miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-125b-5p AIFM1 -1.41889699079623 1.55084253952861e-08 1.20541700578105 4.16457638553026e-16 miRNATAP -0.123147400506169 1.36317739011749e-05 NA NA NA hsa-miR-143-5p AIFM1 -1.50269375624265 1.05478816150716e-09 1.20541700578105 4.16457638553026e-16 miRNATAP -0.126079802784029 1.16008451854788e-05 NA NA NA hsa-miR-145-5p AIFM1 -2.62224605846983 2.51922187622861e-25 1.20541700578105 4.16457638553026e-16 miRNATAP -0.174994403068684 5.11571157930332e-11 20332243 Artificial overexpression of miR145 by using adenoviral vectors in prostate cancer PC-3 and DU145 cells significantly downregulated BNIP3 together with the upregulation of AIF reduced cell growth and increased cell death prostate cancer hsa-miR-199a-5p AIFM1 -0.898723308717733 0.000310515393412944 1.20541700578105 4.16457638553026e-16 miRanda -0.112392931806425 9.89195899652934e-05 NA NA NA hsa-miR-143-3p AKT1 -2.58941838935017 7.14381834445181e-28 0.518726649550649 3.20752539404609e-09 miRNAWalker2_validate -0.0532727013139973 0.00135893180360729 NA NA NA hsa-let-7a-5p AKT2 0.0957603590789535 0.432888163037337 0.0883034564987071 0.418796664117975 TargetScan -0.202513449031849 1.98155410184206e-06 NA NA NA hsa-let-7b-3p AKT2 0.348643846906648 0.0705621714966111 0.0883034564987071 0.418796664117975 MirTarget -0.0811815621930269 0.00243019338556159 NA NA NA hsa-miR-22-3p AKT2 0.738854150328267 2.88009078621328e-08 0.0883034564987071 0.418796664117975 mirMAP -0.0777116298618527 0.0443275117294164 NA NA NA hsa-miR-106a-5p AKT3 2.93836356285531 1.22956096158575e-21 -3.43161599158579 1.66296008148859e-45 miRNATAP -0.317369600274748 9.96058540650396e-17 NA NA NA hsa-miR-106b-5p AKT3 2.17788294729604 3.35797658884941e-37 -3.43161599158579 1.66296008148859e-45 miRNATAP -0.77384023814202 8.36889619294326e-34 NA NA NA hsa-miR-107 AKT3 1.80682322226628 2.47002735902976e-27 -3.43161599158579 1.66296008148859e-45 PITA;miRanda -0.749358178139839 2.93500913156473e-28 NA NA NA hsa-miR-135a-5p AKT3 0.306455109138969 0.474411025872871 -3.43161599158579 1.66296008148859e-45 miRNATAP -0.0903136297495413 0.00382017347409835 NA NA NA hsa-miR-142-3p AKT3 2.06949312533096 2.01386337282794e-15 -3.43161599158579 1.66296008148859e-45 miRanda -0.180948935312885 0.000128675904665886 NA NA NA hsa-miR-146b-5p AKT3 1.31285313891779 3.27846083137877e-10 -3.43161599158579 1.66296008148859e-45 miRNAWalker2_validate -0.286342704874082 1.55544972400913e-06 NA NA NA hsa-miR-15a-5p AKT3 1.77791080875961 1.15367449842886e-31 -3.43161599158579 1.66296008148859e-45 miRNAWalker2_validate;miRTarBase;miRNATAP -0.7539820882854 7.26616305604113e-24 NA NA NA hsa-miR-15b-5p AKT3 2.49680902955696 1.79560488884714e-45 -3.43161599158579 1.66296008148859e-45 miRNATAP -0.810414897394691 1.71270156886366e-42 NA NA NA hsa-miR-16-5p AKT3 1.88120757008208 1.6207082610779e-32 -3.43161599158579 1.66296008148859e-45 miRNAWalker2_validate;miRTarBase;miRNATAP -0.738728865229009 3.65859653391694e-25 NA NA NA hsa-miR-17-3p AKT3 1.08682607569341 6.37653314564133e-08 -3.43161599158579 1.66296008148859e-45 miRNATAP -0.464343036696147 3.1221424522953e-14 NA NA NA hsa-miR-17-5p AKT3 2.26819952852251 1.17080117367962e-29 -3.43161599158579 1.66296008148859e-45 TargetScan;miRNATAP -0.640458827936516 1.42854068142481e-30 NA NA NA hsa-miR-181a-5p AKT3 0.965577301473587 3.6533705355927e-07 -3.43161599158579 1.66296008148859e-45 miRNATAP -0.244356538730298 0.000240741930648864 NA NA NA hsa-miR-181b-5p AKT3 1.29743991759771 2.50613983144765e-11 -3.43161599158579 1.66296008148859e-45 miRNATAP -0.367499044144388 7.37280798570416e-09 NA NA NA hsa-miR-181c-5p AKT3 0.59725303236225 0.0107673525407592 -3.43161599158579 1.66296008148859e-45 miRNATAP -0.167417282526847 0.00212465114354049 NA NA NA hsa-miR-20a-5p AKT3 1.51276418035651 8.71307033346922e-13 -3.43161599158579 1.66296008148859e-45 miRNATAP -0.476962833603863 5.43567093973901e-17 NA NA NA hsa-miR-20b-5p AKT3 3.35823156722934 1.69420622814985e-14 -3.43161599158579 1.66296008148859e-45 miRNATAP -0.16668050268556 1.98962326941982e-09 NA NA NA hsa-miR-29b-2-5p AKT3 0.301372838486552 0.113552326686093 -3.43161599158579 1.66296008148859e-45 mirMAP -0.143394737057106 0.033789241035103 NA NA NA hsa-miR-3065-5p AKT3 2.75496955380748 2.37091362562179e-15 -3.43161599158579 1.66296008148859e-45 mirMAP -0.256935692718464 1.83644954842202e-12 NA NA NA hsa-miR-32-3p AKT3 2.40467177052961 5.81388257063569e-26 -3.43161599158579 1.66296008148859e-45 mirMAP -0.538549914360489 1.74555606005501e-23 NA NA NA hsa-miR-320a AKT3 0.502704491334741 0.00226252073794899 -3.43161599158579 1.66296008148859e-45 PITA;miRanda;miRNATAP -0.374653644831071 1.23499249086357e-06 NA NA NA hsa-miR-320b AKT3 1.09552613515995 1.0755423833529e-07 -3.43161599158579 1.66296008148859e-45 PITA;miRanda;miRNATAP -0.377734137856284 3.57601415107268e-10 NA NA NA hsa-miR-320c AKT3 0.733362580458909 0.00057735467707277 -3.43161599158579 1.66296008148859e-45 PITA;miRanda;miRNATAP -0.290186781399003 1.78504931910495e-06 NA NA NA hsa-miR-335-3p AKT3 1.32116009044055 1.0694366259168e-09 -3.43161599158579 1.66296008148859e-45 mirMAP -0.441312811730798 4.55844082249196e-15 NA NA NA hsa-miR-33a-3p AKT3 1.39444251212239 7.26586547385458e-13 -3.43161599158579 1.66296008148859e-45 mirMAP -0.460440663531216 2.51592095899171e-13 NA NA NA hsa-miR-340-5p AKT3 1.35294088371205 8.25205106713644e-16 -3.43161599158579 1.66296008148859e-45 mirMAP -0.564593211763196 3.59668963956168e-15 NA NA NA hsa-miR-34c-3p AKT3 0.238795980578228 0.659454056883032 -3.43161599158579 1.66296008148859e-45 PITA -0.056626526284715 0.0192273955492654 NA NA NA hsa-miR-362-3p AKT3 0.538723455753891 0.00242035379543243 -3.43161599158579 1.66296008148859e-45 miRanda -0.213434142731257 0.00314207605121887 NA NA NA hsa-miR-362-5p AKT3 0.449840584046766 0.0292542553380675 -3.43161599158579 1.66296008148859e-45 PITA;TargetScan;miRNATAP -0.202434579846135 0.00110469280138234 NA NA NA hsa-miR-421 AKT3 2.10188043858202 8.21949037851434e-21 -3.43161599158579 1.66296008148859e-45 miRanda;mirMAP -0.435334094497007 1.85858570420346e-16 NA NA NA hsa-miR-501-3p AKT3 2.18792856444299 6.3664407099549e-25 -3.43161599158579 1.66296008148859e-45 miRNATAP -0.52365432041867 6.14062594955859e-22 NA NA NA hsa-miR-502-3p AKT3 0.42804205917642 0.0100774901409161 -3.43161599158579 1.66296008148859e-45 miRNATAP -0.20143618347661 0.00914464938905735 NA NA NA hsa-miR-505-3p AKT3 1.38195153381672 2.09276757104978e-15 -3.43161599158579 1.66296008148859e-45 mirMAP -0.493100906431841 1.52916063124422e-12 22051041 We also find that Akt3 correlate inversely with miR-505 modulates drug sensitivity in MCF7-ADR breast cancer hsa-miR-548v AKT3 1.69887322011149 1.0523433577007e-09 -3.43161599158579 1.66296008148859e-45 miRNATAP -0.208987148657745 3.88904832922005e-06 NA NA NA hsa-miR-577 AKT3 3.23403680126545 4.85573112916202e-14 -3.43161599158579 1.66296008148859e-45 mirMAP -0.184901279747751 1.52901033037409e-10 NA NA NA hsa-miR-616-5p AKT3 1.97053352577988 6.50616168455898e-16 -3.43161599158579 1.66296008148859e-45 mirMAP -0.344390834959929 4.77790529041515e-12 NA NA NA hsa-miR-769-5p AKT3 1.4141195738355 1.74458572237395e-16 -3.43161599158579 1.66296008148859e-45 PITA;miRNATAP -0.669566469080538 2.3736498224376e-22 NA NA NA hsa-miR-93-5p AKT3 2.57501728456111 3.73950852324834e-39 -3.43161599158579 1.66296008148859e-45 miRNATAP -0.674069938618836 1.48264193934391e-34 NA NA NA hsa-miR-335-3p APAF1 1.32116009044055 1.0694366259168e-09 -0.0044985981329102 0.970113017391907 mirMAP -0.0734854115170956 0.00422172340202775 NA NA NA hsa-miR-335-5p APAF1 0.348427694169649 0.0962171361436908 -0.0044985981329102 0.970113017391907 miRNAWalker2_validate -0.12931882528084 1.48612749421584e-06 NA NA NA hsa-miR-125a-3p ATM 0.766248892008454 5.97048811423325e-05 -0.945652583949022 1.3895005434567e-12 miRanda -0.11181303344535 0.000941443595940847 NA NA NA hsa-miR-146b-5p ATM 1.31285313891779 3.27846083137877e-10 -0.945652583949022 1.3895005434567e-12 miRanda -0.0881255363807099 0.00380799143117382 27602131 The role of microRNA 146b miR-146b in ATC remains to be elucidated; In order to characterize the role of miR-146b in ATC overexpression or interference of miR-146b was induced in ATC cell lines and cell proliferation and migration were evaluated; The potential targets of miR-146b were searched in the Gene Expression Omnibus database for ATC and matched non-tumor control samples; The expression level of potential targets was detected following overexpression or interference of miR-146b in ATC cell lines; In addition cell migration of ATC was also affected by miR-146b; During the search for potential targets of miR-146b in ATC p21 also known as p21Waf1/Cip1 or CDKN1A was noted for its role in cell cycle progression and tumor pathogenesis; In conclusion p21 may participate in the regulation of ATC cell proliferation by miR-146b cell migration;progression thyroid cancer hsa-miR-186-5p ATM 1.01160002003511 1.0995153919986e-13 -0.945652583949022 1.3895005434567e-12 mirMAP -0.127748904919455 0.00631628674251774 NA NA NA hsa-miR-18a-5p ATM 3.22282140470889 1.9203457351048e-39 -0.945652583949022 1.3895005434567e-12 miRNAWalker2_validate;miRTarBase;MirTarget -0.122437766847937 2.89708575104783e-07 23437304;25963391;23857602;23229340 MicroRNA 18a attenuates DNA damage repair through suppressing the expression of ataxia telangiectasia mutated in colorectal cancer; Through in silico search the 3'UTR of Ataxia telangiectasia mutated ATM contains a conserved miR-18a binding site; Expression of ATM was down-regulated in CRC tumors p<0.0001 and inversely correlated with miR-18a expression r = -0.4562 p<0.01; This was further confirmed by the down-regulation of ATM protein by miR-18a; As ATM is a key enzyme in DNA damage repair we evaluated the effect of miR-18a on DNA double-strand breaks; miR-18a attenuates cellular repair of DNA double-strand breaks by directly suppressing ATM a key enzyme in DNA damage repair;However the upregulation of miR-18a suppressed the level of ataxia-telangiectasia mutated and attenuated DNA double-strand break repair after irradiation which re-sensitized the cervical cancer cells to radiotherapy by promoting apoptosis;Furthermore we used antisense oligonucleotides against micro RNAs miRNA or miRNA overexpression plasmids to study the role of miR-18a and -106a on ATM expression; Furthermore we identified that ERα activates miR-18a and -106a to downregulate ATM expression; We reveal a novel mechanism involving ERα and miR-18a and -106a regulation of ATM in breast cancer;MicroRNA 18a upregulates autophagy and ataxia telangiectasia mutated gene expression in HCT116 colon cancer cells; Previous studies showed that certain microRNAs including miR-18a potentially regulate ATM in cancer cells; However the mechanisms behind the modulation of ATM by miR-18a remain to be elucidated in colon cancer cells; In the present study we explored the impact of miR-18a on the autophagy process and ATM expression in HCT116 colon cancer cells; Western blotting and luciferase assays were implemented to explore the impact of miR-18a on ATM gene expression in HCT116 cells; Moreover miR-18a overexpression led to the upregulation of ATM expression and suppression of mTORC1 activity; Results of the present study pertaining to the role of miR-18a in regulating autophagy and ATM gene expression in colon cancer cells revealed a novel function for miR-18a in a critical cellular event and on a crucial gene with significant impacts in cancer development progression treatment and in other diseases ;;;progression colorectal cancer;cervical and endocervical cancer;breast cancer;colon cancer hsa-miR-203a-3p ATM 3.14302523096538 6.53503179786791e-20 -0.945652583949022 1.3895005434567e-12 MirTarget -0.0912913118385989 2.85939643904987e-07 24145123;27542403 miR 203 induces oxaliplatin resistance in colorectal cancer cells by negatively regulating ATM kinase; In silico analysis identified ataxia telangiectasia mutated ATM a primary mediator of the DNA damage response as a potential target of miR-203; Using TCGA database we identified a significant reverse correlation of miR-203 and ATM expression in CRC tissues; We validated ATM as a bona fide target of miR-203 in CRC cells; Mutation of the putative miR-203 binding site in the 3' untranslated region 3'UTR of the ATM mRNA abolished the inhibitory effect of miR-203 on ATM;MiR 203 inhibits tumor invasion and metastasis in gastric cancer by ATM; Our results showed that miR-203 was significantly downregulated in gastric cancer tissues and cells while ataxia telangiectasia mutated kinase ATM was upregulated in gastric cancer tissues and cells and was directly regulated by miR-203; ATM knockdown phenocopied the effect of miR-203 overexpression drug resistance;metastasis colorectal cancer;gastric cancer hsa-miR-21-5p ATM 1.51489362035879 4.99155235011048e-20 -0.945652583949022 1.3895005434567e-12 mirMAP -0.0998857918028801 0.00811208865454652 26289851 MiR-21 is an oncomiR that is overexpressed in nearly all cancers including ATC; Hence suppression of miR-21 could pave the way for ATC therapy thyroid cancer hsa-miR-324-5p ATM 2.14595874800649 3.03958987970622e-28 -0.945652583949022 1.3895005434567e-12 miRanda -0.157121054541443 3.98170646788431e-07 NA NA NA hsa-miR-335-3p ATM 1.32116009044055 1.0694366259168e-09 -0.945652583949022 1.3895005434567e-12 mirMAP -0.0888809013835764 0.00248144689869054 NA NA NA hsa-miR-339-5p ATM 1.79341790518551 3.04346641619717e-17 -0.945652583949022 1.3895005434567e-12 miRanda -0.157235214415106 6.41432567147416e-08 NA NA NA hsa-miR-421 ATM 2.10188043858202 8.21949037851434e-21 -0.945652583949022 1.3895005434567e-12 miRNAWalker2_validate;miRTarBase;MirTarget;miRanda -0.121126884863035 1.08710659687324e-05 NA NA NA hsa-miR-590-3p ATM 1.73212597984247 2.26504285146779e-20 -0.945652583949022 1.3895005434567e-12 miRanda;mirMAP -0.116304658195287 0.000454405904700417 NA NA NA hsa-miR-590-5p ATM 1.45684002317639 1.74263571329047e-15 -0.945652583949022 1.3895005434567e-12 mirMAP -0.131314156014943 0.000125752230520263 NA NA NA hsa-miR-766-3p ATM 2.69859152586189 7.66286160573257e-37 -0.945652583949022 1.3895005434567e-12 MirTarget -0.147296429325492 1.00615553207294e-07 NA NA NA hsa-miR-92a-3p ATM 1.69110879028255 8.04580501722806e-26 -0.945652583949022 1.3895005434567e-12 miRNAWalker2_validate -0.117581759290502 0.00206078677184739 NA NA NA hsa-miR-939-5p ATM 2.14910982072251 2.05036683100157e-20 -0.945652583949022 1.3895005434567e-12 MirTarget -0.1249618135545 1.03494153223572e-05 NA NA NA hsa-miR-30a-5p BAX 0.204006364430255 0.420323839030139 0.873831074781377 4.21810532132116e-11 miRNAWalker2_validate -0.0729493601831559 0.00398886829454474 NA NA NA hsa-miR-103a-3p BCL2 1.51214214201065 3.45388560860799e-21 -2.27433810416679 3.47915489242722e-19 miRNAWalker2_validate -0.315597697576902 2.55271495876843e-05 NA NA NA hsa-miR-130b-5p BCL2 3.62170467703245 4.5670833909813e-51 -2.27433810416679 3.47915489242722e-19 mirMAP -0.25124432937413 3.81318462411724e-08 27364335 The level of microRNA-130b in relationship with the expression of PPARγ VEGF-A BCL-2 and apoptosis were analyzed in 91 lung cancer patient samples using immunohistochemistry and terminal deoxynucleotidyl transferase dUTP nick end labeling TUNEL assay on tissue microarrays; In vitro and in vivo miR-130b enrichment associated with down-regulation of PPARγ up-regulation of VEGF-A and BCL-2 and decreased apoptosis lung cancer hsa-miR-142-3p BCL2 2.06949312533096 2.01386337282794e-15 -2.27433810416679 3.47915489242722e-19 miRanda -0.250450191093991 5.39360571782182e-08 NA NA NA hsa-miR-15a-5p BCL2 1.77791080875961 1.15367449842886e-31 -2.27433810416679 3.47915489242722e-19 miRNAWalker2_validate;miRTarBase -0.465800709430217 9.87466296507088e-10 25594541;26915294;18931683;25623762;22335947 MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2;miR 15a and miR 16 modulate drug resistance by targeting bcl 2 in human colon cancer cells; To investigate the reversal effect of targeted modulation of bcl-2 expression by miR-15a and miR-16 on drug resistance of human colon cancer cells;The expression of MiR-15a was significantly inhibited by Bcl-2 P < 0.05 ;poor survival;;drug resistance; breast cancer;lung cancer;prostate cancer;colon cancer;breast cancer hsa-miR-15b-3p BCL2 3.24791797249066 5.10037250255355e-48 -2.27433810416679 3.47915489242722e-19 mirMAP -0.413257509037401 1.95462151300288e-17 25594541;26915294;26884837;18449891 MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MiR 15b mediates liver cancer cells proliferation through targeting BCL 2; MiR-15b overexpression downregulated BCL2 mRNA and protein expression obviously P < 0.05; On the contrary miR-15b inhibitor transfection markedly reduced miR-15b expression in liver cancer cells P < 0.05 promoted tumor cell proliferation and increased BCL2 mRNA and protein expression; MiR-15b can inhibit HepG2 cell proliferation and down-regulate BCL2 mRNA and protein expression;miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2 ;poor survival;;drug resistance breast cancer;lung cancer;liver cancer;gastric cancer hsa-miR-15b-5p BCL2 2.49680902955696 1.79560488884714e-45 -2.27433810416679 3.47915489242722e-19 miRNAWalker2_validate;miRTarBase -0.534341272822687 6.30277434139956e-18 25594541;26915294;26884837;18449891 MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MiR 15b mediates liver cancer cells proliferation through targeting BCL 2; MiR-15b overexpression downregulated BCL2 mRNA and protein expression obviously P < 0.05; On the contrary miR-15b inhibitor transfection markedly reduced miR-15b expression in liver cancer cells P < 0.05 promoted tumor cell proliferation and increased BCL2 mRNA and protein expression; MiR-15b can inhibit HepG2 cell proliferation and down-regulate BCL2 mRNA and protein expression;miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2 ;poor survival;;drug resistance breast cancer;lung cancer;liver cancer;gastric cancer hsa-miR-16-1-3p BCL2 2.08698516922856 1.42419622445015e-24 -2.27433810416679 3.47915489242722e-19 mirMAP -0.313898712781897 5.45772550405075e-08 18931683 MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2 prostate cancer hsa-miR-16-2-3p BCL2 2.33811104285535 7.35637935757058e-33 -2.27433810416679 3.47915489242722e-19 mirMAP -0.430332199932113 1.33703020933922e-13 NA NA NA hsa-miR-16-5p BCL2 1.88120757008208 1.6207082610779e-32 -2.27433810416679 3.47915489242722e-19 miRNAWalker2_validate;miRTarBase -0.573991566753453 1.24569662345376e-15 21336967;24447552;18449891;25435430;24598659;18931683;22966344;25623762 P glycoprotein enhances radiation induced apoptotic cell death through the regulation of miR 16 and Bcl 2 expressions in hepatocellular carcinoma cells; RHepG2 cells the multidrug resistant subline of human hepatocellular carcinoma HepG2 cells expressed higher levels of Pgp as well as miR-16 and lower level of Bcl-2 than the parental cells; On the other hand ectopic mdr1 expression enhanced radiation-induced apoptosis in HepG2 cells SK-HEP-1 cells MiHa cells and furthermore induced miR-16 and suppressed its target gene Bcl-2 in HepG2 cells; Moreover the enhancement effects of Pgp and miR-16 on radiation-induced apoptosis were counteracted by overexpression of Bcl-2;To study the expression of miR-16 and bcl-2 in T lymphoblastic lymphoma/leukemia T-LBL/ALL and its relationship to prognosis; The relationship of miR-16 and bcl-2 was significantP = 0.042χ2 = 4.147; The relationship of miR-16 and bcl-2 might suggested that gene regulation may be influenced by them;miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2;We demonstrated that anti-apoptotic protein Bcl-2 was directly targeted miR-16 in paclitaxel resistant lung cancer cells; Combined overexpression of miR-16 and miR-17 greatly reduced Beclin-1 and Bcl-2 expressions respectively; miR-17 overexpression reduced cytoprotective autophagy by targeting Beclin-1 whereas overexpression of miR-16 potentiated paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2;The miR-16 expression correlated with BCL-2 protein r = 0.51 P < 0.05;MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2;The overall objective of our investigation was to assess whether miRNA-16 miR-16 is involved in the regulation of critical genes such as BCL2 that control the sensitivity of pancreatic cancer cells to apoptosis; This study showed that the ectopic overexpression of miR-16 may be therapeutically beneficial as is evidenced by impaired cell survival with concomitant attenuation of anti-apoptotic protein Bcl-2; Moreover the luciferase reporter assay suggested that miR-16 post-transcriptionally regulates Bcl-2 expression in pancreatic cancer cells through the target sites of the 3' untranslated region of this gene;miR 15a and miR 16 modulate drug resistance by targeting bcl 2 in human colon cancer cells; To investigate the reversal effect of targeted modulation of bcl-2 expression by miR-15a and miR-16 on drug resistance of human colon cancer cells ;worse prognosis;drug resistance;;;;poor survival;drug resistance liver cancer;lymphoma;gastric cancer;lung cancer;lymphoma;prostate cancer;pancreatic cancer;colon cancer hsa-miR-17-5p BCL2 2.26819952852251 1.17080117367962e-29 -2.27433810416679 3.47915489242722e-19 miRNAWalker2_validate;miRTarBase -0.317965998213712 4.04173999176792e-08 25435430 Combined overexpression of miR-16 and miR-17 greatly reduced Beclin-1 and Bcl-2 expressions respectively; miR-17 overexpression reduced cytoprotective autophagy by targeting Beclin-1 whereas overexpression of miR-16 potentiated paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2 lung cancer hsa-miR-182-5p BCL2 5.17636717835373 1.04663621342014e-76 -2.27433810416679 3.47915489242722e-19 miRNAWalker2_validate;miRTarBase;mirMAP -0.274517733664479 6.11367767187667e-14 23936432;26870290 Inhibition of proliferation and induction of autophagy by atorvastatin in PC3 prostate cancer cells correlate with downregulation of Bcl2 and upregulation of miR 182 and p21; Bcl2 and p21 were identified to be potential target genes of miR-182 in PC3 cells;The expression levels of B-cell lymphoma-2 Bcl-2 and microRNA-182 miR-182 were detected using western blot analysis and quantitative reverse transcription-polymerase chain reaction respectively; Mangiferin treatment was also able to significantly reduce Bcl-2 expression levels and enhance miR-182 expression in PC3 cells; Finally it was observed that mangiferin inhibited proliferation and induced apoptosis in PC3 human prostate cancer cells and this effect was correlated with downregulation of Bcl-2 and upregulation of miR-182 ; prostate cancer;B cell lymphoma hsa-miR-186-5p BCL2 1.01160002003511 1.0995153919986e-13 -2.27433810416679 3.47915489242722e-19 mirMAP -0.467374476249481 1.90154454130326e-07 NA NA NA hsa-miR-192-5p BCL2 1.9768050798781 2.15983442827314e-13 -2.27433810416679 3.47915489242722e-19 miRNAWalker2_validate -0.310147020401617 2.51268333125188e-12 26550150 MicroRNA 192 regulates chemo resistance of lung adenocarcinoma for gemcitabine and cisplatin combined therapy by targeting Bcl 2; In this paper we try to test whether miR-192 regulates chemo-resistance in human carcinoma A549 mice model by targeting Bcl-2; MTT assay real-time RT-PCR western blotting assay were used to investigate miR-192 expression levels cell viability ratio and Bcl-2 protein expression levels; Bcl-2 mRNA and protein expression levels up-regulated in miR-192 inhibitor treated tumor; Bcl-2 is a key regulator for miR-192 related chemotherapy resistance; In this study we demonstrate that miR-192 regulates chemoresistance for gemcitabine and cisplatin combined chemotherapy in human adenocarcinoma lung cancer A549 cells and Bcl-2 is the target of miR-192 drug resistance lung cancer hsa-miR-200a-5p BCL2 4.88923571940969 7.26134286540137e-61 -2.27433810416679 3.47915489242722e-19 mirMAP -0.258684267150084 4.38931362683037e-13 NA NA NA hsa-miR-200b-3p BCL2 4.56508753729609 3.8956399692993e-55 -2.27433810416679 3.47915489242722e-19 miRNAWalker2_validate;miRTarBase;TargetScan;mirMAP -0.229779525771855 6.09347138385388e-10 NA NA NA hsa-miR-200b-5p BCL2 4.83774625035774 1.7737491415346e-62 -2.27433810416679 3.47915489242722e-19 mirMAP -0.276418303071526 3.00252116901155e-14 NA NA NA hsa-miR-200c-3p BCL2 4.19740435353621 6.07734417092297e-49 -2.27433810416679 3.47915489242722e-19 miRNAWalker2_validate;miRTarBase;mirMAP -0.232345603642552 1.71233644523682e-09 NA NA NA hsa-miR-20a-3p BCL2 1.64245855705225 5.21058119170445e-13 -2.27433810416679 3.47915489242722e-19 mirMAP -0.108002631091923 0.0452151357354864 NA NA NA hsa-miR-20a-5p BCL2 1.51276418035651 8.71307033346922e-13 -2.27433810416679 3.47915489242722e-19 miRNAWalker2_validate;miRTarBase -0.172558667356563 0.00288472287302487 NA NA NA hsa-miR-21-5p BCL2 1.51489362035879 4.99155235011048e-20 -2.27433810416679 3.47915489242722e-19 miRNAWalker2_validate;miRTarBase -0.321186307373016 9.86147217766322e-06 21468550;25994220;25381586;26555418;23359184;22964582;21376256 BCL-2 up-regulation could be achieved by miR-21 overexpression which prevented T24 cells from apoptosis induced by doxorubicin; Furthermore the miR-21 induced BCL-2 up-regulation could be cancelled by the PI3K inhibitor LY294002;Meanwhile miR-21 loss reduced STAT3 and Bcl-2 activation causing an increase in the apoptosis of tumour cells in CAC mice;Changes in the sensitivity of osteosarcoma cells to CDDP were examined after transfection with miR-21 mimics or anti-miR-21 or bcl-2 siRNA in combination with CDDP;The expression of Bax Bcl-2 and miR-21 in parental and paclitaxel-resistant cells was detected by RT-PCR and Western blotting;Resveratrol induces apoptosis of pancreatic cancers cells by inhibiting miR 21 regulation of BCL 2 expression; We also used Western blot to measure BCL-2 protein levels after down-regulation of miR-21 expression; Besides down-regulation of miR-21 expression can inhibit BCL-2 expression in PANC-1 CFPAC-1 and MIA Paca-2 cells; Over-expression of miR-21 expression can reverse down-regulation of BCL-2 expression and apoptosis induced by resveratrol; In this study we demonstrated that the effect of resveratrol on apoptosis is due to inhibiting miR-21 regulation of BCL-2 expression;Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;Bcl 2 upregulation induced by miR 21 via a direct interaction is associated with apoptosis and chemoresistance in MIA PaCa 2 pancreatic cancer cells; However the roles and mechanisms of miRNA miR-21 in regulation of Bcl-2 in pancreatic cancer remain to be elucidated; Then luciferase activity was observed after miR-21 mimics and pRL-TK plasmids containing wild-type and mutant 3'UTRs of Bcl-2 mRNA were co-transfected; Cells transfected with miR-21 inhibitor revealed an opposite trend. There was a significant increase in luciferase activity in the cells transfected with the wild-type pRL-TK plasmid in contrast to those transfected with the mutant one indicating that miR-21 promotes Bcl-2 expression by binding directly to the 3'UTR of Bcl-2 mRNA; Upregulation of Bcl-2 directly induced by miR-21 is associated with apoptosis chemoresistance and proliferation of MIA PaCa-2 pancreatic cancer cells ;;;;;;drug resistance bladder cancer;colorectal cancer;sarcoma;breast cancer;pancreatic cancer;lung cancer;pancreatic cancer hsa-miR-215-5p BCL2 2.37852263788145 7.93880971902919e-16 -2.27433810416679 3.47915489242722e-19 miRNAWalker2_validate -0.327741357906297 1.82028017883969e-16 NA NA NA hsa-miR-224-5p BCL2 1.54698256827631 5.96883056579208e-06 -2.27433810416679 3.47915489242722e-19 mirMAP -0.101493011973287 0.00522897301242089 24796455 In addition the expressions of Bcl2 mRNA and protein were 1.05 ± 0.04 and 0.21 ± 0.03 in the miR-224 ASO group significantly lower than that in the control group 4.87 ± 0.96 and 0.88 ± 0.09 P < 0.01 gastric cancer hsa-miR-24-2-5p BCL2 1.52497306852976 3.91652723997589e-19 -2.27433810416679 3.47915489242722e-19 miRNAWalker2_validate;miRTarBase -0.407490789623484 5.7106308055647e-09 NA NA NA hsa-miR-3065-5p BCL2 2.75496955380748 2.37091362562179e-15 -2.27433810416679 3.47915489242722e-19 mirMAP -0.267441390887631 6.90885307786582e-14 NA NA NA hsa-miR-32-3p BCL2 2.40467177052961 5.81388257063569e-26 -2.27433810416679 3.47915489242722e-19 mirMAP -0.323646529838328 3.84509354828416e-09 NA NA NA hsa-miR-335-3p BCL2 1.32116009044055 1.0694366259168e-09 -2.27433810416679 3.47915489242722e-19 mirMAP -0.170698032163402 0.00273890338581498 NA NA NA hsa-miR-338-5p BCL2 0.585864914585632 0.0447092071232699 -2.27433810416679 3.47915489242722e-19 PITA -0.172952997672422 5.99861879204842e-05 NA NA NA hsa-miR-33a-5p BCL2 1.04549935225884 3.96713310508022e-05 -2.27433810416679 3.47915489242722e-19 mirMAP -0.138354431417689 0.00486118353371945 NA NA NA hsa-miR-33b-5p BCL2 2.2645934238776 2.84310918328736e-13 -2.27433810416679 3.47915489242722e-19 miRTarBase;mirMAP -0.234227891308301 5.54055558724119e-09 NA NA NA hsa-miR-342-3p BCL2 0.909988426908683 3.51879055202261e-09 -2.27433810416679 3.47915489242722e-19 miRanda -0.194247606650915 0.0163279557589942 NA NA NA hsa-miR-365a-3p BCL2 0.820066931307263 7.45093939695136e-06 -2.27433810416679 3.47915489242722e-19 miRNAWalker2_validate;miRTarBase -0.329559713600899 1.13313958423279e-06 NA NA NA hsa-miR-375 BCL2 2.57000157863852 3.63345920997148e-07 -2.27433810416679 3.47915489242722e-19 miRNAWalker2_validate -0.06405711246449 0.00889289206503126 26381132;26697569;25613180 The levels of miR-375 Bax and Bcl-2 protein expression in treated cells were determined by Western blot and RT-PCR; Moreover compared to control group the expression of Bcl-2 and miR-375 decreases with formononetin in the U2OS cells while Bax increases;Exosome Carried microRNA 375 Inhibits Cell Progression and Dissemination via Bcl 2 Blocking in Colon Cancer; RT-PCR for Bcl-2 expression showed that Bcl-2 is down-regulated for miR-375 inhibitor and up-regulated for the miR-375 mimic a result confirmed by Western blotting; The present study brings to the forefront new data that suggest miR-375 as a new player in controlling the pathways responsible for inhibiting the natural history of CRC tumor cells via the Bcl-2 pathway;mRNA levels of ERα Bcl-2 and miR-375 were quantified using real-time polymerase chain reaction; After treatment with biochanin A ERα miR-375 and Bcl-2 expression was significantly upregulated ;progression; sarcoma;colon cancer;breast cancer hsa-miR-429 BCL2 5.03984117897747 4.44936205318976e-55 -2.27433810416679 3.47915489242722e-19 miRNAWalker2_validate;miRTarBase;PITA;mirMAP -0.230293526406742 5.64487871930493e-12 23999873;26513239;26511969 MiR 429 up regulation induces apoptosis and suppresses invasion by targeting Bcl 2 and SP 1 in esophageal carcinoma; Subsequent Western blotting and luciferase reporter assays showed that miR-429 can bind to putative binding sites within the Bcl-2 and SP1 mRNA 3' untranslated regions UTRs to reduce their expression; Up-regulation of miR-429 inhibits invasion and promotes apoptosis in EC cells by targeting Bcl-2 and SP1; Our findings suggest that Bcl-2 and SP1 may serve as major targets of miR-429;MiR 429 Induces Gastric Carcinoma Cell Apoptosis Through Bcl 2; Here we studied the levels of miR-429 and anti-apoptotic protein Bcl-2 in GC specimens; We performed bioinformatics analyses and used luciferase-reporter assay to analyze the relationship between miR-429 and Bcl-2 in GC cells; MiR-429 levels were significantly decreased and Bcl-2 levels were significantly increased in GC specimens compared to the paired adjacent non-tumor gastric tissue; Moreover the levels of miR-429 and Bcl-2 inversely correlated in GC specimens; Bioinformatics analyses showed that miR-429 targeted the 3'-UTR of Bcl-2 mRNA to inhibit its translation which was confirmed by luciferase-reporter assay;MiR 429 induces apoptosis of glioblastoma cell through Bcl 2; Here we analyzed the levels of miR-429 and anti-apoptotic protein Bcl-2 in GBM specimens; We combined bioinformatics analyses and luciferase reporter assay to determine the relationship between miR-429 and Bcl-2 in GBM cells; We found that miR-429 levels were significantly decreased and Bcl-2 levels were significantly increased in GBM specimens compared to the paired adjacent non-tumor brain tissue; Moreover the levels of miR-429 and Bcl-2 inversely correlated; MiR-429 targeted the 3'-UTR of Bcl-2 mRNA to inhibit its translation ;; esophageal cancer;gastric cancer;glioblastoma hsa-miR-577 BCL2 3.23403680126545 4.85573112916202e-14 -2.27433810416679 3.47915489242722e-19 PITA -0.122559021571575 2.01645172964116e-05 NA NA NA hsa-miR-582-5p BCL2 -0.134996772656055 0.574506138816692 -2.27433810416679 3.47915489242722e-19 PITA -0.144382328226488 0.00590989701816363 NA NA NA hsa-miR-590-3p BCL2 1.73212597984247 2.26504285146779e-20 -2.27433810416679 3.47915489242722e-19 miRanda;mirMAP -0.439085242963018 3.28267754176902e-12 NA NA NA hsa-miR-590-5p BCL2 1.45684002317639 1.74263571329047e-15 -2.27433810416679 3.47915489242722e-19 miRanda -0.457259192115931 2.23014727002775e-12 NA NA NA hsa-miR-616-5p BCL2 1.97053352577988 6.50616168455898e-16 -2.27433810416679 3.47915489242722e-19 mirMAP -0.305360611244608 5.51773612613296e-10 NA NA NA hsa-miR-629-5p BCL2 1.40922412417551 5.33576724423842e-10 -2.27433810416679 3.47915489242722e-19 mirMAP -0.220932100888983 4.39874209606766e-05 NA NA NA hsa-miR-7-1-3p BCL2 1.83538862227934 3.8339472676544e-18 -2.27433810416679 3.47915489242722e-19 mirMAP -0.211454462033083 0.000209793110346434 NA NA NA hsa-miR-7-5p BCL2 3.56780774049269 4.37805017443043e-28 -2.27433810416679 3.47915489242722e-19 miRNAWalker2_validate;miRTarBase;mirMAP -0.241959412274885 2.17929816752077e-11 26464649;25862909;21750649 Western blotting was used to evaluate the effect of miR-7 on Bcl2 in A549 and H460 cells; Moreover subsequent experiments showed that BCL-2 was downregulated by miR-7 at both transcriptional and translational levels; This study further extends the biological role of miR-7 in NSCLC A549 and H460 cells and identifies BCL-2 as a novel target possibly involved in miR-7-mediated growth suppression and apoptosis induction of NSCLC cells;miR-7 overexpression correlated with diminished BCL2 expression but there was no relationship between miR-7 and EGFR expression neither in tumour samples nor in the cell lines; Of the two postulated miR-7 target genes we examined BCL2 but not EGFR seems to be a possible miR-7 target in OC;Bioinformatics predictions revealed a potential binding site of miR-7 on 3'UTR of BCL-2 and it was further confirmed by luciferase assay; Moreover subsequent experiments showed that BCL-2 was downregulated by miR-7 at both transcriptional and translational levels; These results suggest that miR-7 regulates the expression of BCL-2 through direct 3'UTR interactions ;; lung squamous cell cancer;ovarian cancer;lung squamous cell cancer hsa-miR-96-5p BCL2 5.73185523568009 7.6326624678818e-88 -2.27433810416679 3.47915489242722e-19 miRNAWalker2_validate;TargetScan -0.260291891747799 4.67993555313932e-14 NA NA NA hsa-let-7a-5p BCL2L1 0.0957603590789535 0.432888163037337 0.653114147552896 1.89075595993574e-08 TargetScan;miRNATAP -0.20488180869074 9.24166749931071e-06 26915294;20347499 As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;The let 7 family of microRNAs inhibits Bcl xL expression and potentiates sorafenib induced apoptosis in human hepatocellular carcinoma; The effect of let-7 on Bcl-xL expression was examined by Western blot and a reporter assay; Microarray analysis followed by in silico target prediction identified let-7 microRNAs as being downregulated in Huh7 hepatoma cells in comparison with primary human hepatocytes as well as possessing a putative target site in the bcl-xl mRNA poor survival; lung cancer;liver cancer hsa-let-7b-5p BCL2L1 -0.0749477218001626 0.651851405417039 0.653114147552896 1.89075595993574e-08 miRNATAP -0.116434637687203 0.000565787409674958 26915294;20347499 As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;The let 7 family of microRNAs inhibits Bcl xL expression and potentiates sorafenib induced apoptosis in human hepatocellular carcinoma; The effect of let-7 on Bcl-xL expression was examined by Western blot and a reporter assay; Microarray analysis followed by in silico target prediction identified let-7 microRNAs as being downregulated in Huh7 hepatoma cells in comparison with primary human hepatocytes as well as possessing a putative target site in the bcl-xl mRNA poor survival; lung cancer;liver cancer hsa-let-7g-5p BCL2L1 1.15803586058037 1.01768088555577e-12 0.653114147552896 1.89075595993574e-08 miRNAWalker2_validate;miRTarBase;miRNATAP -0.0706663528871144 0.0360896953823305 20347499 Over-expression of let-7c or let-7g led to a clear decrease of Bcl-xL expression in Huh7 and HepG2 cell lines; Reporter assays revealed direct post-transcriptional regulation involving let-7c or let-7g and the 3'-untranslated region of bcl-xl mRNA liver cancer hsa-miR-140-5p BCL2L1 -0.887888681168421 5.76545563709515e-08 0.653114147552896 1.89075595993574e-08 PITA;miRanda;miRNATAP -0.10076134101631 0.00286157900463845 NA NA NA hsa-miR-664a-5p BCL2L1 0.22720399592769 0.254358997345536 0.653114147552896 1.89075595993574e-08 mirMAP -0.0803995037561291 0.00419862371162163 NA NA NA hsa-miR-16-2-3p BIRC3 2.33811104285535 7.35637935757058e-33 -0.215538882967955 0.479479793713676 mirMAP -0.134696780387605 0.049841727597594 NA NA NA hsa-miR-374b-5p BIRC3 -0.162562360514506 0.226063855202319 -0.215538882967955 0.479479793713676 mirMAP -0.217456007173725 0.0464432556471679 NA NA NA hsa-miR-651-5p BIRC3 1.64229904139089 8.27195786302027e-12 -0.215538882967955 0.479479793713676 MirTarget -0.167420977307109 0.00446927238017337 NA NA NA hsa-miR-98-5p BIRC3 1.05654915824416 2.25069999789746e-15 -0.215538882967955 0.479479793713676 miRNAWalker2_validate -0.28256782629621 0.00771756416907837 NA NA NA hsa-miR-107 CAPN2 1.80682322226628 2.47002735902976e-27 -0.78862080577916 5.46203143436792e-10 miRanda -0.186106916001705 5.61494154478009e-08 NA NA NA hsa-miR-16-2-3p CAPN2 2.33811104285535 7.35637935757058e-33 -0.78862080577916 5.46203143436792e-10 mirMAP -0.182313731355844 1.75053250787879e-10 NA NA NA hsa-miR-20a-3p CAPN2 1.64245855705225 5.21058119170445e-13 -0.78862080577916 5.46203143436792e-10 MirTarget -0.151329400217641 4.79787863058158e-09 NA NA NA hsa-miR-30a-5p CAPN2 0.204006364430255 0.420323839030139 -0.78862080577916 5.46203143436792e-10 miRNAWalker2_validate -0.0761207172136892 0.00166656784873892 NA NA NA hsa-miR-320a CAPN2 0.502704491334741 0.00226252073794899 -0.78862080577916 5.46203143436792e-10 miRanda -0.111150443447163 0.00290196200300737 NA NA NA hsa-miR-320b CAPN2 1.09552613515995 1.0755423833529e-07 -0.78862080577916 5.46203143436792e-10 miRanda -0.124125068581205 2.14179243713578e-05 NA NA NA hsa-miR-320c CAPN2 0.733362580458909 0.00057735467707277 -0.78862080577916 5.46203143436792e-10 miRanda -0.121894535411938 2.99044378933737e-05 NA NA NA hsa-miR-421 CAPN2 2.10188043858202 8.21949037851434e-21 -0.78862080577916 5.46203143436792e-10 miRanda -0.173599400664298 1.31969509442356e-11 NA NA NA hsa-miR-590-3p CAPN2 1.73212597984247 2.26504285146779e-20 -0.78862080577916 5.46203143436792e-10 miRanda -0.113783337379705 0.000284401042502281 NA NA NA hsa-miR-590-5p CAPN2 1.45684002317639 1.74263571329047e-15 -0.78862080577916 5.46203143436792e-10 miRanda -0.0962247741071909 0.00306233118081014 NA NA NA hsa-miR-7-5p CAPN2 3.56780774049269 4.37805017443043e-28 -0.78862080577916 5.46203143436792e-10 miRNAWalker2_validate -0.107116397276601 1.45163500890909e-09 NA NA NA hsa-miR-16-2-3p CASP10 2.33811104285535 7.35637935757058e-33 -0.722237018535564 0.00201540365919808 mirMAP -0.143135102550704 0.00675161773720846 NA NA NA hsa-miR-181c-5p CASP10 0.59725303236225 0.0107673525407592 -0.722237018535564 0.00201540365919808 mirMAP -0.108601741648593 0.0222726466072724 NA NA NA hsa-miR-186-5p CASP10 1.01160002003511 1.0995153919986e-13 -0.722237018535564 0.00201540365919808 MirTarget;mirMAP -0.225116402437453 0.00504666148114783 NA NA NA hsa-miR-195-3p CASP10 -1.78063568244372 2.34306663657327e-11 -0.722237018535564 0.00201540365919808 mirMAP -0.119770024045882 0.00359715726228941 NA NA NA hsa-miR-19a-3p CASP10 1.84830198357993 2.4710712042826e-20 -0.722237018535564 0.00201540365919808 MirTarget;mirMAP -0.135387550949039 0.0111020187074726 NA NA NA hsa-miR-19b-3p CASP10 1.34004947278979 5.26920324973452e-16 -0.722237018535564 0.00201540365919808 MirTarget;mirMAP -0.21785019799722 0.000844041685346862 NA NA NA hsa-miR-200b-3p CASP10 4.56508753729609 3.8956399692993e-55 -0.722237018535564 0.00201540365919808 mirMAP -0.120230143406265 0.000310118450161615 NA NA NA hsa-miR-200c-3p CASP10 4.19740435353621 6.07734417092297e-49 -0.722237018535564 0.00201540365919808 mirMAP -0.0920364825958626 0.00800987587884361 NA NA NA hsa-miR-30b-3p CASP10 0.969109498000023 2.27255764801661e-07 -0.722237018535564 0.00201540365919808 MirTarget -0.200862904692654 0.000635699173069671 NA NA NA hsa-miR-320a CASP10 0.502704491334741 0.00226252073794899 -0.722237018535564 0.00201540365919808 miRanda -0.214904814415294 0.00150301427955555 NA NA NA hsa-miR-320b CASP10 1.09552613515995 1.0755423833529e-07 -0.722237018535564 0.00201540365919808 miRanda -0.182995353596746 0.000583178087706016 NA NA NA hsa-miR-320c CASP10 0.733362580458909 0.00057735467707277 -0.722237018535564 0.00201540365919808 miRanda -0.150318625527545 0.00479235635479125 NA NA NA hsa-miR-33a-3p CASP10 1.39444251212239 7.26586547385458e-13 -0.722237018535564 0.00201540365919808 mirMAP -0.266824303365183 1.64562730116149e-06 NA NA NA hsa-miR-3614-5p CASP10 3.22110456722797 1.10464223568024e-18 -0.722237018535564 0.00201540365919808 mirMAP -0.0620783640782977 0.0457828501052724 NA NA NA hsa-miR-429 CASP10 5.03984117897747 4.44936205318976e-55 -0.722237018535564 0.00201540365919808 mirMAP;miRNATAP -0.0917769408813268 0.00239904479156704 NA NA NA hsa-miR-532-5p CASP10 0.312548085442415 0.0680113392913324 -0.722237018535564 0.00201540365919808 mirMAP -0.215651219947047 0.000944065663527187 NA NA NA hsa-miR-589-3p CASP10 1.69712322956823 3.70306979263175e-12 -0.722237018535564 0.00201540365919808 mirMAP -0.196033109311809 1.39197223616807e-05 NA NA NA hsa-miR-616-5p CASP10 1.97053352577988 6.50616168455898e-16 -0.722237018535564 0.00201540365919808 mirMAP -0.11029450883099 0.0129148474579963 NA NA NA hsa-miR-744-3p CASP10 2.11872740311414 3.16695678742758e-19 -0.722237018535564 0.00201540365919808 mirMAP -0.289190288490703 6.23276824276088e-11 NA NA NA hsa-miR-766-3p CASP10 2.69859152586189 7.66286160573257e-37 -0.722237018535564 0.00201540365919808 mirMAP -0.0971960315293564 0.0434537467274551 NA NA NA hsa-let-7c-5p CASP3 -1.7227919059598 9.51049211594794e-12 0.884665192818714 9.10079583585507e-18 MirTarget -0.112614277640154 4.8020157950459e-09 NA NA NA hsa-miR-101-3p CASP3 -1.48434639686706 2.22407930927359e-19 0.884665192818714 9.10079583585507e-18 MirTarget -0.198151616475033 7.27070415878007e-12 NA NA NA hsa-miR-139-5p CASP3 -2.41416537859302 6.88706484174732e-28 0.884665192818714 9.10079583585507e-18 miRanda -0.128159697416884 1.46578793258762e-09 NA NA NA hsa-miR-140-5p CASP3 -0.887888681168421 5.76545563709515e-08 0.884665192818714 9.10079583585507e-18 miRanda -0.129919659241298 2.03218620238873e-05 NA NA NA hsa-miR-195-3p CASP3 -1.78063568244372 2.34306663657327e-11 0.884665192818714 9.10079583585507e-18 MirTarget -0.113241114270892 7.52017710294153e-10 NA NA NA hsa-miR-221-3p CASP3 -0.456639894528899 0.0246851454601987 0.884665192818714 9.10079583585507e-18 miRNAWalker2_validate -0.0515228637960159 0.0391056181318533 NA NA NA hsa-miR-26b-5p CASP3 0.300594892480765 0.0431916558729258 0.884665192818714 9.10079583585507e-18 miRNAWalker2_validate -0.124559804021021 0.000273540002705722 NA NA NA hsa-miR-28-5p CASP3 -0.466180213899448 0.00012482099258297 0.884665192818714 9.10079583585507e-18 miRanda -0.157383603168507 0.000173227334205312 NA NA NA hsa-miR-30a-5p CASP3 0.204006364430255 0.420323839030139 0.884665192818714 9.10079583585507e-18 miRNATAP -0.065640153247027 0.00101528783862575 NA NA NA hsa-miR-30c-5p CASP3 0.724673207831053 1.32226261564805e-05 0.884665192818714 9.10079583585507e-18 miRNATAP -0.100909486947423 0.000860093675866737 NA NA NA hsa-miR-374b-5p CASP3 -0.162562360514506 0.226063855202319 0.884665192818714 9.10079583585507e-18 mirMAP -0.133111689821541 0.000476760620971864 NA NA NA hsa-miR-125a-5p CASP6 -0.347216996653838 0.0211699797450826 1.39652404663041 2.2336960523703e-30 miRanda -0.170751670804751 3.35695003547664e-05 NA NA NA hsa-miR-129-5p CASP6 -0.708703178674802 0.0229981913632488 1.39652404663041 2.2336960523703e-30 MirTarget;miRanda -0.0601743177478279 0.00242033313894939 NA NA NA hsa-miR-369-3p CASP6 -0.26539037137152 0.339036790957306 1.39652404663041 2.2336960523703e-30 MirTarget -0.0825864752176738 0.000219924221552507 NA NA NA hsa-miR-542-3p CASP6 -2.02613612825205 8.22372377712865e-20 1.39652404663041 2.2336960523703e-30 miRanda -0.139380015822141 1.20718554051753e-07 NA NA NA hsa-miR-335-5p CASP7 0.348427694169649 0.0962171361436908 0.210165122667051 0.145195557548774 MirTarget -0.121896775573751 0.0001789128173445 NA NA NA hsa-miR-143-3p CASP8 -2.58941838935017 7.14381834445181e-28 0.630101598022788 1.00673762626595e-06 MirTarget -0.0705297015185209 0.00388936420123783 NA NA NA hsa-miR-26b-5p CASP8 0.300594892480765 0.0431916558729258 0.630101598022788 1.00673762626595e-06 miRNAWalker2_validate -0.124685560602374 0.00285786906194624 NA NA NA hsa-miR-125a-5p CFLAR -0.347216996653838 0.0211699797450826 0.211223354418494 0.0560710317814019 miRanda -0.0957814174776177 0.00612414354124597 NA NA NA hsa-miR-130a-3p CFLAR 0.188483151884821 0.402581058443795 0.211223354418494 0.0560710317814019 mirMAP -0.0508838184250561 0.0288879163084364 NA NA NA hsa-miR-199a-5p CFLAR -0.898723308717733 0.000310515393412944 0.211223354418494 0.0560710317814019 mirMAP -0.0529187234903859 0.0111594754905208 NA NA NA hsa-miR-320a CFLAR 0.502704491334741 0.00226252073794899 0.211223354418494 0.0560710317814019 miRanda -0.0776088672699099 0.0148311157564092 NA NA NA hsa-miR-320b CFLAR 1.09552613515995 1.0755423833529e-07 0.211223354418494 0.0560710317814019 miRanda -0.0529878129722505 0.034603839735232 NA NA NA hsa-miR-320c CFLAR 0.733362580458909 0.00057735467707277 0.211223354418494 0.0560710317814019 miRanda -0.0694014101386514 0.00553381555873829 NA NA NA hsa-miR-455-5p CFLAR -0.597175492609218 0.00643538336144091 0.211223354418494 0.0560710317814019 miRanda -0.0507244598508266 0.0334195857590925 NA NA NA hsa-miR-217 CHP2 0.915580061978196 0.0114802280304856 -0.252834762183218 0.597808448720592 miRanda -0.131550920988179 0.0355108962643695 NA NA NA hsa-miR-93-5p CHP2 2.57501728456111 3.73950852324834e-39 -0.252834762183218 0.597808448720592 MirTarget -0.292505685638271 0.00557855885537012 NA NA NA hsa-miR-152-3p CHUK -0.805678442841381 2.72254534271165e-06 0.133393655472883 0.180392829530637 MirTarget -0.0539066152961568 0.0478819154849989 NA NA NA hsa-miR-16-5p CHUK 1.88120757008208 1.6207082610779e-32 0.133393655472883 0.180392829530637 miRNAWalker2_validate;miRTarBase;MirTarget -0.0576608984788389 0.0373609680877438 NA NA NA hsa-miR-195-5p CHUK -1.81969168340723 1.04765314267131e-11 0.133393655472883 0.180392829530637 miRNAWalker2_validate;MirTarget -0.0770638418351818 5.6938551348816e-06 NA NA NA hsa-miR-23b-3p CHUK -0.940125237183254 5.29255710761003e-10 0.133393655472883 0.180392829530637 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.0964786297815534 0.00162618960903301 NA NA NA hsa-miR-29b-2-5p CHUK 0.301372838486552 0.113552326686093 0.133393655472883 0.180392829530637 MirTarget -0.0647299527902176 0.00892768293616502 NA NA NA hsa-miR-339-5p CHUK 1.79341790518551 3.04346641619717e-17 0.133393655472883 0.180392829530637 miRanda -0.0744603085342048 0.000461054109765969 NA NA NA hsa-miR-342-3p CHUK 0.909988426908683 3.51879055202261e-09 0.133393655472883 0.180392829530637 miRanda -0.0978344371459522 0.00115980927186004 NA NA NA hsa-miR-362-3p CHUK 0.538723455753891 0.00242035379543243 0.133393655472883 0.180392829530637 miRanda -0.0529687203818085 0.0463394097941527 NA NA NA hsa-miR-376c-3p CHUK -1.37160804168175 3.48481248833059e-06 0.133393655472883 0.180392829530637 MirTarget -0.0573151612279457 0.000299194360988327 NA NA NA hsa-miR-424-5p CHUK -2.23160783176865 1.2307369299943e-15 0.133393655472883 0.180392829530637 MirTarget -0.0723100800274677 7.42060635444011e-06 NA NA NA hsa-miR-497-5p CHUK -0.944286652785117 0.000311488624920066 0.133393655472883 0.180392829530637 MirTarget -0.0812207292756319 4.3351190235959e-06 NA NA NA hsa-miR-590-5p CHUK 1.45684002317639 1.74263571329047e-15 0.133393655472883 0.180392829530637 miRanda -0.0525048917372366 0.0352763941495806 NA NA NA hsa-miR-625-5p CHUK 1.10918025139677 1.4430215111181e-06 0.133393655472883 0.180392829530637 MirTarget -0.0746127798251361 0.000214466864860167 NA NA NA hsa-miR-15b-3p CSF2RB 3.24791797249066 5.10037250255355e-48 -0.486484890467304 0.0492653106554855 mirMAP -0.239462549325647 2.7162412634227e-07 NA NA NA hsa-miR-181c-5p CSF2RB 0.59725303236225 0.0107673525407592 -0.486484890467304 0.0492653106554855 MirTarget -0.109024948084997 0.0296107263897734 NA NA NA hsa-miR-181d-5p CSF2RB 1.04596097438462 3.64240164908359e-05 -0.486484890467304 0.0492653106554855 MirTarget -0.169216942718108 0.000219706607801443 NA NA NA hsa-miR-19a-3p CSF2RB 1.84830198357993 2.4710712042826e-20 -0.486484890467304 0.0492653106554855 MirTarget -0.220293608680337 8.20334211978189e-05 NA NA NA hsa-miR-19b-3p CSF2RB 1.34004947278979 5.26920324973452e-16 -0.486484890467304 0.0492653106554855 MirTarget -0.311621045595464 5.30899204328724e-06 NA NA NA hsa-miR-30b-3p CSF2RB 0.969109498000023 2.27255764801661e-07 -0.486484890467304 0.0492653106554855 MirTarget -0.335776657083712 4.48045307412306e-08 NA NA NA hsa-miR-323b-3p CSF2RB 1.35603970448795 0.000130132140927942 -0.486484890467304 0.0492653106554855 mirMAP -0.0851635910079061 0.0152369685100836 NA NA NA hsa-miR-532-5p CSF2RB 0.312548085442415 0.0680113392913324 -0.486484890467304 0.0492653106554855 MirTarget -0.190122121201631 0.0057941661922673 NA NA NA hsa-miR-139-5p CYCS -2.41416537859302 6.88706484174732e-28 0.607605124707894 4.71796320922119e-06 miRanda -0.0718007062802926 0.00784354259407075 NA NA NA hsa-miR-140-5p CYCS -0.887888681168421 5.76545563709515e-08 0.607605124707894 4.71796320922119e-06 miRanda -0.238330717985503 2.73731068681005e-10 NA NA NA hsa-miR-148a-3p CYCS 1.04160982936654 3.59186666956879e-05 0.607605124707894 4.71796320922119e-06 miRNAWalker2_validate -0.0895026972683792 0.000322180839082521 NA NA NA hsa-miR-495-3p CYCS -1.0457993800949 0.000170722019961563 0.607605124707894 4.71796320922119e-06 mirMAP -0.0968756560302455 1.90488653986144e-05 NA NA NA hsa-let-7b-5p DFFA -0.0749477218001626 0.651851405417039 0.497533606007026 8.40591464086273e-06 miRNAWalker2_validate -0.0696750077121352 0.0313917714138031 NA NA NA hsa-miR-127-3p DFFA -1.34817874284588 4.07880590250144e-07 0.497533606007026 8.40591464086273e-06 miRanda -0.0567044603008403 0.00406205377029546 NA NA NA hsa-miR-145-5p DFFA -2.62224605846983 2.51922187622861e-25 0.497533606007026 8.40591464086273e-06 miRNAWalker2_validate;miRTarBase -0.0633998081486929 0.00143829233016943 NA NA NA hsa-miR-26a-5p DFFA -0.631973911825762 2.12482912864596e-07 0.497533606007026 8.40591464086273e-06 mirMAP -0.125439043546326 0.00421360984467408 NA NA NA hsa-miR-664a-3p DFFA 0.346609433144595 0.0380664208734196 0.497533606007026 8.40591464086273e-06 mirMAP -0.177568701476902 1.95559310730538e-08 NA NA NA hsa-miR-495-3p DFFB -1.0457993800949 0.000170722019961563 0.366325854166798 0.00276767127941439 mirMAP -0.059888314646818 0.00408773963235359 NA NA NA hsa-miR-130a-3p ENDOD1 0.188483151884821 0.402581058443795 -0.983018305402329 1.61413261530687e-10 MirTarget -0.122237216213918 0.000210014883358209 NA NA NA hsa-miR-130b-3p ENDOD1 3.42039109436067 3.89459455628164e-49 -0.983018305402329 1.61413261530687e-10 MirTarget -0.172416202144002 7.9774235273053e-10 NA NA NA hsa-miR-16-1-3p ENDOD1 2.08698516922856 1.42419622445015e-24 -0.983018305402329 1.61413261530687e-10 mirMAP -0.0938224955763528 0.00665267085956312 NA NA NA hsa-miR-181b-5p ENDOD1 1.29743991759771 2.50613983144765e-11 -0.983018305402329 1.61413261530687e-10 MirTarget -0.122569281151342 0.00105052501325218 NA NA NA hsa-miR-181c-5p ENDOD1 0.59725303236225 0.0107673525407592 -0.983018305402329 1.61413261530687e-10 MirTarget -0.0968160106626777 0.00223351164659936 NA NA NA hsa-miR-181d-5p ENDOD1 1.04596097438462 3.64240164908359e-05 -0.983018305402329 1.61413261530687e-10 MirTarget -0.134355199190987 3.28125076965652e-06 NA NA NA hsa-miR-188-3p ENDOD1 1.51276577104299 1.03242769839146e-09 -0.983018305402329 1.61413261530687e-10 MirTarget -0.0732470086154933 0.0135309640618628 NA NA NA hsa-miR-192-5p ENDOD1 1.9768050798781 2.15983442827314e-13 -0.983018305402329 1.61413261530687e-10 miRNAWalker2_validate -0.0662122644693894 0.0135796994292011 NA NA NA hsa-miR-19a-3p ENDOD1 1.84830198357993 2.4710712042826e-20 -0.983018305402329 1.61413261530687e-10 mirMAP -0.18468880217662 1.54037657280111e-07 NA NA NA hsa-miR-19b-3p ENDOD1 1.34004947278979 5.26920324973452e-16 -0.983018305402329 1.61413261530687e-10 mirMAP -0.225205596989954 1.86672893627367e-07 NA NA NA hsa-miR-200b-3p ENDOD1 4.56508753729609 3.8956399692993e-55 -0.983018305402329 1.61413261530687e-10 TargetScan -0.0933655343586778 2.62705183111982e-05 NA NA NA hsa-miR-20a-3p ENDOD1 1.64245855705225 5.21058119170445e-13 -0.983018305402329 1.61413261530687e-10 MirTarget -0.138299246978472 1.21711899478522e-05 NA NA NA hsa-miR-301a-3p ENDOD1 1.9416887079489 3.80655048022936e-21 -0.983018305402329 1.61413261530687e-10 MirTarget -0.140685256541852 4.28235059307064e-05 NA NA NA hsa-miR-3065-5p ENDOD1 2.75496955380748 2.37091362562179e-15 -0.983018305402329 1.61413261530687e-10 mirMAP -0.057410607309263 0.00815983883301454 NA NA NA hsa-miR-335-3p ENDOD1 1.32116009044055 1.0694366259168e-09 -0.983018305402329 1.61413261530687e-10 MirTarget -0.116766310794052 0.000516940908303086 NA NA NA hsa-miR-3613-5p ENDOD1 2.36161077591908 1.58945209479103e-28 -0.983018305402329 1.61413261530687e-10 MirTarget -0.194185388651702 1.65074468493105e-09 NA NA NA hsa-miR-429 ENDOD1 5.03984117897747 4.44936205318976e-55 -0.983018305402329 1.61413261530687e-10 miRanda;miRNATAP -0.0796792810597519 7.5035119595353e-05 NA NA NA hsa-miR-454-3p ENDOD1 1.52878971973824 1.20025123958525e-19 -0.983018305402329 1.61413261530687e-10 MirTarget -0.199611605043321 2.10243998839991e-06 NA NA NA hsa-miR-590-3p ENDOD1 1.73212597984247 2.26504285146779e-20 -0.983018305402329 1.61413261530687e-10 miRanda -0.145116952336349 0.000133478916186516 NA NA NA hsa-miR-149-5p EXOG 1.32641446067587 9.43880833066507e-08 -0.123221850137305 0.278647532111923 MirTarget -0.0539129489293703 0.0113811244893369 NA NA NA hsa-miR-320a FADD 0.502704491334741 0.00226252073794899 0.395211849319366 2.00074603169982e-05 MirTarget;miRanda -0.0633274020929409 0.018434665955725 NA NA NA hsa-miR-106a-5p FAS 2.93836356285531 1.22956096158575e-21 -1.05687386194019 7.55208132204358e-08 miRNAWalker2_validate;miRTarBase -0.18999823845935 3.151634810423e-11 22431000;27142596 miR 106a is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS; Bioinformatic analysis combining with validation experiments identified FAS as a direct target of miR-106a; Moreover a significant inverse correlation was found between miR-106a and FAS expression not only in gastric cancer cell lines but also in gastric cancer specimens; Taken together these findings suggest that ectopicly overexpressed miR-106a may play an oncogenic role in gastric carcinogenesis and impair extrinsic apoptotic pathway through targeting FAS;Functional experiment ascertained that miR-106a interacted with FAS and mediated caspase3 pathway tumorigenesis; gastric cancer;gastric cancer hsa-miR-361-5p FAS 0.505614361096266 0.000106749108296893 -1.05687386194019 7.55208132204358e-08 miRanda -0.324709656197576 7.30285975020992e-06 NA NA NA hsa-miR-491-5p FAS 1.22779907098202 1.78415304404366e-09 -1.05687386194019 7.55208132204358e-08 miRanda -0.110094371566109 0.0160189663610756 NA NA NA hsa-miR-590-5p FAS 1.45684002317639 1.74263571329047e-15 -1.05687386194019 7.55208132204358e-08 miRanda -0.289328057507152 4.6051084259043e-09 NA NA NA hsa-miR-98-5p FAS 1.05654915824416 2.25069999789746e-15 -1.05687386194019 7.55208132204358e-08 miRNAWalker2_validate -0.515907477977624 2.04225559395848e-14 NA NA NA hsa-let-7e-5p FASLG 0.821771857232799 1.19334423679144e-10 -0.217239318473118 0.511547422426504 miRNATAP -0.402105250649756 0.000952979636647165 NA NA NA hsa-miR-25-3p FASLG 1.36338550911959 2.27429614057655e-21 -0.217239318473118 0.511547422426504 miRNATAP -0.269333992640081 0.0103331198474706 NA NA NA hsa-miR-92a-3p FASLG 1.69110879028255 8.04580501722806e-26 -0.217239318473118 0.511547422426504 miRNATAP -0.24065743933014 0.00920199729919884 NA NA NA hsa-miR-92b-3p FASLG 2.30712626248952 3.58511983194853e-19 -0.217239318473118 0.511547422426504 miRNATAP -0.162039448764915 0.00538041530505191 NA NA NA hsa-miR-218-5p IKBKB 0.496805018594163 0.0671252638705632 -0.250032252450819 0.0113514578227371 miRNAWalker2_validate;miRTarBase -0.0533307292210541 0.00188571130399485 NA NA NA hsa-miR-324-5p IKBKB 2.14595874800649 3.03958987970622e-28 -0.250032252450819 0.0113514578227371 miRanda -0.0659838696752645 0.00340249036730992 NA NA NA hsa-miR-335-5p IKBKB 0.348427694169649 0.0962171361436908 -0.250032252450819 0.0113514578227371 miRNAWalker2_validate -0.0815335707440935 0.000249292984711731 NA NA NA hsa-miR-339-5p IKBKB 1.79341790518551 3.04346641619717e-17 -0.250032252450819 0.0113514578227371 miRanda -0.0578097188711848 0.00638341102770083 NA NA NA hsa-miR-369-3p IKBKB -0.26539037137152 0.339036790957306 -0.250032252450819 0.0113514578227371 miRNATAP -0.0550458380140765 0.00111726274546695 NA NA NA hsa-miR-491-5p IKBKB 1.22779907098202 1.78415304404366e-09 -0.250032252450819 0.0113514578227371 miRanda -0.0927114255616294 3.58872815360019e-05 NA NA NA hsa-miR-17-3p IKBKG 1.08682607569341 6.37653314564133e-08 -0.133511902687256 0.13545269140533 mirMAP -0.0509366309069867 0.0139459394425325 NA NA NA hsa-miR-30e-5p IL1A 0.264119434405151 0.0488892309487705 1.05370285031977 0.00852125365211926 MirTarget -0.309016677902475 0.0318932440508872 NA NA NA hsa-miR-532-5p IL1A 0.312548085442415 0.0680113392913324 1.05370285031977 0.00852125365211926 MirTarget -0.239061110892619 0.0328106881757358 NA NA NA hsa-miR-204-5p IL1B -2.44646059671528 3.92291236341782e-09 0.47927873513659 0.0889568599428297 miRNAWalker2_validate -0.076831055194314 0.0154844771691406 NA NA NA hsa-miR-125a-3p IL1R1 0.766248892008454 5.97048811423325e-05 -1.01067684954387 7.20152474225771e-06 miRanda;miRNATAP -0.200275047295182 0.000361610590903964 NA NA NA hsa-miR-130b-5p IL1R1 3.62170467703245 4.5670833909813e-51 -1.01067684954387 7.20152474225771e-06 mirMAP -0.206036956939813 1.49711587099686e-07 NA NA NA hsa-miR-17-3p IL1R1 1.08682607569341 6.37653314564133e-08 -1.01067684954387 7.20152474225771e-06 mirMAP -0.323587503779084 5.1567068923206e-10 NA NA NA hsa-miR-197-3p IL1R1 1.87571028261536 4.68641627630274e-27 -1.01067684954387 7.20152474225771e-06 miRNAWalker2_validate -0.219895624639192 0.000158425374147513 NA NA NA hsa-miR-24-3p IL1R1 0.861226137512247 2.90830475095671e-09 -1.01067684954387 7.20152474225771e-06 miRNATAP -0.250715147797172 0.000649394884709611 NA NA NA hsa-miR-335-3p IL1R1 1.32116009044055 1.0694366259168e-09 -1.01067684954387 7.20152474225771e-06 mirMAP -0.175105601869477 0.000327341855470838 NA NA NA hsa-miR-361-5p IL1R1 0.505614361096266 0.000106749108296893 -1.01067684954387 7.20152474225771e-06 miRanda -0.246838226738216 0.00298113927350298 NA NA NA hsa-miR-106a-5p IL1RAP 2.93836356285531 1.22956096158575e-21 -0.223408280439131 0.323170002159224 MirTarget -0.113809177615219 0.000566695271583899 NA NA NA hsa-miR-204-5p IL1RAP -2.44646059671528 3.92291236341782e-09 -0.223408280439131 0.323170002159224 miRNAWalker2_validate -0.0571897659490275 0.0245932916040565 NA NA NA hsa-miR-20b-5p IL1RAP 3.35823156722934 1.69420622814985e-14 -0.223408280439131 0.323170002159224 MirTarget -0.0614727335727578 0.00930969869697908 NA NA NA hsa-miR-320a IL1RAP 0.502704491334741 0.00226252073794899 -0.223408280439131 0.323170002159224 MirTarget;PITA;miRanda -0.183384368349688 0.00492621977824756 NA NA NA hsa-miR-320c IL1RAP 0.733362580458909 0.00057735467707277 -0.223408280439131 0.323170002159224 MirTarget;PITA;miRanda -0.125397920826046 0.0145655657704291 NA NA NA hsa-miR-339-5p IL1RAP 1.79341790518551 3.04346641619717e-17 -0.223408280439131 0.323170002159224 miRanda -0.107924542451409 0.0266561714602859 NA NA NA hsa-miR-375 IL1RAP 2.57000157863852 3.63345920997148e-07 -0.223408280439131 0.323170002159224 miRNAWalker2_validate;miRanda -0.106268202835468 2.55032199636992e-07 NA NA NA hsa-miR-7-1-3p IL1RAP 1.83538862227934 3.8339472676544e-18 -0.223408280439131 0.323170002159224 MirTarget -0.107035907171726 0.0283415057189761 NA NA NA hsa-miR-328-3p IRAK1 0.38584080591751 0.0309917239548872 0.964446061564813 3.45773418473585e-11 miRNAWalker2_validate -0.0984094114041311 0.0129394069318452 NA NA NA hsa-miR-320a IRAK2 0.502704491334741 0.00226252073794899 -0.414675653808451 0.127809957552763 miRanda;miRNATAP -0.380227998386801 1.0638333758965e-06 NA NA NA hsa-miR-320b IRAK2 1.09552613515995 1.0755423833529e-07 -0.414675653808451 0.127809957552763 miRanda;miRNATAP -0.218749724027641 0.000390978128095876 NA NA NA hsa-miR-320c IRAK2 0.733362580458909 0.00057735467707277 -0.414675653808451 0.127809957552763 miRanda;miRNATAP -0.22071921342854 0.000342738626151263 NA NA NA hsa-miR-335-5p IRAK2 0.348427694169649 0.0962171361436908 -0.414675653808451 0.127809957552763 miRNAWalker2_validate -0.216401174483524 0.000442483169798955 NA NA NA hsa-miR-339-5p IRAK2 1.79341790518551 3.04346641619717e-17 -0.414675653808451 0.127809957552763 miRanda -0.215182632794114 0.000229834528841164 NA NA NA hsa-miR-34c-5p IRAK2 -0.27131143866706 0.619248345070017 -0.414675653808451 0.127809957552763 miRanda -0.157496538392449 9.72016652863861e-12 NA NA NA hsa-miR-616-5p IRAK2 1.97053352577988 6.50616168455898e-16 -0.414675653808451 0.127809957552763 mirMAP -0.10763388569467 0.0366565114184564 NA NA NA hsa-miR-141-3p IRAK3 4.68123467996176 4.92783859837668e-50 -1.69522054559947 1.05588968238385e-10 mirMAP -0.242592238289148 4.47502246682903e-12 NA NA NA hsa-miR-148b-5p IRAK3 2.24566117508049 6.39491669468652e-28 -1.69522054559947 1.05588968238385e-10 mirMAP -0.283322388457598 9.78494828095612e-07 NA NA NA hsa-miR-16-1-3p IRAK3 2.08698516922856 1.42419622445015e-24 -1.69522054559947 1.05588968238385e-10 mirMAP -0.304827050846363 1.87172878894472e-07 NA NA NA hsa-miR-16-2-3p IRAK3 2.33811104285535 7.35637935757058e-33 -1.69522054559947 1.05588968238385e-10 mirMAP -0.266414543119834 8.88485047125139e-06 NA NA NA hsa-miR-16-5p IRAK3 1.88120757008208 1.6207082610779e-32 -1.69522054559947 1.05588968238385e-10 miRNAWalker2_validate -0.307761324488401 3.61510495473389e-05 NA NA NA hsa-miR-186-5p IRAK3 1.01160002003511 1.0995153919986e-13 -1.69522054559947 1.05588968238385e-10 mirMAP -0.345265487339919 0.000158948030471523 NA NA NA hsa-miR-188-5p IRAK3 1.83180846049089 3.69593490679723e-16 -1.69522054559947 1.05588968238385e-10 mirMAP -0.263970744333138 1.16325078360851e-06 NA NA NA hsa-miR-200a-3p IRAK3 4.83505960801065 7.294437616154e-52 -1.69522054559947 1.05588968238385e-10 mirMAP -0.237751937622156 4.97228636579741e-12 NA NA NA hsa-miR-205-5p IRAK3 6.03337360102976 5.5401539902434e-32 -1.69522054559947 1.05588968238385e-10 mirMAP -0.134671927949662 2.50581783672573e-09 NA NA NA hsa-miR-20a-3p IRAK3 1.64245855705225 5.21058119170445e-13 -1.69522054559947 1.05588968238385e-10 mirMAP -0.245125917462143 5.73688109645457e-06 NA NA NA hsa-miR-25-3p IRAK3 1.36338550911959 2.27429614057655e-21 -1.69522054559947 1.05588968238385e-10 mirMAP -0.307862514280313 0.000287840701480461 NA NA NA hsa-miR-32-5p IRAK3 1.61585199704519 4.93530744182272e-20 -1.69522054559947 1.05588968238385e-10 mirMAP -0.271958259426309 8.21275734119662e-05 NA NA NA hsa-miR-3200-3p IRAK3 3.8958998084953 3.77457683793305e-36 -1.69522054559947 1.05588968238385e-10 mirMAP -0.27277226387908 9.09063611171102e-14 NA NA NA hsa-miR-320a IRAK3 0.502704491334741 0.00226252073794899 -1.69522054559947 1.05588968238385e-10 miRanda -0.235790313369579 0.00232012650063072 NA NA NA hsa-miR-320b IRAK3 1.09552613515995 1.0755423833529e-07 -1.69522054559947 1.05588968238385e-10 miRanda -0.310465583622517 2.63204675383129e-07 NA NA NA hsa-miR-320c IRAK3 0.733362580458909 0.00057735467707277 -1.69522054559947 1.05588968238385e-10 miRanda -0.238409845829594 8.45727468281767e-05 NA NA NA hsa-miR-324-5p IRAK3 2.14595874800649 3.03958987970622e-28 -1.69522054559947 1.05588968238385e-10 miRanda -0.3574381938153 3.43390708002652e-09 NA NA NA hsa-miR-330-3p IRAK3 1.76420587112262 1.73634190017122e-17 -1.69522054559947 1.05588968238385e-10 mirMAP -0.193770097585812 0.00105848851948716 NA NA NA hsa-miR-330-5p IRAK3 2.22118657747194 1.60999465282299e-26 -1.69522054559947 1.05588968238385e-10 miRanda -0.116175880967911 0.0438169238265274 NA NA NA hsa-miR-335-3p IRAK3 1.32116009044055 1.0694366259168e-09 -1.69522054559947 1.05588968238385e-10 mirMAP -0.251249357199523 1.16295812938696e-05 NA NA NA hsa-miR-33a-5p IRAK3 1.04549935225884 3.96713310508022e-05 -1.69522054559947 1.05588968238385e-10 mirMAP -0.233575019762281 2.14890797219709e-06 NA NA NA hsa-miR-33b-5p IRAK3 2.2645934238776 2.84310918328736e-13 -1.69522054559947 1.05588968238385e-10 mirMAP -0.176845945377717 1.60089051271538e-05 NA NA NA hsa-miR-340-5p IRAK3 1.35294088371205 8.25205106713644e-16 -1.69522054559947 1.05588968238385e-10 mirMAP -0.180586971537201 0.0141452640015367 NA NA NA hsa-miR-361-5p IRAK3 0.505614361096266 0.000106749108296893 -1.69522054559947 1.05588968238385e-10 miRanda;mirMAP -0.382234788348293 9.16568336116926e-05 NA NA NA hsa-miR-363-3p IRAK3 2.83477134110563 1.70448519090191e-12 -1.69522054559947 1.05588968238385e-10 mirMAP -0.105739481145578 0.000574287783122186 NA NA NA hsa-miR-421 IRAK3 2.10188043858202 8.21949037851434e-21 -1.69522054559947 1.05588968238385e-10 miRanda;mirMAP -0.239570832781546 9.1737277869239e-06 NA NA NA hsa-miR-429 IRAK3 5.03984117897747 4.44936205318976e-55 -1.69522054559947 1.05588968238385e-10 miRanda -0.257073415376202 2.02768506152516e-14 NA NA NA hsa-miR-501-5p IRAK3 1.63365089104021 2.93689344466334e-15 -1.69522054559947 1.05588968238385e-10 mirMAP -0.273455404124002 3.83075840799435e-06 NA NA NA hsa-miR-505-3p IRAK3 1.38195153381672 2.09276757104978e-15 -1.69522054559947 1.05588968238385e-10 mirMAP -0.166559309996969 0.0191016116983562 NA NA NA hsa-miR-577 IRAK3 3.23403680126545 4.85573112916202e-14 -1.69522054559947 1.05588968238385e-10 mirMAP -0.138265935216654 1.87035608881627e-06 NA NA NA hsa-miR-589-3p IRAK3 1.69712322956823 3.70306979263175e-12 -1.69522054559947 1.05588968238385e-10 mirMAP -0.229540809921381 8.41914086183947e-06 NA NA NA hsa-miR-590-3p IRAK3 1.73212597984247 2.26504285146779e-20 -1.69522054559947 1.05588968238385e-10 miRanda;mirMAP -0.195155754285164 0.0027598695150413 NA NA NA hsa-miR-590-5p IRAK3 1.45684002317639 1.74263571329047e-15 -1.69522054559947 1.05588968238385e-10 mirMAP -0.274817800616792 4.21381438889913e-05 NA NA NA hsa-miR-616-5p IRAK3 1.97053352577988 6.50616168455898e-16 -1.69522054559947 1.05588968238385e-10 mirMAP -0.208251429115427 3.58509059442888e-05 NA NA NA hsa-miR-660-5p IRAK3 0.20661370223084 0.267201322788119 -1.69522054559947 1.05588968238385e-10 mirMAP -0.142827448745001 0.0378142602155932 NA NA NA hsa-miR-7-1-3p IRAK3 1.83538862227934 3.8339472676544e-18 -1.69522054559947 1.05588968238385e-10 mirMAP -0.188793758690058 0.00108932454359912 NA NA NA hsa-miR-9-3p IRAK3 2.20853188955728 2.21538083391586e-07 -1.69522054559947 1.05588968238385e-10 mirMAP -0.177363856060886 1.03061286645794e-09 NA NA NA hsa-miR-92a-3p IRAK3 1.69110879028255 8.04580501722806e-26 -1.69522054559947 1.05588968238385e-10 mirMAP -0.465299735721394 2.56818583787737e-10 NA NA NA hsa-miR-92b-3p IRAK3 2.30712626248952 3.58511983194853e-19 -1.69522054559947 1.05588968238385e-10 mirMAP -0.15255278687895 0.00121940763311296 NA NA NA hsa-miR-193a-3p IRAK4 0.422281760608533 0.0531653219715062 -0.111148354678126 0.277229635340825 miRanda -0.0851845697942092 0.000110891347103087 NA NA NA hsa-miR-421 IRAK4 2.10188043858202 8.21949037851434e-21 -0.111148354678126 0.277229635340825 miRanda -0.0830978874955373 5.10571695730021e-05 NA NA NA hsa-miR-106a-5p MAP3K14 2.93836356285531 1.22956096158575e-21 -0.70605173496358 5.07075189755721e-08 MirTarget -0.0811828166363662 2.16915863121525e-05 NA NA NA hsa-miR-106b-5p MAP3K14 2.17788294729604 3.35797658884941e-37 -0.70605173496358 5.07075189755721e-08 MirTarget -0.139514840030846 2.85171676500399e-05 NA NA NA hsa-miR-1254 MAP3K14 2.6936072043758 2.69365736193576e-22 -0.70605173496358 5.07075189755721e-08 MirTarget -0.110825139833275 1.92365564851591e-06 NA NA NA hsa-miR-17-3p MAP3K14 1.08682607569341 6.37653314564133e-08 -0.70605173496358 5.07075189755721e-08 MirTarget -0.124404849656708 4.33091487613976e-05 NA NA NA hsa-miR-17-5p MAP3K14 2.26819952852251 1.17080117367962e-29 -0.70605173496358 5.07075189755721e-08 MirTarget -0.131774818000865 4.77893535672225e-06 NA NA NA hsa-miR-185-3p MAP3K14 2.82526569430707 2.7982931341201e-29 -0.70605173496358 5.07075189755721e-08 MirTarget -0.0758471170397371 0.00122661110354145 NA NA NA hsa-miR-1976 MAP3K14 2.88535661397958 1.06588775996244e-47 -0.70605173496358 5.07075189755721e-08 MirTarget -0.0758924625546123 0.00768884515775903 NA NA NA hsa-miR-20a-5p MAP3K14 1.51276418035651 8.71307033346922e-13 -0.70605173496358 5.07075189755721e-08 MirTarget -0.109905376425843 0.000118622893269161 NA NA NA hsa-miR-20b-5p MAP3K14 3.35823156722934 1.69420622814985e-14 -0.70605173496358 5.07075189755721e-08 MirTarget -0.0511321028955545 0.000185473161083612 NA NA NA hsa-miR-2110 MAP3K14 1.57021301515342 7.33611160219404e-14 -0.70605173496358 5.07075189755721e-08 MirTarget -0.0583506047554273 0.0456449582834743 NA NA NA hsa-miR-331-3p MAP3K14 2.42972679869287 3.56287442547219e-34 -0.70605173496358 5.07075189755721e-08 MirTarget -0.0903969937598672 0.00172510202471923 NA NA NA hsa-miR-345-5p MAP3K14 3.05579314759496 5.84282972055708e-34 -0.70605173496358 5.07075189755721e-08 MirTarget -0.0940974659481865 3.44288985173779e-05 NA NA NA hsa-miR-362-3p MAP3K14 0.538723455753891 0.00242035379543243 -0.70605173496358 5.07075189755721e-08 miRanda -0.06978455945549 0.0476324067643707 NA NA NA hsa-miR-429 MAP3K14 5.03984117897747 4.44936205318976e-55 -0.70605173496358 5.07075189755721e-08 miRNATAP -0.0938583347924354 1.85992805596167e-08 NA NA NA hsa-miR-874-3p MAP3K14 1.53720689926895 1.73287665493732e-10 -0.70605173496358 5.07075189755721e-08 MirTarget -0.106182526872098 2.42543050200453e-05 NA NA NA hsa-miR-93-5p MAP3K14 2.57501728456111 3.73950852324834e-39 -0.70605173496358 5.07075189755721e-08 MirTarget -0.174837552790403 7.77743197437462e-10 NA NA NA hsa-miR-129-5p NFKB1 -0.708703178674802 0.0229981913632488 -0.722245044536428 3.55878417484013e-08 PITA;miRanda -0.0507441979532253 0.0120618590801235 NA NA NA hsa-miR-16-5p NFKB1 1.88120757008208 1.6207082610779e-32 -0.722245044536428 3.55878417484013e-08 miRNAWalker2_validate -0.138880060466043 0.000169575494188876 NA NA NA hsa-miR-340-5p NFKB1 1.35294088371205 8.25205106713644e-16 -0.722245044536428 3.55878417484013e-08 miRNATAP -0.215047100839764 1.91702638367878e-09 NA NA NA hsa-miR-429 NFKB1 5.03984117897747 4.44936205318976e-55 -0.722245044536428 3.55878417484013e-08 miRanda;miRNATAP -0.0662096314736246 0.0001022582730625 NA NA NA hsa-miR-625-5p NFKB1 1.10918025139677 1.4430215111181e-06 -0.722245044536428 3.55878417484013e-08 MirTarget -0.0812675509607301 0.00271053625742948 NA NA NA hsa-miR-671-5p NFKB1 2.3716249856662 4.71138196574897e-33 -0.722245044536428 3.55878417484013e-08 MirTarget -0.0944577096589201 0.00134196951738633 NA NA NA hsa-miR-92a-3p NFKB1 1.69110879028255 8.04580501722806e-26 -0.722245044536428 3.55878417484013e-08 miRNAWalker2_validate -0.143138721825141 0.000106322402352752 NA NA NA hsa-let-7d-5p NGF 0.769608372318022 2.02277615276328e-07 -2.90283283942283 2.98491219814929e-20 MirTarget -0.310427691994489 0.00312226399237539 NA NA NA hsa-let-7e-5p NGF 0.821771857232799 1.19334423679144e-10 -2.90283283942283 2.98491219814929e-20 MirTarget -0.414080030783658 0.000641236102976328 NA NA NA hsa-let-7f-5p NGF 0.266716939373151 0.0560684654270442 -2.90283283942283 2.98491219814929e-20 MirTarget -0.263192761814141 0.0202237869850424 NA NA NA hsa-let-7g-5p NGF 1.15803586058037 1.01768088555577e-12 -2.90283283942283 2.98491219814929e-20 MirTarget -0.366047729422885 9.66396928065343e-05 NA NA NA hsa-miR-125a-3p NGF 0.766248892008454 5.97048811423325e-05 -2.90283283942283 2.98491219814929e-20 miRanda -0.173468229261626 0.0339554021871721 NA NA NA hsa-miR-320b NGF 1.09552613515995 1.0755423833529e-07 -2.90283283942283 2.98491219814929e-20 miRanda -0.157586049189284 0.0357299803729697 NA NA NA hsa-miR-423-5p NGF 0.875722574439598 4.995026399727e-09 -2.90283283942283 2.98491219814929e-20 MirTarget;miRNATAP -0.318848895581724 0.00203510875574725 NA NA NA hsa-miR-429 NGF 5.03984117897747 4.44936205318976e-55 -2.90283283942283 2.98491219814929e-20 miRanda -0.332764456621486 6.08241694825502e-16 NA NA NA hsa-miR-98-5p NGF 1.05654915824416 2.25069999789746e-15 -2.90283283942283 2.98491219814929e-20 MirTarget -0.461630641343485 5.32412863768439e-05 NA NA NA hsa-let-7a-5p PIK3CA 0.0957603590789535 0.432888163037337 -0.345983742315519 0.043351021840731 TargetScan -0.282361162054596 2.71790071760782e-05 NA NA NA hsa-miR-142-5p PIK3CA 1.99051987846668 1.30874707506504e-14 -0.345983742315519 0.043351021840731 mirMAP -0.125473205987229 3.38212043960518e-05 NA NA NA hsa-miR-146a-5p PIK3CA 2.42440263823594 1.14038326184727e-15 -0.345983742315519 0.043351021840731 mirMAP -0.104115491289834 5.25326963615944e-05 NA NA NA hsa-miR-148b-3p PIK3CA 1.80941322303736 4.89099431390024e-33 -0.345983742315519 0.043351021840731 miRNAWalker2_validate -0.120727582694558 0.0160751867264755 NA NA NA hsa-miR-195-3p PIK3CA -1.78063568244372 2.34306663657327e-11 -0.345983742315519 0.043351021840731 mirMAP -0.10504713266127 0.000449449986396603 NA NA NA hsa-miR-200b-3p PIK3CA 4.56508753729609 3.8956399692993e-55 -0.345983742315519 0.043351021840731 TargetScan -0.0563031703507928 0.0211117441359813 NA NA NA hsa-miR-32-3p PIK3CA 2.40467177052961 5.81388257063569e-26 -0.345983742315519 0.043351021840731 mirMAP -0.150713425564004 2.55708659744674e-05 NA NA NA hsa-miR-320a PIK3CA 0.502704491334741 0.00226252073794899 -0.345983742315519 0.043351021840731 miRanda -0.20081596115808 4.4592151711931e-05 NA NA NA hsa-miR-320c PIK3CA 0.733362580458909 0.00057735467707277 -0.345983742315519 0.043351021840731 miRanda -0.0922230055606849 0.0177958028796002 NA NA NA hsa-miR-335-5p PIK3CA 0.348427694169649 0.0962171361436908 -0.345983742315519 0.043351021840731 miRNAWalker2_validate -0.215937651720674 1.72751768379796e-08 NA NA NA hsa-miR-339-5p PIK3CA 1.79341790518551 3.04346641619717e-17 -0.345983742315519 0.043351021840731 miRanda -0.14390126551106 8.7779776230651e-05 NA NA NA hsa-miR-491-5p PIK3CA 1.22779907098202 1.78415304404366e-09 -0.345983742315519 0.043351021840731 miRanda -0.103612882761334 0.00826637967215544 NA NA NA hsa-miR-590-3p PIK3CA 1.73212597984247 2.26504285146779e-20 -0.345983742315519 0.043351021840731 miRanda;mirMAP -0.10380117920985 0.0127324700300465 NA NA NA hsa-miR-590-5p PIK3CA 1.45684002317639 1.74263571329047e-15 -0.345983742315519 0.043351021840731 miRanda -0.102187710757736 0.0177151298656796 NA NA NA hsa-miR-7-1-3p PIK3CA 1.83538862227934 3.8339472676544e-18 -0.345983742315519 0.043351021840731 mirMAP -0.123755339715695 0.000789077465161951 NA NA NA hsa-miR-96-5p PIK3CA 5.73185523568009 7.6326624678818e-88 -0.345983742315519 0.043351021840731 TargetScan -0.0953462902642617 2.8352281832497e-05 NA NA NA hsa-miR-130a-3p PIK3CB 0.188483151884821 0.402581058443795 0.172716405823894 0.124548303537208 miRNATAP -0.116270757125657 6.79070150875769e-07 NA NA NA hsa-miR-195-3p PIK3CB -1.78063568244372 2.34306663657327e-11 0.172716405823894 0.124548303537208 mirMAP -0.053044648216961 0.00691575107011865 NA NA NA hsa-miR-199b-3p PIK3CB -0.58683360081722 0.0141744165459456 0.172716405823894 0.124548303537208 miRNATAP -0.0999326218383338 5.55729034479667e-06 NA NA NA hsa-miR-204-5p PIK3CB -2.44646059671528 3.92291236341782e-09 0.172716405823894 0.124548303537208 miRNATAP -0.067568673181744 5.65205915868257e-08 NA NA NA hsa-miR-214-3p PIK3CB -0.343992156003432 0.200021875722178 0.172716405823894 0.124548303537208 miRNATAP -0.104331121920421 1.17561463635879e-07 NA NA NA hsa-miR-532-3p PIK3CB 1.39711438989287 4.70050755096321e-15 0.172716405823894 0.124548303537208 miRNATAP -0.0910980370892069 0.00162883361237188 NA NA NA hsa-miR-30b-3p PIK3CD 0.969109498000023 2.27255764801661e-07 -0.676499207288064 0.000459907467864123 MirTarget -0.10326064516407 0.0343455571467454 NA NA NA hsa-miR-320b PIK3CD 1.09552613515995 1.0755423833529e-07 -0.676499207288064 0.000459907467864123 miRanda -0.107028808002669 0.0152846997405826 NA NA NA hsa-miR-320c PIK3CD 0.733362580458909 0.00057735467707277 -0.676499207288064 0.000459907467864123 miRanda -0.0941146483074195 0.0329619967220631 NA NA NA hsa-miR-324-5p PIK3CD 2.14595874800649 3.03958987970622e-28 -0.676499207288064 0.000459907467864123 miRanda -0.111000923802641 0.0125316965829497 NA NA NA hsa-miR-484 PIK3CD 2.63208825865802 1.33951432214396e-44 -0.676499207288064 0.000459907467864123 MirTarget;miRNATAP -0.123483002706764 0.0052231745015737 NA NA NA hsa-miR-335-3p PIK3CG 1.32116009044055 1.0694366259168e-09 -0.970950676011351 0.000520138477969579 mirMAP -0.230327548730514 0.000131730479980283 NA NA NA hsa-miR-3607-3p PIK3CG 0.688430584371371 0.0113712970033852 -0.970950676011351 0.000520138477969579 mirMAP -0.0966905839142819 0.048707834280967 NA NA NA hsa-miR-421 PIK3CG 2.10188043858202 8.21949037851434e-21 -0.970950676011351 0.000520138477969579 miRanda -0.153900381047187 0.00696313023192891 NA NA NA hsa-miR-103a-3p PIK3R1 1.51214214201065 3.45388560860799e-21 -0.896262231955658 0.000721334118501467 MirTarget;miRNATAP -0.235752583748205 0.00182530860043885 NA NA NA hsa-miR-106b-5p PIK3R1 2.17788294729604 3.35797658884941e-37 -0.896262231955658 0.000721334118501467 MirTarget;miRNATAP -0.299555941393943 9.34688034041303e-06 NA NA NA hsa-miR-107 PIK3R1 1.80682322226628 2.47002735902976e-27 -0.896262231955658 0.000721334118501467 MirTarget;PITA;miRanda;miRNATAP -0.298951963010546 2.58718196859597e-05 NA NA NA hsa-miR-128-3p PIK3R1 1.96532529867919 3.24422417643655e-26 -0.896262231955658 0.000721334118501467 MirTarget -0.236383368702209 0.000225736072605137 25962360 miR 128 3p suppresses hepatocellular carcinoma proliferation by regulating PIK3R1 and is correlated with the prognosis of HCC patients; Mechanistically miR-128-3p was confirmed to regulate PIK3R1 p85α expression thereby suppressing phosphatidylinositol 3-kinase PI3K/AKT pathway activation using qRT-PCR and western blot analysis; Hence we conclude that miR-128-3p which is frequently downregulated in HCC inhibits HCC progression by regulating PIK3R1 and PI3K/AKT activation and is a prognostic marker for HCC patients worse prognosis;progression liver cancer hsa-miR-1301-3p PIK3R1 3.0423763268248 1.30440647030961e-49 -0.896262231955658 0.000721334118501467 MirTarget -0.135486055411308 0.0134651144045122 NA NA NA hsa-miR-144-3p PIK3R1 0.898587557783135 0.0096798632650616 -0.896262231955658 0.000721334118501467 mirMAP -0.08542426533148 0.0209338963775036 NA NA NA hsa-miR-15b-5p PIK3R1 2.49680902955696 1.79560488884714e-45 -0.896262231955658 0.000721334118501467 MirTarget -0.196180487435026 0.00235857603405551 NA NA NA hsa-miR-16-2-3p PIK3R1 2.33811104285535 7.35637935757058e-33 -0.896262231955658 0.000721334118501467 MirTarget -0.250280947044668 2.68775545469703e-05 NA NA NA hsa-miR-16-5p PIK3R1 1.88120757008208 1.6207082610779e-32 -0.896262231955658 0.000721334118501467 MirTarget -0.156077484095526 0.036191217500989 NA NA NA hsa-miR-17-5p PIK3R1 2.26819952852251 1.17080117367962e-29 -0.896262231955658 0.000721334118501467 MirTarget;TargetScan;miRNATAP -0.217041355750809 0.000218848810833938 NA NA NA hsa-miR-185-5p PIK3R1 1.98430335062845 1.43827631289268e-30 -0.896262231955658 0.000721334118501467 miRNATAP -0.263198807205621 0.000112986161971269 NA NA NA hsa-miR-20a-5p PIK3R1 1.51276418035651 8.71307033346922e-13 -0.896262231955658 0.000721334118501467 MirTarget;miRNATAP -0.21826294859526 0.000167225635477916 NA NA NA hsa-miR-21-5p PIK3R1 1.51489362035879 4.99155235011048e-20 -0.896262231955658 0.000721334118501467 miRNAWalker2_validate;MirTarget;miRNATAP -0.420316110829884 6.41614927068986e-09 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-212-3p PIK3R1 0.359625658025173 0.0794994042981727 -0.896262231955658 0.000721334118501467 MirTarget -0.301441525600945 8.21532266024133e-07 NA NA NA hsa-miR-221-3p PIK3R1 -0.456639894528899 0.0246851454601987 -0.896262231955658 0.000721334118501467 MirTarget -0.45622506157999 4.71328774203518e-14 NA NA NA hsa-miR-222-3p PIK3R1 -0.0212380709270086 0.917267501280395 -0.896262231955658 0.000721334118501467 MirTarget -0.409437285056164 1.54377692233843e-11 NA NA NA hsa-miR-29a-3p PIK3R1 -1.072406068306 3.86656176405007e-09 -0.896262231955658 0.000721334118501467 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.225383148826672 0.000967268136290665 NA NA NA hsa-miR-3065-5p PIK3R1 2.75496955380748 2.37091362562179e-15 -0.896262231955658 0.000721334118501467 MirTarget;mirMAP;miRNATAP -0.100736723641004 0.00626878854701686 NA NA NA hsa-miR-324-3p PIK3R1 2.34606663412817 2.38165582241626e-31 -0.896262231955658 0.000721334118501467 MirTarget;PITA;miRNATAP -0.212262790710396 0.000266962746037377 NA NA NA hsa-miR-330-3p PIK3R1 1.76420587112262 1.73634190017122e-17 -0.896262231955658 0.000721334118501467 MirTarget;PITA;miRNATAP -0.210228709386418 0.000340631692511873 NA NA NA hsa-miR-335-3p PIK3R1 1.32116009044055 1.0694366259168e-09 -0.896262231955658 0.000721334118501467 mirMAP -0.21997630859281 0.000114966213059553 NA NA NA hsa-miR-338-5p PIK3R1 0.585864914585632 0.0447092071232699 -0.896262231955658 0.000721334118501467 PITA -0.192397788736257 8.42190818306769e-06 NA NA NA hsa-miR-409-3p PIK3R1 0.406022791580291 0.109700726870361 -0.896262231955658 0.000721334118501467 mirMAP -0.0995908550989387 0.045994795878534 NA NA NA hsa-miR-486-5p PIK3R1 0.630265651169473 0.0356088002128703 -0.896262231955658 0.000721334118501467 MirTarget;PITA;miRanda;miRNATAP -0.117971140187445 0.00496239949257764 25475121 Mechanistically miR-486-5p was confirmed to directly target PIK3R1 expression thereby suppressing phosphatidylinositol 3-kinase-AKT pathway activation by dual luciferase reporter assay and real-time quantitative RT-PCR and western blot analysis; In addition PIK3R1 knockdown mimicked the effects of miR-486-5p overexpression by inhibiting HCC growth migration and invasion; Furthermore correlation analysis Kaplan-Meier estimates and Cox proportional hazard models showed an inverse correlation between miR-486-5p and PIK3R1 as well as a shorter time to recurrence after HCC resection in patients with lower miR-486-5p expression; Hence we conclude that miR-486-5p which is frequently downregulated in HCC inhibits HCC progression by targeting PIK3R1 and phosphatidylinositol 3-kinase-AKT activation recurrence;progression liver cancer hsa-miR-584-5p PIK3R1 0.589598947677312 0.0116529998851398 -0.896262231955658 0.000721334118501467 mirMAP -0.191521099652261 0.000371269579478526 NA NA NA hsa-miR-629-3p PIK3R1 2.65568346952191 8.96546275114201e-22 -0.896262231955658 0.000721334118501467 MirTarget -0.131802784507267 0.00329563191136515 NA NA NA hsa-miR-93-5p PIK3R1 2.57501728456111 3.73950852324834e-39 -0.896262231955658 0.000721334118501467 MirTarget;miRNATAP -0.169968852880897 0.00377299374941742 NA NA NA hsa-miR-30a-5p PIK3R2 0.204006364430255 0.420323839030139 0.785472268800114 2.5268888149325e-10 miRNATAP -0.0936779839366971 7.17655296402071e-05 NA NA NA hsa-miR-1271-5p PIK3R3 -0.42932619799753 0.0730879279909732 1.287677620125 1.56786114071875e-10 mirMAP -0.252421495183511 3.22875683299727e-10 NA NA NA hsa-miR-136-5p PIK3R3 -0.985471706280937 0.00106796270751475 1.287677620125 1.56786114071875e-10 mirMAP -0.0640060044447308 0.0472063344503429 NA NA NA hsa-miR-222-5p PIK3R3 0.0863587509728097 0.719399526083386 1.287677620125 1.56786114071875e-10 mirMAP -0.254483534842234 2.11287056050955e-10 NA NA NA hsa-miR-26a-5p PIK3R3 -0.631973911825762 2.12482912864596e-07 1.287677620125 1.56786114071875e-10 miRNATAP -0.413940763904974 1.80277478219919e-07 NA NA NA hsa-miR-29b-1-5p PIK3R3 0.186982580224589 0.373497464809179 1.287677620125 1.56786114071875e-10 mirMAP -0.202014476167499 1.29941894162278e-05 NA NA NA hsa-miR-32-5p PIK3R3 1.61585199704519 4.93530744182272e-20 1.287677620125 1.56786114071875e-10 MirTarget;miRNATAP -0.109163538678361 0.040304938355106 NA NA NA hsa-miR-326 PIK3R3 1.06977601173234 5.63826621091937e-05 1.287677620125 1.56786114071875e-10 miRanda -0.0774234966372294 0.0340444464407451 NA NA NA hsa-miR-335-3p PIK3R3 1.32116009044055 1.0694366259168e-09 1.287677620125 1.56786114071875e-10 mirMAP -0.148387962539259 0.000763673245030228 NA NA NA hsa-miR-369-3p PIK3R3 -0.26539037137152 0.339036790957306 1.287677620125 1.56786114071875e-10 PITA -0.0751174114595767 0.0337060860325762 NA NA NA hsa-miR-381-3p PIK3R3 -2.14901628446088 5.27985520315529e-16 1.287677620125 1.56786114071875e-10 mirMAP -0.145347278844516 3.84525180471706e-05 NA NA NA hsa-miR-485-3p PIK3R3 0.172730928363183 0.539248536084 1.287677620125 1.56786114071875e-10 PITA -0.0891992340118364 0.011316140912101 NA NA NA hsa-miR-495-3p PIK3R3 -1.0457993800949 0.000170722019961563 1.287677620125 1.56786114071875e-10 mirMAP -0.101013226218051 0.00389397238521848 NA NA NA hsa-miR-654-3p PIK3R3 -0.81291301584907 0.00361901812751347 1.287677620125 1.56786114071875e-10 PITA;miRNATAP -0.0789006422233835 0.0232464714998111 NA NA NA hsa-miR-708-3p PIK3R3 0.644085315651091 0.0313703367354351 1.287677620125 1.56786114071875e-10 mirMAP -0.0686268030369139 0.0348683647771477 NA NA NA hsa-miR-125b-5p PIK3R5 -1.41889699079623 1.55084253952861e-08 0.248077851657597 0.278337211215924 MirTarget -0.107457640642552 0.011496572760821 NA NA NA hsa-let-7a-3p PPP3CA 1.03029456575871 2.05932484675687e-08 -0.56464736676703 3.80642022630747e-05 MirTarget;miRNATAP -0.0717188066561765 0.0417396994388227 NA NA NA hsa-let-7e-5p PPP3CA 0.821771857232799 1.19334423679144e-10 -0.56464736676703 3.80642022630747e-05 miRNATAP -0.14532271789805 0.0042513156847095 NA NA NA hsa-let-7f-1-3p PPP3CA 0.993720810761227 6.0407149976796e-08 -0.56464736676703 3.80642022630747e-05 MirTarget -0.139823336802428 7.34966265195679e-05 NA NA NA hsa-let-7f-5p PPP3CA 0.266716939373151 0.0560684654270442 -0.56464736676703 3.80642022630747e-05 miRNATAP -0.111946419074163 0.0181785952636192 NA NA NA hsa-let-7g-5p PPP3CA 1.15803586058037 1.01768088555577e-12 -0.56464736676703 3.80642022630747e-05 miRNATAP -0.162454785609375 3.4429455491089e-05 NA NA NA hsa-let-7i-5p PPP3CA 0.158027124606232 0.194776988625516 -0.56464736676703 3.80642022630747e-05 miRNATAP -0.118132906706751 0.0307057179112106 NA NA NA hsa-miR-106a-5p PPP3CA 2.93836356285531 1.22956096158575e-21 -0.56464736676703 3.80642022630747e-05 miRNATAP -0.0636502293388956 0.00160889381904472 NA NA NA hsa-miR-106b-5p PPP3CA 2.17788294729604 3.35797658884941e-37 -0.56464736676703 3.80642022630747e-05 miRNATAP -0.174406271196721 5.73611941011346e-07 NA NA NA hsa-miR-142-3p PPP3CA 2.06949312533096 2.01386337282794e-15 -0.56464736676703 3.80642022630747e-05 miRNATAP -0.131032255699613 4.40327798850473e-08 NA NA NA hsa-miR-142-5p PPP3CA 1.99051987846668 1.30874707506504e-14 -0.56464736676703 3.80642022630747e-05 PITA;mirMAP;miRNATAP -0.149697869948015 5.10291739283988e-10 NA NA NA hsa-miR-17-5p PPP3CA 2.26819952852251 1.17080117367962e-29 -0.56464736676703 3.80642022630747e-05 miRNATAP -0.114596289079116 0.000162276601095922 NA NA NA hsa-miR-186-5p PPP3CA 1.01160002003511 1.0995153919986e-13 -0.56464736676703 3.80642022630747e-05 mirMAP -0.1503496256712 0.00141021570506968 NA NA NA hsa-miR-194-5p PPP3CA 1.35024465297519 5.96298080024074e-09 -0.56464736676703 3.80642022630747e-05 MirTarget -0.105560836203484 0.000130156114534005 NA NA NA hsa-miR-20a-5p PPP3CA 1.51276418035651 8.71307033346922e-13 -0.56464736676703 3.80642022630747e-05 miRNATAP -0.0603258884607931 0.045682807132728 NA NA NA hsa-miR-3065-3p PPP3CA 2.26276131398567 7.32764250522453e-13 -0.56464736676703 3.80642022630747e-05 miRNATAP -0.0594753585942102 0.00310925817651502 NA NA NA hsa-miR-3065-5p PPP3CA 2.75496955380748 2.37091362562179e-15 -0.56464736676703 3.80642022630747e-05 mirMAP;miRNATAP -0.0668606025718126 0.000440463413748686 NA NA NA hsa-miR-30a-5p PPP3CA 0.204006364430255 0.420323839030139 -0.56464736676703 3.80642022630747e-05 miRNAWalker2_validate;miRNATAP -0.0726820842056722 0.00491688909019515 NA NA NA hsa-miR-30c-5p PPP3CA 0.724673207831053 1.32226261564805e-05 -0.56464736676703 3.80642022630747e-05 miRNATAP -0.159718080807095 4.18949357482162e-05 NA NA NA hsa-miR-320a PPP3CA 0.502704491334741 0.00226252073794899 -0.56464736676703 3.80642022630747e-05 miRanda -0.107779582080368 0.00681079082384027 NA NA NA hsa-miR-320b PPP3CA 1.09552613515995 1.0755423833529e-07 -0.56464736676703 3.80642022630747e-05 miRanda -0.0820859147683515 0.00881393292048716 NA NA NA hsa-miR-335-3p PPP3CA 1.32116009044055 1.0694366259168e-09 -0.56464736676703 3.80642022630747e-05 MirTarget -0.117589497431174 6.74564637286435e-05 NA NA NA hsa-miR-338-5p PPP3CA 0.585864914585632 0.0447092071232699 -0.56464736676703 3.80642022630747e-05 miRNATAP -0.0605026582432578 0.00721382062074672 NA NA NA hsa-miR-33a-3p PPP3CA 1.39444251212239 7.26586547385458e-13 -0.56464736676703 3.80642022630747e-05 MirTarget;mirMAP;miRNATAP -0.155001049550257 2.15219083622203e-06 NA NA NA hsa-miR-340-5p PPP3CA 1.35294088371205 8.25205106713644e-16 -0.56464736676703 3.80642022630747e-05 mirMAP -0.0950376889898386 0.011977796828351 NA NA NA hsa-miR-501-3p PPP3CA 2.18792856444299 6.3664407099549e-25 -0.56464736676703 3.80642022630747e-05 MirTarget;PITA;miRNATAP -0.0647623462857793 0.0264755382118898 NA NA NA hsa-miR-590-3p PPP3CA 1.73212597984247 2.26504285146779e-20 -0.56464736676703 3.80642022630747e-05 miRanda;mirMAP -0.150969589493539 5.75882739473462e-06 NA NA NA hsa-miR-590-5p PPP3CA 1.45684002317639 1.74263571329047e-15 -0.56464736676703 3.80642022630747e-05 PITA;miRanda;miRNATAP -0.155074158109009 6.62335258985478e-06 NA NA NA hsa-miR-616-5p PPP3CA 1.97053352577988 6.50616168455898e-16 -0.56464736676703 3.80642022630747e-05 MirTarget;mirMAP;miRNATAP -0.0527805488262301 0.0430651294568523 NA NA NA hsa-miR-628-3p PPP3CA 0.967264135353398 1.20380730705551e-05 -0.56464736676703 3.80642022630747e-05 PITA -0.0679150038955295 0.0219290649289584 NA NA NA hsa-miR-7-1-3p PPP3CA 1.83538862227934 3.8339472676544e-18 -0.56464736676703 3.80642022630747e-05 MirTarget;mirMAP -0.0767121851790096 0.00998011752416248 NA NA NA hsa-miR-93-3p PPP3CA 2.61864344698618 2.94894843671131e-33 -0.56464736676703 3.80642022630747e-05 miRNATAP -0.0711145487492792 0.0105386285035473 NA NA NA hsa-miR-940 PPP3CA 3.48873734617979 1.86622896910559e-36 -0.56464736676703 3.80642022630747e-05 miRNATAP -0.0993469148626804 7.80527045628102e-06 NA NA NA hsa-miR-96-5p PPP3CA 5.73185523568009 7.6326624678818e-88 -0.56464736676703 3.80642022630747e-05 TargetScan -0.0819812567325419 7.62911983596639e-06 NA NA NA hsa-miR-99b-5p PPP3CA 0.749029504102012 1.12134590193157e-06 -0.56464736676703 3.80642022630747e-05 MirTarget -0.150845732488355 0.000353424950378474 NA NA NA hsa-miR-107 PPP3CB 1.80682322226628 2.47002735902976e-27 -0.862685645755972 9.92727029584851e-19 miRanda -0.0658992391569685 0.0154375879768625 NA NA NA hsa-miR-1254 PPP3CB 2.6936072043758 2.69365736193576e-22 -0.862685645755972 9.92727029584851e-19 MirTarget;PITA;miRNATAP -0.0595830676389443 0.000990315137221435 NA NA NA hsa-miR-146b-5p PPP3CB 1.31285313891779 3.27846083137877e-10 -0.862685645755972 9.92727029584851e-19 miRanda -0.0783898958349141 0.000498705699864243 NA NA NA hsa-miR-15a-5p PPP3CB 1.77791080875961 1.15367449842886e-31 -0.862685645755972 9.92727029584851e-19 miRNATAP -0.129410622080866 1.08204576642431e-05 NA NA NA hsa-miR-15b-5p PPP3CB 2.49680902955696 1.79560488884714e-45 -0.862685645755972 9.92727029584851e-19 miRNATAP -0.159596407532973 3.30586235216355e-11 NA NA NA hsa-miR-16-5p PPP3CB 1.88120757008208 1.6207082610779e-32 -0.862685645755972 9.92727029584851e-19 miRNATAP -0.189983863067775 6.55796862494601e-12 NA NA NA hsa-miR-20a-3p PPP3CB 1.64245855705225 5.21058119170445e-13 -0.862685645755972 9.92727029584851e-19 miRNATAP -0.0637593489639791 0.00190401589166746 NA NA NA hsa-miR-26b-5p PPP3CB 0.300594892480765 0.0431916558729258 -0.862685645755972 9.92727029584851e-19 MirTarget;miRNATAP -0.154671740383362 1.6938587250365e-06 NA NA NA hsa-miR-3065-5p PPP3CB 2.75496955380748 2.37091362562179e-15 -0.862685645755972 9.92727029584851e-19 mirMAP -0.0738853021387918 9.63023928857933e-08 NA NA NA hsa-miR-30c-5p PPP3CB 0.724673207831053 1.32226261564805e-05 -0.862685645755972 9.92727029584851e-19 miRNATAP -0.148606458797586 1.80925082785315e-07 NA NA NA hsa-miR-30d-5p PPP3CB 0.577677794903206 0.000226725362226714 -0.862685645755972 9.92727029584851e-19 miRNATAP -0.0638404679805377 0.0380235554335775 NA NA NA hsa-miR-320a PPP3CB 0.502704491334741 0.00226252073794899 -0.862685645755972 9.92727029584851e-19 miRanda -0.0979520225621702 0.000796076959675217 NA NA NA hsa-miR-320b PPP3CB 1.09552613515995 1.0755423833529e-07 -0.862685645755972 9.92727029584851e-19 miRanda -0.0894699759568552 9.4818266714561e-05 NA NA NA hsa-miR-320c PPP3CB 0.733362580458909 0.00057735467707277 -0.862685645755972 9.92727029584851e-19 miRanda -0.0725905744112011 0.00158017557425748 NA NA NA hsa-miR-326 PPP3CB 1.06977601173234 5.63826621091937e-05 -0.862685645755972 9.92727029584851e-19 MirTarget;PITA;miRanda -0.0881705688267062 7.37758739563029e-07 NA NA NA hsa-miR-330-5p PPP3CB 2.22118657747194 1.60999465282299e-26 -0.862685645755972 9.92727029584851e-19 MirTarget;PITA;miRanda -0.155447730751201 2.05875430963714e-13 NA NA NA hsa-miR-339-5p PPP3CB 1.79341790518551 3.04346641619717e-17 -0.862685645755972 9.92727029584851e-19 miRanda -0.141903148086984 3.11421085989714e-11 NA NA NA hsa-miR-340-5p PPP3CB 1.35294088371205 8.25205106713644e-16 -0.862685645755972 9.92727029584851e-19 MirTarget -0.0862414013748357 0.00187717374127515 NA NA NA hsa-miR-342-3p PPP3CB 0.909988426908683 3.51879055202261e-09 -0.862685645755972 9.92727029584851e-19 miRanda -0.171936537748962 1.63170446344545e-08 NA NA NA hsa-miR-421 PPP3CB 2.10188043858202 8.21949037851434e-21 -0.862685645755972 9.92727029584851e-19 miRanda -0.0912547195548902 7.64678096851224e-06 NA NA NA hsa-miR-429 PPP3CB 5.03984117897747 4.44936205318976e-55 -0.862685645755972 9.92727029584851e-19 miRanda -0.100601436632065 1.92267096642331e-15 NA NA NA hsa-miR-501-5p PPP3CB 1.63365089104021 2.93689344466334e-15 -0.862685645755972 9.92727029584851e-19 PITA;miRNATAP -0.0609839584380024 0.00679202409370566 NA NA NA hsa-miR-577 PPP3CB 3.23403680126545 4.85573112916202e-14 -0.862685645755972 9.92727029584851e-19 mirMAP -0.0570249424887336 1.79820134348582e-07 NA NA NA hsa-miR-590-3p PPP3CB 1.73212597984247 2.26504285146779e-20 -0.862685645755972 9.92727029584851e-19 miRanda -0.165219959788061 7.13164339473802e-12 NA NA NA hsa-miR-628-3p PPP3CB 0.967264135353398 1.20380730705551e-05 -0.862685645755972 9.92727029584851e-19 MirTarget;PITA -0.0792705448641079 0.000255400896124562 NA NA NA hsa-miR-7-1-3p PPP3CB 1.83538862227934 3.8339472676544e-18 -0.862685645755972 9.92727029584851e-19 mirMAP -0.117851670871222 4.82962659233713e-08 NA NA NA hsa-miR-361-5p PPP3CC 0.505614361096266 0.000106749108296893 -0.65928774812974 9.42082421531364e-05 miRanda -0.169437553270436 0.00638999993263443 NA NA NA hsa-let-7g-3p PPP3R1 1.65665608943609 2.34494456080924e-14 -0.23967155518578 0.0300433371313214 miRNATAP -0.0854409570366323 0.000242181371482742 NA NA NA hsa-miR-142-3p PPP3R1 2.06949312533096 2.01386337282794e-15 -0.23967155518578 0.0300433371313214 miRanda;miRNATAP -0.0896281214385923 3.08591577358727e-06 NA NA NA hsa-miR-142-5p PPP3R1 1.99051987846668 1.30874707506504e-14 -0.23967155518578 0.0300433371313214 PITA -0.106425879970049 3.67891541060512e-08 NA NA NA hsa-miR-182-5p PPP3R1 5.17636717835373 1.04663621342014e-76 -0.23967155518578 0.0300433371313214 MirTarget;miRNATAP -0.0520115504243797 0.000842830490633652 NA NA NA hsa-miR-26a-5p PPP3R1 -0.631973911825762 2.12482912864596e-07 -0.23967155518578 0.0300433371313214 MirTarget;miRNATAP -0.0889613661500985 0.0389015933084931 NA NA NA hsa-miR-26b-5p PPP3R1 0.300594892480765 0.0431916558729258 -0.23967155518578 0.0300433371313214 miRNAWalker2_validate;MirTarget;miRNATAP -0.170609967959353 1.18360220973137e-06 NA NA NA hsa-miR-30a-5p PPP3R1 0.204006364430255 0.420323839030139 -0.23967155518578 0.0300433371313214 miRNAWalker2_validate;MirTarget;miRNATAP -0.0579251882832828 0.00502417664934802 NA NA NA hsa-miR-30b-5p PPP3R1 0.359198073795339 0.0288588301689338 -0.23967155518578 0.0300433371313214 MirTarget -0.131617861822401 3.4536538693276e-05 NA NA NA hsa-miR-30c-5p PPP3R1 0.724673207831053 1.32226261564805e-05 -0.23967155518578 0.0300433371313214 MirTarget;miRNATAP -0.133820649764201 1.7036654663713e-05 NA NA NA hsa-miR-320a PPP3R1 0.502704491334741 0.00226252073794899 -0.23967155518578 0.0300433371313214 PITA;miRanda -0.14598974876965 3.75795017544667e-06 NA NA NA hsa-miR-320b PPP3R1 1.09552613515995 1.0755423833529e-07 -0.23967155518578 0.0300433371313214 PITA;miRanda -0.0546425024132298 0.0292766432752025 NA NA NA hsa-miR-33a-3p PPP3R1 1.39444251212239 7.26586547385458e-13 -0.23967155518578 0.0300433371313214 MirTarget -0.106520988837526 4.85607122716404e-05 NA NA NA hsa-miR-342-3p PPP3R1 0.909988426908683 3.51879055202261e-09 -0.23967155518578 0.0300433371313214 MirTarget;miRanda;miRNATAP -0.177606025127503 8.52703934980085e-08 NA NA NA hsa-miR-34a-5p PPP3R1 0.944430336151223 7.7422387648004e-06 -0.23967155518578 0.0300433371313214 miRNAWalker2_validate -0.0883446700521493 0.000304906179832168 NA NA NA hsa-miR-532-3p PPP3R1 1.39711438989287 4.70050755096321e-15 -0.23967155518578 0.0300433371313214 miRNAWalker2_validate -0.108097769922526 0.000138419841438524 NA NA NA hsa-miR-590-3p PPP3R1 1.73212597984247 2.26504285146779e-20 -0.23967155518578 0.0300433371313214 miRanda;mirMAP -0.0926270220089899 0.000528236078262347 NA NA NA hsa-miR-7-1-3p PPP3R1 1.83538862227934 3.8339472676544e-18 -0.23967155518578 0.0300433371313214 MirTarget -0.0576124474989596 0.0154792653556513 NA NA NA hsa-let-7a-3p PRKACB 1.03029456575871 2.05932484675687e-08 -1.28945064071622 4.1282448373482e-14 MirTarget;mirMAP;miRNATAP -0.206773631123232 3.28324195088026e-06 NA NA NA hsa-let-7b-3p PRKACB 0.348643846906648 0.0705621714966111 -1.28945064071622 4.1282448373482e-14 MirTarget;mirMAP;miRNATAP -0.129911431281918 0.00270370963261393 NA NA NA hsa-let-7d-3p PRKACB 1.44093882852129 4.04763272848201e-19 -1.28945064071622 4.1282448373482e-14 MirTarget -0.280272112199815 1.16328593124147e-08 NA NA NA hsa-let-7f-1-3p PRKACB 0.993720810761227 6.0407149976796e-08 -1.28945064071622 4.1282448373482e-14 MirTarget;mirMAP -0.209406259366502 2.93221286196806e-06 NA NA NA hsa-miR-141-3p PRKACB 4.68123467996176 4.92783859837668e-50 -1.28945064071622 4.1282448373482e-14 MirTarget;TargetScan;miRNATAP -0.213001699206336 2.13565852831898e-21 NA NA NA hsa-miR-16-2-3p PRKACB 2.33811104285535 7.35637935757058e-33 -1.28945064071622 4.1282448373482e-14 mirMAP -0.286032449648446 1.09784260370984e-13 NA NA NA hsa-miR-17-5p PRKACB 2.26819952852251 1.17080117367962e-29 -1.28945064071622 4.1282448373482e-14 TargetScan -0.165119053453845 1.91962959533113e-05 NA NA NA hsa-miR-182-5p PRKACB 5.17636717835373 1.04663621342014e-76 -1.28945064071622 4.1282448373482e-14 MirTarget;miRNATAP -0.206511369646811 7.49944771244656e-18 NA NA NA hsa-miR-183-5p PRKACB 6.01612233013103 1.47372794176386e-93 -1.28945064071622 4.1282448373482e-14 MirTarget -0.186076630420368 3.1196817269174e-17 NA NA NA hsa-miR-18a-5p PRKACB 3.22282140470889 1.9203457351048e-39 -1.28945064071622 4.1282448373482e-14 miRNATAP -0.172950527379836 1.53436386357174e-08 NA NA NA hsa-miR-193a-3p PRKACB 0.422281760608533 0.0531653219715062 -1.28945064071622 4.1282448373482e-14 miRanda -0.112613713652144 0.00320201811689587 NA NA NA hsa-miR-194-3p PRKACB 2.11147094894143 4.71008121765196e-13 -1.28945064071622 4.1282448373482e-14 MirTarget -0.113390840021951 5.76626202674488e-05 NA NA NA hsa-miR-19a-3p PRKACB 1.84830198357993 2.4710712042826e-20 -1.28945064071622 4.1282448373482e-14 MirTarget;miRNATAP -0.161702323364434 4.59373068250418e-05 NA NA NA hsa-miR-19b-3p PRKACB 1.34004947278979 5.26920324973452e-16 -1.28945064071622 4.1282448373482e-14 miRNAWalker2_validate;MirTarget;miRNATAP -0.205566362483884 2.40161324794384e-05 NA NA NA hsa-miR-200a-3p PRKACB 4.83505960801065 7.294437616154e-52 -1.28945064071622 4.1282448373482e-14 MirTarget;miRNATAP -0.199132574957824 2.34107342599864e-19 NA NA NA hsa-miR-200b-3p PRKACB 4.56508753729609 3.8956399692993e-55 -1.28945064071622 4.1282448373482e-14 MirTarget;TargetScan -0.222124326966506 1.8416438051642e-20 NA NA NA hsa-miR-200c-3p PRKACB 4.19740435353621 6.07734417092297e-49 -1.28945064071622 4.1282448373482e-14 MirTarget;miRNATAP -0.221962495763482 5.880947543872e-19 NA NA NA hsa-miR-2110 PRKACB 1.57021301515342 7.33611160219404e-14 -1.28945064071622 4.1282448373482e-14 MirTarget -0.157738211684051 4.83287023242134e-05 NA NA NA hsa-miR-3065-5p PRKACB 2.75496955380748 2.37091362562179e-15 -1.28945064071622 4.1282448373482e-14 MirTarget -0.103283203858535 1.91517065139659e-05 NA NA NA hsa-miR-30d-3p PRKACB 0.755916398923689 3.64952022092868e-05 -1.28945064071622 4.1282448373482e-14 mirMAP -0.12280212564852 0.00682452570522386 NA NA NA hsa-miR-30e-3p PRKACB 0.124986008379077 0.345651708234895 -1.28945064071622 4.1282448373482e-14 mirMAP -0.12809210352011 0.0450071179806954 NA NA NA hsa-miR-32-3p PRKACB 2.40467177052961 5.81388257063569e-26 -1.28945064071622 4.1282448373482e-14 mirMAP;miRNATAP -0.209502038433714 8.89230588638245e-09 NA NA NA hsa-miR-330-3p PRKACB 1.76420587112262 1.73634190017122e-17 -1.28945064071622 4.1282448373482e-14 MirTarget -0.107703931100094 0.0055340466472889 NA NA NA hsa-miR-339-5p PRKACB 1.79341790518551 3.04346641619717e-17 -1.28945064071622 4.1282448373482e-14 miRanda -0.206244746428091 3.32354056095382e-08 NA NA NA hsa-miR-340-5p PRKACB 1.35294088371205 8.25205106713644e-16 -1.28945064071622 4.1282448373482e-14 mirMAP -0.104657250446656 0.0300506989994588 NA NA NA hsa-miR-429 PRKACB 5.03984117897747 4.44936205318976e-55 -1.28945064071622 4.1282448373482e-14 MirTarget;PITA;miRanda;miRNATAP -0.199780578332516 3.30833090844044e-20 NA NA NA hsa-miR-548v PRKACB 1.69887322011149 1.0523433577007e-09 -1.28945064071622 4.1282448373482e-14 MirTarget -0.0652295311587177 0.0283168760673161 NA NA NA hsa-miR-577 PRKACB 3.23403680126545 4.85573112916202e-14 -1.28945064071622 4.1282448373482e-14 PITA -0.0611605861321828 0.0013893640731974 NA NA NA hsa-miR-590-3p PRKACB 1.73212597984247 2.26504285146779e-20 -1.28945064071622 4.1282448373482e-14 MirTarget;PITA;miRanda;miRNATAP -0.186139517924745 1.16298924864699e-05 NA NA NA hsa-miR-590-5p PRKACB 1.45684002317639 1.74263571329047e-15 -1.28945064071622 4.1282448373482e-14 miRanda -0.186018314679657 2.2824170701112e-05 NA NA NA hsa-miR-616-5p PRKACB 1.97053352577988 6.50616168455898e-16 -1.28945064071622 4.1282448373482e-14 mirMAP -0.144518937874829 1.16442583315498e-05 NA NA NA hsa-miR-7-1-3p PRKACB 1.83538862227934 3.8339472676544e-18 -1.28945064071622 4.1282448373482e-14 mirMAP -0.153887850371878 4.52630709577869e-05 NA NA NA hsa-miR-93-5p PRKACB 2.57501728456111 3.73950852324834e-39 -1.28945064071622 4.1282448373482e-14 miRNAWalker2_validate -0.126790981527391 0.00103788824319385 NA NA NA hsa-miR-96-5p PRKACB 5.73185523568009 7.6326624678818e-88 -1.28945064071622 4.1282448373482e-14 miRNATAP -0.208501454058424 1.95842230666746e-20 NA NA NA hsa-miR-107 PRKAR1A 1.80682322226628 2.47002735902976e-27 -0.941032683750463 5.06599068780342e-18 miRanda -0.151634569596039 4.15002421296886e-07 NA NA NA hsa-miR-10a-3p PRKAR1A 2.65415484977961 4.06781213095544e-14 -0.941032683750463 5.06599068780342e-18 miRNATAP -0.0802191466468365 7.50277524506038e-08 NA NA NA hsa-miR-1296-5p PRKAR1A 0.806534074522919 0.000101730973737677 -0.941032683750463 5.06599068780342e-18 miRNAWalker2_validate -0.132315294027152 1.88962839967164e-07 NA NA NA hsa-miR-141-3p PRKAR1A 4.68123467996176 4.92783859837668e-50 -0.941032683750463 5.06599068780342e-18 TargetScan -0.129324086243144 4.18037522097689e-19 NA NA NA hsa-miR-155-5p PRKAR1A 2.19935449503549 2.51453237821502e-16 -0.941032683750463 5.06599068780342e-18 miRNAWalker2_validate -0.132435330133173 1.66577321345963e-12 NA NA NA hsa-miR-16-2-3p PRKAR1A 2.33811104285535 7.35637935757058e-33 -0.941032683750463 5.06599068780342e-18 mirMAP -0.223727260974171 3.58320469888939e-20 NA NA NA hsa-miR-16-5p PRKAR1A 1.88120757008208 1.6207082610779e-32 -0.941032683750463 5.06599068780342e-18 miRNAWalker2_validate -0.275414027911041 7.36420731878768e-20 NA NA NA hsa-miR-182-5p PRKAR1A 5.17636717835373 1.04663621342014e-76 -0.941032683750463 5.06599068780342e-18 miRNATAP -0.148549123456534 1.7189916137891e-22 NA NA NA hsa-miR-186-5p PRKAR1A 1.01160002003511 1.0995153919986e-13 -0.941032683750463 5.06599068780342e-18 mirMAP -0.293652918375898 4.34420938992171e-15 NA NA NA hsa-miR-192-5p PRKAR1A 1.9768050798781 2.15983442827314e-13 -0.941032683750463 5.06599068780342e-18 miRNAWalker2_validate -0.0790177678138051 3.78181641697229e-05 NA NA NA hsa-miR-200b-3p PRKAR1A 4.56508753729609 3.8956399692993e-55 -0.941032683750463 5.06599068780342e-18 TargetScan -0.11870003138184 2.99661112624357e-14 NA NA NA hsa-miR-215-5p PRKAR1A 2.37852263788145 7.93880971902919e-16 -0.941032683750463 5.06599068780342e-18 miRNAWalker2_validate -0.0795617045280684 4.68149535555633e-06 NA NA NA hsa-miR-25-3p PRKAR1A 1.36338550911959 2.27429614057655e-21 -0.941032683750463 5.06599068780342e-18 miRNAWalker2_validate -0.207657420385444 3.90819777765975e-09 NA NA NA hsa-miR-30b-5p PRKAR1A 0.359198073795339 0.0288588301689338 -0.941032683750463 5.06599068780342e-18 mirMAP -0.156702745842845 1.35131530502476e-06 NA NA NA hsa-miR-30c-5p PRKAR1A 0.724673207831053 1.32226261564805e-05 -0.941032683750463 5.06599068780342e-18 mirMAP -0.14003884225509 1.09664229764196e-05 NA NA NA hsa-miR-30e-5p PRKAR1A 0.264119434405151 0.0488892309487705 -0.941032683750463 5.06599068780342e-18 mirMAP -0.0907381827781405 0.0248065229796652 NA NA NA hsa-miR-32-3p PRKAR1A 2.40467177052961 5.81388257063569e-26 -0.941032683750463 5.06599068780342e-18 mirMAP -0.197487158666977 5.51848636502437e-18 NA NA NA hsa-miR-320a PRKAR1A 0.502704491334741 0.00226252073794899 -0.941032683750463 5.06599068780342e-18 miRanda -0.226662553762505 1.01677545457078e-12 NA NA NA hsa-miR-320b PRKAR1A 1.09552613515995 1.0755423833529e-07 -0.941032683750463 5.06599068780342e-18 miRanda -0.158724790380511 2.85137991765985e-10 NA NA NA hsa-miR-320c PRKAR1A 0.733362580458909 0.00057735467707277 -0.941032683750463 5.06599068780342e-18 miRanda -0.135921730514751 7.83720354439614e-08 NA NA NA hsa-miR-324-3p PRKAR1A 2.34606663412817 2.38165582241626e-31 -0.941032683750463 5.06599068780342e-18 miRNAWalker2_validate -0.156149903020152 1.24343810405852e-10 NA NA NA hsa-miR-342-3p PRKAR1A 0.909988426908683 3.51879055202261e-09 -0.941032683750463 5.06599068780342e-18 miRanda -0.235505433708412 2.29146104472588e-12 NA NA NA hsa-miR-429 PRKAR1A 5.03984117897747 4.44936205318976e-55 -0.941032683750463 5.06599068780342e-18 PITA;miRanda;miRNATAP -0.117674926929266 5.20688319242296e-17 NA NA NA hsa-miR-577 PRKAR1A 3.23403680126545 4.85573112916202e-14 -0.941032683750463 5.06599068780342e-18 PITA;mirMAP -0.0671309533055375 3.21814595001069e-08 NA NA NA hsa-miR-590-3p PRKAR1A 1.73212597984247 2.26504285146779e-20 -0.941032683750463 5.06599068780342e-18 miRanda;mirMAP -0.202742869477114 2.93072597793602e-14 NA NA NA hsa-miR-590-5p PRKAR1A 1.45684002317639 1.74263571329047e-15 -0.941032683750463 5.06599068780342e-18 miRanda -0.208517835947033 4.03891882379155e-14 NA NA NA hsa-miR-616-5p PRKAR1A 1.97053352577988 6.50616168455898e-16 -0.941032683750463 5.06599068780342e-18 mirMAP -0.104424248942301 7.44253109065304e-07 NA NA NA hsa-miR-96-5p PRKAR1A 5.73185523568009 7.6326624678818e-88 -0.941032683750463 5.06599068780342e-18 miRNAWalker2_validate;TargetScan;miRNATAP -0.138032880824777 9.13391108558646e-22 NA NA NA hsa-miR-32-5p PRKAR1B 1.61585199704519 4.93530744182272e-20 -0.792915934460223 1.18911063494161e-07 miRNATAP -0.0915078522588633 0.0197454987016746 NA NA NA hsa-miR-92b-3p PRKAR1B 2.30712626248952 3.58511983194853e-19 -0.792915934460223 1.18911063494161e-07 miRNATAP -0.102803525240314 0.000110605167575876 NA NA NA hsa-miR-103a-3p PRKAR2A 1.51214214201065 3.45388560860799e-21 -0.317965220944231 0.197511727742495 miRNAWalker2_validate -0.161006797637028 0.0217798621840546 NA NA NA hsa-miR-106b-5p PRKAR2A 2.17788294729604 3.35797658884941e-37 -0.317965220944231 0.197511727742495 mirMAP -0.317140555443344 3.64402662845876e-07 NA NA NA hsa-miR-155-5p PRKAR2A 2.19935449503549 2.51453237821502e-16 -0.317965220944231 0.197511727742495 miRNAWalker2_validate -0.101966897948916 0.0152665232584048 NA NA NA hsa-miR-17-5p PRKAR2A 2.26819952852251 1.17080117367962e-29 -0.317965220944231 0.197511727742495 mirMAP -0.10884378113339 0.046418507945122 NA NA NA hsa-miR-20a-5p PRKAR2A 1.51276418035651 8.71307033346922e-13 -0.317965220944231 0.197511727742495 mirMAP -0.148383080218247 0.00588340501761958 NA NA NA hsa-miR-25-3p PRKAR2A 1.36338550911959 2.27429614057655e-21 -0.317965220944231 0.197511727742495 mirMAP -0.174257266199637 0.0262309410280324 NA NA NA hsa-miR-26a-5p PRKAR2A -0.631973911825762 2.12482912864596e-07 -0.317965220944231 0.197511727742495 mirMAP -0.276494156340082 0.00405119630470102 NA NA NA hsa-miR-32-5p PRKAR2A 1.61585199704519 4.93530744182272e-20 -0.317965220944231 0.197511727742495 mirMAP -0.200024333091374 0.00168098411117131 NA NA NA hsa-miR-320a PRKAR2A 0.502704491334741 0.00226252073794899 -0.317965220944231 0.197511727742495 mirMAP -0.141773668591105 0.0469624538444595 NA NA NA hsa-miR-320b PRKAR2A 1.09552613515995 1.0755423833529e-07 -0.317965220944231 0.197511727742495 mirMAP -0.154378628241359 0.00585632686421551 NA NA NA hsa-miR-320c PRKAR2A 0.733362580458909 0.00057735467707277 -0.317965220944231 0.197511727742495 mirMAP -0.177845290719061 0.00146749407447825 NA NA NA hsa-miR-330-3p PRKAR2A 1.76420587112262 1.73634190017122e-17 -0.317965220944231 0.197511727742495 mirMAP -0.129054767398542 0.0179793610217987 NA NA NA hsa-miR-335-5p PRKAR2A 0.348427694169649 0.0962171361436908 -0.317965220944231 0.197511727742495 mirMAP -0.168690624006446 0.00253815690020926 NA NA NA hsa-miR-361-5p PRKAR2A 0.505614361096266 0.000106749108296893 -0.317965220944231 0.197511727742495 miRanda -0.21618008065109 0.016659648671412 NA NA NA hsa-miR-3913-5p PRKAR2A 0.368017617038804 0.0353860818102689 -0.317965220944231 0.197511727742495 mirMAP -0.19696602860131 0.00336349337445716 NA NA NA hsa-miR-421 PRKAR2A 2.10188043858202 8.21949037851434e-21 -0.317965220944231 0.197511727742495 mirMAP -0.138386837337557 0.00562144156443062 NA NA NA hsa-miR-92a-3p PRKAR2A 1.69110879028255 8.04580501722806e-26 -0.317965220944231 0.197511727742495 mirMAP -0.141045579090466 0.0409746278714756 NA NA NA hsa-let-7a-3p PRKAR2B 1.03029456575871 2.05932484675687e-08 -2.60149376066176 5.57630963579684e-18 mirMAP -0.484789280691252 6.78461858789382e-10 NA NA NA hsa-let-7b-3p PRKAR2B 0.348643846906648 0.0705621714966111 -2.60149376066176 5.57630963579684e-18 mirMAP -0.358966781738827 2.86705629964165e-06 NA NA NA hsa-let-7f-1-3p PRKAR2B 0.993720810761227 6.0407149976796e-08 -2.60149376066176 5.57630963579684e-18 mirMAP -0.450839958791539 1.38140242071339e-08 NA NA NA hsa-miR-107 PRKAR2B 1.80682322226628 2.47002735902976e-27 -2.60149376066176 5.57630963579684e-18 miRanda -0.440148403533987 1.19296111965405e-07 NA NA NA hsa-miR-186-5p PRKAR2B 1.01160002003511 1.0995153919986e-13 -2.60149376066176 5.57630963579684e-18 mirMAP -0.608592189459727 8.481956039551e-09 NA NA NA hsa-miR-200b-3p PRKAR2B 4.56508753729609 3.8956399692993e-55 -2.60149376066176 5.57630963579684e-18 TargetScan -0.395003220775076 2.48780079737642e-20 NA NA NA hsa-miR-200c-3p PRKAR2B 4.19740435353621 6.07734417092297e-49 -2.60149376066176 5.57630963579684e-18 miRNATAP -0.357924473400651 1.57305630511201e-15 NA NA NA hsa-miR-3065-5p PRKAR2B 2.75496955380748 2.37091362562179e-15 -2.60149376066176 5.57630963579684e-18 miRNATAP -0.127975721328848 0.00314613142441835 NA NA NA hsa-miR-32-5p PRKAR2B 1.61585199704519 4.93530744182272e-20 -2.60149376066176 5.57630963579684e-18 miRNATAP -0.377708176250432 2.6196324791752e-06 NA NA NA hsa-miR-335-3p PRKAR2B 1.32116009044055 1.0694366259168e-09 -2.60149376066176 5.57630963579684e-18 mirMAP -0.133812579214055 0.0475486289255819 NA NA NA hsa-miR-362-3p PRKAR2B 0.538723455753891 0.00242035379543243 -2.60149376066176 5.57630963579684e-18 miRanda -0.235460625431765 0.00504869575649551 NA NA NA hsa-miR-429 PRKAR2B 5.03984117897747 4.44936205318976e-55 -2.60149376066176 5.57630963579684e-18 PITA;miRanda;miRNATAP -0.34525486600178 5.95892083351336e-19 NA NA NA hsa-miR-590-3p PRKAR2B 1.73212597984247 2.26504285146779e-20 -2.60149376066176 5.57630963579684e-18 miRNAWalker2_validate;miRanda -0.411897340725988 4.46178732307498e-08 NA NA NA hsa-miR-9-5p PRKAR2B 2.38651876502552 5.41791811050795e-08 -2.60149376066176 5.57630963579684e-18 miRNATAP -0.167527595209389 3.52323972548921e-07 NA NA NA hsa-miR-92a-3p PRKAR2B 1.69110879028255 8.04580501722806e-26 -2.60149376066176 5.57630963579684e-18 miRNATAP -0.477578535224896 3.292288458246e-08 NA NA NA hsa-miR-92b-3p PRKAR2B 2.30712626248952 3.58511983194853e-19 -2.60149376066176 5.57630963579684e-18 miRNATAP -0.202461305998403 0.000233003739670312 NA NA NA hsa-miR-139-5p PRKX -2.41416537859302 6.88706484174732e-28 0.871634648208108 2.21869987291646e-07 MirTarget -0.0734175742743074 0.0330063339970823 NA NA NA hsa-miR-432-5p PRKX -0.400855766234494 0.173868609709397 0.871634648208108 2.21869987291646e-07 miRNATAP -0.0641454986968747 0.0206275685413973 NA NA NA hsa-miR-450b-5p PRKX -1.58457641368314 2.36571842796199e-11 0.871634648208108 2.21869987291646e-07 mirMAP -0.0894677997656537 0.00720041613692373 NA NA NA hsa-miR-542-3p PRKX -2.02613612825205 8.22372377712865e-20 0.871634648208108 2.21869987291646e-07 mirMAP -0.0911270116934023 0.00880851391130411 NA NA NA hsa-miR-374a-3p RIPK1 0.0941875095170328 0.532789406241938 -0.23073270765284 0.00263972293197785 mirMAP -0.0829315780823252 0.000594801114167766 NA NA NA hsa-miR-590-3p RIPK1 1.73212597984247 2.26504285146779e-20 -0.23073270765284 0.00263972293197785 MirTarget;miRanda -0.0611242247299421 0.000967449180130374 NA NA NA hsa-miR-140-5p TNF -0.887888681168421 5.76545563709515e-08 1.73368703853458 6.05412935266547e-06 miRanda -0.241406372358897 0.0302931135054523 NA NA NA hsa-miR-542-3p TNF -2.02613612825205 8.22372377712865e-20 1.73368703853458 6.05412935266547e-06 miRanda -0.204417378617075 0.00973745428965109 NA NA NA hsa-miR-654-3p TNF -0.81291301584907 0.00361901812751347 1.73368703853458 6.05412935266547e-06 miRNATAP -0.169378440845714 0.00966335078248652 NA NA NA hsa-miR-129-5p TNFRSF10A -0.708703178674802 0.0229981913632488 0.834875169024293 0.000806344462608793 miRanda -0.194597864611362 2.41423599318535e-07 NA NA NA hsa-miR-26a-5p TNFRSF10B -0.631973911825762 2.12482912864596e-07 0.822199658997421 8.1142816616948e-08 mirMAP -0.275543424183851 4.62817286518087e-06 NA NA NA hsa-miR-28-5p TNFRSF10B -0.466180213899448 0.00012482099258297 0.822199658997421 8.1142816616948e-08 miRanda -0.124496389514824 0.0423064577948475 NA NA NA hsa-miR-30a-5p TNFRSF10B 0.204006364430255 0.420323839030139 0.822199658997421 8.1142816616948e-08 miRNAWalker2_validate -0.0740262662521168 0.0110400967942241 NA NA NA hsa-miR-542-3p TNFRSF10B -2.02613612825205 8.22372377712865e-20 0.822199658997421 8.1142816616948e-08 miRanda -0.103564310329005 0.00106316058467598 NA NA NA hsa-miR-361-5p TNFRSF10C 0.505614361096266 0.000106749108296893 0.612603504450873 0.0379413018585382 miRanda -0.472082225864023 1.1011255942719e-05 NA NA NA hsa-miR-186-5p TNFRSF10D 1.01160002003511 1.0995153919986e-13 -0.700982177261642 0.0044295887940253 mirMAP -0.208548674766503 0.013669619190638 NA NA NA hsa-miR-26b-5p TNFRSF10D 0.300594892480765 0.0431916558729258 -0.700982177261642 0.0044295887940253 mirMAP -0.188319938661372 0.0179313194748026 NA NA NA hsa-miR-32-3p TNFRSF10D 2.40467177052961 5.81388257063569e-26 -0.700982177261642 0.0044295887940253 mirMAP -0.104154934577736 0.0454595463229443 NA NA NA hsa-miR-335-5p TNFRSF10D 0.348427694169649 0.0962171361436908 -0.700982177261642 0.0044295887940253 miRNAWalker2_validate -0.211734604381043 0.000148829241890216 NA NA NA hsa-miR-339-5p TNFRSF10D 1.79341790518551 3.04346641619717e-17 -0.700982177261642 0.0044295887940253 miRanda -0.15869631299905 0.00282360036120964 NA NA NA hsa-miR-340-5p TNFRSF10D 1.35294088371205 8.25205106713644e-16 -0.700982177261642 0.0044295887940253 mirMAP -0.272927404492713 5.10913314191292e-05 NA NA NA hsa-miR-590-3p TNFRSF10D 1.73212597984247 2.26504285146779e-20 -0.700982177261642 0.0044295887940253 miRanda -0.135807924289556 0.0240010455882798 NA NA NA hsa-miR-766-3p TNFRSF1A 2.69859152586189 7.66286160573257e-37 -0.282267810893869 0.00400036946090671 MirTarget -0.0551402522937801 0.00589942958110495 NA NA NA hsa-miR-33a-3p TNFSF10 1.39444251212239 7.26586547385458e-13 -0.13436119732381 0.609404902679058 mirMAP -0.244352458376869 9.37748218709432e-05 NA NA NA hsa-miR-590-3p TNFSF10 1.73212597984247 2.26504285146779e-20 -0.13436119732381 0.609404902679058 miRanda -0.133350947286517 0.037163819646835 NA NA NA hsa-miR-221-3p TP53 -0.456639894528899 0.0246851454601987 0.498837102942024 0.00520255799128458 miRNAWalker2_validate -0.091488148595158 0.0287514823805062 20880178;24324033 Circulating miR 221 directly amplified from plasma is a potential diagnostic and prognostic marker of colorectal cancer and is correlated with p53 expression; The correlation between miR-221 levels and protein levels of p53 CEA ER and PR clinicopathological features or overall survival was analyzed; The immunohistochemistry analysis demonstrates a significant correlation between plasma miR-221 level and p53 expression; The direct amplification of plasma miR-221 can be used as a potential noninvasive molecular marker for diagnosis and prognosis of CRC and is correlated with p53 expression;Interestingly miR-221 can activate the p53/mdm2 axis by inhibiting MDM2 and in turn p53 activation contributes to miR-221 enhanced expression; Moreover by modulating the p53 axis miR-221 impacts cell-cycle progression and apoptotic response to doxorubicin in hepatocellular carcinoma-derived cell lines; These data were confirmed in clinical specimens of hepatocellular carcinoma in which elevated miR-221 expression was associated with the simultaneous presence of wild-type p53 and DNA hypomethylation poor survival;worse prognosis;progression;drug resistance colorectal cancer;liver cancer hsa-miR-30d-5p TP53 0.577677794903206 0.000226725362226714 0.498837102942024 0.00520255799128458 miRNAWalker2_validate -0.172511137240746 0.00144218092065489 NA NA NA hsa-miR-338-3p TP53 0.429940853175601 0.097699268368127 0.498837102942024 0.00520255799128458 miRanda -0.0726314438617781 0.0263381634607685 NA NA NA hsa-miR-125a-3p TRADD 0.766248892008454 5.97048811423325e-05 -0.079472460020348 0.583422963204107 miRanda -0.122954584510496 0.000570659347386363 NA NA NA hsa-miR-320b TRADD 1.09552613515995 1.0755423833529e-07 -0.079472460020348 0.583422963204107 miRanda -0.079294363590423 0.0157856842457972 NA NA NA hsa-miR-324-3p TRADD 2.34606663412817 2.38165582241626e-31 -0.079472460020348 0.583422963204107 miRNATAP -0.102298394665137 0.00121685650450658 NA NA NA hsa-miR-214-5p TRAF2 -0.470625857505263 0.0712891374736165 0.855949952002787 2.54308490995491e-13 MirTarget -0.0534615705317411 0.0141933939023164 NA NA NA hsa-let-7e-5p XIAP 0.821771857232799 1.19334423679144e-10 -0.124283794566512 0.175947573716237 miRNAWalker2_validate -0.122305772139256 0.000264984462602976 NA NA NA hsa-miR-106b-5p XIAP 2.17788294729604 3.35797658884941e-37 -0.124283794566512 0.175947573716237 miRNATAP -0.0970915109236753 2.79550290081711e-05 NA NA NA hsa-miR-146b-5p XIAP 1.31285313891779 3.27846083137877e-10 -0.124283794566512 0.175947573716237 mirMAP;miRNATAP -0.0599279861497962 0.00317401113564784 NA NA NA hsa-miR-17-5p XIAP 2.26819952852251 1.17080117367962e-29 -0.124283794566512 0.175947573716237 miRNAWalker2_validate;TargetScan -0.0918426100247167 4.51254970007849e-06 NA NA NA hsa-miR-186-5p XIAP 1.01160002003511 1.0995153919986e-13 -0.124283794566512 0.175947573716237 MirTarget;miRNATAP -0.0678305296776992 0.0299848398734535 NA NA NA hsa-miR-188-5p XIAP 1.83180846049089 3.69593490679723e-16 -0.124283794566512 0.175947573716237 mirMAP -0.057357163874683 0.00205528394999878 NA NA NA hsa-miR-19a-3p XIAP 1.84830198357993 2.4710712042826e-20 -0.124283794566512 0.175947573716237 mirMAP -0.0741000807914024 0.000331090072996309 NA NA NA hsa-miR-19b-1-5p XIAP 0.959999569197417 4.46371760817159e-06 -0.124283794566512 0.175947573716237 MirTarget -0.0524733948831771 0.0106289969223536 NA NA NA hsa-miR-19b-3p XIAP 1.34004947278979 5.26920324973452e-16 -0.124283794566512 0.175947573716237 mirMAP -0.0846014782181944 0.000850900882580456 NA NA NA hsa-miR-20a-5p XIAP 1.51276418035651 8.71307033346922e-13 -0.124283794566512 0.175947573716237 miRNATAP -0.0834673822798687 2.53474531933611e-05 NA NA NA hsa-miR-2355-3p XIAP 0.559162737689355 0.0070739288416939 -0.124283794566512 0.175947573716237 MirTarget;miRNATAP -0.0661494778723931 0.00165814486990374 NA NA NA hsa-miR-23b-3p XIAP -0.940125237183254 5.29255710761003e-10 -0.124283794566512 0.175947573716237 MirTarget;miRNATAP -0.0729160601730344 0.00986949397252847 NA NA NA hsa-miR-25-3p XIAP 1.36338550911959 2.27429614057655e-21 -0.124283794566512 0.175947573716237 mirMAP -0.0718550805291721 0.0131714221492457 NA NA NA hsa-miR-27b-3p XIAP -0.936575637317446 2.43405225499419e-09 -0.124283794566512 0.175947573716237 miRNATAP -0.0569166980626343 0.0371114010247551 NA NA NA hsa-miR-32-3p XIAP 2.40467177052961 5.81388257063569e-26 -0.124283794566512 0.175947573716237 mirMAP -0.0528401497066358 0.00588860592389846 NA NA NA hsa-miR-32-5p XIAP 1.61585199704519 4.93530744182272e-20 -0.124283794566512 0.175947573716237 mirMAP -0.0717250520785319 0.00233650229010027 NA NA NA hsa-miR-335-3p XIAP 1.32116009044055 1.0694366259168e-09 -0.124283794566512 0.175947573716237 mirMAP -0.120458864546001 4.06996438722781e-10 NA NA NA hsa-miR-338-5p XIAP 0.585864914585632 0.0447092071232699 -0.124283794566512 0.175947573716237 MirTarget;mirMAP -0.052783653723376 0.000379679606638116 NA NA NA hsa-miR-340-5p XIAP 1.35294088371205 8.25205106713644e-16 -0.124283794566512 0.175947573716237 mirMAP;miRNATAP -0.0521379813122508 0.0374072330109185 NA NA NA hsa-miR-361-5p XIAP 0.505614361096266 0.000106749108296893 -0.124283794566512 0.175947573716237 miRanda -0.0772247183371171 0.0208244494533862 NA NA NA hsa-miR-421 XIAP 2.10188043858202 8.21949037851434e-21 -0.124283794566512 0.175947573716237 miRanda;miRNATAP -0.0816022572340652 8.8441217741144e-06 NA NA NA hsa-miR-92a-3p XIAP 1.69110879028255 8.04580501722806e-26 -0.124283794566512 0.175947573716237 mirMAP -0.0916447669105462 0.000309319270568192 NA NA NA hsa-miR-92b-3p XIAP 2.30712626248952 3.58511983194853e-19 -0.124283794566512 0.175947573716237 mirMAP -0.0527422064751955 0.00100469134209093 NA NA NA