miRNA	gene	miRNA_log2FC	miRNA_pvalue	gene_log2FC	gene_pvalue	interactions	correlation_beta	correlation_pvalue	PMID	evidence	outcome	cancer
hsa-let-7b-5p	CBX2	-0.959013717270803	5.95127281258643e-11	2.25351244295968	1.73782786388514e-22	miRNATAP	-0.286085043662464	0.00030345826859684		NA	NA	NA
hsa-let-7g-5p	CBX2	-0.461294133285527	2.17210114729901e-05	2.25351244295968	1.73782786388514e-22	miRNATAP	-0.482060446058579	8.94773131930995e-06		NA	NA	NA
hsa-miR-192-3p	CBX2	-0.6401165114007	0.000266272092403814	2.25351244295968	1.73782786388514e-22	mirMAP	-0.361931200652024	5.20156394487343e-08		NA	NA	NA
hsa-miR-29a-3p	CBX2	-0.856762511178136	4.65330336378459e-12	2.25351244295968	1.73782786388514e-22	miRNATAP	-0.314779278039623	0.000783443517997259		NA	NA	NA
hsa-miR-29c-3p	CBX2	-1.4367517608807	1.61767774905781e-21	2.25351244295968	1.73782786388514e-22	miRNATAP	-0.489743689744466	2.54398320619688e-11		NA	NA	NA
hsa-miR-3614-5p	CBX2	-1.66311416965679	1.26647181860439e-15	2.25351244295968	1.73782786388514e-22	mirMAP	-0.226187432068667	4.65580499750754e-05		NA	NA	NA
hsa-miR-378a-3p	CBX2	-1.1920055906972	3.23538871733634e-10	2.25351244295968	1.73782786388514e-22	mirMAP	-0.26237825564136	1.6843642459561e-05		NA	NA	NA
hsa-miR-378c	CBX2	-1.54028191929038	2.70131554214866e-15	2.25351244295968	1.73782786388514e-22	mirMAP	-0.311434118824184	8.60187300509391e-08		NA	NA	NA
hsa-miR-193b-3p	CBX6	-0.166697207281748	0.272022543069482	-0.135925898836227	0.562356772831778	mirMAP	-0.378690931550169	4.00793341751614e-07		NA	NA	NA
hsa-miR-194-3p	CBX6	-0.772747277805343	2.9537465170191e-05	-0.135925898836227	0.562356772831778	mirMAP	-0.260902475665137	1.802373997442e-05		NA	NA	NA
hsa-miR-22-3p	CBX6	-0.628561621952407	1.33755558015523e-09	-0.135925898836227	0.562356772831778	MirTarget	-0.47007463368136	1.40321135669485e-05		NA	NA	NA
hsa-miR-224-3p	CBX6	1.40770116795301	1.31426607144612e-08	-0.135925898836227	0.562356772831778	mirMAP	-0.163448648103912	0.000351212501632372		NA	NA	NA
hsa-miR-28-5p	CBX6	-0.430964830599964	2.67367257252925e-06	-0.135925898836227	0.562356772831778	mirMAP	-0.461405199505667	0.0002012496726922		NA	NA	NA
hsa-miR-3607-3p	CBX6	-2.15518588554493	1.03390728226728e-23	-0.135925898836227	0.562356772831778	mirMAP	-0.129907113749732	0.00972196675416719		NA	NA	NA
hsa-miR-378a-5p	CBX6	-1.58667444700188	3.19640857320504e-17	-0.135925898836227	0.562356772831778	mirMAP	-0.199585950714738	0.000609204436242624		NA	NA	NA
hsa-miR-125a-3p	CECR2	-0.841683158494395	3.51202687176603e-05	-0.778592534654497	0.0128182957319807	miRanda	-0.471252668236388	2.98631635301743e-10		NA	NA	NA
hsa-miR-125a-5p	CECR2	-0.91219969372382	1.38256246489548e-07	-0.778592534654497	0.0128182957319807	miRanda	-0.521479240469172	1.09479171262422e-09		NA	NA	NA
hsa-miR-200b-3p	CECR2	-1.29335788099229	0.000268623234305059	-0.778592534654497	0.0128182957319807	TargetScan	-0.298292772668827	7.5387201060145e-13		NA	NA	NA
hsa-miR-299-5p	CECR2	-1.29140172063665	7.07032129116092e-07	-0.778592534654497	0.0128182957319807	miRNATAP	-0.181849391727233	0.00210977342409239		NA	NA	NA
hsa-miR-320b	CECR2	0.0919652022571331	0.607981643616945	-0.778592534654497	0.0128182957319807	miRanda	-0.271128276539774	0.00158084529320195		NA	NA	NA
hsa-miR-324-5p	CECR2	0.372933276649782	0.00592280066108904	-0.778592534654497	0.0128182957319807	miRanda	-0.302392751277609	0.00743773530104978		NA	NA	NA
hsa-miR-429	CECR2	-1.40262535827285	6.93982219171912e-05	-0.778592534654497	0.0128182957319807	PITA;miRanda;miRNATAP	-0.311334450832591	1.89804114701478e-13		NA	NA	NA
hsa-miR-130b-5p	CHD3	0.170599813152408	0.337611586432771	0.692052875822848	0.000238267623103004	mirMAP	-0.258586731295314	5.08976590372715e-07		NA	NA	NA
hsa-miR-23b-5p	CHD3	-1.05289229952702	7.22203199173865e-13	0.692052875822848	0.000238267623103004	MirTarget	-0.20925783037381	0.000828831754620084		NA	NA	NA
hsa-miR-28-5p	CHD3	-0.430964830599964	2.67367257252925e-06	0.692052875822848	0.000238267623103004	miRanda	-0.57524069727011	6.69577488019375e-09		NA	NA	NA
hsa-miR-1269a	EYA2	3.57543539205634	4.25369619949175e-08	-2.24669009462582	2.53906424525403e-11	MirTarget	-0.119628598836343	5.98596260760561e-06		NA	NA	NA
hsa-miR-30d-5p	EYA2	0.718283816348023	2.47422074061352e-08	-2.24669009462582	2.53906424525403e-11	miRNATAP	-0.455191698256875	0.000405979583645675		NA	NA	NA
hsa-let-7b-5p	EZH2	-0.959013717270803	5.95127281258643e-11	2.56936752791081	3.12233537592977e-46	miRNATAP	-0.273053829571765	2.98029088605658e-05	25611389	Significant inverse correlation between EZH2 and hsa-miR-26a-5p R2=0.56 P=0.0001 and hsa-let-7b-5p R2=0.19 P=0.02 expression was observed in the same samples corroborating the belief of EZH2 being a bona fide target for these two miRNAs in CRC		colorectal cancer
hsa-let-7g-5p	EZH2	-0.461294133285527	2.17210114729901e-05	2.56936752791081	3.12233537592977e-46	miRNATAP	-0.282845848560604	0.00175658306533952		NA	NA	NA
hsa-miR-101-3p	EZH2	-1.48176407980989	3.98950707385704e-31	2.56936752791081	3.12233537592977e-46	miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP	-0.759013473060081	6.28053761420465e-30	24002871;26718325;24211739;26251675;22108826;24490857;23962556;21818714;25260883;25428391;27620004;22450781;25400732;25190211;22977606;24807198;21321380;22094936;21270667	miR-101 in turn inhibits the expression of two subunits of PRC2 EZH2 and EED thus creating a double-negative feedback loop that regulates the process of hepatocarcinogenesis; In addition co-overexpression of c-Myc and EZH2 in HCC samples was closely associated with lower expression of miR-101 P < 0.0001 and poorer prognosis of HCC patients P < 0.01;Reporter gene assays revealed that ectopic expression of EZH2 inhibited the transcriptional activities of miR-101-1 promoter; Moreover our results also demonstrated that similar antitumor effects can be achieved either by ectopic miR-101 or EZH2 silencing in HCC cells; These findings show that elevated EZH2 contributes to miR-101 deregulation in HCC and highlight the coordinated role of miR-101 and EZH2 in hepatocarcinogenesis;The aim of our study was to investigate the functional role of both miR-101 and EZH2 in human hepatocellular carcinoma HCC; MiR-101 and EZH2 expressions were evaluated in tumor tissues of 99 HCC patients and 7 liver cancer cell lines by real-time PCR; Luciferase reporter assay was employed to validate whether EZH2 represents a target gene of miR-101; MiR-101 expression was significantly downregulated in most of HCC tissues and all cell lines whereas EZH2 was significantly overexpressed in most of HCC tissues and all cell lines; There was a negative correlation between expression levels of miR-101 and EZH2; Luciferase assay results confirmed EZH2 as a direct target gene of miR-101 which negatively regulates EZH2 expression in HCC; Tumor suppressor miR-101 represses HCC progression through directly targeting EZH2 oncogene and sensitizes liver cancer cells to chemotherapeutic treatment;MiR-101 is a microRNA involved in a negative feedback circuit with EZH2 in different normal and tumor tissues; To that miR-101 can behave as a tumor suppressor in several cancers by repressing EZH2 expression; We therefore evaluated whether miR-101 is de-regulated in eRMS and investigated its interplaying with EZH2 as well as its role in the in vitro tumorigenic potential of these tumor cells; Herein we report that miR-101 is down-regulated in eRMS patients and in tumor cell lines compared to their controls showing an inverse pattern of expression with EZH2; We also show that miR-101 is up-regulated in eRMS cells following both genetic and pharmacological inhibition of EZH2; In turn miR-101 forced expression reduces EZH2 levels as well as restrains the migratory potential of eRMS cells and impairs their clonogenic and anchorage-independent growth capabilities; This phenomenon is associated to reduced H3K27me3 levels at the same regulatory locus indicating that EZH2 directly targets miR-101 for repression in eRMS cells; Altogether our data show that in human eRMS miR-101 is involved in a negative feedback loop with EZH2 whose targeting has been previously shown to halt eRMS tumorigenicity;Mechanistic investigations revealed that reexpression of miR-101 was sufficient to limit the expression of EZH2 and the proinvasive cell surface adhesion molecule EpCAM;Methyl jasmonate sensitizes human bladder cancer cells to gambogic acid induced apoptosis through down regulation of EZH2 expression by miR 101; Furthermore treatment of bladder cancer cells with a combination of GA and MJ induced synergistic inhibition of the enhancer of zeste homologue 2 EZH2 expression whereas miR-101 expression was up-regulated; Conversely knockdown of miR-101 restored this decreased expression of EZH2 and suppressed the inhibitory effect of GA and MJ on the growth of bladder cancer cells; MJ sensitizes bladder cancer cells to GA-induced apoptosis by down-regulating the expression of EZH2 induced by miR-101;MiR 101 inhibits melanoma cell invasion and proliferation by targeting MITF and EZH2; Functional assays showed that miR-101 suppressed invasion and proliferation - an outcome that could be phenocopied by siRNA knockdown of MITF and EZH2;We explore the role of miR-101 and its interaction with EzH2 in epithelial ovarian carcinoma EOC; CHIP assays revealed that re-expression of miR-101 inhibited the interaction of EzH2 with p21waf1/cip1 promoter;miR 101 regulates expression of EZH2 and contributes to progression of and cisplatin resistance in epithelial ovarian cancer; miR-101 overexpression decreased the expression of EZH2 reduced proliferation and migration of ovarian cancer cells and resensitized drug-resistant cancer cells to cisplatin-induced cytotoxicity suggesting the important role miR-101 plays in ovarian cancer that may be associated with its function as a regulator targeting EZH2;The results showed that mir-101 was down-regulated and EZH2 were upregulated; Subsequently the roles of mir-101 and EZH2 in tumor growth and progression in vitro were tested; Overexpression of mir-101 mimics was able to suppress the expression of EZH2 in XWLC-05 cells; Interleukin-1β subsequently induces the downregulation of mir-101 which may result in the upregulated level of EZH2 and occurrence of lung cancer;Long non coding RNA XIST regulates gastric cancer progression by acting as a molecular sponge of miR 101 to modulate EZH2 expression;Moreover around 40% of cases showing miR-101 down-regulation displayed concomitant EZH2 over-expression at the RNA and protein levels which in turn was associated with loss/aberrant expression of E-cadherin; In conclusion we show that deletions and/or microdeletions at both miR-101 genomic loci cause mature miR-101 down-regulation subsequent EZH2 over-expression and E-cadherin dysfunction specifically in intestinal-type GC;miR 101 suppresses tumor proliferation and migration and induces apoptosis by targeting EZH2 in esophageal cancer cells; The expression level of miR-101 was inversely correlated to EZH2 protein expression in ESCC cell; These findings suggest that decreased expression of miR-101 might promote metastasis of human ESCC by inducing accumulation of EZH2 protein;In the present study we reported that ectopic overexpression of miR-101 downregulated the expression level of EZH2 and significantly inhibited migration and invasion of osteosarcoma cells; In addition knockdown of EZH2 by siRNA showed the same effect of miR-101 on migration and invasion; To conclude these results indicate that miR-101 may act as a tumor suppressor in osteosarcoma as it has a suppressive role in cell migration and invasion by targeting EZH2;Therefore we aimed to ascertain whether or not the overexpression of miR-101 inhibits invasion of lung cancer through regulation of EZH2; In this study the expression of miR-101 was down-regulated and the expression of EZH2 was up-regulated in lung cancer; Overexpression of miR-101 induced a marked reduction in EZH2 mRNA levels in several lung cancer cell lines; miR-101 may be a potent tumor suppressor by altering chromatin structure through repression of EZH2 and may be a potential therapeutic tool for patients with lung cancer;MiR 101 downregulated in retinoblastoma functions as a tumor suppressor in human retinoblastoma cells by targeting EZH2; Finally we found that miR-101 directly inhibited EZH2 expression by targeting its 3'-UTR and EZH2 was upregulated and inversely correlated with miR-101 expression in the retinoblastoma tissues; Thus for the first time we provide convincing evidence that downregulation of miR-101 is associated with tumor aggressiveness in retinoblastoma and inhibits cell growth and proliferation of retinoblastoma cells by targeting EZH2;miR 101 is down regulated in glioblastoma resulting in EZH2 induced proliferation migration and angiogenesis; Here we determined that miR-101 is down-regulated in GBM resulting in overexpression of the miR-101 target PcG protein EZH2 a histone methyltransferase affecting gene expression profiles in an epigenetic manner; Our results indicate that EZH2 has a versatile function in GBM progression and that its overexpression is at least partly due to decreased miR-101 expression;Main objective of the present study is to investigate miR-26a and miR-101 levels which both target EZH2 for their association with molecular pathways and with efficacy of tamoxifen as first-line monotherapy for metastatic breast cancer;In this study we investigate whether miRNA miR-101 regulates EZH2 expression in NSCLC; We evaluated the expression of miR-101 and EZH2 in 20 matched NSCLC and adjacent nontumor lung tissues by reverse-transcriptase polymerase chain reaction and immunohistochemistry respectively; Luciferase reporter assay was used to determine whether miR-101 directly targets EZH2; To assess the effect of miR-101 on NSCLC biological behavior cell proliferation invasion and response to chemotherapy were analyzed using NSCLC cells transfected with miR-101 mimics or transfected with specific small interfering RNA to deplete EZH2 small interfering RNA-EZH2; Reduced expression of miR-101 was associated with overexpression of EZH2 in NSCLC tumor tissues; Transfection of miR-101 mimics significantly suppressed the activity of the luciferase reporter containing wild type but not mutant EZH2 3'-UTR and decreased EZH2 expression in NSCLC cell lines; Therapeutic strategies to rescue miR-101 expression or silence EZH2 may be beneficial to patients with NSCLC in the future	tumorigenesis;worse prognosis;tumorigenesis;progression;;;;;;progression;drug resistance;progression;progression;;metastasis;cell migration;;;progression;;drug resistance	liver cancer;liver cancer;liver cancer;sarcoma;pancreatic cancer;bladder cancer;melanoma;ovarian cancer;ovarian cancer;lung cancer;gastric cancer;gastric cancer;esophageal cancer;sarcoma;lung cancer;retinoblastoma;glioblastoma;breast cancer;lung squamous cell cancer
hsa-miR-139-5p	EZH2	-2.11299531796557	8.16407076415038e-28	2.56936752791081	3.12233537592977e-46	miRanda	-0.594332946878018	6.29963320424694e-44		NA	NA	NA
hsa-miR-144-3p	EZH2	-2.97536914478815	6.00546047309683e-28	2.56936752791081	3.12233537592977e-46	miRNATAP	-0.264373172345385	5.91588465496351e-16	23815091	miR 144 downregulation increases bladder cancer cell proliferation by targeting EZH2 and regulating Wnt signaling		bladder cancer
hsa-miR-199a-5p	EZH2	-1.98848462405923	2.0421622713753e-11	2.56936752791081	3.12233537592977e-46	miRNAWalker2_validate	-0.20459098581409	1.02535117313981e-10		NA	NA	NA
hsa-miR-26a-5p	EZH2	-0.963792031426845	1.83360999387345e-22	2.56936752791081	3.12233537592977e-46	miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP	-0.548403243844921	4.94632285100434e-09	26733151;25494962;20952513;23750239;25611389;24452597;21901171;27517917;22086681;27562865;22930729;22094936	Through down-regulation of EZH2 expression and up-regulation of E-cadherin expression miR-26a inhibited the EMT process in vitro and in vivo; Luciferase reporter assay showed that miR-26a directly interacted with EZH2 messenger RNA mRNA; Furthermore the expression of miR-26a was positively correlated with E-cadherin expression and inversely correlated with EZH2 expression in human HCC tissue; miR-26a inhibited the EMT process in HCC by down-regulating EZH2 expression;miR 26a promoted by interferon alpha inhibits hepatocellular carcinoma proliferation and migration by blocking EZH2; Here we report that the IFN-α-induced microRNA-26a miR-26a can inhibit HCC proliferation and invasion by suppressing enhancer of zeste homologue 2 EZH2 expression in tumor cells; It was shown that there was increased miR-26a accompanied with downregulated EZH2 expression in the HCC specimens and EZH2 mRNA levels were inversely correlated with miR-26a expression; In addition the miR-26a mimic transfection decreased the EZH2 expression level significantly in the transfected HepG2 cells and inhibited HepG2 cell proliferation and invasion effectively; Our results indicate that miR-26a exerts growth inhibition in HCC and that its inhibitory effect is mediated briefly by blocking EZH2 expression;Pathologically decreased miR 26a antagonizes apoptosis and facilitates carcinogenesis by targeting MTDH and EZH2 in breast cancer; Subsequently MTDH and EZH2 are identified as two direct targets of miR-26a and they are significantly upregulated in breast cancer; MCF7 xenografts with exogenous miR-26a show that a decrease in expression of both MTDH and EZH2 is accompanied by an increase in apoptosis; Our findings suggest that miR-26a functionally antagonizes human breast carcinogenesis by targeting MTDH and EZH2;MiR-26a has been reported as a tumor suppressor microRNA in breast cancer which is attributed mainly to targeting of MTDH and EZH2 however the expression profile and therapeutic potential of miR-26a is still unclear;Significant inverse correlation between EZH2 and hsa-miR-26a-5p R2=0.56 P=0.0001 and hsa-let-7b-5p R2=0.19 P=0.02 expression was observed in the same samples corroborating the belief of EZH2 being a bona fide target for these two miRNAs in CRC;Moreover EZH2 was upregulated and inversely correlated with miR-26a expression in the osteosarcoma tissues; Thus for the first time we provide convincing evidence that downregulation of miR-26a is associated with tumor aggressiveness and tumor metastasis and miR-26a inhibits cell migration and invasion by targeting the EZH2 gene in osteosarcoma;Previously EZH2 was shown to be regulated by miR-26a at the translational levels in lymphomas;miR-26a inhibition partly prevents the metformin viability effect and the PTEN and EZH2 expression reduction;We also found that reexpression of miR-26a by transfection led to decreased expression of EZH2 and EpCAM in pancreatic cancer cells;In the present study the influence of miR-26a and miR-138 on EZH2 and cellular function including the impact on the cell cycle regulating network was evaluated in PCa cells; The present findings suggest an anti-proliferative role for miR-26a and miR-138 in PCa by blocking the G1/S-phase transition independent of EZH2 but via a concerted inhibition of crucial cell cycle regulators;We propose the hypermethylation of miR-26a as an alternative pathway of ERG rearrangement-independent EZH2 activation;High miR 26a and low CDC2 levels associate with decreased EZH2 expression and with favorable outcome on tamoxifen in metastatic breast cancer; Main objective of the present study is to investigate miR-26a and miR-101 levels which both target EZH2 for their association with molecular pathways and with efficacy of tamoxifen as first-line monotherapy for metastatic breast cancer; Cell cycle regulation and CCNE1 and CDC2 were the only significant overlapping pathway and genes differentially expressed between tumors with high and low levels of miR-26a and EZH2 respectively; Cell cycle regulation is the only overlapping pathway linked to miR-26a and EZH2 levels; Low mRNA levels of EZH2 CCNE1 and CDC2 and high levels of miR-26a are associated with favorable outcome on tamoxifen	;;tumorigenesis;;;metastasis;cell migration;;;;;;	liver cancer;liver cancer;breast cancer;breast cancer;colorectal cancer;sarcoma;acute myeloid leukemia;breast cancer;pancreatic cancer;prostate cancer;prostate cancer;breast cancer
hsa-miR-26b-5p	EZH2	-1.10804856399744	4.14176110314282e-22	2.56936752791081	3.12233537592977e-46	MirTarget;miRNATAP	-0.599322414887036	5.13305977252849e-14		NA	NA	NA
hsa-miR-450b-5p	EZH2	-1.34333360369432	2.68386079790462e-17	2.56936752791081	3.12233537592977e-46	MirTarget;PITA;miRNATAP	-0.366065290478143	3.99359124574066e-10		NA	NA	NA
hsa-miR-193a-5p	HDAC9	-0.472805720224262	1.24962968905481e-05	-1.15719039438144	2.74522046804511e-08	PITA	-0.360623050076495	0.000143305471247506		NA	NA	NA
hsa-miR-30d-5p	HDAC9	0.718283816348023	2.47422074061352e-08	-1.15719039438144	2.74522046804511e-08	miRNATAP	-0.360735038979126	4.33765838944761e-06		NA	NA	NA
hsa-miR-361-5p	HDAC9	0.233202959858696	0.00961572812255327	-1.15719039438144	2.74522046804511e-08	PITA;miRanda;miRNATAP	-0.381772220084933	0.000966172533989335		NA	NA	NA
hsa-miR-455-5p	HDAC9	-0.270546034117157	0.0581320703577731	-1.15719039438144	2.74522046804511e-08	miRanda	-0.416152366236071	5.47966947735502e-09		NA	NA	NA
hsa-miR-618	HDAC9	0.13539895350352	0.517145913114103	-1.15719039438144	2.74522046804511e-08	PITA	-0.267817599690851	1.19269401496917e-07		NA	NA	NA
hsa-let-7b-3p	HELLS	-1.21979213547786	5.84575581584603e-17	2.62327787224869	1.35869467447747e-28	mirMAP	-0.690919274438889	1.3128464972458e-18		NA	NA	NA
hsa-let-7b-5p	HELLS	-0.959013717270803	5.95127281258643e-11	2.62327787224869	1.35869467447747e-28	miRNAWalker2_validate	-0.354349414040168	1.59334135234248e-05		NA	NA	NA
hsa-let-7f-1-3p	HELLS	-0.704017923073338	7.84883628944999e-07	2.62327787224869	1.35869467447747e-28	mirMAP	-0.369335423645757	1.97824745871454e-05		NA	NA	NA
hsa-miR-148a-5p	HELLS	-0.767626696027761	1.08359477494797e-06	2.62327787224869	1.35869467447747e-28	mirMAP	-0.205649452725597	0.00818152736505431		NA	NA	NA
hsa-miR-193b-3p	HELLS	-0.166697207281748	0.272022543069482	2.62327787224869	1.35869467447747e-28	miRNAWalker2_validate	-0.223337369031478	0.00631450884049105		NA	NA	NA
hsa-miR-195-3p	HELLS	-1.09375690196245	4.70092324819807e-09	2.62327787224869	1.35869467447747e-28	mirMAP	-0.251852359805342	0.000124063785991174		NA	NA	NA
hsa-miR-199a-5p	HELLS	-1.98848462405923	2.0421622713753e-11	2.62327787224869	1.35869467447747e-28	miRanda	-0.209683835276353	1.71950235515908e-07		NA	NA	NA
hsa-miR-24-1-5p	HELLS	-1.3235267368749	6.56628864624956e-23	2.62327787224869	1.35869467447747e-28	MirTarget	-0.773453155062653	2.0383256921905e-20		NA	NA	NA
hsa-miR-29b-1-5p	HELLS	-0.538946836809295	0.00102913307251186	2.62327787224869	1.35869467447747e-28	mirMAP	-0.338011601929218	5.88447180355317e-06		NA	NA	NA
hsa-miR-30a-3p	HELLS	-1.52720594401486	1.3830066075708e-17	2.62327787224869	1.35869467447747e-28	mirMAP	-0.535812523329536	5.51454504830925e-17		NA	NA	NA
hsa-miR-30e-3p	HELLS	-1.20845647373031	3.10263633528203e-25	2.62327787224869	1.35869467447747e-28	mirMAP	-0.528305335730091	1.0239577815381e-07		NA	NA	NA
hsa-miR-3607-3p	HELLS	-2.15518588554493	1.03390728226728e-23	2.62327787224869	1.35869467447747e-28	mirMAP	-0.346324840916352	7.90375201669512e-11		NA	NA	NA
hsa-miR-374b-5p	HELLS	-0.307538028546424	0.0030079617545972	2.62327787224869	1.35869467447747e-28	MirTarget;mirMAP	-0.324310282778161	0.00689091439281158		NA	NA	NA
hsa-miR-450b-5p	HELLS	-1.34333360369432	2.68386079790462e-17	2.62327787224869	1.35869467447747e-28	mirMAP	-0.32247917745721	1.4734575572521e-05		NA	NA	NA
hsa-miR-107	IKZF1	0.241662461253461	0.0170788899505389	-0.973272492309265	4.90450525854266e-07	miRanda	-0.331193940065874	0.000479946204892916		NA	NA	NA
hsa-miR-219a-1-3p	IKZF1	-0.065863458123071	0.645858701126434	-0.973272492309265	4.90450525854266e-07	MirTarget	-0.300930282694969	6.19643733561787e-06		NA	NA	NA
hsa-miR-32-3p	IKZF1	0.219109440121582	0.207217051619543	-0.973272492309265	4.90450525854266e-07	mirMAP	-0.153415467275228	0.00705643498359204		NA	NA	NA
hsa-miR-32-5p	IKZF1	0.0806126674664016	0.548984992497432	-0.973272492309265	4.90450525854266e-07	miRNATAP	-0.231442454384688	0.00117562597650491		NA	NA	NA
hsa-miR-33a-3p	IKZF1	-0.683025859637737	1.01106097756419e-05	-0.973272492309265	4.90450525854266e-07	mirMAP	-0.167237120791373	0.00644854897113849		NA	NA	NA
hsa-miR-361-5p	IKZF1	0.233202959858696	0.00961572812255327	-0.973272492309265	4.90450525854266e-07	miRanda	-0.446630084000632	2.83956400030366e-05		NA	NA	NA
hsa-miR-616-5p	IKZF1	0.150569904638223	0.402836556304524	-0.973272492309265	4.90450525854266e-07	mirMAP	-0.217783478964782	4.05477765528372e-05		NA	NA	NA
hsa-miR-93-3p	IKZF1	0.402821129107592	0.00131324842735588	-0.973272492309265	4.90450525854266e-07	mirMAP	-0.220776206987876	0.00379146618148337		NA	NA	NA
hsa-miR-106a-5p	KAT2B	-0.464229535269236	0.009724944358047	-0.938558773689222	1.89276182546283e-10	MirTarget	-0.177974942037781	1.1260418377257e-05		NA	NA	NA
hsa-miR-106b-5p	KAT2B	0.648901865047099	8.24870862047885e-09	-0.938558773689222	1.89276182546283e-10	miRNAWalker2_validate;miRTarBase;MirTarget	-0.516609867095764	9.70587347026615e-17		NA	NA	NA
hsa-miR-125a-3p	KAT2B	-0.841683158494395	3.51202687176603e-05	-0.938558773689222	1.89276182546283e-10	miRanda	-0.149961442868622	3.79098733559111e-05		NA	NA	NA
hsa-miR-17-5p	KAT2B	0.698861147045461	2.43854106455398e-05	-0.938558773689222	1.89276182546283e-10	MirTarget;TargetScan	-0.397123391532735	2.6874226483349e-21	23095762	miR 17 5p targets the p300/CBP associated factor and modulates androgen receptor transcriptional activity in cultured prostate cancer cells; Targeting of PCAF by miR-17-5p was evaluated using the luciferase reporter assay; Expression of PCAF in PCa cells was associated with the downregulation of miR-17-5p; Targeting of the 3'-untranslated region of PCAF mRNA by miR-17-5p caused translational suppression and RNA degradation and consequently modulation of AR transcriptional activity in PCa cells; PCAF is upregulated in cultured PCa cells and upregulation of PCAF is associated with the downregulation of miR-17-5p; Targeting of PCAF by miR-17-5p modulates AR transcriptional activity and cell growth in cultured PCa cells		prostate cancer
hsa-miR-181a-5p	KAT2B	0.250113435902954	0.0551933249319293	-0.938558773689222	1.89276182546283e-10	miRNAWalker2_validate;miRTarBase;MirTarget	-0.426890206635934	6.26669869314588e-15		NA	NA	NA
hsa-miR-181b-5p	KAT2B	0.488256489401108	0.00105321129419701	-0.938558773689222	1.89276182546283e-10	miRNAWalker2_validate;miRTarBase;MirTarget	-0.457990357788594	9.28981291080347e-23		NA	NA	NA
hsa-miR-181c-5p	KAT2B	-0.00639394152050299	0.969127212255928	-0.938558773689222	1.89276182546283e-10	MirTarget	-0.266357788878104	1.18828300159497e-09		NA	NA	NA
hsa-miR-181d-5p	KAT2B	0.161600964883517	0.363806828762999	-0.938558773689222	1.89276182546283e-10	MirTarget	-0.281403375774208	3.01108563113213e-12		NA	NA	NA
hsa-miR-19a-3p	KAT2B	1.01712596153672	2.57753201450625e-07	-0.938558773689222	1.89276182546283e-10	miRNAWalker2_validate	-0.258008787485568	4.91547864954381e-13		NA	NA	NA
hsa-miR-19b-3p	KAT2B	0.601279551368824	0.00016685097085251	-0.938558773689222	1.89276182546283e-10	miRNAWalker2_validate	-0.300580910813304	1.79295987685863e-11		NA	NA	NA
hsa-miR-20a-3p	KAT2B	-0.318177901603857	0.0467885456739855	-0.938558773689222	1.89276182546283e-10	MirTarget	-0.22387415848094	8.7626611878482e-07		NA	NA	NA
hsa-miR-20a-5p	KAT2B	0.854326758727003	5.04256669663285e-07	-0.938558773689222	1.89276182546283e-10	MirTarget	-0.323298461721723	5.05244582669315e-15		NA	NA	NA
hsa-miR-20b-5p	KAT2B	0.457668023910379	0.0285865211936156	-0.938558773689222	1.89276182546283e-10	MirTarget	-0.113158413426819	0.00122118573242313		NA	NA	NA
hsa-miR-25-3p	KAT2B	0.633062563556379	3.68686354834328e-10	-0.938558773689222	1.89276182546283e-10	miRNAWalker2_validate;miRTarBase;MirTarget	-0.26315834694088	0.000234459458633812		NA	NA	NA
hsa-miR-330-3p	KAT2B	-0.332364259424489	0.0316051913061459	-0.938558773689222	1.89276182546283e-10	MirTarget	-0.273076621148565	1.18029885690117e-08		NA	NA	NA
hsa-miR-338-5p	KAT2B	-0.221898432884726	0.252390988727086	-0.938558773689222	1.89276182546283e-10	MirTarget;miRNATAP	-0.150468534557013	7.23998844367366e-05		NA	NA	NA
hsa-miR-342-3p	KAT2B	-0.319677314984262	0.0449813878317147	-0.938558773689222	1.89276182546283e-10	miRanda	-0.182145473520516	7.12764210940437e-05		NA	NA	NA
hsa-miR-363-3p	KAT2B	-0.173737427255147	0.375186188765181	-0.938558773689222	1.89276182546283e-10	MirTarget	-0.10241917641335	0.00632876905612432		NA	NA	NA
hsa-miR-429	KAT2B	-1.40262535827285	6.93982219171912e-05	-0.938558773689222	1.89276182546283e-10	miRanda	-0.126975505385946	5.96195481912027e-10		NA	NA	NA
hsa-miR-590-5p	KAT2B	-0.103355559980404	0.310027295317092	-0.938558773689222	1.89276182546283e-10	miRanda	-0.257419834100684	0.000396387524632938		NA	NA	NA
hsa-miR-92a-3p	KAT2B	0.212391012518195	0.134292268089997	-0.938558773689222	1.89276182546283e-10	miRNAWalker2_validate;MirTarget	-0.347457157937997	7.47334920381898e-12		NA	NA	NA
hsa-miR-92b-3p	KAT2B	0.220374930803974	0.296187538889092	-0.938558773689222	1.89276182546283e-10	MirTarget	-0.225978769790196	3.27927891292608e-11		NA	NA	NA
hsa-miR-93-5p	KAT2B	1.39518349670953	2.84167728726712e-25	-0.938558773689222	1.89276182546283e-10	miRNAWalker2_validate;miRTarBase;MirTarget	-0.378141581227996	4.36815875562486e-14		NA	NA	NA
hsa-miR-26b-5p	KDM5D	-1.10804856399744	4.14176110314282e-22	0.896680298788518	0.209088951644024	miRNAWalker2_validate	-0.860243420675664	0.00296798574174009		NA	NA	NA
hsa-miR-335-5p	KDM5D	-1.61347836513558	1.62757083289711e-19	0.896680298788518	0.209088951644024	miRNAWalker2_validate	-0.506301445640794	0.00655628704462047		NA	NA	NA
hsa-miR-101-3p	LMNB1	-1.48176407980989	3.98950707385704e-31	0.979593605630488	1.58971612415829e-08	miRNAWalker2_validate;MirTarget;miRNATAP	-0.363386426286137	3.63670009776497e-09		NA	NA	NA
hsa-miR-199a-5p	LMNB1	-1.98848462405923	2.0421622713753e-11	0.979593605630488	1.58971612415829e-08	miRanda	-0.107624820919315	0.000126966407123032		NA	NA	NA
hsa-miR-26b-5p	LMNB1	-1.10804856399744	4.14176110314282e-22	0.979593605630488	1.58971612415829e-08	miRNAWalker2_validate	-0.20958196347398	0.00338031545540921		NA	NA	NA
hsa-miR-3065-3p	LMNB1	-1.04244468016704	4.60743424372577e-05	0.979593605630488	1.58971612415829e-08	MirTarget;miRNATAP	-0.115191088636423	0.000517495985829552		NA	NA	NA
hsa-miR-30a-3p	LMNB1	-1.52720594401486	1.3830066075708e-17	0.979593605630488	1.58971612415829e-08	miRNATAP	-0.286448827020433	2.43956742800782e-10		NA	NA	NA
hsa-miR-122-5p	LMNB2	-1.23907441373955	4.42181244888642e-06	1.15533579106848	2.8635849155846e-19	miRNAWalker2_validate	-0.28450973586539	1.00164307127218e-38		NA	NA	NA
hsa-miR-125b-5p	LMNB2	-1.35767721102906	1.16564617395164e-18	1.15533579106848	2.8635849155846e-19	mirMAP	-0.353152545489547	1.76356825043745e-19		NA	NA	NA
hsa-miR-145-3p	LMNB2	-1.14463889739974	1.26292637743255e-10	1.15533579106848	2.8635849155846e-19	mirMAP	-0.100103909993399	0.00550334546101417		NA	NA	NA
hsa-miR-192-5p	LMNB2	-0.50188499512787	0.00344713341196035	1.15533579106848	2.8635849155846e-19	miRNAWalker2_validate	-0.286225570514038	1.00336825060293e-14		NA	NA	NA
hsa-miR-193b-3p	LMNB2	-0.166697207281748	0.272022543069482	1.15533579106848	2.8635849155846e-19	miRNAWalker2_validate	-0.272224524447235	1.54599367265685e-10		NA	NA	NA
hsa-miR-195-5p	LMNB2	-1.85907534356434	1.47434041676402e-22	1.15533579106848	2.8635849155846e-19	mirMAP	-0.179824348225847	2.39306441872655e-08		NA	NA	NA
hsa-miR-215-5p	LMNB2	-0.981544773246509	3.14452272477156e-05	1.15533579106848	2.8635849155846e-19	miRNAWalker2_validate	-0.138983534889371	3.4167299463477e-07		NA	NA	NA
hsa-miR-30a-5p	LMNB2	-0.626257932887855	0.000108198196973765	1.15533579106848	2.8635849155846e-19	miRNAWalker2_validate	-0.134684143108412	0.000819309087979932		NA	NA	NA
hsa-miR-424-5p	LMNB2	-2.62653257498508	2.38997974737991e-50	1.15533579106848	2.8635849155846e-19	mirMAP	-0.143491396946239	1.12700005429612e-05		NA	NA	NA
hsa-miR-497-5p	LMNB2	-1.41371173021948	7.09278946477743e-17	1.15533579106848	2.8635849155846e-19	mirMAP	-0.17688207381919	1.68432076444336e-06		NA	NA	NA
hsa-miR-664a-5p	LMNB2	-0.0738022124558593	0.597681758599428	1.15533579106848	2.8635849155846e-19	mirMAP	-0.205557757785884	1.13528004107158e-05		NA	NA	NA
hsa-miR-330-3p	NCOA2	-0.332364259424489	0.0316051913061459	-0.550835934304429	0.0635255832217545	PITA	-0.305642951125403	0.00141472841432936		NA	NA	NA
hsa-miR-339-5p	NCOA2	0.280589919878422	0.0355660282647215	-0.550835934304429	0.0635255832217545	miRanda	-0.491944194389017	5.23360872755423e-06		NA	NA	NA
hsa-miR-186-5p	PHC1	-0.060103391373687	0.535288717081205	-0.347877085596097	0.0226840114207948	mirMAP	-0.203403576888584	0.00896996045558213		NA	NA	NA
hsa-miR-22-3p	PHC1	-0.628561621952407	1.33755558015523e-09	-0.347877085596097	0.0226840114207948	MirTarget	-0.186166862992157	0.00880587809171317		NA	NA	NA
hsa-miR-192-5p	PHF19	-0.50188499512787	0.00344713341196035	1.31515412555065	1.20077313718174e-18	miRNAWalker2_validate	-0.222092476769903	3.69245912036561e-07		NA	NA	NA
hsa-miR-193b-3p	PHF19	-0.166697207281748	0.272022543069482	1.31515412555065	1.20077313718174e-18	miRNAWalker2_validate	-0.183341823406945	0.000248728401225803		NA	NA	NA
hsa-miR-195-5p	PHF19	-1.85907534356434	1.47434041676402e-22	1.31515412555065	1.20077313718174e-18	miRNATAP	-0.137522966731781	0.000264227674916456	25955388	MicroRNA 195 5p acts as an anti oncogene by targeting PHF19 in hepatocellular carcinoma; In addition it has been shown that miR-195 plays an important role in the molecular etiology of HCC; however the effect and possible mechanism of PHF19 on HCC is unclear and the association between PHF19 and miR-195 has seldom been addressed; Our results showed that PHF19 is a potential target of hsa-miR-195-5p based on a bioinformatic analysis and results of a luciferase reporter assay; PHF19 was downregulated after transfection with hsa-miR-195-5p mimics; In contrast overexpression of hsa-miR-195-5p in hepatoma cells reduced PHF19 expression leading to suppression of hepatoma cell invasion migration and proliferation in vitro; In addition PHF19 markedly promoted the growth of xenograft tumors while hsa-miR-195-5p markedly suppressed the growth of xenograft tumors in nude mice; These results provide evidence that PHF19 promotes HCC and is regulated by the tumor-suppressor miR-195-5p		liver cancer
hsa-miR-23b-3p	PHF19	-0.530561587109023	5.43807206823652e-07	1.31515412555065	1.20077313718174e-18	miRNATAP	-0.279834405332628	8.20758529267305e-05		NA	NA	NA
hsa-miR-3614-5p	PHF19	-1.66311416965679	1.26647181860439e-15	1.31515412555065	1.20077313718174e-18	mirMAP	-0.161253466913148	5.22455173171506e-06		NA	NA	NA
hsa-miR-424-5p	PHF19	-2.62653257498508	2.38997974737991e-50	1.31515412555065	1.20077313718174e-18	miRNATAP	-0.158071873113296	2.98972794635409e-05		NA	NA	NA
hsa-miR-664a-5p	PHF19	-0.0738022124558593	0.597681758599428	1.31515412555065	1.20077313718174e-18	mirMAP	-0.362983121702003	1.01575620004674e-11		NA	NA	NA
hsa-miR-125b-2-3p	PRDM16	-1.6609436107315	5.71534047969855e-18	-0.0350863855841362	0.920519496633606	MirTarget	-0.426855668679962	4.49946190150483e-07		NA	NA	NA
hsa-miR-1269a	PRDM16	3.57543539205634	4.25369619949175e-08	-0.0350863855841362	0.920519496633606	mirMAP	-0.144950399679336	5.89229245858342e-08		NA	NA	NA
hsa-miR-130b-3p	PRDM16	0.687190305027546	0.000109068658562255	-0.0350863855841362	0.920519496633606	mirMAP	-0.351114804905736	0.000234946052560688		NA	NA	NA
hsa-miR-144-3p	PRDM16	-2.97536914478815	6.00546047309683e-28	-0.0350863855841362	0.920519496633606	MirTarget;miRNATAP	-0.223007876756586	0.00014051523970993		NA	NA	NA
hsa-miR-186-5p	PRDM16	-0.060103391373687	0.535288717081205	-0.0350863855841362	0.920519496633606	mirMAP	-0.629854526778593	0.00041350209737255		NA	NA	NA
hsa-miR-193b-3p	PRDM16	-0.166697207281748	0.272022543069482	-0.0350863855841362	0.920519496633606	mirMAP	-0.67654389687134	1.19255390983922e-09		NA	NA	NA
hsa-miR-219a-5p	PRDM16	0.17600389823009	0.322694100196276	-0.0350863855841362	0.920519496633606	MirTarget	-0.31597101417053	0.0011889566348878		NA	NA	NA
hsa-miR-30c-1-3p	PRDM16	-1.39373825444537	6.39912952911454e-17	-0.0350863855841362	0.920519496633606	mirMAP	-0.469920901015652	2.2499209237876e-06		NA	NA	NA
hsa-miR-30e-3p	PRDM16	-1.20845647373031	3.10263633528203e-25	-0.0350863855841362	0.920519496633606	mirMAP	-0.414604361760528	0.00286180065556029		NA	NA	NA
hsa-miR-378a-3p	PRDM16	-1.1920055906972	3.23538871733634e-10	-0.0350863855841362	0.920519496633606	mirMAP	-0.4572421497343	1.6568520885056e-07		NA	NA	NA
hsa-miR-378c	PRDM16	-1.54028191929038	2.70131554214866e-15	-0.0350863855841362	0.920519496633606	mirMAP	-0.394015306715744	2.8081462723741e-06		NA	NA	NA
hsa-miR-548b-3p	PRDM16	-0.0203576084717134	0.930819503166956	-0.0350863855841362	0.920519496633606	mirMAP	-0.507862135186482	2.09274040363586e-12		NA	NA	NA
hsa-miR-550a-3p	PRDM16	0.0421988124005088	0.798971000685886	-0.0350863855841362	0.920519496633606	miRNATAP	-0.332187481614097	0.00163089187808651		NA	NA	NA
hsa-miR-618	PRDM16	0.13539895350352	0.517145913114103	-0.0350863855841362	0.920519496633606	mirMAP	-0.344999290410005	4.4286131347101e-05		NA	NA	NA
hsa-miR-146b-3p	RAD54L	-1.20799545896423	2.19859530890688e-09	3.38214047769732	1.90557614667207e-35	miRNATAP	-0.199233570603687	0.00462478757971585		NA	NA	NA
hsa-miR-26b-5p	RAD54L	-1.10804856399744	4.14176110314282e-22	3.38214047769732	1.90557614667207e-35	miRNAWalker2_validate	-0.806133227721961	7.99897495612615e-12		NA	NA	NA
hsa-miR-126-5p	TET1	-0.428561469405594	6.6035585844222e-05	1.01586909495566	6.35204436834337e-06	mirMAP	-0.409903809524932	6.64572268247619e-05		NA	NA	NA
hsa-miR-29a-3p	TET1	-0.856762511178136	4.65330336378459e-12	1.01586909495566	6.35204436834337e-06	miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP	-0.97336422149308	2.28201671501346e-33	25367851;25616722;27555295	Negative feedback of miR 29 family TET1 involves in hepatocellular cancer; MiR-29b was proved to inhibit metastasis through the targeting of TET1 indicating that downregulation of miR-29 may involve in HCC carcinogenesis and progression through potentiation of TET1 expression;Erratum to: Negative feedback of miR 29 family TET1 involves in hepatocellular cancer; miR-29b was proved to inhibit metastasis through the targeting of TET1 indicating that downregulation of miR-29 may involve in HCC carcinogenesis and progression through potentiation of TET1 expression;Furthermore data from bioinformatic analysis validated by dual-luciferase reporter gene assay showed that ten eleven translocation 1 TET1 was a direct target of miR-29a and over-expression of TET1 inhibited cell proliferation and migration which could be induced by the up-regulation of miR-29a; MiR-29a targets TET1 down regulates its expression and thus promotes EMT in breast cancer; Altogether we demonstrate that miR-29a acts as a tumor activator by targeting TET1 and induces cell proliferation and EMT in breast cancer	metastasis;progression;tumorigenesis;metastasis;progression;tumorigenesis;	liver cancer;liver cancer;breast cancer
hsa-miR-29b-3p	TET1	-0.348885528720517	0.0121441341291285	1.01586909495566	6.35204436834337e-06	miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP	-0.713669930887222	6.96093035112275e-21	25367851;25616722	Negative feedback of miR 29 family TET1 involves in hepatocellular cancer; MiR-29b was proved to inhibit metastasis through the targeting of TET1 indicating that downregulation of miR-29 may involve in HCC carcinogenesis and progression through potentiation of TET1 expression;Erratum to: Negative feedback of miR 29 family TET1 involves in hepatocellular cancer; miR-29b was proved to inhibit metastasis through the targeting of TET1 indicating that downregulation of miR-29 may involve in HCC carcinogenesis and progression through potentiation of TET1 expression	metastasis;progression;tumorigenesis;metastasis;progression;tumorigenesis	liver cancer;liver cancer
hsa-miR-29c-3p	TET1	-1.4367517608807	1.61767774905781e-21	1.01586909495566	6.35204436834337e-06	MirTarget;miRNATAP	-0.761225192065957	8.4649970950427e-32		NA	NA	NA
hsa-miR-30a-3p	TET1	-1.52720594401486	1.3830066075708e-17	1.01586909495566	6.35204436834337e-06	MirTarget	-0.242857168044121	4.068846187721e-05		NA	NA	NA
hsa-miR-30d-3p	TET1	-0.120562286038759	0.329549534782125	1.01586909495566	6.35204436834337e-06	MirTarget	-0.30860777121049	0.000608758850260206		NA	NA	NA
hsa-let-7b-5p	UHRF1	-0.959013717270803	5.95127281258643e-11	3.49841769196073	9.81871544089538e-40	miRNAWalker2_validate	-0.288344181665265	0.00248395110355204		NA	NA	NA
hsa-miR-10a-5p	UHRF1	-1.47723516092033	7.27299669108673e-16	3.49841769196073	9.81871544089538e-40	miRNAWalker2_validate	-0.404122106443226	5.1195494547677e-08		NA	NA	NA
hsa-miR-139-5p	UHRF1	-2.11299531796557	8.16407076415038e-28	3.49841769196073	9.81871544089538e-40	miRanda	-0.865484888147862	2.21138740927036e-44		NA	NA	NA
hsa-miR-378a-3p	UHRF1	-1.1920055906972	3.23538871733634e-10	3.49841769196073	9.81871544089538e-40	MirTarget	-0.377744458048642	2.15468605140824e-07		NA	NA	NA
hsa-miR-378c	UHRF1	-1.54028191929038	2.70131554214866e-15	3.49841769196073	9.81871544089538e-40	MirTarget	-0.490612986983542	1.1068205953208e-12		NA	NA	NA
hsa-miR-320b	UTY	0.0919652022571331	0.607981643616945	0.511131276573129	0.430667591853068	PITA;miRanda	-0.466437226697922	0.0086718758512825		NA	NA	NA