miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-128-3p ABL1 0.98280381420517 5.77641850797209e-05 -0.962651345833518 7.23950193567278e-09 MirTarget -0.163562699793361 0.00096410618700775 NA NA NA hsa-miR-141-3p ABL1 1.45548825076434 0.00115958850961764 -0.962651345833518 7.23950193567278e-09 MirTarget -0.186139786843855 2.57511874966351e-13 NA NA NA hsa-miR-142-5p ABL1 1.55592486377018 6.69269968016779e-06 -0.962651345833518 7.23950193567278e-09 MirTarget -0.17367110583317 2.89817954365468e-07 NA NA NA hsa-miR-15b-3p ABL1 1.75738933306437 3.00554466232543e-08 -0.962651345833518 7.23950193567278e-09 MirTarget -0.15157398070684 4.00456618892552e-05 NA NA NA hsa-miR-15b-5p ABL1 1.62046407540723 5.42152621571078e-09 -0.962651345833518 7.23950193567278e-09 mirMAP -0.196565551881613 2.59795461494049e-06 NA NA NA hsa-miR-16-5p ABL1 1.00515772948091 5.33912942007619e-06 -0.962651345833518 7.23950193567278e-09 mirMAP -0.283118977596646 1.253060404789e-07 NA NA NA hsa-miR-19a-3p ABL1 1.26669687448473 0.000105972838514412 -0.962651345833518 7.23950193567278e-09 mirMAP -0.156990735722488 1.6421639310259e-05 NA NA NA hsa-miR-200a-3p ABL1 0.717826667295984 0.193912116506827 -0.962651345833518 7.23950193567278e-09 MirTarget -0.123971838305621 6.33875256738154e-09 NA NA NA hsa-miR-29a-5p ABL1 0.585084040404152 0.023014129158495 -0.962651345833518 7.23950193567278e-09 MirTarget -0.126437521845138 0.00826584797822056 NA NA NA hsa-miR-30b-5p ABL1 -0.430720743745757 0.0593564057320791 -0.962651345833518 7.23950193567278e-09 MirTarget;miRNATAP -0.143381643266005 0.00830489235379627 NA NA NA hsa-miR-30e-5p ABL1 -0.573784818166736 0.0112497802572927 -0.962651345833518 7.23950193567278e-09 MirTarget;miRNATAP -0.145019804823193 0.00794227636205602 NA NA NA hsa-miR-330-5p ABL1 0.488365986827708 0.0512207630808233 -0.962651345833518 7.23950193567278e-09 MirTarget -0.242931653509721 4.59623710204268e-07 NA NA NA hsa-miR-423-5p ABL1 0.832613878736338 0.000791321227103338 -0.962651345833518 7.23950193567278e-09 MirTarget -0.149057687668797 0.00244756506789077 NA NA NA hsa-miR-484 ABL1 0.71327898984355 0.00233605130771196 -0.962651345833518 7.23950193567278e-09 miRNAWalker2_validate -0.260870463943224 3.55629586858196e-07 NA NA NA hsa-miR-503-5p ABL1 1.88558728489534 2.26317868368257e-06 -0.962651345833518 7.23950193567278e-09 mirMAP -0.103276345406703 0.000511388601881552 NA NA NA hsa-let-7d-5p ABL2 0.981733854788227 7.26366577706469e-07 0.256972282818825 0.189220286867016 miRNATAP -0.217774144074276 0.00165930999241277 NA NA NA hsa-let-7g-3p ABL2 0.64979533805273 0.0103084600883006 0.256972282818825 0.189220286867016 mirMAP -0.191604998945247 0.000454094160799048 NA NA NA hsa-let-7g-5p ABL2 0.325297685027927 0.241142963826631 0.256972282818825 0.189220286867016 miRNATAP -0.152257760189415 0.00244955141031791 NA NA NA hsa-miR-106b-5p ABL2 1.70863907461894 2.04074794107142e-08 0.256972282818825 0.189220286867016 MirTarget -0.176780297939492 4.87728659128018e-05 NA NA NA hsa-miR-107 ABL2 0.904627575346218 4.67936495073904e-05 0.256972282818825 0.189220286867016 MirTarget;PITA;miRanda;miRNATAP -0.282798568997241 3.69066158565993e-06 NA NA NA hsa-miR-126-5p ABL2 0.41765430251855 0.0753161203651532 0.256972282818825 0.189220286867016 mirMAP -0.18495105398709 0.00191173826709724 NA NA NA hsa-miR-1266-5p ABL2 0.214881660714884 0.741561405223711 0.256972282818825 0.189220286867016 MirTarget -0.11928514261981 1.01765542818604e-08 NA NA NA hsa-miR-128-3p ABL2 0.98280381420517 5.77641850797209e-05 0.256972282818825 0.189220286867016 MirTarget -0.190367493274152 0.000685714223132655 NA NA NA hsa-miR-140-3p ABL2 -0.296251775392129 0.127539826012144 0.256972282818825 0.189220286867016 miRNAWalker2_validate -0.235713288356787 0.00119009191880487 NA NA NA hsa-miR-148a-5p ABL2 -0.69329616490858 0.0793012233740369 0.256972282818825 0.189220286867016 miRNATAP -0.19127677107539 1.77403172171384e-08 NA NA NA hsa-miR-15b-5p ABL2 1.62046407540723 5.42152621571078e-09 0.256972282818825 0.189220286867016 MirTarget;miRNATAP -0.127676852440805 0.00818695003940969 NA NA NA hsa-miR-16-5p ABL2 1.00515772948091 5.33912942007619e-06 0.256972282818825 0.189220286867016 miRNAWalker2_validate;MirTarget;miRNATAP -0.202856217171167 0.00107003089832635 NA NA NA hsa-miR-17-3p ABL2 1.31126744284937 3.24768335024185e-07 0.256972282818825 0.189220286867016 mirMAP -0.224272385869413 1.69587241080135e-05 NA NA NA hsa-miR-186-5p ABL2 0.149964130725901 0.434709542998771 0.256972282818825 0.189220286867016 MirTarget;mirMAP -0.217656114063127 0.0032910565883837 NA NA NA hsa-miR-188-5p ABL2 1.35426907033843 0.00038346077691455 0.256972282818825 0.189220286867016 mirMAP -0.146842587008326 3.39462668407091e-05 NA NA NA hsa-miR-200a-5p ABL2 1.50371809098978 0.00263602434344863 0.256972282818825 0.189220286867016 mirMAP -0.123627216615741 4.36297682502794e-06 NA NA NA hsa-miR-200b-3p ABL2 0.974577911407732 0.0595020056914543 0.256972282818825 0.189220286867016 MirTarget -0.127091839436247 1.13067266492184e-06 NA NA NA hsa-miR-200b-5p ABL2 0.969871521250413 0.0530500454130183 0.256972282818825 0.189220286867016 mirMAP -0.155705724521061 2.69496443666133e-08 NA NA NA hsa-miR-200c-3p ABL2 1.28185685499076 0.00369777635539177 0.256972282818825 0.189220286867016 MirTarget -0.126227851217473 3.93942677207794e-05 NA NA NA hsa-miR-26a-5p ABL2 -0.384110714440647 0.0442498636014044 0.256972282818825 0.189220286867016 MirTarget;miRNATAP -0.308639749828198 2.53255430150103e-05 NA NA NA hsa-miR-26b-5p ABL2 -0.301646326928219 0.160081421968103 0.256972282818825 0.189220286867016 MirTarget;miRNATAP -0.327961986207562 3.23737281171828e-07 NA NA NA hsa-miR-29a-3p ABL2 -0.113012156986374 0.615005009685815 0.256972282818825 0.189220286867016 mirMAP -0.252278584226949 4.85002275990377e-05 NA NA NA hsa-miR-29c-3p ABL2 -1.62454036584589 5.38376515586029e-07 0.256972282818825 0.189220286867016 mirMAP -0.130430768818273 0.00168801857606421 NA NA NA hsa-miR-30b-5p ABL2 -0.430720743745757 0.0593564057320791 0.256972282818825 0.189220286867016 mirMAP -0.208960788231758 0.000632053732135908 NA NA NA hsa-miR-30d-3p ABL2 -0.545113326540761 0.0433733076874155 0.256972282818825 0.189220286867016 mirMAP -0.155688822318542 0.00252994574578852 NA NA NA hsa-miR-30d-5p ABL2 -0.5492586056147 0.0140125082460125 0.256972282818825 0.189220286867016 mirMAP;miRNATAP -0.232574056698164 0.000182595582031218 NA NA NA hsa-miR-30e-3p ABL2 -0.913131357083321 7.29096855615228e-06 0.256972282818825 0.189220286867016 mirMAP -0.251373354910351 0.000188720622625411 NA NA NA hsa-miR-335-5p ABL2 1.59953351087307 5.56170899867314e-05 0.256972282818825 0.189220286867016 mirMAP -0.172720213782381 2.44075734614013e-07 NA NA NA hsa-miR-33a-3p ABL2 0.347011402017138 0.321709379745392 0.256972282818825 0.189220286867016 mirMAP -0.15131704788893 0.000264994074589399 NA NA NA hsa-miR-378a-3p ABL2 -0.192828831363649 0.530795182107493 0.256972282818825 0.189220286867016 mirMAP -0.213189953132297 1.63533319838503e-06 NA NA NA hsa-miR-378c ABL2 -1.27752074861415 2.73676010235611e-05 0.256972282818825 0.189220286867016 mirMAP -0.247677238317546 1.16406908782845e-08 NA NA NA hsa-miR-429 ABL2 1.40182602301928 0.00900426780286475 0.256972282818825 0.189220286867016 MirTarget -0.132318154582583 1.07724396114953e-07 NA NA NA hsa-miR-500a-5p ABL2 0.00337014556047865 0.992120109131868 0.256972282818825 0.189220286867016 mirMAP -0.111396560045379 0.00635671297514772 NA NA NA hsa-miR-589-5p ABL2 0.702695092403762 0.00395772685954799 0.256972282818825 0.189220286867016 MirTarget;miRNATAP -0.151854847987028 0.00782302997610398 NA NA NA hsa-miR-590-3p ABL2 1.11654983899947 0.000160782154924864 0.256972282818825 0.189220286867016 PITA;mirMAP;miRNATAP -0.125461038740538 0.00684072405272723 NA NA NA hsa-miR-625-3p ABL2 -0.185298294014366 0.626215541224408 0.256972282818825 0.189220286867016 mirMAP -0.182685848863613 3.0148449176486e-07 NA NA NA hsa-miR-7-1-3p ABL2 0.709309110750947 0.0412301737463194 0.256972282818825 0.189220286867016 mirMAP -0.142107323382371 0.000330222667870904 NA NA NA hsa-miR-21-5p AKT2 1.75445050487988 2.41825549682022e-23 -0.0135478038511252 0.922701697200587 miRNAWalker2_validate -0.147206602823392 0.00352458167442573 NA NA NA hsa-miR-29b-3p AKT2 -0.230693226193598 0.367461626035234 -0.0135478038511252 0.922701697200587 MirTarget -0.141689777106604 0.000224365237662475 26512921;26564501;24076586 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3;The expression of miR-29b was significantly upregualted by cisplatin treatmentwhile its target gene AKT2 was downregulated;Furthermore a feed-back loop comprising of c-Myc miR-29 family and Akt2 were found in myeloid leukemogenesis ;; ovarian cancer;gastric cancer;acute myeloid leukemia hsa-miR-106b-5p AKT3 1.70863907461894 2.04074794107142e-08 -0.748577301508132 0.0693608036068007 miRNATAP -0.368902671357459 6.63579377990938e-05 NA NA NA hsa-miR-107 AKT3 0.904627575346218 4.67936495073904e-05 -0.748577301508132 0.0693608036068007 PITA;miRanda -0.596025797372068 4.38261497597827e-06 NA NA NA hsa-miR-15b-5p AKT3 1.62046407540723 5.42152621571078e-09 -0.748577301508132 0.0693608036068007 miRNATAP -0.359857777182961 0.000407223981183838 NA NA NA hsa-miR-16-5p AKT3 1.00515772948091 5.33912942007619e-06 -0.748577301508132 0.0693608036068007 miRNAWalker2_validate;miRTarBase;miRNATAP -0.473860841884761 0.000305952592817196 NA NA NA hsa-miR-17-3p AKT3 1.31126744284937 3.24768335024185e-07 -0.748577301508132 0.0693608036068007 miRNATAP -0.520864813647553 2.25932722443508e-06 NA NA NA hsa-miR-17-5p AKT3 1.65862087862483 8.45603406215941e-08 -0.748577301508132 0.0693608036068007 TargetScan;miRNATAP -0.276276453758938 0.00270096970703173 NA NA NA hsa-miR-29a-3p AKT3 -0.113012156986374 0.615005009685815 -0.748577301508132 0.0693608036068007 miRNATAP -0.408748871699734 0.00212322174807936 NA NA NA hsa-miR-29b-3p AKT3 -0.230693226193598 0.367461626035234 -0.748577301508132 0.0693608036068007 miRNATAP -0.338134432146425 0.00361456599882575 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-32-3p AKT3 0.583525764322974 0.11837203008551 -0.748577301508132 0.0693608036068007 mirMAP -0.324144417685552 0.000230218736536503 NA NA NA hsa-miR-320b AKT3 1.11183660885284 0.000497971211648503 -0.748577301508132 0.0693608036068007 PITA;miRanda;miRNATAP -0.263235906209639 0.00390234919135454 NA NA NA hsa-miR-335-3p AKT3 2.5197689063267 2.20084506976733e-09 -0.748577301508132 0.0693608036068007 mirMAP -0.224460236877792 0.000742588100170571 NA NA NA hsa-miR-33a-3p AKT3 0.347011402017138 0.321709379745392 -0.748577301508132 0.0693608036068007 mirMAP -0.376513667394311 1.68302152281553e-05 NA NA NA hsa-miR-362-3p AKT3 -0.0349414695893027 0.913780708043777 -0.748577301508132 0.0693608036068007 miRanda -0.37545416085904 3.60412362584734e-05 NA NA NA hsa-miR-362-5p AKT3 -0.354508685915981 0.354912078595613 -0.748577301508132 0.0693608036068007 PITA;TargetScan;miRNATAP -0.231850776707854 0.00252522310690117 NA NA NA hsa-miR-501-3p AKT3 0.731876211669996 0.0270421347018303 -0.748577301508132 0.0693608036068007 miRNATAP -0.389710500003727 8.30408434984544e-06 NA NA NA hsa-miR-502-3p AKT3 -0.16442685491191 0.557471818466728 -0.748577301508132 0.0693608036068007 miRNATAP -0.502835122914366 1.28261107693995e-06 NA NA NA hsa-miR-505-3p AKT3 0.82660100642669 0.00111666333288398 -0.748577301508132 0.0693608036068007 mirMAP -0.351999859841566 0.0023495079245673 22051041 We also find that Akt3 correlate inversely with miR-505 modulates drug sensitivity in MCF7-ADR breast cancer hsa-miR-548v AKT3 -0.156004387355895 0.708665170641638 -0.748577301508132 0.0693608036068007 miRNATAP -0.26608196493585 0.000310856014668821 NA NA NA hsa-miR-577 AKT3 0.911619788986754 0.2256062124148 -0.748577301508132 0.0693608036068007 mirMAP -0.230357457399908 2.14832389488646e-09 NA NA NA hsa-miR-616-5p AKT3 0.834052908652744 0.0347835664029363 -0.748577301508132 0.0693608036068007 mirMAP -0.265580906698402 0.000411824587413266 NA NA NA hsa-miR-429 ANGPT1 1.40182602301928 0.00900426780286475 -0.527270855014746 0.283336633574923 miRanda -0.303872006325128 1.59249703357909e-06 NA NA NA hsa-miR-129-5p ANGPT2 -2.56914016541176 2.36237896095709e-06 1.69586907431828 1.76346718161662e-07 MirTarget;miRanda -0.127754969681771 0.00317938631188512 NA NA NA hsa-miR-145-5p ANGPT2 -1.75133578902314 1.54965572197748e-05 1.69586907431828 1.76346718161662e-07 MirTarget;miRNATAP -0.219550526534805 0.00012074406146925 24384875;27570490 miR 145 functions as tumor suppressor and targets two oncogenes ANGPT2 and NEDD9 in renal cell carcinoma; We further validated those miR-145 targets two oncogenes ANGPT2 and NEDD9 in RCC;MiR 145 functions as a tumor suppressor via regulating angiopoietin 2 in pancreatic cancer cells; The direct action of miR-145 on Ang-2 was predicted by TargetScan and confirmed by luciferase report assay; The expression level of miR-145 was significantly lower and the expression levels of Ang-2 mRNA and protein was significantly higher in the more aggressive pancreatic cancer cells MiaPaCa-2 and Panc-1 when compared to that in BxPC3 cells; Overexpression of miR-145 in the BxPC3 MiaPaCa-2 and Panc-1 cells suppressed the cell invasion and colony formation ability and the expression level of Ang-2 protein in MiaPaCa-2 and Panc-1 cells was also suppressed after pre-miR-145 transfection; Intratumoral delivery of miR-145 inhibited the growth of pancreatic cancer xenografts and angiogenesis in vivo and also suppressed the expression level of angiopoietin-2 protein; MiR-145 functions as a tumor suppressor in pancreatic cancer cells by targeting Ang-2 for translation repression and thus suppresses pancreatic cancer cell invasion and growth which suggests that restoring of miR-145 may be a potential therapeutic target for pancreatic cancer ; kidney renal cell cancer;pancreatic cancer hsa-miR-664a-3p ANGPT2 -0.83041219170254 0.000136267547251167 1.69586907431828 1.76346718161662e-07 mirMAP -0.367845167537421 0.000759285521024805 NA NA NA hsa-miR-10a-3p ARF6 0.221754213874695 0.560576719784617 0.246970258949792 0.182026358438469 miRNATAP -0.113658134331174 0.00124016502057336 NA NA NA hsa-miR-181c-5p ARF6 0.336826967681288 0.112932307913601 0.246970258949792 0.182026358438469 MirTarget -0.180743597187775 0.00393157770315487 NA NA NA hsa-miR-181d-5p ARF6 0.65192727601808 0.0143398117228333 0.246970258949792 0.182026358438469 MirTarget -0.160895252535706 0.00106498240927946 NA NA NA hsa-miR-217 ARF6 -0.0121404731225336 0.980818372851502 0.246970258949792 0.182026358438469 miRanda -0.102896179399699 5.95038945572862e-05 NA NA NA hsa-miR-30a-3p ARF6 -1.73205137750899 3.2425754511091e-07 0.246970258949792 0.182026358438469 MirTarget;miRNATAP -0.138463804445952 0.000200698188941417 NA NA NA hsa-miR-30a-5p ARF6 -1.71922855140016 3.20574349285256e-07 0.246970258949792 0.182026358438469 miRNAWalker2_validate -0.155172983742766 3.2982677965923e-05 NA NA NA hsa-miR-338-3p ARF6 -0.959276231066179 0.0191473351014091 0.246970258949792 0.182026358438469 miRanda -0.140950289546581 6.65759029364067e-06 NA NA NA hsa-miR-338-5p ARF6 -1.19659203838734 0.0100316010080496 0.246970258949792 0.182026358438469 PITA -0.108512705866119 8.74766735282696e-05 NA NA NA hsa-let-7b-5p BCL2L1 0.0582902155815681 0.781400138984745 0.213751739166448 0.395782450784369 miRNATAP -0.314285217081765 0.000268924662830079 26915294;20347499 As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;The let 7 family of microRNAs inhibits Bcl xL expression and potentiates sorafenib induced apoptosis in human hepatocellular carcinoma; The effect of let-7 on Bcl-xL expression was examined by Western blot and a reporter assay; Microarray analysis followed by in silico target prediction identified let-7 microRNAs as being downregulated in Huh7 hepatoma cells in comparison with primary human hepatocytes as well as possessing a putative target site in the bcl-xl mRNA poor survival; lung cancer;liver cancer hsa-let-7c-5p BCL2L1 -0.503482361446512 0.206848395212976 0.213751739166448 0.395782450784369 miRNAWalker2_validate;miRTarBase -0.198493465039984 6.59628301755695e-06 20347499 Over-expression of let-7c or let-7g led to a clear decrease of Bcl-xL expression in Huh7 and HepG2 cell lines; Reporter assays revealed direct post-transcriptional regulation involving let-7c or let-7g and the 3'-untranslated region of bcl-xl mRNA liver cancer hsa-miR-149-5p BCL2L1 0.706277554734069 0.296848731347677 0.213751739166448 0.395782450784369 mirMAP -0.173000301400021 4.12180118165392e-12 NA NA NA hsa-miR-214-3p BCL2L1 1.01201534142544 0.00625092909225755 0.213751739166448 0.395782450784369 mirMAP -0.12678075713813 0.00823737366000966 NA NA NA hsa-miR-23b-3p BCL2L1 -0.286465516491361 0.18664668472995 0.213751739166448 0.395782450784369 miRNAWalker2_validate -0.389042865664013 2.23464331013867e-06 NA NA NA hsa-miR-192-3p BDNF 0.355565421687399 0.74117031340037 0.736006518564608 0.183812338919891 MirTarget;miRNATAP -0.106082522009255 0.00423859909260241 NA NA NA hsa-miR-29b-2-5p BDNF -1.7015307882027 2.84239251703401e-10 0.736006518564608 0.183812338919891 mirMAP -0.375479531938686 0.00761861774409137 NA NA NA hsa-miR-338-5p BDNF -1.19659203838734 0.0100316010080496 0.736006518564608 0.183812338919891 miRNATAP -0.30035007324931 0.000332002329074772 NA NA NA hsa-let-7i-5p CALM1 0.798954594465461 2.99735653959449e-05 -0.699799573984896 3.43181953797797e-05 miRNATAP -0.20010198631082 0.0016750787796402 NA NA NA hsa-miR-142-3p CALM1 1.32364054836498 0.0001537753622128 -0.699799573984896 3.43181953797797e-05 miRanda;miRNATAP -0.14927330430344 1.00310483680026e-05 NA NA NA hsa-miR-142-5p CALM1 1.55592486377018 6.69269968016779e-06 -0.699799573984896 3.43181953797797e-05 miRNATAP -0.100813389469362 0.00342020006267502 NA NA NA hsa-miR-15a-5p CALM1 1.03783090449383 7.40334108980898e-07 -0.699799573984896 3.43181953797797e-05 miRNATAP -0.169634673533134 0.00311309423279003 NA NA NA hsa-miR-16-2-3p CALM1 1.8048179609245 2.83095715136409e-09 -0.699799573984896 3.43181953797797e-05 mirMAP -0.156183793710648 4.21468080512849e-05 NA NA NA hsa-miR-16-5p CALM1 1.00515772948091 5.33912942007619e-06 -0.699799573984896 3.43181953797797e-05 miRNATAP -0.191258837965375 0.000431598947519458 NA NA NA hsa-miR-181a-5p CALM1 1.39227281909646 1.91689469974826e-09 -0.699799573984896 3.43181953797797e-05 miRNATAP -0.254593800285642 3.09341268557212e-07 NA NA NA hsa-miR-181b-5p CALM1 1.64216500592669 1.89228845300725e-08 -0.699799573984896 3.43181953797797e-05 miRNATAP -0.207224462233249 1.37177569061254e-07 NA NA NA hsa-miR-181c-5p CALM1 0.336826967681288 0.112932307913601 -0.699799573984896 3.43181953797797e-05 miRNATAP -0.280535176841362 8.95919801567663e-07 NA NA NA hsa-miR-186-5p CALM1 0.149964130725901 0.434709542998771 -0.699799573984896 3.43181953797797e-05 mirMAP -0.199087989544541 0.00218123497801578 NA NA NA hsa-miR-19a-3p CALM1 1.26669687448473 0.000105972838514412 -0.699799573984896 3.43181953797797e-05 miRNATAP -0.126217069724952 0.000552564707447059 NA NA NA hsa-miR-19b-3p CALM1 0.759818275708988 0.00652779573186786 -0.699799573984896 3.43181953797797e-05 miRNATAP -0.156105419596623 0.000310228608197249 NA NA NA hsa-miR-335-5p CALM1 1.59953351087307 5.56170899867314e-05 -0.699799573984896 3.43181953797797e-05 mirMAP -0.119717301835051 5.81072702990014e-05 NA NA NA hsa-miR-3614-3p CALM1 0.816988052098069 0.0143572924352078 -0.699799573984896 3.43181953797797e-05 miRNATAP -0.117449259037316 0.00180218504326298 NA NA NA hsa-miR-423-5p CALM1 0.832613878736338 0.000791321227103338 -0.699799573984896 3.43181953797797e-05 miRNATAP -0.130508059823451 0.00780798906127229 NA NA NA hsa-miR-576-5p CALM1 0.625714137488957 0.0417100301848969 -0.699799573984896 3.43181953797797e-05 mirMAP -0.125202512437334 0.00155312224911994 NA NA NA hsa-miR-7-1-3p CALM1 0.709309110750947 0.0412301737463194 -0.699799573984896 3.43181953797797e-05 mirMAP -0.101830554927932 0.00357811134682292 NA NA NA hsa-let-7a-3p CALM2 0.503048155002889 0.0411145454335299 0.3767614360415 0.00867326675713852 miRNATAP -0.108300657693279 0.00937190646166032 NA NA NA hsa-miR-27a-3p CALM3 1.29886998470345 2.68986118553486e-08 0.141715198019065 0.454364915387048 miRNATAP -0.225089901396031 4.73082325527579e-05 NA NA NA hsa-miR-27b-3p CALM3 0.0836323965901755 0.725273923274 0.141715198019065 0.454364915387048 miRNAWalker2_validate;miRNATAP -0.230884241724288 4.33708178689318e-05 NA NA NA hsa-miR-34c-5p CALM3 2.20632574870337 0.000379662996168678 0.141715198019065 0.454364915387048 miRanda -0.111010814804846 9.11519003194338e-08 NA NA NA hsa-miR-411-5p CALML4 0.0190472168701112 0.956112053787566 0.366496468551059 0.32957150045628 MirTarget -0.342578784146292 7.76377612169546e-06 NA NA NA hsa-miR-452-5p CALML4 2.08756506185889 0.000258095769002813 0.366496468551059 0.32957150045628 mirMAP -0.322781600207369 8.32245619850928e-14 NA NA NA hsa-miR-944 CALML4 3.33123095809751 0.0177835044930391 0.366496468551059 0.32957150045628 PITA;miRNATAP -0.221350795403046 1.30270726517397e-30 NA NA NA hsa-miR-152-3p CHUK 0.436002345388935 0.161701199884702 -0.111597771177896 0.436110414435051 MirTarget -0.173337618013613 3.78615463498576e-08 NA NA NA hsa-miR-195-5p CHUK -0.907998841926297 0.00150511564650591 -0.111597771177896 0.436110414435051 miRNAWalker2_validate;MirTarget -0.133199766126432 0.000124702259663161 NA NA NA hsa-miR-23a-3p CHUK 1.10685926969665 3.16223452471768e-08 -0.111597771177896 0.436110414435051 MirTarget -0.16996459977061 0.000556739825154491 NA NA NA hsa-miR-23b-3p CHUK -0.286465516491361 0.18664668472995 -0.111597771177896 0.436110414435051 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.186735010864747 6.42002077885917e-05 NA NA NA hsa-miR-342-3p CHUK 0.318119432680668 0.269150960124243 -0.111597771177896 0.436110414435051 miRanda -0.186912661037413 4.74504057766316e-08 NA NA NA hsa-miR-497-5p CHUK -0.801030912431774 0.00360386743876612 -0.111597771177896 0.436110414435051 MirTarget -0.109322835458534 0.00272843002977532 NA NA NA hsa-miR-106a-5p CSF1 -0.173255688252641 0.642872703263671 -0.306013328429031 0.339617855573793 miRNATAP -0.170469263289726 0.00529326868395722 NA NA NA hsa-miR-128-3p CSF1 0.98280381420517 5.77641850797209e-05 -0.306013328429031 0.339617855573793 MirTarget -0.292799890513823 0.00151811395185712 22909061 By mutations in putative miRNA targets in CSF-1 mRNA 3'UTR we identified a common target for both miR-128 and miR-152; We have also found that both miR-128 and miR-152 down-regulate CSF-1 mRNA and protein expression in ovarian cancer cells leading to decreased cell motility and adhesion in vitro two major aspects of the metastatic potential of cancer cells; Our results provide the evidence for a mechanism by which miR-128 and miR-152 down-regulate CSF-1 an important regulator of ovarian cancer motility ovarian cancer hsa-miR-130b-3p CSF1 1.32714007211004 4.78676252285191e-05 -0.306013328429031 0.339617855573793 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.245937304619252 0.000313814821079298 22005523 CSF-1 regulated by miR-130b was detected using Dual Luciferase Reporter system; CSF-1 expression was negatively associated with miR-130b level in ovarian tissues and cell lines; Luciferase assay validated CSF-1 is a direct target of miR-130b; Knock-down of CSF-1 sensitized ovarian cancer cells to anticancer drugs and could partially attenuate the resistance inducing effect of miR-130b inhibitors; Downregulation of miR-130b promotes the development of multidrug resistant ovarian cancer partially by targeting the 3'-UTR of CSF-1 and the silencing of miR-130b may be mediated by DNA methylation drug resistance ovarian cancer hsa-miR-15b-5p CSF1 1.62046407540723 5.42152621571078e-09 -0.306013328429031 0.339617855573793 miRNATAP -0.241835541353696 0.00223920403975309 NA NA NA hsa-miR-17-5p CSF1 1.65862087862483 8.45603406215941e-08 -0.306013328429031 0.339617855573793 TargetScan;miRNATAP -0.288380079977193 4.40947475236434e-05 NA NA NA hsa-miR-20a-5p CSF1 1.4503375861709 5.7813456424762e-07 -0.306013328429031 0.339617855573793 miRNATAP -0.284235533220314 0.000186701312465847 NA NA NA hsa-miR-23b-5p CSF1 0.608950043767916 0.0486466728330363 -0.306013328429031 0.339617855573793 MirTarget -0.256397065845335 0.000725420051962134 NA NA NA hsa-miR-301b-3p CSF1 1.10080095582241 0.0715568440482997 -0.306013328429031 0.339617855573793 MirTarget -0.156933717567782 0.00197124789187324 NA NA NA hsa-miR-429 CSF1 1.40182602301928 0.00900426780286475 -0.306013328429031 0.339617855573793 PITA;miRanda;miRNATAP -0.200936373891527 1.05202961632838e-06 NA NA NA hsa-miR-532-3p CSF1 0.552364451472481 0.0975490365586023 -0.306013328429031 0.339617855573793 MirTarget;PITA -0.182127653327354 0.00784442562115013 NA NA NA hsa-miR-940 CSF1 1.64406174271686 0.000690854900107004 -0.306013328429031 0.339617855573793 MirTarget;PITA;miRNATAP -0.195859539526611 0.000322515538656205 NA NA NA hsa-miR-96-5p CSF1 1.14243043653372 0.00942969392739105 -0.306013328429031 0.339617855573793 miRNATAP -0.263546897320587 5.7365562421308e-07 NA NA NA hsa-miR-107 CSF1R 0.904627575346218 4.67936495073904e-05 -1.02341409884128 0.0140396442947017 miRanda -0.545970040887892 3.70105416597969e-05 NA NA NA hsa-miR-339-5p CSF1R 0.770566566962108 0.00816529093411862 -1.02341409884128 0.0140396442947017 miRanda -0.274972569018597 0.00729433056987879 NA NA NA hsa-miR-629-3p CSF1R 1.40326397107309 9.7803063526732e-05 -1.02341409884128 0.0140396442947017 MirTarget -0.231742097251657 0.00448245856132303 NA NA NA hsa-miR-30c-2-3p EFNA1 -1.13954984520886 0.000846438233267901 0.996260300178003 0.000133763227919098 MirTarget -0.204058040213358 0.000166758058219795 NA NA NA hsa-miR-491-5p EFNA1 -0.693578126269305 0.0313646742330058 0.996260300178003 0.000133763227919098 miRanda -0.216902768525028 0.000258080701989054 NA NA NA hsa-miR-205-5p EFNA2 3.13520672931882 0.0293226471971167 2.57160457190072 0.0107529034045647 MirTarget -0.388362147927696 3.53243059913237e-17 NA NA NA hsa-miR-30a-5p EFNA3 -1.71922855140016 3.20574349285256e-07 2.02642067098231 2.3674027025848e-05 MirTarget;mirMAP;miRNATAP -0.575401972932312 3.41779536485916e-09 NA NA NA hsa-miR-30c-5p EFNA3 -0.983130268805942 4.60419218706127e-05 2.02642067098231 2.3674027025848e-05 MirTarget;mirMAP;miRNATAP -0.62663735860429 9.40739975448068e-06 NA NA NA hsa-miR-326 EFNA3 -0.429748586406214 0.2629894124021 2.02642067098231 2.3674027025848e-05 MirTarget;miRanda;miRNATAP -0.30939686435267 0.000721990584641849 NA NA NA hsa-miR-361-3p EFNA3 -0.126462931388735 0.566052688733137 2.02642067098231 2.3674027025848e-05 MirTarget;miRNATAP -0.437179664518529 0.00674849886378199 NA NA NA hsa-miR-140-5p EFNA5 0.208193069681326 0.303002433893804 -0.59268728009126 0.197442097474001 miRanda -0.456307446761147 0.00594394639667581 NA NA NA hsa-miR-186-5p EFNA5 0.149964130725901 0.434709542998771 -0.59268728009126 0.197442097474001 mirMAP -0.513291305425438 0.00337437925353359 NA NA NA hsa-miR-19a-3p EFNA5 1.26669687448473 0.000105972838514412 -0.59268728009126 0.197442097474001 miRNATAP -0.314103005278395 0.00144694992199416 NA NA NA hsa-miR-19b-3p EFNA5 0.759818275708988 0.00652779573186786 -0.59268728009126 0.197442097474001 miRNATAP -0.30347780852905 0.0097946885289395 NA NA NA hsa-miR-20a-3p EFNA5 1.13957127410163 0.000451087640268489 -0.59268728009126 0.197442097474001 mirMAP -0.282561710685476 0.00465124532672464 NA NA NA hsa-miR-2110 EFNA5 0.759864042760204 0.0723961390557655 -0.59268728009126 0.197442097474001 mirMAP;miRNATAP -0.239413573709544 0.00218631780518331 NA NA NA hsa-miR-335-3p EFNA5 2.5197689063267 2.20084506976733e-09 -0.59268728009126 0.197442097474001 mirMAP -0.350806591648546 1.54208048603757e-06 NA NA NA hsa-miR-335-5p EFNA5 1.59953351087307 5.56170899867314e-05 -0.59268728009126 0.197442097474001 miRNAWalker2_validate -0.316744466365194 7.88683717662051e-05 NA NA NA hsa-miR-338-3p EFNA5 -0.959276231066179 0.0191473351014091 -0.59268728009126 0.197442097474001 miRanda;miRNATAP -0.320173160906421 4.73048041641712e-05 NA NA NA hsa-miR-361-3p EFNA5 -0.126462931388735 0.566052688733137 -0.59268728009126 0.197442097474001 MirTarget -0.432615662418316 0.00428386030050904 NA NA NA hsa-miR-378a-3p EFNA5 -0.192828831363649 0.530795182107493 -0.59268728009126 0.197442097474001 miRNATAP -0.28783086443859 0.00730497879127635 NA NA NA hsa-miR-421 EFNA5 1.80720854070385 1.59709651202848e-07 -0.59268728009126 0.197442097474001 mirMAP -0.29532170698244 0.00130584115253054 NA NA NA hsa-miR-501-5p EFNA5 0.266919328110625 0.454779001968586 -0.59268728009126 0.197442097474001 mirMAP -0.289855132396456 0.00158892782436729 NA NA NA hsa-miR-577 EFNA5 0.911619788986754 0.2256062124148 -0.59268728009126 0.197442097474001 mirMAP -0.184859339355849 2.48787777636932e-05 NA NA NA hsa-miR-592 EFNA5 0.779567202789068 0.204498177014474 -0.59268728009126 0.197442097474001 mirMAP;miRNATAP -0.186532912805534 0.00104208053334826 NA NA NA hsa-miR-7-1-3p EFNA5 0.709309110750947 0.0412301737463194 -0.59268728009126 0.197442097474001 mirMAP -0.405165408258985 1.27841421738199e-05 NA NA NA hsa-miR-92a-3p EFNA5 1.2209325870225 6.8757197708107e-06 -0.59268728009126 0.197442097474001 miRNAWalker2_validate -0.437246871564517 0.000209421038310427 NA NA NA hsa-miR-107 EGFR 0.904627575346218 4.67936495073904e-05 0.168405729171091 0.73751794453199 miRanda -0.780624524284184 6.54393495762893e-07 NA NA NA hsa-miR-126-5p EGFR 0.41765430251855 0.0753161203651532 0.168405729171091 0.73751794453199 mirMAP -0.430024627428674 0.00524917462605061 NA NA NA hsa-miR-140-5p EGFR 0.208193069681326 0.303002433893804 0.168405729171091 0.73751794453199 miRanda -0.643161622365357 0.00034542548755441 NA NA NA hsa-miR-146a-5p EGFR 1.82051649415508 2.03651725047679e-05 0.168405729171091 0.73751794453199 miRNAWalker2_validate -0.280474680543866 0.000569416646908149 25242818;22161865;25596948;24895573;25417703;23555954;24839931;21632853 Interestingly re-expression of miR-146a inhibited the invasive capacity of Colo357 and Panc-1 PC cells with concomitant down-regulation of EGFR and IRAK-1; Most importantly we found that the treatment of PC cells with "natural agents" 33'-diinodolylmethane DIM or isoflavone led to an increase in the expression of miR-146a and consequently down-regulated the expression of EGFR MTA-2 IRAK-1 and NF-κB resulting in the inhibition of invasion of Colo357 and Panc-1 cells;MiR 146a suppresses tumor growth and progression by targeting EGFR pathway and in a p ERK dependent manner in castration resistant prostate cancer; Mechanistic studies revealed that miR-146a repressed the expression of EGFR through binding to its 3'-untranslated region; Our findings suggest that ubiquitous loss of miR-146a is a critical mechanism for overexpression of EGFR in CRPC which is crucial to better understanding the pathogenesis of CRPC;Furthermore the expressions of bax and cleaved-caspase-3 mainly were increased in control and overexpression miR-146a groups however the expression of EGFR was inverse; All the results demonstrated that quercetin exhibited excellent effect on inhibiting cell proliferation in human breast cancer cells which was performed by up-regulating miR-146a expression then via inducing apoptosis through caspase-3 activation and mitochondrial-dependent pathways and inhibiting invasion through down-regulating the expression of EGFR;Furthermore western blot showed that miR-146a mimic downregulated EGFR ERK1/2 and stat5 signalings; These effects were less potent compared to that of a siRNA targeting EGFR a known target gene of miR-146a; Moreover miR-146a mimic could enhance the cell growth inhibition and apoptosis induction impact of various EGFR targeting agents;Here we report a previously unrecognized posttranscriptional mechanism by which BRCA1 regulates EGFR expression through the induction of miR-146a; We show that BRCA1 binds to MIR146A promoter and activates transcription which in turn attenuates EGFR expression;In functional experiments miR-146a suppressed cell growth induced cellular apoptosis and inhibited EGFR downstream signaling in five NSCLC cell lines H358 H1650 H1975 HCC827 and H292 miR-146a also inhibited the migratory capacity of these NSCLC cells; On the other hand miR-146a enhanced the inhibition of cell proliferation by drugs targeting EGFR including both TKIs gefitinib erlotinib and afatinib and a monoclonal antibody cetuximab; Our results suggest that these effects of miR-146a are due to its targeting of EGFR and NF-κB signaling;Deregulation of miR 146a expression in a mouse model of pancreatic cancer affecting EGFR signaling; Treatment of PC cells with CDF a novel synthetic compound led to re-expression of miR-146a resulting in the down-regulation of EGFR expression; Further knock-down of miR-146a in AsPC-1 cells led to the up-regulation of EGFR expression and showed increased clonogenic growth; In addition knock-down of EGFR by EGFR siRNA transfection of parental AsPC-1 cells and AsPC-1 cells stably transfected with pre-miR-146a resulted in decreased invasive capacity which was further confirmed by reduced luciferase activity in cells transfected with pMIR-Luc reporter vector containing miR-146a binding site; Collectively these results suggest that the loss of expression of miR-146a is a fundamental mechanism for over-expression of EGFR signaling and that re-expression of miR-146a by CDF treatment could be useful in designing personalized strategy for the treatment of human PC;The regulation of EGFR and IRAK1 by miR-146a was examined with miR-146a-transfected gastric cancer cells; Ectopic expression of miR-146a inhibited migration and invasion and downregulated EGFR and IRAK1 expression in gastric cancer cells; MiR-146a targeting of EGFR and IRAK1 is an independent prognostic factor in gastric cancer cases ;progression;;;;;; pancreatic cancer;prostate cancer;breast cancer;liver cancer;breast cancer;lung squamous cell cancer;pancreatic cancer;gastric cancer hsa-miR-186-5p EGFR 0.149964130725901 0.434709542998771 0.168405729171091 0.73751794453199 mirMAP -0.543315983386011 0.00447337739548099 NA NA NA hsa-miR-188-5p EGFR 1.35426907033843 0.00038346077691455 0.168405729171091 0.73751794453199 mirMAP -0.351646013165135 0.000124637708877987 NA NA NA hsa-miR-192-3p EGFR 0.355565421687399 0.74117031340037 0.168405729171091 0.73751794453199 mirMAP -0.206727639222232 1.36090223856721e-10 NA NA NA hsa-miR-192-5p EGFR 0.0809146624034405 0.941057093528709 0.168405729171091 0.73751794453199 mirMAP -0.226019181220992 1.67449171990161e-13 NA NA NA hsa-miR-194-3p EGFR 0.259420201261466 0.821811295418686 0.168405729171091 0.73751794453199 MirTarget -0.203898575114252 6.68731990591179e-12 NA NA NA hsa-miR-200a-3p EGFR 0.717826667295984 0.193912116506827 0.168405729171091 0.73751794453199 MirTarget -0.169331211945448 0.00867601958667097 26184032;19671845 MicroRNA 200a Targets EGFR and c Met to Inhibit Migration Invasion and Gefitinib Resistance in Non Small Cell Lung Cancer; In this study we found that miR-200a is downregulated in NSCLC cells where it directly targets the 3'-UTR of both EGFR and c-Met mRNA; Overexpression of miR-200a in NSCLC cells significantly downregulates both EGFR and c-Met levels and severely inhibits cell migration and invasion;Protein expression and signaling pathway modulation as well as intracellular distribution of EGFR and ERRFI-1 were validated through Western blot analysis and confocal microscopy whereas ERRFI-1 direct target of miR-200 members was validated by using the wild-type and mutant 3'-untranslated region/ERRFI-1/luciferse reporters; We identified a tight association between the expression of miRNAs of the miR-200 family epithelial phenotype and sensitivity to EGFR inhibitors-induced growth inhibition in bladder carcinoma cell lines; The changes in EGFR sensitivity by silencing or forced expression of ERRFI-1 or by miR-200 expression have also been validated in additional cell lines UMUC5 and T24; Members of the miR-200 family appear to control the EMT process and sensitivity to EGFR therapy in bladder cancer cells and the expression of miR-200 is sufficient to restore EGFR dependency at least in some of the mesenchymal bladder cancer cells drug resistance;cell migration; lung squamous cell cancer;bladder cancer hsa-miR-29b-2-5p EGFR -1.7015307882027 2.84239251703401e-10 0.168405729171091 0.73751794453199 mirMAP -0.3910017356137 0.00207778215894223 NA NA NA hsa-miR-30d-3p EGFR -0.545113326540761 0.0433733076874155 0.168405729171091 0.73751794453199 mirMAP -0.407148961073724 0.00219111229801308 NA NA NA hsa-miR-320b EGFR 1.11183660885284 0.000497971211648503 0.168405729171091 0.73751794453199 miRanda;mirMAP -0.332140716516881 0.0026979597411761 NA NA NA hsa-miR-335-5p EGFR 1.59953351087307 5.56170899867314e-05 0.168405729171091 0.73751794453199 miRNAWalker2_validate -0.398979814842028 4.4125849451091e-06 NA NA NA hsa-miR-340-5p EGFR -0.164941927483643 0.529910509321278 0.168405729171091 0.73751794453199 mirMAP -0.501426550811941 0.000243508571779912 NA NA NA hsa-miR-362-5p EGFR -0.354508685915981 0.354912078595613 0.168405729171091 0.73751794453199 mirMAP -0.432765239197852 2.36063976575942e-06 NA NA NA hsa-miR-375 EGFR -2.94506033785642 0.00570147601654791 0.168405729171091 0.73751794453199 miRanda -0.189586479112383 2.94006132397572e-09 NA NA NA hsa-miR-378c EGFR -1.27752074861415 2.73676010235611e-05 0.168405729171091 0.73751794453199 mirMAP -0.494126324357503 1.44640511557456e-05 NA NA NA hsa-miR-501-5p EGFR 0.266919328110625 0.454779001968586 0.168405729171091 0.73751794453199 mirMAP -0.499445439422852 3.55760656495929e-07 NA NA NA hsa-miR-577 EGFR 0.911619788986754 0.2256062124148 0.168405729171091 0.73751794453199 mirMAP -0.181043665182683 0.000164650893742774 NA NA NA hsa-miR-7-1-3p EGFR 0.709309110750947 0.0412301737463194 0.168405729171091 0.73751794453199 mirMAP -0.453112022139855 7.47168008914619e-06 NA NA NA hsa-miR-7-5p EGFR 1.63575693499363 0.0124424214624534 0.168405729171091 0.73751794453199 miRNAWalker2_validate;miRTarBase;MirTarget -0.267933940433673 1.42488777071465e-06 26708917;23115635;25503932;21712475;25334070;25532106;27203220;25862909;24816687;20978205;24603851;24573489;25289099;23227519 In addition the experimental data also suggest that miR-7 can interfere with EGFR mRNA translation; In addition miR-7 may function by interfering with EGFR mRNA translation but not degradation;Several studies have demonstrated that microRNA-7 miR-7 regulates EGFR expression and Akt activity in a range of cancer cell types via its specific interaction with the EGFR mRNA 3'-untranslated region 3'-UTR; Together these data support the coordinate regulation of Akt signaling by miR-7 in HNC cells and suggest the therapeutic potential of miR-7 alone or in combination with EGFR TKIs in this disease;The potential for miR-7 to act as a tumor suppressor by coordinately regulating the epidermal growth factor receptor EGFR signaling pathway at several levels was examined; We investigated the tumor inhibitory effect of miR-7 in CRC with particular focus on the relationship between miR-7 and the EGFR pathway; The regulation of EGFR by miR-7 was examined with miR-7 precursor-transfected cells; Furthermore we investigated whether miR-7 suppresses proliferation of CRC cells in combination with cetuximab a monoclonal antibody against EGFR; In vitro assays showed that EGFR and RAF-1 are direct targets of miR-7 which potently suppressed the proliferation of CRC cells and interestingly that the growth inhibitory effect of each of these was enhanced by cetuximab;To overcome the resistance we focused on EGFR suppression using microRNA-7 miR-7 targeting multiple sites in the 3'-untranslated region of EGFR mRNA;Furthermore inhibition of EGFR showed similar effects to miR-7 enforcement in 3LL cells; Taken together these findings revealed that miR-7 acts as an antitumor miRNA in 3LL by targeting and suppressing the expression of both EGFR and RAF-1 oncogenes;MiR-7 inhibited MCF-7/HER2Δ16 cell migration through a mechanism involving suppression of the miR-7 target gene EGFR; In contrast miR-7 inhibition of MCF-7/HER2Δ16 cell proliferation involved a pathway where miR-7 expression resulted in the inactivation of Src kinase independent of suppressed EGFR expression; Also independent of EGFR suppression reestablished miR-7 expression sensitized refractory MCF-7/HER2Δ16 cells to trastuzumab; We propose that miR-7 regulated pathways including EGFR and Src kinase represent targets for the therapeutic intervention of refractory and metastatic HER2Δ16 driven breast cancer;microRNA-7-5p miR-7-5p is a tumor suppressor in multiple cancer types and inhibits growth and invasion by suppressing expression and activity of the epidermal growth factor receptor EGFR signaling pathway;miR-7 overexpression correlated with diminished BCL2 expression but there was no relationship between miR-7 and EGFR expression neither in tumour samples nor in the cell lines; Of the two postulated miR-7 target genes we examined BCL2 but not EGFR seems to be a possible miR-7 target in OC;In recent years mounting evidence indicates that EGFR is a direct and functional target of miR-7; In this study we found that miR-7 expression was significantly downregulated in highly metastatic epithelial ovarian cancer EOC cell lines and metastatic tissues whereas the expression of EGFR correlated positively with metastasis in both EOC patients and cell lines; Finally the expression of miR-7 and EGFR in primary EOC with matched metastasis tissues was explored; It was showed that miR-7 is inversely correlated with EGFR; Taken together our results suggested that miR-7 inhibited tumor metastasis and reversed EMT through AKT and ERK1/2 pathway inactivation by reducing EGFR expression in EOC cell lines;In this study we report the discovery and mechanistic characterization of the miRNA miR-7 as an oncogenic "oncomiR" and its role as a key mediator of EGFR signaling in lung cancer cells;We show that microRNA-7 miR-7 is a common regulator of the phosphoinositide-3-kinase PI3K/ATK and Raf/mitogen-activated protein kinase kinase MEK/extracellular signal-regulated kinase ERK pathways both of which are launched by EGFR through its two direct targets the transcription factors PI3K and Raf-1 respectively; We conclude that miR-7 is a potential tumor suppressor in glioblastoma that acts by targeting multiple oncogenes related to the downstream pathway of EGFR and may serve as a novel therapeutic target for malignant gliomas;Further study will investigate miR-7 in the regulation of EGFR expression in vitro and in vivo;Pretreatment of miR-7 mimics enhanced the PTX-mediated downregulation of epidermal growth factor receptor EGFR in NSCLC cells;We identified miR-7 as the important miRNA associated with estrogen actions in these cells and further examined the changes of estrogen-dependent EGFR expression by miR-7 in ER-positive or -negative breast carcinoma cell lines including MCF-7; We also evaluated the correlation between miR-7 and EGFR expression in breast carcinoma cells derived from 21 patients using laser capture microdissection combined with quantitative reverse transcriptase-PCR; miR-7 was reported to suppress epidermal growth factor receptor EGFR expression in several human malignancies; Transfection of miR-7 significantly suppressed EGFR mRNA levels in MCF-7 cells; We also evaluated the status of miR-7 in breast carcinoma tissues but the correlation between the status of miR-7 and EGFR in carcinoma cells isolated by laser capture microscopy was not detected; These results suggest that miR-7 may play a role in the development of resistance to endocrine therapy in breast cancer patients through regulating EGFR expression of carcinoma cells ;;;drug resistance;;cell migration;;;metastasis;;malignant trasformation;;;drug resistance esophageal cancer;head and neck cancer;colorectal cancer;lung cancer;lung cancer;breast cancer;melanoma;ovarian cancer;ovarian cancer;lung cancer;glioblastoma;gastric cancer;lung squamous cell cancer;breast cancer hsa-miR-877-5p EGFR 2.17859965442336 1.03593450648516e-07 0.168405729171091 0.73751794453199 mirMAP -0.228987457354068 0.00665763782285166 NA NA NA hsa-miR-125a-5p EPHA2 -0.878090699011564 0.000213630844319685 1.1792195104295 0.00132403133641615 miRanda -0.306021671901184 0.00595912459051825 NA NA NA hsa-miR-1180-3p ETS1 1.48314593652652 6.01008168449525e-05 0.00804260183398675 0.979519418921508 MirTarget -0.294832688113107 3.3205498589023e-07 NA NA NA hsa-miR-125b-2-3p ETS1 -0.236995187284862 0.63161659167442 0.00804260183398675 0.979519418921508 mirMAP -0.158662257135776 0.000397418879837426 NA NA NA hsa-miR-130b-5p ETS1 0.701350393759937 0.0510142718395002 0.00804260183398675 0.979519418921508 MirTarget -0.220258809829416 0.000334154001913892 NA NA NA hsa-miR-141-3p ETS1 1.45548825076434 0.00115958850961764 0.00804260183398675 0.979519418921508 mirMAP -0.208201220904564 1.64288700946034e-05 NA NA NA hsa-miR-141-5p ETS1 2.07543489990205 6.42575039070838e-06 0.00804260183398675 0.979519418921508 mirMAP -0.181407675147701 0.000101787115395022 NA NA NA hsa-miR-193b-3p ETS1 0.281752012268679 0.451258902263119 0.00804260183398675 0.979519418921508 miRNAWalker2_validate;miRTarBase -0.2264800245885 0.000125999660788512 20655737 CCND1 and ETS1 were revealed to be regulated by miR-193b directly liver cancer hsa-miR-200c-3p ETS1 1.28185685499076 0.00369777635539177 0.00804260183398675 0.979519418921508 MirTarget;miRNATAP -0.24590279634176 4.52720630680018e-07 NA NA NA hsa-miR-23a-3p ETS1 1.10685926969665 3.16223452471768e-08 0.00804260183398675 0.979519418921508 mirMAP -0.35325766253037 0.00119549650279217 NA NA NA hsa-miR-23b-3p ETS1 -0.286465516491361 0.18664668472995 0.00804260183398675 0.979519418921508 mirMAP -0.526226583920908 2.39405508158625e-07 NA NA NA hsa-miR-27b-5p ETS1 0.680479953627235 0.0149700717026754 0.00804260183398675 0.979519418921508 MirTarget;miRNATAP -0.266295409832662 0.0007880726853705 NA NA NA hsa-miR-3065-5p ETS1 -0.241623656423063 0.633116553078159 0.00804260183398675 0.979519418921508 MirTarget;miRNATAP -0.18981041248104 1.90584358346707e-05 NA NA NA hsa-miR-365a-3p ETS1 -0.891537000455889 0.0025537650440002 0.00804260183398675 0.979519418921508 MirTarget -0.274944431690411 0.000220343553801154 NA NA NA hsa-miR-429 ETS1 1.40182602301928 0.00900426780286475 0.00804260183398675 0.979519418921508 MirTarget;PITA;miRanda;miRNATAP -0.132019036371168 0.00124150056450957 NA NA NA hsa-miR-769-5p ETS1 1.14821899306381 1.27143750879772e-06 0.00804260183398675 0.979519418921508 miRNATAP -0.560896515893524 2.60536189079668e-10 NA NA NA hsa-miR-9-5p ETS1 -0.195328736653048 0.761470692992178 0.00804260183398675 0.979519418921508 miRNAWalker2_validate;miRTarBase;miRNATAP -0.158615093339672 2.78124119444264e-06 NA NA NA hsa-miR-940 ETS1 1.64406174271686 0.000690854900107004 0.00804260183398675 0.979519418921508 MirTarget;miRNATAP -0.237142324755217 6.72645667205475e-06 NA NA NA hsa-miR-218-5p ETS2 -0.987730614742492 0.0108295837207062 0.379740413922286 0.150517864790524 miRNAWalker2_validate -0.165332460879367 0.000557070854931994 NA NA NA hsa-miR-340-5p ETS2 -0.164941927483643 0.529910509321278 0.379740413922286 0.150517864790524 mirMAP -0.211948631144571 0.00334883806375364 NA NA NA hsa-miR-9-3p ETS2 0.330346058941473 0.541111939982661 0.379740413922286 0.150517864790524 miRNATAP -0.103704133672869 0.00411892620919854 NA NA NA hsa-miR-92b-3p FASLG 1.33518446513417 1.45350885391576e-06 0.493896235569131 0.390001245956277 miRNATAP -0.542744180708012 0.000155394781632395 NA NA NA hsa-miR-126-5p FGF1 0.41765430251855 0.0753161203651532 -0.160234396361762 0.733972871379557 mirMAP -0.59094523029959 3.50264864833946e-05 NA NA NA hsa-miR-16-1-3p FGF1 1.43227522002564 3.70920454953168e-08 -0.160234396361762 0.733972871379557 mirMAP -0.415017127195873 0.000891606226757529 NA NA NA hsa-miR-186-5p FGF1 0.149964130725901 0.434709542998771 -0.160234396361762 0.733972871379557 mirMAP -0.802927092384163 5.33712623622096e-06 NA NA NA hsa-miR-18a-5p FGF1 2.20211504140984 1.78678887916334e-09 -0.160234396361762 0.733972871379557 MirTarget -0.427564859159038 6.45322365688328e-07 NA NA NA hsa-miR-222-5p FGF1 1.87968474330782 1.11743009485711e-06 -0.160234396361762 0.733972871379557 MirTarget -0.328069555060374 8.83297301332189e-05 NA NA NA hsa-miR-26b-3p FGF1 -0.0103961389461977 0.965770899625511 -0.160234396361762 0.733972871379557 MirTarget -0.614591765464955 8.91145535430066e-06 NA NA NA hsa-miR-29a-5p FGF1 0.585084040404152 0.023014129158495 -0.160234396361762 0.733972871379557 mirMAP -0.604881337368894 2.58167935202965e-06 NA NA NA hsa-miR-320a FGF1 0.593888711838028 0.011897419390526 -0.160234396361762 0.733972871379557 miRanda -0.386072945122806 0.00701900096114403 NA NA NA hsa-miR-320b FGF1 1.11183660885284 0.000497971211648503 -0.160234396361762 0.733972871379557 miRanda -0.368173004233106 0.000368398615653149 NA NA NA hsa-miR-326 FGF1 -0.429748586406214 0.2629894124021 -0.160234396361762 0.733972871379557 miRanda;miRNATAP -0.385294600510288 9.62075997895276e-06 NA NA NA hsa-miR-330-5p FGF1 0.488365986827708 0.0512207630808233 -0.160234396361762 0.733972871379557 miRanda;miRNATAP -0.490680892266321 0.000251789498451697 NA NA NA hsa-miR-429 FGF1 1.40182602301928 0.00900426780286475 -0.160234396361762 0.733972871379557 miRNATAP -0.323262102446773 7.92592247701929e-08 NA NA NA hsa-miR-484 FGF1 0.71327898984355 0.00233605130771196 -0.160234396361762 0.733972871379557 MirTarget;PITA;miRNATAP -0.408471643921956 0.00445789085377771 NA NA NA hsa-miR-532-3p FGF1 0.552364451472481 0.0975490365586023 -0.160234396361762 0.733972871379557 miRNATAP -0.744864947914853 2.30927245315596e-15 NA NA NA hsa-miR-550a-5p FGF1 2.27360629906903 2.14504977831873e-07 -0.160234396361762 0.733972871379557 MirTarget -0.412011719251591 1.06463288268876e-08 NA NA NA hsa-miR-590-5p FGF1 1.04171442093217 0.000272475544954865 -0.160234396361762 0.733972871379557 MirTarget;miRanda;miRNATAP -0.411316166846436 0.00036918107931291 NA NA NA hsa-miR-625-5p FGF1 0.537211086526376 0.203801009380384 -0.160234396361762 0.733972871379557 MirTarget -0.597908728237488 7.37909450819918e-16 NA NA NA hsa-miR-629-5p FGF1 1.06377074768516 0.000536624707722274 -0.160234396361762 0.733972871379557 MirTarget -0.349957209459157 0.00121021361741485 NA NA NA hsa-miR-7-5p FGF1 1.63575693499363 0.0124424214624534 -0.160234396361762 0.733972871379557 miRNAWalker2_validate -0.334571255736156 4.63756500683767e-11 NA NA NA hsa-let-7f-5p FGF11 0.634633924115866 0.0344982923411787 1.34606246397032 0.0313874796480627 mirMAP;miRNATAP -0.594039289750789 5.85711011149972e-05 NA NA NA hsa-let-7g-5p FGF11 0.325297685027927 0.241142963826631 1.34606246397032 0.0313874796480627 mirMAP;miRNATAP -0.875110015083308 3.01548567374744e-08 NA NA NA hsa-miR-10a-5p FGF11 -0.470861534765518 0.148803248989189 1.34606246397032 0.0313874796480627 mirMAP -0.839577254558606 2.06461410522248e-10 NA NA NA hsa-miR-217 FGF11 -0.0121404731225336 0.980818372851502 1.34606246397032 0.0313874796480627 PITA;miRanda -0.251553843688479 0.00449992982096522 NA NA NA hsa-miR-326 FGF11 -0.429748586406214 0.2629894124021 1.34606246397032 0.0313874796480627 MirTarget;PITA;miRanda;miRNATAP -0.444845744428783 0.000143421345045733 NA NA NA hsa-miR-335-5p FGF11 1.59953351087307 5.56170899867314e-05 1.34606246397032 0.0313874796480627 miRNAWalker2_validate;mirMAP -0.384291765399063 0.000482054927218443 NA NA NA hsa-miR-532-3p FGF11 0.552364451472481 0.0975490365586023 1.34606246397032 0.0313874796480627 mirMAP -0.60511003013694 4.75511871948254e-06 NA NA NA hsa-let-7f-1-3p FGF12 1.28704406797397 1.17954701106157e-06 -0.587357499262027 0.310516155638288 MirTarget -0.500961231356776 0.000998540142849314 NA NA NA hsa-miR-29a-5p FGF12 0.585084040404152 0.023014129158495 -0.587357499262027 0.310516155638288 MirTarget -0.561752160653773 0.000457570295243942 NA NA NA hsa-let-7f-1-3p FGF13 1.28704406797397 1.17954701106157e-06 -2.34574028365922 0.000183807352189951 MirTarget -0.563169375210783 0.000773915454703851 NA NA NA hsa-miR-141-3p FGF13 1.45548825076434 0.00115958850961764 -2.34574028365922 0.000183807352189951 TargetScan -0.419319186157982 2.18410603313764e-05 NA NA NA hsa-miR-200a-5p FGF13 1.50371809098978 0.00263602434344863 -2.34574028365922 0.000183807352189951 MirTarget;miRNATAP -0.316435602783381 0.000388466610194628 NA NA NA hsa-miR-200b-5p FGF13 0.969871521250413 0.0530500454130183 -2.34574028365922 0.000183807352189951 MirTarget -0.346419909837961 0.000222834092725641 NA NA NA hsa-miR-31-3p FGF13 0.474904754927656 0.506866261575484 -2.34574028365922 0.000183807352189951 miRNATAP -0.216224775700072 0.000656063150041637 NA NA NA hsa-miR-3682-3p FGF13 1.96838261925327 4.94885331227292e-06 -2.34574028365922 0.000183807352189951 MirTarget -0.406979633607707 0.000829055016383721 NA NA NA hsa-miR-429 FGF13 1.40182602301928 0.00900426780286475 -2.34574028365922 0.000183807352189951 miRNATAP -0.296325455439465 0.000372916450321645 NA NA NA hsa-miR-455-5p FGF13 1.20462751989145 6.74386011867484e-05 -2.34574028365922 0.000183807352189951 PITA;miRanda -0.492592516788581 0.000853952308418692 NA NA NA hsa-miR-590-3p FGF13 1.11654983899947 0.000160782154924864 -2.34574028365922 0.000183807352189951 miRanda -0.496872134281738 0.00103030244047749 NA NA NA hsa-miR-7-1-3p FGF13 0.709309110750947 0.0412301737463194 -2.34574028365922 0.000183807352189951 MirTarget;mirMAP -0.473759888075165 0.000258502260079092 NA NA NA hsa-miR-421 FGF14 1.80720854070385 1.59709651202848e-07 -2.26824495321978 0.000644201162802339 miRanda -0.51290819363414 0.000127157329894553 NA NA NA hsa-miR-590-3p FGF14 1.11654983899947 0.000160782154924864 -2.26824495321978 0.000644201162802339 miRanda -0.775153716412423 8.24216834793137e-07 NA NA NA hsa-miR-96-5p FGF14 1.14243043653372 0.00942969392739105 -2.26824495321978 0.000644201162802339 TargetScan -0.326435839133923 0.00402772700697129 NA NA NA hsa-miR-16-5p FGF18 1.00515772948091 5.33912942007619e-06 -0.701320708357095 0.262070500539484 miRNATAP -0.544910968247721 0.00650462011718626 NA NA NA hsa-miR-424-5p FGF18 1.08509868581983 0.000420473853818268 -0.701320708357095 0.262070500539484 miRNATAP -0.446614957034455 0.0018153474746596 NA NA NA hsa-miR-590-5p FGF18 1.04171442093217 0.000272475544954865 -0.701320708357095 0.262070500539484 miRanda;miRNATAP -0.766369227739518 3.8382097156196e-07 NA NA NA hsa-miR-9-5p FGF18 -0.195328736653048 0.761470692992178 -0.701320708357095 0.262070500539484 miRNATAP -0.237173048014931 0.000555869006551748 NA NA NA hsa-let-7a-3p FGF2 0.503048155002889 0.0411145454335299 -1.87861117290298 0.000125445679104344 mirMAP -0.410539117311516 0.00473622063740347 NA NA NA hsa-let-7b-3p FGF2 0.21838629112113 0.296038413622566 -1.87861117290298 0.000125445679104344 mirMAP -0.469514467711896 0.00680853109557966 NA NA NA hsa-let-7f-1-3p FGF2 1.28704406797397 1.17954701106157e-06 -1.87861117290298 0.000125445679104344 mirMAP -0.595048658334427 4.14210020217409e-06 NA NA NA hsa-miR-103a-3p FGF2 0.840525139266028 5.83536475789158e-07 -1.87861117290298 0.000125445679104344 miRNAWalker2_validate;MirTarget;miRNATAP -0.939824662070765 6.5144907085955e-06 NA NA NA hsa-miR-107 FGF2 0.904627575346218 4.67936495073904e-05 -1.87861117290298 0.000125445679104344 MirTarget;PITA;miRanda;miRNATAP -0.633691610533513 5.77496353910729e-05 NA NA NA hsa-miR-15a-5p FGF2 1.03783090449383 7.40334108980898e-07 -1.87861117290298 0.000125445679104344 MirTarget;miRNATAP -0.723624902429406 1.17476403328068e-05 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-3p FGF2 1.75738933306437 3.00554466232543e-08 -1.87861117290298 0.000125445679104344 mirMAP -0.601578664515957 9.71241978321172e-09 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-5p FGF2 1.62046407540723 5.42152621571078e-09 -1.87861117290298 0.000125445679104344 MirTarget;miRNATAP -0.727556694335382 9.63850854162267e-10 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-1-3p FGF2 1.43227522002564 3.70920454953168e-08 -1.87861117290298 0.000125445679104344 mirMAP -0.533569195692814 4.82742810832383e-05 NA NA NA hsa-miR-16-2-3p FGF2 1.8048179609245 2.83095715136409e-09 -1.87861117290298 0.000125445679104344 mirMAP -0.582691850054445 1.0626071080659e-07 NA NA NA hsa-miR-16-5p FGF2 1.00515772948091 5.33912942007619e-06 -1.87861117290298 0.000125445679104344 miRNAWalker2_validate;MirTarget;miRNATAP -0.87728356493459 1.36815119437221e-08 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-186-5p FGF2 0.149964130725901 0.434709542998771 -1.87861117290298 0.000125445679104344 miRNAWalker2_validate;mirMAP -0.536525732490695 0.00470973709226905 NA NA NA hsa-miR-192-5p FGF2 0.0809146624034405 0.941057093528709 -1.87861117290298 0.000125445679104344 miRNAWalker2_validate -0.100431705795905 0.00182203175890127 NA NA NA hsa-miR-19b-1-5p FGF2 1.38738648038895 1.3113681938066e-06 -1.87861117290298 0.000125445679104344 mirMAP -0.540056441979374 5.90790389026898e-06 NA NA NA hsa-miR-200b-3p FGF2 0.974577911407732 0.0595020056914543 -1.87861117290298 0.000125445679104344 mirMAP -0.35358155461024 1.0502797949384e-07 NA NA NA hsa-miR-200c-3p FGF2 1.28185685499076 0.00369777635539177 -1.87861117290298 0.000125445679104344 mirMAP -0.459255722541169 2.21550497680624e-09 NA NA NA hsa-miR-20a-3p FGF2 1.13957127410163 0.000451087640268489 -1.87861117290298 0.000125445679104344 mirMAP -0.635980126804227 1.03782626210616e-09 NA NA NA hsa-miR-21-3p FGF2 1.75245546017565 2.36505176715025e-10 -1.87861117290298 0.000125445679104344 mirMAP -0.541952936598777 7.7895313994942e-06 NA NA NA hsa-miR-21-5p FGF2 1.75445050487988 2.41825549682022e-23 -1.87861117290298 0.000125445679104344 mirMAP -0.484524479326667 0.00821705219155879 NA NA NA hsa-miR-215-5p FGF2 0.715250240418615 0.573784317311889 -1.87861117290298 0.000125445679104344 miRNAWalker2_validate -0.104771518281948 0.000141751804794456 NA NA NA hsa-miR-221-3p FGF2 1.33496247538338 3.82022531235275e-07 -1.87861117290298 0.000125445679104344 mirMAP -0.544428779797939 3.02629502512127e-05 NA NA NA hsa-miR-222-3p FGF2 1.39382731585819 9.98182478024671e-07 -1.87861117290298 0.000125445679104344 mirMAP -0.541204112402845 6.44319127167856e-06 NA NA NA hsa-miR-29a-5p FGF2 0.585084040404152 0.023014129158495 -1.87861117290298 0.000125445679104344 mirMAP -0.424035558508381 0.00219032018724374 NA NA NA hsa-miR-330-3p FGF2 0.798460296022179 0.00746538156533435 -1.87861117290298 0.000125445679104344 mirMAP -0.498128953238189 2.14033471411407e-05 NA NA NA hsa-miR-335-3p FGF2 2.5197689063267 2.20084506976733e-09 -1.87861117290298 0.000125445679104344 mirMAP -0.417269866841731 1.09046144483422e-07 NA NA NA hsa-miR-335-5p FGF2 1.59953351087307 5.56170899867314e-05 -1.87861117290298 0.000125445679104344 miRNATAP -0.323054850441658 0.000208841445593432 NA NA NA hsa-miR-3662 FGF2 1.82780708047676 0.0054036501346178 -1.87861117290298 0.000125445679104344 mirMAP -0.212606715986015 0.00207695589115596 NA NA NA hsa-miR-3682-3p FGF2 1.96838261925327 4.94885331227292e-06 -1.87861117290298 0.000125445679104344 mirMAP -0.621299624827262 8.40451860827003e-12 NA NA NA hsa-miR-424-5p FGF2 1.08509868581983 0.000420473853818268 -1.87861117290298 0.000125445679104344 MirTarget;miRNATAP -0.473116310929624 2.79114365346124e-05 NA NA NA hsa-miR-429 FGF2 1.40182602301928 0.00900426780286475 -1.87861117290298 0.000125445679104344 mirMAP -0.389653476745427 6.14878920514716e-10 NA NA NA hsa-miR-503-5p FGF2 1.88558728489534 2.26317868368257e-06 -1.87861117290298 0.000125445679104344 miRNAWalker2_validate -0.328905971783003 0.000129296346907329 NA NA NA hsa-miR-577 FGF2 0.911619788986754 0.2256062124148 -1.87861117290298 0.000125445679104344 mirMAP -0.189066289658318 7.18727306857422e-05 NA NA NA hsa-miR-589-3p FGF2 1.01962606923682 0.00577853347252709 -1.87861117290298 0.000125445679104344 mirMAP -0.306084948128741 0.00129523811230291 NA NA NA hsa-miR-590-3p FGF2 1.11654983899947 0.000160782154924864 -1.87861117290298 0.000125445679104344 miRanda;mirMAP -0.502156114781839 1.81367444334514e-05 NA NA NA hsa-miR-590-5p FGF2 1.04171442093217 0.000272475544954865 -1.87861117290298 0.000125445679104344 miRanda;mirMAP -0.698076507895779 4.36148419548274e-09 NA NA NA hsa-miR-92a-3p FGF2 1.2209325870225 6.8757197708107e-06 -1.87861117290298 0.000125445679104344 miRNAWalker2_validate -0.711959382156384 1.14570619492506e-08 NA NA NA hsa-miR-93-3p FGF2 1.88964231421793 1.80075645722786e-08 -1.87861117290298 0.000125445679104344 mirMAP -0.494286067593777 7.56548629194091e-07 NA NA NA hsa-miR-126-5p FGF5 0.41765430251855 0.0753161203651532 -0.112737413770707 0.889018159422693 mirMAP -1.27299674044633 1.36904003609118e-07 NA NA NA hsa-miR-15b-5p FGF5 1.62046407540723 5.42152621571078e-09 -0.112737413770707 0.889018159422693 miRNAWalker2_validate -0.628499833905292 0.00163763954361993 NA NA NA hsa-miR-16-1-3p FGF5 1.43227522002564 3.70920454953168e-08 -0.112737413770707 0.889018159422693 mirMAP -0.598397522653231 0.00540255809360042 NA NA NA hsa-miR-30b-5p FGF5 -0.430720743745757 0.0593564057320791 -0.112737413770707 0.889018159422693 mirMAP -1.09663962120345 1.27869374681852e-05 NA NA NA hsa-miR-30d-5p FGF5 -0.5492586056147 0.0140125082460125 -0.112737413770707 0.889018159422693 mirMAP -1.26603557046881 6.44034616744386e-07 NA NA NA hsa-miR-32-3p FGF5 0.583525764322974 0.11837203008551 -0.112737413770707 0.889018159422693 mirMAP -0.718233961496998 2.69211257467585e-05 NA NA NA hsa-miR-335-3p FGF5 2.5197689063267 2.20084506976733e-09 -0.112737413770707 0.889018159422693 mirMAP -0.482052236534025 0.00020013696125674 NA NA NA hsa-miR-338-3p FGF5 -0.959276231066179 0.0191473351014091 -0.112737413770707 0.889018159422693 miRanda -0.6177985816089 6.96794360953983e-06 NA NA NA hsa-miR-33a-3p FGF5 0.347011402017138 0.321709379745392 -0.112737413770707 0.889018159422693 mirMAP -0.576535909647833 0.000837306247871141 NA NA NA hsa-miR-500a-5p FGF5 0.00337014556047865 0.992120109131868 -0.112737413770707 0.889018159422693 mirMAP -0.614477528187278 0.000256513680663112 NA NA NA hsa-miR-501-5p FGF5 0.266919328110625 0.454779001968586 -0.112737413770707 0.889018159422693 PITA;mirMAP -0.62614984876482 9.06674208094652e-05 NA NA NA hsa-miR-577 FGF5 0.911619788986754 0.2256062124148 -0.112737413770707 0.889018159422693 miRNATAP -0.444405147807268 3.59000876753453e-09 NA NA NA hsa-miR-590-3p FGF5 1.11654983899947 0.000160782154924864 -0.112737413770707 0.889018159422693 miRanda;mirMAP;miRNATAP -0.612555222447379 0.00140100895653425 NA NA NA hsa-miR-7-1-3p FGF5 0.709309110750947 0.0412301737463194 -0.112737413770707 0.889018159422693 mirMAP -0.869207993564472 6.50749322750585e-08 NA NA NA hsa-let-7a-3p FGF7 0.503048155002889 0.0411145454335299 -1.5602156825587 0.00498637377963977 MirTarget;miRNATAP -0.731037360749972 5.50569814204452e-06 NA NA NA hsa-let-7b-3p FGF7 0.21838629112113 0.296038413622566 -1.5602156825587 0.00498637377963977 MirTarget;miRNATAP -0.741810215119105 0.000124390628283528 NA NA NA hsa-let-7f-1-3p FGF7 1.28704406797397 1.17954701106157e-06 -1.5602156825587 0.00498637377963977 MirTarget -0.619496528449976 2.19591491777331e-05 NA NA NA hsa-miR-107 FGF7 0.904627575346218 4.67936495073904e-05 -1.5602156825587 0.00498637377963977 PITA;miRanda;miRNATAP -0.777246028518609 1.06521367448641e-05 NA NA NA hsa-miR-15a-5p FGF7 1.03783090449383 7.40334108980898e-07 -1.5602156825587 0.00498637377963977 miRTarBase;miRNATAP -1.03381303077926 1.53980295049369e-08 NA NA NA hsa-miR-15b-5p FGF7 1.62046407540723 5.42152621571078e-09 -1.5602156825587 0.00498637377963977 miRNATAP -1.10853915197794 3.91159333945632e-18 NA NA NA hsa-miR-16-1-3p FGF7 1.43227522002564 3.70920454953168e-08 -1.5602156825587 0.00498637377963977 mirMAP -0.828766285961256 1.00941095464602e-08 NA NA NA hsa-miR-16-2-3p FGF7 1.8048179609245 2.83095715136409e-09 -1.5602156825587 0.00498637377963977 mirMAP -0.894500676245952 5.67629159494697e-14 NA NA NA hsa-miR-16-5p FGF7 1.00515772948091 5.33912942007619e-06 -1.5602156825587 0.00498637377963977 miRNATAP -1.4084082340258 1.61565851852723e-17 NA NA NA hsa-miR-18a-3p FGF7 2.35188582849667 1.39401350286321e-08 -1.5602156825587 0.00498637377963977 MirTarget -0.60538245987518 7.27850574065591e-12 NA NA NA hsa-miR-20a-5p FGF7 1.4503375861709 5.7813456424762e-07 -1.5602156825587 0.00498637377963977 miRNAWalker2_validate -0.815425734145646 2.61657869983007e-10 NA NA NA hsa-miR-26b-5p FGF7 -0.301646326928219 0.160081421968103 -1.5602156825587 0.00498637377963977 mirMAP -0.573628684843975 0.0024027834337405 NA NA NA hsa-miR-27a-3p FGF7 1.29886998470345 2.68986118553486e-08 -1.5602156825587 0.00498637377963977 MirTarget -0.784712509256695 1.6375276114047e-06 NA NA NA hsa-miR-31-5p FGF7 0.666358292391859 0.381800494600846 -1.5602156825587 0.00498637377963977 MirTarget -0.286141542958258 9.31592868791215e-08 NA NA NA hsa-miR-320a FGF7 0.593888711838028 0.011897419390526 -1.5602156825587 0.00498637377963977 miRanda -0.501509634690982 0.00321500749912934 NA NA NA hsa-miR-320b FGF7 1.11183660885284 0.000497971211648503 -1.5602156825587 0.00498637377963977 miRanda -0.602963126908309 6.53118857584566e-07 NA NA NA hsa-miR-33a-3p FGF7 0.347011402017138 0.321709379745392 -1.5602156825587 0.00498637377963977 mirMAP -0.714323468107036 6.96759113987999e-10 NA NA NA hsa-miR-361-5p FGF7 0.407725414130987 0.0181260969156347 -1.5602156825587 0.00498637377963977 PITA;miRanda;miRNATAP -1.05023708199515 7.33408072452573e-06 NA NA NA hsa-miR-3662 FGF7 1.82780708047676 0.0054036501346178 -1.5602156825587 0.00498637377963977 MirTarget;mirMAP;miRNATAP -0.343246402685412 7.47671778480477e-06 NA NA NA hsa-miR-421 FGF7 1.80720854070385 1.59709651202848e-07 -1.5602156825587 0.00498637377963977 miRanda -0.472997333251649 1.97004361691138e-05 NA NA NA hsa-miR-424-5p FGF7 1.08509868581983 0.000420473853818268 -1.5602156825587 0.00498637377963977 miRNATAP -0.685297094218223 4.20996402527186e-08 NA NA NA hsa-miR-429 FGF7 1.40182602301928 0.00900426780286475 -1.5602156825587 0.00498637377963977 miRNATAP -0.402624994165276 1.7337446619432e-08 NA NA NA hsa-miR-452-5p FGF7 2.08756506185889 0.000258095769002813 -1.5602156825587 0.00498637377963977 mirMAP -0.269324797275113 7.28201796410245e-05 NA NA NA hsa-miR-455-3p FGF7 2.29532323519288 1.85675588946527e-07 -1.5602156825587 0.00498637377963977 PITA;miRNATAP -0.699538843370974 3.81324365803807e-18 NA NA NA hsa-miR-484 FGF7 0.71327898984355 0.00233605130771196 -1.5602156825587 0.00498637377963977 PITA -0.917837472299362 3.34732094641496e-08 NA NA NA hsa-miR-486-5p FGF7 -0.627607241830911 0.155274583521138 -1.5602156825587 0.00498637377963977 MirTarget;miRanda -0.269041213010616 0.00282702512889706 NA NA NA hsa-miR-542-3p FGF7 0.757649022262991 0.00210575463285599 -1.5602156825587 0.00498637377963977 miRanda -0.575428372905158 0.000361082468087173 NA NA NA hsa-miR-577 FGF7 0.911619788986754 0.2256062124148 -1.5602156825587 0.00498637377963977 PITA;mirMAP -0.260587392511629 8.78612250385762e-07 NA NA NA hsa-miR-582-3p FGF7 -0.412897415951272 0.202939245403793 -1.5602156825587 0.00498637377963977 PITA;miRNATAP -0.478173140136422 9.36091921722173e-05 NA NA NA hsa-miR-590-3p FGF7 1.11654983899947 0.000160782154924864 -1.5602156825587 0.00498637377963977 PITA;miRanda;mirMAP;miRNATAP -0.672431604720525 2.51151561650779e-07 NA NA NA hsa-miR-590-5p FGF7 1.04171442093217 0.000272475544954865 -1.5602156825587 0.00498637377963977 PITA;miRanda -0.997192552428985 1.50828670699697e-14 NA NA NA hsa-miR-616-5p FGF7 0.834052908652744 0.0347835664029363 -1.5602156825587 0.00498637377963977 mirMAP -0.499565899304345 6.56838525058638e-07 NA NA NA hsa-miR-7-1-3p FGF7 0.709309110750947 0.0412301737463194 -1.5602156825587 0.00498637377963977 mirMAP -0.445680137233784 8.82810683468222e-05 NA NA NA hsa-miR-944 FGF7 3.33123095809751 0.0177835044930391 -1.5602156825587 0.00498637377963977 mirMAP -0.136791859053773 3.4948596692363e-05 NA NA NA hsa-miR-16-2-3p FGF9 1.8048179609245 2.83095715136409e-09 -1.74987286650449 0.0113341158170243 mirMAP -0.451752198937279 0.00402672168929665 NA NA NA hsa-miR-205-5p FGF9 3.13520672931882 0.0293226471971167 -1.74987286650449 0.0113341158170243 miRNATAP -0.152174402639521 6.027271820105e-06 NA NA NA hsa-miR-369-3p FGF9 0.32261175629684 0.3589927609891 -1.74987286650449 0.0113341158170243 mirMAP;miRNATAP -0.386601318549715 0.00627732180260434 NA NA NA hsa-miR-455-5p FGF9 1.20462751989145 6.74386011867484e-05 -1.74987286650449 0.0113341158170243 miRanda -0.615588799082101 0.000125067222771029 NA NA NA hsa-miR-944 FGF9 3.33123095809751 0.0177835044930391 -1.74987286650449 0.0113341158170243 mirMAP -0.169847944100435 3.49963470746257e-05 NA NA NA hsa-miR-106b-5p FGFR1 1.70863907461894 2.04074794107142e-08 -1.49877035356464 0.000511032592490219 mirMAP -0.289574146617841 0.00338081665085451 NA NA NA hsa-miR-135b-5p FGFR1 4.09156383496059 1.32294295002438e-12 -1.49877035356464 0.000511032592490219 mirMAP -0.239971522992425 1.30604624157818e-06 NA NA NA hsa-miR-15a-5p FGFR1 1.03783090449383 7.40334108980898e-07 -1.49877035356464 0.000511032592490219 miRNATAP -0.614121259747611 2.31269640677994e-05 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-5p FGFR1 1.62046407540723 5.42152621571078e-09 -1.49877035356464 0.000511032592490219 miRNATAP -0.428887511985041 6.35940222533532e-05 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-5p FGFR1 1.00515772948091 5.33912942007619e-06 -1.49877035356464 0.000511032592490219 miRTarBase;miRNATAP -0.646816679192102 2.46444393209917e-06 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-17-5p FGFR1 1.65862087862483 8.45603406215941e-08 -1.49877035356464 0.000511032592490219 mirMAP -0.385666132191953 6.54751310730238e-05 NA NA NA hsa-miR-200a-5p FGFR1 1.50371809098978 0.00263602434344863 -1.49877035356464 0.000511032592490219 mirMAP -0.353457026193588 2.65731844551453e-09 NA NA NA hsa-miR-200b-5p FGFR1 0.969871521250413 0.0530500454130183 -1.49877035356464 0.000511032592490219 mirMAP -0.379845880120484 1.1792923473536e-09 NA NA NA hsa-miR-20a-5p FGFR1 1.4503375861709 5.7813456424762e-07 -1.49877035356464 0.000511032592490219 mirMAP -0.375915424325503 0.00030587275135307 NA NA NA hsa-miR-330-3p FGFR1 0.798460296022179 0.00746538156533435 -1.49877035356464 0.000511032592490219 PITA;miRNATAP -0.282998543312954 0.00663632549076157 NA NA NA hsa-miR-330-5p FGFR1 0.488365986827708 0.0512207630808233 -1.49877035356464 0.000511032592490219 miRanda;miRNATAP -0.46885020733595 0.000163163733168213 NA NA NA hsa-miR-335-3p FGFR1 2.5197689063267 2.20084506976733e-09 -1.49877035356464 0.000511032592490219 mirMAP -0.292645618532702 2.80734523112232e-05 NA NA NA hsa-miR-532-5p FGFR1 0.313080805824184 0.252248939356301 -1.49877035356464 0.000511032592490219 PITA -0.412833293773713 0.000296657475622566 NA NA NA hsa-miR-577 FGFR1 0.911619788986754 0.2256062124148 -1.49877035356464 0.000511032592490219 PITA;mirMAP -0.163290896258138 9.38787002002887e-05 NA NA NA hsa-miR-186-5p FGFR2 0.149964130725901 0.434709542998771 -0.0989978709215018 0.814042278338263 miRNAWalker2_validate -0.416290327670683 0.00939242147576651 NA NA NA hsa-miR-326 FGFR2 -0.429748586406214 0.2629894124021 -0.0989978709215018 0.814042278338263 miRanda -0.227787287684123 0.00384928442941226 NA NA NA hsa-miR-338-3p FGFR2 -0.959276231066179 0.0191473351014091 -0.0989978709215018 0.814042278338263 miRanda;miRNATAP -0.196178980077981 0.00698122481372059 NA NA NA hsa-miR-194-5p FGFR3 -0.127742909829168 0.906065815804667 1.65518678016625 0.0043355270123643 miRNATAP -0.225086870713638 1.12067768221423e-09 NA NA NA hsa-miR-532-5p FGFR3 0.313080805824184 0.252248939356301 1.65518678016625 0.0043355270123643 mirMAP -0.433951889263385 0.0047914041475262 NA NA NA hsa-miR-100-5p FLT1 -0.909635282943505 0.0262703445792608 -0.305628570833107 0.338279360820836 miRNAWalker2_validate;miRTarBase -0.144645999080795 0.00881472847765584 NA NA NA hsa-miR-149-5p FLT1 0.706277554734069 0.296848731347677 -0.305628570833107 0.338279360820836 MirTarget -0.184807386146691 1.08019816320546e-08 NA NA NA hsa-miR-224-5p FLT1 2.7648036144402 0.000111736336240167 -0.305628570833107 0.338279360820836 mirMAP -0.114667969204663 0.000193997297726446 NA NA NA hsa-miR-24-3p FLT1 1.08578167539644 6.18549359075268e-07 -0.305628570833107 0.338279360820836 miRNATAP -0.3879085895128 0.000142028146197539 NA NA NA hsa-miR-708-5p FLT1 1.41830449251856 0.0109647946476309 -0.305628570833107 0.338279360820836 MirTarget -0.149095875231464 0.000191499476944778 NA NA NA hsa-miR-744-3p FLT1 1.40439584998788 0.000973603203532439 -0.305628570833107 0.338279360820836 MirTarget -0.158837536398904 0.00255291103967256 NA NA NA hsa-miR-944 FLT1 3.33123095809751 0.0177835044930391 -0.305628570833107 0.338279360820836 mirMAP;miRNATAP -0.103734422607415 1.83664150134639e-08 NA NA NA hsa-miR-1271-5p FOXO4 1.15538250415776 0.00207865862606828 -0.823671872776551 0.000805577693438195 MirTarget -0.247770722934928 7.3099389484308e-08 NA NA NA hsa-miR-149-5p FOXO4 0.706277554734069 0.296848731347677 -0.823671872776551 0.000805577693438195 MirTarget -0.148235485175999 3.54351993344567e-09 NA NA NA hsa-miR-193a-3p FOXO4 0.214911823818578 0.399323056245552 -0.823671872776551 0.000805577693438195 miRanda;miRNATAP -0.22741721786711 0.00113643727765158 NA NA NA hsa-miR-214-3p FOXO4 1.01201534142544 0.00625092909225755 -0.823671872776551 0.000805577693438195 MirTarget -0.171897474559373 0.000262639282480546 NA NA NA hsa-miR-2355-5p FOXO4 0.594869787574182 0.120591076715177 -0.823671872776551 0.000805577693438195 MirTarget -0.302088310271666 5.44393154913585e-12 NA NA NA hsa-miR-23a-3p FOXO4 1.10685926969665 3.16223452471768e-08 -0.823671872776551 0.000805577693438195 miRNATAP -0.457522775943062 6.32297744626029e-08 NA NA NA hsa-miR-34c-5p FOXO4 2.20632574870337 0.000379662996168678 -0.823671872776551 0.000805577693438195 miRanda -0.140990920753927 2.96475879350669e-07 NA NA NA hsa-miR-484 FOXO4 0.71327898984355 0.00233605130771196 -0.823671872776551 0.000805577693438195 miRNATAP -0.296069465519636 7.83022697393236e-05 NA NA NA hsa-miR-590-5p FOXO4 1.04171442093217 0.000272475544954865 -0.823671872776551 0.000805577693438195 miRanda -0.233268645465609 0.000121590347290886 NA NA NA hsa-miR-940 FOXO4 1.64406174271686 0.000690854900107004 -0.823671872776551 0.000805577693438195 MirTarget;miRNATAP -0.16274703204287 0.00011236340921751 NA NA NA hsa-miR-96-5p FOXO4 1.14243043653372 0.00942969392739105 -0.823671872776551 0.000805577693438195 MirTarget;TargetScan;miRNATAP -0.128541507484601 0.00205717967749568 NA NA NA hsa-let-7a-3p GAB1 0.503048155002889 0.0411145454335299 -0.958287947114483 0.000187943856635889 mirMAP -0.203017447465162 0.00748082845461267 NA NA NA hsa-let-7f-1-3p GAB1 1.28704406797397 1.17954701106157e-06 -0.958287947114483 0.000187943856635889 mirMAP -0.323674381723762 1.48759813473929e-06 NA NA NA hsa-miR-106b-5p GAB1 1.70863907461894 2.04074794107142e-08 -0.958287947114483 0.000187943856635889 MirTarget;miRNATAP -0.27014992860925 2.90861808840612e-06 NA NA NA hsa-miR-141-3p GAB1 1.45548825076434 0.00115958850961764 -0.958287947114483 0.000187943856635889 MirTarget;TargetScan -0.126122510302757 0.00194260819047124 NA NA NA hsa-miR-141-5p GAB1 2.07543489990205 6.42575039070838e-06 -0.958287947114483 0.000187943856635889 MirTarget -0.126917289515239 0.00116862580264791 NA NA NA hsa-miR-142-3p GAB1 1.32364054836498 0.0001537753622128 -0.958287947114483 0.000187943856635889 MirTarget;PITA;miRanda;miRNATAP -0.142265552933236 0.00645307880977987 NA NA NA hsa-miR-15b-3p GAB1 1.75738933306437 3.00554466232543e-08 -0.958287947114483 0.000187943856635889 mirMAP -0.236667283838814 2.19006021407973e-05 NA NA NA hsa-miR-16-1-3p GAB1 1.43227522002564 3.70920454953168e-08 -0.958287947114483 0.000187943856635889 mirMAP -0.192572163897022 0.00543551718248502 NA NA NA hsa-miR-17-5p GAB1 1.65862087862483 8.45603406215941e-08 -0.958287947114483 0.000187943856635889 MirTarget;TargetScan;miRNATAP -0.197267517452638 0.00063724415238029 NA NA NA hsa-miR-186-5p GAB1 0.149964130725901 0.434709542998771 -0.958287947114483 0.000187943856635889 mirMAP -0.300440175641002 0.00237585432517459 NA NA NA hsa-miR-18a-5p GAB1 2.20211504140984 1.78678887916334e-09 -0.958287947114483 0.000187943856635889 MirTarget;miRNATAP -0.203541667821234 2.09756458604625e-05 NA NA NA hsa-miR-200a-3p GAB1 0.717826667295984 0.193912116506827 -0.958287947114483 0.000187943856635889 MirTarget -0.113223432781845 0.000654190000878503 NA NA NA hsa-miR-200b-3p GAB1 0.974577911407732 0.0595020056914543 -0.958287947114483 0.000187943856635889 TargetScan -0.122123652357029 0.000564693707081838 NA NA NA hsa-miR-20a-5p GAB1 1.4503375861709 5.7813456424762e-07 -0.958287947114483 0.000187943856635889 MirTarget;miRNATAP -0.181044265273191 0.00365068741613954 NA NA NA hsa-miR-212-3p GAB1 0.960352937108106 0.00133449812322732 -0.958287947114483 0.000187943856635889 mirMAP -0.239751748148333 8.68619061593178e-05 NA NA NA hsa-miR-221-3p GAB1 1.33496247538338 3.82022531235275e-07 -0.958287947114483 0.000187943856635889 MirTarget;miRNATAP -0.303183366237221 7.9038618557321e-06 NA NA NA hsa-miR-222-3p GAB1 1.39382731585819 9.98182478024671e-07 -0.958287947114483 0.000187943856635889 MirTarget;miRNATAP -0.29640229034901 2.0378677809229e-06 NA NA NA hsa-miR-29b-1-5p GAB1 0.606560155953522 0.116355599574769 -0.958287947114483 0.000187943856635889 mirMAP -0.214047359966723 5.91042194777221e-06 NA NA NA hsa-miR-330-3p GAB1 0.798460296022179 0.00746538156533435 -0.958287947114483 0.000187943856635889 PITA;mirMAP;miRNATAP -0.19094455648035 0.00200954165978782 NA NA NA hsa-miR-335-3p GAB1 2.5197689063267 2.20084506976733e-09 -0.958287947114483 0.000187943856635889 mirMAP -0.186455919065569 6.67728984531874e-06 NA NA NA hsa-miR-34a-5p GAB1 0.794251341270032 0.00024017386701179 -0.958287947114483 0.000187943856635889 MirTarget -0.253978006916422 0.00304699618993026 NA NA NA hsa-miR-429 GAB1 1.40182602301928 0.00900426780286475 -0.958287947114483 0.000187943856635889 miRanda;miRNATAP -0.144927000317373 1.69366141965073e-05 NA NA NA hsa-miR-590-3p GAB1 1.11654983899947 0.000160782154924864 -0.958287947114483 0.000187943856635889 miRanda;mirMAP -0.227082459057335 0.000221119090757467 NA NA NA hsa-miR-7-1-3p GAB1 0.709309110750947 0.0412301737463194 -0.958287947114483 0.000187943856635889 mirMAP -0.170760241272188 0.00128904444167456 NA NA NA hsa-miR-93-5p GAB1 1.7515174434778 1.59386482413883e-08 -0.958287947114483 0.000187943856635889 MirTarget;miRNATAP -0.190779696525014 0.000909101454845913 NA NA NA hsa-let-7b-5p GAB2 0.0582902155815681 0.781400138984745 -1.24196600792341 0.000134264378716295 MirTarget -0.553359284678791 7.91354419780384e-07 NA NA NA hsa-let-7d-5p GAB2 0.981733854788227 7.26366577706469e-07 -1.24196600792341 0.000134264378716295 MirTarget -0.357937450081492 0.00234796100586153 NA NA NA hsa-let-7i-5p GAB2 0.798954594465461 2.99735653959449e-05 -1.24196600792341 0.000134264378716295 MirTarget -0.429467821480205 0.000466915622556385 NA NA NA hsa-miR-1301-3p GAB2 1.59017279464031 4.6624715470094e-06 -1.24196600792341 0.000134264378716295 MirTarget -0.269266459283828 3.9256629207269e-05 NA NA NA hsa-miR-130b-5p GAB2 0.701350393759937 0.0510142718395002 -1.24196600792341 0.000134264378716295 mirMAP -0.256691335477307 7.31348637583698e-05 NA NA NA hsa-miR-134-5p GAB2 0.565477776815981 0.109621868298098 -1.24196600792341 0.000134264378716295 MirTarget -0.314795316144426 1.43876348461023e-06 NA NA NA hsa-miR-181a-5p GAB2 1.39227281909646 1.91689469974826e-09 -1.24196600792341 0.000134264378716295 mirMAP -0.326892657205875 0.000856878527853181 NA NA NA hsa-miR-181b-5p GAB2 1.64216500592669 1.89228845300725e-08 -1.24196600792341 0.000134264378716295 mirMAP -0.259171326485359 0.000847722086621354 NA NA NA hsa-miR-185-3p GAB2 1.33711019171256 3.45756583967985e-05 -1.24196600792341 0.000134264378716295 MirTarget -0.211640741308856 0.00312641258578549 NA NA NA hsa-miR-18a-3p GAB2 2.35188582849667 1.39401350286321e-08 -1.24196600792341 0.000134264378716295 MirTarget -0.157365617926385 0.0040044738423284 NA NA NA hsa-miR-18a-5p GAB2 2.20211504140984 1.78678887916334e-09 -1.24196600792341 0.000134264378716295 miRNATAP -0.160727977102802 0.00917320328084192 NA NA NA hsa-miR-214-3p GAB2 1.01201534142544 0.00625092909225755 -1.24196600792341 0.000134264378716295 mirMAP -0.216550960333909 0.000568423756047166 NA NA NA hsa-miR-2355-3p GAB2 0.982963823342009 0.0229275810851348 -1.24196600792341 0.000134264378716295 miRNATAP -0.293116718491364 4.25617645310887e-08 NA NA NA hsa-miR-296-5p GAB2 0.932146077883618 0.0602370559607489 -1.24196600792341 0.000134264378716295 MirTarget -0.258156224433905 7.04002644979671e-08 NA NA NA hsa-miR-452-3p GAB2 2.2028815467959 0.00185370432491004 -1.24196600792341 0.000134264378716295 mirMAP -0.279567529345425 4.23090588788279e-16 NA NA NA hsa-miR-589-3p GAB2 1.01962606923682 0.00577853347252709 -1.24196600792341 0.000134264378716295 mirMAP -0.19692074910258 0.00180984136894358 NA NA NA hsa-miR-629-3p GAB2 1.40326397107309 9.7803063526732e-05 -1.24196600792341 0.000134264378716295 mirMAP -0.245127930702313 0.000119866678817769 NA NA NA hsa-miR-93-3p GAB2 1.88964231421793 1.80075645722786e-08 -1.24196600792341 0.000134264378716295 mirMAP -0.369066606462226 1.88638859877903e-08 NA NA NA hsa-miR-940 GAB2 1.64406174271686 0.000690854900107004 -1.24196600792341 0.000134264378716295 mirMAP -0.274122874249673 7.6112478654192e-07 NA NA NA hsa-miR-126-5p GNB4 0.41765430251855 0.0753161203651532 -0.21175622394543 0.603353968429849 mirMAP -0.529774519793596 1.70510513243194e-05 NA NA NA hsa-miR-140-3p GNB4 -0.296251775392129 0.127539826012144 -0.21175622394543 0.603353968429849 MirTarget -0.516692025368155 0.00066721631620101 NA NA NA hsa-miR-186-5p GNB4 0.149964130725901 0.434709542998771 -0.21175622394543 0.603353968429849 MirTarget -0.563819737170919 0.000248498907464407 NA NA NA hsa-miR-29a-3p GNB4 -0.113012156986374 0.615005009685815 -0.21175622394543 0.603353968429849 MirTarget -0.578856677853384 7.51132369936815e-06 NA NA NA hsa-miR-29b-3p GNB4 -0.230693226193598 0.367461626035234 -0.21175622394543 0.603353968429849 MirTarget -0.455506558775273 5.82003804275857e-05 NA NA NA hsa-miR-338-5p GNB4 -1.19659203838734 0.0100316010080496 -0.21175622394543 0.603353968429849 MirTarget -0.313084311693515 2.10801705551083e-07 NA NA NA hsa-miR-33a-3p GNB4 0.347011402017138 0.321709379745392 -0.21175622394543 0.603353968429849 MirTarget -0.364023079603871 2.43469227065651e-05 NA NA NA hsa-miR-429 GNB4 1.40182602301928 0.00900426780286475 -0.21175622394543 0.603353968429849 miRanda -0.400573709437329 8.14257043622777e-16 NA NA NA hsa-miR-501-5p GNB4 0.266919328110625 0.454779001968586 -0.21175622394543 0.603353968429849 mirMAP -0.461980343448947 4.30475885649682e-09 NA NA NA hsa-miR-7-1-3p GNB4 0.709309110750947 0.0412301737463194 -0.21175622394543 0.603353968429849 MirTarget -0.601976307796118 1.22640253683285e-14 NA NA NA hsa-miR-877-5p GNB4 2.17859965442336 1.03593450648516e-07 -0.21175622394543 0.603353968429849 MirTarget -0.298680776737718 9.19722992507621e-06 NA NA NA hsa-miR-130b-3p GNB5 1.32714007211004 4.78676252285191e-05 0.00752956764213852 0.971809729265749 miRNAWalker2_validate -0.135578490630467 0.00281883585116708 NA NA NA hsa-miR-148a-3p GNB5 -1.53721533763578 3.55533747293117e-05 0.00752956764213852 0.971809729265749 miRNAWalker2_validate -0.17677274524096 6.30743874451622e-06 NA NA NA hsa-miR-17-5p GNB5 1.65862087862483 8.45603406215941e-08 0.00752956764213852 0.971809729265749 TargetScan -0.128854045850957 0.00641088433761162 NA NA NA hsa-miR-338-3p GNB5 -0.959276231066179 0.0191473351014091 0.00752956764213852 0.971809729265749 miRanda -0.155423052296047 1.67068797514615e-05 NA NA NA hsa-miR-425-5p GNB5 1.13924952403101 0.000255357546232931 0.00752956764213852 0.971809729265749 miRNAWalker2_validate -0.176400814019148 0.000204502477491449 NA NA NA hsa-miR-429 GNB5 1.40182602301928 0.00900426780286475 0.00752956764213852 0.971809729265749 miRanda -0.151368187892592 1.9962881452872e-08 NA NA NA hsa-miR-107 GNG12 0.904627575346218 4.67936495073904e-05 -0.294101873698593 0.112771340553714 miRanda -0.200412767237989 0.000630268384679819 NA NA NA hsa-miR-126-5p GNG12 0.41765430251855 0.0753161203651532 -0.294101873698593 0.112771340553714 mirMAP -0.156388609985589 0.0057405609112311 NA NA NA hsa-miR-140-5p GNG12 0.208193069681326 0.303002433893804 -0.294101873698593 0.112771340553714 PITA;miRanda -0.252822882443761 0.000124004811884371 NA NA NA hsa-miR-374b-5p GNG12 -0.188120735251554 0.394800117237392 -0.294101873698593 0.112771340553714 mirMAP -0.174991830772569 0.00379237778781347 NA NA NA hsa-miR-423-5p GNG12 0.832613878736338 0.000791321227103338 -0.294101873698593 0.112771340553714 miRNAWalker2_validate -0.240235936972391 3.80058099265444e-06 NA NA NA hsa-miR-590-3p GNG12 1.11654983899947 0.000160782154924864 -0.294101873698593 0.112771340553714 miRanda;mirMAP -0.121726190652431 0.00559991009386133 NA NA NA hsa-miR-590-5p GNG12 1.04171442093217 0.000272475544954865 -0.294101873698593 0.112771340553714 PITA -0.130764537784798 0.00404814498177005 NA NA NA hsa-miR-23a-3p GNG2 1.10685926969665 3.16223452471768e-08 -0.36392009320106 0.264619871146767 miRNATAP -0.391321108423012 0.000567944429330178 NA NA NA hsa-miR-23b-3p GNG2 -0.286465516491361 0.18664668472995 -0.36392009320106 0.264619871146767 miRNATAP -0.320627669163308 0.00319374792190231 NA NA NA hsa-miR-3065-5p GNG2 -0.241623656423063 0.633116553078159 -0.36392009320106 0.264619871146767 mirMAP;miRNATAP -0.165149640492123 0.000400398874848712 NA NA NA hsa-miR-335-3p GNG2 2.5197689063267 2.20084506976733e-09 -0.36392009320106 0.264619871146767 mirMAP -0.140220705544017 0.00786726203377881 NA NA NA hsa-miR-429 GNG2 1.40182602301928 0.00900426780286475 -0.36392009320106 0.264619871146767 miRanda;miRNATAP -0.192009989118279 5.05976261984203e-06 NA NA NA hsa-miR-576-5p GNG2 0.625714137488957 0.0417100301848969 -0.36392009320106 0.264619871146767 mirMAP -0.202102185689406 0.00759361179797321 NA NA NA hsa-miR-590-5p GNG2 1.04171442093217 0.000272475544954865 -0.36392009320106 0.264619871146767 miRanda;miRNATAP -0.274301295213188 0.00060722336088799 NA NA NA hsa-miR-192-3p GNG4 0.355565421687399 0.74117031340037 -0.292817690722517 0.752274685320027 MirTarget -0.364674344868212 1.07019665834202e-09 NA NA NA hsa-miR-200a-3p GNG4 0.717826667295984 0.193912116506827 -0.292817690722517 0.752274685320027 mirMAP -0.438810884002929 0.000204120579501834 NA NA NA hsa-miR-200b-3p GNG4 0.974577911407732 0.0595020056914543 -0.292817690722517 0.752274685320027 mirMAP -0.438818774747985 0.000511420878206377 NA NA NA hsa-miR-338-3p GNG4 -0.959276231066179 0.0191473351014091 -0.292817690722517 0.752274685320027 miRanda -0.796032251990307 3.80708496561738e-07 NA NA NA hsa-miR-429 GNG4 1.40182602301928 0.00900426780286475 -0.292817690722517 0.752274685320027 mirMAP -0.390110601035772 0.00131414397722242 NA NA NA hsa-miR-199a-5p GNG5 0.371973504507027 0.232661597228763 0.0760959044090024 0.667214339294949 MirTarget;miRanda;miRNATAP -0.225385306625696 7.21762479482505e-09 NA NA NA hsa-miR-199b-5p GNG5 0.124595928096068 0.678156859366405 0.0760959044090024 0.667214339294949 MirTarget;miRanda;miRNATAP -0.177376310657559 1.76689098459512e-05 NA NA NA hsa-miR-1254 GNG7 0.941374574140312 0.0605480748500796 -3.4565296709262 6.28535535483384e-12 miRNATAP -0.375539534022685 2.88003797639596e-05 NA NA NA hsa-miR-1271-5p GNG7 1.15538250415776 0.00207865862606828 -3.4565296709262 6.28535535483384e-12 mirMAP -0.263765152421519 0.00952810755390318 NA NA NA hsa-miR-141-3p GNG7 1.45548825076434 0.00115958850961764 -3.4565296709262 6.28535535483384e-12 MirTarget;TargetScan;miRNATAP -0.495816263696205 7.26806862953206e-10 NA NA NA hsa-miR-17-3p GNG7 1.31126744284937 3.24768335024185e-07 -3.4565296709262 6.28535535483384e-12 mirMAP -0.779599286745246 2.95691362969474e-08 NA NA NA hsa-miR-182-5p GNG7 0.887369486030646 0.0310640781418789 -3.4565296709262 6.28535535483384e-12 mirMAP -0.488173315809994 4.5612941659672e-08 NA NA NA hsa-miR-185-3p GNG7 1.33711019171256 3.45756583967985e-05 -3.4565296709262 6.28535535483384e-12 mirMAP -0.666905647454356 2.33102713290999e-09 NA NA NA hsa-miR-18a-3p GNG7 2.35188582849667 1.39401350286321e-08 -3.4565296709262 6.28535535483384e-12 mirMAP -0.578103482263822 5.74785706512557e-12 NA NA NA hsa-miR-18a-5p GNG7 2.20211504140984 1.78678887916334e-09 -3.4565296709262 6.28535535483384e-12 mirMAP -0.609594609776221 1.58838071424393e-10 NA NA NA hsa-miR-193b-5p GNG7 0.609581100028941 0.13923921336815 -3.4565296709262 6.28535535483384e-12 mirMAP -0.502340798433604 1.78569939058345e-08 NA NA NA hsa-miR-200a-3p GNG7 0.717826667295984 0.193912116506827 -3.4565296709262 6.28535535483384e-12 MirTarget;miRNATAP -0.201196903885862 0.00325418058864664 NA NA NA hsa-miR-22-5p GNG7 0.804348748654247 0.000804065112767412 -3.4565296709262 6.28535535483384e-12 mirMAP -0.416271323093906 0.00861328608320733 NA NA NA hsa-miR-224-5p GNG7 2.7648036144402 0.000111736336240167 -3.4565296709262 6.28535535483384e-12 mirMAP -0.241515148302505 2.1128035922729e-06 NA NA NA hsa-miR-23a-3p GNG7 1.10685926969665 3.16223452471768e-08 -3.4565296709262 6.28535535483384e-12 mirMAP -0.896968058742437 9.41743357621311e-07 NA NA NA hsa-miR-31-3p GNG7 0.474904754927656 0.506866261575484 -3.4565296709262 6.28535535483384e-12 mirMAP -0.181490167241839 0.000620089034431963 NA NA NA hsa-miR-31-5p GNG7 0.666358292391859 0.381800494600846 -3.4565296709262 6.28535535483384e-12 mirMAP -0.200242711547866 0.000112260834993831 NA NA NA hsa-miR-3127-5p GNG7 0.98677589413294 0.00734249049849 -3.4565296709262 6.28535535483384e-12 mirMAP -0.365501244326962 0.000345915539351558 NA NA NA hsa-miR-323b-3p GNG7 1.13581624461921 0.0214847831286342 -3.4565296709262 6.28535535483384e-12 mirMAP -0.344117888424896 5.54388473559741e-05 NA NA NA hsa-miR-3615 GNG7 1.25850728223629 0.000102643804657077 -3.4565296709262 6.28535535483384e-12 mirMAP -0.568688463012534 4.8714178174758e-07 NA NA NA hsa-miR-590-3p GNG7 1.11654983899947 0.000160782154924864 -3.4565296709262 6.28535535483384e-12 PITA;miRanda;mirMAP -0.363008965804527 0.00424025361252838 NA NA NA hsa-miR-616-5p GNG7 0.834052908652744 0.0347835664029363 -3.4565296709262 6.28535535483384e-12 MirTarget -0.312833515977665 0.00130027277417549 NA NA NA hsa-miR-671-5p GNG7 0.947458646379882 0.0024732430914236 -3.4565296709262 6.28535535483384e-12 mirMAP -0.519315073011342 1.25877563516228e-05 NA NA NA hsa-miR-92a-3p GNG7 1.2209325870225 6.8757197708107e-06 -3.4565296709262 6.28535535483384e-12 miRNAWalker2_validate -0.884545394720387 1.60756395882906e-11 NA NA NA hsa-miR-939-5p GNG7 0.857156740351386 0.0124815824643173 -3.4565296709262 6.28535535483384e-12 mirMAP -0.568213928667562 1.72583932749064e-06 NA NA NA hsa-miR-940 GNG7 1.64406174271686 0.000690854900107004 -3.4565296709262 6.28535535483384e-12 MirTarget -0.390314124027094 1.47397804630475e-05 NA NA NA hsa-miR-96-5p GNG7 1.14243043653372 0.00942969392739105 -3.4565296709262 6.28535535483384e-12 mirMAP -0.516933724306247 2.47250678001813e-09 NA NA NA hsa-miR-29a-5p GNGT1 0.585084040404152 0.023014129158495 2.97304746826854 0.00013849587261965 mirMAP -0.64293588134879 0.00360033672657742 NA NA NA hsa-miR-219a-1-3p GNGT2 1.25987698719907 0.000462608426981798 0.351965126193358 0.317137720452162 MirTarget -0.274844342976407 5.51276980599983e-05 NA NA NA hsa-miR-342-3p GRIN1 0.318119432680668 0.269150960124243 -0.836534363270022 0.108084236259274 PITA -0.429147899612962 0.000916818137716886 NA NA NA hsa-miR-342-5p GRIN1 0.692955062695486 0.030998736359949 -0.836534363270022 0.108084236259274 PITA;mirMAP;miRNATAP -0.391206740712317 0.000676079041533122 NA NA NA hsa-let-7a-3p GRIN2A 0.503048155002889 0.0411145454335299 -3.62031687507598 4.89793835876785e-06 mirMAP -0.673009706452652 0.00453546765023122 NA NA NA hsa-let-7b-3p GRIN2A 0.21838629112113 0.296038413622566 -3.62031687507598 4.89793835876785e-06 mirMAP -1.01296060228231 0.000312527665244912 NA NA NA hsa-let-7f-1-3p GRIN2A 1.28704406797397 1.17954701106157e-06 -3.62031687507598 4.89793835876785e-06 mirMAP -1.21870643982792 4.14133362889336e-09 NA NA NA hsa-miR-107 GRIN2A 0.904627575346218 4.67936495073904e-05 -3.62031687507598 4.89793835876785e-06 miRanda -0.810965507246282 0.00175429956101809 NA NA NA hsa-miR-1254 GRIN2A 0.941374574140312 0.0605480748500796 -3.62031687507598 4.89793835876785e-06 PITA -0.421800483405682 0.00230782598570162 NA NA NA hsa-miR-130b-5p GRIN2A 0.701350393759937 0.0510142718395002 -3.62031687507598 4.89793835876785e-06 mirMAP -0.655648858834308 3.74939782146982e-05 NA NA NA hsa-miR-148b-5p GRIN2A 1.04409494910362 0.00195860954157389 -3.62031687507598 4.89793835876785e-06 mirMAP -0.599612960257835 0.000402369395362398 NA NA NA hsa-miR-15b-3p GRIN2A 1.75738933306437 3.00554466232543e-08 -3.62031687507598 4.89793835876785e-06 mirMAP -1.02475591099379 1.81800515684533e-09 NA NA NA hsa-miR-182-5p GRIN2A 0.887369486030646 0.0310640781418789 -3.62031687507598 4.89793835876785e-06 mirMAP -0.750876164109626 3.45099979781336e-08 NA NA NA hsa-miR-200b-3p GRIN2A 0.974577911407732 0.0595020056914543 -3.62031687507598 4.89793835876785e-06 TargetScan -0.345287243847407 0.00188251792990492 NA NA NA hsa-miR-224-5p GRIN2A 2.7648036144402 0.000111736336240167 -3.62031687507598 4.89793835876785e-06 mirMAP -0.26636392776693 0.000723663102152984 NA NA NA hsa-miR-23a-3p GRIN2A 1.10685926969665 3.16223452471768e-08 -3.62031687507598 4.89793835876785e-06 mirMAP -1.02107192908473 0.000308620789325498 NA NA NA hsa-miR-25-3p GRIN2A 1.00604871526544 0.000421838061147906 -3.62031687507598 4.89793835876785e-06 mirMAP -0.609746160275426 0.00244187644901417 NA NA NA hsa-miR-32-3p GRIN2A 0.583525764322974 0.11837203008551 -3.62031687507598 4.89793835876785e-06 mirMAP -0.653966116331697 0.000157498179453851 NA NA NA hsa-miR-320b GRIN2A 1.11183660885284 0.000497971211648503 -3.62031687507598 4.89793835876785e-06 PITA -0.760323087602377 1.78506403388079e-05 NA NA NA hsa-miR-335-3p GRIN2A 2.5197689063267 2.20084506976733e-09 -3.62031687507598 4.89793835876785e-06 mirMAP -0.601248897348878 3.29446011943806e-06 NA NA NA hsa-miR-33a-3p GRIN2A 0.347011402017138 0.321709379745392 -3.62031687507598 4.89793835876785e-06 mirMAP -0.53782844706454 0.00202037615702488 NA NA NA hsa-miR-577 GRIN2A 0.911619788986754 0.2256062124148 -3.62031687507598 4.89793835876785e-06 PITA -0.302455919744464 0.000100426422958593 NA NA NA hsa-miR-582-5p GRIN2A -0.448820171762719 0.134615974001015 -3.62031687507598 4.89793835876785e-06 mirMAP -0.698017695444126 0.000291184923638805 NA NA NA hsa-miR-590-3p GRIN2A 1.11654983899947 0.000160782154924864 -3.62031687507598 4.89793835876785e-06 miRanda;mirMAP -0.963292298862457 3.6032847364396e-07 NA NA NA hsa-miR-590-5p GRIN2A 1.04171442093217 0.000272475544954865 -3.62031687507598 4.89793835876785e-06 miRanda -1.08235634944431 2.80872688243323e-08 NA NA NA hsa-miR-629-5p GRIN2A 1.06377074768516 0.000536624707722274 -3.62031687507598 4.89793835876785e-06 mirMAP -0.957462825235473 1.61066684797252e-07 NA NA NA hsa-miR-877-5p GRIN2A 2.17859965442336 1.03593450648516e-07 -3.62031687507598 4.89793835876785e-06 mirMAP -0.53670318148966 7.25641742900913e-05 NA NA NA hsa-miR-92a-3p GRIN2A 1.2209325870225 6.8757197708107e-06 -3.62031687507598 4.89793835876785e-06 mirMAP -1.32280027231657 4.42691669314505e-11 NA NA NA hsa-let-7a-3p HGF 0.503048155002889 0.0411145454335299 -0.376531570639447 0.550491511103826 mirMAP -0.818691872864681 6.02516795359655e-06 NA NA NA hsa-let-7b-3p HGF 0.21838629112113 0.296038413622566 -0.376531570639447 0.550491511103826 mirMAP -0.849666066489082 9.15421436976392e-05 NA NA NA hsa-miR-141-3p HGF 1.45548825076434 0.00115958850961764 -0.376531570639447 0.550491511103826 MirTarget;TargetScan -0.486507123512748 4.89226986811595e-07 NA NA NA hsa-miR-203a-3p HGF 1.44736908507496 0.0394116388736904 -0.376531570639447 0.550491511103826 MirTarget -0.518782559309176 3.06524300072984e-19 NA NA NA hsa-miR-224-3p HGF 1.52422171450716 0.00650463542340912 -0.376531570639447 0.550491511103826 mirMAP -0.463827973319244 4.02273153083653e-08 NA NA NA hsa-miR-33a-3p HGF 0.347011402017138 0.321709379745392 -0.376531570639447 0.550491511103826 mirMAP -0.544350013780391 4.75735535202373e-05 NA NA NA hsa-miR-34c-5p HGF 2.20632574870337 0.000379662996168678 -0.376531570639447 0.550491511103826 miRanda -0.305112726593846 1.53268570245237e-05 NA NA NA hsa-miR-3682-3p HGF 1.96838261925327 4.94885331227292e-06 -0.376531570639447 0.550491511103826 mirMAP -0.404404600221883 0.000774301762513964 NA NA NA hsa-miR-590-5p HGF 1.04171442093217 0.000272475544954865 -0.376531570639447 0.550491511103826 miRanda -0.577047667344204 0.000185605077930884 NA NA NA hsa-miR-944 HGF 3.33123095809751 0.0177835044930391 -0.376531570639447 0.550491511103826 mirMAP -0.251904679029854 1.61296788568438e-12 NA NA NA hsa-miR-29b-3p HTR7 -0.230693226193598 0.367461626035234 -0.17347953123616 0.83432775136575 miRNATAP -0.788044128241543 0.000690563795731559 NA NA NA hsa-miR-326 HTR7 -0.429748586406214 0.2629894124021 -0.17347953123616 0.83432775136575 miRanda;miRNATAP -0.827266496719262 4.54442031052667e-08 NA NA NA hsa-miR-335-5p HTR7 1.59953351087307 5.56170899867314e-05 -0.17347953123616 0.83432775136575 miRNAWalker2_validate -0.699987006671288 9.86545422289099e-07 NA NA NA hsa-miR-338-5p HTR7 -1.19659203838734 0.0100316010080496 -0.17347953123616 0.83432775136575 PITA -0.704843171197738 7.39089657835257e-09 NA NA NA hsa-miR-375 HTR7 -2.94506033785642 0.00570147601654791 -0.17347953123616 0.83432775136575 miRanda -0.360113840200594 4.03157842023499e-12 NA NA NA hsa-let-7a-3p IGF1 0.503048155002889 0.0411145454335299 -2.08273193234781 0.00135003721777342 mirMAP -0.548762647030196 0.00421892046856383 NA NA NA hsa-let-7b-3p IGF1 0.21838629112113 0.296038413622566 -2.08273193234781 0.00135003721777342 mirMAP -0.635547835878874 0.00549026374201425 NA NA NA hsa-let-7f-1-3p IGF1 1.28704406797397 1.17954701106157e-06 -2.08273193234781 0.00135003721777342 mirMAP -0.851363397411719 5.26675622894171e-07 NA NA NA hsa-miR-103a-2-5p IGF1 0.808041560899298 0.019989162317947 -2.08273193234781 0.00135003721777342 mirMAP -0.553669997923913 3.26136051419373e-05 NA NA NA hsa-miR-130b-3p IGF1 1.32714007211004 4.78676252285191e-05 -2.08273193234781 0.00135003721777342 MirTarget -0.899465743270437 2.58112149375995e-11 NA NA NA hsa-miR-15b-3p IGF1 1.75738933306437 3.00554466232543e-08 -2.08273193234781 0.00135003721777342 mirMAP -0.968826693204176 7.96214227786153e-13 NA NA NA hsa-miR-16-1-3p IGF1 1.43227522002564 3.70920454953168e-08 -2.08273193234781 0.00135003721777342 mirMAP -0.890729087705412 1.88566016831073e-07 NA NA NA hsa-miR-181b-5p IGF1 1.64216500592669 1.89228845300725e-08 -2.08273193234781 0.00135003721777342 mirMAP -0.484722871486351 0.00175444902634641 NA NA NA hsa-miR-186-5p IGF1 0.149964130725901 0.434709542998771 -2.08273193234781 0.00135003721777342 mirMAP -0.854024244188329 0.000614672571310158 NA NA NA hsa-miR-19a-3p IGF1 1.26669687448473 0.000105972838514412 -2.08273193234781 0.00135003721777342 MirTarget -0.774005120681808 1.66575604220791e-08 NA NA NA hsa-miR-19b-1-5p IGF1 1.38738648038895 1.3113681938066e-06 -2.08273193234781 0.00135003721777342 mirMAP -0.926821468239418 1.88689070400957e-09 NA NA NA hsa-miR-19b-3p IGF1 0.759818275708988 0.00652779573186786 -2.08273193234781 0.00135003721777342 MirTarget -0.817907622748148 6.24186432835086e-07 NA NA NA hsa-miR-20a-3p IGF1 1.13957127410163 0.000451087640268489 -2.08273193234781 0.00135003721777342 mirMAP -0.98528355307319 2.65793420646273e-13 NA NA NA hsa-miR-27a-3p IGF1 1.29886998470345 2.68986118553486e-08 -2.08273193234781 0.00135003721777342 miRNAWalker2_validate;miRTarBase -0.616931404496154 0.00158345718629553 NA NA NA hsa-miR-301a-3p IGF1 1.44721900431161 6.35068481036652e-06 -2.08273193234781 0.00135003721777342 MirTarget -0.441884252991246 0.00198755452375828 NA NA NA hsa-miR-301b-3p IGF1 1.10080095582241 0.0715568440482997 -2.08273193234781 0.00135003721777342 MirTarget -0.489626457605712 1.80285281431259e-06 NA NA NA hsa-miR-3065-5p IGF1 -0.241623656423063 0.633116553078159 -2.08273193234781 0.00135003721777342 mirMAP -0.280592172239543 0.00303638700940348 NA NA NA hsa-miR-32-3p IGF1 0.583525764322974 0.11837203008551 -2.08273193234781 0.00135003721777342 mirMAP -0.526531906386405 0.000169656014507106 NA NA NA hsa-miR-320a IGF1 0.593888711838028 0.011897419390526 -2.08273193234781 0.00135003721777342 miRNATAP -0.565003176356916 0.00470570622795822 NA NA NA hsa-miR-320b IGF1 1.11183660885284 0.000497971211648503 -2.08273193234781 0.00135003721777342 miRNATAP -0.636268160611304 8.75874676911532e-06 NA NA NA hsa-miR-320c IGF1 0.455072851945474 0.240613785444485 -2.08273193234781 0.00135003721777342 miRNATAP -0.416076292118249 0.00294415535123176 NA NA NA hsa-miR-33a-3p IGF1 0.347011402017138 0.321709379745392 -2.08273193234781 0.00135003721777342 MirTarget -0.68230953278373 8.05008237434513e-07 NA NA NA hsa-miR-3662 IGF1 1.82780708047676 0.0054036501346178 -2.08273193234781 0.00135003721777342 MirTarget -0.445685489349264 6.10879019924172e-07 NA NA NA hsa-miR-421 IGF1 1.80720854070385 1.59709651202848e-07 -2.08273193234781 0.00135003721777342 PITA -0.446185670355332 0.000667970192973034 NA NA NA hsa-miR-454-3p IGF1 0.625199142970745 0.0134890997402741 -2.08273193234781 0.00135003721777342 MirTarget -0.54504877697133 0.00336959864095608 NA NA NA hsa-miR-486-5p IGF1 -0.627607241830911 0.155274583521138 -2.08273193234781 0.00135003721777342 PITA;miRNATAP -0.376922293558939 0.000339259187750958 NA NA NA hsa-miR-576-5p IGF1 0.625714137488957 0.0417100301848969 -2.08273193234781 0.00135003721777342 PITA;mirMAP;miRNATAP -0.758998498936523 3.66567723101284e-07 NA NA NA hsa-miR-577 IGF1 0.911619788986754 0.2256062124148 -2.08273193234781 0.00135003721777342 PITA -0.356762409648375 6.35759889251154e-09 NA NA NA hsa-miR-590-3p IGF1 1.11654983899947 0.000160782154924864 -2.08273193234781 0.00135003721777342 MirTarget;miRanda;mirMAP;miRNATAP -0.61013399064959 8.43840390366035e-05 NA NA NA hsa-miR-592 IGF1 0.779567202789068 0.204498177014474 -2.08273193234781 0.00135003721777342 mirMAP -0.405253750267835 3.79197293554194e-07 NA NA NA hsa-miR-629-5p IGF1 1.06377074768516 0.000536624707722274 -2.08273193234781 0.00135003721777342 mirMAP -0.88383980266392 1.46631776640132e-09 NA NA NA hsa-miR-940 IGF1 1.64406174271686 0.000690854900107004 -2.08273193234781 0.00135003721777342 MirTarget;PITA;miRNATAP -0.451608062622453 5.12340787556199e-05 NA NA NA hsa-let-7f-5p IGF1R 0.634633924115866 0.0344982923411787 -0.553106517250428 0.17432701125411 MirTarget;miRNATAP -0.378400961303142 7.89887847888491e-05 NA NA NA hsa-let-7g-5p IGF1R 0.325297685027927 0.241142963826631 -0.553106517250428 0.17432701125411 MirTarget;miRNATAP -0.544610261720575 1.13359622443088e-07 NA NA NA hsa-miR-140-3p IGF1R -0.296251775392129 0.127539826012144 -0.553106517250428 0.17432701125411 mirMAP -0.422322416904841 0.00570698187046413 24039995 Integrated analysis identified IGF1R as a direct and functional target of miR-140; Knockdown of IGF1R inhibited cell proliferation and invasion resembling that of miR-140 overexpression while overexpression of IGF1R attenuated the function of miR-140 in NSCLC cells; Together our results highlight the significance of miR-140 and IGF1R in the development and progression of NSCLC progression lung squamous cell cancer hsa-miR-148a-5p IGF1R -0.69329616490858 0.0793012233740369 -0.553106517250428 0.17432701125411 mirMAP -0.251757326829035 0.000553171225677268 NA NA NA hsa-miR-150-5p IGF1R 0.147461377429675 0.753719621305461 -0.553106517250428 0.17432701125411 mirMAP -0.163158743338605 0.0082548190347579 NA NA NA hsa-miR-15a-5p IGF1R 1.03783090449383 7.40334108980898e-07 -0.553106517250428 0.17432701125411 miRNATAP -0.500409416506016 0.0002318533448516 NA NA NA hsa-miR-181b-5p IGF1R 1.64216500592669 1.89228845300725e-08 -0.553106517250428 0.17432701125411 miRNAWalker2_validate -0.254937673704192 0.00809085905989163 NA NA NA hsa-miR-192-5p IGF1R 0.0809146624034405 0.941057093528709 -0.553106517250428 0.17432701125411 miRNAWalker2_validate -0.192653791844667 5.90020810511349e-15 NA NA NA hsa-miR-194-3p IGF1R 0.259420201261466 0.821811295418686 -0.553106517250428 0.17432701125411 MirTarget -0.176009400808733 1.76136351271372e-13 NA NA NA hsa-miR-194-5p IGF1R -0.127742909829168 0.906065815804667 -0.553106517250428 0.17432701125411 miRNAWalker2_validate;miRTarBase;miRNATAP -0.196168730805129 3.45873170269679e-15 NA NA NA hsa-miR-196a-5p IGF1R 6.59255881689547 1.53691144193899e-22 -0.553106517250428 0.17432701125411 miRNAWalker2_validate -0.166367126909282 9.5163678851203e-06 NA NA NA hsa-miR-215-5p IGF1R 0.715250240418615 0.573784317311889 -0.553106517250428 0.17432701125411 miRNAWalker2_validate -0.168418028237117 1.74687701753203e-15 NA NA NA hsa-miR-30b-5p IGF1R -0.430720743745757 0.0593564057320791 -0.553106517250428 0.17432701125411 mirMAP -0.349035608361065 0.00668842822760847 NA NA NA hsa-miR-30d-5p IGF1R -0.5492586056147 0.0140125082460125 -0.553106517250428 0.17432701125411 mirMAP;miRNATAP -0.495760465497343 0.000137106101767097 NA NA NA hsa-miR-335-3p IGF1R 2.5197689063267 2.20084506976733e-09 -0.553106517250428 0.17432701125411 MirTarget;mirMAP -0.222943394713827 0.000675759476842365 NA NA NA hsa-miR-335-5p IGF1R 1.59953351087307 5.56170899867314e-05 -0.553106517250428 0.17432701125411 miRNAWalker2_validate -0.300660921541017 2.17486872509834e-05 NA NA NA hsa-miR-34a-5p IGF1R 0.794251341270032 0.00024017386701179 -0.553106517250428 0.17432701125411 miRNAWalker2_validate -0.540234381081216 4.83945332854109e-05 NA NA NA hsa-miR-362-3p IGF1R -0.0349414695893027 0.913780708043777 -0.553106517250428 0.17432701125411 PITA -0.286720174854921 0.00151653552950817 NA NA NA hsa-miR-375 IGF1R -2.94506033785642 0.00570147601654791 -0.553106517250428 0.17432701125411 miRNATAP -0.155241010853673 2.05915373743628e-09 21813472;27129171;24571711 Real-time quantitative PCR was applied to detectthe expression of miR-375 in ESCC samples and its correlation with insulin-like growth factor 1 receptor IGF1R; Further study showed that miR-375 could interact with the 3'-untranslated region of IGF1R and downregulate its expression; In clinical specimens the expression of IGF1R was also negatively correlated with miR-375 expression p=0.008; This study demonstrates that miR-375 has a strong tumour-suppressive effect through inhibiting the expression of IGF1R;Together these results show that AE modulates cancer cells and the tumor microenvironment via activation of miR-375 and by targeting IGF1R and SNAIL1 in OC cells;Epigenetic silencing of miR 375 induces trastuzumab resistance in HER2 positive breast cancer by targeting IGF1R; miR-375 which was downregulated and predicted to target IGF1R in trastuzumab-resistant HER2-positive breast cancer cells could indeed inhibit the cellular luciferase activity in a reporter construct containing the 3'-UTR of IGF1R; A reverse correlation between the levels of miR-375 and IGF1R was validated in clinical breast cancers; Epigenetic silencing of miR-375 causes the upregulation of IGF1R which at least partially underlies trastuzumab resistance of breast cancer cells ;;drug resistance esophageal cancer;ovarian cancer;breast cancer hsa-miR-378c IGF1R -1.27752074861415 2.73676010235611e-05 -0.553106517250428 0.17432701125411 MirTarget;miRNATAP -0.331914273565809 0.000369181287609095 NA NA NA hsa-miR-421 IGF1R 1.80720854070385 1.59709651202848e-07 -0.553106517250428 0.17432701125411 miRanda -0.251977703312655 0.00196650565292646 NA NA NA hsa-miR-429 IGF1R 1.40182602301928 0.00900426780286475 -0.553106517250428 0.17432701125411 miRanda;miRNATAP -0.179305798707313 0.000761816738044031 NA NA NA hsa-miR-500a-3p IGF1R 0.133193057420744 0.668896091969871 -0.553106517250428 0.17432701125411 mirMAP -0.348362935548975 0.000179911177701298 NA NA NA hsa-miR-502-5p IGF1R -0.260297419808178 0.520453580478988 -0.553106517250428 0.17432701125411 PITA;miRNATAP -0.217953361026437 0.00252941658268057 NA NA NA hsa-miR-532-5p IGF1R 0.313080805824184 0.252248939356301 -0.553106517250428 0.17432701125411 miRNATAP -0.648603078037439 2.73220033188001e-10 NA NA NA hsa-miR-577 IGF1R 0.911619788986754 0.2256062124148 -0.553106517250428 0.17432701125411 PITA;miRNATAP -0.167215754453568 1.61689028990584e-05 NA NA NA hsa-miR-592 IGF1R 0.779567202789068 0.204498177014474 -0.553106517250428 0.17432701125411 PITA;miRNATAP -0.221271696492091 8.80961634697948e-06 NA NA NA hsa-miR-625-5p IGF1R 0.537211086526376 0.203801009380384 -0.553106517250428 0.17432701125411 MirTarget -0.252376793200635 0.000225376174409542 NA NA NA hsa-miR-7-1-3p IGF1R 0.709309110750947 0.0412301737463194 -0.553106517250428 0.17432701125411 mirMAP -0.352123862385633 1.86985718445879e-05 NA NA NA hsa-miR-7-5p IGF1R 1.63575693499363 0.0124424214624534 -0.553106517250428 0.17432701125411 miRNAWalker2_validate;mirMAP -0.246386046302912 3.53398011198323e-08 22614005 Moreover the insulin-like growth factor-1 receptor IGF1R oncogene which is often mutated or amplified in human cancers and functions as an important regulator of cell growth and tumor invasion was identified as a direct target of miR-7; Silencing of IGF1R using small interefering RNA siRNA recapitulated the anti-metastatic function of miR-7 whereas restoring the IGF1R expression attenuated the function of miR-7 in GC cells; Finally analyses of miR-7 and IGF1R levels in human primary GC with matched lymph node metastasis tissue arrays revealed that miR-7 is inversely correlated with IGF1R expression metastasis gastric cancer hsa-miR-877-5p IGF1R 2.17859965442336 1.03593450648516e-07 -0.553106517250428 0.17432701125411 MirTarget -0.227979578170498 0.00082244186738806 NA NA NA hsa-miR-98-5p IGF1R 0.919961309193122 2.61963790596372e-05 -0.553106517250428 0.17432701125411 MirTarget -0.440398019671281 0.000811057715877079 NA NA NA hsa-miR-141-3p IGF2 1.45548825076434 0.00115958850961764 0.151877511512816 0.776679031065284 MirTarget;TargetScan -0.284042603011546 0.000670428796943855 NA NA NA hsa-miR-148a-3p IGF2 -1.53721533763578 3.55533747293117e-05 0.151877511512816 0.776679031065284 mirMAP -0.327741863348608 0.00106841626586743 NA NA NA hsa-miR-150-5p IGF2 0.147461377429675 0.753719621305461 0.151877511512816 0.776679031065284 miRNAWalker2_validate -0.388746964133376 9.6405774030514e-07 NA NA NA hsa-miR-200a-3p IGF2 0.717826667295984 0.193912116506827 0.151877511512816 0.776679031065284 MirTarget -0.188922908292284 0.0059568642254884 NA NA NA hsa-miR-34a-5p IGF2 0.794251341270032 0.00024017386701179 0.151877511512816 0.776679031065284 mirMAP -0.473058024257195 0.00742080783257377 NA NA NA hsa-miR-361-3p IGF2 -0.126462931388735 0.566052688733137 0.151877511512816 0.776679031065284 mirMAP -0.487392299771071 0.00566416916707517 NA NA NA hsa-miR-125a-3p IKBKB 1.19506542853853 0.00164364545717311 0.134870081917275 0.507473312093685 miRanda -0.128753900358831 0.000649508610645324 NA NA NA hsa-miR-543 IKBKB 0.0323775903217254 0.929458442755522 0.134870081917275 0.507473312093685 miRanda -0.128643682904471 0.00308168626813573 NA NA NA hsa-miR-125a-5p IKBKG -0.878090699011564 0.000213630844319685 0.482871701565075 0.00797160760932323 miRanda -0.235137534713953 1.20912221589607e-05 NA NA NA hsa-miR-148a-3p IKBKG -1.53721533763578 3.55533747293117e-05 0.482871701565075 0.00797160760932323 mirMAP -0.11630876600781 0.000633185783589711 NA NA NA hsa-let-7a-3p INSR 0.503048155002889 0.0411145454335299 -0.610545747718975 0.0384245633208452 mirMAP -0.410311347775898 1.18425170189008e-06 NA NA NA hsa-let-7b-3p INSR 0.21838629112113 0.296038413622566 -0.610545747718975 0.0384245633208452 mirMAP -0.369834307028296 0.000291538029966231 NA NA NA hsa-let-7b-5p INSR 0.0582902155815681 0.781400138984745 -0.610545747718975 0.0384245633208452 miRNATAP -0.526549443920689 1.31398968291732e-07 NA NA NA hsa-miR-127-5p INSR 0.684144175589776 0.021634535736883 -0.610545747718975 0.0384245633208452 PITA -0.330819457908089 1.85622777870309e-06 NA NA NA hsa-miR-15b-3p INSR 1.75738933306437 3.00554466232543e-08 -0.610545747718975 0.0384245633208452 mirMAP -0.221503872117918 0.000522115172240783 NA NA NA hsa-miR-205-5p INSR 3.13520672931882 0.0293226471971167 -0.610545747718975 0.0384245633208452 mirMAP -0.131303947182585 2.09940673475484e-24 NA NA NA hsa-miR-27a-3p INSR 1.29886998470345 2.68986118553486e-08 -0.610545747718975 0.0384245633208452 miRNATAP -0.618262769375196 8.16350445855504e-14 NA NA NA hsa-miR-27b-3p INSR 0.0836323965901755 0.725273923274 -0.610545747718975 0.0384245633208452 miRNATAP -0.466805472556421 9.42259622619392e-08 NA NA NA hsa-miR-539-5p INSR -0.189590870053519 0.584280352847564 -0.610545747718975 0.0384245633208452 mirMAP -0.16609214047185 0.00677848187570433 NA NA NA hsa-miR-149-5p KDR 0.706277554734069 0.296848731347677 -0.700906973648848 0.0493591792780238 miRNATAP -0.219672189869555 1.13049786050969e-09 NA NA NA hsa-miR-23a-3p KDR 1.10685926969665 3.16223452471768e-08 -0.700906973648848 0.0493591792780238 mirMAP -0.553407435563254 7.15413862125e-06 NA NA NA hsa-let-7a-3p KIT 0.503048155002889 0.0411145454335299 -3.33532221246538 5.36354430486114e-10 mirMAP -0.457611683794333 0.0053658743402956 NA NA NA hsa-let-7b-3p KIT 0.21838629112113 0.296038413622566 -3.33532221246538 5.36354430486114e-10 mirMAP -0.599934919122108 0.00216223528866986 NA NA NA hsa-let-7f-1-3p KIT 1.28704406797397 1.17954701106157e-06 -3.33532221246538 5.36354430486114e-10 mirMAP -0.778831542315825 7.29328978606976e-08 NA NA NA hsa-miR-125a-3p KIT 1.19506542853853 0.00164364545717311 -3.33532221246538 5.36354430486114e-10 miRanda -0.318966721421995 0.0025253706672714 NA NA NA hsa-miR-128-3p KIT 0.98280381420517 5.77641850797209e-05 -3.33532221246538 5.36354430486114e-10 MirTarget -0.874953900602502 3.36351962635737e-08 NA NA NA hsa-miR-130b-3p KIT 1.32714007211004 4.78676252285191e-05 -3.33532221246538 5.36354430486114e-10 miRNATAP -0.686674632256951 4.36629799890082e-09 NA NA NA hsa-miR-142-5p KIT 1.55592486377018 6.69269968016779e-06 -3.33532221246538 5.36354430486114e-10 PITA;miRNATAP -0.31795809800069 0.00515222206463945 NA NA NA hsa-miR-193b-3p KIT 0.281752012268679 0.451258902263119 -3.33532221246538 5.36354430486114e-10 MirTarget;miRNATAP -0.420280907821218 7.88590038010478e-05 NA NA NA hsa-miR-19a-3p KIT 1.26669687448473 0.000105972838514412 -3.33532221246538 5.36354430486114e-10 miRTarBase;miRNATAP -0.494580974616647 3.59731270026218e-05 NA NA NA hsa-miR-19b-3p KIT 0.759818275708988 0.00652779573186786 -3.33532221246538 5.36354430486114e-10 miRNATAP -0.438659680261463 0.00221816743653445 NA NA NA hsa-miR-20a-5p KIT 1.4503375861709 5.7813456424762e-07 -3.33532221246538 5.36354430486114e-10 miRTarBase -0.666247140106509 4.53421650677625e-07 NA NA NA hsa-miR-221-3p KIT 1.33496247538338 3.82022531235275e-07 -3.33532221246538 5.36354430486114e-10 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.604461925069444 4.2460697504279e-05 NA NA NA hsa-miR-222-3p KIT 1.39382731585819 9.98182478024671e-07 -3.33532221246538 5.36354430486114e-10 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.50158065490246 0.000246393891203869 NA NA NA hsa-miR-301a-3p KIT 1.44721900431161 6.35068481036652e-06 -3.33532221246538 5.36354430486114e-10 miRNATAP -0.368287445064243 0.00264001195314497 NA NA NA hsa-miR-335-3p KIT 2.5197689063267 2.20084506976733e-09 -3.33532221246538 5.36354430486114e-10 mirMAP -0.458566715976481 2.57393601959522e-07 NA NA NA hsa-miR-335-5p KIT 1.59953351087307 5.56170899867314e-05 -3.33532221246538 5.36354430486114e-10 miRNAWalker2_validate -0.30483031884429 0.00208266201101367 NA NA NA hsa-miR-421 KIT 1.80720854070385 1.59709651202848e-07 -3.33532221246538 5.36354430486114e-10 miRanda -0.480032182318911 1.61505437326823e-05 NA NA NA hsa-miR-505-3p KIT 0.82660100642669 0.00111666333288398 -3.33532221246538 5.36354430486114e-10 MirTarget;miRNATAP -0.619295605268503 7.59316931695544e-05 NA NA NA hsa-miR-590-3p KIT 1.11654983899947 0.000160782154924864 -3.33532221246538 5.36354430486114e-10 miRanda;mirMAP -0.551250130230434 3.22536461118127e-05 NA NA NA hsa-miR-671-5p KIT 0.947458646379882 0.0024732430914236 -3.33532221246538 5.36354430486114e-10 MirTarget -0.486032819220924 0.000120130312458852 NA NA NA hsa-miR-126-5p KITLG 0.41765430251855 0.0753161203651532 -0.607435958715551 0.0719318599533199 mirMAP -0.303453273757017 0.00341568253113024 NA NA NA hsa-miR-142-5p KITLG 1.55592486377018 6.69269968016779e-06 -0.607435958715551 0.0719318599533199 MirTarget;PITA -0.223438305401041 0.00100350853220116 NA NA NA hsa-miR-17-3p KITLG 1.31126744284937 3.24768335024185e-07 -0.607435958715551 0.0719318599533199 MirTarget -0.337659809050111 0.000210714704718847 NA NA NA hsa-miR-32-3p KITLG 0.583525764322974 0.11837203008551 -0.607435958715551 0.0719318599533199 mirMAP -0.192413963699601 0.00804792243342359 NA NA NA hsa-miR-320b KITLG 1.11183660885284 0.000497971211648503 -0.607435958715551 0.0719318599533199 MirTarget;PITA;miRanda -0.213380632178247 0.004252072621555 NA NA NA hsa-miR-335-3p KITLG 2.5197689063267 2.20084506976733e-09 -0.607435958715551 0.0719318599533199 MirTarget -0.181659303251703 0.000850153035697802 NA NA NA hsa-miR-33a-3p KITLG 0.347011402017138 0.321709379745392 -0.607435958715551 0.0719318599533199 mirMAP -0.253185683355659 0.000449861177695944 NA NA NA hsa-miR-452-3p KITLG 2.2028815467959 0.00185370432491004 -0.607435958715551 0.0719318599533199 mirMAP -0.119703988766594 0.00151418203650555 NA NA NA hsa-miR-590-3p KITLG 1.11654983899947 0.000160782154924864 -0.607435958715551 0.0719318599533199 MirTarget;PITA;miRanda -0.242928577796156 0.00251186203169612 NA NA NA hsa-let-7a-3p KRAS 0.503048155002889 0.0411145454335299 0.0440663168558286 0.888218969585117 mirMAP;miRNATAP -0.274880026464494 0.00252165954052568 24727325;20603437;24890702;23324806;21994416;23167843;27620744;20177422;25183481;22584434;18922928 Association study of the let 7 miRNA complementary site variant in the 3' untranslated region of the KRAS gene in stage III colon cancer NCCTG N0147 Clinical Trial; A let-7 microRNA-complementary site LCS6 polymorphism in the 3' untranslated region of the KRAS gene has been shown to disrupt let-7 binding and upregulate KRAS expression;A let 7 microRNA binding site polymorphism in 3' untranslated region of KRAS gene predicts response in wild type KRAS patients with metastatic colorectal cancer treated with cetuximab monotherapy; A polymorphism in a let-7 microRNA complementary site lcs6 in the KRAS 3' untranslated region UTR is associated with an increased cancer risk in non-small-cell lung cancer and reduced overall survival OS in oral cancers; the presence of KRAS let-7 lcs6 polymorphism was evaluated in 130 mCRC patients who were enrolled in a phase II study of cetuximab monotherapy IMCL-0144; KRAS let-7 lcs6 polymorphism was found to be related to object response rate ORR in mCRC patients whose tumors had KRASwt;Let 7 microRNA binding site polymorphism in the 3'UTR of KRAS and colorectal cancer outcome: a systematic review and meta analysis; There is a small but growing body of literature regarding the predictive utility of a Let-7 microRNA-binding-site polymorphism in the 3'-untranslated region UTR of KRAS KRAS-LCS6 for colorectal cancer outcome although the results are conflicting; A PubMed search was conducted to identify all studies reporting on KRAS let-7 microRNA-binding site polymorphism LCS6; rs61764370 and colorectal cancer outcome;The LCS6 polymorphism in the binding site of let 7 microRNA to the KRAS 3' untranslated region: its role in the efficacy of anti EGFR based therapy in metastatic colorectal cancer patients; The lethal-7 let-7 family of microRNAs regulates KRAS activity; We studied the association of the KRAS let-7 LCS6 polymorphism with the response in 100 refractory mCRC patients treated with anti-EGFR antibodies; The KRAS let-7 LCS6 polymorphism was genotyped using the BioMark system in blood and tumor DNA samples; The KRAS let-7 LCS6 G-allele showed a statistically significant association with nonresponse to anti-EGFR-based treatment: 31.9% of patients with the T/T genotype presented a complete or a partial response versus no patients with T/G or G/G genotypes P=0.004;A let 7 microRNA SNP in the KRAS 3'UTR is prognostic in early stage colorectal cancer; Recently a SNP in a lethal-7 let-7 miRNA complementary site LCS6 in the KRAS 3'untranslated region was suggested to affect survival in metastatic CRC;Let 7 miRNA binding site polymorphism in the KRAS 3'UTR; colorectal cancer screening population prevalence and influence on clinical outcome in patients with metastatic colorectal cancer treated with 5 fluorouracil and oxaliplatin +/ cetuximab; Recent studies have reported associations between a variant allele in a let-7 microRNA complementary site LCS6 within the 3'untranslated region 3'UTR of KRAS rs61764370 and clinical outcome in metastatic colorectal cancer mCRC patients receiving cetuximab;A let 7 microRNA binding site polymorphism in the KRAS 3'UTR is associated with increased risk and reduced survival for gallbladder cancer in North Indian population; The let-7 microRNAs play a key role in regulating KRAS expression and a polymorphism in 3' untranslated region rs61764370 T/G of KRAS leads to its higher expression;Genetic modulation of the Let 7 microRNA binding to KRAS 3' untranslated region and survival of metastatic colorectal cancer patients treated with salvage cetuximab irinotecan; There is increasing evidence that the Let-7 microRNA miRNA exerts an effect as a tumor suppressor by targeting the KRAS mRNA; The Let-7 complementary site LCS6 T>G variant in the KRAS 3'-untranslated region weakens Let-7 binding;A let 7 microRNA binding site polymorphism in KRAS predicts improved outcome in patients with metastatic colorectal cancer treated with salvage cetuximab/panitumumab monotherapy;High let 7a microRNA levels in KRAS mutated colorectal carcinomas may rescue anti EGFR therapy effects in patients with chemotherapy refractory metastatic disease; Preclinical and experimental data in vivo indicate that Lethal-7 Let-7 microRNA downregulates KRAS with antitumor effects in the presence of activating KRAS mutations; In 59 patients harboring KRAS mutations Let-7a levels were analyzed for association with overall survival OS and progression-free survival PFS times; An exploratory subgroup analysis was performed using the rs61764370 LCS6 T>G polymorphism that experimentally impairs Let-7 binding to KRAS mRNA; In patients with KRAS mutations Let-7a analysis may serve to identify subgroups of patients who may still benefit from EGFR inhibition and this may open up new perspectives for alternative treatment strategies;A SNP in a let 7 microRNA complementary site in the KRAS 3' untranslated region increases non small cell lung cancer risk; The purpose of this study was to identify single nucleotide polymorphisms SNP that could modify let-7 binding and to assess the effect of such SNPs on target gene regulation and risk for non-small cell lung cancer NSCLC let-7 complementary sites LCS were sequenced in the KRAS 3' untranslated region from 74 NSCLC cases to identify mutations and SNPs that correlated with NSCLC; The LCS6 variant allele in a KRAS miRANA complementary site is significantly associated with increased risk for NSCLC among moderate smokers and represents a new paradigm for let-7 miRNAs in lung cancer susceptibility staging;drug resistance;poor survival;;drug resistance;staging;poor survival;;poor survival;poor survival;;progression;poor survival; colon cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;bladder cancer;colorectal cancer;colorectal cancer;colorectal cancer;lung squamous cell cancer hsa-miR-143-3p KRAS -0.661937718854688 0.0483213962135842 0.0440663168558286 0.888218969585117 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.177845989861529 0.00743791491988655 22804917;27725862;19137007;26581910;23173124;26824186;21197560 In KRAS mutated tumours increased miR-200b and decreased miR-143 expression were associated with a good PFS;The expression of miR-143 is often down-regulated and it might play an important role by targeting KRAS in colorectal cancer CRC; Dual-luciferase reporter assays were performed to validate whether KRAS was regulated by miR-143; Dual-luciferase assays indicated that KRAS was a direct target of miR-143 as subsequently demonstrated by qPCR and western blot analysis showing that infection of SW480 cells with Ad-ZD55-miR-143 resulted in the down-regulation of KRAS at both mRNA and protein levels;Role of miR 143 targeting KRAS in colorectal tumorigenesis; In particular among a panel of presumed targets generated by in silico analysis that may interact with these aberrantly expressed miRNAs KRAS oncogene has been further experimentally validated as the target of miR-143; First an inverse correlation between KRAS protein and miR-143 in vivo was found; Second KRAS expression in Lovo cells was significantly abolished by treatment with miR-143 mimic whereas miR-143 inhibitor increased KRAS protein level; Third luciferase reporter assay confirmed that miR-143 directly recognize the 3'-untranslated region of KRAS transcripts; Finally inhibition of KRAS expression by miR-143 inhibits constitutive phosphorylation of ERK1/2; Taken together the present study provides the first evidences that miR-143 is significant in suppressing colorectal cancer cell growth through inhibition of KRAS translation;MicroRNA 143 replenishment re sensitizes colorectal cancer cells harboring mutant but not wild type KRAS to paclitaxel treatment; Our results showed that miR-143 but not let-7b increased sensitization of KRAS mutant tumor cells to paclitaxel; Furthermore transfection of miR-143 but not let-7b mimic negatively regulated the expression of mutant but not wild-type KRAS; Combination of miR-143 mimic and paclitaxel induced the onset of apoptosis and reverted in vitro metastatic properties migration and invasion in KRAS mutant tumor cells; MiR-143 thus can be used as a chemosensitizer for the treatment of KRAS mutant tumors and warrants further investigations in in vitro and pre-clinical in vivo models;In turn the level of miR-143 in CRC cells decreasing the amount of MACC1 metastasis-associated in colon cancer-1 and oncogenic KRAS protein may be utilized as a prognostic marker;Stable miR-143 or miR-145 overexpression increased cell sensitivity to cetuximab resulting in a significant increase of cetuximab-mediated ADCC independently of KRAS status;miR 143 decreases prostate cancer cells proliferation and migration and enhances their sensitivity to docetaxel through suppression of KRAS; The expression level of miR-143 and its target gene KRAS were measured by realtime PCR and western blotting respectively; Our results revealed an inverse correlation of expression between miR-143 and KRAS protein in prostate cancer samples Pearson's correlation scatter plots: R = -0.707 P < 0.05; These findings suggest that miR-143 plays an important role in prostate cancer proliferation migration and chemosensitivity by suppressing KRAS and subsequent inactivation of MAPK pathway which provides a potential development of a new approach for the treatment of prostate cancer ;;tumorigenesis;;metastasis;; colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colon cancer;prostate cancer hsa-miR-193b-3p KRAS 0.281752012268679 0.451258902263119 0.0440663168558286 0.888218969585117 miRNAWalker2_validate;MirTarget;miRNATAP -0.202900424593209 0.000628014078688691 25905463 Deregulation of the MiR 193b KRAS Axis Contributes to Impaired Cell Growth in Pancreatic Cancer; Mechanistically KRAS was verified as a direct effector of miR-193b through which the AKT and ERK pathways were modulated and cell growth of PDAC cells was suppressed; Taken together our findings indicate that miR-193b-mediated deregulation of the KRAS axis is involved in pancreatic carcinogenesis and suggest that miR-193b could be a potentially effective target for PDAC therapy tumorigenesis pancreatic cancer hsa-miR-224-3p KRAS 1.52422171450716 0.00650463542340912 0.0440663168558286 0.888218969585117 mirMAP -0.113759821037082 0.00837068880275088 25919696 MicroRNA 224 is associated with colorectal cancer progression and response to 5 fluorouracil based chemotherapy by KRAS dependent and independent mechanisms; MicroRNA-224 was differentially expressed in dysplastic colorectal disease and in isogeneic KRAS WT and mutant HCT116 cells; 5-FU chemosensitivity was significantly increased in miR-224 knockdown cells and in NIH3T3 cells expressing KRAS and BRAF mutant proteins progression;drug resistance colorectal cancer hsa-miR-27b-3p KRAS 0.0836323965901755 0.725273923274 0.0440663168558286 0.888218969585117 miRNATAP -0.310127956853884 0.00104691607104432 NA NA NA hsa-miR-30d-5p KSR1 -0.5492586056147 0.0140125082460125 0.140890125779206 0.612157398853349 MirTarget -0.233591578677937 0.00885879183829494 NA NA NA hsa-miR-205-5p KSR2 3.13520672931882 0.0293226471971167 -1.21370263052714 0.0492472934792369 mirMAP -0.115873666757155 0.000121458264301249 NA NA NA hsa-miR-2355-5p KSR2 0.594869787574182 0.120591076715177 -1.21370263052714 0.0492472934792369 mirMAP -0.478701743656917 2.52671166830017e-05 NA NA NA hsa-miR-23a-3p KSR2 1.10685926969665 3.16223452471768e-08 -1.21370263052714 0.0492472934792369 mirMAP -1.04412448257205 9.07792372596112e-07 NA NA NA hsa-miR-330-5p KSR2 0.488365986827708 0.0512207630808233 -1.21370263052714 0.0492472934792369 miRNATAP -0.466314240123994 0.008767396458134 NA NA NA hsa-miR-34c-3p KSR2 2.25273698056457 9.06191072601281e-05 -1.21370263052714 0.0492472934792369 mirMAP -0.207546716489862 0.00638602575640636 NA NA NA hsa-miR-3682-3p KSR2 1.96838261925327 4.94885331227292e-06 -1.21370263052714 0.0492472934792369 mirMAP -0.343955801796148 0.00375771306430089 NA NA NA hsa-miR-452-3p KSR2 2.2028815467959 0.00185370432491004 -1.21370263052714 0.0492472934792369 mirMAP -0.234310650234868 0.000691376626964227 NA NA NA hsa-miR-452-5p KSR2 2.08756506185889 0.000258095769002813 -1.21370263052714 0.0492472934792369 mirMAP -0.217694610637202 0.00406302208892941 NA NA NA hsa-miR-455-5p KSR2 1.20462751989145 6.74386011867484e-05 -1.21370263052714 0.0492472934792369 mirMAP -0.646300826798788 5.11792971578193e-06 NA NA NA hsa-miR-101-3p MAP2K1 -0.451263906815861 0.0283387250173031 0.350529324467741 0.0294686130211343 miRNAWalker2_validate -0.210543062942234 0.00016389062492995 NA NA NA hsa-miR-140-3p MAP2K1 -0.296251775392129 0.127539826012144 0.350529324467741 0.0294686130211343 PITA -0.25457882041555 1.7173921304805e-05 NA NA NA hsa-miR-30c-5p MAP2K1 -0.983130268805942 4.60419218706127e-05 0.350529324467741 0.0294686130211343 miRNAWalker2_validate -0.187593003082029 5.3436762450792e-05 NA NA NA hsa-miR-497-5p MAP2K1 -0.801030912431774 0.00360386743876612 0.350529324467741 0.0294686130211343 miRNAWalker2_validate -0.227085834893879 1.53919190373316e-08 NA NA NA hsa-miR-126-5p MAPK1 0.41765430251855 0.0753161203651532 -0.495098981122446 0.000571417199694919 mirMAP -0.124608202204108 0.00475675613750838 NA NA NA hsa-miR-140-3p MAPK1 -0.296251775392129 0.127539826012144 -0.495098981122446 0.000571417199694919 PITA;miRNATAP -0.145247944412064 0.0071251228758136 NA NA NA hsa-miR-140-5p MAPK1 0.208193069681326 0.303002433893804 -0.495098981122446 0.000571417199694919 miRanda -0.168814127617461 0.00108046906118217 NA NA NA hsa-miR-142-5p MAPK1 1.55592486377018 6.69269968016779e-06 -0.495098981122446 0.000571417199694919 mirMAP -0.122335014287939 1.92619380509704e-05 NA NA NA hsa-miR-16-5p MAPK1 1.00515772948091 5.33912942007619e-06 -0.495098981122446 0.000571417199694919 mirMAP -0.128343010905179 0.00527308486345473 NA NA NA hsa-miR-17-3p MAPK1 1.31126744284937 3.24768335024185e-07 -0.495098981122446 0.000571417199694919 mirMAP -0.106169760608366 0.00660645385547114 NA NA NA hsa-miR-32-5p MAPK1 0.415247682945382 0.106458022460373 -0.495098981122446 0.000571417199694919 mirMAP -0.131661373347466 0.00100556712965003 NA NA NA hsa-miR-320a MAPK1 0.593888711838028 0.011897419390526 -0.495098981122446 0.000571417199694919 miRNAWalker2_validate;PITA;miRanda;miRNATAP -0.124406693534882 0.00441330639927605 NA NA NA hsa-miR-320b MAPK1 1.11183660885284 0.000497971211648503 -0.495098981122446 0.000571417199694919 PITA;miRanda;miRNATAP -0.118699294587812 0.000165603061513233 NA NA NA hsa-miR-3614-3p MAPK1 0.816988052098069 0.0143572924352078 -0.495098981122446 0.000571417199694919 mirMAP -0.143042145876837 4.60745685333775e-06 NA NA NA hsa-miR-19a-3p MAPK10 1.26669687448473 0.000105972838514412 -1.47838450058589 0.0146695449243249 miRNATAP -0.524620072624796 5.21292571232218e-05 NA NA NA hsa-miR-19b-3p MAPK10 0.759818275708988 0.00652779573186786 -1.47838450058589 0.0146695449243249 miRNATAP -0.446352029711074 0.00407749072585118 NA NA NA hsa-miR-221-3p MAPK10 1.33496247538338 3.82022531235275e-07 -1.47838450058589 0.0146695449243249 miRNATAP -0.480525331298863 0.00291630181964075 NA NA NA hsa-miR-222-3p MAPK10 1.39382731585819 9.98182478024671e-07 -1.47838450058589 0.0146695449243249 miRNATAP -0.559621471278604 0.000154746484340658 NA NA NA hsa-miR-29a-3p MAPK10 -0.113012156986374 0.615005009685815 -1.47838450058589 0.0146695449243249 miRNATAP -0.59141099824068 0.00261044477988932 NA NA NA hsa-miR-29b-3p MAPK10 -0.230693226193598 0.367461626035234 -1.47838450058589 0.0146695449243249 miRNATAP -0.60205184803829 0.00041835019777687 24767251 The percentage of positive myeloid cell leukemia sequence 1 ATG9A and MAPK10 protein expression and low miR-29b mRNA expression were significantly higher in cases with clinical stage III and IV ovarian cancer than in cases with clinical stage II ovarian cancer; Univariate Kaplan-Meier analysis showed a negative correlation between MAPK10 or ATG9A protein expression and overall as well as progression-free survival whereas a positive correlation was observed between miR-29b mRNA expression and overall as well as progression-free survival; Multivariate Cox regression analysis showed that elevated MAPK10 or ATG9A protein and lowered miR-29b mRNA expression in ovarian carcinoma was an independent poor prognostic predictor; Our study suggested that miR-29b mRNA MAPK10 protein expression and ATG9A protein expression are closely related to chemosensitivity of ovarian carcinoma staging;progression;poor survival ovarian cancer hsa-miR-429 MAPK10 1.40182602301928 0.00900426780286475 -1.47838450058589 0.0146695449243249 miRNATAP -0.299587023670623 0.000162775320837701 NA NA NA hsa-miR-590-3p MAPK10 1.11654983899947 0.000160782154924864 -1.47838450058589 0.0146695449243249 miRanda;mirMAP -0.435912555464834 0.00265451734998232 NA NA NA hsa-miR-590-5p MAPK10 1.04171442093217 0.000272475544954865 -1.47838450058589 0.0146695449243249 PITA;miRanda;miRNATAP -0.504910398592333 0.000753214066446178 NA NA NA hsa-miR-130a-3p MAPK8 0.146223920674657 0.633739795905839 0.047155182901105 0.800634305321577 mirMAP -0.142153642233879 0.000967428320783935 NA NA NA hsa-miR-193b-3p MAPK8 0.281752012268679 0.451258902263119 0.047155182901105 0.800634305321577 miRNAWalker2_validate -0.110566260184176 0.00170018129216572 NA NA NA hsa-miR-214-3p MAPK8 1.01201534142544 0.00625092909225755 0.047155182901105 0.800634305321577 miRNAWalker2_validate -0.100393295669915 0.00454338816784626 19859982 HeLa cells that stably overexpress miR-214 downregulate the expression of MEK3 and JNK1 at both mRNA and protein levels; Further investigation revealed that miR-214 regulates the expression of MEK3 and JNK1 by targeting the 3'UTRs of these genes; Collectively these results suggest that miR-214 negatively regulates HeLa cell proliferation by targeting the noncoding regions of MEK3 and JNK1 mRNAs cervical and endocervical cancer hsa-miR-22-5p MAPK8 0.804348748654247 0.000804065112767412 0.047155182901105 0.800634305321577 mirMAP -0.160857639824075 0.00339109702841305 NA NA NA hsa-let-7i-5p MAPK9 0.798954594465461 2.99735653959449e-05 -0.457166211786093 0.00433538908909622 miRNATAP -0.162923938978581 0.00646417150753322 NA NA NA hsa-miR-199a-3p MAPK9 0.85352674491639 0.000360518331912285 -0.457166211786093 0.00433538908909622 miRNAWalker2_validate -0.148619430258245 0.00173860851866056 NA NA NA hsa-miR-24-3p MAPK9 1.08578167539644 6.18549359075268e-07 -0.457166211786093 0.00433538908909622 miRNATAP -0.165659037825773 0.00129654715142099 NA NA NA hsa-miR-27b-3p MAPK9 0.0836323965901755 0.725273923274 -0.457166211786093 0.00433538908909622 miRNAWalker2_validate -0.145750595301133 0.00269156719381644 NA NA NA hsa-miR-139-5p MET -1.83374360776637 1.22019901002824e-09 1.09146649208404 0.00117906068907057 miRanda -0.24593624886584 0.0013860217001924 NA NA NA hsa-miR-23b-3p MET -0.286465516491361 0.18664668472995 1.09146649208404 0.00117906068907057 miRNAWalker2_validate;miRTarBase -0.36770947393715 0.00116708700486341 19490101 MicroRNA 23b mediates urokinase and c met downmodulation and a decreased migration of human hepatocellular carcinoma cells; In the present study to understand whether the expression of these genes might be coregulated by specific microRNAs miRs in human cells we predicted that Homo sapiens microRNA-23b could recognize two sites in the 3'-UTR of uPA and four sites in the c-met 3'-UTR by the algorithm pictar; The evidence obtained shows that overexpression of miR-23b leads to uPA and c-met downregulation and to decreased migration and proliferation abilities of HCC cells liver cancer hsa-miR-30e-3p MET -0.913131357083321 7.29096855615228e-06 1.09146649208404 0.00117906068907057 mirMAP -0.405368273360062 0.000591001266617717 NA NA NA hsa-miR-340-5p MET -0.164941927483643 0.529910509321278 1.09146649208404 0.00117906068907057 miRNAWalker2_validate;miRTarBase -0.476856920131876 1.58791963714124e-07 24448820;21692045 It was of note that the colorectal cancer group with low miR-340 and high c-Met expression had the worst prognosis;miR 340 inhibition of breast cancer cell migration and invasion through targeting of oncoprotein c Met; Ex vivo loss of miR-340 expression was associated with lymph node metastasis high tumor histological grade clinical stage and shorter overall survival of breast cancer as well as increased c-Met expression in breast cancer tissue specimens worse prognosis;cell migration;staging;metastasis;poor survival colorectal cancer;breast cancer hsa-miR-361-5p MET 0.407725414130987 0.0181260969156347 1.09146649208404 0.00117906068907057 PITA;miRanda -0.423329864611604 0.00332602842271318 NA NA NA hsa-miR-374a-5p MET -0.116485410477589 0.554703396010082 1.09146649208404 0.00117906068907057 mirMAP -0.374730510349824 0.00289010914037555 NA NA NA hsa-miR-664a-3p MET -0.83041219170254 0.000136267547251167 1.09146649208404 0.00117906068907057 mirMAP -0.372775395356499 0.000770233233738383 NA NA NA hsa-miR-130b-5p MRAS 0.701350393759937 0.0510142718395002 -0.93856327130669 0.01022886035931 mirMAP -0.352489233850365 7.48315963886491e-07 NA NA NA hsa-miR-135b-5p MRAS 4.09156383496059 1.32294295002438e-12 -0.93856327130669 0.01022886035931 miRNATAP -0.207106279307674 6.542401185588e-07 NA NA NA hsa-miR-15a-5p MRAS 1.03783090449383 7.40334108980898e-07 -0.93856327130669 0.01022886035931 miRNATAP -0.434870200897066 0.000401088723644211 NA NA NA hsa-miR-15b-5p MRAS 1.62046407540723 5.42152621571078e-09 -0.93856327130669 0.01022886035931 miRNATAP -0.435414108925877 1.08210708843648e-06 NA NA NA hsa-miR-16-5p MRAS 1.00515772948091 5.33912942007619e-06 -0.93856327130669 0.01022886035931 miRNATAP -0.431323426373678 0.000219744863833023 NA NA NA hsa-miR-182-5p MRAS 0.887369486030646 0.0310640781418789 -0.93856327130669 0.01022886035931 miRNATAP -0.2695020582748 1.60612116167232e-05 NA NA NA hsa-miR-32-3p MRAS 0.583525764322974 0.11837203008551 -0.93856327130669 0.01022886035931 mirMAP -0.327873546858812 2.57190000263241e-05 NA NA NA hsa-miR-330-5p MRAS 0.488365986827708 0.0512207630808233 -0.93856327130669 0.01022886035931 miRanda -0.39855941917819 0.000137455548651093 NA NA NA hsa-miR-335-3p MRAS 2.5197689063267 2.20084506976733e-09 -0.93856327130669 0.01022886035931 mirMAP -0.266508913361864 5.24918701905074e-06 NA NA NA hsa-miR-33a-3p MRAS 0.347011402017138 0.321709379745392 -0.93856327130669 0.01022886035931 mirMAP -0.348087364894607 7.50558044495045e-06 NA NA NA hsa-miR-421 MRAS 1.80720854070385 1.59709651202848e-07 -0.93856327130669 0.01022886035931 miRanda -0.249502867228814 0.000664493612902864 NA NA NA hsa-miR-429 MRAS 1.40182602301928 0.00900426780286475 -0.93856327130669 0.01022886035931 miRanda;miRNATAP -0.303359734134872 5.07340918220063e-11 NA NA NA hsa-miR-652-3p MRAS 1.02742852909286 0.000337974815149397 -0.93856327130669 0.01022886035931 miRNAWalker2_validate -0.463233951112132 1.6097470965954e-07 NA NA NA hsa-miR-7-1-3p MRAS 0.709309110750947 0.0412301737463194 -0.93856327130669 0.01022886035931 mirMAP -0.303513851388767 4.54855158162686e-05 NA NA NA hsa-miR-96-5p MRAS 1.14243043653372 0.00942969392739105 -0.93856327130669 0.01022886035931 TargetScan;miRNATAP -0.288537748500801 2.06964631451897e-06 NA NA NA hsa-miR-193b-3p NF1 0.281752012268679 0.451258902263119 0.296660298716273 0.141340363425621 miRNAWalker2_validate -0.139046924141261 0.000256494343862068 NA NA NA hsa-miR-27a-3p NF1 1.29886998470345 2.68986118553486e-08 0.296660298716273 0.141340363425621 MirTarget -0.184606843234685 0.00196035817935508 NA NA NA hsa-miR-27b-3p NF1 0.0836323965901755 0.725273923274 0.296660298716273 0.141340363425621 MirTarget -0.16412670011364 0.00718453960999936 NA NA NA hsa-let-7f-5p NGF 0.634633924115866 0.0344982923411787 -0.0044354260251589 0.994557609636983 MirTarget -0.455658818520987 0.00313618077968416 NA NA NA hsa-let-7g-5p NGF 0.325297685027927 0.241142963826631 -0.0044354260251589 0.994557609636983 MirTarget -0.833551967281976 3.8902528304102e-07 NA NA NA hsa-miR-423-5p NGF 0.832613878736338 0.000791321227103338 -0.0044354260251589 0.994557609636983 MirTarget;miRNATAP -0.706016056377721 0.0001322029752225 NA NA NA hsa-miR-429 NGF 1.40182602301928 0.00900426780286475 -0.0044354260251589 0.994557609636983 miRanda -0.396695496445767 2.17739891550587e-06 NA NA NA hsa-miR-10a-5p NGFR -0.470861534765518 0.148803248989189 -1.73466388982039 0.0507168927156123 mirMAP -0.655944380730205 0.000740118227620395 NA NA NA hsa-miR-148b-5p NGFR 1.04409494910362 0.00195860954157389 -1.73466388982039 0.0507168927156123 mirMAP -0.664475438733519 0.000347024130079685 NA NA NA hsa-miR-194-3p NGFR 0.259420201261466 0.821811295418686 -1.73466388982039 0.0507168927156123 mirMAP -0.543264706935227 6.86605025324571e-30 NA NA NA hsa-miR-2110 NGFR 0.759864042760204 0.0723961390557655 -1.73466388982039 0.0507168927156123 mirMAP -0.888664374578289 1.2224682980101e-09 NA NA NA hsa-miR-30b-3p NGFR -0.266398938200332 0.400847813143994 -1.73466388982039 0.0507168927156123 mirMAP -0.631471380811439 0.00166272552987571 NA NA NA hsa-miR-326 NGFR -0.429748586406214 0.2629894124021 -1.73466388982039 0.0507168927156123 miRanda;mirMAP -0.612828274615561 0.000225550321617984 NA NA NA hsa-miR-335-5p NGFR 1.59953351087307 5.56170899867314e-05 -1.73466388982039 0.0507168927156123 miRNAWalker2_validate -0.631051526978649 4.83987514130979e-05 NA NA NA hsa-miR-34a-5p NGFR 0.794251341270032 0.00024017386701179 -1.73466388982039 0.0507168927156123 mirMAP -1.41009174140321 1.00424432427002e-06 NA NA NA hsa-miR-361-3p NGFR -0.126462931388735 0.566052688733137 -1.73466388982039 0.0507168927156123 mirMAP -0.975124688217581 0.000853156267133635 NA NA NA hsa-miR-3614-5p NGFR 1.10426689932954 0.00706308396674599 -1.73466388982039 0.0507168927156123 mirMAP -0.894416105030557 2.76089018532704e-09 NA NA NA hsa-miR-429 NGFR 1.40182602301928 0.00900426780286475 -1.73466388982039 0.0507168927156123 miRNATAP -0.588824010286522 2.62214803568559e-07 NA NA NA hsa-miR-625-5p NGFR 0.537211086526376 0.203801009380384 -1.73466388982039 0.0507168927156123 mirMAP -1.07769856228856 2.78511975581827e-14 NA NA NA hsa-let-7c-5p NRAS -0.503482361446512 0.206848395212976 0.606733058105388 0.0107700909176788 miRNAWalker2_validate;miRTarBase;MirTarget -0.124225168269858 0.00351586115791848 NA NA NA hsa-miR-145-5p NRAS -1.75133578902314 1.54965572197748e-05 0.606733058105388 0.0107700909176788 miRNAWalker2_validate;MirTarget;miRNATAP -0.113590801226011 0.00562715254109734 26973415 miR-145 expression was significantly downregulated in colon cancer tissues with its expression in normal colonic tissues being 4-5-fold higher two sample t test P < 0.05 whereas N-ras expression showed the opposite trend colon cancer hsa-miR-26a-5p NRAS -0.384110714440647 0.0442498636014044 0.606733058105388 0.0107700909176788 mirMAP;miRNATAP -0.253407088765911 0.00536728320880026 26458859 MiR 26a enhances the sensitivity of gastric cancer cells to cisplatin by targeting NRAS and E2F2; Our results suggest that miR-26a can improve the sensitivity of GC cells to cisplatin-based chemotherapies through targeting NRAS and E2F2 and provide the first evidence of the potential utility of miR-26a as a sensitizer in chemotherapy for GC gastric cancer hsa-miR-28-5p NRAS -0.238617853755144 0.167318538669818 0.606733058105388 0.0107700909176788 MirTarget;PITA;miRanda;miRNATAP -0.309483366881585 0.00227879779800337 NA NA NA hsa-miR-29c-3p NRAS -1.62454036584589 5.38376515586029e-07 0.606733058105388 0.0107700909176788 miRNATAP -0.175997480071788 0.000530133170369644 NA NA NA hsa-miR-21-5p NTF3 1.75445050487988 2.41825549682022e-23 -1.62090037978398 0.0028979647870912 miRTarBase;miRNATAP -0.654434459929646 0.00114877436972271 NA NA NA hsa-miR-107 NTRK2 0.904627575346218 4.67936495073904e-05 0.129052700235785 0.904324328702051 PITA;miRanda -1.24910626177656 0.00024341170686849 NA NA NA hsa-miR-140-3p NTRK2 -0.296251775392129 0.127539826012144 0.129052700235785 0.904324328702051 PITA -1.43629375239255 0.000327819599110366 NA NA NA hsa-miR-148a-5p NTRK2 -0.69329616490858 0.0793012233740369 0.129052700235785 0.904324328702051 mirMAP -0.62690136997922 0.00111999270999755 NA NA NA hsa-miR-186-5p NTRK2 0.149964130725901 0.434709542998771 0.129052700235785 0.904324328702051 mirMAP -1.53387891250486 0.000154763882037282 NA NA NA hsa-miR-29a-5p NTRK2 0.585084040404152 0.023014129158495 0.129052700235785 0.904324328702051 mirMAP -1.1189889083857 0.000158182837179273 NA NA NA hsa-miR-30d-3p NTRK2 -0.545113326540761 0.0433733076874155 0.129052700235785 0.904324328702051 mirMAP -0.840024189446887 0.00314885294170295 NA NA NA hsa-miR-30d-5p NTRK2 -0.5492586056147 0.0140125082460125 0.129052700235785 0.904324328702051 mirMAP -1.08205944732444 0.00168936814844951 NA NA NA hsa-miR-326 NTRK2 -0.429748586406214 0.2629894124021 0.129052700235785 0.904324328702051 miRanda -1.0084031919731 2.97462223495207e-07 NA NA NA hsa-miR-330-5p NTRK2 0.488365986827708 0.0512207630808233 0.129052700235785 0.904324328702051 miRanda -1.10006559956903 0.000320304929154941 NA NA NA hsa-miR-335-5p NTRK2 1.59953351087307 5.56170899867314e-05 0.129052700235785 0.904324328702051 miRNAWalker2_validate -0.554413660240109 0.00332406257269656 NA NA NA hsa-miR-338-3p NTRK2 -0.959276231066179 0.0191473351014091 0.129052700235785 0.904324328702051 miRanda -1.15537671088924 7.88265095662026e-11 NA NA NA hsa-miR-362-5p NTRK2 -0.354508685915981 0.354912078595613 0.129052700235785 0.904324328702051 mirMAP -0.973937329266648 6.24360566263495e-07 NA NA NA hsa-miR-501-5p NTRK2 0.266919328110625 0.454779001968586 0.129052700235785 0.904324328702051 mirMAP -1.02102960533135 1.21803450026443e-06 NA NA NA hsa-miR-532-5p NTRK2 0.313080805824184 0.252248939356301 0.129052700235785 0.904324328702051 PITA -1.59975014566445 4.3572070168858e-09 NA NA NA hsa-miR-577 NTRK2 0.911619788986754 0.2256062124148 0.129052700235785 0.904324328702051 mirMAP -0.449281370294781 1.07363179810198e-05 NA NA NA hsa-miR-139-5p PAK2 -1.83374360776637 1.22019901002824e-09 0.662056960095314 0.000235218579429093 MirTarget;miRanda -0.163967640643715 5.67597969950761e-05 NA NA NA hsa-miR-140-3p PAK2 -0.296251775392129 0.127539826012144 0.662056960095314 0.000235218579429093 MirTarget;PITA;miRNATAP -0.31081143169999 3.34260300865615e-06 NA NA NA hsa-miR-148a-5p PAK2 -0.69329616490858 0.0793012233740369 0.662056960095314 0.000235218579429093 MirTarget -0.108048782178219 0.000890424208827977 NA NA NA hsa-miR-26a-5p PAK2 -0.384110714440647 0.0442498636014044 0.662056960095314 0.000235218579429093 MirTarget;miRNATAP -0.273452376375985 6.54442373840941e-05 NA NA NA hsa-miR-149-5p PAK3 0.706277554734069 0.296848731347677 -3.5772039246138 4.54186204327769e-06 MirTarget;miRNATAP -0.382304033222635 3.51167172708527e-06 NA NA NA hsa-miR-17-5p PAK3 1.65862087862483 8.45603406215941e-08 -3.5772039246138 4.54186204327769e-06 TargetScan -0.520831054788933 0.00355061519388658 NA NA NA hsa-miR-18a-3p PAK3 2.35188582849667 1.39401350286321e-08 -3.5772039246138 4.54186204327769e-06 MirTarget;miRNATAP -0.358424923428214 0.00691956766213802 NA NA NA hsa-miR-23a-3p PAK3 1.10685926969665 3.16223452471768e-08 -3.5772039246138 4.54186204327769e-06 MirTarget -1.42235699228077 2.04683348546008e-07 NA NA NA hsa-miR-455-5p PAK3 1.20462751989145 6.74386011867484e-05 -3.5772039246138 4.54186204327769e-06 miRanda -0.549417202615278 0.003144028754319 NA NA NA hsa-miR-550a-3p PAK3 2.05849884025997 7.99642185793604e-07 -3.5772039246138 4.54186204327769e-06 MirTarget;miRNATAP -0.438167764947415 0.00282123173016703 NA NA NA hsa-miR-590-5p PAK3 1.04171442093217 0.000272475544954865 -3.5772039246138 4.54186204327769e-06 miRanda -0.711562553174732 0.000289988790533213 NA NA NA hsa-miR-96-5p PAK3 1.14243043653372 0.00942969392739105 -3.5772039246138 4.54186204327769e-06 TargetScan -0.517200005394476 0.00010938277609317 NA NA NA hsa-miR-145-5p PAK4 -1.75133578902314 1.54965572197748e-05 0.383518902716018 0.0187053978022324 miRNAWalker2_validate;miRTarBase -0.143431830079284 1.35779185227836e-07 23499891 We further demonstrated that miR-145 directly targeted catenin δ-1 contributing to the aberrant translocation of β-catenin through impaired nuclear shuttling with p21-activated kinase 4 PAK4 colon cancer hsa-miR-192-5p PAK6 0.0809146624034405 0.941057093528709 0.892188731608261 0.0236657400291424 miRNAWalker2_validate -0.150614524363184 1.11304010358318e-09 NA NA NA hsa-miR-215-5p PAK6 0.715250240418615 0.573784317311889 0.892188731608261 0.0236657400291424 miRNAWalker2_validate -0.126180690313495 3.23671316679885e-09 NA NA NA hsa-miR-361-3p PAK6 -0.126462931388735 0.566052688733137 0.892188731608261 0.0236657400291424 PITA -0.481679788168265 0.000198139838966242 NA NA NA hsa-miR-423-5p PAK6 0.832613878736338 0.000791321227103338 0.892188731608261 0.0236657400291424 miRNATAP -0.383244829760094 0.000700279854717888 NA NA NA hsa-miR-502-5p PAK6 -0.260297419808178 0.520453580478988 0.892188731608261 0.0236657400291424 PITA;miRNATAP -0.225637502894475 0.00128199528228843 NA NA NA hsa-miR-142-5p PDGFC 1.55592486377018 6.69269968016779e-06 -0.428293827442733 0.270026432499587 PITA -0.236484087228797 0.00247789392813088 NA NA NA hsa-miR-16-2-3p PDGFC 1.8048179609245 2.83095715136409e-09 -0.428293827442733 0.270026432499587 mirMAP -0.232746401733619 0.00795227840193951 NA NA NA hsa-miR-330-3p PDGFC 0.798460296022179 0.00746538156533435 -0.428293827442733 0.270026432499587 mirMAP -0.247895978465434 0.00739243902040488 NA NA NA hsa-miR-335-3p PDGFC 2.5197689063267 2.20084506976733e-09 -0.428293827442733 0.270026432499587 mirMAP -0.302703493361235 8.49467442588613e-07 NA NA NA hsa-miR-338-5p PDGFC -1.19659203838734 0.0100316010080496 -0.428293827442733 0.270026432499587 PITA;mirMAP -0.169288808465861 0.0040704717189607 NA NA NA hsa-miR-375 PDGFC -2.94506033785642 0.00570147601654791 -0.428293827442733 0.270026432499587 miRNAWalker2_validate;miRanda -0.112311266377289 8.21945774612344e-06 NA NA NA hsa-miR-7-1-3p PDGFC 0.709309110750947 0.0412301737463194 -0.428293827442733 0.270026432499587 mirMAP -0.363138642084197 3.27858616400315e-06 NA NA NA hsa-miR-7-5p PDGFC 1.63575693499363 0.0124424214624534 -0.428293827442733 0.270026432499587 miRNAWalker2_validate -0.125146317265827 0.00428044087803375 NA NA NA hsa-miR-125a-3p PDGFD 1.19506542853853 0.00164364545717311 -2.39203189150505 1.46051478070069e-07 miRanda -0.253230959321392 0.00412925400508089 NA NA NA hsa-miR-203a-3p PDGFD 1.44736908507496 0.0394116388736904 -2.39203189150505 1.46051478070069e-07 MirTarget -0.316546426347305 1.65912418696073e-12 NA NA NA hsa-miR-21-5p PDGFD 1.75445050487988 2.41825549682022e-23 -2.39203189150505 1.46051478070069e-07 miRNAWalker2_validate -0.491608165328088 0.00444359752142511 NA NA NA hsa-miR-331-5p PDGFD 1.0778596491846 2.79470024753813e-05 -2.39203189150505 1.46051478070069e-07 MirTarget -0.396625771818996 0.00204623350374034 NA NA NA hsa-miR-335-3p PDGFD 2.5197689063267 2.20084506976733e-09 -2.39203189150505 1.46051478070069e-07 mirMAP -0.207387134505796 0.00647284271479664 NA NA NA hsa-miR-590-5p PDGFD 1.04171442093217 0.000272475544954865 -2.39203189150505 1.46051478070069e-07 miRanda -0.404193042372488 0.000465242063829015 NA NA NA hsa-miR-944 PDGFD 3.33123095809751 0.0177835044930391 -2.39203189150505 1.46051478070069e-07 MirTarget;mirMAP -0.203792684451537 8.867679349447e-15 NA NA NA hsa-let-7a-3p PDGFRA 0.503048155002889 0.0411145454335299 -1.16052455489929 0.00469457800041433 mirMAP -0.408353851698219 0.000676900473184116 NA NA NA hsa-let-7b-3p PDGFRA 0.21838629112113 0.296038413622566 -1.16052455489929 0.00469457800041433 mirMAP -0.396878610010639 0.00585973151537375 NA NA NA hsa-let-7b-5p PDGFRA 0.0582902155815681 0.781400138984745 -1.16052455489929 0.00469457800041433 miRNAWalker2_validate -0.476383510169118 0.000849680543371195 NA NA NA hsa-let-7f-1-3p PDGFRA 1.28704406797397 1.17954701106157e-06 -1.16052455489929 0.00469457800041433 mirMAP -0.510677857296601 1.86478326712873e-06 NA NA NA hsa-let-7g-3p PDGFRA 0.64979533805273 0.0103084600883006 -1.16052455489929 0.00469457800041433 MirTarget;miRNATAP -0.427053544147745 0.000232980860387631 NA NA NA hsa-miR-106b-5p PDGFRA 1.70863907461894 2.04074794107142e-08 -1.16052455489929 0.00469457800041433 MirTarget;miRNATAP -0.309529989101084 0.000900259038001664 NA NA NA hsa-miR-130b-3p PDGFRA 1.32714007211004 4.78676252285191e-05 -1.16052455489929 0.00469457800041433 MirTarget;miRNATAP -0.323034116833204 0.000252646518119505 NA NA NA hsa-miR-141-3p PDGFRA 1.45548825076434 0.00115958850961764 -1.16052455489929 0.00469457800041433 MirTarget -0.272935688822065 2.05225184731917e-05 NA NA NA hsa-miR-149-5p PDGFRA 0.706277554734069 0.296848731347677 -1.16052455489929 0.00469457800041433 MirTarget;miRNATAP -0.204884142254506 1.43284462144315e-06 NA NA NA hsa-miR-16-1-3p PDGFRA 1.43227522002564 3.70920454953168e-08 -1.16052455489929 0.00469457800041433 MirTarget -0.386511551403792 0.000421130307898712 NA NA NA hsa-miR-17-5p PDGFRA 1.65862087862483 8.45603406215941e-08 -1.16052455489929 0.00469457800041433 MirTarget;TargetScan;miRNATAP -0.356393358462224 9.88240800111174e-05 NA NA NA hsa-miR-182-5p PDGFRA 0.887369486030646 0.0310640781418789 -1.16052455489929 0.00469457800041433 miRNATAP -0.360773153367445 2.16793167252092e-07 NA NA NA hsa-miR-196a-5p PDGFRA 6.59255881689547 1.53691144193899e-22 -1.16052455489929 0.00469457800041433 MirTarget;miRNATAP -0.111949684332786 0.00385048520276526 NA NA NA hsa-miR-196b-5p PDGFRA 5.58954708296963 1.12099152907987e-19 -1.16052455489929 0.00469457800041433 MirTarget;miRNATAP -0.130835032420459 0.00238656958843899 NA NA NA hsa-miR-20a-5p PDGFRA 1.4503375861709 5.7813456424762e-07 -1.16052455489929 0.00469457800041433 MirTarget;miRNATAP -0.290949630098886 0.00333304913306046 NA NA NA hsa-miR-219a-5p PDGFRA 0.605535434887599 0.0854495887591817 -1.16052455489929 0.00469457800041433 MirTarget -0.334702476451174 5.59649998290824e-05 NA NA NA hsa-miR-224-5p PDGFRA 2.7648036144402 0.000111736336240167 -1.16052455489929 0.00469457800041433 MirTarget -0.202264857356356 2.7344531322204e-07 NA NA NA hsa-miR-24-3p PDGFRA 1.08578167539644 6.18549359075268e-07 -1.16052455489929 0.00469457800041433 MirTarget;miRNATAP -0.80542708487755 3.49721401699797e-10 NA NA NA hsa-miR-27a-3p PDGFRA 1.29886998470345 2.68986118553486e-08 -1.16052455489929 0.00469457800041433 MirTarget;miRNATAP -0.749473123725816 2.3288170404456e-10 NA NA NA hsa-miR-27b-3p PDGFRA 0.0836323965901755 0.725273923274 -1.16052455489929 0.00469457800041433 MirTarget;miRNATAP -0.502143905481073 5.44941103065583e-05 NA NA NA hsa-miR-301a-3p PDGFRA 1.44721900431161 6.35068481036652e-06 -1.16052455489929 0.00469457800041433 MirTarget;miRNATAP -0.240717213465514 0.00761366951584292 NA NA NA hsa-miR-3065-5p PDGFRA -0.241623656423063 0.633116553078159 -1.16052455489929 0.00469457800041433 mirMAP -0.154613330078393 0.00962944858215771 NA NA NA hsa-miR-330-5p PDGFRA 0.488365986827708 0.0512207630808233 -1.16052455489929 0.00469457800041433 miRanda -0.311345692720835 0.00879331340845444 NA NA NA hsa-miR-335-3p PDGFRA 2.5197689063267 2.20084506976733e-09 -1.16052455489929 0.00469457800041433 mirMAP -0.180474779188923 0.00708107448376463 NA NA NA hsa-miR-33a-5p PDGFRA 0.407757858040717 0.321429014317207 -1.16052455489929 0.00469457800041433 MirTarget;miRNATAP -0.38674069592567 2.76867912009244e-08 NA NA NA hsa-miR-33b-5p PDGFRA 0.267227362818466 0.614814331176942 -1.16052455489929 0.00469457800041433 MirTarget;miRNATAP -0.330006551788421 2.87405240493235e-06 NA NA NA hsa-miR-34c-5p PDGFRA 2.20632574870337 0.000379662996168678 -1.16052455489929 0.00469457800041433 MirTarget;PITA;miRanda;miRNATAP -0.121772445130468 0.00965103598609489 NA NA NA hsa-miR-590-5p PDGFRA 1.04171442093217 0.000272475544954865 -1.16052455489929 0.00469457800041433 miRanda -0.480670069602324 1.60944318294763e-06 NA NA NA hsa-miR-93-5p PDGFRA 1.7515174434778 1.59386482413883e-08 -1.16052455489929 0.00469457800041433 MirTarget;miRNATAP -0.257971477859351 0.00500909640090511 NA NA NA hsa-miR-944 PDGFRA 3.33123095809751 0.0177835044930391 -1.16052455489929 0.00469457800041433 mirMAP -0.137440077961584 9.05523929015606e-09 NA NA NA hsa-miR-96-5p PDGFRA 1.14243043653372 0.00942969392739105 -1.16052455489929 0.00469457800041433 TargetScan;miRNATAP -0.367778743049386 5.89709579941633e-08 NA NA NA hsa-miR-3127-5p PDGFRB 0.98677589413294 0.00734249049849 0.844690963059587 0.0248980975397874 mirMAP -0.216339467888686 0.00297551716216838 NA NA NA hsa-miR-664a-3p PDGFRB -0.83041219170254 0.000136267547251167 0.844690963059587 0.0248980975397874 MirTarget -0.351564932871264 0.00450301463469565 NA NA NA hsa-miR-326 PGF -0.429748586406214 0.2629894124021 2.28861179569536 2.11563176368074e-07 mirMAP -0.24624077215828 0.00397086059498227 NA NA NA hsa-miR-335-5p PGF 1.59953351087307 5.56170899867314e-05 2.28861179569536 2.11563176368074e-07 miRNATAP -0.282601191101352 0.000396116789925528 NA NA NA hsa-miR-429 PGF 1.40182602301928 0.00900426780286475 2.28861179569536 2.11563176368074e-07 miRNATAP -0.171535690837198 0.00414084556636762 NA NA NA hsa-miR-126-5p PIK3CA 0.41765430251855 0.0753161203651532 0.181162005416898 0.379919524282219 mirMAP -0.230165325454576 0.000229328041159233 NA NA NA hsa-miR-146a-5p PIK3CA 1.82051649415508 2.03651725047679e-05 0.181162005416898 0.379919524282219 mirMAP -0.130514283326015 8.03472410512393e-05 NA NA NA hsa-miR-148a-5p PIK3CA -0.69329616490858 0.0793012233740369 0.181162005416898 0.379919524282219 mirMAP -0.160710142606256 9.74691916818117e-06 NA NA NA hsa-miR-148b-3p PIK3CA 0.295175884456199 0.17466422420702 0.181162005416898 0.379919524282219 miRNAWalker2_validate -0.270665697414514 6.25461929338548e-05 NA NA NA hsa-miR-186-5p PIK3CA 0.149964130725901 0.434709542998771 0.181162005416898 0.379919524282219 mirMAP -0.283664174467296 0.000254482000083255 NA NA NA hsa-miR-29b-1-5p PIK3CA 0.606560155953522 0.116355599574769 0.181162005416898 0.379919524282219 mirMAP -0.105962073023743 0.00514891759991948 NA NA NA hsa-miR-320b PIK3CA 1.11183660885284 0.000497971211648503 0.181162005416898 0.379919524282219 miRanda -0.131928082159166 0.00355606170878243 NA NA NA hsa-miR-335-5p PIK3CA 1.59953351087307 5.56170899867314e-05 0.181162005416898 0.379919524282219 miRNAWalker2_validate -0.142668444274705 6.55217134166698e-05 NA NA NA hsa-miR-338-5p PIK3CA -1.19659203838734 0.0100316010080496 0.181162005416898 0.379919524282219 mirMAP -0.128160056012068 3.12181075963217e-05 NA NA NA hsa-miR-501-5p PIK3CA 0.266919328110625 0.454779001968586 0.181162005416898 0.379919524282219 mirMAP -0.184484665922465 4.78508048904086e-06 NA NA NA hsa-miR-7-1-3p PIK3CA 0.709309110750947 0.0412301737463194 0.181162005416898 0.379919524282219 mirMAP -0.18347710340594 9.07765701687707e-06 NA NA NA hsa-miR-130a-3p PIK3CB 0.146223920674657 0.633739795905839 0.248944033508746 0.180378115579181 miRNATAP -0.141347568269357 0.0010035949231668 NA NA NA hsa-miR-1468-5p PIK3CD -1.88350218312373 3.31332405201189e-05 0.391814669139483 0.253077445924908 MirTarget -0.217696918010317 3.06934786857079e-05 NA NA NA hsa-miR-30b-3p PIK3CD -0.266398938200332 0.400847813143994 0.391814669139483 0.253077445924908 MirTarget -0.431008741394064 8.57729594514163e-09 NA NA NA hsa-miR-30b-5p PIK3CD -0.430720743745757 0.0593564057320791 0.391814669139483 0.253077445924908 MirTarget -0.481822586915696 5.93876910377637e-06 NA NA NA hsa-miR-30d-5p PIK3CD -0.5492586056147 0.0140125082460125 0.391814669139483 0.253077445924908 MirTarget;miRNATAP -0.669349357920634 2.53796175626459e-10 NA NA NA hsa-miR-616-5p PIK3CD 0.834052908652744 0.0347835664029363 0.391814669139483 0.253077445924908 MirTarget -0.171408745877689 0.0062816347712319 NA NA NA hsa-miR-7-5p PIK3CD 1.63575693499363 0.0124424214624534 0.391814669139483 0.253077445924908 miRTarBase;MirTarget;miRNATAP -0.205801781586893 4.40558507915807e-08 22234835 We first screened and identified a novel miR-7 target phosphoinositide 3-kinase catalytic subunit delta PIK3CD; A correlation between miR-7 and PIK3CD expression was also confirmed in clinical samples of HCC; By targeting PIK3CD mTOR and p70S6K miR-7 efficiently regulates the PI3K/Akt pathway liver cancer hsa-miR-103a-3p PIK3R1 0.840525139266028 5.83536475789158e-07 -1.09428616452248 2.46783518047221e-05 MirTarget;miRNATAP -0.323457232113071 0.0039447769693221 NA NA NA hsa-miR-106b-5p PIK3R1 1.70863907461894 2.04074794107142e-08 -1.09428616452248 2.46783518047221e-05 MirTarget;miRNATAP -0.253346436583178 1.72729352701852e-05 NA NA NA hsa-miR-107 PIK3R1 0.904627575346218 4.67936495073904e-05 -1.09428616452248 2.46783518047221e-05 MirTarget;PITA;miRanda;miRNATAP -0.238654922729134 0.0046938788179217 NA NA NA hsa-miR-128-3p PIK3R1 0.98280381420517 5.77641850797209e-05 -1.09428616452248 2.46783518047221e-05 MirTarget -0.253825409257793 0.000861541031670611 25962360 miR 128 3p suppresses hepatocellular carcinoma proliferation by regulating PIK3R1 and is correlated with the prognosis of HCC patients; Mechanistically miR-128-3p was confirmed to regulate PIK3R1 p85α expression thereby suppressing phosphatidylinositol 3-kinase PI3K/AKT pathway activation using qRT-PCR and western blot analysis; Hence we conclude that miR-128-3p which is frequently downregulated in HCC inhibits HCC progression by regulating PIK3R1 and PI3K/AKT activation and is a prognostic marker for HCC patients worse prognosis;progression liver cancer hsa-miR-144-3p PIK3R1 -0.13309578176575 0.798245647923351 -1.09428616452248 2.46783518047221e-05 mirMAP -0.138673461850839 0.000126186382128809 NA NA NA hsa-miR-15b-5p PIK3R1 1.62046407540723 5.42152621571078e-09 -1.09428616452248 2.46783518047221e-05 MirTarget -0.323211150072369 4.46298725379362e-07 NA NA NA hsa-miR-16-2-3p PIK3R1 1.8048179609245 2.83095715136409e-09 -1.09428616452248 2.46783518047221e-05 MirTarget -0.270383492169966 3.99207467881518e-06 NA NA NA hsa-miR-16-5p PIK3R1 1.00515772948091 5.33912942007619e-06 -1.09428616452248 2.46783518047221e-05 MirTarget -0.405416526556489 9.69480909855754e-07 NA NA NA hsa-miR-17-5p PIK3R1 1.65862087862483 8.45603406215941e-08 -1.09428616452248 2.46783518047221e-05 MirTarget;TargetScan;miRNATAP -0.192199170444737 0.00107429271534319 NA NA NA hsa-miR-182-5p PIK3R1 0.887369486030646 0.0310640781418789 -1.09428616452248 2.46783518047221e-05 miRNATAP -0.160218491940506 0.000398426335382569 NA NA NA hsa-miR-185-5p PIK3R1 1.14351510556643 1.07346945085714e-08 -1.09428616452248 2.46783518047221e-05 miRNATAP -0.41775889137189 4.21636400438791e-06 NA NA NA hsa-miR-188-5p PIK3R1 1.35426907033843 0.00038346077691455 -1.09428616452248 2.46783518047221e-05 MirTarget -0.162900447887926 0.000775923703794411 NA NA NA hsa-miR-200b-3p PIK3R1 0.974577911407732 0.0595020056914543 -1.09428616452248 2.46783518047221e-05 mirMAP -0.103803538669649 0.00409847558383849 NA NA NA hsa-miR-200c-3p PIK3R1 1.28185685499076 0.00369777635539177 -1.09428616452248 2.46783518047221e-05 mirMAP -0.143316221972735 0.00063899158230993 NA NA NA hsa-miR-20a-5p PIK3R1 1.4503375861709 5.7813456424762e-07 -1.09428616452248 2.46783518047221e-05 MirTarget;miRNATAP -0.175478538743826 0.0056099063555159 NA NA NA hsa-miR-21-5p PIK3R1 1.75445050487988 2.41825549682022e-23 -1.09428616452248 2.46783518047221e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.306402457018565 0.00154965993784699 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-212-3p PIK3R1 0.960352937108106 0.00133449812322732 -1.09428616452248 2.46783518047221e-05 MirTarget -0.22956448368642 0.000224776230276284 NA NA NA hsa-miR-22-5p PIK3R1 0.804348748654247 0.000804065112767412 -1.09428616452248 2.46783518047221e-05 mirMAP -0.271562984507077 0.000499671844853285 NA NA NA hsa-miR-221-3p PIK3R1 1.33496247538338 3.82022531235275e-07 -1.09428616452248 2.46783518047221e-05 MirTarget -0.313499877783358 5.35467630228685e-06 NA NA NA hsa-miR-222-3p PIK3R1 1.39382731585819 9.98182478024671e-07 -1.09428616452248 2.46783518047221e-05 MirTarget -0.284754511073413 7.61572703183408e-06 NA NA NA hsa-miR-3065-5p PIK3R1 -0.241623656423063 0.633116553078159 -1.09428616452248 2.46783518047221e-05 MirTarget;mirMAP;miRNATAP -0.124182539774803 0.00105993614946939 NA NA NA hsa-miR-32-3p PIK3R1 0.583525764322974 0.11837203008551 -1.09428616452248 2.46783518047221e-05 mirMAP -0.17265888879632 0.00228085828010069 NA NA NA hsa-miR-320b PIK3R1 1.11183660885284 0.000497971211648503 -1.09428616452248 2.46783518047221e-05 miRNATAP -0.162259703959997 0.00544641812773208 NA NA NA hsa-miR-324-3p PIK3R1 1.04940352369965 0.000387716796520961 -1.09428616452248 2.46783518047221e-05 MirTarget;PITA;miRNATAP -0.184232658949902 0.00347746569584922 NA NA NA hsa-miR-330-3p PIK3R1 0.798460296022179 0.00746538156533435 -1.09428616452248 2.46783518047221e-05 MirTarget;PITA;miRNATAP -0.26440540068663 2.08637052595379e-05 NA NA NA hsa-miR-335-3p PIK3R1 2.5197689063267 2.20084506976733e-09 -1.09428616452248 2.46783518047221e-05 mirMAP -0.148076206465714 0.000495756694433814 NA NA NA hsa-miR-424-5p PIK3R1 1.08509868581983 0.000420473853818268 -1.09428616452248 2.46783518047221e-05 MirTarget -0.287369315123124 1.32105570633977e-06 NA NA NA hsa-miR-429 PIK3R1 1.40182602301928 0.00900426780286475 -1.09428616452248 2.46783518047221e-05 mirMAP;miRNATAP -0.126994249956039 0.00022771493817442 NA NA NA hsa-miR-455-3p PIK3R1 2.29532323519288 1.85675588946527e-07 -1.09428616452248 2.46783518047221e-05 MirTarget;PITA;miRNATAP -0.181586331748295 8.05157474846207e-06 NA NA NA hsa-miR-542-3p PIK3R1 0.757649022262991 0.00210575463285599 -1.09428616452248 2.46783518047221e-05 MirTarget;PITA;miRanda -0.239065351988831 0.0017318237826115 NA NA NA hsa-miR-584-5p PIK3R1 1.68234626630933 0.000166828539264215 -1.09428616452248 2.46783518047221e-05 mirMAP -0.129450210806705 0.00170622715972499 NA NA NA hsa-miR-590-3p PIK3R1 1.11654983899947 0.000160782154924864 -1.09428616452248 2.46783518047221e-05 miRanda;mirMAP -0.266046553887174 1.8351581859886e-05 NA NA NA hsa-miR-590-5p PIK3R1 1.04171442093217 0.000272475544954865 -1.09428616452248 2.46783518047221e-05 MirTarget;PITA;miRanda;miRNATAP -0.297910761408884 3.33366270664506e-06 NA NA NA hsa-miR-629-3p PIK3R1 1.40326397107309 9.7803063526732e-05 -1.09428616452248 2.46783518047221e-05 MirTarget -0.16619442916244 0.00118253063445621 NA NA NA hsa-miR-96-5p PIK3R1 1.14243043653372 0.00942969392739105 -1.09428616452248 2.46783518047221e-05 TargetScan;miRNATAP -0.193630203103858 1.00718533638407e-05 NA NA NA hsa-miR-30a-5p PIK3R2 -1.71922855140016 3.20574349285256e-07 0.00922907299312037 0.961081205853821 miRNATAP -0.137164224996737 0.000346855164996688 NA NA NA hsa-miR-1271-5p PIK3R3 1.15538250415776 0.00207865862606828 -0.662491536689023 0.0210304127874503 mirMAP -0.197799197361284 0.00028487328401707 NA NA NA hsa-miR-185-3p PIK3R3 1.33711019171256 3.45756583967985e-05 -0.662491536689023 0.0210304127874503 MirTarget -0.200301326896551 0.00130353125166929 NA NA NA hsa-miR-511-5p PIK3R3 0.542335183701817 0.127507740178883 -0.662491536689023 0.0210304127874503 MirTarget -0.231823970894027 4.82261601939889e-05 25608840 MiR 511 inhibits growth and metastasis of human hepatocellular carcinoma cells by targeting PIK3R3; We further demonstrated that miR-511 suppressed HCC cell proliferation migration and invasion by repressing PIK3R3 expression metastasis liver cancer hsa-miR-708-3p PIK3R3 0.623782703831307 0.275355868302311 -0.662491536689023 0.0210304127874503 mirMAP -0.147502347303041 2.93933869168246e-05 NA NA NA hsa-miR-324-5p PLA1A 1.08820215809537 3.11674414561836e-05 -1.12628452737285 0.132487064803426 miRanda -0.794658910908154 7.27304626602664e-05 NA NA NA hsa-miR-34c-5p PLA1A 2.20632574870337 0.000379662996168678 -1.12628452737285 0.132487064803426 miRanda -0.333543955848445 7.6280284858729e-05 NA NA NA hsa-miR-142-5p PLA2G12A 1.55592486377018 6.69269968016779e-06 -0.897976387208921 3.92439583608381e-08 mirMAP -0.120071229648663 0.000364039582551817 NA NA NA hsa-miR-16-2-3p PLA2G12A 1.8048179609245 2.83095715136409e-09 -0.897976387208921 3.92439583608381e-08 mirMAP -0.13547544045603 0.000324052648114578 NA NA NA hsa-miR-590-5p PLA2G16 1.04171442093217 0.000272475544954865 -0.579787707693295 0.375547187280192 miRanda -0.446911509158929 0.00567242644103029 NA NA NA hsa-let-7g-5p PLA2G3 0.325297685027927 0.241142963826631 1.08081143630036 0.274800614063828 MirTarget -0.713843300957369 0.00535751699457478 NA NA NA hsa-miR-338-3p PLA2G3 -0.959276231066179 0.0191473351014091 1.08081143630036 0.274800614063828 MirTarget;miRanda;miRNATAP -0.599759722990571 0.000430611134352631 NA NA NA hsa-miR-592 PLA2G3 0.779567202789068 0.204498177014474 1.08081143630036 0.274800614063828 miRNATAP -0.323513783396214 0.00859092346414437 NA NA NA hsa-miR-107 PLA2G4C 0.904627575346218 4.67936495073904e-05 0.138524831959384 0.754694006784229 miRanda -0.454324859178965 0.0012694320270798 NA NA NA hsa-miR-125a-5p PLA2G4D -0.878090699011564 0.000213630844319685 1.66089069635294 0.0288589229883454 miRanda -0.638036065706876 0.00532621131340778 NA NA NA hsa-miR-125a-5p PLA2G4F -0.878090699011564 0.000213630844319685 0.472077464612536 0.552111161085773 miRNAWalker2_validate -0.946523228478928 5.75069795471914e-05 NA NA NA hsa-miR-125b-5p PLA2G4F -0.509303501421334 0.133265526313161 0.472077464612536 0.552111161085773 miRNAWalker2_validate -0.780649880110642 1.88119091837135e-06 NA NA NA hsa-miR-99b-5p PLA2G4F -0.13479816934921 0.559985680534109 0.472077464612536 0.552111161085773 miRNAWalker2_validate -1.03099025098046 2.65018980739127e-05 NA NA NA hsa-miR-128-3p PLA2G5 0.98280381420517 5.77641850797209e-05 -1.41308234162024 0.0225473078256035 miRNAWalker2_validate -0.905295305603834 2.75117618540628e-07 NA NA NA hsa-miR-330-5p PLA2G5 0.488365986827708 0.0512207630808233 -1.41308234162024 0.0225473078256035 miRanda -0.926413267320503 1.02011927893847e-07 NA NA NA hsa-miR-339-5p PLA2G5 0.770566566962108 0.00816529093411862 -1.41308234162024 0.0225473078256035 miRanda -0.723615809585887 1.23466479069586e-06 NA NA NA hsa-miR-429 PLA2G5 1.40182602301928 0.00900426780286475 -1.41308234162024 0.0225473078256035 miRanda -0.548400833208393 1.57333799329149e-12 NA NA NA hsa-miR-589-3p PLA2G5 1.01962606923682 0.00577853347252709 -1.41308234162024 0.0225473078256035 MirTarget -0.574409018016161 8.84241947286267e-07 NA NA NA hsa-miR-590-3p PLA2G5 1.11654983899947 0.000160782154924864 -1.41308234162024 0.0225473078256035 miRanda;miRNATAP -0.733311626897206 4.33156195650278e-07 NA NA NA hsa-miR-590-5p PLA2G5 1.04171442093217 0.000272475544954865 -1.41308234162024 0.0225473078256035 miRanda -0.821191810458237 3.9237270066779e-08 NA NA NA hsa-miR-125a-3p PLCE1 1.19506542853853 0.00164364545717311 -1.90518814307026 0.000304223689205431 miRanda -0.281886717464537 0.00506734360735283 NA NA NA hsa-miR-199a-5p PLCE1 0.371973504507027 0.232661597228763 -1.90518814307026 0.000304223689205431 miRanda -0.467237139786278 0.000127196324377981 NA NA NA hsa-miR-455-5p PLCE1 1.20462751989145 6.74386011867484e-05 -1.90518814307026 0.000304223689205431 miRanda -0.597403760003157 9.81949795892708e-07 NA NA NA hsa-miR-96-5p PLCE1 1.14243043653372 0.00942969392739105 -1.90518814307026 0.000304223689205431 TargetScan -0.332210962175092 0.00020793740304237 NA NA NA hsa-miR-200b-3p PLCG1 0.974577911407732 0.0595020056914543 0.220650145027044 0.240784739884018 TargetScan -0.152523804697572 5.66449876796049e-10 NA NA NA hsa-miR-3065-3p PLCG1 -1.03551124329864 0.0218397494946288 0.220650145027044 0.240784739884018 miRNATAP -0.103906981778707 0.000353878093657446 NA NA NA hsa-miR-429 PLCG1 1.40182602301928 0.00900426780286475 0.220650145027044 0.240784739884018 PITA;miRanda;miRNATAP -0.140203562615716 3.32118673073251e-09 NA NA NA hsa-miR-582-5p PLCG1 -0.448820171762719 0.134615974001015 0.220650145027044 0.240784739884018 PITA;miRNATAP -0.144938357620992 0.00109688062783437 NA NA NA hsa-miR-335-5p PLCG2 1.59953351087307 5.56170899867314e-05 0.0457293991289704 0.881449349859118 miRNAWalker2_validate -0.148683931134901 0.00575362635056513 NA NA NA hsa-miR-107 PLD1 0.904627575346218 4.67936495073904e-05 0.429078777688086 0.133338361694059 MirTarget;miRanda -0.363825479129327 5.56716658003527e-05 NA NA NA hsa-miR-326 PLD1 -0.429748586406214 0.2629894124021 0.429078777688086 0.133338361694059 miRanda -0.235485403882764 8.147028779188e-06 NA NA NA hsa-miR-500a-5p PLD1 0.00337014556047865 0.992120109131868 0.429078777688086 0.133338361694059 MirTarget -0.294131699024164 5.09435208659553e-07 NA NA NA hsa-miR-577 PLD1 0.911619788986754 0.2256062124148 0.429078777688086 0.133338361694059 MirTarget -0.113109383802382 3.27914339876289e-05 NA NA NA hsa-miR-326 PLD2 -0.429748586406214 0.2629894124021 0.356053306521978 0.188822066327453 miRanda -0.134028021669118 0.00835259639872871 NA NA NA hsa-miR-625-5p PRKACA 0.537211086526376 0.203801009380384 -0.0978746557285595 0.44498806360937 MirTarget -0.131652673177358 1.09755795457608e-10 NA NA NA hsa-let-7f-1-3p PRKACB 1.28704406797397 1.17954701106157e-06 -2.00320334289066 3.9598668244402e-09 MirTarget;mirMAP -0.314793266126612 0.000724594726922014 NA NA NA hsa-miR-141-3p PRKACB 1.45548825076434 0.00115958850961764 -2.00320334289066 3.9598668244402e-09 MirTarget;TargetScan;miRNATAP -0.197564834301336 0.000353082319368401 NA NA NA hsa-miR-146b-5p PRKACB 1.547491371264 6.06614361290688e-08 -2.00320334289066 3.9598668244402e-09 miRanda -0.225282836158709 0.00882894958009726 NA NA NA hsa-miR-16-2-3p PRKACB 1.8048179609245 2.83095715136409e-09 -2.00320334289066 3.9598668244402e-09 mirMAP -0.306924849458949 0.000109522279734088 NA NA NA hsa-miR-17-5p PRKACB 1.65862087862483 8.45603406215941e-08 -2.00320334289066 3.9598668244402e-09 TargetScan -0.352359251315541 6.11316064096321e-06 NA NA NA hsa-miR-183-5p PRKACB 1.65900927871187 0.000522025364980187 -2.00320334289066 3.9598668244402e-09 MirTarget -0.181167666603194 0.000458522643446536 NA NA NA hsa-miR-18a-5p PRKACB 2.20211504140984 1.78678887916334e-09 -2.00320334289066 3.9598668244402e-09 miRNATAP -0.316335887919593 1.04839236101925e-06 NA NA NA hsa-miR-200c-3p PRKACB 1.28185685499076 0.00369777635539177 -2.00320334289066 3.9598668244402e-09 MirTarget;miRNATAP -0.207576946884606 0.000221208096678535 NA NA NA hsa-miR-2110 PRKACB 0.759864042760204 0.0723961390557655 -2.00320334289066 3.9598668244402e-09 MirTarget -0.183383468055812 0.00233810067736044 NA NA NA hsa-miR-330-3p PRKACB 0.798460296022179 0.00746538156533435 -2.00320334289066 3.9598668244402e-09 MirTarget -0.302274508758057 0.000317953568855911 NA NA NA hsa-miR-361-5p PRKACB 0.407725414130987 0.0181260969156347 -2.00320334289066 3.9598668244402e-09 miRanda -0.504068079086418 0.000769646776305189 NA NA NA hsa-miR-421 PRKACB 1.80720854070385 1.59709651202848e-07 -2.00320334289066 3.9598668244402e-09 PITA;miRanda -0.335137675315492 1.50625671113954e-06 NA NA NA hsa-miR-590-5p PRKACB 1.04171442093217 0.000272475544954865 -2.00320334289066 3.9598668244402e-09 miRanda -0.271769978727668 0.00186178178431082 NA NA NA hsa-miR-93-5p PRKACB 1.7515174434778 1.59386482413883e-08 -2.00320334289066 3.9598668244402e-09 miRNAWalker2_validate -0.293844505175028 0.000169582064126035 NA NA NA hsa-miR-96-5p PRKACB 1.14243043653372 0.00942969392739105 -2.00320334289066 3.9598668244402e-09 miRNATAP -0.170553493993393 0.00429769927359632 NA NA NA hsa-miR-183-5p PRKCA 1.65900927871187 0.000522025364980187 -0.524945602243661 0.156845722980603 miRNATAP -0.31103089433757 3.16968192454963e-09 NA NA NA hsa-miR-193b-3p PRKCA 0.281752012268679 0.451258902263119 -0.524945602243661 0.156845722980603 miRNAWalker2_validate -0.484019253003446 4.65153076194767e-13 NA NA NA hsa-miR-193b-5p PRKCA 0.609581100028941 0.13923921336815 -0.524945602243661 0.156845722980603 mirMAP -0.433727503937308 7.91160654871288e-13 NA NA NA hsa-miR-200c-3p PRKCA 1.28185685499076 0.00369777635539177 -0.524945602243661 0.156845722980603 miRNATAP -0.158267946470227 0.0075664310799573 NA NA NA hsa-miR-214-3p PRKCA 1.01201534142544 0.00625092909225755 -0.524945602243661 0.156845722980603 mirMAP -0.229516662046359 0.00116026469450838 NA NA NA hsa-miR-218-5p PRKCA -0.987730614742492 0.0108295837207062 -0.524945602243661 0.156845722980603 mirMAP -0.340197633280215 2.69227593052796e-07 NA NA NA hsa-miR-22-5p PRKCA 0.804348748654247 0.000804065112767412 -0.524945602243661 0.156845722980603 mirMAP -0.289814182834915 0.0085643888637562 NA NA NA hsa-miR-224-5p PRKCA 2.7648036144402 0.000111736336240167 -0.524945602243661 0.156845722980603 mirMAP -0.266077095767105 2.93934461700145e-15 NA NA NA hsa-miR-2355-3p PRKCA 0.982963823342009 0.0229275810851348 -0.524945602243661 0.156845722980603 mirMAP -0.192620283882863 0.00177074877059007 NA NA NA hsa-miR-24-2-5p PRKCA 1.24948624677556 6.95051249640114e-07 -0.524945602243661 0.156845722980603 miRNAWalker2_validate -0.44305928315788 1.26846671995315e-05 22911661 Preferential star strand biogenesis of pre miR 24 2 targets PKC alpha and suppresses cell survival in MCF 7 breast cancer cells poor survival breast cancer hsa-miR-3065-5p PRKCA -0.241623656423063 0.633116553078159 -0.524945602243661 0.156845722980603 mirMAP -0.138739209322651 0.00952332540419745 NA NA NA hsa-miR-30e-3p PRKCA -0.913131357083321 7.29096855615228e-06 -0.524945602243661 0.156845722980603 mirMAP -0.480631092157774 0.000179519199509064 NA NA NA hsa-miR-340-5p PRKCA -0.164941927483643 0.529910509321278 -0.524945602243661 0.156845722980603 mirMAP -0.30203863377261 0.00294907401860914 NA NA NA hsa-miR-369-3p PRKCA 0.32261175629684 0.3589927609891 -0.524945602243661 0.156845722980603 PITA;miRNATAP -0.329749662436249 8.7729830203155e-06 NA NA NA hsa-miR-374a-3p PRKCA 0.0420912023953779 0.851478041312794 -0.524945602243661 0.156845722980603 mirMAP -0.476867699823759 5.6043349916606e-05 NA NA NA hsa-miR-374a-5p PRKCA -0.116485410477589 0.554703396010082 -0.524945602243661 0.156845722980603 mirMAP -0.356017213117889 0.00964742858084568 NA NA NA hsa-miR-381-3p PRKCA -0.385137659444633 0.19550293487428 -0.524945602243661 0.156845722980603 mirMAP -0.251195477739459 0.00489691969707007 NA NA NA hsa-miR-452-5p PRKCA 2.08756506185889 0.000258095769002813 -0.524945602243661 0.156845722980603 mirMAP -0.362021740586027 3.81652270570704e-18 NA NA NA hsa-miR-485-3p PRKCA 0.402652239390796 0.291980476362068 -0.524945602243661 0.156845722980603 PITA -0.187072641608852 0.00755799449285324 NA NA NA hsa-miR-590-3p PRKCA 1.11654983899947 0.000160782154924864 -0.524945602243661 0.156845722980603 PITA;miRanda;mirMAP;miRNATAP -0.253263144251919 0.0041311394662334 NA NA NA hsa-miR-654-3p PRKCA -0.180620884059292 0.603937505298333 -0.524945602243661 0.156845722980603 mirMAP -0.244452048619274 0.00127970540235088 NA NA NA hsa-miR-9-3p PRKCA 0.330346058941473 0.541111939982661 -0.524945602243661 0.156845722980603 mirMAP -0.16554523182915 0.00109100333735947 NA NA NA hsa-miR-9-5p PRKCA -0.195328736653048 0.761470692992178 -0.524945602243661 0.156845722980603 miRNATAP -0.159066735795387 8.70395397790985e-05 NA NA NA hsa-miR-93-3p PRKCA 1.88964231421793 1.80075645722786e-08 -0.524945602243661 0.156845722980603 mirMAP -0.204378358847077 0.00717568024324572 NA NA NA hsa-miR-944 PRKCA 3.33123095809751 0.0177835044930391 -0.524945602243661 0.156845722980603 PITA;miRNATAP -0.18876945085729 3.75302733857894e-21 NA NA NA hsa-miR-141-5p PRKCB 2.07543489990205 6.42575039070838e-06 -1.4030462275744 0.00367216720425109 mirMAP -0.395737238483437 3.03734398729028e-08 NA NA NA hsa-miR-16-2-3p PRKCB 1.8048179609245 2.83095715136409e-09 -1.4030462275744 0.00367216720425109 mirMAP -0.394725287595774 0.000305348610545586 NA NA NA hsa-miR-200b-3p PRKCB 0.974577911407732 0.0595020056914543 -1.4030462275744 0.00367216720425109 MirTarget -0.282755939415459 1.75770095316849e-05 NA NA NA hsa-miR-200c-3p PRKCB 1.28185685499076 0.00369777635539177 -1.4030462275744 0.00367216720425109 MirTarget;miRNATAP -0.484133503530668 8.09834496190732e-11 NA NA NA hsa-miR-23a-3p PRKCB 1.10685926969665 3.16223452471768e-08 -1.4030462275744 0.00367216720425109 mirMAP -0.683926072101064 5.15520137880557e-05 NA NA NA hsa-miR-24-3p PRKCB 1.08578167539644 6.18549359075268e-07 -1.4030462275744 0.00367216720425109 miRNATAP -0.723177032098718 2.88589756557307e-06 NA NA NA hsa-miR-27a-3p PRKCB 1.29886998470345 2.68986118553486e-08 -1.4030462275744 0.00367216720425109 MirTarget;miRNATAP -0.51359480289477 0.000369553651535914 NA NA NA hsa-miR-335-3p PRKCB 2.5197689063267 2.20084506976733e-09 -1.4030462275744 0.00367216720425109 mirMAP -0.29799969660431 0.000138565873644795 NA NA NA hsa-miR-429 PRKCB 1.40182602301928 0.00900426780286475 -1.4030462275744 0.00367216720425109 MirTarget;miRanda;miRNATAP -0.304844311690637 1.18954411842667e-06 NA NA NA hsa-miR-452-3p PRKCB 2.2028815467959 0.00185370432491004 -1.4030462275744 0.00367216720425109 mirMAP -0.17651507962963 0.00117496673508882 NA NA NA hsa-miR-589-3p PRKCB 1.01962606923682 0.00577853347252709 -1.4030462275744 0.00367216720425109 mirMAP -0.261170452838673 0.00515336080055526 NA NA NA hsa-miR-589-5p PRKCB 0.702695092403762 0.00395772685954799 -1.4030462275744 0.00367216720425109 mirMAP -0.370279961813979 0.00967226035852969 NA NA NA hsa-miR-590-5p PRKCB 1.04171442093217 0.000272475544954865 -1.4030462275744 0.00367216720425109 miRanda -0.40560794652637 0.000708295993250929 NA NA NA hsa-miR-616-5p PRKCB 0.834052908652744 0.0347835664029363 -1.4030462275744 0.00367216720425109 mirMAP -0.374505698749983 2.12152566695212e-05 NA NA NA hsa-miR-9-3p PRKCB 0.330346058941473 0.541111939982661 -1.4030462275744 0.00367216720425109 mirMAP -0.172769921695024 0.00989297046602862 NA NA NA hsa-miR-2355-5p PRKCG 0.594869787574182 0.120591076715177 -0.106646796932468 0.91801459782895 MirTarget -0.976109502699328 1.98177589887047e-07 NA NA NA hsa-let-7b-3p PTPN11 0.21838629112113 0.296038413622566 -0.154790111247342 0.236179705145447 mirMAP -0.14630631158987 0.00102525420613718 NA NA NA hsa-miR-130a-3p RAB5A 0.146223920674657 0.633739795905839 -0.184087412188828 0.190217182510342 miRNAWalker2_validate;MirTarget;miRNATAP -0.131132984084042 4.24087242625049e-05 25755726 MicroRNA 130a inhibits cell proliferation invasion and migration in human breast cancer by targeting the RAB5A; With the bioinformatics analysis we further identified that RAB5A was a directly target of miR-130a and its mRNA and protein level was negatively regulated by miR-130a breast cancer hsa-miR-199a-5p RAB5A 0.371973504507027 0.232661597228763 -0.184087412188828 0.190217182510342 miRanda -0.121188334762365 0.000123142526480804 NA NA NA hsa-miR-199b-5p RAB5A 0.124595928096068 0.678156859366405 -0.184087412188828 0.190217182510342 miRanda -0.102698909533208 0.0018943896183941 NA NA NA hsa-miR-17-5p RAB5B 1.65862087862483 8.45603406215941e-08 -0.555961805115135 5.96767294499609e-05 miRNAWalker2_validate;TargetScan;miRNATAP -0.105541282382101 0.000643954678595603 NA NA NA hsa-miR-20a-5p RAB5B 1.4503375861709 5.7813456424762e-07 -0.555961805115135 5.96767294499609e-05 miRNATAP -0.118172255436658 0.000366706909510422 NA NA NA hsa-miR-301a-3p RAB5B 1.44721900431161 6.35068481036652e-06 -0.555961805115135 5.96767294499609e-05 miRNATAP -0.120371128762363 5.98061483369737e-05 NA NA NA hsa-miR-423-5p RAB5B 0.832613878736338 0.000791321227103338 -0.555961805115135 5.96767294499609e-05 miRNATAP -0.107260435112767 0.00727205312592257 NA NA NA hsa-miR-454-3p RAB5B 0.625199142970745 0.0134890997402741 -0.555961805115135 5.96767294499609e-05 miRNATAP -0.183872142443805 1.95234584593793e-06 NA NA NA hsa-miR-93-5p RAB5B 1.7515174434778 1.59386482413883e-08 -0.555961805115135 5.96767294499609e-05 miRNAWalker2_validate;miRNATAP -0.123122776493816 5.69837887704003e-05 NA NA NA hsa-miR-30c-5p RAC1 -0.983130268805942 4.60419218706127e-05 0.63005132289186 0.00013432252267484 miRNAWalker2_validate -0.215519718166738 7.09586530438521e-06 NA NA NA hsa-miR-375 RAC2 -2.94506033785642 0.00570147601654791 1.62151327855796 1.05038880277147e-05 miRanda -0.111436700267932 4.91783218198251e-06 NA NA NA hsa-miR-342-3p RAC3 0.318119432680668 0.269150960124243 0.309748967802459 0.467555115343412 miRanda -0.296741961155951 0.00517182849282247 NA NA NA hsa-miR-146b-3p RAF1 1.10138643500522 3.66835580263893e-05 -0.8632101633735 1.53817801108877e-10 MirTarget;PITA;miRNATAP -0.120516156621644 0.00105150756879764 NA NA NA hsa-miR-484 RAF1 0.71327898984355 0.00233605130771196 -0.8632101633735 1.53817801108877e-10 MirTarget -0.121560277635947 0.00438132826235516 NA NA NA hsa-miR-129-5p RALA -2.56914016541176 2.36237896095709e-06 0.429597265996658 0.0108840636633701 miRanda -0.104300843482996 1.00528498077785e-06 NA NA NA hsa-miR-29c-3p RALA -1.62454036584589 5.38376515586029e-07 0.429597265996658 0.0108840636633701 miRNATAP -0.122352380566726 0.000641186267085384 NA NA NA hsa-miR-30a-3p RALA -1.73205137750899 3.2425754511091e-07 0.429597265996658 0.0108840636633701 MirTarget;miRNATAP -0.146311942178377 1.57770112987793e-05 NA NA NA hsa-miR-30e-3p RALA -0.913131357083321 7.29096855615228e-06 0.429597265996658 0.0108840636633701 MirTarget;miRNATAP -0.23027649626231 7.39143969190828e-05 NA NA NA hsa-miR-328-3p RALA -0.380419131085598 0.160877064911118 0.429597265996658 0.0108840636633701 MirTarget -0.188183079986256 1.84929590415905e-05 NA NA NA hsa-let-7f-5p RALB 0.634633924115866 0.0344982923411787 0.360515976911546 0.0993338462281837 MirTarget;miRNATAP -0.140672617809202 0.0066924217271595 NA NA NA hsa-let-7g-5p RALB 0.325297685027927 0.241142963826631 0.360515976911546 0.0993338462281837 MirTarget;miRNATAP -0.229576146484751 3.84737663161621e-05 NA NA NA hsa-miR-2110 RALB 0.759864042760204 0.0723961390557655 0.360515976911546 0.0993338462281837 MirTarget -0.118973107365176 0.00130164282016964 NA NA NA hsa-miR-30a-3p RALB -1.73205137750899 3.2425754511091e-07 0.360515976911546 0.0993338462281837 MirTarget -0.14678741266286 0.000932973080679265 NA NA NA hsa-miR-30d-3p RALB -0.545113326540761 0.0433733076874155 0.360515976911546 0.0993338462281837 MirTarget -0.156916522704974 0.0067427217785585 NA NA NA hsa-miR-30e-3p RALB -0.913131357083321 7.29096855615228e-06 0.360515976911546 0.0993338462281837 MirTarget -0.302935630279813 5.66717359394468e-05 NA NA NA hsa-miR-491-5p RALB -0.693578126269305 0.0313646742330058 0.360515976911546 0.0993338462281837 miRanda -0.139848800495587 0.00453245296930459 NA NA NA hsa-miR-664a-5p RALB -0.134698715850215 0.624350535385503 0.360515976911546 0.0993338462281837 MirTarget -0.264029879406151 3.38094084896286e-06 NA NA NA hsa-miR-340-5p RALBP1 -0.164941927483643 0.529910509321278 0.107636639186758 0.57765108034511 mirMAP -0.147102151679763 0.00517101199821161 NA NA NA hsa-miR-454-3p RALBP1 0.625199142970745 0.0134890997402741 0.107636639186758 0.57765108034511 MirTarget;miRNATAP -0.142452530403173 0.00873176927403745 NA NA NA hsa-miR-186-5p RALGDS 0.149964130725901 0.434709542998771 0.0866822717927533 0.694872871559898 miRNAWalker2_validate -0.241228155298833 0.00391437771319339 NA NA NA hsa-miR-26a-5p RALGDS -0.384110714440647 0.0442498636014044 0.0866822717927533 0.694872871559898 miRNATAP -0.256183578831225 0.00218034911153437 NA NA NA hsa-miR-335-5p RALGDS 1.59953351087307 5.56170899867314e-05 0.0866822717927533 0.694872871559898 miRNAWalker2_validate -0.13095348915688 0.000669968499444937 NA NA NA hsa-miR-543 RALGDS 0.0323775903217254 0.929458442755522 0.0866822717927533 0.694872871559898 miRanda -0.142639673867797 0.00252056244468234 NA NA NA hsa-miR-7-1-3p RALGDS 0.709309110750947 0.0412301737463194 0.0866822717927533 0.694872871559898 MirTarget -0.128035376855155 0.00439220978978654 NA NA NA hsa-let-7b-3p RAP1A 0.21838629112113 0.296038413622566 -0.772501622846852 5.1689262273662e-06 mirMAP -0.217079459567573 0.000264442278966232 NA NA NA hsa-let-7f-1-3p RAP1A 1.28704406797397 1.17954701106157e-06 -0.772501622846852 5.1689262273662e-06 mirMAP -0.167069513819751 0.000211876689647579 NA NA NA hsa-miR-16-1-3p RAP1A 1.43227522002564 3.70920454953168e-08 -0.772501622846852 5.1689262273662e-06 MirTarget -0.134631650461086 0.0033164342397994 NA NA NA hsa-miR-16-2-3p RAP1A 1.8048179609245 2.83095715136409e-09 -0.772501622846852 5.1689262273662e-06 MirTarget;mirMAP -0.200240334476887 1.2724386289425e-07 NA NA NA hsa-miR-24-3p RAP1A 1.08578167539644 6.18549359075268e-07 -0.772501622846852 5.1689262273662e-06 MirTarget -0.166797591955946 0.00266552085157724 NA NA NA hsa-miR-25-3p RAP1A 1.00604871526544 0.000421838061147906 -0.772501622846852 5.1689262273662e-06 mirMAP -0.129283658956735 0.00242095975751324 NA NA NA hsa-miR-324-5p RAP1A 1.08820215809537 3.11674414561836e-05 -0.772501622846852 5.1689262273662e-06 miRanda -0.126768604988696 0.00638929526461107 NA NA NA hsa-miR-335-3p RAP1A 2.5197689063267 2.20084506976733e-09 -0.772501622846852 5.1689262273662e-06 mirMAP -0.140810699066517 2.26681625031595e-07 NA NA NA hsa-miR-3913-5p RAP1A 0.878857760706319 0.00310224428304055 -0.772501622846852 5.1689262273662e-06 mirMAP -0.190850329131178 2.6242221182578e-06 NA NA NA hsa-miR-550a-3p RAP1A 2.05849884025997 7.99642185793604e-07 -0.772501622846852 5.1689262273662e-06 miRNATAP -0.132977048127842 2.0082553605051e-05 NA NA NA hsa-miR-590-5p RAP1A 1.04171442093217 0.000272475544954865 -0.772501622846852 5.1689262273662e-06 miRanda -0.124133751597277 0.00348053373625042 NA NA NA hsa-miR-92a-3p RAP1A 1.2209325870225 6.8757197708107e-06 -0.772501622846852 5.1689262273662e-06 mirMAP;miRNATAP -0.249902757513225 6.45614852944572e-09 NA NA NA hsa-miR-92b-3p RAP1A 1.33518446513417 1.45350885391576e-06 -0.772501622846852 5.1689262273662e-06 mirMAP;miRNATAP -0.141196217895113 0.00109118916644374 NA NA NA hsa-miR-186-5p RAPGEF5 0.149964130725901 0.434709542998771 0.79531993081387 0.000347499003409621 mirMAP -0.324545964305898 0.000130299150231643 NA NA NA hsa-miR-320b RAPGEF5 1.11183660885284 0.000497971211648503 0.79531993081387 0.000347499003409621 miRanda;mirMAP -0.143102136159291 0.00390863078339008 NA NA NA hsa-miR-340-5p RAPGEF5 -0.164941927483643 0.529910509321278 0.79531993081387 0.000347499003409621 mirMAP -0.199833707493365 0.00113477974076169 NA NA NA hsa-miR-664a-5p RAPGEF5 -0.134698715850215 0.624350535385503 0.79531993081387 0.000347499003409621 mirMAP -0.160923985581624 0.00694474742797598 NA NA NA hsa-miR-361-5p RASA1 0.407725414130987 0.0181260969156347 0.0522348686686147 0.756194566050682 miRanda -0.209203208349243 0.00302450346969509 NA NA NA hsa-miR-141-3p RASA4 1.45548825076434 0.00115958850961764 -0.613631900236935 0.0364881501960043 mirMAP -0.248573759153987 2.85854980657415e-08 NA NA NA hsa-miR-19b-1-5p RASA4 1.38738648038895 1.3113681938066e-06 -0.613631900236935 0.0364881501960043 mirMAP -0.237898842804835 0.000829596303018024 NA NA NA hsa-miR-200a-3p RASA4 0.717826667295984 0.193912116506827 -0.613631900236935 0.0364881501960043 mirMAP -0.149621484948054 6.17664498160212e-05 NA NA NA hsa-miR-331-3p RASA4 1.04880525429426 9.99995355989124e-05 -0.613631900236935 0.0364881501960043 mirMAP -0.299173561963918 8.70854684668719e-05 NA NA NA hsa-miR-424-5p RASA4 1.08509868581983 0.000420473853818268 -0.613631900236935 0.0364881501960043 mirMAP -0.232697587712377 0.000521966443737469 NA NA NA hsa-miR-452-3p RASA4 2.2028815467959 0.00185370432491004 -0.613631900236935 0.0364881501960043 MirTarget -0.101605993191944 0.00197714423904132 NA NA NA hsa-miR-590-3p RASA4 1.11654983899947 0.000160782154924864 -0.613631900236935 0.0364881501960043 miRanda;mirMAP -0.180919719784088 0.0098991957783594 NA NA NA hsa-miR-940 RASA4 1.64406174271686 0.000690854900107004 -0.613631900236935 0.0364881501960043 mirMAP -0.174834343755615 0.000484043041763885 NA NA NA hsa-miR-186-5p RASAL2 0.149964130725901 0.434709542998771 0.350109451597565 0.123270343112062 mirMAP -0.255094725321759 0.00307698844600666 NA NA NA hsa-miR-26b-3p RASAL2 -0.0103961389461977 0.965770899625511 0.350109451597565 0.123270343112062 MirTarget -0.205246676239167 0.00234597211202551 NA NA NA hsa-miR-26b-5p RASAL2 -0.301646326928219 0.160081421968103 0.350109451597565 0.123270343112062 miRNAWalker2_validate -0.225642098777152 0.00314161493929128 NA NA NA hsa-miR-30d-3p RASAL2 -0.545113326540761 0.0433733076874155 0.350109451597565 0.123270343112062 mirMAP -0.166684675287071 0.00556337787662693 NA NA NA hsa-miR-30e-3p RASAL2 -0.913131357083321 7.29096855615228e-06 0.350109451597565 0.123270343112062 mirMAP -0.24658540386368 0.00174872352652163 NA NA NA hsa-miR-340-5p RASAL2 -0.164941927483643 0.529910509321278 0.350109451597565 0.123270343112062 mirMAP -0.199197029415318 0.00129690990147587 NA NA NA hsa-miR-324-5p RASAL3 1.08820215809537 3.11674414561836e-05 0.176190681129671 0.641165786478779 miRanda -0.268781895802891 0.00832383445395627 NA NA NA hsa-let-7a-3p RASGRF2 0.503048155002889 0.0411145454335299 -0.110309077538892 0.784525220880563 mirMAP -0.472702906326776 4.69406106421052e-05 NA NA NA hsa-let-7b-3p RASGRF2 0.21838629112113 0.296038413622566 -0.110309077538892 0.784525220880563 mirMAP -0.404882396564303 0.00382189101035453 NA NA NA hsa-miR-106b-5p RASGRF2 1.70863907461894 2.04074794107142e-08 -0.110309077538892 0.784525220880563 MirTarget -0.270879412386259 0.00289856195344377 NA NA NA hsa-miR-17-5p RASGRF2 1.65862087862483 8.45603406215941e-08 -0.110309077538892 0.784525220880563 MirTarget;TargetScan -0.268490094318991 0.00277983925629893 NA NA NA hsa-miR-182-5p RASGRF2 0.887369486030646 0.0310640781418789 -0.110309077538892 0.784525220880563 mirMAP -0.348530339774225 2.66556386326429e-07 NA NA NA hsa-miR-20a-5p RASGRF2 1.4503375861709 5.7813456424762e-07 -0.110309077538892 0.784525220880563 MirTarget -0.255067154431753 0.00830339669437364 NA NA NA hsa-miR-224-5p RASGRF2 2.7648036144402 0.000111736336240167 -0.110309077538892 0.784525220880563 MirTarget -0.151144416874801 9.92307863285326e-05 NA NA NA hsa-miR-3065-5p RASGRF2 -0.241623656423063 0.633116553078159 -0.110309077538892 0.784525220880563 mirMAP -0.194815043185266 0.000742491857024403 NA NA NA hsa-miR-324-5p RASGRF2 1.08820215809537 3.11674414561836e-05 -0.110309077538892 0.784525220880563 miRNATAP -0.329249943424611 0.00238610953565126 NA NA NA hsa-miR-590-5p RASGRF2 1.04171442093217 0.000272475544954865 -0.110309077538892 0.784525220880563 miRanda -0.344571007524197 0.000490057355380908 NA NA NA hsa-miR-324-3p RASGRP2 1.04940352369965 0.000387716796520961 -1.81023681128664 0.00024193779088964 PITA -0.61614188158445 1.27289198442174e-07 NA NA NA hsa-miR-484 RASGRP2 0.71327898984355 0.00233605130771196 -1.81023681128664 0.00024193779088964 PITA -0.615721134776884 4.65040498472232e-05 NA NA NA hsa-miR-940 RASGRP2 1.64406174271686 0.000690854900107004 -1.81023681128664 0.00024193779088964 MirTarget;PITA;miRNATAP -0.484691818914087 5.3351959566511e-09 NA NA NA hsa-miR-324-3p RASGRP3 1.04940352369965 0.000387716796520961 -0.0864115642863696 0.815827574333325 MirTarget -0.462187758782577 7.85805142563284e-08 NA NA NA hsa-miR-34c-5p RASGRP3 2.20632574870337 0.000379662996168678 -0.0864115642863696 0.815827574333325 miRanda -0.204699381447158 6.39509119948026e-07 NA NA NA hsa-miR-365a-3p RASGRP3 -0.891537000455889 0.0025537650440002 -0.0864115642863696 0.815827574333325 MirTarget -0.471191895625401 4.97718056766004e-08 NA NA NA hsa-miR-944 RASGRP3 3.33123095809751 0.0177835044930391 -0.0864115642863696 0.815827574333325 mirMAP -0.186294617320451 1.33302684859812e-20 NA NA NA hsa-miR-30b-3p RASGRP4 -0.266398938200332 0.400847813143994 -0.503046296554765 0.202621870436041 MirTarget -0.242394213658848 0.00657964905583331 NA NA NA hsa-miR-577 RASGRP4 0.911619788986754 0.2256062124148 -0.503046296554765 0.202621870436041 miRNATAP -0.157500037587732 2.85843806310828e-05 NA NA NA hsa-miR-616-5p RASGRP4 0.834052908652744 0.0347835664029363 -0.503046296554765 0.202621870436041 MirTarget -0.269569241003242 0.000169961330303463 NA NA NA hsa-miR-342-3p RASSF1 0.318119432680668 0.269150960124243 -0.278399268420359 0.187863204184993 PITA;miRNATAP -0.203885758783446 8.61139899748433e-05 NA NA NA hsa-miR-320b RASSF5 1.11183660885284 0.000497971211648503 0.0104707117784946 0.974761055234356 miRanda -0.22063339380264 0.00243105731448585 NA NA NA hsa-miR-326 RASSF5 -0.429748586406214 0.2629894124021 0.0104707117784946 0.974761055234356 miRanda -0.224630350917543 0.000260163329729643 NA NA NA hsa-miR-3662 RASSF5 1.82780708047676 0.0054036501346178 0.0104707117784946 0.974761055234356 mirMAP -0.134157385512903 0.00337626837365891 NA NA NA hsa-miR-532-5p RASSF5 0.313080805824184 0.252248939356301 0.0104707117784946 0.974761055234356 PITA;miRNATAP -0.280275824055563 0.00117784693785741 NA NA NA hsa-miR-101-5p RELA -0.567139223563276 0.0306291767849722 0.140295374000207 0.30305268869391 mirMAP -0.114893897809984 0.00171325410868005 NA NA NA hsa-miR-30e-5p RELA -0.573784818166736 0.0112497802572927 0.140295374000207 0.30305268869391 miRNAWalker2_validate -0.152968732905743 0.000301446483160409 NA NA NA hsa-miR-130b-5p RGL1 0.701350393759937 0.0510142718395002 -0.191763581676769 0.508142560494015 mirMAP -0.20163894405942 0.000386825972582781 NA NA NA hsa-miR-135b-5p RGL1 4.09156383496059 1.32294295002438e-12 -0.191763581676769 0.508142560494015 MirTarget -0.138998151443423 2.53112626074079e-05 NA NA NA hsa-miR-17-5p RGL1 1.65862087862483 8.45603406215941e-08 -0.191763581676769 0.508142560494015 MirTarget;TargetScan;miRNATAP -0.242329901436402 0.000151026498323391 NA NA NA hsa-miR-182-5p RGL1 0.887369486030646 0.0310640781418789 -0.191763581676769 0.508142560494015 MirTarget -0.197626720063671 5.97826068986574e-05 NA NA NA hsa-miR-19a-3p RGL1 1.26669687448473 0.000105972838514412 -0.191763581676769 0.508142560494015 MirTarget;miRNATAP -0.1930583444283 0.00183074664262863 NA NA NA hsa-miR-19b-3p RGL1 0.759818275708988 0.00652779573186786 -0.191763581676769 0.508142560494015 MirTarget;miRNATAP -0.205092565600662 0.00536547521251507 NA NA NA hsa-miR-200b-3p RGL1 0.974577911407732 0.0595020056914543 -0.191763581676769 0.508142560494015 MirTarget;TargetScan -0.180963395559224 3.20946473179119e-06 NA NA NA hsa-miR-200c-3p RGL1 1.28185685499076 0.00369777635539177 -0.191763581676769 0.508142560494015 MirTarget;miRNATAP -0.244702709767558 4.82946081060938e-08 NA NA NA hsa-miR-20a-5p RGL1 1.4503375861709 5.7813456424762e-07 -0.191763581676769 0.508142560494015 MirTarget;miRNATAP -0.219961061652652 0.00144319497888638 NA NA NA hsa-miR-339-5p RGL1 0.770566566962108 0.00816529093411862 -0.191763581676769 0.508142560494015 miRNATAP -0.228322958107481 0.0011690880146713 NA NA NA hsa-miR-429 RGL1 1.40182602301928 0.00900426780286475 -0.191763581676769 0.508142560494015 MirTarget;PITA;miRanda;miRNATAP -0.203321391900717 3.48430033899421e-08 NA NA NA hsa-miR-582-3p RGL1 -0.412897415951272 0.202939245403793 -0.191763581676769 0.508142560494015 PITA -0.199065410524535 0.00172128423994546 NA NA NA hsa-miR-615-3p RGL1 2.82967143704683 3.05118423223543e-05 -0.191763581676769 0.508142560494015 miRanda -0.130442899635746 0.00148395078514525 NA NA NA hsa-miR-92a-3p RGL1 1.2209325870225 6.8757197708107e-06 -0.191763581676769 0.508142560494015 MirTarget -0.262296896965927 0.000405186146801163 NA NA NA hsa-miR-96-5p RGL1 1.14243043653372 0.00942969392739105 -0.191763581676769 0.508142560494015 mirMAP -0.192316525011144 6.51375059941419e-05 NA NA NA hsa-miR-142-3p RGL2 1.32364054836498 0.0001537753622128 -0.523925444567004 0.00192804917067069 miRanda;miRNATAP -0.12610151699536 0.000183646438631939 NA NA NA hsa-miR-374a-3p RHOA 0.0420912023953779 0.851478041312794 -0.153232195967854 0.280834733958971 MirTarget;miRNATAP -0.118847874300155 0.00865724057422007 NA NA NA hsa-miR-1306-3p RRAS 0.330765927739412 0.365190645009445 -0.183682512102821 0.459473778131959 MirTarget -0.163033978538963 0.00195980072819489 NA NA NA hsa-miR-140-3p RRAS2 -0.296251775392129 0.127539826012144 0.0873449649116278 0.798145291977902 MirTarget;PITA;miRNATAP -0.514008282683254 4.71090508973884e-05 NA NA NA hsa-miR-194-5p RRAS2 -0.127742909829168 0.906065815804667 0.0873449649116278 0.798145291977902 MirTarget -0.151162480440524 8.10066422714336e-13 NA NA NA hsa-miR-29a-3p RRAS2 -0.113012156986374 0.615005009685815 0.0873449649116278 0.798145291977902 miRNATAP -0.341167254052947 0.00186147270079613 NA NA NA hsa-miR-29b-3p RRAS2 -0.230693226193598 0.367461626035234 0.0873449649116278 0.798145291977902 miRNATAP -0.300702022169431 0.00166288771949774 NA NA NA hsa-miR-29c-3p RRAS2 -1.62454036584589 5.38376515586029e-07 0.0873449649116278 0.798145291977902 miRNATAP -0.231042616010446 0.00147813263877111 NA NA NA hsa-miR-30a-5p RRAS2 -1.71922855140016 3.20574349285256e-07 0.0873449649116278 0.798145291977902 miRNATAP -0.197676570068884 0.00479286525967713 NA NA NA hsa-miR-30d-5p RRAS2 -0.5492586056147 0.0140125082460125 0.0873449649116278 0.798145291977902 miRNATAP -0.352053143425455 0.0012774863816614 NA NA NA hsa-miR-429 RRAS2 1.40182602301928 0.00900426780286475 0.0873449649116278 0.798145291977902 PITA;miRanda -0.120932450936441 0.00691410403298922 NA NA NA hsa-miR-7-5p RRAS2 1.63575693499363 0.0124424214624534 0.0873449649116278 0.798145291977902 miRNAWalker2_validate;MirTarget;miRNATAP -0.148893985928987 9.31253229982355e-05 NA NA NA hsa-miR-10a-3p SHC1 0.221754213874695 0.560576719784617 0.343733473446102 0.0752374098805381 mirMAP -0.101425944466199 0.00608837897375379 NA NA NA hsa-miR-10a-5p SHC1 -0.470861534765518 0.148803248989189 0.343733473446102 0.0752374098805381 miRNATAP -0.137025993179361 0.0011009888691218 NA NA NA hsa-miR-30b-5p SHC1 -0.430720743745757 0.0593564057320791 0.343733473446102 0.0752374098805381 miRNAWalker2_validate -0.255749685185997 1.99416958422103e-05 NA NA NA hsa-miR-326 SHC1 -0.429748586406214 0.2629894124021 0.343733473446102 0.0752374098805381 miRanda -0.13135964157949 0.000249310812065623 NA NA NA hsa-miR-378a-5p SHC3 -0.557166502179376 0.0344581590006454 -0.468848220659255 0.395271594049155 MirTarget -0.407434515186966 0.00660295984212759 NA NA NA hsa-miR-142-5p SHC4 1.55592486377018 6.69269968016779e-06 -0.252095386644269 0.587399108921422 PITA -0.297381340406308 0.00144110345692059 NA NA NA hsa-miR-150-5p SHC4 0.147461377429675 0.753719621305461 -0.252095386644269 0.587399108921422 MirTarget -0.237966117033369 0.000669599173136894 NA NA NA hsa-miR-151a-3p SHC4 1.00322719901751 7.20903658270795e-06 -0.252095386644269 0.587399108921422 MirTarget -0.492883805890106 0.000734328697523829 NA NA NA hsa-miR-16-1-3p SHC4 1.43227522002564 3.70920454953168e-08 -0.252095386644269 0.587399108921422 MirTarget -0.319276123889654 0.009910011783548 NA NA NA hsa-miR-186-5p SHC4 0.149964130725901 0.434709542998771 -0.252095386644269 0.587399108921422 MirTarget;mirMAP -0.58125599099529 0.00096310841071502 NA NA NA hsa-miR-20a-3p SHC4 1.13957127410163 0.000451087640268489 -0.252095386644269 0.587399108921422 miRNATAP -0.324775907014521 0.0012137038850753 NA NA NA hsa-miR-324-3p SHC4 1.04940352369965 0.000387716796520961 -0.252095386644269 0.587399108921422 PITA -0.292302286895668 0.00843041774574492 NA NA NA hsa-miR-330-3p SHC4 0.798460296022179 0.00746538156533435 -0.252095386644269 0.587399108921422 PITA;miRNATAP -0.372768118472798 0.000706306919992909 NA NA NA hsa-miR-335-3p SHC4 2.5197689063267 2.20084506976733e-09 -0.252095386644269 0.587399108921422 mirMAP -0.215600118964644 0.00406317632265543 NA NA NA hsa-miR-335-5p SHC4 1.59953351087307 5.56170899867314e-05 -0.252095386644269 0.587399108921422 miRNAWalker2_validate -0.249320638061495 0.002240125868243 NA NA NA hsa-miR-429 SHC4 1.40182602301928 0.00900426780286475 -0.252095386644269 0.587399108921422 miRanda -0.280901984856799 2.69399627931691e-06 NA NA NA hsa-miR-576-5p SHC4 0.625714137488957 0.0417100301848969 -0.252095386644269 0.587399108921422 mirMAP -0.317711735491466 0.00315434680436629 NA NA NA hsa-miR-577 SHC4 0.911619788986754 0.2256062124148 -0.252095386644269 0.587399108921422 mirMAP -0.131528645483696 0.00328813359926571 NA NA NA hsa-miR-590-3p SHC4 1.11654983899947 0.000160782154924864 -0.252095386644269 0.587399108921422 PITA;miRanda;mirMAP;miRNATAP -0.305235220819571 0.00577466718096053 NA NA NA hsa-miR-590-5p SHC4 1.04171442093217 0.000272475544954865 -0.252095386644269 0.587399108921422 miRanda -0.346829912079823 0.00241962419809176 NA NA NA hsa-miR-103a-3p SHOC2 0.840525139266028 5.83536475789158e-07 -0.207809996837827 0.0947494203647125 miRNAWalker2_validate -0.205922962613427 6.2880672040407e-05 NA NA NA hsa-miR-106b-5p SHOC2 1.70863907461894 2.04074794107142e-08 -0.207809996837827 0.0947494203647125 MirTarget;miRNATAP -0.119243110073989 1.23736697499781e-05 NA NA NA hsa-miR-128-3p SHOC2 0.98280381420517 5.77641850797209e-05 -0.207809996837827 0.0947494203647125 MirTarget -0.126043598600206 0.000342743981229067 NA NA NA hsa-miR-15b-5p SHOC2 1.62046407540723 5.42152621571078e-09 -0.207809996837827 0.0947494203647125 MirTarget;miRNATAP -0.125552195787411 2.77192877353949e-05 NA NA NA hsa-miR-16-5p SHOC2 1.00515772948091 5.33912942007619e-06 -0.207809996837827 0.0947494203647125 miRNAWalker2_validate;MirTarget;miRNATAP -0.117662082883652 0.00260371119379409 NA NA NA hsa-miR-361-5p SHOC2 0.407725414130987 0.0181260969156347 -0.207809996837827 0.0947494203647125 PITA;miRanda -0.147889688061407 0.00439289203428905 NA NA NA hsa-miR-92a-3p SHOC2 1.2209325870225 6.8757197708107e-06 -0.207809996837827 0.0947494203647125 miRNAWalker2_validate -0.130738570920158 2.81342670354768e-05 NA NA NA hsa-miR-107 SOS1 0.904627575346218 4.67936495073904e-05 -0.312504597403338 0.0217354056927372 miRNATAP -0.145548441179847 0.000689923594720433 NA NA NA hsa-miR-212-3p SOS1 0.960352937108106 0.00133449812322732 -0.312504597403338 0.0217354056927372 miRNATAP -0.10285303580697 0.00125914157136999 NA NA NA hsa-miR-130b-3p SOS2 1.32714007211004 4.78676252285191e-05 -0.552553272187832 0.000842904756234712 miRNATAP -0.189945286925012 4.30620481406807e-08 NA NA NA hsa-miR-140-5p SOS2 0.208193069681326 0.303002433893804 -0.552553272187832 0.000842904756234712 miRanda -0.242708772607705 4.09198894582034e-05 NA NA NA hsa-miR-15a-5p SOS2 1.03783090449383 7.40334108980898e-07 -0.552553272187832 0.000842904756234712 miRNATAP -0.146415389758913 0.00881073243847914 NA NA NA hsa-miR-15b-5p SOS2 1.62046407540723 5.42152621571078e-09 -0.552553272187832 0.000842904756234712 miRNATAP -0.20706350866124 2.57218450390641e-07 NA NA NA hsa-miR-16-5p SOS2 1.00515772948091 5.33912942007619e-06 -0.552553272187832 0.000842904756234712 miRNATAP -0.262605428938621 4.24308774338413e-07 NA NA NA hsa-miR-320a SOS2 0.593888711838028 0.011897419390526 -0.552553272187832 0.000842904756234712 miRanda;miRNATAP -0.171180096354768 0.000654323522825758 NA NA NA hsa-miR-320b SOS2 1.11183660885284 0.000497971211648503 -0.552553272187832 0.000842904756234712 miRanda;miRNATAP -0.1894426744384 1.1640268989058e-07 NA NA NA hsa-miR-320c SOS2 0.455072851945474 0.240613785444485 -0.552553272187832 0.000842904756234712 miRanda;miRNATAP -0.140084445378509 6.27193555893877e-05 NA NA NA hsa-miR-330-3p SOS2 0.798460296022179 0.00746538156533435 -0.552553272187832 0.000842904756234712 PITA;miRNATAP -0.138104773165596 0.000447681879316435 NA NA NA hsa-miR-335-5p SOS2 1.59953351087307 5.56170899867314e-05 -0.552553272187832 0.000842904756234712 miRNAWalker2_validate -0.169702199646938 1.79676990124387e-09 NA NA NA hsa-miR-421 SOS2 1.80720854070385 1.59709651202848e-07 -0.552553272187832 0.000842904756234712 miRanda -0.144587437231913 1.02531118763523e-05 NA NA NA hsa-miR-424-5p SOS2 1.08509868581983 0.000420473853818268 -0.552553272187832 0.000842904756234712 miRNATAP -0.140604926460313 0.000199731330671148 NA NA NA hsa-miR-543 SOS2 0.0323775903217254 0.929458442755522 -0.552553272187832 0.000842904756234712 miRanda -0.111995751787288 0.00169071143522402 NA NA NA hsa-miR-590-3p SOS2 1.11654983899947 0.000160782154924864 -0.552553272187832 0.000842904756234712 miRanda;mirMAP -0.153192018213884 9.25459377799179e-05 NA NA NA hsa-miR-590-5p SOS2 1.04171442093217 0.000272475544954865 -0.552553272187832 0.000842904756234712 PITA;miRanda;miRNATAP -0.180915954835414 7.34917806636463e-06 NA NA NA hsa-miR-224-3p STK4 1.52422171450716 0.00650463542340912 0.548178366011 0.00108978985662648 MirTarget -0.105835326254386 3.48605814034794e-06 NA NA NA hsa-miR-23a-3p STK4 1.10685926969665 3.16223452471768e-08 0.548178366011 0.00108978985662648 MirTarget;miRNATAP -0.226204595257245 0.000108440594494015 NA NA NA hsa-miR-23b-3p STK4 -0.286465516491361 0.18664668472995 0.548178366011 0.00108978985662648 MirTarget;miRNATAP -0.344576266131766 1.68450726412007e-10 NA NA NA hsa-let-7g-3p SYNGAP1 0.64979533805273 0.0103084600883006 -0.0430542043594411 0.821891645111544 miRNATAP -0.155130253636972 0.00375257086338187 NA NA NA hsa-miR-29a-3p SYNGAP1 -0.113012156986374 0.615005009685815 -0.0430542043594411 0.821891645111544 miRNATAP -0.233216643938155 0.000120565277402883 NA NA NA hsa-miR-29b-3p SYNGAP1 -0.230693226193598 0.367461626035234 -0.0430542043594411 0.821891645111544 miRNATAP -0.178191735074037 0.000801000708399113 NA NA NA hsa-miR-330-5p SYNGAP1 0.488365986827708 0.0512207630808233 -0.0430542043594411 0.821891645111544 PITA;mirMAP;miRNATAP -0.152100059593684 0.00516356706199373 NA NA NA hsa-miR-331-3p SYNGAP1 1.04880525429426 9.99995355989124e-05 -0.0430542043594411 0.821891645111544 PITA;mirMAP;miRNATAP -0.156226008442455 0.00161059778452958 NA NA NA hsa-miR-339-5p SYNGAP1 0.770566566962108 0.00816529093411862 -0.0430542043594411 0.821891645111544 PITA;miRNATAP -0.155267041396571 0.000763448031140454 NA NA NA hsa-miR-361-3p SYNGAP1 -0.126462931388735 0.566052688733137 -0.0430542043594411 0.821891645111544 PITA;miRNATAP -0.18583704969062 0.00288805398276418 NA NA NA hsa-miR-362-3p SYNGAP1 -0.0349414695893027 0.913780708043777 -0.0430542043594411 0.821891645111544 PITA;miRanda;miRNATAP -0.175839253693247 2.45531683706017e-05 NA NA NA hsa-miR-429 SYNGAP1 1.40182602301928 0.00900426780286475 -0.0430542043594411 0.821891645111544 miRNATAP -0.139578079331329 7.07817441114777e-09 NA NA NA hsa-miR-625-5p SYNGAP1 0.537211086526376 0.203801009380384 -0.0430542043594411 0.821891645111544 mirMAP -0.173252275544776 2.70475561957082e-08 NA NA NA hsa-miR-629-3p SYNGAP1 1.40326397107309 9.7803063526732e-05 -0.0430542043594411 0.821891645111544 mirMAP;miRNATAP -0.12036886441665 0.00106384586956799 NA NA NA hsa-miR-455-5p TEK 1.20462751989145 6.74386011867484e-05 -1.42722193756898 0.000475412039481098 miRanda -0.484594750557798 2.54479265582421e-07 NA NA NA hsa-miR-129-5p TGFA -2.56914016541176 2.36237896095709e-06 1.61763558221504 5.79988353685113e-05 miRanda;mirMAP -0.207133950005876 7.95124452667339e-05 NA NA NA hsa-miR-140-3p TGFA -0.296251775392129 0.127539826012144 1.61763558221504 5.79988353685113e-05 miRNATAP -0.686146361756192 5.69340498351293e-06 NA NA NA hsa-miR-29b-2-5p TGFA -1.7015307882027 2.84239251703401e-10 1.61763558221504 5.79988353685113e-05 mirMAP -0.601645583066598 1.97477345184881e-09 NA NA NA hsa-miR-326 TGFA -0.429748586406214 0.2629894124021 1.61763558221504 5.79988353685113e-05 miRanda -0.227020831163258 0.00313889373116187 NA NA NA hsa-miR-338-5p TGFA -1.19659203838734 0.0100316010080496 1.61763558221504 5.79988353685113e-05 mirMAP -0.184244887734986 0.00305770189496924 NA NA NA hsa-miR-10a-5p TIAM1 -0.470861534765518 0.148803248989189 -0.0122685425659981 0.984856081850572 MirTarget;miRNATAP -0.687817220114406 6.71552826187485e-07 26870215 Expression of microRNA 10a microRNA 342 3p and their predicted target gene TIAM1 in extranodal NK/T cell lymphoma nasal type; In the present study the association between the expression levels of miR-10a and miR-342-3p and the protein expression levels of TIAM1 was examined in ENKTCL tissues lymphoma hsa-miR-1266-5p TIAM1 0.214881660714884 0.741561405223711 -0.0122685425659981 0.984856081850572 MirTarget -0.426447724753113 5.10101398869343e-10 NA NA NA hsa-miR-188-5p TIAM1 1.35426907033843 0.00038346077691455 -0.0122685425659981 0.984856081850572 MirTarget -0.356631507059937 0.00268185981642072 NA NA NA hsa-miR-200a-3p TIAM1 0.717826667295984 0.193912116506827 -0.0122685425659981 0.984856081850572 MirTarget;miRNATAP -0.320005675997551 9.77578136357517e-05 NA NA NA hsa-miR-29a-5p TIAM1 0.585084040404152 0.023014129158495 -0.0122685425659981 0.984856081850572 MirTarget -0.662087606286906 0.000205260221693055 NA NA NA hsa-miR-29b-3p TIAM1 -0.230693226193598 0.367461626035234 -0.0122685425659981 0.984856081850572 miRNATAP -0.591258172654588 0.00109621357803586 25032858 miR 29b suppresses tumor growth and metastasis in colorectal cancer via downregulating Tiam1 expression and inhibiting epithelial mesenchymal transition; Further studies found that T lymphoma invasion and metastasis 1 Tiam1 was identified as a direct target of miR-29b metastasis colorectal cancer hsa-miR-320b TIAM1 1.11183660885284 0.000497971211648503 -0.0122685425659981 0.984856081850572 miRanda;miRNATAP -0.43400517392437 0.00230432561279731 NA NA NA hsa-miR-335-3p TIAM1 2.5197689063267 2.20084506976733e-09 -0.0122685425659981 0.984856081850572 MirTarget -0.380118694749198 0.000247845574996267 NA NA NA hsa-miR-335-5p TIAM1 1.59953351087307 5.56170899867314e-05 -0.0122685425659981 0.984856081850572 miRNAWalker2_validate -0.395796314744979 0.00046579031765087 NA NA NA hsa-miR-338-3p TIAM1 -0.959276231066179 0.0191473351014091 -0.0122685425659981 0.984856081850572 miRanda -0.709733575833794 2.82910589296384e-11 NA NA NA hsa-miR-362-3p TIAM1 -0.0349414695893027 0.913780708043777 -0.0122685425659981 0.984856081850572 miRanda -0.384214804545815 0.00757244414868255 NA NA NA hsa-miR-592 TIAM1 0.779567202789068 0.204498177014474 -0.0122685425659981 0.984856081850572 PITA -0.447595478238259 7.97370740311574e-09 NA NA NA hsa-miR-1-3p VEGFA -2.66410453456934 1.50620580537836e-05 0.409900110754973 0.180026099055787 MirTarget -0.176948917904965 1.45151759893735e-07 24966896 The ectopic expression of miR-1 and miR-145 in NOZ cells significantly inhibited cell viability and colony formation P<0.01 and reduced gene expression of VEGF-A and AXL bladder cancer hsa-miR-101-3p VEGFA -0.451263906815861 0.0283387250173031 0.409900110754973 0.180026099055787 miRNAWalker2_validate -0.335417986089274 0.00174980396829274 NA NA NA hsa-miR-129-5p VEGFA -2.56914016541176 2.36237896095709e-06 0.409900110754973 0.180026099055787 miRanda -0.105947559794297 0.00736909643879352 NA NA NA hsa-miR-133a-3p VEGFA -3.07408796787523 8.17423849601445e-07 0.409900110754973 0.180026099055787 miRNAWalker2_validate -0.162820736618245 8.37210469369392e-07 NA NA NA hsa-miR-145-5p VEGFA -1.75133578902314 1.54965572197748e-05 0.409900110754973 0.180026099055787 miRNAWalker2_validate;miRTarBase -0.220438811665314 2.09241456816908e-05 24781864;24966896;22472569 Overexpression of miR-145 in thyroid cancer cell lines resulted in: decreased cell proliferation migration invasion VEGF secretion and E-cadherin expression; In vivo miR-145 overexpression decreased tumor growth and metastasis in a xenograft mouse model and VEGF secretion;The ectopic expression of miR-1 and miR-145 in NOZ cells significantly inhibited cell viability and colony formation P<0.01 and reduced gene expression of VEGF-A and AXL;Furthermore the results showed that vascular endothelial growth factor VEGF expression was down-regulated in osteosarcoma cells after miR-145 transfection; On the basis of these results we performed the luciferase assay and verified that miR-145 could down-regulate VEGF at the translational level by partially binding to VEGF 3' untranslated region 3'UTR; One of the mechanisms is the down-regulation of VEGF expression by miR-145 by binding to the 3'UTR of VEGF mRNA specifically metastasis;; thyroid cancer;bladder cancer;sarcoma hsa-miR-199a-5p VEGFA 0.371973504507027 0.232661597228763 0.409900110754973 0.180026099055787 miRanda;miRNATAP -0.211547585175076 0.00251514147236996 25444917 In addition co-transfection with miR-199a mimic reversed the CCL5-mediated VEGF expression and angiogenesis in vitro and in vivo sarcoma hsa-miR-128-3p VEGFC 0.98280381420517 5.77641850797209e-05 0.195788328347819 0.656066637612163 miRNAWalker2_validate;MirTarget -0.546088637678822 1.30628253642657e-05 25001183;26722309 Interestingly ectopic miR-128 overexpression could significantly inhibit vascular endothelial growth factor VEGF-C expression and reduce the activity of a luciferase reporter containing the VEGF-C 3'-untranslated region; These findings suggest that miR-128 could play a role in NSCLC tumourigenesis at least in part by modulation of angiogenesis and lymphangiogenesis through targeting VEGF-C and could simultaneously block ERK AKT and p38 signalling pathways;miR 128 downregulation promotes growth and metastasis of bladder cancer cells and involves VEGF C upregulation; To investigate the regulation of miR-128 on VEGF-C expression and their effects on proliferation and metastasis of bladder cancer T24 and 5637 BC cells were transfected with pre-miR-128 anti-miR-128 and their respective negative control; miR-128 was downregulated in BC tissues and cell lines while the expression levels of VEGF-C were upregulated; The present results indicated that miR-128 negatively regulated VEGF-C expression in BC T24 and 5637 BC cells; VEGF-C is a direct target of miR-128 in BC cells ;metastasis lung squamous cell cancer;bladder cancer hsa-miR-16-2-3p VEGFC 1.8048179609245 2.83095715136409e-09 0.195788328347819 0.656066637612163 MirTarget -0.260465880829614 0.00866041293845893 NA NA NA hsa-miR-3662 VEGFC 1.82780708047676 0.0054036501346178 0.195788328347819 0.656066637612163 MirTarget -0.187356869827338 0.00206421517630613 NA NA NA