miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-139-5p AAK1 -2.11299531796557 8.16407076415038e-28 0.62162910644816 6.70592413003848e-11 PITA -0.144522015156349 1.21538091542813e-10 NA NA NA hsa-miR-10b-5p ABAT 2.86931593037303 6.97409423207806e-23 -2.16281544019696 3.93403666966165e-18 mirMAP -0.160201428213243 9.05088632523481e-05 NA NA NA hsa-miR-183-5p ABAT 2.33444328833177 1.52188109365421e-10 -2.16281544019696 3.93403666966165e-18 MirTarget -0.267104765020534 3.51722235219066e-16 NA NA NA hsa-miR-183-5p ABCA8 2.33444328833177 1.52188109365421e-10 -2.95678182066224 1.90834103956612e-13 MirTarget -0.394453612448358 5.96012708879643e-14 NA NA NA hsa-miR-424-5p ABCB9 -2.62653257498508 2.38997974737991e-50 1.00955603859492 1.63896842371547e-09 mirMAP -0.110788990253611 0.00796099071353235 NA NA NA hsa-miR-139-5p ABCC5 -2.11299531796557 8.16407076415038e-28 1.23282495059029 1.29865153692267e-30 miRanda;mirMAP -0.254501274967874 5.53652125336645e-23 NA NA NA hsa-miR-3607-3p ABCC5 -2.15518588554493 1.03390728226728e-23 1.23282495059029 1.29865153692267e-30 MirTarget;miRNATAP -0.149609770488288 7.13932226011263e-10 NA NA NA hsa-miR-424-5p ABCC5 -2.62653257498508 2.38997974737991e-50 1.23282495059029 1.29865153692267e-30 MirTarget;miRNATAP -0.133944870108549 1.63537152696551e-06 NA NA NA hsa-miR-10b-3p ABHD2 2.77189254628215 2.26687582932628e-20 -1.20462139360653 3.09717296882448e-15 mirMAP -0.12934005722759 7.78689402710543e-07 NA NA NA hsa-miR-10b-5p ABHD2 2.86931593037303 6.97409423207806e-23 -1.20462139360653 3.09717296882448e-15 mirMAP -0.110361860730207 8.62842425205082e-06 NA NA NA hsa-miR-224-5p ABHD2 2.67175249172213 1.46995328399796e-18 -1.20462139360653 3.09717296882448e-15 mirMAP -0.124476641071974 2.0157541016819e-07 NA NA NA hsa-miR-139-5p ABI2 -2.11299531796557 8.16407076415038e-28 0.140168313926931 0.173394233347582 miRanda -0.153796193218561 8.50264359841145e-11 NA NA NA hsa-let-7g-3p ABL2 -1.14091000722297 8.32736018188759e-19 0.604144141236531 5.10108537709865e-11 mirMAP -0.115643474144471 0.000683123118252788 NA NA NA hsa-miR-125b-5p ABL2 -1.35767721102906 1.16564617395164e-18 0.604144141236531 5.10108537709865e-11 MirTarget -0.167501708345675 2.29590366599451e-09 NA NA NA hsa-miR-139-5p ABL2 -2.11299531796557 8.16407076415038e-28 0.604144141236531 5.10108537709865e-11 miRanda -0.123750936663783 1.37872139266035e-08 NA NA NA hsa-miR-192-3p ABL2 -0.6401165114007 0.000266272092403814 0.604144141236531 5.10108537709865e-11 MirTarget -0.132455576431082 2.38671466579862e-07 NA NA NA hsa-miR-26b-5p ABL2 -1.10804856399744 4.14176110314282e-22 0.604144141236531 5.10108537709865e-11 MirTarget;miRNATAP -0.115583643735275 0.00239652969744567 NA NA NA hsa-miR-29a-3p ABL2 -0.856762511178136 4.65330336378459e-12 0.604144141236531 5.10108537709865e-11 mirMAP -0.12594003813526 0.000478860732679419 NA NA NA hsa-miR-29b-3p ABL2 -0.348885528720517 0.0121441341291285 0.604144141236531 5.10108537709865e-11 mirMAP -0.105183496627116 0.00138768447102374 NA NA NA hsa-miR-30e-3p ABL2 -1.20845647373031 3.10263633528203e-25 0.604144141236531 5.10108537709865e-11 mirMAP -0.190960968389543 2.05411476692476e-07 NA NA NA hsa-miR-30e-5p ABL2 -0.627815042856657 3.02205690184908e-10 0.604144141236531 5.10108537709865e-11 mirMAP -0.182238354023163 5.40133886853721e-05 NA NA NA hsa-miR-378a-3p ABL2 -1.1920055906972 3.23538871733634e-10 0.604144141236531 5.10108537709865e-11 mirMAP -0.191717466619759 3.64699968112031e-17 NA NA NA hsa-miR-378c ABL2 -1.54028191929038 2.70131554214866e-15 0.604144141236531 5.10108537709865e-11 mirMAP -0.21202702057266 6.50527713843783e-23 NA NA NA hsa-miR-505-3p ABL2 -1.20027021591555 1.27927500175937e-13 0.604144141236531 5.10108537709865e-11 miRNATAP -0.183079437299495 8.55858797951429e-12 NA NA NA hsa-miR-576-5p ABL2 -0.377452008285847 0.00470735657343984 0.604144141236531 5.10108537709865e-11 mirMAP -0.12475441786958 0.00026374453873928 NA NA NA hsa-miR-139-5p ACACA -2.11299531796557 8.16407076415038e-28 0.777902042094557 1.56408455357082e-10 miRanda -0.212890299359479 6.92846959705388e-14 NA NA NA hsa-miR-224-5p ACAT1 2.67175249172213 1.46995328399796e-18 -1.61982651854581 1.24371695502075e-23 MirTarget -0.134553146134412 2.08767571822971e-07 NA NA NA hsa-miR-139-5p ACD -2.11299531796557 8.16407076415038e-28 0.567060492165262 1.18819652523605e-09 miRanda -0.184845031998396 7.81566270356752e-18 NA NA NA hsa-miR-139-5p ACLY -2.11299531796557 8.16407076415038e-28 1.02171988222232 3.44416828684327e-24 miRanda -0.229917876924863 5.9120635779436e-22 NA NA NA hsa-miR-144-3p ACSL4 -2.97536914478815 6.00546047309683e-28 2.07128895001209 1.06074462060898e-08 MirTarget;miRNATAP -0.331832016254304 5.18238730778078e-08 NA NA NA hsa-miR-424-5p ACSL4 -2.62653257498508 2.38997974737991e-50 2.07128895001209 1.06074462060898e-08 MirTarget;miRNATAP -0.215447988555811 0.0169839807315258 NA NA NA hsa-miR-139-3p ADAM11 -2.53151940925585 1.56777509736867e-36 1.25087795197574 5.34939899503878e-07 MirTarget -0.216900684354155 0.000104553465959243 NA NA NA hsa-miR-3607-3p ADAM11 -2.15518588554493 1.03390728226728e-23 1.25087795197574 5.34939899503878e-07 miRNATAP -0.24884779382427 3.66882181808351e-06 NA NA NA hsa-miR-139-5p ADAM12 -2.11299531796557 8.16407076415038e-28 0.932873928230232 0.0022018820638591 miRanda -0.370096155057971 2.0870545371508e-07 NA NA NA hsa-miR-3607-3p ADAM12 -2.15518588554493 1.03390728226728e-23 0.932873928230232 0.0022018820638591 mirMAP;miRNATAP -0.271596146194876 3.11070950125972e-05 NA NA NA hsa-miR-144-3p ADAM22 -2.97536914478815 6.00546047309683e-28 1.16776109376783 0.000384818007613429 mirMAP -0.208227286283695 0.000162205825372069 NA NA NA hsa-miR-3607-3p ADAM22 -2.15518588554493 1.03390728226728e-23 1.16776109376783 0.000384818007613429 mirMAP -0.302595673048835 1.76079074053488e-05 NA NA NA hsa-miR-183-5p ADAMTS13 2.33444328833177 1.52188109365421e-10 -3.24978566492456 1.87481661112528e-60 mirMAP -0.138064678862623 3.57567797255564e-06 NA NA NA hsa-miR-10b-3p ADAMTS2 2.77189254628215 2.26687582932628e-20 -2.30943429471583 3.31328280089205e-13 mirMAP -0.400602662685866 4.58478851857163e-14 24897960 The addition of miR-10b RERs to the Nottingham Prognostic Index NPI provided an improvement in discrimination power and risk reclassification abilities for the clinical outcomes at 36 months breast cancer hsa-miR-10b-5p ADAMTS2 2.86931593037303 6.97409423207806e-23 -2.30943429471583 3.31328280089205e-13 MirTarget -0.296016332616102 5.92190583740183e-09 24897960 The addition of miR-10b RERs to the Nottingham Prognostic Index NPI provided an improvement in discrimination power and risk reclassification abilities for the clinical outcomes at 36 months breast cancer hsa-miR-224-5p ADAMTS2 2.67175249172213 1.46995328399796e-18 -2.30943429471583 3.31328280089205e-13 mirMAP -0.204498245123724 4.05201147176566e-05 NA NA NA hsa-miR-139-5p ADAMTS6 -2.11299531796557 8.16407076415038e-28 0.701299206204912 0.00474632625270224 miRanda -0.28255491117131 1.18530577608489e-06 NA NA NA hsa-miR-139-5p ADAMTS9 -2.11299531796557 8.16407076415038e-28 0.803614851989758 4.10280431675718e-06 miRanda -0.211018271614109 2.81001104273089e-07 NA NA NA hsa-miR-10b-3p ADCY1 2.77189254628215 2.26687582932628e-20 -2.70370487380383 7.2704291027202e-13 mirMAP -0.233656690883932 0.000305046010886053 NA NA NA hsa-miR-10b-5p ADCY1 2.86931593037303 6.97409423207806e-23 -2.70370487380383 7.2704291027202e-13 mirMAP -0.131451556704975 0.0324412930997605 NA NA NA hsa-miR-224-5p ADCYAP1 2.67175249172213 1.46995328399796e-18 -1.13859452803686 0.000422708657680485 mirMAP -0.108748447017147 0.0292762580705047 NA NA NA hsa-miR-139-5p ADORA2B -2.11299531796557 8.16407076415038e-28 -0.0567240812410876 0.821235118326008 miRanda -0.278462142180668 1.97321384709714e-06 NA NA NA hsa-miR-10b-5p ADRA1B 2.86931593037303 6.97409423207806e-23 -2.33500633968218 2.2226391505243e-18 miRNAWalker2_validate -0.175590182462508 6.26148621686155e-05 NA NA NA hsa-miR-3607-3p AFAP1 -2.15518588554493 1.03390728226728e-23 0.333594871057281 0.0594854227669168 mirMAP -0.149797554354011 7.25965257218856e-05 NA NA NA hsa-miR-33b-5p AFF2 -2.28852395459234 2.69046626645242e-22 1.39588537883969 0.000457287577801629 mirMAP;miRNATAP -0.329982254216075 2.7053770741722e-05 NA NA NA hsa-miR-3607-3p AFF2 -2.15518588554493 1.03390728226728e-23 1.39588537883969 0.000457287577801629 mirMAP -0.291876546143781 0.000658768664349275 NA NA NA hsa-miR-3607-3p AFF3 -2.15518588554493 1.03390728226728e-23 -0.32341606139977 0.289744604640091 mirMAP;miRNATAP -0.172531874245634 0.00839515616063801 NA NA NA hsa-miR-424-5p AGAP3 -2.62653257498508 2.38997974737991e-50 0.258456449610529 0.00332053270890104 miRNATAP -0.100285775393445 2.55985323195819e-06 NA NA NA hsa-miR-3607-3p AGPAT4 -2.15518588554493 1.03390728226728e-23 0.868498368821504 6.97076886009297e-05 mirMAP -0.162218131331435 0.00056431526698357 NA NA NA hsa-miR-144-3p AGRN -2.97536914478815 6.00546047309683e-28 0.715007721538266 3.92826741843964e-07 miRNATAP -0.147354599858296 3.3336525735239e-10 NA NA NA hsa-miR-139-5p AHSA2 -2.11299531796557 8.16407076415038e-28 1.40797883181737 3.95534161646942e-23 miRanda -0.162693977657587 3.5599013666633e-06 NA NA NA hsa-miR-183-5p AKAP12 2.33444328833177 1.52188109365421e-10 -1.35597968849681 6.58582399222702e-07 miRNAWalker2_validate;miRTarBase -0.11063265768905 0.00211637381310644 NA NA NA hsa-miR-675-3p AKR1C1 -2.78074157259259 1.41541888062227e-14 -0.121013255853734 0.654126652200671 mirMAP -0.143420414443684 4.01637142202942e-05 NA NA NA hsa-miR-21-5p AKT2 1.51084295924322 1.54551622173259e-34 -0.343608685894869 1.25471482871759e-05 miRNAWalker2_validate -0.246625533117166 4.43585626011661e-19 NA NA NA hsa-miR-330-5p AKT2 0.442231058604099 0.0053308560843808 -0.343608685894869 1.25471482871759e-05 miRanda -0.10429759179516 1.49133299948889e-05 NA NA NA hsa-miR-342-3p AKT2 -0.319677314984262 0.0449813878317147 -0.343608685894869 1.25471482871759e-05 mirMAP -0.124944719707983 1.72780303356483e-07 NA NA NA hsa-miR-106b-5p AKT3 0.648901865047099 8.24870862047885e-09 -0.658799312069129 0.000471762262250455 miRNATAP -0.257549207275002 0.00147770551388523 NA NA NA hsa-miR-107 AKT3 0.241662461253461 0.0170788899505389 -0.658799312069129 0.000471762262250455 PITA;miRanda -0.603074134996255 1.95007791380395e-11 NA NA NA hsa-miR-122-5p AKT3 -1.23907441373955 4.42181244888642e-06 -0.658799312069129 0.000471762262250455 miRNAWalker2_validate;miRTarBase -0.282597613468804 3.13172096832783e-18 24244539 miR 122 regulates tumorigenesis in hepatocellular carcinoma by targeting AKT3; Here we identify AKT3 as a novel and direct target of miR-122; Restoration of miR-122 expression in HCC cell lines decreases AKT3 levels inhibits cell migration and proliferation and induces apoptosis; These anti-tumor phenotypes can be rescued by reconstitution of AKT3 expression indicating the essential role of AKT3 in miR-122 mediated HCC transformation; Our data strongly suggest that miR-122 is a tumor suppressor that targets AKT3 to regulate tumorigenesis in HCCs and a potential therapeutic candidate for liver cancer tumorigenesis;cell migration liver cancer hsa-miR-146b-5p AKT3 0.419719546795449 0.0457375823220155 -0.658799312069129 0.000471762262250455 miRNAWalker2_validate -0.159678144375669 0.000263366078999813 NA NA NA hsa-miR-15a-5p AKT3 0.349521211668244 0.000770735998804736 -0.658799312069129 0.000471762262250455 miRNAWalker2_validate;miRTarBase;miRNATAP -0.265425410812535 0.00291348888530609 NA NA NA hsa-miR-17-3p AKT3 0.410352776142368 0.00422200500748636 -0.658799312069129 0.000471762262250455 miRNATAP -0.350392140268267 3.46133659001702e-08 NA NA NA hsa-miR-17-5p AKT3 0.698861147045461 2.43854106455398e-05 -0.658799312069129 0.000471762262250455 TargetScan;miRNATAP -0.290786763807918 1.04942988053081e-07 NA NA NA hsa-miR-20a-5p AKT3 0.854326758727003 5.04256669663285e-07 -0.658799312069129 0.000471762262250455 miRNATAP -0.294574079686222 2.60181650003526e-08 NA NA NA hsa-miR-32-3p AKT3 0.219109440121582 0.207217051619543 -0.658799312069129 0.000471762262250455 mirMAP -0.225932925933496 3.62088303609835e-05 NA NA NA hsa-miR-33a-3p AKT3 -0.683025859637737 1.01106097756419e-05 -0.658799312069129 0.000471762262250455 mirMAP -0.229716914608906 0.000100074832030455 NA NA NA hsa-miR-362-3p AKT3 0.814007335895913 2.00108618836568e-09 -0.658799312069129 0.000471762262250455 miRanda -0.223301194831745 0.00083465748836002 NA NA NA hsa-miR-362-5p AKT3 0.717921690799312 1.68392734504524e-05 -0.658799312069129 0.000471762262250455 PITA;TargetScan;miRNATAP -0.147261080417749 0.00734435768679755 NA NA NA hsa-miR-374a-5p AKT3 0.016390363747302 0.869784217438621 -0.658799312069129 0.000471762262250455 mirMAP -0.277843537840681 0.00293899073092604 NA NA NA hsa-miR-421 AKT3 0.941856334694081 6.12167297054077e-08 -0.658799312069129 0.000471762262250455 miRanda;mirMAP -0.133809007743249 0.0109099775591746 NA NA NA hsa-miR-501-3p AKT3 0.999540908940094 2.77358485581974e-11 -0.658799312069129 0.000471762262250455 miRNATAP -0.119128898090902 0.0482272940757398 NA NA NA hsa-miR-502-3p AKT3 0.659598854007546 3.01316453996423e-08 -0.658799312069129 0.000471762262250455 miRNATAP -0.256952206617794 0.000795069967308112 NA NA NA hsa-miR-616-5p AKT3 0.150569904638223 0.402836556304524 -0.658799312069129 0.000471762262250455 mirMAP -0.200000357827185 9.73725948226915e-05 NA NA NA hsa-miR-93-5p AKT3 1.39518349670953 2.84167728726712e-25 -0.658799312069129 0.000471762262250455 miRNATAP -0.283992832133781 1.04884093066001e-05 NA NA NA hsa-miR-224-5p ALDH6A1 2.67175249172213 1.46995328399796e-18 -2.57441353609337 5.80735355109019e-24 mirMAP -0.241954282564803 2.90014012593043e-09 NA NA NA hsa-miR-139-5p ALG11 -2.11299531796557 8.16407076415038e-28 0.552553587673358 7.82580840010004e-05 miRanda -0.181587962412199 2.88670077603396e-08 NA NA NA hsa-miR-139-5p ALOX5 -2.11299531796557 8.16407076415038e-28 -0.637660997815708 0.020742548019736 miRanda -0.13573741265616 0.0374269160284868 NA NA NA hsa-miR-10b-3p AMOT 2.77189254628215 2.26687582932628e-20 -0.89778365109471 0.000787406411317435 mirMAP -0.137943510760411 0.00213706269739223 NA NA NA hsa-miR-139-5p AMPD3 -2.11299531796557 8.16407076415038e-28 0.132485092796905 0.47273753903343 miRanda -0.212026294612106 8.08360177246435e-07 NA NA NA hsa-miR-224-5p AMZ1 2.67175249172213 1.46995328399796e-18 -1.27523518848137 0.00014004218753246 mirMAP -0.106812880069567 0.0392487242521236 NA NA NA hsa-miR-139-5p ANAPC7 -2.11299531796557 8.16407076415038e-28 0.839259014209164 3.12717900375048e-28 miRanda -0.201479395472035 1.48359984931874e-29 NA NA NA hsa-miR-125a-5p ANGPT2 -0.91219969372382 1.38256246489548e-07 1.15268392731739 7.05586126458027e-10 miRanda -0.163576686828727 0.00200134342077289 NA NA NA hsa-miR-142-5p ANGPT2 -1.44575553250033 1.18797044680592e-13 1.15268392731739 7.05586126458027e-10 MirTarget -0.176235051817787 0.000132150168489542 NA NA NA hsa-miR-145-5p ANGPT2 -1.4795885711477 6.47308361543414e-16 1.15268392731739 7.05586126458027e-10 MirTarget;miRNATAP -0.196630651852303 5.50134414980236e-05 24384875;27570490 miR 145 functions as tumor suppressor and targets two oncogenes ANGPT2 and NEDD9 in renal cell carcinoma; We further validated those miR-145 targets two oncogenes ANGPT2 and NEDD9 in RCC;MiR 145 functions as a tumor suppressor via regulating angiopoietin 2 in pancreatic cancer cells; The direct action of miR-145 on Ang-2 was predicted by TargetScan and confirmed by luciferase report assay; The expression level of miR-145 was significantly lower and the expression levels of Ang-2 mRNA and protein was significantly higher in the more aggressive pancreatic cancer cells MiaPaCa-2 and Panc-1 when compared to that in BxPC3 cells; Overexpression of miR-145 in the BxPC3 MiaPaCa-2 and Panc-1 cells suppressed the cell invasion and colony formation ability and the expression level of Ang-2 protein in MiaPaCa-2 and Panc-1 cells was also suppressed after pre-miR-145 transfection; Intratumoral delivery of miR-145 inhibited the growth of pancreatic cancer xenografts and angiogenesis in vivo and also suppressed the expression level of angiopoietin-2 protein; MiR-145 functions as a tumor suppressor in pancreatic cancer cells by targeting Ang-2 for translation repression and thus suppresses pancreatic cancer cell invasion and growth which suggests that restoring of miR-145 may be a potential therapeutic target for pancreatic cancer ; kidney renal cell cancer;pancreatic cancer hsa-miR-335-3p ANGPT2 -0.275199247483111 0.106629165248783 1.15268392731739 7.05586126458027e-10 mirMAP -0.161794274727677 0.0030395747905161 NA NA NA hsa-miR-33a-3p ANGPT2 -0.683025859637737 1.01106097756419e-05 1.15268392731739 7.05586126458027e-10 mirMAP -0.150436088705081 0.0118915648597393 NA NA NA hsa-miR-3607-3p ANGPT2 -2.15518588554493 1.03390728226728e-23 1.15268392731739 7.05586126458027e-10 mirMAP -0.104579906447186 0.0106240889085937 NA NA NA hsa-miR-429 ANGPT2 -1.40262535827285 6.93982219171912e-05 1.15268392731739 7.05586126458027e-10 miRanda -0.100569047157387 0.00013697862777396 NA NA NA hsa-miR-542-3p ANGPT2 -1.31351015149842 3.64642423288576e-22 1.15268392731739 7.05586126458027e-10 MirTarget;miRanda;miRNATAP -0.356485535003704 3.05034551422058e-08 NA NA NA hsa-miR-744-3p ANGPT2 -0.866026958622846 2.43034431433797e-08 1.15268392731739 7.05586126458027e-10 MirTarget -0.153532830433855 0.00937263305214501 NA NA NA hsa-miR-424-5p ANKRD13B -2.62653257498508 2.38997974737991e-50 1.56995687270482 7.21236439677884e-16 miRNATAP -0.162538443390649 0.00096758953390888 NA NA NA hsa-miR-139-5p ANKRD13D -2.11299531796557 8.16407076415038e-28 0.793371386887663 1.12366210337644e-10 miRanda -0.263865794168272 9.93319584271754e-21 NA NA NA hsa-miR-139-5p ANKRD27 -2.11299531796557 8.16407076415038e-28 0.900670804616695 4.42329061698872e-15 miRanda -0.24358832116407 8.58574474440152e-20 NA NA NA hsa-miR-33b-5p ANKRD29 -2.28852395459234 2.69046626645242e-22 1.13442887011441 3.88269238474571e-05 MirTarget -0.113588249147455 0.0389064374838301 NA NA NA hsa-miR-424-5p ANKRD29 -2.62653257498508 2.38997974737991e-50 1.13442887011441 3.88269238474571e-05 MirTarget -0.275245634343233 4.71525284784583e-05 NA NA NA hsa-miR-199a-3p ANKRD52 -2.3279328685682 1.04468066198593e-17 1.45719998646575 1.747377108051e-36 PITA;miRNATAP -0.108833011429576 3.97550251967124e-07 NA NA NA hsa-miR-199b-3p ANKRD52 -2.33226605401203 9.51887435273314e-18 1.45719998646575 1.747377108051e-36 PITA;miRNATAP -0.108887532266439 3.84427109439024e-07 NA NA NA hsa-miR-3607-3p ANKRD52 -2.15518588554493 1.03390728226728e-23 1.45719998646575 1.747377108051e-36 miRNATAP -0.2201853622495 2.89149130090883e-17 NA NA NA hsa-miR-139-5p ANKS1B -2.11299531796557 8.16407076415038e-28 1.42896170044545 0.000117665176391669 miRanda -0.378448451422675 1.53786994366898e-05 NA NA NA hsa-miR-424-5p ANLN -2.62653257498508 2.38997974737991e-50 3.88656909930585 1.21152402703192e-46 miRNAWalker2_validate;miRTarBase -0.590044988957788 2.19191607693722e-16 NA NA NA hsa-miR-3607-3p ANO4 -2.15518588554493 1.03390728226728e-23 1.35799914292886 3.42007165442038e-06 MirTarget;miRNATAP -0.280087135207841 8.58355330555935e-06 NA NA NA hsa-miR-10b-3p ANTXR1 2.77189254628215 2.26687582932628e-20 -0.48250313082928 0.04008545083989 mirMAP -0.183424138161109 2.58803384318774e-06 NA NA NA hsa-miR-139-5p AP3B1 -2.11299531796557 8.16407076415038e-28 0.632267344636405 1.63239533876199e-17 miRanda -0.117257668478498 3.86919798588358e-11 NA NA NA hsa-miR-199a-3p AP3B1 -2.3279328685682 1.04468066198593e-17 0.632267344636405 1.63239533876199e-17 PITA -0.101077602181005 2.85213278192496e-15 NA NA NA hsa-miR-199b-3p AP3B1 -2.33226605401203 9.51887435273314e-18 0.632267344636405 1.63239533876199e-17 PITA -0.10104907095433 2.76822054551889e-15 NA NA NA hsa-miR-424-5p APLN -2.62653257498508 2.38997974737991e-50 3.68748588694903 4.52095574250086e-43 MirTarget;miRNATAP -0.752849377399642 2.73599408715958e-28 NA NA NA hsa-miR-10b-5p APLNR 2.86931593037303 6.97409423207806e-23 -0.977972128143673 8.97237243860362e-05 miRNAWalker2_validate -0.175027893573818 9.32215058998694e-06 NA NA NA hsa-miR-139-5p APOBEC3D -2.11299531796557 8.16407076415038e-28 -0.102569385124823 0.639884833097262 miRanda -0.162933854492622 0.00156110664414336 NA NA NA hsa-miR-424-5p ARFGAP1 -2.62653257498508 2.38997974737991e-50 0.643781870064428 1.44556855471158e-13 mirMAP -0.149041093652136 2.88113997856603e-12 NA NA NA hsa-miR-139-5p ARHGAP18 -2.11299531796557 8.16407076415038e-28 0.240688416645274 0.0619660757363508 miRanda -0.113144942444367 0.000182926605926033 NA NA NA hsa-miR-3607-3p ARHGEF3 -2.15518588554493 1.03390728226728e-23 0.514078801527087 0.00381491088892432 MirTarget;miRNATAP -0.122918450244349 0.00126616928205155 NA NA NA hsa-miR-139-5p ARID3B -2.11299531796557 8.16407076415038e-28 0.456196233773583 0.000205068052872381 miRanda -0.159071417075904 2.98257420709078e-08 NA NA NA hsa-miR-139-5p ARL6IP6 -2.11299531796557 8.16407076415038e-28 0.345420979924758 0.00325586813514637 miRanda -0.145947023772159 9.65477560160551e-08 NA NA NA hsa-miR-139-5p ARMC2 -2.11299531796557 8.16407076415038e-28 0.747204926608838 3.72153714938171e-08 MirTarget -0.108099351229906 0.000853301488757763 NA NA NA hsa-miR-10b-3p ARNT2 2.77189254628215 2.26687582932628e-20 -0.543861673387904 0.165711161724635 mirMAP -0.200199344416296 0.00226448915064957 NA NA NA hsa-miR-3607-3p ARNT2 -2.15518588554493 1.03390728226728e-23 -0.543861673387904 0.165711161724635 mirMAP -0.171311441273127 0.0420605689188499 NA NA NA hsa-miR-139-5p ARPC4 -2.11299531796557 8.16407076415038e-28 0.191366168105914 0.0119334787822769 miRanda -0.120858956348606 4.33683945138654e-12 NA NA NA hsa-miR-3607-3p ASAP1 -2.15518588554493 1.03390728226728e-23 0.602171250732936 1.27059865202179e-05 MirTarget;mirMAP;miRNATAP -0.103703787923431 0.000487972167488703 NA NA NA hsa-miR-33b-5p ATP10A -2.28852395459234 2.69046626645242e-22 0.423558174992768 0.129770428114507 mirMAP -0.150851952211687 0.0062610490878847 NA NA NA hsa-miR-3607-3p ATP10B -2.15518588554493 1.03390728226728e-23 -0.240054821493775 0.56639195970384 MirTarget -0.240008335124308 0.0074399329300629 NA NA NA hsa-miR-139-5p ATP1B1 -2.11299531796557 8.16407076415038e-28 0.435860215585354 0.00298454483006672 miRanda -0.122786761005471 0.000384108808519167 NA NA NA hsa-miR-144-3p ATP1B1 -2.97536914478815 6.00546047309683e-28 0.435860215585354 0.00298454483006672 miRNATAP -0.12509494728822 2.85690880835595e-07 NA NA NA hsa-miR-139-5p ATP1B3 -2.11299531796557 8.16407076415038e-28 0.87044678799045 1.02682748957634e-07 miRanda -0.266761356445407 2.7533987298203e-12 NA NA NA hsa-miR-139-3p ATP5G2 -2.53151940925585 1.56777509736867e-36 0.298597035583363 0.000926154613790281 miRNATAP -0.12952903445802 4.02744398291099e-11 NA NA NA hsa-miR-139-5p ATP5G2 -2.11299531796557 8.16407076415038e-28 0.298597035583363 0.000926154613790281 miRanda -0.129579117086842 5.45553774259599e-10 NA NA NA hsa-miR-139-5p ATP7A -2.11299531796557 8.16407076415038e-28 0.251321858484382 0.0188455783467549 MirTarget;PITA;miRanda -0.103506742025443 3.6082778281787e-05 NA NA NA hsa-miR-424-5p ATXN7L2 -2.62653257498508 2.38997974737991e-50 1.06992494046032 6.78987290211496e-20 MirTarget;miRNATAP -0.229628469166064 2.54394680636103e-15 NA NA NA hsa-miR-424-5p ATXN7L3 -2.62653257498508 2.38997974737991e-50 0.698895357070855 3.23244219063052e-16 MirTarget;miRNATAP -0.137313552796301 9.51540495919772e-11 NA NA NA hsa-miR-424-5p AXIN2 -2.62653257498508 2.38997974737991e-50 0.113841868770703 0.752977397700815 MirTarget;miRNATAP -0.191832991796132 0.0301808709524209 NA NA NA hsa-miR-139-5p B3GALNT2 -2.11299531796557 8.16407076415038e-28 0.858182539115791 7.80788493062689e-23 MirTarget;miRanda -0.139274419070377 4.94415796767974e-11 NA NA NA hsa-miR-3607-3p B3GNT5 -2.15518588554493 1.03390728226728e-23 0.793070163988416 0.000903109981778052 MirTarget;miRNATAP -0.126894672061839 0.0137701736340365 NA NA NA hsa-miR-10b-5p B3GNT7 2.86931593037303 6.97409423207806e-23 -1.25477942271372 3.58589583052719e-07 mirMAP -0.11639276578779 0.00320629067817967 NA NA NA hsa-miR-10b-5p BACH2 2.86931593037303 6.97409423207806e-23 -1.98817818659277 2.20288210770245e-15 MirTarget;miRNATAP -0.172940068352622 2.27051084797799e-05 NA NA NA hsa-miR-139-5p BAGE -2.11299531796557 8.16407076415038e-28 1.24926414369061 0.000880665358020787 miRanda -0.414688048045201 2.60066264047583e-06 NA NA NA hsa-miR-139-5p BAZ2A -2.11299531796557 8.16407076415038e-28 0.461073155925693 4.28128289777929e-08 miRanda;miRNATAP -0.154526668196138 1.7410454662473e-15 NA NA NA hsa-miR-139-5p BBC3 -2.11299531796557 8.16407076415038e-28 0.804667864310401 1.64815736901645e-10 miRNATAP -0.234947411363537 1.07629281857681e-15 NA NA NA hsa-miR-144-3p BBC3 -2.97536914478815 6.00546047309683e-28 0.804667864310401 1.64815736901645e-10 miRNATAP -0.108503369572842 3.4984805094146e-07 NA NA NA hsa-miR-139-5p BBS7 -2.11299531796557 8.16407076415038e-28 0.266690014901358 0.0901347389297157 miRanda -0.105684054776202 0.00433666255343418 NA NA NA hsa-miR-3607-3p BCL11A -2.15518588554493 1.03390728226728e-23 -0.11732578696554 0.708897593291357 mirMAP;miRNATAP -0.250663458081254 0.000183821662480883 NA NA NA hsa-miR-330-5p BCL2L1 0.442231058604099 0.0053308560843808 0.0225608953357561 0.827445946886033 PITA;miRanda;miRNATAP -0.154730615864034 7.70545597695822e-07 NA NA NA hsa-miR-342-3p BCL2L1 -0.319677314984262 0.0449813878317147 0.0225608953357561 0.827445946886033 PITA;miRanda;miRNATAP -0.123843624743073 7.98408137042515e-05 NA NA NA hsa-miR-342-5p BCL2L1 -0.780720763816797 5.21703298730986e-07 0.0225608953357561 0.827445946886033 miRNATAP -0.106591893041378 0.000835493298714261 NA NA NA hsa-miR-484 BCL2L1 0.0857240033709656 0.453982056282229 0.0225608953357561 0.827445946886033 miRNAWalker2_validate -0.214137045460272 1.02827848229123e-06 NA NA NA hsa-miR-183-5p BCL6 2.33444328833177 1.52188109365421e-10 -0.381728718096561 0.00304721869179574 miRNATAP -0.10362647905195 3.57423166242432e-10 NA NA NA hsa-miR-144-3p BCL9 -2.97536914478815 6.00546047309683e-28 1.17619476675548 1.43287619580645e-16 miRNATAP -0.207003610164137 3.1482712025425e-18 NA NA NA hsa-miR-139-5p BCORL1 -2.11299531796557 8.16407076415038e-28 0.512301558321965 0.000319198853421924 miRanda -0.191230743869179 8.43546750088891e-09 NA NA NA hsa-miR-103a-3p BDNF 0.765568928457606 3.05497476509383e-12 0.0509404608382562 0.831886089502745 MirTarget;miRNATAP -0.212283092323498 0.0423780555066314 NA NA NA hsa-miR-107 BDNF 0.241662461253461 0.0170788899505389 0.0509404608382562 0.831886089502745 MirTarget;PITA;miRanda;miRNATAP -0.548625326436466 1.91129941815694e-06 27498977 MicroRNA 107 inhibits tumor growth and metastasis by targeting the BDNF mediated PI3K/AKT pathway in human non small lung cancer; In addition BDNF expression was upregulated and inversely correlated with miR-107 in NSCLC tissues; Enforced overexpression of BDNF effectively reversed the tumor suppressive functions of miR-107 on NSCLC proliferation migration and invasion; miR-107 overexpression or downregulation of BDNF was able to inhibit activation of PI3K/AKT signaling pathway; Taken together our findings present the first evidence that miR-107 could suppress NSCLC metastasis by targeting BDNF and indirectly regulating PI3K/AKT signaling pathway which might lead to a potential therapeutic strategy focusing on miR-107 and BDNF for human NSCLC metastasis lung cancer hsa-miR-148a-5p BDNF -0.767626696027761 1.08359477494797e-06 0.0509404608382562 0.831886089502745 mirMAP -0.25723398567524 0.00044233258998089 NA NA NA hsa-miR-192-3p BDNF -0.6401165114007 0.000266272092403814 0.0509404608382562 0.831886089502745 MirTarget;miRNATAP -0.316265894039516 1.40962674503077e-06 NA NA NA hsa-miR-30d-5p BDNF 0.718283816348023 2.47422074061352e-08 0.0509404608382562 0.831886089502745 miRNATAP -0.295547331188199 0.000945690035537912 NA NA NA hsa-miR-33a-3p BDNF -0.683025859637737 1.01106097756419e-05 0.0509404608382562 0.831886089502745 mirMAP -0.15196333567788 0.0432393319217154 NA NA NA hsa-miR-589-5p BDNF 1.18593770505086 1.01781241960531e-22 0.0509404608382562 0.831886089502745 miRNATAP -0.237064825478246 0.0099909566497615 NA NA NA hsa-miR-144-3p BEND3 -2.97536914478815 6.00546047309683e-28 1.01774373383669 5.6745626823253e-12 miRNATAP -0.150731759598901 1.53402013137312e-09 NA NA NA hsa-miR-3607-3p BEND3 -2.15518588554493 1.03390728226728e-23 1.01774373383669 5.6745626823253e-12 mirMAP;miRNATAP -0.211313775658333 2.98900434271644e-11 NA NA NA hsa-miR-139-5p BFSP1 -2.11299531796557 8.16407076415038e-28 1.35950359514717 5.25906110985343e-15 miRanda -0.358388842246467 1.22500789329434e-18 NA NA NA hsa-miR-1269a BHLHE22 3.57543539205634 4.25369619949175e-08 -1.8780713907135 1.9887576917688e-08 MirTarget -0.180669967841729 1.71932278784066e-12 NA NA NA hsa-miR-139-5p BICD1 -2.11299531796557 8.16407076415038e-28 0.798278862498021 0.000395688075323181 miRanda -0.268287668097382 3.81667068388512e-07 NA NA NA hsa-miR-1269a BMPER 3.57543539205634 4.25369619949175e-08 -6.22874722091532 2.3884684161097e-65 MirTarget -0.197268142258934 1.34348958515761e-09 NA NA NA hsa-miR-33b-5p BRIP1 -2.28852395459234 2.69046626645242e-22 1.05558710574343 4.98525951061219e-05 MirTarget -0.183643246212897 0.000375640258322803 NA NA NA hsa-miR-424-5p BRPF3 -2.62653257498508 2.38997974737991e-50 0.347912163638623 0.00299376429932645 miRNATAP -0.124759543582671 1.20579412118318e-05 NA NA NA hsa-miR-33b-5p BSN -2.28852395459234 2.69046626645242e-22 0.943588815475765 2.35563209281755e-05 mirMAP -0.109030097782094 0.014247200256453 NA NA NA hsa-miR-3607-3p BSN -2.15518588554493 1.03390728226728e-23 0.943588815475765 2.35563209281755e-05 miRNATAP -0.114370631994419 0.0179362611418751 NA NA NA hsa-miR-139-5p BTBD3 -2.11299531796557 8.16407076415038e-28 0.299640501202244 0.00861061458292312 PITA;miRanda;miRNATAP -0.110630805087362 3.50507627481586e-05 NA NA NA hsa-miR-139-5p BTG3 -2.11299531796557 8.16407076415038e-28 0.623634374148549 2.28093634466613e-08 MirTarget;PITA;miRanda;miRNATAP -0.152653079783303 6.23712286381263e-09 NA NA NA hsa-miR-139-5p BUB1 -2.11299531796557 8.16407076415038e-28 4.04762666744344 9.60341711300894e-48 miRanda -0.981222586322315 6.07995380621313e-51 NA NA NA hsa-miR-139-5p BUB3 -2.11299531796557 8.16407076415038e-28 0.484122281215701 1.04333829038208e-13 miRanda -0.120530889452753 2.21957104706434e-15 NA NA NA hsa-miR-424-5p C11orf68 -2.62653257498508 2.38997974737991e-50 0.361076997403845 4.57133605719156e-06 miRNATAP -0.112527947743255 3.53973661802804e-09 NA NA NA hsa-miR-3607-3p C16orf74 -2.15518588554493 1.03390728226728e-23 0.468354591583293 0.0483467995563639 miRNATAP -0.145276402820699 0.00428866945436475 NA NA NA hsa-miR-3607-3p C18orf54 -2.15518588554493 1.03390728226728e-23 1.16077244077658 2.77953874933918e-11 mirMAP -0.203588275322015 7.18213893689248e-08 NA NA NA hsa-miR-424-5p C6orf106 -2.62653257498508 2.38997974737991e-50 0.17028043460772 0.0607652379703991 mirMAP -0.124032627373509 1.28117181207664e-08 NA NA NA hsa-miR-144-3p C6orf223 -2.97536914478815 6.00546047309683e-28 0.669280204465648 0.189250898670159 mirMAP -0.221326194562807 0.0095677540247239 NA NA NA hsa-miR-199a-3p C9orf40 -2.3279328685682 1.04468066198593e-17 0.597133001230743 1.19639278411742e-06 miRNATAP -0.129822029656752 6.05518061094651e-10 NA NA NA hsa-miR-199b-3p C9orf40 -2.33226605401203 9.51887435273314e-18 0.597133001230743 1.19639278411742e-06 miRNATAP -0.129804228301146 5.91189738419023e-10 NA NA NA hsa-miR-139-5p CA12 -2.11299531796557 8.16407076415038e-28 2.34009290257016 5.88059078525048e-07 miRanda -0.656485547846461 2.47106118304153e-09 NA NA NA hsa-miR-424-5p CABLES2 -2.62653257498508 2.38997974737991e-50 0.815780245768877 1.35421612402299e-10 MirTarget -0.182542870396736 5.08713161059192e-09 NA NA NA hsa-miR-139-5p CABYR -2.11299531796557 8.16407076415038e-28 2.4653172094018 3.56189744690791e-10 miRanda -0.514408758881954 3.68091222928769e-08 NA NA NA hsa-miR-33b-5p CACNA1C -2.28852395459234 2.69046626645242e-22 0.946440250430891 1.06436399202531e-05 MirTarget -0.179942561302315 2.37316566999313e-05 NA NA NA hsa-miR-139-5p CACNA1D -2.11299531796557 8.16407076415038e-28 0.0773051512884277 0.775671886109236 miRanda -0.229233752743874 0.00031572268935691 NA NA NA hsa-miR-144-3p CACNA1D -2.97536914478815 6.00546047309683e-28 0.0773051512884277 0.775671886109236 miRNATAP -0.136516465684352 0.00259740702432529 NA NA NA hsa-miR-424-5p CACNA1E -2.62653257498508 2.38997974737991e-50 1.61336046300478 3.88892981462269e-05 MirTarget -0.274692842643168 0.00450882167019575 NA NA NA hsa-miR-675-3p CACNA1E -2.78074157259259 1.41541888062227e-14 1.61336046300478 3.88892981462269e-05 mirMAP -0.115296803266607 0.0254404783289046 NA NA NA hsa-miR-139-5p CACNB4 -2.11299531796557 8.16407076415038e-28 1.93077881386314 4.3815389499992e-11 miRanda -0.242383497576797 0.000593181239775728 NA NA NA hsa-miR-144-3p CACNB4 -2.97536914478815 6.00546047309683e-28 1.93077881386314 4.3815389499992e-11 mirMAP -0.142809280455242 0.00448954130966617 NA NA NA hsa-miR-424-5p CACNB4 -2.62653257498508 2.38997974737991e-50 1.93077881386314 4.3815389499992e-11 miRNATAP -0.407184370467454 1.82523985428203e-08 NA NA NA hsa-miR-424-5p CADM1 -2.62653257498508 2.38997974737991e-50 -0.0259171422650883 0.886286112596045 miRNATAP -0.117931205622277 0.00767419172218007 NA NA NA hsa-miR-186-5p CALM1 -0.060103391373687 0.535288717081205 -0.578755932707853 1.61360998273395e-14 mirMAP -0.118942041026033 0.00255928363495106 NA NA NA hsa-miR-423-5p CALM1 0.698807775906485 1.02195196334612e-11 -0.578755932707853 1.61360998273395e-14 miRNATAP -0.218205096562437 8.21960188777568e-10 NA NA NA hsa-miR-27a-3p CALM3 -0.370807380415112 0.00875721956202713 0.208010932671678 0.0152703300792942 miRNATAP -0.103576968945132 0.000430930143154237 NA NA NA hsa-miR-27b-3p CALM3 -0.823491817819754 9.20935302746823e-14 0.208010932671678 0.0152703300792942 miRNAWalker2_validate;miRNATAP -0.106848099385636 0.00371755816496827 NA NA NA hsa-miR-29a-3p CALM3 -0.856762511178136 4.65330336378459e-12 0.208010932671678 0.0152703300792942 miRNATAP -0.106118651188382 0.001253685265849 NA NA NA hsa-miR-106a-5p CALML4 -0.464229535269236 0.009724944358047 0.0123352430389914 0.913187337479894 mirMAP -0.107885724713258 0.000398338923535089 NA NA NA hsa-miR-148b-5p CALML4 0.295777213389605 0.0255749859535438 0.0123352430389914 0.913187337479894 mirMAP -0.112110302032188 0.00713649765468876 NA NA NA hsa-miR-330-3p CALML4 -0.332364259424489 0.0316051913061459 0.0123352430389914 0.913187337479894 miRNATAP -0.116008578287933 0.00140843991919811 NA NA NA hsa-miR-500a-5p CALML4 0.797906382969156 9.15958171084226e-08 0.0123352430389914 0.913187337479894 mirMAP -0.133706314489441 0.000221055551269683 NA NA NA hsa-miR-7-1-3p CALML4 -0.569105143287799 1.85297665041424e-05 0.0123352430389914 0.913187337479894 mirMAP -0.120054903428042 0.00350044703658415 NA NA NA hsa-miR-10b-3p CAMK2B 2.77189254628215 2.26687582932628e-20 -3.79443915567367 4.19182064533683e-17 mirMAP -0.454957383759527 4.10184640844674e-09 NA NA NA hsa-miR-10b-5p CAMK2B 2.86931593037303 6.97409423207806e-23 -3.79443915567367 4.19182064533683e-17 miRNATAP -0.417096014841303 1.21569971542912e-08 NA NA NA hsa-miR-139-5p CAP2 -2.11299531796557 8.16407076415038e-28 2.07199486258754 2.16096186415872e-27 miRanda -0.203377603844363 2.12974771954628e-05 NA NA NA hsa-miR-139-5p CAPG -2.11299531796557 8.16407076415038e-28 1.1938845094456 1.58709718261221e-06 miRanda -0.499323362532113 1.84933740870131e-18 NA NA NA hsa-miR-424-5p CASKIN1 -2.62653257498508 2.38997974737991e-50 1.73450894991447 2.58018983860941e-08 miRNATAP -0.281551150777861 0.000266243386589989 NA NA NA hsa-miR-3607-3p CASP2 -2.15518588554493 1.03390728226728e-23 0.747584551486522 3.40542658570164e-14 mirMAP -0.158329257651367 7.05343879207709e-14 NA NA NA hsa-miR-139-5p CBFA2T2 -2.11299531796557 8.16407076415038e-28 1.20918131407154 1.46538376039906e-30 miRanda -0.25919054039271 7.54600236987952e-25 NA NA NA hsa-miR-144-3p CBFA2T2 -2.97536914478815 6.00546047309683e-28 1.20918131407154 1.46538376039906e-30 miRNATAP -0.159638398675541 1.7310969702606e-18 NA NA NA hsa-miR-139-5p CBX1 -2.11299531796557 8.16407076415038e-28 0.785716543008194 2.64595285870767e-18 MirTarget;PITA;miRanda -0.217704708170321 1.21394728091314e-25 NA NA NA hsa-miR-3607-3p CBX1 -2.15518588554493 1.03390728226728e-23 0.785716543008194 2.64595285870767e-18 MirTarget;miRNATAP -0.113592336496612 9.28495924057422e-09 NA NA NA hsa-miR-139-5p CBX3 -2.11299531796557 8.16407076415038e-28 0.524741548804984 1.00573650688867e-13 miRanda -0.17412407941427 1.04282925355637e-27 NA NA NA hsa-miR-139-5p CBX4 -2.11299531796557 8.16407076415038e-28 0.715798123604446 5.62055214425908e-11 miRanda -0.184581652608922 5.80121509805901e-13 NA NA NA hsa-miR-424-5p CBX4 -2.62653257498508 2.38997974737991e-50 0.715798123604446 5.62055214425908e-11 MirTarget;miRNATAP -0.1341885337034 6.75834361443722e-07 NA NA NA hsa-miR-3607-3p CBX6 -2.15518588554493 1.03390728226728e-23 -0.135925898836227 0.562356772831778 mirMAP -0.129907113749732 0.00972196675416719 NA NA NA hsa-miR-139-5p CCDC120 -2.11299531796557 8.16407076415038e-28 0.191395246466414 0.0626166577233953 miRanda -0.111516141724117 3.27020767673466e-06 NA NA NA hsa-miR-224-5p CCDC141 2.67175249172213 1.46995328399796e-18 -1.9064004464876 8.12592141838297e-11 MirTarget;mirMAP -0.103770645341047 0.0244253955383037 NA NA NA hsa-miR-139-5p CCDC30 -2.11299531796557 8.16407076415038e-28 0.274398283423032 0.0552721945714668 miRanda -0.104891194644162 0.00184213814932822 NA NA NA hsa-miR-199a-3p CCDC85C -2.3279328685682 1.04468066198593e-17 0.715583791803459 8.12293475957308e-09 MirTarget -0.113736928526141 1.10031873168676e-07 NA NA NA hsa-miR-199b-3p CCDC85C -2.33226605401203 9.51887435273314e-18 0.715583791803459 8.12293475957308e-09 MirTarget -0.113665517114027 1.0973019293746e-07 NA NA NA hsa-miR-424-5p CCDC85C -2.62653257498508 2.38997974737991e-50 0.715583791803459 8.12293475957308e-09 MirTarget -0.220425289543201 2.06280048153113e-13 NA NA NA hsa-miR-199a-3p CCDC88A -2.3279328685682 1.04468066198593e-17 0.586443666153583 1.17901243123154e-05 miRNATAP -0.113032545123368 8.64939120245296e-07 NA NA NA hsa-miR-199b-3p CCDC88A -2.33226605401203 9.51887435273314e-18 0.586443666153583 1.17901243123154e-05 miRNATAP -0.113148088897415 8.2676450470872e-07 NA NA NA hsa-miR-1269a CCL11 3.57543539205634 4.25369619949175e-08 -0.00086865799748459 0.99797170176235 MirTarget -0.102958888593 8.4748308731784e-05 NA NA NA hsa-miR-139-5p CCL20 -2.11299531796557 8.16407076415038e-28 1.78532685893413 6.54381823836718e-05 miRanda -0.77591055881833 5.67474403315445e-14 NA NA NA hsa-miR-139-5p CCNB1 -2.11299531796557 8.16407076415038e-28 3.15540953438863 5.73583669464518e-46 miRanda -0.800903870286373 3.33153076219979e-55 NA NA NA hsa-miR-3607-3p CCND2 -2.15518588554493 1.03390728226728e-23 0.356451160382274 0.0365641518216489 mirMAP -0.12362922199284 0.000700039964538526 NA NA NA hsa-miR-424-5p CCNE1 -2.62653257498508 2.38997974737991e-50 3.04640353472202 4.5986250804531e-28 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.365785229181321 3.5890870773903e-07 NA NA NA hsa-miR-139-5p CCNF -2.11299531796557 8.16407076415038e-28 2.17480980282222 4.71512834823536e-34 miRanda -0.576264627513631 1.09160580250179e-44 NA NA NA hsa-miR-424-5p CCNF -2.62653257498508 2.38997974737991e-50 2.17480980282222 4.71512834823536e-34 miRNAWalker2_validate;miRTarBase -0.3444709684845 8.89242632713063e-14 NA NA NA hsa-miR-139-5p CCNG2 -2.11299531796557 8.16407076415038e-28 0.198342536240394 0.0998646636491728 miRanda -0.116371718069027 3.6666214573436e-05 NA NA NA hsa-miR-3607-3p CCNI2 -2.15518588554493 1.03390728226728e-23 0.987990813889281 0.000261133291504858 MirTarget -0.203960710949244 0.000458966621266991 NA NA NA hsa-miR-139-5p CCT2 -2.11299531796557 8.16407076415038e-28 0.423084248752609 2.09405053842187e-08 miRanda -0.146632927555955 2.61634326526154e-17 NA NA NA hsa-miR-139-5p CCT5 -2.11299531796557 8.16407076415038e-28 0.645819223310014 4.22502070292735e-13 miRanda -0.211285909045434 2.40088655567591e-25 NA NA NA hsa-miR-139-5p CD24 -2.11299531796557 8.16407076415038e-28 0.742934316348121 0.0796924285756589 miRanda -0.721537002424399 1.14532938114115e-13 NA NA NA hsa-miR-183-5p CDC14B 2.33444328833177 1.52188109365421e-10 -1.18862488716786 6.19212759828214e-11 MirTarget -0.209168889921202 2.23918514009581e-19 NA NA NA hsa-miR-424-5p CDC25A -2.62653257498508 2.38997974737991e-50 1.92057841155944 2.96621670231863e-18 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.288771172993147 2.08206643580705e-07 NA NA NA hsa-miR-3607-3p CDC6 -2.15518588554493 1.03390728226728e-23 3.43409755895777 3.54117234711163e-45 mirMAP -0.421624410789328 1.12661397039956e-13 NA NA NA hsa-miR-3607-3p CDC7 -2.15518588554493 1.03390728226728e-23 2.01751950910415 4.47781393592943e-28 miRNATAP -0.281769617963819 7.78721407023138e-12 NA NA NA hsa-miR-139-5p CDCA7 -2.11299531796557 8.16407076415038e-28 2.57202359254754 6.79638114277778e-12 miRanda -0.759431610569321 2.8966485181344e-18 NA NA NA hsa-miR-139-5p CDCA7L -2.11299531796557 8.16407076415038e-28 0.484426770962648 0.01421551674655 miRanda -0.338517532366332 8.1652198478069e-14 NA NA NA hsa-miR-3607-3p CDCA7L -2.15518588554493 1.03390728226728e-23 0.484426770962648 0.01421551674655 MirTarget -0.115203885084532 0.0066195317576375 NA NA NA hsa-miR-139-5p CDCA8 -2.11299531796557 8.16407076415038e-28 3.14666984499479 3.07849548547044e-44 miRanda -0.790331340346671 1.41452018848051e-51 NA NA NA hsa-miR-139-5p CDH10 -2.11299531796557 8.16407076415038e-28 0.398138023469805 0.198412843512137 miRanda -0.436054470105072 1.16969367726728e-09 NA NA NA hsa-miR-3607-3p CDH10 -2.15518588554493 1.03390728226728e-23 0.398138023469805 0.198412843512137 MirTarget -0.261170293745747 7.60646251107237e-05 NA NA NA hsa-miR-139-5p CDH12 -2.11299531796557 8.16407076415038e-28 1.1182160226334 0.00141810830782612 miRanda -0.310519593728598 0.000172437593182026 NA NA NA hsa-miR-3607-3p CDH13 -2.15518588554493 1.03390728226728e-23 2.78568708356452 4.86055423461083e-60 miRNATAP -0.271132375820179 6.6785983519434e-11 NA NA NA hsa-miR-675-3p CDH13 -2.78074157259259 1.41541888062227e-14 2.78568708356452 4.86055423461083e-60 MirTarget -0.201559146518382 5.6292950865675e-16 NA NA NA hsa-miR-3607-3p CDH17 -2.15518588554493 1.03390728226728e-23 0.242846419960074 0.552704517509546 mirMAP -0.200737695632693 0.0220989230789644 NA NA NA hsa-miR-144-3p CDH6 -2.97536914478815 6.00546047309683e-28 -0.011269183333376 0.966488319003756 MirTarget -0.157641162895434 0.000424112339995811 NA NA NA hsa-miR-139-5p CDK1 -2.11299531796557 8.16407076415038e-28 3.60092865588574 2.53758251358007e-48 miRanda -0.838938956041355 1.17302084660509e-46 NA NA NA hsa-miR-139-5p CDK19 -2.11299531796557 8.16407076415038e-28 0.118030592068031 0.294061978811636 miRanda -0.139535351550119 8.94942880657542e-08 NA NA NA hsa-miR-199a-3p CDK5R1 -2.3279328685682 1.04468066198593e-17 1.08475307136185 2.13782053288791e-11 MirTarget;miRNATAP -0.104866408958392 0.000225105750630189 NA NA NA hsa-miR-199b-3p CDK5R1 -2.33226605401203 9.51887435273314e-18 1.08475307136185 2.13782053288791e-11 MirTarget;miRNATAP -0.105039396114083 0.000217369703782694 NA NA NA hsa-miR-424-5p CDK5R1 -2.62653257498508 2.38997974737991e-50 1.08475307136185 2.13782053288791e-11 MirTarget;miRNATAP -0.18898737195461 2.63370528036635e-06 NA NA NA hsa-miR-139-5p CDK7 -2.11299531796557 8.16407076415038e-28 0.491707717966495 7.16261478943003e-09 miRanda -0.14310504808171 4.57209013484235e-13 NA NA NA hsa-miR-144-3p CDKN2B -2.97536914478815 6.00546047309683e-28 1.37191742600332 3.8601745589837e-15 MirTarget -0.165363817374004 2.99908004062454e-08 NA NA NA hsa-miR-451a CDKN2B -2.1025161666445 6.82555767537341e-17 1.37191742600332 3.8601745589837e-15 MirTarget -0.162386705840671 1.05027558906518e-06 NA NA NA hsa-miR-139-5p CDRT1 -2.11299531796557 8.16407076415038e-28 1.63595015467407 4.5809516315446e-06 miRanda -0.290165902278094 0.000628624264914981 NA NA NA hsa-miR-139-5p CDYL -2.11299531796557 8.16407076415038e-28 0.406635443252195 1.20554482771922e-07 miRanda -0.105393117715583 4.68836621133533e-09 NA NA NA hsa-miR-3607-3p CELSR3 -2.15518588554493 1.03390728226728e-23 3.20386657067565 1.42274406912876e-34 MirTarget;miRNATAP -0.320607927498854 1.03452148600783e-07 NA NA NA hsa-miR-139-5p CENPF -2.11299531796557 8.16407076415038e-28 3.79236503476937 1.25674067170883e-49 miRanda -0.869576558035126 4.91439432167134e-46 NA NA NA hsa-miR-3607-3p CENPF -2.15518588554493 1.03390728226728e-23 3.79236503476937 1.25674067170883e-49 MirTarget -0.503759878800555 3.82210187086765e-17 NA NA NA hsa-miR-139-5p CENPJ -2.11299531796557 8.16407076415038e-28 1.26209084741411 2.53379592730583e-21 miRanda -0.3077649342811 8.03116488195722e-23 NA NA NA hsa-miR-144-3p CENPK -2.97536914478815 6.00546047309683e-28 2.91476240486479 2.54766199959213e-30 MirTarget -0.288162209284575 1.61421950095741e-10 NA NA NA hsa-miR-33b-5p CENPP -2.28852395459234 2.69046626645242e-22 1.58562892488644 4.26649488498792e-22 mirMAP -0.11217360656706 0.000990627767391564 NA NA NA hsa-miR-3607-3p CENPP -2.15518588554493 1.03390728226728e-23 1.58562892488644 4.26649488498792e-22 mirMAP -0.193318598297503 1.29578809781386e-07 NA NA NA hsa-miR-144-3p CENPQ -2.97536914478815 6.00546047309683e-28 1.0297870574531 7.53757997152427e-14 MirTarget -0.137483597062781 4.16288271723095e-09 NA NA NA hsa-miR-139-5p CENPW -2.11299531796557 8.16407076415038e-28 2.39005948255153 7.33753229215542e-34 miRanda -0.570338214903541 1.18821889472547e-34 NA NA NA hsa-miR-139-5p CEP290 -2.11299531796557 8.16407076415038e-28 1.07386234562723 6.55032111996192e-15 miRanda -0.160707713737178 1.34596290710154e-06 NA NA NA hsa-miR-424-5p CEP350 -2.62653257498508 2.38997974737991e-50 0.488306436373169 6.10029026629057e-08 miRNATAP -0.102938756340722 3.27887482475359e-06 NA NA NA hsa-miR-424-5p CEP55 -2.62653257498508 2.38997974737991e-50 2.874986535696 2.48808404875451e-31 MirTarget -0.336813075336938 1.74457624779576e-07 NA NA NA hsa-miR-199a-3p CHAD -2.3279328685682 1.04468066198593e-17 -0.971936204452971 0.000334764618282157 MirTarget;miRNATAP -0.173935024249055 0.000195324497109954 NA NA NA hsa-miR-199b-3p CHAD -2.33226605401203 9.51887435273314e-18 -0.971936204452971 0.000334764618282157 MirTarget -0.173511442303337 0.000200423270036301 NA NA NA hsa-miR-139-5p CHD7 -2.11299531796557 8.16407076415038e-28 0.374421521974899 0.00251042980327692 PITA;miRanda;miRNATAP -0.101872378429237 0.000480866668430879 NA NA NA hsa-miR-139-5p CHEK1 -2.11299531796557 8.16407076415038e-28 1.37723795528964 1.0573870902276e-18 miRanda -0.413297733218518 4.65960798548544e-31 NA NA NA hsa-miR-424-5p CHEK1 -2.62653257498508 2.38997974737991e-50 1.37723795528964 1.0573870902276e-18 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.283677722756659 2.52006692893939e-13 22469983 Suppressed miR 424 expression via upregulation of target gene Chk1 contributes to the progression of cervical cancer; Moreover miR-424 expression levels were inversely correlated with Chk1 and p-Chk1 protein levels in both cervical cancer and normal tissues; Furthermore RNAi-mediated knockdown of Chk1 decreased matrix metalloproteinase 9 expression and phenocopied the tumor suppressive effects of miR-424 in cell models; Taken together our results identify a crucial tumor suppressive role of miR-424 in the progression of cervical cancer at least partly via upreglating the expression of Chk1 and p-Chk1 and suggest that miR-424 might be a candidate of prognostic predictor or an anticancer therapeutic target for cervical cancer patients progression cervical and endocervical cancer hsa-miR-199a-3p CHKA -2.3279328685682 1.04468066198593e-17 1.03066945671527 4.50639789726118e-14 MirTarget;miRNATAP -0.192706877643248 1.61020354261541e-16 NA NA NA hsa-miR-199b-3p CHKA -2.33226605401203 9.51887435273314e-18 1.03066945671527 4.50639789726118e-14 MirTarget;miRNATAP -0.19267951575685 1.54198165642724e-16 NA NA NA hsa-miR-139-5p CHMP4B -2.11299531796557 8.16407076415038e-28 0.229831862565558 0.00227297102688268 miRanda -0.139982712092724 2.71004610991836e-16 NA NA NA hsa-miR-3607-3p CHN1 -2.15518588554493 1.03390728226728e-23 0.660629966277 0.00013426256971279 MirTarget;miRNATAP -0.108144237699976 0.00374508336571469 NA NA NA hsa-miR-33b-5p CHRM3 -2.28852395459234 2.69046626645242e-22 0.639825919544099 0.0558578477040502 mirMAP -0.158865516201601 0.0163632388323253 NA NA NA hsa-miR-33b-5p CHST3 -2.28852395459234 2.69046626645242e-22 -0.197541925922359 0.301297241668114 mirMAP -0.127711398681237 0.000677854355008519 NA NA NA hsa-miR-15a-5p CHUK 0.349521211668244 0.000770735998804736 -0.19932080126218 0.00863163957240649 miRNAWalker2_validate;miRTarBase;MirTarget -0.122536038974783 0.000565424625908096 NA NA NA hsa-miR-15b-5p CHUK 0.230566941413564 0.0824765001857479 -0.19932080126218 0.00863163957240649 MirTarget -0.118017359725558 2.06238744655946e-05 NA NA NA hsa-miR-16-5p CHUK -0.398577235179603 0.000101598495180191 -0.19932080126218 0.00863163957240649 miRNAWalker2_validate;miRTarBase;MirTarget -0.150607357209835 2.62400382273556e-05 NA NA NA hsa-miR-23a-3p CHUK -0.178875974460574 0.135978273540604 -0.19932080126218 0.00863163957240649 MirTarget -0.100438227795724 0.00114468004476388 NA NA NA hsa-miR-339-5p CHUK 0.280589919878422 0.0355660282647215 -0.19932080126218 0.00863163957240649 miRanda -0.12221351609504 8.92727609693918e-06 NA NA NA hsa-miR-590-5p CHUK -0.103355559980404 0.310027295317092 -0.19932080126218 0.00863163957240649 miRanda -0.11766978557823 0.00128889069327197 NA NA NA hsa-miR-139-5p CIITA -2.11299531796557 8.16407076415038e-28 0.267952742521313 0.180108388943748 miRanda -0.116150366599016 0.0136958180095792 NA NA NA hsa-miR-139-5p CIT -2.11299531796557 8.16407076415038e-28 0.474922759349472 0.00990742942099617 miRanda -0.317138998536655 6.0362855008757e-14 NA NA NA hsa-miR-3607-3p CKAP2L -2.15518588554493 1.03390728226728e-23 3.20817035179385 1.01048229255434e-33 MirTarget -0.366327336241958 1.60006757546605e-09 NA NA NA hsa-miR-139-5p CKAP4 -2.11299531796557 8.16407076415038e-28 0.831324304717088 2.24371704954539e-11 miRanda -0.321047654424975 1.03823157711398e-30 NA NA NA hsa-miR-3607-3p CKAP4 -2.15518588554493 1.03390728226728e-23 0.831324304717088 2.24371704954539e-11 miRNATAP -0.159697181062943 2.591633880563e-09 NA NA NA hsa-miR-139-5p CKS2 -2.11299531796557 8.16407076415038e-28 1.22161912236801 9.21069810140807e-16 miRanda -0.35401902367465 6.94150423672055e-24 NA NA NA hsa-miR-139-5p CLDN4 -2.11299531796557 8.16407076415038e-28 -0.509454920088871 0.285134000643596 miRanda -0.477595248347036 1.86223050697908e-05 NA NA NA hsa-miR-139-5p CLEC5A -2.11299531796557 8.16407076415038e-28 -0.596046626685126 0.055346694069956 miRanda -0.295272207257988 5.22480588170133e-05 NA NA NA hsa-miR-33b-5p CLIP2 -2.28852395459234 2.69046626645242e-22 0.6241982550792 0.00363613390848369 mirMAP -0.102254764390849 0.0162520857678366 NA NA NA hsa-miR-33b-5p CLSPN -2.28852395459234 2.69046626645242e-22 2.7969110828425 3.03477840103e-20 MirTarget -0.34351269731027 3.02858663883535e-08 NA NA NA hsa-miR-424-5p CLSPN -2.62653257498508 2.38997974737991e-50 2.7969110828425 3.03477840103e-20 MirTarget -0.349119842922894 6.27087628743056e-06 NA NA NA hsa-miR-139-5p CLVS1 -2.11299531796557 8.16407076415038e-28 1.90697560004814 1.02365212947429e-06 MirTarget;miRanda -0.373325927025302 5.63198735828939e-05 NA NA NA hsa-miR-199a-3p CNIH2 -2.3279328685682 1.04468066198593e-17 1.46077555894261 7.82055795325686e-11 MirTarget;PITA;miRNATAP -0.169119008328234 1.65227707914565e-05 NA NA NA hsa-miR-199b-3p CNIH2 -2.33226605401203 9.51887435273314e-18 1.46077555894261 7.82055795325686e-11 MirTarget;PITA;miRNATAP -0.168922199609321 1.66698057888229e-05 NA NA NA hsa-miR-424-5p CNIH2 -2.62653257498508 2.38997974737991e-50 1.46077555894261 7.82055795325686e-11 miRNATAP -0.287292602475879 2.35158832280348e-07 NA NA NA hsa-miR-139-5p CNIH4 -2.11299531796557 8.16407076415038e-28 1.00667194671376 1.24728003967923e-20 miRanda -0.219418045097645 1.33961575556005e-17 NA NA NA hsa-miR-3607-3p CNIH4 -2.15518588554493 1.03390728226728e-23 1.00667194671376 1.24728003967923e-20 mirMAP -0.106439265984283 1.01424411043428e-05 NA NA NA hsa-miR-424-5p CNIH4 -2.62653257498508 2.38997974737991e-50 1.00667194671376 1.24728003967923e-20 miRNAWalker2_validate -0.229326731340969 7.34156013997293e-18 NA NA NA hsa-miR-33b-5p CNNM1 -2.28852395459234 2.69046626645242e-22 0.33952854155628 0.46753682532046 miRNATAP -0.236465922801481 0.010345858231274 NA NA NA hsa-miR-139-5p CNPY2 -2.11299531796557 8.16407076415038e-28 0.421559448029404 4.41276004905492e-06 miRanda -0.105844647270619 9.41112396251402e-07 NA NA NA hsa-miR-144-3p CNTD1 -2.97536914478815 6.00546047309683e-28 0.860503968809642 1.69875217549702e-10 MirTarget -0.104193547886273 5.21239596355741e-06 NA NA NA hsa-miR-10b-3p CNTN3 2.77189254628215 2.26687582932628e-20 -3.79474041317988 4.05922553370655e-14 MirTarget;miRNATAP -0.463091444507399 6.44231144984469e-08 NA NA NA hsa-miR-139-5p CNTNAP4 -2.11299531796557 8.16407076415038e-28 2.12595172710381 4.22934493931606e-05 miRanda -0.462814987027133 0.000167581253264256 NA NA NA hsa-miR-3607-3p COG2 -2.15518588554493 1.03390728226728e-23 0.955520053042431 2.26046256925553e-26 MirTarget;miRNATAP -0.116205863797297 8.40610493842052e-09 NA NA NA hsa-miR-144-3p COL10A1 -2.97536914478815 6.00546047309683e-28 -0.471405266214636 0.270922521999975 miRNATAP -0.239960428061586 0.000793382631713078 NA NA NA hsa-miR-139-5p COL11A1 -2.11299531796557 8.16407076415038e-28 1.54551268520343 0.000618478933133262 miRanda -0.47590688141087 7.46428085697108e-06 NA NA NA hsa-miR-3607-3p COL8A1 -2.15518588554493 1.03390728226728e-23 0.572127506453538 0.049047573118601 mirMAP -0.190148078013837 0.00227163484474022 NA NA NA hsa-miR-424-5p COPS7B -2.62653257498508 2.38997974737991e-50 0.641973815480622 1.99581786116502e-17 MirTarget;miRNATAP -0.147633247799832 1.58597114410245e-15 NA NA NA hsa-miR-10b-3p CPEB3 2.77189254628215 2.26687582932628e-20 -2.73760799365771 6.08365930201296e-43 miRNATAP -0.239346080629591 4.36977542213658e-11 NA NA NA hsa-miR-10b-3p CPEB4 2.77189254628215 2.26687582932628e-20 -1.06097838176943 9.01316045116939e-14 miRNATAP -0.104887378097972 1.69092701826956e-05 NA NA NA hsa-miR-183-5p CPLX2 2.33444328833177 1.52188109365421e-10 5.16430096205473 2.83212867957316e-12 mirMAP -0.217751487513167 0.0283292046810086 NA NA NA hsa-miR-483-3p CPLX2 -2.99328900859484 2.67538108509603e-07 5.16430096205473 2.83212867957316e-12 mirMAP -0.406125075319149 5.29071670736331e-11 NA NA NA hsa-miR-139-5p CPSF6 -2.11299531796557 8.16407076415038e-28 0.528850368138479 7.89466331012242e-16 miRanda -0.166355729950209 4.8131145933851e-29 NA NA NA hsa-miR-139-3p CPT1B -2.53151940925585 1.56777509736867e-36 0.917514494856581 1.47512766267407e-06 PITA -0.200769500596007 2.24597303786127e-06 NA NA NA hsa-miR-183-5p CR1 2.33444328833177 1.52188109365421e-10 -2.56605616284755 6.18825669692394e-18 miRNAWalker2_validate -0.118049185199016 0.00351528138094499 NA NA NA hsa-miR-10b-3p CRISPLD1 2.77189254628215 2.26687582932628e-20 -1.03442162748199 0.000105813740507252 MirTarget -0.253528506628716 1.0509046411683e-08 NA NA NA hsa-miR-139-5p CROCC -2.11299531796557 8.16407076415038e-28 0.957278449695095 3.57335065504341e-16 miRanda -0.196106600835789 2.41254087444766e-12 NA NA NA hsa-miR-107 CSF1 0.241662461253461 0.0170788899505389 -0.5853277886696 0.00153229238014141 miRanda -0.285515676631282 0.00148342702036097 NA NA NA hsa-miR-148a-3p CSF1 -0.748702855596996 3.93313343865641e-07 -0.5853277886696 0.00153229238014141 miRNATAP -0.256768312227477 2.00461329540934e-05 NA NA NA hsa-miR-17-5p CSF1 0.698861147045461 2.43854106455398e-05 -0.5853277886696 0.00153229238014141 TargetScan;miRNATAP -0.242663156767433 6.44086586924826e-06 NA NA NA hsa-miR-20a-5p CSF1 0.854326758727003 5.04256669663285e-07 -0.5853277886696 0.00153229238014141 miRNATAP -0.281846084837308 5.48117776284526e-08 NA NA NA hsa-miR-455-3p CSF1 -1.3998033821095 5.72010709806871e-17 -0.5853277886696 0.00153229238014141 mirMAP -0.11714078431287 0.0246073498421681 NA NA NA hsa-miR-93-5p CSF1 1.39518349670953 2.84167728726712e-25 -0.5853277886696 0.00153229238014141 miRNATAP -0.220842943300629 0.000492146206942775 NA NA NA hsa-miR-107 CSF1R 0.241662461253461 0.0170788899505389 -1.22973996011932 1.03080978200997e-10 miRanda -0.446705177499975 1.81867568630625e-06 NA NA NA hsa-miR-34a-5p CSF1R 1.03694231790865 5.74864019540594e-14 -1.22973996011932 1.03080978200997e-10 MirTarget;miRNATAP -0.170397067894218 0.0108753863449133 NA NA NA hsa-miR-33b-5p CSMD1 -2.28852395459234 2.69046626645242e-22 3.23745692089652 4.45194111243163e-09 MirTarget -0.298456973149298 0.00720873851491615 NA NA NA hsa-miR-139-3p CSMD2 -2.53151940925585 1.56777509736867e-36 2.31943623170624 1.26374709514885e-11 MirTarget -0.357591275510781 3.84458732375736e-06 NA NA NA hsa-miR-139-5p CSNK1G1 -2.11299531796557 8.16407076415038e-28 0.5242161160821 3.26619328715997e-11 PITA -0.142571806100437 9.52676421933542e-15 NA NA NA hsa-miR-3607-3p CTHRC1 -2.15518588554493 1.03390728226728e-23 3.17822009022244 8.77701727783127e-20 MirTarget;miRNATAP -0.476610417626177 6.17956959806093e-10 NA NA NA hsa-miR-183-5p CTNNA2 2.33444328833177 1.52188109365421e-10 2.25787302460162 0.000155826635136281 MirTarget;miRNATAP -0.267080612735119 0.00064396812606403 NA NA NA hsa-miR-199a-3p CTNNA2 -2.3279328685682 1.04468066198593e-17 2.25787302460162 0.000155826635136281 MirTarget -0.521228083201561 3.46304846039583e-07 NA NA NA hsa-miR-199b-3p CTNNA2 -2.33226605401203 9.51887435273314e-18 2.25787302460162 0.000155826635136281 MirTarget -0.521575116257334 3.33225244965853e-07 NA NA NA hsa-miR-3607-3p CTNND2 -2.15518588554493 1.03390728226728e-23 -1.18454154034261 0.0540804866207506 miRNATAP -0.569551351649642 1.39172642610075e-05 NA NA NA hsa-miR-139-5p CTSC -2.11299531796557 8.16407076415038e-28 0.237981093984275 0.171373931043568 miRanda -0.214369486636104 1.17269426801553e-07 NA NA NA hsa-miR-139-5p CTTN -2.11299531796557 8.16407076415038e-28 0.552160468124392 7.49013837945227e-13 miRanda -0.113208446402289 5.42852456271954e-10 NA NA NA hsa-miR-139-3p CTU1 -2.53151940925585 1.56777509736867e-36 0.641434244250251 6.05291743112683e-07 MirTarget -0.130645613692313 5.13595835824764e-06 NA NA NA hsa-miR-424-5p CUEDC1 -2.62653257498508 2.38997974737991e-50 0.930881262265448 8.48699763636032e-12 mirMAP -0.102145692583804 0.00276505853641416 NA NA NA hsa-miR-139-5p CWC27 -2.11299531796557 8.16407076415038e-28 0.506202855821902 1.74367879234405e-13 miRanda -0.144300580701233 9.26486781866545e-20 NA NA NA hsa-miR-139-5p CXCL17 -2.11299531796557 8.16407076415038e-28 1.16105911093031 0.00599835694949317 miRanda -0.361064191089026 0.000288147793050695 NA NA NA hsa-miR-224-5p CXCR2 2.67175249172213 1.46995328399796e-18 -2.68926419241537 7.5073770266109e-24 MirTarget -0.180030168022453 2.97957923902654e-05 NA NA NA hsa-miR-424-5p CYB561D1 -2.62653257498508 2.38997974737991e-50 1.35618855619484 4.53684308721849e-24 mirMAP -0.231278902741091 8.97300791774464e-12 NA NA NA hsa-miR-183-5p CYB5D2 2.33444328833177 1.52188109365421e-10 -1.05044582469996 2.20332036223708e-14 miRNAWalker2_validate -0.152219752576404 1.2736576600128e-17 NA NA NA hsa-miR-144-3p CYTH3 -2.97536914478815 6.00546047309683e-28 0.609753795487233 1.49167558303658e-06 MirTarget -0.101444968146752 1.80919741595837e-06 NA NA NA hsa-miR-3607-3p CYTH3 -2.15518588554493 1.03390728226728e-23 0.609753795487233 1.49167558303658e-06 MirTarget -0.121203610749447 8.65046325600329e-06 NA NA NA hsa-miR-139-5p CYTH4 -2.11299531796557 8.16407076415038e-28 -0.0320490491804084 0.851298391951766 miRanda -0.154901906921489 0.000108832822181886 NA NA NA hsa-miR-183-5p DAAM1 2.33444328833177 1.52188109365421e-10 -0.820319075229238 3.16122030911227e-05 MirTarget;miRNATAP -0.109601186169797 2.10092575174277e-05 NA NA NA hsa-miR-139-5p DAB2 -2.11299531796557 8.16407076415038e-28 -0.0812678108323723 0.659390389044208 miRanda -0.11332759076699 0.00900759583877607 NA NA NA hsa-miR-10b-3p DACT3 2.77189254628215 2.26687582932628e-20 -1.18615711515613 8.83350137018568e-07 mirMAP -0.268884128648898 1.75538986591591e-11 NA NA NA hsa-miR-3607-3p DAGLA -2.15518588554493 1.03390728226728e-23 1.16197262256378 7.56867119602314e-06 MirTarget;miRNATAP -0.2454312273775 1.09827521969152e-05 NA NA NA hsa-miR-3607-3p DBF4 -2.15518588554493 1.03390728226728e-23 0.924895042673626 1.9008434964275e-15 MirTarget;miRNATAP -0.157207609296571 5.40688898105347e-10 NA NA NA hsa-miR-3607-3p DBN1 -2.15518588554493 1.03390728226728e-23 1.22908274202267 1.07132266803334e-08 MirTarget;miRNATAP -0.175173380979955 0.000176306447636288 NA NA NA hsa-miR-139-5p DCAF4L1 -2.11299531796557 8.16407076415038e-28 1.82732435390596 2.33240027694037e-14 miRanda -0.338443121007232 3.67975696520554e-09 NA NA NA hsa-miR-3607-3p DCLRE1C -2.15518588554493 1.03390728226728e-23 0.908570621722367 3.1033140691977e-11 MirTarget -0.117606850442672 8.23941717764088e-05 NA NA NA hsa-miR-139-5p DCTN2 -2.11299531796557 8.16407076415038e-28 0.636498033844521 1.38865077532974e-21 miRanda -0.166825416703306 2.79613288087363e-27 NA NA NA hsa-miR-10b-3p DDR1 2.77189254628215 2.26687582932628e-20 0.19463335306942 0.483361341487924 mirMAP -0.138683926464681 0.00278028030291743 NA NA NA hsa-miR-139-5p DDX11 -2.11299531796557 8.16407076415038e-28 1.44752503641813 4.09048996563645e-17 miRanda -0.383680971272358 1.28693936623637e-21 NA NA NA hsa-miR-424-5p DEDD -2.62653257498508 2.38997974737991e-50 0.612188783756723 5.73061297884285e-19 miRNATAP -0.146553444821278 2.54564072336107e-18 NA NA NA hsa-miR-424-5p DEF8 -2.62653257498508 2.38997974737991e-50 0.614076798619747 3.82744235570261e-11 MirTarget -0.159709708573961 1.64169783824352e-12 NA NA NA hsa-miR-139-5p DENND1B -2.11299531796557 8.16407076415038e-28 0.184119225845451 0.312131121857309 miRanda -0.109392423850093 0.0107668227760079 NA NA NA hsa-miR-139-5p DENR -2.11299531796557 8.16407076415038e-28 0.3542544253519 1.71077585620851e-08 miRanda;miRNATAP -0.139556289464424 6.97636876210179e-23 NA NA NA hsa-miR-139-5p DEPDC1 -2.11299531796557 8.16407076415038e-28 3.91941399081965 9.23089152894088e-45 miRanda -0.894311882941788 4.06096361115932e-41 NA NA NA hsa-miR-199a-3p DEPDC1B -2.3279328685682 1.04468066198593e-17 2.81995289547286 3.64152756583752e-21 MirTarget;miRNATAP -0.200678887454134 0.000192299453302248 NA NA NA hsa-miR-199b-3p DEPDC1B -2.33226605401203 9.51887435273314e-18 2.81995289547286 3.64152756583752e-21 MirTarget -0.200628481297659 0.000190949693998044 NA NA NA hsa-miR-424-5p DGCR2 -2.62653257498508 2.38997974737991e-50 0.480917046414169 4.64032272088744e-09 mirMAP -0.120994456621259 1.46071968156707e-09 NA NA NA hsa-miR-424-5p DGKD -2.62653257498508 2.38997974737991e-50 0.711034021867333 8.46501341224824e-13 mirMAP -0.144755314043045 3.64225034268185e-09 NA NA NA hsa-miR-3607-3p DGKZ -2.15518588554493 1.03390728226728e-23 0.732808180745531 1.57387360194658e-17 MirTarget;miRNATAP -0.118878678234218 2.35572446386791e-10 NA NA NA hsa-miR-10b-3p DHTKD1 2.77189254628215 2.26687582932628e-20 -1.32230535079254 3.83125025947273e-15 MirTarget -0.10276507081117 0.000401867816148917 NA NA NA hsa-miR-3607-3p DIO2 -2.15518588554493 1.03390728226728e-23 1.74798259848111 3.86024401348235e-05 mirMAP -0.230520435992937 0.0121468126887121 NA NA NA hsa-miR-139-5p DIRAS2 -2.11299531796557 8.16407076415038e-28 -1.05583409954761 0.0115059744004503 miRanda -0.249601749384818 0.0115312459850831 NA NA NA hsa-miR-3607-3p DKK2 -2.15518588554493 1.03390728226728e-23 0.712159035258033 0.0313122411685687 miRNATAP -0.220648396449356 0.00186051493970931 NA NA NA hsa-miR-139-5p DLG5 -2.11299531796557 8.16407076415038e-28 1.50511854034316 3.93408903539969e-21 miRanda -0.279765827538303 3.56882181880895e-13 NA NA NA hsa-miR-144-3p DLG5 -2.97536914478815 6.00546047309683e-28 1.50511854034316 3.93408903539969e-21 MirTarget;miRNATAP -0.178541076326771 8.65500445465138e-11 NA NA NA hsa-miR-424-5p DLL4 -2.62653257498508 2.38997974737991e-50 1.07379585219093 2.85322047024912e-15 miRNATAP -0.12760985044512 0.000195990057682133 NA NA NA hsa-miR-139-5p DLX5 -2.11299531796557 8.16407076415038e-28 1.7796725834344 1.28017204783704e-07 miRanda -0.454473605580934 1.05857937515388e-08 NA NA NA hsa-miR-199a-3p DLX5 -2.3279328685682 1.04468066198593e-17 1.7796725834344 1.28017204783704e-07 PITA -0.158914950246505 0.00690203951913021 NA NA NA hsa-miR-199b-3p DLX5 -2.33226605401203 9.51887435273314e-18 1.7796725834344 1.28017204783704e-07 PITA -0.159327027654146 0.00671682194433778 NA NA NA hsa-miR-3607-3p DLX5 -2.15518588554493 1.03390728226728e-23 1.7796725834344 1.28017204783704e-07 miRNATAP -0.333177784288525 4.65688041355625e-06 NA NA NA hsa-miR-424-5p DMTF1 -2.62653257498508 2.38997974737991e-50 0.720174800916112 3.26736447643672e-14 MirTarget;miRNATAP -0.109448007644922 3.87208148133475e-06 NA NA NA hsa-miR-139-5p DNAH12 -2.11299531796557 8.16407076415038e-28 1.57987976878219 2.38269051016968e-05 miRanda -0.284309367390816 0.00136758591747859 NA NA NA hsa-miR-139-5p DNAJC10 -2.11299531796557 8.16407076415038e-28 0.47966292098659 5.25506289560147e-07 miRanda -0.161062400846041 3.62502899500546e-13 NA NA NA hsa-miR-139-5p DNAJC18 -2.11299531796557 8.16407076415038e-28 0.379578184862879 0.00785785435417525 miRanda -0.145371187053377 1.40951791372187e-05 NA NA NA hsa-miR-33b-5p DNAJC18 -2.28852395459234 2.69046626645242e-22 0.379578184862879 0.00785785435417525 mirMAP -0.132814730007361 2.05710204364669e-06 NA NA NA hsa-miR-139-5p DNAJC5 -2.11299531796557 8.16407076415038e-28 0.729723241275518 1.53708391771805e-17 MirTarget;PITA;miRanda;miRNATAP -0.196656809291349 3.93357632136847e-23 NA NA NA hsa-miR-183-5p DNALI1 2.33444328833177 1.52188109365421e-10 -1.66219586705874 3.07598200324114e-08 MirTarget -0.222048850263152 1.53002934356951e-08 NA NA NA hsa-miR-139-5p DNER -2.11299531796557 8.16407076415038e-28 1.29255242782277 0.00336209766653278 miRanda -0.528073518872461 3.05735145973779e-07 NA NA NA hsa-miR-139-5p DNM1L -2.11299531796557 8.16407076415038e-28 0.461545461792854 3.707783316895e-10 miRanda -0.113949298420425 4.07317290871042e-11 NA NA NA hsa-miR-3607-3p DNM3 -2.15518588554493 1.03390728226728e-23 1.36736147579245 1.02047986055836e-15 mirMAP -0.213374570515971 1.05469614313224e-08 NA NA NA hsa-miR-139-5p DNMT3A -2.11299531796557 8.16407076415038e-28 1.18820126942617 6.93286101815213e-19 miRanda -0.3514536371175 1.96019813828168e-30 NA NA NA hsa-miR-144-3p DNMT3A -2.97536914478815 6.00546047309683e-28 1.18820126942617 6.93286101815213e-19 miRNATAP -0.185122947894158 2.62661327518311e-16 NA NA NA hsa-miR-199a-3p DNMT3A -2.3279328685682 1.04468066198593e-17 1.18820126942617 6.93286101815213e-19 MirTarget;PITA;miRNATAP -0.128565104280402 5.98009906284426e-08 NA NA NA hsa-miR-199b-3p DNMT3A -2.33226605401203 9.51887435273314e-18 1.18820126942617 6.93286101815213e-19 MirTarget;PITA;miRNATAP -0.128612103942248 5.77959830502394e-08 NA NA NA hsa-miR-3607-3p DNMT3A -2.15518588554493 1.03390728226728e-23 1.18820126942617 6.93286101815213e-19 MirTarget;miRNATAP -0.20473855064896 2.51770421133447e-12 NA NA NA hsa-miR-3607-3p DNMT3B -2.15518588554493 1.03390728226728e-23 1.61793226634891 7.24162651287187e-19 mirMAP -0.255549159975494 1.78981699184164e-10 NA NA NA hsa-miR-139-5p DOCK3 -2.11299531796557 8.16407076415038e-28 1.89917396490138 8.65073654235979e-17 miRanda -0.364872211824438 2.59669504534924e-11 NA NA NA hsa-miR-424-5p DOT1L -2.62653257498508 2.38997974737991e-50 0.585703387018246 2.71031330751421e-07 mirMAP -0.111637540866011 6.86982793392546e-05 NA NA NA hsa-miR-139-5p DRAM1 -2.11299531796557 8.16407076415038e-28 0.347902515184351 0.00455531141164128 miRanda -0.248266806975004 3.45458261509955e-19 NA NA NA hsa-miR-33b-5p DRAM1 -2.28852395459234 2.69046626645242e-22 0.347902515184351 0.00455531141164128 mirMAP -0.107946535679068 7.21896986888847e-06 NA NA NA hsa-miR-139-5p DSN1 -2.11299531796557 8.16407076415038e-28 1.20856486772601 2.10674797640793e-26 miRanda -0.266023308912083 8.36566584394534e-23 NA NA NA hsa-miR-144-3p DSTYK -2.97536914478815 6.00546047309683e-28 1.00504202460505 2.41375496861128e-19 miRNATAP -0.169205339629299 1.58194513212483e-19 NA NA NA hsa-miR-144-3p DTNA -2.97536914478815 6.00546047309683e-28 1.85440917822318 1.2434230849807e-10 MirTarget;miRNATAP -0.169658382527851 0.000574862234707834 NA NA NA hsa-miR-199a-3p DTNA -2.3279328685682 1.04468066198593e-17 1.85440917822318 1.2434230849807e-10 PITA;miRNATAP -0.105155567629189 0.0384704269797366 NA NA NA hsa-miR-199b-3p DTNA -2.33226605401203 9.51887435273314e-18 1.85440917822318 1.2434230849807e-10 PITA;miRNATAP -0.105474371185927 0.0377447473717664 NA NA NA hsa-miR-224-5p DUSP16 2.67175249172213 1.46995328399796e-18 -0.91339878293532 2.52773648393564e-12 MirTarget -0.114433159809114 1.53140699846969e-08 NA NA NA hsa-miR-139-5p DUSP18 -2.11299531796557 8.16407076415038e-28 0.521402838825816 1.31734329988244e-05 miRanda -0.195500033753096 1.75700789008846e-12 NA NA NA hsa-miR-183-5p DYNC1I1 2.33444328833177 1.52188109365421e-10 1.66864494169359 1.46552904583527e-05 MirTarget -0.122722119976231 0.0156508359797428 NA NA NA hsa-miR-424-5p DYNC1I1 -2.62653257498508 2.38997974737991e-50 1.66864494169359 1.46552904583527e-05 MirTarget;miRNATAP -0.383470099938087 5.03133442030565e-05 NA NA NA hsa-miR-139-5p DYNC2LI1 -2.11299531796557 8.16407076415038e-28 0.33945373719519 5.25531155032593e-05 miRanda -0.107774849644694 3.74557548441722e-08 NA NA NA hsa-miR-139-5p DYRK2 -2.11299531796557 8.16407076415038e-28 0.389542654251892 0.00213564801591695 PITA;miRanda -0.200901740918086 6.74920610523705e-12 NA NA NA hsa-miR-3607-3p DYRK2 -2.15518588554493 1.03390728226728e-23 0.389542654251892 0.00213564801591695 mirMAP -0.138093657569458 2.99991291819338e-07 NA NA NA hsa-miR-139-5p DZIP1L -2.11299531796557 8.16407076415038e-28 -0.0817102374066513 0.728597088782924 miRanda -0.224653966033926 4.57827860459817e-05 NA NA NA hsa-miR-139-5p DZIP3 -2.11299531796557 8.16407076415038e-28 0.6477896485534 9.3594563775493e-10 miRanda -0.113934234384623 6.18264232097205e-06 NA NA NA hsa-miR-139-5p E2F7 -2.11299531796557 8.16407076415038e-28 3.06815276582178 3.19808997821633e-30 miRanda -0.689666179853745 4.44543853418596e-27 NA NA NA hsa-miR-424-5p E2F7 -2.62653257498508 2.38997974737991e-50 3.06815276582178 3.19808997821633e-30 miRNATAP -0.511049362578655 1.08685097634745e-13 25708247 MicroRNA 424 may function as a tumor suppressor in endometrial carcinoma cells by targeting E2F7; Bioinformatics analysis indicated that E2F7 was a putative target of miR-424; In a luciferase reporter system we confirmed that E2F7 was a direct target gene of miR-424; These findings indicate that miR-424 targets the E2F7 transcript and suppresses endometrial cancer cell growth suggesting that miR-424 has a tumor suppressive role in human endometrial cancer pathogenesis endometrial cancer hsa-miR-139-5p E2F8 -2.11299531796557 8.16407076415038e-28 3.82257627150129 4.96698856709543e-39 miRanda -0.833683930329718 1.96859305381064e-32 NA NA NA hsa-miR-144-3p E2F8 -2.97536914478815 6.00546047309683e-28 3.82257627150129 4.96698856709543e-39 MirTarget;miRNATAP -0.36819404978957 2.76411231248021e-12 NA NA NA hsa-miR-144-3p EBF1 -2.97536914478815 6.00546047309683e-28 1.93068987874298 7.85878306597582e-25 miRNATAP -0.174334079704007 1.23267298426518e-07 NA NA NA hsa-miR-33b-5p EBF1 -2.28852395459234 2.69046626645242e-22 1.93068987874298 7.85878306597582e-25 miRNATAP -0.213026068151103 4.00810209667565e-08 NA NA NA hsa-miR-139-5p EDC3 -2.11299531796557 8.16407076415038e-28 0.728251649618274 7.59128130821528e-26 MirTarget;miRanda -0.163423689596321 1.79961086946292e-23 NA NA NA hsa-miR-3607-3p EFHC1 -2.15518588554493 1.03390728226728e-23 0.848078375402764 8.29240893300235e-12 miRNATAP -0.125296091397845 3.567582706423e-06 NA NA NA hsa-miR-30c-2-3p EFNA1 -1.39811819128587 3.66376924527665e-15 0.646825904608858 3.64944927546855e-05 MirTarget -0.234024324762841 1.39767068736484e-08 NA NA NA hsa-miR-326 EFNA1 -1.881935132554 1.68087316863775e-21 0.646825904608858 3.64944927546855e-05 miRanda -0.140434021609749 0.000161056439179517 NA NA NA hsa-miR-486-5p EFNA1 -1.77766890600022 2.9071717929922e-14 0.646825904608858 3.64944927546855e-05 miRanda -0.149419446907336 2.19123125151434e-06 NA NA NA hsa-miR-145-5p EFNA3 -1.4795885711477 6.47308361543414e-16 1.74857523726189 1.89670377349898e-17 miRNATAP -0.27893442549449 2.94867753331604e-07 NA NA NA hsa-miR-27b-3p EFNA3 -0.823491817819754 9.20935302746823e-14 1.74857523726189 1.89670377349898e-17 miRNATAP -0.583190806894562 1.14503674353614e-10 NA NA NA hsa-miR-30a-5p EFNA3 -0.626257932887855 0.000108198196973765 1.74857523726189 1.89670377349898e-17 MirTarget;mirMAP;miRNATAP -0.324845227158913 3.1494534591563e-07 NA NA NA hsa-miR-30c-5p EFNA3 -0.432111642767632 0.000159764714931007 1.74857523726189 1.89670377349898e-17 MirTarget;mirMAP;miRNATAP -0.272889750837349 0.00277347446519368 NA NA NA hsa-miR-30e-5p EFNA3 -0.627815042856657 3.02205690184908e-10 1.74857523726189 1.89670377349898e-17 MirTarget;mirMAP -0.485030662588513 2.3026107671749e-06 NA NA NA hsa-miR-326 EFNA3 -1.881935132554 1.68087316863775e-21 1.74857523726189 1.89670377349898e-17 MirTarget;miRanda;miRNATAP -0.176452904716396 0.000484752208263276 NA NA NA hsa-miR-342-5p EFNA3 -0.780720763816797 5.21703298730986e-07 1.74857523726189 1.89670377349898e-17 miRNATAP -0.194650872773775 0.00339775056957733 NA NA NA hsa-miR-3607-3p EFNA3 -2.15518588554493 1.03390728226728e-23 1.74857523726189 1.89670377349898e-17 mirMAP;miRNATAP -0.201114949852214 1.03301411116055e-05 NA NA NA hsa-miR-486-5p EFNA3 -1.77766890600022 2.9071717929922e-14 1.74857523726189 1.89670377349898e-17 miRanda -0.222051028105411 2.00549553126369e-07 NA NA NA hsa-miR-140-5p EFNA4 -0.220106443070144 0.0140713197101242 1.47899606476918 8.0933783233146e-26 PITA;miRanda -0.169579866093741 0.0400434514913174 NA NA NA hsa-miR-1976 EFNA4 -0.431472440543166 0.00324575010550946 1.47899606476918 8.0933783233146e-26 MirTarget -0.18479067692524 0.000194314415527299 NA NA NA hsa-miR-26b-5p EFNA4 -1.10804856399744 4.14176110314282e-22 1.47899606476918 8.0933783233146e-26 miRNAWalker2_validate -0.351313032976239 4.29536860806307e-09 NA NA NA hsa-miR-101-3p EFNA5 -1.48176407980989 3.98950707385704e-31 -1.35514027226431 0.000692469246595569 miRNATAP -0.628698296210383 9.0433663712587e-06 NA NA NA hsa-miR-1269a EFNA5 3.57543539205634 4.25369619949175e-08 -1.35514027226431 0.000692469246595569 mirMAP -0.118790518480963 0.000117551955405591 NA NA NA hsa-miR-19a-3p EFNA5 1.01712596153672 2.57753201450625e-07 -1.35514027226431 0.000692469246595569 miRNATAP -0.279630002756674 0.0042407624166513 NA NA NA hsa-miR-19b-3p EFNA5 0.601279551368824 0.00016685097085251 -1.35514027226431 0.000692469246595569 miRNATAP -0.40467492977246 0.00088980599521387 NA NA NA hsa-miR-204-5p EFNA5 -0.537962150012103 0.0330895493358849 -1.35514027226431 0.000692469246595569 miRNATAP -0.393603225156653 2.80940732573529e-07 NA NA NA hsa-miR-20a-3p EFNA5 -0.318177901603857 0.0467885456739855 -1.35514027226431 0.000692469246595569 mirMAP -0.246165406426135 0.0452846592245223 NA NA NA hsa-miR-28-5p EFNA5 -0.430964830599964 2.67367257252925e-06 -1.35514027226431 0.000692469246595569 PITA;miRNATAP -0.961268745350365 5.76123363646996e-06 NA NA NA hsa-miR-32-3p EFNA5 0.219109440121582 0.207217051619543 -1.35514027226431 0.000692469246595569 mirMAP -0.398640476166263 0.000613468003303945 NA NA NA hsa-miR-33a-3p EFNA5 -0.683025859637737 1.01106097756419e-05 -1.35514027226431 0.000692469246595569 mirMAP -0.256186219779556 0.0421085487522157 NA NA NA hsa-miR-362-3p EFNA5 0.814007335895913 2.00108618836568e-09 -1.35514027226431 0.000692469246595569 miRanda -0.406503595240295 0.00419808680650827 NA NA NA hsa-miR-378a-3p EFNA5 -1.1920055906972 3.23538871733634e-10 -1.35514027226431 0.000692469246595569 miRNATAP -0.371127828088677 0.000229858039216613 NA NA NA hsa-miR-378c EFNA5 -1.54028191929038 2.70131554214866e-15 -1.35514027226431 0.000692469246595569 miRNATAP -0.259859617515804 0.00742413150669568 NA NA NA hsa-miR-92a-3p EFNA5 0.212391012518195 0.134292268089997 -1.35514027226431 0.000692469246595569 miRNAWalker2_validate -0.490918489487089 0.000381023755947929 NA NA NA hsa-miR-146a-5p EGFR -0.742958238440575 0.000765983177482633 -1.01672920195188 6.69873186671412e-07 miRNAWalker2_validate -0.224421920698198 6.22524592924969e-07 24895573;25242818;22161865;25596948;25417703;23555954;24839931;21632853 Furthermore western blot showed that miR-146a mimic downregulated EGFR ERK1/2 and stat5 signalings; These effects were less potent compared to that of a siRNA targeting EGFR a known target gene of miR-146a; Moreover miR-146a mimic could enhance the cell growth inhibition and apoptosis induction impact of various EGFR targeting agents;Interestingly re-expression of miR-146a inhibited the invasive capacity of Colo357 and Panc-1 PC cells with concomitant down-regulation of EGFR and IRAK-1; Most importantly we found that the treatment of PC cells with "natural agents" 33'-diinodolylmethane DIM or isoflavone led to an increase in the expression of miR-146a and consequently down-regulated the expression of EGFR MTA-2 IRAK-1 and NF-κB resulting in the inhibition of invasion of Colo357 and Panc-1 cells;MiR 146a suppresses tumor growth and progression by targeting EGFR pathway and in a p ERK dependent manner in castration resistant prostate cancer; Mechanistic studies revealed that miR-146a repressed the expression of EGFR through binding to its 3'-untranslated region; Our findings suggest that ubiquitous loss of miR-146a is a critical mechanism for overexpression of EGFR in CRPC which is crucial to better understanding the pathogenesis of CRPC;Furthermore the expressions of bax and cleaved-caspase-3 mainly were increased in control and overexpression miR-146a groups however the expression of EGFR was inverse; All the results demonstrated that quercetin exhibited excellent effect on inhibiting cell proliferation in human breast cancer cells which was performed by up-regulating miR-146a expression then via inducing apoptosis through caspase-3 activation and mitochondrial-dependent pathways and inhibiting invasion through down-regulating the expression of EGFR;Here we report a previously unrecognized posttranscriptional mechanism by which BRCA1 regulates EGFR expression through the induction of miR-146a; We show that BRCA1 binds to MIR146A promoter and activates transcription which in turn attenuates EGFR expression;In functional experiments miR-146a suppressed cell growth induced cellular apoptosis and inhibited EGFR downstream signaling in five NSCLC cell lines H358 H1650 H1975 HCC827 and H292 miR-146a also inhibited the migratory capacity of these NSCLC cells; On the other hand miR-146a enhanced the inhibition of cell proliferation by drugs targeting EGFR including both TKIs gefitinib erlotinib and afatinib and a monoclonal antibody cetuximab; Our results suggest that these effects of miR-146a are due to its targeting of EGFR and NF-κB signaling;Deregulation of miR 146a expression in a mouse model of pancreatic cancer affecting EGFR signaling; Treatment of PC cells with CDF a novel synthetic compound led to re-expression of miR-146a resulting in the down-regulation of EGFR expression; Further knock-down of miR-146a in AsPC-1 cells led to the up-regulation of EGFR expression and showed increased clonogenic growth; In addition knock-down of EGFR by EGFR siRNA transfection of parental AsPC-1 cells and AsPC-1 cells stably transfected with pre-miR-146a resulted in decreased invasive capacity which was further confirmed by reduced luciferase activity in cells transfected with pMIR-Luc reporter vector containing miR-146a binding site; Collectively these results suggest that the loss of expression of miR-146a is a fundamental mechanism for over-expression of EGFR signaling and that re-expression of miR-146a by CDF treatment could be useful in designing personalized strategy for the treatment of human PC;The regulation of EGFR and IRAK1 by miR-146a was examined with miR-146a-transfected gastric cancer cells; Ectopic expression of miR-146a inhibited migration and invasion and downregulated EGFR and IRAK1 expression in gastric cancer cells; MiR-146a targeting of EGFR and IRAK1 is an independent prognostic factor in gastric cancer cases ;;progression;;;;; liver cancer;pancreatic cancer;prostate cancer;breast cancer;breast cancer;lung squamous cell cancer;pancreatic cancer;gastric cancer hsa-miR-146b-5p EGFR 0.419719546795449 0.0457375823220155 -1.01672920195188 6.69873186671412e-07 miRNATAP -0.221138858293073 3.44879306513365e-06 NA NA NA hsa-miR-148b-5p EGFR 0.295777213389605 0.0255749859535438 -1.01672920195188 6.69873186671412e-07 mirMAP -0.233539600600063 0.00227279523782391 NA NA NA hsa-miR-155-5p EGFR 0.0108524225071784 0.95651331033505 -1.01672920195188 6.69873186671412e-07 miRNAWalker2_validate;MirTarget -0.128466970088693 0.0115801509528144 NA NA NA hsa-miR-17-5p EGFR 0.698861147045461 2.43854106455398e-05 -1.01672920195188 6.69873186671412e-07 TargetScan -0.161590563481239 0.00764134099999989 NA NA NA hsa-miR-188-5p EGFR 1.11646899351496 9.56686958408598e-11 -1.01672920195188 6.69873186671412e-07 mirMAP -0.300235014857475 1.22424681244032e-07 NA NA NA hsa-miR-21-5p EGFR 1.51084295924322 1.54551622173259e-34 -1.01672920195188 6.69873186671412e-07 miRNAWalker2_validate;miRTarBase -0.440371363258275 3.21604130567409e-09 24198203;20113523;24012640;24331411;26563758;19597153;26026961;20048743 In radically resected NSCLC patients the expression levels of miR-21 10b in patients with EGFR mutation were much higher than those without mutation;Thus the miR-21 inhibitor might interrupt the activity of EGFR pathways independently of PTEN status;Further the expression of miR-21 is regulated by EGFR via the activation of β-catenin and AP-1; These data indicate that a feedback loop exists between miR-21 and EGFR; These results clarify a novel association between miR-21 and EGFR in the regulation of cancer cell progression;MiR 21 overexpression is associated with acquired resistance of EGFR TKI in non small cell lung cancer;Higher expression levels of miR-21 AmiR-27a and miR-218 detected in this study suggest potential roles of these miRNAs in primary resistance to EGFR-TKI in advanced NSCLC patients with EGFR exon 19 deletion mutations;MiR 21 is an EGFR regulated anti apoptotic factor in lung cancer in never smokers; The changes in expression of some of these miRNAs including miR-21 were more remarkable in cases with EGFR mutations than in those without these mutations; In the never-smoker-derived lung adenocarcinoma cell line H3255 with mutant EGFR and high levels of p-EGFR and miR-21 antisense inhibition of miR-21 enhanced AG1478-induced apoptosis; In a never-smoker-derived adenocarcinoma cell line H441 with wild-type EGFR the antisense miR-21 not only showed the additive effect with AG1478 but also induced apoptosis by itself; These results suggest that aberrantly increased expression of miR-21 which is enhanced further by the activated EGFR signaling pathway plays a significant role in lung carcinogenesis in never-smokers as well as in smokers and is a potential therapeutic target in both EGFR-mutant and wild-type cases;Nickel may contribute to EGFR mutation and synergistically promotes tumor invasion in EGFR mutated lung cancer via nickel induced microRNA 21 expression;Downregulation of miR 21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status ;;progression;drug resistance;staging;drug resistance;tumorigenesis;; lung squamous cell cancer;glioblastoma;glioblastoma;lung squamous cell cancer;lung squamous cell cancer;lung cancer;lung cancer;glioblastoma hsa-miR-29a-5p EGFR -0.113555908626946 0.349622266470788 -1.01672920195188 6.69873186671412e-07 mirMAP -0.458889085026057 2.82252978142708e-08 27477273 Feedback Loop Regulation of SCAP/SREBP 1 by miR 29 Modulates EGFR Signaling Driven Glioblastoma Growth glioblastoma hsa-miR-32-3p EGFR 0.219109440121582 0.207217051619543 -1.01672920195188 6.69873186671412e-07 mirMAP -0.238124126347676 6.9947851263588e-05 NA NA NA hsa-miR-362-5p EGFR 0.717921690799312 1.68392734504524e-05 -1.01672920195188 6.69873186671412e-07 mirMAP -0.247853042376492 3.33470814837779e-05 NA NA NA hsa-miR-3682-3p EGFR 0.805600143458555 8.7874424633131e-06 -1.01672920195188 6.69873186671412e-07 mirMAP -0.12932547288846 0.0249956294814211 NA NA NA hsa-miR-374b-3p EGFR -0.137420230218985 0.305318192448799 -1.01672920195188 6.69873186671412e-07 mirMAP -0.202869152527087 0.00750806275200147 NA NA NA hsa-miR-455-5p EGFR -0.270546034117157 0.0581320703577731 -1.01672920195188 6.69873186671412e-07 miRanda -0.226922724788645 0.00135818927133814 NA NA NA hsa-miR-501-5p EGFR 1.15231083477882 2.98906150004088e-10 -1.01672920195188 6.69873186671412e-07 mirMAP -0.228828416518186 2.10663471825952e-05 NA NA NA hsa-miR-590-5p EGFR -0.103355559980404 0.310027295317092 -1.01672920195188 6.69873186671412e-07 miRanda;mirMAP -0.282971808483034 0.00478577902454241 NA NA NA hsa-miR-618 EGFR 0.13539895350352 0.517145913114103 -1.01672920195188 6.69873186671412e-07 mirMAP -0.104183567265845 0.0380128909987004 NA NA NA hsa-miR-769-5p EGFR 0.219661452072771 0.0333425465750576 -1.01672920195188 6.69873186671412e-07 mirMAP -0.501593765874938 2.76004531715872e-07 NA NA NA hsa-miR-877-5p EGFR 1.35669625926821 1.43008125755656e-11 -1.01672920195188 6.69873186671412e-07 mirMAP -0.247141034396675 1.1588258665615e-06 NA NA NA hsa-miR-183-5p EGR1 2.33444328833177 1.52188109365421e-10 -3.01806133634461 3.39728821664157e-32 miRNAWalker2_validate;miRTarBase;miRNATAP -0.122377837288342 0.000675529582532134 NA NA NA hsa-miR-224-5p EGR2 2.67175249172213 1.46995328399796e-18 -2.92720452155501 5.23330307324282e-27 MirTarget -0.208502150941061 2.33546426432668e-06 NA NA NA hsa-miR-3607-3p EID2B -2.15518588554493 1.03390728226728e-23 0.87071091866513 7.74498229634601e-12 mirMAP -0.127831674940772 4.00564441624479e-06 NA NA NA hsa-miR-139-5p EIF3H -2.11299531796557 8.16407076415038e-28 0.492950905254146 6.61450873671182e-06 miRanda -0.123790522951321 1.53436170506448e-06 NA NA NA hsa-miR-139-5p ELF3 -2.11299531796557 8.16407076415038e-28 -0.125575934323432 0.573266267273914 miRanda -0.243127311446628 2.95875160572538e-06 NA NA NA hsa-miR-144-3p ELFN2 -2.97536914478815 6.00546047309683e-28 2.86706730299717 2.25493376503085e-09 miRNATAP -0.441216904505097 4.87332746489401e-08 NA NA NA hsa-miR-424-5p ELFN2 -2.62653257498508 2.38997974737991e-50 2.86706730299717 2.25493376503085e-09 mirMAP -0.430063368359669 0.000310641153342759 NA NA NA hsa-miR-3607-3p ELOVL7 -2.15518588554493 1.03390728226728e-23 -0.108433535124748 0.800367929821267 mirMAP -0.225370236870116 0.0141868183652461 NA NA NA hsa-miR-139-5p EME1 -2.11299531796557 8.16407076415038e-28 3.02905521254264 1.10248206102695e-42 MirTarget;miRanda -0.731945798736719 4.20924384252921e-45 NA NA NA hsa-miR-183-5p EMP2 2.33444328833177 1.52188109365421e-10 -0.2961927570137 0.0244099527389396 MirTarget -0.105348590939361 3.99935139576212e-10 NA NA NA hsa-miR-139-5p EMX1 -2.11299531796557 8.16407076415038e-28 2.21293111250738 1.63197126982681e-07 PITA;miRanda -0.33506104228922 0.000897708233388554 NA NA NA hsa-miR-3607-3p EN2 -2.15518588554493 1.03390728226728e-23 0.979515878391363 0.00653397638746686 MirTarget;miRNATAP -0.319760180350003 3.28116728004496e-05 NA NA NA hsa-miR-139-5p ENAH -2.11299531796557 8.16407076415038e-28 1.39629433723863 3.42757488063496e-20 PITA;miRNATAP -0.36714662251104 2.7947101609362e-25 NA NA NA hsa-miR-3607-3p ENAH -2.15518588554493 1.03390728226728e-23 1.39629433723863 3.42757488063496e-20 mirMAP -0.198194119749294 3.43422508579939e-09 NA NA NA hsa-miR-424-5p ENAH -2.62653257498508 2.38997974737991e-50 1.39629433723863 3.42757488063496e-20 MirTarget;miRNATAP -0.15849924293417 4.16251461457598e-05 NA NA NA hsa-miR-424-5p ENSA -2.62653257498508 2.38997974737991e-50 0.518318491325875 5.64872817330914e-09 miRNATAP -0.150430896235322 2.85517579377658e-12 NA NA NA hsa-miR-33b-5p ENTPD1 -2.28852395459234 2.69046626645242e-22 0.548264152440102 1.02295823309827e-09 mirMAP -0.111606995354704 2.73345608115247e-10 NA NA NA hsa-miR-3607-3p ENTPD1 -2.15518588554493 1.03390728226728e-23 0.548264152440102 1.02295823309827e-09 mirMAP -0.106679107855981 3.27243939530495e-08 NA NA NA hsa-miR-10b-5p ENTPD8 2.86931593037303 6.97409423207806e-23 -1.72840724881261 1.63795489548987e-09 mirMAP -0.195188255671237 2.15753139619002e-05 NA NA NA hsa-miR-139-5p EP400 -2.11299531796557 8.16407076415038e-28 0.478488638876872 1.17227801052593e-09 miRanda -0.131746182331623 6.66189578314255e-13 NA NA NA hsa-miR-34a-5p EPHA2 1.03694231790865 5.74864019540594e-14 -2.12469060332663 2.01316632998596e-28 miRNAWalker2_validate -0.219033843498792 0.00193427032704837 NA NA NA hsa-miR-3607-3p EPPK1 -2.15518588554493 1.03390728226728e-23 1.79105873154903 2.2482061809878e-06 MirTarget -0.398395459055103 9.72724774482667e-07 NA NA NA hsa-miR-139-5p ERMP1 -2.11299531796557 8.16407076415038e-28 0.542622265078398 5.31729874404597e-06 miRanda -0.125353526188159 8.38163751700499e-06 NA NA NA hsa-miR-10b-3p ESR1 2.77189254628215 2.26687582932628e-20 -4.11885094897542 1.63160126578307e-28 mirMAP -0.409077162663724 4.24157536100533e-10 NA NA NA hsa-miR-10b-5p ESRRG 2.86931593037303 6.97409423207806e-23 -2.51599370184769 6.04312161539017e-10 miRNATAP -0.185496902508389 0.00471949990563953 NA NA NA hsa-miR-483-3p ESRRG -2.99328900859484 2.67538108509603e-07 -2.51599370184769 6.04312161539017e-10 PITA -0.114332538739204 0.000909081615694432 NA NA NA hsa-miR-10b-3p ETS1 2.77189254628215 2.26687582932628e-20 -0.888146453921594 7.30600721510989e-10 mirMAP -0.105519293114893 1.58415058877614e-05 NA NA NA hsa-miR-1180-3p ETS1 1.13535217859875 1.17286173228245e-09 -0.888146453921594 7.30600721510989e-10 MirTarget -0.293265031973102 8.05459469251981e-16 NA NA NA hsa-miR-130b-5p ETS1 0.170599813152408 0.337611586432771 -0.888146453921594 7.30600721510989e-10 MirTarget -0.117830624648738 0.00350746127707538 NA NA NA hsa-miR-148b-5p ETS1 0.295777213389605 0.0255749859535438 -0.888146453921594 7.30600721510989e-10 MirTarget -0.14433424168597 0.00795478698949807 NA NA NA hsa-miR-16-1-3p ETS1 0.392360028038559 0.00112481918108198 -0.888146453921594 7.30600721510989e-10 MirTarget -0.14163124063757 0.0176332220270728 NA NA NA hsa-miR-186-5p ETS1 -0.060103391373687 0.535288717081205 -0.888146453921594 7.30600721510989e-10 mirMAP -0.15329403808341 0.0411464992332332 NA NA NA hsa-miR-193a-3p ETS1 -0.117675551589896 0.309391958208578 -0.888146453921594 7.30600721510989e-10 miRanda;miRNATAP -0.206450097116881 0.000921512501112203 NA NA NA hsa-miR-221-3p ETS1 1.12244756358612 3.48370308238012e-13 -0.888146453921594 7.30600721510989e-10 miRTarBase;miRNATAP -0.163620716574743 0.000282330030340872 21711453 To close the loop we demonstrate ETS-1 as a direct target of miR-222 but not miR-221 showing the novel option of their uncoupled functions melanoma hsa-miR-222-3p ETS1 1.08574156066353 1.76407192348131e-11 -0.888146453921594 7.30600721510989e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.114027687122358 0.00860678284178252 21711453 Constitutive activation of the ETS 1 miR 222 circuitry in metastatic melanoma; We demonstrate that the proto-oncogene ETS-1 involved in the pathogenesis of cancers of different origin is a transcriptional regulator of miR-222 by direct binding to its promoter region; Differently from 293FT cells or early stage melanomas where unphosphorylated ETS-1 represses miR-222 transcription in metastatic melanoma the constitutively Thr-38 phosphorylated fraction of ETS-1 induces miR-222; To close the loop we demonstrate ETS-1 as a direct target of miR-222 but not miR-221 showing the novel option of their uncoupled functions staging melanoma hsa-miR-30d-3p ETS1 -0.120562286038759 0.329549534782125 -0.888146453921594 7.30600721510989e-10 mirMAP -0.123711965263521 0.0344163749253352 NA NA NA hsa-miR-362-3p ETS1 0.814007335895913 2.00108618836568e-09 -0.888146453921594 7.30600721510989e-10 miRanda -0.181573270953595 0.000463194817826299 NA NA NA hsa-miR-365a-3p ETS1 0.164591326307714 0.15325084963213 -0.888146453921594 7.30600721510989e-10 MirTarget -0.267990900609134 1.68132949421869e-05 NA NA NA hsa-miR-421 ETS1 0.941856334694081 6.12167297054077e-08 -0.888146453921594 7.30600721510989e-10 miRanda;mirMAP;miRNATAP -0.204100092132273 4.23645182774089e-07 NA NA NA hsa-miR-455-5p ETS1 -0.270546034117157 0.0581320703577731 -0.888146453921594 7.30600721510989e-10 MirTarget;PITA;miRanda;miRNATAP -0.234313961624189 2.69025876931775e-06 NA NA NA hsa-miR-501-5p ETS1 1.15231083477882 2.98906150004088e-10 -0.888146453921594 7.30600721510989e-10 mirMAP -0.10302951257088 0.00734880104767461 NA NA NA hsa-miR-502-5p ETS1 0.892373335336396 1.7122694518919e-06 -0.888146453921594 7.30600721510989e-10 miRNATAP -0.110285767636931 0.00447567568456658 NA NA NA hsa-miR-532-3p ETS1 0.297601533259956 0.014632205884815 -0.888146453921594 7.30600721510989e-10 MirTarget;PITA;miRNATAP -0.287398076993315 8.8786296594351e-07 NA NA NA hsa-miR-590-5p ETS1 -0.103355559980404 0.310027295317092 -0.888146453921594 7.30600721510989e-10 miRanda -0.359124442253989 3.41545113201445e-07 NA NA NA hsa-miR-660-5p ETS1 0.989755850734071 5.69930767464937e-14 -0.888146453921594 7.30600721510989e-10 MirTarget -0.254076650434129 1.2827423637958e-06 NA NA NA hsa-miR-769-5p ETS1 0.219661452072771 0.0333425465750576 -0.888146453921594 7.30600721510989e-10 miRNATAP -0.213050530713541 0.00233319206600267 NA NA NA hsa-miR-940 ETS1 0.453020092551484 0.0177054921651997 -0.888146453921594 7.30600721510989e-10 MirTarget;miRNATAP -0.152992991185501 6.8236118996806e-05 NA NA NA hsa-miR-18a-5p ETS2 0.918028187958706 1.90229510425322e-05 -1.75880257972087 1.4083094059301e-32 miRNAWalker2_validate -0.206580300730223 5.77487879312806e-09 NA NA NA hsa-miR-221-3p ETS2 1.12244756358612 3.48370308238012e-13 -1.75880257972087 1.4083094059301e-32 miRNATAP -0.357161643234593 8.61994145380732e-14 NA NA NA hsa-miR-222-3p ETS2 1.08574156066353 1.76407192348131e-11 -1.75880257972087 1.4083094059301e-32 miRNATAP -0.317374648542082 6.19864720553015e-12 NA NA NA hsa-miR-30d-5p ETS2 0.718283816348023 2.47422074061352e-08 -1.75880257972087 1.4083094059301e-32 mirMAP -0.188621693080934 0.00161535558485025 NA NA NA hsa-miR-877-5p ETS2 1.35669625926821 1.43008125755656e-11 -1.75880257972087 1.4083094059301e-32 miRNAWalker2_validate -0.236694702246505 1.27914302479934e-09 NA NA NA hsa-miR-139-5p ETV7 -2.11299531796557 8.16407076415038e-28 -0.0813760495037565 0.76490396486266 miRanda -0.218063730345379 0.000641913106311154 NA NA NA hsa-miR-3607-3p EXTL3 -2.15518588554493 1.03390728226728e-23 0.602291383610503 5.83978727779557e-08 mirMAP -0.103592887797674 1.54521012959702e-05 NA NA NA hsa-miR-1269a EYA2 3.57543539205634 4.25369619949175e-08 -2.24669009462582 2.53906424525403e-11 MirTarget -0.119628598836343 5.98596260760561e-06 NA NA NA hsa-miR-424-5p EZH1 -2.62653257498508 2.38997974737991e-50 0.725552262954623 2.62851140068066e-20 MirTarget;miRNATAP -0.154637296702729 1.66763146213639e-15 NA NA NA hsa-miR-139-5p EZH2 -2.11299531796557 8.16407076415038e-28 2.56936752791081 3.12233537592977e-46 miRanda -0.594332946878018 6.29963320424694e-44 NA NA NA hsa-miR-144-3p EZH2 -2.97536914478815 6.00546047309683e-28 2.56936752791081 3.12233537592977e-46 miRNATAP -0.264373172345385 5.91588465496351e-16 23815091 miR 144 downregulation increases bladder cancer cell proliferation by targeting EZH2 and regulating Wnt signaling bladder cancer hsa-miR-139-5p FAIM -2.11299531796557 8.16407076415038e-28 0.589207851373054 1.02493249390092e-06 miRanda -0.150555346486063 1.11858915362056e-07 NA NA NA hsa-miR-139-5p FAM102B -2.11299531796557 8.16407076415038e-28 -0.162374897564143 0.256009972555516 miRanda -0.119775556498166 0.000352430592828182 NA NA NA hsa-miR-675-3p FAM111B -2.78074157259259 1.41541888062227e-14 3.15353527145587 2.06960384230063e-39 MirTarget -0.136826977311246 6.65182591104204e-05 NA NA NA hsa-miR-3607-3p FAM117B -2.15518588554493 1.03390728226728e-23 0.103695795405027 0.442637591978479 MirTarget -0.115439073706753 5.85199276806814e-05 NA NA NA hsa-miR-3607-3p FAM122B -2.15518588554493 1.03390728226728e-23 0.700049042471989 2.57159926016359e-12 MirTarget -0.131235285063949 1.20830848127476e-09 NA NA NA hsa-miR-424-5p FAM122B -2.62653257498508 2.38997974737991e-50 0.700049042471989 2.57159926016359e-12 MirTarget -0.132622201849155 8.36591793499446e-08 NA NA NA hsa-miR-33b-5p FAM129A -2.28852395459234 2.69046626645242e-22 0.12392999174645 0.476752975486638 mirMAP -0.1221615548243 0.000355171432213618 NA NA NA hsa-miR-199b-3p FAM133A -2.33226605401203 9.51887435273314e-18 1.83787122276161 0.00087266704058653 miRNATAP -0.351274866550157 0.000218358891217269 NA NA NA hsa-miR-424-5p FAM134A -2.62653257498508 2.38997974737991e-50 0.31241986271071 6.33121602143484e-06 MirTarget;miRNATAP -0.129156603047287 4.00069541887138e-15 NA NA NA hsa-miR-10b-5p FAM13A 2.86931593037303 6.97409423207806e-23 -2.57744428571964 2.57406538004678e-26 miRNAWalker2_validate -0.171357626301766 2.54126357320205e-05 NA NA NA hsa-miR-3607-3p FAM155B -2.15518588554493 1.03390728226728e-23 1.18777993849153 0.00400870110034955 miRNATAP -0.274256056332603 0.00198958422087638 NA NA NA hsa-miR-10b-5p FAM167A 2.86931593037303 6.97409423207806e-23 -1.07597904522454 0.00305476625411289 mirMAP -0.196130472635515 0.000649675911621562 NA NA NA hsa-miR-224-5p FAM46C 2.67175249172213 1.46995328399796e-18 -1.65510942063513 7.80605621031549e-14 MirTarget -0.147741800500687 2.19064793418058e-05 NA NA NA hsa-miR-144-3p FAM60A -2.97536914478815 6.00546047309683e-28 0.192304077099517 0.226575212179834 MirTarget;miRNATAP -0.100861172816188 0.000139724111266115 NA NA NA hsa-miR-139-5p FAM83D -2.11299531796557 8.16407076415038e-28 2.33803155229483 1.09911702307113e-30 miRanda -0.403180965751654 6.1623594830282e-16 NA NA NA hsa-miR-139-5p FANCA -2.11299531796557 8.16407076415038e-28 1.2099689861293 1.36777051245759e-15 miRanda -0.316020345315761 4.77603867102831e-19 NA NA NA hsa-miR-139-5p FANCB -2.11299531796557 8.16407076415038e-28 2.02653925630375 2.17352042502674e-21 miRanda -0.572455287368032 2.19900531239093e-31 NA NA NA hsa-miR-25-3p FASLG 0.633062563556379 3.68686354834328e-10 -0.789267794109529 0.000910923617828174 miRNATAP -0.409147266425705 0.000319496225971281 NA NA NA hsa-miR-424-5p FASN -2.62653257498508 2.38997974737991e-50 0.950044385482027 2.27190916019197e-06 MirTarget -0.246433856833846 5.43241175246387e-07 23599729 Tumor suppressive microRNA 424 inhibits osteosarcoma cell migration and invasion via targeting fatty acid synthase; The results showed that FASN is a promising target gene of miR-424; FASN may be a direct target of miR-424 as shown by the luciferase reporter assays; These findings suggested that miR-424 plays a key role in inhibiting OS cell migration and invasion through targeting FASN cell migration sarcoma hsa-miR-144-3p FBXL19 -2.97536914478815 6.00546047309683e-28 1.09129763767905 3.05430880690495e-25 miRNATAP -0.13135641192936 5.14866649141154e-13 NA NA NA hsa-miR-139-5p FBXO32 -2.11299531796557 8.16407076415038e-28 1.49973264070402 1.35888111194844e-11 miRanda -0.248867014578252 2.84390884190769e-06 NA NA NA hsa-miR-144-3p FBXO32 -2.97536914478815 6.00546047309683e-28 1.49973264070402 1.35888111194844e-11 miRNATAP -0.123870260990645 0.00112473386271035 NA NA NA hsa-miR-33b-5p FER -2.28852395459234 2.69046626645242e-22 0.687515996151434 1.81038736778444e-06 mirMAP -0.10152356346299 0.000394960810408952 NA NA NA hsa-miR-144-3p FGD6 -2.97536914478815 6.00546047309683e-28 0.314033910840616 0.0439181907931429 MirTarget -0.118007471803827 5.18856074720854e-06 NA NA NA hsa-miR-16-1-3p FGF1 0.392360028038559 0.00112481918108198 -0.678542882304208 0.00654328337233827 mirMAP -0.418480509125599 3.32517568843891e-05 NA NA NA hsa-miR-186-5p FGF1 -0.060103391373687 0.535288717081205 -0.678542882304208 0.00654328337233827 mirMAP -0.41367102247344 0.00114927327556726 NA NA NA hsa-miR-18a-5p FGF1 0.918028187958706 1.90229510425322e-05 -0.678542882304208 0.00654328337233827 MirTarget -0.257554404550762 3.95122313648269e-06 NA NA NA hsa-miR-193a-3p FGF1 -0.117675551589896 0.309391958208578 -0.678542882304208 0.00654328337233827 PITA -0.263712896327332 0.0131230572746261 NA NA NA hsa-miR-28-5p FGF1 -0.430964830599964 2.67367257252925e-06 -0.678542882304208 0.00654328337233827 miRanda -0.300844005713061 0.0239832343778685 NA NA NA hsa-miR-361-5p FGF1 0.233202959858696 0.00961572812255327 -0.678542882304208 0.00654328337233827 miRanda -0.510174670094289 0.000185533193035221 NA NA NA hsa-miR-532-3p FGF1 0.297601533259956 0.014632205884815 -0.678542882304208 0.00654328337233827 miRNATAP -0.242355716211253 0.0159768691352803 NA NA NA hsa-miR-550a-5p FGF1 0.156224023171823 0.282505553619229 -0.678542882304208 0.00654328337233827 MirTarget -0.374323243103714 7.86437510357121e-06 NA NA NA hsa-miR-576-5p FGF1 -0.377452008285847 0.00470735657343984 -0.678542882304208 0.00654328337233827 PITA;mirMAP -0.266396057997619 0.00356602502679197 NA NA NA hsa-miR-590-5p FGF1 -0.103355559980404 0.310027295317092 -0.678542882304208 0.00654328337233827 MirTarget;miRanda;miRNATAP -0.467961306585168 0.000104595555173684 NA NA NA hsa-let-7a-5p FGF11 -0.328069937201898 0.000464344093744051 0.213353925569267 0.274831508108713 TargetScan;mirMAP;miRNATAP -0.205257761608876 0.045024100259283 NA NA NA hsa-let-7g-5p FGF11 -0.461294133285527 2.17210114729901e-05 0.213353925569267 0.274831508108713 mirMAP;miRNATAP -0.222948986060156 0.0108825815373548 NA NA NA hsa-miR-193b-3p FGF11 -0.166697207281748 0.272022543069482 0.213353925569267 0.274831508108713 miRNAWalker2_validate -0.200531716988523 0.00140906192264391 NA NA NA hsa-miR-28-5p FGF11 -0.430964830599964 2.67367257252925e-06 0.213353925569267 0.274831508108713 miRanda -0.376056857807372 0.00027660131559535 NA NA NA hsa-miR-30c-1-3p FGF11 -1.39373825444537 6.39912952911454e-17 0.213353925569267 0.274831508108713 MirTarget -0.123393512882834 0.0269730575651704 NA NA NA hsa-miR-548b-3p FGF11 -0.0203576084717134 0.930819503166956 0.213353925569267 0.274831508108713 mirMAP -0.150043977025028 0.00025412409602433 NA NA NA hsa-miR-142-5p FGF12 -1.44575553250033 1.18797044680592e-13 1.12701565396445 0.000125070474588253 miRNATAP -0.162688840318932 0.0236663884216539 NA NA NA hsa-miR-17-5p FGF12 0.698861147045461 2.43854106455398e-05 1.12701565396445 0.000125070474588253 TargetScan -0.353312293407124 4.00239309386818e-05 NA NA NA hsa-miR-200b-3p FGF12 -1.29335788099229 0.000268623234305059 1.12701565396445 0.000125070474588253 TargetScan -0.167486025000735 2.91497216782912e-05 NA NA NA hsa-miR-33a-3p FGF12 -0.683025859637737 1.01106097756419e-05 1.12701565396445 0.000125070474588253 mirMAP -0.183612427920937 0.0480610556529538 NA NA NA hsa-miR-429 FGF12 -1.40262535827285 6.93982219171912e-05 1.12701565396445 0.000125070474588253 miRNATAP -0.176507119934699 1.51329896482206e-05 NA NA NA hsa-miR-455-5p FGF12 -0.270546034117157 0.0581320703577731 1.12701565396445 0.000125070474588253 miRanda -0.2955118739476 0.00352688948327299 NA NA NA hsa-miR-483-3p FGF12 -2.99328900859484 2.67538108509603e-07 1.12701565396445 0.000125070474588253 PITA -0.119968404362397 8.50806205124405e-07 NA NA NA hsa-miR-511-5p FGF12 -1.75067415533112 3.37801163573342e-23 1.12701565396445 0.000125070474588253 MirTarget -0.186644207276083 0.0159854311362721 NA NA NA hsa-miR-889-3p FGF12 -0.704721025765331 0.0139978010941786 1.12701565396445 0.000125070474588253 MirTarget -0.131935954446475 0.00860562658075859 NA NA NA hsa-miR-338-5p FGF13 -0.221898432884726 0.252390988727086 1.04387202836938 0.000243713997792116 PITA -0.173016374965949 0.017133155814658 NA NA NA hsa-miR-455-5p FGF13 -0.270546034117157 0.0581320703577731 1.04387202836938 0.000243713997792116 PITA;miRanda -0.315950161217624 0.00124978729248725 NA NA NA hsa-miR-618 FGF13 0.13539895350352 0.517145913114103 1.04387202836938 0.000243713997792116 PITA;miRNATAP -0.172748645688448 0.0127096032406027 NA NA NA hsa-miR-193a-5p FGF14 -0.472805720224262 1.24962968905481e-05 -0.650638914328184 0.0386566233872504 TargetScan -0.396389198365541 0.00514712574405294 NA NA NA hsa-miR-362-3p FGF14 0.814007335895913 2.00108618836568e-09 -0.650638914328184 0.0386566233872504 miRanda -0.296503371024151 0.00779105168383237 NA NA NA hsa-miR-421 FGF14 0.941856334694081 6.12167297054077e-08 -0.650638914328184 0.0386566233872504 miRanda -0.459990027128502 9.7647751856669e-08 NA NA NA hsa-miR-103a-3p FGF2 0.765568928457606 3.05497476509383e-12 -1.08625533231299 0.000324809942833161 miRNAWalker2_validate;MirTarget;miRNATAP -0.333696884446656 0.0118326533065286 NA NA NA hsa-miR-15b-3p FGF2 0.238105490431193 0.0997721500357416 -1.08625533231299 0.000324809942833161 mirMAP -0.499213807743807 9.41955107470528e-07 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-5p FGF2 0.230566941413564 0.0824765001857479 -1.08625533231299 0.000324809942833161 MirTarget;miRNATAP -0.306809751282981 0.00622064491645458 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-2-3p FGF2 -0.0336420826463706 0.805158952566973 -1.08625533231299 0.000324809942833161 mirMAP -0.422467965590387 0.000103679884556575 NA NA NA hsa-miR-181a-5p FGF2 0.250113435902954 0.0551933249319293 -1.08625533231299 0.000324809942833161 mirMAP -0.406045352280239 0.000358497143826792 NA NA NA hsa-miR-181b-5p FGF2 0.488256489401108 0.00105321129419701 -1.08625533231299 0.000324809942833161 mirMAP -0.523910277677257 9.1015168945214e-08 NA NA NA hsa-miR-19b-1-5p FGF2 -0.277804782598538 0.0783067794722916 -1.08625533231299 0.000324809942833161 mirMAP -0.529151998934904 1.16181517704286e-08 NA NA NA hsa-miR-200b-3p FGF2 -1.29335788099229 0.000268623234305059 -1.08625533231299 0.000324809942833161 mirMAP -0.168899172593471 4.11351056555817e-05 NA NA NA hsa-miR-200c-3p FGF2 -0.104675615392797 0.716957669484981 -1.08625533231299 0.000324809942833161 mirMAP -0.156084549253076 0.00233819769179705 NA NA NA hsa-miR-20a-3p FGF2 -0.318177901603857 0.0467885456739855 -1.08625533231299 0.000324809942833161 mirMAP -0.492065243098747 8.09310422865092e-08 NA NA NA hsa-miR-21-3p FGF2 -0.484219378716006 0.00299941098417659 -1.08625533231299 0.000324809942833161 mirMAP -0.240197113439825 0.00811114129230132 NA NA NA hsa-miR-21-5p FGF2 1.51084295924322 1.54551622173259e-34 -1.08625533231299 0.000324809942833161 mirMAP -0.443381765546842 5.91228766084995e-05 NA NA NA hsa-miR-215-5p FGF2 -0.981544773246509 3.14452272477156e-05 -1.08625533231299 0.000324809942833161 miRNAWalker2_validate -0.153448795618752 0.0138240489461602 NA NA NA hsa-miR-217 FGF2 1.05797297540381 0.0401026692682422 -1.08625533231299 0.000324809942833161 miRanda -0.127490520581258 7.38698652450206e-06 NA NA NA hsa-miR-222-3p FGF2 1.08574156066353 1.76407192348131e-11 -1.08625533231299 0.000324809942833161 mirMAP -0.206975558906397 0.0212088626227192 NA NA NA hsa-miR-330-3p FGF2 -0.332364259424489 0.0316051913061459 -1.08625533231299 0.000324809942833161 mirMAP -0.238733647850468 0.0151404054794887 NA NA NA hsa-miR-335-3p FGF2 -0.275199247483111 0.106629165248783 -1.08625533231299 0.000324809942833161 mirMAP -0.405107692314837 2.67658505476485e-06 NA NA NA hsa-miR-338-5p FGF2 -0.221898432884726 0.252390988727086 -1.08625533231299 0.000324809942833161 mirMAP -0.277477917380717 0.000298421894309671 NA NA NA hsa-miR-429 FGF2 -1.40262535827285 6.93982219171912e-05 -1.08625533231299 0.000324809942833161 mirMAP -0.192074793475977 4.45604159403906e-06 NA NA NA hsa-miR-452-5p FGF2 1.91544498799508 1.81995982853313e-14 -1.08625533231299 0.000324809942833161 mirMAP -0.254292038125162 7.84361502048493e-06 NA NA NA hsa-miR-589-3p FGF2 1.16846704028095 5.88525574424201e-11 -1.08625533231299 0.000324809942833161 mirMAP -0.346323302130209 2.68946343007257e-05 NA NA NA hsa-miR-590-5p FGF2 -0.103355559980404 0.310027295317092 -1.08625533231299 0.000324809942833161 miRanda;mirMAP -0.300649640419796 0.0415702477858108 NA NA NA hsa-miR-92a-3p FGF2 0.212391012518195 0.134292268089997 -1.08625533231299 0.000324809942833161 miRNAWalker2_validate -0.635934402042256 6.72536311164143e-10 NA NA NA hsa-miR-93-3p FGF2 0.402821129107592 0.00131324842735588 -1.08625533231299 0.000324809942833161 mirMAP -0.437085459323848 0.000209985380897254 NA NA NA hsa-miR-107 FGF7 0.241662461253461 0.0170788899505389 -0.653895802717462 0.00602323864930533 PITA;miRanda;miRNATAP -0.317347847907002 0.0061558373813029 NA NA NA hsa-miR-15a-5p FGF7 0.349521211668244 0.000770735998804736 -0.653895802717462 0.00602323864930533 miRTarBase;miRNATAP -0.366019587762154 0.00111409761072969 NA NA NA hsa-miR-15b-5p FGF7 0.230566941413564 0.0824765001857479 -0.653895802717462 0.00602323864930533 miRNATAP -0.392337856862938 7.12966084973613e-06 NA NA NA hsa-miR-16-1-3p FGF7 0.392360028038559 0.00112481918108198 -0.653895802717462 0.00602323864930533 mirMAP -0.272657830128381 0.00482946390365832 NA NA NA hsa-miR-16-2-3p FGF7 -0.0336420826463706 0.805158952566973 -0.653895802717462 0.00602323864930533 mirMAP -0.219047193513371 0.0107613787118728 NA NA NA hsa-miR-20a-5p FGF7 0.854326758727003 5.04256669663285e-07 -0.653895802717462 0.00602323864930533 miRNAWalker2_validate -0.341470101333498 3.32475785382172e-07 NA NA NA hsa-miR-30d-3p FGF7 -0.120562286038759 0.329549534782125 -0.653895802717462 0.00602323864930533 miRNATAP -0.243754787771991 0.010156368455823 NA NA NA hsa-miR-361-5p FGF7 0.233202959858696 0.00961572812255327 -0.653895802717462 0.00602323864930533 PITA;miRanda;miRNATAP -0.415294917437999 0.00146403039846296 NA NA NA hsa-miR-421 FGF7 0.941856334694081 6.12167297054077e-08 -0.653895802717462 0.00602323864930533 miRanda -0.230227109673969 0.000489381552238336 NA NA NA hsa-miR-452-5p FGF7 1.91544498799508 1.81995982853313e-14 -0.653895802717462 0.00602323864930533 mirMAP -0.102902434279624 0.0224141423460061 NA NA NA hsa-miR-455-3p FGF7 -1.3998033821095 5.72010709806871e-17 -0.653895802717462 0.00602323864930533 PITA;miRNATAP -0.173570787405519 0.00961793201913047 NA NA NA hsa-miR-590-3p FGF7 -0.473167498047808 1.76652934637227e-05 -0.653895802717462 0.00602323864930533 PITA;miRanda;mirMAP;miRNATAP -0.224658129152115 0.0334469179484906 NA NA NA hsa-miR-590-5p FGF7 -0.103355559980404 0.310027295317092 -0.653895802717462 0.00602323864930533 PITA;miRanda -0.57199782619933 5.74241805880331e-07 NA NA NA hsa-miR-616-5p FGF7 0.150569904638223 0.402836556304524 -0.653895802717462 0.00602323864930533 mirMAP -0.245435969787053 0.000149305105460564 NA NA NA hsa-miR-618 FGF7 0.13539895350352 0.517145913114103 -0.653895802717462 0.00602323864930533 mirMAP -0.227583154837617 7.48998921932753e-05 NA NA NA hsa-miR-106b-5p FGFR1 0.648901865047099 8.24870862047885e-09 -1.10351511026112 4.12675064572266e-07 mirMAP -0.284443073679231 0.0026248045594602 NA NA NA hsa-miR-15a-5p FGFR1 0.349521211668244 0.000770735998804736 -1.10351511026112 4.12675064572266e-07 miRNATAP -0.352840830794253 0.000677757595811867 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-17-5p FGFR1 0.698861147045461 2.43854106455398e-05 -1.10351511026112 4.12675064572266e-07 mirMAP -0.237393252177173 0.000224064428361276 NA NA NA hsa-miR-20a-5p FGFR1 0.854326758727003 5.04256669663285e-07 -1.10351511026112 4.12675064572266e-07 mirMAP -0.287282538249605 3.68706352846777e-06 NA NA NA hsa-miR-361-5p FGFR1 0.233202959858696 0.00961572812255327 -1.10351511026112 4.12675064572266e-07 miRanda -0.33530909970249 0.00556370932111968 NA NA NA hsa-miR-455-5p FGFR1 -0.270546034117157 0.0581320703577731 -1.10351511026112 4.12675064572266e-07 miRanda -0.249494978181263 0.000949827332507152 NA NA NA hsa-miR-532-5p FGFR1 1.02729546510601 9.93318913966636e-16 -1.10351511026112 4.12675064572266e-07 PITA -0.504576508830531 2.82854123723416e-10 NA NA NA hsa-miR-93-5p FGFR1 1.39518349670953 2.84167728726712e-25 -1.10351511026112 4.12675064572266e-07 mirMAP -0.326905735165641 1.37221347364255e-05 NA NA NA hsa-miR-107 FGFR2 0.241662461253461 0.0170788899505389 -2.28582334954307 1.14765468936708e-05 PITA;miRanda -0.690301810710163 0.0068857261082219 NA NA NA hsa-miR-146b-5p FGFR2 0.419719546795449 0.0457375823220155 -2.28582334954307 1.14765468936708e-05 miRanda -0.240513289535335 0.0492394721603946 NA NA NA hsa-miR-186-5p FGFR2 -0.060103391373687 0.535288717081205 -2.28582334954307 1.14765468936708e-05 miRNAWalker2_validate -0.622439160402499 0.0204360741476244 NA NA NA hsa-miR-100-5p FGFR3 -0.783576782126614 0.000219958772262677 0.189024805500786 0.340204942325551 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.269596147351536 1.27205852375091e-09 25344675;26604796;26018508;23778527 MicroRNA 100 regulates pancreatic cancer cells growth and sensitivity to chemotherapy through targeting FGFR3; The predicted target of miR-100 fibroblast growth factor receptor 3 FGFR3 was downregulated by siRNA to examine its effect on pancreatic cancer cells; Luciferase essay showed FGFR3 was direct target of miR-100; FGFR3 was significantly downregulated by overexpressing miR-100 in pancreatic cancer cells and knocking down FGFR3 by siRNA exerted similar effect as miR-100; Our study demonstrated that miR-100 played an important role in pancreatic cancer development possibly through targeting FGFR3;Overexpression of miR 100 inhibits cell proliferation migration and chemosensitivity in human glioblastoma through FGFR3; Expression of fibroblast growth factor receptor 3 FGFR3 the bioinformatically predicted target of miR-100 was examined by Western blot in glioblastoma; FGFR3 was directly regulated by miR-100 in glioblastoma; Ectopically overexpressing FGFR3 was able to ameliorate the anticancer effects of upregulation of miR-100 on glioblastoma growth migration and chemosensitivity; Overexpressing miR-100 had anticancer effects on glioblastoma likely through regulation of FGFR3;Overexpression of miR 100 inhibits growth of osteosarcoma through FGFR3; Here we reported significantly higher levels of fibroblast growth factor receptor 3 FGFR3 and significantly lower levels of miR-100 in the OS specimen compared to those in the paired normal bone tissues; Bioinformatics analysis and luciferase reporter assay suggest that miR-100 binds to the 3'UTR of FGFR3 mRNA to prevent its translation; Taken together our data demonstrate that miR-100 may inhibit the growth of OS through FGFR3;Hypoxia regulates FGFR3 expression via HIF 1α and miR 100 and contributes to cell survival in non muscle invasive bladder cancer; We have previously investigated the role of microRNAs in bladder cancer and have shown that FGFR3 is a target of miR-100; In this study we investigated the effects of hypoxia on miR-100 and FGFR3 expression and the link between miR-100 and FGFR3 in hypoxia; Bladder cancer cell lines were exposed to normoxic or hypoxic conditions and examined for the expression of FGFR3 by quantitative PCR qPCR and western blotting and miR-100 by qPCR; The effect of FGFR3 and miR-100 on cell viability in two-dimensional 2-D and three-dimensional 3-D was examined by transfecting siRNA or mimic-100 respectively; Increased FGFR3 was also in part dependent on miR-100 levels which decreased in hypoxia; Hypoxia in part via suppression of miR-100 induces FGFR3 expression in bladder cancer both of which have an important role in maintaining cell viability under conditions of stress ;;;poor survival pancreatic cancer;glioblastoma;sarcoma;bladder cancer hsa-miR-590-3p FGFR3 -0.473167498047808 1.76652934637227e-05 0.189024805500786 0.340204942325551 miRanda -0.178376084373127 0.0416868756939642 NA NA NA hsa-miR-99a-5p FGFR3 -1.51481656384839 3.93230057259529e-14 0.189024805500786 0.340204942325551 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.302096873169716 3.68370160731018e-11 23409016;24456664;23298836 Photofrin based photodynamic therapy and miR 99a transfection inhibited FGFR3 and PI3K/Akt signaling mechanisms to control growth of human glioblastoma In vitro and in vivo; Further photofrin based PDT followed by miR-99a transfection dramatically increased miR-99a expression and also increased apoptosis in glioblastoma cell cultures and drastically reduced tumor growth in athymic nude mice due to down regulation of fibroblast growth factor receptor 3 FGFR3 and PI3K/Akt signaling mechanisms leading to inhibition of cell proliferation and induction of molecular mechanisms of apoptosis;miR 99a promotes proliferation targeting FGFR3 in human epithelial ovarian cancer cells; Importantly fibroblast growth factor receptor 3 FGFR3 predicted to be one target gene of miR-99a using computational algorithms was higher in expression in EOC cells; Subsequently FGFR3 was proved to be direct target of miR-99a by dual luciferase assay; Furthermore overexpression of miR-99a dramatically suppressed expression level of FGFR3 at both mRNA and protein levels proving FGFR3 to be inversely correlated with miR-99a; Finally overexpression of miR-99a could significantly inhibit EOC cell proliferation in vitro by decreasing the expression of FGFR3 which also reduced the EOC cell growth after siRNA knockdown; Conclusively miR-99a expression was remarkably downregulated in serums tissues and cell and suppresses EOC cell proliferation by targeting FGFR3 suggesting miR-99a as a prospective prognosis marker and potential tumor suppressor for EOC therapeutics;The tumorigenic FGFR3 TACC3 gene fusion escapes miR 99a regulation in glioblastoma; The fusion caused by tandem duplication on 4p16.3 led to the loss of the 3'-UTR of FGFR3 blocking gene regulation of miR-99a and enhancing expression of the fusion gene ;worse prognosis; glioblastoma;ovarian cancer;glioblastoma hsa-miR-125a-3p FGFR4 -0.841683158494395 3.51202687176603e-05 0.491652034961419 0.019783553566567 miRanda -0.102327763515876 0.0468670155216684 NA NA NA hsa-miR-326 FGFR4 -1.881935132554 1.68087316863775e-21 0.491652034961419 0.019783553566567 miRanda;miRNATAP -0.275615867301029 2.26792389115162e-08 NA NA NA hsa-miR-491-5p FGFR4 -0.369122930844418 0.0154047757048929 0.491652034961419 0.019783553566567 miRanda -0.246783584450743 0.000288636596057226 NA NA NA hsa-miR-139-5p FIP1L1 -2.11299531796557 8.16407076415038e-28 0.297312272268257 8.44313297111126e-06 miRanda -0.103732676440991 1.75662119088927e-11 NA NA NA hsa-miR-106b-5p FLT1 0.648901865047099 8.24870862047885e-09 0.348253937407654 0.00775687550206773 MirTarget;miRNATAP -0.271203439813761 1.04770226280036e-06 NA NA NA hsa-miR-107 FLT1 0.241662461253461 0.0170788899505389 0.348253937407654 0.00775687550206773 miRanda -0.152136607021382 0.0167525451432682 NA NA NA hsa-miR-17-5p FLT1 0.698861147045461 2.43854106455398e-05 0.348253937407654 0.00775687550206773 MirTarget;TargetScan;miRNATAP -0.155467412569947 4.41226191642039e-05 NA NA NA hsa-miR-186-5p FLT1 -0.060103391373687 0.535288717081205 0.348253937407654 0.00775687550206773 mirMAP -0.163707818369349 0.0141986642107155 NA NA NA hsa-miR-19b-3p FLT1 0.601279551368824 0.00016685097085251 0.348253937407654 0.00775687550206773 MirTarget -0.106879008818879 0.00722041764726757 NA NA NA hsa-miR-20a-5p FLT1 0.854326758727003 5.04256669663285e-07 0.348253937407654 0.00775687550206773 MirTarget;miRNATAP -0.123502068793973 0.000848936793187574 NA NA NA hsa-miR-29a-5p FLT1 -0.113555908626946 0.349622266470788 0.348253937407654 0.00775687550206773 MirTarget -0.210145329786256 6.66000381524097e-05 NA NA NA hsa-miR-3200-3p FLT1 1.40312896232918 1.8232142177606e-07 0.348253937407654 0.00775687550206773 MirTarget -0.104775339523284 1.64518826352629e-05 NA NA NA hsa-miR-339-5p FLT1 0.280589919878422 0.0355660282647215 0.348253937407654 0.00775687550206773 miRanda -0.208449503114887 1.2161998602826e-05 NA NA NA hsa-miR-361-5p FLT1 0.233202959858696 0.00961572812255327 0.348253937407654 0.00775687550206773 miRanda -0.221523162209773 0.00197692560008583 NA NA NA hsa-miR-744-3p FLT1 -0.866026958622846 2.43034431433797e-08 0.348253937407654 0.00775687550206773 MirTarget -0.187874043185053 2.92559559268988e-06 NA NA NA hsa-miR-93-5p FLT1 1.39518349670953 2.84167728726712e-25 0.348253937407654 0.00775687550206773 MirTarget;miRNATAP -0.205648379982088 3.80614007626687e-06 NA NA NA hsa-miR-331-3p FLT4 -0.283974346994635 0.0373785411053202 -0.249744231852068 0.0849407092756091 miRNAWalker2_validate -0.118494252952587 0.0226564695202986 NA NA NA hsa-miR-374a-5p FLT4 0.016390363747302 0.869784217438621 -0.249744231852068 0.0849407092756091 mirMAP -0.256980012115421 0.000310181489933742 NA NA NA hsa-miR-374b-5p FLT4 -0.307538028546424 0.0030079617545972 -0.249744231852068 0.0849407092756091 mirMAP -0.195169979138197 0.00437956323796754 NA NA NA hsa-miR-3607-3p FLVCR1 -2.15518588554493 1.03390728226728e-23 2.21281107028163 8.50446492402864e-36 mirMAP;miRNATAP -0.22512498252217 3.77543072040373e-08 NA NA NA hsa-miR-224-5p FOSB 2.67175249172213 1.46995328399796e-18 -4.4314402700738 1.6911782147835e-35 miRNAWalker2_validate -0.355288592218668 1.37276322795451e-09 NA NA NA hsa-miR-199a-3p FOXA2 -2.3279328685682 1.04468066198593e-17 -0.38624907420399 0.0461249144404801 PITA -0.166783302519726 4.15903716073793e-07 NA NA NA hsa-miR-199b-3p FOXA2 -2.33226605401203 9.51887435273314e-18 -0.38624907420399 0.0461249144404801 PITA -0.166529560341423 4.25148245532811e-07 NA NA NA hsa-miR-3607-3p FOXF2 -2.15518588554493 1.03390728226728e-23 1.42606844181825 1.02893636282949e-06 miRNATAP -0.31347448567967 5.76999285090051e-07 NA NA NA hsa-miR-3607-3p FOXK1 -2.15518588554493 1.03390728226728e-23 1.204250755958 4.1435634806038e-25 miRNATAP -0.190768660443257 1.2085564141297e-13 NA NA NA hsa-miR-183-5p FOXO1 2.33444328833177 1.52188109365421e-10 -1.85047773748744 1.95333497559347e-31 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.169848804126297 4.22098120535378e-15 25813403;25983004 Knockdown of CTNNB1 also showed concordant down-regulations of miR-183 -96 and -182 and the re-expression of FOXO1;MiR 183 promotes growth of non small cell lung cancer cells through FoxO1 inhibition; Here we analyzed the regulation of FoxO1 by miR-183 in vitro using luciferase-reporter assay; Moreover miR-183 bound to FoxO1 mRNA to prevent its translation through its 3'untranslated region UTR; Furthermore administration of miR-183 suppressed FoxO1 levels in NSCLC resulting in a significant increase in NSCLC growth in vitro and in vivo while administration of antisense of miR-183 significantly increased FoxO1 levels in NSCLC resulting in a significant decrease in NSCLC growth ; liver cancer;lung squamous cell cancer hsa-miR-142-3p FOXO4 -1.4243101967815 1.92609481097765e-14 0.074724340674158 0.458502190612256 MirTarget;miRanda;miRNATAP -0.117367367130642 3.34068828445685e-06 NA NA NA hsa-miR-193a-3p FOXO4 -0.117675551589896 0.309391958208578 0.074724340674158 0.458502190612256 miRanda;miRNATAP -0.109765941004955 0.0100243918879802 NA NA NA hsa-miR-23a-3p FOXO4 -0.178875974460574 0.135978273540604 0.074724340674158 0.458502190612256 miRNATAP -0.123021598894151 0.0027046153798015 NA NA NA hsa-miR-339-5p FOXO4 0.280589919878422 0.0355660282647215 0.074724340674158 0.458502190612256 miRanda -0.129843670316144 0.000398174461329956 NA NA NA hsa-miR-484 FOXO4 0.0857240033709656 0.453982056282229 0.074724340674158 0.458502190612256 miRNATAP -0.187775379057745 1.15005670153111e-05 NA NA NA hsa-miR-3607-3p FSTL4 -2.15518588554493 1.03390728226728e-23 3.14060414756178 7.65786604995946e-16 miRNATAP -0.328774812308615 0.000139694730564383 NA NA NA hsa-miR-139-5p FSTL5 -2.11299531796557 8.16407076415038e-28 1.26790282915165 0.0138616495297151 miRanda -0.400296314381749 0.000985463312713195 NA NA NA hsa-miR-139-5p FUCA2 -2.11299531796557 8.16407076415038e-28 0.0869182957071164 0.416122429650749 miRanda -0.107229300600711 1.70113562229149e-05 NA NA NA hsa-miR-139-5p FUNDC1 -2.11299531796557 8.16407076415038e-28 0.345138622717543 5.94079176138208e-05 miRanda -0.161791420096626 1.6303213911555e-16 NA NA NA hsa-miR-10b-3p FUT4 2.77189254628215 2.26687582932628e-20 -0.446193249796337 0.0576043872013691 mirMAP -0.142428046213587 0.000280185277177179 NA NA NA hsa-miR-139-5p FUT4 -2.11299531796557 8.16407076415038e-28 -0.446193249796337 0.0576043872013691 mirMAP -0.172539660430133 0.00182308338291842 NA NA NA hsa-miR-10b-5p FUT6 2.86931593037303 6.97409423207806e-23 -1.49338381588791 3.36389591198156e-05 miRNAWalker2_validate -0.246389619627062 1.57581416472923e-05 NA NA NA hsa-miR-139-5p FZD6 -2.11299531796557 8.16407076415038e-28 0.589500198001939 0.00374127878510925 miRanda -0.171390807110702 0.00034847427750895 NA NA NA hsa-miR-424-5p G6PD -2.62653257498508 2.38997974737991e-50 1.94792702592171 1.26584087073773e-18 MirTarget -0.307081050847098 3.6044737071096e-08 NA NA NA hsa-miR-132-3p GAB1 0.323796239695997 0.00272093067935091 -0.316010954422049 0.00456197149339329 mirMAP -0.156184858478685 0.00198393470110477 NA NA NA hsa-miR-140-3p GAB1 0.546012239205329 4.84578261098777e-11 -0.316010954422049 0.00456197149339329 miRNATAP -0.214865035775059 0.000916938646369548 NA NA NA hsa-miR-16-1-3p GAB1 0.392360028038559 0.00112481918108198 -0.316010954422049 0.00456197149339329 mirMAP -0.11463088025181 0.0112507308142438 NA NA NA hsa-miR-17-5p GAB1 0.698861147045461 2.43854106455398e-05 -0.316010954422049 0.00456197149339329 MirTarget;TargetScan;miRNATAP -0.112097638373219 0.000562993319030765 NA NA NA hsa-miR-18a-5p GAB1 0.918028187958706 1.90229510425322e-05 -0.316010954422049 0.00456197149339329 MirTarget;miRNATAP -0.127326299597646 2.82730441276393e-07 NA NA NA hsa-miR-221-3p GAB1 1.12244756358612 3.48370308238012e-13 -0.316010954422049 0.00456197149339329 MirTarget;miRNATAP -0.141495019686334 3.2987590560242e-05 NA NA NA hsa-miR-222-3p GAB1 1.08574156066353 1.76407192348131e-11 -0.316010954422049 0.00456197149339329 MirTarget;miRNATAP -0.113511940450049 0.000539576846072762 NA NA NA hsa-miR-29b-3p GAB1 -0.348885528720517 0.0121441341291285 -0.316010954422049 0.00456197149339329 MirTarget -0.17642835277984 5.54484596942804e-06 NA NA NA hsa-miR-30d-3p GAB1 -0.120562286038759 0.329549534782125 -0.316010954422049 0.00456197149339329 mirMAP -0.14064525459027 0.00145953116791166 NA NA NA hsa-miR-34a-5p GAB1 1.03694231790865 5.74864019540594e-14 -0.316010954422049 0.00456197149339329 MirTarget -0.104287091677839 0.00647406484540799 NA NA NA hsa-miR-93-5p GAB1 1.39518349670953 2.84167728726712e-25 -0.316010954422049 0.00456197149339329 MirTarget;miRNATAP -0.130220299358394 0.00063327362729906 NA NA NA hsa-miR-148a-5p GAB2 -0.767626696027761 1.08359477494797e-06 0.582469424043986 4.14162511103667e-06 mirMAP -0.150112192167145 0.000116928574414138 NA NA NA hsa-miR-139-5p GABRA3 -2.11299531796557 8.16407076415038e-28 1.22788487071073 0.00166295951190448 miRanda -0.471143216143728 2.55469513320343e-07 NA NA NA hsa-miR-139-5p GALNT10 -2.11299531796557 8.16407076415038e-28 0.831350337705815 6.36030803570338e-11 miRanda -0.150395615779955 7.18236184720784e-07 NA NA NA hsa-miR-33b-5p GALNT10 -2.28852395459234 2.69046626645242e-22 0.831350337705815 6.36030803570338e-11 mirMAP -0.127448011189325 5.24465645406696e-07 NA NA NA hsa-miR-10b-5p GATA6 2.86931593037303 6.97409423207806e-23 -1.09329244365753 9.73202176150752e-11 miRNATAP -0.143021786205506 1.16225950761351e-07 NA NA NA hsa-miR-183-5p GCK 2.33444328833177 1.52188109365421e-10 -2.41523807209634 3.53030331726835e-05 mirMAP -0.192990445877687 0.0121052374668403 NA NA NA hsa-miR-139-5p GDF10 -2.11299531796557 8.16407076415038e-28 -0.107862925299458 0.794457781674648 MirTarget;PITA;miRanda;miRNATAP -0.258947196031913 0.00790854449185403 NA NA NA hsa-miR-139-5p GDPD1 -2.11299531796557 8.16407076415038e-28 1.18034735605724 1.12158927383629e-07 miRanda -0.304665616852154 6.08973773171489e-09 NA NA NA hsa-miR-424-5p GGA3 -2.62653257498508 2.38997974737991e-50 0.711679336404982 1.46861146142528e-21 MirTarget;miRNATAP -0.16573365210859 1.28119553807368e-19 NA NA NA hsa-miR-3607-3p GIGYF1 -2.15518588554493 1.03390728226728e-23 0.704244312848552 1.05052404549896e-17 MirTarget;miRNATAP -0.105715819062838 4.2149809842749e-09 NA NA NA hsa-miR-139-5p GINS1 -2.11299531796557 8.16407076415038e-28 2.57427144702613 8.73668271765131e-32 miRanda -0.700882164290473 2.73928001508044e-44 NA NA NA hsa-miR-139-5p GLDN -2.11299531796557 8.16407076415038e-28 1.85654071848598 4.54699264502673e-06 miRanda -0.676081219529125 6.48165282719607e-13 NA NA NA hsa-miR-10b-3p GLI2 2.77189254628215 2.26687582932628e-20 -1.14224882795575 0.000293659575288629 MirTarget -0.281899035840983 7.67842644714296e-08 NA NA NA hsa-miR-183-5p GLUL 2.33444328833177 1.52188109365421e-10 0.444046234271983 0.126185814713881 miRNAWalker2_validate;MirTarget -0.29066446620348 2.18154745576595e-15 NA NA NA hsa-miR-199a-3p GLYCTK -2.3279328685682 1.04468066198593e-17 -1.01640934546018 1.04866824354547e-07 mirMAP -0.120590735558553 0.000285021173591997 NA NA NA hsa-miR-199b-3p GLYCTK -2.33226605401203 9.51887435273314e-18 -1.01640934546018 1.04866824354547e-07 mirMAP -0.120198551057168 0.000295513443312588 NA NA NA hsa-miR-139-5p GNAL -2.11299531796557 8.16407076415038e-28 1.33283669629593 1.09261153741281e-06 miRanda -0.284522812917373 1.13471623336258e-05 NA NA NA hsa-miR-455-5p GNB1 -0.270546034117157 0.0581320703577731 0.0958557110185971 0.13435411812339 miRanda -0.105145596215111 1.02847761734852e-06 NA NA NA hsa-miR-3607-3p GNB1L -2.15518588554493 1.03390728226728e-23 0.972387895486426 1.58066300637692e-14 mirMAP -0.139916582875488 4.43768469210058e-07 NA NA NA hsa-miR-424-5p GNB1L -2.62653257498508 2.38997974737991e-50 0.972387895486426 1.58066300637692e-14 mirMAP -0.217993421579964 2.70994096062615e-12 NA NA NA hsa-miR-23b-3p GNB4 -0.530561587109023 5.43807206823652e-07 -0.928192910776987 2.12212917190083e-10 mirMAP -0.212892947304196 0.00183143660701724 NA NA NA hsa-miR-33a-3p GNB4 -0.683025859637737 1.01106097756419e-05 -0.928192910776987 2.12212917190083e-10 MirTarget -0.176715402998075 0.000146769007869337 NA NA NA hsa-miR-361-5p GNB4 0.233202959858696 0.00961572812255327 -0.928192910776987 2.12212917190083e-10 miRanda;miRNATAP -0.317825495404 9.33942049722369e-05 NA NA NA hsa-miR-616-5p GNB4 0.150569904638223 0.402836556304524 -0.928192910776987 2.12212917190083e-10 MirTarget -0.222542753601043 2.78176277489519e-08 NA NA NA hsa-miR-93-5p GNB4 1.39518349670953 2.84167728726712e-25 -0.928192910776987 2.12212917190083e-10 miRNAWalker2_validate -0.301938140081084 1.91212863286627e-09 NA NA NA hsa-miR-342-3p GNB5 -0.319677314984262 0.0449813878317147 0.426876502902471 0.00235496717551496 miRanda -0.105374562570879 0.0145417287903282 NA NA NA hsa-miR-361-5p GNB5 0.233202959858696 0.00961572812255327 0.426876502902471 0.00235496717551496 miRanda -0.262212101044684 0.000646181117085778 NA NA NA hsa-miR-320a GNG11 0.325285936317332 0.0221415065838824 -0.267065483679 0.0421198237385163 miRanda -0.103843922028116 0.0215333766612867 NA NA NA hsa-miR-107 GNG12 0.241662461253461 0.0170788899505389 -0.749024820971969 9.12787292602269e-08 miRanda -0.352109955711477 2.43072591256035e-07 NA NA NA hsa-miR-338-3p GNG12 0.543135607704581 0.00461167747143826 -0.749024820971969 9.12787292602269e-08 miRanda -0.148937421383934 3.25125790279736e-05 NA NA NA hsa-miR-423-5p GNG12 0.698807775906485 1.02195196334612e-11 -0.749024820971969 9.12787292602269e-08 miRNAWalker2_validate -0.289354784524697 1.13499456269689e-05 NA NA NA hsa-miR-455-5p GNG12 -0.270546034117157 0.0581320703577731 -0.749024820971969 9.12787292602269e-08 miRanda -0.226520595073207 2.68617949312973e-06 NA NA NA hsa-miR-23b-3p GNG2 -0.530561587109023 5.43807206823652e-07 -0.850794425511732 6.29859635775606e-10 miRNATAP -0.213834398091893 0.000864226876006079 NA NA NA hsa-miR-30d-3p GNG2 -0.120562286038759 0.329549534782125 -0.850794425511732 6.29859635775606e-10 mirMAP -0.121035591809031 0.0300998362618287 NA NA NA hsa-miR-455-5p GNG2 -0.270546034117157 0.0581320703577731 -0.850794425511732 6.29859635775606e-10 miRanda -0.229407106619483 1.4480956300012e-06 NA NA NA hsa-miR-618 GNG2 0.13539895350352 0.517145913114103 -0.850794425511732 6.29859635775606e-10 PITA;miRNATAP -0.159357772778274 2.17753784300249e-06 NA NA NA hsa-miR-193b-3p GNG4 -0.166697207281748 0.272022543069482 3.13065787191005 3.93511130749918e-08 mirMAP -0.727189516843406 9.21560908852491e-05 NA NA NA hsa-miR-199a-3p GNG4 -2.3279328685682 1.04468066198593e-17 3.13065787191005 3.93511130749918e-08 mirMAP -0.374794502377641 0.000158579044743277 NA NA NA hsa-miR-199b-3p GNG4 -2.33226605401203 9.51887435273314e-18 3.13065787191005 3.93511130749918e-08 mirMAP -0.375110385417779 0.000154799510229959 NA NA NA hsa-miR-23b-3p GNG4 -0.530561587109023 5.43807206823652e-07 3.13065787191005 3.93511130749918e-08 mirMAP -0.973422557249314 0.000234898535428262 NA NA NA hsa-miR-326 GNG4 -1.881935132554 1.68087316863775e-21 3.13065787191005 3.93511130749918e-08 mirMAP -0.493070991901794 0.000310359418335552 NA NA NA hsa-miR-542-3p GNG4 -1.31351015149842 3.64642423288576e-22 3.13065787191005 3.93511130749918e-08 mirMAP -0.569049863655344 0.00406660259271405 NA NA NA hsa-let-7a-5p GNG5 -0.328069937201898 0.000464344093744051 0.00889434951085377 0.914434057152244 MirTarget;TargetScan;miRNATAP -0.133605931047702 0.00189613241874912 NA NA NA hsa-let-7g-5p GNG5 -0.461294133285527 2.17210114729901e-05 0.00889434951085377 0.914434057152244 MirTarget;miRNATAP -0.124150824567995 0.000740157885149412 NA NA NA hsa-miR-100-5p GNG5 -0.783576782126614 0.000219958772262677 0.00889434951085377 0.914434057152244 miRNAWalker2_validate -0.111679571746108 1.44073402187179e-09 NA NA NA hsa-miR-141-3p GNG7 -0.354316381352484 0.256996894288799 -0.344922469297116 0.0809202837414247 MirTarget;TargetScan;miRNATAP -0.142045092870118 3.59031496857192e-06 NA NA NA hsa-miR-181a-2-3p GNG7 -0.232005557505191 0.236404981276858 -0.344922469297116 0.0809202837414247 mirMAP -0.167242874656 0.00065765335078702 NA NA NA hsa-miR-185-3p GNG7 -0.270845540360709 0.0853959272273836 -0.344922469297116 0.0809202837414247 mirMAP -0.235740423921735 0.00011242527300071 NA NA NA hsa-miR-18a-5p GNG7 0.918028187958706 1.90229510425322e-05 -0.344922469297116 0.0809202837414247 mirMAP -0.25413478130125 6.30826943853662e-09 NA NA NA hsa-miR-1976 GNG7 -0.431472440543166 0.00324575010550946 -0.344922469297116 0.0809202837414247 mirMAP -0.14652164362347 0.0259303838223497 NA NA NA hsa-miR-23a-3p GNG7 -0.178875974460574 0.135978273540604 -0.344922469297116 0.0809202837414247 mirMAP -0.177962783225255 0.0279247090003393 NA NA NA hsa-miR-3127-5p GNG7 0.837385386388614 2.06679743975142e-07 -0.344922469297116 0.0809202837414247 mirMAP -0.280943833100497 1.58985906059257e-06 NA NA NA hsa-miR-330-5p GNG7 0.442231058604099 0.0053308560843808 -0.344922469297116 0.0809202837414247 mirMAP -0.266239080017072 9.77779269561468e-06 NA NA NA hsa-miR-338-5p GNG7 -0.221898432884726 0.252390988727086 -0.344922469297116 0.0809202837414247 PITA;miRNATAP -0.178234078899153 0.000350792048639832 NA NA NA hsa-miR-3615 GNG7 0.437674495807452 0.000852818785910106 -0.344922469297116 0.0809202837414247 mirMAP -0.326159279457622 7.52320602896003e-06 NA NA NA hsa-miR-3913-5p GNG7 0.247553671224336 0.062795011081188 -0.344922469297116 0.0809202837414247 mirMAP -0.413758257686458 8.23372292003807e-09 NA NA NA hsa-miR-500a-3p GNG7 1.18913245435489 1.59516890341346e-16 -0.344922469297116 0.0809202837414247 mirMAP -0.163323714205459 0.011394524113313 NA NA NA hsa-miR-590-3p GNG7 -0.473167498047808 1.76652934637227e-05 -0.344922469297116 0.0809202837414247 PITA;miRanda;mirMAP -0.337357170032764 0.000103056255264498 NA NA NA hsa-miR-616-5p GNG7 0.150569904638223 0.402836556304524 -0.344922469297116 0.0809202837414247 MirTarget -0.214703356428535 6.00489016444381e-05 NA NA NA hsa-miR-671-5p GNG7 0.843645373345787 3.92794196273313e-08 -0.344922469297116 0.0809202837414247 mirMAP -0.332238265928659 5.5235653910779e-08 NA NA NA hsa-miR-766-3p GNG7 0.199979324759329 0.257230732626744 -0.344922469297116 0.0809202837414247 MirTarget -0.242495661121196 7.90602635709586e-06 NA NA NA hsa-miR-940 GNG7 0.453020092551484 0.0177054921651997 -0.344922469297116 0.0809202837414247 MirTarget -0.292037147028017 1.09815456267002e-08 NA NA NA hsa-miR-219a-1-3p GNGT2 -0.065863458123071 0.645858701126434 -0.701598672056643 5.82578274783021e-05 MirTarget -0.260826527717683 1.27876547872272e-05 NA NA NA hsa-miR-139-5p GOLGA6L9 -2.11299531796557 8.16407076415038e-28 1.08099271915988 1.80765508375942e-15 miRanda -0.233600795193513 4.63614048434342e-13 NA NA NA hsa-miR-139-5p GOLGA8A -2.11299531796557 8.16407076415038e-28 1.65070395716262 1.06380851127381e-16 miRanda -0.142844143177881 0.00336077427445539 NA NA NA hsa-miR-139-5p GOLGA8B -2.11299531796557 8.16407076415038e-28 1.75679039706065 1.32546952928519e-21 miRanda -0.18931951237435 3.03363717737153e-05 NA NA NA hsa-miR-139-5p GON4L -2.11299531796557 8.16407076415038e-28 0.653062421759548 6.52447977507908e-13 miRanda -0.108138857124131 6.50897937628477e-07 NA NA NA hsa-miR-183-5p GPAM 2.33444328833177 1.52188109365421e-10 -0.472844151955403 0.0637965177079971 MirTarget -0.21133364548813 9.20014731906037e-11 NA NA NA hsa-miR-139-5p GPATCH2 -2.11299531796557 8.16407076415038e-28 0.460255561772317 5.26548841067473e-07 miRanda -0.110855676248726 2.82998007576432e-07 NA NA NA hsa-miR-139-5p GPD1L -2.11299531796557 8.16407076415038e-28 0.459518744777133 0.00831621590013787 MirTarget;PITA;miRanda;miRNATAP -0.233839049792638 7.71068353898303e-09 NA NA NA hsa-miR-3607-3p GPD1L -2.15518588554493 1.03390728226728e-23 0.459518744777133 0.00831621590013787 MirTarget;miRNATAP -0.134762983719773 0.000299787514467999 NA NA NA hsa-miR-139-5p GPD2 -2.11299531796557 8.16407076415038e-28 0.404567318088859 0.000374344403235026 miRanda -0.237151138609026 2.76632420552627e-20 NA NA NA hsa-miR-139-5p GPR19 -2.11299531796557 8.16407076415038e-28 2.26877210340845 1.58451791616503e-23 miRanda -0.537399288764309 1.20578857868107e-23 NA NA NA hsa-miR-139-5p GPR85 -2.11299531796557 8.16407076415038e-28 -0.512745687174905 0.0113337656979268 mirMAP -0.123547495104376 0.00981198472746961 NA NA NA hsa-miR-10b-3p GPRIN2 2.77189254628215 2.26687582932628e-20 -3.25654701349871 4.8807952090335e-15 mirMAP -0.568303042236119 3.16076406839338e-16 NA NA NA hsa-miR-139-5p GPSM2 -2.11299531796557 8.16407076415038e-28 1.45389191030237 4.5650425831655e-20 miRanda -0.417973101150436 1.70859636198877e-30 NA NA NA hsa-miR-10b-3p GREM1 2.77189254628215 2.26687582932628e-20 -0.0577956254982771 0.888064615887716 MirTarget -0.215824065622198 0.00163399492159191 NA NA NA hsa-miR-10b-3p GREM2 2.77189254628215 2.26687582932628e-20 -3.6542600937751 6.32290251963313e-12 mirMAP;miRNATAP -0.288193424477712 0.00158752772943192 NA NA NA hsa-miR-183-5p GREM2 2.33444328833177 1.52188109365421e-10 -3.6542600937751 6.32290251963313e-12 miRNATAP -0.412477288127133 4.01379975762556e-09 NA NA NA hsa-miR-144-3p GRIK4 -2.97536914478815 6.00546047309683e-28 1.21698116585755 0.000489990948437745 MirTarget -0.304821837852754 1.5650758079736e-07 NA NA NA hsa-miR-101-5p GRIN2A -1.0634649894055 4.39116719827902e-16 0.997469291842062 0.0157432290597052 mirMAP -0.981940818305768 1.71767881285298e-11 NA NA NA hsa-miR-107 GRIN2A 0.241662461253461 0.0170788899505389 0.997469291842062 0.0157432290597052 miRanda -0.450247020728363 0.0252144152514506 NA NA NA hsa-miR-125b-5p GRIN2A -1.35767721102906 1.16564617395164e-18 0.997469291842062 0.0157432290597052 miRNAWalker2_validate;miRTarBase -0.458782355450757 0.000250155000655396 NA NA NA hsa-miR-126-5p GRIN2A -0.428561469405594 6.6035585844222e-05 0.997469291842062 0.0157432290597052 mirMAP -0.446974910349874 0.0175859854469916 NA NA NA hsa-miR-1271-5p GRIN2A -1.00001044718608 1.30308965099272e-09 0.997469291842062 0.0157432290597052 mirMAP -0.245469437835009 0.0431929270020359 NA NA NA hsa-miR-130b-5p GRIN2A 0.170599813152408 0.337611586432771 0.997469291842062 0.0157432290597052 mirMAP -0.668951599500979 2.17349784507966e-09 NA NA NA hsa-miR-139-5p GRIN2A -2.11299531796557 8.16407076415038e-28 0.997469291842062 0.0157432290597052 PITA -0.384540361756604 7.49315780234321e-05 NA NA NA hsa-miR-186-5p GRIN2A -0.060103391373687 0.535288717081205 0.997469291842062 0.0157432290597052 mirMAP -0.731330584872555 0.000506388419481316 NA NA NA hsa-miR-193a-5p GRIN2A -0.472805720224262 1.24962968905481e-05 0.997469291842062 0.0157432290597052 mirMAP -0.535016506777859 0.00405237278267554 NA NA NA hsa-miR-29a-5p GRIN2A -0.113555908626946 0.349622266470788 0.997469291842062 0.0157432290597052 mirMAP -0.779193054096883 2.67829839166251e-06 NA NA NA hsa-miR-32-3p GRIN2A 0.219109440121582 0.207217051619543 0.997469291842062 0.0157432290597052 mirMAP -0.31189885450612 0.00951961130868574 NA NA NA hsa-miR-33a-3p GRIN2A -0.683025859637737 1.01106097756419e-05 0.997469291842062 0.0157432290597052 mirMAP -0.594234756455291 3.80741189867432e-06 NA NA NA hsa-miR-582-5p GRIN2A -0.680189083316822 0.00103755166534107 0.997469291842062 0.0157432290597052 mirMAP -0.271376602977608 0.00525362641197759 NA NA NA hsa-miR-590-3p GRIN2A -0.473167498047808 1.76652934637227e-05 0.997469291842062 0.0157432290597052 miRanda;mirMAP -0.469755528278551 0.0102358959959846 NA NA NA hsa-miR-590-5p GRIN2A -0.103355559980404 0.310027295317092 0.997469291842062 0.0157432290597052 miRanda -0.711907277300972 0.000367381352985748 NA NA NA hsa-miR-7-1-3p GRIN2A -0.569105143287799 1.85297665041424e-05 0.997469291842062 0.0157432290597052 mirMAP -0.49014081739647 0.00115683296694079 NA NA NA hsa-miR-139-5p GTF2H2B -2.11299531796557 8.16407076415038e-28 0.24951434585312 0.386030692736906 miRanda -0.235846150791464 0.00048404605599665 NA NA NA hsa-miR-424-5p GTF3C5 -2.62653257498508 2.38997974737991e-50 0.419125796162832 1.00577542504161e-06 MirTarget -0.153898383757588 6.55282834918659e-14 NA NA NA hsa-miR-139-5p GTSE1 -2.11299531796557 8.16407076415038e-28 3.36484553481514 9.01399399431822e-38 miRanda -0.852470510147384 1.24510618616795e-44 NA NA NA hsa-miR-139-5p GULP1 -2.11299531796557 8.16407076415038e-28 -0.40117278239696 0.328073008560451 MirTarget;miRanda -0.308188839052977 0.00139922810216736 NA NA NA hsa-miR-144-3p HAPLN1 -2.97536914478815 6.00546047309683e-28 1.33038232891219 0.000123661512782167 miRNATAP -0.117489110176179 0.044983032131302 NA NA NA hsa-miR-139-5p HARS2 -2.11299531796557 8.16407076415038e-28 0.569422522197446 3.41173784588814e-15 MirTarget;miRanda;miRNATAP -0.104181914489679 1.5206320051144e-09 NA NA NA hsa-miR-424-5p HARS2 -2.62653257498508 2.38997974737991e-50 0.569422522197446 3.41173784588814e-15 MirTarget -0.152570216219254 2.54800206043346e-18 NA NA NA hsa-miR-139-5p HAUS8 -2.11299531796557 8.16407076415038e-28 0.305327108288584 0.00219158452346835 miRanda -0.12308318607369 1.1665640066629e-07 NA NA NA hsa-miR-139-5p HCP5 -2.11299531796557 8.16407076415038e-28 1.59312857714195 2.4458002641921e-09 miRanda -0.285369434492499 9.2147587069639e-10 NA NA NA hsa-miR-33b-5p HDAC4 -2.28852395459234 2.69046626645242e-22 1.00691818288109 6.96034330486747e-18 mirMAP -0.154242806884597 5.38272293260378e-11 NA NA NA hsa-miR-3607-3p HDAC4 -2.15518588554493 1.03390728226728e-23 1.00691818288109 6.96034330486747e-18 mirMAP -0.162252137955414 2.24028399959644e-10 NA NA NA hsa-miR-424-5p HDGF -2.62653257498508 2.38997974737991e-50 0.144857819793126 0.0532740935303875 miRNATAP -0.102902011941702 9.9884479719646e-09 NA NA NA hsa-miR-139-5p HECTD2 -2.11299531796557 8.16407076415038e-28 0.52661577542202 0.000257602291625105 miRanda -0.114178125358855 0.000802777282767368 NA NA NA hsa-miR-3607-3p HELLS -2.15518588554493 1.03390728226728e-23 2.62327787224869 1.35869467447747e-28 mirMAP -0.346324840916352 7.90375201669512e-11 NA NA NA hsa-miR-139-5p HERC2P2 -2.11299531796557 8.16407076415038e-28 1.30606414107212 6.53734456861824e-17 miRanda -0.136077374103285 0.000365050291975761 NA NA NA hsa-miR-139-5p HES4 -2.11299531796557 8.16407076415038e-28 1.31663345004462 8.38698816461316e-09 miRanda -0.263303480362385 1.25770285527951e-06 NA NA NA hsa-miR-224-3p HGF 1.40770116795301 1.31426607144612e-08 -3.45738625921135 1.44942707549128e-24 mirMAP -0.24700467708681 0.000422016473692453 NA NA NA hsa-miR-30d-5p HGF 0.718283816348023 2.47422074061352e-08 -3.45738625921135 1.44942707549128e-24 mirMAP -0.636747615843547 1.6663430655982e-06 NA NA NA hsa-miR-3682-3p HGF 0.805600143458555 8.7874424633131e-06 -3.45738625921135 1.44942707549128e-24 mirMAP -0.322825191529333 0.00118766446680551 NA NA NA hsa-miR-421 HGF 0.941856334694081 6.12167297054077e-08 -3.45738625921135 1.44942707549128e-24 miRanda -0.37483532054751 0.00015557960010186 NA NA NA hsa-miR-616-5p HGF 0.150569904638223 0.402836556304524 -3.45738625921135 1.44942707549128e-24 mirMAP -0.329885938670236 0.000709899554621757 NA NA NA hsa-miR-199a-3p HIC2 -2.3279328685682 1.04468066198593e-17 0.940776893137958 6.46839631810595e-09 miRNATAP -0.10985927757838 9.96318824478023e-05 NA NA NA hsa-miR-199b-3p HIC2 -2.33226605401203 9.51887435273314e-18 0.940776893137958 6.46839631810595e-09 miRNATAP -0.109906594475019 9.77758065151478e-05 NA NA NA hsa-miR-224-5p HIPK3 2.67175249172213 1.46995328399796e-18 -1.50429429958896 1.36124385011385e-07 MirTarget -0.168589163113438 0.000138084568295112 NA NA NA hsa-miR-424-5p HIST1H2BK -2.62653257498508 2.38997974737991e-50 0.696336365269723 3.05310643575151e-05 miRNAWalker2_validate -0.239492951965435 3.35454071954224e-09 NA NA NA hsa-miR-424-5p HIST2H2AA3 -2.62653257498508 2.38997974737991e-50 0.686853633246475 0.00104315095651271 miRNAWalker2_validate -0.275038087282255 6.15331093234648e-08 NA NA NA hsa-miR-139-5p HIST2H4A -2.11299531796557 8.16407076415038e-28 1.83376513541682 7.16184317924299e-23 miRanda -0.294796102708045 8.63253715393767e-11 NA NA NA hsa-miR-139-5p HM13 -2.11299531796557 8.16407076415038e-28 0.613339424464198 7.99869970795878e-11 miRanda -0.173530048819985 2.76068489557898e-15 NA NA NA hsa-miR-424-5p HMGA1 -2.62653257498508 2.38997974737991e-50 1.52957485940098 1.79164981120061e-17 miRNATAP -0.223547591779556 8.16486652332013e-07 NA NA NA hsa-miR-33b-5p HMGA2 -2.28852395459234 2.69046626645242e-22 1.11519648679255 0.015940340984894 MirTarget -0.396935736295752 1.26377908941702e-05 27609581;25868853;25725129 The expression and significance of miR 33b and HMGA2 in esophageal squamous cell carcinoma; Objective To investigate the expression and significance of miR-33b and high mobility group AT-hook 2 HMGA2 in esophageal squamous cell carcinoma ESCC; Methods Real-time quantitative PCR qRT-PCR was used to detect the expression levels of miR-33b and HMGA2 mRNA from the ESCC and adjacent tissues; After the miR-33b mimics inhibitor and controls were separately transfected into TE-1 and Eca-109 cells the expression levels of miR-33b and HMGA2 in each group were again determined by qRT-PCR and Western blotting; The expression level of miR-33b in the HMGA2 positive group was lower than that in the HMGA2 negative group; The correlation analysis showed that the expression of miR-33b was negatively correlated with the mRNA expression of HMGA2 in the ESCC tissues; There were no significant difference in the mRNA expression of HMGA2 among the cells transfected separately with miR-33b mimics inhibitor and controls but Western blotting indicated that the protein expression of HMGA2 decreased significantly in the miR-33b over-expressed cells; Conclusion The expression of miR-33b decreases and HMGA2 increases in the ESCC tissues;By targeting HMGA2 and Twist1 miR-33b attenuated melanoma migration and invasiveness upon cordycepin exposure;MicroRNA 33b upregulated by EF24 a curcumin analog suppresses the epithelial to mesenchymal transition EMT and migratory potential of melanoma cells by targeting HMGA2; miR-33b directly bound to HMGA2 3' untranslated region 3'-UTR to suppress its expression as measured by dual-luciferase assay; Thus the results suggest that EF24 suppresses melanoma metastasis via upregulating miR-33b and concomitantly reducing HMGA2 expression ;;metastasis esophageal cancer;melanoma;melanoma hsa-miR-3607-3p HMGA2 -2.15518588554493 1.03390728226728e-23 1.11519648679255 0.015940340984894 mirMAP -0.308271979274254 0.00190249533710306 NA NA NA hsa-miR-139-5p HMGB2 -2.11299531796557 8.16407076415038e-28 1.20191353886444 7.69561341921783e-18 miRanda -0.328825614226305 3.69157267147081e-24 NA NA NA hsa-miR-3607-3p HMGB2 -2.15518588554493 1.03390728226728e-23 1.20191353886444 7.69561341921783e-18 MirTarget -0.159997509473462 2.11000381139376e-07 NA NA NA hsa-miR-139-5p HMGN2 -2.11299531796557 8.16407076415038e-28 0.278581084665042 0.00450901587431376 miRanda -0.101329638451681 1.01164287902432e-05 NA NA NA hsa-miR-424-5p HNF1A -2.62653257498508 2.38997974737991e-50 0.217164609385192 0.10308623634593 mirMAP -0.207359334149785 7.60895636691415e-11 NA NA NA hsa-miR-10b-3p HNF1B 2.77189254628215 2.26687582932628e-20 -0.748947898308879 0.0139524691133734 MirTarget -0.21200278168503 2.98245078447638e-05 NA NA NA hsa-miR-424-5p HNRNPA1 -2.62653257498508 2.38997974737991e-50 0.655818468699744 1.34002254508707e-12 miRNATAP -0.163173341045243 4.89423363022143e-13 NA NA NA hsa-miR-139-5p HNRNPU -2.11299531796557 8.16407076415038e-28 0.372334227200183 2.90242784280694e-12 miRanda -0.119804871117008 4.13458097008048e-23 NA NA NA hsa-miR-139-5p HOMER1 -2.11299531796557 8.16407076415038e-28 -0.0763641412081514 0.796151529043688 miRanda -0.267156507727504 0.000114980968432196 NA NA NA hsa-miR-224-5p HORMAD2 2.67175249172213 1.46995328399796e-18 -2.20747189021449 9.87041933364421e-08 MirTarget -0.148116940514696 0.0218315209598513 NA NA NA hsa-miR-139-5p HOXA10 -2.11299531796557 8.16407076415038e-28 3.42398413145372 4.35734270924277e-13 miRanda -0.697204139469087 6.16320483460482e-10 NA NA NA hsa-miR-3607-3p HOXA11 -2.15518588554493 1.03390728226728e-23 1.63292702599355 4.17616774053981e-06 miRNATAP -0.471997227112097 4.03439519994018e-10 NA NA NA hsa-miR-139-5p HOXA13 -2.11299531796557 8.16407076415038e-28 4.75330371864711 5.73667967353751e-22 miRanda -0.633420503877592 1.73541722510064e-07 NA NA NA hsa-miR-3607-3p HOXA13 -2.15518588554493 1.03390728226728e-23 4.75330371864711 5.73667967353751e-22 mirMAP -0.675737120674386 6.87185449346152e-10 NA NA NA hsa-miR-424-5p HOXA3 -2.62653257498508 2.38997974737991e-50 1.48886412457132 4.60517706445809e-06 miRNATAP -0.373184486147257 2.80264464881814e-06 NA NA NA hsa-miR-139-5p HOXB9 -2.11299531796557 8.16407076415038e-28 1.2945297060988 0.000123494835110063 miRanda -0.441057106089933 2.31661301355372e-08 NA NA NA hsa-miR-139-5p HOXD10 -2.11299531796557 8.16407076415038e-28 2.06355989411511 2.58539753393107e-08 PITA;miRanda -0.694796235136023 5.93949413478084e-16 NA NA NA hsa-let-7a-5p HRAS -0.328069937201898 0.000464344093744051 0.80680940319204 2.11618137601331e-10 miRNAWalker2_validate;miRTarBase -0.411742589318827 6.60009421951558e-10 20607356;23134218;18344688;20033209;19323605 Transfection of let-7 miRNA reduced expression of pan-RAS N-RAS and K-RAS in the glioblastoma cells;MicroRNA let 7a inhibits the proliferation and invasion of nonsmall cell lung cancer cell line 95D by regulating K Ras and HMGA2 gene expression; K-RAS and HMGA2 mRNA levels were significantly higher in the let-7a overexpressed group than those in the let-7a inhibited group p < 0.05; However the protein levels of K-RAS and HMGA2 were significantly lower in the let-7a overexpressed group than those in the let-7a inhibited group p < 0.05; We suppose that let-7a inhibits the proliferation and invasion of the cell line 95D by regulating the translation of K-RAS and HMGA2 mRNA not the transcription of the mRNA itself;Using an established orthotopic mouse lung cancer model we show that intranasal let-7 administration reduces tumor formation in vivo in the lungs of animals expressing a G12D activating mutation for the K-ras oncogene;k-Ras and c-Myc two key oncogenes in lung cancer have been found to be targeted by let-7 in vitro; The aim of the present study is to determine the effect of let-7a a member of let-7 family on the growth of lung cancer in vivo and to investigate whether let-7-induced suppression of k-Ras and c-Myc is involved in lung cancer; Overexpression of let-7a can inhibit the growth of lung cancer transplanted subcutaneously in nude mice by suppression of k-Ras and c-Myc;Because let-7 microRNA targets the K-ras oncogene we aimed to characterize let-7 expression and function in PDAC in vitro and in vivo; Restoring let-7 levels in cancer-derived cell lines strongly inhibits cell proliferation K-ras expression and mitogen-activated protein kinase activation but fails to impede tumor growth progression after intratumoral gene transfer or after implantation of Capan-1 cells stably overexpressing let-7 microRNA ;;;;progression glioblastoma;lung squamous cell cancer;lung cancer;lung cancer;pancreatic cancer hsa-let-7b-5p HRAS -0.959013717270803 5.95127281258643e-11 0.80680940319204 2.11618137601331e-10 miRTarBase -0.270772577779286 5.9733154777202e-11 20607356;20881268;18344688;20033209;19323605 Transfection of let-7 miRNA reduced expression of pan-RAS N-RAS and K-RAS in the glioblastoma cells;On the basis of these data we suggest that the downregulation of let-7b and let-7e targeting K-ras and the upregulation of miR-17* a CRC marker could be considered as candidate molecular markers of cetuximab resistance;Using an established orthotopic mouse lung cancer model we show that intranasal let-7 administration reduces tumor formation in vivo in the lungs of animals expressing a G12D activating mutation for the K-ras oncogene;k-Ras and c-Myc two key oncogenes in lung cancer have been found to be targeted by let-7 in vitro; The aim of the present study is to determine the effect of let-7a a member of let-7 family on the growth of lung cancer in vivo and to investigate whether let-7-induced suppression of k-Ras and c-Myc is involved in lung cancer;Because let-7 microRNA targets the K-ras oncogene we aimed to characterize let-7 expression and function in PDAC in vitro and in vivo; Restoring let-7 levels in cancer-derived cell lines strongly inhibits cell proliferation K-ras expression and mitogen-activated protein kinase activation but fails to impede tumor growth progression after intratumoral gene transfer or after implantation of Capan-1 cells stably overexpressing let-7 microRNA ;drug resistance;;;progression glioblastoma;colorectal cancer;lung cancer;lung cancer;pancreatic cancer hsa-miR-143-3p HRAS -0.584123869220553 0.000907217687997436 0.80680940319204 2.11618137601331e-10 miRNAWalker2_validate;miRTarBase -0.141161766298964 7.30370553951274e-05 21276449 The Evi1 microRNA 143 K Ras axis in colon cancer colon cancer hsa-miR-139-5p HRH1 -2.11299531796557 8.16407076415038e-28 0.340287230286828 0.0286188640920779 miRanda -0.153945526606647 2.38284353320096e-05 NA NA NA hsa-miR-424-5p HS6ST1 -2.62653257498508 2.38997974737991e-50 0.210457102457243 0.127079352263565 mirMAP -0.14495679574945 1.46903374789788e-05 NA NA NA hsa-miR-3607-3p HS6ST2 -2.15518588554493 1.03390728226728e-23 -0.0158151904707768 0.972541683951241 miRNATAP -0.292340932918482 0.0029387148509124 NA NA NA hsa-miR-139-5p HSF2 -2.11299531796557 8.16407076415038e-28 0.59187321228126 7.06161260636529e-09 miRanda -0.147161082057784 9.24992262924978e-10 NA NA NA hsa-miR-139-5p HSP90AB2P -2.11299531796557 8.16407076415038e-28 1.0026993319179 1.88882764982217e-07 miRanda -0.139568921368209 0.002392390022431 NA NA NA hsa-miR-139-5p HSPA14 -2.11299531796557 8.16407076415038e-28 0.503829750525249 1.05868962915457e-11 miRanda -0.119868776204835 5.62853425112557e-12 NA NA NA hsa-miR-139-5p HSPH1 -2.11299531796557 8.16407076415038e-28 0.548171480625511 7.28210971283888e-07 miRanda -0.114492636346473 1.22239493391818e-05 NA NA NA hsa-miR-144-3p HTRA3 -2.97536914478815 6.00546047309683e-28 0.0343663892215949 0.913601530352526 miRNATAP -0.183161867930411 0.000527204635280295 NA NA NA hsa-miR-424-5p HTT -2.62653257498508 2.38997974737991e-50 0.396234962853412 2.19371471763879e-06 MirTarget -0.101288509122174 6.86947527102193e-07 NA NA NA hsa-miR-3607-3p HUNK -2.15518588554493 1.03390728226728e-23 -0.720733679971585 0.0531352542804175 miRNATAP -0.224446468757932 0.00499558431682678 NA NA NA hsa-miR-424-5p IARS -2.62653257498508 2.38997974737991e-50 0.584806432735134 3.98473217675824e-10 miRNAWalker2_validate;MirTarget -0.103089926164614 8.1588137303481e-06 NA NA NA hsa-miR-139-5p IBSP -2.11299531796557 8.16407076415038e-28 1.92420097521516 4.21531465173415e-07 miRanda -0.741449456478811 2.42397138345038e-17 NA NA NA hsa-miR-183-5p ICK 2.33444328833177 1.52188109365421e-10 0.39119996904083 0.0104331872491703 miRNATAP -0.109871771600887 2.33042823411131e-08 NA NA NA hsa-miR-139-5p IGDCC4 -2.11299531796557 8.16407076415038e-28 1.73062068710294 1.15353341113415e-06 miRanda -0.49810929326372 2.48890513381712e-09 NA NA NA hsa-miR-3607-3p IGDCC4 -2.15518588554493 1.03390728226728e-23 1.73062068710294 1.15353341113415e-06 miRNATAP -0.375590035569781 9.11331532211109e-07 NA NA NA hsa-miR-103a-2-5p IGF1 1.17085533927423 5.31418969120877e-09 -3.09093589123239 2.87389370715384e-21 mirMAP -0.263504392304743 0.00223342792049484 NA NA NA hsa-miR-15b-3p IGF1 0.238105490431193 0.0997721500357416 -3.09093589123239 2.87389370715384e-21 mirMAP -0.317736514699582 0.00624882495536213 NA NA NA hsa-miR-181a-5p IGF1 0.250113435902954 0.0551933249319293 -3.09093589123239 2.87389370715384e-21 mirMAP -0.504463915639783 8.50109868625984e-05 NA NA NA hsa-miR-181b-5p IGF1 0.488256489401108 0.00105321129419701 -3.09093589123239 2.87389370715384e-21 mirMAP -0.623738116833257 1.69561535563835e-08 NA NA NA hsa-miR-181c-5p IGF1 -0.00639394152050299 0.969127212255928 -3.09093589123239 2.87389370715384e-21 mirMAP -0.239250410659019 0.01885120596434 NA NA NA hsa-miR-19a-3p IGF1 1.01712596153672 2.57753201450625e-07 -3.09093589123239 2.87389370715384e-21 MirTarget -0.400144846493838 1.38857829477185e-06 NA NA NA hsa-miR-19b-3p IGF1 0.601279551368824 0.00016685097085251 -3.09093589123239 2.87389370715384e-21 MirTarget -0.48361890440052 2.97870836726975e-06 NA NA NA hsa-miR-20a-3p IGF1 -0.318177901603857 0.0467885456739855 -3.09093589123239 2.87389370715384e-21 mirMAP -0.361896843485159 0.00054680673837891 NA NA NA hsa-miR-301a-3p IGF1 0.842910511640361 1.43446467417891e-06 -3.09093589123239 2.87389370715384e-21 MirTarget -0.644215183857533 3.25465618219484e-12 NA NA NA hsa-miR-320a IGF1 0.325285936317332 0.0221415065838824 -3.09093589123239 2.87389370715384e-21 miRNATAP -0.253507903136112 0.0320941317708595 NA NA NA hsa-miR-361-5p IGF1 0.233202959858696 0.00961572812255327 -3.09093589123239 2.87389370715384e-21 PITA;mirMAP -0.379123489406991 0.0443597193507629 NA NA NA hsa-miR-362-5p IGF1 0.717921690799312 1.68392734504524e-05 -3.09093589123239 2.87389370715384e-21 mirMAP -0.221743789905403 0.026284257397644 NA NA NA hsa-miR-369-3p IGF1 -0.680843625018478 0.0155063508282041 -3.09093589123239 2.87389370715384e-21 mirMAP -0.150353974270175 0.0114686163117569 NA NA NA hsa-miR-3913-5p IGF1 0.247553671224336 0.062795011081188 -3.09093589123239 2.87389370715384e-21 mirMAP -0.347700367785319 0.00609623314715803 NA NA NA hsa-miR-409-3p IGF1 -0.499649792570937 0.0526751181520117 -3.09093589123239 2.87389370715384e-21 PITA -0.129530044963349 0.0462392123008723 NA NA NA hsa-miR-421 IGF1 0.941856334694081 6.12167297054077e-08 -3.09093589123239 2.87389370715384e-21 PITA -0.472083397878338 5.5786740474017e-07 NA NA NA hsa-miR-454-3p IGF1 0.668749059573955 2.42670710515113e-06 -3.09093589123239 2.87389370715384e-21 MirTarget -0.659716525935208 1.08682616687143e-08 NA NA NA hsa-miR-485-3p IGF1 -0.429504552347863 0.165399880918286 -3.09093589123239 2.87389370715384e-21 mirMAP -0.125118787170308 0.0219899962644741 NA NA NA hsa-miR-940 IGF1 0.453020092551484 0.0177054921651997 -3.09093589123239 2.87389370715384e-21 MirTarget;PITA;miRNATAP -0.258190444399689 0.00419588966919949 NA NA NA hsa-miR-122-5p IGF1R -1.23907441373955 4.42181244888642e-06 -0.704819576268303 0.00353845530141102 miRNAWalker2_validate;miRTarBase;miRNATAP -0.36918930122591 5.43953757427132e-19 19726678;23056576 Expression of SRF or Igf1R partially reversed tumor suppressor function of miR-122;MiR 122 inhibits cell proliferation and tumorigenesis of breast cancer by targeting IGF1R; We then screened and identified a novel miR-122 target insulin-like growth factor 1 receptor IGF1R and it was further confirmed by luciferase assay; Similar to the restoring miR-122 expression IGF1R downregulation suppressed cell growth and cell-cycle progression whereas IGF1R overexpression rescued the suppressive effect of miR-122; In clinical specimens IGF1R was widely overexpressed and its mRNA levels were inversely correlated with miR-122 expression; Taken together our results demonstrate that miR-122 functions as a tumor suppressor and plays an important role in inhibiting the tumorigenesis through targeting IGF1R and regulating PI3K/Akt/mTOR/p70S6K pathway ;tumorigenesis;progression liver cancer;breast cancer hsa-miR-1269a IGF1R 3.57543539205634 4.25369619949175e-08 -0.704819576268303 0.00353845530141102 mirMAP -0.107248654580264 5.68720148437858e-09 NA NA NA hsa-miR-140-3p IGF1R 0.546012239205329 4.84578261098777e-11 -0.704819576268303 0.00353845530141102 mirMAP -0.466711989272837 0.000930505583515681 24039995 Integrated analysis identified IGF1R as a direct and functional target of miR-140; Knockdown of IGF1R inhibited cell proliferation and invasion resembling that of miR-140 overexpression while overexpression of IGF1R attenuated the function of miR-140 in NSCLC cells; Together our results highlight the significance of miR-140 and IGF1R in the development and progression of NSCLC progression lung squamous cell cancer hsa-miR-146b-5p IGF1R 0.419719546795449 0.0457375823220155 -0.704819576268303 0.00353845530141102 miRanda -0.13076910673127 0.0201657634972399 NA NA NA hsa-miR-148a-5p IGF1R -0.767626696027761 1.08359477494797e-06 -0.704819576268303 0.00353845530141102 mirMAP -0.626014741533492 1.69198276385715e-18 NA NA NA hsa-miR-15a-5p IGF1R 0.349521211668244 0.000770735998804736 -0.704819576268303 0.00353845530141102 miRNATAP -0.46922259656765 3.61522699850867e-05 NA NA NA hsa-miR-16-1-3p IGF1R 0.392360028038559 0.00112481918108198 -0.704819576268303 0.00353845530141102 mirMAP -0.495470276550512 3.45124137757538e-07 NA NA NA hsa-miR-192-5p IGF1R -0.50188499512787 0.00344713341196035 -0.704819576268303 0.00353845530141102 miRNAWalker2_validate -0.5797159058919 1.53799651190084e-18 NA NA NA hsa-miR-193a-5p IGF1R -0.472805720224262 1.24962968905481e-05 -0.704819576268303 0.00353845530141102 mirMAP -0.335338989012095 0.00208565024368226 NA NA NA hsa-miR-194-3p IGF1R -0.772747277805343 2.9537465170191e-05 -0.704819576268303 0.00353845530141102 MirTarget -0.465153354275548 4.12155219164854e-14 NA NA NA hsa-miR-194-5p IGF1R -0.292530160992458 0.0996141384876663 -0.704819576268303 0.00353845530141102 miRNAWalker2_validate;miRTarBase;miRNATAP -0.583365945764816 5.17802935579868e-20 NA NA NA hsa-miR-204-5p IGF1R -0.537962150012103 0.0330895493358849 -0.704819576268303 0.00353845530141102 mirMAP -0.175246151442439 0.000169572558257274 NA NA NA hsa-miR-33a-3p IGF1R -0.683025859637737 1.01106097756419e-05 -0.704819576268303 0.00353845530141102 miRNATAP -0.24024722365927 0.00153166064129096 NA NA NA hsa-miR-34a-5p IGF1R 1.03694231790865 5.74864019540594e-14 -0.704819576268303 0.00353845530141102 miRNAWalker2_validate -0.278122778996491 0.000818572922363686 NA NA NA hsa-miR-3613-5p IGF1R 0.108670896316992 0.426512924240953 -0.704819576268303 0.00353845530141102 mirMAP;miRNATAP -0.184878380000261 0.0338326133214546 NA NA NA hsa-miR-362-3p IGF1R 0.814007335895913 2.00108618836568e-09 -0.704819576268303 0.00353845530141102 PITA -0.261747556128077 0.0022443415729253 NA NA NA hsa-miR-365a-3p IGF1R 0.164591326307714 0.15325084963213 -0.704819576268303 0.00353845530141102 MirTarget -0.509016427701301 6.48840738830501e-07 NA NA NA hsa-miR-374a-5p IGF1R 0.016390363747302 0.869784217438621 -0.704819576268303 0.00353845530141102 mirMAP -0.390232878812442 0.00108904623272643 NA NA NA hsa-miR-374b-5p IGF1R -0.307538028546424 0.0030079617545972 -0.704819576268303 0.00353845530141102 mirMAP -0.281147914120267 0.0143487091586185 NA NA NA hsa-miR-378a-3p IGF1R -1.1920055906972 3.23538871733634e-10 -0.704819576268303 0.00353845530141102 miRTarBase;MirTarget;miRNATAP -0.309332132345512 2.97740860751599e-07 24119742;25427715;24412052 The insulin-like growth factor 1 receptor IGF1R was predicted as a potential target of miR-378 and luciferase reporter activity of IGF1R was significantly decreased in the HEK293 cells co-transfected with miR-378 by 41.8% vs the control cells P less than 0.01; miR-378 may suppress growth characteristics of HBV-related HCC by directly targeting the IGF1R 3'-UTR and inhibiting its protein expression;Interestingly members of the miR-378 family presented as a possible target the insulin-like growth factor receptor 1 IGF1R a key signalling molecule in RMS; MiR-378a-3p over-expression in an RMS-derived cell line suppressed IGF1R expression and affected phosphorylated-Akt protein levels;Furthermore miR-378a-3p over-expression or down-regulation could inhibit or enhance insulin-like growth factor 1 receptor IGF1R expression in CRC cells; There was a significantly negative correlation between IGF1R protein expression and miR-378a-3p expression in CRC tissues ;; liver cancer;sarcoma;colorectal cancer hsa-miR-378a-5p IGF1R -1.58667444700188 3.19640857320504e-17 -0.704819576268303 0.00353845530141102 mirMAP -0.264516472073392 1.03932054528896e-05 24119742;25427715 The insulin-like growth factor 1 receptor IGF1R was predicted as a potential target of miR-378 and luciferase reporter activity of IGF1R was significantly decreased in the HEK293 cells co-transfected with miR-378 by 41.8% vs the control cells P less than 0.01; miR-378 may suppress growth characteristics of HBV-related HCC by directly targeting the IGF1R 3'-UTR and inhibiting its protein expression;Interestingly members of the miR-378 family presented as a possible target the insulin-like growth factor receptor 1 IGF1R a key signalling molecule in RMS ; liver cancer;sarcoma hsa-miR-378c IGF1R -1.54028191929038 2.70131554214866e-15 -0.704819576268303 0.00353845530141102 MirTarget;miRNATAP -0.266498982003542 4.51608338557028e-06 NA NA NA hsa-miR-452-5p IGF1R 1.91544498799508 1.81995982853313e-14 -0.704819576268303 0.00353845530141102 mirMAP -0.13514669426121 0.00308740647279285 NA NA NA hsa-miR-455-5p IGF1R -0.270546034117157 0.0581320703577731 -0.704819576268303 0.00353845530141102 miRNATAP -0.33649940148595 4.6083750392036e-05 NA NA NA hsa-miR-500a-3p IGF1R 1.18913245435489 1.59516890341346e-16 -0.704819576268303 0.00353845530141102 mirMAP -0.24207363919467 0.00220221370587418 NA NA NA hsa-miR-532-5p IGF1R 1.02729546510601 9.93318913966636e-16 -0.704819576268303 0.00353845530141102 miRNATAP -0.594000411464035 1.11895616071031e-11 NA NA NA hsa-miR-616-5p IGF1R 0.150569904638223 0.402836556304524 -0.704819576268303 0.00353845530141102 mirMAP -0.341804564452571 1.5998912473218e-07 NA NA NA hsa-miR-885-5p IGF1R -0.940994379567566 0.00118729865914986 -0.704819576268303 0.00353845530141102 PITA;mirMAP -0.156220425611698 0.000105601334784438 NA NA NA hsa-miR-92a-3p IGF1R 0.212391012518195 0.134292268089997 -0.704819576268303 0.00353845530141102 miRNAWalker2_validate -0.183676168387297 0.028392302915822 NA NA NA hsa-miR-99a-5p IGF1R -1.51481656384839 3.93230057259529e-14 -0.704819576268303 0.00353845530141102 miRNAWalker2_validate;miRTarBase;miRNATAP -0.199500914226479 0.00046535126029909 22425712 Furthermore ectopic transfection of miR-99 family members down-regulated the expression of insulin-like growth factor 1 receptor IGF1R and mechanistic target of rapamycin mTOR genes; The deregulation of miR-99 family contributes to the tumorigenesis of HNSCC in part by targeting IGF1R and mTOR signaling pathways tumorigenesis head and neck cancer hsa-miR-130b-3p IGF2 0.687190305027546 0.000109068658562255 -3.69294069874179 5.99403820984858e-10 mirMAP -0.608939815790691 0.00023785677759273 NA NA NA hsa-miR-193b-5p IGF2 -0.748481053559202 3.37008423124215e-06 -3.69294069874179 5.99403820984858e-10 mirMAP -0.494111714929712 0.00687773918459788 NA NA NA hsa-miR-210-3p IGF2 -0.214021053143938 0.414999515823232 -3.69294069874179 5.99403820984858e-10 MirTarget -0.459707730579746 4.42072409976778e-05 NA NA NA hsa-miR-224-3p IGF2 1.40770116795301 1.31426607144612e-08 -3.69294069874179 5.99403820984858e-10 mirMAP -0.398994767968095 0.000807606270339222 NA NA NA hsa-miR-339-5p IGF2 0.280589919878422 0.0355660282647215 -3.69294069874179 5.99403820984858e-10 mirMAP -0.439074608066956 0.0498378270795433 NA NA NA hsa-miR-34a-5p IGF2 1.03694231790865 5.74864019540594e-14 -3.69294069874179 5.99403820984858e-10 mirMAP -1.25726555221864 9.83117679327442e-10 NA NA NA hsa-miR-361-3p IGF2 0.275658012727111 0.00549374744374488 -3.69294069874179 5.99403820984858e-10 mirMAP -0.840984123439573 0.00529861999876599 NA NA NA hsa-miR-365a-3p IGF2 0.164591326307714 0.15325084963213 -3.69294069874179 5.99403820984858e-10 MirTarget -0.534903960709602 0.039897028045714 NA NA NA hsa-miR-491-5p IGF2 -0.369122930844418 0.0154047757048929 -3.69294069874179 5.99403820984858e-10 MirTarget;miRanda -0.541797058750972 0.00597257160148499 NA NA NA hsa-miR-9-5p IGF2 1.26407994492898 8.53156156439881e-05 -3.69294069874179 5.99403820984858e-10 mirMAP -0.449689855202211 6.84845043601393e-07 NA NA NA hsa-miR-33b-5p IGF2BP1 -2.28852395459234 2.69046626645242e-22 4.99826974747196 9.59227871105866e-16 mirMAP -0.719927304832693 9.78776866076461e-09 NA NA NA hsa-miR-224-5p IGFBP3 2.67175249172213 1.46995328399796e-18 -2.55803658929415 1.7955269745611e-33 MirTarget -0.174025915145798 6.44207387905941e-07 NA NA NA hsa-miR-224-5p IGFBP5 2.67175249172213 1.46995328399796e-18 -0.795485319301285 0.00081396472061437 mirMAP -0.144475965777688 7.30151853626311e-05 NA NA NA hsa-miR-10b-5p IGLON5 2.86931593037303 6.97409423207806e-23 -2.68738913425682 7.72186225143093e-17 mirMAP -0.310970516089846 2.48581552388667e-09 NA NA NA hsa-miR-424-5p IHH -2.62653257498508 2.38997974737991e-50 0.632640626857695 0.047987439600247 MirTarget;miRNATAP -0.207433575074311 0.0080932822980365 NA NA NA hsa-miR-125a-5p IKBKG -0.91219969372382 1.38256246489548e-07 0.660366120199928 1.71867865546723e-06 miRanda -0.219029418282295 9.51829321882113e-09 NA NA NA hsa-miR-143-3p IKBKG -0.584123869220553 0.000907217687997436 0.660366120199928 1.71867865546723e-06 mirMAP -0.169551761758995 9.09905571393035e-06 NA NA NA hsa-miR-200a-3p IKBKG -1.49949292595657 3.18410995256133e-05 0.660366120199928 1.71867865546723e-06 mirMAP -0.100439586597671 5.62621816828972e-08 NA NA NA hsa-miR-24-3p IKBKG -0.257825594021966 0.00689742600215061 0.660366120199928 1.71867865546723e-06 mirMAP -0.287544034512102 5.8686253015948e-05 NA NA NA hsa-miR-3065-3p IKBKG -1.04244468016704 4.60743424372577e-05 0.660366120199928 1.71867865546723e-06 mirMAP -0.115721435331344 9.61381024877344e-06 NA NA NA hsa-miR-320a IKBKG 0.325285936317332 0.0221415065838824 0.660366120199928 1.71867865546723e-06 mirMAP -0.182311319218153 0.000133876392194021 NA NA NA hsa-miR-320b IKBKG 0.0919652022571331 0.607981643616945 0.660366120199928 1.71867865546723e-06 mirMAP -0.132285547849802 0.000522961413620221 NA NA NA hsa-miR-330-3p IKBKG -0.332364259424489 0.0316051913061459 0.660366120199928 1.71867865546723e-06 mirMAP -0.111083773167518 0.0137533606676294 NA NA NA hsa-miR-335-5p IKBKG -1.61347836513558 1.62757083289711e-19 0.660366120199928 1.71867865546723e-06 mirMAP -0.273399124951207 9.32430291537739e-15 NA NA NA hsa-miR-338-5p IKBKG -0.221898432884726 0.252390988727086 0.660366120199928 1.71867865546723e-06 mirMAP -0.206675822417303 2.68501101428877e-09 NA NA NA hsa-miR-376c-3p IKBKG -1.78544013329054 1.82972185127691e-10 0.660366120199928 1.71867865546723e-06 mirMAP -0.14083607992738 1.85430800686914e-09 NA NA NA hsa-miR-542-3p IKBKG -1.31351015149842 3.64642423288576e-22 0.660366120199928 1.71867865546723e-06 mirMAP -0.292142688932618 4.40119371820177e-10 NA NA NA hsa-miR-3607-3p IL17RD -2.15518588554493 1.03390728226728e-23 -0.125343297177237 0.609800523271957 mirMAP -0.124264902552961 0.0182206089387269 NA NA NA hsa-miR-224-5p IL1RN 2.67175249172213 1.46995328399796e-18 -2.23261438990738 7.31816117114961e-19 MirTarget -0.104398522220829 0.00970593189890033 NA NA NA hsa-miR-3607-3p IL2RA -2.15518588554493 1.03390728226728e-23 0.180571782655739 0.552548214272016 mirMAP -0.138381350520055 0.0338272996873419 NA NA NA hsa-miR-139-5p ILDR1 -2.11299531796557 8.16407076415038e-28 -0.599551237471297 0.151875900452758 miRanda -0.312249847318304 0.00151919763231548 NA NA NA hsa-miR-3607-3p ILF3 -2.15518588554493 1.03390728226728e-23 0.831990094155143 7.82598568301071e-32 miRNATAP -0.137422547678169 1.87717942599884e-18 NA NA NA hsa-miR-139-5p INPP5J -2.11299531796557 8.16407076415038e-28 1.51506447952545 5.95748863803298e-08 miRanda -0.586235392563202 5.18689603460008e-20 NA NA NA hsa-miR-183-5p INSIG1 2.33444328833177 1.52188109365421e-10 -0.982451848864065 0.000118571254506076 miRNAWalker2_validate -0.214098860160619 7.1209039492568e-11 NA NA NA hsa-let-7e-5p INSR 0.0350298755544731 0.811068614727804 -0.278293402111066 0.00785689311731476 miRNATAP -0.217076706682375 2.52676832104311e-10 NA NA NA hsa-let-7i-5p INSR -0.14267936165213 0.154141689875847 -0.278293402111066 0.00785689311731476 miRNATAP -0.202914490507566 7.59063234403437e-05 NA NA NA hsa-miR-103a-2-5p INSR 1.17085533927423 5.31418969120877e-09 -0.278293402111066 0.00785689311731476 mirMAP -0.143764638707222 2.91318714410811e-08 NA NA NA hsa-miR-140-3p INSR 0.546012239205329 4.84578261098777e-11 -0.278293402111066 0.00785689311731476 mirMAP -0.27738473170784 4.52228010800238e-06 NA NA NA hsa-miR-142-5p INSR -1.44575553250033 1.18797044680592e-13 -0.278293402111066 0.00785689311731476 mirMAP -0.110475843753827 1.18266898108668e-05 NA NA NA hsa-miR-151a-3p INSR 0.330888909161891 0.00418075524865448 -0.278293402111066 0.00785689311731476 miRNATAP -0.115231259307582 0.00938434743719466 NA NA NA hsa-miR-15a-5p INSR 0.349521211668244 0.000770735998804736 -0.278293402111066 0.00785689311731476 miRNATAP -0.251138215261527 2.59574923914891e-07 NA NA NA hsa-miR-15b-3p INSR 0.238105490431193 0.0997721500357416 -0.278293402111066 0.00785689311731476 mirMAP -0.206937351548888 2.77089790710962e-09 NA NA NA hsa-miR-15b-5p INSR 0.230566941413564 0.0824765001857479 -0.278293402111066 0.00785689311731476 miRNATAP -0.186808144180658 1.02375284487422e-06 NA NA NA hsa-miR-16-5p INSR -0.398577235179603 0.000101598495180191 -0.278293402111066 0.00785689311731476 miRNATAP -0.148270888544752 0.00293111089224694 NA NA NA hsa-miR-181a-5p INSR 0.250113435902954 0.0551933249319293 -0.278293402111066 0.00785689311731476 mirMAP -0.196102420475405 4.52506455097139e-07 NA NA NA hsa-miR-181b-5p INSR 0.488256489401108 0.00105321129419701 -0.278293402111066 0.00785689311731476 mirMAP -0.192792987659091 1.02091731606267e-08 NA NA NA hsa-miR-181c-5p INSR -0.00639394152050299 0.969127212255928 -0.278293402111066 0.00785689311731476 mirMAP -0.144920155303009 2.39135053897472e-06 NA NA NA hsa-miR-186-5p INSR -0.060103391373687 0.535288717081205 -0.278293402111066 0.00785689311731476 mirMAP -0.275991289305386 1.62425713237588e-07 NA NA NA hsa-miR-21-5p INSR 1.51084295924322 1.54551622173259e-34 -0.278293402111066 0.00785689311731476 mirMAP -0.133506275914425 0.00045620211593194 24804226;27220494;21618027 Downregulation of miR-21 in radioresistant NSCLC A549 cells inhibited the colony-forming ability and proliferation of A549 cells after IR; Moreover silencing miR-21 enhanced apoptosis of A549 cells induced by IR accompanied by decreased phosphorylated-Akt protein level; However PI3K activator IGF-1 reversed suppression of phosphorylated-Akt protein level and promotion of apoptosis of A549 cells after IR caused by miR-21 knockdown; Silencing miR-21 in radioresistant NSCLC A549 cells sensitized them to IR by inhibiting cell proliferation and enhancing cell apoptosis through inhibition of PI3K/Akt signaling pathway;In addition we also demonstrated that miR-21 confers decreased autophagy in cervical cancer cells after IR via the Akt-mTOR signaling pathway;In this study we found that miR-21 expression was upregulated in response to ionizing radiation IR in U251 cells which suggested that miR-21 could be involved in the response of U251 cells to radiation; We showed that a miR-21 inhibitor enhanced IR-induced glioblastoma cell growth arrest and increased the level of apoptosis which was probably caused by abrogation of the G2-M arrest induced by IR ;;drug resistance lung squamous cell cancer;cervical and endocervical cancer;glioblastoma hsa-miR-27a-3p INSR -0.370807380415112 0.00875721956202713 -0.278293402111066 0.00785689311731476 miRNATAP -0.129448246537712 0.000323191383525876 NA NA NA hsa-miR-32-3p INSR 0.219109440121582 0.207217051619543 -0.278293402111066 0.00785689311731476 mirMAP -0.108738122811479 0.000332795668307009 NA NA NA hsa-miR-330-3p INSR -0.332364259424489 0.0316051913061459 -0.278293402111066 0.00785689311731476 mirMAP -0.105204122509177 0.00182847295060521 NA NA NA hsa-miR-330-5p INSR 0.442231058604099 0.0053308560843808 -0.278293402111066 0.00785689311731476 miRanda -0.124285365243876 0.000101730606261174 NA NA NA hsa-miR-342-3p INSR -0.319677314984262 0.0449813878317147 -0.278293402111066 0.00785689311731476 miRanda -0.16761426288179 1.19136840204847e-07 NA NA NA hsa-miR-361-5p INSR 0.233202959858696 0.00961572812255327 -0.278293402111066 0.00785689311731476 miRanda -0.250639357997155 1.06114867503819e-05 NA NA NA hsa-miR-501-5p INSR 1.15231083477882 2.98906150004088e-10 -0.278293402111066 0.00785689311731476 miRNATAP -0.176376064204615 4.45936602190125e-11 NA NA NA hsa-miR-582-3p INSR -0.653831905315466 0.00248607706603299 -0.278293402111066 0.00785689311731476 mirMAP -0.111253922145084 1.79374163017854e-06 NA NA NA hsa-miR-590-3p INSR -0.473167498047808 1.76652934637227e-05 -0.278293402111066 0.00785689311731476 PITA;miRanda;mirMAP;miRNATAP -0.113790161184604 0.0139230267708451 NA NA NA hsa-miR-590-5p INSR -0.103355559980404 0.310027295317092 -0.278293402111066 0.00785689311731476 mirMAP -0.29804167588886 2.22806193728684e-09 NA NA NA hsa-miR-7-1-3p INSR -0.569105143287799 1.85297665041424e-05 -0.278293402111066 0.00785689311731476 mirMAP -0.122187054321131 0.00135939582701306 NA NA NA hsa-miR-139-5p INTU -2.11299531796557 8.16407076415038e-28 0.673272527277211 0.0010627250704584 miRanda -0.204754589364521 2.3298175295153e-05 NA NA NA hsa-miR-139-5p IP6K1 -2.11299531796557 8.16407076415038e-28 0.889516693961123 4.04556190796781e-31 miRanda -0.161018710477957 6.27378339162672e-18 NA NA NA hsa-miR-424-5p IP6K1 -2.62653257498508 2.38997974737991e-50 0.889516693961123 4.04556190796781e-31 MirTarget -0.187720670593291 9.30587869536704e-23 NA NA NA hsa-miR-424-5p IPO9 -2.62653257498508 2.38997974737991e-50 0.702597699750934 1.89164484084094e-17 miRNATAP -0.169056126415937 5.85551112819939e-17 NA NA NA hsa-miR-139-5p IQCA1 -2.11299531796557 8.16407076415038e-28 -0.044268167339232 0.861046216288703 miRanda -0.145451757016966 0.0146198800959025 NA NA NA hsa-miR-33b-5p IQCE -2.28852395459234 2.69046626645242e-22 1.21246761004316 4.22270897620511e-25 mirMAP -0.116887310417858 1.51970281528034e-06 NA NA NA hsa-miR-424-5p IRF2BP2 -2.62653257498508 2.38997974737991e-50 0.396933582427944 3.07177177732261e-06 miRNATAP -0.113805162280088 3.63689988463431e-08 NA NA NA hsa-miR-139-5p IRGQ -2.11299531796557 8.16407076415038e-28 0.902560453855328 7.48220981072122e-23 mirMAP -0.169195786138656 1.84068609604761e-14 NA NA NA hsa-miR-199a-3p IRGQ -2.3279328685682 1.04468066198593e-17 0.902560453855328 7.48220981072122e-23 mirMAP -0.105552975749722 8.62026562734858e-11 NA NA NA hsa-miR-199b-3p IRGQ -2.33226605401203 9.51887435273314e-18 0.902560453855328 7.48220981072122e-23 mirMAP -0.105417801519745 8.84263357955391e-11 NA NA NA hsa-miR-183-5p IRS1 2.33444328833177 1.52188109365421e-10 -0.221383948238947 0.137544848662312 MirTarget;miRNATAP -0.15378452060776 2.32414530343982e-16 NA NA NA hsa-miR-3607-3p ISLR2 -2.15518588554493 1.03390728226728e-23 -0.0413806397920418 0.867877227387776 mirMAP -0.162541822257047 0.00223904321073769 NA NA NA hsa-miR-139-5p ITGA2 -2.11299531796557 8.16407076415038e-28 1.53120134028147 5.03620431516659e-09 PITA;miRanda -0.348713430392277 1.86833411063269e-08 NA NA NA hsa-miR-3607-3p ITGA2 -2.15518588554493 1.03390728226728e-23 1.53120134028147 5.03620431516659e-09 mirMAP -0.173252523084354 0.0024333016929685 NA NA NA hsa-miR-139-5p ITGA3 -2.11299531796557 8.16407076415038e-28 0.331189713134492 0.166738416790431 PITA;miRanda -0.174245423626721 0.00198897109798136 NA NA NA hsa-miR-199a-3p ITGA6 -2.3279328685682 1.04468066198593e-17 1.33116884445099 5.73067512733422e-21 PITA -0.166829140227348 2.64008048809431e-11 NA NA NA hsa-miR-199b-3p ITGA6 -2.33226605401203 9.51887435273314e-18 1.33116884445099 5.73067512733422e-21 PITA -0.166957893782338 2.45787733398932e-11 NA NA NA hsa-miR-139-5p ITGB3BP -2.11299531796557 8.16407076415038e-28 0.953203122300039 2.66983872178117e-15 miRanda -0.244901070582902 4.18371366116594e-18 NA NA NA hsa-miR-10b-3p IYD 2.77189254628215 2.26687582932628e-20 -2.66179429977146 1.10383788101266e-13 mirMAP -0.289319090199637 2.38245070836375e-06 NA NA NA hsa-miR-3607-3p JAG2 -2.15518588554493 1.03390728226728e-23 1.63935349038013 5.44903322246813e-19 miRNATAP -0.236898029698969 5.5004048106838e-09 NA NA NA hsa-miR-139-5p JAK3 -2.11299531796557 8.16407076415038e-28 -0.0341347925675266 0.875605617465597 miRanda -0.183410063739571 0.000335328682413109 NA NA NA hsa-miR-139-5p JARID2 -2.11299531796557 8.16407076415038e-28 0.389563833569475 2.66930964150282e-05 miRanda -0.117957923371443 5.37316128023674e-08 NA NA NA hsa-miR-542-3p JMJD7-PLA2G4B -1.31351015149842 3.64642423288576e-22 0.293448490781786 0.00123679425607597 miRNATAP -0.122126258868508 7.88924194144572e-05 NA NA NA hsa-miR-144-3p JPH1 -2.97536914478815 6.00546047309683e-28 0.687134640890904 0.0658260491600653 miRNATAP -0.138811208984981 0.026850407670025 NA NA NA hsa-miR-3607-3p JPH1 -2.15518588554493 1.03390728226728e-23 0.687134640890904 0.0658260491600653 mirMAP -0.242979935769576 0.00240143392914074 NA NA NA hsa-miR-10b-3p KCNAB2 2.77189254628215 2.26687582932628e-20 -0.312222529644827 0.226520119820235 mirMAP -0.100754290636119 0.0197425357734666 NA NA NA hsa-miR-139-5p KCNC2 -2.11299531796557 8.16407076415038e-28 -0.473642890978533 0.27337493644138 miRanda -0.258134108506131 0.0113350326861533 NA NA NA hsa-miR-424-5p KCNJ5 -2.62653257498508 2.38997974737991e-50 1.40144080962597 1.63524689586124e-08 mirMAP -0.188888026723619 0.00219663664559687 NA NA NA hsa-miR-183-5p KCNMA1 2.33444328833177 1.52188109365421e-10 -1.61689069754613 3.52157504789145e-11 miRNATAP -0.194532008765727 1.30786594032238e-09 NA NA NA hsa-miR-675-3p KCNN3 -2.78074157259259 1.41541888062227e-14 1.31693440233029 1.88465592169231e-10 MirTarget -0.101757720501601 0.000206311872696071 NA NA NA hsa-miR-10b-3p KCNS1 2.77189254628215 2.26687582932628e-20 0.0618417850654698 0.851516908602763 MirTarget -0.115711153261506 0.0364297843096233 NA NA NA hsa-miR-424-5p KCNU1 -2.62653257498508 2.38997974737991e-50 1.87027082992174 0.000475269928317774 MirTarget -0.825391947399581 1.6236172805099e-10 NA NA NA hsa-miR-10b-3p KCTD12 2.77189254628215 2.26687582932628e-20 -0.70118053103332 3.33540431875856e-05 MirTarget -0.122502585446066 1.51054547622725e-05 NA NA NA hsa-miR-3607-3p KCTD7 -2.15518588554493 1.03390728226728e-23 1.34250062788809 1.70420639599115e-29 mirMAP;miRNATAP -0.223659350817914 2.19620597104763e-17 NA NA NA hsa-miR-139-5p KDM3A -2.11299531796557 8.16407076415038e-28 0.260290611309434 0.00489255318634796 miRanda -0.106228553255461 8.45886954159608e-07 NA NA NA hsa-miR-139-5p KDM5B -2.11299531796557 8.16407076415038e-28 0.579748004019151 7.00896705994528e-05 miRanda -0.198083267092664 6.04286441050524e-09 NA NA NA hsa-miR-149-5p KDR -0.317176971910036 0.187207559733877 -0.806222400057247 9.66990863598643e-06 miRNATAP -0.161937905853182 1.36302184666799e-05 NA NA NA hsa-miR-15a-5p KDR 0.349521211668244 0.000770735998804736 -0.806222400057247 9.66990863598643e-06 miRNATAP -0.372756033627348 1.49275800717172e-05 NA NA NA hsa-miR-15b-5p KDR 0.230566941413564 0.0824765001857479 -0.806222400057247 9.66990863598643e-06 miRNATAP -0.3391651854872 4.33957562686082e-07 NA NA NA hsa-miR-200c-3p KDR -0.104675615392797 0.716957669484981 -0.806222400057247 9.66990863598643e-06 miRNATAP -0.116520342266903 0.00016541089831424 24205206 MiR 200c increases the radiosensitivity of non small cell lung cancer cell line A549 by targeting VEGF VEGFR2 pathway; MiR-200c at the nexus of epithelial-mesenchymal transition EMT is predicted to target VEGFR2; The purpose of this study is to test the hypothesis that regulation of VEGFR2 pathway by miR-200c could modulate the radiosensitivity of cancer cells; Bioinformatic analysis luciferase reporter assays and biochemical assays were carried out to validate VEGFR2 as a direct target of miR-200c; We identified VEGFR2 as a novel target of miR-200c lung squamous cell cancer hsa-miR-338-3p KDR 0.543135607704581 0.00461167747143826 -0.806222400057247 9.66990863598643e-06 PITA;miRanda -0.124638389203913 0.00756237946861911 NA NA NA hsa-miR-455-5p KDR -0.270546034117157 0.0581320703577731 -0.806222400057247 9.66990863598643e-06 PITA;miRanda;miRNATAP -0.147638140508119 0.0192420100228486 NA NA NA hsa-miR-590-5p KDR -0.103355559980404 0.310027295317092 -0.806222400057247 9.66990863598643e-06 miRanda -0.641615310224899 1.28069025499026e-13 NA NA NA hsa-miR-618 KDR 0.13539895350352 0.517145913114103 -0.806222400057247 9.66990863598643e-06 PITA -0.135808208561215 0.00224740471076939 NA NA NA hsa-miR-139-5p KIAA0319 -2.11299531796557 8.16407076415038e-28 0.3459582477084 0.140237054651344 miRanda -0.224743009743712 4.33204013440331e-05 NA NA NA hsa-miR-3607-3p KIAA0319 -2.15518588554493 1.03390728226728e-23 0.3459582477084 0.140237054651344 mirMAP -0.113686753830964 0.02390486186139 NA NA NA hsa-miR-675-3p KIAA0513 -2.78074157259259 1.41541888062227e-14 0.677391070221105 4.5635483547066e-07 mirMAP -0.102834355914714 3.52362476054552e-09 NA NA NA hsa-miR-199a-3p KIAA0907 -2.3279328685682 1.04468066198593e-17 1.28352453441058 5.50166807221571e-31 MirTarget;PITA -0.116084175951012 9.46262912152067e-09 NA NA NA hsa-miR-199b-3p KIAA0907 -2.33226605401203 9.51887435273314e-18 1.28352453441058 5.50166807221571e-31 MirTarget;PITA -0.116151474073948 9.03836367399236e-09 NA NA NA hsa-miR-144-3p KIAA1024 -2.97536914478815 6.00546047309683e-28 0.736573717526094 0.00555757243672091 MirTarget -0.135632805009826 0.00234750987300771 NA NA NA hsa-miR-139-5p KIAA1429 -2.11299531796557 8.16407076415038e-28 0.529087998279843 4.72515528254996e-10 miRanda -0.100129854141543 6.80511625938333e-07 NA NA NA hsa-miR-139-5p KIAA1524 -2.11299531796557 8.16407076415038e-28 2.26353290817275 2.75002324721032e-22 miRanda -0.678202872317045 1.44746466906945e-37 NA NA NA hsa-miR-10b-3p KIAA1644 2.77189254628215 2.26687582932628e-20 -1.81284684066633 3.233194276281e-09 mirMAP -0.295488590608943 9.34798390757528e-09 NA NA NA hsa-miR-1269a KIAA1644 3.57543539205634 4.25369619949175e-08 -1.81284684066633 3.233194276281e-09 mirMAP -0.127952734007636 7.38782100847064e-08 NA NA NA hsa-miR-139-5p KIF15 -2.11299531796557 8.16407076415038e-28 3.46496144896513 1.75184188551877e-30 miRanda -0.92177782506768 5.34634875624422e-40 NA NA NA hsa-miR-139-5p KIF18A -2.11299531796557 8.16407076415038e-28 3.68362475076135 8.5674684516454e-42 miRanda -0.879045672225947 8.48305972485016e-43 NA NA NA hsa-miR-1269a KIF1A 3.57543539205634 4.25369619949175e-08 -0.61833871884297 0.18596206750766 mirMAP -0.110068491303298 0.0022398458682911 NA NA NA hsa-miR-139-5p KIF21B -2.11299531796557 8.16407076415038e-28 1.1784578803772 5.28752515379585e-07 mirMAP -0.238492918641919 1.89383727367712e-05 NA NA NA hsa-miR-139-5p KIF23 -2.11299531796557 8.16407076415038e-28 3.38260867585201 1.68312480021973e-36 miRanda -0.895213897222444 5.90035411766845e-48 NA NA NA hsa-miR-424-5p KIF23 -2.62653257498508 2.38997974737991e-50 3.38260867585201 1.68312480021973e-36 miRNAWalker2_validate;miRTarBase -0.44639816754639 2.27271180385325e-10 NA NA NA hsa-miR-139-5p KIF2A -2.11299531796557 8.16407076415038e-28 0.592913049515548 9.94531203466332e-07 miRanda -0.257904282288277 7.61924244489083e-21 NA NA NA hsa-miR-139-5p KIF3A -2.11299531796557 8.16407076415038e-28 0.691331553038427 1.99469350865959e-10 MirTarget;PITA;miRanda -0.117236920747142 6.13966359399872e-06 NA NA NA hsa-miR-139-5p KIN -2.11299531796557 8.16407076415038e-28 0.344953745453429 1.75711059446303e-06 miRanda -0.102931622104967 9.02320780611815e-10 NA NA NA hsa-miR-10b-3p KIRREL 2.77189254628215 2.26687582932628e-20 -0.920556464539881 0.00842298893942037 mirMAP -0.159444346689462 0.00653929855759608 NA NA NA hsa-miR-128-3p KIT 0.289735108018712 0.0114419474207889 -0.36947956147857 0.0945270050690569 MirTarget -0.342258520102763 0.000278760044005399 NA NA NA hsa-miR-130b-3p KIT 0.687190305027546 0.000109068658562255 -0.36947956147857 0.0945270050690569 miRNATAP -0.248535529800642 3.36822677046523e-05 NA NA NA hsa-miR-146b-5p KIT 0.419719546795449 0.0457375823220155 -0.36947956147857 0.0945270050690569 miRNAWalker2_validate -0.120535544137378 0.0187610976519063 NA NA NA hsa-miR-193a-3p KIT -0.117675551589896 0.309391958208578 -0.36947956147857 0.0945270050690569 MirTarget;PITA;miRanda;miRNATAP -0.332272363921644 0.000380762841679538 NA NA NA hsa-miR-193b-3p KIT -0.166697207281748 0.272022543069482 -0.36947956147857 0.0945270050690569 MirTarget;miRNATAP -0.324351670932747 4.42836626546931e-06 NA NA NA hsa-miR-19a-3p KIT 1.01712596153672 2.57753201450625e-07 -0.36947956147857 0.0945270050690569 miRTarBase;miRNATAP -0.118242386696298 0.0282424589270001 NA NA NA hsa-miR-19b-3p KIT 0.601279551368824 0.00016685097085251 -0.36947956147857 0.0945270050690569 miRNATAP -0.141362307947708 0.035544991242993 NA NA NA hsa-miR-20a-5p KIT 0.854326758727003 5.04256669663285e-07 -0.36947956147857 0.0945270050690569 miRTarBase -0.225765388624807 0.000296472897214121 NA NA NA hsa-miR-34a-5p KIT 1.03694231790865 5.74864019540594e-14 -0.36947956147857 0.0945270050690569 MirTarget -0.159543555669109 0.0358933176735168 NA NA NA hsa-miR-192-3p KITLG -0.6401165114007 0.000266272092403814 0.795506881904605 2.04054574930174e-05 mirMAP -0.295004448161722 8.59654669637728e-09 NA NA NA hsa-miR-23b-3p KITLG -0.530561587109023 5.43807206823652e-07 0.795506881904605 2.04054574930174e-05 mirMAP -0.348544188357782 4.92671720566124e-05 NA NA NA hsa-miR-26b-5p KITLG -1.10804856399744 4.14176110314282e-22 0.795506881904605 2.04054574930174e-05 mirMAP -0.234810293820746 0.00211032519308696 NA NA NA hsa-miR-30b-5p KITLG -0.54056186708617 2.44688760798341e-05 0.795506881904605 2.04054574930174e-05 mirMAP -0.16449999136192 0.0213982425666408 NA NA NA hsa-miR-30d-3p KITLG -0.120562286038759 0.329549534782125 0.795506881904605 2.04054574930174e-05 MirTarget -0.150648157338652 0.0443686292176647 NA NA NA hsa-miR-33a-3p KITLG -0.683025859637737 1.01106097756419e-05 0.795506881904605 2.04054574930174e-05 mirMAP -0.224106371999546 0.00013598203009133 NA NA NA hsa-miR-345-5p KITLG -0.712725883885838 3.60393522979373e-06 0.795506881904605 2.04054574930174e-05 MirTarget -0.156313293057969 0.00827560779339111 NA NA NA hsa-miR-139-5p KLC2 -2.11299531796557 8.16407076415038e-28 1.16492926016379 3.19134150923749e-23 miRanda;miRNATAP -0.274756618912985 3.23139540935568e-23 NA NA NA hsa-miR-424-5p KLC2 -2.62653257498508 2.38997974737991e-50 1.16492926016379 3.19134150923749e-23 miRNATAP -0.109712047255076 0.000279583206424304 NA NA NA hsa-miR-424-5p KLF13 -2.62653257498508 2.38997974737991e-50 1.11571195583237 1.69897534012305e-15 mirMAP -0.191963089405438 4.14648963082819e-08 NA NA NA hsa-miR-10b-5p KLF4 2.86931593037303 6.97409423207806e-23 -1.65022485340468 8.09789885316327e-13 miRNAWalker2_validate;miRTarBase;miRNATAP -0.111547287482004 0.00291202753703097 26191201;25428807;27764757;24216130;20075075;24573354;25063061 Augmented miR 10b expression associated with depressed expression of its target gene KLF4 involved in gastric carcinoma; In this study we aimed to assess whether Krüppel-like factor 4 KLF4 is a target gene of miR-10b in gastric cancer GC; Targeting of KLF4 by miR-10b was confirmed by dual-luciferase reporter assays; The expression levels of miR-10b and KLF4 mRNA in 5 different gastric cancer cell lines and 65 pairs of gastric cancer tissues were detected by Real-time PCR; KLF4 is a direct target gene of miR-10b in GC and its expression is reduced by miR-10b at both mRNA and protein levels; In addition the expression level of miR-10b was tendentiously upregulated in GC tissues while the expression levels of KLF4 mRNA and protein were decreased in gastric cancer tissues compared with normal adjacent tissue; There was a dramatically inverse correlation between the expression levels of miR-10b and KLF4 mRNA in GC r=-0.339 P=0.006; These findings indicate that miR-10b was upregulated in GC and may have a key role in GC pathogenesis and development through the downregulation of its target gene KLF4;Moreover upon uptake miR-10b can suppress the protein level of its target genes such as HOXD10 and KLF4 indicating its functional significance;miR 10b promotes invasion by targeting KLF4 in osteosarcoma cells; The relationship between miR-10b and KLF4 was evaluated using dual-luciferase assay correlation analysis; miR-10b is overexpressed in osteosarcoma and KLF4 is the direct target gene of miR-10b; Furthermore miR-10b promotes osteosarcoma cells progression by downregulating KLF4 expression;Krüppel-like factor 4 KLF4 may be indirectly targeted by miR-10b during the proliferation increasing of A549 cells;MicroRNA 10b promotes migration and invasion through KLF4 in human esophageal cancer cell lines; Additionally we identified KLF4 a known tumor suppressor gene that has been reported to suppress esophageal cancer cell migration and invasion as a direct target of miR-10b; Furthermore overexpression of miR-10b in KYSE140 and KYSE450 cells led to a reduction of endogenous KLF4 protein whereas silencing of miR-10b in EC9706 cells caused up-regulation of KLF4 protein; Coexpression of miR-10b and KLF4 in KYSE140 cells and coexpression of small interfering RNA for KLF4 mRNA and miR-10b-AS in EC9706 cells partially abrogated the effect of miR-10b on cell migration and invasion;MicroRNA 10b promotes migration and invasion through KLF4 and HOXD10 in human bladder cancer; Luciferase assays were also performed to validate KLF4 and HOXD10 as miR-10b targets; Moreover KLF4 and HOXD10 were identified as direct targets of miR-10b in BC cells;MicroRNA-10b may promote proliferation and invasion of 95-C cells by down regulating the expression of KLF4 protein ;;progression;;cell migration;; gastric cancer;breast cancer;sarcoma;lung squamous cell cancer;esophageal cancer;bladder cancer;lung cancer hsa-miR-10b-3p KLF6 2.77189254628215 2.26687582932628e-20 -1.43852959018658 4.46638206050043e-20 mirMAP -0.142912832283543 1.43326067868707e-07 NA NA NA hsa-miR-10b-3p KLF7 2.77189254628215 2.26687582932628e-20 -1.04701042856457 5.35024579653903e-05 MirTarget -0.118246137423964 0.00684446786671976 NA NA NA hsa-miR-424-5p KLHDC8B -2.62653257498508 2.38997974737991e-50 0.524333646266656 6.20608833052194e-05 MirTarget -0.132832773588239 3.37691664402582e-05 NA NA NA hsa-miR-424-5p KLHL21 -2.62653257498508 2.38997974737991e-50 0.640094972752153 4.1563221568273e-06 mirMAP -0.190348642296912 1.86263696883094e-08 NA NA NA hsa-miR-10b-3p KLHL3 2.77189254628215 2.26687582932628e-20 -0.82550240612119 0.00204726487055326 mirMAP -0.153647671194615 0.000616287776112484 NA NA NA hsa-miR-139-5p KLHL31 -2.11299531796557 8.16407076415038e-28 1.26597140369387 1.58519014245934e-11 miRanda -0.191394528234448 2.20153170958683e-05 NA NA NA hsa-miR-224-5p KLK10 2.67175249172213 1.46995328399796e-18 -3.27046406318718 3.8199466026554e-21 miRNAWalker2_validate;miRTarBase -0.240732258692195 1.45336032444254e-05 20354523 When we co-transfected cells with pMIR-KLK10 and either let-7f miR-224 or mR-516a we saw decreased luciferase signal suggesting that these miRNAs can target KLK10 ovarian cancer hsa-miR-183-5p KLRD1 2.33444328833177 1.52188109365421e-10 -1.83144193603113 1.51189909857633e-14 MirTarget -0.125164554906499 9.08851676205924e-05 NA NA NA hsa-miR-139-5p KPNA2 -2.11299531796557 8.16407076415038e-28 1.3966720979923 7.12247839063516e-25 miRanda -0.404531341599787 2.49752326660711e-39 NA NA NA hsa-miR-144-3p KPNA2 -2.97536914478815 6.00546047309683e-28 1.3966720979923 7.12247839063516e-25 MirTarget -0.130581010114206 3.96964688611583e-08 NA NA NA hsa-miR-140-3p KRAS 0.546012239205329 4.84578261098777e-11 -0.338081744192936 0.00043842779003105 MirTarget -0.247198429138234 9.22756583574077e-06 NA NA NA hsa-miR-16-1-3p KRAS 0.392360028038559 0.00112481918108198 -0.338081744192936 0.00043842779003105 mirMAP -0.114704330599848 0.00330327136149234 NA NA NA hsa-miR-193a-3p KRAS -0.117675551589896 0.309391958208578 -0.338081744192936 0.00043842779003105 MirTarget;miRanda;miRNATAP -0.128182356310374 0.00170700856743147 NA NA NA hsa-miR-193b-3p KRAS -0.166697207281748 0.272022543069482 -0.338081744192936 0.00043842779003105 miRNAWalker2_validate;MirTarget;miRNATAP -0.120510531869791 9.78248377856047e-05 25905463 Deregulation of the MiR 193b KRAS Axis Contributes to Impaired Cell Growth in Pancreatic Cancer; Mechanistically KRAS was verified as a direct effector of miR-193b through which the AKT and ERK pathways were modulated and cell growth of PDAC cells was suppressed; Taken together our findings indicate that miR-193b-mediated deregulation of the KRAS axis is involved in pancreatic carcinogenesis and suggest that miR-193b could be a potentially effective target for PDAC therapy tumorigenesis pancreatic cancer hsa-miR-30d-3p KRAS -0.120562286038759 0.329549534782125 -0.338081744192936 0.00043842779003105 MirTarget;miRNATAP -0.132565215112955 0.000512493362671086 NA NA NA hsa-miR-532-5p KRAS 1.02729546510601 9.93318913966636e-16 -0.338081744192936 0.00043842779003105 MirTarget;PITA;miRNATAP -0.137739612561571 0.000100604507963156 NA NA NA hsa-miR-1269a KRT80 3.57543539205634 4.25369619949175e-08 -1.78330372707111 1.41618233654198e-05 mirMAP -0.130508265541675 4.10789184924498e-05 NA NA NA hsa-miR-125b-2-3p KSR1 -1.6609436107315 5.71534047969855e-18 0.642891251299799 3.57442067630892e-06 mirMAP -0.135355535403742 6.63930676543279e-05 NA NA NA hsa-miR-125b-5p KSR1 -1.35767721102906 1.16564617395164e-18 0.642891251299799 3.57442067630892e-06 mirMAP -0.135700306308622 0.00139838284757057 NA NA NA hsa-miR-130b-5p KSR1 0.170599813152408 0.337611586432771 0.642891251299799 3.57442067630892e-06 mirMAP -0.104935212494022 0.00637725895382792 NA NA NA hsa-miR-194-3p KSR1 -0.772747277805343 2.9537465170191e-05 0.642891251299799 3.57442067630892e-06 mirMAP -0.26971890007079 3.27211697024294e-14 NA NA NA hsa-miR-28-5p KSR1 -0.430964830599964 2.67367257252925e-06 0.642891251299799 3.57442067630892e-06 miRanda -0.430684983080331 4.23624958240357e-09 NA NA NA hsa-miR-30c-5p KSR1 -0.432111642767632 0.000159764714931007 0.642891251299799 3.57442067630892e-06 MirTarget -0.141642578918507 0.0177701611380028 NA NA NA hsa-miR-30e-5p KSR1 -0.627815042856657 3.02205690184908e-10 0.642891251299799 3.57442067630892e-06 MirTarget -0.281376496008921 2.91224385327695e-05 NA NA NA hsa-miR-33a-5p KSR1 -0.767474460958522 1.09948756118522e-05 0.642891251299799 3.57442067630892e-06 mirMAP -0.104706788438559 0.00694939023055989 NA NA NA hsa-miR-33b-5p KSR1 -2.28852395459234 2.69046626645242e-22 0.642891251299799 3.57442067630892e-06 mirMAP -0.156750165730437 8.62296661180586e-09 NA NA NA hsa-miR-3607-3p KSR1 -2.15518588554493 1.03390728226728e-23 0.642891251299799 3.57442067630892e-06 mirMAP -0.147388990725264 7.10559770012909e-07 NA NA NA hsa-miR-378c KSR1 -1.54028191929038 2.70131554214866e-15 0.642891251299799 3.57442067630892e-06 miRNATAP -0.228306835622337 4.87739640617492e-12 NA NA NA hsa-miR-455-5p KSR1 -0.270546034117157 0.0581320703577731 0.642891251299799 3.57442067630892e-06 miRanda -0.142020753420233 0.00304759572991457 NA NA NA hsa-miR-590-3p KSR1 -0.473167498047808 1.76652934637227e-05 0.642891251299799 3.57442067630892e-06 mirMAP -0.137947811620825 0.0260000353451378 NA NA NA hsa-miR-101-3p KSR2 -1.48176407980989 3.98950707385704e-31 0.506902986173332 0.110760452022147 mirMAP -0.451733791944941 5.77709491523009e-05 NA NA NA hsa-miR-122-5p KSR2 -1.23907441373955 4.42181244888642e-06 0.506902986173332 0.110760452022147 mirMAP -0.272913408779166 1.18304533776478e-06 NA NA NA hsa-miR-125b-2-3p KSR2 -1.6609436107315 5.71534047969855e-18 0.506902986173332 0.110760452022147 mirMAP -0.221746368549375 0.00415082708481942 NA NA NA hsa-miR-126-5p KSR2 -0.428561469405594 6.6035585844222e-05 0.506902986173332 0.110760452022147 mirMAP -0.384511650519239 0.00776399829726944 NA NA NA hsa-miR-139-5p KSR2 -2.11299531796557 8.16407076415038e-28 0.506902986173332 0.110760452022147 mirMAP -0.341099505972807 4.44812560849743e-06 NA NA NA hsa-miR-148a-3p KSR2 -0.748702855596996 3.93313343865641e-07 0.506902986173332 0.110760452022147 mirMAP -0.476743808874194 3.69345752464517e-06 NA NA NA hsa-miR-148a-5p KSR2 -0.767626696027761 1.08359477494797e-06 0.506902986173332 0.110760452022147 mirMAP -0.348470380741742 0.000333111282548724 NA NA NA hsa-miR-192-5p KSR2 -0.50188499512787 0.00344713341196035 0.506902986173332 0.110760452022147 mirMAP -0.33303441995803 0.000208002549007142 NA NA NA hsa-miR-193b-5p KSR2 -0.748481053559202 3.37008423124215e-06 0.506902986173332 0.110760452022147 mirMAP -0.319703819484779 0.000775994652976958 NA NA NA hsa-miR-194-3p KSR2 -0.772747277805343 2.9537465170191e-05 0.506902986173332 0.110760452022147 mirMAP -0.214377473589887 0.00992561749486391 NA NA NA hsa-miR-194-5p KSR2 -0.292530160992458 0.0996141384876663 0.506902986173332 0.110760452022147 mirMAP -0.33828430678493 9.97782396172317e-05 NA NA NA hsa-miR-29a-3p KSR2 -0.856762511178136 4.65330336378459e-12 0.506902986173332 0.110760452022147 mirMAP -0.376380206618752 0.00209171188646652 NA NA NA hsa-miR-29c-3p KSR2 -1.4367517608807 1.61767774905781e-21 0.506902986173332 0.110760452022147 mirMAP -0.290914822982681 0.00292330288589756 NA NA NA hsa-miR-30b-3p KSR2 -0.439724365151373 0.000947180503583586 0.506902986173332 0.110760452022147 mirMAP -0.319474957995962 0.00608378815187026 NA NA NA hsa-miR-30e-5p KSR2 -0.627815042856657 3.02205690184908e-10 0.506902986173332 0.110760452022147 mirMAP -0.406039884871926 0.0082508804785254 NA NA NA hsa-miR-32-5p KSR2 0.0806126674664016 0.548984992497432 0.506902986173332 0.110760452022147 miRNATAP -0.33886728080016 0.00343125881517266 NA NA NA hsa-miR-3607-3p KSR2 -2.15518588554493 1.03390728226728e-23 0.506902986173332 0.110760452022147 mirMAP -0.165850424907764 0.0150366828495642 NA NA NA hsa-miR-378a-5p KSR2 -1.58667444700188 3.19640857320504e-17 0.506902986173332 0.110760452022147 mirMAP -0.16923292930987 0.0329636314696005 NA NA NA hsa-miR-548b-3p KSR2 -0.0203576084717134 0.930819503166956 0.506902986173332 0.110760452022147 mirMAP -0.165535419924569 0.0136471658373127 NA NA NA hsa-miR-618 KSR2 0.13539895350352 0.517145913114103 0.506902986173332 0.110760452022147 mirMAP -0.232916342723512 0.00242748807992429 NA NA NA hsa-miR-99a-3p KSR2 -1.58675677435223 6.52225550697449e-15 0.506902986173332 0.110760452022147 mirMAP -0.158793019835659 0.03181761736651 NA NA NA hsa-miR-224-5p L1CAM 2.67175249172213 1.46995328399796e-18 -2.17662202578555 7.98640023815695e-13 MirTarget -0.1122638479823 0.0193894584599879 NA NA NA hsa-miR-139-5p LAGE3 -2.11299531796557 8.16407076415038e-28 0.964888860429346 1.5009034148606e-11 miRanda -0.249936626009725 9.54487940633343e-14 NA NA NA hsa-miR-139-5p LAMC1 -2.11299531796557 8.16407076415038e-28 1.18164580989765 3.65525462453826e-17 miRanda -0.226258385144221 1.69064747798937e-11 NA NA NA hsa-miR-424-5p LAMC1 -2.62653257498508 2.38997974737991e-50 1.18164580989765 3.65525462453826e-17 MirTarget;miRNATAP -0.164700621655061 3.21163281537882e-06 NA NA NA hsa-miR-139-5p LAPTM4B -2.11299531796557 8.16407076415038e-28 1.07428089690096 5.86976228026329e-07 miRanda -0.391981985321356 3.17113302953593e-15 NA NA NA hsa-miR-139-5p LARP4B -2.11299531796557 8.16407076415038e-28 0.424958931309075 1.60883657990558e-10 miRanda -0.137475774090448 1.69549629436418e-19 NA NA NA hsa-miR-139-3p LASP1 -2.53151940925585 1.56777509736867e-36 0.523794786889897 6.87898834597451e-10 mirMAP -0.155020208357061 4.78353762388254e-17 NA NA NA hsa-miR-10b-3p LDOC1L 2.77189254628215 2.26687582932628e-20 -0.661168203841977 0.000563897974207453 mirMAP -0.115518888996649 0.000325191950811624 NA NA NA hsa-miR-139-5p LENG8 -2.11299531796557 8.16407076415038e-28 0.75934588482606 9.40854812638038e-12 miRanda -0.113218058355104 2.26626381651474e-05 NA NA NA hsa-miR-424-5p LENG8 -2.62653257498508 2.38997974737991e-50 0.75934588482606 9.40854812638038e-12 mirMAP -0.128711053522361 3.2722247711644e-06 NA NA NA hsa-miR-224-5p LEPROT 2.67175249172213 1.46995328399796e-18 -0.766289999290305 0.00143475208504872 mirMAP -0.128704654078753 0.000488816766845374 NA NA NA hsa-miR-139-5p LGI4 -2.11299531796557 8.16407076415038e-28 0.0146526815342609 0.948022752191612 miRanda -0.118310644626304 0.0255033108588923 NA NA NA hsa-miR-139-5p LIG3 -2.11299531796557 8.16407076415038e-28 0.616420814558472 9.14643546527433e-15 miRanda -0.123592201385723 6.11282101417861e-11 NA NA NA hsa-miR-199a-3p LIN28B -2.3279328685682 1.04468066198593e-17 2.26854994708754 4.69141976850235e-05 MirTarget;PITA;miRNATAP -0.393372531756874 4.26654626214358e-05 NA NA NA hsa-miR-199b-3p LIN28B -2.33226605401203 9.51887435273314e-18 2.26854994708754 4.69141976850235e-05 MirTarget;PITA;miRNATAP -0.393545543127955 4.17829704077677e-05 NA NA NA hsa-miR-3607-3p LIN28B -2.15518588554493 1.03390728226728e-23 2.26854994708754 4.69141976850235e-05 MirTarget;miRNATAP -0.321921427748174 0.00757107760374481 NA NA NA hsa-miR-139-5p LIN9 -2.11299531796557 8.16407076415038e-28 1.53758985014096 2.9412533171642e-23 miRanda -0.33678726997168 6.56417679504967e-20 NA NA NA hsa-miR-139-5p LLGL1 -2.11299531796557 8.16407076415038e-28 0.947565653523109 2.51534195296859e-14 miRNATAP -0.216974577338777 1.5789148033507e-13 NA NA NA hsa-miR-424-5p LMNB2 -2.62653257498508 2.38997974737991e-50 1.15533579106848 2.8635849155846e-19 mirMAP -0.143491396946239 1.12700005429612e-05 NA NA NA hsa-miR-139-3p LMTK3 -2.53151940925585 1.56777509736867e-36 0.0460938408884213 0.907824476359942 miRNATAP -0.207267008163329 0.0190623383709437 NA NA NA hsa-miR-10b-3p LONRF2 2.77189254628215 2.26687582932628e-20 -1.03606777199417 0.00951581549876641 mirMAP -0.181768250707284 0.00670700932403372 NA NA NA hsa-miR-224-5p LONRF2 2.67175249172213 1.46995328399796e-18 -1.03606777199417 0.00951581549876641 mirMAP -0.139163722583068 0.023668886486137 NA NA NA hsa-miR-139-5p LPCAT1 -2.11299531796557 8.16407076415038e-28 0.979301235361667 4.14787419947705e-08 miRanda -0.462725552744635 1.90864554714278e-31 NA NA NA hsa-miR-139-5p LPGAT1 -2.11299531796557 8.16407076415038e-28 0.635448072301032 7.01404383798336e-07 PITA;mirMAP -0.161770503986855 8.09077158095454e-08 NA NA NA hsa-miR-139-5p LRP12 -2.11299531796557 8.16407076415038e-28 0.456838554349231 0.0312242549766872 MirTarget;PITA;miRanda -0.241836423570854 1.05600038084572e-06 NA NA NA hsa-miR-3607-3p LRP8 -2.15518588554493 1.03390728226728e-23 0.86386782073676 0.000478944145486285 MirTarget;miRNATAP -0.171341479965797 0.00128830326282232 NA NA NA hsa-miR-144-3p LRRC14 -2.97536914478815 6.00546047309683e-28 1.36580119828543 4.14163388274102e-35 mirMAP -0.141736370108096 4.99132420387442e-13 NA NA NA hsa-miR-424-5p LRRC14 -2.62653257498508 2.38997974737991e-50 1.36580119828543 4.14163388274102e-35 mirMAP -0.321937157889452 2.92992856992256e-32 NA NA NA hsa-miR-424-5p LRRC20 -2.62653257498508 2.38997974737991e-50 0.592111730852268 3.14506509222137e-05 mirMAP -0.227657764781202 3.16122545988556e-11 NA NA NA hsa-miR-139-5p LRRC37A2 -2.11299531796557 8.16407076415038e-28 0.701371702727413 3.05377841809045e-05 miRanda -0.142369417694585 0.000352717419483667 NA NA NA hsa-miR-139-5p LRRC8B -2.11299531796557 8.16407076415038e-28 -0.654336651065766 0.000402530838893617 miRanda -0.12095595075455 0.00577391148555656 NA NA NA hsa-miR-199a-3p LRRC8D -2.3279328685682 1.04468066198593e-17 0.302080319292119 0.000965409775769997 miRNATAP -0.101046546874851 5.69640058771728e-11 NA NA NA hsa-miR-424-5p LSM11 -2.62653257498508 2.38997974737991e-50 0.758646663868328 2.93737544855881e-13 MirTarget -0.182532754659576 7.40395341231483e-13 NA NA NA hsa-miR-139-5p LSM14B -2.11299531796557 8.16407076415038e-28 0.435904204745383 1.7100051386832e-07 miRanda -0.104093452655935 1.09946971632957e-07 NA NA NA hsa-miR-139-5p LTA -2.11299531796557 8.16407076415038e-28 0.541951284853821 0.0223951539504111 miRanda -0.250291588122767 6.72672627069048e-06 NA NA NA hsa-miR-424-5p LYPLAL1 -2.62653257498508 2.38997974737991e-50 0.334284012812255 0.00426402531538069 MirTarget -0.162055394677762 9.14445104209683e-09 NA NA NA hsa-miR-424-5p LZTR1 -2.62653257498508 2.38997974737991e-50 0.512029352084425 3.06806864052276e-12 mirMAP -0.111264488186776 6.41807053519963e-10 NA NA NA hsa-miR-139-5p LZTS2 -2.11299531796557 8.16407076415038e-28 0.780214963527083 2.01411538988928e-11 miRanda -0.186325681444322 1.09588047849915e-11 NA NA NA hsa-miR-139-5p MAD2L1 -2.11299531796557 8.16407076415038e-28 2.12271197949055 2.5877373631959e-30 miRanda -0.59204072876179 1.2497576446289e-44 NA NA NA hsa-miR-139-5p MAEL -2.11299531796557 8.16407076415038e-28 1.3003011503469 0.00169474687395575 miRanda -0.397822225463675 4.54595691938246e-05 NA NA NA hsa-miR-424-5p MAFG -2.62653257498508 2.38997974737991e-50 1.20304222370093 2.42633916447559e-19 mirMAP -0.222128061354665 3.22615604549884e-11 NA NA NA hsa-miR-139-5p MAGEC1 -2.11299531796557 8.16407076415038e-28 2.68285498456523 7.45284600531983e-06 miRanda -0.405563929382662 0.00446227774483858 NA NA NA hsa-miR-3607-3p MAMLD1 -2.15518588554493 1.03390728226728e-23 -0.104121905235914 0.65300085375544 mirMAP -0.192840687792178 9.27633684123212e-05 NA NA NA hsa-miR-424-5p MAMSTR -2.62653257498508 2.38997974737991e-50 1.83212439467961 8.29084371980825e-18 MirTarget;miRNATAP -0.328034684418449 7.94167899327943e-10 NA NA NA hsa-miR-3607-3p MAP1B -2.15518588554493 1.03390728226728e-23 0.751522072716614 1.33167615372873e-05 mirMAP;miRNATAP -0.100059530676142 0.00736258251752347 NA NA NA hsa-miR-139-5p MAP2 -2.11299531796557 8.16407076415038e-28 1.05154488256307 5.66592949255683e-05 MirTarget;PITA;miRanda -0.192973520421388 0.00184839311405067 NA NA NA hsa-miR-483-3p MAP2 -2.99328900859484 2.67538108509603e-07 1.05154488256307 5.66592949255683e-05 PITA;miRNATAP -0.170319128238088 8.49208451265459e-16 NA NA NA hsa-miR-140-3p MAP2K1 0.546012239205329 4.84578261098777e-11 -1.22814648702538 4.27448032410174e-41 PITA -0.381987666476187 3.26697824928144e-11 NA NA NA hsa-miR-34a-5p MAP2K1 1.03694231790865 5.74864019540594e-14 -1.22814648702538 4.27448032410174e-41 miRNAWalker2_validate;miRTarBase -0.229470281840033 1.32655977381036e-11 NA NA NA hsa-miR-361-5p MAP2K1 0.233202959858696 0.00961572812255327 -1.22814648702538 4.27448032410174e-41 miRanda -0.180575442044722 0.00107072926955335 NA NA NA hsa-miR-501-5p MAP2K1 1.15231083477882 2.98906150004088e-10 -1.22814648702538 4.27448032410174e-41 PITA -0.144135390798289 3.07397683406163e-08 NA NA NA hsa-let-7b-5p MAP2K2 -0.959013717270803 5.95127281258643e-11 0.626002935787801 2.22116323165311e-10 miRNAWalker2_validate -0.179048006528372 3.03569472992354e-08 NA NA NA hsa-miR-139-5p MAP3K1 -2.11299531796557 8.16407076415038e-28 0.0159561891588775 0.877325572084852 miRanda -0.113087719069936 2.56009314429985e-06 NA NA NA hsa-miR-139-5p MAP7D1 -2.11299531796557 8.16407076415038e-28 0.448704907787342 1.77667890542935e-06 miRanda -0.147296595695543 1.49401961869787e-11 NA NA NA hsa-miR-130b-3p MAPK10 0.687190305027546 0.000109068658562255 -1.09210524801043 3.20431274629696e-05 miRNATAP -0.246373643413876 0.000632339067040355 NA NA NA hsa-miR-146b-5p MAPK10 0.419719546795449 0.0457375823220155 -1.09210524801043 3.20431274629696e-05 miRanda -0.252372073662625 3.58793936262133e-05 NA NA NA hsa-miR-19a-3p MAPK10 1.01712596153672 2.57753201450625e-07 -1.09210524801043 3.20431274629696e-05 miRNATAP -0.168630672973342 0.00898420702556428 NA NA NA hsa-miR-19b-3p MAPK10 0.601279551368824 0.00016685097085251 -1.09210524801043 3.20431274629696e-05 miRNATAP -0.202245351611927 0.0120351860236733 NA NA NA hsa-miR-221-3p MAPK10 1.12244756358612 3.48370308238012e-13 -1.09210524801043 3.20431274629696e-05 miRNATAP -0.345546531666561 1.95748420882985e-05 NA NA NA hsa-miR-222-3p MAPK10 1.08574156066353 1.76407192348131e-11 -1.09210524801043 3.20431274629696e-05 miRNATAP -0.215253828844877 0.00588066987412212 NA NA NA hsa-miR-454-3p MAPK10 0.668749059573955 2.42670710515113e-06 -1.09210524801043 3.20431274629696e-05 miRNATAP -0.19018890919728 0.0355512111583229 NA NA NA hsa-miR-455-5p MAPK10 -0.270546034117157 0.0581320703577731 -1.09210524801043 3.20431274629696e-05 miRanda -0.235174401855498 0.00956735979323835 NA NA NA hsa-miR-590-5p MAPK10 -0.103355559980404 0.310027295317092 -1.09210524801043 3.20431274629696e-05 PITA;miRanda;miRNATAP -0.3693102549963 0.00397298728893767 NA NA NA hsa-miR-30b-5p MAPK8 -0.54056186708617 2.44688760798341e-05 -0.855423391564126 4.38860774117184e-05 mirMAP -0.211224878227047 0.0083058660521866 NA NA NA hsa-miR-30d-5p MAPK8 0.718283816348023 2.47422074061352e-08 -0.855423391564126 4.38860774117184e-05 mirMAP -0.215078369558139 0.00642208423108097 NA NA NA hsa-miR-424-5p MAPK8IP2 -2.62653257498508 2.38997974737991e-50 2.63392070012632 1.02369935409566e-14 mirMAP -0.37967583784219 8.9905499499638e-06 NA NA NA hsa-miR-140-5p MAPK9 -0.220106443070144 0.0140713197101242 0.23378807508407 0.00112433159060846 miRanda -0.130430637695707 0.000917008693159836 NA NA NA hsa-miR-590-3p MAPK9 -0.473167498047808 1.76652934637227e-05 0.23378807508407 0.00112433159060846 miRanda;mirMAP -0.101280114384897 0.00134322482300103 NA NA NA hsa-miR-139-5p MAPRE1 -2.11299531796557 8.16407076415038e-28 0.332650746770886 0.000501958694685901 miRanda -0.1936179541659 3.57532414685118e-19 NA NA NA hsa-miR-144-3p MARCH3 -2.97536914478815 6.00546047309683e-28 0.616348863709913 0.0025556726558054 MirTarget -0.141896424986677 3.23756221519159e-05 NA NA NA hsa-miR-139-5p MARCKSL1 -2.11299531796557 8.16407076415038e-28 0.308949751259346 0.0647399541617895 miRanda -0.238614417614977 7.04858297541212e-10 NA NA NA hsa-miR-3607-3p MARK1 -2.15518588554493 1.03390728226728e-23 0.0714268590059156 0.762956488431703 miRNATAP -0.116357087555612 0.021868153635229 NA NA NA hsa-miR-10b-3p MARVELD3 2.77189254628215 2.26687582932628e-20 -0.124533314880338 0.510314368687358 mirMAP -0.133071029483533 2.25091946439305e-05 NA NA NA hsa-miR-3607-3p MAST3 -2.15518588554493 1.03390728226728e-23 1.00050372593965 3.02782985825781e-19 miRNATAP -0.145503915871625 3.19211031376887e-09 NA NA NA hsa-miR-139-5p MASTL -2.11299531796557 8.16407076415038e-28 0.568776775489586 1.11123138787736e-07 miRanda -0.140491645249578 2.54547101243441e-08 NA NA NA hsa-miR-10b-3p MBNL2 2.77189254628215 2.26687582932628e-20 -1.32208886120192 1.96175870553543e-18 miRNATAP -0.149398798484539 8.5950858620828e-09 NA NA NA hsa-miR-224-5p MBNL2 2.67175249172213 1.46995328399796e-18 -1.32208886120192 1.96175870553543e-18 MirTarget -0.138340775072585 5.86872525547001e-09 NA NA NA hsa-miR-224-5p MCC 2.67175249172213 1.46995328399796e-18 -2.36915505634884 5.46995786737825e-22 mirMAP -0.194150454976153 7.93846533562871e-07 NA NA NA hsa-miR-3607-3p MCF2L2 -2.15518588554493 1.03390728226728e-23 1.48223798220475 1.05240457208762e-05 MirTarget -0.251190542824455 0.000545990314158937 NA NA NA hsa-miR-139-5p MCM2 -2.11299531796557 8.16407076415038e-28 2.386213124759 2.3135357405317e-32 miRanda -0.60342281675185 7.72277609982919e-38 NA NA NA hsa-miR-139-3p MCRS1 -2.53151940925585 1.56777509736867e-36 0.805888924909901 1.08778707907431e-26 miRNATAP -0.218127827493829 4.08174929197489e-42 NA NA NA hsa-miR-33b-5p MDGA1 -2.28852395459234 2.69046626645242e-22 1.09023577522186 0.00025808585973707 mirMAP -0.273476436108839 3.2806028179809e-06 NA NA NA hsa-miR-139-5p MDGA2 -2.11299531796557 8.16407076415038e-28 0.095338851975197 0.824518766363714 miRanda -0.198934985867263 0.0498823111890125 NA NA NA hsa-miR-199a-3p MDGA2 -2.3279328685682 1.04468066198593e-17 0.095338851975197 0.824518766363714 MirTarget;miRNATAP -0.159219934803811 0.0313286550086669 NA NA NA hsa-miR-199b-3p MDGA2 -2.33226605401203 9.51887435273314e-18 0.095338851975197 0.824518766363714 MirTarget;miRNATAP -0.159557468978344 0.0308483511846025 NA NA NA hsa-miR-144-3p MDM4 -2.97536914478815 6.00546047309683e-28 0.73357660128009 1.75853291398166e-12 miRNATAP -0.107660843247821 8.50061365782608e-10 NA NA NA hsa-miR-33b-5p MDM4 -2.28852395459234 2.69046626645242e-22 0.73357660128009 1.75853291398166e-12 MirTarget -0.112686308994984 5.88126336967115e-08 NA NA NA hsa-miR-3607-3p MDM4 -2.15518588554493 1.03390728226728e-23 0.73357660128009 1.75853291398166e-12 mirMAP -0.129449974145506 9.01215783136111e-09 NA NA NA hsa-miR-424-5p MDM4 -2.62653257498508 2.38997974737991e-50 0.73357660128009 1.75853291398166e-12 mirMAP -0.145693791571925 1.44293880173031e-08 NA NA NA hsa-miR-424-5p MED22 -2.62653257498508 2.38997974737991e-50 0.901475361439055 2.19971977737607e-20 mirMAP -0.165766318396824 1.03485038738756e-11 NA NA NA hsa-miR-139-5p MEIS2 -2.11299531796557 8.16407076415038e-28 0.156457406703811 0.32841086989024 MirTarget;PITA;miRanda;miRNATAP -0.112997566158335 0.00267308309259549 NA NA NA hsa-miR-424-5p MEOX2 -2.62653257498508 2.38997974737991e-50 1.3378919040585 2.13602029063847e-06 MirTarget -0.31182044914101 6.84492939481122e-06 NA NA NA hsa-miR-125a-3p MET -0.841683158494395 3.51202687176603e-05 -0.153206483336303 0.252348462860111 miRanda -0.156151209622555 1.20437354901061e-06 NA NA NA hsa-miR-130a-3p MET -1.53229181736223 2.91460363624872e-19 -0.153206483336303 0.252348462860111 miRNAWalker2_validate -0.174282381687757 1.40093229108985e-06 NA NA NA hsa-miR-324-5p MET 0.372933276649782 0.00592280066108904 -0.153206483336303 0.252348462860111 miRanda -0.265570825799172 2.14440923054991e-08 NA NA NA hsa-miR-362-3p MET 0.814007335895913 2.00108618836568e-09 -0.153206483336303 0.252348462860111 miRanda -0.144789460757098 0.00214250548628117 NA NA NA hsa-miR-421 MET 0.941856334694081 6.12167297054077e-08 -0.153206483336303 0.252348462860111 miRanda -0.12059316211551 0.00110497994976015 NA NA NA hsa-miR-532-3p MET 0.297601533259956 0.014632205884815 -0.153206483336303 0.252348462860111 PITA -0.128181076998522 0.016944928133747 NA NA NA hsa-miR-139-3p METTL2A -2.53151940925585 1.56777509736867e-36 0.389342567604536 3.05948897211101e-07 MirTarget -0.103295054166328 6.51761361416506e-10 NA NA NA hsa-miR-139-5p MEX3A -2.11299531796557 8.16407076415038e-28 1.40487967567447 8.53457810346479e-13 PITA;miRanda;miRNATAP -0.402098861841986 1.3913052287526e-18 NA NA NA hsa-miR-3607-3p MEX3D -2.15518588554493 1.03390728226728e-23 0.404132139619263 0.000424748861780902 mirMAP;miRNATAP -0.128316975531956 1.4057651567231e-07 NA NA NA hsa-miR-483-3p MFAP3L -2.99328900859484 2.67538108509603e-07 -2.99511248620354 4.97173912475439e-19 MirTarget;PITA -0.103359411542776 0.000392099168063992 NA NA NA hsa-miR-139-5p MFSD6 -2.11299531796557 8.16407076415038e-28 0.933089163217582 1.03773441301102e-07 miRanda -0.301949028112357 1.3360117359447e-13 NA NA NA hsa-miR-3607-3p MFSD6 -2.15518588554493 1.03390728226728e-23 0.933089163217582 1.03773441301102e-07 miRNATAP -0.161618788719375 2.01361487559716e-05 NA NA NA hsa-miR-139-5p MGAT4A -2.11299531796557 8.16407076415038e-28 0.104155687943847 0.347191347682603 MirTarget;PITA;miRanda;miRNATAP -0.137279243116876 9.20461471302329e-08 NA NA NA hsa-miR-10b-3p MGAT5 2.77189254628215 2.26687582932628e-20 -0.048940912253241 0.86560089431757 mirMAP -0.104856254553034 0.0302574379597284 NA NA NA hsa-miR-33b-5p MGAT5 -2.28852395459234 2.69046626645242e-22 -0.048940912253241 0.86560089431757 mirMAP -0.155528192324667 0.0063601279333456 NA NA NA hsa-miR-139-5p MICALL1 -2.11299531796557 8.16407076415038e-28 0.470695049702067 2.04251218778669e-08 miRanda -0.121613200970561 6.2803974337453e-10 NA NA NA hsa-miR-424-5p MIPOL1 -2.62653257498508 2.38997974737991e-50 0.547353922120115 0.000260798955026953 MirTarget -0.100333823739401 0.00647827847993828 NA NA NA hsa-miR-139-5p MLEC -2.11299531796557 8.16407076415038e-28 0.720832989206975 2.19058761047913e-12 mirMAP -0.105822997716389 1.75194376066659e-05 NA NA NA hsa-miR-139-5p MLLT3 -2.11299531796557 8.16407076415038e-28 -0.149677392522711 0.542059105158668 mirMAP -0.192249672756593 0.000855059326996262 NA NA NA hsa-miR-424-5p MLLT6 -2.62653257498508 2.38997974737991e-50 0.653121837157595 1.00755151884882e-10 MirTarget -0.147589304417276 2.62535540665397e-09 NA NA NA hsa-miR-199a-3p MMAB -2.3279328685682 1.04468066198593e-17 -0.588907111339767 9.03725382920731e-05 PITA -0.117418021246502 5.44509690046316e-06 NA NA NA hsa-miR-199b-3p MMAB -2.33226605401203 9.51887435273314e-18 -0.588907111339767 9.03725382920731e-05 PITA -0.117092684922848 5.69807470972391e-06 NA NA NA hsa-miR-139-5p MMD -2.11299531796557 8.16407076415038e-28 -0.0416538737688885 0.789780769629193 miRanda -0.228319718080065 2.341145023058e-10 NA NA NA hsa-miR-33b-5p MMP16 -2.28852395459234 2.69046626645242e-22 -0.556297005522388 0.04844968434014 MirTarget -0.132356526661009 0.0175992322847814 NA NA NA hsa-miR-451a MMP9 -2.1025161666445 6.82555767537341e-17 1.49468636413798 3.25627904376465e-05 miRNAWalker2_validate;miRTarBase -0.194578310764471 0.00392266711105327 NA NA NA hsa-miR-139-5p MNX1 -2.11299531796557 8.16407076415038e-28 1.06785003790784 0.00949441679457583 miRanda -0.449757865216765 3.14337656211684e-06 NA NA NA hsa-miR-139-5p MOSPD1 -2.11299531796557 8.16407076415038e-28 0.488835757295254 0.000448347658243513 MirTarget;PITA;miRanda -0.122525053722863 0.000191370959939307 NA NA NA hsa-miR-139-5p MPP7 -2.11299531796557 8.16407076415038e-28 0.29699056404522 0.214382766609293 miRanda -0.246432640692135 1.05622589787779e-05 NA NA NA hsa-miR-139-5p MPZL1 -2.11299531796557 8.16407076415038e-28 0.782707469550616 4.62671433445359e-14 miRanda -0.288185963336547 1.12353138336791e-35 NA NA NA hsa-miR-3607-3p MPZL1 -2.15518588554493 1.03390728226728e-23 0.782707469550616 4.62671433445359e-14 mirMAP;miRNATAP -0.127962720202939 1.44051912031593e-08 NA NA NA hsa-miR-139-5p MRAP2 -2.11299531796557 8.16407076415038e-28 2.87660928044156 3.81247995261938e-12 miRanda -0.650964375686436 3.37498052590478e-11 NA NA NA hsa-miR-130b-5p MRAS 0.170599813152408 0.337611586432771 0.754170829241627 1.65059029700012e-05 mirMAP -0.138995975237236 0.00414551447496583 NA NA NA hsa-miR-15a-5p MRAS 0.349521211668244 0.000770735998804736 0.754170829241627 1.65059029700012e-05 miRNATAP -0.198825720664118 0.0170026993462943 NA NA NA hsa-miR-15b-5p MRAS 0.230566941413564 0.0824765001857479 0.754170829241627 1.65059029700012e-05 miRNATAP -0.202201006776971 0.00188220563287176 NA NA NA hsa-miR-16-5p MRAS -0.398577235179603 0.000101598495180191 0.754170829241627 1.65059029700012e-05 miRNATAP -0.329966535450367 8.18571483517898e-05 NA NA NA hsa-miR-26b-5p MRAS -1.10804856399744 4.14176110314282e-22 0.754170829241627 1.65059029700012e-05 miRNATAP -0.277911131089481 9.88725753965834e-05 NA NA NA hsa-miR-30e-3p MRAS -1.20845647373031 3.10263633528203e-25 0.754170829241627 1.65059029700012e-05 mirMAP -0.201833414955771 0.00390915382879959 NA NA NA hsa-miR-486-5p MRAS -1.77766890600022 2.9071717929922e-14 0.754170829241627 1.65059029700012e-05 miRanda -0.104774719717466 0.00324805650492037 NA NA NA hsa-miR-7-1-3p MRAS -0.569105143287799 1.85297665041424e-05 0.754170829241627 1.65059029700012e-05 mirMAP -0.221409375194795 0.000575537836289103 NA NA NA hsa-miR-10b-5p MRC2 2.86931593037303 6.97409423207806e-23 -1.08312271696391 2.04765007689324e-05 mirMAP -0.197150546055992 9.24416709764377e-07 NA NA NA hsa-miR-139-5p MSH2 -2.11299531796557 8.16407076415038e-28 1.29821037015507 5.01428242220233e-30 miRanda -0.289016195474846 1.80690007466321e-26 NA NA NA hsa-miR-139-3p MSI1 -2.53151940925585 1.56777509736867e-36 1.99071597222025 2.88067784687686e-05 PITA -0.560644803739704 1.03317079465392e-07 NA NA NA hsa-miR-144-3p MSI1 -2.97536914478815 6.00546047309683e-28 1.99071597222025 2.88067784687686e-05 miRNATAP -0.388539683937829 1.08065286816172e-06 NA NA NA hsa-miR-224-5p MSRA 2.67175249172213 1.46995328399796e-18 -1.57506926312641 2.36722319548318e-23 MirTarget -0.135325154185329 9.05929683900303e-08 NA NA NA hsa-miR-139-5p MSX1 -2.11299531796557 8.16407076415038e-28 1.64867861143844 2.50604676499963e-18 miRanda -0.194092736824484 2.62610238570598e-05 NA NA NA hsa-miR-144-3p MSX1 -2.97536914478815 6.00546047309683e-28 1.64867861143844 2.50604676499963e-18 miRNATAP -0.101183984244234 0.00214915853780227 NA NA NA hsa-miR-139-5p MTBP -2.11299531796557 8.16407076415038e-28 2.13981079884218 4.51334965904592e-29 miRanda -0.447961951525167 1.9024929712374e-22 NA NA NA hsa-miR-139-5p MTF2 -2.11299531796557 8.16407076415038e-28 0.168133266471024 0.0710258930647526 miRanda -0.127373833740326 3.2535895069333e-09 NA NA NA hsa-miR-424-5p MTMR11 -2.62653257498508 2.38997974737991e-50 1.58660342657416 2.00872981639687e-10 MirTarget -0.315253519592698 3.21610081569145e-07 NA NA NA hsa-miR-139-5p MTMR2 -2.11299531796557 8.16407076415038e-28 0.400709772822859 0.00100054348711912 PITA;miRanda -0.196804305444322 2.43701050034063e-12 NA NA NA hsa-miR-424-5p MTMR4 -2.62653257498508 2.38997974737991e-50 -0.200368056480763 0.110719290510537 MirTarget;miRNATAP -0.107760403709297 0.000423949784322482 NA NA NA hsa-miR-139-5p MXD3 -2.11299531796557 8.16407076415038e-28 1.51343901692035 1.01864686099996e-27 miRanda -0.331569069805415 1.25281250929975e-23 NA NA NA hsa-miR-424-5p MXD3 -2.62653257498508 2.38997974737991e-50 1.51343901692035 1.01864686099996e-27 miRNATAP -0.318224171219995 4.18702343789156e-20 NA NA NA hsa-miR-424-5p MXD4 -2.62653257498508 2.38997974737991e-50 0.502450250293596 6.69217891236209e-07 mirMAP -0.114873220365556 3.50697428371179e-06 NA NA NA hsa-miR-139-5p MYB -2.11299531796557 8.16407076415038e-28 0.832619773672674 0.00191922988334194 miRanda -0.436319209735813 1.8913506713086e-12 NA NA NA hsa-miR-144-3p MYB -2.97536914478815 6.00546047309683e-28 0.832619773672674 0.00191922988334194 miRNATAP -0.127402796229373 0.00475510455309564 NA NA NA hsa-miR-139-5p MYBL1 -2.11299531796557 8.16407076415038e-28 1.1480718167108 4.98869165631426e-13 PITA;miRanda;miRNATAP -0.299342110286449 9.31817004420928e-16 NA NA NA hsa-miR-144-3p MYBL1 -2.97536914478815 6.00546047309683e-28 1.1480718167108 4.98869165631426e-13 miRNATAP -0.113987284384555 2.81266659691938e-05 NA NA NA hsa-miR-424-5p MYBL1 -2.62653257498508 2.38997974737991e-50 1.1480718167108 4.98869165631426e-13 miRNATAP -0.107086244675139 0.00740055831194466 NA NA NA hsa-miR-3607-3p MYBL2 -2.15518588554493 1.03390728226728e-23 4.08434617053484 2.28158156759939e-36 miRNATAP -0.548031095326674 1.29517247240164e-13 NA NA NA hsa-miR-139-5p MYCBP -2.11299531796557 8.16407076415038e-28 0.270320437141615 0.00287712114096272 MirTarget;miRanda -0.115066776639822 4.87237988627819e-08 NA NA NA hsa-miR-139-5p MYCN -2.11299531796557 8.16407076415038e-28 2.4097398140758 1.13995179469792e-10 miRanda -0.286410571123891 0.00146804850427129 NA NA NA hsa-miR-144-3p MYCN -2.97536914478815 6.00546047309683e-28 2.4097398140758 1.13995179469792e-10 miRNATAP -0.307097355643649 1.31199376969279e-06 NA NA NA hsa-miR-139-5p MYEF2 -2.11299531796557 8.16407076415038e-28 0.808248214059432 0.0267356184561659 miRanda -0.512408528031462 1.42268395939812e-09 NA NA NA hsa-miR-144-3p MYEF2 -2.97536914478815 6.00546047309683e-28 0.808248214059432 0.0267356184561659 MirTarget -0.181473324653328 0.00300531194997691 NA NA NA hsa-miR-10b-3p MYO10 2.77189254628215 2.26687582932628e-20 -1.59578787890497 5.76385780041621e-13 mirMAP -0.215467783653917 9.74228083116713e-09 NA NA NA hsa-miR-183-5p MYO1B 2.33444328833177 1.52188109365421e-10 -1.35871038040116 5.51897953328734e-21 MirTarget -0.163489970092155 9.27159884007272e-18 NA NA NA hsa-miR-3607-3p MYO5C -2.15518588554493 1.03390728226728e-23 0.704041865777547 1.35098259847515e-06 mirMAP -0.121585821353933 0.000110215515412459 NA NA NA hsa-miR-144-3p MYT1 -2.97536914478815 6.00546047309683e-28 0.677458551399817 0.0346957760454756 miRNATAP -0.114505316550158 0.0336168602166218 NA NA NA hsa-miR-139-5p NAA25 -2.11299531796557 8.16407076415038e-28 0.338190324446254 1.67798767167482e-05 miRanda -0.121331403433055 2.56667752281473e-11 NA NA NA hsa-miR-139-5p NANOS1 -2.11299531796557 8.16407076415038e-28 0.38458031916332 0.00111708235761936 miRanda -0.116163035774335 2.78123272879872e-05 NA NA NA hsa-miR-139-5p NAP1L1 -2.11299531796557 8.16407076415038e-28 0.48873822323481 4.44413744556636e-06 PITA;miRanda -0.248619020975699 1.93851765508301e-25 NA NA NA hsa-miR-3607-3p NAV3 -2.15518588554493 1.03390728226728e-23 0.837365701189611 0.0144129652856368 MirTarget;mirMAP -0.193126516790782 0.00864687593107688 NA NA NA hsa-miR-139-5p NCK2 -2.11299531796557 8.16407076415038e-28 -0.0215428774682662 0.91249283819926 miRanda -0.110842463393205 0.0163442553896924 NA NA NA hsa-miR-3607-3p NCK2 -2.15518588554493 1.03390728226728e-23 -0.0215428774682662 0.91249283819926 MirTarget;miRNATAP -0.120152049102049 0.0041547073425204 NA NA NA hsa-miR-224-5p NCOR1 2.67175249172213 1.46995328399796e-18 -1.1474038660585 3.87233367598251e-18 MirTarget -0.11167395002456 8.49019032435628e-08 NA NA NA hsa-miR-3607-3p NCOR2 -2.15518588554493 1.03390728226728e-23 0.534673791894968 2.12570475503387e-10 miRNATAP -0.14388760189026 5.14277401033427e-16 NA NA NA hsa-miR-139-5p NDOR1 -2.11299531796557 8.16407076415038e-28 1.05020501516652 5.12624788472277e-23 mirMAP -0.23324246250664 2.43970959260157e-20 NA NA NA hsa-miR-199a-3p NDRG1 -2.3279328685682 1.04468066198593e-17 0.654480193132553 0.000503878236136277 miRNATAP -0.115233736826706 0.000377513795656279 NA NA NA hsa-miR-199b-3p NDRG1 -2.33226605401203 9.51887435273314e-18 0.654480193132553 0.000503878236136277 miRNATAP -0.115342417855258 0.000368983698538588 NA NA NA hsa-miR-139-5p NDRG3 -2.11299531796557 8.16407076415038e-28 0.941677746935019 2.65259063843979e-20 miRanda -0.255221923783428 3.03410750484218e-27 NA NA NA hsa-miR-144-3p NDRG3 -2.97536914478815 6.00546047309683e-28 0.941677746935019 2.65259063843979e-20 miRNATAP -0.138500819677161 1.16241982106115e-15 NA NA NA hsa-miR-3607-3p NDRG3 -2.15518588554493 1.03390728226728e-23 0.941677746935019 2.65259063843979e-20 miRNATAP -0.112664667930684 6.58617041713914e-07 NA NA NA hsa-miR-199a-3p NEDD4 -2.3279328685682 1.04468066198593e-17 -0.211886112092802 0.209669364741357 MirTarget;PITA;miRNATAP -0.110316228703167 0.00013315318288011 NA NA NA hsa-miR-199b-3p NEDD4 -2.33226605401203 9.51887435273314e-18 -0.211886112092802 0.209669364741357 MirTarget;PITA;miRNATAP -0.110221544641501 0.000133446343817328 NA NA NA hsa-miR-139-5p NEDD4L -2.11299531796557 8.16407076415038e-28 0.864887679249782 8.63340597856756e-11 miRanda -0.140741781260669 1.01296040869229e-05 NA NA NA hsa-miR-424-5p NEK8 -2.62653257498508 2.38997974737991e-50 0.46199330387493 0.00018443895499407 mirMAP -0.107907784758685 0.000363381963424015 NA NA NA hsa-miR-139-5p NETO2 -2.11299531796557 8.16407076415038e-28 1.83758631032726 9.72402406409219e-19 miRanda -0.256159049672303 4.29002863426153e-07 NA NA NA hsa-miR-144-3p NETO2 -2.97536914478815 6.00546047309683e-28 1.83758631032726 9.72402406409219e-19 MirTarget -0.161998202686318 7.29743672759332e-06 NA NA NA hsa-miR-139-5p NEU1 -2.11299531796557 8.16407076415038e-28 0.997671867265262 1.4440346666582e-17 miRanda -0.278051741974795 9.29688051811178e-25 NA NA NA hsa-miR-15a-5p NF1 0.349521211668244 0.000770735998804736 -0.152901353808947 0.101850652339859 MirTarget -0.148929467960257 0.000666418015083739 NA NA NA hsa-miR-16-1-3p NF1 0.392360028038559 0.00112481918108198 -0.152901353808947 0.101850652339859 MirTarget -0.108815403058878 0.0039207534759359 NA NA NA hsa-miR-29a-5p NF1 -0.113555908626946 0.349622266470788 -0.152901353808947 0.101850652339859 MirTarget;miRNATAP -0.154669081021 3.62300802631363e-05 NA NA NA hsa-miR-455-5p NF1 -0.270546034117157 0.0581320703577731 -0.152901353808947 0.101850652339859 miRanda -0.117633756266104 0.00021315047674953 NA NA NA hsa-miR-590-5p NF1 -0.103355559980404 0.310027295317092 -0.152901353808947 0.101850652339859 miRanda -0.160993447815349 0.000340896843029157 NA NA NA hsa-miR-424-5p NF2 -2.62653257498508 2.38997974737991e-50 0.664388802089412 1.31735413428132e-13 MirTarget -0.145592003132911 4.15703392984433e-11 NA NA NA hsa-miR-3607-3p NFATC4 -2.15518588554493 1.03390728226728e-23 0.864010892322999 1.90169048902368e-05 miRNATAP -0.174472801573825 6.00001387189594e-05 NA NA NA hsa-miR-139-5p NFE2L3 -2.11299531796557 8.16407076415038e-28 0.726351453895024 0.000248188305311381 miRanda -0.385216750476443 1.65843231184369e-17 NA NA NA hsa-miR-15a-5p NFKB1 0.349521211668244 0.000770735998804736 -0.538916955748098 1.42993670239858e-08 miRNAWalker2_validate -0.153048958379264 0.000730484492411411 NA NA NA hsa-miR-548j-5p NFKB1 0.251239647701947 0.171361975450222 -0.538916955748098 1.42993670239858e-08 MirTarget -0.106885227436574 4.88574003092244e-05 NA NA NA hsa-miR-92a-3p NFKB1 0.212391012518195 0.134292268089997 -0.538916955748098 1.42993670239858e-08 miRNAWalker2_validate -0.147016189975437 8.47280185007855e-06 NA NA NA hsa-miR-424-5p NFRKB -2.62653257498508 2.38997974737991e-50 0.563199098001803 5.81802378481685e-14 MirTarget;miRNATAP -0.13361243498643 2.96968189901575e-13 NA NA NA hsa-miR-423-5p NGF 0.698807775906485 1.02195196334612e-11 -1.13456502234037 7.24473953628721e-08 MirTarget;miRNATAP -0.447502128127762 6.35933337883299e-06 NA NA NA hsa-miR-10b-5p NGFR 2.86931593037303 6.97409423207806e-23 -3.21029001367102 1.44390076140831e-24 mirMAP -0.397416303249616 6.91420749264163e-15 NA NA NA hsa-miR-15b-3p NGFR 0.238105490431193 0.0997721500357416 -3.21029001367102 1.44390076140831e-24 mirMAP -0.50964422238366 5.10367178136392e-06 NA NA NA hsa-miR-34a-5p NGFR 1.03694231790865 5.74864019540594e-14 -3.21029001367102 1.44390076140831e-24 mirMAP -0.558348892128834 8.29526099358313e-07 NA NA NA hsa-miR-361-3p NGFR 0.275658012727111 0.00549374744374488 -3.21029001367102 1.44390076140831e-24 mirMAP -0.377929209104062 0.0220647733147329 NA NA NA hsa-miR-424-5p NISCH -2.62653257498508 2.38997974737991e-50 0.507250570071013 8.5871679565154e-14 MirTarget -0.143470757839452 1.69522538972791e-18 NA NA NA hsa-miR-3607-3p NKTR -2.15518588554493 1.03390728226728e-23 0.473169872664043 0.000140527697400655 MirTarget;miRNATAP -0.121044655984185 5.22103090738098e-06 NA NA NA hsa-miR-139-5p NKX3-2 -2.11299531796557 8.16407076415038e-28 1.50356509395594 2.81830959678589e-06 miRanda -0.635220175802096 6.00986798251726e-18 NA NA NA hsa-miR-224-5p NOTUM 2.67175249172213 1.46995328399796e-18 -1.17730442898329 0.0328082876893716 MirTarget -0.232235222497022 0.0061019792033052 NA NA NA hsa-miR-139-3p NOX4 -2.53151940925585 1.56777509736867e-36 2.85543175218989 1.84008744683765e-40 MirTarget -0.327328137069534 2.32036082870736e-10 NA NA NA hsa-miR-139-5p NPEPPS -2.11299531796557 8.16407076415038e-28 0.261825419108992 0.00402637895532677 miRanda -0.113988546569871 7.29168381534022e-08 NA NA NA hsa-miR-144-3p NPNT -2.97536914478815 6.00546047309683e-28 0.531754123141975 0.0583025915811082 miRNATAP -0.108809276232724 0.0209629005776517 NA NA NA hsa-miR-3607-3p NPNT -2.15518588554493 1.03390728226728e-23 0.531754123141975 0.0583025915811082 miRNATAP -0.142624430400032 0.0180381959193271 NA NA NA hsa-miR-224-5p NPR1 2.67175249172213 1.46995328399796e-18 -0.648767166027858 9.05857509351704e-05 MirTarget -0.110729395130178 1.3079108124174e-05 NA NA NA hsa-miR-10b-3p NPR3 2.77189254628215 2.26687582932628e-20 -1.42920372769258 1.19506405595807e-05 mirMAP -0.227722902229096 3.29630807513513e-05 NA NA NA hsa-miR-139-5p NPTX1 -2.11299531796557 8.16407076415038e-28 0.929025880461533 0.00584289763512414 PITA;miRanda;miRNATAP -0.463273000721401 3.44833804470163e-09 NA NA NA hsa-miR-144-3p NPTX1 -2.97536914478815 6.00546047309683e-28 0.929025880461533 0.00584289763512414 miRNATAP -0.185461193456024 0.00103326654581877 NA NA NA hsa-miR-33b-5p NPTX1 -2.28852395459234 2.69046626645242e-22 0.929025880461533 0.00584289763512414 mirMAP -0.256648002507276 0.000112227714267813 NA NA NA hsa-miR-10b-5p NPTXR 2.86931593037303 6.97409423207806e-23 -0.560890830244132 0.0974541871007386 mirMAP -0.161720990869271 0.00249177699904701 NA NA NA hsa-miR-3607-3p NQO1 -2.15518588554493 1.03390728226728e-23 3.00847629540649 1.13827228007453e-10 mirMAP -0.228789022916933 0.0256861600589079 NA NA NA hsa-miR-10b-5p NR4A3 2.86931593037303 6.97409423207806e-23 -2.64615718032537 4.58567603389215e-23 miRNAWalker2_validate -0.20428320743522 4.13376389553933e-06 22259248 An RNA molecule sequence exactly matching the mature mir-10b minor antisense showed strong inhibition when mixed with PLL in a wound-healing assay with human breast cell line MDA-MB-231 breast cancer hsa-miR-10b-5p NR5A2 2.86931593037303 6.97409423207806e-23 -0.702868109735867 0.000206279883850417 miRNATAP -0.100011037462782 0.000879703070423026 NA NA NA hsa-let-7b-5p NRAS -0.959013717270803 5.95127281258643e-11 0.301156333096785 0.000285671613438218 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.105903409272711 8.57245668973746e-05 20607356 Transfection of let-7 miRNA reduced expression of pan-RAS N-RAS and K-RAS in the glioblastoma cells glioblastoma hsa-miR-126-5p NRAS -0.428561469405594 6.6035585844222e-05 0.301156333096785 0.000285671613438218 mirMAP -0.145651073417946 0.000106824688349933 NA NA NA hsa-miR-145-5p NRAS -1.4795885711477 6.47308361543414e-16 0.301156333096785 0.000285671613438218 miRNAWalker2_validate;MirTarget;miRNATAP -0.120395847533196 1.03194548202048e-08 26973415 miR-145 expression was significantly downregulated in colon cancer tissues with its expression in normal colonic tissues being 4-5-fold higher two sample t test P < 0.05 whereas N-ras expression showed the opposite trend colon cancer hsa-miR-22-3p NRAS -0.628561621952407 1.33755558015523e-09 0.301156333096785 0.000285671613438218 MirTarget;miRNATAP -0.287363482934569 1.84836871548684e-14 NA NA NA hsa-miR-29a-3p NRAS -0.856762511178136 4.65330336378459e-12 0.301156333096785 0.000285671613438218 miRNATAP -0.111209986118726 0.000497462508043792 NA NA NA hsa-miR-29b-3p NRAS -0.348885528720517 0.0121441341291285 0.301156333096785 0.000285671613438218 miRNATAP -0.163441778679427 1.31476396622707e-08 NA NA NA hsa-miR-29c-3p NRAS -1.4367517608807 1.61767774905781e-21 0.301156333096785 0.000285671613438218 miRNATAP -0.195416271463693 3.04370398757482e-15 NA NA NA hsa-miR-664a-3p NRAS 0.485807855553031 0.000732553249798598 0.301156333096785 0.000285671613438218 MirTarget -0.123577371649095 9.58480979576424e-06 NA NA NA hsa-miR-199a-3p NRBP2 -2.3279328685682 1.04468066198593e-17 0.559574574924087 0.000815031688707047 MirTarget -0.128591107278892 7.14840449928481e-06 NA NA NA hsa-miR-199b-3p NRBP2 -2.33226605401203 9.51887435273314e-18 0.559574574924087 0.000815031688707047 MirTarget -0.128412262581638 7.25289993229791e-06 NA NA NA hsa-miR-139-5p NRCAM -2.11299531796557 8.16407076415038e-28 1.19678747151501 0.00935952256234585 PITA;miRanda -0.651268718779298 1.1382607683058e-09 NA NA NA hsa-miR-183-5p NRG1 2.33444328833177 1.52188109365421e-10 -3.95953255287574 8.76353628841238e-16 miRNATAP -0.177019046971196 0.00791147318619496 NA NA NA hsa-miR-139-3p NRG2 -2.53151940925585 1.56777509736867e-36 1.49132909810151 2.52337889875853e-05 MirTarget -0.239253464992008 0.00254510120936391 NA NA NA hsa-miR-139-5p NT5DC3 -2.11299531796557 8.16407076415038e-28 0.33831387162715 0.0111644086404084 mirMAP -0.115420691473241 0.000230078471604769 NA NA NA hsa-miR-21-5p NTF3 1.51084295924322 1.54551622173259e-34 -3.97962534066229 2.44784627289438e-41 miRTarBase;miRNATAP -1.02982933864977 2.33503442659123e-19 NA NA NA hsa-miR-221-3p NTF3 1.12244756358612 3.48370308238012e-13 -3.97962534066229 2.44784627289438e-41 miRNATAP -0.487132834663555 1.03773554125066e-06 NA NA NA hsa-miR-222-3p NTF3 1.08574156066353 1.76407192348131e-11 -3.97962534066229 2.44784627289438e-41 miRNATAP -0.44960074696525 2.69176815020579e-06 NA NA NA hsa-miR-374a-5p NTF3 0.016390363747302 0.869784217438621 -3.97962534066229 2.44784627289438e-41 mirMAP -0.321968278741428 0.0469289556567102 NA NA NA hsa-miR-421 NTF3 0.941856334694081 6.12167297054077e-08 -3.97962534066229 2.44784627289438e-41 miRanda -0.509139650144783 1.28862404044202e-08 NA NA NA hsa-miR-548v NTF3 -0.27258775900243 0.176259917595269 -3.97962534066229 2.44784627289438e-41 miRNATAP -0.174836141753527 0.0298863778497204 NA NA NA hsa-miR-590-5p NTF3 -0.103355559980404 0.310027295317092 -3.97962534066229 2.44784627289438e-41 PITA;miRanda;miRNATAP -0.438231227038025 0.00572599858717309 NA NA NA hsa-miR-107 NTRK2 0.241662461253461 0.0170788899505389 -2.30467079336051 6.66762032408277e-09 PITA;miRanda -1.0598585629804 4.58121558377307e-08 NA NA NA hsa-miR-130b-3p NTRK2 0.687190305027546 0.000109068658562255 -2.30467079336051 6.66762032408277e-09 mirMAP -0.437506702355608 6.88196102565667e-05 NA NA NA hsa-miR-130b-5p NTRK2 0.170599813152408 0.337611586432771 -2.30467079336051 6.66762032408277e-09 mirMAP -0.366083689585264 0.000970429145511043 NA NA NA hsa-miR-140-3p NTRK2 0.546012239205329 4.84578261098777e-11 -2.30467079336051 6.66762032408277e-09 PITA -0.621765702538706 0.00841531471617843 NA NA NA hsa-miR-146b-5p NTRK2 0.419719546795449 0.0457375823220155 -2.30467079336051 6.66762032408277e-09 PITA;miRanda -0.211307147584135 0.0245992788491132 NA NA NA hsa-miR-148a-5p NTRK2 -0.767626696027761 1.08359477494797e-06 -2.30467079336051 6.66762032408277e-09 mirMAP -0.636528653670575 2.11782031176256e-07 NA NA NA hsa-miR-151a-5p NTRK2 0.484893436232714 4.8995594459361e-06 -2.30467079336051 6.66762032408277e-09 miRNATAP -1.33321264979205 1.53079430764618e-13 NA NA NA hsa-miR-17-3p NTRK2 0.410352776142368 0.00422200500748636 -2.30467079336051 6.66762032408277e-09 miRNATAP -0.453219975208752 0.000970000263503074 NA NA NA hsa-miR-185-5p NTRK2 0.480006257154717 6.35758891340152e-07 -2.30467079336051 6.66762032408277e-09 mirMAP -0.706902324923139 0.000526512526055176 NA NA NA hsa-miR-186-5p NTRK2 -0.060103391373687 0.535288717081205 -2.30467079336051 6.66762032408277e-09 mirMAP -0.615456145703442 0.00282417325117072 NA NA NA hsa-miR-20a-3p NTRK2 -0.318177901603857 0.0467885456739855 -2.30467079336051 6.66762032408277e-09 mirMAP -0.252683785936952 0.0414690931446268 NA NA NA hsa-miR-21-5p NTRK2 1.51084295924322 1.54551622173259e-34 -2.30467079336051 6.66762032408277e-09 mirMAP -0.307805996175828 0.0376038333861936 NA NA NA hsa-miR-224-3p NTRK2 1.40770116795301 1.31426607144612e-08 -2.30467079336051 6.66762032408277e-09 mirMAP -0.174340903906123 0.0281465723728938 NA NA NA hsa-miR-29a-5p NTRK2 -0.113555908626946 0.349622266470788 -2.30467079336051 6.66762032408277e-09 mirMAP -0.496197551946914 0.0024225319944222 NA NA NA hsa-miR-30d-5p NTRK2 0.718283816348023 2.47422074061352e-08 -2.30467079336051 6.66762032408277e-09 mirMAP -0.544492350069766 0.000308238247398339 NA NA NA hsa-miR-32-3p NTRK2 0.219109440121582 0.207217051619543 -2.30467079336051 6.66762032408277e-09 mirMAP -0.57730597526211 7.07844368508117e-07 NA NA NA hsa-miR-32-5p NTRK2 0.0806126674664016 0.548984992497432 -2.30467079336051 6.66762032408277e-09 mirMAP -0.873196576871784 1.76759042639064e-09 NA NA NA hsa-miR-361-5p NTRK2 0.233202959858696 0.00961572812255327 -2.30467079336051 6.66762032408277e-09 miRanda;mirMAP -0.961236007085446 1.26833159807763e-05 NA NA NA hsa-miR-362-5p NTRK2 0.717921690799312 1.68392734504524e-05 -2.30467079336051 6.66762032408277e-09 mirMAP -0.270778909733059 0.0212632750995269 NA NA NA hsa-miR-374a-5p NTRK2 0.016390363747302 0.869784217438621 -2.30467079336051 6.66762032408277e-09 mirMAP -1.03030330133654 1.83192331027079e-07 NA NA NA hsa-miR-374b-5p NTRK2 -0.307538028546424 0.0030079617545972 -2.30467079336051 6.66762032408277e-09 mirMAP -0.718532230574976 0.000166156599301286 NA NA NA hsa-miR-421 NTRK2 0.941856334694081 6.12167297054077e-08 -2.30467079336051 6.66762032408277e-09 mirMAP -0.382342771285455 0.00064249983773967 NA NA NA hsa-miR-452-3p NTRK2 1.76909792952222 2.98172274671408e-10 -2.30467079336051 6.66762032408277e-09 mirMAP -0.190953329238523 0.00547983200575232 NA NA NA hsa-miR-452-5p NTRK2 1.91544498799508 1.81995982853313e-14 -2.30467079336051 6.66762032408277e-09 mirMAP -0.282969267239225 0.00019818202707022 NA NA NA hsa-miR-454-3p NTRK2 0.668749059573955 2.42670710515113e-06 -2.30467079336051 6.66762032408277e-09 mirMAP -0.311685637362346 0.0241479721311884 NA NA NA hsa-miR-455-3p NTRK2 -1.3998033821095 5.72010709806871e-17 -2.30467079336051 6.66762032408277e-09 mirMAP -0.236935148889472 0.0374236181020148 NA NA NA hsa-miR-532-5p NTRK2 1.02729546510601 9.93318913966636e-16 -2.30467079336051 6.66762032408277e-09 PITA -0.875128303330166 2.62964705553226e-09 NA NA NA hsa-miR-590-5p NTRK2 -0.103355559980404 0.310027295317092 -2.30467079336051 6.66762032408277e-09 miRanda;mirMAP -0.691661076913071 0.00040270354048443 NA NA NA hsa-miR-618 NTRK2 0.13539895350352 0.517145913114103 -2.30467079336051 6.66762032408277e-09 mirMAP -0.622793706501262 8.5230387177889e-11 NA NA NA hsa-miR-3607-3p NUAK1 -2.15518588554493 1.03390728226728e-23 0.794259973271986 6.86027622473925e-11 MirTarget;miRNATAP -0.139781893369011 1.12411475101937e-07 NA NA NA hsa-miR-424-5p NUCKS1 -2.62653257498508 2.38997974737991e-50 0.233441981946634 0.00385604321474218 MirTarget;miRNATAP -0.108965093232376 2.08500233467438e-08 NA NA NA hsa-miR-139-5p NUP107 -2.11299531796557 8.16407076415038e-28 0.643936387307661 3.387926692923e-13 miRanda -0.15393399854057 1.38480434410167e-13 NA NA NA hsa-miR-139-5p NUP210 -2.11299531796557 8.16407076415038e-28 0.782751605380779 4.03899169947893e-10 miRanda -0.271010478634646 3.46611899042497e-21 NA NA NA hsa-miR-424-5p NUP210 -2.62653257498508 2.38997974737991e-50 0.782751605380779 4.03899169947893e-10 MirTarget -0.145629539121609 2.54709781809462e-06 NA NA NA hsa-miR-139-5p NUP37 -2.11299531796557 8.16407076415038e-28 0.861270149171436 7.17055072480877e-21 miRanda -0.226921953323175 1.98664789317752e-26 NA NA NA hsa-miR-139-5p NUTF2 -2.11299531796557 8.16407076415038e-28 0.423273750605189 1.29748402471219e-05 miRanda -0.134833871502749 2.62056121746358e-09 NA NA NA hsa-miR-139-5p NXF2 -2.11299531796557 8.16407076415038e-28 0.852767439315861 0.0384937249056658 miRanda -0.269446469847596 0.00559035321792838 NA NA NA hsa-miR-139-5p OCRL -2.11299531796557 8.16407076415038e-28 0.818629455066819 1.52199258091119e-16 miRanda -0.153978378005478 8.63938699032372e-11 NA NA NA hsa-miR-424-5p OGT -2.62653257498508 2.38997974737991e-50 0.641051374032147 6.95763329953705e-13 miRNATAP -0.128874136744259 4.93490333020518e-09 NA NA NA hsa-miR-139-5p OIP5 -2.11299531796557 8.16407076415038e-28 2.94467357918934 2.50419782910699e-34 miRanda -0.724552832755235 1.06870820112153e-37 NA NA NA hsa-miR-139-5p OPA3 -2.11299531796557 8.16407076415038e-28 0.291125258853402 0.000184092538128601 mirMAP -0.112073062449165 5.13809072249369e-10 NA NA NA hsa-miR-139-5p OPN3 -2.11299531796557 8.16407076415038e-28 0.605073571980075 7.59189180325343e-05 miRanda -0.189128984706639 1.32284226666227e-07 NA NA NA hsa-miR-3607-3p ORAI2 -2.15518588554493 1.03390728226728e-23 0.147939436354318 0.336648923993268 mirMAP -0.110774309053649 0.000749501601482951 NA NA NA hsa-miR-139-5p ORAOV1 -2.11299531796557 8.16407076415038e-28 0.807281109818585 7.20035987668661e-08 miRanda -0.129742363742786 0.000281676960460714 NA NA NA hsa-miR-3607-3p ORAOV1 -2.15518588554493 1.03390728226728e-23 0.807281109818585 7.20035987668661e-08 MirTarget -0.113179109230838 0.000499195330926899 NA NA NA hsa-miR-3607-3p OSR1 -2.15518588554493 1.03390728226728e-23 0.85668860217344 0.00884127717216095 MirTarget;miRNATAP -0.184322937466347 0.0088011474208412 NA NA NA hsa-miR-139-5p OSR2 -2.11299531796557 8.16407076415038e-28 2.36025944761105 3.77968823665534e-09 PITA;miRanda -0.452875539511494 2.05386838129302e-06 NA NA NA hsa-miR-139-5p OTUB2 -2.11299531796557 8.16407076415038e-28 1.59577360116419 6.69566513486211e-29 miRanda -0.204813770587562 8.83790783987847e-09 NA NA NA hsa-miR-3607-3p OTUD3 -2.15518588554493 1.03390728226728e-23 0.701071239885856 4.04593404284281e-08 mirMAP -0.172161092379887 2.66682309069057e-10 NA NA NA hsa-miR-424-5p OTX1 -2.62653257498508 2.38997974737991e-50 3.02229789234294 1.88083127727288e-19 miRNATAP -0.462698658206566 4.68705734759636e-08 NA NA NA hsa-miR-139-5p PABPC1 -2.11299531796557 8.16407076415038e-28 0.734137538715334 7.38475099842446e-08 miRanda -0.165867876000481 2.69858050412684e-07 NA NA NA hsa-miR-139-3p PABPC1L -2.53151940925585 1.56777509736867e-36 1.82462630835346 3.37061054306887e-22 miRNATAP -0.437752901645329 5.21168626324637e-26 NA NA NA hsa-miR-3607-3p PABPC4L -2.15518588554493 1.03390728226728e-23 1.27596977567225 8.30822407761245e-12 mirMAP;miRNATAP -0.129117724729017 0.00164006005671884 NA NA NA hsa-miR-224-5p PACRG 2.67175249172213 1.46995328399796e-18 -1.70413035437494 7.21588441052533e-07 MirTarget -0.255490001508426 1.37984538591799e-06 NA NA NA hsa-miR-10b-5p PAIP2B 2.86931593037303 6.97409423207806e-23 -2.26694774889415 1.51639004034747e-12 mirMAP -0.120466142561025 0.0209968476990198 NA NA NA hsa-miR-224-5p PAIP2B 2.67175249172213 1.46995328399796e-18 -2.26694774889415 1.51639004034747e-12 mirMAP -0.258518520518523 2.28669165250893e-07 NA NA NA hsa-miR-26b-5p PAK1 -1.10804856399744 4.14176110314282e-22 0.490305811595647 8.62539331382885e-05 miRNAWalker2_validate -0.15891257466612 0.00180470284259943 NA NA NA hsa-miR-30c-1-3p PAK1 -1.39373825444537 6.39912952911454e-17 0.490305811595647 8.62539331382885e-05 MirTarget -0.113092896023759 0.00158300734497847 NA NA NA hsa-miR-107 PAK3 0.241662461253461 0.0170788899505389 0.150855460957377 0.674226767074732 miRanda -0.391649830812869 0.0245401669519304 NA NA NA hsa-miR-122-5p PAK3 -1.23907441373955 4.42181244888642e-06 0.150855460957377 0.674226767074732 miRNATAP -0.174486033983843 0.00636485178121095 NA NA NA hsa-miR-146b-3p PAK3 -1.20799545896423 2.19859530890688e-09 0.150855460957377 0.674226767074732 MirTarget;miRNATAP -0.288278398127143 0.00066147857082055 NA NA NA hsa-miR-146b-5p PAK3 0.419719546795449 0.0457375823220155 0.150855460957377 0.674226767074732 miRanda -0.288743894927408 0.000493441932863671 NA NA NA hsa-miR-23b-3p PAK3 -0.530561587109023 5.43807206823652e-07 0.150855460957377 0.674226767074732 MirTarget -1.04087863702056 1.00397902530375e-10 NA NA NA hsa-miR-361-5p PAK3 0.233202959858696 0.00961572812255327 0.150855460957377 0.674226767074732 miRanda -0.730147757897168 0.000188049690426901 NA NA NA hsa-miR-455-5p PAK3 -0.270546034117157 0.0581320703577731 0.150855460957377 0.674226767074732 miRanda -0.701253277265095 6.5172343656553e-09 NA NA NA hsa-miR-548b-3p PAK3 -0.0203576084717134 0.930819503166956 0.150855460957377 0.674226767074732 miRNATAP -0.288464557985013 0.00012741993160529 NA NA NA hsa-miR-590-5p PAK3 -0.103355559980404 0.310027295317092 0.150855460957377 0.674226767074732 miRanda -0.412485667738842 0.0175992978017711 NA NA NA hsa-let-7c-5p PAK4 -1.70744661345097 2.87934212005942e-20 0.332066945941027 0.000554855795687645 miRNAWalker2_validate -0.146202847790971 7.66415471826461e-10 NA NA NA hsa-miR-145-5p PAK4 -1.4795885711477 6.47308361543414e-16 0.332066945941027 0.000554855795687645 miRNAWalker2_validate;miRTarBase -0.118651468400972 1.29791519135524e-06 23499891 We further demonstrated that miR-145 directly targeted catenin δ-1 contributing to the aberrant translocation of β-catenin through impaired nuclear shuttling with p21-activated kinase 4 PAK4 colon cancer hsa-miR-193b-3p PAK4 -0.166697207281748 0.272022543069482 0.332066945941027 0.000554855795687645 miRNATAP -0.158152191163598 2.63218670304291e-07 NA NA NA hsa-miR-192-5p PAK6 -0.50188499512787 0.00344713341196035 0.189417226280461 0.547602921696693 miRNAWalker2_validate -0.370069240297406 2.99780053131704e-05 NA NA NA hsa-miR-26b-5p PAK6 -1.10804856399744 4.14176110314282e-22 0.189417226280461 0.547602921696693 miRNAWalker2_validate -0.280082136072336 0.0285753189666136 NA NA NA hsa-miR-10b-3p PAPPA 2.77189254628215 2.26687582932628e-20 -1.03415639268326 0.000196134327811758 mirMAP -0.167005274388592 0.000341839096525799 NA NA NA hsa-miR-139-5p PAQR8 -2.11299531796557 8.16407076415038e-28 0.592484852225167 0.00429681645950127 miRanda -0.184021931550917 0.000165525081451507 NA NA NA hsa-miR-3607-3p PARM1 -2.15518588554493 1.03390728226728e-23 0.492215081013945 0.0241931172963899 mirMAP -0.136795574494209 0.00349432969910898 NA NA NA hsa-miR-424-5p PCBP4 -2.62653257498508 2.38997974737991e-50 1.08551361354041 1.48859990502195e-18 MirTarget -0.203415200757108 4.17362563919448e-11 NA NA NA hsa-miR-3607-3p PCDH17 -2.15518588554493 1.03390728226728e-23 1.14188483229928 4.69947531605855e-09 MirTarget;miRNATAP -0.111145560011984 0.00904992182993205 NA NA NA hsa-miR-424-5p PCDHA1 -2.62653257498508 2.38997974737991e-50 2.03421582854944 8.2069018136988e-06 MirTarget -0.357988371046846 0.00147047897766721 NA NA NA hsa-miR-139-5p PCDHGA1 -2.11299531796557 8.16407076415038e-28 0.777186902335941 0.00734094107410025 miRanda -0.190036523028091 0.00554309014131515 NA NA NA hsa-miR-1269a PCDHGA12 3.57543539205634 4.25369619949175e-08 -1.4569375354943 7.59527476984671e-06 MirTarget -0.102932321136316 4.51083433376583e-05 NA NA NA hsa-miR-1269a PCDHGB7 3.57543539205634 4.25369619949175e-08 -1.79699736286998 2.32981143938663e-09 MirTarget -0.1039322283759 9.7176512192091e-06 NA NA NA hsa-miR-424-5p PCYT2 -2.62653257498508 2.38997974737991e-50 0.00446147360920346 0.974419085805155 mirMAP -0.156032415130408 3.5140938690082e-06 NA NA NA hsa-miR-424-5p PDAP1 -2.62653257498508 2.38997974737991e-50 0.370793046857734 1.48674950276439e-07 miRNATAP -0.117563472701173 4.45768995843611e-12 NA NA NA hsa-miR-424-5p PDDC1 -2.62653257498508 2.38997974737991e-50 0.533443153710714 1.8670143731137e-08 mirMAP -0.144285179448841 4.05235078909854e-10 NA NA NA hsa-miR-139-5p PDE4A -2.11299531796557 8.16407076415038e-28 -0.161954171824426 0.42151694325105 PITA;miRanda;miRNATAP -0.148771674145835 0.00167868767236708 NA NA NA hsa-miR-139-5p PDE7A -2.11299531796557 8.16407076415038e-28 0.618942548594589 4.1802831988075e-06 miRanda -0.25264721131557 2.92907212381738e-16 NA NA NA hsa-miR-548v PDGFA -0.27258775900243 0.176259917595269 1.77758746228644 4.60244665196294e-16 miRNATAP -0.278647806801463 4.33621753073177e-07 NA NA NA hsa-miR-576-5p PDGFA -0.377452008285847 0.00470735657343984 1.77758746228644 4.60244665196294e-16 mirMAP -0.349423515951374 2.28885449982783e-05 NA NA NA hsa-miR-590-3p PDGFA -0.473167498047808 1.76652934637227e-05 1.77758746228644 4.60244665196294e-16 miRanda -0.229964234430781 0.0220738265001747 NA NA NA hsa-miR-590-5p PDGFA -0.103355559980404 0.310027295317092 1.77758746228644 4.60244665196294e-16 miRanda -0.222681125669574 0.0433369072703964 NA NA NA hsa-miR-140-5p PDGFB -0.220106443070144 0.0140713197101242 0.990792072539177 3.84799134063219e-14 miRanda -0.224478580392745 0.00250343524846709 NA NA NA hsa-miR-146b-3p PDGFB -1.20799545896423 2.19859530890688e-09 0.990792072539177 3.84799134063219e-14 miRNAWalker2_validate -0.116559540687373 0.000253813958503156 NA NA NA hsa-miR-26b-5p PDGFB -1.10804856399744 4.14176110314282e-22 0.990792072539177 3.84799134063219e-14 miRNAWalker2_validate -0.212037229772437 0.000102211416676722 NA NA NA hsa-miR-590-3p PDGFB -0.473167498047808 1.76652934637227e-05 0.990792072539177 3.84799134063219e-14 PITA;miRanda;miRNATAP -0.219997217412303 0.0002136212610643 NA NA NA hsa-miR-330-5p PDGFC 0.442231058604099 0.0053308560843808 -1.16709365311198 9.87240279618114e-13 miRanda -0.189791877631495 0.000224957238024521 NA NA NA hsa-miR-338-5p PDGFC -0.221898432884726 0.252390988727086 -1.16709365311198 9.87240279618114e-13 PITA;mirMAP -0.101247520784676 0.0175631963874953 NA NA NA hsa-miR-421 PDGFC 0.941856334694081 6.12167297054077e-08 -1.16709365311198 9.87240279618114e-13 miRanda -0.204828970017518 9.80030445969004e-06 NA NA NA hsa-miR-616-5p PDGFC 0.150569904638223 0.402836556304524 -1.16709365311198 9.87240279618114e-13 mirMAP -0.117734626934104 0.0101803492366224 NA NA NA hsa-miR-19b-1-5p PDGFD -0.277804782598538 0.0783067794722916 -0.0269386365998936 0.892577700101127 MirTarget -0.205584831358073 0.000829574339946887 NA NA NA hsa-miR-374a-5p PDGFD 0.016390363747302 0.869784217438621 -0.0269386365998936 0.892577700101127 MirTarget;mirMAP -0.299837460978545 0.00225563529280101 NA NA NA hsa-miR-374b-5p PDGFD -0.307538028546424 0.0030079617545972 -0.0269386365998936 0.892577700101127 MirTarget;mirMAP -0.201743583034363 0.0325177796404566 NA NA NA hsa-miR-590-5p PDGFD -0.103355559980404 0.310027295317092 -0.0269386365998936 0.892577700101127 miRanda -0.576413829030147 1.16311264268507e-09 NA NA NA hsa-miR-106b-5p PDGFRA 0.648901865047099 8.24870862047885e-09 -3.44515402293711 2.35408080284508e-16 MirTarget;miRNATAP -0.667814276068908 0.000339494510953522 NA NA NA hsa-miR-130b-3p PDGFRA 0.687190305027546 0.000109068658562255 -3.44515402293711 2.35408080284508e-16 MirTarget;miRNATAP -0.27288450220634 0.0220988786766541 NA NA NA hsa-miR-16-1-3p PDGFRA 0.392360028038559 0.00112481918108198 -3.44515402293711 2.35408080284508e-16 MirTarget -0.455470735424255 0.0100760853835697 NA NA NA hsa-miR-17-5p PDGFRA 0.698861147045461 2.43854106455398e-05 -3.44515402293711 2.35408080284508e-16 MirTarget;TargetScan;miRNATAP -0.301060598129415 0.0184115225222299 NA NA NA hsa-miR-186-5p PDGFRA -0.060103391373687 0.535288717081205 -3.44515402293711 2.35408080284508e-16 MirTarget -0.517191550482643 0.0201679817155254 NA NA NA hsa-miR-20a-5p PDGFRA 0.854326758727003 5.04256669663285e-07 -3.44515402293711 2.35408080284508e-16 MirTarget;miRNATAP -0.429411714989606 0.000497563648177803 NA NA NA hsa-miR-219a-5p PDGFRA 0.17600389823009 0.322694100196276 -3.44515402293711 2.35408080284508e-16 MirTarget -0.52063936637308 1.57138286329894e-05 NA NA NA hsa-miR-224-5p PDGFRA 2.67175249172213 1.46995328399796e-18 -3.44515402293711 2.35408080284508e-16 MirTarget -0.144194650399763 0.0314446126609986 NA NA NA hsa-miR-34a-5p PDGFRA 1.03694231790865 5.74864019540594e-14 -3.44515402293711 2.35408080284508e-16 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -1.20419826674778 7.99910511006868e-17 22750848 Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network glioblastoma hsa-miR-362-3p PDGFRA 0.814007335895913 2.00108618836568e-09 -3.44515402293711 2.35408080284508e-16 miRanda -0.626878498986425 4.42986522053939e-05 NA NA NA hsa-miR-374a-5p PDGFRA 0.016390363747302 0.869784217438621 -3.44515402293711 2.35408080284508e-16 mirMAP -0.904441562316791 2.39983127114498e-05 NA NA NA hsa-miR-374b-5p PDGFRA -0.307538028546424 0.0030079617545972 -3.44515402293711 2.35408080284508e-16 mirMAP -0.548120366479417 0.00796437271353305 NA NA NA hsa-miR-421 PDGFRA 0.941856334694081 6.12167297054077e-08 -3.44515402293711 2.35408080284508e-16 PITA;miRanda;miRNATAP -0.45565181782464 0.000157204289652031 NA NA NA hsa-miR-508-3p PDGFRA 1.48874058858819 8.16277343202446e-07 -3.44515402293711 2.35408080284508e-16 miRNATAP -0.156030702769891 0.0288423520978966 NA NA NA hsa-miR-550a-5p PDGFRA 0.156224023171823 0.282505553619229 -3.44515402293711 2.35408080284508e-16 MirTarget -0.31126174887629 0.034790870613107 NA NA NA hsa-miR-616-5p PDGFRA 0.150569904638223 0.402836556304524 -3.44515402293711 2.35408080284508e-16 mirMAP -0.412847880089754 0.000492619399212517 NA NA NA hsa-miR-664a-3p PDGFRA 0.485807855553031 0.000732553249798598 -3.44515402293711 2.35408080284508e-16 mirMAP -0.303055641401418 0.040509663243103 NA NA NA hsa-miR-93-5p PDGFRA 1.39518349670953 2.84167728726712e-25 -3.44515402293711 2.35408080284508e-16 MirTarget;miRNATAP -0.842533275875607 1.07321761969733e-08 NA NA NA hsa-miR-28-5p PDGFRB -0.430964830599964 2.67367257252925e-06 0.903688818724302 2.6429876964178e-08 miRanda -0.310145998507964 0.000393892179655548 NA NA NA hsa-miR-29a-3p PDGFRB -0.856762511178136 4.65330336378459e-12 0.903688818724302 2.6429876964178e-08 miRNATAP -0.17841922996433 0.00500595280694788 NA NA NA hsa-miR-29c-3p PDGFRB -1.4367517608807 1.61767774905781e-21 0.903688818724302 2.6429876964178e-08 miRNATAP -0.139148992716859 0.00615874031219039 NA NA NA hsa-miR-486-5p PDGFRB -1.77766890600022 2.9071717929922e-14 0.903688818724302 2.6429876964178e-08 miRanda -0.142065402424595 1.73938186674638e-05 NA NA NA hsa-miR-491-5p PDGFRB -0.369122930844418 0.0154047757048929 0.903688818724302 2.6429876964178e-08 miRanda -0.111615186915209 0.0368171058633019 NA NA NA hsa-miR-424-5p PDPK1 -2.62653257498508 2.38997974737991e-50 0.309856812256619 0.0145897035970451 mirMAP -0.106052465451978 0.000611771334502943 NA NA NA hsa-miR-3607-3p PDPN -2.15518588554493 1.03390728226728e-23 -0.406155871865531 0.33428853245946 mirMAP -0.207667584966194 0.0213661465240536 NA NA NA hsa-miR-424-5p PDXK -2.62653257498508 2.38997974737991e-50 0.60795962520192 3.81588352286127e-09 MirTarget;mirMAP -0.157658894193652 3.72580696592584e-10 NA NA NA hsa-miR-3607-3p PDZD2 -2.15518588554493 1.03390728226728e-23 0.614576516910267 0.000550427143916576 mirMAP;miRNATAP -0.105956988776729 0.00568707342923651 NA NA NA hsa-miR-10b-5p PDZD8 2.86931593037303 6.97409423207806e-23 -0.904735032238515 4.14855253310147e-09 MirTarget -0.104774686464624 2.08428134282672e-05 NA NA NA hsa-miR-144-3p PEA15 -2.97536914478815 6.00546047309683e-28 1.12311402840601 1.26777023794476e-31 mirMAP -0.138119269469802 1.43963601510596e-16 NA NA NA hsa-miR-139-5p PEG10 -2.11299531796557 8.16407076415038e-28 1.32430694329515 0.0306146820128554 mirMAP -0.622979909813308 1.44482527912386e-05 NA NA NA hsa-miR-3607-3p PEG10 -2.15518588554493 1.03390728226728e-23 1.32430694329515 0.0306146820128554 MirTarget;miRNATAP -0.322206039064698 0.0143811212176775 NA NA NA hsa-miR-139-5p PFDN6 -2.11299531796557 8.16407076415038e-28 0.844362110855891 3.77599962635258e-12 miRanda;miRNATAP -0.130166603376507 8.09109371835e-06 NA NA NA hsa-miR-139-5p PFKFB2 -2.11299531796557 8.16407076415038e-28 1.02845639301179 4.08475002850898e-12 miRanda -0.196796309772638 2.65108360902884e-08 NA NA NA hsa-miR-144-3p PFKFB2 -2.97536914478815 6.00546047309683e-28 1.02845639301179 4.08475002850898e-12 mirMAP -0.155740378915086 4.84276592505359e-10 NA NA NA hsa-miR-3607-3p PFKFB4 -2.15518588554493 1.03390728226728e-23 1.25161751152843 3.78691544751763e-10 mirMAP -0.194908065362168 7.21651155089466e-06 NA NA NA hsa-miR-424-5p PFKFB4 -2.62653257498508 2.38997974737991e-50 1.25161751152843 3.78691544751763e-10 MirTarget -0.202726160533719 4.44959869211136e-05 NA NA NA hsa-miR-139-5p PGBD1 -2.11299531796557 8.16407076415038e-28 0.831373466638705 1.41870436655856e-06 miRanda -0.215836678890405 1.06252637454667e-07 NA NA NA hsa-miR-139-5p PGM2L1 -2.11299531796557 8.16407076415038e-28 0.0325808937730736 0.823878768591522 PITA -0.110599386164985 0.0012839369371829 NA NA NA hsa-miR-199a-3p PGPEP1 -2.3279328685682 1.04468066198593e-17 0.167322965185669 0.143077647806586 mirMAP -0.117208622178761 1.13807850501199e-09 NA NA NA hsa-miR-199b-3p PGPEP1 -2.33226605401203 9.51887435273314e-18 0.167322965185669 0.143077647806586 mirMAP -0.117007526899486 1.18410731320233e-09 NA NA NA hsa-miR-424-5p PGPEP1 -2.62653257498508 2.38997974737991e-50 0.167322965185669 0.143077647806586 mirMAP -0.126748419910156 4.53935530211725e-06 NA NA NA hsa-miR-424-5p PHF19 -2.62653257498508 2.38997974737991e-50 1.31515412555065 1.20077313718174e-18 miRNATAP -0.158071873113296 2.98972794635409e-05 NA NA NA hsa-miR-139-5p PHTF2 -2.11299531796557 8.16407076415038e-28 0.479833616664147 1.04897601040811e-06 miRanda -0.16097248327491 1.67612959305233e-12 NA NA NA hsa-miR-199a-3p PHYHIPL -2.3279328685682 1.04468066198593e-17 0.875425421453594 0.00299276786748856 PITA -0.327282837795302 5.08319660780765e-11 NA NA NA hsa-miR-199b-3p PHYHIPL -2.33226605401203 9.51887435273314e-18 0.875425421453594 0.00299276786748856 PITA;miRNATAP -0.327161810018946 5.0013253601801e-11 NA NA NA hsa-miR-144-3p PI15 -2.97536914478815 6.00546047309683e-28 2.42014798732433 5.6014711887512e-09 MirTarget -0.300247598286138 2.01566006268664e-05 NA NA NA hsa-miR-3607-3p PI15 -2.15518588554493 1.03390728226728e-23 2.42014798732433 5.6014711887512e-09 mirMAP -0.416926860387133 3.57643295208967e-06 NA NA NA hsa-miR-424-5p PI4KB -2.62653257498508 2.38997974737991e-50 0.751391909069037 1.32868417915592e-20 miRNATAP -0.158304458130071 2.32199307478759e-15 NA NA NA hsa-miR-139-5p PIGZ -2.11299531796557 8.16407076415038e-28 0.879865611720272 3.11062927491165e-07 miRanda -0.231101331886694 1.12308000564738e-08 NA NA NA hsa-miR-17-5p PIK3CA 0.698861147045461 2.43854106455398e-05 -0.417502897789422 0.000144089141837096 miRNAWalker2_validate -0.140034439363479 1.22830047865626e-05 NA NA NA hsa-miR-339-5p PIK3CA 0.280589919878422 0.0355660282647215 -0.417502897789422 0.000144089141837096 miRanda -0.161250958910826 6.10867364493006e-05 NA NA NA hsa-miR-501-5p PIK3CA 1.15231083477882 2.98906150004088e-10 -0.417502897789422 0.000144089141837096 mirMAP -0.110297544989421 0.000121810192831398 NA NA NA hsa-miR-126-5p PIK3CB -0.428561469405594 6.6035585844222e-05 0.100967159570933 0.165951003911767 mirMAP -0.182730257201379 1.71015167377407e-08 NA NA NA hsa-miR-204-5p PIK3CB -0.537962150012103 0.0330895493358849 0.100967159570933 0.165951003911767 miRNATAP -0.108408817404481 9.83805003133513e-16 NA NA NA hsa-miR-32-5p PIK3CB 0.0806126674664016 0.548984992497432 0.100967159570933 0.165951003911767 miRNATAP -0.140663620385439 6.63155819716864e-08 NA NA NA hsa-miR-1468-5p PIK3CD -1.21475558175193 2.52286949987832e-09 -0.877858532886072 2.39332269929579e-06 MirTarget -0.114605918546385 0.00956114952826845 NA NA NA hsa-miR-30b-3p PIK3CD -0.439724365151373 0.000947180503583586 -0.877858532886072 2.39332269929579e-06 MirTarget -0.241027174305288 0.000454965508091255 NA NA NA hsa-miR-30d-5p PIK3CD 0.718283816348023 2.47422074061352e-08 -0.877858532886072 2.39332269929579e-06 MirTarget;miRNATAP -0.313277633599958 7.26196135533465e-06 NA NA NA hsa-miR-30e-5p PIK3CD -0.627815042856657 3.02205690184908e-10 -0.877858532886072 2.39332269929579e-06 MirTarget -0.253648851782905 0.00528999528593308 NA NA NA hsa-miR-616-5p PIK3CD 0.150569904638223 0.402836556304524 -0.877858532886072 2.39332269929579e-06 MirTarget -0.206581353665342 5.02538338243613e-05 NA NA NA hsa-miR-103a-3p PIK3R1 0.765568928457606 3.05497476509383e-12 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.187692597616198 0.00702590214654354 NA NA NA hsa-miR-106b-5p PIK3R1 0.648901865047099 8.24870862047885e-09 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.369244291882445 4.59379549667075e-08 NA NA NA hsa-miR-1301-3p PIK3R1 1.12156714169769 4.22404125385203e-10 -0.891953424131491 1.38465728969785e-08 MirTarget -0.26088137729301 3.97606431390706e-10 NA NA NA hsa-miR-132-3p PIK3R1 0.323796239695997 0.00272093067935091 -0.891953424131491 1.38465728969785e-08 MirTarget -0.517351445825174 2.17222827385203e-13 NA NA NA hsa-miR-15b-5p PIK3R1 0.230566941413564 0.0824765001857479 -0.891953424131491 1.38465728969785e-08 MirTarget -0.132325827339178 0.0249531550846148 NA NA NA hsa-miR-17-5p PIK3R1 0.698861147045461 2.43854106455398e-05 -0.891953424131491 1.38465728969785e-08 MirTarget;TargetScan;miRNATAP -0.213954808771155 3.8587060059728e-06 NA NA NA hsa-miR-185-5p PIK3R1 0.480006257154717 6.35758891340152e-07 -0.891953424131491 1.38465728969785e-08 miRNATAP -0.255181123475439 0.00153792085091181 NA NA NA hsa-miR-188-5p PIK3R1 1.11646899351496 9.56686958408598e-11 -0.891953424131491 1.38465728969785e-08 MirTarget -0.178093775716465 5.33015486626271e-05 NA NA NA hsa-miR-200c-3p PIK3R1 -0.104675615392797 0.716957669484981 -0.891953424131491 1.38465728969785e-08 mirMAP -0.105107802462856 9.06963579759966e-05 NA NA NA hsa-miR-20a-5p PIK3R1 0.854326758727003 5.04256669663285e-07 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.137431012149634 0.00237710222818209 NA NA NA hsa-miR-21-5p PIK3R1 1.51084295924322 1.54551622173259e-34 -0.891953424131491 1.38465728969785e-08 miRNAWalker2_validate;MirTarget;miRNATAP -0.626634426633867 6.01244523464713e-31 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-212-3p PIK3R1 -0.288359631986802 0.100392159518997 -0.891953424131491 1.38465728969785e-08 MirTarget -0.258090192317157 3.95293509038579e-09 NA NA NA hsa-miR-221-3p PIK3R1 1.12244756358612 3.48370308238012e-13 -0.891953424131491 1.38465728969785e-08 MirTarget -0.217914846238424 7.87055620620445e-06 NA NA NA hsa-miR-222-3p PIK3R1 1.08574156066353 1.76407192348131e-11 -0.891953424131491 1.38465728969785e-08 MirTarget -0.256619417997498 3.41697791848384e-08 NA NA NA hsa-miR-324-3p PIK3R1 0.260348469146494 0.0506141704203545 -0.891953424131491 1.38465728969785e-08 MirTarget;PITA;miRNATAP -0.281792149179102 1.26555231509763e-06 NA NA NA hsa-miR-330-3p PIK3R1 -0.332364259424489 0.0316051913061459 -0.891953424131491 1.38465728969785e-08 MirTarget;PITA;miRNATAP -0.212492102885122 3.44445995574159e-05 NA NA NA hsa-miR-338-5p PIK3R1 -0.221898432884726 0.252390988727086 -0.891953424131491 1.38465728969785e-08 PITA -0.143685656767977 0.000366657184559181 NA NA NA hsa-miR-409-3p PIK3R1 -0.499649792570937 0.0526751181520117 -0.891953424131491 1.38465728969785e-08 mirMAP -0.110448878014769 0.000237041711390918 NA NA NA hsa-miR-493-5p PIK3R1 -0.198321662045422 0.502870277689198 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.103739426368655 7.76271840065789e-05 NA NA NA hsa-miR-582-5p PIK3R1 -0.680189083316822 0.00103755166534107 -0.891953424131491 1.38465728969785e-08 mirMAP -0.138461163257927 0.00021364752999012 NA NA NA hsa-miR-589-3p PIK3R1 1.16846704028095 5.88525574424201e-11 -0.891953424131491 1.38465728969785e-08 mirMAP -0.21021578613876 1.13421126603334e-06 NA NA NA hsa-miR-590-5p PIK3R1 -0.103355559980404 0.310027295317092 -0.891953424131491 1.38465728969785e-08 MirTarget;PITA;miRanda;miRNATAP -0.299776876388425 9.9413226282672e-05 NA NA NA hsa-miR-629-3p PIK3R1 -0.315338123880353 0.119091248294946 -0.891953424131491 1.38465728969785e-08 MirTarget -0.182940394280375 3.19896248240917e-06 NA NA NA hsa-miR-93-5p PIK3R1 1.39518349670953 2.84167728726712e-25 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.319783065556515 2.89613370212511e-09 NA NA NA hsa-miR-126-3p PIK3R2 -0.652349350198172 9.37876280344772e-09 0.902461657566753 1.95242785807378e-14 miRNAWalker2_validate;miRTarBase -0.307009584408785 1.4469316595199e-09 25240815;26384552;27578985;21249429;26191164 MiR 126 3p suppresses tumor metastasis and angiogenesis of hepatocellular carcinoma by targeting LRP6 and PIK3R2; LRP6 and PIK3R2 were identified as targets of miR-126-3p; Silencing LRP6 and PIK3R2 had similar effects of miR-126-3p restoration on metastasis and angiogenesis individually in HCC cells; Furthermore the miR-126-3p level was inversely correlated with LRP6 and PIK3R2 in HCC tissues; In addition the rescue experiments indicated that the metastasis and angiogenesis functions of miR-126-3p were mediated by LRP6 and PIK3R2;MicroRNA 126 suppresses proliferation of undifferentiated BRAFV600E and BRAFWT thyroid carcinoma through targeting PIK3R2 gene and repressing PI3K AKT proliferation survival signalling pathway; In addition miR-126 was found to act as proliferation suppressor targeting PIK3R2 gene and reducing p85β a regulatory subunit of PI3K kinase protein translation and lower AKT kinase activity;MiR 126 regulates proliferation and invasion in the bladder cancer BLS cell line by targeting the PIK3R2 mediated PI3K/Akt signaling pathway; A direct regulatory relationship between miR-126 and the PIK3R2 gene was demonstrated by luciferase reporter assays; Quantitative real-time polymerase chain reaction was used to measure miR-126 and PIK3R2 expressions; Luciferase assays showed that miR-126 significantly inhibited the PIK3R2 3' untranslated region 3'UTR luciferase reporter activity P<0.05; Overexpression of miR-126 negatively regulated the target gene PIK3R2 and further inhibited the PI3K/Akt signaling pathway thereby inhibiting proliferation migration and invasion and promoting apoptosis in BLS cells;Endothelial specific intron derived miR 126 is down regulated in human breast cancer and targets both VEGFA and PIK3R2; VEGFA and PIK3R2 were confirmed as the targets of miR-126 by luciferase reporter assay and Western blot;Restoration of miR-126 in EC109 cells induced a reduction in PIK3R2 protein levels accompanied with a substantial reduction in phosphorylated AKT levels in EC109 cells suggesting impairment in PI3K/AKT signaling pathway; The luciferase reporter assay confirmed that PIK3R2 was a direct target of miR-126; Taken together our study suggests that miR-126 functions as a potential tumor suppressor in ESCC progression via regulating PI3K/AKT signaling pathway partly by targeting PIK3R2 and targeting of miR-126 may provide a novel strategy for the diagnosis and treatment of ESCC metastasis;poor survival;;;progression liver cancer;thyroid cancer;bladder cancer;breast cancer;esophageal cancer hsa-miR-28-5p PIK3R2 -0.430964830599964 2.67367257252925e-06 0.902461657566753 1.95242785807378e-14 miRanda -0.216513318430191 0.000794318920407844 NA NA NA hsa-miR-30a-5p PIK3R2 -0.626257932887855 0.000108198196973765 0.902461657566753 1.95242785807378e-14 miRNATAP -0.144672134574065 6.66511974688791e-05 NA NA NA hsa-miR-30e-5p PIK3R2 -0.627815042856657 3.02205690184908e-10 0.902461657566753 1.95242785807378e-14 miRNATAP -0.27051427660089 3.48529317139267e-06 NA NA NA hsa-miR-3607-3p PIK3R2 -2.15518588554493 1.03390728226728e-23 0.902461657566753 1.95242785807378e-14 mirMAP;miRNATAP -0.192639313478842 2.68262287342929e-14 NA NA NA hsa-miR-19a-3p PIK3R3 1.01712596153672 2.57753201450625e-07 0.635454203069077 2.81455381573105e-08 MirTarget;miRNATAP -0.104972668125809 0.000194207587349022 NA NA NA hsa-miR-19b-3p PIK3R3 0.601279551368824 0.00016685097085251 0.635454203069077 2.81455381573105e-08 MirTarget;miRNATAP -0.156884173334155 7.42851910353984e-06 NA NA NA hsa-miR-222-5p PIK3R3 0.125716360553359 0.487423909991138 0.635454203069077 2.81455381573105e-08 mirMAP -0.124074211713995 7.25281139850942e-05 NA NA NA hsa-miR-26b-5p PIK3R3 -1.10804856399744 4.14176110314282e-22 0.635454203069077 2.81455381573105e-08 miRNATAP -0.11879971388214 0.0117895234047857 NA NA NA hsa-miR-32-5p PIK3R3 0.0806126674664016 0.548984992497432 0.635454203069077 2.81455381573105e-08 MirTarget;miRNATAP -0.115094122727672 0.00654760226880116 NA NA NA hsa-miR-331-3p PIK3R3 -0.283974346994635 0.0373785411053202 0.635454203069077 2.81455381573105e-08 miRNAWalker2_validate;PITA -0.141431444954819 0.000659359723681179 NA NA NA hsa-miR-335-3p PIK3R3 -0.275199247483111 0.106629165248783 0.635454203069077 2.81455381573105e-08 mirMAP -0.159933987443154 1.18680673169693e-06 NA NA NA hsa-miR-454-3p PIK3R3 0.668749059573955 2.42670710515113e-06 0.635454203069077 2.81455381573105e-08 mirMAP -0.155284428603942 8.0835303918136e-05 NA NA NA hsa-miR-590-5p PIK3R3 -0.103355559980404 0.310027295317092 0.635454203069077 2.81455381573105e-08 miRanda -0.243402254613955 1.30668545381547e-05 NA NA NA hsa-miR-624-5p PIK3R3 -0.639533773668123 6.79146620944254e-06 0.635454203069077 2.81455381573105e-08 MirTarget -0.124942360560089 0.00156005977445166 NA NA NA hsa-miR-92a-3p PIK3R3 0.212391012518195 0.134292268089997 0.635454203069077 2.81455381573105e-08 MirTarget;miRNATAP -0.21036606255577 1.06004328001549e-07 NA NA NA hsa-miR-183-5p PIM1 2.33444328833177 1.52188109365421e-10 -1.03965437594354 8.81787316745957e-11 miRNATAP -0.140999567681768 1.54352845088907e-11 NA NA NA hsa-miR-139-5p PIP4K2B -2.11299531796557 8.16407076415038e-28 0.57569512577541 7.2526318631119e-15 miRanda -0.117193305106294 2.43328598381562e-11 NA NA NA hsa-miR-3607-3p PITX1 -2.15518588554493 1.03390728226728e-23 4.07775096376809 6.48992389749092e-14 mirMAP;miRNATAP -0.815835175692329 3.84318494111629e-12 NA NA NA hsa-miR-139-5p PITX2 -2.11299531796557 8.16407076415038e-28 0.732706410516242 0.0439037980226132 miRanda -0.489473425936468 6.88600285962409e-09 NA NA NA hsa-miR-483-3p PKD1L2 -2.99328900859484 2.67538108509603e-07 1.04791210772869 0.00406762580758537 mirMAP -0.177372097968823 3.16684643945486e-09 NA NA NA hsa-miR-3607-3p PKIA -2.15518588554493 1.03390728226728e-23 0.259803934002916 0.404559580397709 MirTarget -0.256610412594965 0.000112763819934872 NA NA NA hsa-miR-139-5p PKNOX1 -2.11299531796557 8.16407076415038e-28 0.273261190866287 6.48784120773265e-06 miRanda -0.102424478754929 1.76320937640652e-13 NA NA NA hsa-miR-338-3p PLA1A 0.543135607704581 0.00461167747143826 -0.998477900890527 3.37315615167909e-05 miRanda -0.130379616368577 0.034597019707027 NA NA NA hsa-miR-106b-5p PLA2G12A 0.648901865047099 8.24870862047885e-09 -0.791023748042462 1.18231931629012e-15 mirMAP -0.266014267647959 5.9212435860407e-10 NA NA NA hsa-miR-140-5p PLA2G12A -0.220106443070144 0.0140713197101242 -0.791023748042462 1.18231931629012e-15 miRanda -0.148237117501735 0.00839228705095135 NA NA NA hsa-miR-17-5p PLA2G12A 0.698861147045461 2.43854106455398e-05 -0.791023748042462 1.18231931629012e-15 mirMAP -0.156166087311117 1.18493997052615e-07 NA NA NA hsa-miR-181a-5p PLA2G12A 0.250113435902954 0.0551933249319293 -0.791023748042462 1.18231931629012e-15 mirMAP -0.193778811048191 3.19565578842397e-07 NA NA NA hsa-miR-181b-5p PLA2G12A 0.488256489401108 0.00105321129419701 -0.791023748042462 1.18231931629012e-15 mirMAP -0.187398478397273 1.16778168992629e-08 NA NA NA hsa-miR-20a-5p PLA2G12A 0.854326758727003 5.04256669663285e-07 -0.791023748042462 1.18231931629012e-15 mirMAP -0.130236012494097 5.73845333718432e-06 NA NA NA hsa-miR-32-3p PLA2G12A 0.219109440121582 0.207217051619543 -0.791023748042462 1.18231931629012e-15 mirMAP -0.100135809509177 0.000715271422667235 NA NA NA hsa-miR-362-3p PLA2G12A 0.814007335895913 2.00108618836568e-09 -0.791023748042462 1.18231931629012e-15 miRanda -0.13534064202416 0.000168490865417192 NA NA NA hsa-miR-501-5p PLA2G12A 1.15231083477882 2.98906150004088e-10 -0.791023748042462 1.18231931629012e-15 miRNATAP -0.159698924847702 1.1258030900796e-09 NA NA NA hsa-miR-589-3p PLA2G12A 1.16846704028095 5.88525574424201e-11 -0.791023748042462 1.18231931629012e-15 mirMAP -0.18597386225482 8.57790590041378e-12 NA NA NA hsa-miR-625-3p PLA2G12A 0.242249841316603 0.181227779755078 -0.791023748042462 1.18231931629012e-15 mirMAP -0.135161844446821 6.99056150075446e-07 NA NA NA hsa-miR-92b-3p PLA2G12A 0.220374930803974 0.296187538889092 -0.791023748042462 1.18231931629012e-15 miRNAWalker2_validate -0.10091652542866 1.70520826049974e-05 NA NA NA hsa-miR-93-5p PLA2G12A 1.39518349670953 2.84167728726712e-25 -0.791023748042462 1.18231931629012e-15 mirMAP -0.31642455552352 2.26982563682874e-21 NA NA NA hsa-miR-1976 PLA2G12B -0.431472440543166 0.00324575010550946 -0.709043082048637 0.0159106564464709 MirTarget -0.454863439085783 2.8222658320172e-06 NA NA NA hsa-miR-28-5p PLA2G1B -0.430964830599964 2.67367257252925e-06 1.11218092480272 0.00100002877020529 miRanda -0.522539189337601 0.00380748163736023 NA NA NA hsa-miR-361-5p PLA2G2A 0.233202959858696 0.00961572812255327 -2.63355537093474 0.000185160572420402 miRanda -2.32115808913069 1.20165686326271e-09 NA NA NA hsa-miR-30c-2-3p PLA2G2D -1.39811819128587 3.66376924527665e-15 -0.885146609200152 0.0330899260748063 mirMAP -0.308953568974045 0.00508340182787345 NA NA NA hsa-miR-33a-3p PLA2G4A -0.683025859637737 1.01106097756419e-05 -1.51782818803861 3.95172010500953e-09 MirTarget -0.193745815952464 0.0187047341103911 NA NA NA hsa-miR-361-5p PLA2G4A 0.233202959858696 0.00961572812255327 -1.51782818803861 3.95172010500953e-09 miRanda -0.519567336876991 0.000291415934911842 NA NA NA hsa-miR-362-3p PLA2G4A 0.814007335895913 2.00108618836568e-09 -1.51782818803861 3.95172010500953e-09 miRanda -0.270784488699881 0.0035520338530453 NA NA NA hsa-miR-374a-5p PLA2G4A 0.016390363747302 0.869784217438621 -1.51782818803861 3.95172010500953e-09 mirMAP -0.276584821629738 0.0333120371166889 NA NA NA hsa-miR-125b-5p PLA2G4F -1.35767721102906 1.16564617395164e-18 0.637297284760391 0.0471427063379242 miRNAWalker2_validate -0.437405494001312 6.28541540613338e-06 NA NA NA hsa-miR-128-3p PLA2G5 0.289735108018712 0.0114419474207889 -1.41944375217114 6.19629138768315e-10 miRNAWalker2_validate -0.27681378716713 0.00574201580029315 NA NA NA hsa-miR-361-5p PLA2G5 0.233202959858696 0.00961572812255327 -1.41944375217114 6.19629138768315e-10 miRanda -0.491895928491166 0.000117994720629655 NA NA NA hsa-miR-589-3p PLA2G5 1.16846704028095 5.88525574424201e-11 -1.41944375217114 6.19629138768315e-10 MirTarget -0.251533188441071 7.7546591228512e-05 NA NA NA hsa-miR-590-3p PLA2G5 -0.473167498047808 1.76652934637227e-05 -1.41944375217114 6.19629138768315e-10 miRanda;miRNATAP -0.266432269504883 0.0100884826912324 NA NA NA hsa-miR-590-5p PLA2G5 -0.103355559980404 0.310027295317092 -1.41944375217114 6.19629138768315e-10 miRanda -0.405592480648136 0.000336021206784067 NA NA NA hsa-miR-30a-3p PLA2G6 -1.52720594401486 1.3830066075708e-17 1.15734672432699 4.00326986916457e-16 miRNATAP -0.2445503962837 1.00180247722334e-10 NA NA NA hsa-miR-224-5p PLA2R1 2.67175249172213 1.46995328399796e-18 -2.07756523384901 1.3460586411591e-12 mirMAP -0.181965004666286 7.59444470386086e-05 NA NA NA hsa-miR-139-5p PLAG1 -2.11299531796557 8.16407076415038e-28 1.04276161449411 0.000370375517337123 PITA;mirMAP -0.195722644734342 0.00482284525861395 NA NA NA hsa-miR-144-3p PLAG1 -2.97536914478815 6.00546047309683e-28 1.04276161449411 0.000370375517337123 miRNAWalker2_validate;miRTarBase;miRNATAP -0.114495060986931 0.020513666804187 NA NA NA hsa-miR-199a-3p PLAG1 -2.3279328685682 1.04468066198593e-17 1.04276161449411 0.000370375517337123 PITA;miRNATAP -0.120678920255867 0.0173348175568722 NA NA NA hsa-miR-199b-3p PLAG1 -2.33226605401203 9.51887435273314e-18 1.04276161449411 0.000370375517337123 PITA;miRNATAP -0.12127159079604 0.0167100121542385 NA NA NA hsa-miR-3607-3p PLAG1 -2.15518588554493 1.03390728226728e-23 1.04276161449411 0.000370375517337123 miRNATAP -0.131059636408049 0.0383771647382902 NA NA NA hsa-miR-424-5p PLAG1 -2.62653257498508 2.38997974737991e-50 1.04276161449411 0.000370375517337123 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.177819925899293 0.0136798178293059 NA NA NA hsa-miR-3607-3p PLAGL2 -2.15518588554493 1.03390728226728e-23 0.336986331692996 0.00300478705110513 MirTarget;mirMAP;miRNATAP -0.136110709343989 1.46343178760078e-08 NA NA NA hsa-miR-139-5p PLAUR -2.11299531796557 8.16407076415038e-28 -0.875686346227218 2.89876634414617e-05 miRanda -0.166369184739737 0.000811117505885107 NA NA NA hsa-miR-139-5p PLBD1 -2.11299531796557 8.16407076415038e-28 -0.786482532599739 0.00426175307134143 miRanda -0.28043795259021 1.43531892617506e-05 NA NA NA hsa-miR-139-5p PLCB1 -2.11299531796557 8.16407076415038e-28 1.21243658346715 1.07604080006647e-07 miRanda -0.443285019092489 3.47497230555386e-17 NA NA NA hsa-miR-192-5p PLCE1 -0.50188499512787 0.00344713341196035 1.83443085070885 1.01603163205123e-17 miRNAWalker2_validate -0.326507983373389 1.74795253782827e-07 NA NA NA hsa-miR-215-5p PLCE1 -0.981544773246509 3.14452272477156e-05 1.83443085070885 1.01603163205123e-17 miRNAWalker2_validate -0.116910535149275 0.0105375816716153 NA NA NA hsa-miR-328-3p PLCE1 -0.547466865311955 6.8359574451572e-06 1.83443085070885 1.01603163205123e-17 MirTarget -0.326106391120481 0.000234152913793915 26773497 MiR 328 suppresses the survival of esophageal cancer cells by targeting PLCE1; Dual-luciferase reporter assay confirmed that miR-328 directly targeted phospholipase C epsilon 1 PLCE1 by binding to target sequences in the 3'-UTR; Additionally we found that miR-328 overexpression decreased PLCE1 mRNA and protein levels while miR-328 inhibition enhanced the PLCE1 expression; Further analysis showed that PLCE1 overexpression rescued the inhibitory effect of miR-328 on cell proliferation and invasion and repressed the promotive effect of miR-328 on cell apoptosis; In conclusion our results suggest that miR-328 suppresses the survival of EC cells by regulating PLCE1 expression which might be a potential therapeutic method for EC poor survival esophageal cancer hsa-miR-101-3p PLCG1 -1.48176407980989 3.98950707385704e-31 0.954675597841582 9.37413206548639e-17 miRNATAP -0.22440743759437 7.91378554146212e-08 NA NA NA hsa-miR-103a-2-5p PLD1 1.17085533927423 5.31418969120877e-09 -1.16313063789315 9.80903873525724e-10 MirTarget -0.101670614635446 0.037376633800889 NA NA NA hsa-miR-103a-3p PLD1 0.765568928457606 3.05497476509383e-12 -1.16313063789315 9.80903873525724e-10 MirTarget -0.26368174662399 0.00179962941800181 NA NA NA hsa-miR-107 PLD1 0.241662461253461 0.0170788899505389 -1.16313063789315 9.80903873525724e-10 MirTarget;miRanda -0.531659225145908 1.00907284646468e-08 NA NA NA hsa-miR-15a-5p PLD1 0.349521211668244 0.000770735998804736 -1.16313063789315 9.80903873525724e-10 MirTarget -0.380401161220259 2.87100002980444e-05 NA NA NA hsa-miR-32-3p PLD1 0.219109440121582 0.207217051619543 -1.16313063789315 9.80903873525724e-10 mirMAP -0.323216568494805 5.79568686466702e-09 NA NA NA hsa-miR-361-5p PLD1 0.233202959858696 0.00961572812255327 -1.16313063789315 9.80903873525724e-10 MirTarget;miRanda -0.546349921541104 1.99967621659251e-07 NA NA NA hsa-miR-374a-3p PLD1 -0.207171354826929 0.0623494608399903 -1.16313063789315 9.80903873525724e-10 MirTarget -0.244453974526287 0.00436706403835385 NA NA NA hsa-miR-374b-3p PLD1 -0.137420230218985 0.305318192448799 -1.16313063789315 9.80903873525724e-10 mirMAP -0.243103700943692 0.000607055622503843 NA NA NA hsa-miR-421 PLD1 0.941856334694081 6.12167297054077e-08 -1.16313063789315 9.80903873525724e-10 miRanda -0.163445356132813 0.00237837645921042 NA NA NA hsa-miR-664a-3p PLD1 0.485807855553031 0.000732553249798598 -1.16313063789315 9.80903873525724e-10 mirMAP -0.242144327959714 0.000215240480606375 NA NA NA hsa-miR-107 PLD2 0.241662461253461 0.0170788899505389 0.0167640292391766 0.859412665969709 miRanda -0.154618001633712 0.000692592099790345 NA NA NA hsa-miR-140-5p PLD2 -0.220106443070144 0.0140713197101242 0.0167640292391766 0.859412665969709 miRanda -0.173241486265709 0.000807835105099428 NA NA NA hsa-miR-139-5p PLEKHB2 -2.11299531796557 8.16407076415038e-28 0.00560086814314076 0.957822592701461 mirMAP -0.128345478962674 1.73799868435323e-07 NA NA NA hsa-miR-3607-3p PLEKHG2 -2.15518588554493 1.03390728226728e-23 1.10126051664067 3.21863245758859e-16 mirMAP -0.197410988109523 1.65433037920854e-11 NA NA NA hsa-miR-1269a PLEKHG4B 3.57543539205634 4.25369619949175e-08 0.790427207306621 0.0337710604622749 mirMAP -0.11089386582825 0.000107316802222788 NA NA NA hsa-miR-199a-3p PLEKHH1 -2.3279328685682 1.04468066198593e-17 1.25039195218202 7.83074573807631e-12 PITA;miRNATAP -0.110450909175182 0.000592022664689198 NA NA NA hsa-miR-199b-3p PLEKHH1 -2.33226605401203 9.51887435273314e-18 1.25039195218202 7.83074573807631e-12 PITA;miRNATAP -0.110590621412795 0.000577087342834573 NA NA NA hsa-miR-424-5p PLEKHH1 -2.62653257498508 2.38997974737991e-50 1.25039195218202 7.83074573807631e-12 miRNATAP -0.185620605716291 4.69691537990019e-05 NA NA NA hsa-miR-424-5p PLXDC1 -2.62653257498508 2.38997974737991e-50 2.83957658613902 7.43247270561304e-40 mirMAP -0.212425377736632 0.00023849852894372 NA NA NA hsa-miR-424-5p PLXNA2 -2.62653257498508 2.38997974737991e-50 0.670712916849495 3.85732284396182e-10 MirTarget;miRNATAP -0.144502343529187 4.15778341855781e-08 NA NA NA hsa-miR-3607-3p PLXNC1 -2.15518588554493 1.03390728226728e-23 1.44759435164552 0.000116169553345041 mirMAP;miRNATAP -0.349317821627493 1.45780279163163e-05 NA NA NA hsa-miR-3607-3p PM20D2 -2.15518588554493 1.03390728226728e-23 0.393991260145472 0.012621473539101 mirMAP -0.133239014863454 7.83852648471321e-05 NA NA NA hsa-miR-139-5p PNMA1 -2.11299531796557 8.16407076415038e-28 0.726696886986934 5.28913887977252e-07 miRanda -0.244144851658064 4.05414911163564e-13 NA NA NA hsa-miR-33b-5p PNMA1 -2.28852395459234 2.69046626645242e-22 0.726696886986934 5.28913887977252e-07 MirTarget -0.160554106598131 1.8442849007564e-08 NA NA NA hsa-miR-144-3p PODXL -2.97536914478815 6.00546047309683e-28 1.44094860371079 1.88695975215765e-18 MirTarget -0.183478522537795 7.17770182110247e-11 NA NA NA hsa-miR-139-5p POF1B -2.11299531796557 8.16407076415038e-28 -0.884150196518013 0.0655174131849482 MirTarget;miRanda -0.613177729577898 4.07124859231908e-08 NA NA NA hsa-miR-144-3p POGZ -2.97536914478815 6.00546047309683e-28 0.727229618149945 3.18900402177987e-14 miRNATAP -0.118057636359305 2.05884074794969e-13 NA NA NA hsa-miR-3607-3p POLQ -2.15518588554493 1.03390728226728e-23 3.12712016603278 5.47360218039726e-34 MirTarget -0.423345568513881 4.25018864300836e-13 NA NA NA hsa-miR-424-5p POLR3F -2.62653257498508 2.38997974737991e-50 0.522293533187991 9.23742705455141e-15 MirTarget;miRNATAP -0.120716534990699 2.30630371160598e-13 NA NA NA hsa-miR-139-5p POP1 -2.11299531796557 8.16407076415038e-28 0.725586980894877 5.6707197410918e-15 miRanda -0.202762983766 4.58345714754862e-21 NA NA NA hsa-miR-10b-3p PPARGC1A 2.77189254628215 2.26687582932628e-20 -1.91181447721978 1.53762022606371e-08 mirMAP -0.207863900170746 0.000290060988659042 NA NA NA hsa-miR-483-3p PPARGC1B -2.99328900859484 2.67538108509603e-07 -0.171170839113116 0.38344943912292 mirMAP -0.124458096311915 3.19526599171749e-15 NA NA NA hsa-miR-139-5p PPAT -2.11299531796557 8.16407076415038e-28 0.29832467661605 0.0032423733132547 miRanda -0.150578021252442 1.28891654771787e-10 NA NA NA hsa-miR-139-5p PPIH -2.11299531796557 8.16407076415038e-28 0.59557069002916 2.02197164704004e-08 miRanda -0.191919673167209 6.06641851085248e-15 NA NA NA hsa-miR-3607-3p PPP1R9A -2.15518588554493 1.03390728226728e-23 -0.189630957451167 0.529029203320251 MirTarget -0.155904954509597 0.0157460195702511 NA NA NA hsa-miR-139-5p PPP2R3A -2.11299531796557 8.16407076415038e-28 -0.234918525572345 0.207468150002507 miRanda -0.148444954911434 0.000695461265473248 NA NA NA hsa-miR-139-5p PRC1 -2.11299531796557 8.16407076415038e-28 3.32083015140916 5.44951738887043e-52 miRanda -0.740715595358915 5.37749641102427e-45 NA NA NA hsa-miR-199a-3p PRC1 -2.3279328685682 1.04468066198593e-17 3.32083015140916 5.44951738887043e-52 MirTarget -0.280453642080944 2.16928001293243e-11 NA NA NA hsa-miR-199b-3p PRC1 -2.33226605401203 9.51887435273314e-18 3.32083015140916 5.44951738887043e-52 MirTarget -0.280340670567541 2.13636746902576e-11 NA NA NA hsa-miR-139-5p PRDM15 -2.11299531796557 8.16407076415038e-28 1.01770549482425 1.33508593050756e-14 PITA;miRNATAP -0.218873267335472 3.05969360700999e-12 NA NA NA hsa-miR-3607-3p PRDM15 -2.15518588554493 1.03390728226728e-23 1.01770549482425 1.33508593050756e-14 mirMAP -0.19528423118365 8.19446951595735e-12 NA NA NA hsa-miR-1269a PRDM16 3.57543539205634 4.25369619949175e-08 -0.0350863855841362 0.920519496633606 mirMAP -0.144950399679336 5.89229245858342e-08 NA NA NA hsa-miR-144-3p PRDM16 -2.97536914478815 6.00546047309683e-28 -0.0350863855841362 0.920519496633606 MirTarget;miRNATAP -0.223007876756586 0.00014051523970993 NA NA NA hsa-miR-10b-3p PRICKLE2 2.77189254628215 2.26687582932628e-20 -1.36375835552812 1.67599789165395e-08 mirMAP -0.177808417675403 1.35390355995124e-05 NA NA NA hsa-miR-139-5p PRKAA2 -2.11299531796557 8.16407076415038e-28 0.910177606708893 0.0133266185680845 mirMAP -0.243840459298225 0.00500077362975578 NA NA NA hsa-miR-144-3p PRKAA2 -2.97536914478815 6.00546047309683e-28 0.910177606708893 0.0133266185680845 mirMAP -0.251212728741441 4.29127796324217e-05 NA NA NA hsa-miR-424-5p PRKAB2 -2.62653257498508 2.38997974737991e-50 0.56659891692032 3.41527340619955e-05 MirTarget -0.197064639630254 2.69560273561437e-09 NA NA NA hsa-miR-15b-5p PRKACA 0.230566941413564 0.0824765001857479 -0.366734298281574 0.000187937709098459 miRNATAP -0.152941432259851 2.28347891457603e-05 NA NA NA hsa-miR-374b-3p PRKACA -0.137420230218985 0.305318192448799 -0.366734298281574 0.000187937709098459 mirMAP -0.12450872310223 0.000539430321626312 NA NA NA hsa-miR-744-5p PRKACA -0.378868377317939 0.00125071229180016 -0.366734298281574 0.000187937709098459 miRNAWalker2_validate -0.115884324772662 0.0046979329289167 NA NA NA hsa-miR-17-5p PRKACB 0.698861147045461 2.43854106455398e-05 -0.439902334736784 5.50105175875769e-05 TargetScan -0.144472658686219 5.56449338176546e-06 NA NA NA hsa-miR-193a-3p PRKACB -0.117675551589896 0.309391958208578 -0.439902334736784 5.50105175875769e-05 miRanda -0.138772633279135 0.00285551569786557 NA NA NA hsa-miR-19b-3p PRKACB 0.601279551368824 0.00016685097085251 -0.439902334736784 5.50105175875769e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.115986971473871 0.00048141723506022 NA NA NA hsa-miR-93-5p PRKACB 1.39518349670953 2.84167728726712e-25 -0.439902334736784 5.50105175875769e-05 miRNAWalker2_validate -0.135496406586043 0.000297518311204663 NA NA NA hsa-miR-142-5p PRKCA -1.44575553250033 1.18797044680592e-13 0.662827897377551 1.5305893364122e-08 mirMAP -0.253211662252116 4.3295868991415e-20 NA NA NA hsa-miR-146a-5p PRKCA -0.742958238440575 0.000765983177482633 0.662827897377551 1.5305893364122e-08 mirMAP -0.137245496572864 1.03630471721186e-07 NA NA NA hsa-miR-150-5p PRKCA -1.14624309254329 1.51365525978726e-06 0.662827897377551 1.5305893364122e-08 mirMAP -0.222341791889769 1.93250353571038e-22 NA NA NA hsa-miR-181a-5p PRKCA 0.250113435902954 0.0551933249319293 0.662827897377551 1.5305893364122e-08 mirMAP -0.254408568412877 7.16377375327665e-09 NA NA NA hsa-miR-181b-5p PRKCA 0.488256489401108 0.00105321129419701 0.662827897377551 1.5305893364122e-08 mirMAP -0.205095445188407 8.90870928470555e-08 NA NA NA hsa-miR-181c-5p PRKCA -0.00639394152050299 0.969127212255928 0.662827897377551 1.5305893364122e-08 mirMAP -0.183322604105065 1.38074332954132e-07 NA NA NA hsa-miR-1976 PRKCA -0.431472440543166 0.00324575010550946 0.662827897377551 1.5305893364122e-08 miRNATAP -0.183056349310667 3.0318716310551e-06 NA NA NA hsa-miR-218-5p PRKCA -0.500091158894849 0.0398595700240766 0.662827897377551 1.5305893364122e-08 mirMAP -0.148170646737725 2.1349888993316e-10 NA NA NA hsa-miR-22-5p PRKCA -0.630365901263172 3.32415348030414e-05 0.662827897377551 1.5305893364122e-08 mirMAP -0.251052842185981 1.31444858545747e-11 NA NA NA hsa-miR-2355-3p PRKCA -0.471227472721651 0.00718598113738346 0.662827897377551 1.5305893364122e-08 mirMAP -0.157103097222143 1.75080235522893e-06 NA NA NA hsa-miR-24-2-5p PRKCA -0.570999109789414 0.000447358572601571 0.662827897377551 1.5305893364122e-08 miRNAWalker2_validate -0.215395057998791 6.57823794606976e-10 22911661 Preferential star strand biogenesis of pre miR 24 2 targets PKC alpha and suppresses cell survival in MCF 7 breast cancer cells poor survival breast cancer hsa-miR-29b-2-5p PRKCA -0.223258653034772 0.084306146519938 0.662827897377551 1.5305893364122e-08 mirMAP -0.18197054047472 4.89908312952123e-05 NA NA NA hsa-miR-330-3p PRKCA -0.332364259424489 0.0316051913061459 0.662827897377551 1.5305893364122e-08 mirMAP -0.210648698518416 2.68188227678048e-08 NA NA NA hsa-miR-381-3p PRKCA -1.11307533852141 4.70760087251745e-06 0.662827897377551 1.5305893364122e-08 mirMAP -0.100091563011784 1.9205952275757e-05 NA NA NA hsa-miR-450b-5p PRKCA -1.34333360369432 2.68386079790462e-17 0.662827897377551 1.5305893364122e-08 PITA;mirMAP;miRNATAP -0.224507062259025 6.89309401647265e-11 NA NA NA hsa-miR-495-3p PRKCA -0.751193061269953 0.00388779118736635 0.662827897377551 1.5305893364122e-08 mirMAP -0.103006977344404 3.01377161842223e-06 NA NA NA hsa-miR-505-3p PRKCA -1.20027021591555 1.27927500175937e-13 0.662827897377551 1.5305893364122e-08 miRNAWalker2_validate -0.100809044268482 0.00372474801967268 NA NA NA hsa-miR-654-3p PRKCA -1.72200544726291 6.91948971554614e-10 0.662827897377551 1.5305893364122e-08 mirMAP -0.104555302741979 1.91014801150244e-07 NA NA NA hsa-miR-194-5p PRKCB -0.292530160992458 0.0996141384876663 -1.62067363753233 3.76201992658756e-13 miRNATAP -0.310861421038956 6.51903986219064e-07 NA NA NA hsa-miR-23b-3p PRKCB -0.530561587109023 5.43807206823652e-07 -1.62067363753233 3.76201992658756e-13 mirMAP -0.286204121948097 0.00657996649038471 NA NA NA hsa-miR-30d-5p PRKCB 0.718283816348023 2.47422074061352e-08 -1.62067363753233 3.76201992658756e-13 mirMAP -0.362125630736335 2.22146697946039e-05 NA NA NA hsa-miR-340-5p PRKCB -0.00477614531381576 0.968502722773791 -1.62067363753233 3.76201992658756e-13 mirMAP -0.225497683155663 0.0158024495898231 NA NA NA hsa-miR-361-5p PRKCB 0.233202959858696 0.00961572812255327 -1.62067363753233 3.76201992658756e-13 MirTarget;miRanda;miRNATAP -0.424918272347972 0.000711090604030861 NA NA NA hsa-miR-589-3p PRKCB 1.16846704028095 5.88525574424201e-11 -1.62067363753233 3.76201992658756e-13 mirMAP -0.228692909978861 0.000252673885842927 NA NA NA hsa-miR-589-5p PRKCB 1.18593770505086 1.01781241960531e-22 -1.62067363753233 3.76201992658756e-13 mirMAP -0.552773953594914 1.64276000301029e-10 NA NA NA hsa-miR-616-5p PRKCB 0.150569904638223 0.402836556304524 -1.62067363753233 3.76201992658756e-13 mirMAP -0.245704989615516 7.89898683278172e-05 NA NA NA hsa-miR-664a-3p PRKCB 0.485807855553031 0.000732553249798598 -1.62067363753233 3.76201992658756e-13 mirMAP -0.348212449855556 6.35284546408206e-06 NA NA NA hsa-miR-424-5p PRMT7 -2.62653257498508 2.38997974737991e-50 0.190758081746663 0.0290208747561978 mirMAP -0.109636391116802 1.913811421107e-07 NA NA NA hsa-miR-139-5p PRPF3 -2.11299531796557 8.16407076415038e-28 0.94359206095613 3.92821639416103e-23 miRanda -0.199870475708964 1.36295759927715e-18 NA NA NA hsa-miR-139-5p PRR11 -2.11299531796557 8.16407076415038e-28 1.99211560684274 4.21699168750545e-09 miRanda -0.621912420509482 3.13396454970862e-15 NA NA NA hsa-miR-139-5p PRRT2 -2.11299531796557 8.16407076415038e-28 1.34759472909516 5.04177063186626e-12 miRanda -0.236282311557726 4.25571304302249e-07 NA NA NA hsa-miR-3607-3p PRRT2 -2.15518588554493 1.03390728226728e-23 1.34759472909516 5.04177063186626e-12 miRNATAP -0.273015068539869 8.67802902524978e-11 NA NA NA hsa-miR-139-5p PRRX1 -2.11299531796557 8.16407076415038e-28 2.13747637731194 2.98162416691034e-16 miRanda -0.413332770721526 4.20600441623531e-11 NA NA NA hsa-miR-144-3p PRRX1 -2.97536914478815 6.00546047309683e-28 2.13747637731194 2.98162416691034e-16 MirTarget -0.247066633301929 3.67426832432359e-08 NA NA NA hsa-miR-183-5p PSD3 2.33444328833177 1.52188109365421e-10 -1.20252145080477 1.19868322011977e-09 MirTarget -0.117755002401094 6.5248496979907e-06 NA NA NA hsa-miR-424-5p PSKH1 -2.62653257498508 2.38997974737991e-50 0.879428894611563 3.34327921284086e-17 MirTarget;miRNATAP -0.232868602287619 3.4419403283505e-20 NA NA NA hsa-miR-139-5p PSMD10 -2.11299531796557 8.16407076415038e-28 0.651164279616826 5.44861244737906e-17 miRanda -0.121799932016058 5.43310585449764e-11 NA NA NA hsa-miR-139-5p PSME3 -2.11299531796557 8.16407076415038e-28 0.496626137933335 2.95522663379897e-14 miRanda -0.126695040209955 8.59696277079642e-17 NA NA NA hsa-miR-139-5p PSPH -2.11299531796557 8.16407076415038e-28 1.24706279480923 1.25695070636676e-16 MirTarget;miRanda -0.326772511883147 1.68320146748925e-20 NA NA NA hsa-miR-139-5p PTGES3 -2.11299531796557 8.16407076415038e-28 0.41272841117159 5.12626222835943e-11 miRanda -0.129756837246569 2.09448370918419e-19 NA NA NA hsa-miR-144-3p PTGFRN -2.97536914478815 6.00546047309683e-28 0.507316306007716 0.00273384618681765 MirTarget;miRNATAP -0.143075381425298 3.6760032048053e-07 NA NA NA hsa-miR-10b-3p PTGS1 2.77189254628215 2.26687582932628e-20 -1.13535010371772 8.24439740770146e-07 mirMAP -0.212768926494698 3.26353725697036e-08 NA NA NA hsa-miR-139-5p PTHLH -2.11299531796557 8.16407076415038e-28 1.18418240379439 0.00181078859052455 miRanda -0.65575459178869 5.88525642650456e-14 NA NA NA hsa-miR-144-3p PTHLH -2.97536914478815 6.00546047309683e-28 1.18418240379439 0.00181078859052455 MirTarget -0.282328978701772 8.45868292734408e-06 NA NA NA hsa-miR-3607-3p PTPDC1 -2.15518588554493 1.03390728226728e-23 0.825072587179602 2.18217469677753e-10 mirMAP -0.115125436966393 4.71780395868132e-05 NA NA NA hsa-miR-181a-5p PTPN11 0.250113435902954 0.0551933249319293 -0.324998377632372 0.000647318034968802 miRNAWalker2_validate;miRTarBase -0.10436975560246 0.00355721073615052 NA NA NA hsa-miR-30d-3p PTPN11 -0.120562286038759 0.329549534782125 -0.324998377632372 0.000647318034968802 mirMAP -0.131571111343423 0.00049799614341566 NA NA NA hsa-miR-660-5p PTPN11 0.989755850734071 5.69930767464937e-14 -0.324998377632372 0.000647318034968802 mirMAP -0.110622431233159 0.00126771284106605 NA NA NA hsa-miR-33b-5p PTPRG -2.28852395459234 2.69046626645242e-22 0.490912263823608 0.00324856263309075 mirMAP -0.202574693190208 4.05941564501711e-10 NA NA NA hsa-miR-10b-3p PTPRT 2.77189254628215 2.26687582932628e-20 -1.89012666330824 4.99769771079087e-07 mirMAP -0.21560580295086 0.000703973839469471 NA NA NA hsa-miR-10b-5p PTPRT 2.86931593037303 6.97409423207806e-23 -1.89012666330824 4.99769771079087e-07 miRNAWalker2_validate;mirMAP -0.185312291529574 0.00208469656592859 NA NA NA hsa-miR-1269a PTPRT 3.57543539205634 4.25369619949175e-08 -1.89012666330824 4.99769771079087e-07 mirMAP -0.115788257020385 7.58401042000395e-05 NA NA NA hsa-miR-424-5p PXMP4 -2.62653257498508 2.38997974737991e-50 0.626458258235179 3.75424767991764e-08 MirTarget -0.182235975758742 4.32586546390359e-11 NA NA NA hsa-miR-424-5p PYCRL -2.62653257498508 2.38997974737991e-50 0.830809890342951 7.37352070902481e-10 mirMAP -0.24234302317355 1.27442944090222e-13 NA NA NA hsa-miR-1269a QSOX1 3.57543539205634 4.25369619949175e-08 -0.998176284579899 0.000345773632396881 mirMAP -0.170756713227239 3.09015670893304e-16 NA NA NA hsa-miR-144-3p RAB11FIP4 -2.97536914478815 6.00546047309683e-28 1.54437373311846 7.02562100479325e-17 mirMAP -0.259925281426951 5.7562994827869e-17 NA NA NA hsa-miR-3607-3p RAB11FIP4 -2.15518588554493 1.03390728226728e-23 1.54437373311846 7.02562100479325e-17 mirMAP -0.247798707207861 9.56924292978407e-10 NA NA NA hsa-miR-139-5p RAB11FIP5 -2.11299531796557 8.16407076415038e-28 0.00512755246580143 0.969958157879948 miRanda -0.124262736710879 9.54564262115744e-05 NA NA NA hsa-miR-10b-3p RAB27B 2.77189254628215 2.26687582932628e-20 -0.982992130812183 0.00316826721508081 mirMAP -0.233673666977326 2.64785426852171e-05 NA NA NA hsa-miR-3607-3p RAB3B -2.15518588554493 1.03390728226728e-23 2.31148128583348 9.51479131264821e-10 mirMAP -0.262137072842468 0.00150236260742143 NA NA NA hsa-miR-3607-3p RAB3D -2.15518588554493 1.03390728226728e-23 0.773304623493939 0.0020137981864917 mirMAP -0.231563129606124 1.52375172703557e-05 NA NA NA hsa-miR-330-5p RAB5B 0.442231058604099 0.0053308560843808 -0.0592972995689403 0.264583351509634 miRNATAP -0.112170529581912 8.42359256960935e-13 NA NA NA hsa-miR-144-3p RAB6B -2.97536914478815 6.00546047309683e-28 1.14011669130437 2.23537791600293e-14 mirMAP -0.156920922684318 5.97868903884692e-10 NA NA NA hsa-miR-3607-3p RAB6B -2.15518588554493 1.03390728226728e-23 1.14011669130437 2.23537791600293e-14 mirMAP -0.160230639827218 9.70452136655366e-07 NA NA NA hsa-miR-101-3p RAC1 -1.48176407980989 3.98950707385704e-31 0.216579201672401 0.00293326905874306 miRNAWalker2_validate;MirTarget -0.160619583159355 2.13421294167009e-10 25202416;24649082;25057058 In previous studies the role of miRNA-101 miR-101 in tumors has been identified as a tumor suppressor and until now the role of miR-101 and Rac1 in thyroid cancer has remained undefined; Rac1 was demonstrated to be negatively regulated by miR-101 at the post-transcriptional level via a specific target site within the 3' untranslated region by dual-luciferase reporter assay; The expression of Rac1 was also observed to inversely correlate with miR-101 expression in PTC tissues; knockdown of Rac1 by shRNA inhibited thyroid cancer cell migration and invasion resembling that of miR-101 overexpression; Thus these findings suggested that miR-101 acts as a novel suppressor by targeting the Rac1 gene and inhibiting thyroid cancer cell migration and invasion;miR 101 inhibits cell proliferation by targeting Rac1 in papillary thyroid carcinoma; In the present study we investigated the role of microRNA-101 miR-101 in PTC via targeting of Ras-related C3 botulinum toxin substrate 1 Rac1; Moreover algorithm-based and experimental strategies verified Rac1 as a direct target of miR-101 in the K1 cell line; Taken together these findings suggest that miR-101 inhibited PTC growth via the downregulation of Rac1 expression providing a better understanding of miRNA-modulated signaling networks for future cancer therapeutics;Mir-101 inhibitors significantly increased the luciferase activities of RAC1 3'UTR; Overexpression of mir-101 increased the expression of RAC1 while inhibition of mir-101 suppressed RAC1 expression; mir-101 can suppress RAC1 gene expression by targeting the specific sequence of RAC1 3'UTR cell migration;; thyroid cancer;thyroid cancer;colorectal cancer hsa-miR-193b-3p RAC2 -0.166697207281748 0.272022543069482 -0.540909479889968 0.00736745718035675 miRNAWalker2_validate -0.246231671968469 0.000150422998204956 NA NA NA hsa-miR-125a-5p RAC3 -0.91219969372382 1.38256246489548e-07 0.670983769148776 0.00109278799508602 PITA -0.323616313906469 9.94727754352694e-09 NA NA NA hsa-miR-342-3p RAC3 -0.319677314984262 0.0449813878317147 0.670983769148776 0.00109278799508602 miRanda -0.17569839241443 0.00542104916104601 NA NA NA hsa-miR-139-5p RACGAP1 -2.11299531796557 8.16407076415038e-28 2.47619748809122 3.80949763818893e-47 miRanda -0.558563490067813 3.92472756720583e-42 NA NA NA hsa-miR-139-5p RAD21 -2.11299531796557 8.16407076415038e-28 0.535354921594023 4.14289891566247e-08 miRanda -0.143025976760077 4.04070937342955e-10 NA NA NA hsa-miR-139-5p RAI1 -2.11299531796557 8.16407076415038e-28 0.299976497612845 0.0203059955454792 miRanda -0.14938374438128 7.30285856845529e-07 NA NA NA hsa-miR-139-5p RALA -2.11299531796557 8.16407076415038e-28 0.356889705448643 1.15054362861669e-08 miRanda -0.111262475186895 1.21402397168505e-14 NA NA NA hsa-miR-27b-3p RALA -0.823491817819754 9.20935302746823e-14 0.356889705448643 1.15054362861669e-08 miRNATAP -0.128080206262242 1.99992119450621e-06 NA NA NA hsa-miR-29a-3p RALA -0.856762511178136 4.65330336378459e-12 0.356889705448643 1.15054362861669e-08 miRNATAP -0.115857668164854 1.5056951112952e-06 NA NA NA hsa-miR-29c-3p RALA -1.4367517608807 1.61767774905781e-21 0.356889705448643 1.15054362861669e-08 miRNATAP -0.145205627535117 1.25874038751213e-14 NA NA NA hsa-miR-30e-3p RALA -1.20845647373031 3.10263633528203e-25 0.356889705448643 1.15054362861669e-08 MirTarget;miRNATAP -0.13176118164723 9.4848322953823e-08 NA NA NA hsa-miR-192-5p RALB -0.50188499512787 0.00344713341196035 -0.133157006154685 0.074563715411608 MirTarget -0.149704404771039 2.69040263284912e-13 NA NA NA hsa-miR-28-5p RALB -0.430964830599964 2.67367257252925e-06 -0.133157006154685 0.074563715411608 miRanda -0.130079809753146 0.000962141998853137 NA NA NA hsa-miR-374a-5p RALB 0.016390363747302 0.869784217438621 -0.133157006154685 0.074563715411608 mirMAP -0.176278253958307 1.19341680142967e-06 NA NA NA hsa-miR-19b-1-5p RALBP1 -0.277804782598538 0.0783067794722916 0.1698024329452 0.0449773531520714 mirMAP -0.107718420080393 3.35490340732313e-05 NA NA NA hsa-miR-139-5p RALGAPB -2.11299531796557 8.16407076415038e-28 0.406456513722963 3.27116240421948e-09 miRanda -0.103372806039744 1.22066205676705e-10 NA NA NA hsa-miR-139-5p RAP1GAP2 -2.11299531796557 8.16407076415038e-28 -0.150407243792527 0.591682167346389 mirMAP -0.137707608586337 0.0373099389883287 NA NA NA hsa-miR-144-3p RAP1GAP2 -2.97536914478815 6.00546047309683e-28 -0.150407243792527 0.591682167346389 mirMAP -0.102993421718238 0.0283554652529658 NA NA NA hsa-miR-107 RAPGEF5 0.241662461253461 0.0170788899505389 -0.422807580779549 0.0037816955397449 miRanda -0.403523871201451 7.87102134189385e-09 NA NA NA hsa-miR-148a-5p RAPGEF5 -0.767626696027761 1.08359477494797e-06 -0.422807580779549 0.0037816955397449 mirMAP -0.287010528373387 6.37631922430446e-11 NA NA NA hsa-miR-186-5p RAPGEF5 -0.060103391373687 0.535288717081205 -0.422807580779549 0.0037816955397449 mirMAP -0.215473744840938 0.00382721397478979 NA NA NA hsa-miR-29a-5p RAPGEF5 -0.113555908626946 0.349622266470788 -0.422807580779549 0.0037816955397449 mirMAP -0.228591688781472 0.000104563925591246 NA NA NA hsa-miR-33a-3p RAPGEF5 -0.683025859637737 1.01106097756419e-05 -0.422807580779549 0.0037816955397449 MirTarget -0.164498472433144 0.000316495334122282 NA NA NA hsa-miR-421 RAPGEF5 0.941856334694081 6.12167297054077e-08 -0.422807580779549 0.0037816955397449 miRanda -0.133738523326687 0.00096003510733513 NA NA NA hsa-miR-589-3p RAPGEF5 1.16846704028095 5.88525574424201e-11 -0.422807580779549 0.0037816955397449 mirMAP -0.110264671155234 0.00576017714375621 NA NA NA hsa-miR-21-5p RASA1 1.51084295924322 1.54551622173259e-34 -0.0728742068751655 0.561743113598097 miRNATAP -0.101935589192876 0.0258841950427365 25663768;27101583 RKO cells were transfected with vectors overexpressing or down-regulating either miR-21 or RASA1; Furthermore a luciferase reporter assay was used to determine whether RASA1 is a gene target of miR-21; RASA1 protein levels were significantly decreased in RKO cells compared with the other 5 colon cancer cell lines and RASA1 was confirmed as a target gene of miR-21; Interestingly RASA1 mRNA and protein levels in pre-miR-21-LV up-regulation of miR-21 cells were lower than those in anti-miR-21-LV down-regulation of miR-21 cells P < 0.05; RASA1 is a target gene of miR-21 which promotes malignant behaviors of RKO cells through regulation of RASA1 expression;Circulating MicroRNA 21 Is Involved in Lymph Node Metastasis in Cervical Cancer by Targeting RASA1; Then cervical cancer cell lines HeLa HPV-18 DNA E6/E7RNA and HT-3 HPV DNA E6/E7RNA were used to confirm the interaction between miR-21 and RASA1; MicroRNA-21 reduces RASA1 expression in cervical cancer cell lines and promotes cervical cancer cell migration via RASA1 malignant trasformation;metastasis;cell migration colon cancer;cervical and endocervical cancer hsa-miR-30b-5p RASA1 -0.54056186708617 2.44688760798341e-05 -0.0728742068751655 0.561743113598097 MirTarget -0.161690428976581 0.000636074752042687 NA NA NA hsa-miR-590-5p RASA1 -0.103355559980404 0.310027295317092 -0.0728742068751655 0.561743113598097 miRNATAP -0.145110092721134 0.0167882216064606 NA NA NA hsa-miR-17-5p RASA2 0.698861147045461 2.43854106455398e-05 -0.727100402961242 0.00330690041503877 TargetScan -0.188066123659572 0.00961646193374891 NA NA NA hsa-miR-30b-5p RASA2 -0.54056186708617 2.44688760798341e-05 -0.727100402961242 0.00330690041503877 mirMAP -0.20123856436322 0.0328767891660269 NA NA NA hsa-miR-30d-5p RASA2 0.718283816348023 2.47422074061352e-08 -0.727100402961242 0.00330690041503877 mirMAP -0.279104027154393 0.00262879281861428 NA NA NA hsa-miR-204-5p RASA3 -0.537962150012103 0.0330895493358849 -0.589768976876224 0.00186117684976835 MirTarget -0.186427219160849 2.8054492272899e-07 NA NA NA hsa-miR-101-3p RASA4 -1.48176407980989 3.98950707385704e-31 0.399517189809353 0.0293965025033579 mirMAP -0.178029432560402 0.00631900279012344 NA NA NA hsa-miR-194-3p RASA4 -0.772747277805343 2.9537465170191e-05 0.399517189809353 0.0293965025033579 mirMAP -0.175471031928771 0.000242509202100249 NA NA NA hsa-miR-616-3p RASA4 -0.699516741506971 1.82225985970292e-05 0.399517189809353 0.0293965025033579 mirMAP -0.112747533197982 0.0391695480818169 NA NA NA hsa-miR-616-5p RASA4 0.150569904638223 0.402836556304524 0.399517189809353 0.0293965025033579 MirTarget;mirMAP -0.110388029013474 0.0273852591360601 NA NA NA hsa-miR-28-5p RASAL1 -0.430964830599964 2.67367257252925e-06 -0.0671819044411079 0.87043298046523 miRanda -0.987558617223509 5.37400301373985e-06 NA NA NA hsa-miR-374b-3p RASAL1 -0.137420230218985 0.305318192448799 -0.0671819044411079 0.87043298046523 MirTarget -0.405539684380661 0.00710201328923342 NA NA NA hsa-miR-148a-5p RASAL2 -0.767626696027761 1.08359477494797e-06 0.540621829902408 6.96559685302098e-05 mirMAP -0.141560911902939 0.000713336309653822 NA NA NA hsa-miR-193a-3p RASAL2 -0.117675551589896 0.309391958208578 0.540621829902408 6.96559685302098e-05 miRanda -0.211457081232984 0.000258271385219833 NA NA NA hsa-miR-26b-3p RASAL2 -1.25503731613309 4.45390890119649e-27 0.540621829902408 6.96559685302098e-05 MirTarget -0.176420590554076 0.0010458027527562 NA NA NA hsa-miR-29a-3p RASAL2 -0.856762511178136 4.65330336378459e-12 0.540621829902408 6.96559685302098e-05 MirTarget -0.152413753493753 0.00380881245478701 NA NA NA hsa-miR-29b-1-5p RASAL2 -0.538946836809295 0.00102913307251186 0.540621829902408 6.96559685302098e-05 MirTarget -0.124993246409678 0.00202771761965569 NA NA NA hsa-miR-29b-3p RASAL2 -0.348885528720517 0.0121441341291285 0.540621829902408 6.96559685302098e-05 MirTarget -0.129229356499584 0.00713050980684886 NA NA NA hsa-miR-29c-3p RASAL2 -1.4367517608807 1.61767774905781e-21 0.540621829902408 6.96559685302098e-05 MirTarget -0.101619256255681 0.015904072299387 NA NA NA hsa-miR-30d-3p RASAL2 -0.120562286038759 0.329549534782125 0.540621829902408 6.96559685302098e-05 mirMAP -0.114541641245921 0.0352546589929551 NA NA NA hsa-miR-339-5p RASAL2 0.280589919878422 0.0355660282647215 0.540621829902408 6.96559685302098e-05 PITA -0.188077162289909 0.000165263938715403 NA NA NA hsa-miR-33a-3p RASAL2 -0.683025859637737 1.01106097756419e-05 0.540621829902408 6.96559685302098e-05 MirTarget;mirMAP -0.11902426653942 0.00545603016036312 NA NA NA hsa-miR-92a-3p RASAL2 0.212391012518195 0.134292268089997 0.540621829902408 6.96559685302098e-05 miRNAWalker2_validate -0.101546667262414 0.0317346643125376 NA NA NA hsa-miR-144-3p RASD2 -2.97536914478815 6.00546047309683e-28 2.400731696963 9.88874890802875e-33 miRNATAP -0.268730464419464 3.84259368328156e-14 NA NA NA hsa-miR-3607-3p RASD2 -2.15518588554493 1.03390728226728e-23 2.400731696963 9.88874890802875e-33 mirMAP -0.301404171057944 4.82387363168198e-11 NA NA NA hsa-miR-224-5p RASGEF1B 2.67175249172213 1.46995328399796e-18 -2.40154618069155 1.29739869332177e-25 mirMAP -0.13597523925383 0.000269288239401292 NA NA NA hsa-miR-139-3p RASGRF1 -2.53151940925585 1.56777509736867e-36 1.49106370660108 5.96975990261592e-05 MirTarget -0.163458535554656 0.0499233725105211 NA NA NA hsa-miR-195-5p RASGRF1 -1.85907534356434 1.47434041676402e-22 1.49106370660108 5.96975990261592e-05 mirMAP -0.26382335869635 0.00370723355782595 NA NA NA hsa-miR-326 RASGRF1 -1.881935132554 1.68087316863775e-21 1.49106370660108 5.96975990261592e-05 miRanda -0.182575076107047 0.0398539119818284 NA NA NA hsa-miR-331-5p RASGRF1 0.213759185384356 0.120772399478646 1.49106370660108 5.96975990261592e-05 miRNATAP -0.395652221732042 0.0030901408032086 NA NA NA hsa-miR-378c RASGRF1 -1.54028191929038 2.70131554214866e-15 1.49106370660108 5.96975990261592e-05 miRNATAP -0.248422441529015 0.00604478345599047 NA NA NA hsa-miR-491-5p RASGRF1 -0.369122930844418 0.0154047757048929 1.49106370660108 5.96975990261592e-05 miRanda -0.283876204998299 0.0192149756071952 NA NA NA hsa-miR-675-3p RASGRF1 -2.78074157259259 1.41541888062227e-14 1.49106370660108 5.96975990261592e-05 MirTarget -0.169385354363106 0.000496721731134416 NA NA NA hsa-miR-106b-5p RASGRF2 0.648901865047099 8.24870862047885e-09 1.67547187518086 9.26708186095625e-17 MirTarget -0.208847409796028 0.0201214966467345 NA NA NA hsa-miR-144-3p RASGRF2 -2.97536914478815 6.00546047309683e-28 1.67547187518086 9.26708186095625e-17 MirTarget -0.116232217149536 0.000902582927491765 NA NA NA hsa-miR-17-5p RASGRF2 0.698861147045461 2.43854106455398e-05 1.67547187518086 9.26708186095625e-17 MirTarget;TargetScan -0.160047261889063 0.00898560880561526 NA NA NA hsa-miR-28-5p RASGRF2 -0.430964830599964 2.67367257252925e-06 1.67547187518086 9.26708186095625e-17 miRanda -0.26943744273428 0.0157013796540736 NA NA NA hsa-miR-30d-3p RASGRF2 -0.120562286038759 0.329549534782125 1.67547187518086 9.26708186095625e-17 mirMAP -0.330098230904405 6.63464844250608e-05 NA NA NA hsa-miR-30e-3p RASGRF2 -1.20845647373031 3.10263633528203e-25 1.67547187518086 9.26708186095625e-17 mirMAP -0.174267447429212 0.0361329095937521 NA NA NA hsa-miR-324-5p RASGRF2 0.372933276649782 0.00592280066108904 1.67547187518086 9.26708186095625e-17 miRNATAP -0.241797869008385 0.00133113176196231 NA NA NA hsa-miR-3614-5p RASGRF2 -1.66311416965679 1.26647181860439e-15 1.67547187518086 9.26708186095625e-17 MirTarget -0.149342879539691 0.00183074151317134 NA NA NA hsa-miR-429 RASGRF2 -1.40262535827285 6.93982219171912e-05 1.67547187518086 9.26708186095625e-17 miRanda -0.159646288111756 2.56535359334375e-08 NA NA NA hsa-miR-590-3p RASGRF2 -0.473167498047808 1.76652934637227e-05 1.67547187518086 9.26708186095625e-17 MirTarget;miRanda -0.236921522005348 0.0104989881016831 NA NA NA hsa-miR-590-5p RASGRF2 -0.103355559980404 0.310027295317092 1.67547187518086 9.26708186095625e-17 miRanda -0.455005199224212 6.18498974335944e-06 NA NA NA hsa-miR-148a-3p RASGRP1 -0.748702855596996 3.93313343865641e-07 -0.453717444218552 0.0529724316830882 MirTarget -0.453369512761064 1.78337663608658e-09 NA NA NA hsa-miR-30d-3p RASGRP1 -0.120562286038759 0.329549534782125 -0.453717444218552 0.0529724316830882 MirTarget -0.208242886822546 0.0255607356360007 NA NA NA hsa-miR-28-5p RASGRP2 -0.430964830599964 2.67367257252925e-06 -0.74932696586711 0.000440761676884626 miRNATAP -0.275618114226164 0.0157420961512841 NA NA NA hsa-miR-940 RASGRP2 0.453020092551484 0.0177054921651997 -0.74932696586711 0.000440761676884626 MirTarget;PITA;miRNATAP -0.112592473308908 0.0459155476818704 NA NA NA hsa-miR-101-3p RASGRP3 -1.48176407980989 3.98950707385704e-31 0.366240287028941 0.0112314371168442 MirTarget -0.143683044248925 0.00513809938410704 NA NA NA hsa-miR-28-5p RASGRP3 -0.430964830599964 2.67367257252925e-06 0.366240287028941 0.0112314371168442 miRanda -0.18944040846486 0.0138425520911402 NA NA NA hsa-miR-324-3p RASGRP3 0.260348469146494 0.0506141704203545 0.366240287028941 0.0112314371168442 MirTarget -0.117789834890328 0.0268639068809379 NA NA NA hsa-miR-590-5p RASGRP3 -0.103355559980404 0.310027295317092 0.366240287028941 0.0112314371168442 miRanda -0.279983748673744 5.82948598319393e-05 NA NA NA hsa-miR-34a-5p RASGRP4 1.03694231790865 5.74864019540594e-14 -1.28007060385661 1.33669859072194e-14 MirTarget -0.130282311803738 0.0274425711105352 NA NA NA hsa-miR-616-5p RASGRP4 0.150569904638223 0.402836556304524 -1.28007060385661 1.33669859072194e-14 MirTarget -0.157811276275036 0.000713751663631576 NA NA NA hsa-miR-424-5p RASL12 -2.62653257498508 2.38997974737991e-50 2.22348331254447 5.19610169875086e-37 miRNATAP -0.182941819813484 8.79804683675288e-05 NA NA NA hsa-miR-542-3p RASSF1 -1.31351015149842 3.64642423288576e-22 0.655816117151532 9.89885092178326e-16 miRanda -0.10263601023261 0.000356102220108548 NA NA NA hsa-miR-107 RASSF5 0.241662461253461 0.0170788899505389 -0.908227788377981 1.02390034106228e-08 PITA;miRanda;miRNATAP -0.284285927003021 0.000267803442305389 NA NA NA hsa-miR-421 RASSF5 0.941856334694081 6.12167297054077e-08 -0.908227788377981 1.02390034106228e-08 miRanda -0.134754778124398 0.00257128215281031 NA NA NA hsa-miR-532-5p RASSF5 1.02729546510601 9.93318913966636e-16 -0.908227788377981 1.02390034106228e-08 PITA;miRNATAP -0.217078156594971 0.000253741557038178 NA NA NA hsa-miR-139-5p RBBP7 -2.11299531796557 8.16407076415038e-28 0.502046612529977 6.46813371549665e-13 miRanda -0.114104210549443 3.74341509072363e-12 NA NA NA hsa-miR-139-5p RBM17 -2.11299531796557 8.16407076415038e-28 0.280046243323731 1.1536984499294e-05 miRanda -0.100327240719824 9.55118159065318e-12 NA NA NA hsa-miR-139-5p RBM24 -2.11299531796557 8.16407076415038e-28 1.89188345491287 3.06626255996883e-11 miRanda -0.225863877313647 0.00100403847330336 NA NA NA hsa-miR-424-5p RBM4B -2.62653257498508 2.38997974737991e-50 0.379607806562966 3.58475815504451e-06 miRNAWalker2_validate -0.13087577288695 3.24638724136999e-11 NA NA NA hsa-miR-139-5p RBM8A -2.11299531796557 8.16407076415038e-28 0.426833182022193 6.35726485319414e-09 MirTarget;miRanda -0.107912511741927 3.60527376363174e-10 NA NA NA hsa-miR-10b-5p RBMS3 2.86931593037303 6.97409423207806e-23 -1.89502188938102 2.39783861807597e-18 MirTarget -0.13789790570866 0.000109543262999291 NA NA NA hsa-miR-1269a RBMS3 3.57543539205634 4.25369619949175e-08 -1.89502188938102 2.39783861807597e-18 MirTarget -0.100031459403558 5.96477477219141e-09 NA NA NA hsa-miR-139-5p RBX1 -2.11299531796557 8.16407076415038e-28 0.27440095690029 0.00162986680164289 miRanda -0.10537307725778 2.07264839791855e-07 NA NA NA hsa-miR-139-5p RCOR3 -2.11299531796557 8.16407076415038e-28 0.682612110290905 2.57158341609511e-13 miRanda -0.100224478323717 7.80287872635056e-06 NA NA NA hsa-miR-3607-3p RCOR3 -2.15518588554493 1.03390728226728e-23 0.682612110290905 2.57158341609511e-13 MirTarget -0.107241374298832 1.25903868412478e-07 NA NA NA hsa-miR-424-5p RCOR3 -2.62653257498508 2.38997974737991e-50 0.682612110290905 2.57158341609511e-13 MirTarget;miRNATAP -0.158373925383499 4.43058154857319e-12 NA NA NA hsa-miR-139-5p REG1B -2.11299531796557 8.16407076415038e-28 0.981488945182827 0.0298599334511247 miRanda -0.253830385230051 0.0174746361516756 NA NA NA hsa-miR-224-5p RELN 2.67175249172213 1.46995328399796e-18 -2.82839358389431 4.74435506980363e-07 MirTarget -0.270878865669266 0.0018905917611097 NA NA NA hsa-miR-139-5p RFC3 -2.11299531796557 8.16407076415038e-28 0.962948004313737 3.30946957694076e-14 miRanda -0.175133367532129 8.25050875678443e-09 NA NA NA hsa-miR-424-5p RFWD2 -2.62653257498508 2.38997974737991e-50 0.633010495593122 4.7570127100633e-15 MirTarget;miRNATAP -0.136010026133592 8.03393257116334e-12 NA NA NA hsa-miR-139-5p RFWD3 -2.11299531796557 8.16407076415038e-28 0.435632342748586 1.3132101658858e-06 miRanda -0.159236763644813 1.72936834697038e-14 NA NA NA hsa-miR-103a-2-5p RGL1 1.17085533927423 5.31418969120877e-09 -0.973948619416663 1.26483337600823e-11 MirTarget -0.100508684578738 0.00660129477184319 NA NA NA hsa-miR-106b-5p RGL1 0.648901865047099 8.24870862047885e-09 -0.973948619416663 1.26483337600823e-11 MirTarget;miRNATAP -0.383506094032223 6.11151737452188e-10 NA NA NA hsa-miR-17-5p RGL1 0.698861147045461 2.43854106455398e-05 -0.973948619416663 1.26483337600823e-11 MirTarget;TargetScan;miRNATAP -0.380332226200373 2.33568083251733e-20 NA NA NA hsa-miR-193a-3p RGL1 -0.117675551589896 0.309391958208578 -0.973948619416663 1.26483337600823e-11 miRNATAP -0.362794868052921 3.76900674213862e-09 NA NA NA hsa-miR-193a-5p RGL1 -0.472805720224262 1.24962968905481e-05 -0.973948619416663 1.26483337600823e-11 miRNATAP -0.181873958783537 0.006077109917019 NA NA NA hsa-miR-19a-3p RGL1 1.01712596153672 2.57753201450625e-07 -0.973948619416663 1.26483337600823e-11 MirTarget;miRNATAP -0.271352629266551 5.97690019667627e-15 NA NA NA hsa-miR-19b-3p RGL1 0.601279551368824 0.00016685097085251 -0.973948619416663 1.26483337600823e-11 MirTarget;miRNATAP -0.346750056186831 1.14800358840507e-15 NA NA NA hsa-miR-20a-5p RGL1 0.854326758727003 5.04256669663285e-07 -0.973948619416663 1.26483337600823e-11 MirTarget;miRNATAP -0.370894710581805 1.31087181871098e-20 NA NA NA hsa-miR-25-3p RGL1 0.633062563556379 3.68686354834328e-10 -0.973948619416663 1.26483337600823e-11 MirTarget -0.350585118683184 4.61367137776372e-07 NA NA NA hsa-miR-30d-5p RGL1 0.718283816348023 2.47422074061352e-08 -0.973948619416663 1.26483337600823e-11 miRNATAP -0.309640005692888 1.16837952047661e-08 NA NA NA hsa-miR-32-5p RGL1 0.0806126674664016 0.548984992497432 -0.973948619416663 1.26483337600823e-11 MirTarget -0.136676943886876 0.0109941629452671 NA NA NA hsa-miR-335-3p RGL1 -0.275199247483111 0.106629165248783 -0.973948619416663 1.26483337600823e-11 mirMAP -0.116048374313582 0.00594025388987099 NA NA NA hsa-miR-339-5p RGL1 0.280589919878422 0.0355660282647215 -0.973948619416663 1.26483337600823e-11 miRNATAP -0.190877170508384 0.000391865861771171 NA NA NA hsa-miR-455-5p RGL1 -0.270546034117157 0.0581320703577731 -0.973948619416663 1.26483337600823e-11 miRanda -0.237023712666923 2.14420252804157e-06 NA NA NA hsa-miR-616-5p RGL1 0.150569904638223 0.402836556304524 -0.973948619416663 1.26483337600823e-11 mirMAP -0.149992790356843 0.000173838259068644 NA NA NA hsa-miR-92a-3p RGL1 0.212391012518195 0.134292268089997 -0.973948619416663 1.26483337600823e-11 MirTarget -0.407790598212852 8.92453285028012e-17 NA NA NA hsa-miR-93-5p RGL1 1.39518349670953 2.84167728726712e-25 -0.973948619416663 1.26483337600823e-11 MirTarget;miRNATAP -0.378706750617305 1.02355623923204e-14 NA NA NA hsa-miR-142-3p RGL2 -1.4243101967815 1.92609481097765e-14 0.662505393800065 9.47215024955331e-11 miRanda;miRNATAP -0.122456232240795 3.13488470590986e-06 NA NA NA hsa-miR-27b-3p RGL2 -0.823491817819754 9.20935302746823e-14 0.662505393800065 9.47215024955331e-11 miRNATAP -0.120382501135317 0.00747149937726321 NA NA NA hsa-miR-144-3p RGMA -2.97536914478815 6.00546047309683e-28 1.61034636670118 7.04556214896046e-13 MirTarget -0.173571299668092 6.0811352878629e-06 NA NA NA hsa-miR-33b-5p RGS5 -2.28852395459234 2.69046626645242e-22 1.13782777301258 6.35983871996091e-09 mirMAP -0.139964503164929 0.000363688068960123 NA NA NA hsa-miR-139-5p RHBDL2 -2.11299531796557 8.16407076415038e-28 0.426860342350516 0.0550922341070744 miRanda -0.208616347462704 6.45281473897099e-05 NA NA NA hsa-miR-183-5p RHBDL3 2.33444328833177 1.52188109365421e-10 1.4613952794321 0.000215161782120482 mirMAP -0.219826730640173 1.99838782763735e-05 NA NA NA hsa-miR-183-5p RHOB 2.33444328833177 1.52188109365421e-10 -1.7358770639627 5.43143135520556e-23 miRNATAP -0.221090412916379 8.85138510305554e-22 NA NA NA hsa-miR-10b-3p RIC3 2.77189254628215 2.26687582932628e-20 -3.34879828365162 6.23343637087131e-20 mirMAP -0.371095503714221 4.51502701048447e-09 NA NA NA hsa-miR-193a-5p RIN1 -0.472805720224262 1.24962968905481e-05 0.393272717690683 0.0302485615178563 miRNATAP -0.316107456582193 0.000101637920974583 NA NA NA hsa-miR-361-5p RIN1 0.233202959858696 0.00961572812255327 0.393272717690683 0.0302485615178563 miRanda -0.33531500987886 0.000725290885542316 NA NA NA hsa-miR-139-5p RIT1 -2.11299531796557 8.16407076415038e-28 0.595574837085402 2.76047144897777e-12 miRanda -0.210082886328048 1.01283034646141e-27 NA NA NA hsa-miR-3607-3p RIT1 -2.15518588554493 1.03390728226728e-23 0.595574837085402 2.76047144897777e-12 mirMAP -0.110928553152908 1.55910459163561e-09 NA NA NA hsa-miR-224-5p RND3 2.67175249172213 1.46995328399796e-18 -2.63829715019045 8.05722959113031e-42 MirTarget -0.154278841556091 2.60782164813155e-06 NA NA NA hsa-miR-10b-5p RNF112 2.86931593037303 6.97409423207806e-23 -0.222586805042297 0.310570396820148 MirTarget -0.111070859451365 0.00133005817804711 NA NA NA hsa-miR-139-5p RNF144A -2.11299531796557 8.16407076415038e-28 0.810171087466595 2.5048912384854e-06 miRanda -0.244921970101679 1.21784827811821e-09 NA NA NA hsa-miR-3607-3p RNF144A -2.15518588554493 1.03390728226728e-23 0.810171087466595 2.5048912384854e-06 mirMAP -0.201456011794674 4.39068702005674e-08 NA NA NA hsa-miR-33b-5p RNF157 -2.28852395459234 2.69046626645242e-22 1.97473990741898 2.1201619720754e-12 mirMAP -0.144974485836041 0.0110799954802462 NA NA NA hsa-miR-10b-3p RNF165 2.77189254628215 2.26687582932628e-20 -3.06109685929762 4.74971186974903e-22 mirMAP -0.269293640507079 1.18100995847627e-06 NA NA NA hsa-miR-10b-5p RNF165 2.86931593037303 6.97409423207806e-23 -3.06109685929762 4.74971186974903e-22 MirTarget;miRNATAP -0.226001417102979 1.69199058466608e-05 NA NA NA hsa-miR-139-5p RNF2 -2.11299531796557 8.16407076415038e-28 0.170988054595251 0.153304732943593 PITA;miRanda -0.103112038681351 0.000237575375168675 NA NA NA hsa-miR-424-5p RNF43 -2.62653257498508 2.38997974737991e-50 0.784493664430453 0.00195272247858492 MirTarget;miRNATAP -0.402384975633418 3.82794793887818e-11 NA NA NA hsa-miR-183-5p RORA 2.33444328833177 1.52188109365421e-10 -1.18591701647076 1.08163415927424e-11 miRNATAP -0.173185029301672 2.0749060652837e-14 NA NA NA hsa-miR-139-5p RPIA -2.11299531796557 8.16407076415038e-28 0.596191356011587 2.32659407207361e-14 miRanda -0.147134380400274 8.99848312484696e-16 NA NA NA hsa-miR-139-5p RPL22L1 -2.11299531796557 8.16407076415038e-28 0.895289453131895 7.12301607869299e-06 miRanda -0.245365123151039 1.69593389664984e-07 NA NA NA hsa-miR-139-5p RPL23AP82 -2.11299531796557 8.16407076415038e-28 0.856139336156094 2.01952924862244e-14 miRanda -0.156488789880886 5.08255944965165e-09 NA NA NA hsa-miR-139-5p RPL37 -2.11299531796557 8.16407076415038e-28 0.436540875884313 0.000707292396155041 miRanda -0.150050492576166 6.62978976568847e-07 NA NA NA hsa-miR-139-5p RPS23 -2.11299531796557 8.16407076415038e-28 0.349606161596235 0.00249128780040517 miRanda -0.107053126054003 8.10023863706712e-05 NA NA NA hsa-miR-139-5p RPS27A -2.11299531796557 8.16407076415038e-28 0.317404543049338 0.006769012872385 miRanda -0.149797165024945 3.9685784460762e-08 NA NA NA hsa-miR-139-5p RPS3 -2.11299531796557 8.16407076415038e-28 0.394140079752983 0.000834768525344542 miRanda -0.150246050038684 4.78007716129745e-08 NA NA NA hsa-miR-424-5p RPS6KL1 -2.62653257498508 2.38997974737991e-50 1.9197850094522 6.91159342435759e-17 mirMAP -0.3143076880091 5.18168203814533e-08 NA NA NA hsa-miR-139-5p RPS7 -2.11299531796557 8.16407076415038e-28 0.465755681089079 4.25824545301515e-05 miRanda -0.166017273328949 3.6247770356077e-10 NA NA NA hsa-miR-424-5p RPUSD1 -2.62653257498508 2.38997974737991e-50 0.656610706544838 1.1310320311173e-11 mirMAP -0.133466012476409 2.18704996878137e-08 NA NA NA hsa-miR-139-5p RRAGD -2.11299531796557 8.16407076415038e-28 0.728091057482102 3.93159084114385e-05 MirTarget;miRanda -0.210462292303837 4.26413702961094e-07 NA NA NA hsa-miR-140-3p RRAS2 0.546012239205329 4.84578261098777e-11 -0.429270018876791 0.000197234745399743 MirTarget;PITA;miRNATAP -0.190567380807172 0.00472931315051582 NA NA NA hsa-miR-139-5p RTKN2 -2.11299531796557 8.16407076415038e-28 2.57925113894623 4.76198655776531e-18 miRanda -0.760177478341874 1.24397426836948e-28 NA NA NA hsa-miR-3607-3p RTKN2 -2.15518588554493 1.03390728226728e-23 2.57925113894623 4.76198655776531e-18 mirMAP -0.371995246827668 1.47316911290798e-08 NA NA NA hsa-miR-3607-3p RTN4R -2.15518588554493 1.03390728226728e-23 0.028501220232211 0.893029377082282 miRNATAP -0.116246450358115 0.0104117093685957 NA NA NA hsa-miR-10b-5p RUNDC3B 2.86931593037303 6.97409423207806e-23 -1.77231643639114 1.974302394488e-11 miRNAWalker2_validate -0.150570916388102 0.000422936479550916 NA NA NA hsa-miR-139-5p RUNX1 -2.11299531796557 8.16407076415038e-28 -0.00485952026487979 0.975956818735336 PITA;miRanda -0.148730739037456 8.08393097318912e-05 NA NA NA hsa-miR-139-5p S100PBP -2.11299531796557 8.16407076415038e-28 0.528107673830671 1.28764017908036e-09 miRanda -0.138413936726709 1.08217296270503e-11 NA NA NA hsa-miR-424-5p SAMD10 -2.62653257498508 2.38997974737991e-50 0.872932422756584 1.87788574518353e-13 MirTarget -0.198689263611568 9.67160920419293e-12 NA NA NA hsa-miR-10b-3p SAMD12 2.77189254628215 2.26687582932628e-20 -2.38933684023892 1.51021075610838e-11 mirMAP -0.31474755967145 1.61172774335444e-07 NA NA NA hsa-miR-183-5p SAMD4A 2.33444328833177 1.52188109365421e-10 -0.955832382695032 2.80164696716111e-12 MirTarget;miRNATAP -0.117473904964165 5.7121073073019e-11 NA NA NA hsa-miR-139-5p SARNP -2.11299531796557 8.16407076415038e-28 0.398521582380792 3.89712126026359e-06 miRanda -0.137970952324561 5.2791031762288e-12 NA NA NA hsa-miR-424-5p SATB2 -2.62653257498508 2.38997974737991e-50 0.52003541011141 0.00118691129677399 miRNATAP -0.131433484780334 0.000821775743590634 NA NA NA hsa-miR-3607-3p SBF1 -2.15518588554493 1.03390728226728e-23 1.06405585545956 5.63932142808997e-20 mirMAP;miRNATAP -0.170836285498757 2.15806315837445e-11 NA NA NA hsa-miR-139-5p SBK1 -2.11299531796557 8.16407076415038e-28 0.360418639058519 0.140066277820954 PITA;miRanda -0.242543548660297 2.22901692040122e-05 NA NA NA hsa-miR-199a-3p SCD -2.3279328685682 1.04468066198593e-17 -0.23960201269186 0.387988088797976 MirTarget;PITA;miRNATAP -0.156914356528907 0.000971436683306992 NA NA NA hsa-miR-199b-3p SCD -2.33226605401203 9.51887435273314e-18 -0.23960201269186 0.387988088797976 MirTarget;PITA;miRNATAP -0.156717137220448 0.000977681000875917 NA NA NA hsa-miR-139-5p SCG2 -2.11299531796557 8.16407076415038e-28 2.05291381366087 9.19914474865242e-11 miRanda -0.355261449512469 2.77194195866124e-06 NA NA NA hsa-miR-139-5p SCML2 -2.11299531796557 8.16407076415038e-28 1.10658718457286 8.54027458479512e-10 miRanda -0.188590833124406 1.20184207496013e-05 NA NA NA hsa-miR-3607-3p SCML2 -2.15518588554493 1.03390728226728e-23 1.10658718457286 8.54027458479512e-10 MirTarget -0.135818959596105 0.000557828738362661 NA NA NA hsa-miR-424-5p SCN4B -2.62653257498508 2.38997974737991e-50 0.905075675504791 1.19107448391954e-05 miRNATAP -0.157124116274995 0.00204871663250854 NA NA NA hsa-miR-3607-3p SCNM1 -2.15518588554493 1.03390728226728e-23 1.26965067234087 3.00027791390329e-25 miRNATAP -0.126078889968468 4.95668269445906e-06 NA NA NA hsa-miR-199a-3p SDC2 -2.3279328685682 1.04468066198593e-17 -0.03087902282995 0.814769949243076 MirTarget;PITA -0.115511834924422 2.30598186773853e-07 NA NA NA hsa-miR-199b-3p SDC2 -2.33226605401203 9.51887435273314e-18 -0.03087902282995 0.814769949243076 MirTarget;PITA;miRNATAP -0.115266174345604 2.40073191475098e-07 NA NA NA hsa-miR-33b-5p SEC14L5 -2.28852395459234 2.69046626645242e-22 0.311980940356044 0.259327528499545 mirMAP -0.17180814118499 0.00161126904134115 NA NA NA hsa-miR-424-5p SEC14L5 -2.62653257498508 2.38997974737991e-50 0.311980940356044 0.259327528499545 mirMAP -0.159895679383163 0.0181217195427074 NA NA NA hsa-miR-139-5p SEC22B -2.11299531796557 8.16407076415038e-28 0.8568778234032 0.04937100238036 miRanda -0.226746804229814 0.00249972646197349 NA NA NA hsa-miR-139-5p SEL1L3 -2.11299531796557 8.16407076415038e-28 -0.321740299766197 0.239676275511235 MirTarget;miRanda -0.321460123825538 4.63025162542107e-07 NA NA NA hsa-miR-424-5p SEMA5B -2.62653257498508 2.38997974737991e-50 2.17547526596525 2.66519103986908e-30 MirTarget -0.220260442961896 9.44934567997691e-06 NA NA NA hsa-miR-33b-5p SEMA7A -2.28852395459234 2.69046626645242e-22 1.19314988680133 1.05996526123706e-06 MirTarget;miRNATAP -0.213026648026437 1.13426892423644e-05 NA NA NA hsa-miR-424-5p SEMA7A -2.62653257498508 2.38997974737991e-50 1.19314988680133 1.05996526123706e-06 mirMAP -0.195714823523382 0.00120146309748206 NA NA NA hsa-miR-139-5p SEPT3 -2.11299531796557 8.16407076415038e-28 2.04173059346372 1.46360544494342e-11 PITA;miRanda -0.561433434064913 2.12816416256729e-15 NA NA NA hsa-miR-139-5p SEPT8 -2.11299531796557 8.16407076415038e-28 0.761947942489662 8.46348824111217e-18 miRanda -0.117489153272496 4.1356734681762e-08 NA NA NA hsa-miR-139-5p SERPINB1 -2.11299531796557 8.16407076415038e-28 0.257486490450793 0.0297665569301982 miRanda -0.182797843932975 2.11124545308677e-11 NA NA NA hsa-miR-224-5p SFMBT2 2.67175249172213 1.46995328399796e-18 -0.653813685456887 0.0100525670943711 mirMAP -0.106508246853308 0.00635667174467254 NA NA NA hsa-miR-139-5p SFPQ -2.11299531796557 8.16407076415038e-28 0.125568329226642 0.0568093957704412 miRanda -0.122030582846533 2.46654966874322e-16 NA NA NA hsa-miR-3607-3p SFRP4 -2.15518588554493 1.03390728226728e-23 2.13318024807939 8.83329524470029e-10 MirTarget -0.343276705360189 5.59321744727563e-06 NA NA NA hsa-miR-424-5p SFT2D3 -2.62653257498508 2.38997974737991e-50 0.352261169545839 5.22185267081055e-05 MirTarget -0.156941035561074 3.98884081185513e-14 NA NA NA hsa-miR-139-5p SFXN3 -2.11299531796557 8.16407076415038e-28 0.230740545201614 0.136862448159038 miRanda -0.179483686680514 6.83930959273328e-07 NA NA NA hsa-miR-183-5p SFXN5 2.33444328833177 1.52188109365421e-10 -0.609970038680049 3.38939795603913e-06 mirMAP -0.110294607668173 7.44862027744924e-11 NA NA NA hsa-miR-33b-5p SGIP1 -2.28852395459234 2.69046626645242e-22 0.504143685723322 0.057817349628702 mirMAP -0.129173182471871 0.0139390406151113 NA NA NA hsa-miR-139-5p SGTB -2.11299531796557 8.16407076415038e-28 0.0810874123995056 0.438106771519805 miRanda -0.105766449552138 1.4400861983352e-05 NA NA NA hsa-miR-183-5p SH3D19 2.33444328833177 1.52188109365421e-10 -0.821482116094042 8.83871291011707e-11 miRNAWalker2_validate;MirTarget -0.128312203666214 4.26975455522505e-15 NA NA NA hsa-miR-3607-3p SH3PXD2A -2.15518588554493 1.03390728226728e-23 0.416720664438486 0.000333370925413981 mirMAP;miRNATAP -0.139207531185338 1.594721254955e-08 NA NA NA hsa-miR-326 SHC1 -1.881935132554 1.68087316863775e-21 0.861944521276867 2.81146904648164e-19 miRanda -0.111062426734855 2.31350841693992e-06 NA NA NA hsa-miR-186-5p SHC2 -0.060103391373687 0.535288717081205 -0.454671061034392 0.0116778043545466 miRNAWalker2_validate -0.425744197135689 3.04991486566084e-06 NA NA NA hsa-miR-148a-3p SHC3 -0.748702855596996 3.93313343865641e-07 1.52510778944018 2.16327808412124e-07 MirTarget -0.266138626489331 0.00635514525014243 NA NA NA hsa-miR-27b-5p SHC3 -0.084323722931086 0.480868599074588 1.52510778944018 2.16327808412124e-07 MirTarget -0.618493226751706 3.36457282111212e-07 NA NA NA hsa-miR-331-5p SHC3 0.213759185384356 0.120772399478646 1.52510778944018 2.16327808412124e-07 PITA;miRNATAP -0.244398367417864 0.0220925831631148 NA NA NA hsa-miR-335-5p SHC3 -1.61347836513558 1.62757083289711e-19 1.52510778944018 2.16327808412124e-07 miRNAWalker2_validate -0.378086803358433 9.41082582721456e-07 NA NA NA hsa-miR-151a-3p SHC4 0.330888909161891 0.00418075524865448 -0.30528393131344 0.336531883601982 MirTarget -0.770437148358645 5.84261560379399e-09 NA NA NA hsa-miR-324-3p SHC4 0.260348469146494 0.0506141704203545 -0.30528393131344 0.336531883601982 PITA -0.377409630512375 0.00118711854225654 NA NA NA hsa-miR-106b-5p SHOC2 0.648901865047099 8.24870862047885e-09 -0.244908317010534 0.000294192744458335 MirTarget;miRNATAP -0.10887530082715 0.000158517260655332 NA NA NA hsa-miR-186-5p SHOC2 -0.060103391373687 0.535288717081205 -0.244908317010534 0.000294192744458335 miRNATAP -0.141247018695725 3.66302873268949e-05 NA NA NA hsa-miR-93-5p SHOC2 1.39518349670953 2.84167728726712e-25 -0.244908317010534 0.000294192744458335 MirTarget;miRNATAP -0.124888386309799 4.56426434000851e-08 NA NA NA hsa-miR-10b-3p SIGLEC1 2.77189254628215 2.26687582932628e-20 -1.61365637394439 7.58023495887356e-16 mirMAP -0.102237258808962 0.00322715789421555 NA NA NA hsa-miR-224-5p SIK1 2.67175249172213 1.46995328399796e-18 -1.56281900212212 2.20390485809155e-13 mirMAP -0.184351090000347 2.77939669990404e-08 NA NA NA hsa-miR-424-5p SIRT4 -2.62653257498508 2.38997974737991e-50 0.358155299054607 0.00343025114117995 MirTarget -0.180707832508039 8.39956764192875e-10 NA NA NA hsa-miR-139-5p SIX4 -2.11299531796557 8.16407076415038e-28 2.61579593202535 2.3706138390953e-15 miRanda -0.666080201085227 9.01110608546849e-18 NA NA NA hsa-miR-144-3p SIX4 -2.97536914478815 6.00546047309683e-28 2.61579593202535 2.3706138390953e-15 miRNATAP -0.286965724044458 4.18676895092909e-07 NA NA NA hsa-miR-33b-5p SIX4 -2.28852395459234 2.69046626645242e-22 2.61579593202535 2.3706138390953e-15 miRNATAP -0.348257458359801 1.83077954251533e-07 NA NA NA hsa-miR-424-5p SIX4 -2.62653257498508 2.38997974737991e-50 2.61579593202535 2.3706138390953e-15 miRNATAP -0.436943857725343 1.25973222535631e-07 NA NA NA hsa-miR-224-5p SLC14A1 2.67175249172213 1.46995328399796e-18 -1.49982946868094 2.66839496478096e-09 mirMAP -0.117675909221988 0.00279227961869833 NA NA NA hsa-miR-199a-3p SLC16A12 -2.3279328685682 1.04468066198593e-17 -0.582701560249782 0.124002938826254 MirTarget -0.233156647326153 0.000329208723212795 NA NA NA hsa-miR-199b-3p SLC16A12 -2.33226605401203 9.51887435273314e-18 -0.582701560249782 0.124002938826254 MirTarget -0.232952095884611 0.000329939951364375 NA NA NA hsa-miR-10b-3p SLC16A4 2.77189254628215 2.26687582932628e-20 -2.74677354708471 1.04691772940182e-18 MirTarget -0.290165241629392 6.59913890628267e-08 NA NA NA hsa-miR-199a-3p SLC1A2 -2.3279328685682 1.04468066198593e-17 -2.05184743338733 5.07102901300161e-06 PITA -0.226798871130317 0.00370756984748851 NA NA NA hsa-miR-199b-3p SLC1A2 -2.33226605401203 9.51887435273314e-18 -2.05184743338733 5.07102901300161e-06 PITA -0.226373957569862 0.00374785650292172 NA NA NA hsa-miR-224-5p SLC1A2 2.67175249172213 1.46995328399796e-18 -2.05184743338733 5.07102901300161e-06 mirMAP -0.326244862285761 2.35334796735804e-06 NA NA NA hsa-miR-3607-3p SLC22A23 -2.15518588554493 1.03390728226728e-23 0.632125395741205 5.61389746801226e-07 mirMAP;miRNATAP -0.116898032169237 1.74508206154689e-05 NA NA NA hsa-miR-424-5p SLC22A23 -2.62653257498508 2.38997974737991e-50 0.632125395741205 5.61389746801226e-07 mirMAP -0.174874835925763 1.35515942359791e-08 NA NA NA hsa-miR-183-5p SLC25A15 2.33444328833177 1.52188109365421e-10 -1.14546466496459 9.40317138852972e-08 MirTarget -0.168088006615094 1.78071341452801e-09 NA NA NA hsa-miR-183-5p SLC25A20 2.33444328833177 1.52188109365421e-10 -1.15436965250389 5.07894659968072e-16 MirTarget -0.154058680212022 1.04961040196928e-16 NA NA NA hsa-miR-139-5p SLC25A29 -2.11299531796557 8.16407076415038e-28 0.933926724345776 2.46355530693342e-13 miRanda -0.153490989011486 5.33897667966526e-07 NA NA NA hsa-miR-424-5p SLC25A35 -2.62653257498508 2.38997974737991e-50 0.822491182440289 3.92002124088498e-12 miRNATAP -0.11113368630657 0.000173360697185417 NA NA NA hsa-miR-139-5p SLC26A2 -2.11299531796557 8.16407076415038e-28 1.09398018681738 4.62078215884211e-18 mirMAP -0.222039584439244 1.8309419781564e-13 NA NA NA hsa-miR-183-5p SLC31A1 2.33444328833177 1.52188109365421e-10 -1.14463479413429 2.19129504521951e-22 miRNAWalker2_validate -0.119401060743604 2.69177490278678e-14 NA NA NA hsa-miR-139-5p SLC35F2 -2.11299531796557 8.16407076415038e-28 0.159271188425344 0.498013726122397 miRanda -0.230121076706577 2.85784302701637e-05 NA NA NA hsa-miR-33b-5p SLC36A1 -2.28852395459234 2.69046626645242e-22 1.00108743458475 1.1038952891858e-17 mirMAP -0.145252448426978 7.27096398591988e-10 NA NA NA hsa-miR-3607-3p SLC36A1 -2.15518588554493 1.03390728226728e-23 1.00108743458475 1.1038952891858e-17 miRNATAP -0.138191168735419 7.9804313608487e-08 NA NA NA hsa-miR-10b-5p SLC38A2 2.86931593037303 6.97409423207806e-23 -1.71612155888541 1.01671436925464e-27 miRNATAP -0.124235204993628 2.44095702523958e-06 NA NA NA hsa-miR-139-5p SLC39A1 -2.11299531796557 8.16407076415038e-28 0.676984930840535 1.23504219487475e-14 miRanda -0.193857117887379 1.21276031862617e-21 NA NA NA hsa-miR-144-3p SLC39A10 -2.97536914478815 6.00546047309683e-28 1.03363681046182 2.86152302488301e-10 miRNATAP -0.165395393161224 1.98654509507119e-09 NA NA NA hsa-miR-424-5p SLC39A13 -2.62653257498508 2.38997974737991e-50 0.702545531021421 5.82346425244418e-19 mirMAP -0.12193832404603 6.49936341415459e-10 NA NA NA hsa-miR-139-5p SLC39A6 -2.11299531796557 8.16407076415038e-28 0.306593085130331 0.00664663459623115 miRanda -0.150085403508106 1.06972818040658e-08 NA NA NA hsa-miR-139-5p SLC39A7 -2.11299531796557 8.16407076415038e-28 0.757033163977907 9.11383846934886e-16 miRanda -0.171119553053793 1.48528815645681e-14 NA NA NA hsa-miR-3607-3p SLC41A1 -2.15518588554493 1.03390728226728e-23 0.57556568860858 0.00174989031660913 miRNATAP -0.156858143879147 6.77670845276272e-05 NA NA NA hsa-miR-224-5p SLC4A4 2.67175249172213 1.46995328399796e-18 -2.23317622565422 7.81779722860372e-13 MirTarget -0.250426152573049 2.61465091344339e-07 NA NA NA hsa-miR-483-3p SLC4A4 -2.99328900859484 2.67538108509603e-07 -2.23317622565422 7.81779722860372e-13 mirMAP -0.126817596134131 1.61112148030486e-06 NA NA NA hsa-miR-139-5p SLC4A7 -2.11299531796557 8.16407076415038e-28 -0.103567361149529 0.538348902217845 miRanda -0.108243472922188 0.00625540593966653 NA NA NA hsa-miR-139-5p SLC4A8 -2.11299531796557 8.16407076415038e-28 0.213762758464392 0.268212349366514 miRanda -0.120488142157038 0.00804183705156762 NA NA NA hsa-miR-224-5p SLC5A3 2.67175249172213 1.46995328399796e-18 -1.14202730091157 9.93875965261116e-13 mirMAP -0.103987514767853 3.4102035148877e-05 NA NA NA hsa-miR-139-5p SLC6A14 -2.11299531796557 8.16407076415038e-28 0.804132473364506 0.0302945330917192 miRanda -0.497260174745725 8.3117803999188e-09 NA NA NA hsa-miR-10b-3p SLC6A20 2.77189254628215 2.26687582932628e-20 -1.97715671566768 5.53668624472399e-08 mirMAP -0.285127759477707 3.37989023505682e-06 NA NA NA hsa-miR-3607-3p SLC6A6 -2.15518588554493 1.03390728226728e-23 -0.096527667226542 0.716815862195345 MirTarget;miRNATAP -0.141226098884609 0.0132411482107856 NA NA NA hsa-miR-3607-3p SLC7A1 -2.15518588554493 1.03390728226728e-23 0.502718713769507 0.0648822874814592 mirMAP -0.163311750639897 0.00516229612643128 NA NA NA hsa-miR-144-3p SLC7A11 -2.97536914478815 6.00546047309683e-28 3.47167805920945 1.56674476751757e-19 miRNATAP -0.294674795884013 1.06747572618681e-05 NA NA NA hsa-miR-199b-3p SLC7A11 -2.33226605401203 9.51887435273314e-18 3.47167805920945 1.56674476751757e-19 miRNATAP -0.255181378265826 0.000211434512806285 NA NA NA hsa-miR-3607-3p SLC7A11 -2.15518588554493 1.03390728226728e-23 3.47167805920945 1.56674476751757e-19 miRNATAP -0.295925652098703 0.000583064547471829 NA NA NA hsa-miR-10b-3p SLFN13 2.77189254628215 2.26687582932628e-20 -0.628307489692556 0.0402974016169269 mirMAP -0.156786481133366 0.00222521852321332 NA NA NA hsa-miR-183-5p SLITRK3 2.33444328833177 1.52188109365421e-10 -5.61860150003464 8.77286424520162e-28 miRNATAP -0.24064564776231 0.000786912444081117 NA NA NA hsa-miR-424-5p SMAD3 -2.62653257498508 2.38997974737991e-50 0.313849246286883 0.00280528337161062 MirTarget -0.105846554796035 3.45471115916176e-05 27655675 miR 424 5p promotes proliferation of gastric cancer by targeting Smad3 through TGF β signaling pathway; QRT-PCR was used to determine the expression levels of miR-424-5p and Smad3; Luciferase reporter assay and western blotting were used to prove that Smad3 was one of the direct targets of miR-424-5p; In addition luciferase reporter assay and western blotting assay revealed that Smad3 was a direct target of miR-424-5p; Over-expression of Smad3 could partially reverse the effects of miR-424-5p on GC cell proliferation; Our study further revealed that miR-424-5p could inhibit TGF-β signaling pathway by Smad3 gastric cancer hsa-miR-139-5p SMARCA4 -2.11299531796557 8.16407076415038e-28 0.939839733482938 1.32567927001134e-26 PITA;miRanda;miRNATAP -0.225084992970389 1.32137701325748e-27 NA NA NA hsa-miR-144-3p SMARCA4 -2.97536914478815 6.00546047309683e-28 0.939839733482938 1.32567927001134e-26 miRNATAP -0.107060017463314 2.5697850687975e-12 NA NA NA hsa-miR-139-5p SMARCD1 -2.11299531796557 8.16407076415038e-28 0.643238619401545 1.43047276243426e-17 miRanda -0.21892037142305 5.15169668510699e-39 NA NA NA hsa-miR-424-5p SMARCD2 -2.62653257498508 2.38997974737991e-50 0.108275551344589 0.20709456021372 MirTarget;miRNATAP -0.107047071767411 2.14177589693801e-07 NA NA NA hsa-miR-139-5p SMC4 -2.11299531796557 8.16407076415038e-28 1.16163146348692 5.09379730864864e-18 miRanda -0.28253638318578 3.83166055514363e-19 NA NA NA hsa-miR-139-5p SMOX -2.11299531796557 8.16407076415038e-28 0.591532387697011 0.00577410816586931 miRNATAP -0.379388922979248 1.11227110566748e-14 NA NA NA hsa-miR-424-5p SMYD5 -2.62653257498508 2.38997974737991e-50 0.703671663920377 2.08776880698013e-14 miRNATAP -0.154929186983006 7.79846969047292e-12 NA NA NA hsa-miR-1269a SNAP25 3.57543539205634 4.25369619949175e-08 -0.0700982369377097 0.862359285781652 MirTarget -0.153424437340674 6.45447934908651e-07 NA NA NA hsa-miR-139-5p SNRPB -2.11299531796557 8.16407076415038e-28 1.09443368355559 2.09713766951328e-21 miRanda -0.306195664569648 7.26037474958714e-31 NA NA NA hsa-miR-139-5p SNRPE -2.11299531796557 8.16407076415038e-28 1.03768820293814 1.39601848132432e-19 miRanda -0.239434202819518 9.89497120633198e-19 NA NA NA hsa-miR-139-5p SNRPN -2.11299531796557 8.16407076415038e-28 -0.156948604661516 0.480190097714164 miRanda -0.144453554109585 0.00576168845006853 NA NA NA hsa-miR-424-5p SNX8 -2.62653257498508 2.38997974737991e-50 0.652527470677649 4.69592450906883e-10 mirMAP -0.108291617993127 2.99822500359163e-05 NA NA NA hsa-miR-139-5p SOCS7 -2.11299531796557 8.16407076415038e-28 1.23630045260618 2.28814323600538e-14 miRNATAP -0.297562060350442 6.68201659971497e-15 NA NA NA hsa-miR-10b-5p SORCS2 2.86931593037303 6.97409423207806e-23 -1.8024778697867 6.17372011882273e-06 mirMAP -0.167882218715056 0.00846213843913774 NA NA NA hsa-miR-144-3p SORT1 -2.97536914478815 6.00546047309683e-28 1.57067773298731 3.50162512345112e-17 mirMAP -0.185106495714458 7.12650717072076e-09 NA NA NA hsa-miR-33b-5p SORT1 -2.28852395459234 2.69046626645242e-22 1.57067773298731 3.50162512345112e-17 mirMAP -0.169435486017957 8.22794647380004e-06 NA NA NA hsa-miR-16-1-3p SOS1 0.392360028038559 0.00112481918108198 0.05751534180893 0.493041822065916 mirMAP -0.102425524653968 0.00242014805702593 NA NA NA hsa-miR-17-5p SOS1 0.698861147045461 2.43854106455398e-05 0.05751534180893 0.493041822065916 MirTarget;TargetScan;miRNATAP -0.11660606180243 1.37071072811905e-06 NA NA NA hsa-miR-193a-3p SOS1 -0.117675551589896 0.309391958208578 0.05751534180893 0.493041822065916 miRanda -0.167375491584816 1.83548073403882e-06 NA NA NA hsa-miR-20a-5p SOS1 0.854326758727003 5.04256669663285e-07 0.05751534180893 0.493041822065916 MirTarget;miRNATAP -0.100063123806167 2.02695724421345e-05 NA NA NA hsa-miR-27a-3p SOS1 -0.370807380415112 0.00875721956202713 0.05751534180893 0.493041822065916 MirTarget;miRNATAP -0.120226883007702 2.62552416504337e-05 NA NA NA hsa-miR-30b-5p SOS1 -0.54056186708617 2.44688760798341e-05 0.05751534180893 0.493041822065916 mirMAP -0.125950231468023 6.21375879766061e-05 NA NA NA hsa-miR-339-5p SOS1 0.280589919878422 0.0355660282647215 0.05751534180893 0.493041822065916 miRNATAP -0.15315814967207 4.05818038840081e-07 NA NA NA hsa-miR-590-5p SOS1 -0.103355559980404 0.310027295317092 0.05751534180893 0.493041822065916 miRanda -0.115356122634493 0.00426551999929742 NA NA NA hsa-miR-146b-5p SOS2 0.419719546795449 0.0457375823220155 -0.326258424146275 0.000900714126323724 miRanda -0.110125845201631 1.10330856080798e-06 NA NA NA hsa-miR-21-5p SOS2 1.51084295924322 1.54551622173259e-34 -0.326258424146275 0.000900714126323724 miRNATAP -0.279899776012046 7.56477883436428e-16 NA NA NA hsa-miR-590-5p SOS2 -0.103355559980404 0.310027295317092 -0.326258424146275 0.000900714126323724 PITA;miRanda;miRNATAP -0.144457452099512 0.00241614674200376 NA NA NA hsa-miR-3607-3p SOSTDC1 -2.15518588554493 1.03390728226728e-23 1.27401833583773 0.000581081669607043 MirTarget;miRNATAP -0.209607291352987 0.00868281837615802 NA NA NA hsa-miR-139-3p SOX11 -2.53151940925585 1.56777509736867e-36 1.40787252269122 1.13853242912301e-05 miRNATAP -0.504227492339627 6.33580445117539e-13 NA NA NA hsa-miR-144-3p SOX11 -2.97536914478815 6.00546047309683e-28 1.40787252269122 1.13853242912301e-05 miRNATAP -0.267877971584428 6.12239614707317e-07 NA NA NA hsa-miR-33b-5p SOX11 -2.28852395459234 2.69046626645242e-22 1.40787252269122 1.13853242912301e-05 miRNATAP -0.222016766146339 0.000499983531254934 NA NA NA hsa-miR-139-5p SOX2 -2.11299531796557 8.16407076415038e-28 0.957482238879068 0.017078375832613 miRanda -0.291129289569908 0.00211494818011014 NA NA NA hsa-miR-139-3p SOX4 -2.53151940925585 1.56777509736867e-36 0.747197754187451 0.00273773360761816 miRNATAP -0.336067993430686 7.53649279143943e-10 NA NA NA hsa-miR-10b-3p SOX6 2.77189254628215 2.26687582932628e-20 -2.13149609157814 4.50445986535194e-12 MirTarget;miRNATAP -0.314390657237216 1.52421706866232e-09 NA NA NA hsa-miR-199a-3p SP6 -2.3279328685682 1.04468066198593e-17 2.23551885984922 1.02825725864058e-20 miRNATAP -0.116108790551417 0.00729718895659468 NA NA NA hsa-miR-199b-3p SP6 -2.33226605401203 9.51887435273314e-18 2.23551885984922 1.02825725864058e-20 miRNATAP -0.116025947352098 0.00729686980598407 NA NA NA hsa-miR-139-5p SPA17 -2.11299531796557 8.16407076415038e-28 0.964677399350606 6.47295174390268e-08 mirMAP -0.228239785781685 6.17286323375827e-08 NA NA NA hsa-miR-139-5p SPAG1 -2.11299531796557 8.16407076415038e-28 -0.19328984154616 0.240342040643324 miRanda -0.122989696422681 0.00147505511318096 NA NA NA hsa-miR-139-5p SPATA17 -2.11299531796557 8.16407076415038e-28 0.670625412580457 0.0420481448904262 miRanda -0.404073628462938 1.48955359489613e-07 NA NA NA hsa-miR-139-5p SPEF2 -2.11299531796557 8.16407076415038e-28 0.777532612907956 5.17062457300754e-06 miRanda -0.190695955625201 2.17023465046847e-06 NA NA NA hsa-miR-3607-3p SPIN4 -2.15518588554493 1.03390728226728e-23 0.282634245218971 0.0688547961399822 MirTarget -0.110644466658761 0.000863139829890276 NA NA NA hsa-miR-139-5p SPOCK1 -2.11299531796557 8.16407076415038e-28 2.53504187150893 2.13962835594159e-10 PITA;miRanda;miRNATAP -0.423708309902778 9.21932166732659e-06 NA NA NA hsa-miR-139-5p SPP1 -2.11299531796557 8.16407076415038e-28 1.86706198200398 0.000286687598509149 miRanda -1.1519772014133 2.46405732226498e-23 NA NA NA hsa-miR-139-5p SQSTM1 -2.11299531796557 8.16407076415038e-28 0.814011499476504 1.06852369530173e-06 miRanda -0.183907674729959 3.1527582621112e-06 NA NA NA hsa-miR-144-3p SRC -2.97536914478815 6.00546047309683e-28 0.766173851969095 0.000257254769528933 MirTarget -0.131083807006654 0.000195420552491251 NA NA NA hsa-miR-139-5p SRD5A3 -2.11299531796557 8.16407076415038e-28 0.246242118761944 0.0239908283112069 miRanda -0.100398395264182 8.58310803923869e-05 NA NA NA hsa-miR-139-5p SRGAP1 -2.11299531796557 8.16407076415038e-28 0.526529645216711 0.00998247204415749 miRanda -0.139798323953895 0.00375800927032877 NA NA NA hsa-miR-3607-3p SRGAP1 -2.15518588554493 1.03390728226728e-23 0.526529645216711 0.00998247204415749 mirMAP;miRNATAP -0.107270161842721 0.0146316110345629 NA NA NA hsa-miR-10b-3p SRL 2.77189254628215 2.26687582932628e-20 -0.709345641602721 8.73318839614034e-05 mirMAP -0.131956017356163 1.29278326237933e-05 NA NA NA hsa-miR-424-5p SRPK1 -2.62653257498508 2.38997974737991e-50 0.546430300806312 9.51704538407861e-09 miRNATAP -0.108672801741182 3.50483217204563e-06 NA NA NA hsa-miR-139-5p SSH2 -2.11299531796557 8.16407076415038e-28 0.308455324497014 0.00122785737698821 miRanda -0.149331234093616 1.16091372524174e-11 NA NA NA hsa-miR-199a-3p SSX1 -2.3279328685682 1.04468066198593e-17 3.68205023967891 8.21303266394587e-08 miRNATAP -0.644265913343276 5.25312771958135e-08 NA NA NA hsa-miR-199b-3p SSX1 -2.33226605401203 9.51887435273314e-18 3.68205023967891 8.21303266394587e-08 miRNATAP -0.643955463075155 5.21380076652558e-08 NA NA NA hsa-miR-224-5p ST3GAL1 2.67175249172213 1.46995328399796e-18 -0.767532914178657 6.27233158530294e-05 mirMAP -0.115675520582939 8.71549914118953e-05 NA NA NA hsa-miR-183-5p ST6GALNAC3 2.33444328833177 1.52188109365421e-10 -1.04258541098903 2.10396558808448e-09 MirTarget -0.130602583803104 1.01016366405615e-08 NA NA NA hsa-miR-3607-3p ST6GALNAC5 -2.15518588554493 1.03390728226728e-23 1.02467419484144 0.00221288745533487 mirMAP -0.287516933642887 6.09582341368271e-05 NA NA NA hsa-miR-139-5p STC1 -2.11299531796557 8.16407076415038e-28 1.1939080061533 1.49954780653484e-08 miRanda -0.165705934361374 0.00102572036482671 NA NA NA hsa-miR-675-3p STC2 -2.78074157259259 1.41541888062227e-14 2.83254365450135 9.52717268651701e-29 MirTarget -0.165400351210154 2.74319354422837e-06 NA NA NA hsa-miR-139-5p STIL -2.11299531796557 8.16407076415038e-28 2.27606240799083 3.73674028972289e-36 miRanda -0.564523787819298 1.47359446780156e-40 NA NA NA hsa-miR-144-3p STIL -2.97536914478815 6.00546047309683e-28 2.27606240799083 3.73674028972289e-36 MirTarget -0.243227367157371 4.54474886710736e-14 NA NA NA hsa-miR-10b-5p STK33 2.86931593037303 6.97409423207806e-23 -1.07772305463957 0.00416196280350282 miRNAWalker2_validate -0.121939355215336 0.0414341558824037 NA NA NA hsa-miR-3607-3p STK35 -2.15518588554493 1.03390728226728e-23 0.639486866463096 6.71501847710025e-11 mirMAP;miRNATAP -0.130635142225124 5.38887811993209e-10 NA NA NA hsa-miR-424-5p STK35 -2.62653257498508 2.38997974737991e-50 0.639486866463096 6.71501847710025e-11 mirMAP -0.140779974203033 4.94764518919865e-09 NA NA NA hsa-miR-30b-3p STK4 -0.439724365151373 0.000947180503583586 -0.0242791347989213 0.739245017925932 MirTarget -0.106247080459235 5.60224295282278e-05 NA NA NA hsa-miR-30d-3p STK4 -0.120562286038759 0.329549534782125 -0.0242791347989213 0.739245017925932 mirMAP -0.132656583256455 3.19899840746635e-06 NA NA NA hsa-miR-139-5p STMN1 -2.11299531796557 8.16407076415038e-28 1.91204257620119 3.19032860888253e-31 miRanda -0.471061981941114 2.33045488589164e-34 NA NA NA hsa-miR-139-5p STRBP -2.11299531796557 8.16407076415038e-28 0.392025394535262 1.99600084597268e-06 miRanda;mirMAP -0.121200788703339 2.75574848245931e-10 NA NA NA hsa-miR-10b-3p STS 2.77189254628215 2.26687582932628e-20 -0.861172877158497 5.40693465418864e-06 mirMAP -0.108127109226387 0.000708477706985681 NA NA NA hsa-miR-424-5p STX1A -2.62653257498508 2.38997974737991e-50 1.55573478321698 4.09371979939195e-26 MirTarget -0.242202949939464 1.11915208937237e-10 NA NA NA hsa-miR-183-5p STX1B 2.33444328833177 1.52188109365421e-10 -0.640719876691996 0.00172836284903972 mirMAP -0.152093168415923 8.05665519687475e-09 NA NA NA hsa-miR-139-5p STXBP4 -2.11299531796557 8.16407076415038e-28 0.825288412971413 2.03775790430092e-09 miRanda -0.283425290438804 3.54086721827414e-19 NA NA NA hsa-miR-144-3p STXBP4 -2.97536914478815 6.00546047309683e-28 0.825288412971413 2.03775790430092e-09 mirMAP -0.137190598068633 2.8743321523856e-09 NA NA NA hsa-miR-139-5p STXBP5 -2.11299531796557 8.16407076415038e-28 0.144201694647037 0.31834936485805 miRanda -0.110373087998738 0.00113991598900121 NA NA NA hsa-miR-139-5p SUB1 -2.11299531796557 8.16407076415038e-28 0.583706814960803 1.03979976716946e-11 miRanda -0.168195388425999 2.90719241859112e-17 NA NA NA hsa-miR-33b-5p SULT4A1 -2.28852395459234 2.69046626645242e-22 0.999766279782465 0.0548748431251418 mirMAP -0.235745251474944 0.0221434013720822 NA NA NA hsa-miR-139-5p SYN3 -2.11299531796557 8.16407076415038e-28 1.70605931101855 1.57346532914891e-09 miRanda -0.208033982375117 0.00218298849629782 NA NA NA hsa-miR-101-3p SYNGAP1 -1.48176407980989 3.98950707385704e-31 0.236751509559486 0.0747028826209226 miRNATAP -0.171078363550902 0.000269323721594251 NA NA NA hsa-miR-1269a SYNGR1 3.57543539205634 4.25369619949175e-08 -0.0467874970365392 0.881901328445337 mirMAP -0.101452832394495 2.57531756144745e-05 NA NA NA hsa-miR-3607-3p SYNJ2 -2.15518588554493 1.03390728226728e-23 0.152738589872901 0.377287055436838 MirTarget;miRNATAP -0.115267088590955 0.00182060392542159 NA NA NA hsa-miR-10b-3p SYT13 2.77189254628215 2.26687582932628e-20 -2.45567389483829 3.10650606083992e-06 mirMAP -0.585310912297006 1.89565438711597e-11 NA NA NA hsa-miR-139-5p SYT13 -2.11299531796557 8.16407076415038e-28 -2.45567389483829 3.10650606083992e-06 miRanda -0.334974857481822 0.00765983198145931 NA NA NA hsa-miR-139-3p SYT2 -2.53151940925585 1.56777509736867e-36 0.802467229345947 0.00243072866414651 miRNATAP -0.139752067599905 0.0180128746582138 NA NA NA hsa-miR-3607-3p SYT2 -2.15518588554493 1.03390728226728e-23 0.802467229345947 0.00243072866414651 mirMAP;miRNATAP -0.251083281897734 8.98646444067871e-06 NA NA NA hsa-miR-139-3p SYT8 -2.53151940925585 1.56777509736867e-36 0.693368757624048 0.140379803925322 miRNATAP -0.680572655216857 2.74759627698046e-11 NA NA NA hsa-miR-139-5p TAF1A -2.11299531796557 8.16407076415038e-28 1.10990755947388 2.81571857158137e-12 miRanda -0.188862213519915 6.95766417012494e-07 NA NA NA hsa-miR-139-5p TAF4 -2.11299531796557 8.16407076415038e-28 0.357240152713125 3.41223777620266e-05 miRanda -0.113371855346396 1.73214974063264e-08 NA NA NA hsa-miR-424-5p TAF5 -2.62653257498508 2.38997974737991e-50 0.389205133880753 4.64864126412305e-06 miRNATAP -0.101152165835862 1.03889708838738e-06 NA NA NA hsa-miR-139-5p TAP2 -2.11299531796557 8.16407076415038e-28 0.593434452577685 8.73936906039817e-06 miRanda -0.12156464703318 0.000119338429220765 NA NA NA hsa-miR-424-5p TBC1D13 -2.62653257498508 2.38997974737991e-50 0.861209565504011 9.70398365961959e-16 MirTarget -0.236818570635247 7.00412621828088e-20 NA NA NA hsa-miR-424-5p TBC1D16 -2.62653257498508 2.38997974737991e-50 1.09783247128337 3.62886274986965e-17 MirTarget -0.199910201701022 8.02671958940721e-10 NA NA NA hsa-miR-10b-3p TC2N 2.77189254628215 2.26687582932628e-20 -0.469106444994978 0.158811311067363 MirTarget -0.178936577275274 0.00128935356567961 NA NA NA hsa-miR-139-5p TCF19 -2.11299531796557 8.16407076415038e-28 2.65870277963233 3.13566995363328e-39 miRanda -0.5821873463146 6.44067648745641e-33 NA NA NA hsa-miR-139-5p TCF3 -2.11299531796557 8.16407076415038e-28 0.998940019737234 2.89327015478546e-22 PITA;miRanda -0.277394557721886 1.02539476106278e-31 NA NA NA hsa-miR-421 TEK 0.941856334694081 6.12167297054077e-08 -2.10076794618928 8.11230955920562e-16 miRanda -0.557873847597563 1.84056043955124e-14 NA NA NA hsa-miR-455-5p TEK -0.270546034117157 0.0581320703577731 -2.10076794618928 8.11230955920562e-16 miRanda -0.236378289508641 0.0107994190329021 NA NA NA hsa-miR-139-5p TES -2.11299531796557 8.16407076415038e-28 0.395811347102818 0.0185114213990656 miRanda -0.1651125235301 2.79888178394005e-05 NA NA NA hsa-miR-139-5p TET3 -2.11299531796557 8.16407076415038e-28 0.533638199982642 5.07505640934234e-06 miRanda -0.130546803742011 2.18500083982948e-06 NA NA NA hsa-miR-139-3p TFAP2A -2.53151940925585 1.56777509736867e-36 1.04765785650872 0.00261483520532383 miRNATAP -0.485109806239164 1.84486794339597e-10 NA NA NA hsa-miR-10b-3p TFAP2C 2.77189254628215 2.26687582932628e-20 -0.887477715336118 0.015762727382329 MirTarget -0.23320234045355 0.000145218341983853 NA NA NA hsa-miR-10b-5p TFAP2C 2.86931593037303 6.97409423207806e-23 -0.887477715336118 0.015762727382329 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.200031808259974 0.000574865628019041 NA NA NA hsa-miR-424-5p TFAP4 -2.62653257498508 2.38997974737991e-50 0.620275429911324 1.0228576574331e-09 miRNATAP -0.138986257933207 2.4764170223868e-08 NA NA NA hsa-miR-3607-3p TFCP2L1 -2.15518588554493 1.03390728226728e-23 0.0691205247491691 0.814888444830697 mirMAP -0.204005447480686 0.00122154766421197 NA NA NA hsa-miR-144-3p TFRC -2.97536914478815 6.00546047309683e-28 0.937052448042543 3.46645820917872e-11 miRNATAP -0.136397744611933 1.12630892189876e-08 NA NA NA hsa-miR-140-3p TGFA 0.546012239205329 4.84578261098777e-11 -2.03762583735332 1.70833612877746e-11 miRNATAP -1.3315760430671 3.4498293194206e-14 NA NA NA hsa-miR-148a-3p TGFA -0.748702855596996 3.93313343865641e-07 -2.03762583735332 1.70833612877746e-11 miRNATAP -0.794888513212377 5.2082388955199e-16 NA NA NA hsa-miR-28-5p TGFA -0.430964830599964 2.67367257252925e-06 -2.03762583735332 1.70833612877746e-11 miRanda -0.350778371742809 0.0340263588113523 NA NA NA hsa-miR-29a-5p TGFA -0.113555908626946 0.349622266470788 -2.03762583735332 1.70833612877746e-11 mirMAP -0.252615560837573 0.0447814179770362 NA NA NA hsa-miR-33a-3p TGFA -0.683025859637737 1.01106097756419e-05 -2.03762583735332 1.70833612877746e-11 mirMAP -0.234353155050535 0.0160879629955182 NA NA NA hsa-miR-452-5p TGFA 1.91544498799508 1.81995982853313e-14 -2.03762583735332 1.70833612877746e-11 mirMAP -0.198820467771802 0.000663801168626612 NA NA NA hsa-miR-92a-3p TGFA 0.212391012518195 0.134292268089997 -2.03762583735332 1.70833612877746e-11 miRNAWalker2_validate -0.228519814447389 0.0332900137831131 NA NA NA hsa-miR-139-5p TGFB1 -2.11299531796557 8.16407076415038e-28 0.0791820105139553 0.6886056388594 miRanda -0.165335310650966 0.000359864512900183 NA NA NA hsa-miR-139-5p TGIF2 -2.11299531796557 8.16407076415038e-28 0.183370689181392 0.147188585278003 miRanda -0.142885972824944 1.24628638680886e-06 NA NA NA hsa-miR-139-5p THOC2 -2.11299531796557 8.16407076415038e-28 0.517010812603893 2.04819609899759e-09 miRanda -0.105022740454265 2.68455130716789e-07 NA NA NA hsa-miR-106b-5p TIAM1 0.648901865047099 8.24870862047885e-09 -1.56411477781397 6.02866811798354e-13 MirTarget;miRNATAP -0.618343970733846 4.25708816469882e-11 NA NA NA hsa-miR-1266-5p TIAM1 1.6344248374643 4.09278929749906e-13 -1.56411477781397 6.02866811798354e-13 MirTarget -0.175036441413721 0.000185184330625129 NA NA NA hsa-miR-1306-3p TIAM1 0.372101787981998 0.0348567520729812 -1.56411477781397 6.02866811798354e-13 MirTarget -0.144497638360102 0.0228166652005725 NA NA NA hsa-miR-146b-5p TIAM1 0.419719546795449 0.0457375823220155 -1.56411477781397 6.02866811798354e-13 miRanda -0.181625377721919 0.000441828409003034 NA NA NA hsa-miR-17-5p TIAM1 0.698861147045461 2.43854106455398e-05 -1.56411477781397 6.02866811798354e-13 MirTarget;TargetScan;miRNATAP -0.166143948023034 0.0110670498766355 NA NA NA hsa-miR-188-5p TIAM1 1.11646899351496 9.56686958408598e-11 -1.56411477781397 6.02866811798354e-13 MirTarget -0.31316394327389 3.26802391023596e-07 NA NA NA hsa-miR-20a-5p TIAM1 0.854326758727003 5.04256669663285e-07 -1.56411477781397 6.02866811798354e-13 MirTarget;miRNATAP -0.146807750673643 0.0206517910606264 NA NA NA hsa-miR-21-5p TIAM1 1.51084295924322 1.54551622173259e-34 -1.56411477781397 6.02866811798354e-13 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.321917397006639 7.35213503545411e-05 20826792 miR 21 and miR 31 converge on TIAM1 to regulate migration and invasion of colon carcinoma cells; We present compelling evidence that TIAM1 a guanidine exchange factor of the Rac GTPase is a direct target of both miR-21 and miR-31 colon cancer hsa-miR-221-3p TIAM1 1.12244756358612 3.48370308238012e-13 -1.56411477781397 6.02866811798354e-13 miRNAWalker2_validate -0.281862102724342 3.73338764540275e-05 NA NA NA hsa-miR-29a-5p TIAM1 -0.113555908626946 0.349622266470788 -1.56411477781397 6.02866811798354e-13 MirTarget -0.239309942044216 0.00816221484858509 NA NA NA hsa-miR-361-5p TIAM1 0.233202959858696 0.00961572812255327 -1.56411477781397 6.02866811798354e-13 miRanda -0.602195794234882 6.72364651452427e-07 NA NA NA hsa-miR-362-3p TIAM1 0.814007335895913 2.00108618836568e-09 -1.56411477781397 6.02866811798354e-13 miRanda -0.198484031189875 0.0121313814748348 NA NA NA hsa-miR-548b-3p TIAM1 -0.0203576084717134 0.930819503166956 -1.56411477781397 6.02866811798354e-13 miRNATAP -0.101446641451005 0.031795816980556 NA NA NA hsa-miR-589-3p TIAM1 1.16846704028095 5.88525574424201e-11 -1.56411477781397 6.02866811798354e-13 mirMAP -0.357714938740412 2.51981269041998e-09 NA NA NA hsa-miR-590-5p TIAM1 -0.103355559980404 0.310027295317092 -1.56411477781397 6.02866811798354e-13 MirTarget;PITA;miRanda;miRNATAP -0.516087373036729 1.49941649212639e-06 NA NA NA hsa-miR-653-5p TIAM1 0.249183073205674 0.297094995902194 -1.56411477781397 6.02866811798354e-13 MirTarget -0.112809574583845 0.0137378317350588 NA NA NA hsa-miR-93-3p TIAM1 0.402821129107592 0.00131324842735588 -1.56411477781397 6.02866811798354e-13 miRNAWalker2_validate -0.516252745636723 1.59336478577884e-09 NA NA NA hsa-miR-93-5p TIAM1 1.39518349670953 2.84167728726712e-25 -1.56411477781397 6.02866811798354e-13 MirTarget;miRNATAP -0.605002156316476 2.87605574583433e-16 NA NA NA hsa-miR-139-5p TIAM2 -2.11299531796557 8.16407076415038e-28 0.274060744872763 0.28969111744883 miRanda -0.199653502732438 0.00103144064488928 NA NA NA hsa-miR-139-5p TINAG -2.11299531796557 8.16407076415038e-28 2.88376286023904 1.31124068350619e-06 miRanda -1.07087635335819 8.21785239791543e-15 NA NA NA hsa-miR-10b-3p TLR10 2.77189254628215 2.26687582932628e-20 -0.88436671158121 0.0039806073782545 miRNATAP -0.107222998078413 0.0379550215188314 NA NA NA hsa-miR-139-5p TM4SF1 -2.11299531796557 8.16407076415038e-28 0.0238791400853353 0.907216330602844 mirMAP -0.161171593446258 0.000804520042423692 NA NA NA hsa-miR-139-5p TMC7 -2.11299531796557 8.16407076415038e-28 2.03760714579858 4.07529066351364e-21 miRanda -0.466942309614792 7.86042761588233e-20 NA NA NA hsa-miR-424-5p TMC7 -2.62653257498508 2.38997974737991e-50 2.03760714579858 4.07529066351364e-21 MirTarget -0.1773368202146 0.00139101886797736 NA NA NA hsa-miR-3607-3p TMCO3 -2.15518588554493 1.03390728226728e-23 1.05712590497992 6.76198433090657e-12 MirTarget -0.156894810350259 2.97910346870672e-06 NA NA NA hsa-miR-139-5p TMEFF1 -2.11299531796557 8.16407076415038e-28 1.22531596486822 7.35301173500991e-15 miRanda -0.213657719539241 1.62988915913846e-08 NA NA NA hsa-miR-3607-3p TMEFF1 -2.15518588554493 1.03390728226728e-23 1.22531596486822 7.35301173500991e-15 MirTarget;miRNATAP -0.196955736815116 1.02055240176927e-08 NA NA NA hsa-miR-139-5p TMEM107 -2.11299531796557 8.16407076415038e-28 0.289022420985638 0.0134603890139044 miRanda -0.11767404286605 1.72873268673182e-05 NA NA NA hsa-miR-3607-3p TMEM108 -2.15518588554493 1.03390728226728e-23 0.99389223387558 4.11528829750623e-05 MirTarget;miRNATAP -0.21443929948618 3.8492835990825e-05 NA NA NA hsa-miR-139-5p TMEM120B -2.11299531796557 8.16407076415038e-28 1.34193310296135 3.11902100235044e-43 mirMAP -0.255352801744528 1.51596228690801e-26 NA NA NA hsa-miR-33b-5p TMEM120B -2.28852395459234 2.69046626645242e-22 1.34193310296135 3.11902100235044e-43 mirMAP -0.112961766541873 8.30952065366857e-08 NA NA NA hsa-miR-424-5p TMEM120B -2.62653257498508 2.38997974737991e-50 1.34193310296135 3.11902100235044e-43 mirMAP -0.263371279547798 3.26795033868786e-26 NA NA NA hsa-miR-10b-3p TMEM154 2.77189254628215 2.26687582932628e-20 -2.55127196617094 2.61178039289766e-16 mirMAP -0.243432785851264 5.87707461952816e-06 NA NA NA hsa-miR-3607-3p TMEM164 -2.15518588554493 1.03390728226728e-23 1.2706908651988 7.63591092247221e-16 mirMAP -0.20448186393825 2.9486945323784e-09 NA NA NA hsa-miR-199a-3p TMEM170B -2.3279328685682 1.04468066198593e-17 -0.28665834823882 0.06540862544437 mirMAP -0.122249606258526 4.01456312098106e-06 NA NA NA hsa-miR-199b-3p TMEM170B -2.33226605401203 9.51887435273314e-18 -0.28665834823882 0.06540862544437 mirMAP -0.122164504815903 4.01248205147109e-06 NA NA NA hsa-miR-139-5p TMEM185B -2.11299531796557 8.16407076415038e-28 0.147227061630054 0.125967859161287 miRanda -0.129139446751067 6.43049289388549e-09 NA NA NA hsa-miR-139-5p TMEM198 -2.11299531796557 8.16407076415038e-28 1.11263779262795 9.21291761304099e-09 miRanda -0.174859736768242 0.0001576617615632 NA NA NA hsa-miR-424-5p TMEM198 -2.62653257498508 2.38997974737991e-50 1.11263779262795 9.21291761304099e-09 MirTarget -0.204034890858633 2.04697351466236e-05 NA NA NA hsa-miR-424-5p TMEM201 -2.62653257498508 2.38997974737991e-50 1.26425577239023 2.24180741272478e-27 mirMAP -0.201507557933122 1.26791035466797e-11 NA NA NA hsa-miR-224-5p TMEM47 2.67175249172213 1.46995328399796e-18 -1.6215856228956 1.26274970190329e-13 MirTarget -0.155353688438718 6.01168505448418e-06 NA NA NA hsa-miR-139-5p TMEM51 -2.11299531796557 8.16407076415038e-28 -0.140366804941824 0.496839345876924 miRanda -0.212189358587896 1.10429772199376e-05 NA NA NA hsa-miR-139-5p TMEM55A -2.11299531796557 8.16407076415038e-28 0.232337348356357 0.275861363532946 miRanda -0.263175032175052 1.11166963026416e-07 NA NA NA hsa-miR-183-5p TMEM56 2.33444328833177 1.52188109365421e-10 -1.75634225549522 4.44536598470124e-19 MirTarget -0.221808425248069 8.58402560812856e-18 NA NA NA hsa-miR-139-5p TMEM67 -2.11299531796557 8.16407076415038e-28 0.588504293532127 0.000540525442037226 miRanda -0.181997108608756 5.28125774548207e-06 NA NA NA hsa-miR-139-5p TMEM69 -2.11299531796557 8.16407076415038e-28 0.35034187533953 1.6258067224691e-05 MirTarget;miRanda -0.103964995837809 4.3474929847859e-08 NA NA NA hsa-miR-139-3p TMEM8B -2.53151940925585 1.56777509736867e-36 0.61369846980962 7.22239585086116e-09 miRNATAP -0.110290528163302 3.35122676885411e-06 NA NA NA hsa-miR-139-5p TMEM98 -2.11299531796557 8.16407076415038e-28 0.740903970105259 0.00794498819388702 miRanda -0.167279988206658 0.0112747183033154 NA NA NA hsa-miR-183-5p TMSB4Y 2.33444328833177 1.52188109365421e-10 -0.00486122903179842 0.991413362265245 miRNATAP -0.205645451047042 0.000457791030873375 NA NA NA hsa-miR-424-5p TOM1L2 -2.62653257498508 2.38997974737991e-50 0.409072452599841 6.18452585812519e-05 mirMAP -0.116730371421868 2.71420017609535e-06 NA NA NA hsa-miR-139-5p TOP2A -2.11299531796557 8.16407076415038e-28 4.1548998577835 1.29817805633082e-49 miRanda -0.962231267816668 3.62861978228759e-47 26079880 We identified that miR-139 a previous reported anti-metastatic microRNA targets 3'-untranslated region 3'UTR of TOP2a mRNA; Further more we revealed that the forced expression of miR-139 reduces the TOP2a expression at both mRNA and protein levels; And our functional experiments showed that the ectopic expression of miR-139 remarkably inhibits proliferation in luminal type breast cancer cells while exogenous TOP2a expression could rescue inhibition of cell proliferation mediated by miR-139 breast cancer hsa-miR-139-5p TOPBP1 -2.11299531796557 8.16407076415038e-28 0.742506324879209 2.82032014342639e-13 miRanda -0.173144753015241 5.1848832793239e-13 NA NA NA hsa-miR-139-5p TPD52 -2.11299531796557 8.16407076415038e-28 0.203850972949828 0.121221328808663 MirTarget;miRanda;miRNATAP -0.147596607340814 1.4842367536555e-06 NA NA NA hsa-miR-139-5p TPM3 -2.11299531796557 8.16407076415038e-28 0.578207057334502 5.14265638402526e-17 PITA -0.171410961207701 1.34947238244838e-27 NA NA NA hsa-miR-183-5p TPRG1L 2.33444328833177 1.52188109365421e-10 -0.758883371513601 2.47046358234149e-10 miRNAWalker2_validate -0.123006349506335 1.63582237119294e-15 NA NA NA hsa-miR-139-5p TRAFD1 -2.11299531796557 8.16407076415038e-28 0.226216444993726 0.00443005679697159 miRanda -0.136836859052956 4.87076336491642e-14 NA NA NA hsa-miR-139-5p TRAIP -2.11299531796557 8.16407076415038e-28 3.28644450772872 2.26380689657191e-46 miRanda -0.757420420372108 1.25650774265256e-43 NA NA NA hsa-miR-224-5p TRIB1 2.67175249172213 1.46995328399796e-18 -2.10293508198024 5.6684896439399e-40 MirTarget -0.138693744413184 1.79705642358923e-07 24382668 MicroRNA 224 inhibits progression of human prostate cancer by downregulating TRIB1; In this study we identified TRIB1 as a target gene of miR-224; Forced expression of miR-224 suppressed PCa cell proliferation invasion and migration and promoted cell apoptosis by downregulating TRIB1; Moreover the expression level of miR-224 in PCa tissues was negatively correlated with that of TRIB1 miR-224 downregulation was frequently found in PCa tissues with metastasis higher PSA level and clinical stage whereas TRIB1 upregulation was significantly associated with metastasis; Both miR-224 downregulation and TRIB1 upregulation were significantly associated with poor biochemical recurrence-free survival of patients with PCa; In conclusion these findings reveal that the aberrant expression of miR-224 and TRIB1 may promote PCa progression and have potentials to serve as novel biomarkers for PCa prognosis progression;staging;metastasis;poor survival;recurrence;worse prognosis prostate cancer hsa-miR-183-5p TRIM2 2.33444328833177 1.52188109365421e-10 -0.669569001903942 0.000204730952595103 miRNATAP -0.111711799538665 1.90307702413872e-06 NA NA NA hsa-miR-224-5p TRIM35 2.67175249172213 1.46995328399796e-18 -0.908312943568019 1.50923347465387e-09 mirMAP -0.10224683252153 1.16185060889052e-05 NA NA NA hsa-miR-139-5p TRIM37 -2.11299531796557 8.16407076415038e-28 0.505705876409016 2.91553461671614e-08 miRanda -0.126703356129918 3.29329700357991e-09 NA NA NA hsa-miR-424-5p TRIM59 -2.62653257498508 2.38997974737991e-50 1.7356935499647 4.96522875209022e-19 MirTarget -0.182755030810837 0.000230497137028395 NA NA NA hsa-miR-139-5p TRIM6 -2.11299531796557 8.16407076415038e-28 0.684176208198113 0.00802500623776597 miRanda -0.361611210016454 1.62232393052915e-09 NA NA NA hsa-miR-139-5p TRIM71 -2.11299531796557 8.16407076415038e-28 1.88705329759216 3.31797883877253e-06 miRanda -0.571817655983757 1.84904554007401e-09 NA NA NA hsa-miR-3607-3p TRIM71 -2.15518588554493 1.03390728226728e-23 1.88705329759216 3.31797883877253e-06 MirTarget -0.333657911403206 0.000140588887825005 NA NA NA hsa-miR-3607-3p TRNP1 -2.15518588554493 1.03390728226728e-23 0.515091171409026 0.129708747774963 mirMAP -0.241506768744323 0.00089660427838963 NA NA NA hsa-miR-183-5p TRO 2.33444328833177 1.52188109365421e-10 -0.982188770336062 5.74259015713826e-05 miRNAWalker2_validate -0.14665774607549 4.10309602581488e-06 NA NA NA hsa-miR-139-5p TRPC1 -2.11299531796557 8.16407076415038e-28 0.308490971924318 0.14555420535354 miRanda -0.263173182030172 9.44912185589915e-08 NA NA NA hsa-miR-33b-5p TRPC6 -2.28852395459234 2.69046626645242e-22 2.22073873779916 1.0596496372505e-29 MirTarget -0.257883898317174 2.75322874228911e-10 NA NA NA hsa-miR-139-5p TSC1 -2.11299531796557 8.16407076415038e-28 0.920881916944059 1.33648384372723e-19 mirMAP -0.138969507847749 1.79604322012115e-08 NA NA NA hsa-miR-139-5p TSPAN3 -2.11299531796557 8.16407076415038e-28 0.0573084342867682 0.616032989656141 MirTarget;PITA;miRanda;miRNATAP -0.130558210922172 8.94006161936077e-07 NA NA NA hsa-miR-10b-3p TSPYL5 2.77189254628215 2.26687582932628e-20 -1.77057901747748 4.6912848761307e-17 mirMAP -0.232595427964056 1.01676794948731e-10 NA NA NA hsa-miR-139-5p TTC21A -2.11299531796557 8.16407076415038e-28 0.220475382996912 0.114232630333462 miRanda -0.118785623959815 0.00028592431465575 NA NA NA hsa-miR-139-5p TTC39A -2.11299531796557 8.16407076415038e-28 2.64467452765163 1.3333642353103e-14 miRanda -0.79183643183616 1.74175246371357e-23 NA NA NA hsa-miR-139-5p TTK -2.11299531796557 8.16407076415038e-28 4.46695225538541 3.90954998066403e-48 miRanda -1.02753150497536 5.11914670343957e-45 NA NA NA hsa-miR-139-5p TTL -2.11299531796557 8.16407076415038e-28 0.841369670415339 1.94156847812526e-22 miRanda -0.121266737705701 8.68061926994732e-09 NA NA NA hsa-miR-424-5p TTL -2.62653257498508 2.38997974737991e-50 0.841369670415339 1.94156847812526e-22 MirTarget -0.181798052404328 1.74142679338002e-17 NA NA NA hsa-miR-3607-3p TTYH3 -2.15518588554493 1.03390728226728e-23 0.770555614902691 1.06180020960171e-06 mirMAP;miRNATAP -0.169073545214061 6.08885547819543e-07 NA NA NA hsa-miR-139-5p TULP3 -2.11299531796557 8.16407076415038e-28 0.66268005203974 8.07525998062289e-12 miRanda -0.182412624509381 6.72939911588976e-16 NA NA NA hsa-miR-139-5p TXNRD1 -2.11299531796557 8.16407076415038e-28 0.929311509729049 2.14760881993393e-07 miRanda -0.219017059178943 2.30022104830631e-07 NA NA NA hsa-miR-183-5p TXNRD2 2.33444328833177 1.52188109365421e-10 -0.474975061463629 0.000513666428267915 mirMAP -0.108896134921397 5.93844866720077e-10 NA NA NA hsa-miR-424-5p TYSND1 -2.62653257498508 2.38997974737991e-50 0.507266973985128 1.57055994947472e-05 mirMAP -0.201882771059346 8.07451605349208e-13 NA NA NA hsa-miR-139-5p UBAP2 -2.11299531796557 8.16407076415038e-28 0.596503483369584 2.1695853714839e-11 miRanda -0.176008824146188 1.48776701078131e-17 NA NA NA hsa-miR-139-5p UBAP2L -2.11299531796557 8.16407076415038e-28 0.971939144855086 1.81359192544576e-28 miRanda -0.208006118575858 3.34512059255679e-23 NA NA NA hsa-miR-139-5p UBE2D1 -2.11299531796557 8.16407076415038e-28 0.0779402641757883 0.369347660871645 MirTarget;PITA;miRanda -0.101082994405299 5.18239582350099e-07 NA NA NA hsa-miR-139-5p UBE2E1 -2.11299531796557 8.16407076415038e-28 0.25760238174291 9.67568894003239e-05 miRanda -0.104515635119264 6.23620396098919e-12 NA NA NA hsa-miR-424-5p UBE2Q1 -2.62653257498508 2.38997974737991e-50 0.732919157465649 1.09455000536515e-20 MirTarget;miRNATAP -0.198517354627529 9.30655618641617e-26 NA NA NA hsa-miR-139-5p UBE2Q2 -2.11299531796557 8.16407076415038e-28 0.681211675549137 2.94083418901206e-05 miRanda -0.260606835307766 5.63406157357292e-12 NA NA NA hsa-miR-3607-3p UBE2Q2 -2.15518588554493 1.03390728226728e-23 0.681211675549137 2.94083418901206e-05 mirMAP -0.106458967793747 0.00248908581679628 NA NA NA hsa-miR-139-5p UBE2Z -2.11299531796557 8.16407076415038e-28 0.338436185365393 1.5249081267636e-06 miRanda -0.169982041067609 1.55131516470563e-27 NA NA NA hsa-miR-139-5p UBR5 -2.11299531796557 8.16407076415038e-28 0.630017235825055 3.7913049521189e-11 miRanda -0.127413599058659 1.73500373291866e-08 NA NA NA hsa-miR-139-5p UCK2 -2.11299531796557 8.16407076415038e-28 1.18360816028226 8.55973566464538e-22 miRanda -0.349697661197361 1.3516386817231e-35 NA NA NA hsa-miR-144-3p UCK2 -2.97536914478815 6.00546047309683e-28 1.18360816028226 8.55973566464538e-22 MirTarget -0.136246806830939 1.63289574616974e-10 NA NA NA hsa-miR-199a-3p UCK2 -2.3279328685682 1.04468066198593e-17 1.18360816028226 8.55973566464538e-22 MirTarget;PITA;miRNATAP -0.178196380644244 1.24303852450857e-16 NA NA NA hsa-miR-199b-3p UCK2 -2.33226605401203 9.51887435273314e-18 1.18360816028226 8.55973566464538e-22 MirTarget;PITA -0.178126845121161 1.21251922387563e-16 NA NA NA hsa-miR-3607-3p UCP3 -2.15518588554493 1.03390728226728e-23 0.738404617511284 2.64780777542046e-07 MirTarget;miRNATAP -0.15221590675576 8.00637532554003e-07 NA NA NA hsa-miR-139-5p UFD1L -2.11299531796557 8.16407076415038e-28 0.646593921117335 9.10795189171824e-14 miRanda -0.109746741871627 1.23951019228872e-07 NA NA NA hsa-miR-139-5p UHRF1 -2.11299531796557 8.16407076415038e-28 3.49841769196073 9.81871544089538e-40 miRanda -0.865484888147862 2.21138740927036e-44 NA NA NA hsa-miR-3607-3p UHRF1BP1 -2.15518588554493 1.03390728226728e-23 0.5401627924825 2.70756975187287e-07 mirMAP -0.106299990506076 2.4920135331865e-06 NA NA NA hsa-miR-10b-3p ULK2 2.77189254628215 2.26687582932628e-20 -0.751057335334513 0.00080135979131828 MirTarget -0.148313505499471 7.61598951514493e-05 NA NA NA hsa-miR-3607-3p UNC119B -2.15518588554493 1.03390728226728e-23 1.21392832041535 7.88210718787103e-18 MirTarget -0.22063365617687 6.61569391869976e-13 NA NA NA hsa-miR-424-5p UNC119B -2.62653257498508 2.38997974737991e-50 1.21392832041535 7.88210718787103e-18 MirTarget -0.249615206981485 1.04823904186065e-12 NA NA NA hsa-miR-139-5p UNC45A -2.11299531796557 8.16407076415038e-28 0.52040608832935 2.25934223959886e-11 MirTarget;miRanda -0.111495305228372 1.30821959937836e-09 NA NA NA hsa-miR-675-3p UNC5A -2.78074157259259 1.41541888062227e-14 1.46086450181082 6.53455896088854e-07 mirMAP -0.140985024548893 0.000261107536176746 NA NA NA hsa-miR-424-5p URM1 -2.62653257498508 2.38997974737991e-50 0.377286722665545 4.08493862379565e-05 mirMAP -0.129237030427435 6.2345095225616e-09 NA NA NA hsa-miR-224-5p USH2A 2.67175249172213 1.46995328399796e-18 -2.26734306551942 1.94801387719099e-11 MirTarget -0.106054530096913 0.0463753062502311 NA NA NA hsa-miR-424-5p USP22 -2.62653257498508 2.38997974737991e-50 0.620225817612547 2.78559526456339e-10 mirMAP -0.155125064845832 1.02100021588635e-10 NA NA NA hsa-miR-424-5p USP31 -2.62653257498508 2.38997974737991e-50 0.3853853894618 0.000159436643509761 MirTarget -0.103202067486527 3.43520028553978e-05 NA NA NA hsa-miR-424-5p VAMP1 -2.62653257498508 2.38997974737991e-50 0.935705568113554 2.5969593106832e-11 miRNATAP -0.156851423374941 6.8387156233162e-06 NA NA NA hsa-miR-144-3p VCAN -2.97536914478815 6.00546047309683e-28 0.3467634039065 0.320202578720279 miRNATAP -0.171784534241824 0.00323687285143018 NA NA NA hsa-miR-33b-5p VCAN -2.28852395459234 2.69046626645242e-22 0.3467634039065 0.320202578720279 MirTarget -0.137472856543622 0.0461873920480764 NA NA NA hsa-miR-150-5p VEGFA -1.14624309254329 1.51365525978726e-06 0.0263183839451075 0.81382635000524 miRNAWalker2_validate;miRTarBase -0.114666527453602 2.4663414134099e-07 NA NA NA hsa-miR-29b-2-5p VEGFA -0.223258653034772 0.084306146519938 0.0263183839451075 0.81382635000524 MirTarget -0.132006150652748 0.00171675395806506 NA NA NA hsa-miR-29b-3p VEGFA -0.348885528720517 0.0121441341291285 0.0263183839451075 0.81382635000524 miRNAWalker2_validate;miRTarBase;MirTarget -0.125790856471025 0.00126089778683366 26155940;22815235 Moreover miR-29b inhibits angiogenesis by attenuating tube formation and the expression of VEGF and Ang-2 and stemness maintenance in GBM cells as demonstrated by decreasing neurosphere formation and cancer stem cell marker protein expression;Additionally for two genes that are deregulated in PCa heterogeneous nuclear ribonucleoprotein K hnRNP-K and vascular endothelial growth factor A VEGF-A we identified two regulatory miRNAs miR-205 and miR-29b ; glioblastoma;prostate cancer hsa-miR-140-5p VEGFB -0.220106443070144 0.0140713197101242 0.0320278813662975 0.892480348417874 miRanda -0.268562632744809 0.0395419509098586 NA NA NA hsa-miR-128-3p VEGFC 0.289735108018712 0.0114419474207889 0.0031169028254141 0.982787493023474 miRNAWalker2_validate;MirTarget -0.198618366596319 0.00124097531466772 25001183;26722309 Interestingly ectopic miR-128 overexpression could significantly inhibit vascular endothelial growth factor VEGF-C expression and reduce the activity of a luciferase reporter containing the VEGF-C 3'-untranslated region; These findings suggest that miR-128 could play a role in NSCLC tumourigenesis at least in part by modulation of angiogenesis and lymphangiogenesis through targeting VEGF-C and could simultaneously block ERK AKT and p38 signalling pathways;miR 128 downregulation promotes growth and metastasis of bladder cancer cells and involves VEGF C upregulation; To investigate the regulation of miR-128 on VEGF-C expression and their effects on proliferation and metastasis of bladder cancer T24 and 5637 BC cells were transfected with pre-miR-128 anti-miR-128 and their respective negative control; miR-128 was downregulated in BC tissues and cell lines while the expression levels of VEGF-C were upregulated; The present results indicated that miR-128 negatively regulated VEGF-C expression in BC T24 and 5637 BC cells; VEGF-C is a direct target of miR-128 in BC cells ;metastasis lung squamous cell cancer;bladder cancer hsa-miR-16-2-3p VEGFC -0.0336420826463706 0.805158952566973 0.0031169028254141 0.982787493023474 MirTarget -0.149514000508957 0.00387572506927192 NA NA NA hsa-miR-374a-5p VEGFC 0.016390363747302 0.869784217438621 0.0031169028254141 0.982787493023474 MirTarget -0.28522635078723 5.53265846690998e-05 NA NA NA hsa-miR-374b-5p VEGFC -0.307538028546424 0.0030079617545972 0.0031169028254141 0.982787493023474 MirTarget -0.209454919974677 0.00209421071373184 NA NA NA hsa-miR-590-3p VEGFC -0.473167498047808 1.76652934637227e-05 0.0031169028254141 0.982787493023474 miRanda -0.274821384359749 1.36978001441178e-05 NA NA NA hsa-miR-424-5p VPS33B -2.62653257498508 2.38997974737991e-50 0.38788528263127 6.34766290694475e-10 MirTarget -0.114278948338282 3.56220062960745e-14 NA NA NA hsa-miR-139-5p VPS54 -2.11299531796557 8.16407076415038e-28 0.349280913555388 5.72682991930042e-05 miRanda -0.102120086839293 5.02037371379298e-07 NA NA NA hsa-miR-424-5p VWF -2.62653257498508 2.38997974737991e-50 1.44034219749898 1.02989206792567e-11 mirMAP -0.240836784366552 4.8746962377372e-06 NA NA NA hsa-miR-3607-3p WASF1 -2.15518588554493 1.03390728226728e-23 0.439540363305626 0.00258561023132441 MirTarget -0.137705427637225 9.69591988434732e-06 NA NA NA hsa-miR-139-5p WDR6 -2.11299531796557 8.16407076415038e-28 0.0762260983295056 0.402974921325117 miRanda -0.102391126518187 1.32374531665912e-06 NA NA NA hsa-miR-3607-3p WFS1 -2.15518588554493 1.03390728226728e-23 0.90593638071211 1.15573765581105e-15 miRNATAP -0.111235991710041 7.93461384146616e-06 NA NA NA hsa-miR-139-5p WIF1 -2.11299531796557 8.16407076415038e-28 0.556794941584025 0.11285363711586 miRanda -0.173226865020953 0.0367605397245844 NA NA NA hsa-miR-424-5p WIPI2 -2.62653257498508 2.38997974737991e-50 0.170521508783927 0.0184021828910785 MirTarget;miRNATAP -0.103305403980588 2.40535988398053e-09 NA NA NA hsa-miR-10b-5p WNK2 2.86931593037303 6.97409423207806e-23 -1.89518323977929 0.000316140316980393 mirMAP -0.22436245780157 0.00739383418864702 NA NA NA hsa-miR-1269a WNK2 3.57543539205634 4.25369619949175e-08 -1.89518323977929 0.000316140316980393 mirMAP -0.231603314452218 8.5735072322763e-09 NA NA NA hsa-miR-424-5p WNT3A -2.62653257498508 2.38997974737991e-50 1.98708616870099 1.63071643507271e-06 MirTarget;miRNATAP -0.276402093402075 0.00707893809064417 NA NA NA hsa-miR-10b-5p WNT7B 2.86931593037303 6.97409423207806e-23 -2.49986156980565 3.55477150766295e-09 mirMAP -0.274981207829556 5.13137898629338e-05 NA NA NA hsa-miR-33b-5p WSCD1 -2.28852395459234 2.69046626645242e-22 0.722138981010608 0.00285667688709021 mirMAP -0.106335882006387 0.0268637583762349 NA NA NA hsa-miR-33b-5p WTIP -2.28852395459234 2.69046626645242e-22 -0.0832426426141142 0.690200115614904 mirMAP -0.121400183554476 0.00315510751876842 NA NA NA hsa-miR-10b-3p XYLT1 2.77189254628215 2.26687582932628e-20 -0.33071246838403 0.0992663538586554 mirMAP -0.129674056511741 0.000103706258928047 NA NA NA hsa-miR-139-5p YWHAQ -2.11299531796557 8.16407076415038e-28 0.105106147496931 0.185320360738181 MirTarget;PITA;miRanda;miRNATAP -0.134903753655919 8.26465948813414e-14 NA NA NA hsa-miR-451a YWHAZ -2.1025161666445 6.82555767537341e-17 0.521348507448096 2.46588555709085e-06 MirTarget;miRNATAP -0.125160799099819 8.46499537092129e-10 26885274 miR 451 regulates FoxO3 nuclear accumulation through Ywhaz in human colorectal cancer; In this study expressions of miR-451 and Ywhaz in CRC tissues and adjacent normal tissues were detected by quantitative real-time PCR qRT-PCR and immunohistochemistry respectively; Ywhaz-3'UTR luciferase reporter assay confirmed Ywhaz as a direct target gene of miR-451; miR-451 may inhibit the colon cancer growth in vitro and in vivo likely through directly targeting Ywhaz and indirectly regulating the nuclear accumulation of FoxO3 colorectal cancer hsa-miR-139-5p ZBED4 -2.11299531796557 8.16407076415038e-28 0.53235542847144 2.61984249684361e-08 miRanda -0.144435091956163 1.11898897290443e-10 NA NA NA hsa-miR-139-5p ZBTB34 -2.11299531796557 8.16407076415038e-28 0.377013703257521 0.000168925671855812 MirTarget;PITA;miRanda;miRNATAP -0.10212785744934 1.45150804706166e-05 NA NA NA hsa-miR-3607-3p ZBTB46 -2.15518588554493 1.03390728226728e-23 0.368572640104064 0.00472649256163026 mirMAP -0.124603789053842 7.39150621935004e-06 NA NA NA hsa-miR-424-5p ZBTB9 -2.62653257498508 2.38997974737991e-50 0.87712713759988 1.92214381535763e-22 MirTarget;miRNATAP -0.200577250887266 1.3790832041738e-19 NA NA NA hsa-miR-139-5p ZFAT -2.11299531796557 8.16407076415038e-28 0.719586558209774 5.29660127315206e-16 miRanda -0.136129740229131 1.37089757523092e-10 NA NA NA hsa-miR-424-5p ZFP41 -2.62653257498508 2.38997974737991e-50 1.68571425193753 7.24184178265088e-33 mirMAP -0.3598149919066 2.46993308002298e-24 NA NA NA hsa-miR-144-3p ZIC5 -2.97536914478815 6.00546047309683e-28 4.44809220034826 7.64790908674987e-20 MirTarget -0.585235181085354 2.57122294516149e-12 NA NA NA hsa-miR-139-5p ZNF107 -2.11299531796557 8.16407076415038e-28 0.771236341592099 1.95705364731885e-05 MirTarget;miRanda -0.229738105703989 5.97949728955036e-08 NA NA NA hsa-miR-139-5p ZNF143 -2.11299531796557 8.16407076415038e-28 0.469322290310214 1.29116239182497e-11 miRanda -0.115616815846913 1.04070279967325e-12 NA NA NA hsa-miR-139-5p ZNF207 -2.11299531796557 8.16407076415038e-28 0.476017454845254 1.69423309001909e-17 miRanda -0.132547788994787 4.62206644447729e-25 NA NA NA hsa-miR-33b-5p ZNF208 -2.28852395459234 2.69046626645242e-22 0.872770984622935 0.00951289451277261 mirMAP -0.269485411138013 4.75740188296013e-05 NA NA NA hsa-miR-139-5p ZNF226 -2.11299531796557 8.16407076415038e-28 0.398458396409257 0.000116569338540428 miRanda -0.100032756437452 3.97182574771644e-05 NA NA NA hsa-miR-139-5p ZNF234 -2.11299531796557 8.16407076415038e-28 0.50804795279551 6.02620948892739e-07 miRanda -0.119586610798777 6.22991716397605e-07 NA NA NA hsa-miR-139-5p ZNF260 -2.11299531796557 8.16407076415038e-28 0.365977608946996 1.97987366144518e-05 miRanda -0.101226427981946 4.73702751307217e-07 NA NA NA hsa-miR-139-5p ZNF273 -2.11299531796557 8.16407076415038e-28 0.827625040045322 1.67244417517975e-08 miRanda -0.229871768959412 2.24918672643209e-11 NA NA NA hsa-miR-139-5p ZNF337 -2.11299531796557 8.16407076415038e-28 0.766899676902488 1.25736573851398e-17 miRanda -0.169604506127738 1.40885703811404e-15 NA NA NA hsa-miR-424-5p ZNF346 -2.62653257498508 2.38997974737991e-50 0.50201482926775 2.29175498618488e-11 MirTarget -0.109702681109025 2.51640935314649e-09 NA NA NA hsa-miR-3607-3p ZNF382 -2.15518588554493 1.03390728226728e-23 0.729965631053667 0.00131376945798913 miRNATAP -0.123034033347366 0.0119594724708751 NA NA NA hsa-miR-139-5p ZNF431 -2.11299531796557 8.16407076415038e-28 0.804712572242941 1.61521871253386e-05 miRanda -0.219968298658795 5.48487872890586e-07 NA NA NA hsa-miR-424-5p ZNF445 -2.62653257498508 2.38997974737991e-50 0.324928283703971 0.00026271162993416 mirMAP -0.100539795624811 3.37785415588487e-06 NA NA NA hsa-miR-424-5p ZNF449 -2.62653257498508 2.38997974737991e-50 0.731857019114456 1.65613647215576e-14 MirTarget;miRNATAP -0.119012909154228 5.56907245696145e-07 NA NA NA hsa-miR-33b-5p ZNF471 -2.28852395459234 2.69046626645242e-22 -1.02445139017411 0.000664294071232151 mirMAP -0.14559771629988 0.0148873806704782 NA NA NA hsa-miR-139-5p ZNF473 -2.11299531796557 8.16407076415038e-28 0.673373838200895 2.70940472767388e-16 miRanda -0.146013986880532 6.53406579558286e-14 NA NA NA hsa-miR-424-5p ZNF512B -2.62653257498508 2.38997974737991e-50 0.949756749303405 1.79541489585724e-18 mirMAP -0.264124267523955 4.60945423228808e-24 NA NA NA hsa-miR-33b-5p ZNF525 -2.28852395459234 2.69046626645242e-22 0.380533080060995 0.13415403710575 mirMAP -0.225471703766213 5.82652112380884e-06 NA NA NA hsa-miR-139-5p ZNF532 -2.11299531796557 8.16407076415038e-28 0.726511739143307 7.11049790812266e-06 MirTarget;PITA;miRanda;miRNATAP -0.168207314078646 1.0838953151887e-05 NA NA NA hsa-miR-3607-3p ZNF532 -2.15518588554493 1.03390728226728e-23 0.726511739143307 7.11049790812266e-06 mirMAP -0.180026537386913 1.97685082395315e-07 NA NA NA hsa-miR-139-5p ZNF550 -2.11299531796557 8.16407076415038e-28 0.658482767117193 9.06419487762518e-05 miRanda -0.1257898403007 0.001602052155092 NA NA NA hsa-miR-139-5p ZNF572 -2.11299531796557 8.16407076415038e-28 1.32697063620741 6.58899950061161e-15 miRanda -0.238296005619486 5.48390025647388e-09 NA NA NA hsa-miR-139-5p ZNF589 -2.11299531796557 8.16407076415038e-28 0.820382542806512 1.70494909704044e-14 miRanda -0.222455932898531 4.20808694548039e-19 NA NA NA hsa-miR-144-3p ZNF607 -2.97536914478815 6.00546047309683e-28 1.1523089399405 6.34759561976684e-08 MirTarget -0.165128959296442 4.36315174830124e-06 NA NA NA hsa-miR-144-3p ZNF618 -2.97536914478815 6.00546047309683e-28 0.943831859691578 2.40047580237559e-12 miRNATAP -0.157738545387055 2.8992271835554e-12 NA NA NA hsa-miR-3607-3p ZNF618 -2.15518588554493 1.03390728226728e-23 0.943831859691578 2.40047580237559e-12 mirMAP;miRNATAP -0.191513971957871 4.00311630608637e-11 NA NA NA hsa-miR-424-5p ZNF691 -2.62653257498508 2.38997974737991e-50 0.392903854612492 2.3730524740257e-05 MirTarget -0.159247242020168 8.6432341702276e-13 NA NA NA hsa-miR-3607-3p ZNF695 -2.15518588554493 1.03390728226728e-23 2.00105681453715 7.13904622370828e-08 MirTarget -0.250790302944152 0.00190906458472589 NA NA NA hsa-miR-139-5p ZNF71 -2.11299531796557 8.16407076415038e-28 0.975763663105881 1.64193178677823e-10 miRanda -0.242473174296553 1.53515329312773e-11 NA NA NA hsa-miR-3607-3p ZNF711 -2.15518588554493 1.03390728226728e-23 -0.0288932356090779 0.926637499360174 MirTarget;miRNATAP -0.224034900785885 0.000830191586120485 NA NA NA hsa-miR-139-5p ZNF714 -2.11299531796557 8.16407076415038e-28 0.754364838089509 0.00473113650368115 miRanda -0.31387774922993 5.07986608668751e-07 NA NA NA hsa-miR-139-5p ZNF718 -2.11299531796557 8.16407076415038e-28 1.43235034293907 8.38342276280854e-10 miRanda -0.271864147499383 2.20451983727295e-11 NA NA NA hsa-miR-424-5p ZNF746 -2.62653257498508 2.38997974737991e-50 0.504549701393687 1.81855502334155e-07 mirMAP -0.120187674053111 3.77074797388291e-07 NA NA NA hsa-miR-139-5p ZNF792 -2.11299531796557 8.16407076415038e-28 0.88178827950768 7.59290448450019e-16 MirTarget;miRanda -0.253574447578332 1.05161323724769e-23 NA NA NA hsa-miR-139-5p ZNF93 -2.11299531796557 8.16407076415038e-28 0.526360727271378 0.0371742056628529 miRanda -0.275110624179788 3.23307941105881e-06 NA NA NA hsa-miR-139-5p ZNHIT3 -2.11299531796557 8.16407076415038e-28 0.441171934597975 3.91458513190926e-09 miRanda -0.112114556514666 1.65061805042791e-10 NA NA NA hsa-miR-139-5p ZSCAN20 -2.11299531796557 8.16407076415038e-28 0.738097107597709 1.74179696867163e-07 miRanda -0.252897087649294 1.07664626551108e-14 NA NA NA hsa-miR-424-5p ZSWIM3 -2.62653257498508 2.38997974737991e-50 0.350845864215868 3.63386686673281e-06 MirTarget;miRNATAP -0.13143612969413 4.22036840414944e-13 NA NA NA