirTarget	-0.25717822870116	0.0087890860685634		NA	NA	NA
hsa-miR-200c-3p	PHF21B	6.47012025883743	2.64500707716408e-26	-4.95423671953445	0.000153207248445739	MirTarget	-0.43353705324965	0.000113802315046582		NA	NA	NA
hsa-miR-200c-3p	PHLDB1	6.47012025883743	2.64500707716408e-26	-2.20900839876571	0.000317999124005285	MirTarget;miRNATAP	-0.184663998295304	0.000452798835540723		NA	NA	NA
hsa-miR-200c-3p	PIK3R1	6.47012025883743	2.64500707716408e-26	-1.85375256159008	0.0127438113463991	mirMAP	-0.209884750055895	0.000971059963262446		NA	NA	NA
hsa-miR-200c-3p	PLCL1	6.47012025883743	2.64500707716408e-26	-4.3220561926702	1.13083584512049e-08	MirTarget	-0.497191096741011	4.83484210319897e-15		NA	NA	NA
hsa-miR-200c-3p	PLK2	6.47012025883743	2.64500707716408e-26	-0.350017013516764	0.674788788291004	miRNATAP	-0.180778621931832	0.0111658865295401		NA	NA	NA
hsa-miR-200c-3p	PLXNA4	6.47012025883743	2.64500707716408e-26	-3.99749568962178	0.000771713189722976	miRNATAP	-0.414126746697103	4.6232387427979e-05		NA	NA	NA
hsa-miR-200c-3p	PLXNC1	6.47012025883743	2.64500707716408e-26	-0.705833742044138	0.545902978988465	miRNATAP	-0.410325846976838	3.41260168180489e-05		NA	NA	NA
hsa-miR-200c-3p	PPM1F	6.47012025883743	2.64500707716408e-26	-1.23992186817192	0.00296278064989874	miRNAWalker2_validate;MirTarget;miRNATAP	-0.217495124057734	4.38139349340462e-10	22144583	MicroRNA 200c represses migration and invasion of breast cancer cells by targeting actin regulatory proteins FHOD1 and PPM1F; We identified FHOD1 and PPM1F direct regulators of the actin cytoskeleton as novel targets of miR-200c; Remarkably expression levels of FHOD1 and PPM1F were inversely correlated with the level of miR-200c in breast cancer cell lines breast cancer patient samples and 58 cancer cell lines of various origins		breast cancer
hsa-miR-200c-3p	PPP2R2C	6.47012025883743	2.64500707716408e-26	-2.54177583085932	0.149641186912383	miRNATAP	-0.449989786928302	0.00282829298525296		NA	NA	NA
hsa-miR-200c-3p	PRDM1	6.47012025883743	2.64500707716408e-26	0.0939045675967058	0.886425550695362	miRNATAP	-0.111957378771612	0.0464423792788125		NA	NA	NA
hsa-miR-200c-3p	PRKACB	6.47012025883743	2.64500707716408e-26	-1.46896806095161	0.00691161548744777	MirTarget;miRNATAP	-0.145130591541329	0.00181365494045828		NA	NA	NA
hsa-miR-200c-3p	PRKAR2B	6.47012025883743	2.64500707716408e-26	-2.78794723692538	0.0026756054188432	miRNATAP	-0.232410940316261	0.00356398855766406		NA	NA	NA
hsa-miR-200c-3p	PRKCA	6.47012025883743	2.64500707716408e-26	-2.51484065178579	0.000301846026330391	miRNATAP	-0.227644911192639	0.000134967313056447		NA	NA	NA
hsa-miR-200c-3p	PRKCB	6.47012025883743	2.64500707716408e-26	-1.37779465994896	0.125783325051528	MirTarget;miRNATAP	-0.348745791831867	4.59454351785762e-06		NA	NA	NA
hsa-miR-200c-3p	PRKG1	6.47012025883743	2.64500707716408e-26	-4.14478022055911	0.000346396361233345	miRNATAP	-0.60078601717453	7.15419754813599e-10		NA	NA	NA
hsa-miR-200c-3p	PRTG	6.47012025883743	2.64500707716408e-26	-4.74035707383511	5.79013562364823e-05	miRNATAP	-0.492626275884265	9.734227497189e-07		NA	NA	NA
hsa-miR-200c-3p	PSD3	6.47012025883743	2.64500707716408e-26	-0.677914428495742	0.350325961994988	MirTarget;mirMAP;miRNATAP	-0.179645280009827	0.00370906342563686		NA	NA	NA
hsa-miR-200c-3p	PTPN13	6.47012025883743	2.64500707716408e-26	0.294771516623788	0.739722308879297	miRNAWalker2_validate;miRTarBase	-0.157780087828871	0.037667455919745		NA	NA	NA
hsa-miR-200c-3p	PTPN21	6.47012025883743	2.64500707716408e-26	-1.40931684065664	0.00154181930922701	miRNATAP	-0.118289246395182	0.00191504152753466		NA	NA	NA
hsa-miR-200c-3p	PTPRD	6.47012025883743	2.64500707716408e-26	-5.46044460487346	0.00016227548373706	miRNAWalker2_validate	-0.635354452318971	2.46190452346783e-07		NA	NA	NA
hsa-miR-200c-3p	PYGO1	6.47012025883743	2.64500707716408e-26	-2.44710213372309	0.0639646847724574	mirMAP	-0.328322913697804	0.00366717570964443		NA	NA	NA
hsa-miR-200c-3p	RAB11FIP2	6.47012025883743	2.64500707716408e-26	-2.40383301883775	2.3729959132263e-11	MirTarget;miRNATAP	-0.172798485882263	2.74230270085168e-08		NA	NA	NA
hsa-miR-200c-3p	RAB8B	6.47012025883743	2.64500707716408e-26	-1.19782846334847	0.00146439299102655	mirMAP;miRNATAP	-0.159269333832142	5.51207964557748e-07		NA	NA	NA
hsa-miR-200c-3p	RAP2C	6.47012025883743	2.64500707716408e-26	-0.963123560669377	0.0108848030318949	MirTarget;miRNATAP	-0.155545642776566	1.07715117890767e-06		NA	NA	NA
hsa-miR-200c-3p	RASSF2	6.47012025883743	2.64500707716408e-26	-1.84693151665047	0.00526283577521879	miRNAWalker2_validate	-0.328761284266132	3.24608790353016e-09		NA	NA	NA
hsa-miR-200c-3p	RASSF8	6.47012025883743	2.64500707716408e-26	-3.1188523283351	0.000151262443971379	miRNATAP	-0.146330480422942	0.0399611001191934		NA	NA	NA
hsa-miR-200c-3p	RBM20	6.47012025883743	2.64500707716408e-26	-2.1491748395042	0.0771599205431781	MirTarget	-0.238594838707177	0.0221061153744374		NA	NA	NA
hsa-miR-200c-3p	RECK	6.47012025883743	2.64500707716408e-26	-4.28782478538832	5.46316347444686e-08	miRNATAP	-0.536671939774126	3.22939236580011e-16	27574450;24647918	MiR 200c promotes bladder cancer cell migration and invasion by directly targeting RECK; The luciferase reporter assay showed that RECK was a direct target of miR-200c;Finally we demonstrated that expression of miR-200c in H460 cells suppressed cell growth by targeting RECK followed by activation of the JNK signaling pathway and ER stress; Collectively these data show that miR-200c expression sensitizes H460 cells to RESV and this is likely due to RECK expression	cell migration;	bladder cancer;lung cancer
hsa-miR-200c-3p	RELN	6.47012025883743	2.64500707716408e-26	-4.56675081618191	0.00128745672091879	MirTarget	-0.467982105834413	0.000116086212043485		NA	NA	NA
hsa-miR-200c-3p	RFTN2	6.47012025883743	2.64500707716408e-26	-3.02849389208693	1.37688585695274e-06	MirTarget	-0.273199280087174	3.60266549875008e-07		NA	NA	NA
hsa-miR-200c-3p	RGL1	6.47012025883743	2.64500707716408e-26	-2.1168474173652	0.000359383480276991	MirTarget;miRNATAP	-0.266088067783328	1.18774605161995e-07		NA	NA	NA
hsa-miR-200c-3p	RIN2	6.47012025883743	2.64500707716408e-26	-0.328624378302318	0.467528616545553	miRNAWalker2_validate	-0.120781816392807	0.00167875088084308		NA	NA	NA
hsa-miR-200c-3p	RNF38	6.47012025883743	2.64500707716408e-26	-1.27558790842721	5.0283236501622e-05	MirTarget;miRNATAP	-0.109244794425757	4.71288657514708e-05		NA	NA	NA
hsa-miR-200c-3p	RPS6KA2	6.47012025883743	2.64500707716408e-26	-2.65030014005572	0.000604235142902453	miRNATAP	-0.185226101150327	0.005371700638205		NA	NA	NA
hsa-miR-200c-3p	RUSC2	6.47012025883743	2.64500707716408e-26	-2.30859670656505	1.38847444083379e-06	miRNATAP	-0.172975788829819	2.64011161796328e-05		NA	NA	NA
hsa-miR-200c-3p	SASH1	6.47012025883743	2.64500707716408e-26	-1.00561553511658	0.0624707747380935	MirTarget	-0.103547128326134	0.0250528217783149		NA	NA	NA
hsa-miR-200c-3p	SCN2A	6.47012025883743	2.64500707716408e-26	-1.67698295494461	0.364163960938173	MirTarget;miRNATAP	-0.362316939864991	0.0219963858357387		NA	NA	NA
hsa-miR-200c-3p	SCN3A	6.47012025883743	2.64500707716408e-26	-3.01591468571821	0.00670485854462323	mirMAP	-0.415248615366241	1.13862385034924e-05		NA	NA	NA
hsa-miR-200c-3p	SCN5A	6.47012025883743	2.64500707716408e-26	-2.48916903249726	0.0179722318283197	miRNATAP	-0.26133629689935	0.00373590019450882		NA	NA	NA
hsa-miR-200c-3p	SDC2	6.47012025883743	2.64500707716408e-26	-3.48496703171104	0.000178061797352628	miRNATAP	-0.350366467118006	1.04074763024558e-05		NA	NA	NA
hsa-miR-200c-3p	SEC23A	6.47012025883743	2.64500707716408e-26	-1.11132920093232	0.00318125901449351	MirTarget;miRNATAP	-0.155899677760209	9.61657475797632e-07	21593139	A computational analysis predicted the 3'-UTR of the SEC23A gene as a potential target for both miR-375 and miR-200c; Here we show that the 3'-UTR of SEC23A mRNA is indeed a target for miR-375 and miR-200c and that both miRNAs downregulate Sec23A protein expression when ectopically expressed in human 293T cells; In primary samples of CaP we found a direct correlation between reduction of SEC23A mRNA and overexpression of miR-375 but not of miR-200c		prostate cancer
hsa-miR-200c-3p	SEMA6D	6.47012025883743	2.64500707716408e-26	-2.20177832413999	0.0862979259770274	miRNATAP	-0.318278406212089	0.00373481127298918		NA	NA	NA
hsa-miR-200c-3p	SEPT7	6.47012025883743	2.64500707716408e-26	-0.908787785166763	0.000547602743138797	miRNAWalker2_validate	-0.101190664212694	5.21354197876974e-06		NA	NA	NA
hsa-miR-200c-3p	SERINC1	6.47012025883743	2.64500707716408e-26	-1.78739802682163	8.91900260790256e-09	MirTarget;miRNATAP	-0.103316287900782	0.000123941961070085		NA	NA	NA
hsa-miR-200c-3p	SESN1	6.47012025883743	2.64500707716408e-26	-1.78011230018704	6.12493041347409e-05	MirTarget;miRNATAP	-0.112372276298621	0.00331320290805762	24791940	We found that miR-200c overexpression increased cellular radiosensitivity by direct regulation of the oxidative stress response genes PRDX2 GAPB/Nrf2 and SESN1 in ways that inhibits DNA double-strand breaks repair increase levels of reactive oxygen species and upregulate p21	drug resistance	lung cancer
hsa-miR-200c-3p	SESN3	6.47012025883743	2.64500707716408e-26	-0.383534957105207	0.69604184723725	MirTarget	-0.222251723022918	0.00801686722592441		NA	NA	NA
hsa-miR-200c-3p	SFMBT2	6.47012025883743	2.64500707716408e-26	-1.49908117039167	0.119418935978856	mirMAP	-0.375389618476421	3.99752826999381e-06		NA	NA	NA
hsa-miR-200c-3p	SGCD	6.47012025883743	2.64500707716408e-26	-4.54262936780335	0.000169922663050445	mirMAP	-0.458913256571874	8.86666381359416e-06		NA	NA	NA
hsa-miR-200c-3p	SGIP1	6.47012025883743	2.64500707716408e-26	-2.18475545881069	0.00755388449061642	MirTarget	-0.3895640785862	1.4943288496287e-08		NA	NA	NA
hsa-miR-200c-3p	SGPP1	6.47012025883743	2.64500707716408e-26	-0.989589765875607	0.209372628975208	MirTarget	-0.141617727006824	0.0359212305000563		NA	NA	NA
hsa-miR-200c-3p	SHC1	6.47012025883743	2.64500707716408e-26	-0.0905023828063758	0.821762372481086	miRNAWalker2_validate;miRNATAP	-0.11196651448805	0.00101570662036496		NA	NA	NA
hsa-miR-200c-3p	SHE	6.47012025883743	2.64500707716408e-26	-3.680365549955	0.000191992406750442	mirMAP	-0.439728986932291	1.5463432235597e-07		NA	NA	NA
hsa-miR-200c-3p	SHROOM4	6.47012025883743	2.64500707716408e-26	-2.05440419969342	0.0148757283652817	mirMAP	-0.308199311713782	1.71003297666728e-05		NA	NA	NA
hsa-miR-200c-3p	SIRPA	6.47012025883743	2.64500707716408e-26	-0.192181621402275	0.793659824530169	MirTarget	-0.227251060736523	0.000269469610375052		NA	NA	NA
hsa-miR-200c-3p	SLC14A1	6.47012025883743	2.64500707716408e-26	-2.15537410236363	0.0688825193772628	miRNATAP	-0.235455107164791	0.0204564330988927		NA	NA	NA
hsa-miR-200c-3p	SLC16A2	6.47012025883743	2.64500707716408e-26	-2.54993025447742	0.0126293930218215	miRNATAP	-0.476186910895051	3.16592313947576e-08		NA	NA	NA
hsa-miR-200c-3p	SLC23A2	6.47012025883743	2.64500707716408e-26	-0.932243926078394	0.0333910027677933	miRNATAP	-0.122792951402979	0.00100323010234348		NA	NA	NA
hsa-miR-200c-3p	SLC30A4	6.47012025883743	2.64500707716408e-26	-0.331091186907675	0.628347553960278	mirMAP	-0.127490345562107	0.0292262473091384		NA	NA	NA
hsa-miR-200c-3p	SLC35B4	6.47012025883743	2.64500707716408e-26	-0.586351545913272	0.0782010908501957	MirTarget	-0.131257885360482	2.75496707690194e-06		NA	NA	NA
hsa-miR-200c-3p	SLC38A4	6.47012025883743	2.64500707716408e-26	-2.0101437359495	0.162318834432143	miRNATAP	-0.54123427052395	8.8422888836581e-06		NA	NA	NA
hsa-miR-200c-3p	SLC6A1	6.47012025883743	2.64500707716408e-26	-3.05638630867532	0.000554626267307082	MirTarget;miRNATAP	-0.440288717648609	3.58903270906144e-09		NA	NA	NA
hsa-miR-200c-3p	SNAI2	6.47012025883743	2.64500707716408e-26	-1.63105031719645	0.151947151729511	miRNATAP	-0.366231228387546	0.000154734539121361		NA	NA	NA
hsa-miR-200c-3p	SNAP25	6.47012025883743	2.64500707716408e-26	-4.08063911345584	0.00264007465756078	MirTarget;miRNATAP	-0.354062506410651	0.00238187873896826		NA	NA	NA
hsa-miR-200c-3p	SPRED1	6.47012025883743	2.64500707716408e-26	-1.20771019802783	0.00430481333608872	miRNATAP	-0.151820076292416	2.37878276088673e-05		NA	NA	NA
hsa-miR-200c-3p	ST3GAL2	6.47012025883743	2.64500707716408e-26	-1.82116913003779	2.0100455842577e-05	MirTarget;miRNATAP	-0.216701199628863	1.81964890021464e-09		NA	NA	NA
hsa-miR-200c-3p	ST6GAL2	6.47012025883743	2.64500707716408e-26	-2.257605369786	0.0781882276295061	mirMAP	-0.421161751475823	0.000112248297390776		NA	NA	NA
hsa-miR-200c-3p	STARD8	6.47012025883743	2.64500707716408e-26	-3.36381364678495	2.40646928385738e-08	mirMAP	-0.405359646975025	8.01387988151299e-16		NA	NA	NA
hsa-miR-200c-3p	SULF1	6.47012025883743	2.64500707716408e-26	-1.18113811961141	0.222780303266628	MirTarget;miRNATAP	-0.360488305548038	1.09842699234066e-05		NA	NA	NA
hsa-miR-200c-3p	SV2B	6.47012025883743	2.64500707716408e-26	-2.05886345743427	0.106689040731223	mirMAP	-0.303841279662904	0.00537602559376125		NA	NA	NA
hsa-miR-200c-3p	SYDE1	6.47012025883743	2.64500707716408e-26	-2.73422804199318	0.000797548057676696	MirTarget;miRNATAP	-0.33750733799032	1.10556010223901e-06		NA	NA	NA
hsa-miR-200c-3p	SYNC	6.47012025883743	2.64500707716408e-26	-2.34330197802536	0.0609083259425116	MirTarget	-0.288661481387845	0.0070112376600782		NA	NA	NA
hsa-miR-200c-3p	SYT1	6.47012025883743	2.64500707716408e-26	-5.26036758097741	0.00105227161276887	MirTarget;miRNATAP	-0.344569585272886	0.0128067567180787		NA	NA	NA
hsa-miR-200c-3p	SYT11	6.47012025883743	2.64500707716408e-26	-3.43609270126513	2.66041213521335e-07	mirMAP	-0.345916289239781	1.12499262585804e-09		NA	NA	NA
hsa-miR-200c-3p	TBX18	6.47012025883743	2.64500707716408e-26	-1.77367755407136	0.39423688521135	MirTarget	-0.412320828282902	0.02066773595821		NA	NA	NA
hsa-miR-200c-3p	TCF4	6.47012025883743	2.64500707716408e-26	-2.23433165372064	0.00194262002575201	mirMAP;miRNATAP	-0.25143745636959	4.36153655385987e-05		NA	NA	NA
hsa-miR-200c-3p	TCP11L1	6.47012025883743	2.64500707716408e-26	-0.308888724098123	0.534879370589562	MirTarget	-0.107640384613073	0.0112041109554204		NA	NA	NA
hsa-miR-200c-3p	TFEC	6.47012025883743	2.64500707716408e-26	1.26240633687076	0.158826021061427	MirTarget	-0.245108964025473	0.00133548298273867		NA	NA	NA
hsa-miR-200c-3p	TFPI	6.47012025883743	2.64500707716408e-26	-2.99865686822915	0.00698823320919658	MirTarget	-0.215777673306079	0.0240549902876771		NA	NA	NA
hsa-miR-200c-3p	THRA	6.47012025883743	2.64500707716408e-26	-2.81473866933756	1.85535002449113e-09	mirMAP	-0.169273959646639	3.23540889878225e-05		NA	NA	NA
hsa-miR-200c-3p	TIMP2	6.47012025883743	2.64500707716408e-26	-3.59794494522838	2.10429352476442e-07	miRTarBase	-0.407824446555903	3.01880203041024e-12		NA	NA	NA
hsa-miR-200c-3p	TLN1	6.47012025883743	2.64500707716408e-26	-1.69309268157312	1.12927629704341e-07	miRNATAP	-0.184119439610688	6.81566389819943e-12		NA	NA	NA
hsa-miR-200c-3p	TLN2	6.47012025883743	2.64500707716408e-26	-1.44860907717541	0.0444390016311859	miRNATAP	-0.136336028166196	0.0273891480236767		NA	NA	NA
hsa-miR-200c-3p	TMEM43	6.47012025883743	2.64500707716408e-26	-1.33845768171733	0.000183832694314726	MirTarget	-0.152920322721576	4.49861698325332e-07		NA	NA	NA
hsa-miR-200c-3p	TRAM1L1	6.47012025883743	2.64500707716408e-26	-3.50657823950594	0.00226300750724642	MirTarget;miRNATAP	-0.349873012293866	0.000374939693579546		NA	NA	NA
hsa-miR-200c-3p	TRHDE	6.47012025883743	2.64500707716408e-26	-5.36984249731735	0.000470493331087257	MirTarget	-0.649760772399373	6.47732689225381e-07		NA	NA	NA
hsa-miR-200c-3p	TRIL	6.47012025883743	2.64500707716408e-26	-2.04685940357468	0.0791263282500526	MirTarget	-0.41608331302924	2.60594849492216e-05		NA	NA	NA
hsa-miR-200c-3p	VASH1	6.47012025883743	2.64500707716408e-26	-0.917164494819347	0.0963184146908343	MirTarget;miRNATAP	-0.253443755810345	4.26019022502806e-08		NA	NA	NA
hsa-miR-200c-3p	VAT1L	6.47012025883743	2.64500707716408e-26	-3.11238247729384	0.00744662175909513	MirTarget;miRNATAP	-0.486096476957685	8.0103781622939e-07		NA	NA	NA
hsa-miR-200c-3p	VGLL3	6.47012025883743	2.64500707716408e-26	-3.67857910192456	0.00250435275558057	mirMAP	-0.34579614195765	0.000921080360071236		NA	NA	NA
hsa-miR-200c-3p	WASF3	6.47012025883743	2.64500707716408e-26	-2.83975078195081	0.0107635104996704	miRNATAP	-0.419645019455589	9.18056415535885e-06		NA	NA	NA
hsa-miR-200c-3p	WDR91	6.47012025883743	2.64500707716408e-26	0.773700856092556	0.181898929895563	MirTarget	-0.107533271819569	0.0300925575769533		NA	NA	NA
hsa-miR-200c-3p	WIPF1	6.47012025883743	2.64500707716408e-26	-1.3199372564298	0.0475876731819671	MirTarget;miRNATAP	-0.270239604564852	1.57518771534792e-06		NA	NA	NA
hsa-miR-200c-3p	XKR6	6.47012025883743	2.64500707716408e-26	0.111282891500067	0.922180948731624	miRNATAP	-0.306177625628666	0.00160486748808227		NA	NA	NA
hsa-miR-200c-3p	YAP1	6.47012025883743	2.64500707716408e-26	-0.717460133341563	0.36094816300211	MirTarget	-0.138813416618053	0.0389104444590292		NA	NA	NA
hsa-miR-200c-3p	ZC3H12B	6.47012025883743	2.64500707716408e-26	-3.5557136877298	1.55525144024858e-08	mirMAP	-0.25833245080383	1.98862743061865e-06		NA	NA	NA
hsa-miR-200c-3p	ZC3H6	6.47012025883743	2.64500707716408e-26	-1.39996693247178	0.0013964734780245	MirTarget;miRNATAP	-0.110298435957103	0.00331750488395284		NA	NA	NA
hsa-miR-200c-3p	ZCCHC24	6.47012025883743	2.64500707716408e-26	-4.22525928068511	2.98299090136584e-13	MirTarget;miRNATAP	-0.450120821010846	1.34321524927686e-20		NA	NA	NA
hsa-miR-200c-3p	ZDHHC15	6.47012025883743	2.64500707716408e-26	-4.93284359218268	0.000429826485965628	MirTarget	-0.482200261962873	5.83026879096635e-05		NA	NA	NA
hsa-miR-200c-3p	ZEB1	6.47012025883743	2.64500707716408e-26	-4.15148040615949	1.11507739514902e-09	miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP	-0.480321526877672	3.14204853907128e-17	27666124;24710933;23754305;24615544;24424572;24186205;21682933;22407310;27717206;23626803	miR 200c regulates crizotinib resistant ALK positive lung cancer cells by reversing epithelial mesenchymal transition via targeting ZEB1;miR-200c has been shown to regulate the epithelial-mesenchymal transition EMT by inhibiting ZEB1 and ZEB2 expression in breast cancer cells; This study further examined the role of miR-200c in the invasion and metastasis of breast cancer that goes beyond the regulation on ZEB1 and ZEB2 expression;Overexpression of miR-200c in SN12-PM6 and 786-0 cells was concurrent with downregulation of ZEB1 and upregulation of E-cadherin mRNA and protein; Thus our study demonstrated that miR-200c decreases the metastatic ability of renal carcinoma cells by upregulating E-cadherin through ZEB1 and that modulating the expression of miR-200c could influence Akt protein levels;MiR 200c suppresses TGF β signaling and counteracts trastuzumab resistance and metastasis by targeting ZNF217 and ZEB1 in breast cancer; MiR-200c which was the most significantly downregulated miRNA in trastuzumab-resistant cells restored trastuzumab sensitivity and suppressed invasion of breast cancer cells by concurrently targeting ZNF217 a transcriptional activator of TGF-β and ZEB1 a known mediator of TGF-β signaling; Given the reported backward inhibition of miR-200c by ZEB1 ZNF217 also exerts a feedback suppression of miR-200c via TGF-β/ZEB1 signaling; Restoration of miR-200c silencing of ZEB1 or ZNF217 or blockade of TGF-β signaling increased trastuzumab sensitivity and suppressed invasiveness of breast cancer cells;Accordingly the enforced expression of miR-200c and mir-141 resulted in a significant upregulation in E-cadherin expression contrary to the significant downregulation in ZEB1 expression in 3 cell lines UTSCC-24A UTSCC-24B and UTSCC-6A cells;Furthermore miR-200c was found to be important in modulating ZEB1 upregulation by ERG;Of this family miR-200c has garnered particular attention as a consequence of its ability to target ZEB1 and ZEB2 mediators of epithelial- mesenchymal transition;miR 200c inhibits invasion and migration in human colon cancer cells SW480/620 by targeting ZEB1; Among those dysregulated microRNAs miR-200c was speculated to inhibit metastasis by targeting ZEB1; Overexpression of miR-200c was concurrent with downregulation of ZEB1 mRNA and protein; Taken together our study demonstrated that miR-200c inhibits metastatic ability by targeting ZEB1 in colon cancer cells SW480/620 and suggested that modulation of miR-200c could serve as therapeutic tool for inhibiting metastasis in colorectal cancer;Epigenetic Silencing of miR 200c in Breast Cancer Is Associated with Aggressiveness and Is Modulated by ZEB1;Concomitant with the increase in miR-200b and miR-200c ZEB1 expression was decreased and cells appeared more epithelial in morphology and were sensitized to TAM and fulvestrant inhibition	;metastasis;;metastasis;drug resistance;;;;metastasis;;	lung cancer;breast cancer;kidney renal cell cancer;breast cancer;head and neck cancer;prostate cancer;breast cancer;colon cancer;breast cancer;breast cancer
hsa-miR-200c-3p	ZEB2	6.47012025883743	2.64500707716408e-26	-2.47282736566539	5.20852277574619e-05	miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP	-0.432652376485522	5.29696777085928e-18	24710933;26935975;21682933;25052237;18925646;24885194	miR-200c has been shown to regulate the epithelial-mesenchymal transition EMT by inhibiting ZEB1 and ZEB2 expression in breast cancer cells; This study further examined the role of miR-200c in the invasion and metastasis of breast cancer that goes beyond the regulation on ZEB1 and ZEB2 expression;MicroRNA 200c inhibits the metastasis of non small cell lung cancer cells by targeting ZEB2 an epithelial mesenchymal transition regulator;Of this family miR-200c has garnered particular attention as a consequence of its ability to target ZEB1 and ZEB2 mediators of epithelial- mesenchymal transition;miR 200c modulates ovarian cancer cell metastasis potential by targeting zinc finger E box binding homeobox 2 ZEB2 expression; Luciferase reporter assay confirmed the target of miR-200c as ZEB2; Furthermore miR-200c expression inhibited ovarian cancer cell ES-2 migration and invasion capacity by suppression of ZEB2 expression p < 0.01; Thus targeting of miR-200c or ZEB2 may serve as a potential therapeutic strategy for control of ovarian cancer;We established by quantitative RT-PCR that in CCCs in which miR-141 and miR-200c were down-regulated ZFHX1B a transcriptional repressor for CDH1/E-cadherin tended to be up-regulated; On the basis of these findings we suggest that down-regulation of miR-141 and miR-200c in CCCs might be involved in suppression of CDH1/E-cadherin transcription via up-regulation of ZFHX1B;Two gastric cancer cell lines were treated with IGF-I to induce EMT and levels of transcription factor ZEB2 and microRNA-200c miR-200c were measured; Furthermore both Akt/ERK inhibitors and knockdown of Akt/ERK gene reversed IGF-I-induced ZEB2 up-regulation and EMT through up-regulation of miR-200c suggesting the involvement of an Akt/ERK-miR-200c-ZEB2 axis in IGF-I-induced EMT	metastasis;metastasis;;metastasis;;	breast cancer;lung squamous cell cancer;breast cancer;ovarian cancer;kidney renal cell cancer;gastric cancer
hsa-miR-200c-3p	ZFHX4	6.47012025883743	2.64500707716408e-26	-3.24470875467541	0.0166841002561569	miRNATAP	-0.487540868543922	2.3495154787838e-05		NA	NA	NA
hsa-miR-200c-3p	ZFP37	6.47012025883743	2.64500707716408e-26	-1.78486478009201	0.0653728388530415	mirMAP	-0.194190245688807	0.0193405095330181		NA	NA	NA
hsa-miR-200c-3p	ZFPM2	6.47012025883743	2.64500707716408e-26	-4.98416670049111	3.64077996689347e-05	miRNAWalker2_validate;miRTarBase;miRNATAP	-0.459353569317028	8.95829339403547e-06		NA	NA	NA
hsa-miR-200c-3p	ZNF423	6.47012025883743	2.64500707716408e-26	-4.44330743732874	5.41130570683002e-06	MirTarget	-0.454565123100415	4.77817606270741e-08		NA	NA	NA
hsa-miR-200c-3p	ZNF516	6.47012025883743	2.64500707716408e-26	-2.37643235554751	0.000281117661767563	mirMAP;miRNATAP	-0.121290659459521	0.0318743283873794		NA	NA	NA
hsa-miR-200c-3p	ZNF532	6.47012025883743	2.64500707716408e-26	-0.649960825484786	0.183521921069682	MirTarget;miRNATAP	-0.152166841555222	0.000243551639900262		NA	NA	NA
hsa-miR-200c-3p	ZNF772	6.47012025883743	2.64500707716408e-26	-2.60657405066085	0.0328229507958995	mirMAP	-0.248642726310168	0.0176658106265359		NA	NA	NA