miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7a-5p AKT2 -1.37014061604018 3.11451492971224e-14 0.158500088541505 0.113504798741429 TargetScan -0.119930037553526 1.13227688326527e-06 NA NA NA hsa-miR-29a-3p AKT2 0.101650412194573 0.573201097011668 0.158500088541505 0.113504798741429 MirTarget -0.104368014677354 4.26511869332683e-05 24076586 Furthermore a feed-back loop comprising of c-Myc miR-29 family and Akt2 were found in myeloid leukemogenesis acute myeloid leukemia hsa-miR-106b-5p AKT3 1.47447672652218 1.32004094930462e-13 -1.44031241124732 2.576504600149e-09 miRNATAP -0.158920731526324 0.00425859940487133 NA NA NA hsa-miR-107 AKT3 0.658676029898313 5.11480446318819e-07 -1.44031241124732 2.576504600149e-09 PITA;miRanda -0.256548300142307 0.00309702957622585 NA NA NA hsa-miR-146b-5p AKT3 1.0922867893808 5.63754607494775e-06 -1.44031241124732 2.576504600149e-09 miRNAWalker2_validate -0.14508398550335 0.00188822517544197 NA NA NA hsa-miR-15a-5p AKT3 1.62575353599172 1.55312121019827e-19 -1.44031241124732 2.576504600149e-09 miRNAWalker2_validate;miRTarBase;miRNATAP -0.412918804091755 4.08840965026726e-12 NA NA NA hsa-miR-16-5p AKT3 0.749619098384047 4.11649450706988e-06 -1.44031241124732 2.576504600149e-09 miRNAWalker2_validate;miRTarBase;miRNATAP -0.269698520974258 9.94440318719177e-05 NA NA NA hsa-miR-17-5p AKT3 2.07078488653279 2.77403038572568e-19 -1.44031241124732 2.576504600149e-09 TargetScan;miRNATAP -0.217476886844258 3.56953935954486e-06 NA NA NA hsa-miR-181a-5p AKT3 -0.375429731222937 0.0562142867129802 -1.44031241124732 2.576504600149e-09 miRNATAP -0.22550600060725 9.19470016250579e-05 NA NA NA hsa-miR-181b-5p AKT3 0.668793269169928 0.000239998092406404 -1.44031241124732 2.576504600149e-09 miRNATAP -0.367498754199467 2.09865276667175e-09 NA NA NA hsa-miR-20a-5p AKT3 2.64649625616975 5.1469418982085e-27 -1.44031241124732 2.576504600149e-09 miRNATAP -0.24430728120197 1.27608550819212e-08 NA NA NA hsa-miR-22-3p AKT3 1.42501909916631 1.72295005910055e-25 -1.44031241124732 2.576504600149e-09 miRNATAP -0.259390140878921 0.0010937362716222 NA NA NA hsa-miR-29b-2-5p AKT3 0.345881055247341 0.194842633194187 -1.44031241124732 2.576504600149e-09 mirMAP -0.181342398720756 1.80199534450665e-05 NA NA NA hsa-miR-29b-3p AKT3 3.10527711861309 3.01242507282711e-32 -1.44031241124732 2.576504600149e-09 miRNATAP -0.267243460090773 1.17871192498365e-11 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-3065-5p AKT3 0.653308707552535 0.0999497219778851 -1.44031241124732 2.576504600149e-09 mirMAP -0.18242132898273 2.34990243224026e-09 NA NA NA hsa-miR-362-5p AKT3 0.658947634569393 0.0243306847205756 -1.44031241124732 2.576504600149e-09 PITA;TargetScan;miRNATAP -0.229571357984291 4.43564207755877e-09 NA NA NA hsa-miR-542-3p AKT3 1.62226640768239 2.6427102465476e-10 -1.44031241124732 2.576504600149e-09 miRanda -0.186790699816246 1.44501888663791e-05 NA NA NA hsa-miR-93-5p AKT3 1.50844106515467 1.83836866996875e-12 -1.44031241124732 2.576504600149e-09 miRNATAP -0.251105283811718 1.01733106411986e-06 NA NA NA hsa-miR-141-3p CBL 3.36993755486106 5.42939251147195e-32 -0.469248650500356 0.00115520133723955 MirTarget;TargetScan;mirMAP -0.146441699849551 5.44458661328669e-12 NA NA NA hsa-miR-141-5p CBL 3.02575703771074 1.54385222591327e-32 -0.469248650500356 0.00115520133723955 mirMAP -0.145224651738782 1.44722650829197e-09 NA NA NA hsa-miR-181c-5p CBL 0.529875814537156 0.0125885822998008 -0.469248650500356 0.00115520133723955 mirMAP -0.132128719610509 2.38769039966277e-05 NA NA NA hsa-miR-200a-3p CBL 3.14766878548496 1.32850889777422e-21 -0.469248650500356 0.00115520133723955 MirTarget;mirMAP -0.129569717906258 2.41600088231723e-11 NA NA NA hsa-miR-200a-5p CBL 2.26680634475411 1.52168554660094e-17 -0.469248650500356 0.00115520133723955 mirMAP -0.110574162471083 4.10075856971092e-06 NA NA NA hsa-miR-200b-3p CBL 1.55157578247391 4.83790020897188e-09 -0.469248650500356 0.00115520133723955 MirTarget;TargetScan;mirMAP -0.120582156727833 8.82744364806495e-07 NA NA NA hsa-miR-200c-3p CBL 0.380533388300368 0.0842181838538353 -0.469248650500356 0.00115520133723955 MirTarget;mirMAP -0.172679773192041 7.88441781421068e-09 NA NA NA hsa-miR-30d-3p CBL 0.00396376345349925 0.986457040013182 -0.469248650500356 0.00115520133723955 MirTarget -0.112602488301343 0.000440507018872659 NA NA NA hsa-miR-429 CBL 2.3794516574089 1.72813419703734e-13 -0.469248650500356 0.00115520133723955 MirTarget;PITA;mirMAP;miRNATAP -0.11971171757857 2.60695750826592e-08 NA NA NA hsa-miR-664a-3p CBL 0.443077463053857 0.0214248925850984 -0.469248650500356 0.00115520133723955 mirMAP -0.106568146971784 0.00213911903751303 NA NA NA hsa-miR-98-5p CBL 1.170602085804 1.09900501665229e-08 -0.469248650500356 0.00115520133723955 MirTarget -0.126353811973598 0.000121695667651401 NA NA NA hsa-miR-30d-5p CBLB -0.920901858717441 3.50898334321668e-05 0.596309666211689 5.64057742567432e-06 MirTarget;mirMAP -0.105886454081442 9.51778831332348e-05 NA NA NA hsa-miR-106a-5p CCND1 1.3902608059488 6.07931522284525e-05 -0.295767629587253 0.255400743295204 MirTarget;miRNATAP -0.247441760563832 4.58943715400631e-11 NA NA NA hsa-miR-106b-5p CCND1 1.47447672652218 1.32004094930462e-13 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.261384817974007 7.4979419817232e-06 NA NA NA hsa-miR-142-3p CCND1 3.98476449801341 1.56256182021111e-35 -0.295767629587253 0.255400743295204 miRanda -0.119299030581201 0.000532277158339159 23619912 Transfection of miR-142-3p mimics in colon cancer cells downregulated cyclin D1 expression induced G1 phase cell cycle arrest and elevated the sensitivity of the cells to 5-fluorouracil colon cancer hsa-miR-15a-5p CCND1 1.62575353599172 1.55312121019827e-19 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.199069637483131 0.0019294787514794 22922827 CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR sarcoma hsa-miR-15b-5p CCND1 -1.25935038177398 1.83460220856901e-12 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.303824360423629 3.25741318048184e-06 NA NA NA hsa-miR-16-1-3p CCND1 1.50034693398929 6.63958242991125e-10 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase -0.249107447749185 3.23141967346606e-05 22922827;18483394 CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR;Truncation in CCND1 mRNA alters miR 16 1 regulation in mantle cell lymphoma; Furthermore we demonstrated that this truncation alters miR-16-1 binding sites and through the use of reporter constructs we were able to show that miR-16-1 regulates CCND1 mRNA expression; This study introduces the role of miR-16-1 in the regulation of CCND1 in MCL ; sarcoma;lymphoma hsa-miR-16-5p CCND1 0.749619098384047 4.11649450706988e-06 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.371885624299403 3.21606546730418e-07 23991964;22922827;18483394 At the molecular level our results further revealed that cyclin D1 expression was negatively regulated by miR-16;CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR;Truncation in CCND1 mRNA alters miR 16 1 regulation in mantle cell lymphoma; Furthermore we demonstrated that this truncation alters miR-16-1 binding sites and through the use of reporter constructs we were able to show that miR-16-1 regulates CCND1 mRNA expression; This study introduces the role of miR-16-1 in the regulation of CCND1 in MCL ;; bladder cancer;sarcoma;lymphoma hsa-miR-17-5p CCND1 2.07078488653279 2.77403038572568e-19 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;MirTarget;TargetScan;miRNATAP -0.313758634258834 1.59321495552009e-10 26431674 Bioinformatics Prediction and In Vitro Analysis Revealed That miR 17 Targets Cyclin D1 mRNA in Triple Negative Breast Cancer Cells; In this study using bioinformatic analyses miR-17 was selected as it targets the 3'UTR of CCND1 gene with the highest score; After lentiviral transduction of miR-17 to the target cells gene expression analysis showed decreased expression of CCND1 gene breast cancer hsa-miR-186-5p CCND1 0.852175445703945 6.88885738584309e-10 -0.295767629587253 0.255400743295204 mirMAP -0.377477028673122 1.06268066352005e-05 NA NA NA hsa-miR-193a-3p CCND1 0.549173467360291 0.0319030569365466 -0.295767629587253 0.255400743295204 MirTarget;PITA;miRanda -0.190950932146342 0.000161171890671323 NA NA NA hsa-miR-193b-3p CCND1 1.10444771306846 0.000822888533401377 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase;MirTarget -0.147999411883792 3.70620495015026e-05 27071318;20655737;20304954;21893020;26129688 MicroRNA 193b inhibits the proliferation migration and invasion of gastric cancer cells via targeting cyclin D1; Further mechanism study indicated that CCND1 was a direct target of miR-193b in GC;CCND1 and ETS1 were revealed to be regulated by miR-193b directly;MicroRNA 193b represses cell proliferation and regulates cyclin D1 in melanoma; Overexpression of miR-193b in Malme-3M cells down-regulated CCND1 mRNA and protein by > or = 50%; A luciferase reporter assay confirmed that miR-193b directly regulates CCND1 by binding to the 3'untranslated region of CCND1 mRNA; These studies indicate that miR-193b represses cell proliferation and regulates CCND1 expression and suggest that dysregulation of miR-193b may play an important role in melanoma development;In a previous study we reported that miR-193b represses cell proliferation and regulates cyclin D1 in melanoma cells suggesting that miR-193b could act as a tumor suppressor;Epigenetically altered miR 193b targets cyclin D1 in prostate cancer; It has been suggested that miR-193b targets cyclin D1 in several malignancies; Here our aim was to determine if miR-193b targets cyclin D1 in prostate cancer; Furthermore the PC cell lines 22Rv1 and VCaP which express low levels of miR-193b and high levels of CCND1 showed significant growth retardation when treated with a CDK4/6 inhibitor; In contrast the inhibitor had no effect on the growth of PC-3 and DU145 cells with high miR-193b and low CCND1 expression; Taken together our data demonstrate that miR-193b targets cyclin D1 in prostate cancer ;;;; gastric cancer;liver cancer;melanoma;melanoma;prostate cancer hsa-miR-19a-3p CCND1 2.11776595911517 7.07663078397156e-10 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase;miRNATAP -0.21539529985992 9.86203433305448e-08 25985117 Moreover miR-19a might play inhibitory roles in HCC malignancy via regulating Cyclin D1 expression liver cancer hsa-miR-19b-1-5p CCND1 1.71217036351784 3.28561659177495e-12 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase -0.301713494105536 2.89182846291565e-08 NA NA NA hsa-miR-19b-3p CCND1 2.10868505662119 5.40846613768389e-17 -0.295767629587253 0.255400743295204 miRNATAP -0.179773518063806 0.000197856717032667 NA NA NA hsa-miR-20a-5p CCND1 2.64649625616975 5.1469418982085e-27 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.237160136465301 1.84669386058676e-07 NA NA NA hsa-miR-20b-5p CCND1 1.35770573270947 0.00260808530013016 -0.295767629587253 0.255400743295204 MirTarget;miRNATAP -0.179107595068828 5.65966117118738e-11 NA NA NA hsa-miR-365a-3p CCND1 0.0132777124336201 0.953597412537431 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase -0.193166924738263 0.000234492957903034 NA NA NA hsa-miR-374a-5p CCND1 -0.197027254874826 0.298080902192861 -0.295767629587253 0.255400743295204 MirTarget -0.313785702713176 9.54081268797886e-06 27191497 microRNA 374a suppresses colon cancer progression by directly reducing CCND1 to inactivate the PI3K/AKT pathway; Furthermore luciferase reporter assays confirmed that miR-374a could directly reduce CCND1; We examined miR-374a levels by in situ hybridization and its correlation with CCND1 expression in CRC tumor tissues; High miR-374a expression with low level of CCND1 was protective factor in CRC; Together these findings indicate that miR-374a inactivates the PI3K/AKT axis by inhibiting CCND1 suppressing of colon cancer progression progression colon cancer hsa-miR-374b-5p CCND1 0.474691035780475 0.0109217471394203 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;MirTarget -0.26116225100222 0.00011561978488339 NA NA NA hsa-miR-425-5p CCND1 1.21659524959201 8.01126418494715e-09 -0.295767629587253 0.255400743295204 miRNAWalker2_validate -0.245575402525843 1.03844251357893e-05 NA NA NA hsa-miR-589-3p CCND1 1.34253876396688 1.84935927493927e-05 -0.295767629587253 0.255400743295204 MirTarget -0.130907472589194 0.000793150025378685 NA NA NA hsa-miR-590-3p CCND1 0.83851360565783 0.00129224433453587 -0.295767629587253 0.255400743295204 mirMAP -0.182941292569374 0.000856336828554768 NA NA NA hsa-miR-769-3p CCND1 0.452126659761753 0.0748150639143322 -0.295767629587253 0.255400743295204 mirMAP -0.142316943866129 0.00276805281261241 NA NA NA hsa-miR-92a-3p CCND1 -0.136362762339122 0.493412263619364 -0.295767629587253 0.255400743295204 miRNAWalker2_validate -0.337251172229938 1.62058605849004e-08 NA NA NA hsa-miR-93-5p CCND1 1.50844106515467 1.83836866996875e-12 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;MirTarget;miRNATAP -0.320397820083252 2.84014735439528e-09 NA NA NA hsa-miR-942-5p CCND1 -0.0372813055050076 0.870631058767894 -0.295767629587253 0.255400743295204 MirTarget -0.177314558661089 0.000979800060419363 NA NA NA hsa-miR-106a-5p CCND2 1.3902608059488 6.07931522284525e-05 -1.64140990579885 1.49666938681079e-12 miRNATAP -0.149132151233025 1.88464236882735e-05 NA NA NA hsa-miR-106b-5p CCND2 1.47447672652218 1.32004094930462e-13 -1.64140990579885 1.49666938681079e-12 miRNAWalker2_validate;miRTarBase;miRNATAP -0.383655587509124 2.65429916887189e-13 NA NA NA hsa-miR-130b-5p CCND2 1.53645187062942 1.10498816261505e-08 -1.64140990579885 1.49666938681079e-12 mirMAP -0.268032769997331 9.22343432530747e-12 NA NA NA hsa-miR-141-3p CCND2 3.36993755486106 5.42939251147195e-32 -1.64140990579885 1.49666938681079e-12 MirTarget;TargetScan -0.239914655059016 6.4654039095017e-12 NA NA NA hsa-miR-151a-3p CCND2 0.665271883054405 0.000281673348137154 -1.64140990579885 1.49666938681079e-12 mirMAP -0.279142680983949 2.60564778780149e-06 NA NA NA hsa-miR-15a-5p CCND2 1.62575353599172 1.55312121019827e-19 -1.64140990579885 1.49666938681079e-12 miRNAWalker2_validate;miRTarBase;miRNATAP -0.158338209854594 0.00711668272045409 NA NA NA hsa-miR-17-5p CCND2 2.07078488653279 2.77403038572568e-19 -1.64140990579885 1.49666938681079e-12 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.365048259055278 1.61934056872758e-16 NA NA NA hsa-miR-182-5p CCND2 3.21839823004635 5.13049145201115e-39 -1.64140990579885 1.49666938681079e-12 miRNAWalker2_validate;miRTarBase;miRNATAP -0.373145719566719 1.32597677460149e-21 NA NA NA hsa-miR-183-5p CCND2 2.39247234736657 3.92444525331999e-21 -1.64140990579885 1.49666938681079e-12 miRNATAP -0.410520271082553 1.11291256348519e-25 NA NA NA hsa-miR-185-5p CCND2 1.14291034858482 2.95777119743491e-13 -1.64140990579885 1.49666938681079e-12 MirTarget;miRNATAP -0.23940712387784 0.000484175543966546 NA NA NA hsa-miR-186-5p CCND2 0.852175445703945 6.88885738584309e-10 -1.64140990579885 1.49666938681079e-12 mirMAP;miRNATAP -0.357370184588874 5.14493635358813e-06 NA NA NA hsa-miR-191-5p CCND2 0.343645878547116 0.0668114086143391 -1.64140990579885 1.49666938681079e-12 MirTarget -0.19767765908675 0.000750401585158583 NA NA NA hsa-miR-19a-3p CCND2 2.11776595911517 7.07663078397156e-10 -1.64140990579885 1.49666938681079e-12 MirTarget;miRNATAP -0.167455065978335 6.56621464464812e-06 NA NA NA hsa-miR-19b-3p CCND2 2.10868505662119 5.40846613768389e-17 -1.64140990579885 1.49666938681079e-12 miRNAWalker2_validate;MirTarget;miRNATAP -0.19157786848984 1.39328108679414e-05 NA NA NA hsa-miR-200a-3p CCND2 3.14766878548496 1.32850889777422e-21 -1.64140990579885 1.49666938681079e-12 MirTarget -0.173744823500602 6.53232158053391e-08 NA NA NA hsa-miR-20a-5p CCND2 2.64649625616975 5.1469418982085e-27 -1.64140990579885 1.49666938681079e-12 miRNAWalker2_validate;miRTarBase;miRNATAP -0.28367508352758 5.6750334332974e-12 NA NA NA hsa-miR-21-3p CCND2 2.54206008030157 1.11598785398763e-30 -1.64140990579885 1.49666938681079e-12 mirMAP -0.212907340098529 4.00646631535515e-06 NA NA NA hsa-miR-2355-3p CCND2 1.10676344164715 6.24068383465151e-06 -1.64140990579885 1.49666938681079e-12 miRNATAP -0.221166273655799 1.96123873319489e-06 NA NA NA hsa-miR-28-5p CCND2 1.19639196514745 4.59365801666536e-18 -1.64140990579885 1.49666938681079e-12 miRanda -0.289410618824274 0.00017592467355866 NA NA NA hsa-miR-301a-3p CCND2 2.70198002906399 1.56420889710984e-14 -1.64140990579885 1.49666938681079e-12 miRNAWalker2_validate -0.265639128307335 3.9945374923581e-13 NA NA NA hsa-miR-320b CCND2 0.226640952564488 0.378818692487242 -1.64140990579885 1.49666938681079e-12 mirMAP;miRNATAP -0.123605256651271 0.00373003525561283 NA NA NA hsa-miR-324-3p CCND2 -0.0774700133118458 0.689226297032231 -1.64140990579885 1.49666938681079e-12 miRNAWalker2_validate -0.276159423764137 9.9462768745637e-07 NA NA NA hsa-miR-331-5p CCND2 0.578237334664505 0.00131211239210882 -1.64140990579885 1.49666938681079e-12 miRNATAP -0.275952758002927 9.36107182529594e-06 NA NA NA hsa-miR-429 CCND2 2.3794516574089 1.72813419703734e-13 -1.64140990579885 1.49666938681079e-12 miRNATAP -0.209322906628109 2.95963655497587e-09 NA NA NA hsa-miR-450b-5p CCND2 1.69248953402469 1.96052058003353e-07 -1.64140990579885 1.49666938681079e-12 MirTarget;PITA;miRNATAP -0.145422700655101 8.53356735526403e-05 NA NA NA hsa-miR-501-5p CCND2 0.411357595674671 0.10435288464149 -1.64140990579885 1.49666938681079e-12 PITA;mirMAP;miRNATAP -0.144149908130612 0.000856140982438327 NA NA NA hsa-miR-503-5p CCND2 1.97129438815516 2.1704434283035e-09 -1.64140990579885 1.49666938681079e-12 MirTarget -0.132569636435255 4.69239346000773e-05 25860935 We then identified two targets of miR-503 CCND2 and CCND3 breast cancer hsa-miR-550a-5p CCND2 0.59977150019756 0.0314775340172755 -1.64140990579885 1.49666938681079e-12 MirTarget -0.220699899618513 1.33146855439522e-08 NA NA NA hsa-miR-589-3p CCND2 1.34253876396688 1.84935927493927e-05 -1.64140990579885 1.49666938681079e-12 mirMAP -0.194613807523332 3.68596504229146e-08 NA NA NA hsa-miR-590-3p CCND2 0.83851360565783 0.00129224433453587 -1.64140990579885 1.49666938681079e-12 miRanda;mirMAP -0.133052154455084 0.00820830741469702 NA NA NA hsa-miR-590-5p CCND2 2.07441240363458 4.95240551694843e-14 -1.64140990579885 1.49666938681079e-12 mirMAP -0.258740782004531 5.16823341358779e-08 NA NA NA hsa-miR-660-5p CCND2 2.04875198906126 1.08269480928897e-17 -1.64140990579885 1.49666938681079e-12 mirMAP -0.145565210932688 0.00131443056428649 NA NA NA hsa-miR-7-1-3p CCND2 2.61364240402652 1.98959237815786e-32 -1.64140990579885 1.49666938681079e-12 mirMAP -0.259792711431322 7.83559584811719e-08 NA NA NA hsa-miR-877-5p CCND2 -0.370234513208225 0.20670834111988 -1.64140990579885 1.49666938681079e-12 miRNAWalker2_validate -0.150269749089241 5.7135351515868e-05 NA NA NA hsa-miR-93-5p CCND2 1.50844106515467 1.83836866996875e-12 -1.64140990579885 1.49666938681079e-12 miRNATAP -0.414585687663892 1.04746846150745e-17 NA NA NA hsa-miR-96-5p CCND2 3.0381097138467 4.40362891630201e-24 -1.64140990579885 1.49666938681079e-12 TargetScan;miRNATAP -0.357833634781266 1.13611538125112e-20 NA NA NA hsa-miR-320b CCND3 0.226640952564488 0.378818692487242 -0.858556164090156 9.93688486289821e-06 miRanda -0.106740567141186 0.00235090988932412 NA NA NA hsa-miR-421 CCND3 0.170525317701774 0.535277026680289 -0.858556164090156 9.93688486289821e-06 PITA;miRanda -0.120402813664522 0.000730915299268324 NA NA NA hsa-miR-96-5p CCND3 3.0381097138467 4.40362891630201e-24 -0.858556164090156 9.93688486289821e-06 TargetScan -0.12470872406597 0.000146574618288945 NA NA NA hsa-miR-324-5p CISH 1.06955541886548 5.39722006604758e-05 -0.622250605476491 0.0135610143704485 miRanda -0.136681451949253 0.00171098684386632 NA NA NA hsa-miR-185-3p CLCF1 -0.377490365509078 0.093653288903368 1.22238453457647 1.05360160305454e-05 MirTarget -0.17299534627822 0.00257366528361898 NA NA NA hsa-miR-30d-5p CLCF1 -0.920901858717441 3.50898334321668e-05 1.22238453457647 1.05360160305454e-05 miRNATAP -0.158100997076121 0.00612064448708459 NA NA NA hsa-miR-421 CLCF1 0.170525317701774 0.535277026680289 1.22238453457647 1.05360160305454e-05 miRanda -0.288607768833781 1.00079790992025e-08 NA NA NA hsa-miR-21-5p CNTFR 4.38165933891779 1.52536633902505e-92 -4.21369767454556 2.77734402633409e-16 miRNATAP -0.788895771367738 2.05910932862296e-18 NA NA NA hsa-miR-27b-5p CNTFR 1.03511957999268 7.86187917705303e-11 -4.21369767454556 2.77734402633409e-16 miRNATAP -0.50136170086537 0.000992458086838241 NA NA NA hsa-miR-28-5p CNTFR 1.19639196514745 4.59365801666536e-18 -4.21369767454556 2.77734402633409e-16 PITA;miRanda;miRNATAP -0.564486542498125 0.00112026820103331 NA NA NA hsa-miR-589-5p CNTFR 0.233778899379261 0.228477190986199 -4.21369767454556 2.77734402633409e-16 miRNATAP -0.435430153385876 0.000605291700381956 NA NA NA hsa-miR-590-5p CNTFR 2.07441240363458 4.95240551694843e-14 -4.21369767454556 2.77734402633409e-16 PITA;miRanda;miRNATAP -0.535644117845789 5.23035110551345e-07 NA NA NA hsa-miR-708-5p CNTFR 3.04047795672813 3.01085192850869e-20 -4.21369767454556 2.77734402633409e-16 miRNATAP -0.432221958357625 4.02929003725808e-08 NA NA NA hsa-miR-9-5p CNTFR 4.99250901331516 2.59132733422801e-19 -4.21369767454556 2.77734402633409e-16 miRNATAP -0.232115720626389 2.76782498463419e-08 NA NA NA hsa-miR-26b-5p CREBBP 0.72362441215247 4.7794659748036e-05 -0.117888962254313 0.332704389567094 miRNATAP -0.107061826766823 0.00062047995861088 NA NA NA hsa-miR-590-3p CREBBP 0.83851360565783 0.00129224433453587 -0.117888962254313 0.332704389567094 PITA;miRanda;mirMAP;miRNATAP -0.141497558961106 2.26793984615809e-08 NA NA NA hsa-miR-429 CSF2RA 2.3794516574089 1.72813419703734e-13 -0.667179216502516 0.0229834295286541 miRanda -0.275229781089926 2.44207622952055e-10 NA NA NA hsa-miR-15b-3p CSF2RB 0.804736041893915 0.000400279611457186 -1.28440879414381 5.98600010060944e-07 mirMAP -0.146763154921606 0.00821763442889796 NA NA NA hsa-miR-181d-5p CSF2RB 1.19058140522592 8.5908558852417e-09 -1.28440879414381 5.98600010060944e-07 MirTarget -0.225138318949885 7.93227254228292e-05 NA NA NA hsa-miR-19a-3p CSF2RB 2.11776595911517 7.07663078397156e-10 -1.28440879414381 5.98600010060944e-07 MirTarget -0.167733606420829 3.84098493798594e-05 NA NA NA hsa-miR-19b-3p CSF2RB 2.10868505662119 5.40846613768389e-17 -1.28440879414381 5.98600010060944e-07 MirTarget -0.250069990582844 1.95558645843003e-07 NA NA NA hsa-miR-200a-3p CSF3 3.14766878548496 1.32850889777422e-21 -3.80391444649431 7.58847238583904e-10 miRNATAP -0.245268194082103 0.00442533873575079 NA NA NA hsa-miR-28-5p CSF3 1.19639196514745 4.59365801666536e-18 -3.80391444649431 7.58847238583904e-10 miRanda -0.695441224202475 0.00068192834511052 NA NA NA hsa-miR-542-3p CSF3 1.62226640768239 2.6427102465476e-10 -3.80391444649431 7.58847238583904e-10 miRanda -0.30945371476692 0.00530732373682463 NA NA NA hsa-miR-940 CSF3R 0.011138136211269 0.974925352379525 -1.77217614776242 7.01059226795045e-07 MirTarget -0.138211106157438 0.00891583497939948 NA NA NA hsa-miR-590-3p CTF1 0.83851360565783 0.00129224433453587 -0.900986763491683 0.000319151003326077 miRanda -0.208749150023805 8.24807209764519e-05 NA NA NA hsa-miR-140-5p EP300 0.669142684153918 0.000335928403032308 -0.24151027236021 0.0464135090934499 miRNAWalker2_validate -0.132228422733875 1.433084313638e-05 NA NA NA hsa-miR-142-5p EP300 1.29672439149353 4.0768822158894e-06 -0.24151027236021 0.0464135090934499 PITA;mirMAP;miRNATAP -0.121097424575162 7.94195192122639e-09 23342264 In contrast to the mouse p300 gene the human p300 gene was not found to be a target for miR-142-5p B cell lymphoma hsa-miR-26b-5p EP300 0.72362441215247 4.7794659748036e-05 -0.24151027236021 0.0464135090934499 miRNAWalker2_validate;miRNATAP -0.189576310673603 7.38860268524093e-10 NA NA NA hsa-miR-342-3p EP300 -0.128691966564961 0.561034080130801 -0.24151027236021 0.0464135090934499 MirTarget;PITA;miRanda;miRNATAP -0.163349604222849 4.45040401044694e-11 NA NA NA hsa-miR-590-3p EP300 0.83851360565783 0.00129224433453587 -0.24151027236021 0.0464135090934499 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.131033799746553 2.28041521831593e-07 NA NA NA hsa-miR-96-5p EP300 3.0381097138467 4.40362891630201e-24 -0.24151027236021 0.0464135090934499 TargetScan;miRNATAP -0.111815289027979 2.63317047880807e-08 NA NA NA hsa-miR-127-3p EPOR -0.723429813065737 0.0192747925933947 -0.145534212833245 0.465074577214786 miRanda -0.135114313646344 4.18955941435971e-06 NA NA NA hsa-miR-330-3p EPOR -0.716924999893351 0.000796236278616087 -0.145534212833245 0.465074577214786 mirMAP -0.149653706086766 0.000458105748043046 NA NA NA hsa-miR-142-3p GHR 3.98476449801341 1.56256182021111e-35 -2.71079913438272 1.27737998879726e-18 MirTarget;PITA;miRanda;miRNATAP -0.240178402806526 1.0549361908914e-08 NA NA NA hsa-miR-15a-5p GHR 1.62575353599172 1.55312121019827e-19 -2.71079913438272 1.27737998879726e-18 MirTarget;miRNATAP -0.400842253213854 3.19898591344609e-07 NA NA NA hsa-miR-16-2-3p GHR 0.503964803530872 0.0263648405197492 -2.71079913438272 1.27737998879726e-18 mirMAP -0.318740264994176 5.63668150944797e-06 NA NA NA hsa-miR-16-5p GHR 0.749619098384047 4.11649450706988e-06 -2.71079913438272 1.27737998879726e-18 MirTarget;miRNATAP -0.370703042948598 3.89836833751239e-05 NA NA NA hsa-miR-29a-5p GHR 1.89519956688438 1.03453349363915e-11 -2.71079913438272 1.27737998879726e-18 mirMAP;miRNATAP -0.407579980761912 1.93886667487704e-11 NA NA NA hsa-miR-3607-3p GHR 2.4103172144469 2.69039449048047e-08 -2.71079913438272 1.27737998879726e-18 mirMAP -0.107560273031406 0.00128183659789109 NA NA NA hsa-miR-421 GHR 0.170525317701774 0.535277026680289 -2.71079913438272 1.27737998879726e-18 miRanda -0.257993079486087 8.6932681900049e-06 NA NA NA hsa-miR-424-5p GHR 1.26485330287919 6.1498991028257e-06 -2.71079913438272 1.27737998879726e-18 MirTarget;miRNATAP -0.252527058710918 1.09153368104669e-06 NA NA NA hsa-miR-429 GHR 2.3794516574089 1.72813419703734e-13 -2.71079913438272 1.27737998879726e-18 miRanda;miRNATAP -0.197468687622676 3.83302326881649e-05 NA NA NA hsa-miR-590-3p GHR 0.83851360565783 0.00129224433453587 -2.71079913438272 1.27737998879726e-18 mirMAP -0.442688732144415 2.6819424381772e-11 NA NA NA hsa-miR-624-5p GHR -0.0554776050468686 0.829845479813552 -2.71079913438272 1.27737998879726e-18 MirTarget -0.287083525536995 7.08976390565227e-06 NA NA NA hsa-miR-651-5p GHR 1.67013048675395 1.61458229225137e-07 -2.71079913438272 1.27737998879726e-18 MirTarget -0.253725916706089 7.28248825124979e-06 NA NA NA hsa-miR-7-1-3p GHR 2.61364240402652 1.98959237815786e-32 -2.71079913438272 1.27737998879726e-18 MirTarget;mirMAP -0.49394038620697 1.28503004114502e-14 NA NA NA hsa-miR-27b-3p GRB2 0.236438984240408 0.12263510345883 -0.210706496557246 0.0100478898753454 MirTarget;miRNATAP -0.113414213940692 3.83461454675988e-06 NA NA NA hsa-miR-106b-5p IFNAR2 1.47447672652218 1.32004094930462e-13 0.140550219738166 0.332339267782678 miRNAWalker2_validate -0.1472266221605 5.70106557312633e-06 NA NA NA hsa-miR-141-3p IFNAR2 3.36993755486106 5.42939251147195e-32 0.140550219738166 0.332339267782678 mirMAP -0.10951748988711 3.35192739367357e-07 NA NA NA hsa-miR-330-5p IFNAR2 0.168520831101569 0.336433937906706 0.140550219738166 0.332339267782678 miRanda -0.13552778390331 0.000387750870407834 NA NA NA hsa-miR-484 IFNAR2 -0.228576985124486 0.244112867390855 0.140550219738166 0.332339267782678 miRNAWalker2_validate -0.11120746642306 0.00109782681141026 NA NA NA hsa-miR-125a-5p IFNG -1.04824536696301 3.97386082850476e-07 0.94292929984472 0.0608038552261288 miRanda -0.406629276351702 0.000246687750342703 NA NA NA hsa-miR-429 IFNG 2.3794516574089 1.72813419703734e-13 0.94292929984472 0.0608038552261288 miRanda -0.350712861617547 3.11820952772387e-06 NA NA NA hsa-miR-429 IFNGR1 2.3794516574089 1.72813419703734e-13 -1.10038416048233 1.78283624470356e-12 miRNATAP -0.11056644127962 3.60660369706507e-06 NA NA NA hsa-let-7e-5p IL10 -0.749418249305995 7.34668338492227e-05 -0.434461664261276 0.143095765694739 miRNATAP -0.197028950598552 0.00636919455754822 NA NA NA hsa-miR-27b-3p IL10 0.236438984240408 0.12263510345883 -0.434461664261276 0.143095765694739 miRNATAP -0.250699467341108 0.00546636303334765 NA NA NA hsa-miR-107 IL10RB 0.658676029898313 5.11480446318819e-07 -0.156786543069472 0.196975509668276 miRanda -0.146145770458465 0.000601879412584398 NA NA NA hsa-miR-204-5p IL11 -1.01965803752657 0.00767207541525746 1.88628648819733 3.75415961544606e-06 miRNAWalker2_validate;miRTarBase;MirTarget -0.132609006506597 0.00801904774579794 NA NA NA hsa-miR-361-3p IL11 0.0988926195529967 0.549128728500555 1.88628648819733 3.75415961544606e-06 MirTarget -0.417896138745006 0.000310293312241576 NA NA NA hsa-miR-330-5p IL11RA 0.168520831101569 0.336433937906706 -1.23954424977139 6.63773713533185e-11 miRanda -0.216088630672856 2.31628322187916e-05 NA NA NA hsa-miR-320b IL12B 0.226640952564488 0.378818692487242 0.599174744684666 0.0773534155568406 MirTarget;miRanda -0.190075409925426 0.00176564551717167 NA NA NA hsa-miR-421 IL12B 0.170525317701774 0.535277026680289 0.599174744684666 0.0773534155568406 miRanda -0.244565369947658 7.22335142916446e-05 NA NA NA hsa-miR-125a-5p IL12RB2 -1.04824536696301 3.97386082850476e-07 0.948444607728226 0.0187241432805944 miRanda -0.40106931059239 6.18864860176977e-06 NA NA NA hsa-miR-338-3p IL12RB2 0.726843067232002 0.0506251324215494 0.948444607728226 0.0187241432805944 miRanda -0.222881287039234 7.11621180319593e-06 NA NA NA hsa-miR-16-2-3p IL13RA1 0.503964803530872 0.0263648405197492 -0.0486994315482141 0.702743897814099 MirTarget -0.150747425112068 5.3936307409038e-08 NA NA NA hsa-miR-186-5p IL13RA1 0.852175445703945 6.88885738584309e-10 -0.0486994315482141 0.702743897814099 MirTarget;mirMAP -0.196745858838228 2.57644786130124e-06 NA NA NA hsa-miR-590-5p IL13RA2 2.07441240363458 4.95240551694843e-14 -1.25869584346649 0.0234884521598843 miRanda -0.369457223762037 0.00100744093509177 NA NA NA hsa-miR-130b-3p IL15 1.83046548750752 5.04753914574694e-13 -0.73920589631764 0.00191051132670785 MirTarget -0.163871207841701 0.000235173367078808 NA NA NA hsa-miR-148b-3p IL15 0.483970528590224 0.0026495409465901 -0.73920589631764 0.00191051132670785 MirTarget -0.225338962698826 0.00103510937176316 NA NA NA hsa-miR-19b-3p IL15 2.10868505662119 5.40846613768389e-17 -0.73920589631764 0.00191051132670785 MirTarget -0.136221728289389 0.00222141143696732 NA NA NA hsa-miR-324-5p IL15 1.06955541886548 5.39722006604758e-05 -0.73920589631764 0.00191051132670785 miRanda -0.166264169404551 5.24035309374909e-05 NA NA NA hsa-miR-429 IL15 2.3794516574089 1.72813419703734e-13 -0.73920589631764 0.00191051132670785 miRanda -0.214920038624398 1.29407855427688e-09 NA NA NA hsa-miR-129-5p IL20RA -0.405735314747643 0.341485636033577 -2.15151378984819 1.5400622268436e-07 miRanda -0.145014301683731 0.00127704897275724 NA NA NA hsa-miR-125a-3p IL21R -1.04954492275266 2.45974219476832e-06 0.691003692348375 0.0167928179487843 MirTarget;miRanda -0.188211112830916 0.00151656380442067 NA NA NA hsa-miR-148b-3p IL21R 0.483970528590224 0.0026495409465901 0.691003692348375 0.0167928179487843 miRNAWalker2_validate -0.239656350706097 0.00401733766278859 NA NA NA hsa-miR-335-5p IL21R -0.466533891325811 0.0676987038122831 0.691003692348375 0.0167928179487843 miRNAWalker2_validate -0.279593215569236 1.4531413152246e-06 NA NA NA hsa-miR-421 IL22RA2 0.170525317701774 0.535277026680289 3.67157122847723 8.78649169788234e-13 miRanda -0.248157534188401 0.00988655838325266 NA NA NA hsa-miR-203a-3p IL24 1.06866854356847 0.00389979689199624 0.0360054903349241 0.916586467712013 miRTarBase;MirTarget -0.127704900436559 0.00265675051589938 NA NA NA hsa-miR-3065-3p IL2RA 0.381740717819351 0.30795546546997 0.941342741224751 0.00410378005200245 MirTarget -0.142032683072737 0.00043178257494938 NA NA NA hsa-miR-324-5p IL5RA 1.06955541886548 5.39722006604758e-05 -2.6285708775074 6.5750785940703e-08 miRanda -0.268503815682519 0.00162922620695642 NA NA NA hsa-miR-542-3p IL5RA 1.62226640768239 2.6427102465476e-10 -2.6285708775074 6.5750785940703e-08 miRanda -0.353741999798382 4.36368041041035e-05 NA NA NA hsa-miR-361-5p IL6 0.21454431962475 0.0800957579368424 -2.77649282936041 1.75717225104248e-11 miRanda -0.437759355067832 0.00687022648152616 NA NA NA hsa-miR-429 IL6 2.3794516574089 1.72813419703734e-13 -2.77649282936041 1.75717225104248e-11 miRanda -0.430343117737244 4.74829761062858e-12 NA NA NA hsa-miR-106a-5p IL6R 1.3902608059488 6.07931522284525e-05 -1.1746226729414 2.27195491770167e-06 mirMAP -0.218074678741591 2.2042752508132e-09 NA NA NA hsa-miR-106b-5p IL6R 1.47447672652218 1.32004094930462e-13 -1.1746226729414 2.27195491770167e-06 mirMAP -0.350202808805077 3.4833398229178e-10 NA NA NA hsa-miR-130a-3p IL6R 0.881660100597014 0.000158893668519248 -1.1746226729414 2.27195491770167e-06 mirMAP -0.155371931802609 0.00162007530132916 NA NA NA hsa-miR-130b-3p IL6R 1.83046548750752 5.04753914574694e-13 -1.1746226729414 2.27195491770167e-06 mirMAP -0.413149194390995 5.14327108475923e-20 NA NA NA hsa-miR-141-3p IL6R 3.36993755486106 5.42939251147195e-32 -1.1746226729414 2.27195491770167e-06 MirTarget -0.113765005170378 0.00249311441364036 NA NA NA hsa-miR-141-5p IL6R 3.02575703771074 1.54385222591327e-32 -1.1746226729414 2.27195491770167e-06 MirTarget -0.116574683527499 0.00584925280444116 NA NA NA hsa-miR-17-5p IL6R 2.07078488653279 2.77403038572568e-19 -1.1746226729414 2.27195491770167e-06 mirMAP -0.244716956140182 2.99341970524535e-07 NA NA NA hsa-miR-193a-3p IL6R 0.549173467360291 0.0319030569365466 -1.1746226729414 2.27195491770167e-06 mirMAP -0.288592318482886 2.36933002614249e-09 NA NA NA hsa-miR-193b-3p IL6R 1.10444771306846 0.000822888533401377 -1.1746226729414 2.27195491770167e-06 mirMAP -0.183254512449137 1.0448823932318e-07 NA NA NA hsa-miR-20a-5p IL6R 2.64649625616975 5.1469418982085e-27 -1.1746226729414 2.27195491770167e-06 mirMAP -0.185356001527945 2.70729728290465e-05 NA NA NA hsa-miR-20b-5p IL6R 1.35770573270947 0.00260808530013016 -1.1746226729414 2.27195491770167e-06 mirMAP -0.156868294348864 3.3112376138858e-09 NA NA NA hsa-miR-21-5p IL6R 4.38165933891779 1.52536633902505e-92 -1.1746226729414 2.27195491770167e-06 MirTarget;miRNATAP -0.198071898371476 5.86460332384805e-06 NA NA NA hsa-miR-22-3p IL6R 1.42501909916631 1.72295005910055e-25 -1.1746226729414 2.27195491770167e-06 MirTarget -0.215724062710191 0.00790869912542495 NA NA NA hsa-miR-301a-3p IL6R 2.70198002906399 1.56420889710984e-14 -1.1746226729414 2.27195491770167e-06 mirMAP -0.194456583370885 7.12633405994253e-07 NA NA NA hsa-miR-320b IL6R 0.226640952564488 0.378818692487242 -1.1746226729414 2.27195491770167e-06 miRanda;miRNATAP -0.183694444376242 4.10299857449601e-05 NA NA NA hsa-miR-33a-5p IL6R 2.80127809675219 5.09053890529424e-12 -1.1746226729414 2.27195491770167e-06 mirMAP -0.165953433237246 1.20456750443638e-06 NA NA NA hsa-miR-421 IL6R 0.170525317701774 0.535277026680289 -1.1746226729414 2.27195491770167e-06 mirMAP -0.260333625187544 8.13554387283894e-09 NA NA NA hsa-miR-454-3p IL6R 1.49453641052169 4.46235742871434e-09 -1.1746226729414 2.27195491770167e-06 mirMAP -0.221062065152908 3.30345689392872e-05 NA NA NA hsa-miR-576-5p IL6R 1.02693643167056 1.14846964470173e-06 -1.1746226729414 2.27195491770167e-06 mirMAP -0.222840698184183 3.80996036993166e-05 NA NA NA hsa-miR-590-3p IL6R 0.83851360565783 0.00129224433453587 -1.1746226729414 2.27195491770167e-06 mirMAP -0.210607261143576 6.80895496632582e-05 NA NA NA hsa-miR-590-5p IL6R 2.07441240363458 4.95240551694843e-14 -1.1746226729414 2.27195491770167e-06 MirTarget;miRNATAP -0.333991322213794 1.89564370294894e-11 NA NA NA hsa-miR-708-3p IL6R 3.43841959417743 4.40027692981683e-28 -1.1746226729414 2.27195491770167e-06 mirMAP -0.24480911276646 1.39639357491191e-10 NA NA NA hsa-miR-93-5p IL6R 1.50844106515467 1.83836866996875e-12 -1.1746226729414 2.27195491770167e-06 mirMAP -0.30062611296742 8.25015656889055e-09 NA NA NA hsa-miR-942-5p IL6R -0.0372813055050076 0.870631058767894 -1.1746226729414 2.27195491770167e-06 MirTarget -0.259354017517313 4.92891498625763e-07 NA NA NA hsa-miR-1301-3p IL6ST 0.845987603184611 0.000579808501723616 -1.39734012929419 9.70680145490152e-07 MirTarget -0.26008804085476 1.13573408886211e-06 NA NA NA hsa-miR-130a-3p IL6ST 0.881660100597014 0.000158893668519248 -1.39734012929419 9.70680145490152e-07 mirMAP;miRNATAP -0.245486745626666 1.34163975605953e-05 NA NA NA hsa-miR-130b-3p IL6ST 1.83046548750752 5.04753914574694e-13 -1.39734012929419 9.70680145490152e-07 miRNATAP -0.336108340624494 2.36353416635985e-10 NA NA NA hsa-miR-136-5p IL6ST 2.07553688303449 4.53553108822501e-09 -1.39734012929419 9.70680145490152e-07 MirTarget -0.172506681666682 2.49974177314741e-06 NA NA NA hsa-miR-142-3p IL6ST 3.98476449801341 1.56256182021111e-35 -1.39734012929419 9.70680145490152e-07 miRanda;miRNATAP -0.192088983517046 4.23048332200066e-07 NA NA NA hsa-miR-148b-5p IL6ST 1.39335695292409 2.13220380550073e-07 -1.39734012929419 9.70680145490152e-07 mirMAP -0.355143375149023 8.10651349802271e-10 NA NA NA hsa-miR-16-1-3p IL6ST 1.50034693398929 6.63958242991125e-10 -1.39734012929419 9.70680145490152e-07 mirMAP -0.358511772839128 5.93322692085018e-08 NA NA NA hsa-miR-16-2-3p IL6ST 0.503964803530872 0.0263648405197492 -1.39734012929419 9.70680145490152e-07 mirMAP -0.320862227228075 3.6812616056642e-07 NA NA NA hsa-miR-17-5p IL6ST 2.07078488653279 2.77403038572568e-19 -1.39734012929419 9.70680145490152e-07 TargetScan -0.392732247457947 4.0749528126192e-13 NA NA NA hsa-miR-182-5p IL6ST 3.21839823004635 5.13049145201115e-39 -1.39734012929419 9.70680145490152e-07 mirMAP -0.155704807222551 0.0016568938089877 NA NA NA hsa-miR-186-5p IL6ST 0.852175445703945 6.88885738584309e-10 -1.39734012929419 9.70680145490152e-07 MirTarget;mirMAP -0.405855626850133 2.03935143087099e-05 NA NA NA hsa-miR-19a-3p IL6ST 2.11776595911517 7.07663078397156e-10 -1.39734012929419 9.70680145490152e-07 mirMAP;miRNATAP -0.380225948889316 3.88377910739829e-18 NA NA NA hsa-miR-19b-3p IL6ST 2.10868505662119 5.40846613768389e-17 -1.39734012929419 9.70680145490152e-07 mirMAP;miRNATAP -0.358222197518629 1.10199239659786e-11 NA NA NA hsa-miR-20a-3p IL6ST 2.51803599558247 4.92479325298629e-13 -1.39734012929419 9.70680145490152e-07 mirMAP -0.250002879329522 1.44938939059583e-07 NA NA NA hsa-miR-21-5p IL6ST 4.38165933891779 1.52536633902505e-92 -1.39734012929419 9.70680145490152e-07 mirMAP -0.297109673399402 2.53136271525559e-09 NA NA NA hsa-miR-2355-3p IL6ST 1.10676344164715 6.24068383465151e-06 -1.39734012929419 9.70680145490152e-07 MirTarget;miRNATAP -0.250375747943542 9.37237483300948e-06 NA NA NA hsa-miR-24-1-5p IL6ST 0.856025727237819 0.000107354490323658 -1.39734012929419 9.70680145490152e-07 MirTarget -0.284429535265672 5.93473902119159e-06 NA NA NA hsa-miR-24-2-5p IL6ST 1.43704663046967 4.34375016509278e-11 -1.39734012929419 9.70680145490152e-07 MirTarget -0.475500357234955 2.49217549927224e-16 NA NA NA hsa-miR-26a-2-3p IL6ST 0.264287787772609 0.305653616292982 -1.39734012929419 9.70680145490152e-07 MirTarget -0.289332224551955 6.17664943138594e-06 NA NA NA hsa-miR-26b-5p IL6ST 0.72362441215247 4.7794659748036e-05 -1.39734012929419 9.70680145490152e-07 mirMAP -0.315247963329803 2.18776870540077e-05 NA NA NA hsa-miR-29a-5p IL6ST 1.89519956688438 1.03453349363915e-11 -1.39734012929419 9.70680145490152e-07 mirMAP -0.362695291426048 3.5481895342024e-11 NA NA NA hsa-miR-29b-1-5p IL6ST 1.71024742617744 3.64915691793611e-09 -1.39734012929419 9.70680145490152e-07 MirTarget -0.243143669584943 4.85669689473781e-08 NA NA NA hsa-miR-29b-3p IL6ST 3.10527711861309 3.01242507282711e-32 -1.39734012929419 9.70680145490152e-07 mirMAP -0.303034037255053 5.95164161289728e-11 NA NA NA hsa-miR-301a-3p IL6ST 2.70198002906399 1.56420889710984e-14 -1.39734012929419 9.70680145490152e-07 mirMAP;miRNATAP -0.297633150346183 2.54419026392627e-11 NA NA NA hsa-miR-30b-5p IL6ST 0.358144314839612 0.138026229059594 -1.39734012929419 9.70680145490152e-07 mirMAP -0.143353679972239 0.00941146284888011 NA NA NA hsa-miR-30c-5p IL6ST -0.327319105755825 0.123595832152687 -1.39734012929419 9.70680145490152e-07 mirMAP -0.196951081998725 0.00168672851637458 NA NA NA hsa-miR-335-3p IL6ST 1.51116383169018 6.88553098788624e-13 -1.39734012929419 9.70680145490152e-07 MirTarget;mirMAP -0.18135568556984 0.00332336802072523 NA NA NA hsa-miR-33a-5p IL6ST 2.80127809675219 5.09053890529424e-12 -1.39734012929419 9.70680145490152e-07 mirMAP -0.274736292965394 1.33477417350888e-12 NA NA NA hsa-miR-362-3p IL6ST 0.194097672030785 0.52808475179225 -1.39734012929419 9.70680145490152e-07 PITA;miRanda;miRNATAP -0.177684969314128 0.00100549249355894 NA NA NA hsa-miR-362-5p IL6ST 0.658947634569393 0.0243306847205756 -1.39734012929419 9.70680145490152e-07 mirMAP -0.236519023780965 2.89272946301179e-07 NA NA NA hsa-miR-374b-3p IL6ST -0.157526212601818 0.538677664999491 -1.39734012929419 9.70680145490152e-07 MirTarget -0.195125660836267 0.00198817955213141 NA NA NA hsa-miR-421 IL6ST 0.170525317701774 0.535277026680289 -1.39734012929419 9.70680145490152e-07 PITA;miRanda;mirMAP -0.154848271352363 0.00323644445056223 NA NA NA hsa-miR-429 IL6ST 2.3794516574089 1.72813419703734e-13 -1.39734012929419 9.70680145490152e-07 PITA;miRanda;mirMAP;miRNATAP -0.184123799658201 2.02116872333496e-05 NA NA NA hsa-miR-454-3p IL6ST 1.49453641052169 4.46235742871434e-09 -1.39734012929419 9.70680145490152e-07 mirMAP;miRNATAP -0.487570897094484 2.93290407451549e-16 NA NA NA hsa-miR-501-5p IL6ST 0.411357595674671 0.10435288464149 -1.39734012929419 9.70680145490152e-07 mirMAP -0.200214401338041 0.000131743066227343 NA NA NA hsa-miR-505-3p IL6ST 0.239188197517314 0.273992679374017 -1.39734012929419 9.70680145490152e-07 MirTarget -0.212938984412526 0.000471593594838731 NA NA NA hsa-miR-576-5p IL6ST 1.02693643167056 1.14846964470173e-06 -1.39734012929419 9.70680145490152e-07 mirMAP -0.411592480608644 1.85858999356582e-11 NA NA NA hsa-miR-582-5p IL6ST 1.08286181406653 0.00149040450161757 -1.39734012929419 9.70680145490152e-07 mirMAP -0.134113118739886 0.000738374286065746 NA NA NA hsa-miR-589-3p IL6ST 1.34253876396688 1.84935927493927e-05 -1.39734012929419 9.70680145490152e-07 mirMAP -0.18271980122973 2.32096538416074e-05 NA NA NA hsa-miR-590-3p IL6ST 0.83851360565783 0.00129224433453587 -1.39734012929419 9.70680145490152e-07 miRNAWalker2_validate;miRanda;mirMAP;miRNATAP -0.382600679035766 1.80416732314359e-10 NA NA NA hsa-miR-590-5p IL6ST 2.07441240363458 4.95240551694843e-14 -1.39734012929419 9.70680145490152e-07 mirMAP -0.528213109351482 3.30843605529863e-21 NA NA NA hsa-miR-629-3p IL6ST 1.31892116211001 0.000114487182853678 -1.39734012929419 9.70680145490152e-07 miRNATAP -0.172380322146685 3.58710002510921e-05 NA NA NA hsa-miR-7-1-3p IL6ST 2.61364240402652 1.98959237815786e-32 -1.39734012929419 9.70680145490152e-07 mirMAP -0.243853566250656 3.65139611311675e-05 NA NA NA hsa-miR-708-3p IL6ST 3.43841959417743 4.40027692981683e-28 -1.39734012929419 9.70680145490152e-07 mirMAP -0.233838905546436 1.19585131438482e-07 NA NA NA hsa-miR-766-3p IL6ST 0.0784037775118556 0.760091599198293 -1.39734012929419 9.70680145490152e-07 MirTarget -0.158656930946095 0.0022216504968731 NA NA NA hsa-miR-93-3p IL6ST 1.07631808403007 1.63747525692813e-05 -1.39734012929419 9.70680145490152e-07 MirTarget -0.304548718771363 5.1268521328909e-09 NA NA NA hsa-miR-335-3p IL7 1.51116383169018 6.88553098788624e-13 -0.702514086438196 0.00932145759239818 mirMAP -0.26373886255117 4.63035348071129e-06 NA NA NA hsa-miR-429 IL7 2.3794516574089 1.72813419703734e-13 -0.702514086438196 0.00932145759239818 miRanda -0.129585970599044 0.00145437595310485 NA NA NA hsa-miR-335-3p IL7R 1.51116383169018 6.88553098788624e-13 -2.24247041370452 2.58321797620589e-09 mirMAP -0.38178183644854 2.76716017152587e-06 NA NA NA hsa-miR-450b-5p IL7R 1.69248953402469 1.96052058003353e-07 -2.24247041370452 2.58321797620589e-09 mirMAP -0.240442973288861 5.51469958709109e-05 NA NA NA hsa-miR-501-5p IL7R 0.411357595674671 0.10435288464149 -2.24247041370452 2.58321797620589e-09 mirMAP -0.235161850813912 0.000736985517218325 NA NA NA hsa-miR-576-5p IL7R 1.02693643167056 1.14846964470173e-06 -2.24247041370452 2.58321797620589e-09 mirMAP -0.241502374217978 0.00361035935418838 NA NA NA hsa-miR-7-1-3p IL7R 2.61364240402652 1.98959237815786e-32 -2.24247041370452 2.58321797620589e-09 mirMAP -0.352356221963728 6.81076457228874e-06 NA NA NA hsa-let-7g-3p JAK1 2.38336858943031 4.8771148585792e-17 -0.603898351740195 2.60299135232136e-07 MirTarget -0.109925124338959 1.65988376328151e-09 NA NA NA hsa-miR-106a-5p JAK1 1.3902608059488 6.07931522284525e-05 -0.603898351740195 2.60299135232136e-07 MirTarget -0.109787666786419 1.46945811917045e-10 NA NA NA hsa-miR-106b-5p JAK1 1.47447672652218 1.32004094930462e-13 -0.603898351740195 2.60299135232136e-07 miRNAWalker2_validate;MirTarget -0.199500375609548 1.80265958380738e-14 NA NA NA hsa-miR-128-3p JAK1 1.03509868349735 2.11606310588315e-10 -0.603898351740195 2.60299135232136e-07 miRNAWalker2_validate -0.159074099467127 1.23753139998692e-06 NA NA NA hsa-miR-17-5p JAK1 2.07078488653279 2.77403038572568e-19 -0.603898351740195 2.60299135232136e-07 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.20376007792571 8.88259339183568e-21 NA NA NA hsa-miR-20a-5p JAK1 2.64649625616975 5.1469418982085e-27 -0.603898351740195 2.60299135232136e-07 MirTarget -0.166035806154834 2.64870349477136e-16 NA NA NA hsa-miR-28-5p JAK1 1.19639196514745 4.59365801666536e-18 -0.603898351740195 2.60299135232136e-07 miRanda;miRNATAP -0.133759278277294 0.000497874854510592 NA NA NA hsa-miR-30b-5p JAK1 0.358144314839612 0.138026229059594 -0.603898351740195 2.60299135232136e-07 MirTarget -0.104673840168908 3.1208747081459e-06 NA NA NA hsa-miR-93-5p JAK1 1.50844106515467 1.83836866996875e-12 -0.603898351740195 2.60299135232136e-07 MirTarget;miRNATAP -0.206636582524429 8.9103689814827e-18 NA NA NA hsa-miR-181b-5p JAK2 0.668793269169928 0.000239998092406404 -0.905723361849239 1.08163009019368e-06 mirMAP -0.169203053791489 0.000355371075025635 NA NA NA hsa-miR-30b-3p JAK3 -1.20976737190106 2.63726511331003e-06 1.23261172398308 7.71882332097229e-09 MirTarget -0.13898568928562 0.000291464520270781 NA NA NA hsa-miR-335-5p JAK3 -0.466533891325811 0.0676987038122831 1.23261172398308 7.71882332097229e-09 miRNAWalker2_validate -0.179222820625557 3.98036017298197e-05 NA NA NA hsa-miR-150-5p LEP -0.702328520623782 0.0215316651134431 1.50820596704701 0.00395628840240177 mirMAP -0.269958451768909 0.000621658178274735 NA NA NA hsa-miR-342-3p LEP -0.128691966564961 0.561034080130801 1.50820596704701 0.00395628840240177 miRanda -0.298765083194092 0.00650935359390327 NA NA NA hsa-miR-107 LEPR 0.658676029898313 5.11480446318819e-07 -2.46480878630153 3.72826186858018e-17 miRanda -0.299663414219395 0.00511850697299028 NA NA NA hsa-miR-130b-5p LEPR 1.53645187062942 1.10498816261505e-08 -2.46480878630153 3.72826186858018e-17 mirMAP -0.279127759473693 3.43336358840995e-08 NA NA NA hsa-miR-146b-5p LEPR 1.0922867893808 5.63754607494775e-06 -2.46480878630153 3.72826186858018e-17 miRanda -0.227662622748099 7.325552492391e-05 NA NA NA hsa-miR-16-1-3p LEPR 1.50034693398929 6.63958242991125e-10 -2.46480878630153 3.72826186858018e-17 mirMAP -0.432624251951397 4.02166250701648e-10 NA NA NA hsa-miR-16-2-3p LEPR 0.503964803530872 0.0263648405197492 -2.46480878630153 3.72826186858018e-17 mirMAP -0.29838875330867 7.34888480104431e-06 NA NA NA hsa-miR-29a-5p LEPR 1.89519956688438 1.03453349363915e-11 -2.46480878630153 3.72826186858018e-17 mirMAP -0.382479268554506 3.09409065196251e-11 NA NA NA hsa-miR-335-3p LEPR 1.51116383169018 6.88553098788624e-13 -2.46480878630153 3.72826186858018e-17 mirMAP -0.267517928879763 3.50757186260394e-05 NA NA NA hsa-miR-429 LEPR 2.3794516574089 1.72813419703734e-13 -2.46480878630153 3.72826186858018e-17 miRanda;miRNATAP -0.179992460723382 7.57157335225179e-05 NA NA NA hsa-miR-576-5p LEPR 1.02693643167056 1.14846964470173e-06 -2.46480878630153 3.72826186858018e-17 PITA -0.340094265822741 1.70622239647101e-07 NA NA NA hsa-miR-590-3p LEPR 0.83851360565783 0.00129224433453587 -2.46480878630153 3.72826186858018e-17 miRanda;mirMAP -0.299169489372911 2.65577139526334e-06 NA NA NA hsa-miR-590-5p LEPR 2.07441240363458 4.95240551694843e-14 -2.46480878630153 3.72826186858018e-17 miRanda -0.446357676360982 8.37338314717128e-14 NA NA NA hsa-miR-660-5p LEPR 2.04875198906126 1.08269480928897e-17 -2.46480878630153 3.72826186858018e-17 MirTarget -0.277654021795153 1.32221087752773e-06 NA NA NA hsa-miR-7-1-3p LEPR 2.61364240402652 1.98959237815786e-32 -2.46480878630153 3.72826186858018e-17 mirMAP -0.425568261859368 3.22689247538491e-12 NA NA NA hsa-miR-30c-2-3p LIF -3.10905250533941 6.84550165664783e-27 0.724244426303863 0.0393011575470084 mirMAP -0.229577955861532 1.20593518456889e-05 NA NA NA hsa-miR-335-5p LIF -0.466533891325811 0.0676987038122831 0.724244426303863 0.0393011575470084 miRNAWalker2_validate;mirMAP -0.230141053675846 0.00119221242498461 NA NA NA hsa-miR-769-5p LIF 0.399593956787959 0.0122647297786293 0.724244426303863 0.0393011575470084 miRNATAP -0.270523707193606 0.00826316881203765 NA NA NA hsa-miR-136-5p LIFR 2.07553688303449 4.53553108822501e-09 -1.91304148064928 1.12145169149694e-12 mirMAP;miRNATAP -0.136369853705385 0.000104482181183464 NA NA NA hsa-miR-142-3p LIFR 3.98476449801341 1.56256182021111e-35 -1.91304148064928 1.12145169149694e-12 miRNATAP -0.262429761800315 2.13127641572235e-13 NA NA NA hsa-miR-142-5p LIFR 1.29672439149353 4.0768822158894e-06 -1.91304148064928 1.12145169149694e-12 PITA;mirMAP -0.174033758440078 0.000323076864674606 NA NA NA hsa-miR-203a-3p LIFR 1.06866854356847 0.00389979689199624 -1.91304148064928 1.12145169149694e-12 MirTarget -0.137262979401504 5.40746973777372e-05 NA NA NA hsa-miR-21-5p LIFR 4.38165933891779 1.52536633902505e-92 -1.91304148064928 1.12145169149694e-12 miRNAWalker2_validate -0.346683857713576 2.01433771532352e-13 NA NA NA hsa-miR-222-3p LIFR 0.0327210697409583 0.881937768109611 -1.91304148064928 1.12145169149694e-12 miRNATAP -0.239195962223386 3.32245259207403e-05 NA NA NA hsa-miR-23a-3p LIFR 0.111958289789488 0.393086414480463 -1.91304148064928 1.12145169149694e-12 mirMAP -0.443747277250365 5.93836145965968e-06 NA NA NA hsa-miR-27a-3p LIFR 0.433402568013802 0.00737164631768323 -1.91304148064928 1.12145169149694e-12 miRNAWalker2_validate;MirTarget;miRNATAP -0.364410630835107 3.4714169420003e-06 NA NA NA hsa-miR-29b-1-5p LIFR 1.71024742617744 3.64915691793611e-09 -1.91304148064928 1.12145169149694e-12 mirMAP -0.260619478465938 7.93836347942377e-10 NA NA NA hsa-miR-3607-3p LIFR 2.4103172144469 2.69039449048047e-08 -1.91304148064928 1.12145169149694e-12 mirMAP -0.16476359141314 6.69678976398182e-09 NA NA NA hsa-miR-409-3p LIFR 0.476201525793412 0.182989887810807 -1.91304148064928 1.12145169149694e-12 mirMAP -0.107301079383127 0.00248302267066221 NA NA NA hsa-miR-590-3p LIFR 0.83851360565783 0.00129224433453587 -1.91304148064928 1.12145169149694e-12 miRanda;mirMAP -0.186624196436028 0.00136058698885234 NA NA NA hsa-miR-590-5p LIFR 2.07441240363458 4.95240551694843e-14 -1.91304148064928 1.12145169149694e-12 PITA;miRNATAP -0.284640830863457 2.50303540895233e-07 NA NA NA hsa-miR-629-3p LIFR 1.31892116211001 0.000114487182853678 -1.91304148064928 1.12145169149694e-12 miRNATAP -0.190098013682536 1.7213454008251e-06 NA NA NA hsa-miR-7-1-3p LIFR 2.61364240402652 1.98959237815786e-32 -1.91304148064928 1.12145169149694e-12 mirMAP -0.333517903062412 2.41381463644934e-09 NA NA NA hsa-miR-708-3p LIFR 3.43841959417743 4.40027692981683e-28 -1.91304148064928 1.12145169149694e-12 mirMAP -0.240809295677934 1.07022175380482e-08 NA NA NA hsa-miR-128-3p MPL 1.03509868349735 2.11606310588315e-10 -0.605822958582755 0.00182640497387964 MirTarget -0.22255232815867 4.07655815350364e-05 NA NA NA hsa-miR-151a-5p MPL 1.23124135275661 2.93488020257558e-12 -0.605822958582755 0.00182640497387964 miRNAWalker2_validate;miRTarBase -0.197086824180706 7.62566045219385e-05 NA NA NA hsa-miR-708-3p MPL 3.43841959417743 4.40027692981683e-28 -0.605822958582755 0.00182640497387964 miRNAWalker2_validate;miRTarBase -0.127068750146773 2.26900208909775e-05 NA NA NA hsa-miR-708-5p MPL 3.04047795672813 3.01085192850869e-20 -0.605822958582755 0.00182640497387964 MirTarget -0.125130699604308 1.56214737436676e-05 NA NA NA hsa-miR-34a-5p MYC 1.40588612517769 8.60097477768592e-12 -0.594211476201249 0.0196490384548933 miRNAWalker2_validate;miRTarBase -0.160523406918217 0.0041257772904121 25572695;25686834;21460242;22159222;23640973;22830357;22235332 The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;miR 34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c Myc pathway;Myc mediated repression of microRNA 34a promotes high grade transformation of B cell lymphoma by dysregulation of FoxP1;MicroRNA 34a suppresses malignant transformation by targeting c Myc transcriptional complexes in human renal cell carcinoma; We investigated the functional effects of microRNA-34a miR-34a on c-Myc transcriptional complexes in renal cell carcinoma; miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region which was revealed by luciferase reporter assays; Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription indicating a novel role of miR-34a in the regulation of transcription by c-Myc;Among them miR-34a was also associated with poor prognosis in 2 independent series of leukemic and nodal MCL and in cooperation with high expression of the MYC oncogene;We report that miR-34a did not inhibit cell proliferation notwithstanding a marked down-regulation of c-MYC;MicroRNA 34a modulates c Myc transcriptional complexes to suppress malignancy in human prostate cancer cells; We studied the functional effects of miR-34a on c-Myc transcriptional complexes in PC-3 prostate cancer cells; miR-34a downregulated expression of c-Myc oncogene by targeting its 3' UTR as shown by luciferase reporter assays; This is the first report to document that miR-34a suppresses assembly and function of the c-Myc-Skp2-Miz1 complex that activates RhoA and the c-Myc-pTEFB complex that elongates transcription of various genes suggesting a novel role of miR-34a in the regulation of transcription by c-Myc complex ;;;malignant trasformation;worse prognosis;; bladder cancer;liver cancer;B cell lymphoma;kidney renal cell cancer;lymphoma;lymphoma;prostate cancer hsa-miR-429 MYC 2.3794516574089 1.72813419703734e-13 -0.594211476201249 0.0196490384548933 miRNAWalker2_validate -0.178099724014789 2.94573429210347e-06 21684154;24633485 miR 429 modulates the expression of c myc in human gastric carcinoma cells; SGC-7901 gastric cancer cells were transfected with miR-429 mimics and endogenous c-myc expression was detected by western blots; We performed functional assays using the 3'UTR of the c-myc gene as a miR-429 target in a luciferase reporter assay system; miR-429 significantly downregulated endogenous c-myc expression in SGC-7901 cells; Action of miR/429 on c-myc 3'UTR was confirmed; c-myc is an important miR-429 target gene;It is known that miR-429 is down-regulated and functions as a tumor suppressor by targeting c-myc and PLGG1 in gastric and breast cancer ; gastric cancer;sarcoma hsa-let-7d-5p OSMR -0.618145137285851 6.06067642715858e-05 0.385733591661532 0.111305646356038 miRNATAP -0.238108335434953 0.00102596833714279 NA NA NA hsa-miR-200b-3p OSMR 1.55157578247391 4.83790020897188e-09 0.385733591661532 0.111305646356038 TargetScan -0.236637153283022 6.93498025718709e-09 NA NA NA hsa-miR-335-5p OSMR -0.466533891325811 0.0676987038122831 0.385733591661532 0.111305646356038 miRNAWalker2_validate -0.261341914939051 6.67044843056893e-08 NA NA NA hsa-miR-362-3p OSMR 0.194097672030785 0.52808475179225 0.385733591661532 0.111305646356038 miRanda -0.130833842741225 0.00394947318108139 NA NA NA hsa-miR-374a-5p OSMR -0.197027254874826 0.298080902192861 0.385733591661532 0.111305646356038 mirMAP -0.248474817094483 0.000176395395777012 NA NA NA hsa-miR-374b-5p OSMR 0.474691035780475 0.0109217471394203 0.385733591661532 0.111305646356038 mirMAP -0.230294109982855 0.00026780473354388 NA NA NA hsa-miR-429 OSMR 2.3794516574089 1.72813419703734e-13 0.385733591661532 0.111305646356038 miRanda;miRNATAP -0.212394940517193 3.37736358234996e-09 NA NA NA hsa-miR-342-3p PIAS1 -0.128691966564961 0.561034080130801 -0.802738096841587 1.61398055398725e-13 miRanda -0.106607224705817 3.92580325062181e-06 NA NA NA hsa-miR-96-5p PIAS1 3.0381097138467 4.40362891630201e-24 -0.802738096841587 1.61398055398725e-13 TargetScan -0.169805306725073 2.98190566466177e-21 NA NA NA hsa-miR-181a-5p PIAS2 -0.375429731222937 0.0562142867129802 -0.173884437252488 0.263333436884774 mirMAP -0.14379600537777 7.57798196587579e-05 NA NA NA hsa-miR-181b-5p PIAS2 0.668793269169928 0.000239998092406404 -0.173884437252488 0.263333436884774 mirMAP -0.15506178212724 7.27224766831485e-05 NA NA NA hsa-miR-497-5p PIAS2 -0.0546347378264729 0.786205564901684 -0.173884437252488 0.263333436884774 MirTarget -0.103820917780467 0.00359755349644897 NA NA NA hsa-let-7a-5p PIAS4 -1.37014061604018 3.11451492971224e-14 0.0930976487379929 0.384714219903101 TargetScan -0.150667795496077 9.10459782235738e-09 NA NA NA hsa-miR-186-5p PIK3CA 0.852175445703945 6.88885738584309e-10 -0.335143841150832 0.0107695904000801 mirMAP -0.158211833933772 0.000271764939125213 NA NA NA hsa-miR-501-5p PIK3CA 0.411357595674671 0.10435288464149 -0.335143841150832 0.0107695904000801 mirMAP -0.12161859871495 2.80222388365699e-07 NA NA NA hsa-miR-96-5p PIK3CA 3.0381097138467 4.40362891630201e-24 -0.335143841150832 0.0107695904000801 TargetScan -0.126074442438012 7.26672594996813e-09 NA NA NA hsa-miR-454-3p PIK3CB 1.49453641052169 4.46235742871434e-09 0.0520424688078016 0.708498300848208 miRNATAP -0.107092855274913 0.000279808925292599 NA NA NA hsa-miR-421 PIK3CD 0.170525317701774 0.535277026680289 -0.165252183051274 0.400815192488832 miRanda -0.187035284767016 1.2803934448503e-07 NA NA NA hsa-miR-148b-3p PIK3CG 0.483970528590224 0.0026495409465901 -1.19325793461087 5.28114748039233e-05 miRNAWalker2_validate -0.239430332797948 0.00515332606189168 NA NA NA hsa-miR-26b-5p PIK3CG 0.72362441215247 4.7794659748036e-05 -1.19325793461087 5.28114748039233e-05 miRNAWalker2_validate -0.285401672500096 0.000198071700272844 NA NA NA hsa-miR-29b-3p PIK3CG 3.10527711861309 3.01242507282711e-32 -1.19325793461087 5.28114748039233e-05 miRTarBase -0.13454994451672 0.00563635188925694 NA NA NA hsa-miR-335-3p PIK3CG 1.51116383169018 6.88553098788624e-13 -1.19325793461087 5.28114748039233e-05 mirMAP -0.273824058387904 1.51960031354635e-05 NA NA NA hsa-miR-542-3p PIK3CG 1.62226640768239 2.6427102465476e-10 -1.19325793461087 5.28114748039233e-05 miRanda -0.188110029792226 0.000315799878113487 NA NA NA hsa-miR-106a-5p PIK3R1 1.3902608059488 6.07931522284525e-05 -1.28526113405546 1.1596112892202e-14 MirTarget;miRNATAP -0.152594260668069 8.26964346589391e-10 NA NA NA hsa-miR-106b-5p PIK3R1 1.47447672652218 1.32004094930462e-13 -1.28526113405546 1.1596112892202e-14 MirTarget;miRNATAP -0.274486784039244 3.92361901886501e-13 NA NA NA hsa-miR-128-3p PIK3R1 1.03509868349735 2.11606310588315e-10 -1.28526113405546 1.1596112892202e-14 MirTarget -0.262733562571172 2.81828198129055e-08 25962360 miR 128 3p suppresses hepatocellular carcinoma proliferation by regulating PIK3R1 and is correlated with the prognosis of HCC patients; Mechanistically miR-128-3p was confirmed to regulate PIK3R1 p85α expression thereby suppressing phosphatidylinositol 3-kinase PI3K/AKT pathway activation using qRT-PCR and western blot analysis; Hence we conclude that miR-128-3p which is frequently downregulated in HCC inhibits HCC progression by regulating PIK3R1 and PI3K/AKT activation and is a prognostic marker for HCC patients worse prognosis;progression liver cancer hsa-miR-1301-3p PIK3R1 0.845987603184611 0.000579808501723616 -1.28526113405546 1.1596112892202e-14 MirTarget -0.252566507630763 3.89638206850943e-16 NA NA NA hsa-miR-15a-5p PIK3R1 1.62575353599172 1.55312121019827e-19 -1.28526113405546 1.1596112892202e-14 MirTarget -0.198845640675418 2.2459439580454e-06 NA NA NA hsa-miR-16-2-3p PIK3R1 0.503964803530872 0.0263648405197492 -1.28526113405546 1.1596112892202e-14 MirTarget -0.215346374588015 7.85659740371802e-09 NA NA NA hsa-miR-16-5p PIK3R1 0.749619098384047 4.11649450706988e-06 -1.28526113405546 1.1596112892202e-14 MirTarget -0.14663084031301 0.00245632583144358 NA NA NA hsa-miR-17-5p PIK3R1 2.07078488653279 2.77403038572568e-19 -1.28526113405546 1.1596112892202e-14 MirTarget;TargetScan;miRNATAP -0.30827377198364 1.00416866782136e-22 NA NA NA hsa-miR-182-5p PIK3R1 3.21839823004635 5.13049145201115e-39 -1.28526113405546 1.1596112892202e-14 miRNATAP -0.153577568348738 1.31399000956901e-07 NA NA NA hsa-miR-185-5p PIK3R1 1.14291034858482 2.95777119743491e-13 -1.28526113405546 1.1596112892202e-14 miRNATAP -0.266123472564886 5.49627003455298e-08 NA NA NA hsa-miR-186-5p PIK3R1 0.852175445703945 6.88885738584309e-10 -1.28526113405546 1.1596112892202e-14 mirMAP -0.266496146428416 2.3226235073163e-06 NA NA NA hsa-miR-200c-3p PIK3R1 0.380533388300368 0.0842181838538353 -1.28526113405546 1.1596112892202e-14 mirMAP -0.174738637328334 9.22364461849854e-07 NA NA NA hsa-miR-20a-5p PIK3R1 2.64649625616975 5.1469418982085e-27 -1.28526113405546 1.1596112892202e-14 MirTarget;miRNATAP -0.268255645046992 2.93530513676098e-20 NA NA NA hsa-miR-21-5p PIK3R1 4.38165933891779 1.52536633902505e-92 -1.28526113405546 1.1596112892202e-14 miRNAWalker2_validate;MirTarget;miRNATAP -0.239855941401679 1.66617444081141e-16 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-22-5p PIK3R1 1.71436244278242 9.85038001236064e-15 -1.28526113405546 1.1596112892202e-14 mirMAP -0.249170402831725 1.77307790115702e-13 NA NA NA hsa-miR-29b-3p PIK3R1 3.10527711861309 3.01242507282711e-32 -1.28526113405546 1.1596112892202e-14 MirTarget;miRNATAP -0.169264704761152 8.1620915503371e-10 NA NA NA hsa-miR-335-3p PIK3R1 1.51116383169018 6.88553098788624e-13 -1.28526113405546 1.1596112892202e-14 mirMAP -0.174731000503181 1.56931158200611e-06 NA NA NA hsa-miR-424-5p PIK3R1 1.26485330287919 6.1498991028257e-06 -1.28526113405546 1.1596112892202e-14 MirTarget -0.120660860108298 1.41199550729587e-05 NA NA NA hsa-miR-450b-5p PIK3R1 1.69248953402469 1.96052058003353e-07 -1.28526113405546 1.1596112892202e-14 miRNATAP -0.105483872062601 7.60035078150308e-05 NA NA NA hsa-miR-582-5p PIK3R1 1.08286181406653 0.00149040450161757 -1.28526113405546 1.1596112892202e-14 mirMAP -0.121659359408152 1.98808465862233e-07 NA NA NA hsa-miR-589-3p PIK3R1 1.34253876396688 1.84935927493927e-05 -1.28526113405546 1.1596112892202e-14 mirMAP -0.110115880585781 1.73041185531321e-05 NA NA NA hsa-miR-590-3p PIK3R1 0.83851360565783 0.00129224433453587 -1.28526113405546 1.1596112892202e-14 miRanda;mirMAP -0.21433969556349 1.93094554722457e-09 NA NA NA hsa-miR-590-5p PIK3R1 2.07441240363458 4.95240551694843e-14 -1.28526113405546 1.1596112892202e-14 MirTarget;PITA;miRanda;miRNATAP -0.297606057222883 4.39734655384069e-19 NA NA NA hsa-miR-629-3p PIK3R1 1.31892116211001 0.000114487182853678 -1.28526113405546 1.1596112892202e-14 MirTarget -0.155200085033098 2.2200629415611e-10 NA NA NA hsa-miR-93-5p PIK3R1 1.50844106515467 1.83836866996875e-12 -1.28526113405546 1.1596112892202e-14 MirTarget;miRNATAP -0.302548872464343 3.62432128460294e-18 NA NA NA hsa-miR-96-5p PIK3R1 3.0381097138467 4.40362891630201e-24 -1.28526113405546 1.1596112892202e-14 TargetScan;miRNATAP -0.247820034174453 4.28366535969023e-19 NA NA NA hsa-miR-29b-1-5p PIK3R3 1.71024742617744 3.64915691793611e-09 -0.993075734580867 1.37876508579496e-06 mirMAP -0.137607471527013 2.02669327816331e-05 NA NA NA hsa-miR-335-3p PIK3R3 1.51116383169018 6.88553098788624e-13 -0.993075734580867 1.37876508579496e-06 mirMAP -0.239450639911665 5.21180596069304e-08 NA NA NA hsa-miR-107 PIK3R5 0.658676029898313 5.11480446318819e-07 -1.41857329052665 4.9150449517908e-09 miRanda -0.303365993068523 0.000471196296141979 NA NA NA hsa-miR-182-5p PIK3R5 3.21839823004635 5.13049145201115e-39 -1.41857329052665 4.9150449517908e-09 MirTarget -0.327566926397612 1.58877421029473e-15 NA NA NA hsa-miR-181a-5p PTPN11 -0.375429731222937 0.0562142867129802 -0.313926759091373 0.014358000979233 miRNAWalker2_validate;miRTarBase -0.205098363361928 3.55425058791527e-12 NA NA NA hsa-miR-186-5p PTPN11 0.852175445703945 6.88885738584309e-10 -0.313926759091373 0.014358000979233 mirMAP -0.166059774368664 8.74675396568392e-05 NA NA NA hsa-miR-28-5p PTPN11 1.19639196514745 4.59365801666536e-18 -0.313926759091373 0.014358000979233 miRanda -0.118441806126089 0.00448101443885386 NA NA NA hsa-miR-30d-3p PTPN11 0.00396376345349925 0.986457040013182 -0.313926759091373 0.014358000979233 mirMAP -0.119423879568279 2.4036932971846e-05 NA NA NA hsa-miR-30e-3p PTPN11 -0.104420043859122 0.526240453209293 -0.313926759091373 0.014358000979233 mirMAP -0.151019925354087 2.70098934287585e-05 NA NA NA hsa-miR-429 PTPN11 2.3794516574089 1.72813419703734e-13 -0.313926759091373 0.014358000979233 miRNATAP -0.105487532163286 3.01671898839701e-08 NA NA NA hsa-miR-455-5p PTPN11 1.36946341828134 5.05118627562807e-08 -0.313926759091373 0.014358000979233 miRanda -0.123759622736364 3.28445477193252e-06 NA NA NA hsa-miR-660-5p PTPN11 2.04875198906126 1.08269480928897e-17 -0.313926759091373 0.014358000979233 mirMAP -0.125682579233685 2.01541941486471e-07 NA NA NA hsa-miR-130b-5p SOCS2 1.53645187062942 1.10498816261505e-08 -2.22692863592047 1.45695682683411e-13 miRNATAP -0.275000393113122 1.03946021565959e-07 NA NA NA hsa-miR-25-3p SOCS2 0.361927330834176 0.0163670566170988 -2.22692863592047 1.45695682683411e-13 mirMAP -0.357624585885314 0.000173939939925742 NA NA NA hsa-miR-421 SOCS2 0.170525317701774 0.535277026680289 -2.22692863592047 1.45695682683411e-13 miRanda -0.177963964590949 0.00160517013470952 NA NA NA hsa-miR-429 SOCS2 2.3794516574089 1.72813419703734e-13 -2.22692863592047 1.45695682683411e-13 miRNATAP -0.173426728850613 0.00018974091932658 NA NA NA hsa-miR-576-5p SOCS2 1.02693643167056 1.14846964470173e-06 -2.22692863592047 1.45695682683411e-13 PITA -0.210151089711104 0.0017128379338042 NA NA NA hsa-miR-7-1-3p SOCS2 2.61364240402652 1.98959237815786e-32 -2.22692863592047 1.45695682683411e-13 mirMAP -0.388851694021288 5.50423498478692e-10 NA NA NA hsa-miR-7-5p SOCS2 0.343825848926135 0.435063427976906 -2.22692863592047 1.45695682683411e-13 miRNAWalker2_validate;miRNATAP -0.148258839058522 0.000235200544343285 NA NA NA hsa-miR-940 SOCS2 0.011138136211269 0.974925352379525 -2.22692863592047 1.45695682683411e-13 miRNATAP -0.133481775076573 0.0031664285342872 NA NA NA hsa-miR-130b-5p SOCS3 1.53645187062942 1.10498816261505e-08 -1.40534383103986 2.2830335763797e-09 mirMAP -0.106159529901002 0.00857344178365919 NA NA NA hsa-miR-125b-5p SOCS4 -0.548859243919575 0.0107224406584463 -0.0112885249073269 0.915340533328072 miRNATAP -0.112924950880981 4.715174135686e-07 NA NA NA hsa-miR-140-3p SOCS4 -1.11373309124537 8.35257079443689e-14 -0.0112885249073269 0.915340533328072 PITA;miRNATAP -0.131853795858169 3.52586138513074e-05 NA NA NA hsa-miR-34a-5p SOCS4 1.40588612517769 8.60097477768592e-12 -0.0112885249073269 0.915340533328072 miRNAWalker2_validate;miRNATAP -0.120464877538801 1.45963325082517e-07 NA NA NA hsa-miR-664a-3p SOCS4 0.443077463053857 0.0214248925850984 -0.0112885249073269 0.915340533328072 mirMAP -0.110099869650307 1.23080827486418e-05 NA NA NA hsa-miR-16-5p SOCS5 0.749619098384047 4.11649450706988e-06 -0.44143597114066 3.96474821502192e-05 miRNAWalker2_validate -0.105960110768254 0.000489401778731672 NA NA NA hsa-miR-342-3p SOCS5 -0.128691966564961 0.561034080130801 -0.44143597114066 3.96474821502192e-05 miRanda -0.147201982248916 2.59516795833711e-11 NA NA NA hsa-miR-590-5p SOCS5 2.07441240363458 4.95240551694843e-14 -0.44143597114066 3.96474821502192e-05 miRanda -0.141327735215034 3.68102904698996e-11 NA NA NA hsa-miR-7-1-3p SOCS5 2.61364240402652 1.98959237815786e-32 -0.44143597114066 3.96474821502192e-05 mirMAP -0.109562242831487 6.01943152500503e-07 NA NA NA hsa-miR-140-5p SOCS7 0.669142684153918 0.000335928403032308 -0.258232698932216 0.211392210749282 miRNATAP -0.193158435696236 0.000212894999145491 NA NA NA hsa-miR-181a-5p SOS1 -0.375429731222937 0.0562142867129802 0.0798852744327974 0.432914353979627 MirTarget;miRNATAP -0.10469236503224 9.69385315635354e-06 NA NA NA hsa-miR-26a-2-3p SOS1 0.264287787772609 0.305653616292982 0.0798852744327974 0.432914353979627 mirMAP -0.11755820325968 1.45592951814447e-07 NA NA NA hsa-miR-30b-5p SOS1 0.358144314839612 0.138026229059594 0.0798852744327974 0.432914353979627 mirMAP -0.100738601906088 1.42009312360891e-07 NA NA NA hsa-miR-30c-5p SOS1 -0.327319105755825 0.123595832152687 0.0798852744327974 0.432914353979627 mirMAP;miRNATAP -0.118113245139624 5.71228815703205e-08 NA NA NA hsa-miR-664a-3p SOS1 0.443077463053857 0.0214248925850984 0.0798852744327974 0.432914353979627 mirMAP -0.10862184907092 6.79471781102034e-06 NA NA NA hsa-miR-103a-3p SPRED1 0.538497806383155 1.88134691850591e-05 -0.494311600962025 0.0048335448827958 miRNAWalker2_validate -0.175454813326562 0.00691767458967306 NA NA NA hsa-miR-106a-5p SPRED1 1.3902608059488 6.07931522284525e-05 -0.494311600962025 0.0048335448827958 miRNATAP -0.219757585271601 1.31958285432813e-18 NA NA NA hsa-miR-106b-5p SPRED1 1.47447672652218 1.32004094930462e-13 -0.494311600962025 0.0048335448827958 miRNATAP -0.286309165056013 1.46980827485631e-13 NA NA NA hsa-miR-107 SPRED1 0.658676029898313 5.11480446318819e-07 -0.494311600962025 0.0048335448827958 miRanda -0.222643729982769 0.000315320390478842 NA NA NA hsa-miR-126-3p SPRED1 0.397563736477277 0.115641762947829 -0.494311600962025 0.0048335448827958 miRNAWalker2_validate;miRTarBase;miRNATAP -0.164098854550423 2.36961675434717e-07 NA NA NA hsa-miR-130a-3p SPRED1 0.881660100597014 0.000158893668519248 -0.494311600962025 0.0048335448827958 miRNATAP -0.174121461768329 3.56679751579892e-07 NA NA NA hsa-miR-130b-3p SPRED1 1.83046548750752 5.04753914574694e-13 -0.494311600962025 0.0048335448827958 miRNATAP -0.200149482292787 5.96245299431701e-10 NA NA NA hsa-miR-141-3p SPRED1 3.36993755486106 5.42939251147195e-32 -0.494311600962025 0.0048335448827958 miRNATAP -0.222970305687497 1.6654505434226e-18 NA NA NA hsa-miR-15a-5p SPRED1 1.62575353599172 1.55312121019827e-19 -0.494311600962025 0.0048335448827958 miRNATAP -0.172017405071707 7.00776023580066e-05 NA NA NA hsa-miR-15b-5p SPRED1 -1.25935038177398 1.83460220856901e-12 -0.494311600962025 0.0048335448827958 miRNATAP -0.142366437768694 0.00134717482096105 NA NA NA hsa-miR-16-1-3p SPRED1 1.50034693398929 6.63958242991125e-10 -0.494311600962025 0.0048335448827958 mirMAP -0.157875853668389 9.9592280457553e-05 NA NA NA hsa-miR-16-5p SPRED1 0.749619098384047 4.11649450706988e-06 -0.494311600962025 0.0048335448827958 miRNAWalker2_validate;miRNATAP -0.179254688409174 0.00029696785778991 NA NA NA hsa-miR-17-5p SPRED1 2.07078488653279 2.77403038572568e-19 -0.494311600962025 0.0048335448827958 TargetScan;miRNATAP -0.347416501700243 1.04028755280817e-27 NA NA NA hsa-miR-183-5p SPRED1 2.39247234736657 3.92444525331999e-21 -0.494311600962025 0.0048335448827958 miRNATAP -0.123543333487904 4.81904851544823e-05 NA NA NA hsa-miR-200a-3p SPRED1 3.14766878548496 1.32850889777422e-21 -0.494311600962025 0.0048335448827958 miRNATAP -0.147648411818624 4.14594575019555e-10 NA NA NA hsa-miR-200b-3p SPRED1 1.55157578247391 4.83790020897188e-09 -0.494311600962025 0.0048335448827958 TargetScan -0.120894080531514 5.30228183182451e-05 NA NA NA hsa-miR-200c-3p SPRED1 0.380533388300368 0.0842181838538353 -0.494311600962025 0.0048335448827958 miRNATAP -0.232810902338573 1.23870899345331e-10 NA NA NA hsa-miR-20a-5p SPRED1 2.64649625616975 5.1469418982085e-27 -0.494311600962025 0.0048335448827958 miRNATAP -0.281920383168561 2.7203648046474e-21 NA NA NA hsa-miR-20b-5p SPRED1 1.35770573270947 0.00260808530013016 -0.494311600962025 0.0048335448827958 miRNATAP -0.152542006249821 5.65891036066934e-17 NA NA NA hsa-miR-25-3p SPRED1 0.361927330834176 0.0163670566170988 -0.494311600962025 0.0048335448827958 mirMAP -0.258665146444539 1.50736562056944e-06 NA NA NA hsa-miR-26b-5p SPRED1 0.72362441215247 4.7794659748036e-05 -0.494311600962025 0.0048335448827958 miRNATAP -0.228099639718823 4.07015290051415e-07 NA NA NA hsa-miR-301a-3p SPRED1 2.70198002906399 1.56420889710984e-14 -0.494311600962025 0.0048335448827958 miRNATAP -0.195658015522053 4.72271554991429e-13 NA NA NA hsa-miR-32-5p SPRED1 0.876853679269853 6.04859399018691e-05 -0.494311600962025 0.0048335448827958 mirMAP -0.207070460559728 1.74307452144568e-07 NA NA NA hsa-miR-335-3p SPRED1 1.51116383169018 6.88553098788624e-13 -0.494311600962025 0.0048335448827958 mirMAP -0.136816486648806 0.00026469905125798 NA NA NA hsa-miR-363-3p SPRED1 -0.301366430789287 0.414451883803084 -0.494311600962025 0.0048335448827958 mirMAP -0.138299231607188 1.50719374914649e-10 NA NA NA hsa-miR-374b-5p SPRED1 0.474691035780475 0.0109217471394203 -0.494311600962025 0.0048335448827958 mirMAP -0.186784690872902 4.46742886150432e-05 NA NA NA hsa-miR-429 SPRED1 2.3794516574089 1.72813419703734e-13 -0.494311600962025 0.0048335448827958 miRNATAP -0.145277727661625 2.66470866066993e-08 NA NA NA hsa-miR-454-3p SPRED1 1.49453641052169 4.46235742871434e-09 -0.494311600962025 0.0048335448827958 miRNATAP -0.310910168597415 8.28224840075504e-18 NA NA NA hsa-miR-500a-5p SPRED1 0.648155655714409 0.0104657432932038 -0.494311600962025 0.0048335448827958 mirMAP -0.193276697505158 2.26776160962156e-09 NA NA NA hsa-miR-589-3p SPRED1 1.34253876396688 1.84935927493927e-05 -0.494311600962025 0.0048335448827958 mirMAP -0.132928127069541 3.81521967779661e-07 NA NA NA hsa-miR-590-3p SPRED1 0.83851360565783 0.00129224433453587 -0.494311600962025 0.0048335448827958 miRanda;mirMAP -0.20462323758893 2.48916678401195e-08 NA NA NA hsa-miR-92a-3p SPRED1 -0.136362762339122 0.493412263619364 -0.494311600962025 0.0048335448827958 mirMAP -0.26926740210561 1.8618971379803e-11 NA NA NA hsa-miR-92b-3p SPRED1 0.0478787637665503 0.831716894621477 -0.494311600962025 0.0048335448827958 mirMAP -0.103445885261503 0.0041256235045301 NA NA NA hsa-miR-93-3p SPRED1 1.07631808403007 1.63747525692813e-05 -0.494311600962025 0.0048335448827958 miRNATAP -0.266977055368892 8.6158089020166e-18 NA NA NA hsa-miR-93-5p SPRED1 1.50844106515467 1.83836866996875e-12 -0.494311600962025 0.0048335448827958 miRNAWalker2_validate;miRNATAP -0.334218585456871 4.26503974950579e-21 NA NA NA hsa-miR-106a-5p SPRED2 1.3902608059488 6.07931522284525e-05 -0.145099938440564 0.344667722538088 mirMAP -0.116711990446964 1.73550201076347e-07 NA NA NA hsa-miR-106b-5p SPRED2 1.47447672652218 1.32004094930462e-13 -0.145099938440564 0.344667722538088 mirMAP -0.146744589990857 2.01434778904306e-05 NA NA NA hsa-miR-142-5p SPRED2 1.29672439149353 4.0768822158894e-06 -0.145099938440564 0.344667722538088 mirMAP -0.134454641383734 4.71178668884375e-07 NA NA NA hsa-miR-17-5p SPRED2 2.07078488653279 2.77403038572568e-19 -0.145099938440564 0.344667722538088 mirMAP -0.160308318548339 3.47804445019806e-08 NA NA NA hsa-miR-186-5p SPRED2 0.852175445703945 6.88885738584309e-10 -0.145099938440564 0.344667722538088 miRNAWalker2_validate -0.234638350343842 3.29594220340671e-06 NA NA NA hsa-miR-20a-5p SPRED2 2.64649625616975 5.1469418982085e-27 -0.145099938440564 0.344667722538088 mirMAP -0.12570305764964 2.90969982903497e-06 NA NA NA hsa-miR-320b SPRED2 0.226640952564488 0.378818692487242 -0.145099938440564 0.344667722538088 PITA;miRanda;miRNATAP -0.100900641150851 0.000226410636922157 NA NA NA hsa-miR-421 SPRED2 0.170525317701774 0.535277026680289 -0.145099938440564 0.344667722538088 miRanda -0.159590868908756 6.78509613331265e-09 NA NA NA hsa-miR-590-5p SPRED2 2.07441240363458 4.95240551694843e-14 -0.145099938440564 0.344667722538088 miRanda -0.199388058065023 5.21300200713181e-11 NA NA NA hsa-miR-93-5p SPRED2 1.50844106515467 1.83836866996875e-12 -0.145099938440564 0.344667722538088 mirMAP -0.180884563057386 1.32464243315447e-08 NA NA NA hsa-miR-142-5p SPRY1 1.29672439149353 4.0768822158894e-06 -0.842495704439272 5.61559400130424e-06 miRNATAP -0.127208314202894 0.00010537885220913 NA NA NA hsa-miR-16-2-3p SPRY1 0.503964803530872 0.0263648405197492 -0.842495704439272 5.61559400130424e-06 mirMAP -0.27284398981022 1.61874279670462e-11 NA NA NA hsa-miR-20a-3p SPRY1 2.51803599558247 4.92479325298629e-13 -0.842495704439272 5.61559400130424e-06 miRNATAP -0.1457088087895 2.44320477223988e-06 NA NA NA hsa-miR-21-5p SPRY1 4.38165933891779 1.52536633902505e-92 -0.842495704439272 5.61559400130424e-06 miRNATAP -0.169221056632968 1.87839009680652e-07 24155920 Functional studies showed that miR-21 over-expression in GICs induced comparable cell differentiation features and targeted SPRY1 mRNA which encodes for a negative regulator of neural stem-cell differentiation differentiation glioblastoma hsa-miR-29b-3p SPRY1 3.10527711861309 3.01242507282711e-32 -0.842495704439272 5.61559400130424e-06 miRNATAP -0.146580368569028 1.35295720774822e-06 NA NA NA hsa-miR-421 SPRY1 0.170525317701774 0.535277026680289 -0.842495704439272 5.61559400130424e-06 PITA;miRanda;miRNATAP -0.141053684006765 3.25437547273814e-05 NA NA NA hsa-miR-550a-3p SPRY1 0.0186193291188046 0.949896722138275 -0.842495704439272 5.61559400130424e-06 miRNATAP -0.114387701444472 0.000136490836027269 NA NA NA hsa-miR-590-5p SPRY1 2.07441240363458 4.95240551694843e-14 -0.842495704439272 5.61559400130424e-06 PITA;miRanda;miRNATAP -0.248498971675039 2.08679223712643e-11 NA NA NA hsa-miR-148a-3p SPRY2 2.30885799126944 1.95226081368985e-21 -0.977623105588266 2.21329948488015e-07 miRNAWalker2_validate -0.137928579206572 6.40278365893818e-05 NA NA NA hsa-miR-21-5p SPRY2 4.38165933891779 1.52536633902505e-92 -0.977623105588266 2.21329948488015e-07 miRNAWalker2_validate;miRTarBase;miRNATAP -0.15366732752538 3.78204629369481e-06 22322462 Inhibition of microRNA-21 mir‑21 induced upregulation of Spry2 and PTEN which underscores the importance of mir-21 in Spry2-associated tumorigenesis of the colon tumorigenesis colon cancer hsa-miR-330-5p SPRY2 0.168520831101569 0.336433937906706 -0.977623105588266 2.21329948488015e-07 miRanda;miRNATAP -0.146475901666056 0.00378388091463353 NA NA NA hsa-miR-590-3p SPRY2 0.83851360565783 0.00129224433453587 -0.977623105588266 2.21329948488015e-07 PITA;miRanda;mirMAP;miRNATAP -0.219538884367272 3.81195879493377e-08 NA NA NA hsa-miR-590-5p SPRY2 2.07441240363458 4.95240551694843e-14 -0.977623105588266 2.21329948488015e-07 PITA;miRanda;miRNATAP -0.299171058077034 1.42707451996589e-15 NA NA NA hsa-miR-335-3p SPRY3 1.51116383169018 6.88553098788624e-13 0.033457161799894 0.887272532126055 mirMAP -0.133962504832585 0.00794824055233258 NA NA NA hsa-miR-338-5p SPRY3 -1.83316380675941 4.03269924759167e-07 0.033457161799894 0.887272532126055 mirMAP -0.116602346495401 7.61186269839927e-05 NA NA NA hsa-miR-3614-5p SPRY3 -1.19394699210224 2.53933783780868e-05 0.033457161799894 0.887272532126055 mirMAP;miRNATAP -0.114978427062686 0.00250831960459587 NA NA NA hsa-miR-106a-5p SPRY4 1.3902608059488 6.07931522284525e-05 -1.26334554012998 3.25375042707985e-08 miRNATAP -0.185531681337076 3.95259563040626e-08 NA NA NA hsa-miR-106b-5p SPRY4 1.47447672652218 1.32004094930462e-13 -1.26334554012998 3.25375042707985e-08 miRNATAP -0.376600668240066 1.79976473765615e-13 NA NA NA hsa-miR-130b-3p SPRY4 1.83046548750752 5.04753914574694e-13 -1.26334554012998 3.25375042707985e-08 mirMAP -0.291865777294588 6.30829843917326e-12 NA NA NA hsa-miR-141-3p SPRY4 3.36993755486106 5.42939251147195e-32 -1.26334554012998 3.25375042707985e-08 TargetScan;miRNATAP -0.210108360415661 8.32663468237438e-10 NA NA NA hsa-miR-142-5p SPRY4 1.29672439149353 4.0768822158894e-06 -1.26334554012998 3.25375042707985e-08 mirMAP -0.206291450281372 3.30743487035937e-07 NA NA NA hsa-miR-148b-5p SPRY4 1.39335695292409 2.13220380550073e-07 -1.26334554012998 3.25375042707985e-08 mirMAP -0.290524027168501 3.88640580921506e-10 NA NA NA hsa-miR-15a-5p SPRY4 1.62575353599172 1.55312121019827e-19 -1.26334554012998 3.25375042707985e-08 miRNATAP -0.164731676790762 0.00406391525145136 NA NA NA hsa-miR-16-2-3p SPRY4 0.503964803530872 0.0263648405197492 -1.26334554012998 3.25375042707985e-08 mirMAP -0.212604769796376 2.99053928588947e-05 NA NA NA hsa-miR-16-5p SPRY4 0.749619098384047 4.11649450706988e-06 -1.26334554012998 3.25375042707985e-08 miRNATAP -0.274131538144085 2.64489336223491e-05 NA NA NA hsa-miR-17-5p SPRY4 2.07078488653279 2.77403038572568e-19 -1.26334554012998 3.25375042707985e-08 TargetScan;miRNATAP -0.297420134560438 9.51859862736934e-12 NA NA NA hsa-miR-182-5p SPRY4 3.21839823004635 5.13049145201115e-39 -1.26334554012998 3.25375042707985e-08 miRNATAP -0.161213943539205 4.74683530526456e-05 NA NA NA hsa-miR-192-5p SPRY4 2.03412119423736 1.6357945826287e-05 -1.26334554012998 3.25375042707985e-08 miRNAWalker2_validate -0.113274938890997 3.22118473111015e-07 NA NA NA hsa-miR-20a-5p SPRY4 2.64649625616975 5.1469418982085e-27 -1.26334554012998 3.25375042707985e-08 miRNATAP -0.241936503812858 2.12917093639305e-09 NA NA NA hsa-miR-20b-5p SPRY4 1.35770573270947 0.00260808530013016 -1.26334554012998 3.25375042707985e-08 miRNATAP -0.119280128021165 1.30257940918839e-06 NA NA NA hsa-miR-29b-3p SPRY4 3.10527711861309 3.01242507282711e-32 -1.26334554012998 3.25375042707985e-08 miRNATAP -0.13974712590298 0.000216810830463393 NA NA NA hsa-miR-320b SPRY4 0.226640952564488 0.378818692487242 -1.26334554012998 3.25375042707985e-08 mirMAP -0.138403073163835 0.000852387207666138 NA NA NA hsa-miR-424-5p SPRY4 1.26485330287919 6.1498991028257e-06 -1.26334554012998 3.25375042707985e-08 miRNATAP -0.15670241404117 3.14751991927798e-05 NA NA NA hsa-miR-450b-5p SPRY4 1.69248953402469 1.96052058003353e-07 -1.26334554012998 3.25375042707985e-08 mirMAP;miRNATAP -0.100845751291312 0.00538956869317744 NA NA NA hsa-miR-454-3p SPRY4 1.49453641052169 4.46235742871434e-09 -1.26334554012998 3.25375042707985e-08 miRNATAP -0.218483465322764 8.68013401933343e-06 NA NA NA hsa-miR-590-5p SPRY4 2.07441240363458 4.95240551694843e-14 -1.26334554012998 3.25375042707985e-08 PITA;miRNATAP -0.385527333257171 1.72926411383992e-17 NA NA NA hsa-miR-7-1-3p SPRY4 2.61364240402652 1.98959237815786e-32 -1.26334554012998 3.25375042707985e-08 mirMAP -0.310866896648553 3.03867550087862e-11 NA NA NA hsa-miR-93-5p SPRY4 1.50844106515467 1.83836866996875e-12 -1.26334554012998 3.25375042707985e-08 miRNATAP -0.348124365948821 2.84252474360588e-13 NA NA NA hsa-miR-199a-5p STAM 1.3057193856884 2.38429382751645e-08 -0.3785779029553 0.00103143501875727 miRanda -0.12182502052398 3.87622664594372e-08 NA NA NA hsa-miR-199b-5p STAM 2.13822205171062 4.56262988762436e-15 -0.3785779029553 0.00103143501875727 miRanda -0.10829367018629 6.27657203032146e-09 NA NA NA hsa-miR-664a-3p STAM 0.443077463053857 0.0214248925850984 -0.3785779029553 0.00103143501875727 MirTarget -0.122508322034224 8.58775355647482e-06 NA NA NA hsa-miR-145-5p STAT1 -1.34926078156437 2.63526538800669e-07 0.587079317807589 0.00440158973867969 miRNAWalker2_validate;miRTarBase -0.115691295095518 0.00124680132395165 20098684 MicroRNA 145 targets YES and STAT1 in colon cancer cells; Both YES and STAT1 were verified as direct miR-145 targets colon cancer hsa-let-7a-5p STAT2 -1.37014061604018 3.11451492971224e-14 0.509864514303379 1.40678909724171e-05 MirTarget -0.156629222652638 7.44352688737886e-08 NA NA NA hsa-let-7b-5p STAT2 -1.62016148171663 1.56547487335694e-15 0.509864514303379 1.40678909724171e-05 MirTarget -0.120472182803361 3.03964706264741e-06 NA NA NA hsa-let-7d-5p STAT2 -0.618145137285851 6.06067642715858e-05 0.509864514303379 1.40678909724171e-05 MirTarget -0.1528271105592 1.39326427489514e-05 NA NA NA hsa-miR-24-3p STAT2 -0.0357874587555003 0.785865078836504 0.509864514303379 1.40678909724171e-05 MirTarget -0.161261626070144 0.000116257117501809 NA NA NA hsa-miR-335-5p STAT2 -0.466533891325811 0.0676987038122831 0.509864514303379 1.40678909724171e-05 miRNAWalker2_validate -0.132077013824439 2.03305813605633e-08 NA NA NA hsa-miR-106b-5p STAT3 1.47447672652218 1.32004094930462e-13 -0.388009307102648 0.000224860641368747 miRNATAP -0.109409419335066 3.62184558529254e-06 27325313 We also found that EMMPRIN could down-regulate miR-106a and miR-106b expression in breast cancer cells which led to activating STAT3 and enhancing HIF-1α expression breast cancer hsa-miR-17-5p STAT3 2.07078488653279 2.77403038572568e-19 -0.388009307102648 0.000224860641368747 TargetScan;miRNATAP -0.105584389232157 1.3114839292834e-07 NA NA NA hsa-miR-20a-5p STAT3 2.64649625616975 5.1469418982085e-27 -0.388009307102648 0.000224860641368747 miRNAWalker2_validate;miRNATAP -0.100732613891864 4.35743423210324e-08 NA NA NA hsa-miR-590-5p STAT3 2.07441240363458 4.95240551694843e-14 -0.388009307102648 0.000224860641368747 miRanda;miRNATAP -0.124157774543218 3.19384403462665e-09 27757042 We found that the AKT/ERK and STAT3 signaling pathways were activated by miR-590-5p overexpression gastric cancer hsa-miR-93-5p STAT3 1.50844106515467 1.83836866996875e-12 -0.388009307102648 0.000224860641368747 miRNAWalker2_validate;miRNATAP -0.137552388421614 2.76235773367141e-10 NA NA NA hsa-miR-125a-3p STAT4 -1.04954492275266 2.45974219476832e-06 0.0961884450057191 0.683361550310017 miRanda -0.185927041946743 0.000112433100972533 NA NA NA hsa-miR-200a-3p STAT4 3.14766878548496 1.32850889777422e-21 0.0961884450057191 0.683361550310017 MirTarget -0.126178484033207 8.31361865255989e-05 NA NA NA hsa-miR-320b STAT4 0.226640952564488 0.378818692487242 0.0961884450057191 0.683361550310017 MirTarget;PITA;miRanda -0.115023234627919 0.00643667817352199 NA NA NA hsa-miR-141-3p STAT5A 3.36993755486106 5.42939251147195e-32 -0.905104753560244 1.41317916283894e-08 MirTarget;TargetScan;miRNATAP -0.190377674442908 6.09934077828363e-16 25241899 Progesterone downregulation of miR 141 contributes to expansion of stem like breast cancer cells through maintenance of progesterone receptor and Stat5a; miR-141 directly targeted both PR and signal transducer and activator of transcription 5A Stat5a transcription factors important for MaSC expansion; These data support a mechanism by which P4-triggered loss of miR-141 facilitates breast cancer cell de-differentiation through deregulation of PR and Stat5a two transcription factors important for controlling mammary cell fate differentiation breast cancer hsa-miR-141-5p STAT5A 3.02575703771074 1.54385222591327e-32 -0.905104753560244 1.41317916283894e-08 MirTarget -0.202527795359664 2.35895271200081e-14 25241899 Progesterone downregulation of miR 141 contributes to expansion of stem like breast cancer cells through maintenance of progesterone receptor and Stat5a; miR-141 directly targeted both PR and signal transducer and activator of transcription 5A Stat5a transcription factors important for MaSC expansion; These data support a mechanism by which P4-triggered loss of miR-141 facilitates breast cancer cell de-differentiation through deregulation of PR and Stat5a two transcription factors important for controlling mammary cell fate differentiation breast cancer hsa-miR-200a-3p STAT5A 3.14766878548496 1.32850889777422e-21 -0.905104753560244 1.41317916283894e-08 MirTarget;miRNATAP -0.118718063376573 5.73889505633866e-08 NA NA NA hsa-miR-421 STAT5A 0.170525317701774 0.535277026680289 -0.905104753560244 1.41317916283894e-08 miRanda -0.127501722080265 1.37994750738141e-05 NA NA NA hsa-miR-21-3p STAT5B 2.54206008030157 1.11598785398763e-30 -0.663451908918001 4.74383359156865e-11 MirTarget -0.106584439373215 7.5044827818939e-08 NA NA NA hsa-miR-23a-3p STAT5B 0.111958289789488 0.393086414480463 -0.663451908918001 4.74383359156865e-11 MirTarget;miRNATAP -0.119797619427733 0.00106453944052763 NA NA NA hsa-miR-361-5p STAT6 0.21454431962475 0.0800957579368424 -0.420119585732164 0.000535927264583485 miRanda -0.150865221915038 0.00117667535932525 NA NA NA hsa-miR-590-3p STAT6 0.83851360565783 0.00129224433453587 -0.420119585732164 0.000535927264583485 miRanda -0.104608528719588 4.33717941879361e-05 NA NA NA hsa-miR-590-5p STAT6 2.07441240363458 4.95240551694843e-14 -0.420119585732164 0.000535927264583485 miRanda -0.122859354361777 4.43007690947911e-07 NA NA NA hsa-miR-29a-5p TSLP 1.89519956688438 1.03453349363915e-11 -2.5299543488034 1.75767380834244e-10 mirMAP -0.261301234490837 0.000828265487431527 NA NA NA hsa-miR-590-3p TSLP 0.83851360565783 0.00129224433453587 -2.5299543488034 1.75767380834244e-10 miRanda;mirMAP -0.244997006281775 0.00421059532141685 NA NA NA