miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-200b-3p ABAT -1.29335788099229 0.000268623234305059 -2.16281544019696 3.93403666966165e-18 MirTarget;TargetScan -0.20174121368938 7.2405537664244e-09 NA NA NA hsa-miR-200c-3p ABAT -0.104675615392797 0.716957669484981 -2.16281544019696 3.93403666966165e-18 MirTarget -0.290736669947189 1.24098825512482e-11 NA NA NA hsa-miR-200c-3p ACADSB -0.104675615392797 0.716957669484981 -2.10604065735705 5.36295714659088e-25 mirMAP -0.139586765116836 0.000126927743519834 NA NA NA hsa-miR-200c-3p ACE2 -0.104675615392797 0.716957669484981 -2.26273463135872 3.37120526600485e-06 miRNATAP -0.233455211743432 0.00499327986100553 NA NA NA hsa-miR-200b-3p ACVR1C -1.29335788099229 0.000268623234305059 -2.19871896765337 7.84657232630462e-19 TargetScan -0.183007107086886 1.58925342765656e-07 NA NA NA hsa-miR-200a-5p ADI1 -1.16865179527606 0.00105385823807419 -1.25481623064361 2.50636661784777e-13 MirTarget -0.172298510123787 1.66493819671881e-13 NA NA NA hsa-miR-200c-3p AMFR -0.104675615392797 0.716957669484981 -0.441290037197365 2.60575374342382e-05 miRNATAP -0.127839943461253 1.6552157677427e-13 NA NA NA hsa-miR-200b-3p ANGPTL3 -1.29335788099229 0.000268623234305059 -1.80622645590008 1.54082607373992e-08 TargetScan -0.132311324462219 0.00277049295949422 NA NA NA hsa-miR-200a-3p ANO5 -1.49949292595657 3.18410995256133e-05 -1.2795892530775 0.000554010181638673 mirMAP -0.118003553498129 0.0185562774591544 NA NA NA hsa-miR-200b-3p ANO5 -1.29335788099229 0.000268623234305059 -1.2795892530775 0.000554010181638673 TargetScan -0.132500143706607 0.00907606501868923 NA NA NA hsa-miR-200a-3p AR -1.49949292595657 3.18410995256133e-05 -2.65514434874701 6.79656050811819e-11 mirMAP -0.321533468156768 5.38246996455316e-09 24391862 We identified miR-200 b as a downstream target of androgen receptor and linked its expression to decreased tumorigenicity and metastatic capacity of the prostate cancer cells prostate cancer hsa-miR-200a-5p AR -1.16865179527606 0.00105385823807419 -2.65514434874701 6.79656050811819e-11 miRNATAP -0.334598099933557 1.9612268311013e-09 24391862 We identified miR-200 b as a downstream target of androgen receptor and linked its expression to decreased tumorigenicity and metastatic capacity of the prostate cancer cells prostate cancer hsa-miR-200b-3p ARPP21 -1.29335788099229 0.000268623234305059 -2.2084222061124 6.18332368579158e-08 MirTarget -0.141584643118641 0.0122241635511488 NA NA NA hsa-miR-200c-3p ARPP21 -0.104675615392797 0.716957669484981 -2.2084222061124 6.18332368579158e-08 MirTarget;miRNATAP -0.184676233510735 0.00835110680947251 NA NA NA hsa-miR-200b-3p ASXL3 -1.29335788099229 0.000268623234305059 -2.68929167531641 1.94609933734597e-13 TargetScan -0.166437566300227 0.00116983769517689 NA NA NA hsa-miR-200b-3p ATP11C -1.29335788099229 0.000268623234305059 -1.59600836056671 1.48402272878339e-18 MirTarget;TargetScan -0.153737430018519 1.37853519419002e-09 NA NA NA hsa-miR-200c-3p ATP11C -0.104675615392797 0.716957669484981 -1.59600836056671 1.48402272878339e-18 MirTarget -0.155646122872445 9.06706840797506e-07 NA NA NA hsa-miR-200b-3p BAGE -1.29335788099229 0.000268623234305059 1.24926414369061 0.000880665358020787 MirTarget -0.232345904003915 5.26514827053951e-06 NA NA NA hsa-miR-200c-3p BLCAP -0.104675615392797 0.716957669484981 -0.40718265160047 0.000208400422206877 MirTarget -0.125381078863842 5.24842189547114e-12 NA NA NA hsa-miR-200a-3p C1orf21 -1.49949292595657 3.18410995256133e-05 -0.747097178874137 0.000448927531443378 miRNATAP -0.118207910843335 3.54976088498823e-05 NA NA NA hsa-miR-200a-3p CADM1 -1.49949292595657 3.18410995256133e-05 -0.0259171422650883 0.886286112596045 MirTarget -0.121159716760271 4.62070105512191e-07 NA NA NA hsa-miR-200b-3p CADM1 -1.29335788099229 0.000268623234305059 -0.0259171422650883 0.886286112596045 TargetScan -0.129370028513733 1.04870664138077e-07 NA NA NA hsa-miR-200c-3p CAMK1D -0.104675615392797 0.716957669484981 -0.401457997700563 0.123544927768406 mirMAP -0.111209630947918 0.011548395105414 NA NA NA hsa-miR-200a-3p CDC14B -1.49949292595657 3.18410995256133e-05 -1.18862488716786 6.19212759828214e-11 mirMAP -0.145816275279645 2.99145113535698e-09 NA NA NA hsa-miR-200c-3p CDK6 -0.104675615392797 0.716957669484981 -0.306731100792328 0.220566158555725 mirMAP -0.120071361082355 0.00446253530887124 NA NA NA hsa-miR-200b-3p CECR2 -1.29335788099229 0.000268623234305059 -0.778592534654497 0.0128182957319807 TargetScan -0.298292772668827 7.5387201060145e-13 NA NA NA hsa-miR-200b-3p CFL2 -1.29335788099229 0.000268623234305059 -1.18046432826413 1.44423082204062e-19 MirTarget;TargetScan -0.149316775244117 7.8565894435074e-17 NA NA NA hsa-miR-200c-3p CFL2 -0.104675615392797 0.716957669484981 -1.18046432826413 1.44423082204062e-19 MirTarget;miRNATAP -0.171412623163238 1.72578033665162e-14 23497265 We characterized one of the target genes of miR-200c CFL2 and demonstrated that CFL2 is overexpressed in aggressive breast cancer cell lines and can be significantly down-regulated by exogenous miR-200c breast cancer hsa-miR-200b-3p CHN2 -1.29335788099229 0.000268623234305059 -0.872812918322569 8.35142132938569e-07 MirTarget;TargetScan -0.145394224874016 1.38475830268733e-09 NA NA NA hsa-miR-200c-3p CHN2 -0.104675615392797 0.716957669484981 -0.872812918322569 8.35142132938569e-07 MirTarget -0.170798490612148 1.02238289552572e-08 NA NA NA hsa-miR-200c-3p CNN3 -0.104675615392797 0.716957669484981 0.000263645439876115 0.998162153700641 MirTarget;miRNATAP -0.112405923948634 2.90544260741713e-09 NA NA NA hsa-miR-200a-3p CPLX2 -1.49949292595657 3.18410995256133e-05 5.16430096205473 2.83212867957316e-12 mirMAP -0.380144538956679 0.000185552990185749 NA NA NA hsa-miR-200a-5p CPLX2 -1.16865179527606 0.00105385823807419 5.16430096205473 2.83212867957316e-12 mirMAP -0.363151244160924 0.000428846581586016 NA NA NA hsa-miR-200a-5p CYP4F3 -1.16865179527606 0.00105385823807419 -1.55307662086169 1.07679103282901e-07 MirTarget -0.17157501085559 1.90513226317423e-05 NA NA NA hsa-miR-200a-5p DAB1 -1.16865179527606 0.00105385823807419 -2.13166655168332 3.19240227809803e-09 mirMAP -0.181530351662666 0.000265307295457074 NA NA NA hsa-miR-200a-3p DDI2 -1.49949292595657 3.18410995256133e-05 -1.53096229477393 2.81259482387215e-06 mirMAP -0.157323394480694 0.000381237692792413 NA NA NA hsa-miR-200a-3p DIO2 -1.49949292595657 3.18410995256133e-05 1.74798259848111 3.86024401348235e-05 miRNATAP -0.16140341616352 0.00503256393310407 NA NA NA hsa-miR-200b-3p DMD -1.29335788099229 0.000268623234305059 -1.6618166260325 2.70344741582688e-17 TargetScan -0.106140394528467 0.000129802265969075 NA NA NA hsa-miR-200c-3p DMD -0.104675615392797 0.716957669484981 -1.6618166260325 2.70344741582688e-17 miRNATAP -0.129811245863098 0.00016019998059967 NA NA NA hsa-miR-200c-3p DNAJB9 -0.104675615392797 0.716957669484981 -0.631181264981697 8.66249196538849e-07 miRNATAP -0.121113894283605 2.03216372027438e-08 NA NA NA hsa-miR-200c-3p DUSP1 -0.104675615392797 0.716957669484981 -2.0215708216874 6.14519109294513e-23 MirTarget;miRNATAP -0.103798077898348 0.00452391050034368 NA NA NA hsa-miR-200a-3p DYNC1I1 -1.49949292595657 3.18410995256133e-05 1.66864494169359 1.46552904583527e-05 MirTarget -0.273821501304747 1.1122846089688e-07 NA NA NA hsa-miR-200b-3p DYNC1I1 -1.29335788099229 0.000268623234305059 1.66864494169359 1.46552904583527e-05 MirTarget -0.237798564116032 6.03917207657237e-06 NA NA NA hsa-miR-200c-3p DYNC1I1 -0.104675615392797 0.716957669484981 1.66864494169359 1.46552904583527e-05 MirTarget -0.160656798224435 0.0144886501147065 NA NA NA hsa-miR-200b-3p ELL2 -1.29335788099229 0.000268623234305059 -0.765981836031949 3.63519932659754e-07 MirTarget;TargetScan -0.110693970089153 6.71351297259549e-08 NA NA NA hsa-miR-200c-3p ELL2 -0.104675615392797 0.716957669484981 -0.765981836031949 3.63519932659754e-07 MirTarget -0.155000859348722 8.85360169350686e-10 NA NA NA hsa-miR-200b-3p ENPEP -1.29335788099229 0.000268623234305059 -1.54698393392775 7.79743337627367e-13 mirMAP -0.17764289335005 2.37329005434053e-09 NA NA NA hsa-miR-200c-3p ENTPD5 -0.104675615392797 0.716957669484981 -1.12067424960293 7.40905747722605e-09 MirTarget -0.110496842290657 0.00088812396303987 NA NA NA hsa-miR-200b-3p ESM1 -1.29335788099229 0.000268623234305059 4.20711739039803 3.17446765555696e-44 MirTarget -0.260139772983509 8.47077815707931e-09 NA NA NA hsa-miR-200a-3p FAM133A -1.49949292595657 3.18410995256133e-05 1.83787122276161 0.00087266704058653 mirMAP -0.440503439879882 1.8700527120213e-09 NA NA NA hsa-miR-200a-3p FAM169A -1.49949292595657 3.18410995256133e-05 0.365458857393713 0.13290757956596 mirMAP -0.18699394719087 6.00571957027913e-09 NA NA NA hsa-miR-200b-3p FGF12 -1.29335788099229 0.000268623234305059 1.12701565396445 0.000125070474588253 TargetScan -0.167486025000735 2.91497216782912e-05 NA NA NA hsa-miR-200b-3p FGF2 -1.29335788099229 0.000268623234305059 -1.08625533231299 0.000324809942833161 mirMAP -0.168899172593471 4.11351056555817e-05 NA NA NA hsa-miR-200c-3p FGF2 -0.104675615392797 0.716957669484981 -1.08625533231299 0.000324809942833161 mirMAP -0.156084549253076 0.00233819769179705 NA NA NA hsa-miR-200a-5p FITM2 -1.16865179527606 0.00105385823807419 0.374342316185036 0.00294098826341785 mirMAP -0.140502394344283 1.7801182928808e-17 NA NA NA hsa-miR-200b-3p FSTL4 -1.29335788099229 0.000268623234305059 3.14060414756178 7.65786604995946e-16 TargetScan -0.115440141477325 0.0364220478652801 NA NA NA hsa-miR-200b-3p G6PC -1.29335788099229 0.000268623234305059 -1.88488951906391 2.56486640480655e-07 MirTarget;TargetScan -0.13399064419035 0.00804554754882444 NA NA NA hsa-miR-200c-3p G6PC -0.104675615392797 0.716957669484981 -1.88488951906391 2.56486640480655e-07 MirTarget -0.244076555440378 9.08865751877016e-05 NA NA NA hsa-miR-200a-3p GFRA1 -1.49949292595657 3.18410995256133e-05 -2.5486406119615 2.43457108723549e-08 mirMAP -0.241264114686487 0.000103913797093121 NA NA NA hsa-miR-200a-5p GFRA1 -1.16865179527606 0.00105385823807419 -2.5486406119615 2.43457108723549e-08 mirMAP -0.271515456995589 1.55237050472757e-05 NA NA NA hsa-miR-200b-3p GFRA1 -1.29335788099229 0.000268623234305059 -2.5486406119615 2.43457108723549e-08 mirMAP -0.240159266056063 0.000139472801674815 NA NA NA hsa-miR-200c-3p GFRA1 -0.104675615392797 0.716957669484981 -2.5486406119615 2.43457108723549e-08 mirMAP -0.317347216398356 4.79666796888433e-05 NA NA NA hsa-miR-200a-3p GFRA2 -1.49949292595657 3.18410995256133e-05 -1.04393868358313 2.62726967509854e-06 mirMAP -0.114490676468883 0.000139840605597766 NA NA NA hsa-miR-200a-3p GLRX -1.49949292595657 3.18410995256133e-05 -0.975673886303721 2.13364253566235e-08 MirTarget;miRNATAP -0.146239492141314 3.72009323128896e-10 NA NA NA hsa-miR-200b-3p GLRX -1.29335788099229 0.000268623234305059 -0.975673886303721 2.13364253566235e-08 MirTarget -0.167821284232496 9.31286846097661e-13 NA NA NA hsa-miR-200c-3p GLRX -0.104675615392797 0.716957669484981 -0.975673886303721 2.13364253566235e-08 MirTarget -0.158035060841168 8.64442020258777e-08 NA NA NA hsa-miR-200a-5p GLUL -1.16865179527606 0.00105385823807419 0.444046234271983 0.126185814713881 MirTarget -0.199482451644006 3.29561067731542e-07 NA NA NA hsa-miR-200a-3p GNE -1.49949292595657 3.18410995256133e-05 -1.82350791069008 3.50187061744317e-25 MirTarget -0.123830487706671 6.23692354872325e-07 NA NA NA hsa-miR-200c-3p GOT1 -0.104675615392797 0.716957669484981 -1.38071166880519 5.71668186526466e-13 MirTarget -0.121231536481427 0.00025725050522838 NA NA NA hsa-miR-200a-3p GPAM -1.49949292595657 3.18410995256133e-05 -0.472844151955403 0.0637965177079971 MirTarget -0.147729150383121 1.43328969310491e-05 NA NA NA hsa-miR-200b-3p GPR146 -1.29335788099229 0.000268623234305059 -1.57917525184505 3.50197927484952e-23 TargetScan -0.105948270896817 3.12726023736016e-06 NA NA NA hsa-miR-200c-3p GPR146 -0.104675615392797 0.716957669484981 -1.57917525184505 3.50197927484952e-23 miRNATAP -0.157209016465892 1.98527598446146e-08 NA NA NA hsa-miR-200b-3p GPR158 -1.29335788099229 0.000268623234305059 2.23744757647133 4.79988747049009e-07 TargetScan -0.471856946133946 1.93763843849848e-15 NA NA NA hsa-miR-200c-3p GPR158 -0.104675615392797 0.716957669484981 2.23744757647133 4.79988747049009e-07 miRNATAP -0.32186782191884 2.06789995693162e-05 NA NA NA hsa-miR-200c-3p GPRASP2 -0.104675615392797 0.716957669484981 -0.64634103964299 3.73116290903046e-06 MirTarget -0.171027713956147 1.55743255279205e-13 NA NA NA hsa-miR-200b-3p GREM2 -1.29335788099229 0.000268623234305059 -3.6542600937751 6.32290251963313e-12 TargetScan -0.331011384185559 7.34416224133068e-06 NA NA NA hsa-miR-200b-3p HLF -1.29335788099229 0.000268623234305059 -1.56359740264692 3.39928227602253e-08 MirTarget;TargetScan -0.180495138177449 3.4860282160296e-06 NA NA NA hsa-miR-200c-3p HLF -0.104675615392797 0.716957669484981 -1.56359740264692 3.39928227602253e-08 MirTarget;miRNATAP -0.342928698142652 4.3962980799122e-13 NA NA NA hsa-miR-200c-3p ICK -0.104675615392797 0.716957669484981 0.39119996904083 0.0104331872491703 MirTarget;miRNATAP -0.103118005762506 5.96524826667381e-05 NA NA NA hsa-miR-200a-3p IKBKG -1.49949292595657 3.18410995256133e-05 0.660366120199928 1.71867865546723e-06 mirMAP -0.100439586597671 5.62621816828972e-08 NA NA NA hsa-miR-200a-3p IL6R -1.49949292595657 3.18410995256133e-05 -0.197357669964791 0.382548993653367 MirTarget -0.159850426034774 9.36193333495953e-08 NA NA NA hsa-miR-200c-3p IMMP2L -0.104675615392797 0.716957669484981 0.0935961239768521 0.501956165404163 MirTarget -0.186787287316971 1.61158351776187e-16 NA NA NA hsa-miR-200b-3p IRS1 -1.29335788099229 0.000268623234305059 -0.221383948238947 0.137544848662312 TargetScan -0.13655932431926 5.29991549499767e-12 26314828 Taken together our results suggest that miR-200 may activate AKT in lung adenocarcinoma cells through a FOG2-independent mechanism involving IRS-1 lung cancer hsa-miR-200c-3p IRS1 -0.104675615392797 0.716957669484981 -0.221383948238947 0.137544848662312 miRNATAP -0.185915259944595 2.49647913870381e-14 NA NA NA hsa-miR-200b-3p ITPR2 -1.29335788099229 0.000268623234305059 -0.68468127740298 4.90072911451155e-05 MirTarget -0.131779911059464 7.30054033937174e-09 NA NA NA hsa-miR-200c-3p ITPR2 -0.104675615392797 0.716957669484981 -0.68468127740298 4.90072911451155e-05 MirTarget -0.200197308843578 7.87036360713507e-13 NA NA NA hsa-miR-200b-3p JAKMIP2 -1.29335788099229 0.000268623234305059 -0.850250373285728 0.00348445584858937 TargetScan -0.216248236029325 3.58052047131474e-08 NA NA NA hsa-miR-200b-3p KCNB1 -1.29335788099229 0.000268623234305059 -1.36493235155488 0.00106428111512555 TargetScan -0.298946831080527 1.15132655044876e-07 NA NA NA hsa-miR-200c-3p KDR -0.104675615392797 0.716957669484981 -0.806222400057247 9.66990863598643e-06 miRNATAP -0.116520342266903 0.00016541089831424 24205206 MiR 200c increases the radiosensitivity of non small cell lung cancer cell line A549 by targeting VEGF VEGFR2 pathway; MiR-200c at the nexus of epithelial-mesenchymal transition EMT is predicted to target VEGFR2; The purpose of this study is to test the hypothesis that regulation of VEGFR2 pathway by miR-200c could modulate the radiosensitivity of cancer cells; Bioinformatic analysis luciferase reporter assays and biochemical assays were carried out to validate VEGFR2 as a direct target of miR-200c; We identified VEGFR2 as a novel target of miR-200c lung squamous cell cancer hsa-miR-200a-5p KLF9 -1.16865179527606 0.00105385823807419 -1.35905833834713 1.22932810880238e-12 MirTarget;miRNATAP -0.170485245422285 7.99418140224418e-11 NA NA NA hsa-miR-200b-3p KLF9 -1.29335788099229 0.000268623234305059 -1.35905833834713 1.22932810880238e-12 TargetScan -0.159486622143421 1.39817190596469e-09 NA NA NA hsa-miR-200c-3p KLF9 -0.104675615392797 0.716957669484981 -1.35905833834713 1.22932810880238e-12 miRNAWalker2_validate;miRTarBase;miRNATAP -0.242684787366071 5.42773268042667e-14 NA NA NA hsa-miR-200c-3p KLHDC1 -0.104675615392797 0.716957669484981 -0.601082421430644 0.000687003874530233 MirTarget -0.107580192951817 0.000326052877642416 NA NA NA hsa-miR-200b-3p LGSN -1.29335788099229 0.000268623234305059 -2.52633123363191 1.49953406371445e-10 MirTarget -0.246560878031778 6.17521108660755e-06 NA NA NA hsa-miR-200c-3p LGSN -0.104675615392797 0.716957669484981 -2.52633123363191 1.49953406371445e-10 MirTarget -0.337428729253422 5.61108506023632e-07 NA NA NA hsa-miR-200a-3p LIN28B -1.49949292595657 3.18410995256133e-05 2.26854994708754 4.69141976850235e-05 miRNATAP -0.25767264578006 0.000624394188215696 NA NA NA hsa-miR-200a-3p LMLN -1.49949292595657 3.18410995256133e-05 -0.166069500007594 0.301560342444305 mirMAP -0.10170139201847 1.91973938931081e-06 NA NA NA hsa-miR-200b-3p LPIN1 -1.29335788099229 0.000268623234305059 -0.135731511477539 0.370548383872963 MirTarget;TargetScan -0.155886532068597 5.66622502011737e-15 NA NA NA hsa-miR-200b-3p LRP1B -1.29335788099229 0.000268623234305059 -1.66988275957729 9.68113918882022e-05 MirTarget;TargetScan -0.144543468981676 0.0140409074719293 NA NA NA hsa-miR-200b-3p LRP4 -1.29335788099229 0.000268623234305059 0.524814974673234 0.0714526289696762 MirTarget;TargetScan -0.120353060831476 0.00239023799334666 NA NA NA hsa-miR-200b-3p MAGEC2 -1.29335788099229 0.000268623234305059 3.47248606470706 1.02062430360877e-07 MirTarget -0.591996815122928 1.98776995395788e-11 NA NA NA hsa-miR-200c-3p MAGEC2 -0.104675615392797 0.716957669484981 3.47248606470706 1.02062430360877e-07 MirTarget -0.283595767501711 0.0113033744872984 NA NA NA hsa-miR-200a-3p MAP2 -1.49949292595657 3.18410995256133e-05 1.05154488256307 5.66592949255683e-05 miRNATAP -0.106182104744404 0.00265415940981909 NA NA NA hsa-miR-200b-3p MAP2 -1.29335788099229 0.000268623234305059 1.05154488256307 5.66592949255683e-05 MirTarget;TargetScan -0.122160976674775 0.000637229121761702 NA NA NA hsa-miR-200a-3p MFAP3L -1.49949292595657 3.18410995256133e-05 -2.99511248620354 4.97173912475439e-19 MirTarget -0.258155599277689 2.9942972305985e-08 NA NA NA hsa-miR-200a-5p MFAP3L -1.16865179527606 0.00105385823807419 -2.99511248620354 4.97173912475439e-19 MirTarget -0.29977293380653 1.65107306944772e-10 NA NA NA hsa-miR-200b-3p MOCS1 -1.29335788099229 0.000268623234305059 -0.555657989620138 3.09140540393222e-05 TargetScan -0.132562233333979 8.95753884064809e-14 NA NA NA hsa-miR-200b-3p MPDZ -1.29335788099229 0.000268623234305059 -1.65744377586076 1.88159400278804e-15 MirTarget -0.227861174311719 1.1617389292144e-15 NA NA NA hsa-miR-200c-3p MPDZ -0.104675615392797 0.716957669484981 -1.65744377586076 1.88159400278804e-15 MirTarget -0.226310877930602 2.51326575009299e-10 NA NA NA hsa-miR-200a-3p MYRIP -1.49949292595657 3.18410995256133e-05 -1.62618818441801 1.98171502701597e-05 MirTarget -0.361588643943789 6.88982841748473e-13 NA NA NA hsa-miR-200c-3p NAP1L5 -0.104675615392797 0.716957669484981 -1.29692509941602 3.32250714880114e-12 MirTarget;miRNATAP -0.12923444988944 5.75166699515856e-05 NA NA NA hsa-miR-200c-3p NDUFA5 -0.104675615392797 0.716957669484981 -0.406708643172571 3.49036349124771e-05 mirMAP -0.113166980703701 3.61704130382203e-12 NA NA NA hsa-miR-200a-3p NFIA -1.49949292595657 3.18410995256133e-05 -0.924685216157224 2.60745966247054e-13 miRNATAP -0.107249027311717 3.98033596728848e-10 NA NA NA hsa-miR-200a-5p NFIA -1.16865179527606 0.00105385823807419 -0.924685216157224 2.60745966247054e-13 MirTarget;miRNATAP -0.118622517676743 6.81897213917066e-12 NA NA NA hsa-miR-200b-3p NFIA -1.29335788099229 0.000268623234305059 -0.924685216157224 2.60745966247054e-13 MirTarget;TargetScan -0.112861139473795 7.83308699959146e-11 NA NA NA hsa-miR-200c-3p NFIA -0.104675615392797 0.716957669484981 -0.924685216157224 2.60745966247054e-13 MirTarget;miRNATAP -0.155153389266155 3.96283375328525e-13 NA NA NA hsa-miR-200b-3p NKD1 -1.29335788099229 0.000268623234305059 0.620599204750343 0.186026311634854 TargetScan -0.177575800556816 0.00545052296927983 NA NA NA hsa-miR-200b-3p NLGN4X -1.29335788099229 0.000268623234305059 -1.2760138670071 0.000397120705032193 TargetScan -0.1228283308022 0.0129166425701295 NA NA NA hsa-miR-200c-3p NRG1 -0.104675615392797 0.716957669484981 -3.95953255287574 8.76353628841238e-16 miRNATAP -0.175730636684176 0.0419989325048598 NA NA NA hsa-miR-200a-3p NUDT12 -1.49949292595657 3.18410995256133e-05 -0.913123810950026 1.69707017169193e-05 MirTarget -0.137753324784094 1.34884075931471e-06 NA NA NA hsa-miR-200a-3p NUDT16 -1.49949292595657 3.18410995256133e-05 -0.306472623503673 0.00173007556301039 mirMAP -0.110899590669214 1.54302920988239e-18 NA NA NA hsa-miR-200b-3p ONECUT2 -1.29335788099229 0.000268623234305059 0.120890541524141 0.551384233388767 TargetScan;mirMAP -0.108717692664238 7.51149457509459e-05 NA NA NA hsa-miR-200c-3p ONECUT2 -0.104675615392797 0.716957669484981 0.120890541524141 0.551384233388767 mirMAP -0.105449713985505 0.002023575427188 NA NA NA hsa-miR-200b-3p PALM2 -1.29335788099229 0.000268623234305059 -2.07895743328401 4.60304002325711e-20 TargetScan -0.143691140873073 7.76835901831723e-06 NA NA NA hsa-miR-200a-5p PDE4DIP -1.16865179527606 0.00105385823807419 -0.268391772056326 0.0604161803169821 mirMAP -0.112232557362712 4.40079189431084e-09 NA NA NA hsa-miR-200b-3p PI4K2B -1.29335788099229 0.000268623234305059 -0.759829344931532 1.35039006281556e-09 MirTarget;TargetScan -0.105489468194992 6.51992165814565e-10 NA NA NA hsa-miR-200c-3p PI4K2B -0.104675615392797 0.716957669484981 -0.759829344931532 1.35039006281556e-09 MirTarget -0.141882211872434 1.68772770308869e-11 NA NA NA hsa-miR-200c-3p PIK3R1 -0.104675615392797 0.716957669484981 -0.891953424131491 1.38465728969785e-08 mirMAP -0.105107802462856 9.06963579759966e-05 NA NA NA hsa-miR-200b-3p PPARA -1.29335788099229 0.000268623234305059 -0.607171871846345 3.30592576448713e-05 MirTarget -0.130736116610999 2.77406374155859e-11 NA NA NA hsa-miR-200c-3p PPARA -0.104675615392797 0.716957669484981 -0.607171871846345 3.30592576448713e-05 MirTarget -0.13353258911724 5.37830146604008e-08 NA NA NA hsa-miR-200c-3p PPARGC1A -0.104675615392797 0.716957669484981 -1.91181447721978 1.53762022606371e-08 mirMAP -0.201515030015097 0.000501716311429974 NA NA NA hsa-miR-200a-3p PPARGC1B -1.49949292595657 3.18410995256133e-05 -0.171170839113116 0.38344943912292 mirMAP -0.149441983635569 8.35532163126598e-09 NA NA NA hsa-miR-200a-5p PPARGC1B -1.16865179527606 0.00105385823807419 -0.171170839113116 0.38344943912292 mirMAP -0.141128192369587 8.48720148575123e-08 NA NA NA hsa-miR-200b-3p PPARGC1B -1.29335788099229 0.000268623234305059 -0.171170839113116 0.38344943912292 mirMAP -0.153401011196948 5.36600431214157e-09 NA NA NA hsa-miR-200c-3p PPARGC1B -0.104675615392797 0.716957669484981 -0.171170839113116 0.38344943912292 mirMAP -0.105247236274711 0.0014520115986668 NA NA NA hsa-miR-200a-3p PPM1E -1.49949292595657 3.18410995256133e-05 -0.360513887000119 0.296794279955595 MirTarget;miRNATAP -0.141186219993018 0.00230931366966435 NA NA NA hsa-miR-200a-5p PPM1E -1.16865179527606 0.00105385823807419 -0.360513887000119 0.296794279955595 MirTarget -0.160679372538241 0.000606884679173118 NA NA NA hsa-miR-200b-3p PPM1E -1.29335788099229 0.000268623234305059 -0.360513887000119 0.296794279955595 MirTarget -0.169388428749446 0.000301704267109763 NA NA NA hsa-miR-200a-3p PPM1L -1.49949292595657 3.18410995256133e-05 -0.358173274286561 0.0774099414261059 MirTarget -0.116210268724851 1.75623491180934e-05 NA NA NA hsa-miR-200b-3p PSD3 -1.29335788099229 0.000268623234305059 -1.20252145080477 1.19868322011977e-09 MirTarget;mirMAP -0.100238016254215 0.000251457076486613 NA NA NA hsa-miR-200c-3p PSD3 -0.104675615392797 0.716957669484981 -1.20252145080477 1.19868322011977e-09 MirTarget;mirMAP;miRNATAP -0.101536339494013 0.00285091029223855 NA NA NA hsa-miR-200a-3p RAB3C -1.49949292595657 3.18410995256133e-05 0.178372730945339 0.696406798542448 mirMAP -0.158941486119135 0.00959740004819449 NA NA NA hsa-miR-200c-3p RANBP10 -0.104675615392797 0.716957669484981 -0.164752457150059 0.142653302199525 MirTarget;miRNATAP -0.141751104295368 1.10565695265137e-14 NA NA NA hsa-miR-200b-3p RBM20 -1.29335788099229 0.000268623234305059 0.805630250198087 0.00223301201387115 MirTarget;TargetScan -0.143981728406133 5.90506666788481e-05 NA NA NA hsa-miR-200b-3p RNASEL -1.29335788099229 0.000268623234305059 -0.297651918005738 0.0884553326716658 MirTarget -0.127016135741778 6.29310626569916e-08 NA NA NA hsa-miR-200c-3p RNASEL -0.104675615392797 0.716957669484981 -0.297651918005738 0.0884553326716658 MirTarget -0.121369010718483 3.46604808345165e-05 NA NA NA hsa-miR-200a-3p RNF217 -1.49949292595657 3.18410995256133e-05 -0.867667786029885 3.07330761625567e-05 mirMAP -0.163510567882928 3.79334006886486e-09 NA NA NA hsa-miR-200a-5p RNF217 -1.16865179527606 0.00105385823807419 -0.867667786029885 3.07330761625567e-05 mirMAP -0.160045338578155 1.30106086788206e-08 NA NA NA hsa-miR-200a-5p RORA -1.16865179527606 0.00105385823807419 -1.18591701647076 1.08163415927424e-11 MirTarget;miRNATAP -0.101322856527578 2.84100326968821e-05 NA NA NA hsa-miR-200a-3p RSPO2 -1.49949292595657 3.18410995256133e-05 -1.47503442551075 0.000466618278395286 MirTarget -0.136720614302119 0.0165045290083387 NA NA NA hsa-miR-200b-3p SAR1B -1.29335788099229 0.000268623234305059 -0.602691569549908 4.60715859176311e-06 TargetScan -0.15544820676368 2.83442808567305e-19 NA NA NA hsa-miR-200a-3p SCN4A -1.49949292595657 3.18410995256133e-05 1.81438097558751 8.81770750257501e-15 mirMAP -0.177691837908934 2.98123669681623e-08 NA NA NA hsa-miR-200a-3p SCP2 -1.49949292595657 3.18410995256133e-05 -1.70380219576361 1.44289672057111e-21 miRNATAP -0.138734313945785 2.53079338056179e-08 NA NA NA hsa-miR-200c-3p SDC2 -0.104675615392797 0.716957669484981 -0.03087902282995 0.814769949243076 miRNATAP -0.109227562544359 6.52546401744091e-07 NA NA NA hsa-miR-200c-3p SEC23A -0.104675615392797 0.716957669484981 -0.751058909791861 9.54115837173632e-12 MirTarget;miRNATAP -0.111866598580091 2.36731885416893e-09 21593139 A computational analysis predicted the 3'-UTR of the SEC23A gene as a potential target for both miR-375 and miR-200c; Here we show that the 3'-UTR of SEC23A mRNA is indeed a target for miR-375 and miR-200c and that both miRNAs downregulate Sec23A protein expression when ectopically expressed in human 293T cells; In primary samples of CaP we found a direct correlation between reduction of SEC23A mRNA and overexpression of miR-375 but not of miR-200c prostate cancer hsa-miR-200b-3p SERPINC1 -1.29335788099229 0.000268623234305059 -1.63659372569249 4.45044096391072e-05 TargetScan -0.348266478245226 1.09051682707373e-10 NA NA NA hsa-miR-200a-5p SESN3 -1.16865179527606 0.00105385823807419 -0.821541570789657 0.00383798636487833 mirMAP -0.137250175576184 0.00038794439690191 NA NA NA hsa-miR-200b-3p SESN3 -1.29335788099229 0.000268623234305059 -0.821541570789657 0.00383798636487833 MirTarget;TargetScan -0.137355288143689 0.000388778971985253 NA NA NA hsa-miR-200b-3p SETD7 -1.29335788099229 0.000268623234305059 -0.645690628283917 3.04188071973992e-07 TargetScan -0.103544205238595 1.35669189790382e-09 NA NA NA hsa-miR-200b-3p SFXN1 -1.29335788099229 0.000268623234305059 -0.990318290801911 5.86324585320089e-17 TargetScan -0.107314279203532 5.84613600761995e-11 NA NA NA hsa-miR-200b-3p SHROOM1 -1.29335788099229 0.000268623234305059 0.32396056314659 0.0272849426325293 MirTarget -0.10088315079118 3.35108736339512e-07 NA NA NA hsa-miR-200c-3p SHROOM1 -0.104675615392797 0.716957669484981 0.32396056314659 0.0272849426325293 MirTarget;miRNATAP -0.102440379575779 3.20930046673925e-05 NA NA NA hsa-miR-200a-3p SIM1 -1.49949292595657 3.18410995256133e-05 0.194554365184953 0.610702960280356 MirTarget -0.118630842879356 0.0208574952168558 NA NA NA hsa-miR-200b-3p SLC16A10 -1.29335788099229 0.000268623234305059 -1.40592334895919 3.67016779027723e-07 TargetScan -0.14845701489287 9.36286275540471e-05 NA NA NA hsa-miR-200b-3p SLC16A12 -1.29335788099229 0.000268623234305059 -0.582701560249782 0.124002938826254 mirMAP -0.147338118212357 0.00428331444430191 NA NA NA hsa-miR-200c-3p SLC16A12 -0.104675615392797 0.716957669484981 -0.582701560249782 0.124002938826254 mirMAP;miRNATAP -0.233656455729576 0.000246455359683744 NA NA NA hsa-miR-200b-3p SLC16A2 -1.29335788099229 0.000268623234305059 -1.72029553621989 7.69802544223928e-14 TargetScan -0.179781579834016 1.69676378169003e-08 NA NA NA hsa-miR-200c-3p SLC16A2 -0.104675615392797 0.716957669484981 -1.72029553621989 7.69802544223928e-14 miRNATAP -0.282104865235312 4.96162677864692e-13 NA NA NA hsa-miR-200b-3p SLC1A2 -1.29335788099229 0.000268623234305059 -2.05184743338733 5.07102901300161e-06 MirTarget;TargetScan -0.341320883974919 2.29198382596904e-08 NA NA NA hsa-miR-200c-3p SLC1A2 -0.104675615392797 0.716957669484981 -2.05184743338733 5.07102901300161e-06 MirTarget;miRNATAP -0.525598818737795 2.27806764641753e-12 NA NA NA hsa-miR-200c-3p SLC23A2 -0.104675615392797 0.716957669484981 -0.584703803315866 0.0010236404080005 miRNATAP -0.177741914487411 2.12172713714768e-09 NA NA NA hsa-miR-200a-3p SLC25A42 -1.49949292595657 3.18410995256133e-05 -0.835095118088987 2.88686387157856e-06 mirMAP -0.138153593449999 7.06832604624988e-09 NA NA NA hsa-miR-200b-3p SLC35B4 -1.29335788099229 0.000268623234305059 0.122330329859142 0.249678861953627 MirTarget -0.100803428093195 7.26717459720261e-13 NA NA NA hsa-miR-200c-3p SLC35B4 -0.104675615392797 0.716957669484981 0.122330329859142 0.249678861953627 MirTarget -0.1237440745183 1.24535328492867e-12 NA NA NA hsa-miR-200c-3p SLC38A2 -0.104675615392797 0.716957669484981 -1.71612155888541 1.01671436925464e-27 miRNATAP -0.117909517882505 2.95033782336302e-05 NA NA NA hsa-miR-200b-3p SLC38A4 -1.29335788099229 0.000268623234305059 -2.20440604206587 1.47282964888718e-12 TargetScan -0.20010276753016 3.76847156465473e-06 NA NA NA hsa-miR-200c-3p SLC38A4 -0.104675615392797 0.716957669484981 -2.20440604206587 1.47282964888718e-12 miRNATAP -0.15731337614072 0.00361564826389016 NA NA NA hsa-miR-200b-3p SLC39A8 -1.29335788099229 0.000268623234305059 -1.07296538145162 1.26351600102301e-11 MirTarget -0.174563670030204 2.9591580633491e-16 NA NA NA hsa-miR-200c-3p SLC39A8 -0.104675615392797 0.716957669484981 -1.07296538145162 1.26351600102301e-11 MirTarget -0.19693689786095 1.50459520504562e-13 NA NA NA hsa-miR-200c-3p SLC4A4 -0.104675615392797 0.716957669484981 -2.23317622565422 7.81779722860372e-13 mirMAP -0.172428710570881 0.00143195378732076 NA NA NA hsa-miR-200b-3p SLC6A1 -1.29335788099229 0.000268623234305059 -1.17614916548093 6.73017890737053e-05 MirTarget;TargetScan -0.170203299621282 2.36593486388763e-05 NA NA NA hsa-miR-200c-3p SLC6A1 -0.104675615392797 0.716957669484981 -1.17614916548093 6.73017890737053e-05 MirTarget;miRNATAP -0.207907514634346 3.12407384433956e-05 NA NA NA hsa-miR-200a-5p SLC7A11 -1.16865179527606 0.00105385823807419 3.47167805920945 1.56674476751757e-19 mirMAP -0.156971588330154 0.00413090981814643 NA NA NA hsa-miR-200a-5p SLCO1A2 -1.16865179527606 0.00105385823807419 -1.53455538662681 4.79106917340698e-05 MirTarget -0.250524640951078 1.04080856850899e-06 NA NA NA hsa-miR-200b-3p SNAI2 -1.29335788099229 0.000268623234305059 0.384447886331124 0.102927984369101 TargetScan -0.113933336744523 0.000370832757095312 NA NA NA hsa-miR-200c-3p SNAI2 -0.104675615392797 0.716957669484981 0.384447886331124 0.102927984369101 miRNATAP -0.13296318092996 0.000812112160068585 NA NA NA hsa-miR-200a-3p SQSTM1 -1.49949292595657 3.18410995256133e-05 0.814011499476504 1.06852369530173e-06 mirMAP -0.128048381919287 9.91404882929475e-09 NA NA NA hsa-miR-200a-3p ST3GAL3 -1.49949292595657 3.18410995256133e-05 0.0452353339861049 0.689737393298641 MirTarget;miRNATAP -0.112675547131175 1.85345328818086e-14 NA NA NA hsa-miR-200b-3p TFPI -1.29335788099229 0.000268623234305059 -0.692334589210751 0.00101475366143222 MirTarget -0.137561883224302 1.45325909281821e-06 NA NA NA hsa-miR-200c-3p TFPI -0.104675615392797 0.716957669484981 -0.692334589210751 0.00101475366143222 MirTarget -0.130263242015182 0.000253535025481358 NA NA NA hsa-miR-200b-3p TIGD2 -1.29335788099229 0.000268623234305059 -0.936569715237616 1.5979209828487e-07 TargetScan -0.117934255446 1.41670428554781e-06 NA NA NA hsa-miR-200b-3p TMEM110 -1.29335788099229 0.000268623234305059 -0.263748642092995 0.0243287997140745 mirMAP -0.108678822119125 2.80204284562316e-12 NA NA NA hsa-miR-200b-3p TMEM14A -1.29335788099229 0.000268623234305059 0.301048605099102 0.0227620000019524 TargetScan -0.120966729387528 5.96904427325937e-12 NA NA NA hsa-miR-200a-3p TMEM170B -1.49949292595657 3.18410995256133e-05 -0.28665834823882 0.06540862544437 MirTarget;miRNATAP -0.126241127816699 7.5460843285146e-10 NA NA NA hsa-miR-200b-3p TMEM170B -1.29335788099229 0.000268623234305059 -0.28665834823882 0.06540862544437 TargetScan -0.129810350134971 4.22884603899517e-10 NA NA NA hsa-miR-200a-3p TMEM56 -1.49949292595657 3.18410995256133e-05 -1.75634225549522 4.44536598470124e-19 MirTarget;miRNATAP -0.120585318693472 1.12021228172798e-05 NA NA NA hsa-miR-200b-3p TMEM56 -1.29335788099229 0.000268623234305059 -1.75634225549522 4.44536598470124e-19 MirTarget -0.131830736413457 2.0823938239557e-06 NA NA NA hsa-miR-200c-3p TMEM56 -0.104675615392797 0.716957669484981 -1.75634225549522 4.44536598470124e-19 MirTarget -0.176737435129661 2.68897677812851e-07 NA NA NA hsa-miR-200c-3p TOB1 -0.104675615392797 0.716957669484981 -0.431174885164615 0.0092147974081398 miRNATAP -0.119590728905381 1.71601726095915e-05 NA NA NA hsa-miR-200b-3p TP73 -1.29335788099229 0.000268623234305059 3.12737351940272 1.41162077669157e-23 MirTarget;TargetScan -0.126731670549702 0.0049129791909471 23389960 Down regulation of miR 200b 3p by low p73 contributes to the androgen independence of prostate cancer cells; In this study we investigated the role that the interaction between miR-200b-3p and p73 plays in the proliferation of AIPC; Then we examined the effect of p73 and miR-200b-3p on the proliferation of AIPC and ADPC using CCK-8; Furthermore we investigated the regulation of miR-200b-3p by p73 prostate cancer hsa-miR-200b-3p TRIM2 -1.29335788099229 0.000268623234305059 -0.669569001903942 0.000204730952595103 TargetScan -0.116138140738029 2.11004636204701e-06 NA NA NA hsa-miR-200b-3p TRPM3 -1.29335788099229 0.000268623234305059 0.0034435230547869 0.990682400780406 TargetScan -0.188786679863538 2.03130577736745e-06 NA NA NA hsa-miR-200c-3p TSC22D1 -0.104675615392797 0.716957669484981 -0.617094445280228 5.56683999777755e-05 MirTarget;miRNATAP -0.113897512625644 1.050726013418e-05 NA NA NA hsa-miR-200a-3p TTLL7 -1.49949292595657 3.18410995256133e-05 -0.174209860799301 0.581064288483948 MirTarget -0.176447790485309 2.77405896356696e-05 NA NA NA hsa-miR-200a-5p TTLL7 -1.16865179527606 0.00105385823807419 -0.174209860799301 0.581064288483948 mirMAP -0.169009994691813 7.54040529583545e-05 NA NA NA hsa-miR-200a-3p TTR -1.49949292595657 3.18410995256133e-05 -2.49469648639749 2.55802246258903e-11 MirTarget;miRNATAP -0.138072331406437 0.00736599531244912 NA NA NA hsa-miR-200a-3p UGT1A3 -1.49949292595657 3.18410995256133e-05 -2.58217161395639 3.74628631264762e-07 MirTarget -0.439681322582052 9.01556450481012e-11 NA NA NA hsa-miR-200a-3p UGT1A4 -1.49949292595657 3.18410995256133e-05 -3.36385452578458 2.40497028381343e-09 MirTarget -0.344791383882504 6.86215634950151e-06 NA NA NA hsa-miR-200a-3p UGT1A5 -1.49949292595657 3.18410995256133e-05 -2.23550242511071 7.76708335483891e-07 MirTarget -0.343900332638932 1.45621418991874e-08 NA NA NA hsa-miR-200a-3p UGT1A9 -1.49949292595657 3.18410995256133e-05 -1.3504570414494 0.000136466111152902 MirTarget -0.20851139833931 1.16969523811527e-05 NA NA NA hsa-miR-200a-3p USH2A -1.49949292595657 3.18410995256133e-05 -2.26734306551942 1.94801387719099e-11 MirTarget -0.214486788797425 3.37839425590991e-06 NA NA NA hsa-miR-200b-3p USH2A -1.29335788099229 0.000268623234305059 -2.26734306551942 1.94801387719099e-11 TargetScan;mirMAP -0.218101584842024 3.16133293815614e-06 NA NA NA hsa-miR-200a-3p WNK3 -1.49949292595657 3.18410995256133e-05 -0.836532944570787 0.00785592148273515 mirMAP -0.216243085070345 2.47232755140786e-07 NA NA NA hsa-miR-200b-3p WNK3 -1.29335788099229 0.000268623234305059 -0.836532944570787 0.00785592148273515 TargetScan -0.216449262109057 3.55118172525738e-07 NA NA NA hsa-miR-200c-3p YPEL1 -0.104675615392797 0.716957669484981 -0.0280512828396375 0.84677585658497 MirTarget -0.104472965448243 1.68625031887984e-05 NA NA NA hsa-miR-200b-3p ZBTB16 -1.29335788099229 0.000268623234305059 -1.16865006982612 0.000104779212042064 TargetScan -0.192366707485988 2.68084651905608e-06 NA NA NA hsa-miR-200c-3p ZCCHC24 -0.104675615392797 0.716957669484981 -1.09299525922251 5.15915193886857e-19 MirTarget;miRNATAP -0.142661320486728 1.52057212151807e-11 NA NA NA hsa-miR-200a-5p ZFAND5 -1.16865179527606 0.00105385823807419 -0.89687020061194 5.59442964172277e-08 mirMAP -0.112887601530304 5.71814242999618e-07 NA NA NA hsa-miR-200c-3p ZFAND5 -0.104675615392797 0.716957669484981 -0.89687020061194 5.59442964172277e-08 mirMAP -0.133270700119052 2.02391094932053e-06 NA NA NA hsa-miR-200c-3p ZFHX4 -0.104675615392797 0.716957669484981 -0.832628706674559 7.07667307978028e-05 miRNATAP -0.101803035781504 0.00427240308951812 NA NA NA hsa-miR-200a-3p ZNF385D -1.49949292595657 3.18410995256133e-05 1.93039544568422 6.08448979085829e-06 MirTarget -0.420716428542972 7.9893974388167e-14 NA NA NA hsa-miR-200a-3p ZYG11B -1.49949292595657 3.18410995256133e-05 -0.715499327103507 8.21161432354526e-11 MirTarget -0.111591091686208 2.73122179746483e-14 NA NA NA hsa-miR-200a-5p ZYG11B -1.16865179527606 0.00105385823807419 -0.715499327103507 8.21161432354526e-11 mirMAP -0.106511471678998 9.21901978292261e-13 NA NA NA hsa-miR-200b-3p ZYG11B -1.29335788099229 0.000268623234305059 -0.715499327103507 8.21161432354526e-11 TargetScan -0.111697366634667 6.09638321870936e-14 NA NA NA