miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-107 ABI3BP 0.658676029898313 5.11480446318819e-07 -3.27162305036256 4.8883208620152e-18 miRanda -0.391197091973299 0.00474875571235508 NA NA NA hsa-miR-320b ABI3BP 0.226640952564488 0.378818692487242 -3.27162305036256 4.8883208620152e-18 miRanda -0.257579873500836 0.000243381106909666 NA NA NA hsa-miR-369-3p ABI3BP 0.726328379387542 0.069753480597123 -3.27162305036256 4.8883208620152e-18 miRNATAP -0.142693382897521 0.00386081281171109 NA NA NA hsa-miR-421 ABI3BP 0.170525317701774 0.535277026680289 -3.27162305036256 4.8883208620152e-18 miRanda -0.315623957267284 9.19204459818664e-06 NA NA NA hsa-miR-576-5p ABI3BP 1.02693643167056 1.14846964470173e-06 -3.27162305036256 4.8883208620152e-18 PITA -0.342911890942568 5.13510683137038e-05 NA NA NA hsa-miR-590-3p ABI3BP 0.83851360565783 0.00129224433453587 -3.27162305036256 4.8883208620152e-18 miRanda -0.324688793048088 8.73434091967009e-05 NA NA NA hsa-miR-590-5p ABI3BP 2.07441240363458 4.95240551694843e-14 -3.27162305036256 4.8883208620152e-18 miRanda -0.583515248939494 4.58177206434392e-14 NA NA NA hsa-miR-92a-3p ABI3BP -0.136362762339122 0.493412263619364 -3.27162305036256 4.8883208620152e-18 miRNATAP -0.328730567049031 0.000311314457565074 NA NA NA hsa-miR-92b-3p ABI3BP 0.0478787637665503 0.831716894621477 -3.27162305036256 4.8883208620152e-18 miRNATAP -0.23775995157646 0.00318184372631022 NA NA NA hsa-miR-129-5p ADAM12 -0.405735314747643 0.341485636033577 2.40624900645293 4.34494698353113e-09 miRanda;mirMAP -0.122860127180156 0.00662034386831729 NA NA NA hsa-miR-139-5p ADAM12 -2.26625553116965 7.22375119369519e-16 2.40624900645293 4.34494698353113e-09 miRanda -0.393532964665707 1.5758357910704e-09 NA NA NA hsa-miR-186-5p ADAM12 0.852175445703945 6.88885738584309e-10 2.40624900645293 4.34494698353113e-09 mirMAP -0.476202418509167 0.000565636084977687 NA NA NA hsa-miR-26a-5p ADAM12 -0.126411409001078 0.440028840408711 2.40624900645293 4.34494698353113e-09 mirMAP;miRNATAP -0.505768357416581 1.78713133438295e-05 NA NA NA hsa-miR-26b-5p ADAM12 0.72362441215247 4.7794659748036e-05 2.40624900645293 4.34494698353113e-09 mirMAP;miRNATAP -0.403896181895527 0.000173101033832287 NA NA NA hsa-miR-29a-3p ADAM12 0.101650412194573 0.573201097011668 2.40624900645293 4.34494698353113e-09 miRNATAP -0.431548143883598 5.36975047967082e-05 25886595 ADAM12 L is a direct target of the miR 29 and miR 200 families in breast cancer breast cancer hsa-miR-3065-5p ADAM12 0.653308707552535 0.0999497219778851 2.40624900645293 4.34494698353113e-09 mirMAP -0.322462848048877 4.46878214239634e-10 NA NA NA hsa-miR-320a ADAM12 -0.961144925954715 1.62478794429204e-08 2.40624900645293 4.34494698353113e-09 mirMAP -0.345219335770601 0.00204222562499075 NA NA NA hsa-miR-338-3p ADAM12 0.726843067232002 0.0506251324215494 2.40624900645293 4.34494698353113e-09 miRanda -0.317609599079548 3.73140982754685e-10 NA NA NA hsa-miR-3934-5p ADAM12 0.0322530814975441 0.910284056659068 2.40624900645293 4.34494698353113e-09 mirMAP -0.265495411585566 0.000193288675090962 NA NA NA hsa-miR-429 ADAM12 2.3794516574089 1.72813419703734e-13 2.40624900645293 4.34494698353113e-09 miRanda;miRNATAP -0.267814480094255 1.78105833538482e-05 NA NA NA hsa-miR-96-5p ANPEP 3.0381097138467 4.40362891630201e-24 -1.31945334877884 0.000868297148279098 mirMAP -0.319583115640984 1.5181588008438e-06 NA NA NA hsa-miR-107 AREG 0.658676029898313 5.11480446318819e-07 -0.86211359649712 0.0952206389154785 miRanda -0.530492988772643 0.00362095452848057 NA NA NA hsa-miR-326 AREG -0.992397386750901 0.00335173765975096 -0.86211359649712 0.0952206389154785 miRanda -0.268748266879567 0.000119314431697342 NA NA NA hsa-miR-330-5p AREG 0.168520831101569 0.336433937906706 -0.86211359649712 0.0952206389154785 miRanda -0.405900222683146 0.00303456583082398 NA NA NA hsa-miR-429 AREG 2.3794516574089 1.72813419703734e-13 -0.86211359649712 0.0952206389154785 miRanda -0.325650117645307 2.592073703752e-05 NA NA NA hsa-let-7b-3p BASP1 -1.81889978084306 6.9913416210266e-19 1.22558870644166 0.000175037379500842 miRNATAP -0.219844266892316 0.00201617001268263 NA NA NA hsa-miR-139-5p BASP1 -2.26625553116965 7.22375119369519e-16 1.22558870644166 0.000175037379500842 miRanda -0.173033681044976 0.000891381374173396 NA NA NA hsa-miR-146b-3p BASP1 -0.808296168180355 0.000870284326590347 1.22558870644166 0.000175037379500842 PITA;miRNATAP -0.333361860956361 5.91342394864903e-08 NA NA NA hsa-miR-146b-5p BASP1 1.0922867893808 5.63754607494775e-06 1.22558870644166 0.000175037379500842 miRanda -0.243683109857928 8.93185760815632e-05 NA NA NA hsa-miR-150-5p BASP1 -0.702328520623782 0.0215316651134431 1.22558870644166 0.000175037379500842 miRNATAP -0.169110385980588 0.000612435337892018 NA NA NA hsa-miR-10a-5p BDNF 0.790595816051606 0.000593731378445468 -3.58120361925577 1.66270299378731e-16 MirTarget;miRNATAP -0.279836886583095 0.00181387070495345 NA NA NA hsa-miR-146b-5p BDNF 1.0922867893808 5.63754607494775e-06 -3.58120361925577 1.66270299378731e-16 miRanda -0.328233255541106 0.000115785817710226 NA NA NA hsa-miR-148a-5p BDNF 1.45633512586855 1.81792463521257e-08 -3.58120361925577 1.66270299378731e-16 mirMAP -0.242376055234495 0.00212193071916532 NA NA NA hsa-miR-155-5p BDNF 0.813513839059142 0.000608282725633232 -3.58120361925577 1.66270299378731e-16 miRNATAP -0.23365712136721 0.00730981706859504 NA NA NA hsa-miR-15a-5p BDNF 1.62575353599172 1.55312121019827e-19 -3.58120361925577 1.66270299378731e-16 MirTarget;miRNATAP -0.299122819876483 0.00718936325191299 26581909 MicroRNA 15a 5p suppresses cancer proliferation and division in human hepatocellular carcinoma by targeting BDNF; BDNF was then overexpressed in HepG2 and SNU-182 cells to evaluate its selective effect on miR-15a-5p in HCC modulation; MiR-15a-5p selectively and negatively regulated BDNF at both gene and protein levels in HCC cells; Forced overexpression of BDNF effectively reversed the tumor suppressive functions of miR-15a-5p on HCC proliferation and cell division in vitro; Our study demonstrated that miR-15a-5p is a tumor suppressor in HCC and its regulation is through BDNF in HCC liver cancer hsa-miR-182-5p BDNF 3.21839823004635 5.13049145201115e-39 -3.58120361925577 1.66270299378731e-16 MirTarget;miRNATAP -0.493312713509266 7.77762857641849e-11 NA NA NA hsa-miR-210-3p BDNF 4.89285936864822 4.81769290932762e-28 -3.58120361925577 1.66270299378731e-16 miRNAWalker2_validate;miRTarBase -0.223383828264906 2.32341714099671e-07 NA NA NA hsa-miR-29b-1-5p BDNF 1.71024742617744 3.64915691793611e-09 -3.58120361925577 1.66270299378731e-16 mirMAP -0.254685357058655 0.000278466889584519 NA NA NA hsa-miR-30e-5p BDNF 1.60414100786743 3.78951090573667e-19 -3.58120361925577 1.66270299378731e-16 miRNATAP -0.435874001655586 8.84443032504441e-05 NA NA NA hsa-miR-7-1-3p BDNF 2.61364240402652 1.98959237815786e-32 -3.58120361925577 1.66270299378731e-16 MirTarget -0.301669237992761 0.00109301980491166 NA NA NA hsa-miR-330-5p BGN 0.168520831101569 0.336433937906706 0.167724345038758 0.461438189950976 miRanda -0.172857778663542 0.00410928006135691 NA NA NA hsa-miR-29c-3p BMP1 1.32354490728858 1.84279305179762e-07 0.0756172301751175 0.711316723864274 miRNATAP -0.102942429163392 0.00488226338289075 NA NA NA hsa-miR-30b-3p BMP1 -1.20976737190106 2.63726511331003e-06 0.0756172301751175 0.711316723864274 miRNATAP -0.213693040454612 2.02403458767016e-09 NA NA NA hsa-miR-335-5p BMP1 -0.466533891325811 0.0676987038122831 0.0756172301751175 0.711316723864274 miRNAWalker2_validate -0.254107607692475 3.62946531865076e-10 NA NA NA hsa-miR-429 BMP1 2.3794516574089 1.72813419703734e-13 0.0756172301751175 0.711316723864274 miRNATAP -0.122517197337616 6.07472630654849e-05 NA NA NA hsa-miR-92a-1-5p BMP1 -0.206144909572847 0.487857247338839 0.0756172301751175 0.711316723864274 mirMAP -0.104009680568289 0.00140759588159267 NA NA NA hsa-let-7g-3p CADM1 2.38336858943031 4.8771148585792e-17 -1.97539534457883 2.23181309519858e-09 miRNATAP -0.162762850037624 0.00196475615137775 NA NA NA hsa-miR-141-3p CADM1 3.36993755486106 5.42939251147195e-32 -1.97539534457883 2.23181309519858e-09 MirTarget;TargetScan -0.235542466190185 2.51917652401148e-06 NA NA NA hsa-miR-142-5p CADM1 1.29672439149353 4.0768822158894e-06 -1.97539534457883 2.23181309519858e-09 PITA -0.204008312332861 0.000549649249845598 NA NA NA hsa-miR-15a-5p CADM1 1.62575353599172 1.55312121019827e-19 -1.97539534457883 2.23181309519858e-09 miRNAWalker2_validate;miRTarBase;miRNATAP -0.285547709733985 0.000579640124061181 NA NA NA hsa-miR-186-5p CADM1 0.852175445703945 6.88885738584309e-10 -1.97539534457883 2.23181309519858e-09 mirMAP;miRNATAP -0.327323697167292 0.00334749959891919 NA NA NA hsa-miR-192-5p CADM1 2.03412119423736 1.6357945826287e-05 -1.97539534457883 2.23181309519858e-09 miRNAWalker2_validate -0.15046604979345 3.01112257166364e-06 NA NA NA hsa-miR-193a-3p CADM1 0.549173467360291 0.0319030569365466 -1.97539534457883 2.23181309519858e-09 MirTarget;PITA;miRanda;miRNATAP -0.348071588278883 8.53288256099161e-08 NA NA NA hsa-miR-193b-3p CADM1 1.10444771306846 0.000822888533401377 -1.97539534457883 2.23181309519858e-09 MirTarget -0.275005346191019 2.20413555258771e-09 NA NA NA hsa-miR-194-5p CADM1 1.76979641760284 8.2064222072696e-05 -1.97539534457883 2.23181309519858e-09 miRNATAP -0.138655378128794 4.52826816990073e-05 NA NA NA hsa-miR-23a-3p CADM1 0.111958289789488 0.393086414480463 -1.97539534457883 2.23181309519858e-09 miRNATAP -0.495579811935391 3.46765434654936e-05 NA NA NA hsa-miR-27a-3p CADM1 0.433402568013802 0.00737164631768323 -1.97539534457883 2.23181309519858e-09 MirTarget;miRNATAP -0.438259786794973 4.74392124060205e-06 NA NA NA hsa-miR-424-5p CADM1 1.26485330287919 6.1498991028257e-06 -1.97539534457883 2.23181309519858e-09 miRNATAP -0.159537508811877 0.00363105532987234 NA NA NA hsa-miR-590-3p CADM1 0.83851360565783 0.00129224433453587 -1.97539534457883 2.23181309519858e-09 miRanda;mirMAP -0.278969919008543 8.23277795073959e-05 NA NA NA hsa-miR-590-5p CADM1 2.07441240363458 4.95240551694843e-14 -1.97539534457883 2.23181309519858e-09 PITA;miRanda;miRNATAP -0.361847924437666 7.29107941634696e-08 NA NA NA hsa-miR-625-5p CADM1 1.38208523187596 6.28473801440755e-07 -1.97539534457883 2.23181309519858e-09 MirTarget -0.226019297567307 0.000243633098069221 NA NA NA hsa-miR-106a-5p CALD1 1.3902608059488 6.07931522284525e-05 -0.848837150897777 2.47165060879416e-05 miRNATAP -0.167438569455038 1.37856782966188e-08 NA NA NA hsa-miR-106b-5p CALD1 1.47447672652218 1.32004094930462e-13 -0.848837150897777 2.47165060879416e-05 miRNATAP -0.271237229113303 1.88364200908537e-09 NA NA NA hsa-miR-107 CALD1 0.658676029898313 5.11480446318819e-07 -0.848837150897777 2.47165060879416e-05 miRanda -0.434433537822674 6.70753006782834e-10 NA NA NA hsa-miR-146b-5p CALD1 1.0922867893808 5.63754607494775e-06 -0.848837150897777 2.47165060879416e-05 miRanda -0.101448080100428 0.00848075613565001 NA NA NA hsa-miR-15a-5p CALD1 1.62575353599172 1.55312121019827e-19 -0.848837150897777 2.47165060879416e-05 miRNAWalker2_validate -0.306833122673322 4.94820569516743e-10 NA NA NA hsa-miR-16-2-3p CALD1 0.503964803530872 0.0263648405197492 -0.848837150897777 2.47165060879416e-05 mirMAP -0.186710350726302 2.75180923242662e-05 NA NA NA hsa-miR-17-5p CALD1 2.07078488653279 2.77403038572568e-19 -0.848837150897777 2.47165060879416e-05 TargetScan;miRNATAP -0.298464914452391 3.13413607702354e-15 NA NA NA hsa-miR-182-5p CALD1 3.21839823004635 5.13049145201115e-39 -0.848837150897777 2.47165060879416e-05 MirTarget -0.228646474667048 2.10797574899758e-11 NA NA NA hsa-miR-20a-5p CALD1 2.64649625616975 5.1469418982085e-27 -0.848837150897777 2.47165060879416e-05 miRNATAP -0.274217309916258 3.56276430068535e-15 NA NA NA hsa-miR-21-5p CALD1 4.38165933891779 1.52536633902505e-92 -0.848837150897777 2.47165060879416e-05 miRNAWalker2_validate;MirTarget -0.120939783944041 0.000651247883014593 NA NA NA hsa-miR-3065-5p CALD1 0.653308707552535 0.0999497219778851 -0.848837150897777 2.47165060879416e-05 mirMAP -0.143117104007823 1.39686930398076e-08 NA NA NA hsa-miR-338-3p CALD1 0.726843067232002 0.0506251324215494 -0.848837150897777 2.47165060879416e-05 miRanda -0.1053096761462 2.39200869775559e-05 NA NA NA hsa-miR-34a-5p CALD1 1.40588612517769 8.60097477768592e-12 -0.848837150897777 2.47165060879416e-05 miRNAWalker2_validate -0.221418239252969 5.10581098068918e-07 NA NA NA hsa-miR-429 CALD1 2.3794516574089 1.72813419703734e-13 -0.848837150897777 2.47165060879416e-05 miRanda -0.235742941623462 1.78233759205481e-15 NA NA NA hsa-miR-501-3p CALD1 -0.0405952693028064 0.866802243505833 -0.848837150897777 2.47165060879416e-05 TargetScan;miRNATAP -0.117381911543489 0.00241153049063667 NA NA NA hsa-miR-590-3p CALD1 0.83851360565783 0.00129224433453587 -0.848837150897777 2.47165060879416e-05 miRanda;mirMAP -0.154706378751609 0.000297969954999876 NA NA NA hsa-miR-590-5p CALD1 2.07441240363458 4.95240551694843e-14 -0.848837150897777 2.47165060879416e-05 miRanda -0.200447804707821 8.03649556796534e-07 NA NA NA hsa-miR-93-5p CALD1 1.50844106515467 1.83836866996875e-12 -0.848837150897777 2.47165060879416e-05 miRNATAP -0.297047735064435 1.11160256500784e-12 NA NA NA hsa-let-7a-5p CALU -1.37014061604018 3.11451492971224e-14 0.702693034395063 3.10548392061848e-05 TargetScan -0.129923079157519 0.00214920511310059 NA NA NA hsa-miR-103a-3p CALU 0.538497806383155 1.88134691850591e-05 0.702693034395063 3.10548392061848e-05 miRNAWalker2_validate;MirTarget -0.268411869686937 1.69788812739308e-05 NA NA NA hsa-miR-125b-2-3p CALU -1.71462405245374 1.47042341386638e-10 0.702693034395063 3.10548392061848e-05 MirTarget -0.1433354914656 4.46423594941072e-07 NA NA NA hsa-miR-150-5p CALU -0.702328520623782 0.0215316651134431 0.702693034395063 3.10548392061848e-05 MirTarget -0.101178693819624 6.97683301729342e-05 NA NA NA hsa-miR-15a-5p CALU 1.62575353599172 1.55312121019827e-19 0.702693034395063 3.10548392061848e-05 MirTarget -0.141377851305114 0.000741561997849374 NA NA NA hsa-miR-15b-5p CALU -1.25935038177398 1.83460220856901e-12 0.702693034395063 3.10548392061848e-05 MirTarget -0.134177147136651 0.00177328585452876 NA NA NA hsa-miR-181a-5p CALU -0.375429731222937 0.0562142867129802 0.702693034395063 3.10548392061848e-05 mirMAP -0.215028038271715 5.184908150345e-08 NA NA NA hsa-miR-181c-5p CALU 0.529875814537156 0.0125885822998008 0.702693034395063 3.10548392061848e-05 mirMAP -0.220089422188908 1.37972214598144e-09 NA NA NA hsa-miR-195-5p CALU -1.01577502605386 4.80814718341729e-05 0.702693034395063 3.10548392061848e-05 MirTarget -0.16740663083288 2.56397572332854e-07 NA NA NA hsa-miR-200b-3p CALU 1.55157578247391 4.83790020897188e-09 0.702693034395063 3.10548392061848e-05 MirTarget;TargetScan -0.176570286374208 6.39533500356099e-10 NA NA NA hsa-miR-200c-3p CALU 0.380533388300368 0.0842181838538353 0.702693034395063 3.10548392061848e-05 MirTarget -0.155134670444002 1.15853918823698e-05 NA NA NA hsa-miR-29c-3p CALU 1.32354490728858 1.84279305179762e-07 0.702693034395063 3.10548392061848e-05 MirTarget -0.151135716224057 5.47684093019302e-07 NA NA NA hsa-miR-30a-3p CALU -2.54042202792785 2.9111625410859e-18 0.702693034395063 3.10548392061848e-05 MirTarget -0.154346461408752 1.26152317231621e-09 NA NA NA hsa-miR-30a-5p CALU -0.924084264430689 0.000762030454634728 0.702693034395063 3.10548392061848e-05 MirTarget -0.24597360079396 2.03015500931758e-19 NA NA NA hsa-miR-30b-5p CALU 0.358144314839612 0.138026229059594 0.702693034395063 3.10548392061848e-05 MirTarget -0.279755108244311 3.41085862485003e-19 NA NA NA hsa-miR-30c-5p CALU -0.327319105755825 0.123595832152687 0.702693034395063 3.10548392061848e-05 MirTarget -0.343230174864723 2.30096142103796e-22 NA NA NA hsa-miR-30d-3p CALU 0.00396376345349925 0.986457040013182 0.702693034395063 3.10548392061848e-05 MirTarget -0.274361342420275 8.19734498790025e-14 NA NA NA hsa-miR-30d-5p CALU -0.920901858717441 3.50898334321668e-05 0.702693034395063 3.10548392061848e-05 MirTarget -0.333413090775297 1.40844833382539e-23 NA NA NA hsa-miR-30e-5p CALU 1.60414100786743 3.78951090573667e-19 0.702693034395063 3.10548392061848e-05 MirTarget -0.126213605129468 0.00272088794510959 NA NA NA hsa-miR-320a CALU -0.961144925954715 1.62478794429204e-08 0.702693034395063 3.10548392061848e-05 miRNAWalker2_validate -0.134402060448595 0.00319501593737395 NA NA NA hsa-miR-335-5p CALU -0.466533891325811 0.0676987038122831 0.702693034395063 3.10548392061848e-05 MirTarget -0.106757347920317 0.00184577415158127 NA NA NA hsa-miR-338-5p CALU -1.83316380675941 4.03269924759167e-07 0.702693034395063 3.10548392061848e-05 mirMAP -0.113317636642175 7.7162017514819e-08 NA NA NA hsa-miR-374a-5p CALU -0.197027254874826 0.298080902192861 0.702693034395063 3.10548392061848e-05 mirMAP -0.242313786864772 1.47988493315464e-07 NA NA NA hsa-miR-375 CALU 0.615547997686534 0.149199273675144 0.702693034395063 3.10548392061848e-05 miRNAWalker2_validate -0.110502965497315 8.34044658536964e-10 NA NA NA hsa-miR-429 CALU 2.3794516574089 1.72813419703734e-13 0.702693034395063 3.10548392061848e-05 MirTarget;PITA;miRanda -0.124064241156227 9.711030377695e-07 NA NA NA hsa-miR-497-5p CALU -0.0546347378264729 0.786205564901684 0.702693034395063 3.10548392061848e-05 MirTarget -0.22982569841649 2.34688517497621e-09 NA NA NA hsa-miR-335-3p CAP2 1.51116383169018 6.88553098788624e-13 -0.432121460557303 0.0579493045910775 mirMAP -0.140018407493394 0.00410937961080584 NA NA NA hsa-miR-429 CAP2 2.3794516574089 1.72813419703734e-13 -0.432121460557303 0.0579493045910775 miRanda -0.123875206540284 0.00029316178715651 NA NA NA hsa-miR-29a-5p CD44 1.89519956688438 1.03453349363915e-11 -1.314849769491 7.50296611362024e-09 mirMAP -0.128677165130321 0.00400178149905116 NA NA NA hsa-miR-330-5p CD44 0.168520831101569 0.336433937906706 -1.314849769491 7.50296611362024e-09 miRanda -0.161128703892305 0.00855400991007469 NA NA NA hsa-miR-421 CD44 0.170525317701774 0.535277026680289 -1.314849769491 7.50296611362024e-09 miRanda -0.15412421571464 0.000244521242618069 NA NA NA hsa-miR-141-3p CD59 3.36993755486106 5.42939251147195e-32 -1.04030708295214 3.01831914118236e-08 mirMAP -0.170192869423648 1.42501757522434e-09 NA NA NA hsa-miR-182-5p CD59 3.21839823004635 5.13049145201115e-39 -1.04030708295214 3.01831914118236e-08 MirTarget -0.135752169151598 2.99706174916902e-05 NA NA NA hsa-miR-335-3p CD59 1.51116383169018 6.88553098788624e-13 -1.04030708295214 3.01831914118236e-08 mirMAP -0.337077826343799 1.14022835163894e-17 NA NA NA hsa-miR-590-3p CD59 0.83851360565783 0.00129224433453587 -1.04030708295214 3.01831914118236e-08 mirMAP -0.126407572812369 0.00167971259977596 NA NA NA hsa-miR-766-3p CD59 0.0784037775118556 0.760091599198293 -1.04030708295214 3.01831914118236e-08 MirTarget -0.137964455941506 5.19212183015762e-05 NA NA NA hsa-miR-92a-3p CD59 -0.136362762339122 0.493412263619364 -1.04030708295214 3.01831914118236e-08 miRNAWalker2_validate -0.248709815767589 1.3020463987375e-08 NA NA NA hsa-miR-130b-3p CDH11 1.83046548750752 5.04753914574694e-13 -0.308435871234897 0.244295005746204 mirMAP -0.243657725991275 6.81735557606225e-07 NA NA NA hsa-miR-16-2-3p CDH11 0.503964803530872 0.0263648405197492 -0.308435871234897 0.244295005746204 mirMAP -0.339387718625774 3.83409239397093e-09 NA NA NA hsa-miR-200b-3p CDH11 1.55157578247391 4.83790020897188e-09 -0.308435871234897 0.244295005746204 TargetScan -0.242765278223546 5.8085132294582e-08 NA NA NA hsa-miR-301a-3p CDH11 2.70198002906399 1.56420889710984e-14 -0.308435871234897 0.244295005746204 mirMAP -0.224668338740779 5.12509448374314e-08 NA NA NA hsa-miR-320b CDH11 0.226640952564488 0.378818692487242 -0.308435871234897 0.244295005746204 miRanda -0.144731188747124 0.00227015604255366 NA NA NA hsa-miR-335-5p CDH11 -0.466533891325811 0.0676987038122831 -0.308435871234897 0.244295005746204 miRNAWalker2_validate -0.234522501027826 1.03249504485575e-05 NA NA NA hsa-miR-362-3p CDH11 0.194097672030785 0.52808475179225 -0.308435871234897 0.244295005746204 miRanda -0.238026324674486 1.32653867609267e-06 NA NA NA hsa-miR-421 CDH11 0.170525317701774 0.535277026680289 -0.308435871234897 0.244295005746204 miRanda -0.276832977411105 6.02453469325903e-09 NA NA NA hsa-miR-429 CDH11 2.3794516574089 1.72813419703734e-13 -0.308435871234897 0.244295005746204 PITA;miRanda -0.233525798017063 2.71227239231656e-09 NA NA NA hsa-miR-454-3p CDH11 1.49453641052169 4.46235742871434e-09 -0.308435871234897 0.244295005746204 mirMAP -0.376636770978389 9.61391221620221e-12 NA NA NA hsa-miR-500a-5p CDH11 0.648155655714409 0.0104657432932038 -0.308435871234897 0.244295005746204 mirMAP -0.303031888204147 4.65603333179416e-10 NA NA NA hsa-miR-576-5p CDH11 1.02693643167056 1.14846964470173e-06 -0.308435871234897 0.244295005746204 PITA;mirMAP;miRNATAP -0.367436315389649 6.63882977542527e-11 NA NA NA hsa-miR-590-3p CDH11 0.83851360565783 0.00129224433453587 -0.308435871234897 0.244295005746204 miRanda;mirMAP -0.249416490224949 7.35298321134727e-06 NA NA NA hsa-miR-7-1-3p CDH11 2.61364240402652 1.98959237815786e-32 -0.308435871234897 0.244295005746204 mirMAP -0.264640903816888 9.44211999511487e-07 NA NA NA hsa-miR-26a-5p CDH2 -0.126411409001078 0.440028840408711 0.208460444138559 0.682352061982617 miRNATAP -0.494609072495664 0.000614175362243147 NA NA NA hsa-miR-26b-5p CDH2 0.72362441215247 4.7794659748036e-05 0.208460444138559 0.682352061982617 miRNATAP -0.430483001612156 0.00106176812538378 NA NA NA hsa-miR-3065-5p CDH2 0.653308707552535 0.0999497219778851 0.208460444138559 0.682352061982617 miRNATAP -0.35314747059789 2.50039287959045e-08 NA NA NA hsa-miR-30a-5p CDH2 -0.924084264430689 0.000762030454634728 0.208460444138559 0.682352061982617 miRNAWalker2_validate -0.379476439212042 7.10815174417084e-06 21633953 Consistent with this microRNA-30a expression was found inversely proportional to the invasive potential of various NSCLC cell lines correlating positively with E-cadherin epithelial marker and negatively with N-cadherin mesenchymal marker expression lung squamous cell cancer hsa-miR-452-5p CDH2 0.637123950346362 0.0458173998136196 0.208460444138559 0.682352061982617 miRNATAP -0.310124958258816 2.1511111341596e-05 NA NA NA hsa-miR-155-5p CDH6 0.813513839059142 0.000608282725633232 -1.47491765638883 1.62481173331278e-06 miRNAWalker2_validate -0.161302695731872 0.00739314635837093 NA NA NA hsa-miR-15b-3p CDH6 0.804736041893915 0.000400279611457186 -1.47491765638883 1.62481173331278e-06 mirMAP -0.252303062479066 0.000133855020719702 NA NA NA hsa-miR-186-5p CDH6 0.852175445703945 6.88885738584309e-10 -1.47491765638883 1.62481173331278e-06 mirMAP -0.583036393405292 1.03961566016766e-08 NA NA NA hsa-miR-20a-3p CDH6 2.51803599558247 4.92479325298629e-13 -1.47491765638883 1.62481173331278e-06 mirMAP -0.294877165824151 7.75931475668832e-09 NA NA NA hsa-miR-24-2-5p CDH6 1.43704663046967 4.34375016509278e-11 -1.47491765638883 1.62481173331278e-06 MirTarget -0.198463152409443 0.0020765148199215 NA NA NA hsa-miR-29a-5p CDH6 1.89519956688438 1.03453349363915e-11 -1.47491765638883 1.62481173331278e-06 mirMAP -0.338244257600242 1.22381797273004e-08 NA NA NA hsa-miR-335-3p CDH6 1.51116383169018 6.88553098788624e-13 -1.47491765638883 1.62481173331278e-06 mirMAP -0.282317128364982 2.01436124608049e-05 NA NA NA hsa-miR-339-5p CDH6 0.536997313601114 0.0488090394176611 -1.47491765638883 1.62481173331278e-06 miRanda -0.254990798658347 9.90409118740122e-07 NA NA NA hsa-miR-450b-5p CDH6 1.69248953402469 1.96052058003353e-07 -1.47491765638883 1.62481173331278e-06 mirMAP;miRNATAP -0.188294197132397 0.000100334978941839 NA NA NA hsa-miR-501-3p CDH6 -0.0405952693028064 0.866802243505833 -1.47491765638883 1.62481173331278e-06 MirTarget -0.234610109439878 7.25869820172689e-05 NA NA NA hsa-miR-502-3p CDH6 -0.262270070977708 0.161760375279961 -1.47491765638883 1.62481173331278e-06 MirTarget -0.239549621553849 0.00182188937571911 NA NA NA hsa-miR-542-3p CDH6 1.62226640768239 2.6427102465476e-10 -1.47491765638883 1.62481173331278e-06 miRanda -0.185574874241607 0.000686129470671782 NA NA NA hsa-miR-576-5p CDH6 1.02693643167056 1.14846964470173e-06 -1.47491765638883 1.62481173331278e-06 PITA;mirMAP -0.292300612821938 1.2659305958122e-05 NA NA NA hsa-miR-590-3p CDH6 0.83851360565783 0.00129224433453587 -1.47491765638883 1.62481173331278e-06 miRanda -0.255078119281878 9.92337939932393e-05 NA NA NA hsa-miR-664a-3p CDH6 0.443077463053857 0.0214248925850984 -1.47491765638883 1.62481173331278e-06 mirMAP -0.263556869860617 0.000402743167173429 NA NA NA hsa-miR-7-1-3p CDH6 2.61364240402652 1.98959237815786e-32 -1.47491765638883 1.62481173331278e-06 mirMAP -0.275965586320185 1.42528680959668e-05 NA NA NA hsa-let-7a-5p COL11A1 -1.37014061604018 3.11451492971224e-14 5.23228286350859 2.85537482242574e-12 TargetScan -1.22688359207895 7.12892362645136e-11 NA NA NA hsa-miR-126-5p COL11A1 0.851637714492907 0.000391373420568359 5.23228286350859 2.85537482242574e-12 MirTarget;mirMAP -0.660638673398049 5.91589295436195e-06 NA NA NA hsa-miR-129-5p COL11A1 -0.405735314747643 0.341485636033577 5.23228286350859 2.85537482242574e-12 PITA;miRanda;mirMAP;miRNATAP -0.246494712320926 0.00307711362863776 NA NA NA hsa-miR-139-5p COL11A1 -2.26625553116965 7.22375119369519e-16 5.23228286350859 2.85537482242574e-12 miRanda -0.906690983537481 2.19872516403893e-14 NA NA NA hsa-miR-195-3p COL11A1 -1.33068822339418 6.65427393047357e-09 5.23228286350859 2.85537482242574e-12 MirTarget -0.564475518248944 0.000206327047691498 NA NA NA hsa-miR-200a-3p COL11A1 3.14766878548496 1.32850889777422e-21 5.23228286350859 2.85537482242574e-12 miRNATAP -0.286623800422845 0.00637303745981239 NA NA NA hsa-miR-200c-5p COL11A1 1.7188514281688 1.38603090488265e-12 5.23228286350859 2.85537482242574e-12 MirTarget;miRNATAP -0.410306141033963 0.00401621939662809 NA NA NA hsa-miR-26a-5p COL11A1 -0.126411409001078 0.440028840408711 5.23228286350859 2.85537482242574e-12 miRNATAP -0.978362423046049 6.48079472118884e-06 NA NA NA hsa-miR-26b-5p COL11A1 0.72362441215247 4.7794659748036e-05 5.23228286350859 2.85537482242574e-12 miRNATAP -0.58179400347401 0.00340916969558828 NA NA NA hsa-miR-29a-3p COL11A1 0.101650412194573 0.573201097011668 5.23228286350859 2.85537482242574e-12 MirTarget;miRNATAP -0.761845167228566 0.000109576278673345 NA NA NA hsa-miR-29c-3p COL11A1 1.32354490728858 1.84279305179762e-07 5.23228286350859 2.85537482242574e-12 MirTarget;miRNATAP -0.370988120343184 0.00711305092510534 NA NA NA hsa-miR-3065-3p COL11A1 0.381740717819351 0.30795546546997 5.23228286350859 2.85537482242574e-12 MirTarget;miRNATAP -0.708449833841292 1.25843489122145e-14 NA NA NA hsa-miR-335-5p COL11A1 -0.466533891325811 0.0676987038122831 5.23228286350859 2.85537482242574e-12 miRNAWalker2_validate -1.15348401601652 2.36077775638976e-14 NA NA NA hsa-miR-362-3p COL11A1 0.194097672030785 0.52808475179225 5.23228286350859 2.85537482242574e-12 miRanda -0.428143065806304 0.00293834326769485 NA NA NA hsa-miR-374a-5p COL11A1 -0.197027254874826 0.298080902192861 5.23228286350859 2.85537482242574e-12 mirMAP -0.886405375179343 2.37398301043604e-05 NA NA NA hsa-miR-664a-3p COL11A1 0.443077463053857 0.0214248925850984 5.23228286350859 2.85537482242574e-12 mirMAP -0.620473124689845 0.000751553024416148 NA NA NA hsa-miR-92a-3p COL11A1 -0.136362762339122 0.493412263619364 5.23228286350859 2.85537482242574e-12 MirTarget -0.559294270503641 0.00173988225188321 NA NA NA hsa-miR-107 COL12A1 0.658676029898313 5.11480446318819e-07 -0.849027180514303 0.034965601861609 miRanda -0.824824021381213 4.041853055058e-09 NA NA NA hsa-miR-1180-3p COL12A1 -0.436557784255953 0.0682615670979027 -0.849027180514303 0.034965601861609 MirTarget -0.27043087875248 0.00048567890056969 NA NA NA hsa-miR-126-5p COL12A1 0.851637714492907 0.000391373420568359 -0.849027180514303 0.034965601861609 mirMAP -0.22772513093558 0.00311617062183821 NA NA NA hsa-miR-15a-5p COL12A1 1.62575353599172 1.55312121019827e-19 -0.849027180514303 0.034965601861609 MirTarget;miRNATAP -0.426797033405239 1.6711310547343e-05 NA NA NA hsa-miR-15b-5p COL12A1 -1.25935038177398 1.83460220856901e-12 -0.849027180514303 0.034965601861609 MirTarget;miRNATAP -0.338146898230106 0.000902952096841043 NA NA NA hsa-miR-16-5p COL12A1 0.749619098384047 4.11649450706988e-06 -0.849027180514303 0.034965601861609 MirTarget;miRNATAP -0.602147905536878 9.33094829038679e-08 NA NA NA hsa-miR-17-3p COL12A1 1.36706429551147 4.60388403547821e-13 -0.849027180514303 0.034965601861609 MirTarget;miRNATAP -0.459960829699226 1.46700926135531e-06 NA NA NA hsa-miR-26a-5p COL12A1 -0.126411409001078 0.440028840408711 -0.849027180514303 0.034965601861609 miRNATAP -0.354982549299829 0.00193539103088857 NA NA NA hsa-miR-26b-5p COL12A1 0.72362441215247 4.7794659748036e-05 -0.849027180514303 0.034965601861609 miRNATAP -0.429354526578486 3.5343924060556e-05 NA NA NA hsa-miR-30a-3p COL12A1 -2.54042202792785 2.9111625410859e-18 -0.849027180514303 0.034965601861609 miRNATAP -0.20604974080763 0.000759106802003022 NA NA NA hsa-miR-30a-5p COL12A1 -0.924084264430689 0.000762030454634728 -0.849027180514303 0.034965601861609 mirMAP -0.368598490160908 3.07423944692291e-08 NA NA NA hsa-miR-30b-5p COL12A1 0.358144314839612 0.138026229059594 -0.849027180514303 0.034965601861609 mirMAP -0.516393444187054 7.97187898166328e-12 NA NA NA hsa-miR-30c-5p COL12A1 -0.327319105755825 0.123595832152687 -0.849027180514303 0.034965601861609 mirMAP -0.457212176411143 1.37795709268694e-07 NA NA NA hsa-miR-30d-3p COL12A1 0.00396376345349925 0.986457040013182 -0.849027180514303 0.034965601861609 miRNATAP -0.656235502268262 5.32358246284361e-14 NA NA NA hsa-miR-30d-5p COL12A1 -0.920901858717441 3.50898334321668e-05 -0.849027180514303 0.034965601861609 mirMAP -0.628855279686375 6.91227138947358e-15 NA NA NA hsa-miR-32-5p COL12A1 0.876853679269853 6.04859399018691e-05 -0.849027180514303 0.034965601861609 miRNATAP -0.443179749419632 1.15507268014881e-06 NA NA NA hsa-miR-335-3p COL12A1 1.51116383169018 6.88553098788624e-13 -0.849027180514303 0.034965601861609 mirMAP -0.32833052588044 0.000135184764730393 NA NA NA hsa-miR-338-3p COL12A1 0.726843067232002 0.0506251324215494 -0.849027180514303 0.034965601861609 miRanda -0.263816303425525 8.6669217144582e-08 NA NA NA hsa-miR-34a-5p COL12A1 1.40588612517769 8.60097477768592e-12 -0.849027180514303 0.034965601861609 MirTarget;miRNATAP -0.282347433473276 0.00139939749950768 NA NA NA hsa-miR-375 COL12A1 0.615547997686534 0.149199273675144 -0.849027180514303 0.034965601861609 miRNAWalker2_validate -0.266273953854135 4.60862443000385e-10 NA NA NA hsa-miR-501-3p COL12A1 -0.0405952693028064 0.866802243505833 -0.849027180514303 0.034965601861609 PITA -0.224647306798835 0.00351185956560443 NA NA NA hsa-miR-502-3p COL12A1 -0.262270070977708 0.161760375279961 -0.849027180514303 0.034965601861609 PITA -0.593162518565679 1.5427543111899e-09 NA NA NA hsa-miR-532-5p COL12A1 0.576620898517708 0.0023245812680956 -0.849027180514303 0.034965601861609 PITA -0.569816758138048 4.11788744789386e-09 NA NA NA hsa-miR-92a-3p COL12A1 -0.136362762339122 0.493412263619364 -0.849027180514303 0.034965601861609 miRNATAP -0.279498671332033 0.00288272723919442 NA NA NA hsa-let-7a-5p COL1A1 -1.37014061604018 3.11451492971224e-14 2.42065146814761 3.39003531025036e-11 TargetScan;miRNATAP -0.596721970344643 6.93515424395411e-11 NA NA NA hsa-let-7b-5p COL1A1 -1.62016148171663 1.56547487335694e-15 2.42065146814761 3.39003531025036e-11 miRNATAP -0.29948836737854 0.000262649270813065 NA NA NA hsa-let-7d-5p COL1A1 -0.618145137285851 6.06067642715858e-05 2.42065146814761 3.39003531025036e-11 miRNATAP -0.555394166436726 5.59530512629896e-07 NA NA NA hsa-let-7f-5p COL1A1 -0.0523311272618407 0.83407808268787 2.42065146814761 3.39003531025036e-11 miRNATAP -0.352705898260858 2.48056064656299e-07 NA NA NA hsa-let-7g-5p COL1A1 0.0837630831079359 0.583083118232597 2.42065146814761 3.39003531025036e-11 miRNATAP -0.569787034491876 4.66938321096021e-07 NA NA NA hsa-miR-107 COL1A1 0.658676029898313 5.11480446318819e-07 2.42065146814761 3.39003531025036e-11 PITA;miRanda -0.66134725787987 4.00003936521905e-07 NA NA NA hsa-miR-133a-3p COL1A1 -2.89609207852024 1.71222048144972e-13 2.42065146814761 3.39003531025036e-11 miRNAWalker2_validate -0.138993476526241 0.00112688010552943 NA NA NA hsa-miR-30a-3p COL1A1 -2.54042202792785 2.9111625410859e-18 2.42065146814761 3.39003531025036e-11 mirMAP -0.435571026514716 2.87112040151015e-15 NA NA NA hsa-miR-30b-3p COL1A1 -1.20976737190106 2.63726511331003e-06 2.42065146814761 3.39003531025036e-11 miRNATAP -0.364433820785245 2.55880839848639e-08 NA NA NA hsa-miR-30d-3p COL1A1 0.00396376345349925 0.986457040013182 2.42065146814761 3.39003531025036e-11 mirMAP -0.592265244784086 2.46968154677536e-13 NA NA NA hsa-miR-30e-3p COL1A1 -0.104420043859122 0.526240453209293 2.42065146814761 3.39003531025036e-11 mirMAP -0.555277449194079 1.02221283405107e-07 NA NA NA hsa-miR-330-3p COL1A1 -0.716924999893351 0.000796236278616087 2.42065146814761 3.39003531025036e-11 mirMAP -0.315399409772296 8.16900883661461e-05 NA NA NA hsa-miR-338-3p COL1A1 0.726843067232002 0.0506251324215494 2.42065146814761 3.39003531025036e-11 miRanda;miRNATAP -0.178951913488227 9.9215993656662e-05 NA NA NA hsa-miR-361-3p COL1A1 0.0988926195529967 0.549128728500555 2.42065146814761 3.39003531025036e-11 PITA -0.323853876550334 0.00207476620275568 NA NA NA hsa-miR-92a-1-5p COL1A1 -0.206144909572847 0.487857247338839 2.42065146814761 3.39003531025036e-11 MirTarget -0.164842138542065 0.00578612315198288 NA NA NA hsa-let-7a-5p COL1A2 -1.37014061604018 3.11451492971224e-14 0.876118168211992 0.00368711342738012 MirTarget;TargetScan;miRNATAP -0.241702341970535 0.00135789667212977 NA NA NA hsa-let-7d-5p COL1A2 -0.618145137285851 6.06067642715858e-05 0.876118168211992 0.00368711342738012 MirTarget;miRNATAP -0.355761625090553 8.33642750132082e-05 NA NA NA hsa-let-7f-5p COL1A2 -0.0523311272618407 0.83407808268787 0.876118168211992 0.00368711342738012 MirTarget;miRNATAP -0.201184305177655 0.000313423714809636 NA NA NA hsa-let-7g-5p COL1A2 0.0837630831079359 0.583083118232597 0.876118168211992 0.00368711342738012 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.378077277130448 4.02146869124637e-05 NA NA NA hsa-miR-19b-3p COL1A2 2.10868505662119 5.40846613768389e-17 0.876118168211992 0.00368711342738012 MirTarget -0.148917788523693 0.00837087535968672 NA NA NA hsa-miR-25-3p COL1A2 0.361927330834176 0.0163670566170988 0.876118168211992 0.00368711342738012 MirTarget;miRNATAP -0.388368128679851 2.92439361890388e-05 NA NA NA hsa-miR-26a-5p COL1A2 -0.126411409001078 0.440028840408711 0.876118168211992 0.00368711342738012 MirTarget;miRNATAP -0.253542314755959 0.00320050316582886 NA NA NA hsa-miR-26b-5p COL1A2 0.72362441215247 4.7794659748036e-05 0.876118168211992 0.00368711342738012 MirTarget;miRNATAP -0.281535684852185 0.000312672991159713 NA NA NA hsa-miR-29a-3p COL1A2 0.101650412194573 0.573201097011668 0.876118168211992 0.00368711342738012 miRNATAP -0.203669541999129 0.00897188032974133 NA NA NA hsa-miR-30a-3p COL1A2 -2.54042202792785 2.9111625410859e-18 0.876118168211992 0.00368711342738012 MirTarget -0.230071837954876 4.51147879508592e-07 NA NA NA hsa-miR-30d-3p COL1A2 0.00396376345349925 0.986457040013182 0.876118168211992 0.00368711342738012 MirTarget -0.473963376561583 5.15302527439975e-13 NA NA NA hsa-miR-30e-3p COL1A2 -0.104420043859122 0.526240453209293 0.876118168211992 0.00368711342738012 MirTarget -0.39466193610838 3.31645249106772e-06 NA NA NA hsa-miR-32-5p COL1A2 0.876853679269853 6.04859399018691e-05 0.876118168211992 0.00368711342738012 MirTarget;miRNATAP -0.26757902412027 9.88080962911513e-05 NA NA NA hsa-miR-3934-5p COL1A2 0.0322530814975441 0.910284056659068 0.876118168211992 0.00368711342738012 MirTarget -0.235659314209142 4.73939812028552e-06 NA NA NA hsa-miR-500a-5p COL1A2 0.648155655714409 0.0104657432932038 0.876118168211992 0.00368711342738012 miRNATAP -0.199136328717997 0.000414600401117691 NA NA NA hsa-miR-92a-3p COL1A2 -0.136362762339122 0.493412263619364 0.876118168211992 0.00368711342738012 MirTarget;miRNATAP -0.277447300018764 7.67027357501172e-05 NA NA NA hsa-let-7a-5p COL3A1 -1.37014061604018 3.11451492971224e-14 1.93994440720887 6.00406603287404e-09 MirTarget;TargetScan;miRNATAP -0.376816865985439 7.44871676595992e-06 NA NA NA hsa-let-7c-5p COL3A1 -2.14139413005852 1.66416999341685e-18 1.93994440720887 6.00406603287404e-09 MirTarget -0.189437773779812 0.00211669549744929 NA NA NA hsa-let-7d-5p COL3A1 -0.618145137285851 6.06067642715858e-05 1.93994440720887 6.00406603287404e-09 MirTarget;miRNATAP -0.416264122679282 3.92898511477105e-05 NA NA NA hsa-let-7f-5p COL3A1 -0.0523311272618407 0.83407808268787 1.93994440720887 6.00406603287404e-09 MirTarget;miRNATAP -0.227888492049675 0.000268639023930012 NA NA NA hsa-let-7g-5p COL3A1 0.0837630831079359 0.583083118232597 1.93994440720887 6.00406603287404e-09 MirTarget;miRNATAP -0.432145188495893 2.78688634997935e-05 NA NA NA hsa-miR-107 COL3A1 0.658676029898313 5.11480446318819e-07 1.93994440720887 6.00406603287404e-09 miRanda -0.558435166682454 2.56220963341249e-06 NA NA NA hsa-miR-186-5p COL3A1 0.852175445703945 6.88885738584309e-10 1.93994440720887 6.00406603287404e-09 miRNATAP -0.409414798189994 0.000264826695544128 NA NA NA hsa-miR-29a-3p COL3A1 0.101650412194573 0.573201097011668 1.93994440720887 6.00406603287404e-09 MirTarget;miRNATAP -0.242052966664795 0.00555685987872576 NA NA NA hsa-miR-335-5p COL3A1 -0.466533891325811 0.0676987038122831 1.93994440720887 6.00406603287404e-09 miRNAWalker2_validate -0.460621896185065 6.89433672520812e-12 NA NA NA hsa-miR-429 COL3A1 2.3794516574089 1.72813419703734e-13 1.93994440720887 6.00406603287404e-09 miRanda -0.219340430897579 1.54842519775806e-05 NA NA NA hsa-let-7f-5p COL4A1 -0.0523311272618407 0.83407808268787 -0.171188584989235 0.444957041661407 miRNATAP -0.119613217283808 0.00383589608321452 NA NA NA hsa-let-7g-5p COL4A1 0.0837630831079359 0.583083118232597 -0.171188584989235 0.444957041661407 miRNATAP -0.24497162186823 0.000328807573938744 NA NA NA hsa-miR-16-5p COL4A1 0.749619098384047 4.11649450706988e-06 -0.171188584989235 0.444957041661407 miRNAWalker2_validate -0.305665949761596 1.10858365302114e-06 NA NA NA hsa-miR-29a-3p COL4A1 0.101650412194573 0.573201097011668 -0.171188584989235 0.444957041661407 miRNAWalker2_validate;miRTarBase;miRNATAP -0.231277342972376 5.47658398396484e-05 NA NA NA hsa-miR-29b-3p COL4A1 3.10527711861309 3.01242507282711e-32 -0.171188584989235 0.444957041661407 miRNAWalker2_validate;miRTarBase;miRNATAP -0.169878075822688 2.87223680838542e-06 NA NA NA hsa-miR-29c-3p COL4A1 1.32354490728858 1.84279305179762e-07 -0.171188584989235 0.444957041661407 miRNAWalker2_validate;miRTarBase;miRNATAP -0.183472319048058 4.15003522961556e-06 NA NA NA hsa-miR-3065-5p COL4A1 0.653308707552535 0.0999497219778851 -0.171188584989235 0.444957041661407 miRNATAP -0.135591684821414 1.24639892231323e-06 NA NA NA hsa-miR-362-3p COL4A1 0.194097672030785 0.52808475179225 -0.171188584989235 0.444957041661407 miRanda -0.134753411115438 0.00129947643192595 NA NA NA hsa-miR-429 COL4A1 2.3794516574089 1.72813419703734e-13 -0.171188584989235 0.444957041661407 miRanda;miRNATAP -0.194737605606394 4.50254748904607e-09 NA NA NA hsa-miR-628-5p COL4A1 1.06173574237323 4.67541261016756e-06 -0.171188584989235 0.444957041661407 PITA;miRNATAP -0.137894538435734 0.00915566627512573 NA NA NA hsa-let-7f-5p COL4A2 -0.0523311272618407 0.83407808268787 -0.618750645591112 0.00595258274491188 miRNATAP -0.174516107539413 2.57998374267252e-05 NA NA NA hsa-let-7g-5p COL4A2 0.0837630831079359 0.583083118232597 -0.618750645591112 0.00595258274491188 miRNATAP -0.280315504842131 4.36950007027574e-05 NA NA NA hsa-miR-1266-5p COL4A2 -0.289721391624349 0.281500764553995 -0.618750645591112 0.00595258274491188 MirTarget -0.102157435637751 0.0082695589651559 NA NA NA hsa-miR-16-5p COL4A2 0.749619098384047 4.11649450706988e-06 -0.618750645591112 0.00595258274491188 miRNAWalker2_validate -0.32451853983148 2.74433880065982e-07 NA NA NA hsa-miR-26b-5p COL4A2 0.72362441215247 4.7794659748036e-05 -0.618750645591112 0.00595258274491188 miRNAWalker2_validate -0.235865417887102 4.86776153058155e-05 NA NA NA hsa-miR-29a-3p COL4A2 0.101650412194573 0.573201097011668 -0.618750645591112 0.00595258274491188 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.239057796585856 3.4644745560624e-05 NA NA NA hsa-miR-29b-3p COL4A2 3.10527711861309 3.01242507282711e-32 -0.618750645591112 0.00595258274491188 miRTarBase;MirTarget;miRNATAP -0.162304699728469 9.32896919724563e-06 NA NA NA hsa-miR-29c-3p COL4A2 1.32354490728858 1.84279305179762e-07 -0.618750645591112 0.00595258274491188 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.189027420859138 2.47820806738349e-06 NA NA NA hsa-miR-107 COL5A1 0.658676029898313 5.11480446318819e-07 1.56547504280567 2.15706253605725e-07 miRanda -0.52911553686772 7.51141882492598e-07 NA NA NA hsa-miR-25-3p COL5A1 0.361927330834176 0.0163670566170988 1.56547504280567 2.15706253605725e-07 miRNATAP -0.38856355094064 3.51503585607746e-05 NA NA NA hsa-miR-26a-5p COL5A1 -0.126411409001078 0.440028840408711 1.56547504280567 2.15706253605725e-07 miRNATAP -0.287347840568329 0.000932321553623759 NA NA NA hsa-miR-26b-5p COL5A1 0.72362441215247 4.7794659748036e-05 1.56547504280567 2.15706253605725e-07 miRNAWalker2_validate;miRNATAP -0.252184900544277 0.00142025889885729 NA NA NA hsa-miR-29a-3p COL5A1 0.101650412194573 0.573201097011668 1.56547504280567 2.15706253605725e-07 MirTarget;miRNATAP -0.247216628919756 0.00166610387784759 NA NA NA hsa-miR-3065-3p COL5A1 0.381740717819351 0.30795546546997 1.56547504280567 2.15706253605725e-07 miRNATAP -0.177908158162349 1.84843789921432e-06 NA NA NA hsa-miR-32-5p COL5A1 0.876853679269853 6.04859399018691e-05 1.56547504280567 2.15706253605725e-07 miRNATAP -0.239707644210795 0.000569520191476546 NA NA NA hsa-miR-338-5p COL5A1 -1.83316380675941 4.03269924759167e-07 1.56547504280567 2.15706253605725e-07 miRNATAP -0.188273173478317 7.65767781408535e-07 NA NA NA hsa-miR-92a-3p COL5A1 -0.136362762339122 0.493412263619364 1.56547504280567 2.15706253605725e-07 miRNATAP -0.264511123919736 0.000193365991410257 NA NA NA hsa-let-7a-5p COL5A2 -1.37014061604018 3.11451492971224e-14 1.54608581592264 2.70167580251027e-07 MirTarget;TargetScan;miRNATAP -0.385932824888064 2.91793537563896e-07 NA NA NA hsa-let-7c-5p COL5A2 -2.14139413005852 1.66416999341685e-18 1.54608581592264 2.70167580251027e-07 MirTarget -0.219750204419374 6.74750139457207e-05 NA NA NA hsa-let-7d-5p COL5A2 -0.618145137285851 6.06067642715858e-05 1.54608581592264 2.70167580251027e-07 MirTarget;miRNATAP -0.454150444569699 5.19265185569017e-07 NA NA NA hsa-let-7f-5p COL5A2 -0.0523311272618407 0.83407808268787 1.54608581592264 2.70167580251027e-07 MirTarget;miRNATAP -0.237294134819017 2.26450919807127e-05 NA NA NA hsa-let-7g-5p COL5A2 0.0837630831079359 0.583083118232597 1.54608581592264 2.70167580251027e-07 MirTarget;miRNATAP -0.460173617635251 6.04220968557161e-07 NA NA NA hsa-miR-29a-3p COL5A2 0.101650412194573 0.573201097011668 1.54608581592264 2.70167580251027e-07 MirTarget;miRNATAP -0.290164585398726 0.000203325865990868 NA NA NA hsa-miR-3065-5p COL5A2 0.653308707552535 0.0999497219778851 1.54608581592264 2.70167580251027e-07 MirTarget;mirMAP -0.233790630962676 5.94812213140922e-10 NA NA NA hsa-miR-30a-3p COL5A2 -2.54042202792785 2.9111625410859e-18 1.54608581592264 2.70167580251027e-07 mirMAP -0.326391619437187 5.29848432734411e-13 NA NA NA hsa-miR-30e-3p COL5A2 -0.104420043859122 0.526240453209293 1.54608581592264 2.70167580251027e-07 mirMAP -0.462867294575973 5.18065706086594e-08 NA NA NA hsa-miR-335-5p COL5A2 -0.466533891325811 0.0676987038122831 1.54608581592264 2.70167580251027e-07 miRNATAP -0.441214186893916 2.03947428157641e-13 NA NA NA hsa-miR-338-5p COL5A2 -1.83316380675941 4.03269924759167e-07 1.54608581592264 2.70167580251027e-07 mirMAP -0.220969220432077 4.64111419305357e-09 NA NA NA hsa-miR-29a-3p COL5A3 0.101650412194573 0.573201097011668 0.259751908187821 0.438101249376702 MirTarget;miRNATAP -0.234445715741372 0.00650773606405499 NA NA NA hsa-miR-29c-3p COL5A3 1.32354490728858 1.84279305179762e-07 0.259751908187821 0.438101249376702 MirTarget;miRNATAP -0.155802301942085 0.00950228629575243 NA NA NA hsa-miR-3065-3p COL5A3 0.381740717819351 0.30795546546997 0.259751908187821 0.438101249376702 MirTarget;miRNATAP -0.223475237507239 3.88040998029192e-08 NA NA NA hsa-miR-429 COL5A3 2.3794516574089 1.72813419703734e-13 0.259751908187821 0.438101249376702 miRanda -0.236618347287441 2.20617431869806e-06 NA NA NA hsa-miR-429 COL6A3 2.3794516574089 1.72813419703734e-13 0.753849546647885 0.0047129103584608 miRNATAP -0.213509526010052 8.19960803625876e-08 NA NA NA hsa-miR-29a-3p COL7A1 0.101650412194573 0.573201097011668 3.06133719412201 8.31133965720386e-09 MirTarget;miRNATAP -0.498393487253349 0.000325690731603303 NA NA NA hsa-miR-3065-3p COL7A1 0.381740717819351 0.30795546546997 3.06133719412201 8.31133965720386e-09 MirTarget;miRNATAP -0.320669643936385 1.12274107695441e-06 NA NA NA hsa-miR-106a-5p COL8A2 1.3902608059488 6.07931522284525e-05 -0.0795993667759127 0.795878173191613 mirMAP -0.194462740905877 1.57795054136297e-05 NA NA NA hsa-miR-106b-5p COL8A2 1.47447672652218 1.32004094930462e-13 -0.0795993667759127 0.795878173191613 mirMAP -0.431317114066589 2.70682718554714e-10 NA NA NA hsa-miR-17-5p COL8A2 2.07078488653279 2.77403038572568e-19 -0.0795993667759127 0.795878173191613 mirMAP -0.390415157243462 1.52882416020176e-11 NA NA NA hsa-miR-20a-5p COL8A2 2.64649625616975 5.1469418982085e-27 -0.0795993667759127 0.795878173191613 mirMAP -0.315762488555537 3.79576059791458e-09 NA NA NA hsa-miR-335-5p COL8A2 -0.466533891325811 0.0676987038122831 -0.0795993667759127 0.795878173191613 miRNAWalker2_validate -0.443346385267097 2.65011250021381e-13 NA NA NA hsa-miR-3614-5p COL8A2 -1.19394699210224 2.53933783780868e-05 -0.0795993667759127 0.795878173191613 MirTarget;miRNATAP -0.153587801734704 0.00196290318989537 NA NA NA hsa-miR-582-5p COL8A2 1.08286181406653 0.00149040450161757 -0.0795993667759127 0.795878173191613 PITA -0.31759235086565 1.39182082019577e-14 NA NA NA hsa-miR-16-2-3p CTGF 0.503964803530872 0.0263648405197492 -1.93919990217197 1.23139457575587e-12 MirTarget -0.19323825832132 0.00175521750530604 NA NA NA hsa-miR-18a-5p CTGF 1.37435209536521 9.2173853686829e-06 -1.93919990217197 1.23139457575587e-12 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.212240225387845 1.7430616244331e-06 23249750 Targeting of TGFβ signature and its essential component CTGF by miR 18 correlates with improved survival in glioblastoma; Indeed microRNA-18a but not other miR-17∼92 members has a functional site in the CTGF 3' UTR and its forced reexpression sharply reduces CTGF protein and mRNA levels; The unexpected effects of miR-18a on CTGF transcription are mediated in part by direct targeting of Smad3 and ensuing weakening of TGFβ signaling poor survival glioblastoma hsa-miR-19a-3p CTGF 2.11776595911517 7.07663078397156e-10 -1.93919990217197 1.23139457575587e-12 MirTarget;miRNATAP -0.251352682939966 7.22225795499269e-09 NA NA NA hsa-miR-19b-3p CTGF 2.10868505662119 5.40846613768389e-17 -1.93919990217197 1.23139457575587e-12 MirTarget;miRNATAP -0.330005606313434 1.25796573303135e-10 NA NA NA hsa-miR-26b-3p CTGF 1.37388760789373 8.32526977075803e-09 -1.93919990217197 1.23139457575587e-12 MirTarget;miRNATAP -0.160488447596543 0.00260563510076072 25761878 Luciferase reporter assay confirmed the interaction of miR-26b with the 3' untranslated regions UTRs of CTGF and Smad1 sarcoma hsa-miR-3065-5p CTGF 0.653308707552535 0.0999497219778851 -1.93919990217197 1.23139457575587e-12 MirTarget;miRNATAP -0.168583438955929 1.46806495242491e-06 NA NA NA hsa-miR-590-3p CTGF 0.83851360565783 0.00129224433453587 -1.93919990217197 1.23139457575587e-12 PITA;miRanda -0.1889416678022 0.00140691509980854 NA NA NA hsa-miR-7-1-3p CTGF 2.61364240402652 1.98959237815786e-32 -1.93919990217197 1.23139457575587e-12 MirTarget -0.334460512582212 3.85772558267046e-09 NA NA NA hsa-miR-30a-5p CTHRC1 -0.924084264430689 0.000762030454634728 3.34933532951563 2.55557432589795e-21 MirTarget -0.653466214242413 2.47572860010169e-29 NA NA NA hsa-miR-30b-5p CTHRC1 0.358144314839612 0.138026229059594 3.34933532951563 2.55557432589795e-21 MirTarget -0.408025204708013 4.92886071947753e-09 26388700 MiR-30b was down-regulated and Cthrc1 up-regulated in NSCLC tissues; Bioinformatics analysis identified Cthrc1 as a target of miR-30b and western blotting and luciferase reporter assays confirmed that miR-30b regulates Cthrc1 by directly binding to its 3'UTR; Transfection of Cthrc1 without the 3'UTR restored the miR-30b inhibiting cell invasion; Up-regulation of miR-30b or down-regulation of Cthrc1 had potential significance in the invasion and metastasis of NSCLC; MiR-30b was down-regulated and Cthrc1 up-regulated in NSCLC tissues; MiR-30b affected NSCLC cells invasion and migration by regulating Cthrc1 metastasis lung squamous cell cancer hsa-miR-30c-5p CTHRC1 -0.327319105755825 0.123595832152687 3.34933532951563 2.55557432589795e-21 MirTarget -0.633786101316744 4.6864662964238e-16 NA NA NA hsa-miR-30d-5p CTHRC1 -0.920901858717441 3.50898334321668e-05 3.34933532951563 2.55557432589795e-21 MirTarget -0.768271773718993 1.67091432386487e-26 NA NA NA hsa-miR-335-5p CTHRC1 -0.466533891325811 0.0676987038122831 3.34933532951563 2.55557432589795e-21 miRNAWalker2_validate -0.379810175608259 2.92309634670469e-07 NA NA NA hsa-miR-141-3p CXCL12 3.36993755486106 5.42939251147195e-32 -1.73860088459961 4.38087111236691e-09 miRNATAP -0.40588823313909 7.29402344621355e-21 NA NA NA hsa-miR-16-2-3p CXCL12 0.503964803530872 0.0263648405197492 -1.73860088459961 4.38087111236691e-09 mirMAP -0.208989401479966 0.00165931679611056 NA NA NA hsa-miR-186-5p CXCL12 0.852175445703945 6.88885738584309e-10 -1.73860088459961 4.38087111236691e-09 mirMAP -0.423978431377939 2.01683441113194e-05 NA NA NA hsa-miR-200a-3p CXCL12 3.14766878548496 1.32850889777422e-21 -1.73860088459961 4.38087111236691e-09 miRNATAP -0.292527343428127 3.56066508810111e-13 NA NA NA hsa-miR-301a-3p CXCL12 2.70198002906399 1.56420889710984e-14 -1.73860088459961 4.38087111236691e-09 miRNATAP -0.238808565525885 3.8560296916956e-07 NA NA NA hsa-miR-375 CXCL12 0.615547997686534 0.149199273675144 -1.73860088459961 4.38087111236691e-09 PITA;miRanda -0.12223783030977 0.000157650812393918 NA NA NA hsa-miR-429 CXCL12 2.3794516574089 1.72813419703734e-13 -1.73860088459961 4.38087111236691e-09 miRanda;miRNATAP -0.316440658393871 9.36676398222456e-13 NA NA NA hsa-miR-450b-5p CXCL12 1.69248953402469 1.96052058003353e-07 -1.73860088459961 4.38087111236691e-09 mirMAP -0.142655621690588 0.00242956876361258 NA NA NA hsa-miR-590-3p CXCL12 0.83851360565783 0.00129224433453587 -1.73860088459961 4.38087111236691e-09 PITA;miRanda;mirMAP -0.196190046424295 0.00206556624669133 NA NA NA hsa-miR-625-5p CXCL12 1.38208523187596 6.28473801440755e-07 -1.73860088459961 4.38087111236691e-09 MirTarget -0.147855181161825 0.00759427514174653 NA NA NA hsa-miR-96-5p CXCL12 3.0381097138467 4.40362891630201e-24 -1.73860088459961 4.38087111236691e-09 mirMAP -0.396760759442405 7.24012134033737e-16 NA NA NA hsa-miR-338-5p CXCL6 -1.83316380675941 4.03269924759167e-07 0.513452705359912 0.414166175861713 mirMAP -0.256517528503988 0.00113914686958388 NA NA NA hsa-miR-375 CXCL6 0.615547997686534 0.149199273675144 0.513452705359912 0.414166175861713 miRanda -0.202767422109154 0.0027341296047302 NA NA NA hsa-miR-331-5p CYR61 0.578237334664505 0.00131211239210882 -1.67307872396367 6.17825216358867e-10 miRNATAP -0.207780865892589 0.00421552436724855 NA NA NA hsa-miR-429 CYR61 2.3794516574089 1.72813419703734e-13 -1.67307872396367 6.17825216358867e-10 miRanda -0.181995304991661 1.01178363656773e-05 NA NA NA hsa-miR-106a-5p DAB2 1.3902608059488 6.07931522284525e-05 -1.34680688439788 6.0477977497076e-11 MirTarget;miRNATAP -0.200508313456404 4.18949009433051e-11 NA NA NA hsa-miR-106b-5p DAB2 1.47447672652218 1.32004094930462e-13 -1.34680688439788 6.0477977497076e-11 MirTarget;miRNATAP -0.443951774155157 1.26631057105568e-22 26769181 The expression of the miR-106b target gene DAB2 in human cervical tissues and cell lines were measured by qRT-PCR western blot and immunohistochemistry; DAB2 a predicted target gene of miR-106b was inhibited by TGF-β1 partly through miR-106b and was involved in TGF-β1-induced cervical cancer cell migration; The expression of DAB2 was low in cervical cancer tissues and negatively correlated with miR-106b expression cell migration cervical and endocervical cancer hsa-miR-17-5p DAB2 2.07078488653279 2.77403038572568e-19 -1.34680688439788 6.0477977497076e-11 MirTarget;TargetScan;miRNATAP -0.371186222503171 7.12847073318907e-22 NA NA NA hsa-miR-186-5p DAB2 0.852175445703945 6.88885738584309e-10 -1.34680688439788 6.0477977497076e-11 MirTarget;mirMAP -0.32392434433245 2.88011264317122e-06 NA NA NA hsa-miR-20a-5p DAB2 2.64649625616975 5.1469418982085e-27 -1.34680688439788 6.0477977497076e-11 MirTarget;miRNATAP -0.301744440423878 4.78258882109073e-17 NA NA NA hsa-miR-20b-5p DAB2 1.35770573270947 0.00260808530013016 -1.34680688439788 6.0477977497076e-11 MirTarget;miRNATAP -0.112589377102354 4.5074025050376e-07 NA NA NA hsa-miR-26b-5p DAB2 0.72362441215247 4.7794659748036e-05 -1.34680688439788 6.0477977497076e-11 miRNAWalker2_validate -0.171845111750605 0.00155532726109765 NA NA NA hsa-miR-28-5p DAB2 1.19639196514745 4.59365801666536e-18 -1.34680688439788 6.0477977497076e-11 miRanda -0.23648215678448 0.000529882113747487 NA NA NA hsa-miR-320b DAB2 0.226640952564488 0.378818692487242 -1.34680688439788 6.0477977497076e-11 PITA;miRanda;miRNATAP -0.111457103247369 0.0030751928259289 NA NA NA hsa-miR-331-5p DAB2 0.578237334664505 0.00131211239210882 -1.34680688439788 6.0477977497076e-11 PITA -0.275635009984094 5.05232374301529e-07 NA NA NA hsa-miR-339-5p DAB2 0.536997313601114 0.0488090394176611 -1.34680688439788 6.0477977497076e-11 miRanda -0.127542694007526 0.000316890433108291 NA NA NA hsa-miR-421 DAB2 0.170525317701774 0.535277026680289 -1.34680688439788 6.0477977497076e-11 miRanda -0.114921428419603 0.00268700708688537 NA NA NA hsa-miR-590-3p DAB2 0.83851360565783 0.00129224433453587 -1.34680688439788 6.0477977497076e-11 miRanda;mirMAP -0.226417974241286 2.69083821494827e-07 NA NA NA hsa-miR-590-5p DAB2 2.07441240363458 4.95240551694843e-14 -1.34680688439788 6.0477977497076e-11 miRanda -0.33203166849992 7.84247533918661e-16 NA NA NA hsa-miR-93-5p DAB2 1.50844106515467 1.83836866996875e-12 -1.34680688439788 6.0477977497076e-11 MirTarget;miRNATAP -0.3887753042744 6.1441874085525e-20 24037530 miR 93 directed downregulation of DAB2 defines a novel oncogenic pathway in lung cancer; We next identify that microRNA miR-93 functions as a potent repressor of DAB2 expression by directly targeting the 3'UTR of the DAB2 mRNA; Using in vitro and in vivo approaches we demonstrate that miR-93 overexpression has an important role in promoting lung cancer cell growth and that its oncogenic function is primarily mediated by downregulating DAB2 expression; The correlations of both low DAB2 and high miR-93 expression levels with poor patient survival strongly support the critical role of the miR-93/DAB2 pathway in determining lung cancer progression progression;poor survival lung cancer hsa-miR-96-5p DAB2 3.0381097138467 4.40362891630201e-24 -1.34680688439788 6.0477977497076e-11 MirTarget;TargetScan -0.394065269353064 5.85093010454081e-33 NA NA NA hsa-miR-181b-5p DCN 0.668793269169928 0.000239998092406404 -2.00595264323545 3.24853890265267e-13 MirTarget -0.202381391616366 0.00470398821242922 NA NA NA hsa-miR-186-5p DCN 0.852175445703945 6.88885738584309e-10 -2.00595264323545 3.24853890265267e-13 mirMAP -0.549470336361193 2.86699652578085e-09 NA NA NA hsa-miR-320b DCN 0.226640952564488 0.378818692487242 -2.00595264323545 3.24853890265267e-13 miRanda -0.141878627206176 0.00514027543744941 NA NA NA hsa-miR-421 DCN 0.170525317701774 0.535277026680289 -2.00595264323545 3.24853890265267e-13 miRanda -0.28010859453059 3.86446078575396e-08 NA NA NA hsa-miR-501-5p DCN 0.411357595674671 0.10435288464149 -2.00595264323545 3.24853890265267e-13 mirMAP -0.25564025069398 5.48491293930464e-07 NA NA NA hsa-miR-590-3p DCN 0.83851360565783 0.00129224433453587 -2.00595264323545 3.24853890265267e-13 MirTarget;PITA;miRanda;mirMAP -0.269373987573071 5.82985439043145e-06 NA NA NA hsa-miR-7-1-3p DCN 2.61364240402652 1.98959237815786e-32 -2.00595264323545 3.24853890265267e-13 mirMAP -0.438646941994977 9.07416983404945e-15 NA NA NA hsa-miR-107 DPYSL3 0.658676029898313 5.11480446318819e-07 -0.30538807435271 0.226900925848309 miRanda -0.319324381925401 0.000325013317690612 NA NA NA hsa-miR-1266-5p DPYSL3 -0.289721391624349 0.281500764553995 -0.30538807435271 0.226900925848309 MirTarget -0.257162968735029 1.65053886002867e-09 NA NA NA hsa-miR-141-3p DPYSL3 3.36993755486106 5.42939251147195e-32 -0.30538807435271 0.226900925848309 TargetScan -0.206173279196154 3.58688595380235e-08 NA NA NA hsa-miR-141-5p DPYSL3 3.02575703771074 1.54385222591327e-32 -0.30538807435271 0.226900925848309 MirTarget -0.240669523329312 9.870868962893e-09 NA NA NA hsa-miR-26b-5p DPYSL3 0.72362441215247 4.7794659748036e-05 -0.30538807435271 0.226900925848309 miRNAWalker2_validate -0.21621556016595 0.000917397685346749 NA NA NA hsa-miR-29b-3p DPYSL3 3.10527711861309 3.01242507282711e-32 -0.30538807435271 0.226900925848309 MirTarget -0.160454106232454 9.50496191282739e-05 NA NA NA hsa-miR-335-3p DPYSL3 1.51116383169018 6.88553098788624e-13 -0.30538807435271 0.226900925848309 mirMAP -0.193474400213319 0.000333425645394311 NA NA NA hsa-miR-338-5p DPYSL3 -1.83316380675941 4.03269924759167e-07 -0.30538807435271 0.226900925848309 PITA -0.189009573610452 1.44328406109031e-09 NA NA NA hsa-miR-362-3p DPYSL3 0.194097672030785 0.52808475179225 -0.30538807435271 0.226900925848309 PITA;miRanda;miRNATAP -0.160729549946206 0.0006703443403008 NA NA NA hsa-miR-532-3p DPYSL3 -0.677758187385834 0.0147557885796065 -0.30538807435271 0.226900925848309 miRNATAP -0.109116592464558 0.00906964718779074 NA NA NA hsa-miR-590-3p DPYSL3 0.83851360565783 0.00129224433453587 -0.30538807435271 0.226900925848309 miRanda;mirMAP -0.15223486549192 0.0043700923650848 NA NA NA hsa-miR-106a-5p DST 1.3902608059488 6.07931522284525e-05 -1.46697088328632 7.81274276497184e-08 mirMAP -0.117045251562207 0.0041306908735368 NA NA NA hsa-miR-106b-5p DST 1.47447672652218 1.32004094930462e-13 -1.46697088328632 7.81274276497184e-08 mirMAP -0.28790916229393 3.61316416821258e-06 NA NA NA hsa-miR-130b-5p DST 1.53645187062942 1.10498816261505e-08 -1.46697088328632 7.81274276497184e-08 mirMAP -0.16419568802038 0.000427286061683538 NA NA NA hsa-miR-141-3p DST 3.36993755486106 5.42939251147195e-32 -1.46697088328632 7.81274276497184e-08 mirMAP -0.283047301870988 3.30152139295434e-12 NA NA NA hsa-miR-17-3p DST 1.36706429551147 4.60388403547821e-13 -1.46697088328632 7.81274276497184e-08 mirMAP;miRNATAP -0.333118466067935 3.67632106021487e-07 NA NA NA hsa-miR-17-5p DST 2.07078488653279 2.77403038572568e-19 -1.46697088328632 7.81274276497184e-08 mirMAP -0.265951006846367 4.52414300872852e-07 NA NA NA hsa-miR-183-5p DST 2.39247234736657 3.92444525331999e-21 -1.46697088328632 7.81274276497184e-08 mirMAP -0.349389181106706 9.8104186057391e-14 NA NA NA hsa-miR-186-5p DST 0.852175445703945 6.88885738584309e-10 -1.46697088328632 7.81274276497184e-08 mirMAP -0.281592840737616 0.00216825783046593 NA NA NA hsa-miR-18a-5p DST 1.37435209536521 9.2173853686829e-06 -1.46697088328632 7.81274276497184e-08 mirMAP -0.18940623425825 1.67120091614354e-05 NA NA NA hsa-miR-19b-1-5p DST 1.71217036351784 3.28561659177495e-12 -1.46697088328632 7.81274276497184e-08 mirMAP -0.262440324932488 6.71097784381917e-06 NA NA NA hsa-miR-200a-3p DST 3.14766878548496 1.32850889777422e-21 -1.46697088328632 7.81274276497184e-08 mirMAP -0.21157347251766 1.52027446123718e-08 NA NA NA hsa-miR-200b-3p DST 1.55157578247391 4.83790020897188e-09 -1.46697088328632 7.81274276497184e-08 mirMAP -0.214910117799302 4.89229775225843e-06 NA NA NA hsa-miR-200c-3p DST 0.380533388300368 0.0842181838538353 -1.46697088328632 7.81274276497184e-08 mirMAP -0.304017590602596 1.20325677189183e-07 NA NA NA hsa-miR-20a-3p DST 2.51803599558247 4.92479325298629e-13 -1.46697088328632 7.81274276497184e-08 mirMAP -0.190637387519593 3.24001106037183e-05 NA NA NA hsa-miR-20a-5p DST 2.64649625616975 5.1469418982085e-27 -1.46697088328632 7.81274276497184e-08 mirMAP -0.21602074210152 9.05775487910937e-06 NA NA NA hsa-miR-21-5p DST 4.38165933891779 1.52536633902505e-92 -1.46697088328632 7.81274276497184e-08 mirMAP -0.163198782248462 0.000758017564884143 22403704 While the EDCs and estrogen similarly altered the expression of multiple microRNAs in MCF-7 cells including miR-21 differential patterns of microRNA expression were induced by DDT and BPA compared to estrogen breast cancer hsa-miR-26b-3p DST 1.37388760789373 8.32526977075803e-09 -1.46697088328632 7.81274276497184e-08 mirMAP -0.17374477147291 0.000969071969493018 NA NA NA hsa-miR-26b-5p DST 0.72362441215247 4.7794659748036e-05 -1.46697088328632 7.81274276497184e-08 mirMAP;miRNATAP -0.187774902604624 0.00881413488234532 NA NA NA hsa-miR-29a-5p DST 1.89519956688438 1.03453349363915e-11 -1.46697088328632 7.81274276497184e-08 mirMAP -0.188600089939277 0.000417155086143111 NA NA NA hsa-miR-29b-1-5p DST 1.71024742617744 3.64915691793611e-09 -1.46697088328632 7.81274276497184e-08 mirMAP -0.124188963871084 0.00408924885127837 NA NA NA hsa-miR-30d-3p DST 0.00396376345349925 0.986457040013182 -1.46697088328632 7.81274276497184e-08 mirMAP -0.258050468489955 2.44362794400846e-05 NA NA NA hsa-miR-32-5p DST 0.876853679269853 6.04859399018691e-05 -1.46697088328632 7.81274276497184e-08 miRNAWalker2_validate;mirMAP -0.257543741430204 4.13699756876499e-05 NA NA NA hsa-miR-335-3p DST 1.51116383169018 6.88553098788624e-13 -1.46697088328632 7.81274276497184e-08 mirMAP -0.251471159034123 2.00463250946235e-05 NA NA NA hsa-miR-33a-5p DST 2.80127809675219 5.09053890529424e-12 -1.46697088328632 7.81274276497184e-08 mirMAP -0.128673718103278 0.000698134430000828 NA NA NA hsa-miR-345-5p DST 1.48924745604581 1.54134850666509e-06 -1.46697088328632 7.81274276497184e-08 mirMAP -0.157060209357428 0.000107295725188269 NA NA NA hsa-miR-429 DST 2.3794516574089 1.72813419703734e-13 -1.46697088328632 7.81274276497184e-08 miRanda;mirMAP;miRNATAP -0.192096676500145 3.4392612170793e-06 NA NA NA hsa-miR-590-3p DST 0.83851360565783 0.00129224433453587 -1.46697088328632 7.81274276497184e-08 PITA;miRanda;mirMAP -0.197995531113375 0.000708741787764453 NA NA NA hsa-miR-590-5p DST 2.07441240363458 4.95240551694843e-14 -1.46697088328632 7.81274276497184e-08 mirMAP -0.174001584818197 0.00186088160120483 NA NA NA hsa-miR-629-3p DST 1.31892116211001 0.000114487182853678 -1.46697088328632 7.81274276497184e-08 mirMAP -0.185613523820246 3.34615166462381e-06 NA NA NA hsa-miR-629-5p DST 1.31657090341737 1.45711558652127e-12 -1.46697088328632 7.81274276497184e-08 mirMAP -0.327143649587879 9.36060645502117e-07 NA NA NA hsa-miR-664a-3p DST 0.443077463053857 0.0214248925850984 -1.46697088328632 7.81274276497184e-08 mirMAP -0.189300311076126 0.00441196064283777 NA NA NA hsa-miR-708-3p DST 3.43841959417743 4.40027692981683e-28 -1.46697088328632 7.81274276497184e-08 MirTarget -0.182751250889019 1.78942708978421e-05 NA NA NA hsa-miR-92b-3p DST 0.0478787637665503 0.831716894621477 -1.46697088328632 7.81274276497184e-08 mirMAP -0.233542424177877 3.66513497997314e-05 NA NA NA hsa-miR-93-5p DST 1.50844106515467 1.83836866996875e-12 -1.46697088328632 7.81274276497184e-08 mirMAP -0.212007920029016 0.000266982441257665 NA NA NA hsa-miR-142-3p ECM2 3.98476449801341 1.56256182021111e-35 -1.68593472060476 1.38700343931273e-10 miRanda;miRNATAP -0.157477841868329 8.59400728361886e-06 NA NA NA hsa-miR-16-2-3p ECM2 0.503964803530872 0.0263648405197492 -1.68593472060476 1.38700343931273e-10 mirMAP -0.370103227450117 1.99119513474597e-10 NA NA NA hsa-miR-331-5p ECM2 0.578237334664505 0.00131211239210882 -1.68593472060476 1.38700343931273e-10 MirTarget -0.341526950256289 1.08546768277265e-06 NA NA NA hsa-miR-335-3p ECM2 1.51116383169018 6.88553098788624e-13 -1.68593472060476 1.38700343931273e-10 MirTarget -0.417455722508452 8.77742642081221e-14 NA NA NA hsa-miR-421 ECM2 0.170525317701774 0.535277026680289 -1.68593472060476 1.38700343931273e-10 miRanda -0.241004036569227 6.5277098411697e-07 NA NA NA hsa-miR-590-3p ECM2 0.83851360565783 0.00129224433453587 -1.68593472060476 1.38700343931273e-10 MirTarget;miRanda;miRNATAP -0.2995022357036 9.35706020568924e-08 NA NA NA hsa-miR-590-5p ECM2 2.07441240363458 4.95240551694843e-14 -1.68593472060476 1.38700343931273e-10 miRanda -0.4388193770158 5.87136356109214e-17 NA NA NA hsa-miR-7-1-3p ECM2 2.61364240402652 1.98959237815786e-32 -1.68593472060476 1.38700343931273e-10 MirTarget -0.414598825855758 1.09561399400583e-14 NA NA NA hsa-miR-107 EDIL3 0.658676029898313 5.11480446318819e-07 -1.62721020554667 2.30031854926051e-05 miRanda -0.760793172836742 1.75371571979487e-08 NA NA NA hsa-miR-16-2-3p EDIL3 0.503964803530872 0.0263648405197492 -1.62721020554667 2.30031854926051e-05 mirMAP -0.501903231727056 2.66271123240207e-09 NA NA NA hsa-miR-182-5p EDIL3 3.21839823004635 5.13049145201115e-39 -1.62721020554667 2.30031854926051e-05 MirTarget -0.294866877898801 8.25635080519437e-06 NA NA NA hsa-miR-186-5p EDIL3 0.852175445703945 6.88885738584309e-10 -1.62721020554667 2.30031854926051e-05 mirMAP -0.706724251567999 2.68924792994404e-08 NA NA NA hsa-miR-21-5p EDIL3 4.38165933891779 1.52536633902505e-92 -1.62721020554667 2.30031854926051e-05 miRNAWalker2_validate;MirTarget -0.296332683082282 1.15045032277474e-05 NA NA NA hsa-miR-29b-1-5p EDIL3 1.71024742617744 3.64915691793611e-09 -1.62721020554667 2.30031854926051e-05 MirTarget -0.289157792636474 1.48058877414535e-06 NA NA NA hsa-miR-335-3p EDIL3 1.51116383169018 6.88553098788624e-13 -1.62721020554667 2.30031854926051e-05 MirTarget -0.232881149554311 0.00502154628910394 NA NA NA hsa-miR-374a-5p EDIL3 -0.197027254874826 0.298080902192861 -1.62721020554667 2.30031854926051e-05 mirMAP -0.290893440083888 0.00627074215506715 NA NA NA hsa-miR-425-5p EDIL3 1.21659524959201 8.01126418494715e-09 -1.62721020554667 2.30031854926051e-05 MirTarget -0.450476212848072 5.01824196851539e-08 NA NA NA hsa-miR-501-5p EDIL3 0.411357595674671 0.10435288464149 -1.62721020554667 2.30031854926051e-05 mirMAP -0.405888215188867 5.55837374500111e-09 NA NA NA hsa-miR-590-3p EDIL3 0.83851360565783 0.00129224433453587 -1.62721020554667 2.30031854926051e-05 miRanda;mirMAP -0.353573862006528 1.44666890945187e-05 NA NA NA hsa-miR-590-5p EDIL3 2.07441240363458 4.95240551694843e-14 -1.62721020554667 2.30031854926051e-05 MirTarget;miRNATAP -0.406435588098272 1.59282521079639e-07 NA NA NA hsa-miR-7-1-3p EDIL3 2.61364240402652 1.98959237815786e-32 -1.62721020554667 2.30031854926051e-05 MirTarget -0.420205448819497 9.92417731734098e-08 NA NA NA hsa-miR-128-3p EFEMP2 1.03509868349735 2.11606310588315e-10 -1.07292913455067 6.68315016752695e-08 miRNAWalker2_validate -0.273920915519483 9.23704594694131e-07 NA NA NA hsa-miR-330-5p EFEMP2 0.168520831101569 0.336433937906706 -1.07292913455067 6.68315016752695e-08 miRanda -0.152909672086377 0.00415078311400085 NA NA NA hsa-miR-421 ELN 0.170525317701774 0.535277026680289 -1.35911344520917 0.000266510704848436 miRanda -0.511054253173539 1.60299180619265e-14 NA NA NA hsa-miR-330-3p ENO2 -0.716924999893351 0.000796236278616087 0.549037356531948 0.0279476674121793 mirMAP;miRNATAP -0.167955732723477 0.00178874782371401 NA NA NA hsa-miR-125a-3p FAP -1.04954492275266 2.45974219476832e-06 1.77247652625425 8.88673082970403e-09 PITA;miRanda;miRNATAP -0.184009874279431 0.00420818572276035 NA NA NA hsa-miR-30a-5p FAP -0.924084264430689 0.000762030454634728 1.77247652625425 8.88673082970403e-09 miRNATAP -0.349374007096435 9.70254712345027e-12 NA NA NA hsa-miR-30c-5p FAP -0.327319105755825 0.123595832152687 1.77247652625425 8.88673082970403e-09 miRNATAP -0.468897033301207 2.01425856324873e-12 NA NA NA hsa-miR-30d-5p FAP -0.920901858717441 3.50898334321668e-05 1.77247652625425 8.88673082970403e-09 miRNATAP -0.588988934915148 1.5052282963701e-21 NA NA NA hsa-miR-338-5p FAP -1.83316380675941 4.03269924759167e-07 1.77247652625425 8.88673082970403e-09 PITA;miRNATAP -0.227639514783687 4.4390664160278e-09 NA NA NA hsa-miR-375 FAP 0.615547997686534 0.149199273675144 1.77247652625425 8.88673082970403e-09 miRanda -0.182066733759125 4.82431179145716e-08 NA NA NA hsa-miR-429 FAP 2.3794516574089 1.72813419703734e-13 1.77247652625425 8.88673082970403e-09 miRNATAP -0.248771711439758 9.59770321080942e-08 NA NA NA hsa-miR-106a-5p FAS 1.3902608059488 6.07931522284525e-05 -0.878746828084236 0.000340153420442741 miRNAWalker2_validate;miRTarBase -0.274948885695996 7.27787651364869e-15 22431000;27142596 miR 106a is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS; Bioinformatic analysis combining with validation experiments identified FAS as a direct target of miR-106a; Moreover a significant inverse correlation was found between miR-106a and FAS expression not only in gastric cancer cell lines but also in gastric cancer specimens; Taken together these findings suggest that ectopicly overexpressed miR-106a may play an oncogenic role in gastric carcinogenesis and impair extrinsic apoptotic pathway through targeting FAS;Functional experiment ascertained that miR-106a interacted with FAS and mediated caspase3 pathway tumorigenesis; gastric cancer;gastric cancer hsa-miR-590-5p FAS 2.07441240363458 4.95240551694843e-14 -0.878746828084236 0.000340153420442741 miRanda -0.282578087201106 9.10535063456113e-09 NA NA NA hsa-miR-107 FBLN1 0.658676029898313 5.11480446318819e-07 -1.76665341168065 4.89605322654061e-11 miRanda -0.522829376803825 4.71240987876119e-08 NA NA NA hsa-miR-429 FBLN1 2.3794516574089 1.72813419703734e-13 -1.76665341168065 4.89605322654061e-11 miRanda -0.194204619000659 2.1754152789441e-06 NA NA NA hsa-miR-335-5p FBLN2 -0.466533891325811 0.0676987038122831 -0.496547375187372 0.0838605204580422 miRNAWalker2_validate -0.305770725084594 1.02182914466014e-07 NA NA NA hsa-miR-200c-3p FBLN5 0.380533388300368 0.0842181838538353 -2.26218753857001 3.41381077159782e-17 miRNAWalker2_validate;miRTarBase -0.235878599520721 4.82834331719248e-05 NA NA NA hsa-miR-429 FBLN5 2.3794516574089 1.72813419703734e-13 -2.26218753857001 3.41381077159782e-17 miRanda;miRNATAP -0.118772604544935 0.0045470969815154 NA NA NA hsa-miR-16-2-3p FBN1 0.503964803530872 0.0263648405197492 -0.23631467770875 0.397554472911853 mirMAP -0.321792139317782 1.29577797384603e-07 NA NA NA hsa-miR-182-5p FBN1 3.21839823004635 5.13049145201115e-39 -0.23631467770875 0.397554472911853 miRNATAP -0.156163008490599 0.00109803033775588 NA NA NA hsa-miR-192-5p FBN1 2.03412119423736 1.6357945826287e-05 -0.23631467770875 0.397554472911853 miRNAWalker2_validate -0.12526065757144 2.79436858066662e-06 NA NA NA hsa-miR-19b-1-5p FBN1 1.71217036351784 3.28561659177495e-12 -0.23631467770875 0.397554472911853 mirMAP -0.312078984735875 9.45677575066111e-08 NA NA NA hsa-miR-25-3p FBN1 0.361927330834176 0.0163670566170988 -0.23631467770875 0.397554472911853 mirMAP -0.396071034971145 3.60165519074952e-06 NA NA NA hsa-miR-29b-3p FBN1 3.10527711861309 3.01242507282711e-32 -0.23631467770875 0.397554472911853 miRNATAP -0.227242146021825 4.93518831452761e-07 NA NA NA hsa-miR-3065-5p FBN1 0.653308707552535 0.0999497219778851 -0.23631467770875 0.397554472911853 mirMAP -0.174680824584293 5.36810880861831e-07 NA NA NA hsa-miR-362-3p FBN1 0.194097672030785 0.52808475179225 -0.23631467770875 0.397554472911853 miRanda;miRNATAP -0.164450753261838 0.00165221646923245 NA NA NA hsa-miR-363-3p FBN1 -0.301366430789287 0.414451883803084 -0.23631467770875 0.397554472911853 mirMAP -0.143259754993691 3.72235534065232e-05 NA NA NA hsa-miR-374a-5p FBN1 -0.197027254874826 0.298080902192861 -0.23631467770875 0.397554472911853 mirMAP -0.200751064100065 0.00880336425903856 NA NA NA hsa-miR-375 FBN1 0.615547997686534 0.149199273675144 -0.23631467770875 0.397554472911853 mirMAP -0.131351551110864 1.10248273942697e-05 NA NA NA hsa-miR-421 FBN1 0.170525317701774 0.535277026680289 -0.23631467770875 0.397554472911853 mirMAP -0.135833167702482 0.00761095610771582 NA NA NA hsa-miR-429 FBN1 2.3794516574089 1.72813419703734e-13 -0.23631467770875 0.397554472911853 miRNATAP -0.269664882436839 6.10870999399535e-11 NA NA NA hsa-miR-576-5p FBN1 1.02693643167056 1.14846964470173e-06 -0.23631467770875 0.397554472911853 mirMAP -0.23221665156072 0.000114925705972819 NA NA NA hsa-miR-582-5p FBN1 1.08286181406653 0.00149040450161757 -0.23631467770875 0.397554472911853 miRNATAP -0.120420388886036 0.00174047584162371 NA NA NA hsa-miR-590-3p FBN1 0.83851360565783 0.00129224433453587 -0.23631467770875 0.397554472911853 miRanda;mirMAP -0.197055151440876 0.000825816314362061 NA NA NA hsa-miR-92a-3p FBN1 -0.136362762339122 0.493412263619364 -0.23631467770875 0.397554472911853 mirMAP -0.314795140390716 1.01666873524527e-06 NA NA NA hsa-miR-30d-5p FBN2 -0.920901858717441 3.50898334321668e-05 0.296903938977473 0.517403389190351 miRNAWalker2_validate -0.483740877946814 2.27491627903009e-07 NA NA NA hsa-miR-375 FBN2 0.615547997686534 0.149199273675144 0.296903938977473 0.517403389190351 miRanda -0.269525232924705 3.30482592758914e-08 NA NA NA hsa-miR-429 FBN2 2.3794516574089 1.72813419703734e-13 0.296903938977473 0.517403389190351 PITA;miRanda -0.192091286765783 0.00536257956760094 NA NA NA hsa-miR-103a-3p FERMT2 0.538497806383155 1.88134691850591e-05 -1.54180889001218 9.12884009580181e-21 MirTarget -0.20785858044656 0.00107713229606415 NA NA NA hsa-miR-107 FERMT2 0.658676029898313 5.11480446318819e-07 -1.54180889001218 9.12884009580181e-21 MirTarget;miRanda;miRNATAP -0.232297728796759 0.000124337389475214 NA NA NA hsa-miR-15a-5p FERMT2 1.62575353599172 1.55312121019827e-19 -1.54180889001218 9.12884009580181e-21 MirTarget;miRNATAP -0.237037140551474 1.73852199264401e-08 NA NA NA hsa-miR-200b-3p FERMT2 1.55157578247391 4.83790020897188e-09 -1.54180889001218 9.12884009580181e-21 TargetScan -0.258806017378026 6.00823092489701e-20 23483548;24064224;26334393 Here we report that Kindlin 2 markedly downregulates the expression of miR-200 family by inducing CpG island hypermethylation; Our data indicate that Kindlin 2 plays a novel role in epigenetic repression of miR-200 family a mechanism that promotes breast cancer invasion;miR 200b suppresses invasiveness and modulates the cytoskeletal and adhesive machinery in esophageal squamous cell carcinoma cells via targeting Kindlin 2; Quantitative mass spectrometry identified 57 putative miR-200b targets including Kindlin-2 previously implicated in the regulation of tumor invasiveness and actin cytoskeleton in other cell types; Enforced expression of miR-200b mimic in ESCC cells led to a decrease of Kindlin-2 expression whereas transfection of miR-200b inhibitor induced Kindlin-2 expression; Furthermore transfection of miR-200b mimic or knockdown of Kindlin-2 in ESCC cells decreased cell protrusion and focal adhesion FA formation reduced cell spreading and invasiveness/migration; Enforced expression of Kindlin-2 largely abrogated the inhibitory effects of miR-200b on ESCC cell invasiveness; The tumor suppressor effects of miR-200b may be due to its suppression of Kindlin-2 a novel target of miR-200b that modulates actin cytoskeleton FA formation and the migratory/invasiveness properties of ESCC;We revealed that miR-200b suppresses the integrin β1-AKT pathway via targeting Kindlin-2 to mitigate ESCC cell invasiveness ;; breast cancer;esophageal cancer;esophageal cancer hsa-miR-21-5p FERMT2 4.38165933891779 1.52536633902505e-92 -1.54180889001218 9.12884009580181e-21 miRNAWalker2_validate -0.254299675987181 2.52118740060562e-18 NA NA NA hsa-miR-29a-3p FERMT2 0.101650412194573 0.573201097011668 -1.54180889001218 9.12884009580181e-21 MirTarget;miRNATAP -0.123156482416697 0.00546542063792881 NA NA NA hsa-miR-29b-3p FERMT2 3.10527711861309 3.01242507282711e-32 -1.54180889001218 9.12884009580181e-21 MirTarget;miRNATAP -0.250049780440395 2.16484609958195e-20 NA NA NA hsa-miR-29c-3p FERMT2 1.32354490728858 1.84279305179762e-07 -1.54180889001218 9.12884009580181e-21 MirTarget;miRNATAP -0.113359088445077 0.000232934878936085 NA NA NA hsa-miR-30b-5p FERMT2 0.358144314839612 0.138026229059594 -1.54180889001218 9.12884009580181e-21 miRNAWalker2_validate -0.118959936100432 0.00029139113391204 NA NA NA hsa-miR-429 FERMT2 2.3794516574089 1.72813419703734e-13 -1.54180889001218 9.12884009580181e-21 miRanda;miRNATAP -0.235892198878965 2.02655032358642e-21 NA NA NA hsa-miR-454-3p FERMT2 1.49453641052169 4.46235742871434e-09 -1.54180889001218 9.12884009580181e-21 miRNATAP -0.187208573058964 2.61454177384417e-07 NA NA NA hsa-miR-590-3p FERMT2 0.83851360565783 0.00129224433453587 -1.54180889001218 9.12884009580181e-21 MirTarget;miRanda;mirMAP;miRNATAP -0.1258721648054 0.000535883074787359 NA NA NA hsa-miR-590-5p FERMT2 2.07441240363458 4.95240551694843e-14 -1.54180889001218 9.12884009580181e-21 miRanda -0.180564416263671 1.59708248559716e-07 NA NA NA hsa-miR-7-1-3p FERMT2 2.61364240402652 1.98959237815786e-32 -1.54180889001218 9.12884009580181e-21 mirMAP -0.270732060037487 3.72679098179737e-15 NA NA NA hsa-miR-142-3p FGF2 3.98476449801341 1.56256182021111e-35 -2.54526710952658 2.81433930536102e-18 miRanda -0.108425653539561 0.00717069701654876 NA NA NA hsa-miR-15a-5p FGF2 1.62575353599172 1.55312121019827e-19 -2.54526710952658 2.81433930536102e-18 MirTarget;miRNATAP -0.36038112870066 1.28425682158144e-06 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-1-3p FGF2 1.50034693398929 6.63958242991125e-10 -2.54526710952658 2.81433930536102e-18 mirMAP -0.257821575620002 0.000236815470978822 NA NA NA hsa-miR-181b-5p FGF2 0.668793269169928 0.000239998092406404 -2.54526710952658 2.81433930536102e-18 mirMAP -0.262170032088161 0.000626951093969658 NA NA NA hsa-miR-186-5p FGF2 0.852175445703945 6.88885738584309e-10 -2.54526710952658 2.81433930536102e-18 miRNAWalker2_validate;mirMAP -0.312620722879404 0.00189105104228049 NA NA NA hsa-miR-19b-1-5p FGF2 1.71217036351784 3.28561659177495e-12 -2.54526710952658 2.81433930536102e-18 mirMAP -0.32669324350081 2.87433739267694e-07 NA NA NA hsa-miR-200b-3p FGF2 1.55157578247391 4.83790020897188e-09 -2.54526710952658 2.81433930536102e-18 mirMAP -0.237329951619637 4.11083003299206e-06 NA NA NA hsa-miR-200c-3p FGF2 0.380533388300368 0.0842181838538353 -2.54526710952658 2.81433930536102e-18 mirMAP -0.303839594432928 1.47159143745806e-06 NA NA NA hsa-miR-20a-3p FGF2 2.51803599558247 4.92479325298629e-13 -2.54526710952658 2.81433930536102e-18 mirMAP -0.234318235832673 2.96971224443726e-06 NA NA NA hsa-miR-21-3p FGF2 2.54206008030157 1.11598785398763e-30 -2.54526710952658 2.81433930536102e-18 mirMAP -0.372000947223037 1.77917903992197e-10 NA NA NA hsa-miR-21-5p FGF2 4.38165933891779 1.52536633902505e-92 -2.54526710952658 2.81433930536102e-18 mirMAP -0.439558209079983 1.20994163416464e-17 NA NA NA hsa-miR-29a-5p FGF2 1.89519956688438 1.03453349363915e-11 -2.54526710952658 2.81433930536102e-18 mirMAP -0.365049356850144 2.5272073429353e-10 NA NA NA hsa-miR-32-5p FGF2 0.876853679269853 6.04859399018691e-05 -2.54526710952658 2.81433930536102e-18 miRNAWalker2_validate -0.179124683112376 0.00965081572899845 NA NA NA hsa-miR-335-3p FGF2 1.51116383169018 6.88553098788624e-13 -2.54526710952658 2.81433930536102e-18 mirMAP -0.374424532101383 5.108451362917e-09 NA NA NA hsa-miR-429 FGF2 2.3794516574089 1.72813419703734e-13 -2.54526710952658 2.81433930536102e-18 mirMAP -0.274666460864277 1.00411224771278e-09 NA NA NA hsa-miR-450b-5p FGF2 1.69248953402469 1.96052058003353e-07 -2.54526710952658 2.81433930536102e-18 mirMAP -0.165505837504251 0.000468241696245016 NA NA NA hsa-miR-503-5p FGF2 1.97129438815516 2.1704434283035e-09 -2.54526710952658 2.81433930536102e-18 miRNAWalker2_validate -0.205012336037686 7.26622582895517e-07 NA NA NA hsa-miR-589-3p FGF2 1.34253876396688 1.84935927493927e-05 -2.54526710952658 2.81433930536102e-18 mirMAP -0.178139639483111 8.93094177354748e-05 NA NA NA hsa-miR-590-5p FGF2 2.07441240363458 4.95240551694843e-14 -2.54526710952658 2.81433930536102e-18 miRanda;mirMAP -0.34395539570476 1.33985562743507e-08 NA NA NA hsa-miR-93-3p FGF2 1.07631808403007 1.63747525692813e-05 -2.54526710952658 2.81433930536102e-18 mirMAP -0.263196364039628 1.81238194047644e-06 NA NA NA hsa-miR-16-5p FLNA 0.749619098384047 4.11649450706988e-06 -0.924583916672365 4.56435160750428e-05 miRNAWalker2_validate -0.290737189049525 5.84415867008081e-06 NA NA NA hsa-miR-200c-3p FLNA 0.380533388300368 0.0842181838538353 -0.924583916672365 4.56435160750428e-05 miRNAWalker2_validate -0.368304922971275 2.39863918444007e-15 NA NA NA hsa-miR-20a-5p FLNA 2.64649625616975 5.1469418982085e-27 -0.924583916672365 4.56435160750428e-05 miRNAWalker2_validate -0.22239157206061 2.48581666303275e-08 NA NA NA hsa-miR-324-5p FLNA 1.06955541886548 5.39722006604758e-05 -0.924583916672365 4.56435160750428e-05 miRNAWalker2_validate -0.199810957862419 3.17589781396671e-07 NA NA NA hsa-miR-7-5p FLNA 0.343825848926135 0.435063427976906 -0.924583916672365 4.56435160750428e-05 miRNAWalker2_validate -0.118496023454617 6.5588409173022e-05 NA NA NA hsa-miR-92a-3p FLNA -0.136362762339122 0.493412263619364 -0.924583916672365 4.56435160750428e-05 miRNAWalker2_validate -0.140320017317704 0.00832845787321449 NA NA NA hsa-miR-92b-3p FLNA 0.0478787637665503 0.831716894621477 -0.924583916672365 4.56435160750428e-05 miRNAWalker2_validate -0.136897577313915 0.00349430142338408 NA NA NA hsa-miR-1266-5p FMOD -0.289721391624349 0.281500764553995 -0.723828194660036 0.00334071758874437 MirTarget -0.120476374933585 0.00451154603126231 NA NA NA hsa-miR-21-5p FMOD 4.38165933891779 1.52536633902505e-92 -0.723828194660036 0.00334071758874437 miRNAWalker2_validate;miRTarBase -0.207098743431613 1.47850882979566e-06 19906824;23445447 Gain-of miR-21 function in MSMC and LSMC reduced TGF-beta-induced expression of fibromodulin and TGF-beta-induced factor P < 0.05 and moderately altered the rate of cell growth and caspase-3/7 activity in these cells;Our method exhibits ultrahigh sensitivity toward miR-21 with detection limits of 10 fM at 37 °C and 1 aM at 4 °C which corresponds to nine strands of miR-21 in a 15 μL sample and it is capable of distinguishing among miRNA family members ; sarcoma;breast cancer hsa-miR-429 FMOD 2.3794516574089 1.72813419703734e-13 -0.723828194660036 0.00334071758874437 miRNATAP -0.161472444734465 1.2849317740372e-05 NA NA NA hsa-miR-501-5p FMOD 0.411357595674671 0.10435288464149 -0.723828194660036 0.00334071758874437 MirTarget -0.12563168315713 0.00529888386021151 NA NA NA hsa-miR-590-5p FMOD 2.07441240363458 4.95240551694843e-14 -0.723828194660036 0.00334071758874437 miRanda -0.271056639632964 4.13045682742783e-08 NA NA NA hsa-miR-7-1-3p FMOD 2.61364240402652 1.98959237815786e-32 -0.723828194660036 0.00334071758874437 mirMAP -0.150966990718011 0.00299291994243305 NA NA NA hsa-let-7g-5p FN1 0.0837630831079359 0.583083118232597 -0.566807120885738 0.0430749263359056 miRTarBase -0.230921745913925 0.00707072028935924 NA NA NA hsa-miR-16-1-3p FN1 1.50034693398929 6.63958242991125e-10 -0.566807120885738 0.0430749263359056 mirMAP -0.214581262852692 0.000944439200242472 NA NA NA hsa-miR-200b-3p FN1 1.55157578247391 4.83790020897188e-09 -0.566807120885738 0.0430749263359056 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.403184695081414 2.89880355787601e-18 24391862 In contrast mesenchymal markers fibronectin and vimentin were significantly downregulated by miR-200 b prostate cancer hsa-miR-200c-3p FN1 0.380533388300368 0.0842181838538353 -0.566807120885738 0.0430749263359056 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.472021950323672 1.11184411677362e-16 NA NA NA hsa-miR-26b-5p FN1 0.72362441215247 4.7794659748036e-05 -0.566807120885738 0.0430749263359056 miRNAWalker2_validate -0.36304072958237 4.39342083602747e-07 NA NA NA hsa-miR-429 FN1 2.3794516574089 1.72813419703734e-13 -0.566807120885738 0.0430749263359056 MirTarget;PITA;miRanda;miRNATAP -0.310801283540026 4.05201869726347e-14 NA NA NA hsa-miR-96-5p FN1 3.0381097138467 4.40362891630201e-24 -0.566807120885738 0.0430749263359056 MirTarget;TargetScan -0.218740148864903 3.00161127592485e-06 NA NA NA hsa-miR-181b-5p FSTL1 0.668793269169928 0.000239998092406404 -0.57289333705952 0.00809654529783014 mirMAP -0.165748579946289 0.00250291310199019 NA NA NA hsa-miR-200b-3p FSTL1 1.55157578247391 4.83790020897188e-09 -0.57289333705952 0.00809654529783014 MirTarget;TargetScan -0.246545566809393 1.13777218145439e-11 NA NA NA hsa-miR-200c-3p FSTL1 0.380533388300368 0.0842181838538353 -0.57289333705952 0.00809654529783014 MirTarget -0.354826471811973 8.42901614876551e-16 NA NA NA hsa-miR-203a-3p FSTL1 1.06866854356847 0.00389979689199624 -0.57289333705952 0.00809654529783014 MirTarget -0.107121927902053 6.10469980330992e-05 NA NA NA hsa-miR-20a-3p FSTL1 2.51803599558247 4.92479325298629e-13 -0.57289333705952 0.00809654529783014 mirMAP -0.125371682378448 0.000496452673588975 NA NA NA hsa-miR-26b-5p FSTL1 0.72362441215247 4.7794659748036e-05 -0.57289333705952 0.00809654529783014 miRNAWalker2_validate -0.195079005850114 0.000489051599854706 NA NA NA hsa-miR-29a-5p FSTL1 1.89519956688438 1.03453349363915e-11 -0.57289333705952 0.00809654529783014 mirMAP -0.238912726732598 7.65437921662743e-09 NA NA NA hsa-miR-335-3p FSTL1 1.51116383169018 6.88553098788624e-13 -0.57289333705952 0.00809654529783014 mirMAP -0.2940064206714 1.11823089652975e-10 NA NA NA hsa-miR-362-5p FSTL1 0.658947634569393 0.0243306847205756 -0.57289333705952 0.00809654529783014 mirMAP -0.199621024160633 7.14559955441444e-09 NA NA NA hsa-miR-429 FSTL1 2.3794516574089 1.72813419703734e-13 -0.57289333705952 0.00809654529783014 MirTarget;PITA;miRanda -0.19735059757205 7.8909586677054e-10 NA NA NA hsa-miR-576-5p FSTL1 1.02693643167056 1.14846964470173e-06 -0.57289333705952 0.00809654529783014 mirMAP -0.154695051919802 0.000963724175796561 NA NA NA hsa-miR-7-1-3p FSTL1 2.61364240402652 1.98959237815786e-32 -0.57289333705952 0.00809654529783014 MirTarget -0.197414269974229 8.30986378188763e-06 NA NA NA hsa-miR-20a-3p FSTL3 2.51803599558247 4.92479325298629e-13 -1.40359581501048 4.47668763051587e-07 mirMAP -0.153880412200252 0.00100513501815907 NA NA NA hsa-miR-362-3p FSTL3 0.194097672030785 0.52808475179225 -1.40359581501048 4.47668763051587e-07 MirTarget;miRanda -0.14200222409004 0.00715059939268163 NA NA NA hsa-miR-375 FSTL3 0.615547997686534 0.149199273675144 -1.40359581501048 4.47668763051587e-07 miRNAWalker2_validate -0.156217599224909 1.94420033480195e-07 NA NA NA hsa-miR-100-5p FZD8 0.423440403609931 0.104072937074013 -0.671875080608357 0.00760811728424741 MirTarget -0.15045328970468 0.000737292478688576 NA NA NA hsa-miR-148b-3p GADD45A 0.483970528590224 0.0026495409465901 0.295807344757299 0.218383996212033 MirTarget -0.340126647931105 6.86475415101894e-07 NA NA NA hsa-miR-203a-3p GADD45A 1.06866854356847 0.00389979689199624 0.295807344757299 0.218383996212033 MirTarget -0.110751485098685 0.000186426373565797 NA NA NA hsa-miR-375 GADD45A 0.615547997686534 0.149199273675144 0.295807344757299 0.218383996212033 miRanda -0.117305912118485 4.96620623755307e-06 NA NA NA hsa-miR-324-3p GADD45B -0.0774700133118458 0.689226297032231 -1.592999067635 1.71286942854757e-12 MirTarget;miRNATAP -0.153520773002313 0.00557801960543285 NA NA NA hsa-miR-590-3p GADD45B 0.83851360565783 0.00129224433453587 -1.592999067635 1.71286942854757e-12 miRanda -0.128384670833959 0.0087523414105501 NA NA NA hsa-miR-183-5p GAS1 2.39247234736657 3.92444525331999e-21 -1.47012916066268 6.09417415253255e-06 miRNAWalker2_validate -0.286296442725298 4.05625552348618e-07 NA NA NA hsa-miR-186-5p GAS1 0.852175445703945 6.88885738584309e-10 -1.47012916066268 6.09417415253255e-06 mirMAP -0.544568282998412 4.5039189200008e-07 NA NA NA hsa-miR-33a-5p GAS1 2.80127809675219 5.09053890529424e-12 -1.47012916066268 6.09417415253255e-06 miRNATAP -0.133697477844646 0.00299614217565635 NA NA NA hsa-miR-34a-5p GAS1 1.40588612517769 8.60097477768592e-12 -1.47012916066268 6.09417415253255e-06 miRNAWalker2_validate;miRNATAP -0.21757662255334 0.00250537619714484 24220341 MiR 34a targets GAS1 to promote cell proliferation and inhibit apoptosis in papillary thyroid carcinoma via PI3K/Akt/Bad pathway; Both miR-34a and GAS1 are frequently down-regulated in various tumors; However it has been reported that while GAS1 is down-regulated in papillary thyroid carcinoma PTC miR-34a is up-regulated in this specific type of cancer although their potential roles in PTC tumorigenesis have not been examined to date; A computational search revealed that miR-34a putatively binds to the 3'-UTR of GAS1 gene; In the present study we confirmed previous findings that miR-34a is up-regulated and GAS1 down-regulated in PTC tissues; Further studies indicated that GAS1 is directly targeted by miR-34a; Silencing of GAS1 had similar growth-promoting effects as overexpression of miR-34a; Taken together our results demonstrate that miR-34a regulates GAS1 expression to promote proliferation and suppress apoptosis in PTC cells via PI3K/Akt/Bad pathway tumorigenesis thyroid cancer hsa-miR-361-5p GEM 0.21454431962475 0.0800957579368424 0.00846512850303682 0.977827878764591 miRanda -0.423738341115213 0.000266944550300711 NA NA NA hsa-miR-142-3p GJA1 3.98476449801341 1.56256182021111e-35 -1.74013156983702 5.3750450391306e-09 miRanda -0.15286949688257 0.000139997248682854 NA NA NA hsa-miR-148b-5p GJA1 1.39335695292409 2.13220380550073e-07 -1.74013156983702 5.3750450391306e-09 MirTarget -0.202839847451357 0.000997270465604938 NA NA NA hsa-miR-17-5p GJA1 2.07078488653279 2.77403038572568e-19 -1.74013156983702 5.3750450391306e-09 TargetScan -0.310875975092788 6.81043730134053e-08 NA NA NA hsa-miR-185-5p GJA1 1.14291034858482 2.95777119743491e-13 -1.74013156983702 5.3750450391306e-09 MirTarget -0.367801281316232 2.48188575514541e-05 NA NA NA hsa-miR-186-5p GJA1 0.852175445703945 6.88885738584309e-10 -1.74013156983702 5.3750450391306e-09 MirTarget;miRNATAP -0.490381494166834 8.90586524883059e-07 NA NA NA hsa-miR-19a-3p GJA1 2.11776595911517 7.07663078397156e-10 -1.74013156983702 5.3750450391306e-09 MirTarget;miRNATAP -0.215123533262242 5.58453037209324e-06 NA NA NA hsa-miR-19b-3p GJA1 2.10868505662119 5.40846613768389e-17 -1.74013156983702 5.3750450391306e-09 MirTarget;miRNATAP -0.271988647657183 1.23856193318245e-06 NA NA NA hsa-miR-301a-3p GJA1 2.70198002906399 1.56420889710984e-14 -1.74013156983702 5.3750450391306e-09 MirTarget;miRNATAP -0.168249668425783 0.000418796369290371 NA NA NA hsa-miR-30b-5p GJA1 0.358144314839612 0.138026229059594 -1.74013156983702 5.3750450391306e-09 MirTarget;mirMAP -0.179307572814923 0.00196470143711104 NA NA NA hsa-miR-30c-5p GJA1 -0.327319105755825 0.123595832152687 -1.74013156983702 5.3750450391306e-09 MirTarget;mirMAP;miRNATAP -0.243619089460109 0.000212019647348543 NA NA NA hsa-miR-30e-5p GJA1 1.60414100786743 3.78951090573667e-19 -1.74013156983702 5.3750450391306e-09 MirTarget -0.403712807101959 5.74944451901778e-08 NA NA NA hsa-miR-429 GJA1 2.3794516574089 1.72813419703734e-13 -1.74013156983702 5.3750450391306e-09 miRanda;miRNATAP -0.212970073251721 2.58161268216707e-06 NA NA NA hsa-miR-454-3p GJA1 1.49453641052169 4.46235742871434e-09 -1.74013156983702 5.3750450391306e-09 MirTarget;miRNATAP -0.282471912844711 1.1032528294986e-05 NA NA NA hsa-miR-576-5p GJA1 1.02693643167056 1.14846964470173e-06 -1.74013156983702 5.3750450391306e-09 PITA;mirMAP -0.269287001949747 3.79076456516085e-05 NA NA NA hsa-miR-664a-3p GJA1 0.443077463053857 0.0214248925850984 -1.74013156983702 5.3750450391306e-09 MirTarget -0.263748373756044 0.000281013239287648 NA NA NA hsa-miR-7-1-3p GJA1 2.61364240402652 1.98959237815786e-32 -1.74013156983702 5.3750450391306e-09 mirMAP -0.39898227767506 7.26209855607367e-11 NA NA NA hsa-miR-107 GLIPR1 0.658676029898313 5.11480446318819e-07 -0.679120429755334 0.00145362514099095 miRanda -0.353492598713177 2.38095475321961e-06 NA NA NA hsa-miR-148b-5p GLIPR1 1.39335695292409 2.13220380550073e-07 -0.679120429755334 0.00145362514099095 mirMAP -0.239432905670442 2.63656259574453e-08 NA NA NA hsa-miR-19a-3p GLIPR1 2.11776595911517 7.07663078397156e-10 -0.679120429755334 0.00145362514099095 mirMAP -0.219951777857707 2.68834611721673e-11 NA NA NA hsa-miR-19b-3p GLIPR1 2.10868505662119 5.40846613768389e-17 -0.679120429755334 0.00145362514099095 mirMAP -0.268488558234135 6.50612119098436e-12 NA NA NA hsa-miR-20a-3p GLIPR1 2.51803599558247 4.92479325298629e-13 -0.679120429755334 0.00145362514099095 mirMAP -0.192738557037849 4.41917595878826e-08 NA NA NA hsa-miR-26b-3p GLIPR1 1.37388760789373 8.32526977075803e-09 -0.679120429755334 0.00145362514099095 mirMAP -0.139048688584072 0.000631085823089855 NA NA NA hsa-miR-29a-5p GLIPR1 1.89519956688438 1.03453349363915e-11 -0.679120429755334 0.00145362514099095 mirMAP -0.118058168830701 0.00434976804224224 NA NA NA hsa-miR-30d-3p GLIPR1 0.00396376345349925 0.986457040013182 -0.679120429755334 0.00145362514099095 mirMAP -0.222352518950502 2.40736103548579e-06 NA NA NA hsa-miR-335-3p GLIPR1 1.51116383169018 6.88553098788624e-13 -0.679120429755334 0.00145362514099095 mirMAP -0.255574208918517 1.61782831601072e-08 NA NA NA hsa-miR-877-5p GLIPR1 -0.370234513208225 0.20670834111988 -0.679120429755334 0.00145362514099095 MirTarget -0.205114388859922 6.61298516218859e-10 NA NA NA hsa-miR-326 GPC1 -0.992397386750901 0.00335173765975096 0.0276623536793652 0.914466763585196 mirMAP -0.13237430832754 0.000138955056135939 NA NA NA hsa-miR-330-5p GPC1 0.168520831101569 0.336433937906706 0.0276623536793652 0.914466763585196 mirMAP -0.216596983491774 0.00145862460510607 NA NA NA hsa-miR-361-3p GPC1 0.0988926195529967 0.549128728500555 0.0276623536793652 0.914466763585196 mirMAP -0.203795956216434 0.00493361977627822 NA NA NA hsa-miR-29a-3p GPX7 0.101650412194573 0.573201097011668 0.244559030333979 0.310648540322441 MirTarget;miRNATAP -0.24379797430498 7.87804032110097e-05 NA NA NA hsa-miR-29b-3p GPX7 3.10527711861309 3.01242507282711e-32 0.244559030333979 0.310648540322441 MirTarget;miRNATAP -0.140170307229259 0.000358852880966256 NA NA NA hsa-let-7b-3p GREM1 -1.81889978084306 6.9913416210266e-19 3.94409708674604 1.04286982403149e-13 mirMAP -0.322994378052871 0.00635006732353874 NA NA NA hsa-miR-107 GREM1 0.658676029898313 5.11480446318819e-07 3.94409708674604 1.04286982403149e-13 miRanda -0.526464149432076 0.00625469350915543 NA NA NA hsa-miR-139-5p GREM1 -2.26625553116965 7.22375119369519e-16 3.94409708674604 1.04286982403149e-13 miRanda -0.515667421788755 1.49416829465565e-09 NA NA NA hsa-miR-181a-5p GREM1 -0.375429731222937 0.0562142867129802 3.94409708674604 1.04286982403149e-13 MirTarget -0.631158865645944 7.1122138778467e-07 NA NA NA hsa-miR-200b-3p GREM1 1.55157578247391 4.83790020897188e-09 3.94409708674604 1.04286982403149e-13 MirTarget -0.414835422766939 7.69350323438129e-06 NA NA NA hsa-miR-200c-3p GREM1 0.380533388300368 0.0842181838538353 3.94409708674604 1.04286982403149e-13 MirTarget -0.534306330100048 2.53101026291176e-06 NA NA NA hsa-miR-218-5p GREM1 -0.281408491748349 0.259553612322657 3.94409708674604 1.04286982403149e-13 MirTarget -0.433821949544403 2.55979041675039e-05 NA NA NA hsa-miR-30a-3p GREM1 -2.54042202792785 2.9111625410859e-18 3.94409708674604 1.04286982403149e-13 MirTarget -0.717230087761527 2.66598650042062e-19 NA NA NA hsa-miR-30d-3p GREM1 0.00396376345349925 0.986457040013182 3.94409708674604 1.04286982403149e-13 MirTarget -0.976050704669394 8.62765252550408e-17 NA NA NA hsa-miR-30e-3p GREM1 -0.104420043859122 0.526240453209293 3.94409708674604 1.04286982403149e-13 MirTarget -0.691386144692153 6.32226428337779e-06 NA NA NA hsa-miR-3614-5p GREM1 -1.19394699210224 2.53933783780868e-05 3.94409708674604 1.04286982403149e-13 MirTarget -0.394871913613419 6.54663538579128e-06 NA NA NA hsa-miR-362-3p GREM1 0.194097672030785 0.52808475179225 3.94409708674604 1.04286982403149e-13 miRanda -0.294992102417097 0.00393228712274054 NA NA NA hsa-miR-664a-3p GREM1 0.443077463053857 0.0214248925850984 3.94409708674604 1.04286982403149e-13 mirMAP -0.686675997846635 1.18000783524834e-07 NA NA NA hsa-miR-16-5p HTRA1 0.749619098384047 4.11649450706988e-06 -0.310202864896358 0.156178595808374 miRNAWalker2_validate -0.293413401185039 1.70870336733449e-06 NA NA NA hsa-miR-628-5p HTRA1 1.06173574237323 4.67541261016756e-06 -0.310202864896358 0.156178595808374 miRNATAP -0.179449829093897 0.000497424417856885 NA NA NA hsa-miR-19b-3p ID2 2.10868505662119 5.40846613768389e-17 -1.25480152265325 4.20094211960508e-09 MirTarget;miRNATAP -0.112548618093552 0.00543501898035558 NA NA NA hsa-miR-27a-3p ID2 0.433402568013802 0.00737164631768323 -1.25480152265325 4.20094211960508e-09 MirTarget;miRNATAP -0.281027438531934 5.49573953021193e-06 NA NA NA hsa-miR-3065-5p IGFBP3 0.653308707552535 0.0999497219778851 1.34688121148136 3.19621778611777e-05 MirTarget -0.202153450837598 7.15356608364694e-07 NA NA NA hsa-miR-375 IGFBP3 0.615547997686534 0.149199273675144 1.34688121148136 3.19621778611777e-05 miRNAWalker2_validate -0.106212126293924 0.00251113742917914 NA NA NA hsa-miR-330-5p IGFBP4 0.168520831101569 0.336433937906706 -0.646649142953743 0.000684301766069676 MirTarget;miRanda -0.160356778746714 0.00152489328014258 NA NA NA hsa-miR-7-5p IGFBP4 0.343825848926135 0.435063427976906 -0.646649142953743 0.000684301766069676 miRNAWalker2_validate -0.171594109997952 2.06285247289029e-12 NA NA NA hsa-miR-130b-3p IL15 1.83046548750752 5.04753914574694e-13 -0.73920589631764 0.00191051132670785 MirTarget -0.163871207841701 0.000235173367078808 NA NA NA hsa-miR-148b-3p IL15 0.483970528590224 0.0026495409465901 -0.73920589631764 0.00191051132670785 MirTarget -0.225338962698826 0.00103510937176316 NA NA NA hsa-miR-19b-3p IL15 2.10868505662119 5.40846613768389e-17 -0.73920589631764 0.00191051132670785 MirTarget -0.136221728289389 0.00222141143696732 NA NA NA hsa-miR-324-5p IL15 1.06955541886548 5.39722006604758e-05 -0.73920589631764 0.00191051132670785 miRanda -0.166264169404551 5.24035309374909e-05 NA NA NA hsa-miR-429 IL15 2.3794516574089 1.72813419703734e-13 -0.73920589631764 0.00191051132670785 miRanda -0.214920038624398 1.29407855427688e-09 NA NA NA hsa-miR-361-5p IL6 0.21454431962475 0.0800957579368424 -2.77649282936041 1.75717225104248e-11 miRanda -0.437759355067832 0.00687022648152616 NA NA NA hsa-miR-429 IL6 2.3794516574089 1.72813419703734e-13 -2.77649282936041 1.75717225104248e-11 miRanda -0.430343117737244 4.74829761062858e-12 NA NA NA hsa-miR-126-5p INHBA 0.851637714492907 0.000391373420568359 -0.960452802515093 0.00523856427026304 mirMAP -0.253602664768253 0.000113734265808608 NA NA NA hsa-miR-148b-3p INHBA 0.483970528590224 0.0026495409465901 -0.960452802515093 0.00523856427026304 miRNAWalker2_validate -0.308160387391651 0.00189955546046104 NA NA NA hsa-miR-16-2-3p INHBA 0.503964803530872 0.0263648405197492 -0.960452802515093 0.00523856427026304 mirMAP -0.242182711561304 0.00145716530269804 NA NA NA hsa-miR-181b-5p INHBA 0.668793269169928 0.000239998092406404 -0.960452802515093 0.00523856427026304 mirMAP -0.246985240120347 0.00468864311145724 NA NA NA hsa-miR-200b-3p INHBA 1.55157578247391 4.83790020897188e-09 -0.960452802515093 0.00523856427026304 TargetScan -0.439610756138846 1.9730760916325e-14 NA NA NA hsa-miR-26b-5p INHBA 0.72362441215247 4.7794659748036e-05 -0.960452802515093 0.00523856427026304 mirMAP -0.52240208780136 2.90102298497607e-09 NA NA NA hsa-miR-29a-5p INHBA 1.89519956688438 1.03453349363915e-11 -0.960452802515093 0.00523856427026304 mirMAP -0.290318552339075 1.21228349933423e-05 NA NA NA hsa-miR-3065-5p INHBA 0.653308707552535 0.0999497219778851 -0.960452802515093 0.00523856427026304 mirMAP -0.320101551341064 4.18928071318669e-14 NA NA NA hsa-miR-30a-5p INHBA -0.924084264430689 0.000762030454634728 -0.960452802515093 0.00523856427026304 mirMAP -0.292040562687037 3.1540059302911e-07 NA NA NA hsa-miR-30b-5p INHBA 0.358144314839612 0.138026229059594 -0.960452802515093 0.00523856427026304 mirMAP -0.568404951364124 3.51455047382172e-19 NA NA NA hsa-miR-30c-5p INHBA -0.327319105755825 0.123595832152687 -0.960452802515093 0.00523856427026304 mirMAP -0.644937531897466 4.52606564789057e-19 NA NA NA hsa-miR-30d-5p INHBA -0.920901858717441 3.50898334321668e-05 -0.960452802515093 0.00523856427026304 mirMAP -0.489697123943759 1.87072730406886e-12 NA NA NA hsa-miR-30e-5p INHBA 1.60414100786743 3.78951090573667e-19 -0.960452802515093 0.00523856427026304 mirMAP -0.467397598333916 3.300336741594e-08 NA NA NA hsa-miR-335-3p INHBA 1.51116383169018 6.88553098788624e-13 -0.960452802515093 0.00523856427026304 mirMAP -0.290642954137469 7.81045980109123e-05 NA NA NA hsa-miR-374a-5p INHBA -0.197027254874826 0.298080902192861 -0.960452802515093 0.00523856427026304 mirMAP -0.347700859494226 0.000231059659002029 NA NA NA hsa-miR-664a-3p INHBA 0.443077463053857 0.0214248925850984 -0.960452802515093 0.00523856427026304 mirMAP -0.505040516692441 5.82436010522648e-10 NA NA NA hsa-miR-107 ITGA2 0.658676029898313 5.11480446318819e-07 0.819741688063703 0.0236624943026744 MirTarget;miRanda;miRNATAP -0.502644654398121 8.06486079324987e-05 NA NA NA hsa-miR-15b-5p ITGA2 -1.25935038177398 1.83460220856901e-12 0.819741688063703 0.0236624943026744 MirTarget;miRNATAP -0.259522539937534 0.00472053640609525 NA NA NA hsa-miR-16-5p ITGA2 0.749619098384047 4.11649450706988e-06 0.819741688063703 0.0236624943026744 miRNAWalker2_validate;MirTarget;miRNATAP -0.332696009737313 0.00116943184349703 NA NA NA hsa-miR-181c-5p ITGA2 0.529875814537156 0.0125885822998008 0.819741688063703 0.0236624943026744 MirTarget -0.240742904253973 0.00225071857367623 NA NA NA hsa-miR-18a-5p ITGA2 1.37435209536521 9.2173853686829e-06 0.819741688063703 0.0236624943026744 MirTarget -0.31380698282467 4.36049857987287e-08 NA NA NA hsa-miR-19a-3p ITGA2 2.11776595911517 7.07663078397156e-10 0.819741688063703 0.0236624943026744 MirTarget -0.24851476927225 1.1825389761636e-05 NA NA NA hsa-miR-19b-3p ITGA2 2.10868505662119 5.40846613768389e-17 0.819741688063703 0.0236624943026744 MirTarget -0.182640436739443 0.00698279331787996 NA NA NA hsa-miR-200c-3p ITGA2 0.380533388300368 0.0842181838538353 0.819741688063703 0.0236624943026744 mirMAP -0.294353925147486 0.000102858547602016 NA NA NA hsa-miR-26b-5p ITGA2 0.72362441215247 4.7794659748036e-05 0.819741688063703 0.0236624943026744 mirMAP -0.320920069895586 0.000615534045551923 NA NA NA hsa-miR-301a-3p ITGA2 2.70198002906399 1.56420889710984e-14 0.819741688063703 0.0236624943026744 mirMAP -0.153279304256606 0.0074017678161524 NA NA NA hsa-miR-30b-5p ITGA2 0.358144314839612 0.138026229059594 0.819741688063703 0.0236624943026744 mirMAP -0.210045070780396 0.00244968994579558 NA NA NA hsa-miR-324-5p ITGA2 1.06955541886548 5.39722006604758e-05 0.819741688063703 0.0236624943026744 miRanda -0.278448235530963 7.85723061021125e-06 NA NA NA hsa-miR-326 ITGA2 -0.992397386750901 0.00335173765975096 0.819741688063703 0.0236624943026744 PITA -0.171387643372051 0.000481235762466123 NA NA NA hsa-miR-335-5p ITGA2 -0.466533891325811 0.0676987038122831 0.819741688063703 0.0236624943026744 miRNAWalker2_validate -0.291383602328256 6.63115253286623e-05 NA NA NA hsa-miR-424-5p ITGA2 1.26485330287919 6.1498991028257e-06 0.819741688063703 0.0236624943026744 MirTarget;miRNATAP -0.205074133694928 0.000518652085598699 NA NA NA hsa-miR-454-3p ITGA2 1.49453641052169 4.46235742871434e-09 0.819741688063703 0.0236624943026744 mirMAP -0.313493615139346 4.68543025043173e-05 NA NA NA hsa-miR-590-3p ITGA2 0.83851360565783 0.00129224433453587 0.819741688063703 0.0236624943026744 MirTarget;miRanda;mirMAP -0.199501454948866 0.00940455912787266 NA NA NA hsa-miR-107 ITGA5 0.658676029898313 5.11480446318819e-07 -1.01121491098415 8.84227998350758e-06 PITA;miRanda -0.376426978987928 2.81600962880671e-06 NA NA NA hsa-miR-148a-3p ITGA5 2.30885799126944 1.95226081368985e-21 -1.01121491098415 8.84227998350758e-06 miRNATAP -0.190743856582124 3.98731911985598e-06 NA NA NA hsa-miR-148b-3p ITGA5 0.483970528590224 0.0026495409465901 -1.01121491098415 8.84227998350758e-06 miRNAWalker2_validate -0.243410593466733 0.000219706777932876 27328731 Notably transendothelial migration in vitro and extravasation in vivo impaired by singly alternating miR-214 or miR-148b could be overridden by overexpression of ITGA5 or ALCAM in the same tumor cells melanoma hsa-miR-183-5p ITGA5 2.39247234736657 3.92444525331999e-21 -1.01121491098415 8.84227998350758e-06 miRNAWalker2_validate -0.259399847110325 3.43042872637588e-11 NA NA NA hsa-miR-26a-5p ITGA5 -0.126411409001078 0.440028840408711 -1.01121491098415 8.84227998350758e-06 miRNATAP -0.204698760741648 0.00168812743238086 25537511 Furthermore we provide experimental evidence to confirm that ITGA5 is a bona fide target of miR-26a liver cancer hsa-miR-26b-5p ITGA5 0.72362441215247 4.7794659748036e-05 -1.01121491098415 8.84227998350758e-06 miRNATAP -0.188305584857056 0.00150247485518784 NA NA NA hsa-miR-27b-3p ITGA5 0.236438984240408 0.12263510345883 -1.01121491098415 8.84227998350758e-06 miRNATAP -0.229293190778418 0.00100496421391008 NA NA NA hsa-miR-28-5p ITGA5 1.19639196514745 4.59365801666536e-18 -1.01121491098415 8.84227998350758e-06 PITA;miRanda -0.238760737410615 0.00137547168780412 NA NA NA hsa-miR-3065-3p ITGA5 0.381740717819351 0.30795546546997 -1.01121491098415 8.84227998350758e-06 miRNATAP -0.148579744891363 1.02005735906916e-07 NA NA NA hsa-miR-30c-5p ITGA5 -0.327319105755825 0.123595832152687 -1.01121491098415 8.84227998350758e-06 miRNATAP -0.179563357225459 0.000311329951407395 NA NA NA hsa-miR-30d-5p ITGA5 -0.920901858717441 3.50898334321668e-05 -1.01121491098415 8.84227998350758e-06 miRNATAP -0.38902289960491 1.69778694494792e-17 NA NA NA hsa-miR-32-5p ITGA5 0.876853679269853 6.04859399018691e-05 -1.01121491098415 8.84227998350758e-06 miRNATAP -0.168503633823216 0.00125994595302324 NA NA NA hsa-miR-429 ITGA5 2.3794516574089 1.72813419703734e-13 -1.01121491098415 8.84227998350758e-06 miRNATAP -0.351683208392125 4.59050842531831e-27 NA NA NA hsa-miR-98-5p ITGA5 1.170602085804 1.09900501665229e-08 -1.01121491098415 8.84227998350758e-06 miRNAWalker2_validate -0.194633832346188 0.000192318321358743 NA NA NA hsa-miR-186-5p ITGAV 0.852175445703945 6.88885738584309e-10 0.629020501889756 0.00121760194300065 mirMAP -0.250813157407602 0.000100925252185187 NA NA NA hsa-miR-195-3p ITGAV -1.33068822339418 6.65427393047357e-09 0.629020501889756 0.00121760194300065 mirMAP -0.11327382977939 0.00345465236128657 NA NA NA hsa-miR-200a-3p ITGAV 3.14766878548496 1.32850889777422e-21 0.629020501889756 0.00121760194300065 MirTarget -0.127414645651193 1.47196823709712e-06 NA NA NA hsa-miR-25-3p ITGAV 0.361927330834176 0.0163670566170988 0.629020501889756 0.00121760194300065 MirTarget;miRNATAP -0.207835057284429 0.000540572046282237 NA NA NA hsa-miR-32-5p ITGAV 0.876853679269853 6.04859399018691e-05 0.629020501889756 0.00121760194300065 miRNAWalker2_validate;MirTarget;miRNATAP -0.164722332332458 0.000202402491174369 NA NA NA hsa-miR-328-3p ITGAV -0.971820898675371 0.000667255504710486 0.629020501889756 0.00121760194300065 MirTarget -0.127861389315362 4.10469762288386e-05 NA NA NA hsa-miR-429 ITGAV 2.3794516574089 1.72813419703734e-13 0.629020501889756 0.00121760194300065 miRanda -0.131461107413828 6.57884777390413e-06 NA NA NA hsa-miR-92a-3p ITGAV -0.136362762339122 0.493412263619364 0.629020501889756 0.00121760194300065 MirTarget;miRNATAP -0.273385861734189 9.60968012252871e-10 NA NA NA hsa-miR-92b-3p ITGAV 0.0478787637665503 0.831716894621477 0.629020501889756 0.00121760194300065 MirTarget;miRNATAP -0.144437810146408 0.000299309968103135 NA NA NA hsa-miR-140-3p ITGB1 -1.11373309124537 8.35257079443689e-14 -0.0945630286148287 0.525842753551564 PITA -0.152201848271678 0.000723446298763032 NA NA NA hsa-miR-146b-5p ITGB1 1.0922867893808 5.63754607494775e-06 -0.0945630286148287 0.525842753551564 miRanda -0.157715286196658 1.51730634456574e-08 NA NA NA hsa-miR-186-5p ITGB1 0.852175445703945 6.88885738584309e-10 -0.0945630286148287 0.525842753551564 miRNAWalker2_validate -0.201339915376033 4.08520833488966e-05 NA NA NA hsa-miR-195-3p ITGB1 -1.33068822339418 6.65427393047357e-09 -0.0945630286148287 0.525842753551564 mirMAP -0.115798048220866 8.14803984710778e-05 NA NA NA hsa-miR-29a-3p ITGB1 0.101650412194573 0.573201097011668 -0.0945630286148287 0.525842753551564 MirTarget;miRNATAP -0.109878624221877 0.00404808868232385 26903137 hTERT mediates gastric cancer metastasis partially through the indirect targeting of ITGB1 by microRNA 29a; We found that the up-regulation of hTERT in gastric cancer cells could inhibit the expression of miR-29a and enhance the expression of Integrin β1 ITGB1; Our study also found that the restoration of miR-29a suppressed the expression of ITGB1 and inhibited GC cell metastasis both in vitro and in vivo metastasis gastric cancer hsa-miR-29b-3p ITGB1 3.10527711861309 3.01242507282711e-32 -0.0945630286148287 0.525842753551564 MirTarget;miRNATAP -0.116549490422703 1.30157044170051e-06 NA NA NA hsa-miR-29c-3p ITGB1 1.32354490728858 1.84279305179762e-07 -0.0945630286148287 0.525842753551564 MirTarget;miRNATAP -0.105864442600629 6.62006620541073e-05 26766915 MiR 29c inhibits cell growth invasion and migration of pancreatic cancer by targeting ITGB1; Further analysis revealed that ITGB1 is one of the functional target genes of miR-29c and knockdown of ITGB1 inhibited the proliferation migration and invasion of PC cells which was similar to the effects of overexpression of miR-29c pancreatic cancer hsa-miR-375 ITGB1 0.615547997686534 0.149199273675144 -0.0945630286148287 0.525842753551564 miRNAWalker2_validate -0.10471437250037 2.54613318887339e-11 NA NA NA hsa-miR-429 ITGB1 2.3794516574089 1.72813419703734e-13 -0.0945630286148287 0.525842753551564 miRanda -0.142131431355487 9.65693465390098e-11 NA NA NA hsa-let-7d-5p ITGB3 -0.618145137285851 6.06067642715858e-05 0.0458202617452499 0.901111456910611 MirTarget -0.357227641354438 0.00120516547131415 NA NA NA hsa-miR-185-5p ITGB3 1.14291034858482 2.95777119743491e-13 0.0458202617452499 0.901111456910611 MirTarget -0.352714390889775 0.000910586329741436 NA NA NA hsa-miR-186-5p ITGB3 0.852175445703945 6.88885738584309e-10 0.0458202617452499 0.901111456910611 mirMAP -0.569008403398576 2.74458397428635e-06 NA NA NA hsa-miR-30b-5p ITGB3 0.358144314839612 0.138026229059594 0.0458202617452499 0.901111456910611 mirMAP -0.234134873831798 0.000867560552242133 20498642 Enforced constitutive expression of mir-30 in BT-ICs inhibits their self-renewal capacity by reducing Ubc9 and induces apoptosis through silencing ITGB3 breast cancer hsa-miR-30c-5p ITGB3 -0.327319105755825 0.123595832152687 0.0458202617452499 0.901111456910611 miRNAWalker2_validate;mirMAP;miRNATAP -0.229754484199109 0.00413681088320415 NA NA NA hsa-miR-30d-5p ITGB3 -0.920901858717441 3.50898334321668e-05 0.0458202617452499 0.901111456910611 miRNATAP -0.2370999896332 0.00176139579739907 NA NA NA hsa-miR-320b ITGB3 0.226640952564488 0.378818692487242 0.0458202617452499 0.901111456910611 miRanda -0.202928798542316 0.00210098967988018 NA NA NA hsa-miR-338-3p ITGB3 0.726843067232002 0.0506251324215494 0.0458202617452499 0.901111456910611 miRanda -0.144755795263914 0.00145730847965422 27431198 Furthermore we also identified a metastasis related protein integrin β3 ITGB3 as a novel target gene of miR-338 metastasis lung cancer hsa-miR-425-5p ITGB3 1.21659524959201 8.01126418494715e-09 0.0458202617452499 0.901111456910611 MirTarget -0.336225303608678 2.09149227158485e-05 NA NA NA hsa-miR-429 ITGB3 2.3794516574089 1.72813419703734e-13 0.0458202617452499 0.901111456910611 miRanda -0.208336534572015 0.000162930117373071 NA NA NA hsa-miR-590-5p ITGB3 2.07441240363458 4.95240551694843e-14 0.0458202617452499 0.901111456910611 miRanda -0.305496818831574 3.74015409256109e-05 NA NA NA hsa-miR-335-5p ITGB5 -0.466533891325811 0.0676987038122831 0.0914403769390919 0.565322367903286 miRNAWalker2_validate -0.186953458336436 3.26260715161371e-09 NA NA NA hsa-miR-141-3p JUN 3.36993755486106 5.42939251147195e-32 -0.999359590084937 1.13112331580714e-06 miRNATAP -0.117569383056825 0.000149604234896854 NA NA NA hsa-miR-148a-5p JUN 1.45633512586855 1.81792463521257e-08 -0.999359590084937 1.13112331580714e-06 miRNATAP -0.104130733311401 0.00423603987630484 NA NA NA hsa-miR-542-3p LAMA2 1.62226640768239 2.6427102465476e-10 -1.33151497975485 1.22646297955714e-06 miRanda -0.138780904391796 0.00451509326464665 NA NA NA hsa-miR-590-3p LAMA2 0.83851360565783 0.00129224433453587 -1.33151497975485 1.22646297955714e-06 miRanda -0.360214388029535 4.44606430582782e-10 NA NA NA hsa-miR-17-5p LAMA3 2.07078488653279 2.77403038572568e-19 -2.10170523801193 1.03016004869603e-05 TargetScan -0.250971115908008 0.00663400056402506 NA NA NA hsa-miR-146b-5p LAMC1 1.0922867893808 5.63754607494775e-06 -0.110787086889143 0.490508859847474 miRanda -0.157155518419593 1.82576679330076e-07 NA NA NA hsa-miR-15a-5p LAMC1 1.62575353599172 1.55312121019827e-19 -0.110787086889143 0.490508859847474 MirTarget -0.190138810277497 1.30631412770968e-06 NA NA NA hsa-miR-200b-3p LAMC1 1.55157578247391 4.83790020897188e-09 -0.110787086889143 0.490508859847474 MirTarget;TargetScan -0.105419600597403 0.000112500689688591 NA NA NA hsa-miR-29a-3p LAMC1 0.101650412194573 0.573201097011668 -0.110787086889143 0.490508859847474 MirTarget;miRNATAP -0.132455277091454 0.00129663761462845 26052614 The identification of laminin gamma 1 LAMC1 and myeloid cell leukemia 1 MCL1 as direct targets of miR-22 and miR-29a respectively suggested a tumor-suppressive role of these miRNAs prostate cancer hsa-miR-29b-3p LAMC1 3.10527711861309 3.01242507282711e-32 -0.110787086889143 0.490508859847474 MirTarget;miRNATAP -0.144783511342865 2.16330017197383e-08 NA NA NA hsa-miR-429 LAMC1 2.3794516574089 1.72813419703734e-13 -0.110787086889143 0.490508859847474 MirTarget;PITA;miRanda;miRNATAP -0.105179895117571 1.14146615944986e-05 NA NA NA hsa-miR-642a-5p LAMC1 0.788077674970441 0.0303202946051994 -0.110787086889143 0.490508859847474 MirTarget -0.101886169635082 7.79484143348306e-07 NA NA NA hsa-miR-148b-3p LAMC2 0.483970528590224 0.0026495409465901 -0.106160755851652 0.773201990515692 miRNAWalker2_validate -0.531031363320226 4.18007243804894e-07 NA NA NA hsa-miR-375 LAMC2 0.615547997686534 0.149199273675144 -0.106160755851652 0.773201990515692 miRanda -0.352593273467605 1.92048173866575e-20 NA NA NA hsa-miR-660-5p LAMC2 2.04875198906126 1.08269480928897e-17 -0.106160755851652 0.773201990515692 MirTarget -0.268942936723928 0.000120478466718749 NA NA NA hsa-miR-107 LOX 0.658676029898313 5.11480446318819e-07 -0.158614436503135 0.562786626933452 miRanda -0.390827078107161 4.77915001532295e-05 NA NA NA hsa-miR-181b-5p LOX 0.668793269169928 0.000239998092406404 -0.158614436503135 0.562786626933452 miRNATAP -0.211725618333981 0.00223045655155026 NA NA NA hsa-miR-186-5p LOX 0.852175445703945 6.88885738584309e-10 -0.158614436503135 0.562786626933452 mirMAP -0.371063420865964 4.06595312024997e-05 NA NA NA hsa-miR-200b-3p LOX 1.55157578247391 4.83790020897188e-09 -0.158614436503135 0.562786626933452 TargetScan -0.373584677972968 1.76326608099088e-16 NA NA NA hsa-miR-26b-5p LOX 0.72362441215247 4.7794659748036e-05 -0.158614436503135 0.562786626933452 mirMAP -0.234403105352528 0.000916527955039228 NA NA NA hsa-miR-29a-3p LOX 0.101650412194573 0.573201097011668 -0.158614436503135 0.562786626933452 miRNATAP -0.214531144385885 0.00230686613131841 25153510 Second the direct interaction between one of the upregulated mRNA target the LOX gene which is an EMT key player and a downregulated miRNA the miR-29a was experimentally validated by a luciferase assay in HEK cell thyroid cancer hsa-miR-29b-3p LOX 3.10527711861309 3.01242507282711e-32 -0.158614436503135 0.562786626933452 miRNATAP -0.237916478787971 7.55361870445673e-08 NA NA NA hsa-miR-29c-3p LOX 1.32354490728858 1.84279305179762e-07 -0.158614436503135 0.562786626933452 miRNATAP -0.133929068186554 0.00639224282929262 NA NA NA hsa-miR-3065-3p LOX 0.381740717819351 0.30795546546997 -0.158614436503135 0.562786626933452 miRNATAP -0.196289955147528 3.25852110060543e-09 NA NA NA hsa-miR-3065-5p LOX 0.653308707552535 0.0999497219778851 -0.158614436503135 0.562786626933452 mirMAP -0.212076252584218 4.11115153984601e-10 NA NA NA hsa-miR-30a-5p LOX -0.924084264430689 0.000762030454634728 -0.158614436503135 0.562786626933452 miRNATAP -0.123228947984578 0.00708546699691001 NA NA NA hsa-miR-30c-5p LOX -0.327319105755825 0.123595832152687 -0.158614436503135 0.562786626933452 miRNATAP -0.382814674882765 5.78967556039973e-11 NA NA NA hsa-miR-30d-5p LOX -0.920901858717441 3.50898334321668e-05 -0.158614436503135 0.562786626933452 miRNATAP -0.419008890905318 2.31742621147385e-14 NA NA NA hsa-miR-335-3p LOX 1.51116383169018 6.88553098788624e-13 -0.158614436503135 0.562786626933452 mirMAP -0.245003655502639 2.64660711225959e-05 NA NA NA hsa-miR-335-5p LOX -0.466533891325811 0.0676987038122831 -0.158614436503135 0.562786626933452 miRNAWalker2_validate -0.180180746915321 0.0011097681052944 NA NA NA hsa-miR-374a-5p LOX -0.197027254874826 0.298080902192861 -0.158614436503135 0.562786626933452 mirMAP -0.209945350044995 0.00520430658173915 NA NA NA hsa-miR-429 LOX 2.3794516574089 1.72813419703734e-13 -0.158614436503135 0.562786626933452 miRanda;miRNATAP -0.297901988357829 1.23028580856356e-13 NA NA NA hsa-miR-664a-3p LOX 0.443077463053857 0.0214248925850984 -0.158614436503135 0.562786626933452 mirMAP -0.304661307849108 3.01929744463838e-06 NA NA NA hsa-miR-148b-3p LOXL1 0.483970528590224 0.0026495409465901 0.738197427450119 0.00177491009383074 miRNAWalker2_validate -0.282979747727046 3.05957199913726e-05 NA NA NA hsa-miR-335-5p LOXL1 -0.466533891325811 0.0676987038122831 0.738197427450119 0.00177491009383074 miRNAWalker2_validate -0.291041387000885 6.67857604235465e-10 NA NA NA hsa-miR-93-5p LOXL1 1.50844106515467 1.83836866996875e-12 0.738197427450119 0.00177491009383074 miRNAWalker2_validate -0.17461233039192 0.000454402132774072 NA NA NA hsa-miR-338-3p LOXL2 0.726843067232002 0.0506251324215494 1.02453455700776 0.00102666255501673 miRanda -0.182067664779427 2.18427937540856e-06 NA NA NA hsa-miR-107 LRP1 0.658676029898313 5.11480446318819e-07 -1.14901996340017 1.93886353465499e-08 PITA;miRNATAP -0.325281532792345 7.77104158298874e-06 NA NA NA hsa-miR-200b-3p LRP1 1.55157578247391 4.83790020897188e-09 -1.14901996340017 1.93886353465499e-08 TargetScan -0.128153797226702 0.000294266633764682 NA NA NA hsa-miR-335-5p LRP1 -0.466533891325811 0.0676987038122831 -1.14901996340017 1.93886353465499e-08 miRNAWalker2_validate -0.186583199880371 7.60612486958535e-06 NA NA NA hsa-miR-429 LRP1 2.3794516574089 1.72813419703734e-13 -1.14901996340017 1.93886353465499e-08 PITA;miRanda;miRNATAP -0.160851479380438 1.97328703439633e-07 NA NA NA hsa-miR-590-3p LRP1 0.83851360565783 0.00129224433453587 -1.14901996340017 1.93886353465499e-08 PITA;miRanda;miRNATAP -0.253035169162912 5.10670081192165e-09 NA NA NA hsa-miR-590-5p LRP1 2.07441240363458 4.95240551694843e-14 -1.14901996340017 1.93886353465499e-08 miRanda -0.184926231821991 9.1812160951733e-06 NA NA NA hsa-miR-107 LRRC15 0.658676029898313 5.11480446318819e-07 1.33391293332535 0.00489523037601343 PITA -0.91589617964673 3.29720339749004e-08 NA NA NA hsa-miR-15b-3p LRRC15 0.804736041893915 0.000400279611457186 1.33391293332535 0.00489523037601343 mirMAP -0.329703929078711 0.00112977061523661 NA NA NA hsa-miR-17-3p LRRC15 1.36706429551147 4.60388403547821e-13 1.33391293332535 0.00489523037601343 mirMAP -0.543220155311208 1.42812843641567e-06 NA NA NA hsa-miR-200a-3p LRRC15 3.14766878548496 1.32850889777422e-21 1.33391293332535 0.00489523037601343 mirMAP -0.268630915924727 3.31537157642358e-05 NA NA NA hsa-miR-2110 LRRC15 -1.92124860612475 1.1464887721828e-12 1.33391293332535 0.00489523037601343 mirMAP -0.283814848253604 0.000368765824266223 NA NA NA hsa-miR-3065-5p LRRC15 0.653308707552535 0.0999497219778851 1.33391293332535 0.00489523037601343 mirMAP -0.287196193426593 1.36323821673925e-06 NA NA NA hsa-miR-30a-5p LRRC15 -0.924084264430689 0.000762030454634728 1.33391293332535 0.00489523037601343 mirMAP -0.557397629295442 7.16815741543027e-13 NA NA NA hsa-miR-30b-5p LRRC15 0.358144314839612 0.138026229059594 1.33391293332535 0.00489523037601343 mirMAP -0.456552524177186 4.00999838337815e-07 NA NA NA hsa-miR-30c-5p LRRC15 -0.327319105755825 0.123595832152687 1.33391293332535 0.00489523037601343 mirMAP -0.530677764431395 2.21209006591127e-07 NA NA NA hsa-miR-30d-5p LRRC15 -0.920901858717441 3.50898334321668e-05 1.33391293332535 0.00489523037601343 mirMAP -0.665809832937776 3.86029018849822e-12 NA NA NA hsa-miR-3614-5p LRRC15 -1.19394699210224 2.53933783780868e-05 1.33391293332535 0.00489523037601343 mirMAP -0.374754453291748 8.70749287762102e-07 NA NA NA hsa-miR-374a-5p LRRC15 -0.197027254874826 0.298080902192861 1.33391293332535 0.00489523037601343 mirMAP -0.406881086907661 0.00181106156567367 NA NA NA hsa-miR-429 LRRC15 2.3794516574089 1.72813419703734e-13 1.33391293332535 0.00489523037601343 miRNATAP -0.261439803657872 0.000249469632762113 NA NA NA hsa-let-7f-1-3p LUM -0.0921261289038979 0.693970843315065 -0.416181063810662 0.108681714481146 mirMAP -0.172967368099584 0.00674312684934296 NA NA NA hsa-miR-16-2-3p LUM 0.503964803530872 0.0263648405197492 -0.416181063810662 0.108681714481146 mirMAP -0.364562022465906 9.01578406138988e-11 NA NA NA hsa-miR-590-3p LUM 0.83851360565783 0.00129224433453587 -0.416181063810662 0.108681714481146 miRanda;mirMAP -0.155188494912638 0.00468102051902726 NA NA NA hsa-miR-590-5p LUM 2.07441240363458 4.95240551694843e-14 -0.416181063810662 0.108681714481146 MirTarget;PITA;miRanda -0.267581325599161 2.54241806420207e-07 NA NA NA hsa-miR-7-1-3p LUM 2.61364240402652 1.98959237815786e-32 -0.416181063810662 0.108681714481146 mirMAP -0.252083047902354 1.91385646473101e-06 NA NA NA hsa-miR-421 MAGEE1 0.170525317701774 0.535277026680289 -0.423822108683533 0.0611751424806939 miRanda -0.127309615642208 0.00201961831211331 NA NA NA hsa-miR-590-3p MAGEE1 0.83851360565783 0.00129224433453587 -0.423822108683533 0.0611751424806939 miRanda -0.277275044098036 4.29662095466998e-09 NA NA NA hsa-miR-671-5p MAGEE1 2.24156654191798 2.10433241567652e-14 -0.423822108683533 0.0611751424806939 MirTarget -0.156732511728364 0.000140933434171231 NA NA NA hsa-miR-21-5p MATN2 4.38165933891779 1.52536633902505e-92 -1.53279876540753 1.03020756689882e-05 miRNATAP -0.421755026183514 2.37249481837976e-12 NA NA NA hsa-miR-335-3p MATN2 1.51116383169018 6.88553098788624e-13 -1.53279876540753 1.03020756689882e-05 mirMAP -0.337070968810089 6.23219419957106e-06 NA NA NA hsa-miR-590-3p MATN2 0.83851360565783 0.00129224433453587 -1.53279876540753 1.03020756689882e-05 miRanda;mirMAP;miRNATAP -0.382627742932823 1.88924988916941e-07 NA NA NA hsa-miR-590-5p MATN2 2.07441240363458 4.95240551694843e-14 -1.53279876540753 1.03020756689882e-05 PITA;miRanda;miRNATAP -0.390005420575341 2.556770693649e-08 NA NA NA hsa-miR-130b-3p MATN3 1.83046548750752 5.04753914574694e-13 -2.07481001455436 6.15299803085225e-10 MirTarget -0.327464969737598 2.29210900130341e-07 NA NA NA hsa-miR-148a-3p MATN3 2.30885799126944 1.95226081368985e-21 -2.07481001455436 6.15299803085225e-10 MirTarget -0.195047298309557 0.00164668172438804 NA NA NA hsa-miR-148b-3p MATN3 0.483970528590224 0.0026495409465901 -2.07481001455436 6.15299803085225e-10 miRNAWalker2_validate;MirTarget -0.368154075454342 0.000174333072527111 NA NA NA hsa-miR-19a-3p MATN3 2.11776595911517 7.07663078397156e-10 -2.07481001455436 6.15299803085225e-10 MirTarget -0.359129375598088 9.21075699821926e-12 NA NA NA hsa-miR-19b-3p MATN3 2.10868505662119 5.40846613768389e-17 -2.07481001455436 6.15299803085225e-10 MirTarget -0.440465772023052 1.6137456640487e-12 NA NA NA hsa-miR-429 MATN3 2.3794516574089 1.72813419703734e-13 -2.07481001455436 6.15299803085225e-10 miRanda -0.166810678374158 0.00116770696540363 NA NA NA hsa-miR-590-3p MATN3 0.83851360565783 0.00129224433453587 -2.07481001455436 6.15299803085225e-10 miRanda;mirMAP -0.219224330552264 0.00241812255284464 NA NA NA hsa-let-7b-5p MCM7 -1.62016148171663 1.56547487335694e-15 1.03612798352766 1.71713234333092e-08 miRNAWalker2_validate -0.330473925018445 9.85177088438153e-17 NA NA NA hsa-miR-144-5p MEST -1.3899604395726 0.000237414824562107 1.08451435645614 5.26747634326276e-08 MirTarget -0.10344210588543 2.05617550166731e-05 NA NA NA hsa-miR-145-5p MEST -1.34926078156437 2.63526538800669e-07 1.08451435645614 5.26747634326276e-08 miRNAWalker2_validate;MirTarget;miRNATAP -0.232146546342426 1.4830070412712e-11 NA NA NA hsa-miR-155-5p MEST 0.813513839059142 0.000608282725633232 1.08451435645614 5.26747634326276e-08 miRNAWalker2_validate -0.11000832523562 0.00490167871689782 NA NA NA hsa-miR-29a-3p MEST 0.101650412194573 0.573201097011668 1.08451435645614 5.26747634326276e-08 MirTarget;miRNATAP -0.282463595046757 3.8274513586589e-08 NA NA NA hsa-miR-29c-3p MEST 1.32354490728858 1.84279305179762e-07 1.08451435645614 5.26747634326276e-08 MirTarget;miRNATAP -0.199786373011968 2.36906230381378e-08 NA NA NA hsa-miR-3065-3p MEST 0.381740717819351 0.30795546546997 1.08451435645614 5.26747634326276e-08 MirTarget;miRNATAP -0.160452288308124 4.56496065383214e-11 NA NA NA hsa-miR-34b-3p MEST -1.69479533615636 0.00178266322862085 1.08451435645614 5.26747634326276e-08 MirTarget -0.108234377007334 6.10173335434386e-10 NA NA NA hsa-miR-34c-5p MEST -1.00125440032112 0.0724432896090357 1.08451435645614 5.26747634326276e-08 MirTarget;miRanda -0.127652258707448 8.36117458652993e-14 NA NA NA hsa-miR-455-5p MEST 1.36946341828134 5.05118627562807e-08 1.08451435645614 5.26747634326276e-08 miRanda -0.170455214537262 5.11175700938079e-05 NA NA NA hsa-miR-664a-3p MEST 0.443077463053857 0.0214248925850984 1.08451435645614 5.26747634326276e-08 MirTarget -0.309896815444969 7.66643171007363e-11 NA NA NA hsa-miR-126-5p MFAP5 0.851637714492907 0.000391373420568359 -1.11290331271114 0.0382110007219332 mirMAP -0.448616889359597 1.13042381359863e-05 NA NA NA hsa-miR-15a-5p MFAP5 1.62575353599172 1.55312121019827e-19 -1.11290331271114 0.0382110007219332 MirTarget -0.512262605437563 0.00011045861245448 NA NA NA hsa-miR-15b-3p MFAP5 0.804736041893915 0.000400279611457186 -1.11290331271114 0.0382110007219332 MirTarget -0.326358008262542 0.00441476155125033 NA NA NA hsa-miR-16-5p MFAP5 0.749619098384047 4.11649450706988e-06 -1.11290331271114 0.0382110007219332 MirTarget -0.592128917042917 9.27376495763723e-05 NA NA NA hsa-miR-200b-3p MFAP5 1.55157578247391 4.83790020897188e-09 -1.11290331271114 0.0382110007219332 TargetScan -0.532924726360207 4.16937057065421e-09 NA NA NA hsa-miR-200c-3p MFAP5 0.380533388300368 0.0842181838538353 -1.11290331271114 0.0382110007219332 miRNATAP -0.729774311812937 4.2067238964402e-11 NA NA NA hsa-miR-429 MFAP5 2.3794516574089 1.72813419703734e-13 -1.11290331271114 0.0382110007219332 miRanda;miRNATAP -0.37473018561568 3.09765417650809e-06 NA NA NA hsa-miR-326 MMP1 -0.992397386750901 0.00335173765975096 4.30322375851502 7.4915171123606e-12 miRanda -0.272355188213522 0.00178689348646548 NA NA NA hsa-miR-26a-5p MMP14 -0.126411409001078 0.440028840408711 0.853770939661442 0.000211702855196161 miRNATAP -0.236934517399567 0.000310393452321971 NA NA NA hsa-miR-29b-2-5p MMP14 0.345881055247341 0.194842633194187 0.853770939661442 0.000211702855196161 mirMAP -0.145624335642802 0.000267000295950336 NA NA NA hsa-miR-3065-3p MMP14 0.381740717819351 0.30795546546997 0.853770939661442 0.000211702855196161 miRNATAP -0.138939008906734 8.65918649996826e-07 NA NA NA hsa-miR-335-5p MMP14 -0.466533891325811 0.0676987038122831 0.853770939661442 0.000211702855196161 miRNAWalker2_validate -0.253291054437186 4.47022860939599e-08 NA NA NA hsa-miR-374a-5p MMP14 -0.197027254874826 0.298080902192861 0.853770939661442 0.000211702855196161 MirTarget -0.185451201466868 0.00353891986357018 NA NA NA hsa-miR-17-5p MMP2 2.07078488653279 2.77403038572568e-19 -0.238353685048638 0.371129175798068 miRNAWalker2_validate;TargetScan -0.345787611664891 5.03823151056117e-12 NA NA NA hsa-miR-335-5p MMP2 -0.466533891325811 0.0676987038122831 -0.238353685048638 0.371129175798068 miRNAWalker2_validate -0.329919266057948 4.59064521400206e-10 NA NA NA hsa-miR-421 MMP2 0.170525317701774 0.535277026680289 -0.238353685048638 0.371129175798068 miRanda -0.215777410550919 7.65954835516393e-06 NA NA NA hsa-miR-101-3p MSX1 1.38889039459232 1.96522549511542e-09 -1.32761041242429 9.61922053766115e-07 miRNATAP -0.160559822673514 0.00278326226131144 NA NA NA hsa-miR-21-5p MSX1 4.38165933891779 1.52536633902505e-92 -1.32761041242429 9.61922053766115e-07 miRNATAP -0.137818685907996 0.00411890834301053 NA NA NA hsa-miR-139-5p MXRA5 -2.26625553116965 7.22375119369519e-16 0.994195084812002 0.00185891361164045 miRanda -0.209211763629544 3.62869415461983e-05 NA NA NA hsa-miR-144-3p MXRA5 -2.1603497940894 3.64553026877274e-07 0.994195084812002 0.00185891361164045 MirTarget;miRNATAP -0.127681795872346 0.00041668207488236 NA NA NA hsa-miR-30a-5p MXRA5 -0.924084264430689 0.000762030454634728 0.994195084812002 0.00185891361164045 miRNATAP -0.251117852193909 2.34849382350197e-06 NA NA NA hsa-miR-30c-2-3p MXRA5 -3.10905250533941 6.84550165664783e-27 0.994195084812002 0.00185891361164045 MirTarget -0.163174597310294 0.000678541766734998 NA NA NA hsa-miR-30d-5p MXRA5 -0.920901858717441 3.50898334321668e-05 0.994195084812002 0.00185891361164045 miRNATAP -0.555236959265223 3.02094056959404e-18 NA NA NA hsa-miR-335-3p MXRA5 1.51116383169018 6.88553098788624e-13 0.994195084812002 0.00185891361164045 MirTarget -0.27101921628423 7.4098814406926e-05 NA NA NA hsa-miR-330-5p MYL9 0.168520831101569 0.336433937906706 -1.93874043140749 1.06910851726748e-19 MirTarget;miRanda -0.216169065457011 0.000235418541242187 NA NA NA hsa-miR-107 MYLK 0.658676029898313 5.11480446318819e-07 -1.63193711258573 1.44155005364888e-11 miRanda -0.544854627144271 2.0295988476841e-10 NA NA NA hsa-miR-142-3p MYLK 3.98476449801341 1.56256182021111e-35 -1.63193711258573 1.44155005364888e-11 PITA;miRanda -0.104170042669482 0.00148861058715313 NA NA NA hsa-miR-15a-5p MYLK 1.62575353599172 1.55312121019827e-19 -1.63193711258573 1.44155005364888e-11 MirTarget;miRNATAP -0.464059593581389 5.73853532984706e-15 NA NA NA hsa-miR-15b-5p MYLK -1.25935038177398 1.83460220856901e-12 -1.63193711258573 1.44155005364888e-11 MirTarget;miRNATAP -0.16767185316299 0.0073716118243401 NA NA NA hsa-miR-16-2-3p MYLK 0.503964803530872 0.0263648405197492 -1.63193711258573 1.44155005364888e-11 mirMAP -0.332326782980381 5.99632587868441e-10 NA NA NA hsa-miR-16-5p MYLK 0.749619098384047 4.11649450706988e-06 -1.63193711258573 1.44155005364888e-11 MirTarget;miRNATAP -0.448780246980521 6.09371614549853e-11 NA NA NA hsa-miR-186-5p MYLK 0.852175445703945 6.88885738584309e-10 -1.63193711258573 1.44155005364888e-11 mirMAP -0.565906822613118 1.73557792720404e-12 NA NA NA hsa-miR-193b-3p MYLK 1.10444771306846 0.000822888533401377 -1.63193711258573 1.44155005364888e-11 miRNAWalker2_validate -0.119166935070949 0.000495707370233346 NA NA NA hsa-miR-200b-3p MYLK 1.55157578247391 4.83790020897188e-09 -1.63193711258573 1.44155005364888e-11 TargetScan -0.199778794391928 1.89469828576053e-06 NA NA NA hsa-miR-335-3p MYLK 1.51116383169018 6.88553098788624e-13 -1.63193711258573 1.44155005364888e-11 mirMAP -0.383010095813906 1.15853053717969e-13 NA NA NA hsa-miR-362-5p MYLK 0.658947634569393 0.0243306847205756 -1.63193711258573 1.44155005364888e-11 TargetScan;miRNATAP -0.230016952183572 4.89771923158465e-09 NA NA NA hsa-miR-424-5p MYLK 1.26485330287919 6.1498991028257e-06 -1.63193711258573 1.44155005364888e-11 MirTarget;miRNATAP -0.119484343971119 0.00303112334222558 NA NA NA hsa-miR-429 MYLK 2.3794516574089 1.72813419703734e-13 -1.63193711258573 1.44155005364888e-11 PITA;miRanda;miRNATAP -0.231344138647783 2.50019051817547e-10 NA NA NA hsa-miR-501-5p MYLK 0.411357595674671 0.10435288464149 -1.63193711258573 1.44155005364888e-11 MirTarget;PITA;miRNATAP -0.250409411529626 1.7526592858789e-08 NA NA NA hsa-miR-576-5p MYLK 1.02693643167056 1.14846964470173e-06 -1.63193711258573 1.44155005364888e-11 PITA;mirMAP -0.310470866101837 4.01378514120072e-09 NA NA NA hsa-miR-582-5p MYLK 1.08286181406653 0.00149040450161757 -1.63193711258573 1.44155005364888e-11 PITA;mirMAP -0.157528803291297 3.24776362456179e-06 NA NA NA hsa-miR-589-3p MYLK 1.34253876396688 1.84935927493927e-05 -1.63193711258573 1.44155005364888e-11 mirMAP -0.140911374492869 0.000142550998340425 NA NA NA hsa-miR-590-3p MYLK 0.83851360565783 0.00129224433453587 -1.63193711258573 1.44155005364888e-11 MirTarget;miRanda;mirMAP -0.274979329518061 1.0544310300127e-07 NA NA NA hsa-miR-590-5p MYLK 2.07441240363458 4.95240551694843e-14 -1.63193711258573 1.44155005364888e-11 miRanda -0.359816924289509 1.54193538484206e-13 NA NA NA hsa-miR-9-5p MYLK 4.99250901331516 2.59132733422801e-19 -1.63193711258573 1.44155005364888e-11 miRNAWalker2_validate -0.100344172078578 2.35758738740161e-07 NA NA NA hsa-miR-101-3p NID2 1.38889039459232 1.96522549511542e-09 0.0411417023511316 0.880148808766318 miRNATAP -0.197105309098177 0.000213606215831904 NA NA NA hsa-miR-125a-5p NID2 -1.04824536696301 3.97386082850476e-07 0.0411417023511316 0.880148808766318 miRanda -0.169697424847283 0.00482668452708702 NA NA NA hsa-miR-30a-5p NID2 -0.924084264430689 0.000762030454634728 0.0411417023511316 0.880148808766318 miRNATAP -0.243595925904382 6.26700812957146e-08 NA NA NA hsa-miR-30c-5p NID2 -0.327319105755825 0.123595832152687 0.0411417023511316 0.880148808766318 miRNATAP -0.338447595324991 7.11075608938728e-09 NA NA NA hsa-miR-30d-5p NID2 -0.920901858717441 3.50898334321668e-05 0.0411417023511316 0.880148808766318 miRNATAP -0.393770484245085 6.96158897954364e-13 NA NA NA hsa-miR-106a-5p NOTCH2 1.3902608059488 6.07931522284525e-05 -0.119481238625473 0.492880718191772 miRNAWalker2_validate -0.111485130608144 1.19721303178239e-05 NA NA NA hsa-miR-15a-5p NOTCH2 1.62575353599172 1.55312121019827e-19 -0.119481238625473 0.492880718191772 MirTarget -0.13657692819362 0.00146588996416673 NA NA NA hsa-miR-16-1-3p NOTCH2 1.50034693398929 6.63958242991125e-10 -0.119481238625473 0.492880718191772 mirMAP -0.107628252574588 0.00757908931225651 NA NA NA hsa-miR-16-5p NOTCH2 0.749619098384047 4.11649450706988e-06 -0.119481238625473 0.492880718191772 miRNAWalker2_validate;MirTarget -0.181494702892157 0.000212192551661016 NA NA NA hsa-miR-17-5p NOTCH2 2.07078488653279 2.77403038572568e-19 -0.119481238625473 0.492880718191772 miRNAWalker2_validate -0.19595507089954 2.60398067047312e-09 NA NA NA hsa-miR-181c-5p NOTCH2 0.529875814537156 0.0125885822998008 -0.119481238625473 0.492880718191772 miRNAWalker2_validate;MirTarget -0.15041563246032 6.34034361439095e-05 26983574;25494473 This is supported by the depletion of CTCF in glioblastoma cells affecting the expression levels of NOTCH2 as a target of miR-181c;Finally investigation of the mechanism defined Notch2 a key molecular of Notch signaling as the functional downstream target of miR-181c; An inverse correlation was found between miR-181c and Notch2 in glioma cells and verified in fresh glioma samples; miR-181c acts as a tumor suppressor that attenuates proliferation invasion and self-renewal capacities by downregulation of Notch2 in glioma cells ; glioblastoma;glioblastoma hsa-miR-181d-5p NOTCH2 1.19058140522592 8.5908558852417e-09 -0.119481238625473 0.492880718191772 MirTarget -0.169702281788348 7.96388240317372e-06 NA NA NA hsa-miR-186-5p NOTCH2 0.852175445703945 6.88885738584309e-10 -0.119481238625473 0.492880718191772 mirMAP -0.200192704438245 0.000504794625435529 NA NA NA hsa-miR-374a-5p NOTCH2 -0.197027254874826 0.298080902192861 -0.119481238625473 0.492880718191772 mirMAP -0.142784810215257 0.00274638560523679 NA NA NA hsa-miR-590-3p NOTCH2 0.83851360565783 0.00129224433453587 -0.119481238625473 0.492880718191772 miRanda -0.116888849132645 0.00145800951050541 NA NA NA hsa-miR-590-5p NOTCH2 2.07441240363458 4.95240551694843e-14 -0.119481238625473 0.492880718191772 miRanda -0.114692507591321 0.00107671597972069 NA NA NA hsa-miR-92a-3p NOTCH2 -0.136362762339122 0.493412263619364 -0.119481238625473 0.492880718191772 miRNAWalker2_validate -0.173028342893204 1.69594370584163e-05 NA NA NA hsa-miR-129-5p NT5E -0.405735314747643 0.341485636033577 0.922015769517585 0.0180088153515731 miRanda -0.115519490329154 0.00640323666458976 NA NA NA hsa-miR-30c-5p NT5E -0.327319105755825 0.123595832152687 0.922015769517585 0.0180088153515731 miRNATAP -0.249284934605155 0.0033342097877802 NA NA NA hsa-miR-590-5p NT5E 2.07441240363458 4.95240551694843e-14 0.922015769517585 0.0180088153515731 miRanda -0.235611144721757 0.00282457257747992 NA NA NA hsa-miR-182-5p NTM 3.21839823004635 5.13049145201115e-39 -1.0616141669806 0.00122271686738417 miRTarBase -0.249530208057082 9.21611485526877e-06 NA NA NA hsa-miR-3065-5p NTM 0.653308707552535 0.0999497219778851 -1.0616141669806 0.00122271686738417 mirMAP;miRNATAP -0.147814261920992 0.000362884616556206 NA NA NA hsa-miR-30c-5p NTM -0.327319105755825 0.123595832152687 -1.0616141669806 0.00122271686738417 miRNATAP -0.193977965116323 0.00686877020707032 NA NA NA hsa-miR-30d-5p NTM -0.920901858717441 3.50898334321668e-05 -1.0616141669806 0.00122271686738417 miRNATAP -0.191229357112928 0.0048745872285862 NA NA NA hsa-miR-339-5p NTM 0.536997313601114 0.0488090394176611 -1.0616141669806 0.00122271686738417 miRanda -0.157236189151724 0.00478073582011749 NA NA NA hsa-miR-429 NTM 2.3794516574089 1.72813419703734e-13 -1.0616141669806 0.00122271686738417 miRanda;miRNATAP -0.189398905624873 0.000128147158670529 NA NA NA hsa-miR-942-5p NTM -0.0372813055050076 0.870631058767894 -1.0616141669806 0.00122271686738417 MirTarget -0.18251650489185 0.00762775358046891 NA NA NA hsa-miR-30d-3p OXTR 0.00396376345349925 0.986457040013182 -0.0676034422894295 0.853648131095526 mirMAP -0.350636254674561 1.42696056988435e-05 NA NA NA hsa-miR-338-3p OXTR 0.726843067232002 0.0506251324215494 -0.0676034422894295 0.853648131095526 miRanda -0.162975166805719 0.000304461097855761 NA NA NA hsa-miR-375 OXTR 0.615547997686534 0.149199273675144 -0.0676034422894295 0.853648131095526 miRanda -0.154847538174764 8.07771426720983e-05 NA NA NA hsa-miR-130b-5p PCOLCE2 1.53645187062942 1.10498816261505e-08 -3.57345831492237 9.50584443402438e-14 MirTarget -0.298666634343437 0.000323936006880362 NA NA NA hsa-miR-182-5p PCOLCE2 3.21839823004635 5.13049145201115e-39 -3.57345831492237 9.50584443402438e-14 miRNAWalker2_validate -0.688030126942935 4.87873371999794e-17 NA NA NA hsa-miR-192-5p PCOLCE2 2.03412119423736 1.6357945826287e-05 -3.57345831492237 9.50584443402438e-14 miRNAWalker2_validate -0.132998362276197 0.00525675273180617 NA NA NA hsa-miR-590-3p PCOLCE2 0.83851360565783 0.00129224433453587 -3.57345831492237 9.50584443402438e-14 MirTarget;miRanda -0.294423927632997 0.00481277083140528 NA NA NA hsa-miR-29b-3p PDGFRB 3.10527711861309 3.01242507282711e-32 -0.472627234019869 0.0195049282675806 miRNATAP -0.101003962314959 0.00225724349565461 NA NA NA hsa-miR-3127-5p PDGFRB 0.382717393698386 0.11535780874721 -0.472627234019869 0.0195049282675806 mirMAP -0.153147342374875 6.32703967379545e-05 NA NA NA hsa-miR-421 PDGFRB 0.170525317701774 0.535277026680289 -0.472627234019869 0.0195049282675806 miRanda -0.182914387101734 5.73372143884839e-07 NA NA NA hsa-miR-326 PDLIM4 -0.992397386750901 0.00335173765975096 0.715281645918727 0.040989548569957 miRanda -0.20758665677277 1.10268362958623e-05 NA NA NA hsa-miR-330-5p PDLIM4 0.168520831101569 0.336433937906706 0.715281645918727 0.040989548569957 miRanda -0.463642774042978 4.63727611828096e-07 NA NA NA hsa-miR-335-5p PDLIM4 -0.466533891325811 0.0676987038122831 0.715281645918727 0.040989548569957 miRNAWalker2_validate -0.322168698643357 4.64023296197993e-06 NA NA NA hsa-miR-139-5p PFN2 -2.26625553116965 7.22375119369519e-16 0.934889331771678 0.00464292278824028 MirTarget;PITA;miRanda -0.268884895478414 2.39784205410504e-07 NA NA NA hsa-miR-150-5p PFN2 -0.702328520623782 0.0215316651134431 0.934889331771678 0.00464292278824028 miRNATAP -0.270343853836715 4.08419959214003e-08 NA NA NA hsa-miR-218-5p PFN2 -0.281408491748349 0.259553612322657 0.934889331771678 0.00464292278824028 miRNATAP -0.259125354913307 3.4612571804287e-05 NA NA NA hsa-miR-3065-5p PFN2 0.653308707552535 0.0999497219778851 0.934889331771678 0.00464292278824028 MirTarget;mirMAP -0.271970489413745 3.13171110616574e-11 NA NA NA hsa-miR-30a-5p PFN2 -0.924084264430689 0.000762030454634728 0.934889331771678 0.00464292278824028 MirTarget;miRNATAP -0.391014509365926 4.79744678769992e-13 NA NA NA hsa-miR-30b-3p PFN2 -1.20976737190106 2.63726511331003e-06 0.934889331771678 0.00464292278824028 miRNATAP -0.286390581234519 8.88039393844873e-07 NA NA NA hsa-miR-30b-5p PFN2 0.358144314839612 0.138026229059594 0.934889331771678 0.00464292278824028 MirTarget -0.268565338789999 2.01001189765416e-05 NA NA NA hsa-miR-30c-5p PFN2 -0.327319105755825 0.123595832152687 0.934889331771678 0.00464292278824028 MirTarget;miRNATAP -0.414006982909418 5.7193417601297e-09 NA NA NA hsa-miR-30d-5p PFN2 -0.920901858717441 3.50898334321668e-05 0.934889331771678 0.00464292278824028 MirTarget;miRNATAP -0.463904446276795 3.7828200319246e-12 NA NA NA hsa-miR-320a PFN2 -0.961144925954715 1.62478794429204e-08 0.934889331771678 0.00464292278824028 miRanda -0.280672244653985 0.00159210173961785 NA NA NA hsa-miR-338-3p PFN2 0.726843067232002 0.0506251324215494 0.934889331771678 0.00464292278824028 miRanda -0.212672791361311 1.53359867882109e-07 NA NA NA hsa-miR-491-5p PFN2 -0.472928614372062 0.0683344127929203 0.934889331771678 0.00464292278824028 miRanda -0.168485087910708 0.0044617788277238 NA NA NA hsa-miR-508-3p PFN2 0.140176864166629 0.79184421367121 0.934889331771678 0.00464292278824028 PITA;miRNATAP -0.170264945054363 4.81785461226542e-09 NA NA NA hsa-miR-204-5p PLAUR -1.01965803752657 0.00767207541525746 0.0779914521270308 0.757112973276917 miRNAWalker2_validate -0.140182209256048 3.78147877699475e-06 NA NA NA hsa-let-7a-5p PLOD1 -1.37014061604018 3.11451492971224e-14 0.656179825554415 3.46222812842451e-06 miRNAWalker2_validate -0.158619969049413 7.10753716358944e-06 NA NA NA hsa-miR-335-5p PLOD1 -0.466533891325811 0.0676987038122831 0.656179825554415 3.46222812842451e-06 MirTarget -0.137215340112956 1.55737642896094e-06 NA NA NA hsa-miR-26a-5p PLOD2 -0.126411409001078 0.440028840408711 1.27626900643861 6.592887294488e-05 MirTarget;miRNATAP -0.468339724882361 2.40086489698333e-07 26983694;27310702 Thus our data showed that two genes promoting metastasis LOXL2 and PLOD2 were epigenetically regulated by tumor-suppressive microRNAs miR-26a and miR-26b providing important insights into the molecular mechanisms of RCC metastasis;The gene encoding procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 PLOD2 a collagen crosslinking enzyme was directly regulated by miR-26a-5p and miR-26b-5p; PLOD2 which is associated with the stiffness of the extracellular matrix was directly regulated by miR-26a-5p and miR-26b-5p and may be a good prognostic marker in patients with BC metastasis; kidney renal cell cancer;bladder cancer hsa-miR-26b-5p PLOD2 0.72362441215247 4.7794659748036e-05 1.27626900643861 6.592887294488e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.268566702124518 0.00125426515742608 26983694;27310702 Thus our data showed that two genes promoting metastasis LOXL2 and PLOD2 were epigenetically regulated by tumor-suppressive microRNAs miR-26a and miR-26b providing important insights into the molecular mechanisms of RCC metastasis;Tumour suppressive miRNA 26a 5p and miR 26b 5p inhibit cell aggressiveness by regulating PLOD2 in bladder cancer; The gene encoding procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 PLOD2 a collagen crosslinking enzyme was directly regulated by miR-26a-5p and miR-26b-5p; PLOD2 which is associated with the stiffness of the extracellular matrix was directly regulated by miR-26a-5p and miR-26b-5p and may be a good prognostic marker in patients with BC metastasis; kidney renal cell cancer;bladder cancer hsa-miR-429 PLOD2 2.3794516574089 1.72813419703734e-13 1.27626900643861 6.592887294488e-05 miRanda -0.214872561807165 8.19434255277859e-06 NA NA NA hsa-miR-103a-3p PMEPA1 0.538497806383155 1.88134691850591e-05 0.304394001071769 0.231381999994033 mirMAP -0.493534132329223 1.09175055471083e-07 NA NA NA hsa-miR-107 PMEPA1 0.658676029898313 5.11480446318819e-07 0.304394001071769 0.231381999994033 mirMAP -0.409424802966311 4.2323519603967e-06 NA NA NA hsa-miR-15a-5p PMEPA1 1.62575353599172 1.55312121019827e-19 0.304394001071769 0.231381999994033 mirMAP -0.187174948163268 0.00288378071949862 NA NA NA hsa-miR-15b-5p PMEPA1 -1.25935038177398 1.83460220856901e-12 0.304394001071769 0.231381999994033 mirMAP -0.338993578196033 9.92167026574321e-08 NA NA NA hsa-miR-16-5p PMEPA1 0.749619098384047 4.11649450706988e-06 0.304394001071769 0.231381999994033 mirMAP -0.372263959023342 1.65982471742852e-07 NA NA NA hsa-miR-19a-3p PMEPA1 2.11776595911517 7.07663078397156e-10 0.304394001071769 0.231381999994033 MirTarget;miRNATAP -0.145817962799708 0.000252785249945291 NA NA NA hsa-miR-19b-3p PMEPA1 2.10868505662119 5.40846613768389e-17 0.304394001071769 0.231381999994033 MirTarget;miRNATAP -0.150276497175794 0.00150092719830777 NA NA NA hsa-miR-301a-3p PMEPA1 2.70198002906399 1.56420889710984e-14 0.304394001071769 0.231381999994033 MirTarget;miRNATAP -0.154259665119586 0.000111056146885256 NA NA NA hsa-miR-32-5p PMEPA1 0.876853679269853 6.04859399018691e-05 0.304394001071769 0.231381999994033 miRNATAP -0.188620438251056 0.00110967682908081 NA NA NA hsa-miR-335-3p PMEPA1 1.51116383169018 6.88553098788624e-13 0.304394001071769 0.231381999994033 MirTarget -0.3395918141301 2.16185588816367e-10 NA NA NA hsa-miR-335-5p PMEPA1 -0.466533891325811 0.0676987038122831 0.304394001071769 0.231381999994033 mirMAP -0.250316394695558 8.86241754887224e-07 NA NA NA hsa-miR-421 PMEPA1 0.170525317701774 0.535277026680289 0.304394001071769 0.231381999994033 miRanda -0.210000412212173 5.02163762750719e-06 NA NA NA hsa-miR-454-3p PMEPA1 1.49453641052169 4.46235742871434e-09 0.304394001071769 0.231381999994033 MirTarget;miRNATAP -0.284165482664163 1.14616510914243e-07 NA NA NA hsa-miR-532-3p PMEPA1 -0.677758187385834 0.0147557885796065 0.304394001071769 0.231381999994033 mirMAP -0.155308407835655 0.000212106996090282 NA NA NA hsa-miR-92a-3p PMEPA1 -0.136362762339122 0.493412263619364 0.304394001071769 0.231381999994033 miRNATAP -0.31944376443193 4.65019038895307e-08 NA NA NA hsa-miR-92b-3p PMEPA1 0.0478787637665503 0.831716894621477 0.304394001071769 0.231381999994033 miRNATAP -0.193864128183271 0.000193408147232791 NA NA NA hsa-miR-26b-5p PMP22 0.72362441215247 4.7794659748036e-05 -1.48687702477309 1.7919332614432e-13 miRNAWalker2_validate -0.159638839490669 0.00291094558569918 NA NA NA hsa-miR-29b-3p PMP22 3.10527711861309 3.01242507282711e-32 -1.48687702477309 1.7919332614432e-13 MirTarget;miRNATAP -0.17441265698953 2.00457323007942e-07 NA NA NA hsa-miR-421 PMP22 0.170525317701774 0.535277026680289 -1.48687702477309 1.7919332614432e-13 PITA;miRanda -0.153688100201232 4.4183542606472e-05 NA NA NA hsa-miR-429 PMP22 2.3794516574089 1.72813419703734e-13 -1.48687702477309 1.7919332614432e-13 PITA;miRanda;miRNATAP -0.240578077187152 2.07286649374139e-15 NA NA NA hsa-miR-450b-5p PMP22 1.69248953402469 1.96052058003353e-07 -1.48687702477309 1.7919332614432e-13 mirMAP -0.110671330095829 0.000620639720595408 NA NA NA hsa-miR-505-3p PMP22 0.239188197517314 0.273992679374017 -1.48687702477309 1.7919332614432e-13 MirTarget;miRNATAP -0.140702940277553 0.00131800727672828 NA NA NA hsa-miR-590-3p PMP22 0.83851360565783 0.00129224433453587 -1.48687702477309 1.7919332614432e-13 miRanda -0.195902320842084 6.94572168808388e-06 NA NA NA hsa-miR-651-5p PMP22 1.67013048675395 1.61458229225137e-07 -1.48687702477309 1.7919332614432e-13 MirTarget -0.198502228116417 5.14178015166364e-08 NA NA NA hsa-miR-9-5p PMP22 4.99250901331516 2.59132733422801e-19 -1.48687702477309 1.7919332614432e-13 MirTarget;miRNATAP -0.110031434620238 8.71630741723915e-12 NA NA NA hsa-miR-139-5p POSTN -2.26625553116965 7.22375119369519e-16 0.95903356950865 0.00281142379920665 miRanda -0.179949436946043 0.00041838689481678 NA NA NA hsa-miR-106a-5p PRRX1 1.3902608059488 6.07931522284525e-05 0.217202793959696 0.392321797274242 MirTarget;miRNATAP -0.146682015087134 8.1496822511745e-05 NA NA NA hsa-miR-106b-5p PRRX1 1.47447672652218 1.32004094930462e-13 0.217202793959696 0.392321797274242 MirTarget;miRNATAP -0.249991788848952 1.14919393622616e-05 26617763 Down regualtion of miR 106b induces epithelial mesenchymal transition but suppresses metastatic colonization by targeting Prrx1 in colorectal cancer; We identified Prrx1 was a direct target of miR-106b through using target prediction algorithms and dual-Luciferase reporter assay; Moreover Moreover we also found TGF-β1 could down-regulate miR-106b and simultaneously miR-106b also influences the expression of TGF-β1 establishing a negative feedback loop to regulate the expression of Prrx1 together colorectal cancer hsa-miR-148b-5p PRRX1 1.39335695292409 2.13220380550073e-07 0.217202793959696 0.392321797274242 MirTarget -0.198634832397285 0.000112253990222892 NA NA NA hsa-miR-16-2-3p PRRX1 0.503964803530872 0.0263648405197492 0.217202793959696 0.392321797274242 MirTarget -0.195710041398989 0.000458820465335916 NA NA NA hsa-miR-17-5p PRRX1 2.07078488653279 2.77403038572568e-19 0.217202793959696 0.392321797274242 MirTarget;TargetScan;miRNATAP -0.257818643233604 8.80355355294543e-08 NA NA NA hsa-miR-186-5p PRRX1 0.852175445703945 6.88885738584309e-10 0.217202793959696 0.392321797274242 mirMAP -0.362891329015332 1.44866798970485e-05 NA NA NA hsa-miR-200b-5p PRRX1 0.5652412449293 0.0273948420835934 0.217202793959696 0.392321797274242 mirMAP -0.205769751046345 5.65723803432194e-06 NA NA NA hsa-miR-20a-5p PRRX1 2.64649625616975 5.1469418982085e-27 0.217202793959696 0.392321797274242 MirTarget;miRNATAP -0.232817977650482 1.56139718617211e-07 NA NA NA hsa-miR-335-3p PRRX1 1.51116383169018 6.88553098788624e-13 0.217202793959696 0.392321797274242 MirTarget;mirMAP -0.335852775309923 3.17853243470014e-10 NA NA NA hsa-miR-338-3p PRRX1 0.726843067232002 0.0506251324215494 0.217202793959696 0.392321797274242 miRanda -0.126568002427574 4.98916310413311e-05 NA NA NA hsa-miR-361-3p PRRX1 0.0988926195529967 0.549128728500555 0.217202793959696 0.392321797274242 PITA -0.211244281605382 0.0031160237570974 NA NA NA hsa-miR-500a-5p PRRX1 0.648155655714409 0.0104657432932038 0.217202793959696 0.392321797274242 mirMAP -0.226133431663813 1.490997839898e-06 NA NA NA hsa-miR-576-5p PRRX1 1.02693643167056 1.14846964470173e-06 0.217202793959696 0.392321797274242 mirMAP -0.144949515818 0.00834914193165132 NA NA NA hsa-miR-664a-3p PRRX1 0.443077463053857 0.0214248925850984 0.217202793959696 0.392321797274242 mirMAP -0.183345230923825 0.00259012808249051 NA NA NA hsa-miR-7-1-3p PRRX1 2.61364240402652 1.98959237815786e-32 0.217202793959696 0.392321797274242 mirMAP -0.148764367887282 0.00433981524137942 NA NA NA hsa-miR-93-5p PRRX1 1.50844106515467 1.83836866996875e-12 0.217202793959696 0.392321797274242 MirTarget;miRNATAP -0.263352498968057 6.53133401297028e-07 NA NA NA hsa-miR-96-5p PRRX1 3.0381097138467 4.40362891630201e-24 0.217202793959696 0.392321797274242 MirTarget;TargetScan -0.138644826809328 0.00113926744396327 NA NA NA hsa-miR-139-5p PTHLH -2.26625553116965 7.22375119369519e-16 1.64338339752708 0.000515907525110145 miRanda -0.384994998340535 2.635027711009e-07 NA NA NA hsa-miR-15b-5p PTHLH -1.25935038177398 1.83460220856901e-12 1.64338339752708 0.000515907525110145 MirTarget -0.466831912643265 0.000100027842005691 NA NA NA hsa-miR-195-5p PTHLH -1.01577502605386 4.80814718341729e-05 1.64338339752708 0.000515907525110145 MirTarget -0.266992551842675 0.00369074835233581 NA NA NA hsa-miR-29a-3p PTHLH 0.101650412194573 0.573201097011668 1.64338339752708 0.000515907525110145 MirTarget -0.368911604941939 0.00257827209678379 NA NA NA hsa-miR-3065-3p PTHLH 0.381740717819351 0.30795546546997 1.64338339752708 0.000515907525110145 MirTarget;miRNATAP -0.49726266864897 1.15528639566863e-18 NA NA NA hsa-miR-21-5p PTX3 4.38165933891779 1.52536633902505e-92 -1.94541129344397 1.44165774534121e-08 miRNAWalker2_validate -0.240799492355718 7.65034803848397e-05 NA NA NA hsa-miR-29b-3p PTX3 3.10527711861309 3.01242507282711e-32 -1.94541129344397 1.44165774534121e-08 MirTarget -0.289000027437934 3.05160045473024e-07 NA NA NA hsa-miR-330-5p PTX3 0.168520831101569 0.336433937906706 -1.94541129344397 1.44165774534121e-08 miRanda -0.252996822739177 0.00618899755991649 NA NA NA hsa-miR-582-5p PTX3 1.08286181406653 0.00149040450161757 -1.94541129344397 1.44165774534121e-08 miRNATAP -0.155974350805392 0.00116738200099995 NA NA NA hsa-miR-7-1-3p PTX3 2.61364240402652 1.98959237815786e-32 -1.94541129344397 1.44165774534121e-08 mirMAP -0.379744730368406 8.62886745257897e-08 NA NA NA hsa-let-7b-5p PVR -1.62016148171663 1.56547487335694e-15 -0.255291644614958 0.0983931929507414 miRNAWalker2_validate -0.112572467468902 0.000906021590541723 NA NA NA hsa-miR-150-5p PVR -0.702328520623782 0.0215316651134431 -0.255291644614958 0.0983931929507414 mirMAP -0.11330628529819 8.38400359538806e-07 NA NA NA hsa-miR-218-5p PVR -0.281408491748349 0.259553612322657 -0.255291644614958 0.0983931929507414 mirMAP -0.133195014515222 4.58926100863538e-06 NA NA NA hsa-miR-664a-3p PVR 0.443077463053857 0.0214248925850984 -0.255291644614958 0.0983931929507414 mirMAP -0.178436717935998 1.17173968807951e-06 NA NA NA hsa-miR-106b-5p QSOX1 1.47447672652218 1.32004094930462e-13 -0.153445755459279 0.434078757841526 mirMAP -0.182347377511559 3.46494319046883e-05 NA NA NA hsa-miR-142-5p QSOX1 1.29672439149353 4.0768822158894e-06 -0.153445755459279 0.434078757841526 mirMAP -0.121777523032033 0.000394376252143466 NA NA NA hsa-miR-185-5p QSOX1 1.14291034858482 2.95777119743491e-13 -0.153445755459279 0.434078757841526 MirTarget -0.206791031708694 0.000248730604300512 NA NA NA hsa-miR-335-3p QSOX1 1.51116383169018 6.88553098788624e-13 -0.153445755459279 0.434078757841526 mirMAP -0.141866973860157 0.000696993088943073 NA NA NA hsa-miR-340-5p QSOX1 -0.668005790839634 0.018612920432186 -0.153445755459279 0.434078757841526 mirMAP -0.10948980946302 0.00282641431885322 NA NA NA hsa-miR-374b-3p QSOX1 -0.157526212601818 0.538677664999491 -0.153445755459279 0.434078757841526 mirMAP -0.13360744684572 0.00180205358135387 NA NA NA hsa-miR-452-5p QSOX1 0.637123950346362 0.0458173998136196 -0.153445755459279 0.434078757841526 mirMAP -0.10625876949151 0.000158742461391084 NA NA NA hsa-miR-590-3p QSOX1 0.83851360565783 0.00129224433453587 -0.153445755459279 0.434078757841526 mirMAP -0.132279280285113 0.00138466107160534 NA NA NA hsa-miR-93-5p QSOX1 1.50844106515467 1.83836866996875e-12 -0.153445755459279 0.434078757841526 mirMAP -0.116122453022721 0.0048595774971834 NA NA NA hsa-miR-103a-3p RGS4 0.538497806383155 1.88134691850591e-05 0.196887922136346 0.564222419675049 MirTarget;miRNATAP -0.637265190592612 3.3550498486599e-07 NA NA NA hsa-miR-107 RGS4 0.658676029898313 5.11480446318819e-07 0.196887922136346 0.564222419675049 MirTarget;miRanda;miRNATAP -0.403325412311451 0.000786266608579389 NA NA NA hsa-miR-26b-5p RGS4 0.72362441215247 4.7794659748036e-05 0.196887922136346 0.564222419675049 MirTarget;miRNATAP -0.250470471960344 0.00454269599633022 NA NA NA hsa-miR-30b-3p RGS4 -1.20976737190106 2.63726511331003e-06 0.196887922136346 0.564222419675049 MirTarget -0.242042988688944 5.90637272677881e-05 NA NA NA hsa-miR-340-5p RGS4 -0.668005790839634 0.018612920432186 0.196887922136346 0.564222419675049 MirTarget;mirMAP -0.196041261987117 0.00214740401898577 NA NA NA hsa-miR-374a-5p RGS4 -0.197027254874826 0.298080902192861 0.196887922136346 0.564222419675049 MirTarget -0.282281956969639 0.00255679978107043 NA NA NA hsa-miR-664a-3p RGS4 0.443077463053857 0.0214248925850984 0.196887922136346 0.564222419675049 mirMAP -0.311217706974256 0.000137492362864975 NA NA NA hsa-miR-146b-5p RHOB 1.0922867893808 5.63754607494775e-06 -0.816440724935267 0.000691602560764595 miRanda -0.24522397548058 6.63148480616772e-08 NA NA NA hsa-miR-183-5p RHOB 2.39247234736657 3.92444525331999e-21 -0.816440724935267 0.000691602560764595 miRNATAP -0.12896626724567 0.00212496890259305 NA NA NA hsa-miR-21-5p RHOB 4.38165933891779 1.52536633902505e-92 -0.816440724935267 0.000691602560764595 miRNAWalker2_validate;miRTarBase;miRNATAP -0.111372159234376 0.00861644941281711 21872591;25861727 miR 21 targets the tumor suppressor RhoB and regulates proliferation invasion and apoptosis in colorectal cancer cells; Here we show that expression of miR-21 in HEK293 and several colorectal cancer cells was found inversely correlated with ras homolog gene family member B RhoB expression; miR-21 expression significantly suppressed RhoB 3' UTR luciferase-reporter activity but the inhibitory effect was lost when the putative target sites were mutated; Exogenous miR-21 over-expression mimicked the effect of RhoB knockdown in promoting proliferation and invasion and inhibiting apoptosis whereas anti-miR-21 or RhoB expression yielded opposite effects in colorectal cancer cells; These results suggest that miR-21 is a regulator of RhoB expression and RhoB could be a useful target in exploring the potential therapeutic benefits of miR-21 mediated tumor cell behaviors in colorectal cancer;Here we demonstrate that intravenously-administered chlorotoxin CTX-coupled targeted stable nucleic acid lipid particle SNALP-formulated anti-miR-21 oligonucleotides accumulate preferentially within brain tumors and promote efficient miR-21 silencing which results in increased mRNA and protein levels of its target RhoB while showing no signs of systemic immunogenicity ; colorectal cancer;glioblastoma hsa-miR-421 RHOB 0.170525317701774 0.535277026680289 -0.816440724935267 0.000691602560764595 miRNAWalker2_validate -0.160591024739743 0.000257230003956395 NA NA NA hsa-miR-590-5p RHOB 2.07441240363458 4.95240551694843e-14 -0.816440724935267 0.000691602560764595 PITA;miRanda;miRNATAP -0.153212119259773 0.00169299755194764 NA NA NA hsa-miR-744-3p RHOB 2.07439104592565 3.30645434602132e-12 -0.816440724935267 0.000691602560764595 MirTarget -0.137439432413413 0.000156401616125218 NA NA NA hsa-miR-744-5p SAT1 -0.490424133130113 0.00934825173175428 -0.177358454406866 0.314517292281545 miRNAWalker2_validate -0.17494909399011 4.56145839046087e-05 NA NA NA hsa-miR-155-5p SCG2 0.813513839059142 0.000608282725633232 0.0696844213905587 0.878545003674585 MirTarget;miRNATAP -0.266691124955995 0.00247870300960666 NA NA NA hsa-miR-452-3p SCG2 0.477736876273128 0.22218404598603 0.0696844213905587 0.878545003674585 MirTarget -0.310757764821509 4.95470089481165e-07 NA NA NA hsa-miR-10b-5p SDC1 -0.0791496820139503 0.826561024018303 0.634163049633123 0.00201592176429863 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.113039100376344 1.49992105297095e-05 22573479 In breast cancer overexpression of the transmembrane heparan sulfate proteoglycan syndecan-1 a predicted target of the oncomiR miR-10b correlates with poor clinical outcome; To investigate the potential functional relationship of miR-10b and syndecan-1 MDA-MB-231 and MCF-7 breast cancer cells were transiently transfected with pre-miR-10b syndecan-1 siRNA or control reagents respectively; miR-10b overexpression induced post-transcriptional downregulation of syndecan-1 as demonstrated by quantitative real-time PCR qPCR flow cytometry and 3'UTR luciferase assays resulting in increased cancer cell migration and matrigel invasiveness; We conclude that syndecan-1 is a novel target of the oncomiR miR-10b cell migration breast cancer hsa-miR-18a-5p SDC1 1.37435209536521 9.2173853686829e-06 0.634163049633123 0.00201592176429863 mirMAP -0.174494864210158 8.2796123150613e-08 NA NA NA hsa-miR-19a-3p SDC1 2.11776595911517 7.07663078397156e-10 0.634163049633123 0.00201592176429863 MirTarget;miRNATAP -0.115348308144592 0.000356693181549488 NA NA NA hsa-miR-19b-1-5p SDC1 1.71217036351784 3.28561659177495e-12 0.634163049633123 0.00201592176429863 MirTarget -0.118891170137861 0.00645663903487873 NA NA NA hsa-miR-130b-3p SDC4 1.83046548750752 5.04753914574694e-13 -0.752957409763706 5.23236535490951e-05 MirTarget -0.185539323816565 8.52177983849146e-08 NA NA NA hsa-miR-142-3p SDC4 3.98476449801341 1.56256182021111e-35 -0.752957409763706 5.23236535490951e-05 miRanda -0.106846485875417 1.56874387439942e-05 NA NA NA hsa-miR-18a-5p SDC4 1.37435209536521 9.2173853686829e-06 -0.752957409763706 5.23236535490951e-05 MirTarget -0.198277142810285 1.39010888706595e-11 NA NA NA hsa-miR-301a-3p SDC4 2.70198002906399 1.56420889710984e-14 -0.752957409763706 5.23236535490951e-05 MirTarget -0.14039925041927 1.64236171671655e-06 NA NA NA hsa-miR-454-3p SDC4 1.49453641052169 4.46235742871434e-09 -0.752957409763706 5.23236535490951e-05 MirTarget -0.168962385042651 2.09734924277719e-05 NA NA NA hsa-miR-629-5p SDC4 1.31657090341737 1.45711558652127e-12 -0.752957409763706 5.23236535490951e-05 MirTarget -0.169233715544322 0.000190837094466722 NA NA NA hsa-miR-769-3p SDC4 0.452126659761753 0.0748150639143322 -0.752957409763706 5.23236535490951e-05 PITA;miRNATAP -0.121372994452679 0.000389768010158325 NA NA NA hsa-miR-942-5p SDC4 -0.0372813055050076 0.870631058767894 -0.752957409763706 5.23236535490951e-05 MirTarget -0.173659714426636 6.77389628832566e-06 NA NA NA hsa-miR-30b-5p SERPINE1 0.358144314839612 0.138026229059594 -0.114178653022812 0.73682517077286 MirTarget -0.358064427205798 2.30487975154751e-08 25170877 miR-30b may function as a novel tumor suppressor gene in gastric cancer by targeting PAI-1 and regulating the apoptosis of cancer cells gastric cancer hsa-miR-30c-5p SERPINE1 -0.327319105755825 0.123595832152687 -0.114178653022812 0.73682517077286 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.284046002981584 0.00011264609085013 NA NA NA hsa-miR-30d-5p SERPINE1 -0.920901858717441 3.50898334321668e-05 -0.114178653022812 0.73682517077286 miRNATAP -0.387251756384648 2.03451245658885e-08 NA NA NA hsa-miR-335-3p SERPINE2 1.51116383169018 6.88553098788624e-13 0.568200017257809 0.0484367988596067 MirTarget -0.176895635259338 0.00413164890710402 NA NA NA hsa-miR-429 SERPINE2 2.3794516574089 1.72813419703734e-13 0.568200017257809 0.0484367988596067 miRanda -0.146246703935999 0.000727652233837596 NA NA NA hsa-miR-146b-5p SFRP1 1.0922867893808 5.63754607494775e-06 -2.08752885738513 5.38679141051593e-05 MirTarget -0.52942072100834 6.32795389015505e-08 NA NA NA hsa-miR-16-1-3p SFRP1 1.50034693398929 6.63958242991125e-10 -2.08752885738513 5.38679141051593e-05 MirTarget -0.484182161826445 5.65968227514651e-05 NA NA NA hsa-miR-182-5p SFRP1 3.21839823004635 5.13049145201115e-39 -2.08752885738513 5.38679141051593e-05 mirMAP -0.270831612243815 0.00245046517911601 NA NA NA hsa-miR-29a-5p SFRP1 1.89519956688438 1.03453349363915e-11 -2.08752885738513 5.38679141051593e-05 mirMAP -0.549369602929202 3.46808310125807e-08 NA NA NA hsa-miR-96-5p SFRP1 3.0381097138467 4.40362891630201e-24 -2.08752885738513 5.38679141051593e-05 mirMAP -0.377228057292009 1.50643419827674e-05 NA NA NA hsa-miR-144-5p SFRP4 -1.3899604395726 0.000237414824562107 0.502900557158704 0.215273865000971 MirTarget -0.231374332123845 2.00145037239657e-06 NA NA NA hsa-miR-26b-5p SFRP4 0.72362441215247 4.7794659748036e-05 0.502900557158704 0.215273865000971 miRNAWalker2_validate -0.306869750257348 0.00345714161336382 NA NA NA hsa-miR-532-5p SFRP4 0.576620898517708 0.0023245812680956 0.502900557158704 0.215273865000971 MirTarget -0.293705784842898 0.00297601608882942 NA NA NA hsa-miR-16-2-3p SGCB 0.503964803530872 0.0263648405197492 -1.15227772188264 2.76328051577303e-11 mirMAP -0.141698988042984 0.000269238651706859 NA NA NA hsa-miR-182-5p SGCB 3.21839823004635 5.13049145201115e-39 -1.15227772188264 2.76328051577303e-11 mirMAP -0.178761656961935 2.2239282306644e-09 NA NA NA hsa-miR-21-5p SGCB 4.38165933891779 1.52536633902505e-92 -1.15227772188264 2.76328051577303e-11 miRNAWalker2_validate -0.22230635449862 1.91179943491579e-13 NA NA NA hsa-miR-30c-5p SGCB -0.327319105755825 0.123595832152687 -1.15227772188264 2.76328051577303e-11 miRNATAP -0.162924744397523 2.0250143933202e-05 NA NA NA hsa-miR-32-5p SGCB 0.876853679269853 6.04859399018691e-05 -1.15227772188264 2.76328051577303e-11 mirMAP -0.122533789365956 0.00232718667492204 24348862 microRNA 32 inhibits the proliferation and invasion of the SGC 7901 gastric cancer cell line in vitro gastric cancer hsa-miR-335-3p SGCB 1.51116383169018 6.88553098788624e-13 -1.15227772188264 2.76328051577303e-11 mirMAP -0.191343497417181 3.27131311780252e-07 NA NA NA hsa-miR-429 SGCB 2.3794516574089 1.72813419703734e-13 -1.15227772188264 2.76328051577303e-11 miRanda;miRNATAP -0.117464996251944 8.77201271731248e-06 NA NA NA hsa-miR-576-5p SGCB 1.02693643167056 1.14846964470173e-06 -1.15227772188264 2.76328051577303e-11 mirMAP -0.20729246728152 4.22002712203998e-08 NA NA NA hsa-miR-590-3p SGCB 0.83851360565783 0.00129224433453587 -1.15227772188264 2.76328051577303e-11 miRNAWalker2_validate;miRanda;mirMAP -0.116564681345936 0.00179806546607513 NA NA NA hsa-miR-103a-3p SGCD 0.538497806383155 1.88134691850591e-05 -1.50580144752869 5.97211906870455e-07 mirMAP -0.618527963929081 2.88264041292816e-08 NA NA NA hsa-miR-106a-5p SGCD 1.3902608059488 6.07931522284525e-05 -1.50580144752869 5.97211906870455e-07 mirMAP -0.349731554567629 1.17192009996345e-15 NA NA NA hsa-miR-106b-5p SGCD 1.47447672652218 1.32004094930462e-13 -1.50580144752869 5.97211906870455e-07 mirMAP -0.597725799277234 2.20675480225973e-19 NA NA NA hsa-miR-107 SGCD 0.658676029898313 5.11480446318819e-07 -1.50580144752869 5.97211906870455e-07 mirMAP -0.738997729684911 2.30242032930283e-12 NA NA NA hsa-miR-130b-5p SGCD 1.53645187062942 1.10498816261505e-08 -1.50580144752869 5.97211906870455e-07 mirMAP -0.250696790147836 9.12681023334554e-07 NA NA NA hsa-miR-148b-5p SGCD 1.39335695292409 2.13220380550073e-07 -1.50580144752869 5.97211906870455e-07 mirMAP -0.479253041168691 1.99384917370817e-15 NA NA NA hsa-miR-15a-5p SGCD 1.62575353599172 1.55312121019827e-19 -1.50580144752869 5.97211906870455e-07 miRNATAP -0.483522902411551 6.84777326476086e-11 NA NA NA hsa-miR-15b-5p SGCD -1.25935038177398 1.83460220856901e-12 -1.50580144752869 5.97211906870455e-07 miRNATAP -0.245940332289023 0.00143775924093746 NA NA NA hsa-miR-16-2-3p SGCD 0.503964803530872 0.0263648405197492 -1.50580144752869 5.97211906870455e-07 mirMAP -0.436157634002408 4.23977918455309e-11 NA NA NA hsa-miR-16-5p SGCD 0.749619098384047 4.11649450706988e-06 -1.50580144752869 5.97211906870455e-07 miRNATAP -0.564667363944171 2.57343464581567e-11 NA NA NA hsa-miR-17-5p SGCD 2.07078488653279 2.77403038572568e-19 -1.50580144752869 5.97211906870455e-07 mirMAP -0.577211458138292 3.40015271265841e-25 NA NA NA hsa-miR-19a-3p SGCD 2.11776595911517 7.07663078397156e-10 -1.50580144752869 5.97211906870455e-07 mirMAP -0.382277423062366 2.06496381081532e-16 NA NA NA hsa-miR-19b-3p SGCD 2.10868505662119 5.40846613768389e-17 -1.50580144752869 5.97211906870455e-07 mirMAP -0.402073611492799 4.80382020163794e-13 NA NA NA hsa-miR-200b-3p SGCD 1.55157578247391 4.83790020897188e-09 -1.50580144752869 5.97211906870455e-07 mirMAP -0.185551453644861 0.000366187318488521 NA NA NA hsa-miR-200c-3p SGCD 0.380533388300368 0.0842181838538353 -1.50580144752869 5.97211906870455e-07 mirMAP -0.37736995996374 2.16607411668237e-09 NA NA NA hsa-miR-20a-5p SGCD 2.64649625616975 5.1469418982085e-27 -1.50580144752869 5.97211906870455e-07 mirMAP -0.478171534829146 2.84451783935634e-20 NA NA NA hsa-miR-20b-5p SGCD 1.35770573270947 0.00260808530013016 -1.50580144752869 5.97211906870455e-07 mirMAP -0.195732000224618 1.23550784231185e-09 NA NA NA hsa-miR-21-3p SGCD 2.54206008030157 1.11598785398763e-30 -1.50580144752869 5.97211906870455e-07 mirMAP -0.271347997240847 4.70578254087706e-06 NA NA NA hsa-miR-25-3p SGCD 0.361927330834176 0.0163670566170988 -1.50580144752869 5.97211906870455e-07 mirMAP -0.616733139963573 2.45706480824432e-11 NA NA NA hsa-miR-26b-5p SGCD 0.72362441215247 4.7794659748036e-05 -1.50580144752869 5.97211906870455e-07 miRNATAP -0.267946293190304 0.000676336501233259 NA NA NA hsa-miR-29a-5p SGCD 1.89519956688438 1.03453349363915e-11 -1.50580144752869 5.97211906870455e-07 mirMAP -0.264071930116124 6.75880449233059e-06 NA NA NA hsa-miR-29b-1-5p SGCD 1.71024742617744 3.64915691793611e-09 -1.50580144752869 5.97211906870455e-07 mirMAP -0.246047272700732 1.86113720217354e-07 NA NA NA hsa-miR-32-5p SGCD 0.876853679269853 6.04859399018691e-05 -1.50580144752869 5.97211906870455e-07 mirMAP -0.408434926063897 2.57154598752419e-09 NA NA NA hsa-miR-331-5p SGCD 0.578237334664505 0.00131211239210882 -1.50580144752869 5.97211906870455e-07 mirMAP -0.430131561581543 6.34839413533639e-08 NA NA NA hsa-miR-335-3p SGCD 1.51116383169018 6.88553098788624e-13 -1.50580144752869 5.97211906870455e-07 mirMAP -0.532873189187079 3.47977917395917e-17 NA NA NA hsa-miR-335-5p SGCD -0.466533891325811 0.0676987038122831 -1.50580144752869 5.97211906870455e-07 miRNAWalker2_validate;miRNATAP -0.250516547990587 4.52552622455424e-05 NA NA NA hsa-miR-339-5p SGCD 0.536997313601114 0.0488090394176611 -1.50580144752869 5.97211906870455e-07 PITA;miRNATAP -0.144223451059073 0.00518362556743243 NA NA NA hsa-miR-33a-5p SGCD 2.80127809675219 5.09053890529424e-12 -1.50580144752869 5.97211906870455e-07 mirMAP;miRNATAP -0.217679304355254 1.54085369467032e-07 NA NA NA hsa-miR-362-3p SGCD 0.194097672030785 0.52808475179225 -1.50580144752869 5.97211906870455e-07 miRNATAP -0.152902124590936 0.00757792712900919 NA NA NA hsa-miR-363-3p SGCD -0.301366430789287 0.414451883803084 -1.50580144752869 5.97211906870455e-07 mirMAP -0.165867340901427 1.24473688747792e-05 NA NA NA hsa-miR-374a-3p SGCD 1.73882813668241 1.57901646296214e-13 -1.50580144752869 5.97211906870455e-07 mirMAP;miRNATAP -0.162389049368885 0.00526810237302527 NA NA NA hsa-miR-429 SGCD 2.3794516574089 1.72813419703734e-13 -1.50580144752869 5.97211906870455e-07 mirMAP -0.204494933795522 7.46564853579619e-06 NA NA NA hsa-miR-500a-5p SGCD 0.648155655714409 0.0104657432932038 -1.50580144752869 5.97211906870455e-07 mirMAP -0.248253175597689 1.18722769288083e-05 NA NA NA hsa-miR-532-5p SGCD 0.576620898517708 0.0023245812680956 -1.50580144752869 5.97211906870455e-07 PITA -0.309223721544282 2.96866182302748e-05 NA NA NA hsa-miR-576-5p SGCD 1.02693643167056 1.14846964470173e-06 -1.50580144752869 5.97211906870455e-07 mirMAP -0.471330422418564 2.81885692286051e-13 NA NA NA hsa-miR-582-3p SGCD 1.70881364237226 1.26508456000083e-06 -1.50580144752869 5.97211906870455e-07 mirMAP -0.195766599037391 5.25024182197864e-07 NA NA NA hsa-miR-589-3p SGCD 1.34253876396688 1.84935927493927e-05 -1.50580144752869 5.97211906870455e-07 mirMAP -0.180648898480495 7.81152706814169e-05 NA NA NA hsa-miR-590-3p SGCD 0.83851360565783 0.00129224433453587 -1.50580144752869 5.97211906870455e-07 PITA;miRanda;mirMAP;miRNATAP -0.384829723233609 1.44137896461201e-09 NA NA NA hsa-miR-590-5p SGCD 2.07441240363458 4.95240551694843e-14 -1.50580144752869 5.97211906870455e-07 miRanda -0.452430031790188 5.30392284227053e-14 NA NA NA hsa-miR-625-3p SGCD 0.945502348922534 1.12486088865896e-05 -1.50580144752869 5.97211906870455e-07 mirMAP -0.224287614850284 0.000540048421744713 NA NA NA hsa-miR-628-5p SGCD 1.06173574237323 4.67541261016756e-06 -1.50580144752869 5.97211906870455e-07 miRNATAP -0.209890409391216 0.00361014572710419 NA NA NA hsa-miR-7-1-3p SGCD 2.61364240402652 1.98959237815786e-32 -1.50580144752869 5.97211906870455e-07 mirMAP -0.423182055610165 5.87042030602642e-12 NA NA NA hsa-miR-9-5p SGCD 4.99250901331516 2.59132733422801e-19 -1.50580144752869 5.97211906870455e-07 mirMAP;miRNATAP -0.118936863477917 7.27152711774047e-07 NA NA NA hsa-miR-92a-3p SGCD -0.136362762339122 0.493412263619364 -1.50580144752869 5.97211906870455e-07 mirMAP -0.444623761105247 1.92351223263325e-10 NA NA NA hsa-miR-93-5p SGCD 1.50844106515467 1.83836866996875e-12 -1.50580144752869 5.97211906870455e-07 mirMAP -0.563262143255637 7.8678562507309e-20 NA NA NA hsa-miR-590-3p SGCG 0.83851360565783 0.00129224433453587 -4.71143613041213 6.87009215375187e-30 miRanda -0.415466513448745 8.24940146115072e-06 NA NA NA hsa-miR-590-5p SGCG 2.07441240363458 4.95240551694843e-14 -4.71143613041213 6.87009215375187e-30 miRanda -0.491966546497089 2.72715969948932e-08 NA NA NA hsa-miR-218-5p SLC6A8 -0.281408491748349 0.259553612322657 1.30526386083526 2.77993704729875e-05 mirMAP -0.261691700894944 9.98182471471709e-06 NA NA NA hsa-miR-200b-3p SLIT2 1.55157578247391 4.83790020897188e-09 -3.09595790742534 6.35623024930929e-18 TargetScan -0.176318044586741 0.00569748078788406 NA NA NA hsa-miR-26b-3p SLIT2 1.37388760789373 8.32526977075803e-09 -3.09595790742534 6.35623024930929e-18 miRNATAP -0.214281742137152 0.00253332077597997 NA NA NA hsa-miR-450b-5p SLIT2 1.69248953402469 1.96052058003353e-07 -3.09595790742534 6.35623024930929e-18 miRNATAP -0.270350802874305 2.94502032022436e-06 NA NA NA hsa-miR-576-5p SLIT2 1.02693643167056 1.14846964470173e-06 -3.09595790742534 6.35623024930929e-18 mirMAP -0.447601794563688 1.9902217486524e-08 NA NA NA hsa-miR-590-3p SLIT2 0.83851360565783 0.00129224433453587 -3.09595790742534 6.35623024930929e-18 miRanda -0.496834089199112 1.44683575522823e-10 NA NA NA hsa-miR-130b-3p SLIT3 1.83046548750752 5.04753914574694e-13 -2.95831703999917 4.1545446622722e-16 mirMAP -0.66089727976261 7.28548184809973e-23 NA NA NA hsa-miR-130b-5p SLIT3 1.53645187062942 1.10498816261505e-08 -2.95831703999917 4.1545446622722e-16 mirMAP -0.420320661542984 1.42237919784963e-11 NA NA NA hsa-miR-148b-5p SLIT3 1.39335695292409 2.13220380550073e-07 -2.95831703999917 4.1545446622722e-16 mirMAP -0.432018877730142 1.08688320136106e-08 NA NA NA hsa-miR-16-2-3p SLIT3 0.503964803530872 0.0263648405197492 -2.95831703999917 4.1545446622722e-16 mirMAP -0.355061064024944 1.71459929366396e-05 NA NA NA hsa-miR-192-5p SLIT3 2.03412119423736 1.6357945826287e-05 -2.95831703999917 4.1545446622722e-16 mirMAP -0.146087444314768 5.32487959792576e-05 NA NA NA hsa-miR-200c-5p SLIT3 1.7188514281688 1.38603090488265e-12 -2.95831703999917 4.1545446622722e-16 mirMAP -0.449577275804437 5.52683363127575e-11 NA NA NA hsa-miR-28-5p SLIT3 1.19639196514745 4.59365801666536e-18 -2.95831703999917 4.1545446622722e-16 miRanda -0.441729834939455 0.000297587696243139 NA NA NA hsa-miR-301a-3p SLIT3 2.70198002906399 1.56420889710984e-14 -2.95831703999917 4.1545446622722e-16 mirMAP -0.383082796277823 4.64534781097824e-11 NA NA NA hsa-miR-335-3p SLIT3 1.51116383169018 6.88553098788624e-13 -2.95831703999917 4.1545446622722e-16 mirMAP -0.523586549911155 3.46852698331035e-11 NA NA NA hsa-miR-374b-3p SLIT3 -0.157526212601818 0.538677664999491 -2.95831703999917 4.1545446622722e-16 mirMAP -0.21644960302844 0.0086088129094186 NA NA NA hsa-miR-429 SLIT3 2.3794516574089 1.72813419703734e-13 -2.95831703999917 4.1545446622722e-16 miRNATAP -0.275395314460377 9.30547619985836e-07 NA NA NA hsa-miR-454-3p SLIT3 1.49453641052169 4.46235742871434e-09 -2.95831703999917 4.1545446622722e-16 mirMAP -0.423204078619756 9.57508600331417e-08 NA NA NA hsa-miR-542-3p SLIT3 1.62226640768239 2.6427102465476e-10 -2.95831703999917 4.1545446622722e-16 mirMAP -0.266466665782082 5.34917987543139e-05 NA NA NA hsa-miR-550a-3p SLIT3 0.0186193291188046 0.949896722138275 -2.95831703999917 4.1545446622722e-16 mirMAP -0.209010940236772 0.00053573109535417 NA NA NA hsa-miR-589-3p SLIT3 1.34253876396688 1.84935927493927e-05 -2.95831703999917 4.1545446622722e-16 mirMAP -0.234998552996832 3.00010550046049e-05 NA NA NA hsa-miR-590-3p SLIT3 0.83851360565783 0.00129224433453587 -2.95831703999917 4.1545446622722e-16 miRanda;mirMAP -0.518525389308352 3.10354165271044e-11 NA NA NA hsa-miR-590-5p SLIT3 2.07441240363458 4.95240551694843e-14 -2.95831703999917 4.1545446622722e-16 miRanda -0.574547875347132 7.95736849073738e-15 NA NA NA hsa-miR-625-5p SLIT3 1.38208523187596 6.28473801440755e-07 -2.95831703999917 4.1545446622722e-16 mirMAP -0.254605309516416 0.000220405201140759 NA NA NA hsa-miR-9-5p SLIT3 4.99250901331516 2.59132733422801e-19 -2.95831703999917 4.1545446622722e-16 mirMAP -0.19634520761156 1.97231636190033e-11 NA NA NA hsa-miR-96-5p SLIT3 3.0381097138467 4.40362891630201e-24 -2.95831703999917 4.1545446622722e-16 TargetScan -0.576188002219602 1.98232047528863e-21 NA NA NA hsa-miR-107 SNAI2 0.658676029898313 5.11480446318819e-07 -0.554815854836026 0.0572510642413704 miRanda -0.453280671767904 9.47828797287328e-06 NA NA NA hsa-miR-148b-3p SNAI2 0.483970528590224 0.0026495409465901 -0.554815854836026 0.0572510642413704 miRNAWalker2_validate -0.556715968710761 1.39573841121991e-11 NA NA NA hsa-miR-182-5p SNAI2 3.21839823004635 5.13049145201115e-39 -0.554815854836026 0.0572510642413704 miRNAWalker2_validate;miRNATAP -0.27996146293031 1.54370882600273e-08 NA NA NA hsa-miR-200b-3p SNAI2 1.55157578247391 4.83790020897188e-09 -0.554815854836026 0.0572510642413704 TargetScan -0.443484841265163 2.179079103861e-20 NA NA NA hsa-miR-200c-3p SNAI2 0.380533388300368 0.0842181838538353 -0.554815854836026 0.0572510642413704 miRNATAP -0.454021736927152 2.59527605282676e-14 NA NA NA hsa-miR-335-3p SNAI2 1.51116383169018 6.88553098788624e-13 -0.554815854836026 0.0572510642413704 mirMAP -0.277154551162383 8.12434222553235e-06 NA NA NA hsa-miR-375 SNAI2 0.615547997686534 0.149199273675144 -0.554815854836026 0.0572510642413704 miRanda -0.275636396308253 7.67532856156687e-20 NA NA NA hsa-miR-429 SNAI2 2.3794516574089 1.72813419703734e-13 -0.554815854836026 0.0572510642413704 PITA;miRanda;miRNATAP -0.340017457669358 1.60139306581284e-15 NA NA NA hsa-miR-532-5p SNAI2 0.576620898517708 0.0023245812680956 -0.554815854836026 0.0572510642413704 PITA -0.391801913447513 2.51582546466248e-08 NA NA NA hsa-miR-96-5p SNAI2 3.0381097138467 4.40362891630201e-24 -0.554815854836026 0.0572510642413704 miRNATAP -0.265643619461592 4.47304111611125e-08 NA NA NA hsa-miR-142-5p SNTB1 1.29672439149353 4.0768822158894e-06 -0.186313855948204 0.434629787340541 mirMAP -0.130313388396379 0.00185217474399164 NA NA NA hsa-miR-16-2-3p SNTB1 0.503964803530872 0.0263648405197492 -0.186313855948204 0.434629787340541 mirMAP -0.222859195602465 2.02224661328934e-05 NA NA NA hsa-miR-320b SNTB1 0.226640952564488 0.378818692487242 -0.186313855948204 0.434629787340541 MirTarget;miRanda;miRNATAP -0.125276096662847 0.00332751485347097 NA NA NA hsa-miR-381-3p SNTB1 0.794445476378413 0.0133749527359742 -0.186313855948204 0.434629787340541 mirMAP -0.101530976814614 0.00289617058228699 NA NA NA hsa-miR-421 SNTB1 0.170525317701774 0.535277026680289 -0.186313855948204 0.434629787340541 miRanda -0.124583791384995 0.00410372666439406 NA NA NA hsa-miR-576-5p SNTB1 1.02693643167056 1.14846964470173e-06 -0.186313855948204 0.434629787340541 mirMAP -0.284327246129392 2.38409569011518e-08 NA NA NA hsa-miR-590-3p SNTB1 0.83851360565783 0.00129224433453587 -0.186313855948204 0.434629787340541 MirTarget;miRanda;miRNATAP -0.191253770374611 0.000139023584220307 NA NA NA hsa-miR-590-5p SNTB1 2.07441240363458 4.95240551694843e-14 -0.186313855948204 0.434629787340541 miRanda -0.206735693645486 1.56154550668762e-05 NA NA NA hsa-miR-19a-3p SPARC 2.11776595911517 7.07663078397156e-10 -0.439135084141812 0.0478149166021627 mirMAP -0.183641709523272 1.04257631965908e-07 NA NA NA hsa-miR-29a-3p SPARC 0.101650412194573 0.573201097011668 -0.439135084141812 0.0478149166021627 miRNAWalker2_validate;miRTarBase;miRNATAP -0.177409753463295 0.00187652358225428 23023935 microRNA 29a suppresses cell proliferation by targeting SPARC in hepatocellular carcinoma; Dual-luciferase reporter assays indicated that the SPARC mRNA 3'UTR was directly targeted by miR-29a since the mutated 3'UTR was not affected; Silencing SPARC expression by RNAi knockdown resulted in a similar effect as miR-29a overexpression on hepatocellular carcinoma HCC cell growth regulation liver cancer hsa-miR-29b-3p SPARC 3.10527711861309 3.01242507282711e-32 -0.439135084141812 0.0478149166021627 miRNATAP -0.167735490157526 3.18974335348508e-06 NA NA NA hsa-miR-3065-5p SPARC 0.653308707552535 0.0999497219778851 -0.439135084141812 0.0478149166021627 mirMAP -0.152779767365617 3.23442170156209e-08 NA NA NA hsa-miR-335-3p SPARC 1.51116383169018 6.88553098788624e-13 -0.439135084141812 0.0478149166021627 MirTarget -0.254249439861901 6.24698230721343e-08 NA NA NA hsa-miR-361-5p SPARC 0.21454431962475 0.0800957579368424 -0.439135084141812 0.0478149166021627 MirTarget -0.228870238183615 0.00714365052939967 NA NA NA hsa-miR-362-5p SPARC 0.658947634569393 0.0243306847205756 -0.439135084141812 0.0478149166021627 TargetScan -0.184724080760881 1.86394953460089e-07 NA NA NA hsa-miR-7-1-3p SPARC 2.61364240402652 1.98959237815786e-32 -0.439135084141812 0.0478149166021627 mirMAP -0.245052969148243 5.62002276946174e-08 NA NA NA hsa-miR-126-5p SPOCK1 0.851637714492907 0.000391373420568359 1.70903703280186 0.000671735079673281 mirMAP -0.342021420445848 0.000384693236083669 NA NA NA hsa-miR-139-5p SPOCK1 -2.26625553116965 7.22375119369519e-16 1.70903703280186 0.000671735079673281 PITA;miRanda;miRNATAP -0.352329313985862 9.80393012228714e-06 NA NA NA hsa-miR-2110 SPOCK1 -1.92124860612475 1.1464887721828e-12 1.70903703280186 0.000671735079673281 MirTarget -0.344433674800509 4.54701210424289e-05 NA NA NA hsa-miR-26a-5p SPOCK1 -0.126411409001078 0.440028840408711 1.70903703280186 0.000671735079673281 mirMAP -0.525501285411029 0.000242736813580234 NA NA NA hsa-miR-3065-5p SPOCK1 0.653308707552535 0.0999497219778851 1.70903703280186 0.000671735079673281 MirTarget;miRNATAP -0.425409355703082 9.15120917337549e-12 NA NA NA hsa-miR-30a-3p SPOCK1 -2.54042202792785 2.9111625410859e-18 1.70903703280186 0.000671735079673281 mirMAP -0.515621070804235 7.24103764415482e-12 NA NA NA hsa-miR-30d-3p SPOCK1 0.00396376345349925 0.986457040013182 1.70903703280186 0.000671735079673281 mirMAP -0.935733852849314 5.47705116682212e-18 NA NA NA hsa-miR-30e-3p SPOCK1 -0.104420043859122 0.526240453209293 1.70903703280186 0.000671735079673281 mirMAP -0.620903215619756 1.20116418138642e-05 NA NA NA hsa-miR-326 SPOCK1 -0.992397386750901 0.00335173765975096 1.70903703280186 0.000671735079673281 MirTarget;miRanda -0.274043726478246 5.86610685354923e-05 NA NA NA hsa-miR-375 SPOCK1 0.615547997686534 0.149199273675144 1.70903703280186 0.000671735079673281 miRNATAP -0.294799089519313 4.24212969036164e-08 NA NA NA hsa-miR-429 SPOCK1 2.3794516574089 1.72813419703734e-13 1.70903703280186 0.000671735079673281 miRNATAP -0.242146409851719 0.00143056591718 NA NA NA hsa-miR-501-3p SPOCK1 -0.0405952693028064 0.866802243505833 1.70903703280186 0.000671735079673281 PITA;TargetScan;miRNATAP -0.379106782592379 7.94932883190957e-05 NA NA NA hsa-miR-502-3p SPOCK1 -0.262270070977708 0.161760375279961 1.70903703280186 0.000671735079673281 PITA;miRNATAP -0.785271211016898 1.59449373757925e-10 NA NA NA hsa-miR-139-5p SPP1 -2.26625553116965 7.22375119369519e-16 4.61563851918881 1.35599631950767e-21 miRanda -0.473602076232976 2.29122161191296e-09 NA NA NA hsa-miR-335-5p SPP1 -0.466533891325811 0.0676987038122831 4.61563851918881 1.35599631950767e-21 miRNAWalker2_validate -0.473516574726313 3.22030261769506e-06 NA NA NA hsa-miR-128-3p TAGLN 1.03509868349735 2.11606310588315e-10 -0.950695135818517 0.000113944967497651 miRNAWalker2_validate -0.325411465340276 2.23842216163873e-06 NA NA NA hsa-miR-625-5p TAGLN 1.38208523187596 6.28473801440755e-07 -0.950695135818517 0.000113944967497651 mirMAP -0.146587826252764 0.00127248377921493 NA NA NA hsa-miR-7-5p TAGLN 0.343825848926135 0.435063427976906 -0.950695135818517 0.000113944967497651 miRNAWalker2_validate -0.164934204140448 2.64703849558367e-07 NA NA NA hsa-miR-26b-5p TGFBI 0.72362441215247 4.7794659748036e-05 -0.0566239980222178 0.849288876912504 miRNAWalker2_validate -0.221597088676754 0.00399631772033163 NA NA NA hsa-miR-362-3p TGFBI 0.194097672030785 0.52808475179225 -0.0566239980222178 0.849288876912504 miRanda -0.179718850452282 0.00125898908459268 NA NA NA hsa-miR-429 TGFBI 2.3794516574089 1.72813419703734e-13 -0.0566239980222178 0.849288876912504 miRanda -0.339034936609727 7.04814561219783e-15 NA NA NA hsa-miR-15a-5p TGFBR3 1.62575353599172 1.55312121019827e-19 -3.00237515277085 4.40834583299503e-24 MirTarget;miRNATAP -0.311761657076606 5.08914930500035e-05 NA NA NA hsa-miR-16-2-3p TGFBR3 0.503964803530872 0.0263648405197492 -3.00237515277085 4.40834583299503e-24 mirMAP -0.20928613564116 0.00240552004074186 NA NA NA hsa-miR-182-5p TGFBR3 3.21839823004635 5.13049145201115e-39 -3.00237515277085 4.40834583299503e-24 miRNATAP -0.534083585610694 8.61423882701029e-26 NA NA NA hsa-miR-186-5p TGFBR3 0.852175445703945 6.88885738584309e-10 -3.00237515277085 4.40834583299503e-24 MirTarget -0.323350902803729 0.0018095068634619 NA NA NA hsa-miR-18a-5p TGFBR3 1.37435209536521 9.2173853686829e-06 -3.00237515277085 4.40834583299503e-24 MirTarget -0.341444481169303 2.82084364179038e-12 NA NA NA hsa-miR-193b-3p TGFBR3 1.10444771306846 0.000822888533401377 -3.00237515277085 4.40834583299503e-24 miRNAWalker2_validate;MirTarget;miRNATAP -0.229932194565447 8.29387328637064e-08 NA NA NA hsa-miR-21-5p TGFBR3 4.38165933891779 1.52536633902505e-92 -3.00237515277085 4.40834583299503e-24 miRNAWalker2_validate -0.52936321276773 3.12764271220347e-24 NA NA NA hsa-miR-29a-5p TGFBR3 1.89519956688438 1.03453349363915e-11 -3.00237515277085 4.40834583299503e-24 mirMAP -0.418871090100243 1.40022947023382e-12 NA NA NA hsa-miR-335-3p TGFBR3 1.51116383169018 6.88553098788624e-13 -3.00237515277085 4.40834583299503e-24 mirMAP -0.37864161389012 9.8609617173827e-09 NA NA NA hsa-miR-339-5p TGFBR3 0.536997313601114 0.0488090394176611 -3.00237515277085 4.40834583299503e-24 miRanda -0.167582506637513 0.00149305251240295 NA NA NA hsa-miR-34a-5p TGFBR3 1.40588612517769 8.60097477768592e-12 -3.00237515277085 4.40834583299503e-24 miRNATAP -0.220917863649038 0.00126137523003733 NA NA NA hsa-miR-3607-3p TGFBR3 2.4103172144469 2.69039449048047e-08 -3.00237515277085 4.40834583299503e-24 mirMAP -0.13868711567953 1.94498344149779e-05 NA NA NA hsa-miR-424-5p TGFBR3 1.26485330287919 6.1498991028257e-06 -3.00237515277085 4.40834583299503e-24 MirTarget;miRNATAP -0.308487223690823 7.9775903952702e-10 NA NA NA hsa-miR-429 TGFBR3 2.3794516574089 1.72813419703734e-13 -3.00237515277085 4.40834583299503e-24 miRanda -0.185472108907033 7.52958455113645e-05 NA NA NA hsa-miR-450b-5p TGFBR3 1.69248953402469 1.96052058003353e-07 -3.00237515277085 4.40834583299503e-24 mirMAP -0.256214649224131 1.14421073652016e-07 NA NA NA hsa-miR-589-3p TGFBR3 1.34253876396688 1.84935927493927e-05 -3.00237515277085 4.40834583299503e-24 MirTarget -0.257060022516625 3.13989467717079e-08 NA NA NA hsa-miR-590-3p TGFBR3 0.83851360565783 0.00129224433453587 -3.00237515277085 4.40834583299503e-24 MirTarget;miRanda;mirMAP -0.415920018148628 1.5393260290838e-10 NA NA NA hsa-miR-590-5p TGFBR3 2.07441240363458 4.95240551694843e-14 -3.00237515277085 4.40834583299503e-24 miRanda -0.505798449062716 1.39039454560219e-16 NA NA NA hsa-miR-625-5p TGFBR3 1.38208523187596 6.28473801440755e-07 -3.00237515277085 4.40834583299503e-24 MirTarget -0.212491025631798 0.000206167777723719 NA NA NA hsa-miR-7-1-3p TGFBR3 2.61364240402652 1.98959237815786e-32 -3.00237515277085 4.40834583299503e-24 mirMAP -0.408156424152396 1.01954949090426e-10 NA NA NA hsa-miR-98-5p TGFBR3 1.170602085804 1.09900501665229e-08 -3.00237515277085 4.40834583299503e-24 MirTarget -0.258302459628603 0.000280407027221654 NA NA NA hsa-miR-106b-5p TGM2 1.47447672652218 1.32004094930462e-13 -1.1676976863247 2.85691667538751e-07 MirTarget -0.345219452064294 1.32363244766489e-11 NA NA NA hsa-miR-17-5p TGM2 2.07078488653279 2.77403038572568e-19 -1.1676976863247 2.85691667538751e-07 MirTarget -0.241766014004812 3.19304510952629e-08 NA NA NA hsa-miR-20a-5p TGM2 2.64649625616975 5.1469418982085e-27 -1.1676976863247 2.85691667538751e-07 MirTarget -0.216283706486889 7.87983572216962e-08 NA NA NA hsa-miR-93-5p TGM2 1.50844106515467 1.83836866996875e-12 -1.1676976863247 2.85691667538751e-07 MirTarget -0.206175157008594 1.91700030475691e-05 NA NA NA hsa-miR-16-1-3p THBS1 1.50034693398929 6.63958242991125e-10 -0.930928104430071 0.00139531304277658 MirTarget -0.335212349500693 6.0842815757812e-07 NA NA NA hsa-miR-17-5p THBS1 2.07078488653279 2.77403038572568e-19 -0.930928104430071 0.00139531304277658 miRNAWalker2_validate -0.438129032548489 9.5201094057219e-16 NA NA NA hsa-miR-182-5p THBS1 3.21839823004635 5.13049145201115e-39 -0.930928104430071 0.00139531304277658 MirTarget -0.17203897957724 0.000598074099312019 24053448 Effects of anti miR 182 on TSP 1 expression in human colon cancer cells: there is a sense in antisense?; We investigate on the molecular mechanism by which miR-182 could regulate thrombospondin-1 TSP-1 expression a protein downregulated in CRC and inversely correlated with tumor vascularity and metastasis; miR-182 over-expressed in colorectal cancer CRC has like predictive target thrombospondin-1 TSP-1 a protein inversely correlated with tumor vascularity and metastasis that results downregulated in different types of cancer including CRC; We found that TSP-1 increased after transfection with anti-miR-182 and we showed that miR-182 targets TSP-1 3'UTR-mRNA in both cells; Our data suggest that miR-182 targets the anti-angiogenic factor TSP-1 and that anti-miR-182 determines an upregulation of TSP-1 expression in colon cancer cells metastasis colon cancer hsa-miR-186-5p THBS1 0.852175445703945 6.88885738584309e-10 -0.930928104430071 0.00139531304277658 mirMAP -0.519985070059 6.04454698272776e-08 NA NA NA hsa-miR-18a-5p THBS1 1.37435209536521 9.2173853686829e-06 -0.930928104430071 0.00139531304277658 MirTarget -0.297317863017191 9.33481417958521e-11 NA NA NA hsa-miR-19a-3p THBS1 2.11776595911517 7.07663078397156e-10 -0.930928104430071 0.00139531304277658 MirTarget;mirMAP -0.320107454551527 1.0910865655915e-12 NA NA NA hsa-miR-19b-3p THBS1 2.10868505662119 5.40846613768389e-17 -0.930928104430071 0.00139531304277658 MirTarget;mirMAP -0.394071669543936 1.30352702952378e-13 NA NA NA hsa-miR-200a-5p THBS1 2.26680634475411 1.52168554660094e-17 -0.930928104430071 0.00139531304277658 MirTarget -0.192969334171335 7.36724513214628e-05 NA NA NA hsa-miR-200b-5p THBS1 0.5652412449293 0.0273948420835934 -0.930928104430071 0.00139531304277658 MirTarget -0.190414406051537 0.000286594153768624 NA NA NA hsa-miR-20a-5p THBS1 2.64649625616975 5.1469418982085e-27 -0.930928104430071 0.00139531304277658 miRNAWalker2_validate -0.389697563087682 9.68073828210161e-15 NA NA NA hsa-miR-29b-1-5p THBS1 1.71024742617744 3.64915691793611e-09 -0.930928104430071 0.00139531304277658 mirMAP -0.174722185271877 0.000124277285903 NA NA NA hsa-miR-3065-5p THBS1 0.653308707552535 0.0999497219778851 -0.930928104430071 0.00139531304277658 MirTarget -0.146963541534871 6.23555676304228e-05 NA NA NA hsa-miR-32-5p THBS1 0.876853679269853 6.04859399018691e-05 -0.930928104430071 0.00139531304277658 mirMAP -0.378697285956757 8.57166070787422e-09 NA NA NA hsa-miR-335-3p THBS1 1.51116383169018 6.88553098788624e-13 -0.930928104430071 0.00139531304277658 mirMAP -0.277769513126927 8.06336576747616e-06 NA NA NA hsa-miR-338-3p THBS1 0.726843067232002 0.0506251324215494 -0.930928104430071 0.00139531304277658 MirTarget;PITA;miRanda -0.137206796252208 0.000139893109055389 NA NA NA hsa-miR-500a-5p THBS1 0.648155655714409 0.0104657432932038 -0.930928104430071 0.00139531304277658 mirMAP -0.266623772340649 8.55185956464653e-07 NA NA NA hsa-miR-576-5p THBS1 1.02693643167056 1.14846964470173e-06 -0.930928104430071 0.00139531304277658 mirMAP -0.283940645214832 6.42767093777526e-06 NA NA NA hsa-miR-590-3p THBS1 0.83851360565783 0.00129224433453587 -0.930928104430071 0.00139531304277658 miRanda -0.190498848920156 0.00206214930389577 NA NA NA hsa-miR-590-5p THBS1 2.07441240363458 4.95240551694843e-14 -0.930928104430071 0.00139531304277658 miRanda;mirMAP -0.246253114774633 2.83321183197093e-05 NA NA NA hsa-miR-664a-3p THBS1 0.443077463053857 0.0214248925850984 -0.930928104430071 0.00139531304277658 mirMAP -0.228448076947888 0.00112527165905494 NA NA NA hsa-miR-671-5p THBS1 2.24156654191798 2.10433241567652e-14 -0.930928104430071 0.00139531304277658 MirTarget -0.190134986140565 0.000356438440186681 NA NA NA hsa-miR-7-1-3p THBS1 2.61364240402652 1.98959237815786e-32 -0.930928104430071 0.00139531304277658 MirTarget;mirMAP -0.299067024820193 5.25045592977195e-07 NA NA NA hsa-miR-92a-3p THBS1 -0.136362762339122 0.493412263619364 -0.930928104430071 0.00139531304277658 miRNAWalker2_validate -0.339440045365484 4.84769739541811e-07 NA NA NA hsa-miR-106a-5p THBS2 1.3902608059488 6.07931522284525e-05 2.13303340663678 5.55214196969225e-10 MirTarget -0.141118825069235 0.00632866362209016 NA NA NA hsa-miR-139-5p THBS2 -2.26625553116965 7.22375119369519e-16 2.13303340663678 5.55214196969225e-10 miRanda -0.328833798121345 1.9873453443232e-09 NA NA NA hsa-miR-16-2-3p THBS2 0.503964803530872 0.0263648405197492 2.13303340663678 5.55214196969225e-10 mirMAP -0.269836760400924 0.000475097739448551 NA NA NA hsa-miR-29a-3p THBS2 0.101650412194573 0.573201097011668 2.13303340663678 5.55214196969225e-10 MirTarget -0.324285863811433 0.000313287451075819 NA NA NA hsa-miR-320a THBS2 -0.961144925954715 1.62478794429204e-08 2.13303340663678 5.55214196969225e-10 mirMAP -0.27353755909077 0.00366923961047422 NA NA NA hsa-miR-3614-5p THBS2 -1.19394699210224 2.53933783780868e-05 2.13303340663678 5.55214196969225e-10 miRNATAP -0.322232683205048 8.12599690622336e-09 NA NA NA hsa-miR-598-3p THBS2 -0.213242160655447 0.368994149341807 2.13303340663678 5.55214196969225e-10 MirTarget -0.193388031380303 0.00459994901259022 NA NA NA hsa-miR-338-3p THY1 0.726843067232002 0.0506251324215494 0.979094186639286 0.000140510245591974 mirMAP -0.123701704559457 0.000103332861390628 NA NA NA hsa-miR-423-5p THY1 -1.80309342242719 1.34791344187441e-19 0.979094186639286 0.000140510245591974 MirTarget -0.192975937635437 0.000803109281686876 NA NA NA hsa-miR-103a-3p TIMP3 0.538497806383155 1.88134691850591e-05 -2.29631053711947 1.46430697909437e-17 miRNAWalker2_validate;miRTarBase -0.494903172266988 1.34716705199864e-06 22783422 miR-103 inhibitor transfection increased the activity of the luciferase reporter assay containing the TIMP-3 3'-untranslated region UTR construct and increased the levels of the TIMP-3 protein but not its mRNA in endometrial cancer cell lines; Our data suggested that miR-103 post-transcriptionally downregulates the expression of the tumor suppressor TIMP-3 and stimulates growth and invasion in endometrial cancer cell lines endometrial cancer hsa-miR-106a-5p TIMP3 1.3902608059488 6.07931522284525e-05 -2.29631053711947 1.46430697909437e-17 miRNATAP -0.287839147387848 8.45469749188297e-13 NA NA NA hsa-miR-106b-5p TIMP3 1.47447672652218 1.32004094930462e-13 -2.29631053711947 1.46430697909437e-17 miRNATAP -0.495878535661135 5.65998781365929e-16 NA NA NA hsa-miR-16-1-3p TIMP3 1.50034693398929 6.63958242991125e-10 -2.29631053711947 1.46430697909437e-17 mirMAP -0.290108123661711 6.47628061983012e-06 NA NA NA hsa-miR-16-5p TIMP3 0.749619098384047 4.11649450706988e-06 -2.29631053711947 1.46430697909437e-17 miRNAWalker2_validate -0.464147241369006 2.47873454503938e-09 NA NA NA hsa-miR-20a-5p TIMP3 2.64649625616975 5.1469418982085e-27 -2.29631053711947 1.46430697909437e-17 miRNATAP -0.417480364924734 1.88558012195588e-18 NA NA NA hsa-miR-21-5p TIMP3 4.38165933891779 1.52536633902505e-92 -2.29631053711947 1.46430697909437e-17 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.295699211692005 8.53650160998618e-10 23936642;21820586;25720799;20346171;25587717 Genetic heterogeneity of breast cancer metastasis may be related to miR 21 regulation of TIMP 3 in translation; The aim of this study is to determine whether microRNA-21 miR-21 a specific microRNA implicated in multiple aspects of carcinogenesis promoted breast cancer metastasis by regulating the tissue inhibitor of metalloproteinase 3 TIMP-3 gene; Correlation analysis was performed between miR-21 and TIMP-3; There was significantly inverse correlation between miR-21 and TIMP-3 extracted from tissue;The effect of TIMP3 on miR-21-induced cell survival was determined by transfection with TIMP3 lacking 3' untranslated region and miR-21;We verified that HMGB1-induced expression of miR-21 in HCC provides a posttranscriptional repression of the matrix metalloproteinase MMP inhibitors RECK and TIMP3 which are known to impact HCC progression and metastases; Finally we found that inhibition of miR-21 in murine HMGB1-overexpressing HCC xenografts led to reduced tumor MMP activity through released repression of the miR-21 targets RECK and TIMP3 which ultimately impeded tumor progression;The aim of this study was to determine whether microRNA-21 miR-21 a specific microRNA implicated in multiple aspects of carcinogenesis impacts breast cancer invasion by regulating the tissue inhibitor of metalloproteinase 3 TIMP3 gene; In addition the regulation of tissue inhibitor of metalloproteinase 3 TIMP3 by miR-21 was evaluated by western blotting and luciferase assays; Evaluation of TIMP3 protein levels a peptidase involved in extarcellular matrix degredation inversely correlated with miR-21 expression; As knockdown of miR-21 increased TIMP3 protein expression and luciferase reporter activity our data suggests that miR-21 could promote invasion in breast cancer cells via its regulation of TIMP3;It was previously shown by our group that miR-21 a potential regulator of TIMP3 is over-expressed in cutaneous melanoma; It was therefore hypothesized that increased levels of miR-21 expression would lead to decreased expression of TIMP3 and thereby enhance the invasiveness of melanoma cells; Reduced expression of TIMP3 was achieved by siRNA knockdown and significantly enhanced invasion of melanoma cell lines mimicking the effects of miR-21 over-expression; Treatment of tumor cells with a linked nucleic acid antagomir to miR-21 inhibited tumor growth and increased tumor expression of TIMP3 in vivo in 01B74 Athymic NCr-nu/nu mice; This data shows that increased expression of miR-21 enhanced the invasive potential of melanoma cell lines through TIMP3 inhibition metastasis;tumorigenesis;poor survival;metastasis;progression;tumorigenesis; breast cancer;kidney renal cell cancer;liver cancer;breast cancer;melanoma hsa-miR-3200-3p TIMP3 0.521712783553188 0.134990592651885 -2.29631053711947 1.46430697909437e-17 mirMAP -0.103497489336562 0.00646943185988182 NA NA NA hsa-miR-3607-3p TIMP3 2.4103172144469 2.69039449048047e-08 -2.29631053711947 1.46430697909437e-17 MirTarget;miRNATAP -0.110183843227047 0.000150999166906014 NA NA NA hsa-miR-589-3p TIMP3 1.34253876396688 1.84935927493927e-05 -2.29631053711947 1.46430697909437e-17 mirMAP -0.144922188683539 0.000547323353175281 NA NA NA hsa-miR-590-3p TIMP3 0.83851360565783 0.00129224433453587 -2.29631053711947 1.46430697909437e-17 PITA;miRanda;miRNATAP -0.3192315561143 4.6030457777348e-08 NA NA NA hsa-miR-590-5p TIMP3 2.07441240363458 4.95240551694843e-14 -2.29631053711947 1.46430697909437e-17 MirTarget;PITA;miRanda;miRNATAP -0.341444156760979 8.02434225356165e-10 NA NA NA hsa-miR-660-5p TIMP3 2.04875198906126 1.08269480928897e-17 -2.29631053711947 1.46430697909437e-17 miRNATAP -0.223057081166816 2.57513102587396e-05 NA NA NA hsa-miR-7-1-3p TIMP3 2.61364240402652 1.98959237815786e-32 -2.29631053711947 1.46430697909437e-17 mirMAP -0.49820448196912 1.98664670783778e-19 NA NA NA hsa-miR-129-5p TNC -0.405735314747643 0.341485636033577 0.57965298093833 0.171283129464553 miRanda -0.187596516094653 4.1052565839279e-05 NA NA NA hsa-miR-330-3p TNC -0.716924999893351 0.000796236278616087 0.57965298093833 0.171283129464553 MirTarget -0.310850868827245 0.00063939941426808 NA NA NA hsa-miR-330-5p TNC 0.168520831101569 0.336433937906706 0.57965298093833 0.171283129464553 MirTarget;miRanda;miRNATAP -0.471873860124968 2.38473728160081e-05 NA NA NA hsa-miR-335-5p TNC -0.466533891325811 0.0676987038122831 0.57965298093833 0.171283129464553 miRNAWalker2_validate;miRTarBase -0.37131762732385 1.29415699469758e-05 NA NA NA hsa-miR-501-5p TNC 0.411357595674671 0.10435288464149 0.57965298093833 0.171283129464553 miRNATAP -0.305491650553852 7.02294431676545e-05 NA NA NA hsa-miR-141-3p TNFAIP3 3.36993755486106 5.42939251147195e-32 -0.896689347275363 5.76031953530272e-05 TargetScan -0.214508571084815 8.54662785004066e-11 NA NA NA hsa-miR-19b-3p TNFAIP3 2.10868505662119 5.40846613768389e-17 -0.896689347275363 5.76031953530272e-05 miRNATAP -0.152108378168279 0.000267726016253222 NA NA NA hsa-miR-27b-5p TNFAIP3 1.03511957999268 7.86187917705303e-11 -0.896689347275363 5.76031953530272e-05 miRNATAP -0.17973050614147 0.0051270355479406 NA NA NA hsa-miR-429 TNFAIP3 2.3794516574089 1.72813419703734e-13 -0.896689347275363 5.76031953530272e-05 miRanda -0.241088202394272 2.63042256001507e-13 NA NA NA hsa-miR-146b-5p TNFRSF11B 1.0922867893808 5.63754607494775e-06 -0.737099733237779 0.0282451381642891 miRanda -0.195532859573832 0.0022045192034451 NA NA NA hsa-miR-21-5p TNFRSF11B 4.38165933891779 1.52536633902505e-92 -0.737099733237779 0.0282451381642891 miRNAWalker2_validate -0.228645305978608 9.97304309169901e-05 NA NA NA hsa-miR-338-3p TNFRSF11B 0.726843067232002 0.0506251324215494 -0.737099733237779 0.0282451381642891 miRanda -0.183472925321859 9.01065806474825e-06 NA NA NA hsa-miR-576-5p TNFRSF11B 1.02693643167056 1.14846964470173e-06 -0.737099733237779 0.0282451381642891 PITA -0.223602049404559 0.00213346900459653 NA NA NA hsa-miR-107 TPM1 0.658676029898313 5.11480446318819e-07 -0.015042442856088 0.934129987328155 PITA;miRanda -0.207738924818588 0.00115943895490318 NA NA NA hsa-miR-146b-5p TPM1 1.0922867893808 5.63754607494775e-06 -0.015042442856088 0.934129987328155 miRanda -0.147165314873197 1.77993352618511e-05 NA NA NA hsa-miR-29a-3p TPM1 0.101650412194573 0.573201097011668 -0.015042442856088 0.934129987328155 miRNATAP -0.215025481020304 3.55025590629632e-06 NA NA NA hsa-miR-29b-3p TPM1 3.10527711861309 3.01242507282711e-32 -0.015042442856088 0.934129987328155 miRNATAP -0.130787523545823 9.17819064251729e-06 NA NA NA hsa-miR-34a-5p TPM1 1.40588612517769 8.60097477768592e-12 -0.015042442856088 0.934129987328155 miRNAWalker2_validate -0.135647548219896 0.000646102625175027 NA NA NA hsa-miR-96-5p TPM1 3.0381097138467 4.40362891630201e-24 -0.015042442856088 0.934129987328155 MirTarget;TargetScan;miRNATAP -0.101326492423407 0.000891201738121702 NA NA NA hsa-miR-16-5p TPM2 0.749619098384047 4.11649450706988e-06 -0.325945705289001 0.170555063267889 MirTarget -0.234252373433078 0.000477199582993802 NA NA NA hsa-miR-125a-5p TPM4 -1.04824536696301 3.97386082850476e-07 -0.591068644809193 7.40024842556886e-05 miRNAWalker2_validate -0.106501062277944 0.00128250554287408 NA NA NA hsa-miR-30c-5p TPM4 -0.327319105755825 0.123595832152687 -0.591068644809193 7.40024842556886e-05 miRNATAP -0.204466641805694 1.75118202618028e-10 NA NA NA hsa-miR-30d-5p TPM4 -0.920901858717441 3.50898334321668e-05 -0.591068644809193 7.40024842556886e-05 miRNATAP -0.25241254578749 2.77832690549008e-17 NA NA NA hsa-miR-200a-3p VCAM1 3.14766878548496 1.32850889777422e-21 0.248732748562877 0.395736532722937 miRNAWalker2_validate -0.225066676312216 1.20519950535968e-08 NA NA NA hsa-miR-101-3p VCAN 1.38889039459232 1.96522549511542e-09 0.994352879288806 0.00135386599775065 miRNATAP -0.173885276820375 0.00441086713448918 NA NA NA hsa-miR-103a-3p VCAN 0.538497806383155 1.88134691850591e-05 0.994352879288806 0.00135386599775065 MirTarget;miRNATAP -0.657046852343664 7.39709003998659e-09 NA NA NA hsa-miR-107 VCAN 0.658676029898313 5.11480446318819e-07 0.994352879288806 0.00135386599775065 MirTarget;miRanda;miRNATAP -0.502243536176717 4.19844913146035e-06 NA NA NA hsa-miR-126-5p VCAN 0.851637714492907 0.000391373420568359 0.994352879288806 0.00135386599775065 mirMAP -0.194100122011445 0.001101958670009 NA NA NA hsa-miR-135b-5p VCAN 3.25019233805845 1.95560099639034e-15 0.994352879288806 0.00135386599775065 MirTarget -0.108914648753398 0.00306379017433117 NA NA NA hsa-miR-141-3p VCAN 3.36993755486106 5.42939251147195e-32 0.994352879288806 0.00135386599775065 MirTarget;TargetScan;miRNATAP -0.19259924212035 3.4468588300947e-05 NA NA NA hsa-miR-144-3p VCAN -2.1603497940894 3.64553026877274e-07 0.994352879288806 0.00135386599775065 miRNATAP -0.11314977943482 0.00130233832449493 NA NA NA hsa-miR-16-2-3p VCAN 0.503964803530872 0.0263648405197492 0.994352879288806 0.00135386599775065 mirMAP -0.216470664834532 0.00163331107144263 NA NA NA hsa-miR-181a-5p VCAN -0.375429731222937 0.0562142867129802 0.994352879288806 0.00135386599775065 MirTarget;miRNATAP -0.242866242774393 0.000909443794723729 NA NA NA hsa-miR-186-5p VCAN 0.852175445703945 6.88885738584309e-10 0.994352879288806 0.00135386599775065 MirTarget;miRNATAP -0.516274003737254 4.69949887612721e-07 NA NA NA hsa-miR-200a-3p VCAN 3.14766878548496 1.32850889777422e-21 0.994352879288806 0.00135386599775065 MirTarget;miRNATAP -0.180798180702292 1.98961818666265e-05 NA NA NA hsa-miR-203a-3p VCAN 1.06866854356847 0.00389979689199624 0.994352879288806 0.00135386599775065 MirTarget -0.178020118438008 3.37146614453542e-06 NA NA NA hsa-miR-361-3p VCAN 0.0988926195529967 0.549128728500555 0.994352879288806 0.00135386599775065 miRNATAP -0.405195239033296 3.38182848647453e-06 NA NA NA hsa-miR-429 VCAN 2.3794516574089 1.72813419703734e-13 0.994352879288806 0.00135386599775065 miRanda -0.170837879515301 0.000259129339639526 NA NA NA hsa-miR-664a-3p VCAN 0.443077463053857 0.0214248925850984 0.994352879288806 0.00135386599775065 mirMAP -0.336114786061651 6.1287162968336e-06 NA NA NA hsa-miR-1-3p VEGFA -1.48412019995919 0.000242034342580425 0.230749341603949 0.311300638391058 MirTarget -0.172921089301484 3.76698090411866e-10 24966896 The ectopic expression of miR-1 and miR-145 in NOZ cells significantly inhibited cell viability and colony formation P<0.01 and reduced gene expression of VEGF-A and AXL bladder cancer hsa-miR-101-3p VEGFA 1.38889039459232 1.96522549511542e-09 0.230749341603949 0.311300638391058 miRNAWalker2_validate -0.184546125824104 3.21659312920503e-05 NA NA NA hsa-miR-125a-3p VEGFA -1.04954492275266 2.45974219476832e-06 0.230749341603949 0.311300638391058 miRanda -0.155505773345232 0.000854677712414177 22768249 Ectopic expression of MiR 125a inhibits the proliferation and metastasis of hepatocellular carcinoma by targeting MMP11 and VEGF; Furthermore miR-125a expression was inversely correlated with both MMP11 and VEGF-A expression in HCC tissues; MiR-125a inhibits the proliferation and metastasis of HCC by targeting MMP11 and VEGF-A metastasis liver cancer hsa-miR-133a-3p VEGFA -2.89609207852024 1.71222048144972e-13 0.230749341603949 0.311300638391058 miRNAWalker2_validate -0.104720990536239 5.4001689907379e-05 NA NA NA hsa-miR-140-5p VEGFA 0.669142684153918 0.000335928403032308 0.230749341603949 0.311300638391058 miRNAWalker2_validate;miRTarBase;MirTarget;miRanda;miRNATAP -0.246162039129829 1.79001025551982e-05 26402430 MicroRNA 140 5p inhibits the progression of colorectal cancer by targeting VEGFA; The direct regulation of VEGFA by miR-140-5p was identified using luciferase reporter assay; Integrated analysis identified VEGFA as a direct and functional target gene of miR-140-5p; Silencing VEGFA by small interfering RNA siRNA resembled the phenotype resulting from ectopic miR-140-5p expression while overexpression of VEGFA attenuated the effect of miR-140-5p on CRC cells; Our results suggested a tumor suppressive role of miR-140-5p in CRC tumorigenesis and progression by targeting VEGFA progression;tumorigenesis colorectal cancer hsa-miR-150-5p VEGFA -0.702328520623782 0.0215316651134431 0.230749341603949 0.311300638391058 miRNAWalker2_validate;miRTarBase -0.211938415847961 3.12072029375035e-10 NA NA NA hsa-miR-195-5p VEGFA -1.01577502605386 4.80814718341729e-05 0.230749341603949 0.311300638391058 miRNAWalker2_validate;miRTarBase;MirTarget -0.216253591570711 7.05557590450539e-07 27574422;23468064;26823724 In this study we used a new cationic peptide disulfide cross-linked stearylated polyarginine peptide modified with histidine H3R5 as a reducible vector cell penetrating peptide-modified aptamer ST21 with specific binding to HCC cells to conjugate to peptide H3R5 as the targeting probe miRNA-195 miR195 as a powerful gene drug to inhibit VEGF and fasudil to suppress vasculogenic mimicry by blocking ROCK2 all of which were simultaneously encapsulated in the same nanoparticles;Furthermore we revealed that miR-195 down-regulation resulted in enhanced VEGF levels in the tumor microenvironment which subsequently activated VEGF receptor 2 signaling in endothelial cells and thereby promoted angiogenesis;MiR 195 is a key negative regulator of hepatocellular carcinoma metastasis by targeting FGF2 and VEGFA; Luciferase reporter and ELISA assay prove that hematogenous metastasis related genes including FGF2 and VEGFA are the target genes of miR-195; Taken together our results suggest that miR-195 a tumor suppressor miRNA contributes to the lung metastasis of HCC by negatively regulating FGF2 and VEGFA providing key implications of miR-195 for the therapeutic intervention of HCC ;;metastasis liver cancer;liver cancer;liver cancer hsa-miR-29c-3p VEGFA 1.32354490728858 1.84279305179762e-07 0.230749341603949 0.311300638391058 miRNAWalker2_validate;MirTarget -0.189793475587463 2.81724907347383e-06 NA NA NA hsa-miR-330-3p VEGFA -0.716924999893351 0.000796236278616087 0.230749341603949 0.311300638391058 miRNAWalker2_validate -0.385541553437526 4.9599607016426e-16 NA NA NA hsa-miR-335-5p VEGFA -0.466533891325811 0.0676987038122831 0.230749341603949 0.311300638391058 miRNAWalker2_validate -0.139733266743143 0.00237085343344445 NA NA NA hsa-miR-361-5p VEGFA 0.21454431962475 0.0800957579368424 0.230749341603949 0.311300638391058 miRNAWalker2_validate;miRTarBase;MirTarget;miRanda;miRNATAP -0.311546652005902 0.000341919545726308 NA NA NA hsa-miR-374a-3p VEGFA 1.73882813668241 1.57901646296214e-13 0.230749341603949 0.311300638391058 MirTarget -0.116308302225143 0.0073756212717737 23679262 Our data demonstrated miR-374a to be differentially distributed in breast cancer; VEGF-A and VCAM-1 mRNA had coincident distribution and the distribution of teh respective proteins was uneven and opposite to that for the miR-374a breast cancer hsa-miR-374a-5p VEGFA -0.197027254874826 0.298080902192861 0.230749341603949 0.311300638391058 MirTarget -0.195164100931073 0.0017653451750918 23679262 Our data demonstrated miR-374a to be differentially distributed in breast cancer; VEGF-A and VCAM-1 mRNA had coincident distribution and the distribution of teh respective proteins was uneven and opposite to that for the miR-374a breast cancer hsa-miR-374b-5p VEGFA 0.474691035780475 0.0109217471394203 0.230749341603949 0.311300638391058 MirTarget -0.165654325982956 0.00541935782229369 NA NA NA hsa-miR-378a-3p VEGFA -2.0140903990983 1.146745431034e-18 0.230749341603949 0.311300638391058 miRNAWalker2_validate;miRTarBase -0.188122556602091 1.9053920640873e-05 NA NA NA hsa-miR-1301-3p VIM 0.845987603184611 0.000579808501723616 -1.4959056670806 1.42131990558173e-13 miRNAWalker2_validate -0.244560223025577 1.41654806500915e-10 NA NA NA hsa-miR-17-3p VIM 1.36706429551147 4.60388403547821e-13 -1.4959056670806 1.42131990558173e-13 miRNAWalker2_validate;miRNATAP -0.342422332476067 1.73122781515319e-12 19771525;23418359 The lack of miR-17-3p expression correlated with an increase in vimentin synthesis and tumorigenicity; Stable expression of miR-17-3p in the M12 subline reduced vimentin levels 85% and reverted growth to organized polarized acini in lrECM gels;In contrast the passenger strand miR-17-3p repressed expression of vimentin an intermediate filament with the ability to modulate metabolism and GalNT7 an enzyme that regulates metabolism of liver toxin galactosamine ; prostate cancer;liver cancer hsa-miR-590-3p VIM 0.83851360565783 0.00129224433453587 -1.4959056670806 1.42131990558173e-13 mirMAP -0.130409337499527 0.00299683479112294 NA NA NA hsa-miR-590-5p VIM 2.07441240363458 4.95240551694843e-14 -1.4959056670806 1.42131990558173e-13 PITA;miRanda;miRNATAP -0.152518405420109 0.000270820784522378 NA NA NA hsa-miR-1266-5p WIPF1 -0.289721391624349 0.281500764553995 -0.45486520847116 0.0151127161335464 MirTarget -0.16159697347188 3.81577832000313e-07 NA NA NA hsa-miR-141-3p WIPF1 3.36993755486106 5.42939251147195e-32 -0.45486520847116 0.0151127161335464 MirTarget;TargetScan;miRNATAP -0.225854484940851 1.01642687581395e-16 NA NA NA hsa-miR-182-5p WIPF1 3.21839823004635 5.13049145201115e-39 -0.45486520847116 0.0151127161335464 MirTarget;miRNATAP -0.23662403174471 4.35563549846149e-14 NA NA NA hsa-miR-186-5p WIPF1 0.852175445703945 6.88885738584309e-10 -0.45486520847116 0.0151127161335464 MirTarget;mirMAP;miRNATAP -0.164519751529438 0.0081789918911189 NA NA NA hsa-miR-200a-3p WIPF1 3.14766878548496 1.32850889777422e-21 -0.45486520847116 0.0151127161335464 MirTarget;miRNATAP -0.185906501222371 9.94338915019919e-14 NA NA NA hsa-miR-200b-3p WIPF1 1.55157578247391 4.83790020897188e-09 -0.45486520847116 0.0151127161335464 MirTarget;TargetScan -0.239953611447506 1.40702909197802e-14 NA NA NA hsa-miR-200c-3p WIPF1 0.380533388300368 0.0842181838538353 -0.45486520847116 0.0151127161335464 MirTarget;miRNATAP -0.297912524548714 6.15084275892574e-15 NA NA NA hsa-miR-30b-5p WIPF1 0.358144314839612 0.138026229059594 -0.45486520847116 0.0151127161335464 MirTarget -0.169427002367817 1.86052793235819e-06 NA NA NA hsa-miR-30d-5p WIPF1 -0.920901858717441 3.50898334321668e-05 -0.45486520847116 0.0151127161335464 MirTarget;miRNATAP -0.124788971167489 0.0012033884321409 NA NA NA hsa-miR-324-5p WIPF1 1.06955541886548 5.39722006604758e-05 -0.45486520847116 0.0151127161335464 miRanda -0.159968856385138 6.14851407540346e-07 NA NA NA hsa-miR-429 WIPF1 2.3794516574089 1.72813419703734e-13 -0.45486520847116 0.0151127161335464 MirTarget;PITA;miRanda;miRNATAP -0.212813423755839 8.51859532031125e-15 NA NA NA hsa-miR-664a-3p WIPF1 0.443077463053857 0.0214248925850984 -0.45486520847116 0.0151127161335464 MirTarget -0.16176824088271 0.000311153577603557 NA NA NA hsa-miR-96-5p WIPF1 3.0381097138467 4.40362891630201e-24 -0.45486520847116 0.0151127161335464 miRNATAP -0.247440386718111 5.85261893389705e-16 NA NA NA hsa-miR-126-5p WNT5A 0.851637714492907 0.000391373420568359 -0.372121221213175 0.193057277928512 mirMAP -0.151248062725371 0.00563235728513554 NA NA NA hsa-miR-141-3p WNT5A 3.36993755486106 5.42939251147195e-32 -0.372121221213175 0.193057277928512 TargetScan -0.125793324099707 0.00331852934102782 NA NA NA hsa-miR-142-3p WNT5A 3.98476449801341 1.56256182021111e-35 -0.372121221213175 0.193057277928512 miRanda -0.115944016531076 0.00223771752270671 NA NA NA hsa-miR-155-5p WNT5A 0.813513839059142 0.000608282725633232 -0.372121221213175 0.193057277928512 miRNAWalker2_validate;mirMAP -0.143815735512937 0.00936896648272965 NA NA NA hsa-miR-15b-3p WNT5A 0.804736041893915 0.000400279611457186 -0.372121221213175 0.193057277928512 mirMAP -0.27043439598839 7.90998328619875e-06 NA NA NA hsa-miR-16-2-3p WNT5A 0.503964803530872 0.0263648405197492 -0.372121221213175 0.193057277928512 MirTarget;mirMAP -0.373377688750202 1.87980527171712e-09 NA NA NA hsa-miR-16-5p WNT5A 0.749619098384047 4.11649450706988e-06 -0.372121221213175 0.193057277928512 miRNAWalker2_validate -0.268804385552065 0.000862585179250393 NA NA NA hsa-miR-186-5p WNT5A 0.852175445703945 6.88885738584309e-10 -0.372121221213175 0.193057277928512 miRNAWalker2_validate;mirMAP;miRNATAP -0.417054301807237 9.65966030008268e-06 NA NA NA hsa-miR-29a-5p WNT5A 1.89519956688438 1.03453349363915e-11 -0.372121221213175 0.193057277928512 mirMAP -0.261183965471408 1.91826113480268e-06 NA NA NA hsa-miR-330-5p WNT5A 0.168520831101569 0.336433937906706 -0.372121221213175 0.193057277928512 miRanda -0.274622273940661 0.000275442864491591 NA NA NA hsa-miR-421 WNT5A 0.170525317701774 0.535277026680289 -0.372121221213175 0.193057277928512 miRanda -0.196624128752936 0.000152464264404546 NA NA NA hsa-miR-576-5p WNT5A 1.02693643167056 1.14846964470173e-06 -0.372121221213175 0.193057277928512 mirMAP -0.395707662531266 7.42053392121266e-11 NA NA NA hsa-miR-582-5p WNT5A 1.08286181406653 0.00149040450161757 -0.372121221213175 0.193057277928512 miRNATAP -0.235280095327202 1.35931910686728e-09 NA NA NA hsa-miR-590-3p WNT5A 0.83851360565783 0.00129224433453587 -0.372121221213175 0.193057277928512 miRanda;mirMAP;miRNATAP -0.160395547617788 0.00800150886159335 NA NA NA hsa-miR-7-1-3p WNT5A 2.61364240402652 1.98959237815786e-32 -0.372121221213175 0.193057277928512 mirMAP -0.239522398062042 4.22941459082507e-05 NA NA NA hsa-miR-92a-3p WNT5A -0.136362762339122 0.493412263619364 -0.372121221213175 0.193057277928512 miRNAWalker2_validate -0.355450854560077 6.47407085500391e-08 NA NA NA