miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-107 ACTG1 0.140046250553248 0.0943611632552367 -0.0915803450128578 0.185879739274575 miRanda;miRNATAP -0.160007560120434 0.000467774591021263 NA NA NA hsa-let-7i-5p AMOT 0.911372377723717 7.11483853341932e-31 -0.584287135074711 2.51779304217647e-07 MirTarget -0.40041911695927 3.61756748520355e-08 NA NA NA hsa-miR-103a-3p AMOT 0.779373475434461 7.37867196796994e-20 -0.584287135074711 2.51779304217647e-07 MirTarget -0.34438953978049 8.13523385153002e-07 NA NA NA hsa-miR-132-3p AMOT 0.291409674711894 0.000912684337101876 -0.584287135074711 2.51779304217647e-07 MirTarget -0.253722296399723 0.000452549309248428 NA NA NA hsa-miR-16-1-3p AMOT 1.51429140700091 3.17219833254498e-37 -0.584287135074711 2.51779304217647e-07 mirMAP -0.141618521732656 0.00347711319259354 NA NA NA hsa-miR-16-5p AMOT 0.934012514027655 4.85417898318515e-24 -0.584287135074711 2.51779304217647e-07 miRNAWalker2_validate -0.23547734996994 0.00023950895723651 NA NA NA hsa-miR-21-3p AMOT 1.78837590049697 1.41655409877312e-33 -0.584287135074711 2.51779304217647e-07 mirMAP -0.162083885395603 2.41259505859637e-05 NA NA NA hsa-miR-212-3p AMOT 0.140490094813501 0.298248972687012 -0.584287135074711 2.51779304217647e-07 MirTarget -0.129547007981259 0.00653306259975634 NA NA NA hsa-miR-221-3p AMOT 0.337895669520713 0.0136448974691037 -0.584287135074711 2.51779304217647e-07 miRNAWalker2_validate -0.243545279923006 9.61763492140733e-08 NA NA NA hsa-miR-29a-3p AMOT -0.431613225927952 4.10166815070288e-08 -0.584287135074711 2.51779304217647e-07 MirTarget;miRNATAP -0.214337017156318 0.00751892510430494 NA NA NA hsa-miR-29b-3p AMOT -0.228125979913806 0.0271621721891603 -0.584287135074711 2.51779304217647e-07 MirTarget;miRNATAP -0.205380834632144 0.000871011495916957 NA NA NA hsa-miR-330-5p AMOT 1.44960468659754 2.12131210588035e-45 -0.584287135074711 2.51779304217647e-07 miRanda -0.198365061104962 0.000224536663743998 NA NA NA hsa-miR-342-3p AMOT 1.4124432570595 1.07208971556131e-28 -0.584287135074711 2.51779304217647e-07 miRanda -0.190246992464426 2.92312062419476e-05 NA NA NA hsa-miR-576-5p AMOT 1.06681109513983 5.69294424466526e-24 -0.584287135074711 2.51779304217647e-07 mirMAP -0.18832046033623 0.000773594922874823 NA NA NA hsa-miR-590-3p AMOT 1.13702599385212 3.53435739887793e-22 -0.584287135074711 2.51779304217647e-07 mirMAP -0.294848331915999 3.22948646920278e-09 NA NA NA hsa-miR-106b-5p APC 1.07509411417907 2.11739194181878e-36 -0.15768599113557 0.0403437307908737 miRNAWalker2_validate;miRTarBase -0.249006085204911 1.29608123507827e-08 23087084 miR 106b downregulates adenomatous polyposis coli and promotes cell proliferation in human hepatocellular carcinoma; Moreover we demonstrated that miR-106b downregulates APC expression by directly targeting the 3'-untranslated region of APC messenger RNA; Taken together our results suggest that miR-106b plays an important role in promoting the proliferation of human hepatoma cells and presents a novel mechanism of micro RNA-mediated direct suppression of APC expression in cancer cells liver cancer hsa-miR-193a-3p APC 0.849206638484406 3.68101781083335e-14 -0.15768599113557 0.0403437307908737 miRanda -0.106642893279778 0.0034172724513806 NA NA NA hsa-miR-21-5p APC 2.51462371613332 3.30620591950316e-66 -0.15768599113557 0.0403437307908737 miRNAWalker2_validate -0.107167440411454 4.2657877359762e-06 23773491;24832083 The prognostic significance of APC gene mutation and miR 21 expression in advanced stage colorectal cancer; The aim of this study was to analyse the association of APC gene mutation and miR-21 expression with clinical outcome in CRC patients; APC gene mutation and expression of APC and miR-21 were analysed by direct DNA sequencing and real-time reverse transcription polymerase chain reaction; APC gene expression was low in CRC and negatively correlated with miR-21 expression and gene mutation; In Taiwan downregulation of the APC gene in CRC correlated with gene mutation and miR-21 upregulation; APC mutation and miR-21 expression could be used to predict the clinical outcome of CRC especially in patients with advanced disease;MicroRNA 21 promotes tumour malignancy via increased nuclear translocation of β catenin and predicts poor outcome in APC mutated but not in APC wild type colorectal cancer; However in our preliminary data the prognostic value of miR-21 levels was observed only in adenomatous polyposis coli APC-mutated tumours not in APC-wild-type tumours; We enrolled 165 colorectal tumour to determine APC mutation miR-21 levels and nuclear β-catenin expression by direct sequencing real-time PCR and immunohistochemistry staging; colorectal cancer;colorectal cancer hsa-miR-27a-3p APC 0.558934437526245 1.44256383086177e-12 -0.15768599113557 0.0403437307908737 miRNAWalker2_validate;miRTarBase;miRNATAP -0.169866262507951 0.00114991029977032 22018270 Finally the APC gene was identified as the direct and functional target of miR-27 gastric cancer hsa-miR-590-3p APC 1.13702599385212 3.53435739887793e-22 -0.15768599113557 0.0403437307908737 PITA;miRanda;mirMAP;miRNATAP -0.108828886407415 0.00128167370350013 NA NA NA hsa-miR-199a-5p APC2 -1.64658415208633 1.01615659358973e-23 1.13536383289961 1.45436846960249e-11 mirMAP -0.174038345118553 0.0013263478313172 NA NA NA hsa-miR-30b-3p APC2 -1.64703050862226 1.89878531036464e-31 1.13536383289961 1.45436846960249e-11 MirTarget -0.278737662587965 5.61321103594452e-06 NA NA NA hsa-miR-345-5p APC2 -0.953479075875024 8.95459389953487e-14 1.13536383289961 1.45436846960249e-11 mirMAP -0.189671029522005 0.00863222439683205 NA NA NA hsa-miR-500a-3p APC2 -1.41379327701944 2.73403824528455e-37 1.13536383289961 1.45436846960249e-11 mirMAP -0.42831663479774 1.57933994893993e-08 NA NA NA hsa-miR-505-5p APC2 -0.109332726329313 0.346400159841743 1.13536383289961 1.45436846960249e-11 mirMAP -0.23808917840165 0.00409542878410238 NA NA NA hsa-miR-664a-5p APC2 -0.618481839889218 7.01961389909184e-09 1.13536383289961 1.45436846960249e-11 mirMAP -0.278213810599959 0.00155606647548434 NA NA NA hsa-miR-217 AREG -1.32414431829977 4.20138196453017e-06 1.08083448160875 1.79410213062414e-06 miRanda -0.149583840613324 0.000552223055467858 NA NA NA hsa-miR-335-5p AREG -2.09515619961552 1.03765771499548e-25 1.08083448160875 1.79410213062414e-06 miRNAWalker2_validate -0.275659776397617 2.46001341247139e-06 NA NA NA hsa-miR-429 AREG -2.16569233119434 2.66862243626443e-37 1.08083448160875 1.79410213062414e-06 miRanda -0.265862560949342 5.65995820091643e-05 NA NA NA hsa-miR-103a-3p AXIN2 0.779373475434461 7.37867196796994e-20 -1.42112388340711 5.69079581588302e-24 miRNAWalker2_validate;MirTarget;miRNATAP -0.316230522107144 0.00064507661434146 NA NA NA hsa-miR-107 AXIN2 0.140046250553248 0.0943611632552367 -1.42112388340711 5.69079581588302e-24 miRTarBase;MirTarget;PITA;miRanda;miRNATAP -0.373826426799397 0.000198551477693208 26191213 miR 107 promotes hepatocellular carcinoma cell proliferation by targeting Axin2; At the molecular level our results suggested that expression of Axin2 was negatively regulated by miR-107; Our observations suggested that miR-107 could promote HCC cells proliferation via targeting Axin2 and might represent a potential therapeutic target for HCC liver cancer hsa-miR-144-3p AXIN2 1.4617706700291 9.18139413836375e-11 -1.42112388340711 5.69079581588302e-24 MirTarget -0.145875129803373 4.48569552427156e-05 NA NA NA hsa-miR-15a-5p AXIN2 1.42663930007845 1.36006952074963e-57 -1.42112388340711 5.69079581588302e-24 MirTarget;miRNATAP -0.582113800525649 1.46688876992611e-14 26252081 The combination of miR-15a and AXIN2 significantly improved the diagnostic accuracy thyroid cancer hsa-miR-15b-5p AXIN2 0.773001494057531 1.71784656078957e-16 -1.42112388340711 5.69079581588302e-24 miRTarBase;MirTarget;miRNATAP -0.342724694698479 5.4245165535984e-05 NA NA NA hsa-miR-16-2-3p AXIN2 1.3046118743965 4.17207934608428e-19 -1.42112388340711 5.69079581588302e-24 mirMAP -0.240582220065484 7.0940193187666e-06 NA NA NA hsa-miR-16-5p AXIN2 0.934012514027655 4.85417898318515e-24 -1.42112388340711 5.69079581588302e-24 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.443609556369372 1.01328202128578e-07 NA NA NA hsa-miR-590-3p AXIN2 1.13702599385212 3.53435739887793e-22 -1.42112388340711 5.69079581588302e-24 MirTarget;PITA;miRanda;miRNATAP -0.382937110546424 5.07807462140002e-09 NA NA NA hsa-miR-592 AXIN2 2.6404220268798 8.81369998128794e-32 -1.42112388340711 5.69079581588302e-24 MirTarget -0.187347712491187 1.65995337955582e-08 NA NA NA hsa-let-7a-2-3p BBC3 -0.705630646340993 0.000144853804998033 1.75566316130021 1.76416493109491e-40 MirTarget -0.1517830432058 0.000592618324382137 NA NA NA hsa-miR-125a-5p BBC3 -0.561874059994802 7.3931856356891e-13 1.75566316130021 1.76416493109491e-40 miRNATAP -0.696473009379469 2.83248423959075e-12 NA NA NA hsa-miR-125b-5p BBC3 -0.825456421494266 2.13029877878434e-15 1.75566316130021 1.76416493109491e-40 miRNAWalker2_validate;miRTarBase -0.347060151160859 4.29378421184582e-06 25184537 Thus far two of these target genes BBC3 and NEU1 that are tumor suppressor genes but not yet studied in PDAC appear to be functional targets of miR-125b since knockdown of miR125b caused their up regulation pancreatic cancer hsa-miR-135a-5p BBC3 -2.13422485001223 6.29449029671498e-14 1.75566316130021 1.76416493109491e-40 mirMAP -0.180480973886956 8.95333652480316e-11 NA NA NA hsa-miR-139-5p BBC3 -0.704802495091118 2.36904108453776e-06 1.75566316130021 1.76416493109491e-40 miRNATAP -0.349406785626358 4.67596766708615e-11 NA NA NA hsa-miR-149-5p BBC3 -1.95790336710741 8.46371715052367e-27 1.75566316130021 1.76416493109491e-40 miRNATAP -0.208984707469125 3.65311497564959e-07 NA NA NA hsa-miR-27b-3p BBC3 -0.699527231242518 1.07356023759234e-15 1.75566316130021 1.76416493109491e-40 miRNATAP -0.361031786691849 6.80182383598724e-05 NA NA NA hsa-miR-324-3p BBC3 -0.197662887871899 0.0298845059559819 1.75566316130021 1.76416493109491e-40 PITA -0.386199658186468 2.13640366451208e-05 NA NA NA hsa-miR-345-5p BBC3 -0.953479075875024 8.95459389953487e-14 1.75566316130021 1.76416493109491e-40 miRNATAP -0.280788216556717 5.16976770846981e-06 NA NA NA hsa-miR-429 BBC3 -2.16569233119434 2.66862243626443e-37 1.75566316130021 1.76416493109491e-40 miRNATAP -0.271585955257017 1.21843200977875e-10 NA NA NA hsa-miR-532-3p BBC3 -1.759223962964 7.9077916669414e-40 1.75566316130021 1.76416493109491e-40 PITA;miRNATAP -0.506248513800269 4.84937056145532e-23 NA NA NA hsa-miR-29a-3p BIRC2 -0.431613225927952 4.10166815070288e-08 0.0936851144208237 0.0807862381939828 MirTarget -0.170009571948633 3.51674867601628e-06 NA NA NA hsa-miR-10a-5p BIRC5 -1.17164272592931 4.86621098042279e-24 3.07119637658488 1.55919141868224e-42 miRNAWalker2_validate -1.08062124207166 2.42539294896864e-24 NA NA NA hsa-miR-149-5p BIRC5 -1.95790336710741 8.46371715052367e-27 3.07119637658488 1.55919141868224e-42 miRNAWalker2_validate -0.265827420121681 0.000188746694918092 NA NA NA hsa-miR-203a-3p BIRC5 -2.25533513338731 1.77332845294014e-21 3.07119637658488 1.55919141868224e-42 miRTarBase -0.354007380867186 8.44810917510953e-11 22713668;27714672 Luciferase assays were also performed to validate BIRC5 and LASP1 as miR-203 targets; Both miR-203 and BIRC5 siRNA signicantly inhibited cell proliferation in TNBC cells; Moreover up-regulated of BIRC5 and LASP1 was able to abrogate the effects induced by transfection with the miR-203 precursor;miR 203 is a predictive biomarker for colorectal cancer and its expression is associated with BIRC5; The purpose of this study was to explore the role of miR-203 in colorectal cancer CRC and evaluate the correlation between miR-203 and BIRC5; Finally miR-203 expression was negatively associated with that of BIRC5 r = -0.8150 P < 0.05 ; breast cancer;colorectal cancer hsa-miR-30c-5p BIRC5 -1.08783070774238 2.02505402525786e-24 3.07119637658488 1.55919141868224e-42 miRNAWalker2_validate -1.06112151801303 1.30471168211512e-19 NA NA NA hsa-miR-335-5p BIRC5 -2.09515619961552 1.03765771499548e-25 3.07119637658488 1.55919141868224e-42 miRNAWalker2_validate;MirTarget -0.257806377043058 8.89253493483187e-05 23232114 Genetic variation in a miR 335 binding site in BIRC5 alters susceptibility to lung cancer in Chinese Han populations; In support of the postulation that the 3' UTR SNP may directly affect miRNA-binding site reporter gene assays indicated BIRC5 was a direct target of miR-335 and the rs2239680 T>C change resulted in altered regulation of BIRC5 expression; Our findings defined a 3' UTR SNP in human BIRC5 oncogene that may increase individual susceptibility to lung cancer probably by attenuating the interaction between miR-335 and BIRC5 lung cancer hsa-miR-335-3p BMP2 -1.36498175550207 6.84287752180534e-13 0.831511383264696 6.76607430560287e-10 mirMAP -0.187829223995717 9.19547131860688e-07 NA NA NA hsa-miR-335-5p BMP2 -2.09515619961552 1.03765771499548e-25 0.831511383264696 6.76607430560287e-10 miRNAWalker2_validate -0.191663479184032 4.34381039458658e-08 NA NA NA hsa-miR-429 BMP2 -2.16569233119434 2.66862243626443e-37 0.831511383264696 6.76607430560287e-10 miRNATAP -0.119687627342262 0.00273815212178293 NA NA NA hsa-miR-590-3p BMP4 1.13702599385212 3.53435739887793e-22 -0.429324992826978 0.0117794300544142 miRanda -0.240598867382324 0.00139004780946765 NA NA NA hsa-miR-340-5p BMP5 1.14479851941741 2.91936881701444e-15 -1.92654666318502 3.41371522631686e-06 mirMAP -0.546241159381967 0.000348814314994503 NA NA NA hsa-miR-576-5p BMP5 1.06681109513983 5.69294424466526e-24 -1.92654666318502 3.41371522631686e-06 mirMAP -1.11499777226712 3.19175201062592e-08 NA NA NA hsa-miR-590-3p BMP5 1.13702599385212 3.53435739887793e-22 -1.92654666318502 3.41371522631686e-06 mirMAP -0.502694213899833 0.00683045980930541 NA NA NA hsa-miR-130b-3p BMP6 1.12788913578446 2.939369462276e-16 -1.74183042251816 1.50748934184471e-24 MirTarget -0.556045113223564 1.17484148725638e-16 NA NA NA hsa-miR-301a-3p BMP6 0.259400847075798 0.0216890736701418 -1.74183042251816 1.50748934184471e-24 MirTarget -0.249859979588016 0.00547601725085616 NA NA NA hsa-miR-454-3p BMP6 0.68285296887698 1.17407812677787e-08 -1.74183042251816 1.50748934184471e-24 MirTarget -0.463063921783562 1.34895056734753e-08 NA NA NA hsa-miR-590-3p BMP6 1.13702599385212 3.53435739887793e-22 -1.74183042251816 1.50748934184471e-24 mirMAP -0.661288437419974 1.0246175481456e-17 NA NA NA hsa-miR-590-5p BMP6 0.709763558412506 1.11883921359361e-11 -1.74183042251816 1.50748934184471e-24 miRanda -0.571143840759623 5.82000916819767e-10 NA NA NA hsa-let-7b-5p BMP7 0.770868211539597 6.63408323707647e-21 -6.92608810767782 2.35176226012524e-57 miRNAWalker2_validate -2.83712633140975 1.19691469233079e-19 NA NA NA hsa-miR-106b-5p BMP7 1.07509411417907 2.11739194181878e-36 -6.92608810767782 2.35176226012524e-57 mirMAP -2.53716682031083 8.81091286294983e-19 NA NA NA hsa-miR-130b-5p BMP7 0.92990617673277 3.75880436852717e-12 -6.92608810767782 2.35176226012524e-57 mirMAP -0.880046844779973 1.91343744289084e-05 NA NA NA hsa-miR-17-5p BMP7 0.494260110870015 3.8348005261e-09 -6.92608810767782 2.35176226012524e-57 mirMAP -1.80263099286619 5.521268659583e-08 NA NA NA hsa-miR-20a-5p BMP7 0.702602695798242 4.06372887613329e-13 -6.92608810767782 2.35176226012524e-57 mirMAP -1.99017710088704 7.96097338913785e-13 NA NA NA hsa-miR-338-3p BMP7 0.906250377628867 2.76970900371139e-15 -6.92608810767782 2.35176226012524e-57 miRanda -1.77837947413814 1.33949809543213e-14 NA NA NA hsa-miR-342-3p BMP7 1.4124432570595 1.07208971556131e-28 -6.92608810767782 2.35176226012524e-57 miRNAWalker2_validate;miRTarBase;miRanda -1.54558235099195 7.70208749640374e-15 NA NA NA hsa-miR-34a-5p BMP7 1.07544567720768 1.81510842038009e-20 -6.92608810767782 2.35176226012524e-57 miRNAWalker2_validate -1.18766663146368 2.41157668366611e-07 NA NA NA hsa-miR-450b-5p BMP7 0.404819502355575 0.00357671373841274 -6.92608810767782 2.35176226012524e-57 mirMAP -0.630926416830189 0.00216356233441174 NA NA NA hsa-miR-455-5p BMP7 0.773674551205946 2.12957541541474e-09 -6.92608810767782 2.35176226012524e-57 miRanda -1.25609385334881 3.50104991522145e-09 NA NA NA hsa-miR-542-3p BMP7 0.431147917094433 0.000254981247606435 -6.92608810767782 2.35176226012524e-57 miRanda;miRNATAP -0.763476888217506 0.00160296518085342 NA NA NA hsa-miR-93-5p BMP7 1.37365940377595 2.37567548683245e-46 -6.92608810767782 2.35176226012524e-57 mirMAP -2.84231819971105 5.45158520475942e-34 NA NA NA hsa-miR-194-3p BMP8A -0.0573594560647068 0.802137112420482 1.02954764181145 3.23839941548381e-11 MirTarget -0.128663465263968 0.000973218684259517 NA NA NA hsa-miR-30a-3p BMP8A -0.955360819934585 1.97009535429185e-20 1.02954764181145 3.23839941548381e-11 MirTarget -0.515711290326419 5.8053356292635e-11 NA NA NA hsa-miR-30b-3p BMP8A -1.64703050862226 1.89878531036464e-31 1.02954764181145 3.23839941548381e-11 MirTarget -0.385546200865383 3.39982062468849e-12 NA NA NA hsa-miR-30d-3p BMP8A -0.249777194282131 0.00235356711813496 1.02954764181145 3.23839941548381e-11 MirTarget -0.459203788337865 1.885887679145e-05 NA NA NA hsa-miR-30e-3p BMP8A -0.205602546270795 0.00132666419729688 1.02954764181145 3.23839941548381e-11 MirTarget -0.731322193185212 1.11579520142953e-07 NA NA NA hsa-miR-20b-5p BMP8B -1.30218163823367 6.87172815978149e-17 0.637005026988659 0.000465199283842601 MirTarget -0.171656599253089 0.00548853728451988 NA NA NA hsa-miR-33a-5p BMP8B -1.59840463890997 1.13487952314403e-18 0.637005026988659 0.000465199283842601 mirMAP -0.264863577160741 4.10848048616839e-07 NA NA NA hsa-miR-362-5p BMP8B -2.72767654824605 1.34821749679113e-49 0.637005026988659 0.000465199283842601 mirMAP -0.2895804455397 2.5570066718275e-10 NA NA NA hsa-miR-363-3p BMP8B -1.93551166555337 4.45368477487614e-32 0.637005026988659 0.000465199283842601 mirMAP -0.212191403822407 0.000132528089251384 NA NA NA hsa-miR-140-5p BMPR1A 0.504309496243674 3.09884038729031e-11 -0.597566615344153 1.42772967642368e-21 miRanda -0.168308968990087 0.000379502075023961 NA NA NA hsa-miR-142-5p BMPR1A 1.88417391525707 1.2096808039882e-27 -0.597566615344153 1.42772967642368e-21 MirTarget -0.132776007105062 2.09806010889144e-12 NA NA NA hsa-miR-340-5p BMPR1A 1.14479851941741 2.91936881701444e-15 -0.597566615344153 1.42772967642368e-21 MirTarget -0.10048334750192 3.01886474003622e-05 NA NA NA hsa-miR-584-5p BMPR1A 2.09455345496517 1.01738783798409e-51 -0.597566615344153 1.42772967642368e-21 MirTarget -0.150889617907284 5.78827308426318e-12 NA NA NA hsa-miR-589-5p BMPR1A 0.696241532021631 5.26958362886071e-16 -0.597566615344153 1.42772967642368e-21 MirTarget -0.245160547688166 1.1498781828623e-09 NA NA NA hsa-miR-942-5p BMPR1A 0.978672610596303 3.12802933163696e-12 -0.597566615344153 1.42772967642368e-21 MirTarget -0.125542947142203 5.35570354370088e-07 NA NA NA hsa-miR-101-3p BMPR1B 0.683973909682285 2.88573524246948e-15 -5.93705342012142 1.80069195148303e-49 miRNATAP -2.07183572640389 9.87326298288974e-14 NA NA NA hsa-miR-130b-3p BMPR1B 1.12788913578446 2.939369462276e-16 -5.93705342012142 1.80069195148303e-49 miRNATAP -0.89057706084496 5.04979813562585e-07 NA NA NA hsa-miR-140-3p BMPR1B 0.989350547007025 6.14964028267239e-25 -5.93705342012142 1.80069195148303e-49 MirTarget -2.16128185437479 1.0295533558312e-19 NA NA NA hsa-miR-142-5p BMPR1B 1.88417391525707 1.2096808039882e-27 -5.93705342012142 1.80069195148303e-49 mirMAP -1.09048423713365 9.77646692765523e-17 NA NA NA hsa-miR-144-3p BMPR1B 1.4617706700291 9.18139413836375e-11 -5.93705342012142 1.80069195148303e-49 MirTarget;miRNATAP -0.440033388349529 7.24837347146203e-05 NA NA NA hsa-miR-146b-5p BMPR1B 1.40714170253819 2.9559871816487e-12 -5.93705342012142 1.80069195148303e-49 miRanda -0.725753236534014 2.27681429411658e-09 NA NA NA hsa-miR-150-5p BMPR1B 1.00371863159681 1.09871676395528e-09 -5.93705342012142 1.80069195148303e-49 MirTarget -0.64554594868248 2.20632065533901e-05 NA NA NA hsa-miR-16-2-3p BMPR1B 1.3046118743965 4.17207934608428e-19 -5.93705342012142 1.80069195148303e-49 mirMAP -0.897431333266518 5.25001555664885e-08 NA NA NA hsa-miR-23a-3p BMPR1B 0.761438723382355 4.09310879199257e-27 -5.93705342012142 1.80069195148303e-49 mirMAP -2.28243788714606 6.22095112536466e-12 NA NA NA hsa-miR-301a-3p BMPR1B 0.259400847075798 0.0216890736701418 -5.93705342012142 1.80069195148303e-49 miRNATAP -0.608202482158667 0.00820272144899561 NA NA NA hsa-miR-330-3p BMPR1B 0.912906550436308 3.35037014057665e-13 -5.93705342012142 1.80069195148303e-49 mirMAP -1.32144639822333 2.63449562152609e-11 NA NA NA hsa-miR-331-3p BMPR1B 0.431607034018882 6.83022920590941e-05 -5.93705342012142 1.80069195148303e-49 miRNATAP -0.696688391064995 0.00338744054570495 NA NA NA hsa-miR-374a-5p BMPR1B 0.543061152108237 2.19403097299769e-14 -5.93705342012142 1.80069195148303e-49 MirTarget -2.3823899597912 4.47204123414504e-12 NA NA NA hsa-miR-421 BMPR1B 0.313155739887734 0.020433534776003 -5.93705342012142 1.80069195148303e-49 miRanda -0.718102325061687 0.000273769650641837 NA NA NA hsa-miR-576-5p BMPR1B 1.06681109513983 5.69294424466526e-24 -5.93705342012142 1.80069195148303e-49 mirMAP -1.54058909889206 3.89101279273479e-12 NA NA NA hsa-miR-590-3p BMPR1B 1.13702599385212 3.53435739887793e-22 -5.93705342012142 1.80069195148303e-49 miRanda;mirMAP -1.27013994492895 3.43061689687736e-10 NA NA NA hsa-miR-629-3p BMPR1B 1.09330044556689 2.9533160808356e-14 -5.93705342012142 1.80069195148303e-49 MirTarget -0.793870761715422 5.33553831920598e-06 NA NA NA hsa-miR-7-1-3p BMPR1B 0.544601828025304 5.33830451326047e-07 -5.93705342012142 1.80069195148303e-49 MirTarget -1.15661426435319 6.65490342478668e-07 NA NA NA hsa-miR-106b-5p BMPR2 1.07509411417907 2.11739194181878e-36 -0.224905337790899 0.00657704344968733 MirTarget;miRNATAP -0.268435817635523 1.3485195450772e-08 NA NA NA hsa-miR-128-3p BMPR2 0.475045893035043 2.6255647468e-06 -0.224905337790899 0.00657704344968733 miRNAWalker2_validate -0.140561111346175 0.00167918120621767 NA NA NA hsa-miR-130b-3p BMPR2 1.12788913578446 2.939369462276e-16 -0.224905337790899 0.00657704344968733 MirTarget;miRNATAP -0.128551430453156 4.38739325133517e-05 NA NA NA hsa-miR-148a-5p BMPR2 0.415500302855613 0.000691460831436767 -0.224905337790899 0.00657704344968733 mirMAP -0.180704107286542 8.61585394548294e-07 NA NA NA hsa-miR-185-5p BMPR2 1.05056378692621 1.31174187880682e-22 -0.224905337790899 0.00657704344968733 MirTarget -0.119503102476259 0.00271168193608352 NA NA NA hsa-miR-30b-5p BMPR2 -1.18330589477119 6.8341618466966e-27 -0.224905337790899 0.00657704344968733 mirMAP -0.12526291924665 0.00104398594625501 NA NA NA hsa-miR-32-5p BMPR2 0.407826130035097 7.26884631998646e-06 -0.224905337790899 0.00657704344968733 miRNATAP -0.146481250878684 0.00338950286662681 NA NA NA hsa-miR-362-3p BMPR2 -0.753214251798232 3.0025661608035e-07 -0.224905337790899 0.00657704344968733 MirTarget;PITA;miRanda;miRNATAP -0.100155428261034 0.00147002328660512 NA NA NA hsa-miR-590-3p BMPR2 1.13702599385212 3.53435739887793e-22 -0.224905337790899 0.00657704344968733 MirTarget;miRanda;mirMAP;miRNATAP -0.139898702095111 0.000118846389647125 NA NA NA hsa-miR-590-5p BMPR2 0.709763558412506 1.11883921359361e-11 -0.224905337790899 0.00657704344968733 MirTarget;PITA;miRNATAP -0.130713790403962 0.0020914132017247 NA NA NA hsa-miR-625-3p BMPR2 1.09679549288964 4.60800634006165e-20 -0.224905337790899 0.00657704344968733 mirMAP -0.119699686452322 0.000878997223184353 NA NA NA hsa-miR-651-5p BMPR2 0.535144061895781 2.49922577209869e-05 -0.224905337790899 0.00657704344968733 MirTarget -0.183795464789673 9.09963361894442e-07 NA NA NA hsa-miR-103a-3p BTRC 0.779373475434461 7.37867196796994e-20 -0.545867409195286 1.13119496175858e-27 MirTarget;miRNATAP -0.156858597729153 1.83104480165876e-06 NA NA NA hsa-miR-130b-3p BTRC 1.12788913578446 2.939369462276e-16 -0.545867409195286 1.13119496175858e-27 mirMAP -0.144280350974826 6.13672882734612e-13 NA NA NA hsa-miR-130b-5p BTRC 0.92990617673277 3.75880436852717e-12 -0.545867409195286 1.13119496175858e-27 mirMAP -0.105538020598352 7.69972784747403e-07 NA NA NA hsa-miR-132-3p BTRC 0.291409674711894 0.000912684337101876 -0.545867409195286 1.13119496175858e-27 MirTarget -0.129126336685942 0.0001435195224679 NA NA NA hsa-miR-15a-5p BTRC 1.42663930007845 1.36006952074963e-57 -0.545867409195286 1.13119496175858e-27 miRNAWalker2_validate;MirTarget;miRNATAP -0.230730881494424 6.85365099919491e-18 NA NA NA hsa-miR-15b-5p BTRC 0.773001494057531 1.71784656078957e-16 -0.545867409195286 1.13119496175858e-27 MirTarget;miRNATAP -0.169319296214664 1.6922104014835e-08 NA NA NA hsa-miR-16-1-3p BTRC 1.51429140700091 3.17219833254498e-37 -0.545867409195286 1.13119496175858e-27 mirMAP -0.156445074463053 1.38612815677702e-12 NA NA NA hsa-miR-16-5p BTRC 0.934012514027655 4.85417898318515e-24 -0.545867409195286 1.13119496175858e-27 miRNAWalker2_validate;MirTarget;miRNATAP -0.171318107223812 7.9595536385704e-09 NA NA NA hsa-miR-185-5p BTRC 1.05056378692621 1.31174187880682e-22 -0.545867409195286 1.13119496175858e-27 mirMAP -0.109116377207476 2.52792357758926e-05 NA NA NA hsa-miR-186-5p BTRC 0.507217561043443 9.04455748270995e-10 -0.545867409195286 1.13119496175858e-27 mirMAP -0.10428635905381 0.00333143162251156 NA NA NA hsa-miR-193a-3p BTRC 0.849206638484406 3.68101781083335e-14 -0.545867409195286 1.13119496175858e-27 MirTarget;miRanda -0.193598648122405 4.78184966244523e-15 NA NA NA hsa-miR-224-5p BTRC 2.84654230414912 3.0480927226395e-47 -0.545867409195286 1.13119496175858e-27 MirTarget -0.100839462591653 7.35998388148681e-16 NA NA NA hsa-miR-28-5p BTRC 0.461962042257226 3.32424690573327e-11 -0.545867409195286 1.13119496175858e-27 miRanda -0.205658394015241 8.44931757973945e-07 NA NA NA hsa-miR-330-5p BTRC 1.44960468659754 2.12131210588035e-45 -0.545867409195286 1.13119496175858e-27 miRNATAP -0.194106328662025 1.53951860798049e-15 NA NA NA hsa-miR-342-3p BTRC 1.4124432570595 1.07208971556131e-28 -0.545867409195286 1.13119496175858e-27 mirMAP -0.13409305784049 1.82204492764768e-10 NA NA NA hsa-miR-361-3p BTRC 1.08992546227594 1.13197240706704e-36 -0.545867409195286 1.13119496175858e-27 MirTarget;PITA;miRNATAP -0.239205646830534 1.15277659748048e-15 NA NA NA hsa-miR-576-5p BTRC 1.06681109513983 5.69294424466526e-24 -0.545867409195286 1.13119496175858e-27 mirMAP -0.12041394454881 4.10050287105916e-06 NA NA NA hsa-miR-590-3p BTRC 1.13702599385212 3.53435739887793e-22 -0.545867409195286 1.13119496175858e-27 mirMAP -0.157591361491916 1.16894853403125e-11 NA NA NA hsa-miR-629-5p BTRC 1.73389921851483 5.39614356468007e-48 -0.545867409195286 1.13119496175858e-27 mirMAP -0.168107551118532 4.65511934120712e-16 NA NA NA hsa-let-7e-5p CCND1 -0.727009689927955 1.30690859412163e-11 2.13480598480786 2.71111034411853e-47 miRTarBase;miRNATAP -0.309874613270473 0.000283950841354646 NA NA NA hsa-let-7g-5p CCND1 -0.739744008507763 1.07979566264383e-14 2.13480598480786 2.71111034411853e-47 miRNATAP -0.622969784922631 1.85126618527679e-11 NA NA NA hsa-miR-106a-5p CCND1 -0.830908656792615 2.67547872901508e-10 2.13480598480786 2.71111034411853e-47 MirTarget;miRNATAP -0.425464553504269 5.26102842088565e-10 NA NA NA hsa-miR-135a-5p CCND1 -2.13422485001223 6.29449029671498e-14 2.13480598480786 2.71111034411853e-47 mirMAP -0.135832732621826 2.9303290026017e-05 NA NA NA hsa-miR-183-5p CCND1 -1.21596931064487 1.31473205758898e-08 2.13480598480786 2.71111034411853e-47 miRNAWalker2_validate -0.374903452579708 3.93459169450664e-20 NA NA NA hsa-miR-193b-3p CCND1 -0.273325765316079 0.104328826585392 2.13480598480786 2.71111034411853e-47 miRNAWalker2_validate;miRTarBase;MirTarget -0.242980057535361 1.3298535415108e-05 27071318;20655737;20304954;21893020;26129688 MicroRNA 193b inhibits the proliferation migration and invasion of gastric cancer cells via targeting cyclin D1; Further mechanism study indicated that CCND1 was a direct target of miR-193b in GC;CCND1 and ETS1 were revealed to be regulated by miR-193b directly;MicroRNA 193b represses cell proliferation and regulates cyclin D1 in melanoma; Overexpression of miR-193b in Malme-3M cells down-regulated CCND1 mRNA and protein by > or = 50%; A luciferase reporter assay confirmed that miR-193b directly regulates CCND1 by binding to the 3'untranslated region of CCND1 mRNA; These studies indicate that miR-193b represses cell proliferation and regulates CCND1 expression and suggest that dysregulation of miR-193b may play an important role in melanoma development;In a previous study we reported that miR-193b represses cell proliferation and regulates cyclin D1 in melanoma cells suggesting that miR-193b could act as a tumor suppressor;Epigenetically altered miR 193b targets cyclin D1 in prostate cancer; It has been suggested that miR-193b targets cyclin D1 in several malignancies; Here our aim was to determine if miR-193b targets cyclin D1 in prostate cancer; Furthermore the PC cell lines 22Rv1 and VCaP which express low levels of miR-193b and high levels of CCND1 showed significant growth retardation when treated with a CDK4/6 inhibitor; In contrast the inhibitor had no effect on the growth of PC-3 and DU145 cells with high miR-193b and low CCND1 expression; Taken together our data demonstrate that miR-193b targets cyclin D1 in prostate cancer ;;;; gastric cancer;liver cancer;melanoma;melanoma;prostate cancer hsa-miR-20b-5p CCND1 -1.30218163823367 6.87172815978149e-17 2.13480598480786 2.71111034411853e-47 MirTarget;miRNATAP -0.398854407061578 1.06454795591623e-12 NA NA NA hsa-miR-214-5p CCND1 -1.44418790803397 1.50873538772684e-16 2.13480598480786 2.71111034411853e-47 MirTarget -0.347168835410485 4.02103564566879e-12 NA NA NA hsa-miR-29a-3p CCND1 -0.431613225927952 4.10166815070288e-08 2.13480598480786 2.71111034411853e-47 mirMAP -0.939711765610188 1.68520368520268e-16 NA NA NA hsa-miR-29b-3p CCND1 -0.228125979913806 0.0271621721891603 2.13480598480786 2.71111034411853e-47 mirMAP -0.387608162335363 2.20893060555751e-05 NA NA NA hsa-miR-495-3p CCND1 -0.742293735164333 7.11373308013543e-05 2.13480598480786 2.71111034411853e-47 MirTarget -0.181526805649212 0.000432098784713278 NA NA NA hsa-miR-9-5p CCND1 -2.23538606210968 1.28143998950751e-12 2.13480598480786 2.71111034411853e-47 miRNAWalker2_validate -0.163701601563252 7.92305196930194e-09 NA NA NA hsa-let-7e-5p CCND2 -0.727009689927955 1.30690859412163e-11 1.12254248674744 2.60370825886318e-19 miRNATAP -0.233612834039481 0.000392482925172286 NA NA NA hsa-let-7g-5p CCND2 -0.739744008507763 1.07979566264383e-14 1.12254248674744 2.60370825886318e-19 miRNATAP -0.192686043584521 0.0089075831083671 NA NA NA hsa-miR-106a-5p CCND2 -0.830908656792615 2.67547872901508e-10 1.12254248674744 2.60370825886318e-19 miRNATAP -0.225423059951479 2.69299129795332e-05 NA NA NA hsa-miR-10a-3p CCND2 -1.40380922426511 3.42207767326254e-23 1.12254248674744 2.60370825886318e-19 mirMAP -0.262198638789585 6.25176630952157e-08 NA NA NA hsa-miR-10b-3p CCND2 -0.8205021989966 7.84331443044781e-21 1.12254248674744 2.60370825886318e-19 mirMAP -0.448238682535571 6.77944940531982e-09 NA NA NA hsa-miR-135a-5p CCND2 -2.13422485001223 6.29449029671498e-14 1.12254248674744 2.60370825886318e-19 miRNATAP -0.131225655723756 1.33192381495194e-07 NA NA NA hsa-miR-141-3p CCND2 -5.87110686537457 1.20877726722907e-85 1.12254248674744 2.60370825886318e-19 MirTarget;TargetScan -0.139228651988037 1.29114997683213e-14 NA NA NA hsa-miR-188-5p CCND2 -1.74586655806628 1.50431624674552e-28 1.12254248674744 2.60370825886318e-19 PITA;mirMAP -0.254549789518694 2.9475657150123e-09 NA NA NA hsa-miR-200a-3p CCND2 -1.43409013664263 2.00188483717828e-20 1.12254248674744 2.60370825886318e-19 MirTarget -0.212833658265287 1.19682362163716e-06 NA NA NA hsa-miR-20b-5p CCND2 -1.30218163823367 6.87172815978149e-17 1.12254248674744 2.60370825886318e-19 miRNATAP -0.259528470369076 2.90568654364943e-09 NA NA NA hsa-miR-26a-1-3p CCND2 -1.56107117111696 6.75439319582901e-15 1.12254248674744 2.60370825886318e-19 mirMAP -0.123054440828334 0.000561186412955267 NA NA NA hsa-miR-29a-3p CCND2 -0.431613225927952 4.10166815070288e-08 1.12254248674744 2.60370825886318e-19 MirTarget;miRNATAP -0.257180845680541 0.00521051024582081 22330340;24130168 In addition to CCND2 miR-29 also targets E2F7 another cell cycle regulator;We further demonstrated that miR-29 family acted as tumor suppressors through targeting CCND2 and matrix metalloproteinase-2 genes in GC ; sarcoma;gastric cancer hsa-miR-29a-5p CCND2 -0.519003718107105 1.03351148282116e-06 1.12254248674744 2.60370825886318e-19 mirMAP -0.175805947483669 0.00980240816278221 22330340;24130168 In addition to CCND2 miR-29 also targets E2F7 another cell cycle regulator;We further demonstrated that miR-29 family acted as tumor suppressors through targeting CCND2 and matrix metalloproteinase-2 genes in GC ; sarcoma;gastric cancer hsa-miR-29c-3p CCND2 -0.238671318446745 0.0141475322347596 1.12254248674744 2.60370825886318e-19 MirTarget;miRNATAP -0.244609702834514 0.0011551466386057 NA NA NA hsa-miR-3065-3p CCND2 -1.64500070417457 9.57561660036697e-16 1.12254248674744 2.60370825886318e-19 MirTarget;miRNATAP -0.15735746874687 2.91648572740269e-06 NA NA NA hsa-miR-30a-3p CCND2 -0.955360819934585 1.97009535429185e-20 1.12254248674744 2.60370825886318e-19 mirMAP -0.322061265215125 1.10079970812633e-06 NA NA NA hsa-miR-30d-3p CCND2 -0.249777194282131 0.00235356711813496 1.12254248674744 2.60370825886318e-19 mirMAP -0.528583706650002 1.57965043070812e-09 NA NA NA hsa-miR-335-5p CCND2 -2.09515619961552 1.03765771499548e-25 1.12254248674744 2.60370825886318e-19 miRNAWalker2_validate -0.125391196936535 0.000218373131234068 NA NA NA hsa-miR-378a-3p CCND2 0.287244802401236 0.0501155019984562 1.12254248674744 2.60370825886318e-19 miRNAWalker2_validate -0.155216456838451 0.00181246322617494 NA NA NA hsa-miR-429 CCND2 -2.16569233119434 2.66862243626443e-37 1.12254248674744 2.60370825886318e-19 miRNATAP -0.226547302813025 1.44251591184469e-09 NA NA NA hsa-miR-500a-5p CCND2 -1.28374735824553 1.95870374809798e-20 1.12254248674744 2.60370825886318e-19 mirMAP -0.227276642384328 3.82424468920894e-06 NA NA NA hsa-miR-501-5p CCND2 -1.1103073934745 1.81589804886553e-16 1.12254248674744 2.60370825886318e-19 PITA;mirMAP;miRNATAP -0.210338351972789 4.15719063926169e-05 NA NA NA hsa-miR-577 CCND2 -1.48881999472397 7.03080165111147e-10 1.12254248674744 2.60370825886318e-19 PITA;mirMAP -0.106625188470732 0.000293795265070961 NA NA NA hsa-miR-660-5p CCND2 -1.20833564582661 8.48975910642834e-23 1.12254248674744 2.60370825886318e-19 mirMAP -0.376740011929223 2.58290869632093e-12 NA NA NA hsa-miR-362-3p CCND3 -0.753214251798232 3.0025661608035e-07 0.51821271483815 4.41964906922001e-09 miRanda -0.139754455099983 4.25864164139051e-05 NA NA NA hsa-miR-501-5p CCND3 -1.1103073934745 1.81589804886553e-16 0.51821271483815 4.41964906922001e-09 PITA -0.131433527243481 0.000178229069185252 NA NA NA hsa-miR-146b-5p CDH1 1.40714170253819 2.9559871816487e-12 -1.86435402516367 3.67522478130053e-23 miRanda -0.282170142699047 7.65179960038226e-08 NA NA NA hsa-miR-185-5p CDH1 1.05056378692621 1.31174187880682e-22 -1.86435402516367 3.67522478130053e-23 MirTarget -0.640284232400987 1.23928770193842e-11 27212161;24025511 We also found that ectopic expression of miR-185 reversed EMT via the up-regulation of E-cadherin and down-regulation of vimentin in epithelial and mesenchymal HCC cells;After transfection of miR-185 inhibitor into KYSE30 the expression of E-cadherin a downstream protein of Six1 was observed under confocal microscope; After transfection of miR-185 inhibitorthe expression level of E-cadherin decreased ; liver cancer;esophageal cancer hsa-miR-186-5p CDH1 0.507217561043443 9.04455748270995e-10 -1.86435402516367 3.67522478130053e-23 mirMAP -0.826028473815464 1.61662922838972e-10 NA NA NA hsa-miR-22-3p CDH1 0.198460552200729 0.00761005672059428 -1.86435402516367 3.67522478130053e-23 MirTarget -0.551098179306345 0.000261166384335573 NA NA NA hsa-miR-23a-3p CDH1 0.761438723382355 4.09310879199257e-27 -1.86435402516367 3.67522478130053e-23 MirTarget -0.800334947540073 3.115073852808e-08 22752005;26110567 MiR 23a regulates TGF β induced epithelial mesenchymal transition by targeting E cadherin in lung cancer cells; Knockdown of miR-23a partially restored E-cadherin expression under conditions of TGF-β1 stimulation; In contrast overexpression of miR-23a could suppress E-cadherin expression and stimulate EMT; These findings suggest that miR-23a regulates TGF-β-induced EMT by targeting E-cadherin in lung cancer cells and may be useful as a new therapeutic target in NSCLC;Ectopic miR-23a-3p suppressed E-cadherin 3' untranslated region reporter activity and E-cadherin expression and relieved the motility suppression caused by osthole treatment ;motility lung cancer;prostate cancer hsa-miR-25-3p CDH1 1.12016166564779 3.79069348635778e-48 -1.86435402516367 3.67522478130053e-23 miRNAWalker2_validate;miRTarBase -1.1805741007743 8.25862902187063e-24 22450326 We further identified that miR-25 directly targeted CDH1 3'-untranslated region 3'UTR and repressed the expression of CDH1; These results for the first time demonstrate that miR-25 promotes ESCC cell migration and invasion by suppressing CDH1 expression cell migration esophageal cancer hsa-miR-330-3p CDH1 0.912906550436308 3.35037014057665e-13 -1.86435402516367 3.67522478130053e-23 MirTarget;mirMAP -0.527292744686461 7.55954408948366e-10 NA NA NA hsa-miR-330-5p CDH1 1.44960468659754 2.12131210588035e-45 -1.86435402516367 3.67522478130053e-23 miRanda -0.854206967701038 6.60614118510542e-22 NA NA NA hsa-miR-338-3p CDH1 0.906250377628867 2.76970900371139e-15 -1.86435402516367 3.67522478130053e-23 MirTarget;miRanda -0.519886629575362 1.34368613515985e-08 NA NA NA hsa-miR-339-5p CDH1 0.322848334531193 0.0117281778821612 -1.86435402516367 3.67522478130053e-23 miRanda -0.304014480389989 0.000453629161527723 NA NA NA hsa-miR-342-3p CDH1 1.4124432570595 1.07208971556131e-28 -1.86435402516367 3.67522478130053e-23 miRanda -0.71905830302145 1.69027625713663e-21 NA NA NA hsa-miR-590-3p CDH1 1.13702599385212 3.53435739887793e-22 -1.86435402516367 3.67522478130053e-23 miRanda -0.640760763920172 9.02682443255485e-14 NA NA NA hsa-miR-616-5p CDH1 0.913426384742148 3.78418389333709e-09 -1.86435402516367 3.67522478130053e-23 MirTarget;mirMAP -0.283950566085914 6.29283362433263e-05 NA NA NA hsa-miR-92a-3p CDH1 0.178194888895831 0.0088835082650834 -1.86435402516367 3.67522478130053e-23 miRTarBase -0.676921685311385 4.07862232519796e-05 25515201;21148309 The expression of miR-92a PTEN and E-cadherin was analyzed by real-time PCR; No any association of miR-92a and E-cadherin was found p = 0.128;We further demonstrated that miR-92a directly targeted the CDH1 3'-UTR and repressed the expression of CDH1 a tumor metastasis suppressor; In addition restoring of miR-92a-resistant CDH1 expression in miR-92a-overexpression cells recovered the pro-metastasis activity of miR-92a; Taken together we demonstrated that miR-92a promotes ESCC cell migration and invasion at least partially via suppression of CDH1 expression and patients with up-regulated miR-92a are prone to lymph node metastasis and thus have poor prognosis ;metastasis;worse prognosis;cell migration colorectal cancer;esophageal cancer hsa-miR-15b-3p CRB1 1.49422666971434 5.44139893275088e-29 -0.843205463944227 4.17793790715281e-07 mirMAP -0.256926062006253 5.49663061076463e-05 NA NA NA hsa-miR-16-2-3p CRB1 1.3046118743965 4.17207934608428e-19 -0.843205463944227 4.17793790715281e-07 mirMAP -0.255777841670536 2.03552325803581e-05 NA NA NA hsa-miR-181b-5p CRB1 1.49054296272357 3.69051660739368e-41 -0.843205463944227 4.17793790715281e-07 mirMAP -0.209399627994925 0.00483148155721356 NA NA NA hsa-miR-21-5p CRB1 2.51462371613332 3.30620591950316e-66 -0.843205463944227 4.17793790715281e-07 mirMAP -0.248984879079962 1.26462627248147e-06 NA NA NA hsa-miR-23a-3p CRB1 0.761438723382355 4.09310879199257e-27 -0.843205463944227 4.17793790715281e-07 mirMAP -0.323030030909834 0.00894314766429483 NA NA NA hsa-miR-28-3p CRB1 1.01277915413238 1.8655970171461e-43 -0.843205463944227 4.17793790715281e-07 mirMAP -0.474627638773191 2.14774009921746e-05 NA NA NA hsa-miR-330-5p CRB1 1.44960468659754 2.12131210588035e-45 -0.843205463944227 4.17793790715281e-07 miRanda -0.36946734918475 2.55894643528193e-06 NA NA NA hsa-miR-340-5p CRB1 1.14479851941741 2.91936881701444e-15 -0.843205463944227 4.17793790715281e-07 mirMAP -0.192861213812721 0.00175593810463079 NA NA NA hsa-miR-342-3p CRB1 1.4124432570595 1.07208971556131e-28 -0.843205463944227 4.17793790715281e-07 miRanda -0.270025266062392 5.58558911757111e-05 NA NA NA hsa-miR-361-5p CRB1 0.0514169367202078 0.382929376393199 -0.843205463944227 4.17793790715281e-07 miRanda -0.451286925560321 0.00566533283771346 NA NA NA hsa-miR-374a-3p CRB1 1.13863935833993 2.79089304015401e-44 -0.843205463944227 4.17793790715281e-07 mirMAP -0.464665213385891 3.0170310647509e-06 NA NA NA hsa-miR-374a-5p CRB1 0.543061152108237 2.19403097299769e-14 -0.843205463944227 4.17793790715281e-07 mirMAP -0.498735908922973 8.97138851738339e-05 NA NA NA hsa-miR-374b-5p CRB1 0.0804104684417872 0.365593963035077 -0.843205463944227 4.17793790715281e-07 mirMAP -0.295433459104343 0.00548071130501685 NA NA NA hsa-miR-452-5p CRB1 2.05325688842141 2.82238393643084e-40 -0.843205463944227 4.17793790715281e-07 mirMAP -0.150485570045574 0.00476990683581626 NA NA NA hsa-miR-590-3p CRB1 1.13702599385212 3.53435739887793e-22 -0.843205463944227 4.17793790715281e-07 miRanda;mirMAP -0.202171609815955 0.00689371179963599 NA NA NA hsa-miR-590-5p CRB1 0.709763558412506 1.11883921359361e-11 -0.843205463944227 4.17793790715281e-07 miRanda;mirMAP -0.270046092987714 0.00189273954112521 NA NA NA hsa-miR-616-5p CRB1 0.913426384742148 3.78418389333709e-09 -0.843205463944227 4.17793790715281e-07 mirMAP -0.200139501542628 0.000811431190035623 NA NA NA hsa-let-7b-5p CRB2 0.770868211539597 6.63408323707647e-21 -2.60563167332109 6.75197103156313e-14 miRNATAP -0.712926363995827 0.00194838806585161 NA NA NA hsa-miR-140-3p CRB2 0.989350547007025 6.14964028267239e-25 -2.60563167332109 6.75197103156313e-14 MirTarget -0.678731713674259 0.000449612377768614 NA NA NA hsa-miR-452-3p CRB2 1.72039996672257 1.35748079442153e-22 -2.60563167332109 6.75197103156313e-14 MirTarget -0.450748003049188 2.72095853226262e-05 NA NA NA hsa-miR-1468-5p CSNK1D -0.311126383179539 0.00979113361106863 0.0973363302381669 0.0785364887505314 MirTarget -0.120046292535599 1.48665697463529e-06 NA NA NA hsa-miR-149-5p CSNK1E -1.95790336710741 8.46371715052367e-27 1.01039126608085 6.48810251758301e-40 miRNAWalker2_validate -0.155001487088013 3.55448762097709e-11 NA NA NA hsa-miR-30a-3p CSNK1E -0.955360819934585 1.97009535429185e-20 1.01039126608085 6.48810251758301e-40 miRNATAP -0.347530700463454 7.93808645307933e-17 NA NA NA hsa-miR-30c-5p CSNK1E -1.08783070774238 2.02505402525786e-24 1.01039126608085 6.48810251758301e-40 miRNAWalker2_validate -0.328790062078608 1.44814431919771e-16 NA NA NA hsa-miR-30d-3p CSNK1E -0.249777194282131 0.00235356711813496 1.01039126608085 6.48810251758301e-40 miRNATAP -0.154842507840326 0.00812535868602463 NA NA NA hsa-miR-362-3p CSNK1E -0.753214251798232 3.0025661608035e-07 1.01039126608085 6.48810251758301e-40 miRanda -0.111227437500845 0.000707090480565381 NA NA NA hsa-miR-429 CSNK1E -2.16569233119434 2.66862243626443e-37 1.01039126608085 6.48810251758301e-40 miRNATAP -0.205975413297079 4.34082584281407e-18 NA NA NA hsa-miR-132-3p CTGF 0.291409674711894 0.000912684337101876 -1.46941302681258 6.60266339692734e-19 MirTarget -0.346787901898476 0.00164022930627692 NA NA NA hsa-miR-19a-3p CTGF 0.722913586880779 2.76301458932381e-10 -1.46941302681258 6.60266339692734e-19 MirTarget;miRNATAP -0.276886343373103 0.000748854130778202 NA NA NA hsa-miR-361-3p CTGF 1.08992546227594 1.13197240706704e-36 -1.46941302681258 6.60266339692734e-19 MirTarget;miRNATAP -0.472505972141155 2.09550653361974e-06 NA NA NA hsa-miR-590-3p CTGF 1.13702599385212 3.53435739887793e-22 -1.46941302681258 6.60266339692734e-19 PITA;miRanda -0.441939578627256 5.41825255697319e-09 NA NA NA hsa-miR-7-1-3p CTGF 0.544601828025304 5.33830451326047e-07 -1.46941302681258 6.60266339692734e-19 MirTarget -0.296407368695659 0.000720347913179578 NA NA NA hsa-miR-140-5p CTNNA1 0.504309496243674 3.09884038729031e-11 -0.0716131427007802 0.157577442757864 miRanda -0.116197891628376 0.00115613054573793 NA NA NA hsa-miR-28-5p CTNNB1 0.461962042257226 3.32424690573327e-11 -0.220709664881213 0.00129454639929481 miRanda -0.146958614625593 0.0061343910985911 NA NA NA hsa-miR-34a-5p CTNNB1 1.07544567720768 1.81510842038009e-20 -0.220709664881213 0.00129454639929481 miRNAWalker2_validate -0.145558388061578 1.77642044170244e-06 NA NA NA hsa-miR-589-5p CTNNB1 0.696241532021631 5.26958362886071e-16 -0.220709664881213 0.00129454639929481 miRNATAP -0.212332596763495 4.03527705083217e-07 NA NA NA hsa-miR-590-3p CTNNB1 1.13702599385212 3.53435739887793e-22 -0.220709664881213 0.00129454639929481 miRanda -0.16927364598531 1.27863235456847e-08 NA NA NA hsa-miR-126-5p DLG1 0.785607261431085 5.77058629454465e-13 -0.502475009903324 8.52259635987809e-14 MirTarget;mirMAP -0.111354607895656 0.00109978286444851 NA NA NA hsa-miR-193a-3p DLG1 0.849206638484406 3.68101781083335e-14 -0.502475009903324 8.52259635987809e-14 miRanda -0.162547216805266 6.80612613948289e-07 NA NA NA hsa-miR-21-5p DLG1 2.51462371613332 3.30620591950316e-66 -0.502475009903324 8.52259635987809e-14 miRNAWalker2_validate -0.141640696653137 9.70347565321326e-12 NA NA NA hsa-miR-320a DLG1 0.412740558379182 2.02929519701706e-05 -0.502475009903324 8.52259635987809e-14 miRanda -0.114464092436832 0.00381211180008351 NA NA NA hsa-miR-590-3p DLG1 1.13702599385212 3.53435739887793e-22 -0.502475009903324 8.52259635987809e-14 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.137966163195919 6.09578108447021e-06 NA NA NA hsa-miR-590-5p DLG1 0.709763558412506 1.11883921359361e-11 -0.502475009903324 8.52259635987809e-14 miRanda -0.121531630889198 0.00067369906354281 NA NA NA hsa-miR-1301-3p DLG2 0.393537638993954 0.000390498879474539 -2.23241862907658 1.79863712506275e-29 MirTarget -0.479394893924895 6.97527043232617e-06 NA NA NA hsa-miR-130b-5p DLG2 0.92990617673277 3.75880436852717e-12 -2.23241862907658 1.79863712506275e-29 miRNATAP -0.497853030155782 4.55467146511751e-09 NA NA NA hsa-miR-140-5p DLG2 0.504309496243674 3.09884038729031e-11 -2.23241862907658 1.79863712506275e-29 PITA;miRanda;miRNATAP -0.610099424099776 7.48136568565131e-05 NA NA NA hsa-miR-142-3p DLG2 1.88928758773299 2.72985643829893e-22 -2.23241862907658 1.79863712506275e-29 miRanda -0.366910940123107 5.50988622950177e-11 NA NA NA hsa-miR-142-5p DLG2 1.88417391525707 1.2096808039882e-27 -2.23241862907658 1.79863712506275e-29 PITA;miRNATAP -0.444109867005339 5.01591825520403e-13 NA NA NA hsa-miR-146b-5p DLG2 1.40714170253819 2.9559871816487e-12 -2.23241862907658 1.79863712506275e-29 miRanda -0.29672521236403 1.50716365473571e-07 NA NA NA hsa-miR-148b-3p DLG2 0.346011252093377 4.27203463315056e-06 -2.23241862907658 1.79863712506275e-29 miRNAWalker2_validate;MirTarget -0.618568711722348 9.33275530364267e-05 NA NA NA hsa-miR-148b-5p DLG2 0.269550343699955 0.0383631776794927 -2.23241862907658 1.79863712506275e-29 mirMAP -0.265279724637746 0.00528932150269817 NA NA NA hsa-miR-15b-3p DLG2 1.49422666971434 5.44139893275088e-29 -2.23241862907658 1.79863712506275e-29 mirMAP -0.645411557592095 2.03442041785737e-16 NA NA NA hsa-miR-16-2-3p DLG2 1.3046118743965 4.17207934608428e-19 -2.23241862907658 1.79863712506275e-29 mirMAP -0.564534252468365 4.04818584063884e-14 NA NA NA hsa-miR-17-5p DLG2 0.494260110870015 3.8348005261e-09 -2.23241862907658 1.79863712506275e-29 mirMAP -0.84101161460688 1.01702338969612e-09 NA NA NA hsa-miR-185-5p DLG2 1.05056378692621 1.31174187880682e-22 -2.23241862907658 1.79863712506275e-29 MirTarget;miRNATAP -0.611338652734023 2.37176014366773e-09 NA NA NA hsa-miR-186-5p DLG2 0.507217561043443 9.04455748270995e-10 -2.23241862907658 1.79863712506275e-29 mirMAP -0.719517797724765 3.01490149889225e-07 NA NA NA hsa-miR-195-3p DLG2 0.808592887366705 6.8151241038711e-09 -2.23241862907658 1.79863712506275e-29 mirMAP -0.281804943165854 0.00084935583043786 NA NA NA hsa-miR-19a-3p DLG2 0.722913586880779 2.76301458932381e-10 -2.23241862907658 1.79863712506275e-29 mirMAP -0.552253699318743 3.77628246909292e-08 NA NA NA hsa-miR-19b-3p DLG2 0.195940928879427 0.0300512922542325 -2.23241862907658 1.79863712506275e-29 mirMAP -0.58467217033537 1.01552699005437e-05 NA NA NA hsa-miR-20a-5p DLG2 0.702602695798242 4.06372887613329e-13 -2.23241862907658 1.79863712506275e-29 mirMAP -0.671079118281527 1.18710738285417e-08 NA NA NA hsa-miR-224-3p DLG2 0.918780460857403 2.47005991706282e-07 -2.23241862907658 1.79863712506275e-29 MirTarget -0.283225464176525 3.05090322496512e-05 NA NA NA hsa-miR-23a-3p DLG2 0.761438723382355 4.09310879199257e-27 -2.23241862907658 1.79863712506275e-29 MirTarget;miRNATAP -1.20524664157796 1.95559286918679e-15 NA NA NA hsa-miR-24-3p DLG2 0.173813044685099 0.00565259443420961 -2.23241862907658 1.79863712506275e-29 MirTarget -0.678800278358882 0.00045588240393578 NA NA NA hsa-miR-25-3p DLG2 1.12016166564779 3.79069348635778e-48 -2.23241862907658 1.79863712506275e-29 mirMAP -1.11152236701659 5.71570016072401e-18 NA NA NA hsa-miR-28-5p DLG2 0.461962042257226 3.32424690573327e-11 -2.23241862907658 1.79863712506275e-29 mirMAP -0.771797619645119 4.20403970689136e-06 NA NA NA hsa-miR-3127-5p DLG2 0.952801473575318 5.81162987769266e-14 -2.23241862907658 1.79863712506275e-29 mirMAP -0.594724377542205 1.15100293914356e-10 NA NA NA hsa-miR-32-5p DLG2 0.407826130035097 7.26884631998646e-06 -2.23241862907658 1.79863712506275e-29 mirMAP -0.462191766489967 0.000406107609001959 NA NA NA hsa-miR-320a DLG2 0.412740558379182 2.02929519701706e-05 -2.23241862907658 1.79863712506275e-29 PITA;miRanda;mirMAP;miRNATAP -0.508269027636282 3.22286724173989e-05 NA NA NA hsa-miR-320b DLG2 0.300497419754843 0.0245219177384172 -2.23241862907658 1.79863712506275e-29 PITA;miRanda;mirMAP;miRNATAP -0.364066338520217 4.39686542352731e-05 NA NA NA hsa-miR-330-3p DLG2 0.912906550436308 3.35037014057665e-13 -2.23241862907658 1.79863712506275e-29 PITA;mirMAP -0.320698304407637 0.000645022219892367 NA NA NA hsa-miR-338-3p DLG2 0.906250377628867 2.76970900371139e-15 -2.23241862907658 1.79863712506275e-29 PITA;mirMAP;miRNATAP -0.28393493817219 0.00462196348987431 NA NA NA hsa-miR-361-3p DLG2 1.08992546227594 1.13197240706704e-36 -2.23241862907658 1.79863712506275e-29 PITA;miRNATAP -1.0004348263072 4.50054388830144e-17 NA NA NA hsa-miR-3613-5p DLG2 1.6648190889407 3.78720979041391e-41 -2.23241862907658 1.79863712506275e-29 MirTarget;miRNATAP -0.690640371938217 2.79265487641577e-17 NA NA NA hsa-miR-374b-3p DLG2 0.611842481331529 3.85718194756943e-07 -2.23241862907658 1.79863712506275e-29 mirMAP -0.472526030856137 2.51355179197453e-06 NA NA NA hsa-miR-484 DLG2 0.571987778099603 9.67278224458421e-10 -2.23241862907658 1.79863712506275e-29 MirTarget;PITA -0.562853784282841 6.18729097337869e-06 NA NA NA hsa-miR-576-5p DLG2 1.06681109513983 5.69294424466526e-24 -2.23241862907658 1.79863712506275e-29 PITA;mirMAP -0.744012080140599 3.46499156748694e-13 NA NA NA hsa-miR-590-3p DLG2 1.13702599385212 3.53435739887793e-22 -2.23241862907658 1.79863712506275e-29 PITA;miRanda;mirMAP -0.656430506202944 1.51782802401453e-12 NA NA NA hsa-miR-590-5p DLG2 0.709763558412506 1.11883921359361e-11 -2.23241862907658 1.79863712506275e-29 PITA;miRanda -0.633652234904003 6.88700032950342e-09 NA NA NA hsa-miR-592 DLG2 2.6404220268798 8.81369998128794e-32 -2.23241862907658 1.79863712506275e-29 MirTarget;miRNATAP -0.247775549360683 2.13369131022999e-07 NA NA NA hsa-miR-616-5p DLG2 0.913426384742148 3.78418389333709e-09 -2.23241862907658 1.79863712506275e-29 mirMAP -0.304138138513705 6.72596308947461e-05 NA NA NA hsa-miR-7-1-3p DLG2 0.544601828025304 5.33830451326047e-07 -2.23241862907658 1.79863712506275e-29 MirTarget -0.49765001912733 3.96250337992153e-06 NA NA NA hsa-miR-92a-3p DLG2 0.178194888895831 0.0088835082650834 -2.23241862907658 1.79863712506275e-29 mirMAP -0.714510314456925 5.67663047456806e-05 NA NA NA hsa-miR-92b-3p DLG2 0.418630595140165 6.50466149211154e-05 -2.23241862907658 1.79863712506275e-29 mirMAP -0.546433689370818 1.17493497792509e-06 NA NA NA hsa-miR-93-3p DLG2 0.379664250785728 9.76327751780657e-05 -2.23241862907658 1.79863712506275e-29 MirTarget;miRNATAP -0.428156228260402 0.000461673557669825 NA NA NA hsa-miR-142-5p DLG3 1.88417391525707 1.2096808039882e-27 -0.549340849371914 3.12197119106664e-18 PITA;mirMAP -0.179480007696546 4.73833567560684e-23 NA NA NA hsa-miR-185-3p DLG3 0.993379985307475 2.62011454953707e-13 -0.549340849371914 3.12197119106664e-18 MirTarget;miRNATAP -0.107198772017798 4.23483438049213e-05 NA NA NA hsa-miR-186-5p DLG3 0.507217561043443 9.04455748270995e-10 -0.549340849371914 3.12197119106664e-18 miRNAWalker2_validate -0.235412874465457 3.72871377995242e-08 NA NA NA hsa-miR-197-3p DLG3 0.297760714271229 0.00102679606305048 -0.549340849371914 3.12197119106664e-18 mirMAP -0.107694474695606 0.00781654039979585 NA NA NA hsa-miR-330-5p DLG3 1.44960468659754 2.12131210588035e-45 -0.549340849371914 3.12197119106664e-18 miRanda;miRNATAP -0.274072337301309 7.76277888812249e-21 NA NA NA hsa-miR-342-3p DLG3 1.4124432570595 1.07208971556131e-28 -0.549340849371914 3.12197119106664e-18 miRanda -0.238093879876079 7.156478548257e-22 NA NA NA hsa-miR-374a-5p DLG3 0.543061152108237 2.19403097299769e-14 -0.549340849371914 3.12197119106664e-18 MirTarget -0.345695376991105 1.0417917911923e-12 NA NA NA hsa-miR-421 DLG3 0.313155739887734 0.020433534776003 -0.549340849371914 3.12197119106664e-18 mirMAP -0.120629527963982 1.38651741468224e-05 NA NA NA hsa-miR-590-3p DLG3 1.13702599385212 3.53435739887793e-22 -0.549340849371914 3.12197119106664e-18 miRanda -0.187633730433769 4.55561254620016e-11 NA NA NA hsa-miR-629-3p DLG3 1.09330044556689 2.9533160808356e-14 -0.549340849371914 3.12197119106664e-18 MirTarget;miRNATAP -0.116721063796998 2.10271291172517e-06 NA NA NA hsa-miR-93-3p DLG3 0.379664250785728 9.76327751780657e-05 -0.549340849371914 3.12197119106664e-18 mirMAP -0.135818720785378 0.000273392926421174 NA NA NA hsa-miR-30b-3p DLG4 -1.64703050862226 1.89878531036464e-31 0.187149322238145 0.0619914347688762 MirTarget -0.152859674181034 1.62915743343129e-05 NA NA NA hsa-miR-455-3p DLG4 0.171798655137046 0.261841668213493 0.187149322238145 0.0619914347688762 MirTarget;PITA;miRNATAP -0.139672820387595 0.000102829872707862 NA NA NA hsa-miR-616-5p DLG4 0.913426384742148 3.78418389333709e-09 0.187149322238145 0.0619914347688762 MirTarget;miRNATAP -0.139916865003058 7.00496546437337e-05 NA NA NA hsa-miR-29b-2-5p DVL3 -0.297854154636098 0.00260919277325581 0.0517387826509061 0.331393289501179 MirTarget -0.146756419924725 4.57749287388624e-07 NA NA NA hsa-miR-106b-5p FBXW11 1.07509411417907 2.11739194181878e-36 -0.382333893897273 1.04530841856519e-08 miRNATAP -0.338043846287292 1.65431880521891e-19 NA NA NA hsa-miR-130b-3p FBXW11 1.12788913578446 2.939369462276e-16 -0.382333893897273 1.04530841856519e-08 MirTarget -0.189261540770142 4.38241409739157e-14 NA NA NA hsa-miR-142-5p FBXW11 1.88417391525707 1.2096808039882e-27 -0.382333893897273 1.04530841856519e-08 PITA -0.108241212306481 3.21826120985363e-08 NA NA NA hsa-miR-16-1-3p FBXW11 1.51429140700091 3.17219833254498e-37 -0.382333893897273 1.04530841856519e-08 MirTarget -0.104073201173029 0.000261853883561163 NA NA NA hsa-miR-16-5p FBXW11 0.934012514027655 4.85417898318515e-24 -0.382333893897273 1.04530841856519e-08 miRNAWalker2_validate -0.147206592375098 9.85425588929349e-05 NA NA NA hsa-miR-17-5p FBXW11 0.494260110870015 3.8348005261e-09 -0.382333893897273 1.04530841856519e-08 TargetScan;miRNATAP -0.156412997952024 0.000374404469491881 NA NA NA hsa-miR-19a-3p FBXW11 0.722913586880779 2.76301458932381e-10 -0.382333893897273 1.04530841856519e-08 MirTarget -0.140150302474319 9.89343645640583e-06 NA NA NA hsa-miR-19b-3p FBXW11 0.195940928879427 0.0300512922542325 -0.382333893897273 1.04530841856519e-08 MirTarget -0.176331628905591 2.19567174934386e-05 NA NA NA hsa-miR-20a-5p FBXW11 0.702602695798242 4.06372887613329e-13 -0.382333893897273 1.04530841856519e-08 miRNATAP -0.150046860185627 5.85922335239707e-05 NA NA NA hsa-miR-301a-3p FBXW11 0.259400847075798 0.0216890736701418 -0.382333893897273 1.04530841856519e-08 MirTarget -0.123526207315598 0.000194838076744278 NA NA NA hsa-miR-320a FBXW11 0.412740558379182 2.02929519701706e-05 -0.382333893897273 1.04530841856519e-08 PITA;miRanda -0.111000719395279 0.004005215483286 NA NA NA hsa-miR-330-3p FBXW11 0.912906550436308 3.35037014057665e-13 -0.382333893897273 1.04530841856519e-08 MirTarget;PITA;miRNATAP -0.103576784548662 0.000432831545200346 NA NA NA hsa-miR-374a-5p FBXW11 0.543061152108237 2.19403097299769e-14 -0.382333893897273 1.04530841856519e-08 mirMAP -0.140233760313555 0.00639802178124422 NA NA NA hsa-miR-454-3p FBXW11 0.68285296887698 1.17407812677787e-08 -0.382333893897273 1.04530841856519e-08 MirTarget -0.125774144594795 3.83345002298946e-05 NA NA NA hsa-miR-590-3p FBXW11 1.13702599385212 3.53435739887793e-22 -0.382333893897273 1.04530841856519e-08 mirMAP -0.160344943680569 5.66145570232005e-08 NA NA NA hsa-miR-93-5p FBXW11 1.37365940377595 2.37567548683245e-46 -0.382333893897273 1.04530841856519e-08 miRNATAP -0.175690890211501 1.47862966783533e-07 NA NA NA hsa-miR-126-5p FGF1 0.785607261431085 5.77058629454465e-13 -3.80115931488584 6.45925676739727e-49 mirMAP -0.412699157217257 0.00526602775124141 NA NA NA hsa-miR-146b-3p FGF1 1.20941495066078 2.12939149602665e-10 -3.80115931488584 6.45925676739727e-49 miRNATAP -0.412681804700488 8.7577650210875e-07 NA NA NA hsa-miR-16-1-3p FGF1 1.51429140700091 3.17219833254498e-37 -3.80115931488584 6.45925676739727e-49 mirMAP -0.964767375204906 2.41440232347677e-15 NA NA NA hsa-miR-186-5p FGF1 0.507217561043443 9.04455748270995e-10 -3.80115931488584 6.45925676739727e-49 mirMAP -1.1691556044543 1.5936381390255e-09 NA NA NA hsa-miR-18a-5p FGF1 0.936704393213466 1.05064580570579e-10 -3.80115931488584 6.45925676739727e-49 MirTarget -0.380773292559268 0.00062635862331619 NA NA NA hsa-miR-193a-3p FGF1 0.849206638484406 3.68101781083335e-14 -3.80115931488584 6.45925676739727e-49 PITA -0.799485713529985 1.34176070169954e-08 NA NA NA hsa-miR-21-5p FGF1 2.51462371613332 3.30620591950316e-66 -3.80115931488584 6.45925676739727e-49 MirTarget -1.0333718022015 1.64441254488335e-35 NA NA NA hsa-miR-2355-5p FGF1 1.57515081110162 3.54962327490702e-48 -3.80115931488584 6.45925676739727e-49 MirTarget -1.06613568021987 4.20053987792956e-17 NA NA NA hsa-miR-28-5p FGF1 0.461962042257226 3.32424690573327e-11 -3.80115931488584 6.45925676739727e-49 miRanda -0.947270161202561 5.17246250727041e-05 NA NA NA hsa-miR-320a FGF1 0.412740558379182 2.02929519701706e-05 -3.80115931488584 6.45925676739727e-49 miRanda -0.542494284439551 0.00150132216990968 NA NA NA hsa-miR-330-5p FGF1 1.44960468659754 2.12131210588035e-45 -3.80115931488584 6.45925676739727e-49 miRanda;miRNATAP -1.30237436907411 7.22656393944219e-23 NA NA NA hsa-miR-374a-3p FGF1 1.13863935833993 2.79089304015401e-44 -3.80115931488584 6.45925676739727e-49 mirMAP -1.40971713192021 1.79713277496189e-16 NA NA NA hsa-miR-3913-5p FGF1 0.136365354811444 0.24239516424369 -3.80115931488584 6.45925676739727e-49 mirMAP -0.458269193077043 0.00234831890309927 NA NA NA hsa-miR-484 FGF1 0.571987778099603 9.67278224458421e-10 -3.80115931488584 6.45925676739727e-49 MirTarget;PITA;miRNATAP -0.539151528053616 0.00200972026686984 NA NA NA hsa-miR-550a-5p FGF1 0.764341426122997 7.62129848116256e-09 -3.80115931488584 6.45925676739727e-49 MirTarget -0.542780642335613 1.80477226060982e-05 NA NA NA hsa-miR-576-5p FGF1 1.06681109513983 5.69294424466526e-24 -3.80115931488584 6.45925676739727e-49 PITA;mirMAP -1.26887442737172 6.80528442258741e-20 NA NA NA hsa-miR-590-5p FGF1 0.709763558412506 1.11883921359361e-11 -3.80115931488584 6.45925676739727e-49 MirTarget;miRanda;miRNATAP -0.760247687860989 6.80195819553776e-07 NA NA NA hsa-miR-629-5p FGF1 1.73389921851483 5.39614356468007e-48 -3.80115931488584 6.45925676739727e-49 MirTarget -1.38540287626161 3.01408249241889e-38 NA NA NA hsa-miR-330-5p FRMD1 1.44960468659754 2.12131210588035e-45 -2.48800706171669 6.03692359251838e-10 miRanda -1.24286865806669 4.17193859307735e-11 NA NA NA hsa-miR-342-5p FRMD1 1.37011183051517 4.99462376051624e-28 -2.48800706171669 6.03692359251838e-10 mirMAP -0.495009604103863 0.0031494349335308 NA NA NA hsa-miR-183-5p FRMD6 -1.21596931064487 1.31473205758898e-08 0.2039129802354 0.0629210786657724 MirTarget;miRNATAP -0.105015821040555 0.000130623051159275 NA NA NA hsa-miR-200a-3p FRMD6 -1.43409013664263 2.00188483717828e-20 0.2039129802354 0.0629210786657724 MirTarget;miRNATAP -0.210657449489794 4.75678917831066e-09 NA NA NA hsa-miR-200b-3p FRMD6 -1.70383252137161 2.38979336321755e-30 0.2039129802354 0.0629210786657724 TargetScan -0.213298063707729 3.88766754988413e-09 NA NA NA hsa-miR-29b-2-5p FRMD6 -0.297854154636098 0.00260919277325581 0.2039129802354 0.0629210786657724 MirTarget -0.195875628766563 0.00134489463693719 NA NA NA hsa-miR-30a-5p FRMD6 -0.778411951775343 2.73322451127932e-16 0.2039129802354 0.0629210786657724 MirTarget;miRNATAP -0.364890709571323 9.29379550385556e-10 NA NA NA hsa-miR-30b-5p FRMD6 -1.18330589477119 6.8341618466966e-27 0.2039129802354 0.0629210786657724 MirTarget -0.217216791287268 1.53063675731008e-05 NA NA NA hsa-miR-30c-5p FRMD6 -1.08783070774238 2.02505402525786e-24 0.2039129802354 0.0629210786657724 MirTarget;miRNATAP -0.186360529666824 0.000395569491897809 NA NA NA hsa-miR-30d-5p FRMD6 -0.202727675788184 0.00659067084745794 0.2039129802354 0.0629210786657724 MirTarget;miRNATAP -0.322013009143658 7.63666053976813e-05 NA NA NA hsa-miR-30e-5p FRMD6 -0.0905907245198101 0.21196704484334 0.2039129802354 0.0629210786657724 MirTarget -0.295017995666153 0.000472531893305922 NA NA NA hsa-miR-429 FRMD6 -2.16569233119434 2.66862243626443e-37 0.2039129802354 0.0629210786657724 miRanda;miRNATAP -0.174558909893322 2.00428158474222e-08 NA NA NA hsa-miR-200a-5p FZD1 -1.36295040293874 1.31587720312419e-22 1.18897996620487 6.40075199454189e-23 MirTarget -0.237303432841978 5.05545143933163e-07 NA NA NA hsa-miR-200b-5p FZD1 -1.46985752435972 3.43232443788022e-27 1.18897996620487 6.40075199454189e-23 MirTarget -0.284295772752584 2.28979329100603e-09 NA NA NA hsa-miR-29a-3p FZD1 -0.431613225927952 4.10166815070288e-08 1.18897996620487 6.40075199454189e-23 mirMAP -0.630692071690045 4.00733131833338e-13 NA NA NA hsa-miR-29b-3p FZD1 -0.228125979913806 0.0271621721891603 1.18897996620487 6.40075199454189e-23 mirMAP -0.344528946983843 4.88250386701375e-07 NA NA NA hsa-miR-29c-3p FZD1 -0.238671318446745 0.0141475322347596 1.18897996620487 6.40075199454189e-23 mirMAP -0.343764763499162 2.40176712567126e-06 NA NA NA hsa-miR-335-5p FZD1 -2.09515619961552 1.03765771499548e-25 1.18897996620487 6.40075199454189e-23 miRNAWalker2_validate -0.196968577894013 1.46544128662299e-09 NA NA NA hsa-miR-514a-3p FZD1 -3.60916038800272 7.44698991540685e-35 1.18897996620487 6.40075199454189e-23 MirTarget -0.11508280709999 8.81799422383285e-08 NA NA NA hsa-miR-577 FZD1 -1.48881999472397 7.03080165111147e-10 1.18897996620487 6.40075199454189e-23 MirTarget;PITA -0.124935867613655 1.28983332156977e-05 NA NA NA hsa-miR-107 FZD10 0.140046250553248 0.0943611632552367 -0.0105536578305034 0.964908170337496 miRanda -1.01467739461736 6.43538981376536e-11 NA NA NA hsa-miR-32-5p FZD10 0.407826130035097 7.26884631998646e-06 -0.0105536578305034 0.964908170337496 miRNATAP -0.494045091233897 0.000609923028418673 NA NA NA hsa-miR-455-3p FZD10 0.171798655137046 0.261841668213493 -0.0105536578305034 0.964908170337496 PITA;miRNATAP -0.396087264547542 3.65323026992865e-06 NA NA NA hsa-miR-98-5p FZD10 0.0569715596189075 0.450575962846765 -0.0105536578305034 0.964908170337496 miRNAWalker2_validate -0.795249061355186 6.24048869573494e-06 NA NA NA hsa-let-7b-5p FZD3 0.770868211539597 6.63408323707647e-21 -1.04311294572608 4.3896749999504e-25 MirTarget;miRNATAP -0.297267628507525 1.49550298428553e-05 NA NA NA hsa-let-7f-1-3p FZD3 0.477913872379336 4.46669616865068e-05 -1.04311294572608 4.3896749999504e-25 MirTarget -0.181784802640275 0.000960085987151416 NA NA NA hsa-let-7i-5p FZD3 0.911372377723717 7.11483853341932e-31 -1.04311294572608 4.3896749999504e-25 MirTarget;miRNATAP -0.262906938475552 0.000154654474446727 NA NA NA hsa-miR-103a-3p FZD3 0.779373475434461 7.37867196796994e-20 -1.04311294572608 4.3896749999504e-25 MirTarget -0.439796779902477 1.19874694107304e-11 NA NA NA hsa-miR-106b-5p FZD3 1.07509411417907 2.11739194181878e-36 -1.04311294572608 4.3896749999504e-25 MirTarget;mirMAP;miRNATAP -0.473520236033418 6.70573413605151e-15 NA NA NA hsa-miR-126-5p FZD3 0.785607261431085 5.77058629454465e-13 -1.04311294572608 4.3896749999504e-25 mirMAP -0.190812915606903 0.000327016170622135 NA NA NA hsa-miR-130b-3p FZD3 1.12788913578446 2.939369462276e-16 -1.04311294572608 4.3896749999504e-25 mirMAP -0.142779834574591 0.000579890288086553 NA NA NA hsa-miR-140-5p FZD3 0.504309496243674 3.09884038729031e-11 -1.04311294572608 4.3896749999504e-25 miRanda -0.351506784761809 4.83378523634811e-06 NA NA NA hsa-miR-142-3p FZD3 1.88928758773299 2.72985643829893e-22 -1.04311294572608 4.3896749999504e-25 miRanda -0.152723232142726 7.0877698230222e-08 NA NA NA hsa-miR-143-3p FZD3 0.544259011512089 1.71102635165867e-05 -1.04311294572608 4.3896749999504e-25 mirMAP -0.143529127901911 0.00223362387765262 NA NA NA hsa-miR-146a-5p FZD3 1.04938133739924 7.51013231709992e-12 -1.04311294572608 4.3896749999504e-25 MirTarget -0.195760662579759 1.6093331134118e-07 NA NA NA hsa-miR-155-5p FZD3 3.26274490570809 5.06841441826518e-51 -1.04311294572608 4.3896749999504e-25 mirMAP -0.190822068802253 1.59957216164852e-17 NA NA NA hsa-miR-16-1-3p FZD3 1.51429140700091 3.17219833254498e-37 -1.04311294572608 4.3896749999504e-25 mirMAP -0.268015971151015 2.24170345227388e-09 NA NA NA hsa-miR-16-2-3p FZD3 1.3046118743965 4.17207934608428e-19 -1.04311294572608 4.3896749999504e-25 mirMAP -0.205429840568988 7.71735410668427e-08 NA NA NA hsa-miR-17-5p FZD3 0.494260110870015 3.8348005261e-09 -1.04311294572608 4.3896749999504e-25 MirTarget;TargetScan;mirMAP;miRNATAP -0.184590941966793 0.00896721340153011 NA NA NA hsa-miR-181a-5p FZD3 1.11111114875339 3.97880443756442e-29 -1.04311294572608 4.3896749999504e-25 mirMAP -0.36590351075096 1.23522048878962e-11 NA NA NA hsa-miR-181b-5p FZD3 1.49054296272357 3.69051660739368e-41 -1.04311294572608 4.3896749999504e-25 mirMAP -0.341760147449408 1.12987877908813e-13 NA NA NA hsa-miR-186-5p FZD3 0.507217561043443 9.04455748270995e-10 -1.04311294572608 4.3896749999504e-25 mirMAP -0.188122997757206 0.00844970036487827 NA NA NA hsa-miR-19a-3p FZD3 0.722913586880779 2.76301458932381e-10 -1.04311294572608 4.3896749999504e-25 mirMAP -0.170280111877158 0.00085062903755598 NA NA NA hsa-miR-20a-5p FZD3 0.702602695798242 4.06372887613329e-13 -1.04311294572608 4.3896749999504e-25 MirTarget;mirMAP;miRNATAP -0.26614537443907 7.83474342254034e-06 NA NA NA hsa-miR-2355-3p FZD3 1.32757890426926 1.88016636795886e-18 -1.04311294572608 4.3896749999504e-25 mirMAP -0.145058213321557 0.00015535039636979 NA NA NA hsa-miR-23a-3p FZD3 0.761438723382355 4.09310879199257e-27 -1.04311294572608 4.3896749999504e-25 MirTarget -0.40556276482203 2.09127965855521e-07 NA NA NA hsa-miR-27a-3p FZD3 0.558934437526245 1.44256383086177e-12 -1.04311294572608 4.3896749999504e-25 miRNATAP -0.36071915288459 8.69667689642873e-07 NA NA NA hsa-miR-28-3p FZD3 1.01277915413238 1.8655970171461e-43 -1.04311294572608 4.3896749999504e-25 mirMAP -0.512278374058261 2.15217696855893e-13 NA NA NA hsa-miR-330-3p FZD3 0.912906550436308 3.35037014057665e-13 -1.04311294572608 4.3896749999504e-25 MirTarget;PITA;miRNATAP -0.176244411509209 0.0001775833510189 NA NA NA hsa-miR-338-3p FZD3 0.906250377628867 2.76970900371139e-15 -1.04311294572608 4.3896749999504e-25 PITA;miRanda -0.230562538359162 3.52727172858029e-06 NA NA NA hsa-miR-338-5p FZD3 0.628429807914222 1.27575140717947e-06 -1.04311294572608 4.3896749999504e-25 mirMAP -0.193416367939392 2.81863006033106e-05 NA NA NA hsa-miR-342-3p FZD3 1.4124432570595 1.07208971556131e-28 -1.04311294572608 4.3896749999504e-25 miRanda -0.213548558134392 5.83889280548379e-07 NA NA NA hsa-miR-374a-3p FZD3 1.13863935833993 2.79089304015401e-44 -1.04311294572608 4.3896749999504e-25 mirMAP -0.533949837747404 3.21209352596017e-18 NA NA NA hsa-miR-374a-5p FZD3 0.543061152108237 2.19403097299769e-14 -1.04311294572608 4.3896749999504e-25 mirMAP -0.518813184476156 9.44766833815146e-11 NA NA NA hsa-miR-374b-5p FZD3 0.0804104684417872 0.365593963035077 -1.04311294572608 4.3896749999504e-25 mirMAP -0.187522547562267 0.00604836097855249 NA NA NA hsa-miR-452-3p FZD3 1.72039996672257 1.35748079442153e-22 -1.04311294572608 4.3896749999504e-25 MirTarget -0.158706998343871 7.72548940529983e-07 NA NA NA hsa-miR-452-5p FZD3 2.05325688842141 2.82238393643084e-40 -1.04311294572608 4.3896749999504e-25 mirMAP -0.247182958968441 6.96496325447191e-14 NA NA NA hsa-miR-454-3p FZD3 0.68285296887698 1.17407812677787e-08 -1.04311294572608 4.3896749999504e-25 mirMAP -0.128805658384015 0.00889687462362434 NA NA NA hsa-miR-590-3p FZD3 1.13702599385212 3.53435739887793e-22 -1.04311294572608 4.3896749999504e-25 miRanda;mirMAP;miRNATAP -0.22571834463035 1.99847968139135e-06 NA NA NA hsa-miR-625-3p FZD3 1.09679549288964 4.60800634006165e-20 -1.04311294572608 4.3896749999504e-25 mirMAP -0.169603485564342 0.000328022052507216 NA NA NA hsa-miR-629-5p FZD3 1.73389921851483 5.39614356468007e-48 -1.04311294572608 4.3896749999504e-25 MirTarget -0.28509682096437 1.43667036293409e-11 NA NA NA hsa-miR-7-1-3p FZD3 0.544601828025304 5.33830451326047e-07 -1.04311294572608 4.3896749999504e-25 mirMAP -0.1474047023299 0.00697865454508537 NA NA NA hsa-miR-93-5p FZD3 1.37365940377595 2.37567548683245e-46 -1.04311294572608 4.3896749999504e-25 MirTarget;mirMAP;miRNATAP -0.39312109889616 5.716812231823e-14 NA NA NA hsa-miR-10a-5p FZD4 -1.17164272592931 4.86621098042279e-24 0.458457429096661 1.45681215340493e-05 MirTarget -0.135574203047511 0.00424899578871124 NA NA NA hsa-miR-125b-5p FZD4 -0.825456421494266 2.13029877878434e-15 0.458457429096661 1.45681215340493e-05 miRNAWalker2_validate -0.144600660127576 0.00796821817804433 NA NA NA hsa-miR-132-3p FZD4 0.291409674711894 0.000912684337101876 0.458457429096661 1.45681215340493e-05 mirMAP -0.313066475215544 2.58848789609525e-06 NA NA NA hsa-miR-199b-5p FZD4 -2.39483476763681 1.04659509514884e-17 0.458457429096661 1.45681215340493e-05 MirTarget;PITA;miRanda;miRNATAP -0.105604879579982 1.60106567131654e-07 NA NA NA hsa-miR-200b-3p FZD4 -1.70383252137161 2.38979336321755e-30 0.458457429096661 1.45681215340493e-05 mirMAP -0.111830163416284 0.00190816196717208 NA NA NA hsa-miR-212-3p FZD4 0.140490094813501 0.298248972687012 0.458457429096661 1.45681215340493e-05 mirMAP -0.139553058446201 0.00155018292855188 NA NA NA hsa-miR-22-5p FZD4 -0.197038086012602 0.106234828461117 0.458457429096661 1.45681215340493e-05 mirMAP -0.187016958866808 0.000106227572900588 NA NA NA hsa-miR-589-3p FZD4 -0.0184909376114044 0.903149951095234 0.458457429096661 1.45681215340493e-05 mirMAP -0.140960018589024 0.000362867225129375 NA NA NA hsa-miR-92b-3p FZD4 0.418630595140165 6.50466149211154e-05 0.458457429096661 1.45681215340493e-05 mirMAP -0.201633069493349 0.000301326558594845 NA NA NA hsa-miR-149-5p FZD5 -1.95790336710741 8.46371715052367e-27 0.583650554484417 1.47306695584846e-06 miRNAWalker2_validate;miRNATAP -0.195535517950565 5.59711687641786e-09 NA NA NA hsa-miR-335-3p FZD5 -1.36498175550207 6.84287752180534e-13 0.583650554484417 1.47306695584846e-06 MirTarget;mirMAP -0.154808826706275 5.71962463751601e-06 NA NA NA hsa-let-7a-3p FZD6 0.0677487960013088 0.460458477653989 -0.713547911934427 4.6402947278289e-14 MirTarget;mirMAP -0.218394082029521 0.000241194213279582 NA NA NA hsa-let-7f-1-3p FZD6 0.477913872379336 4.46669616865068e-05 -0.713547911934427 4.6402947278289e-14 MirTarget;mirMAP -0.203755820988442 3.90477399842581e-05 NA NA NA hsa-miR-101-3p FZD6 0.683973909682285 2.88573524246948e-15 -0.713547911934427 4.6402947278289e-14 miRNAWalker2_validate;MirTarget -0.492555382183418 1.12231291794818e-17 NA NA NA hsa-miR-107 FZD6 0.140046250553248 0.0943611632552367 -0.713547911934427 4.6402947278289e-14 miRanda -0.366761211433128 1.18353924890157e-08 NA NA NA hsa-miR-126-5p FZD6 0.785607261431085 5.77058629454465e-13 -0.713547911934427 4.6402947278289e-14 mirMAP;miRNATAP -0.16688559425803 0.000513078757809893 NA NA NA hsa-miR-130b-3p FZD6 1.12788913578446 2.939369462276e-16 -0.713547911934427 4.6402947278289e-14 MirTarget -0.127564853523286 0.000674035276870961 NA NA NA hsa-miR-140-5p FZD6 0.504309496243674 3.09884038729031e-11 -0.713547911934427 4.6402947278289e-14 MirTarget;miRanda -0.181823097770399 0.00966291980828589 NA NA NA hsa-miR-144-3p FZD6 1.4617706700291 9.18139413836375e-11 -0.713547911934427 4.6402947278289e-14 MirTarget -0.105585982487327 5.0418483078103e-06 NA NA NA hsa-miR-194-5p FZD6 0.62222617402691 0.00659826803316099 -0.713547911934427 4.6402947278289e-14 MirTarget -0.196314924199211 1.75605555280948e-18 NA NA NA hsa-miR-19a-3p FZD6 0.722913586880779 2.76301458932381e-10 -0.713547911934427 4.6402947278289e-14 MirTarget -0.143881568742793 0.00184229786276554 NA NA NA hsa-miR-342-3p FZD6 1.4124432570595 1.07208971556131e-28 -0.713547911934427 4.6402947278289e-14 miRanda -0.198359086540678 2.75262859196131e-07 NA NA NA hsa-miR-455-5p FZD6 0.773674551205946 2.12957541541474e-09 -0.713547911934427 4.6402947278289e-14 miRanda -0.303740205385634 1.47557989051135e-14 NA NA NA hsa-miR-590-3p FZD6 1.13702599385212 3.53435739887793e-22 -0.713547911934427 4.6402947278289e-14 MirTarget;PITA;miRanda;mirMAP -0.173708996665933 5.64760519619443e-05 NA NA NA hsa-miR-590-5p FZD6 0.709763558412506 1.11883921359361e-11 -0.713547911934427 4.6402947278289e-14 PITA;miRanda -0.175146230138535 0.000505674605027954 NA NA NA hsa-miR-106b-5p FZD7 1.07509411417907 2.11739194181878e-36 -1.04844010704488 5.51861670571538e-18 miRNATAP -0.499535768578559 4.41278638982439e-12 NA NA NA hsa-miR-130b-5p FZD7 0.92990617673277 3.75880436852717e-12 -1.04844010704488 5.51861670571538e-18 mirMAP -0.185021595310988 0.000273467933484435 NA NA NA hsa-miR-142-3p FZD7 1.88928758773299 2.72985643829893e-22 -1.04844010704488 5.51861670571538e-18 miRanda -0.130459044700555 0.000107194209018149 25976503 MicroRNA 142 3p inhibits cell proliferation and invasion of cervical cancer cells by targeting FZD7; In addition we demonstrated that FZD7 was a direct target of miR-142-3p by dual luciferase assay and Western blot analysis; Overexpression of FZD7 expression was able to reverse the inhibitory effects induced by miR-142-3p cervical and endocervical cancer hsa-miR-142-5p FZD7 1.88417391525707 1.2096808039882e-27 -1.04844010704488 5.51861670571538e-18 MirTarget;PITA;miRNATAP -0.179999492386373 1.14904045606403e-06 25976503 MicroRNA 142 3p inhibits cell proliferation and invasion of cervical cancer cells by targeting FZD7 cervical and endocervical cancer hsa-miR-186-5p FZD7 0.507217561043443 9.04455748270995e-10 -1.04844010704488 5.51861670571538e-18 mirMAP -0.351888110196916 2.3860888672338e-05 NA NA NA hsa-miR-20a-5p FZD7 0.702602695798242 4.06372887613329e-13 -1.04844010704488 5.51861670571538e-18 miRNATAP -0.324563062850531 3.4537039190343e-06 NA NA NA hsa-miR-2355-5p FZD7 1.57515081110162 3.54962327490702e-48 -1.04844010704488 5.51861670571538e-18 MirTarget -0.304454010614901 3.91408050938596e-08 NA NA NA hsa-miR-27a-3p FZD7 0.558934437526245 1.44256383086177e-12 -1.04844010704488 5.51861670571538e-18 MirTarget;miRNATAP -0.227411027336672 0.00924773653023277 24018051 Moreover up-regulation of miR-27a did not decrease the FZD7 mRNA level but significantly reduce its protein expression in BEL/5-FU cells; It was also confirmed that reduction of FZD7 by RNA interference induced inhibitory effects on the expression of MDR1/P-glycoprotein and β-catenin similar to miR-27a liver cancer hsa-miR-330-3p FZD7 0.912906550436308 3.35037014057665e-13 -1.04844010704488 5.51861670571538e-18 mirMAP -0.308419059049457 1.53866733934032e-08 NA NA NA hsa-miR-486-5p FZD7 1.16748143760361 1.68410465883829e-08 -1.04844010704488 5.51861670571538e-18 miRanda -0.101124145271838 0.00239209711612664 NA NA NA hsa-miR-590-3p FZD7 1.13702599385212 3.53435739887793e-22 -1.04844010704488 5.51861670571538e-18 miRanda -0.259592153900114 3.37650758938895e-06 NA NA NA hsa-miR-616-5p FZD7 0.913426384742148 3.78418389333709e-09 -1.04844010704488 5.51861670571538e-18 mirMAP -0.157498116643287 0.000476353438254426 NA NA NA hsa-let-7e-5p GDF6 -0.727009689927955 1.30690859412163e-11 3.7870508247201 4.98424921450452e-35 MirTarget;miRNATAP -0.527735030276111 0.00202013868771548 NA NA NA hsa-let-7g-5p GDF6 -0.739744008507763 1.07979566264383e-14 3.7870508247201 4.98424921450452e-35 MirTarget;miRNATAP -1.05049046718614 1.96472615303638e-08 NA NA NA hsa-miR-136-5p GDF6 -1.67696564080585 1.99625416234538e-18 3.7870508247201 4.98424921450452e-35 miRNATAP -0.494298410948741 7.75797922976636e-08 NA NA NA hsa-miR-141-3p GDF6 -5.87110686537457 1.20877726722907e-85 3.7870508247201 4.98424921450452e-35 TargetScan -0.574014404952014 6.53657485349344e-41 NA NA NA hsa-miR-200b-3p GDF6 -1.70383252137161 2.38979336321755e-30 3.7870508247201 4.98424921450452e-35 TargetScan -0.879274913053141 2.1993260687206e-15 NA NA NA hsa-miR-379-5p GDF6 -0.844571840578256 4.56275837943769e-06 3.7870508247201 4.98424921450452e-35 MirTarget -0.293432156136155 0.0036984310078916 NA NA NA hsa-miR-429 GDF6 -2.16569233119434 2.66862243626443e-37 3.7870508247201 4.98424921450452e-35 PITA;miRanda;miRNATAP -0.680026958791692 1.33324624191855e-12 NA NA NA hsa-miR-493-5p GDF6 -1.03936667688502 3.71842205277243e-08 3.7870508247201 4.98424921450452e-35 miRNATAP -0.425718168102363 2.27147993522901e-05 NA NA NA hsa-miR-532-3p GDF6 -1.759223962964 7.9077916669414e-40 3.7870508247201 4.98424921450452e-35 PITA;miRNATAP -0.953783212911198 2.16877053505994e-15 NA NA NA hsa-miR-589-3p GDF6 -0.0184909376114044 0.903149951095234 3.7870508247201 4.98424921450452e-35 MirTarget -0.332851505582658 0.00891237935500048 NA NA NA hsa-miR-197-3p GDF7 0.297760714271229 0.00102679606305048 -2.051601383087 2.18453120455222e-22 miRNAWalker2_validate -0.499654176705736 0.000269415867574162 NA NA NA hsa-miR-7-1-3p GDF7 0.544601828025304 5.33830451326047e-07 -2.051601383087 2.18453120455222e-22 mirMAP -0.410973812809145 0.000270863591170261 NA NA NA hsa-miR-141-3p GLI2 -5.87110686537457 1.20877726722907e-85 0.730385107816031 6.90083826406878e-06 MirTarget -0.10513323253185 5.45812090108564e-06 NA NA NA hsa-miR-182-5p GLI2 -0.608710746044567 0.0025264935278104 0.730385107816031 6.90083826406878e-06 MirTarget -0.128802982015977 0.00401555220572714 NA NA NA hsa-miR-200a-3p GLI2 -1.43409013664263 2.00188483717828e-20 0.730385107816031 6.90083826406878e-06 MirTarget -0.316798754073367 4.54530722478242e-09 NA NA NA hsa-miR-30a-5p GLI2 -0.778411951775343 2.73322451127932e-16 0.730385107816031 6.90083826406878e-06 MirTarget -0.503348111291882 2.20179446177043e-08 NA NA NA hsa-miR-30b-5p GLI2 -1.18330589477119 6.8341618466966e-27 0.730385107816031 6.90083826406878e-06 MirTarget -0.353015484735422 2.72373233040355e-06 NA NA NA hsa-miR-30c-5p GLI2 -1.08783070774238 2.02505402525786e-24 0.730385107816031 6.90083826406878e-06 MirTarget -0.453805546860877 5.24270339879165e-09 NA NA NA hsa-miR-30d-5p GLI2 -0.202727675788184 0.00659067084745794 0.730385107816031 6.90083826406878e-06 MirTarget -0.557477650678544 4.7010628697309e-06 NA NA NA hsa-miR-30e-5p GLI2 -0.0905907245198101 0.21196704484334 0.730385107816031 6.90083826406878e-06 MirTarget -1.06062386022226 1.5157818316762e-18 NA NA NA hsa-miR-3607-3p GLI2 -0.529788328085356 0.00511771034738625 0.730385107816031 6.90083826406878e-06 miRNATAP -0.246763975104364 1.56200795030021e-07 NA NA NA hsa-miR-501-3p GLI2 -1.30538668412879 3.52127864608017e-18 0.730385107816031 6.90083826406878e-06 MirTarget;miRNATAP -0.267207679847198 2.52062299752704e-06 NA NA NA hsa-miR-502-3p GLI2 -1.10416310320528 1.55354569985732e-22 0.730385107816031 6.90083826406878e-06 MirTarget;miRNATAP -0.462335119239096 3.04305179638984e-10 NA NA NA hsa-miR-577 GLI2 -1.48881999472397 7.03080165111147e-10 0.730385107816031 6.90083826406878e-06 MirTarget -0.171990397835202 2.22357866216975e-06 NA NA NA hsa-miR-664a-3p GLI2 -0.019312777079624 0.825861598748857 0.730385107816031 6.90083826406878e-06 MirTarget -0.421301377978583 5.06164989052846e-05 NA NA NA hsa-miR-181a-5p GSK3B 1.11111114875339 3.97880443756442e-29 -0.228723498264944 0.000365732006378195 mirMAP -0.111663336693774 0.0006569391284283 NA NA NA hsa-miR-181b-5p GSK3B 1.49054296272357 3.69051660739368e-41 -0.228723498264944 0.000365732006378195 mirMAP -0.112111617296075 6.37240999540997e-05 NA NA NA hsa-miR-18a-5p GSK3B 0.936704393213466 1.05064580570579e-10 -0.228723498264944 0.000365732006378195 miRNATAP -0.129655229012053 2.96928927454631e-08 NA NA NA hsa-miR-19a-3p GSK3B 0.722913586880779 2.76301458932381e-10 -0.228723498264944 0.000365732006378195 mirMAP -0.128885925042799 1.75451278817822e-05 NA NA NA hsa-miR-19b-3p GSK3B 0.195940928879427 0.0300512922542325 -0.228723498264944 0.000365732006378195 mirMAP -0.147506705421778 0.000182148718420472 NA NA NA hsa-miR-26b-5p GSK3B -0.251437253429904 0.00270935785098697 -0.228723498264944 0.000365732006378195 miRNATAP -0.153051347819886 0.000309841684251065 NA NA NA hsa-miR-27a-3p GSK3B 0.558934437526245 1.44256383086177e-12 -0.228723498264944 0.000365732006378195 miRNATAP -0.194470247735897 7.8023921113285e-06 NA NA NA hsa-miR-590-3p GSK3B 1.13702599385212 3.53435739887793e-22 -0.228723498264944 0.000365732006378195 miRanda;miRNATAP -0.108155182029881 0.000128807781068845 NA NA NA hsa-miR-16-2-3p ID1 1.3046118743965 4.17207934608428e-19 -0.89293542859543 3.16189066833414e-10 MirTarget -0.144077865349576 0.00567173307418396 NA NA NA hsa-miR-215-5p ID1 1.57223951497888 6.18833867819653e-10 -0.89293542859543 3.16189066833414e-10 miRNAWalker2_validate -0.100484766546532 0.00108972036422194 NA NA NA hsa-miR-29b-3p ID1 -0.228125979913806 0.0271621721891603 -0.89293542859543 3.16189066833414e-10 MirTarget -0.272580826263605 0.000476612915587695 22249264;24662327 Incubation of lung cancer cells with the Src inhibitor saracatinib led to the upregulation of several miRNAs including miR-29b which was the most highly upregulated miRNA with predicted binding to the ID1 3'-untranslated region UTR; Luciferase reporter assays confirmed direct binding of miR-29b to the ID1 3'-UTR; Expression of miR-29b suppressed ID1 levels and significantly reduced migration and invasion;Id 1 a protein repressed by miR 29b facilitates the TGFβ1 induced epithelial mesenchymal transition in human ovarian cancer cells ; lung cancer;ovarian cancer hsa-miR-29c-3p ID1 -0.238671318446745 0.0141475322347596 -0.89293542859543 3.16189066833414e-10 MirTarget -0.214616810560722 0.00989670647295927 NA NA NA hsa-miR-330-3p ID1 0.912906550436308 3.35037014057665e-13 -0.89293542859543 3.16189066833414e-10 PITA -0.186581210321571 0.00319257638935859 NA NA NA hsa-miR-330-5p ID1 1.44960468659754 2.12131210588035e-45 -0.89293542859543 3.16189066833414e-10 miRNATAP -0.311220910540193 4.23227965779348e-06 NA NA NA hsa-miR-331-3p ID1 0.431607034018882 6.83022920590941e-05 -0.89293542859543 3.16189066833414e-10 MirTarget -0.197200306310818 0.00764877599865157 NA NA NA hsa-miR-200c-3p ID2 -5.40303134829523 2.74173143360645e-94 0.445337795024294 1.58113421282299e-06 miRNATAP -0.100566283563312 2.45882912723149e-12 NA NA NA hsa-miR-27b-3p ID2 -0.699527231242518 1.07356023759234e-15 0.445337795024294 1.58113421282299e-06 MirTarget;miRNATAP -0.16167700894291 0.00475411741852718 NA NA NA hsa-miR-125a-5p ITGB2 -0.561874059994802 7.3931856356891e-13 2.55954185412635 1.03165457547765e-51 miRanda -1.20351549159701 9.90377482777656e-21 NA NA NA hsa-miR-335-5p ITGB2 -2.09515619961552 1.03765771499548e-25 2.55954185412635 1.03165457547765e-51 miRNAWalker2_validate -0.274345950759218 5.28837219539329e-08 NA NA NA hsa-miR-429 ITGB2 -2.16569233119434 2.66862243626443e-37 2.55954185412635 1.03165457547765e-51 miRanda -0.45822077994145 7.60483601708919e-17 NA NA NA hsa-let-7a-3p LATS1 0.0677487960013088 0.460458477653989 -0.719631510725911 4.94074967159677e-08 MirTarget;mirMAP -0.33187896334049 4.34534606106708e-05 NA NA NA hsa-let-7f-1-3p LATS1 0.477913872379336 4.46669616865068e-05 -0.719631510725911 4.94074967159677e-08 MirTarget;mirMAP -0.210365408859685 0.00202584282121985 NA NA NA hsa-miR-103a-3p LATS1 0.779373475434461 7.37867196796994e-20 -0.719631510725911 4.94074967159677e-08 miRNAWalker2_validate;MirTarget -0.299973390845447 0.000264685932506441 NA NA NA hsa-miR-107 LATS1 0.140046250553248 0.0943611632552367 -0.719631510725911 4.94074967159677e-08 MirTarget;miRanda;miRNATAP -0.24159654209784 0.00708093006610884 NA NA NA hsa-miR-15a-5p LATS1 1.42663930007845 1.36006952074963e-57 -0.719631510725911 4.94074967159677e-08 MirTarget;miRNATAP -0.389891820978107 1.33598008169046e-08 NA NA NA hsa-miR-15b-5p LATS1 0.773001494057531 1.71784656078957e-16 -0.719631510725911 4.94074967159677e-08 MirTarget;miRNATAP -0.266204171263365 0.000434080678033411 NA NA NA hsa-miR-16-2-3p LATS1 1.3046118743965 4.17207934608428e-19 -0.719631510725911 4.94074967159677e-08 mirMAP -0.213578637231889 7.21189222398566e-06 NA NA NA hsa-miR-16-5p LATS1 0.934012514027655 4.85417898318515e-24 -0.719631510725911 4.94074967159677e-08 miRNAWalker2_validate;MirTarget;miRNATAP -0.23082289371231 0.00211552420485983 NA NA NA hsa-miR-181a-5p LATS1 1.11111114875339 3.97880443756442e-29 -0.719631510725911 4.94074967159677e-08 MirTarget;miRNATAP -0.237380131168953 0.000532457021397273 NA NA NA hsa-miR-181b-5p LATS1 1.49054296272357 3.69051660739368e-41 -0.719631510725911 4.94074967159677e-08 MirTarget;miRNATAP -0.275275037152698 2.39749805234575e-06 NA NA NA hsa-miR-193a-3p LATS1 0.849206638484406 3.68101781083335e-14 -0.719631510725911 4.94074967159677e-08 miRanda -0.364820126294694 5.83131432279732e-09 NA NA NA hsa-miR-195-5p LATS1 0.346502644882604 0.0092562828415903 -0.719631510725911 4.94074967159677e-08 MirTarget;miRNATAP -0.16984670708081 0.00227899500691016 NA NA NA hsa-miR-21-5p LATS1 2.51462371613332 3.30620591950316e-66 -0.719631510725911 4.94074967159677e-08 miRNAWalker2_validate -0.2459452812996 1.13021371130976e-09 25769949 miR 21 modulates resistance of HR HPV positive cervical cancer cells to radiation through targeting LATS1; By using dual luciferase assay we verified a binding site between miR-21 and 3'-UTR of large tumor suppressor kinase 1 LATS1; Through direct binding miR-21 can regulate LATS1 expression in cervical cancer cells; LATS1 overexpression can reverse miR-21 induced higher colony formation rate and also reduced miR-21 induced S phase accumulation and G2/M phase block reduction under radiation treatment drug resistance cervical and endocervical cancer hsa-miR-25-3p LATS1 1.12016166564779 3.79069348635778e-48 -0.719631510725911 4.94074967159677e-08 miRNATAP -0.231349384032695 0.00581981308079605 NA NA NA hsa-miR-32-5p LATS1 0.407826130035097 7.26884631998646e-06 -0.719631510725911 4.94074967159677e-08 miRNATAP -0.245763254218961 0.00247585510871427 NA NA NA hsa-miR-330-3p LATS1 0.912906550436308 3.35037014057665e-13 -0.719631510725911 4.94074967159677e-08 MirTarget;PITA -0.178794075442723 0.00218267513226079 NA NA NA hsa-miR-361-5p LATS1 0.0514169367202078 0.382929376393199 -0.719631510725911 4.94074967159677e-08 mirMAP -0.35184775864451 0.0066144142569879 NA NA NA hsa-miR-497-5p LATS1 0.227757383708836 0.0600073987853074 -0.719631510725911 4.94074967159677e-08 MirTarget;miRNATAP -0.15940143468856 0.00960206932748976 NA NA NA hsa-miR-590-3p LATS1 1.13702599385212 3.53435739887793e-22 -0.719631510725911 4.94074967159677e-08 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.238976803115605 5.11742232923466e-05 NA NA NA hsa-miR-590-5p LATS1 0.709763558412506 1.11883921359361e-11 -0.719631510725911 4.94074967159677e-08 miRanda;miRNATAP -0.281517236906773 4.11783690763154e-05 NA NA NA hsa-miR-616-5p LATS1 0.913426384742148 3.78418389333709e-09 -0.719631510725911 4.94074967159677e-08 MirTarget;miRNATAP -0.127079307535848 0.00760036778358038 NA NA NA hsa-miR-92b-3p LATS1 0.418630595140165 6.50466149211154e-05 -0.719631510725911 4.94074967159677e-08 miRNATAP -0.214583883198393 0.00231990133969456 NA NA NA hsa-miR-103a-3p LATS2 0.779373475434461 7.37867196796994e-20 -0.107812256070195 0.11143612027285 miRNATAP -0.112793058398058 0.0064126133760194 27602163 Furthermore miR-103 repressed large tumor suppressor kinase 2 LATS2 expression by directly binding to the LATS2-3'-untranslated region and an inverse correlation was identified between the expression of miR-103 and LATS2 messenger RNA in primary CRC tissues; In summary miR-103 performs a critical role in the promotion of the invasive and metastatic capacities of CRC possibly by directly targeting LATS2 colorectal cancer hsa-miR-590-3p LATS2 1.13702599385212 3.53435739887793e-22 -0.107812256070195 0.11143612027285 PITA;miRanda -0.102228846764395 0.000566700086498702 NA NA NA hsa-miR-107 LEF1 0.140046250553248 0.0943611632552367 0.418404112804963 0.0253732275048255 miRanda -0.350799889230692 0.00496598986390596 NA NA NA hsa-miR-3065-3p LEF1 -1.64500070417457 9.57561660036697e-16 0.418404112804963 0.0253732275048255 miRNATAP -0.295694386150053 3.16655103786743e-10 NA NA NA hsa-miR-455-5p LEF1 0.773674551205946 2.12957541541474e-09 0.418404112804963 0.0253732275048255 miRanda -0.435515986434238 1.42370060375117e-08 NA NA NA hsa-miR-501-5p LEF1 -1.1103073934745 1.81589804886553e-16 0.418404112804963 0.0253732275048255 PITA;miRNATAP -0.261357099364367 0.00033612990039779 NA NA NA hsa-miR-24-3p LIMD1 0.173813044685099 0.00565259443420961 0.116445615876376 0.0590342669295383 miRNAWalker2_validate;MirTarget -0.147232752003565 0.00736418801573165 NA NA NA hsa-miR-142-3p LLGL2 1.88928758773299 2.72985643829893e-22 -1.51592030741108 2.44415341908816e-30 PITA;miRanda;miRNATAP -0.349186226379715 4.15605553442283e-22 NA NA NA hsa-miR-146b-3p LLGL2 1.20941495066078 2.12939149602665e-10 -1.51592030741108 2.44415341908816e-30 miRNATAP -0.323745234621537 1.30560379190428e-16 NA NA NA hsa-miR-339-5p LLGL2 0.322848334531193 0.0117281778821612 -1.51592030741108 2.44415341908816e-30 miRanda -0.237728397624834 0.000138003722545946 NA NA NA hsa-miR-423-5p LLGL2 0.250929012519631 0.00288495915028486 -1.51592030741108 2.44415341908816e-30 miRNATAP -0.403374655570815 2.26199067942876e-05 NA NA NA hsa-miR-126-5p MPP5 0.785607261431085 5.77058629454465e-13 -1.48244781064327 1.02322561680438e-49 mirMAP -0.215151456555115 0.00015933651854402 NA NA NA hsa-miR-130b-3p MPP5 1.12788913578446 2.939369462276e-16 -1.48244781064327 1.02322561680438e-49 miRNAWalker2_validate -0.426561847859488 9.90495004584379e-25 NA NA NA hsa-miR-140-3p MPP5 0.989350547007025 6.14964028267239e-25 -1.48244781064327 1.02322561680438e-49 PITA -0.467900183485416 7.53785144517887e-15 NA NA NA hsa-miR-140-5p MPP5 0.504309496243674 3.09884038729031e-11 -1.48244781064327 1.02322561680438e-49 miRanda -0.427835921738335 1.93016625652119e-07 NA NA NA hsa-miR-142-3p MPP5 1.88928758773299 2.72985643829893e-22 -1.48244781064327 1.02322561680438e-49 miRanda -0.246375638303551 7.04782773006154e-17 NA NA NA hsa-miR-148b-3p MPP5 0.346011252093377 4.27203463315056e-06 -1.48244781064327 1.02322561680438e-49 MirTarget -0.235388358088709 0.00602260875260908 NA NA NA hsa-miR-155-5p MPP5 3.26274490570809 5.06841441826518e-51 -1.48244781064327 1.02322561680438e-49 miRNAWalker2_validate;MirTarget -0.313510650580105 1.2485275930158e-46 NA NA NA hsa-miR-16-2-3p MPP5 1.3046118743965 4.17207934608428e-19 -1.48244781064327 1.02322561680438e-49 MirTarget -0.343946510620888 4.14998488532032e-18 NA NA NA hsa-miR-181a-5p MPP5 1.11111114875339 3.97880443756442e-29 -1.48244781064327 1.02322561680438e-49 MirTarget -0.49394701844866 3.0293987178639e-18 NA NA NA hsa-miR-181b-5p MPP5 1.49054296272357 3.69051660739368e-41 -1.48244781064327 1.02322561680438e-49 MirTarget -0.493745185338117 2.88556234398806e-25 NA NA NA hsa-miR-181c-5p MPP5 0.762784646696248 4.48373118147729e-10 -1.48244781064327 1.02322561680438e-49 MirTarget -0.25501768542231 5.10623647113536e-07 NA NA NA hsa-miR-181d-5p MPP5 1.00720380524132 6.04219503683814e-14 -1.48244781064327 1.02322561680438e-49 MirTarget -0.314930346456232 2.10002415497791e-12 NA NA NA hsa-miR-195-3p MPP5 0.808592887366705 6.8151241038711e-09 -1.48244781064327 1.02322561680438e-49 MirTarget -0.161491580304459 0.000375529340397101 NA NA NA hsa-miR-21-5p MPP5 2.51462371613332 3.30620591950316e-66 -1.48244781064327 1.02322561680438e-49 miRNAWalker2_validate -0.473988477863191 1.38906458432619e-55 NA NA NA hsa-miR-223-3p MPP5 1.23291409735619 1.07767240442694e-17 -1.48244781064327 1.02322561680438e-49 MirTarget -0.392243284939816 6.1295901609204e-23 NA NA NA hsa-miR-23a-3p MPP5 0.761438723382355 4.09310879199257e-27 -1.48244781064327 1.02322561680438e-49 MirTarget -0.774732505947112 2.71010875772739e-22 NA NA NA hsa-miR-320a MPP5 0.412740558379182 2.02929519701706e-05 -1.48244781064327 1.02322561680438e-49 miRanda -0.378237389341338 5.8225102300132e-09 NA NA NA hsa-miR-320b MPP5 0.300497419754843 0.0245219177384172 -1.48244781064327 1.02322561680438e-49 miRanda -0.223368826650116 2.92064658399234e-06 NA NA NA hsa-miR-330-5p MPP5 1.44960468659754 2.12131210588035e-45 -1.48244781064327 1.02322561680438e-49 PITA;miRanda -0.573551016543854 1.52426198477009e-30 NA NA NA hsa-miR-338-3p MPP5 0.906250377628867 2.76970900371139e-15 -1.48244781064327 1.02322561680438e-49 miRanda -0.244044899908217 4.9168735973396e-06 NA NA NA hsa-miR-425-5p MPP5 0.146116356753256 0.318699399094984 -1.48244781064327 1.02322561680438e-49 MirTarget -0.127841443331924 0.00374853620838463 NA NA NA hsa-miR-542-3p MPP5 0.431147917094433 0.000254981247606435 -1.48244781064327 1.02322561680438e-49 miRanda -0.176041020770043 0.00120003808198973 NA NA NA hsa-miR-576-5p MPP5 1.06681109513983 5.69294424466526e-24 -1.48244781064327 1.02322561680438e-49 PITA -0.439056101569496 8.37575173007907e-16 NA NA NA hsa-miR-590-3p MPP5 1.13702599385212 3.53435739887793e-22 -1.48244781064327 1.02322561680438e-49 MirTarget;PITA;miRanda;miRNATAP -0.423947865255042 5.30569282314513e-18 NA NA NA hsa-miR-590-5p MPP5 0.709763558412506 1.11883921359361e-11 -1.48244781064327 1.02322561680438e-49 miRanda -0.390535939611872 2.20498795555623e-11 NA NA NA hsa-miR-616-5p MPP5 0.913426384742148 3.78418389333709e-09 -1.48244781064327 1.02322561680438e-49 MirTarget -0.140937774075534 0.000623701863254165 NA NA NA hsa-miR-93-3p MPP5 0.379664250785728 9.76327751780657e-05 -1.48244781064327 1.02322561680438e-49 miRNAWalker2_validate -0.235261100343208 0.000347348551426827 NA NA NA hsa-let-7g-5p MYC -0.739744008507763 1.07979566264383e-14 1.69954133129988 7.75526107259408e-27 miRNAWalker2_validate;miRTarBase -0.398905767136213 2.71236287032834e-05 NA NA NA hsa-miR-135a-5p MYC -2.13422485001223 6.29449029671498e-14 1.69954133129988 7.75526107259408e-27 miRNAWalker2_validate -0.108827259333515 0.000903589484065675 23176581 Moreover based on the results of this analysis we investigated whether miR-135a targeted the c-MYC gene in RCC; Gain-of-function and luciferase reporter assays showed that c-MYC was directly regulated by miR-135a in RCC cells kidney renal cell cancer hsa-miR-335-5p MYC -2.09515619961552 1.03765771499548e-25 1.69954133129988 7.75526107259408e-27 miRNAWalker2_validate -0.216426299788151 7.62566723121896e-07 NA NA NA hsa-miR-429 MYC -2.16569233119434 2.66862243626443e-37 1.69954133129988 7.75526107259408e-27 miRNAWalker2_validate -0.389721783902253 2.72292816859272e-16 21684154;24633485 miR 429 modulates the expression of c myc in human gastric carcinoma cells; SGC-7901 gastric cancer cells were transfected with miR-429 mimics and endogenous c-myc expression was detected by western blots; We performed functional assays using the 3'UTR of the c-myc gene as a miR-429 target in a luciferase reporter assay system; miR-429 significantly downregulated endogenous c-myc expression in SGC-7901 cells; Action of miR/429 on c-myc 3'UTR was confirmed; c-myc is an important miR-429 target gene;It is known that miR-429 is down-regulated and functions as a tumor suppressor by targeting c-myc and PLGG1 in gastric and breast cancer ; gastric cancer;sarcoma hsa-miR-744-5p MYC -0.348985243196771 0.000187889982228835 1.69954133129988 7.75526107259408e-27 miRNAWalker2_validate -0.377458526504721 0.000190443255959769 24991193 Decrease expression of microRNA 744 promotes cell proliferation by targeting c Myc in human hepatocellular carcinoma; Quantitative reverse-transcription polymerase chain reaction qRT-PCR was conducted to detect the expression of miR-744 and Immunohistochemistry was performed to detect expression of c-Myc in HCC specimens and adjacent normal tissues; Luciferase reporter assays was performed to confirm whether miR-744 regulated the expression of c-Myc; Luciferase assay and Western blot analysis revealed that c-Myc is a direct target of miR-744; Down-regulation of miR-744 and up-regulation of c-Myc were detected in HCC specimens compared with adjacent normal tissues; Moreover restoration of miR-744 rescues c-Myc induced HCC proliferation; Our data suggest that miR-744 exerts its tumor suppressor function by targeting c-Myc leading to the inhibition of HCC cell growth liver cancer hsa-miR-132-3p NF2 0.291409674711894 0.000912684337101876 -0.27390922602413 0.00015350609629697 mirMAP -0.121298506170498 0.00813659141021244 NA NA NA hsa-miR-15a-5p NF2 1.42663930007845 1.36006952074963e-57 -0.27390922602413 0.00015350609629697 MirTarget -0.153535725923031 4.28287543092385e-05 NA NA NA hsa-miR-17-5p NF2 0.494260110870015 3.8348005261e-09 -0.27390922602413 0.00015350609629697 mirMAP -0.141499888058306 0.00267543983051817 NA NA NA hsa-miR-20a-5p NF2 0.702602695798242 4.06372887613329e-13 -0.27390922602413 0.00015350609629697 mirMAP -0.211740785298549 8.47235223066342e-08 NA NA NA hsa-miR-2355-5p NF2 1.57515081110162 3.54962327490702e-48 -0.27390922602413 0.00015350609629697 MirTarget;miRNATAP -0.11770436152019 0.000224047402829199 NA NA NA hsa-miR-330-5p NF2 1.44960468659754 2.12131210588035e-45 -0.27390922602413 0.00015350609629697 MirTarget;miRanda -0.13937797925404 3.80838249922941e-05 NA NA NA hsa-miR-93-5p NF2 1.37365940377595 2.37567548683245e-46 -0.27390922602413 0.00015350609629697 mirMAP -0.202776791259222 1.22736940651744e-08 NA NA NA hsa-miR-21-5p NKD1 2.51462371613332 3.30620591950316e-66 -3.29439245553428 2.64736766705843e-49 mirMAP -0.711094610300358 3.54235067812357e-21 NA NA NA hsa-miR-330-5p NKD1 1.44960468659754 2.12131210588035e-45 -3.29439245553428 2.64736766705843e-49 miRanda;miRNATAP -0.962768528936515 1.67421097987696e-16 NA NA NA hsa-miR-340-5p NKD1 1.14479851941741 2.91936881701444e-15 -3.29439245553428 2.64736766705843e-49 mirMAP -0.598735379358832 1.00180349311681e-10 NA NA NA hsa-miR-455-5p NKD1 0.773674551205946 2.12957541541474e-09 -3.29439245553428 2.64736766705843e-49 miRanda -0.608124760658548 1.27060058874825e-08 NA NA NA hsa-miR-616-5p NKD1 0.913426384742148 3.78418389333709e-09 -3.29439245553428 2.64736766705843e-49 mirMAP -0.395602516913126 1.52149535557244e-05 NA NA NA hsa-miR-146b-3p PARD6A 1.20941495066078 2.12939149602665e-10 -1.41719455759815 6.19237049356047e-28 miRNATAP -0.1934409792502 8.02929334514392e-07 NA NA NA hsa-let-7a-3p PARD6B 0.0677487960013088 0.460458477653989 -0.980233460238695 1.01241800505542e-18 MirTarget;miRNATAP -0.305261303865636 1.54822189172596e-05 NA NA NA hsa-let-7b-5p PARD6B 0.770868211539597 6.63408323707647e-21 -0.980233460238695 1.01241800505542e-18 MirTarget;miRNATAP -0.411469818936035 1.96687062721393e-08 NA NA NA hsa-let-7f-1-3p PARD6B 0.477913872379336 4.46669616865068e-05 -0.980233460238695 1.01241800505542e-18 MirTarget -0.271861301564899 3.85998585998538e-06 NA NA NA hsa-let-7i-5p PARD6B 0.911372377723717 7.11483853341932e-31 -0.980233460238695 1.01241800505542e-18 MirTarget;miRNATAP -0.445643491600637 1.42253834936367e-09 NA NA NA hsa-miR-106b-5p PARD6B 1.07509411417907 2.11739194181878e-36 -0.980233460238695 1.01241800505542e-18 MirTarget;miRNATAP -0.484880972653256 1.75905720529449e-13 NA NA NA hsa-miR-140-5p PARD6B 0.504309496243674 3.09884038729031e-11 -0.980233460238695 1.01241800505542e-18 miRanda -0.459519263877883 2.27575545144391e-08 NA NA NA hsa-miR-142-3p PARD6B 1.88928758773299 2.72985643829893e-22 -0.980233460238695 1.01241800505542e-18 PITA;miRanda;miRNATAP -0.175891230808439 7.5646839460354e-09 NA NA NA hsa-miR-143-5p PARD6B 0.297037599500085 0.0442949119420742 -0.980233460238695 1.01241800505542e-18 MirTarget -0.162623328104522 0.00019313354746582 NA NA NA hsa-miR-17-5p PARD6B 0.494260110870015 3.8348005261e-09 -0.980233460238695 1.01241800505542e-18 MirTarget;TargetScan;miRNATAP -0.277551409875962 0.000247789123083223 NA NA NA hsa-miR-18a-5p PARD6B 0.936704393213466 1.05064580570579e-10 -0.980233460238695 1.01241800505542e-18 miRNAWalker2_validate;MirTarget -0.242541371520981 1.22093835579574e-08 NA NA NA hsa-miR-20a-5p PARD6B 0.702602695798242 4.06372887613329e-13 -0.980233460238695 1.01241800505542e-18 MirTarget;miRNATAP -0.258063025611988 6.08843789040765e-05 NA NA NA hsa-miR-223-3p PARD6B 1.23291409735619 1.07767240442694e-17 -0.980233460238695 1.01241800505542e-18 MirTarget -0.33474929012523 2.35315432062443e-16 NA NA NA hsa-miR-2355-3p PARD6B 1.32757890426926 1.88016636795886e-18 -0.980233460238695 1.01241800505542e-18 MirTarget;miRNATAP -0.284466389141016 1.52920874198255e-12 NA NA NA hsa-miR-27a-3p PARD6B 0.558934437526245 1.44256383086177e-12 -0.980233460238695 1.01241800505542e-18 MirTarget;miRNATAP -0.486962023516901 4.64713945928853e-10 NA NA NA hsa-miR-320a PARD6B 0.412740558379182 2.02929519701706e-05 -0.980233460238695 1.01241800505542e-18 miRanda;miRNATAP -0.216580486270953 0.00110044351833557 NA NA NA hsa-miR-320b PARD6B 0.300497419754843 0.0245219177384172 -0.980233460238695 1.01241800505542e-18 miRanda;miRNATAP -0.132032961495128 0.00644591862937385 NA NA NA hsa-miR-338-5p PARD6B 0.628429807914222 1.27575140717947e-06 -0.980233460238695 1.01241800505542e-18 miRNATAP -0.220353650710931 9.25017565844358e-06 NA NA NA hsa-miR-339-5p PARD6B 0.322848334531193 0.0117281778821612 -0.980233460238695 1.01241800505542e-18 miRanda -0.169687025507086 0.000756244482856054 NA NA NA hsa-miR-374a-5p PARD6B 0.543061152108237 2.19403097299769e-14 -0.980233460238695 1.01241800505542e-18 MirTarget;mirMAP -0.48910903824008 1.90684262044229e-08 NA NA NA hsa-miR-374b-5p PARD6B 0.0804104684417872 0.365593963035077 -0.980233460238695 1.01241800505542e-18 miRNAWalker2_validate;MirTarget;mirMAP -0.245474867322661 0.000826647403836184 NA NA NA hsa-miR-381-3p PARD6B -0.674906433524392 0.000234722307243307 -0.980233460238695 1.01241800505542e-18 MirTarget -0.153653381191403 1.13389724326929e-05 NA NA NA hsa-miR-409-3p PARD6B -0.292481246887274 0.114186058216271 -0.980233460238695 1.01241800505542e-18 PITA -0.148863326834513 2.12102468723156e-05 NA NA NA hsa-miR-455-5p PARD6B 0.773674551205946 2.12957541541474e-09 -0.980233460238695 1.01241800505542e-18 miRanda -0.234913127635709 1.19702808361796e-06 NA NA NA hsa-miR-576-5p PARD6B 1.06681109513983 5.69294424466526e-24 -0.980233460238695 1.01241800505542e-18 mirMAP -0.291654250168618 2.25068958647051e-07 NA NA NA hsa-miR-590-3p PARD6B 1.13702599385212 3.53435739887793e-22 -0.980233460238695 1.01241800505542e-18 miRanda;miRNATAP -0.288539304125244 1.34676336393264e-08 NA NA NA hsa-miR-769-5p PARD6B 0.376837385738096 4.45440414144944e-07 -0.980233460238695 1.01241800505542e-18 MirTarget -0.41155336768444 1.44518675794909e-06 NA NA NA hsa-miR-92a-3p PARD6B 0.178194888895831 0.0088835082650834 -0.980233460238695 1.01241800505542e-18 mirMAP -0.270170560223599 0.00509839603682703 NA NA NA hsa-miR-93-5p PARD6B 1.37365940377595 2.37567548683245e-46 -0.980233460238695 1.01241800505542e-18 MirTarget;miRNATAP -0.396466055069602 2.71316903531643e-12 NA NA NA hsa-miR-3913-5p PARD6G 0.136365354811444 0.24239516424369 0.201501925097998 0.0648963405520929 mirMAP -0.190237745667531 0.000457985000115418 NA NA NA hsa-miR-125a-5p PPP1CA -0.561874059994802 7.3931856356891e-13 0.04259230672249 0.50766669128825 miRanda;miRNATAP -0.15770014376225 0.0003073657579704 NA NA NA hsa-let-7a-3p PPP1CB 0.0677487960013088 0.460458477653989 -0.292296573695312 6.6825892291246e-07 mirMAP -0.118867244185861 0.000965310846682263 NA NA NA hsa-miR-140-3p PPP1CB 0.989350547007025 6.14964028267239e-25 -0.292296573695312 6.6825892291246e-07 miRNATAP -0.117486395870044 0.000211586252728097 NA NA NA hsa-miR-181a-5p PPP1CB 1.11111114875339 3.97880443756442e-29 -0.292296573695312 6.6825892291246e-07 mirMAP;miRNATAP -0.139590047150651 3.38966803223089e-06 NA NA NA hsa-miR-181b-5p PPP1CB 1.49054296272357 3.69051660739368e-41 -0.292296573695312 6.6825892291246e-07 mirMAP;miRNATAP -0.114604328435822 9.11486920963154e-06 NA NA NA hsa-miR-338-5p PPP1CB 0.628429807914222 1.27575140717947e-06 -0.292296573695312 6.6825892291246e-07 mirMAP;miRNATAP -0.102389492284032 5.0156280666128e-05 NA NA NA hsa-miR-374b-5p PPP1CB 0.0804104684417872 0.365593963035077 -0.292296573695312 6.6825892291246e-07 mirMAP -0.105657021220227 0.00461707680544089 NA NA NA hsa-miR-455-5p PPP1CB 0.773674551205946 2.12957541541474e-09 -0.292296573695312 6.6825892291246e-07 PITA;miRanda -0.101650531379801 3.70625910158047e-05 NA NA NA hsa-miR-26a-5p PPP1CC -0.202091714279613 0.00166918288801054 0.438198934962318 1.91871496602345e-16 miRNAWalker2_validate -0.132079013594514 0.0063890907984758 NA NA NA hsa-miR-27b-3p PPP1CC -0.699527231242518 1.07356023759234e-15 0.438198934962318 1.91871496602345e-16 miRNATAP -0.264762838462256 2.79695379917814e-16 NA NA NA hsa-miR-30a-5p PPP1CC -0.778411951775343 2.73322451127932e-16 0.438198934962318 1.91871496602345e-16 miRNAWalker2_validate -0.180250310863921 2.62696840295779e-09 NA NA NA hsa-miR-17-3p PPP2CA 0.723795600017259 5.90151677164931e-18 -0.0986621185828058 0.0322311495916405 MirTarget -0.115609136292778 5.1945828551556e-05 NA NA NA hsa-miR-590-3p PPP2CB 1.13702599385212 3.53435739887793e-22 -0.487343407097616 6.12363210381507e-16 miRanda -0.148108586350573 5.65176554878302e-08 NA NA NA hsa-miR-146b-5p PPP2R1B 1.40714170253819 2.9559871816487e-12 -0.454734829935764 5.04192101717804e-14 miRanda -0.106167714667314 4.04187575982608e-11 NA NA NA hsa-miR-15a-5p PPP2R1B 1.42663930007845 1.36006952074963e-57 -0.454734829935764 5.04192101717804e-14 MirTarget -0.158870694074697 7.39147854946692e-07 NA NA NA hsa-miR-15b-5p PPP2R1B 0.773001494057531 1.71784656078957e-16 -0.454734829935764 5.04192101717804e-14 MirTarget -0.155184743390608 9.11437716247661e-06 NA NA NA hsa-miR-16-5p PPP2R1B 0.934012514027655 4.85417898318515e-24 -0.454734829935764 5.04192101717804e-14 miRNAWalker2_validate;MirTarget -0.157201852909443 5.57771892550489e-06 NA NA NA hsa-miR-186-5p PPP2R1B 0.507217561043443 9.04455748270995e-10 -0.454734829935764 5.04192101717804e-14 mirMAP -0.144865494129061 0.000395809025710765 NA NA NA hsa-miR-195-5p PPP2R1B 0.346502644882604 0.0092562828415903 -0.454734829935764 5.04192101717804e-14 MirTarget -0.11856735020381 3.74905556486083e-06 NA NA NA hsa-miR-320a PPP2R1B 0.412740558379182 2.02929519701706e-05 -0.454734829935764 5.04192101717804e-14 miRanda -0.150930956528645 1.79572706330847e-05 NA NA NA hsa-miR-330-5p PPP2R1B 1.44960468659754 2.12131210588035e-45 -0.454734829935764 5.04192101717804e-14 miRanda -0.167386992703103 5.71928058591198e-09 NA NA NA hsa-miR-452-5p PPP2R1B 2.05325688842141 2.82238393643084e-40 -0.454734829935764 5.04192101717804e-14 MirTarget -0.116940593190983 1.2480959791507e-09 NA NA NA hsa-miR-497-5p PPP2R1B 0.227757383708836 0.0600073987853074 -0.454734829935764 5.04192101717804e-14 MirTarget -0.132380804791297 2.85132271643844e-06 NA NA NA hsa-miR-576-5p PPP2R1B 1.06681109513983 5.69294424466526e-24 -0.454734829935764 5.04192101717804e-14 mirMAP -0.107694240077987 0.00039255398459087 NA NA NA hsa-miR-590-3p PPP2R1B 1.13702599385212 3.53435739887793e-22 -0.454734829935764 5.04192101717804e-14 MirTarget;miRanda;mirMAP -0.11445817178589 2.96165176993764e-05 NA NA NA hsa-miR-126-5p PPP2R2B 0.785607261431085 5.77058629454465e-13 -2.59071496355859 1.80864868504118e-46 MirTarget -0.456787294756938 7.12757128741115e-06 NA NA NA hsa-miR-486-5p PPP2R2B 1.16748143760361 1.68410465883829e-08 -2.59071496355859 1.80864868504118e-46 miRanda -0.230822671160867 2.04976602859073e-05 NA NA NA hsa-miR-181a-2-3p PPP2R2C 0.549613348249471 1.48987286432989e-10 0.204865561537737 0.512618305427393 MirTarget -0.726569332821327 0.00021238285944272 NA NA NA hsa-miR-502-3p PPP2R2C -1.10416310320528 1.55354569985732e-22 0.204865561537737 0.512618305427393 MirTarget;PITA;miRNATAP -0.5596435835033 8.09961906626845e-05 NA NA NA hsa-miR-107 PRKCI 0.140046250553248 0.0943611632552367 -0.699597066280502 1.03174229440049e-21 miRanda -0.158842001760043 0.00216930963045784 NA NA NA hsa-miR-126-5p PRKCI 0.785607261431085 5.77058629454465e-13 -0.699597066280502 1.03174229440049e-21 mirMAP -0.162361578909314 1.77357845073285e-05 NA NA NA hsa-miR-140-3p PRKCI 0.989350547007025 6.14964028267239e-25 -0.699597066280502 1.03174229440049e-21 PITA -0.267245574268036 4.65591393761522e-11 NA NA NA hsa-miR-142-5p PRKCI 1.88417391525707 1.2096808039882e-27 -0.699597066280502 1.03174229440049e-21 mirMAP -0.148860747340769 1.81769687525511e-11 NA NA NA hsa-miR-146a-5p PRKCI 1.04938133739924 7.51013231709992e-12 -0.699597066280502 1.03174229440049e-21 MirTarget -0.120551366040984 7.28543548247889e-06 NA NA NA hsa-miR-155-5p PRKCI 3.26274490570809 5.06841441826518e-51 -0.699597066280502 1.03174229440049e-21 miRNAWalker2_validate -0.129042375677777 1.21858258332831e-15 NA NA NA hsa-miR-186-5p PRKCI 0.507217561043443 9.04455748270995e-10 -0.699597066280502 1.03174229440049e-21 MirTarget;mirMAP;miRNATAP -0.153872245942848 0.00256018911486071 NA NA NA hsa-miR-28-5p PRKCI 0.461962042257226 3.32424690573327e-11 -0.699597066280502 1.03174229440049e-21 miRanda -0.334351882006762 2.0948503473997e-08 NA NA NA hsa-miR-361-5p PRKCI 0.0514169367202078 0.382929376393199 -0.699597066280502 1.03174229440049e-21 miRanda -0.212602479553427 0.00453532245521983 NA NA NA hsa-miR-365a-3p PRKCI 0.80809616164259 2.36039522526e-12 -0.699597066280502 1.03174229440049e-21 MirTarget -0.213680540221291 1.48073104216019e-09 NA NA NA hsa-miR-455-5p PRKCI 0.773674551205946 2.12957541541474e-09 -0.699597066280502 1.03174229440049e-21 miRanda -0.192741339676721 1.33593003900796e-09 NA NA NA hsa-miR-590-3p PRKCI 1.13702599385212 3.53435739887793e-22 -0.699597066280502 1.03174229440049e-21 MirTarget;miRanda;mirMAP -0.200236958802765 2.63816329082568e-09 NA NA NA hsa-miR-93-5p PRKCI 1.37365940377595 2.37567548683245e-46 -0.699597066280502 1.03174229440049e-21 miRNAWalker2_validate -0.196200483045281 2.9908726734309e-07 NA NA NA hsa-miR-148b-3p PRKCZ 0.346011252093377 4.27203463315056e-06 -0.704707244926093 4.34222857031105e-13 MirTarget -0.224879661021484 0.0023213820235026 NA NA NA hsa-miR-152-3p PRKCZ 0.187079360533734 0.052276214844753 -0.704707244926093 4.34222857031105e-13 MirTarget -0.169984650958692 0.00341621565584716 NA NA NA hsa-miR-193a-3p PRKCZ 0.849206638484406 3.68101781083335e-14 -0.704707244926093 4.34222857031105e-13 miRanda -0.17635548950887 0.000216459453227069 NA NA NA hsa-miR-590-3p PRKCZ 1.13702599385212 3.53435739887793e-22 -0.704707244926093 4.34222857031105e-13 miRanda -0.238026663992207 5.34402834253736e-08 NA NA NA hsa-miR-429 RASSF1 -2.16569233119434 2.66862243626443e-37 0.627514156520288 6.01360653275305e-17 miRNATAP -0.121144042598097 6.14216894087611e-08 NA NA NA hsa-miR-744-5p RASSF1 -0.348985243196771 0.000187889982228835 0.627514156520288 6.01360653275305e-17 miRNAWalker2_validate -0.13091916416799 0.00479302734956156 NA NA NA hsa-miR-125a-3p RASSF6 -0.372794471295036 0.000941729459601642 0.790882948579614 1.94219106574005e-06 MirTarget;miRanda -0.295383675394355 0.000328976088696327 NA NA NA hsa-miR-127-5p RASSF6 -1.33574359249785 5.73079880594981e-13 0.790882948579614 1.94219106574005e-06 mirMAP -0.211661148812682 1.00313823384557e-05 NA NA NA hsa-miR-130a-3p RASSF6 -0.667386596699886 1.34029167767774e-10 0.790882948579614 1.94219106574005e-06 mirMAP -0.47027276180999 4.53875482537571e-08 NA NA NA hsa-miR-136-5p RASSF6 -1.67696564080585 1.99625416234538e-18 0.790882948579614 1.94219106574005e-06 mirMAP -0.193583942530798 2.25115783703879e-05 NA NA NA hsa-miR-200c-3p RASSF6 -5.40303134829523 2.74173143360645e-94 0.790882948579614 1.94219106574005e-06 MirTarget -0.125825920112705 1.66746501915425e-06 NA NA NA hsa-miR-203a-3p RASSF6 -2.25533513338731 1.77332845294014e-21 0.790882948579614 1.94219106574005e-06 MirTarget -0.106286727084341 0.00378669893943502 NA NA NA hsa-miR-212-3p RASSF6 0.140490094813501 0.298248972687012 0.790882948579614 1.94219106574005e-06 mirMAP -0.29499132089226 1.98003230179579e-05 NA NA NA hsa-miR-218-5p RASSF6 -0.81077534785501 3.0631582201951e-08 0.790882948579614 1.94219106574005e-06 MirTarget;mirMAP -0.412473147242765 9.21341064548904e-12 NA NA NA hsa-miR-335-3p RASSF6 -1.36498175550207 6.84287752180534e-13 0.790882948579614 1.94219106574005e-06 MirTarget -0.194608501290453 3.35359236112977e-05 NA NA NA hsa-miR-335-5p RASSF6 -2.09515619961552 1.03765771499548e-25 0.790882948579614 1.94219106574005e-06 miRNAWalker2_validate -0.264632435145223 4.30434702101889e-10 NA NA NA hsa-miR-363-3p RASSF6 -1.93551166555337 4.45368477487614e-32 0.790882948579614 1.94219106574005e-06 mirMAP -0.167319196217313 0.00109467949647988 NA NA NA hsa-miR-582-5p RASSF6 -0.323404837478908 0.0786820871592677 0.790882948579614 1.94219106574005e-06 mirMAP -0.146368508473458 0.00391973158493308 NA NA NA hsa-miR-103a-3p SAV1 0.779373475434461 7.37867196796994e-20 -0.625335992115435 3.57901619501069e-17 miRNAWalker2_validate -0.32065271874455 4.57202605439938e-12 NA NA NA hsa-miR-107 SAV1 0.140046250553248 0.0943611632552367 -0.625335992115435 3.57901619501069e-17 PITA;miRanda;miRNATAP -0.2354272485429 4.57024899212158e-06 NA NA NA hsa-miR-16-2-3p SAV1 1.3046118743965 4.17207934608428e-19 -0.625335992115435 3.57901619501069e-17 mirMAP -0.167852837904859 6.43505451286469e-10 NA NA NA hsa-miR-16-5p SAV1 0.934012514027655 4.85417898318515e-24 -0.625335992115435 3.57901619501069e-17 miRNAWalker2_validate -0.295683259894764 2.32235783170576e-12 NA NA NA hsa-miR-186-5p SAV1 0.507217561043443 9.04455748270995e-10 -0.625335992115435 3.57901619501069e-17 mirMAP -0.324800213658891 6.59178538461394e-11 NA NA NA hsa-miR-320a SAV1 0.412740558379182 2.02929519701706e-05 -0.625335992115435 3.57901619501069e-17 miRanda -0.153215282672088 0.000499506008606828 NA NA NA hsa-miR-421 SAV1 0.313155739887734 0.020433534776003 -0.625335992115435 3.57901619501069e-17 miRanda -0.12574642593178 0.000119284083421532 NA NA NA hsa-miR-484 SAV1 0.571987778099603 9.67278224458421e-10 -0.625335992115435 3.57901619501069e-17 miRNAWalker2_validate -0.273426127675663 5.34888419210952e-10 NA NA NA hsa-miR-590-3p SAV1 1.13702599385212 3.53435739887793e-22 -0.625335992115435 3.57901619501069e-17 miRanda;mirMAP;miRNATAP -0.203167212957297 1.51278509649863e-09 NA NA NA hsa-miR-616-5p SAV1 0.913426384742148 3.78418389333709e-09 -0.625335992115435 3.57901619501069e-17 mirMAP -0.113822965160902 3.11762661579426e-05 NA NA NA hsa-miR-7-1-3p SAV1 0.544601828025304 5.33830451326047e-07 -0.625335992115435 3.57901619501069e-17 mirMAP -0.16967933506143 1.18818576851473e-05 NA NA NA hsa-miR-186-5p SCRIB 0.507217561043443 9.04455748270995e-10 -0.119600024666974 0.21652979636348 miRNAWalker2_validate -0.170907158164232 0.00695439606961249 NA NA NA hsa-miR-93-3p SCRIB 0.379664250785728 9.76327751780657e-05 -0.119600024666974 0.21652979636348 miRNAWalker2_validate -0.140528772390333 0.00999969208331855 NA NA NA hsa-miR-204-5p SERPINE1 -1.67490789640238 9.14741888352476e-10 1.92970249364449 2.84437942656963e-16 miRNAWalker2_validate -0.36894574634153 2.36125358098929e-15 NA NA NA hsa-miR-30a-5p SERPINE1 -0.778411951775343 2.73322451127932e-16 1.92970249364449 2.84437942656963e-16 miRNATAP -1.43022749865242 6.79980385354922e-30 NA NA NA hsa-miR-30b-5p SERPINE1 -1.18330589477119 6.8341618466966e-27 1.92970249364449 2.84437942656963e-16 MirTarget -0.898818015759768 2.15911007917366e-16 25170877 miR-30b may function as a novel tumor suppressor gene in gastric cancer by targeting PAI-1 and regulating the apoptosis of cancer cells gastric cancer hsa-miR-30c-5p SERPINE1 -1.08783070774238 2.02505402525786e-24 1.92970249364449 2.84437942656963e-16 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -1.08355371642794 3.40127651324715e-22 NA NA NA hsa-miR-30d-5p SERPINE1 -0.202727675788184 0.00659067084745794 1.92970249364449 2.84437942656963e-16 miRNATAP -1.30372212824368 3.11670391718996e-13 NA NA NA hsa-miR-514a-3p SERPINE1 -3.60916038800272 7.44698991540685e-35 1.92970249364449 2.84437942656963e-16 MirTarget -0.254217949872863 4.98891418851513e-10 NA NA NA hsa-miR-99a-5p SERPINE1 -0.609395142445514 1.66643233447031e-07 1.92970249364449 2.84437942656963e-16 miRNAWalker2_validate -0.700232387065003 5.61135213392081e-10 NA NA NA hsa-miR-16-5p SMAD1 0.934012514027655 4.85417898318515e-24 -0.421677989471699 9.05319415824374e-08 miRNAWalker2_validate -0.208250636350146 2.62867081970144e-06 NA NA NA hsa-miR-421 SMAD1 0.313155739887734 0.020433534776003 -0.421677989471699 9.05319415824374e-08 PITA;miRanda -0.107624592112208 0.00144457794830444 NA NA NA hsa-miR-590-3p SMAD1 1.13702599385212 3.53435739887793e-22 -0.421677989471699 9.05319415824374e-08 PITA;miRanda -0.167852293568058 1.60785234854449e-06 NA NA NA hsa-miR-590-5p SMAD1 0.709763558412506 1.11883921359361e-11 -0.421677989471699 9.05319415824374e-08 miRanda -0.177243426833821 1.43363474828238e-05 NA NA NA hsa-miR-106b-5p SMAD2 1.07509411417907 2.11739194181878e-36 -0.323525857741032 2.23720043114496e-11 mirMAP -0.227921158638246 1.08811372967107e-16 NA NA NA hsa-miR-142-5p SMAD2 1.88417391525707 1.2096808039882e-27 -0.323525857741032 2.23720043114496e-11 mirMAP;miRNATAP -0.103618518834479 1.24250681485868e-13 NA NA NA hsa-miR-148b-3p SMAD2 0.346011252093377 4.27203463315056e-06 -0.323525857741032 2.23720043114496e-11 MirTarget;mirMAP -0.159371781791692 9.32204012025227e-06 NA NA NA hsa-miR-181a-5p SMAD2 1.11111114875339 3.97880443756442e-29 -0.323525857741032 2.23720043114496e-11 mirMAP -0.111196305883891 9.05817772311089e-06 24394555 Here we show that miR-181a promotes TGF-β-mediated epithelial-to-mesenchymal transition via repression of its functional target Smad7 miR-181a and phosphorylated Smad2 are enriched in recurrent compared with matched-primary ovarian tumours and their expression is associated with shorter time to recurrence and poor outcome in patients with EOC recurrence ovarian cancer hsa-miR-181b-5p SMAD2 1.49054296272357 3.69051660739368e-41 -0.323525857741032 2.23720043114496e-11 mirMAP -0.121061562672026 1.31421344246454e-08 NA NA NA hsa-miR-186-5p SMAD2 0.507217561043443 9.04455748270995e-10 -0.323525857741032 2.23720043114496e-11 mirMAP -0.119891748076015 0.000207363898523546 NA NA NA hsa-miR-28-3p SMAD2 1.01277915413238 1.8655970171461e-43 -0.323525857741032 2.23720043114496e-11 mirMAP -0.161662869809801 6.30266644116871e-07 NA NA NA hsa-miR-361-3p SMAD2 1.08992546227594 1.13197240706704e-36 -0.323525857741032 2.23720043114496e-11 miRNATAP -0.164501760249365 3.64651837826174e-09 22675530 Functional analyses showed that Smad2 and TGFß1 are not dysregulated by miR-361-3p and miR-625* in the lung cell line A549 respectively lung cancer hsa-miR-361-5p SMAD2 0.0514169367202078 0.382929376393199 -0.323525857741032 2.23720043114496e-11 MirTarget -0.143014051357446 0.00265133449369938 NA NA NA hsa-miR-3613-5p SMAD2 1.6648190889407 3.78720979041391e-41 -0.323525857741032 2.23720043114496e-11 mirMAP -0.131514745649209 3.84595509882195e-12 NA NA NA hsa-miR-374a-3p SMAD2 1.13863935833993 2.79089304015401e-44 -0.323525857741032 2.23720043114496e-11 mirMAP -0.1697571733512 3.62987531624032e-09 NA NA NA hsa-miR-374a-5p SMAD2 0.543061152108237 2.19403097299769e-14 -0.323525857741032 2.23720043114496e-11 MirTarget -0.153917787865928 3.39287856117158e-05 NA NA NA hsa-miR-455-5p SMAD2 0.773674551205946 2.12957541541474e-09 -0.323525857741032 2.23720043114496e-11 miRanda -0.10107849465895 7.22542945679077e-07 NA NA NA hsa-miR-484 SMAD2 0.571987778099603 9.67278224458421e-10 -0.323525857741032 2.23720043114496e-11 miRNAWalker2_validate -0.114497326283267 5.78354380226944e-05 NA NA NA hsa-miR-590-3p SMAD2 1.13702599385212 3.53435739887793e-22 -0.323525857741032 2.23720043114496e-11 MirTarget;PITA;mirMAP;miRNATAP -0.103830667568495 1.50902215009462e-06 NA NA NA hsa-miR-769-5p SMAD2 0.376837385738096 4.45440414144944e-07 -0.323525857741032 2.23720043114496e-11 MirTarget;PITA;miRNATAP -0.110502416552027 0.0024196210430541 NA NA NA hsa-miR-15a-5p SMAD3 1.42663930007845 1.36006952074963e-57 -0.244139438487666 3.92004830247932e-05 MirTarget -0.146828051928466 1.64894295267973e-06 NA NA NA hsa-miR-185-5p SMAD3 1.05056378692621 1.31174187880682e-22 -0.244139438487666 3.92004830247932e-05 MirTarget -0.120508170275662 2.37794014383956e-05 NA NA NA hsa-miR-186-5p SMAD3 0.507217561043443 9.04455748270995e-10 -0.244139438487666 3.92004830247932e-05 mirMAP -0.123358679164461 0.00159252671121764 NA NA NA hsa-miR-28-5p SMAD3 0.461962042257226 3.32424690573327e-11 -0.244139438487666 3.92004830247932e-05 miRNATAP -0.19375315100781 2.75344519177763e-05 NA NA NA hsa-miR-330-5p SMAD3 1.44960468659754 2.12131210588035e-45 -0.244139438487666 3.92004830247932e-05 miRanda -0.113884725915202 4.1000924834805e-05 NA NA NA hsa-miR-106b-5p SMAD4 1.07509411417907 2.11739194181878e-36 -0.353252154932229 3.49222750370295e-11 mirMAP;miRNATAP -0.263637533078296 2.2876546815193e-18 NA NA NA hsa-miR-130b-3p SMAD4 1.12788913578446 2.939369462276e-16 -0.353252154932229 3.49222750370295e-11 miRNAWalker2_validate;miRNATAP -0.162522896714783 4.30068548257445e-16 NA NA NA hsa-miR-140-5p SMAD4 0.504309496243674 3.09884038729031e-11 -0.353252154932229 3.49222750370295e-11 miRanda -0.107841915991596 0.00567505288961576 NA NA NA hsa-miR-142-5p SMAD4 1.88417391525707 1.2096808039882e-27 -0.353252154932229 3.49222750370295e-11 mirMAP -0.124573552703085 3.87297476256703e-16 NA NA NA hsa-miR-146b-5p SMAD4 1.40714170253819 2.9559871816487e-12 -0.353252154932229 3.49222750370295e-11 PITA;miRanda;miRNATAP -0.111309409867936 7.89967750234915e-16 21874046;26883911 MicroRNA miR 146b 5p regulates signal transduction of TGF β by repressing SMAD4 in thyroid cancer; A computational search revealed that miR-146b-5p putatively binds to the 3' untranslated region UTR of SMAD4 an important member of the transforming growth factor β TGF-β signaling pathway; Luciferase reporter assay confirmed the direct binding of miR-146b-5p on the SMAD4 3'UTR; Specific inhibition of miR-146b-5p with a locked nucleic acid-modified anti-miR-146b oligonucleotide significantly increased SMAD4 levels in the human papillary carcinoma cell lines TPC-1 and BCPAP; The overexpression of miR-146b-5p in normal rat follicular PCCL3 cells decreased SMAD4 levels and disrupted TGF-β signal transduction;The overexpression of SMAD4 in BCPAP cells a validated target of miR-146b-5p and key protein in the TGF-β signaling pathway inhibited migration similarly to the effects observed with the antagomiR 146b-5p ; thyroid cancer;thyroid cancer hsa-miR-17-5p SMAD4 0.494260110870015 3.8348005261e-09 -0.353252154932229 3.49222750370295e-11 miRNAWalker2_validate;miRTarBase;mirMAP;miRNATAP -0.10418923812489 0.00325465373100142 NA NA NA hsa-miR-186-5p SMAD4 0.507217561043443 9.04455748270995e-10 -0.353252154932229 3.49222750370295e-11 miRNAWalker2_validate;mirMAP -0.177554906278362 5.12602285863497e-07 NA NA NA hsa-miR-18a-5p SMAD4 0.936704393213466 1.05064580570579e-10 -0.353252154932229 3.49222750370295e-11 miRNAWalker2_validate -0.128383600075071 6.85100350670596e-11 NA NA NA hsa-miR-21-3p SMAD4 1.78837590049697 1.41655409877312e-33 -0.353252154932229 3.49222750370295e-11 mirMAP -0.14165903491177 7.06231943439386e-16 NA NA NA hsa-miR-25-3p SMAD4 1.12016166564779 3.79069348635778e-48 -0.353252154932229 3.49222750370295e-11 mirMAP -0.170081576681957 4.0925836995647e-07 NA NA NA hsa-miR-27a-3p SMAD4 0.558934437526245 1.44256383086177e-12 -0.353252154932229 3.49222750370295e-11 MirTarget -0.184807695672174 5.04606618085533e-07 NA NA NA hsa-miR-28-3p SMAD4 1.01277915413238 1.8655970171461e-43 -0.353252154932229 3.49222750370295e-11 mirMAP -0.207433269425429 5.47829137446523e-09 NA NA NA hsa-miR-28-5p SMAD4 0.461962042257226 3.32424690573327e-11 -0.353252154932229 3.49222750370295e-11 miRanda;miRNATAP -0.21240385695608 4.4009301490775e-07 NA NA NA hsa-miR-34a-5p SMAD4 1.07544567720768 1.81510842038009e-20 -0.353252154932229 3.49222750370295e-11 miRNATAP -0.1492964045371 4.41797602386054e-10 22750848 Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network; Specifically in glioblastoma within the context of the global network promoter enrichment analysis of network edges uncovered a novel regulation of TGF-β signaling via a Smad4 transcriptomic network by miR-34a glioblastoma hsa-miR-374a-5p SMAD4 0.543061152108237 2.19403097299769e-14 -0.353252154932229 3.49222750370295e-11 mirMAP -0.174206701078802 2.102512853859e-05 NA NA NA hsa-miR-454-3p SMAD4 0.68285296887698 1.17407812677787e-08 -0.353252154932229 3.49222750370295e-11 miRNAWalker2_validate;miRNATAP -0.110750938966582 5.950349811848e-06 NA NA NA hsa-miR-550a-3p SMAD4 1.11969632674498 4.64306608686e-12 -0.353252154932229 3.49222750370295e-11 mirMAP -0.106391130547082 3.02572283040143e-08 NA NA NA hsa-miR-576-5p SMAD4 1.06681109513983 5.69294424466526e-24 -0.353252154932229 3.49222750370295e-11 mirMAP -0.136869509225643 1.80782557368588e-07 NA NA NA hsa-miR-589-5p SMAD4 0.696241532021631 5.26958362886071e-16 -0.353252154932229 3.49222750370295e-11 miRNATAP -0.193467970204694 5.08567008607218e-09 NA NA NA hsa-miR-590-3p SMAD4 1.13702599385212 3.53435739887793e-22 -0.353252154932229 3.49222750370295e-11 MirTarget;PITA;miRanda;miRNATAP -0.131595936977223 2.76221280456342e-08 NA NA NA hsa-miR-590-5p SMAD4 0.709763558412506 1.11883921359361e-11 -0.353252154932229 3.49222750370295e-11 miRanda -0.118750766795147 1.98749735856504e-05 NA NA NA hsa-miR-625-5p SMAD4 0.153090549230629 0.330314026509869 -0.353252154932229 3.49222750370295e-11 MirTarget -0.106797654899829 1.9034803009163e-07 NA NA NA hsa-miR-92b-3p SMAD4 0.418630595140165 6.50466149211154e-05 -0.353252154932229 3.49222750370295e-11 mirMAP -0.15850878585623 1.70467008693526e-08 NA NA NA hsa-miR-93-5p SMAD4 1.37365940377595 2.37567548683245e-46 -0.353252154932229 3.49222750370295e-11 miRNAWalker2_validate;mirMAP;miRNATAP -0.149231105698466 2.4808337153461e-08 NA NA NA hsa-miR-182-5p SMAD7 -0.608710746044567 0.0025264935278104 -0.0853391188872612 0.344887733952 miRNATAP -0.111555210176646 4.22027511653404e-06 NA NA NA hsa-miR-21-3p SMAD7 1.78837590049697 1.41655409877312e-33 -0.0853391188872612 0.344887733952 MirTarget -0.111058738994818 0.000221778295324949 23372687;27185036;26531758 Furthermore the expression of MSH2 and SMAD7 two important molecules involving TGF-β pathway was restored following miR-21 knockdown in both MCF-7 and Hs578T breast cancer cells;MicroRNA 21 Regulates Non Small Cell Lung Cancer Cell Invasion and Chemo Sensitivity through SMAD7; We performed bioinformatics analyses on the binding of microRNA-21 miR-21 to the 3'-UTR of SMAD7 mRNA and verified the biological effects of this binding using promoter luciferase reporter assay; Furthermore expression of miR-21 was found to be inhibited by Carboplatin and bioinformatics analyses showed that miR-21 targeted the 3'-UTR of SMAD7 mRNA to inhibit its translation which was confirmed by luciferase reporter assay; Carboplatin may upregulate SMAD7 through suppression of miR-21 to inhibit TGFβ receptor signaling mediated NSCLC cell invasion;MicroRNA 21 induces breast cancer cell invasion and migration by suppressing smad7 via EGF and TGF β pathways; The present study was undertaken to determine the association of miR-21 smad7 EGF and TGF-β with breast cancer cell invasion and migration and to identify the molecular mechanisms involved using immunohistochemistry and western blot analysis; Smad7 was confirmed to be a direct target of miR-21 by luciferase reporter and western blot assays; The downregulation of smad7 by miR-21 or sismad7 enhanced EGF-dependent invasion and migration as well as TGF-β-dependent invasion and migration; The actions of miR-21 were abrogated by expressing a modified smad7 cDNA resistant to miR-21; In conclusion our results demonstrated that plasma miR-21 levels may serve as a diagnostic marker in breast cancers whereas miR-21 promotes breast cancer cell proliferation and invasion by suppressing smad7 which enhances EGF and TGF-β pathways ;; breast cancer;lung squamous cell cancer;breast cancer hsa-miR-324-3p SMAD7 -0.197662887871899 0.0298845059559819 -0.0853391188872612 0.344887733952 MirTarget -0.175517106451734 0.00140617620820728 NA NA NA hsa-miR-34a-5p SMAD7 1.07544567720768 1.81510842038009e-20 -0.0853391188872612 0.344887733952 MirTarget -0.138844976160143 0.000561785951389698 NA NA NA hsa-miR-671-5p SMAD7 0.740296481994777 8.07053661008188e-07 -0.0853391188872612 0.344887733952 PITA -0.14502187400159 9.05408685187864e-06 NA NA NA hsa-miR-107 SNAI2 0.140046250553248 0.0943611632552367 -0.356427634692673 0.0129979444851688 miRanda -0.306761793705569 0.00133520032495645 NA NA NA hsa-miR-148b-3p SNAI2 0.346011252093377 4.27203463315056e-06 -0.356427634692673 0.0129979444851688 miRNAWalker2_validate -0.344852018746948 0.00104190652326892 NA NA NA hsa-miR-200b-3p SNAI2 -1.70383252137161 2.38979336321755e-30 -0.356427634692673 0.0129979444851688 TargetScan -0.228745245252803 1.8598022178794e-06 NA NA NA hsa-miR-429 SNAI2 -2.16569233119434 2.66862243626443e-37 -0.356427634692673 0.0129979444851688 PITA;miRanda;miRNATAP -0.159866688950626 0.000110424269096433 NA NA NA hsa-miR-532-5p SNAI2 -1.09700348358668 8.34836230254408e-26 -0.356427634692673 0.0129979444851688 PITA -0.190823518677431 0.00678741605783006 NA NA NA hsa-miR-140-5p STK3 0.504309496243674 3.09884038729031e-11 -0.540359724243562 2.30136904058358e-19 PITA;miRanda -0.159340764921247 0.000404919787031997 NA NA NA hsa-miR-28-3p STK3 1.01277915413238 1.8655970171461e-43 -0.540359724243562 2.30136904058358e-19 MirTarget;PITA -0.198020481982223 1.94817986558897e-06 NA NA NA hsa-miR-342-3p STK3 1.4124432570595 1.07208971556131e-28 -0.540359724243562 2.30136904058358e-19 miRanda -0.12033810280856 1.36505230755684e-06 NA NA NA hsa-miR-125a-5p TCF7 -0.561874059994802 7.3931856356891e-13 0.800983591334396 2.32781955910614e-08 miRanda -0.351654489054745 0.000453312167919834 NA NA NA hsa-miR-30a-3p TCF7 -0.955360819934585 1.97009535429185e-20 0.800983591334396 2.32781955910614e-08 mirMAP -0.432566886350102 2.38306454151395e-09 NA NA NA hsa-miR-30c-2-3p TCF7 -1.28402709024345 6.77577627955178e-25 0.800983591334396 2.32781955910614e-08 mirMAP -0.470300813821051 3.08381434439972e-16 NA NA NA hsa-miR-106b-5p TCF7L1 1.07509411417907 2.11739194181878e-36 -0.353358651576814 0.000636790820005788 MirTarget -0.201662989374514 0.000826523926568361 NA NA NA hsa-miR-130b-5p TCF7L1 0.92990617673277 3.75880436852717e-12 -0.353358651576814 0.000636790820005788 MirTarget -0.125537019457948 0.00245869850570135 NA NA NA hsa-miR-142-5p TCF7L1 1.88417391525707 1.2096808039882e-27 -0.353358651576814 0.000636790820005788 PITA -0.172408152881014 7.71722229427548e-09 NA NA NA hsa-miR-15b-3p TCF7L1 1.49422666971434 5.44139893275088e-29 -0.353358651576814 0.000636790820005788 miRNATAP -0.137547474080023 0.000450535402488001 NA NA NA hsa-miR-185-3p TCF7L1 0.993379985307475 2.62011454953707e-13 -0.353358651576814 0.000636790820005788 MirTarget -0.172895415794953 2.48596448017815e-05 NA NA NA hsa-miR-330-5p TCF7L1 1.44960468659754 2.12131210588035e-45 -0.353358651576814 0.000636790820005788 miRanda -0.158576321293599 0.00110943545739978 NA NA NA hsa-miR-590-3p TCF7L1 1.13702599385212 3.53435739887793e-22 -0.353358651576814 0.000636790820005788 PITA;miRanda;miRNATAP -0.243023154608187 7.37033348059868e-08 NA NA NA hsa-miR-93-5p TCF7L1 1.37365940377595 2.37567548683245e-46 -0.353358651576814 0.000636790820005788 MirTarget -0.191557132325036 0.000207674858745899 NA NA NA hsa-let-7g-3p TCF7L2 -0.265047454512772 0.0213585204640049 0.132860579589423 0.0157537353263589 MirTarget;miRNATAP -0.122175872375662 2.64125568776328e-06 NA NA NA hsa-miR-148b-3p TCF7L2 0.346011252093377 4.27203463315056e-06 0.132860579589423 0.0157537353263589 miRNAWalker2_validate -0.123053699025516 0.00215054157997715 NA NA NA hsa-miR-186-5p TCF7L2 0.507217561043443 9.04455748270995e-10 0.132860579589423 0.0157537353263589 mirMAP -0.114110140224956 0.00146204723406782 NA NA NA hsa-miR-625-5p TCF7L2 0.153090549230629 0.330314026509869 0.132860579589423 0.0157537353263589 MirTarget -0.122861050480169 1.76214399156583e-09 NA NA NA hsa-miR-664a-3p TCF7L2 -0.019312777079624 0.825861598748857 0.132860579589423 0.0157537353263589 MirTarget -0.120309945868808 0.000529500336490339 NA NA NA hsa-let-7a-3p TEAD1 0.0677487960013088 0.460458477653989 -0.431123997868435 4.95455013573979e-11 MirTarget -0.135080171991313 0.000928342326337855 NA NA NA hsa-let-7f-1-3p TEAD1 0.477913872379336 4.46669616865068e-05 -0.431123997868435 4.95455013573979e-11 MirTarget -0.112933245616224 0.000914440926408262 NA NA NA hsa-miR-101-3p TEAD1 0.683973909682285 2.88573524246948e-15 -0.431123997868435 4.95455013573979e-11 mirMAP -0.148949412189866 0.000301535402681425 NA NA NA hsa-miR-103a-3p TEAD1 0.779373475434461 7.37867196796994e-20 -0.431123997868435 4.95455013573979e-11 mirMAP -0.200850888261996 8.5354461631398e-07 NA NA NA hsa-miR-106b-5p TEAD1 1.07509411417907 2.11739194181878e-36 -0.431123997868435 4.95455013573979e-11 mirMAP -0.331816208271364 3.51958336224963e-19 NA NA NA hsa-miR-128-3p TEAD1 0.475045893035043 2.6255647468e-06 -0.431123997868435 4.95455013573979e-11 MirTarget -0.103189031441334 0.00461453494962469 NA NA NA hsa-miR-130b-3p TEAD1 1.12788913578446 2.939369462276e-16 -0.431123997868435 4.95455013573979e-11 mirMAP -0.146442590760862 6.65000487599266e-09 NA NA NA hsa-miR-140-3p TEAD1 0.989350547007025 6.14964028267239e-25 -0.431123997868435 4.95455013573979e-11 miRNATAP -0.152236032894332 2.11574843529131e-05 NA NA NA hsa-miR-151a-3p TEAD1 0.657909055193034 1.46651056355997e-25 -0.431123997868435 4.95455013573979e-11 mirMAP -0.182362292690828 0.00100115816779766 NA NA NA hsa-miR-15b-3p TEAD1 1.49422666971434 5.44139893275088e-29 -0.431123997868435 4.95455013573979e-11 mirMAP -0.10714182990897 2.24235155270128e-05 NA NA NA hsa-miR-16-1-3p TEAD1 1.51429140700091 3.17219833254498e-37 -0.431123997868435 4.95455013573979e-11 MirTarget;mirMAP -0.126154819397964 6.95278652739893e-06 NA NA NA hsa-miR-16-2-3p TEAD1 1.3046118743965 4.17207934608428e-19 -0.431123997868435 4.95455013573979e-11 mirMAP -0.115699143818911 1.10345800891381e-06 NA NA NA hsa-miR-17-5p TEAD1 0.494260110870015 3.8348005261e-09 -0.431123997868435 4.95455013573979e-11 mirMAP -0.128391347755778 0.00326255037227942 NA NA NA hsa-miR-181a-5p TEAD1 1.11111114875339 3.97880443756442e-29 -0.431123997868435 4.95455013573979e-11 mirMAP;miRNATAP -0.138397982467816 5.11525992850198e-05 NA NA NA hsa-miR-181b-5p TEAD1 1.49054296272357 3.69051660739368e-41 -0.431123997868435 4.95455013573979e-11 mirMAP;miRNATAP -0.12782992698119 1.25767372993218e-05 NA NA NA hsa-miR-185-5p TEAD1 1.05056378692621 1.31174187880682e-22 -0.431123997868435 4.95455013573979e-11 MirTarget;miRNATAP -0.147741953420997 4.17382063625727e-06 NA NA NA hsa-miR-19a-3p TEAD1 0.722913586880779 2.76301458932381e-10 -0.431123997868435 4.95455013573979e-11 mirMAP -0.105697260562618 0.000817808073886038 NA NA NA hsa-miR-19b-3p TEAD1 0.195940928879427 0.0300512922542325 -0.431123997868435 4.95455013573979e-11 mirMAP -0.136277883348419 0.00097934181938043 NA NA NA hsa-miR-20a-5p TEAD1 0.702602695798242 4.06372887613329e-13 -0.431123997868435 4.95455013573979e-11 mirMAP -0.151079688833867 4.30428962440221e-05 NA NA NA hsa-miR-22-5p TEAD1 -0.197038086012602 0.106234828461117 -0.431123997868435 4.95455013573979e-11 mirMAP -0.127506873598321 2.62787612599943e-05 NA NA NA hsa-miR-223-3p TEAD1 1.23291409735619 1.07767240442694e-17 -0.431123997868435 4.95455013573979e-11 mirMAP -0.143537540731006 2.19246157024142e-09 NA NA NA hsa-miR-23a-3p TEAD1 0.761438723382355 4.09310879199257e-27 -0.431123997868435 4.95455013573979e-11 mirMAP;miRNATAP -0.171278041453701 0.000458967880879383 NA NA NA hsa-miR-25-3p TEAD1 1.12016166564779 3.79069348635778e-48 -0.431123997868435 4.95455013573979e-11 miRNATAP -0.201556471953353 1.16335713440341e-06 NA NA NA hsa-miR-27a-3p TEAD1 0.558934437526245 1.44256383086177e-12 -0.431123997868435 4.95455013573979e-11 miRNATAP -0.283150646857303 2.69369464436026e-10 NA NA NA hsa-miR-29c-3p TEAD1 -0.238671318446745 0.0141475322347596 -0.431123997868435 4.95455013573979e-11 mirMAP -0.109668669556563 0.00425044906483674 NA NA NA hsa-miR-32-5p TEAD1 0.407826130035097 7.26884631998646e-06 -0.431123997868435 4.95455013573979e-11 miRNATAP -0.190752664602296 2.10326497996845e-06 NA NA NA hsa-miR-340-5p TEAD1 1.14479851941741 2.91936881701444e-15 -0.431123997868435 4.95455013573979e-11 mirMAP -0.104590325178233 1.71283094168574e-05 NA NA NA hsa-miR-576-5p TEAD1 1.06681109513983 5.69294424466526e-24 -0.431123997868435 4.95455013573979e-11 mirMAP -0.119046266135076 0.000269457850540452 NA NA NA hsa-miR-590-3p TEAD1 1.13702599385212 3.53435739887793e-22 -0.431123997868435 4.95455013573979e-11 MirTarget;PITA;miRanda;miRNATAP -0.166151422530421 1.21243080249382e-08 NA NA NA hsa-miR-92b-3p TEAD1 0.418630595140165 6.50466149211154e-05 -0.431123997868435 4.95455013573979e-11 miRNATAP -0.14333453956851 4.31361734560233e-05 NA NA NA hsa-miR-93-5p TEAD1 1.37365940377595 2.37567548683245e-46 -0.431123997868435 4.95455013573979e-11 mirMAP -0.153017690260904 4.17353049792938e-06 NA NA NA hsa-miR-423-5p TEAD2 0.250929012519631 0.00288495915028486 -0.460735846933191 1.10875013577514e-06 MirTarget -0.170358491895162 0.00706857449443848 NA NA NA hsa-miR-101-3p TEAD3 0.683973909682285 2.88573524246948e-15 -0.332045436056305 3.89674890579768e-05 miRNATAP -0.175848881779691 0.000416081223717753 NA NA NA hsa-miR-331-3p TEAD3 0.431607034018882 6.83022920590941e-05 -0.332045436056305 3.89674890579768e-05 mirMAP -0.111907243572469 0.00663675442441971 NA NA NA hsa-miR-139-5p TGFB1 -0.704802495091118 2.36904108453776e-06 1.54700279831576 2.78812914754058e-38 miRanda -0.229663915619583 2.28216718397939e-06 NA NA NA hsa-miR-744-5p TGFB1 -0.348985243196771 0.000187889982228835 1.54700279831576 2.78812914754058e-38 miRNAWalker2_validate;miRNATAP -0.399940904532963 3.45780106724256e-07 NA NA NA hsa-miR-107 TGFB2 0.140046250553248 0.0943611632552367 -0.469336292045935 0.000490251477006724 miRanda -0.559933447086514 2.03481629875917e-10 NA NA NA hsa-miR-130b-3p TGFB2 1.12788913578446 2.939369462276e-16 -0.469336292045935 0.000490251477006724 MirTarget;miRNATAP -0.156580751578969 0.00249097420975105 NA NA NA hsa-miR-142-5p TGFB2 1.88417391525707 1.2096808039882e-27 -0.469336292045935 0.000490251477006724 mirMAP -0.127254748923374 0.00130803131995633 NA NA NA hsa-miR-148a-3p TGFB2 0.343233211643815 0.00402279073598165 -0.469336292045935 0.000490251477006724 MirTarget;miRNATAP -0.246846036181106 7.29697456550998e-05 NA NA NA hsa-miR-148b-3p TGFB2 0.346011252093377 4.27203463315056e-06 -0.469336292045935 0.000490251477006724 MirTarget -0.360468526268224 0.000268375188449583 NA NA NA hsa-miR-193b-3p TGFB2 -0.273325765316079 0.104328826585392 -0.469336292045935 0.000490251477006724 MirTarget;miRNATAP -0.167973598355945 0.000145171044419197 NA NA NA hsa-miR-21-5p TGFB2 2.51462371613332 3.30620591950316e-66 -0.469336292045935 0.000490251477006724 miRNAWalker2_validate -0.131173211686422 0.00157690783662872 NA NA NA hsa-miR-29b-3p TGFB2 -0.228125979913806 0.0271621721891603 -0.469336292045935 0.000490251477006724 miRTarBase;MirTarget;miRNATAP -0.289170386615493 6.28377322853352e-05 NA NA NA hsa-miR-331-5p TGFB2 0.661186030542026 1.83628790002785e-08 -0.469336292045935 0.000490251477006724 miRNATAP -0.235323703080359 0.000288389309217486 NA NA NA hsa-miR-361-5p TGFB2 0.0514169367202078 0.382929376393199 -0.469336292045935 0.000490251477006724 miRNATAP -0.593277310323935 4.29304373395412e-06 NA NA NA hsa-miR-362-3p TGFB2 -0.753214251798232 3.0025661608035e-07 -0.469336292045935 0.000490251477006724 miRanda -0.151802483500752 0.00324883313613339 NA NA NA hsa-miR-374b-5p TGFB2 0.0804104684417872 0.365593963035077 -0.469336292045935 0.000490251477006724 mirMAP -0.302286565852539 0.000359174717531722 NA NA NA hsa-miR-454-3p TGFB2 0.68285296887698 1.17407812677787e-08 -0.469336292045935 0.000490251477006724 MirTarget;miRNATAP -0.186190333634062 0.00234395713860443 NA NA NA hsa-miR-590-3p TGFB2 1.13702599385212 3.53435739887793e-22 -0.469336292045935 0.000490251477006724 mirMAP -0.293207073092184 6.78797834982813e-07 NA NA NA hsa-miR-590-5p TGFB2 0.709763558412506 1.11883921359361e-11 -0.469336292045935 0.000490251477006724 miRanda;miRNATAP -0.256415439338522 0.000214547512438195 NA NA NA hsa-miR-616-5p TGFB2 0.913426384742148 3.78418389333709e-09 -0.469336292045935 0.000490251477006724 mirMAP -0.229064681057646 1.30218112799715e-06 NA NA NA hsa-miR-10a-5p TGFB3 -1.17164272592931 4.86621098042279e-24 0.891364650319448 3.84674758127802e-13 miRNAWalker2_validate -0.195492012609065 0.000520343467974493 NA NA NA hsa-miR-29b-3p TGFB3 -0.228125979913806 0.0271621721891603 0.891364650319448 3.84674758127802e-13 miRTarBase -0.21513711549002 0.00161883134704875 NA NA NA hsa-let-7d-5p TGFBR1 -0.0696879530236796 0.333110939877203 -0.139407625805428 0.0562036856015428 miRNAWalker2_validate;miRNATAP -0.161415640377896 0.0044449462418102 NA NA NA hsa-miR-101-3p TGFBR1 0.683973909682285 2.88573524246948e-15 -0.139407625805428 0.0562036856015428 miRNAWalker2_validate;miRNATAP -0.167025520155563 0.000175230182764941 NA NA NA hsa-miR-101-5p TGFBR1 -0.710089604234471 1.19159750684491e-09 -0.139407625805428 0.0562036856015428 mirMAP -0.104223311111533 0.00191673760816897 NA NA NA hsa-miR-126-5p TGFBR1 0.785607261431085 5.77058629454465e-13 -0.139407625805428 0.0562036856015428 mirMAP;miRNATAP -0.122965557743085 0.000540912677005276 NA NA NA hsa-miR-128-3p TGFBR1 0.475045893035043 2.6255647468e-06 -0.139407625805428 0.0562036856015428 miRNAWalker2_validate;miRTarBase -0.125843981727141 0.00136614048950141 NA NA NA hsa-miR-338-5p TGFBR1 0.628429807914222 1.27575140717947e-06 -0.139407625805428 0.0562036856015428 PITA;mirMAP;miRNATAP -0.117931437209265 0.000139480841045501 NA NA NA hsa-miR-361-5p TGFBR1 0.0514169367202078 0.382929376393199 -0.139407625805428 0.0562036856015428 miRanda;mirMAP;miRNATAP -0.260839310266332 0.000182561053501575 NA NA NA hsa-miR-374b-5p TGFBR1 0.0804104684417872 0.365593963035077 -0.139407625805428 0.0562036856015428 mirMAP -0.123179331066532 0.00702262805352141 NA NA NA hsa-miR-98-5p TGFBR1 0.0569715596189075 0.450575962846765 -0.139407625805428 0.0562036856015428 miRNAWalker2_validate -0.208111603369397 0.000107570382009014 NA NA NA hsa-miR-106b-5p TGFBR2 1.07509411417907 2.11739194181878e-36 -0.392800266100506 0.000685075520210389 miRNATAP -0.349038258399988 1.61435063203469e-07 NA NA NA hsa-miR-130b-3p TGFBR2 1.12788913578446 2.939369462276e-16 -0.392800266100506 0.000685075520210389 miRNAWalker2_validate;miRNATAP -0.185326136530808 2.70386843045027e-05 25024357 Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC lung squamous cell cancer hsa-miR-18a-5p TGFBR2 0.936704393213466 1.05064580570579e-10 -0.392800266100506 0.000685075520210389 miRNAWalker2_validate -0.16961355943703 7.30860641372394e-05 NA NA NA hsa-miR-21-5p TGFBR2 2.51462371613332 3.30620591950316e-66 -0.392800266100506 0.000685075520210389 miRNAWalker2_validate;miRTarBase;miRNATAP -0.16629341994918 2.46933773961822e-06 24037531 Androgen receptor and microRNA 21 axis downregulates transforming growth factor beta receptor II TGFBR2 expression in prostate cancer; Our results revealed that miR-21 suppresses TGFBR2 levels by binding to its 3'-UTR and AR signaling further potentiates this effect in both untransformed and transformed human prostate epithelial cells as well as in human prostate cancers; Manipulation of androgen signaling or the expression levels of AR or miR-21 negatively altered TGFBR2 expression in untransformed and transformed human prostate epithelial cells human prostate cancer xenografts and mouse prostate glands; Together these results suggest that the AR and miR-21 axis exerts its oncogenic effects in prostate tumors by downregulating TGFBR2 hence inhibiting the tumor-suppressive activity of TGFβ pathway prostate cancer hsa-miR-590-3p TGFBR2 1.13702599385212 3.53435739887793e-22 -0.392800266100506 0.000685075520210389 miRanda -0.227093418005756 7.99092099509756e-06 NA NA NA hsa-miR-590-5p TGFBR2 0.709763558412506 1.11883921359361e-11 -0.392800266100506 0.000685075520210389 miRNAWalker2_validate;miRTarBase;PITA;miRanda;miRNATAP -0.231380291088817 9.82241155278765e-05 NA NA NA hsa-miR-93-5p TGFBR2 1.37365940377595 2.37567548683245e-46 -0.392800266100506 0.000685075520210389 miRNAWalker2_validate;miRNATAP -0.168687997812164 0.00362979330118336 NA NA NA hsa-miR-10a-5p TP73 -1.17164272592931 4.86621098042279e-24 2.90482793390059 4.39014240218466e-38 mirMAP -1.11411384882646 9.03658690425379e-27 NA NA NA hsa-miR-10b-5p TP73 -0.89971464210447 1.18190532299934e-20 2.90482793390059 4.39014240218466e-38 mirMAP -1.22295650247371 2.39075931723443e-21 NA NA NA hsa-miR-127-5p TP73 -1.33574359249785 5.73079880594981e-13 2.90482793390059 4.39014240218466e-38 mirMAP -0.264991994884547 0.000257118275902226 NA NA NA hsa-miR-149-5p TP73 -1.95790336710741 8.46371715052367e-27 2.90482793390059 4.39014240218466e-38 mirMAP -0.394074628819457 1.33235842195455e-08 NA NA NA hsa-miR-200b-3p TP73 -1.70383252137161 2.38979336321755e-30 2.90482793390059 4.39014240218466e-38 MirTarget;TargetScan -0.60341487622118 3.15822472060177e-13 23389960 Down regulation of miR 200b 3p by low p73 contributes to the androgen independence of prostate cancer cells; In this study we investigated the role that the interaction between miR-200b-3p and p73 plays in the proliferation of AIPC; Then we examined the effect of p73 and miR-200b-3p on the proliferation of AIPC and ADPC using CCK-8; Furthermore we investigated the regulation of miR-200b-3p by p73 prostate cancer hsa-miR-200c-3p TP73 -5.40303134829523 2.74173143360645e-94 2.90482793390059 4.39014240218466e-38 MirTarget;miRNATAP -0.409492957865582 5.8895442712993e-29 NA NA NA hsa-miR-204-5p TP73 -1.67490789640238 9.14741888352476e-10 2.90482793390059 4.39014240218466e-38 mirMAP -0.19132980141488 0.000112040317786524 NA NA NA hsa-miR-335-5p TP73 -2.09515619961552 1.03765771499548e-25 2.90482793390059 4.39014240218466e-38 mirMAP -0.307690920833149 1.92394444058327e-06 NA NA NA hsa-miR-429 TP73 -2.16569233119434 2.66862243626443e-37 2.90482793390059 4.39014240218466e-38 MirTarget;miRNATAP -0.506233856445993 1.05240755394983e-12 NA NA NA hsa-miR-19a-3p WNT10A 0.722913586880779 2.76301458932381e-10 -1.83582410360244 5.71954036521957e-15 MirTarget -0.335473652738679 0.00366687468356684 NA NA NA hsa-miR-361-3p WNT10A 1.08992546227594 1.13197240706704e-36 -1.83582410360244 5.71954036521957e-15 MirTarget -0.473128812880961 0.000785717692609658 NA NA NA hsa-miR-378a-3p WNT10A 0.287244802401236 0.0501155019984562 -1.83582410360244 5.71954036521957e-15 MirTarget;miRNATAP -0.370442926187425 5.53465686980862e-05 NA NA NA hsa-miR-378c WNT10A 0.755048315231594 3.56147090439556e-06 -1.83582410360244 5.71954036521957e-15 MirTarget;miRNATAP -0.383544069159523 2.83864417632493e-06 NA NA NA hsa-miR-188-5p WNT10B -1.74586655806628 1.50431624674552e-28 2.11831281650398 3.35530016234749e-17 PITA -0.34990711525005 5.72353747736967e-05 NA NA NA hsa-miR-335-5p WNT10B -2.09515619961552 1.03765771499548e-25 2.11831281650398 3.35530016234749e-17 miRNAWalker2_validate -0.244912142870209 0.000303856113346857 NA NA NA hsa-miR-330-3p WNT11 0.912906550436308 3.35037014057665e-13 -2.12120372736476 9.81409313994183e-17 miRNATAP -0.469777058916167 4.94223139272272e-05 NA NA NA hsa-miR-590-3p WNT11 1.13702599385212 3.53435739887793e-22 -2.12120372736476 9.81409313994183e-17 miRanda -0.578179908588024 7.69555081701839e-07 NA NA NA hsa-miR-181a-5p WNT2 1.11111114875339 3.97880443756442e-29 -2.96293208145639 2.47869288523431e-21 miRNAWalker2_validate -1.28470937584115 4.07007441763254e-15 NA NA NA hsa-miR-361-3p WNT2 1.08992546227594 1.13197240706704e-36 -2.96293208145639 2.47869288523431e-21 MirTarget -1.05495281656866 2.17235731910829e-08 NA NA NA hsa-miR-590-3p WNT2 1.13702599385212 3.53435739887793e-22 -2.96293208145639 2.47869288523431e-21 miRanda;mirMAP -0.686723311303017 2.40384279467165e-06 NA NA NA hsa-miR-107 WNT4 0.140046250553248 0.0943611632552367 -2.55367361567085 1.52308888223493e-23 PITA;miRNATAP -0.56828330648821 0.00187197661596264 NA NA NA hsa-miR-126-5p WNT5A 0.785607261431085 5.77058629454465e-13 -1.25649996580397 2.97982315334721e-13 mirMAP -0.497609550494676 7.01940069035601e-09 NA NA NA hsa-miR-140-3p WNT5A 0.989350547007025 6.14964028267239e-25 -1.25649996580397 2.97982315334721e-13 MirTarget;miRNATAP -0.410982799593669 1.53927981205954e-05 NA NA NA hsa-miR-144-5p WNT5A 1.47329317992706 4.31620137156824e-12 -1.25649996580397 2.97982315334721e-13 mirMAP -0.181231886000792 4.64255738631183e-05 NA NA NA hsa-miR-155-5p WNT5A 3.26274490570809 5.06841441826518e-51 -1.25649996580397 2.97982315334721e-13 miRNAWalker2_validate;mirMAP -0.111728607814617 0.00384447853284572 NA NA NA hsa-miR-16-5p WNT5A 0.934012514027655 4.85417898318515e-24 -1.25649996580397 2.97982315334721e-13 miRNAWalker2_validate -0.292442381918752 0.00341475986146058 NA NA NA hsa-miR-195-3p WNT5A 0.808592887366705 6.8151241038711e-09 -1.25649996580397 2.97982315334721e-13 MirTarget;mirMAP;miRNATAP -0.237857210411741 0.000625989364005096 NA NA NA hsa-miR-374b-5p WNT5A 0.0804104684417872 0.365593963035077 -1.25649996580397 2.97982315334721e-13 MirTarget;miRNATAP -0.306774236271591 0.00629832209619688 NA NA NA hsa-miR-455-5p WNT5A 0.773674551205946 2.12957541541474e-09 -1.25649996580397 2.97982315334721e-13 miRanda -0.326532956746668 1.02604153763706e-05 NA NA NA hsa-miR-590-3p WNT5A 1.13702599385212 3.53435739887793e-22 -1.25649996580397 2.97982315334721e-13 miRanda;mirMAP;miRNATAP -0.245049075980974 0.00188051767367072 NA NA NA hsa-miR-9-5p WNT6 -2.23538606210968 1.28143998950751e-12 0.573762768732148 0.00965335988594974 miRNAWalker2_validate -0.110784388738162 0.00310707690872659 NA NA NA hsa-miR-103a-3p WNT7A 0.779373475434461 7.37867196796994e-20 -4.41166816287719 1.36878717328109e-55 MirTarget -1.19405957803875 2.93529853002323e-09 NA NA NA hsa-miR-107 WNT7A 0.140046250553248 0.0943611632552367 -4.41166816287719 1.36878717328109e-55 MirTarget;miRanda -0.635774495658721 0.00436175077900126 NA NA NA hsa-miR-15a-5p WNT7A 1.42663930007845 1.36006952074963e-57 -4.41166816287719 1.36878717328109e-55 MirTarget -1.82815418801503 8.42016646493443e-31 NA NA NA hsa-miR-15b-5p WNT7A 0.773001494057531 1.71784656078957e-16 -4.41166816287719 1.36878717328109e-55 MirTarget -0.95225124568654 3.17065762018165e-07 27195958 WNT7A Regulation by miR 15b in Ovarian Cancer; In the present study we report that WNT7A is a direct target of miR-15b in ovarian cancer; We showed that a luciferase reporter containing the putative binding site of miR-15b in the WNT7A 3'-UTR was significantly repressed by miR-15b; Mutation of the putative binding site of miR-15b in the WNT7A 3'-UTR restored luciferase activity; Furthermore miR-15b was able to repress increased levels of TOPFLASH activity by WNT7A but not those induced by S33Y; Additionally miR-15b dose-dependently decreased WNT7A expression; When we evaluated the prognostic impact of WNT7A and miR-15b expression using TCGA datasets a significant inverse correlation in which high-expression of WNT7A and low-expression of miR-15b was associated with reduced survival rates of ovarian cancer patients; These results suggest that WNT7A is post-transcriptionally regulated by miR-15b which could be down-regulated by promoter hypermethylation potentially via DNMT1 in ovarian cancer poor survival ovarian cancer hsa-miR-16-5p WNT7A 0.934012514027655 4.85417898318515e-24 -4.41166816287719 1.36878717328109e-55 MirTarget -1.37552144473489 2.14582516810069e-14 NA NA NA hsa-miR-224-5p WNT7A 2.84654230414912 3.0480927226395e-47 -4.41166816287719 1.36878717328109e-55 mirMAP -0.756552608402768 8.37037832335284e-24 NA NA NA hsa-miR-374a-3p WNT7A 1.13863935833993 2.79089304015401e-44 -4.41166816287719 1.36878717328109e-55 MirTarget -1.54923790932129 3.58606117705574e-16 NA NA NA hsa-miR-590-3p WNT7A 1.13702599385212 3.53435739887793e-22 -4.41166816287719 1.36878717328109e-55 miRanda -0.92795717032378 1.16187249549145e-10 NA NA NA hsa-miR-592 WNT7A 2.6404220268798 8.81369998128794e-32 -4.41166816287719 1.36878717328109e-55 mirMAP -0.609812603211465 9.69360466921476e-18 NA NA NA hsa-miR-106b-5p WNT7B 1.07509411417907 2.11739194181878e-36 -4.8472421200918 2.43699458537499e-37 mirMAP -1.70326069550996 1.42656486953374e-12 NA NA NA hsa-miR-185-3p WNT7B 0.993379985307475 2.62011454953707e-13 -4.8472421200918 2.43699458537499e-37 mirMAP -0.602968297688633 0.000363506579853172 NA NA NA hsa-miR-330-5p WNT7B 1.44960468659754 2.12131210588035e-45 -4.8472421200918 2.43699458537499e-37 MirTarget;miRanda -1.53270396237407 1.36587050977043e-15 NA NA NA hsa-miR-34a-5p WNT7B 1.07544567720768 1.81510842038009e-20 -4.8472421200918 2.43699458537499e-37 mirMAP -0.658371786662558 0.000569093576396457 NA NA NA hsa-miR-542-3p WNT7B 0.431147917094433 0.000254981247606435 -4.8472421200918 2.43699458537499e-37 mirMAP -0.72576979545906 0.000250997120479415 NA NA NA hsa-miR-320a WNT8B 0.412740558379182 2.02929519701706e-05 -3.82146976752756 1.32105284501703e-51 miRanda -0.71729018598612 1.8385618600578e-05 NA NA NA hsa-miR-17-5p WNT9B 0.494260110870015 3.8348005261e-09 -4.46182424765011 9.94801880083936e-57 TargetScan -1.27999508650342 2.01305065024565e-09 NA NA NA hsa-miR-340-5p WNT9B 1.14479851941741 2.91936881701444e-15 -4.46182424765011 9.94801880083936e-57 mirMAP -0.834276192054844 2.05689589410603e-12 NA NA NA hsa-miR-590-3p WNT9B 1.13702599385212 3.53435739887793e-22 -4.46182424765011 9.94801880083936e-57 miRanda -1.4425596042741 8.97725605112781e-26 NA NA NA hsa-miR-590-5p WNT9B 0.709763558412506 1.11883921359361e-11 -4.46182424765011 9.94801880083936e-57 miRanda -1.21816926991661 2.83884427316911e-13 NA NA NA hsa-miR-942-5p WNT9B 0.978672610596303 3.12802933163696e-12 -4.46182424765011 9.94801880083936e-57 MirTarget -0.798629955626619 1.62476231126677e-10 NA NA NA hsa-miR-103a-3p WTIP 0.779373475434461 7.37867196796994e-20 -0.707213778343433 1.03480010401706e-06 mirMAP -0.262377573132246 0.00361932081971786 NA NA NA hsa-miR-106b-5p WTIP 1.07509411417907 2.11739194181878e-36 -0.707213778343433 1.03480010401706e-06 mirMAP -0.240425256162111 0.0049164081257596 NA NA NA hsa-miR-146b-3p WTIP 1.20941495066078 2.12939149602665e-10 -0.707213778343433 1.03480010401706e-06 mirMAP -0.120965972220546 0.00345169034312444 NA NA NA hsa-miR-148b-5p WTIP 0.269550343699955 0.0383631776794927 -0.707213778343433 1.03480010401706e-06 mirMAP -0.171122039101204 0.00791341282684169 NA NA NA hsa-miR-15a-5p WTIP 1.42663930007845 1.36006952074963e-57 -0.707213778343433 1.03480010401706e-06 mirMAP -0.343407573103235 5.62755523829841e-06 NA NA NA hsa-miR-15b-5p WTIP 0.773001494057531 1.71784656078957e-16 -0.707213778343433 1.03480010401706e-06 mirMAP -0.324084070453577 8.49012313171861e-05 NA NA NA hsa-miR-16-5p WTIP 0.934012514027655 4.85417898318515e-24 -0.707213778343433 1.03480010401706e-06 mirMAP -0.353709723364751 1.40932439052711e-05 NA NA NA hsa-miR-181b-5p WTIP 1.49054296272357 3.69051660739368e-41 -0.707213778343433 1.03480010401706e-06 mirMAP -0.205860616076657 0.00137840372401982 NA NA NA hsa-miR-185-5p WTIP 1.05056378692621 1.31174187880682e-22 -0.707213778343433 1.03480010401706e-06 mirMAP -0.382051582683131 4.07106138215448e-08 NA NA NA hsa-miR-186-5p WTIP 0.507217561043443 9.04455748270995e-10 -0.707213778343433 1.03480010401706e-06 mirMAP -0.423581529687181 9.34123997516361e-06 NA NA NA hsa-miR-192-3p WTIP 0.156650099616707 0.483496040900362 -0.707213778343433 1.03480010401706e-06 mirMAP -0.124840339927927 0.000605714791945417 NA NA NA hsa-miR-193b-3p WTIP -0.273325765316079 0.104328826585392 -0.707213778343433 1.03480010401706e-06 mirMAP -0.140390374521904 0.00358201954792136 NA NA NA hsa-miR-193b-5p WTIP 0.277625648727715 0.101981573602756 -0.707213778343433 1.03480010401706e-06 mirMAP -0.238285214092217 6.51160791127118e-07 NA NA NA hsa-miR-194-5p WTIP 0.62222617402691 0.00659826803316099 -0.707213778343433 1.03480010401706e-06 mirMAP -0.150239326415482 1.72389644462093e-05 NA NA NA hsa-miR-22-3p WTIP 0.198460552200729 0.00761005672059428 -0.707213778343433 1.03480010401706e-06 mirMAP -0.480888453096833 1.09900325232753e-05 NA NA NA hsa-miR-2355-5p WTIP 1.57515081110162 3.54962327490702e-48 -0.707213778343433 1.03480010401706e-06 mirMAP -0.221112629928765 0.000617597519065429 NA NA NA hsa-miR-25-3p WTIP 1.12016166564779 3.79069348635778e-48 -0.707213778343433 1.03480010401706e-06 mirMAP -0.37717222200676 3.38526064877549e-05 NA NA NA hsa-miR-29b-3p WTIP -0.228125979913806 0.0271621721891603 -0.707213778343433 1.03480010401706e-06 mirMAP -0.366782364550413 2.60863205180791e-06 NA NA NA hsa-miR-330-5p WTIP 1.44960468659754 2.12131210588035e-45 -0.707213778343433 1.03480010401706e-06 mirMAP -0.321574237689349 2.36579285472757e-06 NA NA NA hsa-miR-331-3p WTIP 0.431607034018882 6.83022920590941e-05 -0.707213778343433 1.03480010401706e-06 mirMAP -0.285111420541782 0.000118769961704312 NA NA NA hsa-miR-342-5p WTIP 1.37011183051517 4.99462376051624e-28 -0.707213778343433 1.03480010401706e-06 mirMAP -0.240335500866982 5.083694060107e-05 NA NA NA hsa-miR-34a-5p WTIP 1.07544567720768 1.81510842038009e-20 -0.707213778343433 1.03480010401706e-06 mirMAP -0.212176524071463 0.00126826535342348 NA NA NA hsa-miR-361-3p WTIP 1.08992546227594 1.13197240706704e-36 -0.707213778343433 1.03480010401706e-06 mirMAP -0.455087274504698 4.41268992537281e-08 NA NA NA hsa-miR-365a-3p WTIP 0.80809616164259 2.36039522526e-12 -0.707213778343433 1.03480010401706e-06 mirMAP -0.210300022857083 0.0020258449955143 NA NA NA hsa-miR-484 WTIP 0.571987778099603 9.67278224458421e-10 -0.707213778343433 1.03480010401706e-06 mirMAP -0.258328037705043 0.00238246328241901 NA NA NA hsa-miR-589-5p WTIP 0.696241532021631 5.26958362886071e-16 -0.707213778343433 1.03480010401706e-06 mirMAP -0.581609662533615 4.94779479457462e-11 NA NA NA hsa-miR-625-5p WTIP 0.153090549230629 0.330314026509869 -0.707213778343433 1.03480010401706e-06 mirMAP -0.159204310355569 0.00446979990663344 NA NA NA hsa-let-7f-1-3p WWC1 0.477913872379336 4.46669616865068e-05 -0.993995746920417 8.32216427262761e-18 MirTarget -0.181957369781173 0.00321684217448911 NA NA NA hsa-miR-106b-5p WWC1 1.07509411417907 2.11739194181878e-36 -0.993995746920417 8.32216427262761e-18 mirMAP -0.533788785963453 4.27982955145991e-15 NA NA NA hsa-miR-130b-3p WWC1 1.12788913578446 2.939369462276e-16 -0.993995746920417 8.32216427262761e-18 mirMAP -0.40179741926181 7.19585601742922e-20 NA NA NA hsa-miR-143-5p WWC1 0.297037599500085 0.0442949119420742 -0.993995746920417 8.32216427262761e-18 mirMAP -0.142668574565401 0.00170412123768612 NA NA NA hsa-miR-150-5p WWC1 1.00371863159681 1.09871676395528e-09 -0.993995746920417 8.32216427262761e-18 mirMAP -0.210508996849399 7.60039395323738e-08 NA NA NA hsa-miR-155-5p WWC1 3.26274490570809 5.06841441826518e-51 -0.993995746920417 8.32216427262761e-18 miRNAWalker2_validate;MirTarget;miRNATAP -0.221079618131914 8.6173190212322e-19 NA NA NA hsa-miR-15a-5p WWC1 1.42663930007845 1.36006952074963e-57 -0.993995746920417 8.32216427262761e-18 MirTarget;miRNATAP -0.467570860808223 1.6276992407411e-14 NA NA NA hsa-miR-15b-5p WWC1 0.773001494057531 1.71784656078957e-16 -0.993995746920417 8.32216427262761e-18 MirTarget;miRNATAP -0.381822443729144 1.53783503948627e-08 NA NA NA hsa-miR-16-5p WWC1 0.934012514027655 4.85417898318515e-24 -0.993995746920417 8.32216427262761e-18 MirTarget;miRNATAP -0.395633806263311 2.96936785979494e-09 NA NA NA hsa-miR-17-5p WWC1 0.494260110870015 3.8348005261e-09 -0.993995746920417 8.32216427262761e-18 mirMAP -0.413534667882655 1.07137901062901e-07 NA NA NA hsa-miR-195-5p WWC1 0.346502644882604 0.0092562828415903 -0.993995746920417 8.32216427262761e-18 MirTarget;miRNATAP -0.141733142661729 0.0049734115897166 NA NA NA hsa-miR-20a-5p WWC1 0.702602695798242 4.06372887613329e-13 -0.993995746920417 8.32216427262761e-18 mirMAP -0.36702745484488 2.86349549082414e-08 NA NA NA hsa-miR-28-5p WWC1 0.461962042257226 3.32424690573327e-11 -0.993995746920417 8.32216427262761e-18 mirMAP -0.34059334274429 0.000323851637858034 NA NA NA hsa-miR-32-5p WWC1 0.407826130035097 7.26884631998646e-06 -0.993995746920417 8.32216427262761e-18 miRNATAP -0.238944639823486 0.00114260420415934 NA NA NA hsa-miR-330-5p WWC1 1.44960468659754 2.12131210588035e-45 -0.993995746920417 8.32216427262761e-18 miRanda -0.464725711940659 1.23450363637822e-17 NA NA NA hsa-miR-423-5p WWC1 0.250929012519631 0.00288495915028486 -0.993995746920417 8.32216427262761e-18 miRNATAP -0.25018333706095 0.00181455850289713 NA NA NA hsa-miR-454-3p WWC1 0.68285296887698 1.17407812677787e-08 -0.993995746920417 8.32216427262761e-18 mirMAP -0.267955961236679 8.44643890048158e-07 NA NA NA hsa-miR-92a-3p WWC1 0.178194888895831 0.0088835082650834 -0.993995746920417 8.32216427262761e-18 miRNATAP -0.44147181612248 8.80265837119232e-06 NA NA NA hsa-miR-92b-3p WWC1 0.418630595140165 6.50466149211154e-05 -0.993995746920417 8.32216427262761e-18 miRNATAP -0.266937580308912 2.5358810596142e-05 NA NA NA hsa-miR-93-5p WWC1 1.37365940377595 2.37567548683245e-46 -0.993995746920417 8.32216427262761e-18 mirMAP -0.46166854087752 2.44013853370053e-15 NA NA NA hsa-miR-18a-5p WWTR1 0.936704393213466 1.05064580570579e-10 0.0536513642454208 0.600963465880977 miRNAWalker2_validate -0.162041818182554 1.54786468454239e-05 NA NA NA hsa-miR-193b-3p WWTR1 -0.273325765316079 0.104328826585392 0.0536513642454208 0.600963465880977 miRNAWalker2_validate -0.205030745977848 3.72684998833731e-10 NA NA NA hsa-miR-29a-3p WWTR1 -0.431613225927952 4.10166815070288e-08 0.0536513642454208 0.600963465880977 miRNATAP -0.365287795012884 1.82883102191483e-07 NA NA NA hsa-miR-29b-3p WWTR1 -0.228125979913806 0.0271621721891603 0.0536513642454208 0.600963465880977 miRNATAP -0.295382597589229 4.31546940936371e-08 NA NA NA hsa-miR-29c-3p WWTR1 -0.238671318446745 0.0141475322347596 0.0536513642454208 0.600963465880977 miRNATAP -0.204991668751564 0.000412084456777229 NA NA NA hsa-miR-30b-5p WWTR1 -1.18330589477119 6.8341618466966e-27 0.0536513642454208 0.600963465880977 MirTarget;mirMAP -0.228201597561434 1.01657244442326e-06 NA NA NA hsa-miR-374b-5p WWTR1 0.0804104684417872 0.365593963035077 0.0536513642454208 0.600963465880977 MirTarget;mirMAP -0.202095886387947 0.00159991338137789 NA NA NA hsa-miR-3913-5p WWTR1 0.136365354811444 0.24239516424369 0.0536513642454208 0.600963465880977 mirMAP -0.142445898435338 0.00527264998540573 NA NA NA hsa-miR-501-5p WWTR1 -1.1103073934745 1.81589804886553e-16 0.0536513642454208 0.600963465880977 mirMAP -0.202759537559765 2.53465829388033e-07 NA NA NA hsa-miR-590-3p WWTR1 1.13702599385212 3.53435739887793e-22 0.0536513642454208 0.600963465880977 MirTarget;miRanda;mirMAP -0.125192687897365 0.00551417407442718 NA NA NA hsa-miR-651-5p WWTR1 0.535144061895781 2.49922577209869e-05 0.0536513642454208 0.600963465880977 MirTarget -0.146728712359851 0.0016793364127649 NA NA NA hsa-let-7a-3p YAP1 0.0677487960013088 0.460458477653989 -0.569347735319695 1.77457500633277e-16 mirMAP -0.209262458101024 1.42568046601879e-06 NA NA NA hsa-let-7f-1-3p YAP1 0.477913872379336 4.46669616865068e-05 -0.569347735319695 1.77457500633277e-16 mirMAP -0.143936592398417 7.86775590489703e-05 NA NA NA hsa-miR-142-5p YAP1 1.88417391525707 1.2096808039882e-27 -0.569347735319695 1.77457500633277e-16 mirMAP -0.141022901961815 6.74116495396044e-12 NA NA NA hsa-miR-16-2-3p YAP1 1.3046118743965 4.17207934608428e-19 -0.569347735319695 1.77457500633277e-16 mirMAP -0.121928527741888 1.77746127864476e-06 NA NA NA hsa-miR-186-5p YAP1 0.507217561043443 9.04455748270995e-10 -0.569347735319695 1.77457500633277e-16 MirTarget -0.136842563721548 0.00390490976815093 27073580 We observed that miR-186 was downregulated in several HCC cell lines and that it directly targets YAP1 mRNA; Overexpression of miR-186 in HCC cells significantly downregulates YAP1 mRNA and protein levels leading to downregulation of the Hippo signaling pathway which in turn severely inhibits HCC cell migration invasion and proliferation; Our study is the first to report the direct involvement of miR-186 in downregulating YAP1 and more significantly inhibiting HCC tumorigenesis and supports the role miR-186 as a potential therapeutic target in treating liver cancer cell migration;tumorigenesis liver cancer hsa-miR-21-5p YAP1 2.51462371613332 3.30620591950316e-66 -0.569347735319695 1.77457500633277e-16 MirTarget;miRNATAP -0.149887355443961 3.2404583876246e-12 NA NA NA hsa-miR-361-3p YAP1 1.08992546227594 1.13197240706704e-36 -0.569347735319695 1.77457500633277e-16 MirTarget;PITA -0.266703976308752 4.44412009664076e-11 NA NA NA hsa-miR-361-5p YAP1 0.0514169367202078 0.382929376393199 -0.569347735319695 1.77457500633277e-16 miRanda -0.327420787743164 1.95158167312761e-06 NA NA NA hsa-miR-455-5p YAP1 0.773674551205946 2.12957541541474e-09 -0.569347735319695 1.77457500633277e-16 miRanda -0.199848088194878 9.28109499121111e-12 NA NA NA hsa-miR-484 YAP1 0.571987778099603 9.67278224458421e-10 -0.569347735319695 1.77457500633277e-16 PITA;miRNATAP -0.173615540323587 2.95130206848509e-05 NA NA NA hsa-miR-590-3p YAP1 1.13702599385212 3.53435739887793e-22 -0.569347735319695 1.77457500633277e-16 miRanda;mirMAP -0.186221129795157 2.52651369251181e-09 NA NA NA hsa-miR-590-5p YAP1 0.709763558412506 1.11883921359361e-11 -0.569347735319695 1.77457500633277e-16 MirTarget;PITA;miRanda;miRNATAP -0.191515043792203 1.66034420533093e-07 NA NA NA hsa-miR-616-5p YAP1 0.913426384742148 3.78418389333709e-09 -0.569347735319695 1.77457500633277e-16 mirMAP -0.106828924306124 2.55200024481593e-05 NA NA NA hsa-miR-625-5p YAP1 0.153090549230629 0.330314026509869 -0.569347735319695 1.77457500633277e-16 MirTarget -0.10466703685979 0.000133990806911464 NA NA NA hsa-miR-181a-5p YWHAB 1.11111114875339 3.97880443756442e-29 -0.436649879556757 1.07574819649047e-17 mirMAP -0.157430815606491 3.72850286786433e-09 NA NA NA hsa-miR-181b-5p YWHAB 1.49054296272357 3.69051660739368e-41 -0.436649879556757 1.07574819649047e-17 mirMAP -0.148555433994048 7.04256501112272e-11 NA NA NA hsa-miR-27a-3p YWHAB 0.558934437526245 1.44256383086177e-12 -0.436649879556757 1.07574819649047e-17 MirTarget;miRNATAP -0.140096204677841 0.000109347058006503 NA NA NA hsa-miR-28-3p YWHAB 1.01277915413238 1.8655970171461e-43 -0.436649879556757 1.07574819649047e-17 mirMAP -0.128268747523935 0.000279381491821486 NA NA NA hsa-miR-590-3p YWHAB 1.13702599385212 3.53435739887793e-22 -0.436649879556757 1.07574819649047e-17 miRanda -0.114186720944627 9.10728186010718e-07 NA NA NA hsa-miR-140-5p YWHAE 0.504309496243674 3.09884038729031e-11 -0.126291713961324 0.00146652744659035 miRanda -0.147589734050215 9.44106228586763e-08 NA NA NA hsa-miR-200a-3p YWHAG -1.43409013664263 2.00188483717828e-20 0.356795537472197 2.99065123952189e-09 MirTarget;miRNATAP -0.108146282995436 8.88223977768603e-08 NA NA NA hsa-miR-200b-3p YWHAG -1.70383252137161 2.38979336321755e-30 0.356795537472197 2.99065123952189e-09 MirTarget;TargetScan -0.109950840688747 6.60623803058959e-08 NA NA NA hsa-miR-23b-3p YWHAG -0.533749586990474 2.46924776953771e-10 0.356795537472197 2.99065123952189e-09 MirTarget;miRNATAP -0.125114895596028 0.00146198575052877 NA NA NA hsa-miR-30a-5p YWHAG -0.778411951775343 2.73322451127932e-16 0.356795537472197 2.99065123952189e-09 miRNATAP -0.244666106319673 1.06273731298785e-13 NA NA NA hsa-miR-30b-5p YWHAG -1.18330589477119 6.8341618466966e-27 0.356795537472197 2.99065123952189e-09 miRNATAP -0.153808500618617 3.37747961935545e-08 NA NA NA hsa-miR-30c-5p YWHAG -1.08783070774238 2.02505402525786e-24 0.356795537472197 2.99065123952189e-09 miRNATAP -0.136382262402707 3.07275349224244e-06 NA NA NA hsa-miR-429 YWHAG -2.16569233119434 2.66862243626443e-37 0.356795537472197 2.99065123952189e-09 MirTarget;PITA;miRanda;miRNATAP -0.103261950591647 2.69299283602683e-09 NA NA NA hsa-miR-324-5p YWHAH -0.487750893426456 3.74472736457965e-05 0.879541909818469 2.70172159291526e-40 miRNAWalker2_validate -0.10780707564178 0.0018544112120671 NA NA NA hsa-miR-33a-5p YWHAH -1.59840463890997 1.13487952314403e-18 0.879541909818469 2.70172159291526e-40 miRNAWalker2_validate;MirTarget;miRNATAP -0.12503282006823 3.8785311230509e-09 NA NA NA hsa-miR-508-3p YWHAH -3.41433288024917 3.47699261121175e-37 0.879541909818469 2.70172159291526e-40 miRNATAP -0.129480004616491 4.79117076373846e-24 NA NA NA hsa-miR-30a-5p YWHAZ -0.778411951775343 2.73322451127932e-16 0.131743827589666 0.0169925785623515 miRNAWalker2_validate;MirTarget;miRNATAP -0.155632407992389 2.42076268396331e-07 NA NA NA hsa-miR-30d-5p YWHAZ -0.202727675788184 0.00659067084745794 0.131743827589666 0.0169925785623515 MirTarget;miRNATAP -0.113720265182448 0.00562868472799409 NA NA NA hsa-miR-361-5p YWHAZ 0.0514169367202078 0.382929376393199 0.131743827589666 0.0169925785623515 miRanda -0.15008979606015 0.00451477624517307 NA NA NA