miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-29b-3p ABL1 -0.228125979913806 0.0271621721891603 0.0367677644326827 0.557586764156183 miRNATAP -0.119422950033378 0.000331947917061817 NA NA NA hsa-miR-30a-5p ABL1 -0.778411951775343 2.73322451127932e-16 0.0367677644326827 0.557586764156183 miRNAWalker2_validate;MirTarget;miRNATAP -0.119780200950244 0.000523947512657604 23287430 In K562 leukemia cells overexpression of miR-30a reduced ABL1 and BCR-ABL1 protein expression decreased proliferation and arrested cell cycle progression between G1 and S; These findings strongly suggest that miR-30a acts as a tumor suppressor by downregulating ABL1 and BCR-ABL1 expression progression chronic myeloid leukemia hsa-miR-30e-5p ABL1 -0.0905907245198101 0.21196704484334 0.0367677644326827 0.557586764156183 MirTarget;miRNATAP -0.1387897119702 0.00390571974742246 NA NA NA hsa-let-7g-5p ABL2 -0.739744008507763 1.07979566264383e-14 0.743068122228824 1.32491966212443e-22 miRNATAP -0.133983416199351 0.0029771773007798 NA NA NA hsa-miR-10b-3p ABL2 -0.8205021989966 7.84331443044781e-21 0.743068122228824 1.32491966212443e-22 mirMAP -0.179730767107848 0.000189054359284447 NA NA NA hsa-miR-125b-5p ABL2 -0.825456421494266 2.13029877878434e-15 0.743068122228824 1.32491966212443e-22 MirTarget -0.180397103583226 1.08170009123867e-05 NA NA NA hsa-miR-141-3p ABL2 -5.87110686537457 1.20877726722907e-85 0.743068122228824 1.32491966212443e-22 MirTarget;TargetScan;miRNATAP -0.107815762914371 1.08799448425464e-23 NA NA NA hsa-miR-188-5p ABL2 -1.74586655806628 1.50431624674552e-28 0.743068122228824 1.32491966212443e-22 mirMAP -0.200089333716075 9.1801573961769e-15 NA NA NA hsa-miR-200a-3p ABL2 -1.43409013664263 2.00188483717828e-20 0.743068122228824 1.32491966212443e-22 MirTarget;miRNATAP -0.215631044046345 1.02785679745371e-16 NA NA NA hsa-miR-200a-5p ABL2 -1.36295040293874 1.31587720312419e-22 0.743068122228824 1.32491966212443e-22 mirMAP -0.221090158771305 2.05183210796258e-14 NA NA NA hsa-miR-200b-3p ABL2 -1.70383252137161 2.38979336321755e-30 0.743068122228824 1.32491966212443e-22 MirTarget -0.244236946893437 2.46433576209145e-21 NA NA NA hsa-miR-200b-5p ABL2 -1.46985752435972 3.43232443788022e-27 0.743068122228824 1.32491966212443e-22 mirMAP -0.243246105353357 6.40228331470388e-17 NA NA NA hsa-miR-200c-3p ABL2 -5.40303134829523 2.74173143360645e-94 0.743068122228824 1.32491966212443e-22 MirTarget -0.121181735253038 2.42667990899255e-24 NA NA NA hsa-miR-204-5p ABL2 -1.67490789640238 9.14741888352476e-10 0.743068122228824 1.32491966212443e-22 mirMAP -0.101304560197589 6.37182625287106e-11 NA NA NA hsa-miR-20b-5p ABL2 -1.30218163823367 6.87172815978149e-17 0.743068122228824 1.32491966212443e-22 MirTarget -0.10778924000435 7.46375286329919e-05 NA NA NA hsa-miR-27b-3p ABL2 -0.699527231242518 1.07356023759234e-15 0.743068122228824 1.32491966212443e-22 MirTarget;miRNATAP -0.350774987188609 2.0405480841429e-13 NA NA NA hsa-miR-29a-3p ABL2 -0.431613225927952 4.10166815070288e-08 0.743068122228824 1.32491966212443e-22 mirMAP -0.225292235826518 5.91656348439463e-05 NA NA NA hsa-miR-29a-5p ABL2 -0.519003718107105 1.03351148282116e-06 0.743068122228824 1.32491966212443e-22 mirMAP -0.11794885938562 0.00468010228084753 NA NA NA hsa-miR-29b-3p ABL2 -0.228125979913806 0.0271621721891603 0.743068122228824 1.32491966212443e-22 mirMAP -0.113987707815353 0.00893628302949653 NA NA NA hsa-miR-29c-3p ABL2 -0.238671318446745 0.0141475322347596 0.743068122228824 1.32491966212443e-22 mirMAP -0.193997060742996 2.37784597647399e-05 NA NA NA hsa-miR-3065-3p ABL2 -1.64500070417457 9.57561660036697e-16 0.743068122228824 1.32491966212443e-22 mirMAP -0.145748383505374 4.92157663343334e-13 NA NA NA hsa-miR-30a-3p ABL2 -0.955360819934585 1.97009535429185e-20 0.743068122228824 1.32491966212443e-22 mirMAP -0.339338087195527 3.14217174248721e-18 NA NA NA hsa-miR-30a-5p ABL2 -0.778411951775343 2.73322451127932e-16 0.743068122228824 1.32491966212443e-22 mirMAP;miRNATAP -0.391382355482778 4.51845756075468e-20 NA NA NA hsa-miR-30b-5p ABL2 -1.18330589477119 6.8341618466966e-27 0.743068122228824 1.32491966212443e-22 mirMAP -0.324881078971245 4.85114002974158e-20 NA NA NA hsa-miR-30c-5p ABL2 -1.08783070774238 2.02505402525786e-24 0.743068122228824 1.32491966212443e-22 mirMAP;miRNATAP -0.302748327093772 6.27810376295699e-16 NA NA NA hsa-miR-30d-3p ABL2 -0.249777194282131 0.00235356711813496 0.743068122228824 1.32491966212443e-22 mirMAP -0.308929578688416 9.64596466683218e-09 NA NA NA hsa-miR-30d-5p ABL2 -0.202727675788184 0.00659067084745794 0.743068122228824 1.32491966212443e-22 mirMAP;miRNATAP -0.365038513480807 7.54357472996484e-10 NA NA NA hsa-miR-30e-3p ABL2 -0.205602546270795 0.00132666419729688 0.743068122228824 1.32491966212443e-22 mirMAP -0.378850046480116 5.81738956535534e-08 NA NA NA hsa-miR-30e-5p ABL2 -0.0905907245198101 0.21196704484334 0.743068122228824 1.32491966212443e-22 mirMAP -0.296872756633158 1.70099210492037e-06 NA NA NA hsa-miR-33a-5p ABL2 -1.59840463890997 1.13487952314403e-18 0.743068122228824 1.32491966212443e-22 mirMAP -0.117393393240159 4.03236909688847e-07 NA NA NA hsa-miR-429 ABL2 -2.16569233119434 2.66862243626443e-37 0.743068122228824 1.32491966212443e-22 MirTarget -0.220109108328187 8.44729710328758e-24 NA NA NA hsa-miR-500a-5p ABL2 -1.28374735824553 1.95870374809798e-20 0.743068122228824 1.32491966212443e-22 mirMAP -0.239949493915249 1.73702700822783e-16 NA NA NA hsa-let-7b-3p AKT2 0.239865279324672 0.00721479815526816 -0.340477996057433 3.62402949162022e-08 MirTarget -0.103250394013056 0.00819845290941259 NA NA NA hsa-miR-140-5p AKT2 0.504309496243674 3.09884038729031e-11 -0.340477996057433 3.62402949162022e-08 mirMAP -0.257894167615696 4.25294111137846e-09 NA NA NA hsa-miR-193a-3p AKT2 0.849206638484406 3.68101781083335e-14 -0.340477996057433 3.62402949162022e-08 miRanda -0.1602336102543 4.66296866332011e-08 NA NA NA hsa-miR-1976 AKT2 0.343475600930938 0.000360243844871748 -0.340477996057433 3.62402949162022e-08 miRNATAP -0.114100456416688 0.00148676672535644 NA NA NA hsa-miR-21-5p AKT2 2.51462371613332 3.30620591950316e-66 -0.340477996057433 3.62402949162022e-08 miRNAWalker2_validate -0.116002520060245 7.24256492760299e-10 NA NA NA hsa-miR-2355-5p AKT2 1.57515081110162 3.54962327490702e-48 -0.340477996057433 3.62402949162022e-08 mirMAP -0.158007486287123 5.63512797747714e-09 NA NA NA hsa-miR-24-3p AKT2 0.173813044685099 0.00565259443420961 -0.340477996057433 3.62402949162022e-08 mirMAP -0.145738275793208 0.0095430051404417 NA NA NA hsa-miR-330-5p AKT2 1.44960468659754 2.12131210588035e-45 -0.340477996057433 3.62402949162022e-08 miRanda -0.199850402161812 2.39463482226386e-12 NA NA NA hsa-miR-338-3p AKT2 0.906250377628867 2.76970900371139e-15 -0.340477996057433 3.62402949162022e-08 mirMAP -0.160942202850334 1.55482491354725e-08 NA NA NA hsa-miR-342-3p AKT2 1.4124432570595 1.07208971556131e-28 -0.340477996057433 3.62402949162022e-08 mirMAP -0.193694719446483 5.5338386148732e-16 NA NA NA hsa-miR-423-3p AKT2 0.460506077888547 3.44680149368459e-09 -0.340477996057433 3.62402949162022e-08 miRNAWalker2_validate -0.134093002116074 0.00224236224837297 NA NA NA hsa-miR-106b-5p AKT3 1.07509411417907 2.11739194181878e-36 -0.243988630870274 0.0117503955413685 miRNATAP -0.362551297020254 3.77551886386752e-11 NA NA NA hsa-miR-107 AKT3 0.140046250553248 0.0943611632552367 -0.243988630870274 0.0117503955413685 PITA;miRanda -0.284787420850406 8.53745778311515e-06 NA NA NA hsa-miR-146b-5p AKT3 1.40714170253819 2.9559871816487e-12 -0.243988630870274 0.0117503955413685 miRNAWalker2_validate -0.106480044558668 2.77668665683102e-05 NA NA NA hsa-miR-15a-5p AKT3 1.42663930007845 1.36006952074963e-57 -0.243988630870274 0.0117503955413685 miRNAWalker2_validate;miRTarBase;miRNATAP -0.209553352701426 2.74861510149098e-05 NA NA NA hsa-miR-15b-5p AKT3 0.773001494057531 1.71784656078957e-16 -0.243988630870274 0.0117503955413685 miRNATAP -0.179137071242714 0.00102312999530003 NA NA NA hsa-miR-16-5p AKT3 0.934012514027655 4.85417898318515e-24 -0.243988630870274 0.0117503955413685 miRNAWalker2_validate;miRTarBase;miRNATAP -0.174740148583929 0.00122158424330689 NA NA NA hsa-miR-17-3p AKT3 0.723795600017259 5.90151677164931e-18 -0.243988630870274 0.0117503955413685 miRNATAP -0.202376849787589 0.00088737719875351 NA NA NA hsa-miR-17-5p AKT3 0.494260110870015 3.8348005261e-09 -0.243988630870274 0.0117503955413685 TargetScan;miRNATAP -0.190824149294487 0.00237163147001594 NA NA NA hsa-miR-22-3p AKT3 0.198460552200729 0.00761005672059428 -0.243988630870274 0.0117503955413685 miRNATAP -0.407589872687642 1.12041867452881e-08 NA NA NA hsa-miR-29a-3p AKT3 -0.431613225927952 4.10166815070288e-08 -0.243988630870274 0.0117503955413685 miRNATAP -0.244491422189309 0.000269689815704259 NA NA NA hsa-miR-29b-3p AKT3 -0.228125979913806 0.0271621721891603 -0.243988630870274 0.0117503955413685 miRNATAP -0.247981734385757 1.40066355236384e-06 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-374b-5p AKT3 0.0804104684417872 0.365593963035077 -0.243988630870274 0.0117503955413685 mirMAP -0.250536892298211 3.33662467499594e-05 NA NA NA hsa-miR-421 AKT3 0.313155739887734 0.020433534776003 -0.243988630870274 0.0117503955413685 miRanda;mirMAP -0.144627984206661 0.000385343212972084 NA NA NA hsa-miR-542-3p AKT3 0.431147917094433 0.000254981247606435 -0.243988630870274 0.0117503955413685 miRanda -0.173551255334696 0.000111564350795738 NA NA NA hsa-miR-616-5p AKT3 0.913426384742148 3.78418389333709e-09 -0.243988630870274 0.0117503955413685 mirMAP -0.172749202880246 3.16635692442533e-07 NA NA NA hsa-miR-93-5p AKT3 1.37365940377595 2.37567548683245e-46 -0.243988630870274 0.0117503955413685 miRNATAP -0.172188027294336 0.000349761294454902 NA NA NA hsa-miR-146b-5p ANGPT1 1.40714170253819 2.9559871816487e-12 -0.985552064534845 1.94537731705344e-10 miRanda -0.220243977048136 1.0451286572533e-07 NA NA NA hsa-miR-590-3p ANGPT1 1.13702599385212 3.53435739887793e-22 -0.985552064534845 1.94537731705344e-10 PITA;miRanda;mirMAP -0.427703951979757 4.61649825016446e-10 NA NA NA hsa-miR-125a-5p ANGPT2 -0.561874059994802 7.3931856356891e-13 3.2279729131303 1.51342644964021e-50 miRanda -0.591277292988033 0.000656123320213166 NA NA NA hsa-miR-135a-5p ANGPT2 -2.13422485001223 6.29449029671498e-14 3.2279729131303 1.51342644964021e-50 MirTarget -0.282490332765068 2.39173511082776e-09 NA NA NA hsa-miR-335-3p ANGPT2 -1.36498175550207 6.84287752180534e-13 3.2279729131303 1.51342644964021e-50 mirMAP -0.535010814152484 4.07158596361409e-15 NA NA NA hsa-miR-381-3p ANGPT2 -0.674906433524392 0.000234722307243307 3.2279729131303 1.51342644964021e-50 mirMAP -0.333901097103082 9.96762738841714e-06 NA NA NA hsa-miR-429 ANGPT2 -2.16569233119434 2.66862243626443e-37 3.2279729131303 1.51342644964021e-50 miRanda -0.720876199916154 1.69585500076757e-26 NA NA NA hsa-miR-539-5p ANGPT2 -1.44841597031461 8.25650852878567e-11 3.2279729131303 1.51342644964021e-50 mirMAP -0.354280479023757 7.58513939866313e-09 NA NA NA hsa-miR-577 ANGPT2 -1.48881999472397 7.03080165111147e-10 3.2279729131303 1.51342644964021e-50 mirMAP -0.20703264362078 0.000237923717522693 NA NA NA hsa-miR-744-3p ANGPT2 -0.268747126270442 0.0255846712882831 3.2279729131303 1.51342644964021e-50 MirTarget -0.303019314922211 0.00923616581326206 NA NA NA hsa-miR-9-5p ANGPT2 -2.23538606210968 1.28143998950751e-12 3.2279729131303 1.51342644964021e-50 MirTarget -0.155756599777652 0.000249620141111064 NA NA NA hsa-miR-107 ARF6 0.140046250553248 0.0943611632552367 -0.309204545259465 1.40756888061489e-07 MirTarget;miRanda -0.106239764036689 0.00740416473218249 NA NA NA hsa-miR-181a-5p ARF6 1.11111114875339 3.97880443756442e-29 -0.309204545259465 1.40756888061489e-07 miRNAWalker2_validate;MirTarget -0.120171274990503 6.96430040888135e-05 NA NA NA hsa-miR-181b-5p ARF6 1.49054296272357 3.69051660739368e-41 -0.309204545259465 1.40756888061489e-07 MirTarget -0.112985334504157 1.25548759481573e-05 NA NA NA hsa-miR-23a-3p ARF6 0.761438723382355 4.09310879199257e-27 -0.309204545259465 1.40756888061489e-07 MirTarget -0.139865060662754 0.00122632546849196 NA NA NA hsa-miR-505-5p BCL2L1 -0.109332726329313 0.346400159841743 0.056672670469081 0.380838191246795 miRNATAP -0.108957481398792 0.000366888756795515 NA NA NA hsa-miR-182-5p BDNF -0.608710746044567 0.0025264935278104 1.32053589639348 4.6461489093674e-09 MirTarget;miRNATAP -0.320911985212199 2.19358929074297e-07 NA NA NA hsa-miR-22-3p BDNF 0.198460552200729 0.00761005672059428 1.32053589639348 4.6461489093674e-09 miRNAWalker2_validate;miRTarBase -0.934418001650865 4.10404904290013e-08 NA NA NA hsa-miR-3065-3p BDNF -1.64500070417457 9.57561660036697e-16 1.32053589639348 4.6461489093674e-09 MirTarget;miRNATAP -0.173566329974244 0.00341422805602149 NA NA NA hsa-miR-30b-5p BDNF -1.18330589477119 6.8341618466966e-27 1.32053589639348 4.6461489093674e-09 miRNATAP -0.418679389730946 7.95864809848167e-05 NA NA NA hsa-miR-361-5p BDNF 0.0514169367202078 0.382929376393199 1.32053589639348 4.6461489093674e-09 PITA;miRanda;miRNATAP -0.579854997171823 0.00910447765702249 NA NA NA hsa-miR-3913-5p BDNF 0.136365354811444 0.24239516424369 1.32053589639348 4.6461489093674e-09 mirMAP -0.437476166734317 0.000137119405950826 NA NA NA hsa-miR-508-3p BDNF -3.41433288024917 3.47699261121175e-37 1.32053589639348 4.6461489093674e-09 PITA;miRNATAP -0.227379255506386 4.7723104940365e-08 NA NA NA hsa-let-7i-5p CALM1 0.911372377723717 7.11483853341932e-31 -0.376000013914611 2.23560119889328e-10 miRNATAP -0.201789587614692 1.39474010609039e-07 NA NA NA hsa-miR-142-5p CALM1 1.88417391525707 1.2096808039882e-27 -0.376000013914611 2.23560119889328e-10 miRNATAP -0.109277968042153 2.81791123482425e-10 NA NA NA hsa-miR-15a-5p CALM1 1.42663930007845 1.36006952074963e-57 -0.376000013914611 2.23560119889328e-10 miRNATAP -0.153129062774917 8.52928947682562e-07 NA NA NA hsa-miR-15b-5p CALM1 0.773001494057531 1.71784656078957e-16 -0.376000013914611 2.23560119889328e-10 miRNATAP -0.158562223562419 2.78144305806601e-06 NA NA NA hsa-miR-16-5p CALM1 0.934012514027655 4.85417898318515e-24 -0.376000013914611 2.23560119889328e-10 miRNATAP -0.133129468240625 7.69550310861395e-05 NA NA NA hsa-miR-186-5p CALM1 0.507217561043443 9.04455748270995e-10 -0.376000013914611 2.23560119889328e-10 mirMAP -0.147965505604452 0.000185461617706442 NA NA NA hsa-miR-193a-3p CALM1 0.849206638484406 3.68101781083335e-14 -0.376000013914611 2.23560119889328e-10 PITA;miRanda;miRNATAP -0.120325838368247 2.55496669776722e-05 NA NA NA hsa-miR-576-5p CALM1 1.06681109513983 5.69294424466526e-24 -0.376000013914611 2.23560119889328e-10 mirMAP -0.103189661590218 0.000457980739321235 NA NA NA hsa-miR-590-3p CALM1 1.13702599385212 3.53435739887793e-22 -0.376000013914611 2.23560119889328e-10 PITA;miRanda;mirMAP;miRNATAP -0.16556645853173 2.25561115600671e-10 NA NA NA hsa-miR-616-5p CALM1 0.913426384742148 3.78418389333709e-09 -0.376000013914611 2.23560119889328e-10 mirMAP -0.112290197812213 1.0296546987493e-07 NA NA NA hsa-miR-664a-3p CALM1 -0.019312777079624 0.825861598748857 -0.376000013914611 2.23560119889328e-10 mirMAP -0.126204595966489 0.00103692202354705 NA NA NA hsa-let-7a-3p CALM2 0.0677487960013088 0.460458477653989 -0.346709757185231 2.28174289376454e-11 miRNATAP -0.125420650805303 9.2322438941738e-05 NA NA NA hsa-miR-140-5p CALM2 0.504309496243674 3.09884038729031e-11 -0.346709757185231 2.28174289376454e-11 miRanda -0.12702358016825 0.000780721752102418 NA NA NA hsa-miR-338-5p CALM2 0.628429807914222 1.27575140717947e-06 -0.346709757185231 2.28174289376454e-11 miRNATAP -0.131423558672861 3.49399867954823e-09 NA NA NA hsa-miR-455-5p CALM2 0.773674551205946 2.12957541541474e-09 -0.346709757185231 2.28174289376454e-11 miRanda -0.139046314057923 1.25779640036215e-10 NA NA NA hsa-miR-542-3p CALM2 0.431147917094433 0.000254981247606435 -0.346709757185231 2.28174289376454e-11 miRanda -0.128177690040186 1.46585625299457e-07 NA NA NA hsa-miR-10b-3p CALM3 -0.8205021989966 7.84331443044781e-21 0.441805893602519 1.51708745446988e-15 miRNATAP -0.159210995887392 2.77292656966205e-06 NA NA NA hsa-miR-20a-3p CALML4 -0.112128426252791 0.346272219285942 0.595150409138897 8.03470579571609e-09 mirMAP -0.145894437156798 0.00295284629751755 NA NA NA hsa-miR-20b-5p CALML4 -1.30218163823367 6.87172815978149e-17 0.595150409138897 8.03470579571609e-09 mirMAP -0.114010047689153 0.00131652810389234 NA NA NA hsa-miR-577 CALML4 -1.48881999472397 7.03080165111147e-10 0.595150409138897 8.03470579571609e-09 PITA -0.1009707808708 1.54054282014743e-05 NA NA NA hsa-miR-126-5p CHUK 0.785607261431085 5.77058629454465e-13 -0.85746072421144 8.10744991906236e-38 MirTarget;mirMAP;miRNATAP -0.141478846302423 0.000105653732136013 NA NA NA hsa-miR-15a-5p CHUK 1.42663930007845 1.36006952074963e-57 -0.85746072421144 8.10744991906236e-38 miRNAWalker2_validate;miRTarBase;MirTarget -0.318418636879753 7.69752994687939e-18 NA NA NA hsa-miR-15b-5p CHUK 0.773001494057531 1.71784656078957e-16 -0.85746072421144 8.10744991906236e-38 MirTarget -0.225889800417735 5.44303807977529e-08 NA NA NA hsa-miR-16-5p CHUK 0.934012514027655 4.85417898318515e-24 -0.85746072421144 8.10744991906236e-38 miRNAWalker2_validate;miRTarBase;MirTarget -0.228889855351981 2.57589362388376e-08 NA NA NA hsa-miR-195-5p CHUK 0.346502644882604 0.0092562828415903 -0.85746072421144 8.10744991906236e-38 miRNAWalker2_validate;MirTarget -0.157478463247597 2.5847715765755e-07 NA NA NA hsa-miR-223-3p CHUK 1.23291409735619 1.07767240442694e-17 -0.85746072421144 8.10744991906236e-38 miRNAWalker2_validate;miRTarBase -0.158778742351017 2.71041182397134e-09 NA NA NA hsa-miR-23a-3p CHUK 0.761438723382355 4.09310879199257e-27 -0.85746072421144 8.10744991906236e-38 MirTarget -0.426829131699392 2.80265744990605e-16 NA NA NA hsa-miR-342-3p CHUK 1.4124432570595 1.07208971556131e-28 -0.85746072421144 8.10744991906236e-38 miRanda -0.194422482412743 1.9269792265026e-11 NA NA NA hsa-miR-497-5p CHUK 0.227757383708836 0.0600073987853074 -0.85746072421144 8.10744991906236e-38 MirTarget -0.149867793994567 9.91621768564792e-06 NA NA NA hsa-miR-590-3p CHUK 1.13702599385212 3.53435739887793e-22 -0.85746072421144 8.10744991906236e-38 miRanda;mirMAP -0.204551923277616 2.23702640558868e-10 NA NA NA hsa-miR-590-5p CHUK 0.709763558412506 1.11883921359361e-11 -0.85746072421144 8.10744991906236e-38 miRanda -0.177887016696357 2.94637831990317e-06 NA NA NA hsa-miR-125a-5p CSF1 -0.561874059994802 7.3931856356891e-13 0.828310197763411 2.57624161736929e-12 mirMAP -0.395873885403413 1.93692599708895e-06 NA NA NA hsa-miR-125b-5p CSF1 -0.825456421494266 2.13029877878434e-15 0.828310197763411 2.57624161736929e-12 mirMAP -0.218814994226492 0.000431474889918609 NA NA NA hsa-miR-149-5p CSF1 -1.95790336710741 8.46371715052367e-27 0.828310197763411 2.57624161736929e-12 MirTarget -0.135160675559984 6.55594095962956e-05 NA NA NA hsa-miR-20b-5p CSF1 -1.30218163823367 6.87172815978149e-17 0.828310197763411 2.57624161736929e-12 miRNATAP -0.143821877341533 0.000474036707352673 NA NA NA hsa-miR-27b-3p CSF1 -0.699527231242518 1.07356023759234e-15 0.828310197763411 2.57624161736929e-12 MirTarget;miRNATAP -0.317604540220119 1.76268674972506e-05 NA NA NA hsa-miR-30b-5p CSF1 -1.18330589477119 6.8341618466966e-27 0.828310197763411 2.57624161736929e-12 miRNAWalker2_validate -0.368050287582893 2.28262327368113e-11 NA NA NA hsa-miR-30c-5p CSF1 -1.08783070774238 2.02505402525786e-24 0.828310197763411 2.57624161736929e-12 miRNAWalker2_validate -0.336765548240368 5.7885490297714e-09 NA NA NA hsa-miR-429 CSF1 -2.16569233119434 2.66862243626443e-37 0.828310197763411 2.57624161736929e-12 PITA;miRanda;miRNATAP -0.223344874996782 9.46209764511635e-11 NA NA NA hsa-miR-532-3p CSF1 -1.759223962964 7.9077916669414e-40 0.828310197763411 2.57624161736929e-12 MirTarget;PITA -0.306939151835304 1.5169200994507e-12 NA NA NA hsa-miR-532-5p CSF1 -1.09700348358668 8.34836230254408e-26 0.828310197763411 2.57624161736929e-12 miRNATAP -0.431387311083581 8.94844012284901e-14 NA NA NA hsa-miR-199a-5p EFNA1 -1.64658415208633 1.01615659358973e-23 1.14383470621964 1.8843101516825e-20 miRanda -0.185373862936427 5.10111326697694e-06 NA NA NA hsa-miR-200b-3p EFNA1 -1.70383252137161 2.38979336321755e-30 1.14383470621964 1.8843101516825e-20 MirTarget;TargetScan -0.134966695411153 0.00228373190081269 NA NA NA hsa-miR-200c-3p EFNA1 -5.40303134829523 2.74173143360645e-94 1.14383470621964 1.8843101516825e-20 MirTarget;miRNATAP -0.181458532224935 1.2414606354021e-20 23065816 G A variant in miR 200c binding site of EFNA1 alters susceptibility to gastric cancer; Furthermore luciferase assays indicated EFNA1 as the target of hsa-miR-200c and rs12904 G > A change resulted in altered regulation of luciferase expression; Taken together these findings indicate that the miR-200c binding site SNP rs12904 G > A in the 3'UTR of EFNA1 can modulate EFNA1 expression and is associated with GC susceptibility gastric cancer hsa-miR-218-5p EFNA1 -0.81077534785501 3.0631582201951e-08 1.14383470621964 1.8843101516825e-20 miRNAWalker2_validate -0.167931355386355 0.000510592026626917 NA NA NA hsa-miR-30c-2-3p EFNA1 -1.28402709024345 6.77577627955178e-25 1.14383470621964 1.8843101516825e-20 MirTarget -0.283203639137564 9.62713819380543e-08 NA NA NA hsa-miR-324-3p EFNA1 -0.197662887871899 0.0298845059559819 1.14383470621964 1.8843101516825e-20 MirTarget;miRNATAP -0.438782043719366 2.65562302115535e-08 NA NA NA hsa-miR-335-5p EFNA1 -2.09515619961552 1.03765771499548e-25 1.14383470621964 1.8843101516825e-20 miRNAWalker2_validate -0.196438057726134 2.87933792785959e-09 NA NA NA hsa-miR-429 EFNA1 -2.16569233119434 2.66862243626443e-37 1.14383470621964 1.8843101516825e-20 MirTarget;PITA;miRanda;miRNATAP -0.13824050077292 0.000253644840903669 NA NA NA hsa-miR-491-5p EFNA1 -0.0898777415179634 0.533906535063567 1.14383470621964 1.8843101516825e-20 miRanda -0.146002082800429 0.00565137630060931 NA NA NA hsa-miR-96-5p EFNA1 -1.00223771166604 3.91564621567028e-06 1.14383470621964 1.8843101516825e-20 TargetScan -0.135031708537988 6.09037321028163e-05 NA NA NA hsa-miR-127-5p EFNA3 -1.33574359249785 5.73079880594981e-13 2.11061761081172 2.25783858294686e-44 PITA;miRNATAP -0.201615514388474 4.60899700091898e-05 NA NA NA hsa-miR-27b-3p EFNA3 -0.699527231242518 1.07356023759234e-15 2.11061761081172 2.25783858294686e-44 miRNATAP -0.628093568778092 1.30371688902415e-09 NA NA NA hsa-miR-30a-5p EFNA3 -0.778411951775343 2.73322451127932e-16 2.11061761081172 2.25783858294686e-44 MirTarget;mirMAP;miRNATAP -0.790764383259196 8.28517926023966e-18 NA NA NA hsa-miR-30b-5p EFNA3 -1.18330589477119 6.8341618466966e-27 2.11061761081172 2.25783858294686e-44 MirTarget;mirMAP -0.568614214193418 2.31510429385467e-13 NA NA NA hsa-miR-30c-5p EFNA3 -1.08783070774238 2.02505402525786e-24 2.11061761081172 2.25783858294686e-44 MirTarget;mirMAP;miRNATAP -0.674780052378266 2.73310713398252e-17 NA NA NA hsa-miR-30d-5p EFNA3 -0.202727675788184 0.00659067084745794 2.11061761081172 2.25783858294686e-44 MirTarget;mirMAP;miRNATAP -0.496216413934784 0.000122770761203762 NA NA NA hsa-miR-30e-5p EFNA3 -0.0905907245198101 0.21196704484334 2.11061761081172 2.25783858294686e-44 MirTarget;mirMAP -0.568298340264734 1.99551027034849e-05 NA NA NA hsa-miR-324-3p EFNA3 -0.197662887871899 0.0298845059559819 2.11061761081172 2.25783858294686e-44 MirTarget;PITA;miRNATAP -0.418443594951789 7.47362308436019e-05 NA NA NA hsa-miR-493-5p EFNA3 -1.03936667688502 3.71842205277243e-08 2.11061761081172 2.25783858294686e-44 MirTarget;miRNATAP -0.140694301737607 0.00617298880450261 NA NA NA hsa-miR-101-3p EFNA5 0.683973909682285 2.88573524246948e-15 -0.916153638664415 0.000753557067438735 miRNATAP -1.30644299979948 4.85092098666961e-16 NA NA NA hsa-miR-204-5p EFNA5 -1.67490789640238 9.14741888352476e-10 -0.916153638664415 0.000753557067438735 miRNATAP -0.453398164832293 4.85524883001676e-19 NA NA NA hsa-miR-28-5p EFNA5 0.461962042257226 3.32424690573327e-11 -0.916153638664415 0.000753557067438735 PITA;miRNATAP -0.774365773387412 0.000272291161753875 NA NA NA hsa-miR-338-3p EFNA5 0.906250377628867 2.76970900371139e-15 -0.916153638664415 0.000753557067438735 miRanda;miRNATAP -0.459437884692377 0.000261404591982066 NA NA NA hsa-miR-378a-3p EFNA5 0.287244802401236 0.0501155019984562 -0.916153638664415 0.000753557067438735 miRNATAP -0.407239578295669 7.00744079160358e-05 NA NA NA hsa-miR-378c EFNA5 0.755048315231594 3.56147090439556e-06 -0.916153638664415 0.000753557067438735 miRNATAP -0.455006523654393 5.8522084831463e-07 NA NA NA hsa-miR-421 EFNA5 0.313155739887734 0.020433534776003 -0.916153638664415 0.000753557067438735 mirMAP -0.309719389996976 0.00735760679037501 NA NA NA hsa-miR-592 EFNA5 2.6404220268798 8.81369998128794e-32 -0.916153638664415 0.000753557067438735 mirMAP;miRNATAP -0.197937206739904 0.0011674086024969 NA NA NA hsa-miR-590-3p EGF 1.13702599385212 3.53435739887793e-22 -6.49821423238405 1.01144352508784e-64 miRanda -1.60204014811855 6.03930462045536e-16 NA NA NA hsa-miR-629-3p EGF 1.09330044556689 2.9533160808356e-14 -6.49821423238405 1.01144352508784e-64 miRNATAP -0.695727142965681 6.88083628515494e-05 NA NA NA hsa-miR-141-3p EGFR -5.87110686537457 1.20877726722907e-85 1.04566425778521 6.25371695782468e-12 MirTarget -0.142272170209372 5.89271101342102e-11 26025929 Treatment with the EGFR inhibitor AG1478 or overexpression of miR141 blocked the activity of ERK downstream of EGFR and inhibited KLF8-depndent cell invasiveness proliferation and viability in cell culture and invasive growth and lung metastasis in nude mice metastasis breast cancer hsa-miR-188-5p EGFR -1.74586655806628 1.50431624674552e-28 1.04566425778521 6.25371695782468e-12 mirMAP -0.266112483430454 2.11374456409575e-07 NA NA NA hsa-miR-199a-3p EGFR -1.61607426368083 1.97964980193147e-26 1.04566425778521 6.25371695782468e-12 mirMAP -0.201778068439938 0.000117100162581278 NA NA NA hsa-miR-199b-3p EGFR -1.61804389801139 1.97668652730486e-26 1.04566425778521 6.25371695782468e-12 mirMAP -0.201560537599491 0.000116841770931786 NA NA NA hsa-miR-27b-3p EGFR -0.699527231242518 1.07356023759234e-15 1.04566425778521 6.25371695782468e-12 MirTarget;miRNATAP -0.42975046882661 5.91405803681307e-06 NA NA NA hsa-miR-335-5p EGFR -2.09515619961552 1.03765771499548e-25 1.04566425778521 6.25371695782468e-12 miRNAWalker2_validate -0.130866439253699 0.00119751239304092 NA NA NA hsa-miR-362-5p EGFR -2.72767654824605 1.34821749679113e-49 1.04566425778521 6.25371695782468e-12 mirMAP -0.275325520610269 1.67616170773246e-12 NA NA NA hsa-miR-375 EGFR -1.46468479447701 9.20596529469647e-07 1.04566425778521 6.25371695782468e-12 miRanda -0.116635350053781 3.88231671031593e-05 NA NA NA hsa-miR-501-5p EGFR -1.1103073934745 1.81589804886553e-16 1.04566425778521 6.25371695782468e-12 mirMAP -0.351439828127429 5.20411928127982e-09 NA NA NA hsa-miR-654-3p EGFR -1.07948413911035 1.47901771988248e-07 1.04566425778521 6.25371695782468e-12 mirMAP -0.119137373119274 0.00494226674362834 NA NA NA hsa-miR-125a-5p ELK1 -0.561874059994802 7.3931856356891e-13 0.336289227504367 2.16498541381608e-10 miRanda -0.132903172942065 0.0003317935240418 NA NA NA hsa-miR-429 ELK1 -2.16569233119434 2.66862243626443e-37 0.336289227504367 2.16498541381608e-10 miRNATAP -0.116863518433536 7.56828088575439e-15 NA NA NA hsa-miR-660-5p ELK1 -1.20833564582661 8.48975910642834e-23 0.336289227504367 2.16498541381608e-10 MirTarget -0.137463435624553 5.718488787413e-10 NA NA NA hsa-miR-193b-3p EPHA2 -0.273325765316079 0.104328826585392 0.368959129772177 0.00490074756518361 miRNAWalker2_validate -0.237291440313046 2.14068577455112e-08 NA NA NA hsa-miR-10a-5p ETS1 -1.17164272592931 4.86621098042279e-24 1.04709886262331 5.56713323792784e-20 miRNAWalker2_validate -0.229468550206213 1.76402389525268e-05 NA NA NA hsa-miR-125b-5p ETS1 -0.825456421494266 2.13029877878434e-15 1.04709886262331 5.56713323792784e-20 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.315536000795302 2.29448787900854e-07 21444677 miR 125b is methylated and functions as a tumor suppressor by regulating the ETS1 proto oncogene in human invasive breast cancer; We identified the ETS1 gene as a novel direct target of miR-125b; siRNA-mediated ETS1 knockdown phenocopied the effect of miR-125b in breast cell lines and ETS1 overexpression in invasive breast cancer tissues also correlated with poor patient prognosis worse prognosis breast cancer hsa-miR-141-3p ETS1 -5.87110686537457 1.20877726722907e-85 1.04709886262331 5.56713323792784e-20 mirMAP -0.166767570844055 1.68909901158844e-25 NA NA NA hsa-miR-193b-3p ETS1 -0.273325765316079 0.104328826585392 1.04709886262331 5.56713323792784e-20 miRNAWalker2_validate;miRTarBase -0.270657750194495 2.33844125069517e-12 20655737 CCND1 and ETS1 were revealed to be regulated by miR-193b directly liver cancer hsa-miR-199b-5p ETS1 -2.39483476763681 1.04659509514884e-17 1.04709886262331 5.56713323792784e-20 MirTarget;PITA;miRanda;miRNATAP -0.118429192843903 2.34500412136347e-07 NA NA NA hsa-miR-200a-3p ETS1 -1.43409013664263 2.00188483717828e-20 1.04709886262331 5.56713323792784e-20 mirMAP -0.239146159430993 1.92616543959321e-09 NA NA NA hsa-miR-200b-3p ETS1 -1.70383252137161 2.38979336321755e-30 1.04709886262331 5.56713323792784e-20 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.311956063431156 2.08563363589851e-15 NA NA NA hsa-miR-200c-3p ETS1 -5.40303134829523 2.74173143360645e-94 1.04709886262331 5.56713323792784e-20 MirTarget;miRNATAP -0.175545527708906 1.08850910312937e-22 NA NA NA hsa-miR-221-3p ETS1 0.337895669520713 0.0136448974691037 1.04709886262331 5.56713323792784e-20 miRTarBase;miRNATAP -0.214144731293191 9.86201242227819e-06 21711453 To close the loop we demonstrate ETS-1 as a direct target of miR-222 but not miR-221 showing the novel option of their uncoupled functions melanoma hsa-miR-222-3p ETS1 0.214811008033524 0.0965295551752457 1.04709886262331 5.56713323792784e-20 miRNAWalker2_validate;miRTarBase;miRNATAP -0.145913242588088 0.00499543429148985 21711453 Constitutive activation of the ETS 1 miR 222 circuitry in metastatic melanoma; We demonstrate that the proto-oncogene ETS-1 involved in the pathogenesis of cancers of different origin is a transcriptional regulator of miR-222 by direct binding to its promoter region; Differently from 293FT cells or early stage melanomas where unphosphorylated ETS-1 represses miR-222 transcription in metastatic melanoma the constitutively Thr-38 phosphorylated fraction of ETS-1 induces miR-222; To close the loop we demonstrate ETS-1 as a direct target of miR-222 but not miR-221 showing the novel option of their uncoupled functions staging melanoma hsa-miR-29a-5p ETS1 -0.519003718107105 1.03351148282116e-06 1.04709886262331 5.56713323792784e-20 MirTarget;miRNATAP -0.363869884718385 2.585299748818e-09 NA NA NA hsa-miR-30a-3p ETS1 -0.955360819934585 1.97009535429185e-20 1.04709886262331 5.56713323792784e-20 mirMAP -0.255148670524298 2.81966647672015e-05 NA NA NA hsa-miR-30c-5p ETS1 -1.08783070774238 2.02505402525786e-24 1.04709886262331 5.56713323792784e-20 miRNAWalker2_validate -0.297570181758341 2.49536415463351e-07 NA NA NA hsa-miR-30d-3p ETS1 -0.249777194282131 0.00235356711813496 1.04709886262331 5.56713323792784e-20 mirMAP -0.293454997520168 0.000334139534587632 NA NA NA hsa-miR-30e-3p ETS1 -0.205602546270795 0.00132666419729688 1.04709886262331 5.56713323792784e-20 mirMAP -0.287810554940749 0.00676243035024808 NA NA NA hsa-miR-335-3p ETS1 -1.36498175550207 6.84287752180534e-13 1.04709886262331 5.56713323792784e-20 mirMAP -0.137728312025737 4.60418102966032e-05 NA NA NA hsa-miR-362-3p ETS1 -0.753214251798232 3.0025661608035e-07 1.04709886262331 5.56713323792784e-20 miRanda -0.276949072577013 9.12037632464187e-10 NA NA NA hsa-miR-429 ETS1 -2.16569233119434 2.66862243626443e-37 1.04709886262331 5.56713323792784e-20 MirTarget;PITA;miRanda;miRNATAP -0.265136343681908 3.64812016606546e-15 NA NA NA hsa-miR-501-5p ETS1 -1.1103073934745 1.81589804886553e-16 1.04709886262331 5.56713323792784e-20 mirMAP -0.3059907844429 3.25400254454848e-11 NA NA NA hsa-miR-532-3p ETS1 -1.759223962964 7.9077916669414e-40 1.04709886262331 5.56713323792784e-20 MirTarget;PITA;miRNATAP -0.336847193717981 2.8355470047883e-15 NA NA NA hsa-miR-625-5p ETS1 0.153090549230629 0.330314026509869 1.04709886262331 5.56713323792784e-20 MirTarget -0.192386126284018 2.79393772889919e-05 NA NA NA hsa-miR-660-5p ETS1 -1.20833564582661 8.48975910642834e-23 1.04709886262331 5.56713323792784e-20 MirTarget -0.343738241808814 3.47986611127125e-12 NA NA NA hsa-miR-664a-3p ETS1 -0.019312777079624 0.825861598748857 1.04709886262331 5.56713323792784e-20 mirMAP -0.220319496328719 0.00432834197850264 NA NA NA hsa-miR-766-3p ETS1 -0.230617949950715 0.0566289375252083 1.04709886262331 5.56713323792784e-20 MirTarget -0.201677153969302 0.000265849477815655 NA NA NA hsa-miR-182-5p ETS2 -0.608710746044567 0.0025264935278104 0.265891071755249 0.00382882614608627 miRNATAP -0.164873739331067 1.30923082478515e-11 NA NA NA hsa-miR-221-3p ETS2 0.337895669520713 0.0136448974691037 0.265891071755249 0.00382882614608627 miRNATAP -0.171785862571788 2.83228256425327e-06 NA NA NA hsa-miR-222-3p ETS2 0.214811008033524 0.0965295551752457 0.265891071755249 0.00382882614608627 miRNATAP -0.167857369485567 1.77317844564376e-05 NA NA NA hsa-miR-30b-5p ETS2 -1.18330589477119 6.8341618466966e-27 0.265891071755249 0.00382882614608627 mirMAP -0.142176754274454 0.000819838701036453 NA NA NA hsa-miR-30e-5p ETS2 -0.0905907245198101 0.21196704484334 0.265891071755249 0.00382882614608627 mirMAP -0.228763340739883 0.00128864763848188 NA NA NA hsa-let-7e-5p FASLG -0.727009689927955 1.30690859412163e-11 3.49526870659822 3.0591043026913e-47 miRNATAP -0.956759956622149 2.07254587441987e-12 NA NA NA hsa-let-7g-5p FASLG -0.739744008507763 1.07979566264383e-14 3.49526870659822 3.0591043026913e-47 miRNATAP -0.527566684352497 0.00071592111786537 NA NA NA hsa-miR-199a-5p FASLG -1.64658415208633 1.01615659358973e-23 3.49526870659822 3.0591043026913e-47 miRanda -0.587327373538791 5.90733830602172e-12 NA NA NA hsa-miR-362-3p FASLG -0.753214251798232 3.0025661608035e-07 3.49526870659822 3.0591043026913e-47 miRanda -0.346233134453532 0.00119742349456323 NA NA NA hsa-miR-126-5p FGF1 0.785607261431085 5.77058629454465e-13 -3.80115931488584 6.45925676739727e-49 mirMAP -0.412699157217257 0.00526602775124141 NA NA NA hsa-miR-146b-3p FGF1 1.20941495066078 2.12939149602665e-10 -3.80115931488584 6.45925676739727e-49 miRNATAP -0.412681804700488 8.7577650210875e-07 NA NA NA hsa-miR-16-1-3p FGF1 1.51429140700091 3.17219833254498e-37 -3.80115931488584 6.45925676739727e-49 mirMAP -0.964767375204906 2.41440232347677e-15 NA NA NA hsa-miR-186-5p FGF1 0.507217561043443 9.04455748270995e-10 -3.80115931488584 6.45925676739727e-49 mirMAP -1.1691556044543 1.5936381390255e-09 NA NA NA hsa-miR-18a-5p FGF1 0.936704393213466 1.05064580570579e-10 -3.80115931488584 6.45925676739727e-49 MirTarget -0.380773292559268 0.00062635862331619 NA NA NA hsa-miR-193a-3p FGF1 0.849206638484406 3.68101781083335e-14 -3.80115931488584 6.45925676739727e-49 PITA -0.799485713529985 1.34176070169954e-08 NA NA NA hsa-miR-21-5p FGF1 2.51462371613332 3.30620591950316e-66 -3.80115931488584 6.45925676739727e-49 MirTarget -1.0333718022015 1.64441254488335e-35 NA NA NA hsa-miR-2355-5p FGF1 1.57515081110162 3.54962327490702e-48 -3.80115931488584 6.45925676739727e-49 MirTarget -1.06613568021987 4.20053987792956e-17 NA NA NA hsa-miR-28-5p FGF1 0.461962042257226 3.32424690573327e-11 -3.80115931488584 6.45925676739727e-49 miRanda -0.947270161202561 5.17246250727041e-05 NA NA NA hsa-miR-320a FGF1 0.412740558379182 2.02929519701706e-05 -3.80115931488584 6.45925676739727e-49 miRanda -0.542494284439551 0.00150132216990968 NA NA NA hsa-miR-330-5p FGF1 1.44960468659754 2.12131210588035e-45 -3.80115931488584 6.45925676739727e-49 miRanda;miRNATAP -1.30237436907411 7.22656393944219e-23 NA NA NA hsa-miR-374a-3p FGF1 1.13863935833993 2.79089304015401e-44 -3.80115931488584 6.45925676739727e-49 mirMAP -1.40971713192021 1.79713277496189e-16 NA NA NA hsa-miR-3913-5p FGF1 0.136365354811444 0.24239516424369 -3.80115931488584 6.45925676739727e-49 mirMAP -0.458269193077043 0.00234831890309927 NA NA NA hsa-miR-484 FGF1 0.571987778099603 9.67278224458421e-10 -3.80115931488584 6.45925676739727e-49 MirTarget;PITA;miRNATAP -0.539151528053616 0.00200972026686984 NA NA NA hsa-miR-550a-5p FGF1 0.764341426122997 7.62129848116256e-09 -3.80115931488584 6.45925676739727e-49 MirTarget -0.542780642335613 1.80477226060982e-05 NA NA NA hsa-miR-576-5p FGF1 1.06681109513983 5.69294424466526e-24 -3.80115931488584 6.45925676739727e-49 PITA;mirMAP -1.26887442737172 6.80528442258741e-20 NA NA NA hsa-miR-590-5p FGF1 0.709763558412506 1.11883921359361e-11 -3.80115931488584 6.45925676739727e-49 MirTarget;miRanda;miRNATAP -0.760247687860989 6.80195819553776e-07 NA NA NA hsa-miR-629-5p FGF1 1.73389921851483 5.39614356468007e-48 -3.80115931488584 6.45925676739727e-49 MirTarget -1.38540287626161 3.01408249241889e-38 NA NA NA hsa-let-7e-5p FGF11 -0.727009689927955 1.30690859412163e-11 2.23617192158805 1.8788982620777e-26 mirMAP;miRNATAP -0.32446922393154 0.00441188606836517 NA NA NA hsa-let-7g-5p FGF11 -0.739744008507763 1.07979566264383e-14 2.23617192158805 1.8788982620777e-26 mirMAP;miRNATAP -0.714675969532457 9.32950813786375e-09 NA NA NA hsa-miR-10a-5p FGF11 -1.17164272592931 4.86621098042279e-24 2.23617192158805 1.8788982620777e-26 mirMAP -0.519537627190446 1.90326383611477e-07 NA NA NA hsa-miR-125a-5p FGF11 -0.561874059994802 7.3931856356891e-13 2.23617192158805 1.8788982620777e-26 mirMAP -0.491473322603107 0.00168737579895867 NA NA NA hsa-miR-125b-5p FGF11 -0.825456421494266 2.13029877878434e-15 2.23617192158805 1.8788982620777e-26 mirMAP -0.790229628434622 2.28241804372165e-12 NA NA NA hsa-miR-193b-3p FGF11 -0.273325765316079 0.104328826585392 2.23617192158805 1.8788982620777e-26 miRNAWalker2_validate -0.264997262620483 0.000378170532610284 NA NA NA hsa-miR-199a-5p FGF11 -1.64658415208633 1.01615659358973e-23 2.23617192158805 1.8788982620777e-26 miRanda -0.365321328288127 2.0503722571563e-07 NA NA NA hsa-miR-199b-5p FGF11 -2.39483476763681 1.04659509514884e-17 2.23617192158805 1.8788982620777e-26 miRanda -0.267087192579251 3.70589364602002e-10 NA NA NA hsa-miR-217 FGF11 -1.32414431829977 4.20138196453017e-06 2.23617192158805 1.8788982620777e-26 PITA;miRanda -0.217410327744056 3.17577593872614e-07 NA NA NA hsa-miR-324-5p FGF11 -0.487750893426456 3.74472736457965e-05 2.23617192158805 1.8788982620777e-26 miRanda -0.440327954994482 2.67066434439899e-05 NA NA NA hsa-miR-335-5p FGF11 -2.09515619961552 1.03765771499548e-25 2.23617192158805 1.8788982620777e-26 miRNAWalker2_validate;mirMAP -0.361050653609898 2.98033784759218e-10 NA NA NA hsa-miR-532-3p FGF11 -1.759223962964 7.9077916669414e-40 2.23617192158805 1.8788982620777e-26 mirMAP -0.722489323765386 5.00428763930247e-20 NA NA NA hsa-miR-107 FGF12 0.140046250553248 0.0943611632552367 -0.544326533476572 0.000268476484930876 miRanda -0.308318107900707 0.0020791655765071 NA NA NA hsa-miR-142-5p FGF12 1.88417391525707 1.2096808039882e-27 -0.544326533476572 0.000268476484930876 miRNATAP -0.318634287216316 6.22273374967518e-14 NA NA NA hsa-miR-17-5p FGF12 0.494260110870015 3.8348005261e-09 -0.544326533476572 0.000268476484930876 TargetScan -0.263868289343099 0.00688746603358349 NA NA NA hsa-miR-2355-3p FGF12 1.32757890426926 1.88016636795886e-18 -0.544326533476572 0.000268476484930876 MirTarget;miRNATAP -0.153811131758858 0.00389207620799374 NA NA NA hsa-miR-342-3p FGF12 1.4124432570595 1.07208971556131e-28 -0.544326533476572 0.000268476484930876 miRanda -0.356290596206616 1.17638486726232e-09 NA NA NA hsa-miR-455-5p FGF12 0.773674551205946 2.12957541541474e-09 -0.544326533476572 0.000268476484930876 miRanda -0.253534570625561 4.85862913572717e-05 NA NA NA hsa-miR-576-5p FGF12 1.06681109513983 5.69294424466526e-24 -0.544326533476572 0.000268476484930876 mirMAP -0.242190473439388 0.000932815704136755 NA NA NA hsa-miR-590-3p FGF12 1.13702599385212 3.53435739887793e-22 -0.544326533476572 0.000268476484930876 mirMAP -0.41088644924644 2.2750931713891e-10 NA NA NA hsa-miR-616-5p FGF12 0.913426384742148 3.78418389333709e-09 -0.544326533476572 0.000268476484930876 MirTarget -0.148821746829177 0.00515708784404577 NA NA NA hsa-miR-142-5p FGF13 1.88417391525707 1.2096808039882e-27 -0.355285378300594 0.0111820560270456 PITA -0.114950681929534 0.00514428395065014 NA NA NA hsa-miR-340-5p FGF13 1.14479851941741 2.91936881701444e-15 -0.355285378300594 0.0111820560270456 MirTarget -0.187712863175925 0.000225631107920348 NA NA NA hsa-miR-455-5p FGF13 0.773674551205946 2.12957541541474e-09 -0.355285378300594 0.0111820560270456 PITA;miRanda -0.213004300489336 0.000261097737029612 NA NA NA hsa-miR-7-1-3p FGF13 0.544601828025304 5.33830451326047e-07 -0.355285378300594 0.0111820560270456 MirTarget;mirMAP -0.279000874186576 6.71817165068062e-05 NA NA NA hsa-miR-103a-3p FGF18 0.779373475434461 7.37867196796994e-20 -1.06341529740156 1.38965890583684e-07 miRNATAP -0.447891739165942 0.00037020775263271 NA NA NA hsa-miR-107 FGF18 0.140046250553248 0.0943611632552367 -1.06341529740156 1.38965890583684e-07 miRNATAP -0.57929754380422 2.05446408358056e-05 NA NA NA hsa-miR-15a-5p FGF18 1.42663930007845 1.36006952074963e-57 -1.06341529740156 1.38965890583684e-07 miRNATAP -0.534405765807597 4.02497295632232e-07 NA NA NA hsa-miR-16-5p FGF18 0.934012514027655 4.85417898318515e-24 -1.06341529740156 1.38965890583684e-07 miRNATAP -0.347307673451457 0.00249430704083827 NA NA NA hsa-miR-21-5p FGF18 2.51462371613332 3.30620591950316e-66 -1.06341529740156 1.38965890583684e-07 miRNATAP -0.240173567040242 0.000131541472622255 NA NA NA hsa-miR-330-5p FGF18 1.44960468659754 2.12131210588035e-45 -1.06341529740156 1.38965890583684e-07 PITA;miRanda;miRNATAP -0.339622639535814 0.000407996785668723 NA NA NA hsa-miR-421 FGF18 0.313155739887734 0.020433534776003 -1.06341529740156 1.38965890583684e-07 miRanda -0.270977518576723 0.00177389655223298 NA NA NA hsa-miR-590-5p FGF18 0.709763558412506 1.11883921359361e-11 -1.06341529740156 1.38965890583684e-07 miRanda;miRNATAP -0.299844534788332 0.00454562101475503 NA NA NA hsa-let-7a-3p FGF2 0.0677487960013088 0.460458477653989 -0.589674911482514 4.9097503791125e-05 mirMAP -0.413855026311993 2.64122269531956e-06 NA NA NA hsa-miR-107 FGF2 0.140046250553248 0.0943611632552367 -0.589674911482514 4.9097503791125e-05 MirTarget;PITA;miRanda;miRNATAP -0.252364961790113 0.00988319837104476 NA NA NA hsa-miR-146a-5p FGF2 1.04938133739924 7.51013231709992e-12 -0.589674911482514 4.9097503791125e-05 mirMAP -0.210539194206361 3.35191542749017e-05 NA NA NA hsa-miR-15a-5p FGF2 1.42663930007845 1.36006952074963e-57 -0.589674911482514 4.9097503791125e-05 MirTarget;miRNATAP -0.255449530855187 0.000776459741728151 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-3p FGF2 1.49422666971434 5.44139893275088e-29 -0.589674911482514 4.9097503791125e-05 mirMAP -0.216697138822269 8.55843255884349e-05 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-1-3p FGF2 1.51429140700091 3.17219833254498e-37 -0.589674911482514 4.9097503791125e-05 mirMAP -0.163232052977134 0.00821869739056501 NA NA NA hsa-miR-16-2-3p FGF2 1.3046118743965 4.17207934608428e-19 -0.589674911482514 4.9097503791125e-05 mirMAP -0.186446224772941 0.000351536882101309 NA NA NA hsa-miR-16-5p FGF2 0.934012514027655 4.85417898318515e-24 -0.589674911482514 4.9097503791125e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.242955350739253 0.00300895920388753 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-192-5p FGF2 0.442478872410106 0.0669238175123954 -0.589674911482514 4.9097503791125e-05 miRNAWalker2_validate -0.102614170997363 0.00212550043678563 NA NA NA hsa-miR-19b-1-5p FGF2 0.66692013055553 1.55789130176287e-09 -0.589674911482514 4.9097503791125e-05 mirMAP -0.213543395777736 0.00295255172655819 NA NA NA hsa-miR-21-5p FGF2 2.51462371613332 3.30620591950316e-66 -0.589674911482514 4.9097503791125e-05 mirMAP -0.126618960975775 0.00490413708016251 NA NA NA hsa-miR-215-5p FGF2 1.57223951497888 6.18833867819653e-10 -0.589674911482514 4.9097503791125e-05 miRNAWalker2_validate -0.15555129616708 3.63011104027706e-07 NA NA NA hsa-miR-32-5p FGF2 0.407826130035097 7.26884631998646e-06 -0.589674911482514 4.9097503791125e-05 miRNAWalker2_validate -0.39260283335843 7.71884095801517e-06 NA NA NA hsa-miR-338-5p FGF2 0.628429807914222 1.27575140717947e-06 -0.589674911482514 4.9097503791125e-05 mirMAP -0.215263032074881 0.000575910517976575 NA NA NA hsa-miR-361-5p FGF2 0.0514169367202078 0.382929376393199 -0.589674911482514 4.9097503791125e-05 mirMAP -0.372320972807354 0.00839299302616162 NA NA NA hsa-miR-374a-3p FGF2 1.13863935833993 2.79089304015401e-44 -0.589674911482514 4.9097503791125e-05 mirMAP -0.301198297479784 0.0005177785699223 NA NA NA hsa-miR-374b-5p FGF2 0.0804104684417872 0.365593963035077 -0.589674911482514 4.9097503791125e-05 mirMAP -0.414924088923791 5.30808312664893e-06 NA NA NA hsa-miR-590-3p FGF2 1.13702599385212 3.53435739887793e-22 -0.589674911482514 4.9097503791125e-05 miRanda;mirMAP -0.223542377598034 0.000531270043941063 NA NA NA hsa-miR-590-5p FGF2 0.709763558412506 1.11883921359361e-11 -0.589674911482514 4.9097503791125e-05 miRanda;mirMAP -0.262470036573759 0.000472851744537926 NA NA NA hsa-miR-338-3p FGF5 0.906250377628867 2.76970900371139e-15 -1.83723658792888 9.61171733928648e-07 miRanda -0.523502317862385 0.00291245665472794 NA NA NA hsa-miR-455-5p FGF5 0.773674551205946 2.12957541541474e-09 -1.83723658792888 9.61171733928648e-07 miRanda -0.445706621017696 0.00510035663278383 NA NA NA hsa-miR-126-5p FGF7 0.785607261431085 5.77058629454465e-13 -1.97624310317764 2.86806708934501e-20 miRNATAP -0.35417145796188 0.00148560446741828 NA NA NA hsa-miR-155-5p FGF7 3.26274490570809 5.06841441826518e-51 -1.97624310317764 2.86806708934501e-20 miRNAWalker2_validate;miRTarBase;mirMAP;miRNATAP -0.209194847453416 1.86189427308698e-05 NA NA NA hsa-miR-15a-5p FGF7 1.42663930007845 1.36006952074963e-57 -1.97624310317764 2.86806708934501e-20 miRTarBase;miRNATAP -0.847236705144023 1.19914061552758e-13 NA NA NA hsa-miR-15b-5p FGF7 0.773001494057531 1.71784656078957e-16 -1.97624310317764 2.86806708934501e-20 miRNATAP -0.675844673945504 9.2634659069312e-08 NA NA NA hsa-miR-16-1-3p FGF7 1.51429140700091 3.17219833254498e-37 -1.97624310317764 2.86806708934501e-20 mirMAP -0.479652584917845 3.96398023440139e-07 NA NA NA hsa-miR-16-2-3p FGF7 1.3046118743965 4.17207934608428e-19 -1.97624310317764 2.86806708934501e-20 mirMAP -0.22562888615642 0.00555719154096863 NA NA NA hsa-miR-16-5p FGF7 0.934012514027655 4.85417898318515e-24 -1.97624310317764 2.86806708934501e-20 miRNATAP -0.562305081893864 8.31032538296145e-06 NA NA NA hsa-miR-20a-5p FGF7 0.702602695798242 4.06372887613329e-13 -1.97624310317764 2.86806708934501e-20 miRNAWalker2_validate -0.56349110002559 6.1764049927491e-06 NA NA NA hsa-miR-27a-3p FGF7 0.558934437526245 1.44256383086177e-12 -1.97624310317764 2.86806708934501e-20 MirTarget -0.491043390020319 0.00156230248699803 NA NA NA hsa-miR-340-5p FGF7 1.14479851941741 2.91936881701444e-15 -1.97624310317764 2.86806708934501e-20 mirMAP -0.369328887879201 7.08248065738976e-06 NA NA NA hsa-miR-374a-3p FGF7 1.13863935833993 2.79089304015401e-44 -1.97624310317764 2.86806708934501e-20 miRNATAP -0.593508361010668 9.50745159268841e-06 NA NA NA hsa-miR-452-5p FGF7 2.05325688842141 2.82238393643084e-40 -1.97624310317764 2.86806708934501e-20 mirMAP -0.373676554420803 1.20947812660623e-07 NA NA NA hsa-miR-455-3p FGF7 0.171798655137046 0.261841668213493 -1.97624310317764 2.86806708934501e-20 PITA;miRNATAP -0.304968993458052 0.00019698398945574 NA NA NA hsa-miR-486-5p FGF7 1.16748143760361 1.68410465883829e-08 -1.97624310317764 2.86806708934501e-20 MirTarget;miRanda -0.214937151224756 0.000278538413773526 NA NA NA hsa-miR-542-3p FGF7 0.431147917094433 0.000254981247606435 -1.97624310317764 2.86806708934501e-20 miRanda -0.315059448630938 0.00298991790572798 NA NA NA hsa-miR-590-3p FGF7 1.13702599385212 3.53435739887793e-22 -1.97624310317764 2.86806708934501e-20 PITA;miRanda;mirMAP;miRNATAP -0.368850958190117 0.000229960701103488 NA NA NA hsa-miR-590-5p FGF7 0.709763558412506 1.11883921359361e-11 -1.97624310317764 2.86806708934501e-20 PITA;miRanda -0.348010220978055 0.00292627950694944 NA NA NA hsa-miR-616-5p FGF7 0.913426384742148 3.78418389333709e-09 -1.97624310317764 2.86806708934501e-20 mirMAP -0.298120733208393 0.000201559767102017 NA NA NA hsa-miR-7-1-3p FGF7 0.544601828025304 5.33830451326047e-07 -1.97624310317764 2.86806708934501e-20 mirMAP -0.43572294285412 0.000128343842961541 NA NA NA hsa-miR-132-3p FGF9 0.291409674711894 0.000912684337101876 -7.89303410861971 6.51626529576473e-68 mirMAP -1.49278300216127 2.05673100310755e-05 NA NA NA hsa-miR-140-3p FGF9 0.989350547007025 6.14964028267239e-25 -7.89303410861971 6.51626529576473e-68 miRNATAP -2.36734754388086 1.68509808638843e-16 NA NA NA hsa-miR-140-5p FGF9 0.504309496243674 3.09884038729031e-11 -7.89303410861971 6.51626529576473e-68 miRNAWalker2_validate;PITA;miRanda;miRNATAP -2.14696810755974 4.91581299417391e-08 NA NA NA hsa-miR-142-3p FGF9 1.88928758773299 2.72985643829893e-22 -7.89303410861971 6.51626529576473e-68 miRanda -1.28510812329466 4.80178741191123e-20 NA NA NA hsa-miR-142-5p FGF9 1.88417391525707 1.2096808039882e-27 -7.89303410861971 6.51626529576473e-68 mirMAP -1.5849190428124 2.31403871037857e-25 NA NA NA hsa-miR-143-3p FGF9 0.544259011512089 1.71102635165867e-05 -7.89303410861971 6.51626529576473e-68 miRNATAP -0.918749044179476 0.000137890724045419 NA NA NA hsa-miR-155-5p FGF9 3.26274490570809 5.06841441826518e-51 -7.89303410861971 6.51626529576473e-68 miRNATAP -1.45574467015398 9.91351979840903e-43 NA NA NA hsa-miR-15a-5p FGF9 1.42663930007845 1.36006952074963e-57 -7.89303410861971 6.51626529576473e-68 miRNATAP -3.59565285580255 6.46550650472585e-46 NA NA NA hsa-miR-15b-5p FGF9 0.773001494057531 1.71784656078957e-16 -7.89303410861971 6.51626529576473e-68 miRNATAP -2.62381325572957 2.49932882811215e-18 NA NA NA hsa-miR-16-2-3p FGF9 1.3046118743965 4.17207934608428e-19 -7.89303410861971 6.51626529576473e-68 mirMAP -1.47968858497529 1.56368473036667e-14 NA NA NA hsa-miR-16-5p FGF9 0.934012514027655 4.85417898318515e-24 -7.89303410861971 6.51626529576473e-68 miRNATAP -2.93941999209394 8.19865698545329e-24 NA NA NA hsa-miR-181a-5p FGF9 1.11111114875339 3.97880443756442e-29 -7.89303410861971 6.51626529576473e-68 mirMAP -3.01683259489948 6.2935151356822e-31 NA NA NA hsa-miR-181b-5p FGF9 1.49054296272357 3.69051660739368e-41 -7.89303410861971 6.51626529576473e-68 mirMAP -2.88764658364589 2.42529744328292e-40 NA NA NA hsa-miR-181c-5p FGF9 0.762784646696248 4.48373118147729e-10 -7.89303410861971 6.51626529576473e-68 mirMAP -0.974034125284438 7.24711889757936e-05 NA NA NA hsa-miR-186-5p FGF9 0.507217561043443 9.04455748270995e-10 -7.89303410861971 6.51626529576473e-68 mirMAP -2.38550261599293 2.61095557708383e-11 NA NA NA hsa-miR-195-3p FGF9 0.808592887366705 6.8151241038711e-09 -7.89303410861971 6.51626529576473e-68 mirMAP;miRNATAP -1.1840868478066 3.6353294065925e-08 NA NA NA hsa-miR-195-5p FGF9 0.346502644882604 0.0092562828415903 -7.89303410861971 6.51626529576473e-68 miRNATAP -0.834949314691814 0.000307067445099101 NA NA NA hsa-miR-320a FGF9 0.412740558379182 2.02929519701706e-05 -7.89303410861971 6.51626529576473e-68 mirMAP;miRNATAP -1.74376828066047 2.39519261181127e-08 NA NA NA hsa-miR-320b FGF9 0.300497419754843 0.0245219177384172 -7.89303410861971 6.51626529576473e-68 mirMAP;miRNATAP -0.829189781584702 0.000327781913785607 NA NA NA hsa-miR-330-5p FGF9 1.44960468659754 2.12131210588035e-45 -7.89303410861971 6.51626529576473e-68 miRanda;miRNATAP -3.09466572534346 1.25369400690336e-40 NA NA NA hsa-miR-338-3p FGF9 0.906250377628867 2.76970900371139e-15 -7.89303410861971 6.51626529576473e-68 PITA;miRanda;miRNATAP -1.75095892002454 3.06094850352792e-12 NA NA NA hsa-miR-338-5p FGF9 0.628429807914222 1.27575140717947e-06 -7.89303410861971 6.51626529576473e-68 miRNATAP -1.18083105634736 6.1007334937809e-07 NA NA NA hsa-miR-374a-5p FGF9 0.543061152108237 2.19403097299769e-14 -7.89303410861971 6.51626529576473e-68 mirMAP -3.20984621216012 2.95766906510555e-15 NA NA NA hsa-miR-450b-5p FGF9 0.404819502355575 0.00357671373841274 -7.89303410861971 6.51626529576473e-68 mirMAP;miRNATAP -0.585609878563624 0.00843223916148081 NA NA NA hsa-miR-455-5p FGF9 0.773674551205946 2.12957541541474e-09 -7.89303410861971 6.51626529576473e-68 miRanda -2.01014500445414 1.06761241000351e-19 NA NA NA hsa-miR-486-5p FGF9 1.16748143760361 1.68410465883829e-08 -7.89303410861971 6.51626529576473e-68 miRanda;miRNATAP -0.665125032723195 4.27507860555687e-06 NA NA NA hsa-miR-590-3p FGF9 1.13702599385212 3.53435739887793e-22 -7.89303410861971 6.51626529576473e-68 miRanda;mirMAP -2.01793594346917 1.06482309489454e-17 NA NA NA hsa-miR-590-5p FGF9 0.709763558412506 1.11883921359361e-11 -7.89303410861971 6.51626529576473e-68 miRanda -1.77139537220211 2.97618057411205e-10 NA NA NA hsa-miR-106a-5p FGFR1 -0.830908656792615 2.67547872901508e-10 -0.0525238824904433 0.558795583881832 mirMAP -0.122312677751729 0.000796948557217005 NA NA NA hsa-miR-106b-5p FGFR1 1.07509411417907 2.11739194181878e-36 -0.0525238824904433 0.558795583881832 mirMAP -0.172801838537576 0.000867031520570411 NA NA NA hsa-miR-15a-5p FGFR1 1.42663930007845 1.36006952074963e-57 -0.0525238824904433 0.558795583881832 miRNATAP -0.155174390546639 0.0008156091626643 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-5p FGFR1 0.934012514027655 4.85417898318515e-24 -0.0525238824904433 0.558795583881832 miRTarBase;miRNATAP -0.147661895787119 0.00311233392470522 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-200a-5p FGFR1 -1.36295040293874 1.31587720312419e-22 -0.0525238824904433 0.558795583881832 mirMAP -0.11714731259483 0.000383511996434836 NA NA NA hsa-miR-455-5p FGFR1 0.773674551205946 2.12957541541474e-09 -0.0525238824904433 0.558795583881832 miRanda -0.135338346114823 0.000273762518549006 NA NA NA hsa-miR-744-5p FGFR1 -0.348985243196771 0.000187889982228835 -0.0525238824904433 0.558795583881832 miRNAWalker2_validate -0.146388006709524 0.00556141272629985 NA NA NA hsa-miR-93-5p FGFR1 1.37365940377595 2.37567548683245e-46 -0.0525238824904433 0.558795583881832 mirMAP -0.12587058194249 0.00478965048434933 NA NA NA hsa-let-7f-1-3p FGFR2 0.477913872379336 4.46669616865068e-05 -1.51421563934131 8.18226435279308e-18 mirMAP -0.459956632895475 7.61285152724438e-07 NA NA NA hsa-miR-107 FGFR2 0.140046250553248 0.0943611632552367 -1.51421563934131 8.18226435279308e-18 PITA;miRanda -0.437925872253477 0.000383864151891506 NA NA NA hsa-miR-146b-5p FGFR2 1.40714170253819 2.9559871816487e-12 -1.51421563934131 8.18226435279308e-18 miRanda -0.195329005140458 6.1791587336115e-05 NA NA NA hsa-miR-186-5p FGFR2 0.507217561043443 9.04455748270995e-10 -1.51421563934131 8.18226435279308e-18 miRNAWalker2_validate -0.658270917605348 3.90698190892792e-08 NA NA NA hsa-miR-193a-3p FGFR2 0.849206638484406 3.68101781083335e-14 -1.51421563934131 8.18226435279308e-18 miRanda -0.301820482762674 0.000602194355705739 NA NA NA hsa-miR-19b-1-5p FGFR2 0.66692013055553 1.55789130176287e-09 -1.51421563934131 8.18226435279308e-18 miRNAWalker2_validate;miRTarBase -0.282031805724181 0.00192425817708402 NA NA NA hsa-miR-330-5p FGFR2 1.44960468659754 2.12131210588035e-45 -1.51421563934131 8.18226435279308e-18 miRanda -0.664891022598281 1.62616877464583e-15 NA NA NA hsa-miR-338-3p FGFR2 0.906250377628867 2.76970900371139e-15 -1.51421563934131 8.18226435279308e-18 miRanda;miRNATAP -0.293371462535014 0.000601750978017947 NA NA NA hsa-miR-423-3p FGFR2 0.460506077888547 3.44680149368459e-09 -1.51421563934131 8.18226435279308e-18 PITA;miRNATAP -0.489761504946408 0.000152390546115974 NA NA NA hsa-miR-590-3p FGFR2 1.13702599385212 3.53435739887793e-22 -1.51421563934131 8.18226435279308e-18 miRanda -0.563054904471333 1.30676539898336e-12 NA NA NA hsa-miR-100-5p FGFR3 0.11286733449117 0.464055070627288 -0.904654482736578 8.36824652739321e-07 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.313875417771344 2.1395862881888e-06 25344675;26604796;26018508;23778527 MicroRNA 100 regulates pancreatic cancer cells growth and sensitivity to chemotherapy through targeting FGFR3; The predicted target of miR-100 fibroblast growth factor receptor 3 FGFR3 was downregulated by siRNA to examine its effect on pancreatic cancer cells; Luciferase essay showed FGFR3 was direct target of miR-100; FGFR3 was significantly downregulated by overexpressing miR-100 in pancreatic cancer cells and knocking down FGFR3 by siRNA exerted similar effect as miR-100; Our study demonstrated that miR-100 played an important role in pancreatic cancer development possibly through targeting FGFR3;Overexpression of miR 100 inhibits cell proliferation migration and chemosensitivity in human glioblastoma through FGFR3; Expression of fibroblast growth factor receptor 3 FGFR3 the bioinformatically predicted target of miR-100 was examined by Western blot in glioblastoma; FGFR3 was directly regulated by miR-100 in glioblastoma; Ectopically overexpressing FGFR3 was able to ameliorate the anticancer effects of upregulation of miR-100 on glioblastoma growth migration and chemosensitivity; Overexpressing miR-100 had anticancer effects on glioblastoma likely through regulation of FGFR3;Overexpression of miR 100 inhibits growth of osteosarcoma through FGFR3; Here we reported significantly higher levels of fibroblast growth factor receptor 3 FGFR3 and significantly lower levels of miR-100 in the OS specimen compared to those in the paired normal bone tissues; Bioinformatics analysis and luciferase reporter assay suggest that miR-100 binds to the 3'UTR of FGFR3 mRNA to prevent its translation; Taken together our data demonstrate that miR-100 may inhibit the growth of OS through FGFR3;Hypoxia regulates FGFR3 expression via HIF 1α and miR 100 and contributes to cell survival in non muscle invasive bladder cancer; We have previously investigated the role of microRNAs in bladder cancer and have shown that FGFR3 is a target of miR-100; In this study we investigated the effects of hypoxia on miR-100 and FGFR3 expression and the link between miR-100 and FGFR3 in hypoxia; Bladder cancer cell lines were exposed to normoxic or hypoxic conditions and examined for the expression of FGFR3 by quantitative PCR qPCR and western blotting and miR-100 by qPCR; The effect of FGFR3 and miR-100 on cell viability in two-dimensional 2-D and three-dimensional 3-D was examined by transfecting siRNA or mimic-100 respectively; Increased FGFR3 was also in part dependent on miR-100 levels which decreased in hypoxia; Hypoxia in part via suppression of miR-100 induces FGFR3 expression in bladder cancer both of which have an important role in maintaining cell viability under conditions of stress ;;;poor survival pancreatic cancer;glioblastoma;sarcoma;bladder cancer hsa-miR-142-3p FGFR3 1.88928758773299 2.72985643829893e-22 -0.904654482736578 8.36824652739321e-07 miRanda -0.280059637101442 7.39044053762073e-09 NA NA NA hsa-miR-19a-3p FGFR3 0.722913586880779 2.76301458932381e-10 -0.904654482736578 8.36824652739321e-07 mirMAP -0.264260219813925 0.00257802543229013 NA NA NA hsa-miR-590-3p FGFR3 1.13702599385212 3.53435739887793e-22 -0.904654482736578 8.36824652739321e-07 miRanda -0.407978649398992 5.16183297718401e-07 NA NA NA hsa-miR-106a-5p FLT1 -0.830908656792615 2.67547872901508e-10 1.81517574635769 1.10448835983217e-26 MirTarget;miRNATAP -0.419583167151917 1.42259707146721e-08 NA NA NA hsa-miR-10a-5p FLT1 -1.17164272592931 4.86621098042279e-24 1.81517574635769 1.10448835983217e-26 miRNATAP -0.360911769443886 8.55461520244007e-06 NA NA NA hsa-miR-149-5p FLT1 -1.95790336710741 8.46371715052367e-27 1.81517574635769 1.10448835983217e-26 MirTarget -0.399959935574143 3.74282493289576e-16 NA NA NA hsa-miR-200b-3p FLT1 -1.70383252137161 2.38979336321755e-30 1.81517574635769 1.10448835983217e-26 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.400501248620924 3.76845913581599e-11 21115742 Forced miR-200 expression suppressed Flt1 levels in metastasis-prone lung adenocarcinoma cells derived from K-ras/p53-mutant mice and negatively regulated the Flt1 3'-UTR in reporter assays; We conclude that miR-200 suppresses lung tumorigenesis by targeting Flt1 metastasis;tumorigenesis lung cancer hsa-miR-200c-3p FLT1 -5.40303134829523 2.74173143360645e-94 1.81517574635769 1.10448835983217e-26 miRNAWalker2_validate;miRTarBase;MirTarget -0.304428126244817 1.44888713983443e-30 NA NA NA hsa-miR-20b-5p FLT1 -1.30218163823367 6.87172815978149e-17 1.81517574635769 1.10448835983217e-26 MirTarget;miRNATAP -0.393971858847136 7.87802197069509e-11 NA NA NA hsa-miR-22-5p FLT1 -0.197038086012602 0.106234828461117 1.81517574635769 1.10448835983217e-26 MirTarget -0.487561865206754 2.71190099492294e-09 NA NA NA hsa-miR-29a-5p FLT1 -0.519003718107105 1.03351148282116e-06 1.81517574635769 1.10448835983217e-26 MirTarget -0.586299743971952 2.26338228021702e-10 NA NA NA hsa-miR-335-3p FLT1 -1.36498175550207 6.84287752180534e-13 1.81517574635769 1.10448835983217e-26 mirMAP -0.337519735728676 1.81513836278812e-11 NA NA NA hsa-miR-429 FLT1 -2.16569233119434 2.66862243626443e-37 1.81517574635769 1.10448835983217e-26 MirTarget;miRanda;miRNATAP -0.33754297250473 8.14366131336631e-11 NA NA NA hsa-miR-501-5p FLT1 -1.1103073934745 1.81589804886553e-16 1.81517574635769 1.10448835983217e-26 mirMAP -0.483930077905975 4.19503456488762e-12 NA NA NA hsa-miR-664a-5p FLT1 -0.618481839889218 7.01961389909184e-09 1.81517574635769 1.10448835983217e-26 MirTarget -0.421272532785725 5.42268477509845e-06 NA NA NA hsa-miR-874-3p FLT1 -1.50243370621573 8.39418307315909e-25 1.81517574635769 1.10448835983217e-26 MirTarget -0.352663167390114 2.72717237789663e-08 NA NA NA hsa-miR-125a-5p FLT3 -0.561874059994802 7.3931856356891e-13 0.610289767826127 0.0244691370210934 miRanda -0.740480916419243 6.60726191896486e-05 NA NA NA hsa-miR-335-5p FLT3 -2.09515619961552 1.03765771499548e-25 0.610289767826127 0.0244691370210934 miRNAWalker2_validate -0.221140926861003 0.00154374486820464 NA NA NA hsa-miR-199b-5p FLT4 -2.39483476763681 1.04659509514884e-17 1.02779259814417 7.24979598797067e-13 miRanda -0.142746235017119 3.55749364034554e-07 NA NA NA hsa-miR-429 FLT4 -2.16569233119434 2.66862243626443e-37 1.02779259814417 7.24979598797067e-13 miRanda;miRNATAP -0.204415836765987 1.46840427271399e-06 NA NA NA hsa-miR-1271-5p FOXO4 0.900599702972936 3.07963385418853e-10 -0.792791409452617 1.14471623095335e-31 MirTarget -0.102101323543335 0.000248241266739397 NA NA NA hsa-miR-128-3p FOXO4 0.475045893035043 2.6255647468e-06 -0.792791409452617 1.14471623095335e-31 MirTarget -0.124721868465884 0.00195060440665719 NA NA NA hsa-miR-142-3p FOXO4 1.88928758773299 2.72985643829893e-22 -0.792791409452617 1.14471623095335e-31 MirTarget;miRanda;miRNATAP -0.181563037995841 7.31790182112454e-23 NA NA NA hsa-miR-150-5p FOXO4 1.00371863159681 1.09871676395528e-09 -0.792791409452617 1.14471623095335e-31 MirTarget;miRNATAP -0.139556912671815 4.82045545406621e-09 26715362 microRNA 150 promotes cervical cancer cell growth and survival by targeting FOXO4; Taken together our data demonstrated that elevated miR-150 targets FOXO4 expression and therefore regulates multiple genes expression resulting in cervical cancer cell growth and survival poor survival cervical and endocervical cancer hsa-miR-193a-3p FOXO4 0.849206638484406 3.68101781083335e-14 -0.792791409452617 1.14471623095335e-31 miRanda;miRNATAP -0.220587281253438 1.64527368277661e-10 NA NA NA hsa-miR-2355-5p FOXO4 1.57515081110162 3.54962327490702e-48 -0.792791409452617 1.14471623095335e-31 MirTarget -0.2362818822085 8.36194447273769e-14 NA NA NA hsa-miR-23a-3p FOXO4 0.761438723382355 4.09310879199257e-27 -0.792791409452617 1.14471623095335e-31 miRNATAP -0.309092905524692 6.33165082352449e-09 NA NA NA hsa-miR-339-5p FOXO4 0.322848334531193 0.0117281778821612 -0.792791409452617 1.14471623095335e-31 miRanda -0.15891453991311 5.22469756482857e-07 NA NA NA hsa-miR-361-3p FOXO4 1.08992546227594 1.13197240706704e-36 -0.792791409452617 1.14471623095335e-31 mirMAP -0.418434845656698 5.04093796814686e-26 NA NA NA hsa-miR-484 FOXO4 0.571987778099603 9.67278224458421e-10 -0.792791409452617 1.14471623095335e-31 miRNATAP -0.28407620543731 1.21166553601591e-11 NA NA NA hsa-miR-590-5p FOXO4 0.709763558412506 1.11883921359361e-11 -0.792791409452617 1.14471623095335e-31 miRanda -0.257515749436305 3.96494187050619e-12 NA NA NA hsa-let-7a-3p GAB1 0.0677487960013088 0.460458477653989 -0.575093038362963 9.34989196306317e-14 mirMAP -0.168280797621314 0.000518217532219092 NA NA NA hsa-let-7f-1-3p GAB1 0.477913872379336 4.46669616865068e-05 -0.575093038362963 9.34989196306317e-14 mirMAP -0.155690372619064 0.000116038320633833 NA NA NA hsa-miR-106b-5p GAB1 1.07509411417907 2.11739194181878e-36 -0.575093038362963 9.34989196306317e-14 MirTarget;miRNATAP -0.404808584035048 3.15966362443827e-20 NA NA NA hsa-miR-132-3p GAB1 0.291409674711894 0.000912684337101876 -0.575093038362963 9.34989196306317e-14 mirMAP -0.138599449650212 0.00601695354844507 NA NA NA hsa-miR-142-3p GAB1 1.88928758773299 2.72985643829893e-22 -0.575093038362963 9.34989196306317e-14 MirTarget;PITA;miRanda;miRNATAP -0.142668567500804 3.91437478338137e-12 NA NA NA hsa-miR-142-5p GAB1 1.88417391525707 1.2096808039882e-27 -0.575093038362963 9.34989196306317e-14 MirTarget -0.197332226879203 6.67224801492097e-19 NA NA NA hsa-miR-150-5p GAB1 1.00371863159681 1.09871676395528e-09 -0.575093038362963 9.34989196306317e-14 MirTarget -0.114620311721708 9.73451791452124e-06 26871477 MicroRNA 150 suppresses cell proliferation and metastasis in hepatocellular carcinoma by inhibiting the GAB1 ERK axis; Further experiments indicated that Grb2-associated binding protein 1 GAB1 was a direct target of miR-150 in HCC cells; In addition GAB1 expression was increased in HCC tissues and inversely correlated with miR-150 levels; Knockdown of GAB1 mimicked the tumor-suppressive effects of miR-150 overexpression on HCC cells whereas restoration of GAB1 expression partially abolished the inhibitory effects; Moreover miR-150 overexpression decreased GAB1 expression subsequently downregulated phospho-ERK1/2 and suppressed epithelial-mesenchymal-transition EMT; These effects caused by miR-150 overexpression were alleviated by exogenous GAB1 expression metastasis liver cancer hsa-miR-15b-3p GAB1 1.49422666971434 5.44139893275088e-29 -0.575093038362963 9.34989196306317e-14 mirMAP -0.178985831822834 1.55505143255148e-09 NA NA NA hsa-miR-16-1-3p GAB1 1.51429140700091 3.17219833254498e-37 -0.575093038362963 9.34989196306317e-14 mirMAP -0.215167056187932 5.43445986295988e-11 NA NA NA hsa-miR-17-5p GAB1 0.494260110870015 3.8348005261e-09 -0.575093038362963 9.34989196306317e-14 MirTarget;TargetScan;miRNATAP -0.154605332563224 0.00289372006772084 NA NA NA hsa-miR-186-5p GAB1 0.507217561043443 9.04455748270995e-10 -0.575093038362963 9.34989196306317e-14 mirMAP -0.237058528391502 5.1777439817934e-06 NA NA NA hsa-miR-18a-5p GAB1 0.936704393213466 1.05064580570579e-10 -0.575093038362963 9.34989196306317e-14 MirTarget;miRNATAP -0.195331292321861 1.13466839377606e-11 NA NA NA hsa-miR-221-3p GAB1 0.337895669520713 0.0136448974691037 -0.575093038362963 9.34989196306317e-14 MirTarget;miRNATAP -0.217718566998527 3.25500482459672e-12 NA NA NA hsa-miR-222-3p GAB1 0.214811008033524 0.0965295551752457 -0.575093038362963 9.34989196306317e-14 MirTarget;miRNATAP -0.156596780772137 3.91234982510332e-06 NA NA NA hsa-miR-27a-3p GAB1 0.558934437526245 1.44256383086177e-12 -0.575093038362963 9.34989196306317e-14 MirTarget;miRNATAP -0.323602992300535 1.41907609530526e-09 NA NA NA hsa-miR-29a-3p GAB1 -0.431613225927952 4.10166815070288e-08 -0.575093038362963 9.34989196306317e-14 MirTarget;miRNATAP -0.230032867937084 3.18003032436164e-05 NA NA NA hsa-miR-29b-3p GAB1 -0.228125979913806 0.0271621721891603 -0.575093038362963 9.34989196306317e-14 MirTarget -0.20781013069848 9.82173415404343e-07 NA NA NA hsa-miR-330-3p GAB1 0.912906550436308 3.35037014057665e-13 -0.575093038362963 9.34989196306317e-14 PITA;mirMAP;miRNATAP -0.131855140126452 0.000137588009911458 NA NA NA hsa-miR-330-5p GAB1 1.44960468659754 2.12131210588035e-45 -0.575093038362963 9.34989196306317e-14 PITA;miRanda;miRNATAP -0.230733745190441 2.98624335054629e-10 NA NA NA hsa-miR-34a-5p GAB1 1.07544567720768 1.81510842038009e-20 -0.575093038362963 9.34989196306317e-14 MirTarget -0.179614361101842 4.0192060846681e-07 NA NA NA hsa-miR-361-5p GAB1 0.0514169367202078 0.382929376393199 -0.575093038362963 9.34989196306317e-14 mirMAP;miRNATAP -0.224880082134271 0.00350764388980627 NA NA NA hsa-miR-374a-3p GAB1 1.13863935833993 2.79089304015401e-44 -0.575093038362963 9.34989196306317e-14 mirMAP -0.210130563367967 8.1062624740169e-06 NA NA NA hsa-miR-421 GAB1 0.313155739887734 0.020433534776003 -0.575093038362963 9.34989196306317e-14 miRanda -0.158754078622044 2.02086579845842e-06 NA NA NA hsa-miR-590-3p GAB1 1.13702599385212 3.53435739887793e-22 -0.575093038362963 9.34989196306317e-14 miRanda;mirMAP -0.2862457619326 1.82871393599486e-17 NA NA NA hsa-miR-616-5p GAB1 0.913426384742148 3.78418389333709e-09 -0.575093038362963 9.34989196306317e-14 MirTarget;mirMAP -0.173701821382731 3.28022787232036e-10 NA NA NA hsa-miR-93-5p GAB1 1.37365940377595 2.37567548683245e-46 -0.575093038362963 9.34989196306317e-14 MirTarget;miRNATAP -0.19177131167408 1.18268461332094e-06 NA NA NA hsa-let-7d-5p GAB2 -0.0696879530236796 0.333110939877203 0.293256011676148 0.000345692860310907 MirTarget -0.170531601151502 0.00795090197450965 NA NA NA hsa-let-7e-5p GAB2 -0.727009689927955 1.30690859412163e-11 0.293256011676148 0.000345692860310907 MirTarget -0.122961969161896 0.00277900523749239 NA NA NA hsa-miR-200a-3p GAB2 -1.43409013664263 2.00188483717828e-20 0.293256011676148 0.000345692860310907 mirMAP -0.153412804240142 1.48432584628595e-08 NA NA NA hsa-miR-429 GAB2 -2.16569233119434 2.66862243626443e-37 0.293256011676148 0.000345692860310907 miRNATAP -0.11800704087035 5.09353508201677e-07 NA NA NA hsa-miR-664a-5p GAB2 -0.618481839889218 7.01961389909184e-09 0.293256011676148 0.000345692860310907 mirMAP -0.129570413152873 0.00189378366000655 NA NA NA hsa-miR-30b-3p GNB3 -1.64703050862226 1.89878531036464e-31 0.239288600079937 0.309211385629664 MirTarget -0.346008589347179 3.2720172313703e-05 NA NA NA hsa-miR-326 GNB3 0.0283498662828876 0.83943976716391 0.239288600079937 0.309211385629664 miRanda -0.277774570960389 0.00280350951479688 NA NA NA hsa-miR-491-5p GNB3 -0.0898777415179634 0.533906535063567 0.239288600079937 0.309211385629664 miRanda -0.301323222496664 0.00139510124345083 NA NA NA hsa-miR-23b-3p GNB4 -0.533749586990474 2.46924776953771e-10 0.717692744845763 1.31100525221405e-12 mirMAP -0.211940374097266 0.00160357165794238 NA NA NA hsa-miR-27b-3p GNB4 -0.699527231242518 1.07356023759234e-15 0.717692744845763 1.31100525221405e-12 miRNAWalker2_validate -0.427583853172145 4.87387860690263e-12 NA NA NA hsa-miR-29c-3p GNB4 -0.238671318446745 0.0141475322347596 0.717692744845763 1.31100525221405e-12 miRNAWalker2_validate;MirTarget -0.184648551713383 0.00194508201647152 NA NA NA hsa-miR-361-5p GNB4 0.0514169367202078 0.382929376393199 0.717692744845763 1.31100525221405e-12 miRanda;miRNATAP -0.27264099678363 0.00684347057969641 NA NA NA hsa-miR-429 GNB4 -2.16569233119434 2.66862243626443e-37 0.717692744845763 1.31100525221405e-12 miRanda -0.219482046421191 5.39117232314714e-14 NA NA NA hsa-miR-501-5p GNB4 -1.1103073934745 1.81589804886553e-16 0.717692744845763 1.31100525221405e-12 mirMAP -0.190150329553736 2.5700003568722e-06 NA NA NA hsa-miR-130b-3p GNB5 1.12788913578446 2.939369462276e-16 -0.984223544597764 1.38107029018304e-45 miRNAWalker2_validate -0.269344258090407 8.76291599189731e-21 NA NA NA hsa-miR-148a-3p GNB5 0.343233211643815 0.00402279073598165 -0.984223544597764 1.38107029018304e-45 miRNAWalker2_validate -0.120319940242345 0.001103302523172 NA NA NA hsa-miR-17-5p GNB5 0.494260110870015 3.8348005261e-09 -0.984223544597764 1.38107029018304e-45 TargetScan -0.320310422806991 2.46355902549298e-10 NA NA NA hsa-miR-27a-3p GNB5 0.558934437526245 1.44256383086177e-12 -0.984223544597764 1.38107029018304e-45 miRNAWalker2_validate -0.409679443373698 5.39689522339972e-15 NA NA NA hsa-miR-338-3p GNB5 0.906250377628867 2.76970900371139e-15 -0.984223544597764 1.38107029018304e-45 miRanda -0.142339385967291 0.000105957763087804 NA NA NA hsa-miR-342-3p GNB5 1.4124432570595 1.07208971556131e-28 -0.984223544597764 1.38107029018304e-45 miRanda -0.289168057820866 3.15557418760236e-22 NA NA NA hsa-miR-452-3p GNB5 1.72039996672257 1.35748079442153e-22 -0.984223544597764 1.38107029018304e-45 mirMAP -0.195131022442396 9.41598127784812e-18 NA NA NA hsa-miR-590-3p GNB5 1.13702599385212 3.53435739887793e-22 -0.984223544597764 1.38107029018304e-45 miRanda -0.290635863408716 4.52232842245282e-18 NA NA NA hsa-miR-28-5p GNG12 0.461962042257226 3.32424690573327e-11 -0.585710433799246 5.64727247192656e-14 PITA;miRanda -0.213018744184183 0.000716637360164746 NA NA NA hsa-miR-455-5p GNG12 0.773674551205946 2.12957541541474e-09 -0.585710433799246 5.64727247192656e-14 miRanda -0.104628790500717 0.00192421839743675 NA NA NA hsa-miR-590-3p GNG12 1.13702599385212 3.53435739887793e-22 -0.585710433799246 5.64727247192656e-14 miRanda;mirMAP -0.166394460792321 2.45843912730583e-06 NA NA NA hsa-miR-590-5p GNG12 0.709763558412506 1.11883921359361e-11 -0.585710433799246 5.64727247192656e-14 PITA -0.136601828608981 0.000985486999487911 NA NA NA hsa-miR-29a-3p GNG2 -0.431613225927952 4.10166815070288e-08 0.823614756064967 1.80511187005109e-16 miRNATAP -0.35691220884068 7.17320168711146e-07 NA NA NA hsa-miR-29b-3p GNG2 -0.228125979913806 0.0271621721891603 0.823614756064967 1.80511187005109e-16 miRNATAP -0.206480340849552 0.000228846129353865 NA NA NA hsa-miR-29c-3p GNG2 -0.238671318446745 0.0141475322347596 0.823614756064967 1.80511187005109e-16 miRNATAP -0.267920239250733 5.99031053172155e-06 NA NA NA hsa-miR-30a-3p GNG2 -0.955360819934585 1.97009535429185e-20 0.823614756064967 1.80511187005109e-16 mirMAP -0.37288281170127 3.33907900738402e-13 NA NA NA hsa-miR-30a-5p GNG2 -0.778411951775343 2.73322451127932e-16 0.823614756064967 1.80511187005109e-16 miRNAWalker2_validate -0.412510880857411 2.55539102426618e-13 NA NA NA hsa-miR-30d-3p GNG2 -0.249777194282131 0.00235356711813496 0.823614756064967 1.80511187005109e-16 mirMAP -0.470582597511604 8.19002809998308e-12 NA NA NA hsa-miR-30e-3p GNG2 -0.205602546270795 0.00132666419729688 0.823614756064967 1.80511187005109e-16 mirMAP -0.343464152924407 0.00016836421394781 NA NA NA hsa-miR-429 GNG2 -2.16569233119434 2.66862243626443e-37 0.823614756064967 1.80511187005109e-16 miRanda;miRNATAP -0.253789883611854 1.10635594413729e-18 NA NA NA hsa-miR-500a-5p GNG2 -1.28374735824553 1.95870374809798e-20 0.823614756064967 1.80511187005109e-16 mirMAP -0.225936528577725 4.77391846047053e-09 NA NA NA hsa-miR-577 GNG2 -1.48881999472397 7.03080165111147e-10 0.823614756064967 1.80511187005109e-16 PITA;miRNATAP -0.136210305680153 2.89907477737182e-09 NA NA NA hsa-miR-126-5p GNG4 0.785607261431085 5.77058629454465e-13 -1.44375114410306 2.28630638387692e-07 mirMAP -0.597454797087056 1.5130403812957e-05 NA NA NA hsa-miR-23a-3p GNG4 0.761438723382355 4.09310879199257e-27 -1.44375114410306 2.28630638387692e-07 mirMAP -0.914505114643854 8.27962995646909e-06 NA NA NA hsa-miR-338-3p GNG4 0.906250377628867 2.76970900371139e-15 -1.44375114410306 2.28630638387692e-07 miRanda -0.546769890839939 2.68695118081473e-05 NA NA NA hsa-miR-452-5p GNG4 2.05325688842141 2.82238393643084e-40 -1.44375114410306 2.28630638387692e-07 mirMAP -0.331111037226154 0.000199421136759586 NA NA NA hsa-miR-1271-5p GNG7 0.900599702972936 3.07963385418853e-10 -1.49819687293184 1.94705916577757e-31 mirMAP -0.173568129162765 0.00107819615408948 NA NA NA hsa-miR-17-3p GNG7 0.723795600017259 5.90151677164931e-18 -1.49819687293184 1.94705916577757e-31 mirMAP -0.361965077865094 4.41700180577189e-05 NA NA NA hsa-miR-185-3p GNG7 0.993379985307475 2.62011454953707e-13 -1.49819687293184 1.94705916577757e-31 mirMAP -0.229710067712246 3.97501622169706e-05 NA NA NA hsa-miR-18a-5p GNG7 0.936704393213466 1.05064580570579e-10 -1.49819687293184 1.94705916577757e-31 mirMAP -0.348837810365023 6.96927332073749e-12 NA NA NA hsa-miR-193b-5p GNG7 0.277625648727715 0.101981573602756 -1.49819687293184 1.94705916577757e-31 mirMAP -0.179718134208955 0.000110918918737654 NA NA NA hsa-miR-1976 GNG7 0.343475600930938 0.000360243844871748 -1.49819687293184 1.94705916577757e-31 mirMAP -0.370726871325751 3.93316058485566e-06 NA NA NA hsa-miR-22-3p GNG7 0.198460552200729 0.00761005672059428 -1.49819687293184 1.94705916577757e-31 mirMAP -0.301197282065867 0.00460653426986487 NA NA NA hsa-miR-224-5p GNG7 2.84654230414912 3.0480927226395e-47 -1.49819687293184 1.94705916577757e-31 mirMAP -0.308453023695823 5.82969137794952e-22 NA NA NA hsa-miR-23a-3p GNG7 0.761438723382355 4.09310879199257e-27 -1.49819687293184 1.94705916577757e-31 mirMAP -0.698775615633595 2.84763217380429e-12 NA NA NA hsa-miR-3127-5p GNG7 0.952801473575318 5.81162987769266e-14 -1.49819687293184 1.94705916577757e-31 mirMAP -0.330875336506744 5.09478016318189e-08 NA NA NA hsa-miR-330-5p GNG7 1.44960468659754 2.12131210588035e-45 -1.49819687293184 1.94705916577757e-31 mirMAP -0.678483798096591 7.25501185995044e-29 NA NA NA hsa-miR-378a-3p GNG7 0.287244802401236 0.0501155019984562 -1.49819687293184 1.94705916577757e-31 mirMAP -0.138764304559557 0.0093327947717712 NA NA NA hsa-miR-378c GNG7 0.755048315231594 3.56147090439556e-06 -1.49819687293184 1.94705916577757e-31 mirMAP -0.227076752133234 1.50215467209031e-06 NA NA NA hsa-miR-590-3p GNG7 1.13702599385212 3.53435739887793e-22 -1.49819687293184 1.94705916577757e-31 PITA;miRanda;mirMAP -0.564634408721835 6.1436653475734e-22 NA NA NA hsa-miR-616-5p GNG7 0.913426384742148 3.78418389333709e-09 -1.49819687293184 1.94705916577757e-31 MirTarget -0.342251160982075 1.72542542503839e-12 NA NA NA hsa-miR-671-5p GNG7 0.740296481994777 8.07053661008188e-07 -1.49819687293184 1.94705916577757e-31 mirMAP -0.303845706127119 2.21754508249776e-09 NA NA NA hsa-miR-92a-3p GNG7 0.178194888895831 0.0088835082650834 -1.49819687293184 1.94705916577757e-31 miRNAWalker2_validate -0.379497275513069 0.00109890059281857 NA NA NA hsa-miR-335-5p GNGT1 -2.09515619961552 1.03765771499548e-25 2.03953706077506 5.8671355429219e-10 miRNAWalker2_validate -0.340008772213866 8.62143560659247e-05 NA NA NA hsa-miR-30c-2-3p GNGT2 -1.28402709024345 6.77577627955178e-25 0.777628423465873 2.67156169725857e-15 MirTarget -0.268089918566553 7.06377033325458e-11 NA NA NA hsa-miR-200b-3p GRIN2A -1.70383252137161 2.38979336321755e-30 0.49450578116535 0.105514934496887 TargetScan -0.36319237328719 0.000407959636252492 NA NA NA hsa-miR-362-3p GRIN2A -0.753214251798232 3.0025661608035e-07 0.49450578116535 0.105514934496887 miRanda -0.41352088227644 0.000361490233382556 NA NA NA hsa-miR-30e-5p HGF -0.0905907245198101 0.21196704484334 -0.738793589777388 4.41427313714235e-05 mirMAP -0.379549873001778 0.00724387151296551 NA NA NA hsa-miR-616-5p HGF 0.913426384742148 3.78418389333709e-09 -0.738793589777388 4.41427313714235e-05 mirMAP -0.206992633336022 0.00132857792892172 NA NA NA hsa-miR-651-5p HGF 0.535144061895781 2.49922577209869e-05 -0.738793589777388 4.41427313714235e-05 MirTarget -0.333113418919824 6.12549830512164e-05 NA NA NA hsa-miR-125a-5p HTR7 -0.561874059994802 7.3931856356891e-13 1.83080538045378 8.23588375719935e-23 miRanda -0.793833316734682 3.52447563526447e-09 NA NA NA hsa-miR-335-5p HTR7 -2.09515619961552 1.03765771499548e-25 1.83080538045378 8.23588375719935e-23 miRNAWalker2_validate -0.229405227614216 6.64526529878098e-06 NA NA NA hsa-miR-375 HTR7 -1.46468479447701 9.20596529469647e-07 1.83080538045378 8.23588375719935e-23 miRanda -0.10718000985451 0.00309506978636538 NA NA NA hsa-let-7i-5p IGF1R 0.911372377723717 7.11483853341932e-31 -0.350712337754094 0.000181501245112752 MirTarget;miRNATAP -0.235971113803716 8.77155505277996e-05 NA NA NA hsa-miR-140-5p IGF1R 0.504309496243674 3.09884038729031e-11 -0.350712337754094 0.000181501245112752 PITA;miRNATAP -0.181571155101918 0.00699418491290811 24039995 Integrated analysis identified IGF1R as a direct and functional target of miR-140; Knockdown of IGF1R inhibited cell proliferation and invasion resembling that of miR-140 overexpression while overexpression of IGF1R attenuated the function of miR-140 in NSCLC cells; Together our results highlight the significance of miR-140 and IGF1R in the development and progression of NSCLC progression lung squamous cell cancer hsa-miR-146b-5p IGF1R 1.40714170253819 2.9559871816487e-12 -0.350712337754094 0.000181501245112752 miRanda -0.152403247660519 3.66075996358974e-10 NA NA NA hsa-miR-148a-5p IGF1R 0.415500302855613 0.000691460831436767 -0.350712337754094 0.000181501245112752 mirMAP -0.170503521690951 5.04273345128948e-05 NA NA NA hsa-miR-150-5p IGF1R 1.00371863159681 1.09871676395528e-09 -0.350712337754094 0.000181501245112752 mirMAP -0.143553806575444 2.42346952261794e-06 NA NA NA hsa-miR-152-3p IGF1R 0.187079360533734 0.052276214844753 -0.350712337754094 0.000181501245112752 miRNAWalker2_validate;miRTarBase -0.190544615783346 0.000432891552015195 NA NA NA hsa-miR-155-5p IGF1R 3.26274490570809 5.06841441826518e-51 -0.350712337754094 0.000181501245112752 mirMAP -0.136590052634235 4.91008523423482e-12 NA NA NA hsa-miR-15a-5p IGF1R 1.42663930007845 1.36006952074963e-57 -0.350712337754094 0.000181501245112752 miRNATAP -0.229960567738301 2.06108623158748e-06 NA NA NA hsa-miR-15b-3p IGF1R 1.49422666971434 5.44139893275088e-29 -0.350712337754094 0.000181501245112752 mirMAP -0.134683049212029 0.000147723404766299 NA NA NA hsa-miR-15b-5p IGF1R 0.773001494057531 1.71784656078957e-16 -0.350712337754094 0.000181501245112752 miRNATAP -0.304632210575091 5.12529969919797e-09 NA NA NA hsa-miR-16-1-3p IGF1R 1.51429140700091 3.17219833254498e-37 -0.350712337754094 0.000181501245112752 mirMAP -0.123058260397 0.00189781201814508 NA NA NA hsa-miR-16-5p IGF1R 0.934012514027655 4.85417898318515e-24 -0.350712337754094 0.000181501245112752 miRNATAP -0.222754861619978 2.02733002979059e-05 23507142 Furthermore we confirmed that IGF1R is a direct target of miR-16; In clinical specimens IGF1R levels inversely correlate with miR-16 expression; Our results provide significant clues regarding the role of miR-16 as a tumor suppressor by targeting IGF1R in OS sarcoma hsa-miR-181b-5p IGF1R 1.49054296272357 3.69051660739368e-41 -0.350712337754094 0.000181501245112752 miRNAWalker2_validate -0.16087164704991 9.10123692332483e-05 NA NA NA hsa-miR-185-5p IGF1R 1.05056378692621 1.31174187880682e-22 -0.350712337754094 0.000181501245112752 MirTarget -0.186053432064591 3.69788233879511e-05 NA NA NA hsa-miR-186-5p IGF1R 0.507217561043443 9.04455748270995e-10 -0.350712337754094 0.000181501245112752 mirMAP -0.331419313505495 5.07936007018379e-08 NA NA NA hsa-miR-193a-5p IGF1R 1.29777740059595 2.16815694068336e-39 -0.350712337754094 0.000181501245112752 mirMAP -0.282185055621775 6.5125643029761e-10 NA NA NA hsa-miR-19a-3p IGF1R 0.722913586880779 2.76301458932381e-10 -0.350712337754094 0.000181501245112752 mirMAP -0.147886658493526 0.000827009672119645 NA NA NA hsa-miR-22-5p IGF1R -0.197038086012602 0.106234828461117 -0.350712337754094 0.000181501245112752 miRNATAP -0.218185482688399 2.31606589217884e-07 NA NA NA hsa-miR-223-3p IGF1R 1.23291409735619 1.07767240442694e-17 -0.350712337754094 0.000181501245112752 miRNAWalker2_validate;miRTarBase;MirTarget -0.207002717101274 6.7497817419045e-10 NA NA NA hsa-miR-224-5p IGF1R 2.84654230414912 3.0480927226395e-47 -0.350712337754094 0.000181501245112752 mirMAP -0.12497449009427 2.14169011755518e-08 NA NA NA hsa-miR-27a-3p IGF1R 0.558934437526245 1.44256383086177e-12 -0.350712337754094 0.000181501245112752 mirMAP -0.289086082917443 5.70429020582017e-06 NA NA NA hsa-miR-28-3p IGF1R 1.01277915413238 1.8655970171461e-43 -0.350712337754094 0.000181501245112752 miRNATAP -0.283676409136567 4.77334416869934e-06 NA NA NA hsa-miR-29b-3p IGF1R -0.228125979913806 0.0271621721891603 -0.350712337754094 0.000181501245112752 mirMAP -0.180564508317091 0.000341128991851936 NA NA NA hsa-miR-320b IGF1R 0.300497419754843 0.0245219177384172 -0.350712337754094 0.000181501245112752 PITA;mirMAP;miRNATAP -0.147694319321643 0.000138439977633767 NA NA NA hsa-miR-330-3p IGF1R 0.912906550436308 3.35037014057665e-13 -0.350712337754094 0.000181501245112752 MirTarget;PITA;miRNATAP -0.134477746862817 0.000990824178827728 NA NA NA hsa-miR-331-5p IGF1R 0.661186030542026 1.83628790002785e-08 -0.350712337754094 0.000181501245112752 PITA -0.195351804223524 1.40133581842936e-05 NA NA NA hsa-miR-339-5p IGF1R 0.322848334531193 0.0117281778821612 -0.350712337754094 0.000181501245112752 miRanda -0.163351873718725 5.15049729928241e-05 NA NA NA hsa-miR-342-3p IGF1R 1.4124432570595 1.07208971556131e-28 -0.350712337754094 0.000181501245112752 mirMAP -0.194272553620367 1.46833451467849e-07 NA NA NA hsa-miR-342-5p IGF1R 1.37011183051517 4.99462376051624e-28 -0.350712337754094 0.000181501245112752 mirMAP -0.20160351781794 8.83447249312956e-08 NA NA NA hsa-miR-34a-5p IGF1R 1.07544567720768 1.81510842038009e-20 -0.350712337754094 0.000181501245112752 miRNAWalker2_validate -0.199114338235112 1.92827507575165e-06 NA NA NA hsa-miR-3613-5p IGF1R 1.6648190889407 3.78720979041391e-41 -0.350712337754094 0.000181501245112752 mirMAP;miRNATAP -0.216252562136664 2.97012797504412e-09 NA NA NA hsa-miR-365a-3p IGF1R 0.80809616164259 2.36039522526e-12 -0.350712337754094 0.000181501245112752 MirTarget -0.257585442885011 1.78868807843146e-09 NA NA NA hsa-miR-3677-3p IGF1R 0.795647411414935 8.55447772820001e-08 -0.350712337754094 0.000181501245112752 MirTarget -0.148125144581854 1.72647727870061e-05 NA NA NA hsa-miR-452-5p IGF1R 2.05325688842141 2.82238393643084e-40 -0.350712337754094 0.000181501245112752 mirMAP -0.152551163662331 1.80294964421603e-07 NA NA NA hsa-miR-484 IGF1R 0.571987778099603 9.67278224458421e-10 -0.350712337754094 0.000181501245112752 miRNAWalker2_validate -0.287005519658643 9.24245685466692e-08 NA NA NA hsa-miR-625-5p IGF1R 0.153090549230629 0.330314026509869 -0.350712337754094 0.000181501245112752 MirTarget -0.174794954597001 8.31464126079677e-07 NA NA NA hsa-miR-671-5p IGF1R 0.740296481994777 8.07053661008188e-07 -0.350712337754094 0.000181501245112752 mirMAP -0.192811849893229 1.28982078484569e-08 NA NA NA hsa-miR-1270 IGF2 1.71697026896618 1.75919401373445e-16 -2.34687860267691 1.42284788106786e-12 mirMAP -0.73515689729303 3.91146297613841e-19 NA NA NA hsa-miR-130b-3p IGF2 1.12788913578446 2.939369462276e-16 -2.34687860267691 1.42284788106786e-12 mirMAP -0.383536395412308 0.00349967963548454 NA NA NA hsa-miR-148a-3p IGF2 0.343233211643815 0.00402279073598165 -2.34687860267691 1.42284788106786e-12 mirMAP -0.654138259141622 3.32865042161338e-05 NA NA NA hsa-miR-148b-3p IGF2 0.346011252093377 4.27203463315056e-06 -2.34687860267691 1.42284788106786e-12 mirMAP -1.71895491015101 1.85621380140659e-12 NA NA NA hsa-miR-150-5p IGF2 1.00371863159681 1.09871676395528e-09 -2.34687860267691 1.42284788106786e-12 miRNAWalker2_validate -0.504624603673111 5.55334474383065e-06 NA NA NA hsa-miR-192-3p IGF2 0.156650099616707 0.483496040900362 -2.34687860267691 1.42284788106786e-12 miRNATAP -0.496197183736798 2.88450959711526e-09 NA NA NA hsa-miR-192-5p IGF2 0.442478872410106 0.0669238175123954 -2.34687860267691 1.42284788106786e-12 mirMAP -0.705443978199752 8.38434404741778e-22 NA NA NA hsa-miR-193a-5p IGF2 1.29777740059595 2.16815694068336e-39 -2.34687860267691 1.42284788106786e-12 TargetScan -0.725320261377095 1.76455770060032e-05 NA NA NA hsa-miR-193b-5p IGF2 0.277625648727715 0.101981573602756 -2.34687860267691 1.42284788106786e-12 mirMAP -0.406407934916035 0.000319819516609851 NA NA NA hsa-miR-19a-3p IGF2 0.722913586880779 2.76301458932381e-10 -2.34687860267691 1.42284788106786e-12 mirMAP -0.483354371261257 0.00275245752352663 NA NA NA hsa-miR-210-3p IGF2 3.47797426172621 4.63893951975373e-58 -2.34687860267691 1.42284788106786e-12 MirTarget -0.399171749413733 2.48383490756897e-08 NA NA NA hsa-miR-2355-5p IGF2 1.57515081110162 3.54962327490702e-48 -2.34687860267691 1.42284788106786e-12 MirTarget -0.759977156661094 3.56542845876582e-07 NA NA NA hsa-miR-342-5p IGF2 1.37011183051517 4.99462376051624e-28 -2.34687860267691 1.42284788106786e-12 MirTarget;mirMAP;miRNATAP -0.778822292861011 1.28924754059121e-08 NA NA NA hsa-miR-34a-5p IGF2 1.07544567720768 1.81510842038009e-20 -2.34687860267691 1.42284788106786e-12 mirMAP -0.58108770683083 0.000151312903300126 NA NA NA hsa-miR-361-3p IGF2 1.08992546227594 1.13197240706704e-36 -2.34687860267691 1.42284788106786e-12 mirMAP -1.24161356747156 1.14100755076694e-10 NA NA NA hsa-miR-365a-3p IGF2 0.80809616164259 2.36039522526e-12 -2.34687860267691 1.42284788106786e-12 MirTarget -0.502435693396011 0.00159623003066334 NA NA NA hsa-miR-454-3p IGF2 0.68285296887698 1.17407812677787e-08 -2.34687860267691 1.42284788106786e-12 mirMAP -0.811242152746126 1.13111009951846e-07 NA NA NA hsa-miR-455-5p IGF2 0.773674551205946 2.12957541541474e-09 -2.34687860267691 1.42284788106786e-12 mirMAP -0.633432384566236 8.30880921791159e-06 NA NA NA hsa-miR-484 IGF2 0.571987778099603 9.67278224458421e-10 -2.34687860267691 1.42284788106786e-12 miRNATAP -0.808384230578006 4.28299864386457e-05 NA NA NA hsa-miR-93-5p IGF2 1.37365940377595 2.37567548683245e-46 -2.34687860267691 1.42284788106786e-12 miRNAWalker2_validate -1.04972427218725 3.52183702203594e-10 NA NA NA hsa-miR-125a-5p IKBKG -0.561874059994802 7.3931856356891e-13 0.49642799282577 6.30392568162462e-12 miRanda -0.278136800860417 3.13020186123498e-08 NA NA NA hsa-let-7g-5p INSR -0.739744008507763 1.07979566264383e-14 1.22098476669768 3.16404602120675e-24 miRNATAP -0.395547105658983 2.23686684327675e-08 NA NA NA hsa-miR-127-5p INSR -1.33574359249785 5.73079880594981e-13 1.22098476669768 3.16404602120675e-24 PITA -0.127873340011271 0.00054969179221113 NA NA NA hsa-miR-141-3p INSR -5.87110686537457 1.20877726722907e-85 1.22098476669768 3.16404602120675e-24 mirMAP -0.193501789971366 6.25874754232476e-31 27186273 microRNA 141 inhibits thyroid cancer cell growth and metastasis by targeting insulin receptor substrate 2 metastasis thyroid cancer hsa-miR-200a-3p INSR -1.43409013664263 2.00188483717828e-20 1.22098476669768 3.16404602120675e-24 mirMAP -0.220629068778301 2.49414920313771e-07 NA NA NA hsa-miR-335-3p INSR -1.36498175550207 6.84287752180534e-13 1.22098476669768 3.16404602120675e-24 mirMAP -0.269288069300444 1.16034201980538e-14 23966614 miR 335 inhibits small cell lung cancer bone metastases via IGF IR and RANKL pathways metastasis lung squamous cell cancer hsa-miR-429 INSR -2.16569233119434 2.66862243626443e-37 1.22098476669768 3.16404602120675e-24 miRNATAP -0.233302577772816 1.65426561724317e-10 NA NA NA hsa-miR-495-3p INSR -0.742293735164333 7.11373308013543e-05 1.22098476669768 3.16404602120675e-24 mirMAP -0.157976472369521 4.66370468956541e-05 NA NA NA hsa-miR-501-5p INSR -1.1103073934745 1.81589804886553e-16 1.22098476669768 3.16404602120675e-24 miRNATAP -0.321346382831813 6.65387363749468e-11 NA NA NA hsa-miR-539-5p INSR -1.44841597031461 8.25650852878567e-11 1.22098476669768 3.16404602120675e-24 mirMAP -0.142403631765939 6.87039219743717e-06 NA NA NA hsa-miR-940 JMJD7-PLA2G4B -0.160421460715008 0.279016637176929 0.151094662027853 0.188937979716058 miRNATAP -0.163357602541697 0.000249936751053691 NA NA NA hsa-miR-149-5p KDR -1.95790336710741 8.46371715052367e-27 0.985118895051475 1.02914063123208e-08 miRNATAP -0.285208531235896 2.71184164647722e-09 NA NA NA hsa-miR-200b-3p KDR -1.70383252137161 2.38979336321755e-30 0.985118895051475 1.02914063123208e-08 miRNAWalker2_validate;miRTarBase;TargetScan -0.27162342475752 3.81432938994288e-06 NA NA NA hsa-miR-200c-3p KDR -5.40303134829523 2.74173143360645e-94 0.985118895051475 1.02914063123208e-08 miRNATAP -0.193548659793197 5.20778982168023e-13 24205206 MiR 200c increases the radiosensitivity of non small cell lung cancer cell line A549 by targeting VEGF VEGFR2 pathway; MiR-200c at the nexus of epithelial-mesenchymal transition EMT is predicted to target VEGFR2; The purpose of this study is to test the hypothesis that regulation of VEGFR2 pathway by miR-200c could modulate the radiosensitivity of cancer cells; Bioinformatic analysis luciferase reporter assays and biochemical assays were carried out to validate VEGFR2 as a direct target of miR-200c; We identified VEGFR2 as a novel target of miR-200c lung squamous cell cancer hsa-miR-335-5p KDR -2.09515619961552 1.03765771499548e-25 0.985118895051475 1.02914063123208e-08 miRNAWalker2_validate -0.236883657749445 1.08371410170902e-07 NA NA NA hsa-miR-429 KDR -2.16569233119434 2.66862243626443e-37 0.985118895051475 1.02914063123208e-08 PITA;miRanda;miRNATAP -0.202657874192441 6.11847457705003e-05 NA NA NA hsa-let-7f-1-3p KIT 0.477913872379336 4.46669616865068e-05 -2.21992984400247 1.58406195649638e-30 mirMAP -0.378337992988295 0.000431573662242811 NA NA NA hsa-miR-128-3p KIT 0.475045893035043 2.6255647468e-06 -2.21992984400247 1.58406195649638e-30 MirTarget -0.626155450841991 3.08580485383805e-08 NA NA NA hsa-miR-130b-3p KIT 1.12788913578446 2.939369462276e-16 -2.21992984400247 1.58406195649638e-30 miRNATAP -0.67929887508987 1.35655636281634e-18 NA NA NA hsa-miR-142-5p KIT 1.88417391525707 1.2096808039882e-27 -2.21992984400247 1.58406195649638e-30 PITA;miRNATAP -0.540689315093856 3.54841122745544e-20 NA NA NA hsa-miR-146b-5p KIT 1.40714170253819 2.9559871816487e-12 -2.21992984400247 1.58406195649638e-30 miRNAWalker2_validate -0.4457774999771 9.44953820156257e-17 NA NA NA hsa-miR-186-5p KIT 0.507217561043443 9.04455748270995e-10 -2.21992984400247 1.58406195649638e-30 miRNAWalker2_validate -0.868269314889548 1.7564876750562e-10 NA NA NA hsa-miR-193a-3p KIT 0.849206638484406 3.68101781083335e-14 -2.21992984400247 1.58406195649638e-30 MirTarget;PITA;miRanda;miRNATAP -0.672624908086957 6.91906460037293e-12 NA NA NA hsa-miR-195-3p KIT 0.808592887366705 6.8151241038711e-09 -2.21992984400247 1.58406195649638e-30 miRNATAP -0.279937786770183 0.00071287632494586 NA NA NA hsa-miR-19a-3p KIT 0.722913586880779 2.76301458932381e-10 -2.21992984400247 1.58406195649638e-30 miRTarBase;miRNATAP -0.602700425289326 7.00869649151469e-10 NA NA NA hsa-miR-19b-3p KIT 0.195940928879427 0.0300512922542325 -2.21992984400247 1.58406195649638e-30 miRNATAP -0.476954724802295 0.000253004442771608 NA NA NA hsa-miR-20a-5p KIT 0.702602695798242 4.06372887613329e-13 -2.21992984400247 1.58406195649638e-30 miRTarBase -0.604373490728516 1.77119512817736e-07 NA NA NA hsa-miR-301a-3p KIT 0.259400847075798 0.0216890736701418 -2.21992984400247 1.58406195649638e-30 miRNATAP -0.561470220020192 4.14396084155108e-08 NA NA NA hsa-miR-338-3p KIT 0.906250377628867 2.76970900371139e-15 -2.21992984400247 1.58406195649638e-30 miRanda -0.325225663119539 0.000900259125510807 NA NA NA hsa-miR-342-3p KIT 1.4124432570595 1.07208971556131e-28 -2.21992984400247 1.58406195649638e-30 miRanda -0.769676396309162 2.90516819271403e-22 NA NA NA hsa-miR-34a-5p KIT 1.07544567720768 1.81510842038009e-20 -2.21992984400247 1.58406195649638e-30 MirTarget -0.713227505166628 7.27672715727417e-15 NA NA NA hsa-miR-421 KIT 0.313155739887734 0.020433534776003 -2.21992984400247 1.58406195649638e-30 miRanda -0.352939367438444 7.61398922778979e-05 NA NA NA hsa-miR-450b-5p KIT 0.404819502355575 0.00357671373841274 -2.21992984400247 1.58406195649638e-30 MirTarget -0.254346785524299 0.00250879082300239 NA NA NA hsa-miR-454-3p KIT 0.68285296887698 1.17407812677787e-08 -2.21992984400247 1.58406195649638e-30 miRNATAP -0.69150058557585 8.86986795393098e-14 NA NA NA hsa-miR-505-3p KIT -0.0591326765593969 0.556908871953633 -2.21992984400247 1.58406195649638e-30 MirTarget;miRNATAP -0.311107178796799 0.00818234538972183 NA NA NA hsa-miR-590-3p KIT 1.13702599385212 3.53435739887793e-22 -2.21992984400247 1.58406195649638e-30 miRanda;mirMAP -0.690614524740843 2.07558876015919e-14 NA NA NA hsa-miR-671-5p KIT 0.740296481994777 8.07053661008188e-07 -2.21992984400247 1.58406195649638e-30 MirTarget -0.325854888238492 2.5099309324694e-05 NA NA NA hsa-miR-1270 KITLG 1.71697026896618 1.75919401373445e-16 -1.86297449161736 3.98973030513653e-32 MirTarget;PITA -0.256523375868721 2.93369022853655e-09 NA NA NA hsa-miR-142-5p KITLG 1.88417391525707 1.2096808039882e-27 -1.86297449161736 3.98973030513653e-32 MirTarget;PITA -0.433836055341139 3.12640800994414e-19 NA NA NA hsa-miR-144-3p KITLG 1.4617706700291 9.18139413836375e-11 -1.86297449161736 3.98973030513653e-32 MirTarget -0.17632163671727 1.82879393114234e-05 NA NA NA hsa-miR-17-3p KITLG 0.723795600017259 5.90151677164931e-18 -1.86297449161736 3.98973030513653e-32 MirTarget -0.587849267098174 5.4837481938984e-08 NA NA NA hsa-miR-181a-5p KITLG 1.11111114875339 3.97880443756442e-29 -1.86297449161736 3.98973030513653e-32 MirTarget -0.398430294974858 6.49026906724375e-06 NA NA NA hsa-miR-181b-5p KITLG 1.49054296272357 3.69051660739368e-41 -1.86297449161736 3.98973030513653e-32 MirTarget -0.447122201638632 2.44640753459748e-09 NA NA NA hsa-miR-185-5p KITLG 1.05056378692621 1.31174187880682e-22 -1.86297449161736 3.98973030513653e-32 miRNAWalker2_validate -0.524717768158724 1.5686558262394e-10 NA NA NA hsa-miR-186-5p KITLG 0.507217561043443 9.04455748270995e-10 -1.86297449161736 3.98973030513653e-32 mirMAP -0.602936844388262 8.88156820272543e-08 NA NA NA hsa-miR-192-3p KITLG 0.156650099616707 0.483496040900362 -1.86297449161736 3.98973030513653e-32 mirMAP -0.170795026079867 7.43022213984735e-05 NA NA NA hsa-miR-19a-3p KITLG 0.722913586880779 2.76301458932381e-10 -1.86297449161736 3.98973030513653e-32 mirMAP -0.437730576327869 5.98884192970255e-08 NA NA NA hsa-miR-19b-3p KITLG 0.195940928879427 0.0300512922542325 -1.86297449161736 3.98973030513653e-32 mirMAP -0.374083488237465 0.000478141871982586 NA NA NA hsa-miR-22-5p KITLG -0.197038086012602 0.106234828461117 -1.86297449161736 3.98973030513653e-32 MirTarget -0.287665820873746 0.000267866869699266 NA NA NA hsa-miR-23a-3p KITLG 0.761438723382355 4.09310879199257e-27 -1.86297449161736 3.98973030513653e-32 mirMAP -0.786272343851677 2.37257817570825e-10 NA NA NA hsa-miR-28-3p KITLG 1.01277915413238 1.8655970171461e-43 -1.86297449161736 3.98973030513653e-32 mirMAP -1.01158017808329 2.30714084424531e-20 NA NA NA hsa-miR-320a KITLG 0.412740558379182 2.02929519701706e-05 -1.86297449161736 3.98973030513653e-32 MirTarget;PITA;miRanda -0.293228822980955 0.00304289482425239 NA NA NA hsa-miR-320b KITLG 0.300497419754843 0.0245219177384172 -1.86297449161736 3.98973030513653e-32 MirTarget;PITA;miRanda -0.218416855646807 0.00243832580112543 NA NA NA hsa-miR-330-3p KITLG 0.912906550436308 3.35037014057665e-13 -1.86297449161736 3.98973030513653e-32 MirTarget -0.253883065531183 0.000783948955343714 NA NA NA hsa-miR-34a-5p KITLG 1.07544567720768 1.81510842038009e-20 -1.86297449161736 3.98973030513653e-32 MirTarget -0.500881702059111 5.08151200066889e-11 NA NA NA hsa-miR-374a-5p KITLG 0.543061152108237 2.19403097299769e-14 -1.86297449161736 3.98973030513653e-32 mirMAP -0.647162783955817 6.74981228595456e-07 NA NA NA hsa-miR-374b-5p KITLG 0.0804104684417872 0.365593963035077 -1.86297449161736 3.98973030513653e-32 mirMAP -0.312753277150362 0.00430864198858304 NA NA NA hsa-miR-452-3p KITLG 1.72039996672257 1.35748079442153e-22 -1.86297449161736 3.98973030513653e-32 mirMAP -0.279633052201587 5.07714226373034e-08 NA NA NA hsa-miR-590-3p KITLG 1.13702599385212 3.53435739887793e-22 -1.86297449161736 3.98973030513653e-32 MirTarget;PITA;miRanda -0.612277214280404 8.49694871328764e-17 NA NA NA hsa-miR-7-1-3p KITLG 0.544601828025304 5.33830451326047e-07 -1.86297449161736 3.98973030513653e-32 mirMAP -0.380080722704913 1.21476017966841e-05 NA NA NA hsa-let-7a-3p KRAS 0.0677487960013088 0.460458477653989 -0.255817061539648 9.1459633191595e-05 mirMAP;miRNATAP -0.135776810220158 0.000642882403233645 24727325;20603437;24890702;23324806;21994416;23167843;27620744;20177422;25183481;22584434;18922928 Association study of the let 7 miRNA complementary site variant in the 3' untranslated region of the KRAS gene in stage III colon cancer NCCTG N0147 Clinical Trial; A let-7 microRNA-complementary site LCS6 polymorphism in the 3' untranslated region of the KRAS gene has been shown to disrupt let-7 binding and upregulate KRAS expression;A let 7 microRNA binding site polymorphism in 3' untranslated region of KRAS gene predicts response in wild type KRAS patients with metastatic colorectal cancer treated with cetuximab monotherapy; A polymorphism in a let-7 microRNA complementary site lcs6 in the KRAS 3' untranslated region UTR is associated with an increased cancer risk in non-small-cell lung cancer and reduced overall survival OS in oral cancers; the presence of KRAS let-7 lcs6 polymorphism was evaluated in 130 mCRC patients who were enrolled in a phase II study of cetuximab monotherapy IMCL-0144; KRAS let-7 lcs6 polymorphism was found to be related to object response rate ORR in mCRC patients whose tumors had KRASwt;Let 7 microRNA binding site polymorphism in the 3'UTR of KRAS and colorectal cancer outcome: a systematic review and meta analysis; There is a small but growing body of literature regarding the predictive utility of a Let-7 microRNA-binding-site polymorphism in the 3'-untranslated region UTR of KRAS KRAS-LCS6 for colorectal cancer outcome although the results are conflicting; A PubMed search was conducted to identify all studies reporting on KRAS let-7 microRNA-binding site polymorphism LCS6; rs61764370 and colorectal cancer outcome;The LCS6 polymorphism in the binding site of let 7 microRNA to the KRAS 3' untranslated region: its role in the efficacy of anti EGFR based therapy in metastatic colorectal cancer patients; The lethal-7 let-7 family of microRNAs regulates KRAS activity; We studied the association of the KRAS let-7 LCS6 polymorphism with the response in 100 refractory mCRC patients treated with anti-EGFR antibodies; The KRAS let-7 LCS6 polymorphism was genotyped using the BioMark system in blood and tumor DNA samples; The KRAS let-7 LCS6 G-allele showed a statistically significant association with nonresponse to anti-EGFR-based treatment: 31.9% of patients with the T/T genotype presented a complete or a partial response versus no patients with T/G or G/G genotypes P=0.004;A let 7 microRNA SNP in the KRAS 3'UTR is prognostic in early stage colorectal cancer; Recently a SNP in a lethal-7 let-7 miRNA complementary site LCS6 in the KRAS 3'untranslated region was suggested to affect survival in metastatic CRC;Let 7 miRNA binding site polymorphism in the KRAS 3'UTR; colorectal cancer screening population prevalence and influence on clinical outcome in patients with metastatic colorectal cancer treated with 5 fluorouracil and oxaliplatin +/ cetuximab; Recent studies have reported associations between a variant allele in a let-7 microRNA complementary site LCS6 within the 3'untranslated region 3'UTR of KRAS rs61764370 and clinical outcome in metastatic colorectal cancer mCRC patients receiving cetuximab;A let 7 microRNA binding site polymorphism in the KRAS 3'UTR is associated with increased risk and reduced survival for gallbladder cancer in North Indian population; The let-7 microRNAs play a key role in regulating KRAS expression and a polymorphism in 3' untranslated region rs61764370 T/G of KRAS leads to its higher expression;Genetic modulation of the Let 7 microRNA binding to KRAS 3' untranslated region and survival of metastatic colorectal cancer patients treated with salvage cetuximab irinotecan; There is increasing evidence that the Let-7 microRNA miRNA exerts an effect as a tumor suppressor by targeting the KRAS mRNA; The Let-7 complementary site LCS6 T>G variant in the KRAS 3'-untranslated region weakens Let-7 binding;A let 7 microRNA binding site polymorphism in KRAS predicts improved outcome in patients with metastatic colorectal cancer treated with salvage cetuximab/panitumumab monotherapy;High let 7a microRNA levels in KRAS mutated colorectal carcinomas may rescue anti EGFR therapy effects in patients with chemotherapy refractory metastatic disease; Preclinical and experimental data in vivo indicate that Lethal-7 Let-7 microRNA downregulates KRAS with antitumor effects in the presence of activating KRAS mutations; In 59 patients harboring KRAS mutations Let-7a levels were analyzed for association with overall survival OS and progression-free survival PFS times; An exploratory subgroup analysis was performed using the rs61764370 LCS6 T>G polymorphism that experimentally impairs Let-7 binding to KRAS mRNA; In patients with KRAS mutations Let-7a analysis may serve to identify subgroups of patients who may still benefit from EGFR inhibition and this may open up new perspectives for alternative treatment strategies;A SNP in a let 7 microRNA complementary site in the KRAS 3' untranslated region increases non small cell lung cancer risk; The purpose of this study was to identify single nucleotide polymorphisms SNP that could modify let-7 binding and to assess the effect of such SNPs on target gene regulation and risk for non-small cell lung cancer NSCLC let-7 complementary sites LCS were sequenced in the KRAS 3' untranslated region from 74 NSCLC cases to identify mutations and SNPs that correlated with NSCLC; The LCS6 variant allele in a KRAS miRANA complementary site is significantly associated with increased risk for NSCLC among moderate smokers and represents a new paradigm for let-7 miRNAs in lung cancer susceptibility staging;drug resistance;poor survival;;drug resistance;staging;poor survival;;poor survival;poor survival;;progression;poor survival; colon cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;bladder cancer;colorectal cancer;colorectal cancer;colorectal cancer;lung squamous cell cancer hsa-miR-140-3p KRAS 0.989350547007025 6.14964028267239e-25 -0.255817061539648 9.1459633191595e-05 MirTarget -0.108294077444579 0.00207293957432564 NA NA NA hsa-miR-193a-3p KRAS 0.849206638484406 3.68101781083335e-14 -0.255817061539648 9.1459633191595e-05 MirTarget;miRanda;miRNATAP -0.128321272108433 3.45488258543067e-05 NA NA NA hsa-miR-193a-5p KRAS 1.29777740059595 2.16815694068336e-39 -0.255817061539648 9.1459633191595e-05 miRNATAP -0.131260938035955 4.98455580646047e-05 NA NA NA hsa-miR-27a-3p KRAS 0.558934437526245 1.44256383086177e-12 -0.255817061539648 9.1459633191595e-05 miRNATAP -0.185157688434118 3.18082458260436e-05 24154848;25436011 microRNA 27a functions as a tumor suppressor in esophageal squamous cell carcinoma by targeting KRAS; Furthermore we demonstrated that miR-27a binds to the 3'-untranslated region UTR of KRAS and inhibits the expression of the KRAS protein; miR-27a levels were inversely correlated with levels of KRAS mRNA and protein in ESCC specimens; Our findings suggest for the first time that miR-27a suppresses tumorigenesis of ESCC by targeting KRAS;MicroRNA 27a directly targets KRAS to inhibit cell proliferation in esophageal squamous cell carcinoma; However the expression level of the target gene KRAS was upregulated and ESCC cell proliferation was significantly inhibited following miR-27a mimic or small interfering K-ras transfection; In conclusion the present study demonstrated that the expression level of miR-27a was low in ESCC and that miR-27a directly targets the KRAS gene resulting in inhibited cell proliferation in esophageal cancer tumorigenesis; esophageal cancer;esophageal cancer hsa-miR-542-3p KRAS 0.431147917094433 0.000254981247606435 -0.255817061539648 9.1459633191595e-05 miRanda -0.102463772502373 0.00079256513841055 NA NA NA hsa-miR-125a-5p KSR1 -0.561874059994802 7.3931856356891e-13 1.78661289553411 2.65814718651189e-39 miRanda;mirMAP -0.302993970561807 0.00421305924289547 NA NA NA hsa-miR-125b-5p KSR1 -0.825456421494266 2.13029877878434e-15 1.78661289553411 2.65814718651189e-39 mirMAP -0.5414797880983 1.05202536812756e-12 NA NA NA hsa-miR-199a-5p KSR1 -1.64658415208633 1.01615659358973e-23 1.78661289553411 2.65814718651189e-39 miRanda -0.312423104089825 2.69083937696894e-11 NA NA NA hsa-miR-199b-5p KSR1 -2.39483476763681 1.04659509514884e-17 1.78661289553411 2.65814718651189e-39 miRanda -0.22293838088608 3.41665002113346e-15 NA NA NA hsa-miR-200a-3p KSR1 -1.43409013664263 2.00188483717828e-20 1.78661289553411 2.65814718651189e-39 mirMAP -0.21712779862345 2.27476592184235e-05 NA NA NA hsa-miR-200b-3p KSR1 -1.70383252137161 2.38979336321755e-30 1.78661289553411 2.65814718651189e-39 TargetScan;mirMAP -0.329952374395437 7.41469398872455e-11 NA NA NA hsa-miR-200c-3p KSR1 -5.40303134829523 2.74173143360645e-94 1.78661289553411 2.65814718651189e-39 mirMAP -0.278946357487208 3.68806125356233e-38 NA NA NA hsa-miR-30b-5p KSR1 -1.18330589477119 6.8341618466966e-27 1.78661289553411 2.65814718651189e-39 MirTarget -0.443015479871809 1.85178020284683e-10 NA NA NA hsa-miR-30c-5p KSR1 -1.08783070774238 2.02505402525786e-24 1.78661289553411 2.65814718651189e-39 MirTarget -0.258474527269232 0.000480623597260519 NA NA NA hsa-miR-335-3p KSR1 -1.36498175550207 6.84287752180534e-13 1.78661289553411 2.65814718651189e-39 mirMAP -0.267765649654108 2.07091199647525e-10 NA NA NA hsa-miR-33a-5p KSR1 -1.59840463890997 1.13487952314403e-18 1.78661289553411 2.65814718651189e-39 mirMAP -0.335144220951019 5.00749189495493e-15 NA NA NA hsa-miR-362-3p KSR1 -0.753214251798232 3.0025661608035e-07 1.78661289553411 2.65814718651189e-39 mirMAP -0.155106794410433 0.0082900841326682 NA NA NA hsa-miR-363-3p KSR1 -1.93551166555337 4.45368477487614e-32 1.78661289553411 2.65814718651189e-39 mirMAP -0.309766263775153 1.08233123612129e-11 NA NA NA hsa-miR-381-3p KSR1 -0.674906433524392 0.000234722307243307 1.78661289553411 2.65814718651189e-39 mirMAP -0.14222489338409 0.00215126246538524 NA NA NA hsa-miR-429 KSR1 -2.16569233119434 2.66862243626443e-37 1.78661289553411 2.65814718651189e-39 miRanda;mirMAP;miRNATAP -0.29445477983982 1.02398650184635e-11 NA NA NA hsa-miR-514a-3p KSR1 -3.60916038800272 7.44698991540685e-35 1.78661289553411 2.65814718651189e-39 mirMAP -0.175683075211407 3.51380261444965e-12 NA NA NA hsa-miR-532-5p KSR1 -1.09700348358668 8.34836230254408e-26 1.78661289553411 2.65814718651189e-39 mirMAP -0.525196092794239 6.55483483309116e-13 NA NA NA hsa-miR-539-5p KSR1 -1.44841597031461 8.25650852878567e-11 1.78661289553411 2.65814718651189e-39 MirTarget;mirMAP -0.190562227851373 3.8279089320452e-07 NA NA NA hsa-miR-101-3p KSR2 0.683973909682285 2.88573524246948e-15 -4.27589642965619 3.33209841748154e-42 mirMAP -1.528810886529 7.94802563144436e-13 NA NA NA hsa-miR-106b-5p KSR2 1.07509411417907 2.11739194181878e-36 -4.27589642965619 3.33209841748154e-42 mirMAP -1.80391480350243 5.63567442892953e-20 NA NA NA hsa-miR-126-5p KSR2 0.785607261431085 5.77058629454465e-13 -4.27589642965619 3.33209841748154e-42 mirMAP -1.02584581982734 2.57210578716355e-09 NA NA NA hsa-miR-1271-5p KSR2 0.900599702972936 3.07963385418853e-10 -4.27589642965619 3.33209841748154e-42 mirMAP -0.431484843606349 0.00134550029948676 NA NA NA hsa-miR-130b-5p KSR2 0.92990617673277 3.75880436852717e-12 -4.27589642965619 3.33209841748154e-42 mirMAP -0.74499307111147 1.28628340265898e-07 NA NA NA hsa-miR-132-3p KSR2 0.291409674711894 0.000912684337101876 -4.27589642965619 3.33209841748154e-42 mirMAP;miRNATAP -0.684352277267732 0.0024505353977386 NA NA NA hsa-miR-140-5p KSR2 0.504309496243674 3.09884038729031e-11 -4.27589642965619 3.33209841748154e-42 mirMAP -1.3945767178731 3.03718694849204e-08 NA NA NA hsa-miR-142-5p KSR2 1.88417391525707 1.2096808039882e-27 -4.27589642965619 3.33209841748154e-42 mirMAP -0.614117343587024 2.39854587376796e-09 NA NA NA hsa-miR-144-3p KSR2 1.4617706700291 9.18139413836375e-11 -4.27589642965619 3.33209841748154e-42 mirMAP -0.315410253110698 0.000203161020423642 NA NA NA hsa-miR-148b-3p KSR2 0.346011252093377 4.27203463315056e-06 -4.27589642965619 3.33209841748154e-42 mirMAP -0.761490135243312 0.00379956008146246 NA NA NA hsa-miR-150-5p KSR2 1.00371863159681 1.09871676395528e-09 -4.27589642965619 3.33209841748154e-42 mirMAP -0.388406321070814 0.000894858649873854 NA NA NA hsa-miR-155-5p KSR2 3.26274490570809 5.06841441826518e-51 -4.27589642965619 3.33209841748154e-42 mirMAP -0.507229651595489 1.7534055156637e-11 NA NA NA hsa-miR-17-5p KSR2 0.494260110870015 3.8348005261e-09 -4.27589642965619 3.33209841748154e-42 mirMAP -0.931221802267779 5.69664469724641e-05 NA NA NA hsa-miR-181a-2-3p KSR2 0.549613348249471 1.48987286432989e-10 -4.27589642965619 3.33209841748154e-42 mirMAP -1.06068035624368 2.17810327180062e-06 NA NA NA hsa-miR-181b-5p KSR2 1.49054296272357 3.69051660739368e-41 -4.27589642965619 3.33209841748154e-42 mirMAP -1.34056356639249 2.25869547698947e-19 NA NA NA hsa-miR-185-5p KSR2 1.05056378692621 1.31174187880682e-22 -4.27589642965619 3.33209841748154e-42 mirMAP -1.06445158719216 2.82940330025015e-10 NA NA NA hsa-miR-186-5p KSR2 0.507217561043443 9.04455748270995e-10 -4.27589642965619 3.33209841748154e-42 mirMAP -0.849354147022147 0.000293148286267561 NA NA NA hsa-miR-193b-5p KSR2 0.277625648727715 0.101981573602756 -4.27589642965619 3.33209841748154e-42 mirMAP -0.312416042604811 0.00840657153720011 NA NA NA hsa-miR-194-5p KSR2 0.62222617402691 0.00659826803316099 -4.27589642965619 3.33209841748154e-42 mirMAP -0.263925815624376 0.0021354535645725 NA NA NA hsa-miR-196a-5p KSR2 0.440858887700369 2.0077143292463e-05 -4.27589642965619 3.33209841748154e-42 mirMAP -0.59295390191439 0.00182271932441917 NA NA NA hsa-miR-20a-5p KSR2 0.702602695798242 4.06372887613329e-13 -4.27589642965619 3.33209841748154e-42 mirMAP -1.07855778390307 3.10706374351528e-08 NA NA NA hsa-miR-21-5p KSR2 2.51462371613332 3.30620591950316e-66 -4.27589642965619 3.33209841748154e-42 mirMAP -1.00326909271199 2.4664681548789e-22 NA NA NA hsa-miR-223-3p KSR2 1.23291409735619 1.07767240442694e-17 -4.27589642965619 3.33209841748154e-42 mirMAP -0.767470043976391 1.96680377254564e-09 NA NA NA hsa-miR-2355-5p KSR2 1.57515081110162 3.54962327490702e-48 -4.27589642965619 3.33209841748154e-42 mirMAP -1.59358399552813 6.14537000687433e-28 NA NA NA hsa-miR-23a-3p KSR2 0.761438723382355 4.09310879199257e-27 -4.27589642965619 3.33209841748154e-42 mirMAP -1.77351536496838 2.62352488568727e-12 NA NA NA hsa-miR-25-3p KSR2 1.12016166564779 3.79069348635778e-48 -4.27589642965619 3.33209841748154e-42 miRNATAP -2.09408370519933 1.06034138006526e-23 NA NA NA hsa-miR-32-5p KSR2 0.407826130035097 7.26884631998646e-06 -4.27589642965619 3.33209841748154e-42 miRNATAP -1.12194966315194 1.4991447417996e-07 NA NA NA hsa-miR-320a KSR2 0.412740558379182 2.02929519701706e-05 -4.27589642965619 3.33209841748154e-42 mirMAP -0.691337410373207 0.000660281643506317 NA NA NA hsa-miR-330-3p KSR2 0.912906550436308 3.35037014057665e-13 -4.27589642965619 3.33209841748154e-42 mirMAP -0.904341825209856 3.1161407624747e-09 NA NA NA hsa-miR-330-5p KSR2 1.44960468659754 2.12131210588035e-45 -4.27589642965619 3.33209841748154e-42 miRNATAP -1.37230825268784 1.01059357864269e-17 NA NA NA hsa-miR-342-3p KSR2 1.4124432570595 1.07208971556131e-28 -4.27589642965619 3.33209841748154e-42 mirMAP -0.972948139813102 2.07470512386181e-12 NA NA NA hsa-miR-342-5p KSR2 1.37011183051517 4.99462376051624e-28 -4.27589642965619 3.33209841748154e-42 mirMAP -0.977251345693431 4.85156856859581e-12 NA NA NA hsa-miR-361-3p KSR2 1.08992546227594 1.13197240706704e-36 -4.27589642965619 3.33209841748154e-42 mirMAP -1.66075451442547 3.21987574796361e-17 NA NA NA hsa-miR-374a-3p KSR2 1.13863935833993 2.79089304015401e-44 -4.27589642965619 3.33209841748154e-42 mirMAP -1.97720721493892 2.8876103498409e-23 NA NA NA hsa-miR-374b-3p KSR2 0.611842481331529 3.85718194756943e-07 -4.27589642965619 3.33209841748154e-42 mirMAP -0.774213741522012 3.10401927766924e-06 NA NA NA hsa-miR-421 KSR2 0.313155739887734 0.020433534776003 -4.27589642965619 3.33209841748154e-42 mirMAP -0.441374294746193 0.00355495578515091 NA NA NA hsa-miR-423-5p KSR2 0.250929012519631 0.00288495915028486 -4.27589642965619 3.33209841748154e-42 mirMAP -0.825383123235931 0.000465597908624508 NA NA NA hsa-miR-452-3p KSR2 1.72039996672257 1.35748079442153e-22 -4.27589642965619 3.33209841748154e-42 mirMAP -0.742487656111187 8.56183707691568e-13 NA NA NA hsa-miR-452-5p KSR2 2.05325688842141 2.82238393643084e-40 -4.27589642965619 3.33209841748154e-42 mirMAP -0.972293023442274 8.27757292651553e-20 NA NA NA hsa-miR-455-5p KSR2 0.773674551205946 2.12957541541474e-09 -4.27589642965619 3.33209841748154e-42 mirMAP -1.0080280299614 4.06034711039519e-12 NA NA NA hsa-miR-486-5p KSR2 1.16748143760361 1.68410465883829e-08 -4.27589642965619 3.33209841748154e-42 mirMAP -0.283231123537189 0.00243840587286166 NA NA NA hsa-miR-550a-3p KSR2 1.11969632674498 4.64306608686e-12 -4.27589642965619 3.33209841748154e-42 mirMAP -0.537612289535591 2.46715798381181e-05 NA NA NA hsa-miR-589-5p KSR2 0.696241532021631 5.26958362886071e-16 -4.27589642965619 3.33209841748154e-42 mirMAP -1.28327081345337 3.60330610829996e-09 NA NA NA hsa-miR-590-3p KSR2 1.13702599385212 3.53435739887793e-22 -4.27589642965619 3.33209841748154e-42 mirMAP -1.08524785844181 1.51129871378484e-12 NA NA NA hsa-miR-590-5p KSR2 0.709763558412506 1.11883921359361e-11 -4.27589642965619 3.33209841748154e-42 mirMAP -1.1254957685975 4.07650281494962e-10 NA NA NA hsa-miR-592 KSR2 2.6404220268798 8.81369998128794e-32 -4.27589642965619 3.33209841748154e-42 mirMAP -0.54209151971433 2.96153113474278e-12 NA NA NA hsa-miR-616-5p KSR2 0.913426384742148 3.78418389333709e-09 -4.27589642965619 3.33209841748154e-42 mirMAP;miRNATAP -0.487316268617843 0.000113256904897742 NA NA NA hsa-miR-629-3p KSR2 1.09330044556689 2.9533160808356e-14 -4.27589642965619 3.33209841748154e-42 mirMAP -0.756925308226703 1.00973363486884e-08 NA NA NA hsa-miR-629-5p KSR2 1.73389921851483 5.39614356468007e-48 -4.27589642965619 3.33209841748154e-42 mirMAP -1.52291911770059 1.33609336732751e-31 NA NA NA hsa-miR-769-5p KSR2 0.376837385738096 4.45440414144944e-07 -4.27589642965619 3.33209841748154e-42 mirMAP -1.38501548408573 1.0490103607667e-07 NA NA NA hsa-miR-92a-3p KSR2 0.178194888895831 0.0088835082650834 -4.27589642965619 3.33209841748154e-42 miRNATAP -0.829814661117127 0.00494947877642616 NA NA NA hsa-miR-99b-3p KSR2 0.28189032441154 2.0968969830339e-05 -4.27589642965619 3.33209841748154e-42 mirMAP -1.17485816806947 8.73101335125363e-05 NA NA NA hsa-let-7a-3p MAPK1 0.0677487960013088 0.460458477653989 0.0752350253994916 0.244227817396104 mirMAP -0.120937214673988 0.00189910022756462 NA NA NA hsa-miR-221-3p MAPK1 0.337895669520713 0.0136448974691037 0.0752350253994916 0.244227817396104 mirMAP -0.18533006750384 1.05774724669662e-13 NA NA NA hsa-miR-222-3p MAPK1 0.214811008033524 0.0965295551752457 0.0752350253994916 0.244227817396104 mirMAP -0.111381984547009 4.49766515770734e-05 NA NA NA hsa-miR-29a-3p MAPK1 -0.431613225927952 4.10166815070288e-08 0.0752350253994916 0.244227817396104 mirMAP -0.199785129647306 6.26938786529944e-06 NA NA NA hsa-miR-29c-3p MAPK1 -0.238671318446745 0.0141475322347596 0.0752350253994916 0.244227817396104 mirMAP -0.118476374132015 0.00117661250325827 NA NA NA hsa-miR-30b-5p MAPK1 -1.18330589477119 6.8341618466966e-27 0.0752350253994916 0.244227817396104 mirMAP -0.126400578163208 1.7728740776704e-05 NA NA NA hsa-miR-130b-3p MAPK10 1.12788913578446 2.939369462276e-16 -1.21487132791135 4.28083849239698e-29 miRNATAP -0.426865766422543 6.2125228747084e-24 NA NA NA hsa-miR-146b-5p MAPK10 1.40714170253819 2.9559871816487e-12 -1.21487132791135 4.28083849239698e-29 miRanda -0.238154498396656 2.40916717729571e-15 NA NA NA hsa-miR-193a-3p MAPK10 0.849206638484406 3.68101781083335e-14 -1.21487132791135 4.28083849239698e-29 miRanda;miRNATAP -0.477791684724428 3.60529507654292e-19 NA NA NA hsa-miR-19a-3p MAPK10 0.722913586880779 2.76301458932381e-10 -1.21487132791135 4.28083849239698e-29 miRNATAP -0.350806870796812 1.13510508025726e-10 NA NA NA hsa-miR-19b-3p MAPK10 0.195940928879427 0.0300512922542325 -1.21487132791135 4.28083849239698e-29 miRNATAP -0.309366846213377 1.96850100098747e-05 NA NA NA hsa-miR-221-3p MAPK10 0.337895669520713 0.0136448974691037 -1.21487132791135 4.28083849239698e-29 miRNATAP -0.257156072087272 4.41278059795946e-08 NA NA NA hsa-miR-222-3p MAPK10 0.214811008033524 0.0965295551752457 -1.21487132791135 4.28083849239698e-29 miRNATAP -0.299797013226272 1.63347653838624e-09 NA NA NA hsa-miR-29b-3p MAPK10 -0.228125979913806 0.0271621721891603 -1.21487132791135 4.28083849239698e-29 miRNATAP -0.196078455627514 0.00205832566182426 24767251 The percentage of positive myeloid cell leukemia sequence 1 ATG9A and MAPK10 protein expression and low miR-29b mRNA expression were significantly higher in cases with clinical stage III and IV ovarian cancer than in cases with clinical stage II ovarian cancer; Univariate Kaplan-Meier analysis showed a negative correlation between MAPK10 or ATG9A protein expression and overall as well as progression-free survival whereas a positive correlation was observed between miR-29b mRNA expression and overall as well as progression-free survival; Multivariate Cox regression analysis showed that elevated MAPK10 or ATG9A protein and lowered miR-29b mRNA expression in ovarian carcinoma was an independent poor prognostic predictor; Our study suggested that miR-29b mRNA MAPK10 protein expression and ATG9A protein expression are closely related to chemosensitivity of ovarian carcinoma staging;progression;poor survival ovarian cancer hsa-miR-301a-3p MAPK10 0.259400847075798 0.0216890736701418 -1.21487132791135 4.28083849239698e-29 miRNATAP -0.206875912734593 0.000352634513303849 NA NA NA hsa-miR-330-3p MAPK10 0.912906550436308 3.35037014057665e-13 -1.21487132791135 4.28083849239698e-29 PITA;miRNATAP -0.23056537801525 6.24801819994022e-06 NA NA NA hsa-miR-454-3p MAPK10 0.68285296887698 1.17407812677787e-08 -1.21487132791135 4.28083849239698e-29 miRNATAP -0.340810695000248 7.01951489670639e-11 NA NA NA hsa-miR-590-3p MAPK10 1.13702599385212 3.53435739887793e-22 -1.21487132791135 4.28083849239698e-29 miRanda;mirMAP -0.400723704396593 1.46142734104843e-15 NA NA NA hsa-miR-590-5p MAPK10 0.709763558412506 1.11883921359361e-11 -1.21487132791135 4.28083849239698e-29 PITA;miRanda;miRNATAP -0.384956181913074 9.15169986554425e-11 NA NA NA hsa-let-7a-3p MAPK8 0.0677487960013088 0.460458477653989 -0.750160075359857 1.06943990640368e-11 mirMAP -0.224745732614521 0.00113114965599641 NA NA NA hsa-let-7f-1-3p MAPK8 0.477913872379336 4.46669616865068e-05 -0.750160075359857 1.06943990640368e-11 mirMAP -0.198193629510422 0.000578100841933834 NA NA NA hsa-miR-130b-3p MAPK8 1.12788913578446 2.939369462276e-16 -0.750160075359857 1.06943990640368e-11 mirMAP -0.300046383602671 1.12283314104074e-12 NA NA NA hsa-miR-140-3p MAPK8 0.989350547007025 6.14964028267239e-25 -0.750160075359857 1.06943990640368e-11 miRNAWalker2_validate -0.21607071391855 0.000381512783937793 NA NA NA hsa-miR-16-2-3p MAPK8 1.3046118743965 4.17207934608428e-19 -0.750160075359857 1.06943990640368e-11 mirMAP -0.230603960728852 7.35216005494181e-09 NA NA NA hsa-miR-193b-3p MAPK8 -0.273325765316079 0.104328826585392 -0.750160075359857 1.06943990640368e-11 miRNAWalker2_validate -0.115617600028936 0.00194240080077243 NA NA NA hsa-miR-22-5p MAPK8 -0.197038086012602 0.106234828461117 -0.750160075359857 1.06943990640368e-11 mirMAP -0.269908296695586 1.14728279558826e-07 NA NA NA hsa-miR-374a-3p MAPK8 1.13863935833993 2.79089304015401e-44 -0.750160075359857 1.06943990640368e-11 mirMAP -0.289709574010348 1.55055266358389e-05 NA NA NA hsa-miR-590-3p MAPK8 1.13702599385212 3.53435739887793e-22 -0.750160075359857 1.06943990640368e-11 miRNATAP -0.262993606467664 1.07257214255814e-07 NA NA NA hsa-miR-24-3p MAPK9 0.173813044685099 0.00565259443420961 0.14417034408476 0.00521298953478229 miRNATAP -0.189071350720719 3.44779387721655e-05 NA NA NA hsa-miR-27b-3p MAPK9 -0.699527231242518 1.07356023759234e-15 0.14417034408476 0.00521298953478229 miRNAWalker2_validate -0.147750560718002 1.80817169396102e-06 NA NA NA hsa-miR-125a-3p MET -0.372794471295036 0.000941729459601642 1.10521139840773 5.81097310030977e-21 miRanda -0.284444298057698 2.77787407081191e-06 NA NA NA hsa-miR-127-3p MET -1.21389348740811 1.68387193137287e-11 1.10521139840773 5.81097310030977e-21 miRanda -0.174598343093179 1.95935669805614e-06 NA NA NA hsa-miR-130a-3p MET -0.667386596699886 1.34029167767774e-10 1.10521139840773 5.81097310030977e-21 miRNAWalker2_validate -0.22362307667284 0.000557058482784787 NA NA NA hsa-miR-139-5p MET -0.704802495091118 2.36904108453776e-06 1.10521139840773 5.81097310030977e-21 miRanda -0.246239292765101 4.1364380758207e-08 NA NA NA hsa-miR-199a-3p MET -1.61607426368083 1.97964980193147e-26 1.10521139840773 5.81097310030977e-21 miRNAWalker2_validate;miRTarBase -0.231567821676256 1.91977917623346e-08 21055388;25839163 16 2002 3074-3086 and c-Met is a known miR-199a-3p target we hypothesized that miR-199a-3p may also target CD44;In silico analyses indicated that MET is one of the target genes for miR-199a-3p; subsequently miR-199a-3p expression was found to be inversely correlated with c-Met expression in ovarian cancer; Transfection of precursor miR-199a-3p into ovarian cancer cells reduced c-Met expression and inhibited the phosphorylation of c-Met extracellular signal-regulated kinase and AKT; in addition proliferation adhesion and invasiveness were inhibited; In summary the hypoxia-related microRNA miR-199a-3p drastically inhibits ovarian cancer progression through the downregulation of c-Met expression ;progression liver cancer;ovarian cancer hsa-miR-23b-3p MET -0.533749586990474 2.46924776953771e-10 1.10521139840773 5.81097310030977e-21 miRNAWalker2_validate;miRTarBase -0.288449648692482 0.000322376434190187 19490101 MicroRNA 23b mediates urokinase and c met downmodulation and a decreased migration of human hepatocellular carcinoma cells; In the present study to understand whether the expression of these genes might be coregulated by specific microRNAs miRs in human cells we predicted that Homo sapiens microRNA-23b could recognize two sites in the 3'-UTR of uPA and four sites in the c-met 3'-UTR by the algorithm pictar; The evidence obtained shows that overexpression of miR-23b leads to uPA and c-met downregulation and to decreased migration and proliferation abilities of HCC cells liver cancer hsa-miR-30a-3p MET -0.955360819934585 1.97009535429185e-20 1.10521139840773 5.81097310030977e-21 mirMAP -0.223584517664621 0.000396332171778455 NA NA NA hsa-miR-30d-3p MET -0.249777194282131 0.00235356711813496 1.10521139840773 5.81097310030977e-21 mirMAP -0.262253658982834 0.00194187018539678 NA NA NA hsa-miR-30e-3p MET -0.205602546270795 0.00132666419729688 1.10521139840773 5.81097310030977e-21 mirMAP -0.350613138955605 0.00135280320964367 NA NA NA hsa-miR-361-5p MET 0.0514169367202078 0.382929376393199 1.10521139840773 5.81097310030977e-21 PITA;miRanda -0.39809738988012 0.0009365276679273 NA NA NA hsa-miR-362-3p MET -0.753214251798232 3.0025661608035e-07 1.10521139840773 5.81097310030977e-21 miRanda -0.235463896413951 5.79434472506528e-07 NA NA NA hsa-miR-374b-5p MET 0.0804104684417872 0.365593963035077 1.10521139840773 5.81097310030977e-21 mirMAP -0.227462487419821 0.00381082169623714 NA NA NA hsa-miR-532-3p MET -1.759223962964 7.9077916669414e-40 1.10521139840773 5.81097310030977e-21 PITA -0.339739753385223 1.34105177061007e-14 NA NA NA hsa-let-7b-5p MRAS 0.770868211539597 6.63408323707647e-21 -0.554669193598587 1.52363396365892e-08 mirMAP -0.23615819907007 0.000193405187111281 NA NA NA hsa-miR-15a-5p MRAS 1.42663930007845 1.36006952074963e-57 -0.554669193598587 1.52363396365892e-08 miRNATAP -0.231362633411201 6.99096086029183e-06 NA NA NA hsa-miR-16-5p MRAS 0.934012514027655 4.85417898318515e-24 -0.554669193598587 1.52363396365892e-08 miRNATAP -0.152352262008386 0.00643137849661952 NA NA NA hsa-miR-330-5p MRAS 1.44960468659754 2.12131210588035e-45 -0.554669193598587 1.52363396365892e-08 miRanda -0.160562688895322 0.000591299493148386 NA NA NA hsa-miR-338-3p MRAS 0.906250377628867 2.76970900371139e-15 -0.554669193598587 1.52363396365892e-08 miRanda -0.176764185931236 0.000119202735511636 NA NA NA hsa-let-7a-3p NF1 0.0677487960013088 0.460458477653989 -0.278582655858325 3.19619777018965e-05 mirMAP -0.16583406341185 4.5517347241611e-05 NA NA NA hsa-let-7f-1-3p NF1 0.477913872379336 4.46669616865068e-05 -0.278582655858325 3.19619777018965e-05 mirMAP -0.113626683455709 0.000862952146948667 NA NA NA hsa-miR-103a-3p NF1 0.779373475434461 7.37867196796994e-20 -0.278582655858325 3.19619777018965e-05 MirTarget -0.132358328711865 0.0013497057752787 NA NA NA hsa-miR-128-3p NF1 0.475045893035043 2.6255647468e-06 -0.278582655858325 3.19619777018965e-05 MirTarget -0.11265279417326 0.00198752649104985 NA NA NA hsa-miR-15a-5p NF1 1.42663930007845 1.36006952074963e-57 -0.278582655858325 3.19619777018965e-05 MirTarget -0.158221764357537 5.06318712030949e-06 NA NA NA hsa-miR-15b-5p NF1 0.773001494057531 1.71784656078957e-16 -0.278582655858325 3.19619777018965e-05 MirTarget -0.136525136861035 0.000313808033418001 NA NA NA hsa-miR-193a-3p NF1 0.849206638484406 3.68101781083335e-14 -0.278582655858325 3.19619777018965e-05 miRanda -0.178191979159234 1.44209785114945e-08 NA NA NA hsa-miR-27a-3p NF1 0.558934437526245 1.44256383086177e-12 -0.278582655858325 3.19619777018965e-05 MirTarget -0.291452353781108 7.83292657919896e-11 NA NA NA hsa-miR-28-5p NF1 0.461962042257226 3.32424690573327e-11 -0.278582655858325 3.19619777018965e-05 miRanda -0.261029606371927 4.95406042023725e-07 NA NA NA hsa-miR-330-5p NF1 1.44960468659754 2.12131210588035e-45 -0.278582655858325 3.19619777018965e-05 miRanda -0.116269768237763 0.00021849086941097 NA NA NA hsa-miR-590-3p NF1 1.13702599385212 3.53435739887793e-22 -0.278582655858325 3.19619777018965e-05 MirTarget;PITA;miRanda;miRNATAP -0.120520490418901 4.5428332941545e-05 NA NA NA hsa-miR-590-5p NF1 0.709763558412506 1.11883921359361e-11 -0.278582655858325 3.19619777018965e-05 miRanda -0.146874585973214 1.90748914030311e-05 NA NA NA hsa-let-7g-5p NGF -0.739744008507763 1.07979566264383e-14 1.68176218451818 4.25883926715749e-21 MirTarget -0.604104636667389 5.7443559092026e-09 NA NA NA hsa-miR-429 NGF -2.16569233119434 2.66862243626443e-37 1.68176218451818 4.25883926715749e-21 miRanda -0.274846404242145 4.10102515693054e-07 NA NA NA hsa-miR-148b-5p NGFR 0.269550343699955 0.0383631776794927 1.73595423231764 2.74915553479934e-17 mirMAP -0.258433454043494 0.00635621942669257 NA NA NA hsa-miR-30b-3p NGFR -1.64703050862226 1.89878531036464e-31 1.73595423231764 2.74915553479934e-17 mirMAP -0.447874831071752 3.12016672638388e-09 NA NA NA hsa-miR-335-5p NGFR -2.09515619961552 1.03765771499548e-25 1.73595423231764 2.74915553479934e-17 miRNAWalker2_validate -0.273692690787194 6.2535727522281e-07 NA NA NA hsa-miR-429 NGFR -2.16569233119434 2.66862243626443e-37 1.73595423231764 2.74915553479934e-17 miRNATAP -0.257757541818778 3.27230306859199e-05 NA NA NA hsa-miR-625-5p NGFR 0.153090549230629 0.330314026509869 1.73595423231764 2.74915553479934e-17 mirMAP -0.38340250894736 2.51016761080774e-06 NA NA NA hsa-miR-766-3p NGFR -0.230617949950715 0.0566289375252083 1.73595423231764 2.74915553479934e-17 mirMAP -0.54139859448209 2.47996756160292e-08 NA NA NA hsa-miR-26a-5p NRAS -0.202091714279613 0.00166918288801054 0.34448791512356 4.92740995926564e-07 mirMAP;miRNATAP -0.190676842662057 0.00158798186993403 26458859 MiR 26a enhances the sensitivity of gastric cancer cells to cisplatin by targeting NRAS and E2F2; Our results suggest that miR-26a can improve the sensitivity of GC cells to cisplatin-based chemotherapies through targeting NRAS and E2F2 and provide the first evidence of the potential utility of miR-26a as a sensitizer in chemotherapy for GC gastric cancer hsa-miR-27b-3p NRAS -0.699527231242518 1.07356023759234e-15 0.34448791512356 4.92740995926564e-07 miRNATAP -0.133554182026992 0.00155260770161313 NA NA NA hsa-miR-29a-3p NRAS -0.431613225927952 4.10166815070288e-08 0.34448791512356 4.92740995926564e-07 miRNATAP -0.260252250919602 4.11630497908065e-08 NA NA NA hsa-miR-29c-3p NRAS -0.238671318446745 0.0141475322347596 0.34448791512356 4.92740995926564e-07 miRNATAP -0.171085903480696 1.27586236636451e-05 NA NA NA hsa-miR-502-3p NRAS -1.10416310320528 1.55354569985732e-22 0.34448791512356 4.92740995926564e-07 MirTarget -0.127167715752408 5.47705696881981e-05 NA NA NA hsa-miR-142-3p NTF3 1.88928758773299 2.72985643829893e-22 -0.668855124592218 0.000140030636687871 miRanda -0.192970372635885 3.40296027412e-05 NA NA NA hsa-miR-21-5p NTF3 2.51462371613332 3.30620591950316e-66 -0.668855124592218 0.000140030636687871 miRTarBase;miRNATAP -0.202004999552495 0.000189117552740546 NA NA NA hsa-miR-221-3p NTF3 0.337895669520713 0.0136448974691037 -0.668855124592218 0.000140030636687871 miRNATAP -0.191983307441267 0.00712732397760743 NA NA NA hsa-miR-222-3p NTF3 0.214811008033524 0.0965295551752457 -0.668855124592218 0.000140030636687871 miRNATAP -0.286460458871947 0.000146481856047174 NA NA NA hsa-miR-590-3p NTF3 1.13702599385212 3.53435739887793e-22 -0.668855124592218 0.000140030636687871 miRanda -0.280720029817671 0.000312503544564494 NA NA NA hsa-miR-590-5p NTF3 0.709763558412506 1.11883921359361e-11 -0.668855124592218 0.000140030636687871 PITA;miRanda;miRNATAP -0.379489466442206 2.6461671900719e-05 NA NA NA hsa-miR-16-1-3p NTRK1 1.51429140700091 3.17219833254498e-37 -2.16917617916044 3.29741000934657e-22 mirMAP -0.547850527770562 3.2373436730389e-08 NA NA NA hsa-miR-185-3p NTRK1 0.993379985307475 2.62011454953707e-13 -2.16917617916044 3.29741000934657e-22 MirTarget -0.306701824990764 0.00125082909655452 NA NA NA hsa-miR-1271-5p NTRK2 0.900599702972936 3.07963385418853e-10 -2.73321393169747 3.3903895709546e-27 mirMAP -0.279489318800296 0.00692601449421045 NA NA NA hsa-miR-130b-3p NTRK2 1.12788913578446 2.939369462276e-16 -2.73321393169747 3.3903895709546e-27 mirMAP -0.726248428792849 1.06613529740873e-12 NA NA NA hsa-miR-130b-5p NTRK2 0.92990617673277 3.75880436852717e-12 -2.73321393169747 3.3903895709546e-27 mirMAP -0.664853909431365 5.97557240278784e-10 NA NA NA hsa-miR-140-3p NTRK2 0.989350547007025 6.14964028267239e-25 -2.73321393169747 3.3903895709546e-27 PITA -0.519386335791164 0.000414092080713394 NA NA NA hsa-miR-140-5p NTRK2 0.504309496243674 3.09884038729031e-11 -2.73321393169747 3.3903895709546e-27 miRanda -0.602681306142158 0.00214343631834989 NA NA NA hsa-miR-142-3p NTRK2 1.88928758773299 2.72985643829893e-22 -2.73321393169747 3.3903895709546e-27 miRanda -0.535926145944065 2.20805593228617e-14 NA NA NA hsa-miR-142-5p NTRK2 1.88417391525707 1.2096808039882e-27 -2.73321393169747 3.3903895709546e-27 mirMAP -0.630558350878623 2.91820135052768e-16 NA NA NA hsa-miR-146b-5p NTRK2 1.40714170253819 2.9559871816487e-12 -2.73321393169747 3.3903895709546e-27 PITA;miRanda -0.530011528937097 3.93751534627944e-14 NA NA NA hsa-miR-148a-5p NTRK2 0.415500302855613 0.000691460831436767 -2.73321393169747 3.3903895709546e-27 mirMAP -0.405140262998007 0.00102752820872671 NA NA NA hsa-miR-150-5p NTRK2 1.00371863159681 1.09871676395528e-09 -2.73321393169747 3.3903895709546e-27 mirMAP -0.350808561928945 8.73868933597758e-05 NA NA NA hsa-miR-155-5p NTRK2 3.26274490570809 5.06841441826518e-51 -2.73321393169747 3.3903895709546e-27 mirMAP -0.523772868638065 9.71166995832331e-21 NA NA NA hsa-miR-15b-3p NTRK2 1.49422666971434 5.44139893275088e-29 -2.73321393169747 3.3903895709546e-27 mirMAP -0.883103230853508 3.54431200556926e-19 NA NA NA hsa-miR-17-3p NTRK2 0.723795600017259 5.90151677164931e-18 -2.73321393169747 3.3903895709546e-27 miRNATAP -0.896939124509083 1.53151658135195e-07 NA NA NA hsa-miR-181a-5p NTRK2 1.11111114875339 3.97880443756442e-29 -2.73321393169747 3.3903895709546e-27 mirMAP -0.733342857770367 1.20516883867811e-07 NA NA NA hsa-miR-181b-5p NTRK2 1.49054296272357 3.69051660739368e-41 -2.73321393169747 3.3903895709546e-27 mirMAP -0.862482081682885 1.35863838260511e-13 NA NA NA hsa-miR-185-5p NTRK2 1.05056378692621 1.31174187880682e-22 -2.73321393169747 3.3903895709546e-27 mirMAP -0.903531978686805 2.07831492195628e-12 NA NA NA hsa-miR-186-5p NTRK2 0.507217561043443 9.04455748270995e-10 -2.73321393169747 3.3903895709546e-27 mirMAP -0.751111378776912 2.81517737650002e-05 NA NA NA hsa-miR-21-5p NTRK2 2.51462371613332 3.30620591950316e-66 -2.73321393169747 3.3903895709546e-27 mirMAP -0.866304204214476 4.74626449144815e-29 NA NA NA hsa-miR-22-3p NTRK2 0.198460552200729 0.00761005672059428 -2.73321393169747 3.3903895709546e-27 miRNATAP -0.940887284040991 4.26647718326073e-06 27662840 NTRK2 is an oncogene and associated with microRNA 22 regulation in human gastric cancer cell lines; The upstream regulator of NTRK2 microRNA-22 miR-22 was evaluated by dual-luciferase assay; In miR-22-upregulated MKN-28 and SNU-719 cells NTRK2 was further overexpressed to evaluate functional interaction between miR-22 and NTRK2 in GC; MiR-22 was verified to be an inverse upstream regulator of NTRK2; NTRK2 is an oncogene and reversely associated with miR-22 in regulating in vitro cancer development in GC gastric cancer hsa-miR-224-3p NTRK2 0.918780460857403 2.47005991706282e-07 -2.73321393169747 3.3903895709546e-27 mirMAP -0.296880246942849 0.000601419642883547 NA NA NA hsa-miR-28-3p NTRK2 1.01277915413238 1.8655970171461e-43 -2.73321393169747 3.3903895709546e-27 mirMAP -1.55284291020704 3.13155796248004e-19 NA NA NA hsa-miR-301a-3p NTRK2 0.259400847075798 0.0216890736701418 -2.73321393169747 3.3903895709546e-27 mirMAP -0.404742958628509 0.00266401330037096 NA NA NA hsa-miR-32-5p NTRK2 0.407826130035097 7.26884631998646e-06 -2.73321393169747 3.3903895709546e-27 mirMAP -0.598949064606831 0.000301224488907791 NA NA NA hsa-miR-330-5p NTRK2 1.44960468659754 2.12131210588035e-45 -2.73321393169747 3.3903895709546e-27 miRanda -0.967842612453671 5.88353202789705e-15 NA NA NA hsa-miR-339-5p NTRK2 0.322848334531193 0.0117281778821612 -2.73321393169747 3.3903895709546e-27 miRanda -0.535957387929389 5.05171729322507e-06 NA NA NA hsa-miR-340-5p NTRK2 1.14479851941741 2.91936881701444e-15 -2.73321393169747 3.3903895709546e-27 mirMAP -0.399071788262657 6.273974375913e-05 NA NA NA hsa-miR-342-3p NTRK2 1.4124432570595 1.07208971556131e-28 -2.73321393169747 3.3903895709546e-27 miRanda -0.756935028269671 9.6439214022446e-13 NA NA NA hsa-miR-374a-5p NTRK2 0.543061152108237 2.19403097299769e-14 -2.73321393169747 3.3903895709546e-27 mirMAP -0.782462980478737 0.000158244892407905 NA NA NA hsa-miR-452-3p NTRK2 1.72039996672257 1.35748079442153e-22 -2.73321393169747 3.3903895709546e-27 mirMAP -0.530028502444608 3.6645564067277e-11 NA NA NA hsa-miR-452-5p NTRK2 2.05325688842141 2.82238393643084e-40 -2.73321393169747 3.3903895709546e-27 mirMAP -0.627797662843897 5.64553003041051e-14 NA NA NA hsa-miR-454-3p NTRK2 0.68285296887698 1.17407812677787e-08 -2.73321393169747 3.3903895709546e-27 mirMAP -0.687524402930162 1.88953043418862e-08 NA NA NA hsa-miR-576-5p NTRK2 1.06681109513983 5.69294424466526e-24 -2.73321393169747 3.3903895709546e-27 PITA;mirMAP -0.776948309330999 3.45345465514776e-09 NA NA NA hsa-miR-590-3p NTRK2 1.13702599385212 3.53435739887793e-22 -2.73321393169747 3.3903895709546e-27 PITA;miRanda;mirMAP -1.00386450655333 3.56539151155473e-18 NA NA NA hsa-miR-590-5p NTRK2 0.709763558412506 1.11883921359361e-11 -2.73321393169747 3.3903895709546e-27 miRanda;mirMAP -0.969172844259923 1.50709586782717e-12 NA NA NA hsa-miR-140-3p PAK2 0.989350547007025 6.14964028267239e-25 -0.0396753863732426 0.470587814692617 MirTarget;PITA;miRNATAP -0.103698735378074 0.000365655454195812 NA NA NA hsa-miR-26a-5p PAK2 -0.202091714279613 0.00166918288801054 -0.0396753863732426 0.470587814692617 MirTarget;miRNATAP -0.16141245794453 0.000654700712994406 NA NA NA hsa-miR-361-5p PAK2 0.0514169367202078 0.382929376393199 -0.0396753863732426 0.470587814692617 mirMAP -0.178324393753364 0.000649974256073914 NA NA NA hsa-miR-361-5p PAK3 0.0514169367202078 0.382929376393199 -0.098019430738149 0.688455492282651 miRanda -0.878953059607519 0.00016879681540517 NA NA NA hsa-miR-455-5p PAK3 0.773674551205946 2.12957541541474e-09 -0.098019430738149 0.688455492282651 miRanda -0.37454396604151 0.000221146757821014 NA NA NA hsa-miR-181a-5p PAK4 1.11111114875339 3.97880443756442e-29 -0.490531101207345 5.7532261692961e-10 miRNATAP -0.213959733700283 1.57046133238845e-07 NA NA NA hsa-miR-181b-5p PAK4 1.49054296272357 3.69051660739368e-41 -0.490531101207345 5.7532261692961e-10 miRNATAP -0.194122726027436 2.73769401666132e-08 NA NA NA hsa-miR-1270 PAK6 1.71697026896618 1.75919401373445e-16 -4.86987634026422 4.07789548061978e-71 miRNATAP -0.7819044453894 3.96580679662811e-22 NA NA NA hsa-miR-130b-3p PAK6 1.12788913578446 2.939369462276e-16 -4.86987634026422 4.07789548061978e-71 miRNATAP -0.900940817907039 9.73371431747647e-13 NA NA NA hsa-miR-185-5p PAK6 1.05056378692621 1.31174187880682e-22 -4.86987634026422 4.07789548061978e-71 miRNATAP -1.13362984047126 1.01663210175312e-12 NA NA NA hsa-miR-192-5p PAK6 0.442478872410106 0.0669238175123954 -4.86987634026422 4.07789548061978e-71 miRNAWalker2_validate -0.399433165041315 1.8722507842576e-07 NA NA NA hsa-miR-193a-3p PAK6 0.849206638484406 3.68101781083335e-14 -4.86987634026422 4.07789548061978e-71 miRanda -1.15017891186316 1.96350016465783e-13 NA NA NA hsa-miR-19a-3p PAK6 0.722913586880779 2.76301458932381e-10 -4.86987634026422 4.07789548061978e-71 miRNATAP -1.11130998034625 8.10550695794444e-13 NA NA NA hsa-miR-19b-3p PAK6 0.195940928879427 0.0300512922542325 -4.86987634026422 4.07789548061978e-71 miRNATAP -0.666306804586226 0.00147785552792116 NA NA NA hsa-miR-215-5p PAK6 1.57223951497888 6.18833867819653e-10 -4.86987634026422 4.07789548061978e-71 miRNAWalker2_validate -0.521941009040415 5.88324304449004e-14 NA NA NA hsa-miR-23a-3p PAK6 0.761438723382355 4.09310879199257e-27 -4.86987634026422 4.07789548061978e-71 miRNATAP -2.29672636821981 4.74214595863957e-23 25714010 Downregulation of microRNA 23a suppresses prostate cancer metastasis by targeting the PAK6 LIMK1 signaling pathway; MiR-23a decreased levels of p21-activated kinase 6 PAK6 metastasis prostate cancer hsa-miR-27a-3p PAK6 0.558934437526245 1.44256383086177e-12 -4.86987634026422 4.07789548061978e-71 miRNATAP -1.53382340709283 1.1761291139367e-11 NA NA NA hsa-miR-28-5p PAK6 0.461962042257226 3.32424690573327e-11 -4.86987634026422 4.07789548061978e-71 miRNATAP -2.03957827944447 1.3074057850796e-15 NA NA NA hsa-miR-301a-3p PAK6 0.259400847075798 0.0216890736701418 -4.86987634026422 4.07789548061978e-71 miRNATAP -0.602478727713585 0.0002924913158816 NA NA NA hsa-miR-361-3p PAK6 1.08992546227594 1.13197240706704e-36 -4.86987634026422 4.07789548061978e-71 PITA -1.89073360256317 2.85976574958849e-25 NA NA NA hsa-miR-423-5p PAK6 0.250929012519631 0.00288495915028486 -4.86987634026422 4.07789548061978e-71 miRNATAP -1.20098961579146 5.63819356066931e-08 NA NA NA hsa-miR-454-3p PAK6 0.68285296887698 1.17407812677787e-08 -4.86987634026422 4.07789548061978e-71 miRNATAP -1.08821753229402 2.80183959717526e-13 NA NA NA hsa-miR-484 PAK6 0.571987778099603 9.67278224458421e-10 -4.86987634026422 4.07789548061978e-71 mirMAP -1.24750150390477 9.02340472825112e-11 NA NA NA hsa-miR-335-3p PDGFA -1.36498175550207 6.84287752180534e-13 0.784073561233544 6.85051005668436e-15 mirMAP -0.123406397724081 2.37431234661371e-05 NA NA NA hsa-let-7g-5p PDGFB -0.739744008507763 1.07979566264383e-14 0.514864266712336 1.3417847330971e-06 miRNATAP -0.206195775236675 0.000576759591890832 NA NA NA hsa-miR-29a-3p PDGFB -0.431613225927952 4.10166815070288e-08 0.514864266712336 1.3417847330971e-06 MirTarget;miRNATAP -0.476936960397935 7.15396531394664e-11 NA NA NA hsa-miR-29b-3p PDGFB -0.228125979913806 0.0271621721891603 0.514864266712336 1.3417847330971e-06 MirTarget;miRNATAP -0.405612933369531 4.60127322330892e-13 NA NA NA hsa-miR-335-5p PDGFB -2.09515619961552 1.03765771499548e-25 0.514864266712336 1.3417847330971e-06 mirMAP -0.118392042230392 1.77239536755918e-05 NA NA NA hsa-miR-362-3p PDGFB -0.753214251798232 3.0025661608035e-07 0.514864266712336 1.3417847330971e-06 miRanda -0.149895887453564 0.000254386338042802 NA NA NA hsa-let-7f-1-3p PDGFC 0.477913872379336 4.46669616865068e-05 -0.0316307429734559 0.726012620173818 mirMAP -0.123030507985636 0.00696109914011498 NA NA NA hsa-miR-203a-3p PDGFD -2.25533513338731 1.77332845294014e-21 1.65004968079667 2.02041689804487e-26 MirTarget -0.156944311779093 1.58538197984785e-05 NA NA NA hsa-miR-335-3p PDGFD -1.36498175550207 6.84287752180534e-13 1.65004968079667 2.02041689804487e-26 mirMAP -0.362440852030351 1.06390246695021e-15 NA NA NA hsa-miR-381-3p PDGFD -0.674906433524392 0.000234722307243307 1.65004968079667 2.02041689804487e-26 MirTarget -0.202944737838563 5.58676073357791e-05 NA NA NA hsa-miR-495-3p PDGFD -0.742293735164333 7.11373308013543e-05 1.65004968079667 2.02041689804487e-26 mirMAP -0.215583875493114 1.87732298432318e-05 NA NA NA hsa-miR-9-5p PDGFD -2.23538606210968 1.28143998950751e-12 1.65004968079667 2.02041689804487e-26 MirTarget -0.20565646608886 5.5779942589556e-14 NA NA NA hsa-let-7b-5p PDGFRA 0.770868211539597 6.63408323707647e-21 -3.78993218513957 5.84256232656759e-33 miRNAWalker2_validate -0.744189949569241 0.000853482541380744 NA NA NA hsa-miR-106b-5p PDGFRA 1.07509411417907 2.11739194181878e-36 -3.78993218513957 5.84256232656759e-33 MirTarget;miRNATAP -1.52699938391706 7.64844256452476e-15 NA NA NA hsa-miR-130b-3p PDGFRA 1.12788913578446 2.939369462276e-16 -3.78993218513957 5.84256232656759e-33 MirTarget;miRNATAP -0.367163537880206 0.00634739389951908 NA NA NA hsa-miR-142-5p PDGFRA 1.88417391525707 1.2096808039882e-27 -3.78993218513957 5.84256232656759e-33 PITA;mirMAP;miRNATAP -0.473816152387234 3.28987725776332e-06 NA NA NA hsa-miR-16-1-3p PDGFRA 1.51429140700091 3.17219833254498e-37 -3.78993218513957 5.84256232656759e-33 MirTarget -0.936133152915647 8.28916380630762e-11 NA NA NA hsa-miR-17-5p PDGFRA 0.494260110870015 3.8348005261e-09 -3.78993218513957 5.84256232656759e-33 MirTarget;TargetScan;miRNATAP -1.12023059618189 6.47834222552057e-07 NA NA NA hsa-miR-181a-5p PDGFRA 1.11111114875339 3.97880443756442e-29 -3.78993218513957 5.84256232656759e-33 MirTarget;miRNATAP -1.13167968181832 1.00578978735371e-10 NA NA NA hsa-miR-181b-5p PDGFRA 1.49054296272357 3.69051660739368e-41 -3.78993218513957 5.84256232656759e-33 MirTarget;miRNATAP -1.0831393363512 3.58334758184159e-13 NA NA NA hsa-miR-186-5p PDGFRA 0.507217561043443 9.04455748270995e-10 -3.78993218513957 5.84256232656759e-33 MirTarget -0.76722366281197 0.00085346453663738 NA NA NA hsa-miR-193a-3p PDGFRA 0.849206638484406 3.68101781083335e-14 -3.78993218513957 5.84256232656759e-33 miRanda -0.670433703095133 5.33609287809933e-05 NA NA NA hsa-miR-196a-5p PDGFRA 0.440858887700369 2.0077143292463e-05 -3.78993218513957 5.84256232656759e-33 MirTarget;miRNATAP -0.807966664131365 1.24871502376204e-05 NA NA NA hsa-miR-20a-5p PDGFRA 0.702602695798242 4.06372887613329e-13 -3.78993218513957 5.84256232656759e-33 MirTarget;miRNATAP -1.0995133850917 7.76850607822403e-09 NA NA NA hsa-miR-224-5p PDGFRA 2.84654230414912 3.0480927226395e-47 -3.78993218513957 5.84256232656759e-33 MirTarget -0.560824939024689 9.29216493461181e-12 NA NA NA hsa-miR-27a-3p PDGFRA 0.558934437526245 1.44256383086177e-12 -3.78993218513957 5.84256232656759e-33 MirTarget;miRNATAP -0.88742400202454 0.000202616724972923 NA NA NA hsa-miR-28-5p PDGFRA 0.461962042257226 3.32424690573327e-11 -3.78993218513957 5.84256232656759e-33 miRanda -0.92447717530526 0.000728496310352206 NA NA NA hsa-miR-330-5p PDGFRA 1.44960468659754 2.12131210588035e-45 -3.78993218513957 5.84256232656759e-33 miRanda -0.905908236362134 2.16923297258051e-08 NA NA NA hsa-miR-338-3p PDGFRA 0.906250377628867 2.76970900371139e-15 -3.78993218513957 5.84256232656759e-33 miRanda -0.637819265775912 7.72917116687921e-05 NA NA NA hsa-miR-338-5p PDGFRA 0.628429807914222 1.27575140717947e-06 -3.78993218513957 5.84256232656759e-33 mirMAP;miRNATAP -0.450795738987696 0.00269083695175716 NA NA NA hsa-miR-342-3p PDGFRA 1.4124432570595 1.07208971556131e-28 -3.78993218513957 5.84256232656759e-33 MirTarget;miRanda;miRNATAP -0.694461078438614 4.90067077355219e-07 NA NA NA hsa-miR-34a-5p PDGFRA 1.07544567720768 1.81510842038009e-20 -3.78993218513957 5.84256232656759e-33 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.873046587006104 1.72995840633287e-08 22750848 Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network glioblastoma hsa-miR-374a-5p PDGFRA 0.543061152108237 2.19403097299769e-14 -3.78993218513957 5.84256232656759e-33 mirMAP -0.874227666145286 0.000973487956615665 NA NA NA hsa-miR-454-3p PDGFRA 0.68285296887698 1.17407812677787e-08 -3.78993218513957 5.84256232656759e-33 MirTarget;miRNATAP -0.564425512169116 0.00036544900032461 NA NA NA hsa-miR-455-5p PDGFRA 0.773674551205946 2.12957541541474e-09 -3.78993218513957 5.84256232656759e-33 MirTarget;PITA;miRanda -0.947080211002297 3.30515111107968e-11 NA NA NA hsa-miR-542-3p PDGFRA 0.431147917094433 0.000254981247606435 -3.78993218513957 5.84256232656759e-33 miRanda -0.442130370438674 0.00699356752210394 NA NA NA hsa-miR-576-5p PDGFRA 1.06681109513983 5.69294424466526e-24 -3.78993218513957 5.84256232656759e-33 mirMAP -1.09144002614137 6.09402828933535e-11 NA NA NA hsa-miR-590-3p PDGFRA 1.13702599385212 3.53435739887793e-22 -3.78993218513957 5.84256232656759e-33 miRanda;mirMAP -0.970020105353422 1.43465903827534e-10 NA NA NA hsa-miR-590-5p PDGFRA 0.709763558412506 1.11883921359361e-11 -3.78993218513957 5.84256232656759e-33 miRanda -0.805041348062301 6.78234301048255e-06 NA NA NA hsa-miR-616-5p PDGFRA 0.913426384742148 3.78418389333709e-09 -3.78993218513957 5.84256232656759e-33 mirMAP -0.558608482543338 5.68208963722558e-06 NA NA NA hsa-miR-7-1-3p PDGFRA 0.544601828025304 5.33830451326047e-07 -3.78993218513957 5.84256232656759e-33 mirMAP -0.741792492104915 2.27057862094563e-05 NA NA NA hsa-miR-93-5p PDGFRA 1.37365940377595 2.37567548683245e-46 -3.78993218513957 5.84256232656759e-33 MirTarget;miRNATAP -1.44923917304051 3.40005219888479e-18 NA NA NA hsa-miR-29a-3p PDGFRB -0.431613225927952 4.10166815070288e-08 0.733059789264273 9.08256836273142e-08 miRNATAP -0.452409180680295 2.53894645761997e-06 NA NA NA hsa-miR-29b-3p PDGFRB -0.228125979913806 0.0271621721891603 0.733059789264273 9.08256836273142e-08 miRNATAP -0.473479216745421 9.29300376624436e-11 NA NA NA hsa-miR-29c-3p PDGFRB -0.238671318446745 0.0141475322347596 0.733059789264273 9.08256836273142e-08 miRNATAP -0.358531848837518 5.48317704341144e-06 NA NA NA hsa-miR-664a-3p PDGFRB -0.019312777079624 0.825861598748857 0.733059789264273 9.08256836273142e-08 MirTarget -0.347941365487638 8.25629516369049e-05 NA NA NA hsa-miR-149-5p PGF -1.95790336710741 8.46371715052367e-27 3.69738936393984 3.63417715211415e-41 miRNATAP -0.434144787619864 4.54062927450752e-07 NA NA NA hsa-miR-199b-5p PGF -2.39483476763681 1.04659509514884e-17 3.69738936393984 3.63417715211415e-41 miRanda -0.224137431584973 0.000173766273357621 NA NA NA hsa-miR-335-5p PGF -2.09515619961552 1.03765771499548e-25 3.69738936393984 3.63417715211415e-41 miRNATAP -0.515140827192959 5.43702586061577e-11 NA NA NA hsa-miR-429 PGF -2.16569233119434 2.66862243626443e-37 3.69738936393984 3.63417715211415e-41 miRNATAP -0.773105088772864 1.94034273033144e-19 NA NA NA hsa-miR-766-3p PGF -0.230617949950715 0.0566289375252083 3.69738936393984 3.63417715211415e-41 MirTarget -0.376787325836558 0.00862438364612218 NA NA NA hsa-let-7f-1-3p PIK3CA 0.477913872379336 4.46669616865068e-05 -0.342309377518198 0.000115361959187206 mirMAP -0.117169302105272 0.00980511224865979 NA NA NA hsa-miR-148a-5p PIK3CA 0.415500302855613 0.000691460831436767 -0.342309377518198 0.000115361959187206 mirMAP -0.127137756769153 0.00150846590255829 NA NA NA hsa-miR-320b PIK3CA 0.300497419754843 0.0245219177384172 -0.342309377518198 0.000115361959187206 miRanda -0.109684919459557 0.00295331979925903 NA NA NA hsa-miR-339-5p PIK3CA 0.322848334531193 0.0117281778821612 -0.342309377518198 0.000115361959187206 miRanda -0.156390103299638 4.31357238138231e-05 NA NA NA hsa-miR-590-3p PIK3CA 1.13702599385212 3.53435739887793e-22 -0.342309377518198 0.000115361959187206 miRanda;mirMAP -0.167970910292111 1.76355187639927e-05 NA NA NA hsa-miR-590-5p PIK3CA 0.709763558412506 1.11883921359361e-11 -0.342309377518198 0.000115361959187206 miRanda -0.179027916238388 8.77558290901021e-05 NA NA NA hsa-miR-130b-3p PIK3CB 1.12788913578446 2.939369462276e-16 -0.247995112719303 0.00148503458375338 miRNATAP -0.166034631736904 1.58184303321712e-08 NA NA NA hsa-miR-19a-3p PIK3CB 0.722913586880779 2.76301458932381e-10 -0.247995112719303 0.00148503458375338 miRNATAP -0.138948641019506 0.000146950619817948 NA NA NA hsa-miR-19b-3p PIK3CB 0.195940928879427 0.0300512922542325 -0.247995112719303 0.00148503458375338 miRNATAP -0.155249167038679 0.00123255333914152 NA NA NA hsa-miR-25-3p PIK3CB 1.12016166564779 3.79069348635778e-48 -0.247995112719303 0.00148503458375338 miRNATAP -0.168848015389201 0.000511445370430535 NA NA NA hsa-miR-590-3p PIK3CB 1.13702599385212 3.53435739887793e-22 -0.247995112719303 0.00148503458375338 miRNATAP -0.152204162601648 8.6055969781532e-06 NA NA NA hsa-miR-92b-3p PIK3CB 0.418630595140165 6.50466149211154e-05 -0.247995112719303 0.00148503458375338 miRNATAP -0.132204554754912 0.00123182058684873 NA NA NA hsa-miR-10b-5p PIK3CD -0.89971464210447 1.18190532299934e-20 0.827862115800704 6.93199253004924e-19 miRNAWalker2_validate -0.322882758324939 5.32986923354336e-10 NA NA NA hsa-miR-1468-5p PIK3CD -0.311126383179539 0.00979113361106863 0.827862115800704 6.93199253004924e-19 MirTarget -0.200155097962759 8.08016260976088e-06 NA NA NA hsa-miR-30a-5p PIK3CD -0.778411951775343 2.73322451127932e-16 0.827862115800704 6.93199253004924e-19 miRNAWalker2_validate;MirTarget;miRNATAP -0.206007694378125 0.000161176631172019 23486085 miR 30a suppresses cell migration and invasion through downregulation of PIK3CD in colorectal carcinoma; A luciferase reporter assay was performed to determine target association between miR-30a and phosphoinositide 3-kinase catalytic subunit delta PIK3CD miR-30a was significantly downregulated in highly metastatic CRC cell lines and metastatic tissues; Further studies revealed that PIK3CD is a direct target of miR-30a as miR-30a bounds directly to the 3'-UTR of PIK3CD subsequently reducing its expression; Similar to the restoring miR-30a expression PIK3CD downregulation inhibited cell migration and invasion whereas PIK3CD overexpression rescued the suppressive effect of miR-30a; Moreover significant downregulation of miR-30a in metastatic CRC tissues was found to be inversely correlated with PIK3CD expression; Mechanistic studies revealed that miR-30a down-regulated the expression of key components of the Akt/mTOR pathway whereas PIK3CD overexpression reversed this negative effect cell migration colorectal cancer hsa-miR-30b-3p PIK3CD -1.64703050862226 1.89878531036464e-31 0.827862115800704 6.93199253004924e-19 MirTarget -0.256459682857462 3.84122966933957e-14 NA NA NA hsa-miR-30b-5p PIK3CD -1.18330589477119 6.8341618466966e-27 0.827862115800704 6.93199253004924e-19 MirTarget -0.212463225121162 2.43792629370427e-06 NA NA NA hsa-miR-30c-5p PIK3CD -1.08783070774238 2.02505402525786e-24 0.827862115800704 6.93199253004924e-19 MirTarget;miRNATAP -0.191697315876392 4.85249073283528e-05 NA NA NA hsa-miR-30d-5p PIK3CD -0.202727675788184 0.00659067084745794 0.827862115800704 6.93199253004924e-19 MirTarget;miRNATAP -0.209303428523125 0.00450077920142443 NA NA NA hsa-miR-106b-5p PIK3R1 1.07509411417907 2.11739194181878e-36 -0.234314125271815 0.0111750886765385 MirTarget;miRNATAP -0.179369079303185 0.000816789511004284 NA NA NA hsa-miR-221-3p PIK3R1 0.337895669520713 0.0136448974691037 -0.234314125271815 0.0111750886765385 MirTarget -0.163462882563838 9.21701112965761e-06 NA NA NA hsa-miR-222-3p PIK3R1 0.214811008033524 0.0965295551752457 -0.234314125271815 0.0111750886765385 MirTarget -0.107248741245045 0.00671314109485487 NA NA NA hsa-miR-590-3p PIK3R1 1.13702599385212 3.53435739887793e-22 -0.234314125271815 0.0111750886765385 miRanda;mirMAP -0.106905404095112 0.00880343764678398 NA NA NA hsa-miR-182-5p PIK3R3 -0.608710746044567 0.0025264935278104 0.439819702071113 8.25824839758606e-05 mirMAP -0.153374534942348 3.96734579923425e-07 NA NA NA hsa-miR-339-5p PIK3R3 0.322848334531193 0.0117281778821612 0.439819702071113 8.25824839758606e-05 MirTarget;miRanda -0.192609585710903 6.48743953207512e-05 NA NA NA hsa-miR-365a-3p PIK3R3 0.80809616164259 2.36039522526e-12 0.439819702071113 8.25824839758606e-05 MirTarget -0.16533292375838 0.00153486106521956 NA NA NA hsa-miR-96-5p PIK3R3 -1.00223771166604 3.91564621567028e-06 0.439819702071113 8.25824839758606e-05 mirMAP -0.164731670984697 7.78245878052581e-09 NA NA NA hsa-miR-106b-5p PLA2G12A 1.07509411417907 2.11739194181878e-36 -0.398969072863746 5.55717944273617e-08 mirMAP -0.318990060549306 2.29217198651414e-14 NA NA NA hsa-miR-140-5p PLA2G12A 0.504309496243674 3.09884038729031e-11 -0.398969072863746 5.55717944273617e-08 miRanda -0.188599257543893 0.000382484546134811 NA NA NA hsa-miR-142-5p PLA2G12A 1.88417391525707 1.2096808039882e-27 -0.398969072863746 5.55717944273617e-08 mirMAP -0.138073144669251 9.04790839331805e-11 NA NA NA hsa-miR-150-5p PLA2G12A 1.00371863159681 1.09871676395528e-09 -0.398969072863746 5.55717944273617e-08 mirMAP -0.14806285256437 5.07167045463163e-10 NA NA NA hsa-miR-16-2-3p PLA2G12A 1.3046118743965 4.17207934608428e-19 -0.398969072863746 5.55717944273617e-08 mirMAP -0.111423414392617 2.54085038058137e-05 NA NA NA hsa-miR-17-3p PLA2G12A 0.723795600017259 5.90151677164931e-18 -0.398969072863746 5.55717944273617e-08 mirMAP -0.246147322379887 1.06111832675154e-07 NA NA NA hsa-miR-17-5p PLA2G12A 0.494260110870015 3.8348005261e-09 -0.398969072863746 5.55717944273617e-08 mirMAP -0.172159927457143 0.000360024830260926 NA NA NA hsa-miR-181a-5p PLA2G12A 1.11111114875339 3.97880443756442e-29 -0.398969072863746 5.55717944273617e-08 mirMAP -0.208596329981168 2.61179244938667e-08 NA NA NA hsa-miR-181b-5p PLA2G12A 1.49054296272357 3.69051660739368e-41 -0.398969072863746 5.55717944273617e-08 mirMAP -0.191772279611356 2.18947515885896e-09 NA NA NA hsa-miR-181c-5p PLA2G12A 0.762784646696248 4.48373118147729e-10 -0.398969072863746 5.55717944273617e-08 mirMAP -0.120873469964364 0.0002220646158873 NA NA NA hsa-miR-186-5p PLA2G12A 0.507217561043443 9.04455748270995e-10 -0.398969072863746 5.55717944273617e-08 mirMAP -0.167023490324012 0.00062699328283718 NA NA NA hsa-miR-20a-5p PLA2G12A 0.702602695798242 4.06372887613329e-13 -0.398969072863746 5.55717944273617e-08 mirMAP -0.131580419112628 0.00139337128447633 NA NA NA hsa-miR-330-3p PLA2G12A 0.912906550436308 3.35037014057665e-13 -0.398969072863746 5.55717944273617e-08 miRNATAP -0.145697955190855 5.6577432220273e-06 NA NA NA hsa-miR-374a-3p PLA2G12A 1.13863935833993 2.79089304015401e-44 -0.398969072863746 5.55717944273617e-08 mirMAP -0.14651878955133 0.000919658365223926 NA NA NA hsa-miR-590-3p PLA2G12A 1.13702599385212 3.53435739887793e-22 -0.398969072863746 5.55717944273617e-08 PITA;miRanda;miRNATAP -0.144365381787861 9.87289711374494e-06 NA NA NA hsa-miR-625-3p PLA2G12A 1.09679549288964 4.60800634006165e-20 -0.398969072863746 5.55717944273617e-08 mirMAP -0.225068546092664 8.61375480674311e-13 NA NA NA hsa-miR-92b-3p PLA2G12A 0.418630595140165 6.50466149211154e-05 -0.398969072863746 5.55717944273617e-08 miRNAWalker2_validate -0.195561990632176 4.06793360999897e-07 NA NA NA hsa-miR-93-5p PLA2G12A 1.37365940377595 2.37567548683245e-46 -0.398969072863746 5.55717944273617e-08 mirMAP -0.163143512838149 9.92914696804009e-06 NA NA NA hsa-miR-30c-2-3p PLA2G2D -1.28402709024345 6.77577627955178e-25 3.25786426267112 1.63883282978629e-21 mirMAP -1.4911913745295 5.06954471302161e-27 NA NA NA hsa-miR-1301-3p PLA2G4A 0.393537638993954 0.000390498879474539 -1.85529407773687 1.9717892081168e-32 MirTarget -0.276077994739491 0.00127728289438848 NA NA NA hsa-miR-142-3p PLA2G4A 1.88928758773299 2.72985643829893e-22 -1.85529407773687 1.9717892081168e-32 miRanda -0.176304107715065 0.000110262875817659 NA NA NA hsa-miR-144-3p PLA2G4A 1.4617706700291 9.18139413836375e-11 -1.85529407773687 1.9717892081168e-32 MirTarget -0.132461250631428 0.00125728302023368 NA NA NA hsa-miR-146b-5p PLA2G4A 1.40714170253819 2.9559871816487e-12 -1.85529407773687 1.9717892081168e-32 miRNAWalker2_validate -0.158304464185306 0.000517342945920931 NA NA NA hsa-miR-181a-5p PLA2G4A 1.11111114875339 3.97880443756442e-29 -1.85529407773687 1.9717892081168e-32 MirTarget -0.547914249646334 2.17897779368898e-10 NA NA NA hsa-miR-181b-5p PLA2G4A 1.49054296272357 3.69051660739368e-41 -1.85529407773687 1.9717892081168e-32 MirTarget -0.580974807139508 1.44687429049341e-15 NA NA NA hsa-miR-181d-5p PLA2G4A 1.00720380524132 6.04219503683814e-14 -1.85529407773687 1.9717892081168e-32 MirTarget -0.188540383634248 0.00595973754453785 NA NA NA hsa-miR-361-5p PLA2G4A 0.0514169367202078 0.382929376393199 -1.85529407773687 1.9717892081168e-32 miRanda -0.504250919786896 0.00245854577917651 NA NA NA hsa-miR-374a-5p PLA2G4A 0.543061152108237 2.19403097299769e-14 -1.85529407773687 1.9717892081168e-32 mirMAP -0.477322231169729 0.000249501916746624 NA NA NA hsa-miR-374b-5p PLA2G4A 0.0804104684417872 0.365593963035077 -1.85529407773687 1.9717892081168e-32 mirMAP -0.293947726971175 0.006867825439803 NA NA NA hsa-miR-590-3p PLA2G4A 1.13702599385212 3.53435739887793e-22 -1.85529407773687 1.9717892081168e-32 miRanda -0.489193495036296 4.85569925069997e-11 NA NA NA hsa-miR-125a-5p PLA2G4D -0.561874059994802 7.3931856356891e-13 2.18726872824291 4.8509673091129e-12 miRanda -1.42183240313145 8.92884268267104e-11 NA NA NA hsa-miR-615-3p PLA2G4D -0.777370544471479 2.08193713560545e-08 2.18726872824291 4.8509673091129e-12 miRanda -0.353781333211389 0.00562149254732312 NA NA NA hsa-miR-331-3p PLA2G4F 0.431607034018882 6.83022920590941e-05 -8.85050131418945 2.79353675193781e-72 miRNAWalker2_validate -1.22651680522403 7.91078440814889e-05 NA NA NA hsa-miR-455-5p PLA2G4F 0.773674551205946 2.12957541541474e-09 -8.85050131418945 2.79353675193781e-72 miRanda -2.0522585934831 6.92320559752333e-17 NA NA NA hsa-miR-92a-3p PLA2G4F 0.178194888895831 0.0088835082650834 -8.85050131418945 2.79353675193781e-72 miRNAWalker2_validate -2.23900272109896 8.50559952953754e-06 NA NA NA hsa-miR-125a-5p PLA2G5 -0.561874059994802 7.3931856356891e-13 2.9004312005942 1.2325420826324e-27 miRanda -1.07156821996216 4.64642714926677e-08 NA NA NA hsa-miR-429 PLA2G5 -2.16569233119434 2.66862243626443e-37 2.9004312005942 1.2325420826324e-27 miRanda -0.668499359545984 7.01186997138673e-17 NA NA NA hsa-miR-324-5p PLA2G6 -0.487750893426456 3.74472736457965e-05 0.682316411790433 7.33596322664269e-06 miRanda -0.282227835071844 6.91880555505667e-05 NA NA NA hsa-miR-455-5p PLCE1 0.773674551205946 2.12957541541474e-09 -0.755052615485343 2.19722223291114e-05 miRanda -0.296848778951874 7.01722430948256e-05 NA NA NA hsa-miR-532-5p PLCE1 -1.09700348358668 8.34836230254408e-26 -0.755052615485343 2.19722223291114e-05 miRNATAP -0.239028046492355 0.00674193659159705 NA NA NA hsa-miR-125a-5p PLCG1 -0.561874059994802 7.3931856356891e-13 0.609751089662416 1.12377014694825e-19 miRanda -0.13045375090493 0.00755064517220051 NA NA NA hsa-miR-200b-3p PLCG1 -1.70383252137161 2.38979336321755e-30 0.609751089662416 1.12377014694825e-19 TargetScan -0.175885910448865 2.49250011897743e-14 NA NA NA hsa-miR-30a-5p PLCG1 -0.778411951775343 2.73322451127932e-16 0.609751089662416 1.12377014694825e-19 miRNATAP -0.26342973516773 6.65372044643881e-12 NA NA NA hsa-miR-30c-5p PLCG1 -1.08783070774238 2.02505402525786e-24 0.609751089662416 1.12377014694825e-19 miRNATAP -0.22208425619646 2.5275061108132e-11 NA NA NA hsa-miR-362-3p PLCG1 -0.753214251798232 3.0025661608035e-07 0.609751089662416 1.12377014694825e-19 miRanda -0.109722570107135 4.44813555671034e-05 NA NA NA hsa-miR-429 PLCG1 -2.16569233119434 2.66862243626443e-37 0.609751089662416 1.12377014694825e-19 PITA;miRanda;miRNATAP -0.150507552347676 2.69336121445354e-14 NA NA NA hsa-miR-590-3p PLCG2 1.13702599385212 3.53435739887793e-22 -1.65354046944029 1.01289171976521e-32 miRanda -0.459695253589225 2.75512006566686e-12 NA NA NA hsa-miR-182-5p PLD1 -0.608710746044567 0.0025264935278104 0.455999662224987 6.99859154369231e-06 MirTarget;miRNATAP -0.19086656611272 1.76220268462972e-12 NA NA NA hsa-miR-183-5p PLD1 -1.21596931064487 1.31473205758898e-08 0.455999662224987 6.99859154369231e-06 mirMAP -0.179895641590124 6.36914820958763e-13 NA NA NA hsa-miR-203a-3p PLD1 -2.25533513338731 1.77332845294014e-21 0.455999662224987 6.99859154369231e-06 MirTarget -0.107849019525807 1.0379840086848e-06 NA NA NA hsa-miR-335-3p PLD1 -1.36498175550207 6.84287752180534e-13 0.455999662224987 6.99859154369231e-06 mirMAP -0.107608191394001 0.000170398262630073 NA NA NA hsa-miR-500a-5p PLD1 -1.28374735824553 1.95870374809798e-20 0.455999662224987 6.99859154369231e-06 MirTarget -0.1110702964608 0.00394282030978698 NA NA NA hsa-miR-664a-3p PLD1 -0.019312777079624 0.825861598748857 0.455999662224987 6.99859154369231e-06 mirMAP -0.211295105603786 0.00118255032584751 NA NA NA hsa-miR-96-5p PLD1 -1.00223771166604 3.91564621567028e-06 0.455999662224987 6.99859154369231e-06 miRNATAP -0.183572052235455 8.2819022833811e-13 NA NA NA hsa-miR-203a-3p PLD2 -2.25533513338731 1.77332845294014e-21 0.759138875231499 1.57881038192283e-22 MirTarget -0.106284783692392 1.93325440241131e-09 24270883 The transfection of the miR-203 mimic into U251 cells markedly downregulated the expression of phospholipase D2 PLD2 which was identified as a direct target of miR-203; Furthermore miR-203 overexpression significantly suppressed the proliferation and invasion of U251 cells while the overexpression of PLD2 abrogated these effects induced by the miR-203 mimic; In conclusion the present study demonstrated the clinical significance of miR-203 in gliomas and suggested that miR-203 was able to inhibit the proliferation and invasion of glioma cells partially at least via suppressing the protein expression of PLD2 glioblastoma hsa-miR-429 PLD2 -2.16569233119434 2.66862243626443e-37 0.759138875231499 1.57881038192283e-22 miRNATAP -0.152131690146072 7.94328302910362e-11 NA NA NA hsa-miR-16-2-3p PRKACB 1.3046118743965 4.17207934608428e-19 -0.68047992720199 6.2289588419962e-18 mirMAP -0.110421791682537 0.000180893091391508 NA NA NA hsa-miR-17-5p PRKACB 0.494260110870015 3.8348005261e-09 -0.68047992720199 6.2289588419962e-18 TargetScan -0.177111212378275 0.000974492661946987 NA NA NA hsa-miR-18a-5p PRKACB 0.936704393213466 1.05064580570579e-10 -0.68047992720199 6.2289588419962e-18 miRNATAP -0.129810473204045 2.02983188773094e-05 NA NA NA hsa-miR-193a-3p PRKACB 0.849206638484406 3.68101781083335e-14 -0.68047992720199 6.2289588419962e-18 miRanda -0.152325629995289 0.000102213273809685 NA NA NA hsa-miR-19a-3p PRKACB 0.722913586880779 2.76301458932381e-10 -0.68047992720199 6.2289588419962e-18 MirTarget;miRNATAP -0.149521467816826 0.000117450056574833 NA NA NA hsa-miR-19b-3p PRKACB 0.195940928879427 0.0300512922542325 -0.68047992720199 6.2289588419962e-18 miRNAWalker2_validate;MirTarget;miRNATAP -0.151382160966433 0.0030186219386488 NA NA NA hsa-miR-34a-5p PRKACB 1.07544567720768 1.81510842038009e-20 -0.68047992720199 6.2289588419962e-18 miRNATAP -0.155553394908043 2.5599855449644e-05 NA NA NA hsa-miR-590-3p PRKACB 1.13702599385212 3.53435739887793e-22 -0.68047992720199 6.2289588419962e-18 MirTarget;PITA;miRanda;miRNATAP -0.170298039845818 2.59547529658115e-06 NA NA NA hsa-miR-590-5p PRKACB 0.709763558412506 1.11883921359361e-11 -0.68047992720199 6.2289588419962e-18 miRanda -0.122511813057726 0.00404292608644287 NA NA NA hsa-miR-93-5p PRKACB 1.37365940377595 2.37567548683245e-46 -0.68047992720199 6.2289588419962e-18 miRNAWalker2_validate -0.230489200796702 1.41605310708363e-08 NA NA NA hsa-miR-142-5p PRKCA 1.88417391525707 1.2096808039882e-27 -1.40949595564765 3.30510040485645e-31 mirMAP -0.203326926537334 1.32429030012509e-07 NA NA NA hsa-miR-146a-5p PRKCA 1.04938133739924 7.51013231709992e-12 -1.40949595564765 3.30510040485645e-31 mirMAP -0.138636449569245 0.00290151925750071 NA NA NA hsa-miR-150-5p PRKCA 1.00371863159681 1.09871676395528e-09 -1.40949595564765 3.30510040485645e-31 mirMAP -0.141463696474327 0.00116284963615584 NA NA NA hsa-miR-17-3p PRKCA 0.723795600017259 5.90151677164931e-18 -1.40949595564765 3.30510040485645e-31 miRNAWalker2_validate -0.55301268177802 1.37146521298911e-11 NA NA NA hsa-miR-181a-5p PRKCA 1.11111114875339 3.97880443756442e-29 -1.40949595564765 3.30510040485645e-31 mirMAP -0.540264161188695 1.18526956498458e-16 NA NA NA hsa-miR-181b-5p PRKCA 1.49054296272357 3.69051660739368e-41 -1.40949595564765 3.30510040485645e-31 mirMAP -0.473733908349652 2.1676855775351e-17 NA NA NA hsa-miR-181c-5p PRKCA 0.762784646696248 4.48373118147729e-10 -1.40949595564765 3.30510040485645e-31 mirMAP -0.256287812602341 1.11910895047438e-05 NA NA NA hsa-miR-186-5p PRKCA 0.507217561043443 9.04455748270995e-10 -1.40949595564765 3.30510040485645e-31 miRNATAP -0.239864584666343 0.00624473839846306 NA NA NA hsa-miR-19b-1-5p PRKCA 0.66692013055553 1.55789130176287e-09 -1.40949595564765 3.30510040485645e-31 mirMAP -0.193605809138291 0.00310670883960429 NA NA NA hsa-miR-224-5p PRKCA 2.84654230414912 3.0480927226395e-47 -1.40949595564765 3.30510040485645e-31 mirMAP -0.224468346181721 5.75169704731423e-13 NA NA NA hsa-miR-2355-3p PRKCA 1.32757890426926 1.88016636795886e-18 -1.40949595564765 3.30510040485645e-31 mirMAP -0.261610517007587 1.83229270594567e-08 NA NA NA hsa-miR-3170 PRKCA 0.664452094631118 2.78926402033808e-05 -1.40949595564765 3.30510040485645e-31 mirMAP -0.143525555001005 0.00205070350789402 NA NA NA hsa-miR-330-3p PRKCA 0.912906550436308 3.35037014057665e-13 -1.40949595564765 3.30510040485645e-31 mirMAP -0.261128612369017 5.50369517469821e-06 NA NA NA hsa-miR-340-5p PRKCA 1.14479851941741 2.91936881701444e-15 -1.40949595564765 3.30510040485645e-31 mirMAP -0.258076358061294 7.18198801898922e-08 NA NA NA hsa-miR-374a-3p PRKCA 1.13863935833993 2.79089304015401e-44 -1.40949595564765 3.30510040485645e-31 mirMAP -0.684628765839887 6.42429291388675e-20 NA NA NA hsa-miR-374a-5p PRKCA 0.543061152108237 2.19403097299769e-14 -1.40949595564765 3.30510040485645e-31 mirMAP -0.522893225273422 1.47637062832505e-07 NA NA NA hsa-miR-452-5p PRKCA 2.05325688842141 2.82238393643084e-40 -1.40949595564765 3.30510040485645e-31 mirMAP -0.33224472833984 1.34300342334138e-16 NA NA NA hsa-miR-590-3p PRKCA 1.13702599385212 3.53435739887793e-22 -1.40949595564765 3.30510040485645e-31 PITA;miRanda;mirMAP;miRNATAP -0.332392461839564 9.25847276505916e-09 NA NA NA hsa-miR-592 PRKCA 2.6404220268798 8.81369998128794e-32 -1.40949595564765 3.30510040485645e-31 miRNATAP -0.172568846986646 3.52884206079864e-09 NA NA NA hsa-miR-200b-3p PRKCB -1.70383252137161 2.38979336321755e-30 0.583904117599654 0.000239395825023428 MirTarget -0.161635318424647 0.00276990701776461 NA NA NA hsa-miR-27b-3p PRKCB -0.699527231242518 1.07356023759234e-15 0.583904117599654 0.000239395825023428 MirTarget;miRNATAP -0.381848642069096 8.29210459175488e-05 NA NA NA hsa-miR-30a-3p PRKCB -0.955360819934585 1.97009535429185e-20 0.583904117599654 0.000239395825023428 mirMAP -0.27445649163855 0.000675651397734009 NA NA NA hsa-miR-30b-5p PRKCB -1.18330589477119 6.8341618466966e-27 0.583904117599654 0.000239395825023428 mirMAP -0.43302228945984 2.35087485736611e-09 NA NA NA hsa-miR-30c-5p PRKCB -1.08783070774238 2.02505402525786e-24 0.583904117599654 0.000239395825023428 mirMAP -0.200266218821399 0.00954411836448046 NA NA NA hsa-miR-30d-3p PRKCB -0.249777194282131 0.00235356711813496 0.583904117599654 0.000239395825023428 mirMAP -0.527711285390385 8.06872957758744e-07 NA NA NA hsa-miR-30d-5p PRKCB -0.202727675788184 0.00659067084745794 0.583904117599654 0.000239395825023428 mirMAP -0.615678537820375 1.81242737170691e-07 NA NA NA hsa-miR-361-5p PRKCB 0.0514169367202078 0.382929376393199 0.583904117599654 0.000239395825023428 MirTarget;miRanda;miRNATAP -0.499291115851109 0.00117224790143438 NA NA NA hsa-miR-429 PRKCB -2.16569233119434 2.66862243626443e-37 0.583904117599654 0.000239395825023428 MirTarget;miRanda;miRNATAP -0.192274100704377 2.89126645159923e-05 NA NA NA hsa-let-7a-3p PTPN11 0.0677487960013088 0.460458477653989 -0.341712742609257 1.33147607483599e-07 mirMAP -0.165904915410155 2.81371142679823e-05 NA NA NA hsa-miR-181a-5p PTPN11 1.11111114875339 3.97880443756442e-29 -0.341712742609257 1.33147607483599e-07 miRNAWalker2_validate;miRTarBase -0.141525373268749 2.14767082806646e-05 NA NA NA hsa-miR-19b-3p PTPN11 0.195940928879427 0.0300512922542325 -0.341712742609257 1.33147607483599e-07 mirMAP -0.132361233509163 0.00103786554162883 NA NA NA hsa-miR-28-5p PTPN11 0.461962042257226 3.32424690573327e-11 -0.341712742609257 1.33147607483599e-07 miRanda -0.201474606930361 7.74069832521273e-05 NA NA NA hsa-miR-320a PTPN11 0.412740558379182 2.02929519701706e-05 -0.341712742609257 1.33147607483599e-07 miRNAWalker2_validate;mirMAP -0.116787905747509 0.00169734274185247 NA NA NA hsa-miR-374b-5p PTPN11 0.0804104684417872 0.365593963035077 -0.341712742609257 1.33147607483599e-07 mirMAP -0.121011924905068 0.00332584176997666 NA NA NA hsa-miR-455-5p PTPN11 0.773674551205946 2.12957541541474e-09 -0.341712742609257 1.33147607483599e-07 miRanda -0.153745537425232 1.12242619416936e-08 NA NA NA hsa-miR-101-3p RAB5A 0.683973909682285 2.88573524246948e-15 -0.538826339828201 1.89033136225061e-21 miRNAWalker2_validate;miRTarBase;MirTarget -0.192576051103872 1.22051915660842e-07 24788845 Downregulation of miR 101 3p by hepatitis B virus promotes proliferation and migration of hepatocellular carcinoma cells by targeting Rab5a; Moreover we identified Rab5a was one of the target genes of miR-101-3p in HBV-related HCC; Forced expression of miR-101-3p in liver cell lines resulted in a marked reduction of the expression of Rab5a at both the mRNA and protein level by directly targeting the 3'untranslated region of Rab5a; Overexpression of Rab5a resulted in a reversal of the suppression of proliferation and migration of SMMC-7721 cells mediated by miR-101-3p; Taken together our data show that HBV can downregulate miR-101-3p expression by inhibiting its promoter activity and that downregulation of miR-101-3p promotes HCC cell proliferation and migration by targeting Rab5a liver cancer hsa-miR-130b-3p RAB5A 1.12788913578446 2.939369462276e-16 -0.538826339828201 1.89033136225061e-21 miRNAWalker2_validate;MirTarget;miRNATAP -0.138680991064241 6.8947297558713e-10 NA NA NA hsa-miR-140-5p RAB5A 0.504309496243674 3.09884038729031e-11 -0.538826339828201 1.89033136225061e-21 miRanda -0.185392860312256 1.32446753110561e-05 NA NA NA hsa-miR-18a-5p RAB5A 0.936704393213466 1.05064580570579e-10 -0.538826339828201 1.89033136225061e-21 miRNAWalker2_validate;MirTarget -0.12157842117437 2.67681851870673e-08 NA NA NA hsa-miR-590-3p RAB5A 1.13702599385212 3.53435739887793e-22 -0.538826339828201 1.89033136225061e-21 miRanda;mirMAP -0.148226447757906 1.27238970255776e-08 NA NA NA hsa-miR-106b-5p RAB5B 1.07509411417907 2.11739194181878e-36 -0.377056238317588 5.56850088889396e-30 miRNATAP -0.229223100473723 2.05962595592814e-34 NA NA NA hsa-miR-130b-3p RAB5B 1.12788913578446 2.939369462276e-16 -0.377056238317588 5.56850088889396e-30 miRNAWalker2_validate;miRNATAP -0.102655563154863 5.93150461337884e-15 NA NA NA hsa-miR-17-5p RAB5B 0.494260110870015 3.8348005261e-09 -0.377056238317588 5.56850088889396e-30 miRNAWalker2_validate;TargetScan;miRNATAP -0.143403593200825 2.45064896585698e-10 NA NA NA hsa-miR-19a-3p RAB5B 0.722913586880779 2.76301458932381e-10 -0.377056238317588 5.56850088889396e-30 miRNATAP -0.102104159246529 5.33876439074399e-10 NA NA NA hsa-miR-20a-5p RAB5B 0.702602695798242 4.06372887613329e-13 -0.377056238317588 5.56850088889396e-30 miRNATAP -0.145186159021842 2.3551509311587e-14 NA NA NA hsa-miR-24-3p RAB5B 0.173813044685099 0.00565259443420961 -0.377056238317588 5.56850088889396e-30 miRNATAP -0.157078382383145 6.77204860734986e-07 NA NA NA hsa-miR-330-5p RAB5B 1.44960468659754 2.12131210588035e-45 -0.377056238317588 5.56850088889396e-30 miRNATAP -0.134301355003042 4.67019769234857e-17 NA NA NA hsa-miR-361-3p RAB5B 1.08992546227594 1.13197240706704e-36 -0.377056238317588 5.56850088889396e-30 miRNATAP -0.173290476877386 6.66600214988664e-19 NA NA NA hsa-miR-93-5p RAB5B 1.37365940377595 2.37567548683245e-46 -0.377056238317588 5.56850088889396e-30 miRNAWalker2_validate;miRNATAP -0.177905449912908 3.14267574553726e-27 NA NA NA hsa-miR-155-5p RAB5C 3.26274490570809 5.06841441826518e-51 -0.570127640987095 1.44077774679705e-20 miRNAWalker2_validate;MirTarget -0.100302723858421 1.34817398880956e-13 NA NA NA hsa-miR-186-5p RAB5C 0.507217561043443 9.04455748270995e-10 -0.570127640987095 1.44077774679705e-20 mirMAP -0.122231656533436 0.0041204101806935 NA NA NA hsa-miR-18a-5p RAB5C 0.936704393213466 1.05064580570579e-10 -0.570127640987095 1.44077774679705e-20 MirTarget -0.131983820571681 2.26279095701025e-08 NA NA NA hsa-miR-342-3p RAC3 1.4124432570595 1.07208971556131e-28 -1.40504132869683 4.24492750834751e-13 miRanda -0.303985376974766 0.000136219209735901 NA NA NA hsa-miR-146b-3p RAF1 1.20941495066078 2.12939149602665e-10 -0.729326295365523 1.03493473489106e-42 MirTarget;PITA;miRNATAP -0.126960331865385 9.60010767311038e-15 NA NA NA hsa-miR-15a-5p RAF1 1.42663930007845 1.36006952074963e-57 -0.729326295365523 1.03493473489106e-42 MirTarget;miRNATAP -0.324293625748972 2.12345656575569e-29 NA NA NA hsa-miR-15b-5p RAF1 0.773001494057531 1.71784656078957e-16 -0.729326295365523 1.03493473489106e-42 MirTarget;miRNATAP -0.217283143578276 6.68293363881507e-11 NA NA NA hsa-miR-16-5p RAF1 0.934012514027655 4.85417898318515e-24 -0.729326295365523 1.03493473489106e-42 MirTarget;miRNATAP -0.2832583907681 1.12454604973701e-18 26527888 Besides we identify that Raf1 is a direct target of miR-15a/b miR-16 and miR-195 by dual luciferase reporter assay thyroid cancer hsa-miR-186-5p RAF1 0.507217561043443 9.04455748270995e-10 -0.729326295365523 1.03493473489106e-42 miRNAWalker2_validate -0.248932939680122 1.31766215047697e-10 NA NA NA hsa-miR-195-5p RAF1 0.346502644882604 0.0092562828415903 -0.729326295365523 1.03493473489106e-42 miRTarBase;MirTarget;miRNATAP -0.106749755319653 1.79108008549216e-05 26527888;21350001;27153315;23760062 miR 195 is a key regulator of Raf1 in thyroid cancer; Besides we identify that Raf1 is a direct target of miR-15a/b miR-16 and miR-195 by dual luciferase reporter assay; Furthermore exogenous overexpression of miR-195 significantly inhibits the protein expression of Raf1 and blocks the thyroid cancer cell proliferation;Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer;IGF2BP2 promotes colorectal cancer cell proliferation and survival through interfering with RAF 1 degradation by miR 195; Molecular function analyses revealed that IGF2BP2 regulates RAF1 expression through blocking its degradation by miR-195;Upregulation of miR 195 increases the sensitivity of breast cancer cells to Adriamycin treatment through inhibition of Raf 1; The data showed that miR-195 expression was low in breast cancer cells and multidrug-resistant breast cancer tissues which was associated with reduced Raf-1 expression in vitro and ex vivo; Induction of miR-195 expression promoted tumor cell apoptosis and inhibited breast cancer cell viability but induced the sensitivity of breast cancer cells to Adriamycin treatment and was associated with inhibition of Raf-1 expression in breast cancer cells; Moreover knockdown of Raf-1 expression had similar effects of miR-195 mimics on breast cancer cells both of which were able to suppress Bcl-2 and P-glycoprotein expression in breast cancer cells; The data from the current study demonstrated that expression of miR-195 was inversely associated with Raf-1 expression in breast cancer cell lines and tissue specimens and that Raf-1 is the target gene of miR-195 ;;poor survival; thyroid cancer;breast cancer;colorectal cancer;breast cancer hsa-miR-19a-3p RAF1 0.722913586880779 2.76301458932381e-10 -0.729326295365523 1.03493473489106e-42 MirTarget;miRNATAP -0.154284306170029 3.61502307447547e-08 NA NA NA hsa-miR-19b-3p RAF1 0.195940928879427 0.0300512922542325 -0.729326295365523 1.03493473489106e-42 MirTarget;miRNATAP -0.115125075816159 0.00199179078014951 NA NA NA hsa-miR-331-3p RAF1 0.431607034018882 6.83022920590941e-05 -0.729326295365523 1.03493473489106e-42 MirTarget;miRNATAP -0.158262304030351 1.65741452145876e-07 NA NA NA hsa-miR-484 RAF1 0.571987778099603 9.67278224458421e-10 -0.729326295365523 1.03493473489106e-42 MirTarget -0.240322437451901 1.50205113397331e-12 NA NA NA hsa-miR-497-5p RAF1 0.227757383708836 0.0600073987853074 -0.729326295365523 1.03493473489106e-42 miRTarBase;MirTarget;miRNATAP -0.119677885863477 1.30076085946277e-05 21350001 Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer breast cancer hsa-miR-590-3p RAF1 1.13702599385212 3.53435739887793e-22 -0.729326295365523 1.03493473489106e-42 miRanda -0.179633605652733 4.3114164233555e-12 NA NA NA hsa-miR-93-3p RAF1 0.379664250785728 9.76327751780657e-05 -0.729326295365523 1.03493473489106e-42 miRNATAP -0.192339109650426 1.01632622523622e-08 NA NA NA hsa-miR-942-5p RAF1 0.978672610596303 3.12802933163696e-12 -0.729326295365523 1.03493473489106e-42 MirTarget -0.130737374750736 7.69722175616835e-09 NA NA NA hsa-miR-27b-3p RALA -0.699527231242518 1.07356023759234e-15 0.277392498630737 4.99562013834048e-06 miRNATAP -0.152218726797263 4.01450500030597e-05 NA NA NA hsa-miR-29c-3p RALA -0.238671318446745 0.0141475322347596 0.277392498630737 4.99562013834048e-06 miRNATAP -0.127868011961859 0.000234521128105805 NA NA NA hsa-miR-30a-3p RALA -0.955360819934585 1.97009535429185e-20 0.277392498630737 4.99562013834048e-06 MirTarget;miRNATAP -0.182990831239147 1.54263619071676e-09 NA NA NA hsa-miR-130b-3p RALBP1 1.12788913578446 2.939369462276e-16 -1.35830989223358 4.98717160209672e-59 MirTarget;miRNATAP -0.315340213252041 8.01288316115217e-18 NA NA NA hsa-miR-142-5p RALBP1 1.88417391525707 1.2096808039882e-27 -1.35830989223358 4.98717160209672e-59 PITA;mirMAP -0.295186157270859 1.73373919335703e-27 NA NA NA hsa-miR-143-3p RALBP1 0.544259011512089 1.71102635165867e-05 -1.35830989223358 4.98717160209672e-59 MirTarget -0.143501365158358 0.000952249999687553 NA NA NA hsa-miR-144-3p RALBP1 1.4617706700291 9.18139413836375e-11 -1.35830989223358 4.98717160209672e-59 miRNATAP -0.126605324112891 7.73408095892535e-08 NA NA NA hsa-miR-148b-3p RALBP1 0.346011252093377 4.27203463315056e-06 -1.35830989223358 4.98717160209672e-59 MirTarget -0.324857819969381 9.14494682828219e-06 NA NA NA hsa-miR-186-5p RALBP1 0.507217561043443 9.04455748270995e-10 -1.35830989223358 4.98717160209672e-59 mirMAP -0.309436804288968 2.21365672489989e-06 NA NA NA hsa-miR-19b-1-5p RALBP1 0.66692013055553 1.55789130176287e-09 -1.35830989223358 4.98717160209672e-59 mirMAP -0.204393596662235 3.07372484541427e-05 NA NA NA hsa-miR-301a-3p RALBP1 0.259400847075798 0.0216890736701418 -1.35830989223358 4.98717160209672e-59 MirTarget;miRNATAP -0.142745385709675 0.00380210770780439 NA NA NA hsa-miR-338-3p RALBP1 0.906250377628867 2.76970900371139e-15 -1.35830989223358 4.98717160209672e-59 miRanda;mirMAP -0.257397817807156 1.76515691342801e-08 NA NA NA hsa-miR-340-5p RALBP1 1.14479851941741 2.91936881701444e-15 -1.35830989223358 4.98717160209672e-59 mirMAP -0.257595830721508 3.8716901279848e-13 NA NA NA hsa-miR-378a-3p RALBP1 0.287244802401236 0.0501155019984562 -1.35830989223358 4.98717160209672e-59 mirMAP -0.207974607389394 2.41141774759782e-08 NA NA NA hsa-miR-450b-5p RALBP1 0.404819502355575 0.00357671373841274 -1.35830989223358 4.98717160209672e-59 mirMAP -0.13990427201952 0.000436473158405723 NA NA NA hsa-miR-452-3p RALBP1 1.72039996672257 1.35748079442153e-22 -1.35830989223358 4.98717160209672e-59 MirTarget -0.215097303046385 1.36150895317742e-13 NA NA NA hsa-miR-454-3p RALBP1 0.68285296887698 1.17407812677787e-08 -1.35830989223358 4.98717160209672e-59 MirTarget;miRNATAP -0.253697835774944 1.41142321930777e-08 NA NA NA hsa-miR-542-3p RALBP1 0.431147917094433 0.000254981247606435 -1.35830989223358 4.98717160209672e-59 miRanda -0.230794912817229 6.42461539475321e-07 NA NA NA hsa-miR-590-3p RALBP1 1.13702599385212 3.53435739887793e-22 -1.35830989223358 4.98717160209672e-59 MirTarget;PITA;miRanda;miRNATAP -0.407685355378782 1.19985805719843e-22 NA NA NA hsa-miR-942-5p RALBP1 0.978672610596303 3.12802933163696e-12 -1.35830989223358 4.98717160209672e-59 MirTarget -0.211543158969587 2.03058160048387e-08 NA NA NA hsa-miR-182-5p RALGDS -0.608710746044567 0.0025264935278104 1.09793021618138 3.44535423332662e-31 miRNATAP -0.151805577560124 5.05673453472321e-08 NA NA NA hsa-miR-183-5p RALGDS -1.21596931064487 1.31473205758898e-08 1.09793021618138 3.44535423332662e-31 miRNAWalker2_validate;MirTarget;miRNATAP -0.180331701752858 1.2029085073756e-12 NA NA NA hsa-miR-30b-3p RALGDS -1.64703050862226 1.89878531036464e-31 1.09793021618138 3.44535423332662e-31 MirTarget -0.315857986736098 2.67836356962987e-19 NA NA NA hsa-miR-335-5p RALGDS -2.09515619961552 1.03765771499548e-25 1.09793021618138 3.44535423332662e-31 miRNAWalker2_validate -0.197600247258797 1.75442259156483e-14 NA NA NA hsa-miR-429 RALGDS -2.16569233119434 2.66862243626443e-37 1.09793021618138 3.44535423332662e-31 miRanda -0.204831693303145 2.13484310715988e-12 NA NA NA hsa-miR-615-3p RALGDS -0.777370544471479 2.08193713560545e-08 1.09793021618138 3.44535423332662e-31 miRNAWalker2_validate -0.209420351772332 1.62036445501156e-07 NA NA NA hsa-miR-9-5p RALGDS -2.23538606210968 1.28143998950751e-12 1.09793021618138 3.44535423332662e-31 miRNATAP -0.109445048589154 1.58868218616664e-10 NA NA NA hsa-miR-101-5p RAP1B -0.710089604234471 1.19159750684491e-09 0.286208775671425 7.37540638959961e-08 MirTarget -0.109458505991147 9.08978722827426e-06 24697700 Functional analysis of miR 101 3p and Rap1b involved in hepatitis B virus related hepatocellular carcinoma pathogenesis liver cancer hsa-miR-27b-3p RAP1B -0.699527231242518 1.07356023759234e-15 0.286208775671425 7.37540638959961e-08 MirTarget -0.176368695618954 4.57827183852651e-08 NA NA NA hsa-miR-30a-5p RAP1B -0.778411951775343 2.73322451127932e-16 0.286208775671425 7.37540638959961e-08 MirTarget;miRNATAP -0.157900294407933 8.71698303133625e-08 NA NA NA hsa-miR-30b-5p RAP1B -1.18330589477119 6.8341618466966e-27 0.286208775671425 7.37540638959961e-08 MirTarget -0.116076136600269 2.44395548782544e-06 NA NA NA hsa-miR-30c-5p RAP1B -1.08783070774238 2.02505402525786e-24 0.286208775671425 7.37540638959961e-08 MirTarget;miRNATAP -0.107723639556347 2.89701994201079e-05 NA NA NA hsa-miR-30d-5p RAP1B -0.202727675788184 0.00659067084745794 0.286208775671425 7.37540638959961e-08 MirTarget;miRNATAP -0.149796748802348 0.000185581330380838 NA NA NA hsa-miR-10a-3p RAPGEF5 -1.40380922426511 3.42207767326254e-23 0.812947544141447 5.66108478295081e-11 mirMAP -0.260428114175326 2.47181748205147e-08 NA NA NA hsa-miR-125b-5p RAPGEF5 -0.825456421494266 2.13029877878434e-15 0.812947544141447 5.66108478295081e-11 MirTarget -0.299188766018968 3.41996481524126e-06 NA NA NA hsa-miR-141-3p RAPGEF5 -5.87110686537457 1.20877726722907e-85 0.812947544141447 5.66108478295081e-11 MirTarget -0.143951537037905 9.24881661223574e-17 NA NA NA hsa-miR-148a-5p RAPGEF5 0.415500302855613 0.000691460831436767 0.812947544141447 5.66108478295081e-11 mirMAP -0.19181208243337 0.000803137949310474 NA NA NA hsa-miR-182-5p RAPGEF5 -0.608710746044567 0.0025264935278104 0.812947544141447 5.66108478295081e-11 MirTarget -0.196386487924614 8.58972878213273e-09 NA NA NA hsa-miR-200a-3p RAPGEF5 -1.43409013664263 2.00188483717828e-20 0.812947544141447 5.66108478295081e-11 MirTarget -0.185273542056455 1.27866686454103e-05 NA NA NA hsa-miR-29a-5p RAPGEF5 -0.519003718107105 1.03351148282116e-06 0.812947544141447 5.66108478295081e-11 mirMAP -0.356880707952619 3.18034645598261e-08 NA NA NA hsa-miR-335-3p RAPGEF5 -1.36498175550207 6.84287752180534e-13 0.812947544141447 5.66108478295081e-11 mirMAP -0.123007540160956 0.000568433801641932 NA NA NA hsa-miR-363-3p RAPGEF5 -1.93551166555337 4.45368477487614e-32 0.812947544141447 5.66108478295081e-11 mirMAP -0.186906941386929 1.16369285821228e-06 NA NA NA hsa-miR-508-3p RAPGEF5 -3.41433288024917 3.47699261121175e-37 0.812947544141447 5.66108478295081e-11 miRNATAP -0.11493427902629 6.83758002568813e-07 NA NA NA hsa-miR-664a-5p RAPGEF5 -0.618481839889218 7.01961389909184e-09 0.812947544141447 5.66108478295081e-11 mirMAP -0.252655510766869 8.83810171244687e-05 NA NA NA hsa-miR-24-3p RASA1 0.173813044685099 0.00565259443420961 0.0217286156818641 0.75657862415223 MirTarget;miRNATAP -0.320385426359283 1.81314237484709e-07 NA NA NA hsa-miR-26a-5p RASA1 -0.202091714279613 0.00166918288801054 0.0217286156818641 0.75657862415223 miRNAWalker2_validate -0.182327992810041 0.00264769232284362 NA NA NA hsa-miR-30b-5p RASA1 -1.18330589477119 6.8341618466966e-27 0.0217286156818641 0.75657862415223 MirTarget -0.128210708164226 6.18645358602785e-05 NA NA NA hsa-miR-30b-5p RASA2 -1.18330589477119 6.8341618466966e-27 -0.155624188098594 0.195395998553973 mirMAP -0.177814784836538 0.00131875058405262 NA NA NA hsa-miR-139-5p RASA3 -0.704802495091118 2.36904108453776e-06 1.51324741852573 6.44931621764209e-50 miRanda -0.116554532782629 0.00728472540534982 NA NA NA hsa-miR-335-5p RASA3 -2.09515619961552 1.03765771499548e-25 1.51324741852573 6.44931621764209e-50 miRNAWalker2_validate -0.177996680144131 3.09066031714988e-09 NA NA NA hsa-miR-141-3p RASA4 -5.87110686537457 1.20877726722907e-85 0.572396560145369 2.78980371330124e-06 mirMAP -0.113774333184185 2.81506079353648e-11 NA NA NA hsa-miR-200a-3p RASA4 -1.43409013664263 2.00188483717828e-20 0.572396560145369 2.78980371330124e-06 mirMAP -0.134791008538267 0.0011340048855169 NA NA NA hsa-miR-330-5p RASAL1 1.44960468659754 2.12131210588035e-45 -1.21472018743045 1.20122623214918e-07 miRanda -0.40134819157827 0.000235816120157095 NA NA NA hsa-miR-342-3p RASAL1 1.4124432570595 1.07208971556131e-28 -1.21472018743045 1.20122623214918e-07 miRanda -0.391268128104527 2.27814921779746e-05 NA NA NA hsa-miR-107 RASAL2 0.140046250553248 0.0943611632552367 0.00447352440078053 0.956808481909249 miRanda -0.153712616578149 0.00499684462700375 NA NA NA hsa-miR-130b-3p RASAL2 1.12788913578446 2.939369462276e-16 0.00447352440078053 0.956808481909249 mirMAP -0.104768061101233 0.000833323481724373 NA NA NA hsa-miR-148a-5p RASAL2 0.415500302855613 0.000691460831436767 0.00447352440078053 0.956808481909249 mirMAP -0.208375229921849 8.5611326099625e-09 NA NA NA hsa-miR-29a-3p RASAL2 -0.431613225927952 4.10166815070288e-08 0.00447352440078053 0.956808481909249 MirTarget -0.315637627518144 1.86681847878184e-08 NA NA NA hsa-miR-29b-3p RASAL2 -0.228125979913806 0.0271621721891603 0.00447352440078053 0.956808481909249 MirTarget -0.296634145580157 4.05837943067974e-12 NA NA NA hsa-miR-29c-3p RASAL2 -0.238671318446745 0.0141475322347596 0.00447352440078053 0.956808481909249 MirTarget -0.1865313640871 6.11833236345166e-05 NA NA NA hsa-miR-339-5p RASAL2 0.322848334531193 0.0117281778821612 0.00447352440078053 0.956808481909249 PITA -0.155240442742998 9.62342121929493e-06 NA NA NA hsa-miR-590-3p RASAL2 1.13702599385212 3.53435739887793e-22 0.00447352440078053 0.956808481909249 MirTarget;miRanda;mirMAP -0.130205789598432 0.000312950564145575 NA NA NA hsa-miR-590-5p RASAL2 0.709763558412506 1.11883921359361e-11 0.00447352440078053 0.956808481909249 MirTarget;miRanda -0.130379920341547 0.00198215302174747 NA NA NA hsa-miR-616-5p RASAL2 0.913426384742148 3.78418389333709e-09 0.00447352440078053 0.956808481909249 mirMAP -0.116824515864165 5.18219813460428e-05 NA NA NA hsa-miR-625-5p RASAL2 0.153090549230629 0.330314026509869 0.00447352440078053 0.956808481909249 MirTarget -0.16507582637415 8.43000456275015e-08 NA NA NA hsa-miR-106b-5p RASGRF2 1.07509411417907 2.11739194181878e-36 -0.161186180108779 0.261117228287715 MirTarget -0.40247570153502 9.83767139579981e-07 NA NA NA hsa-miR-146b-5p RASGRF2 1.40714170253819 2.9559871816487e-12 -0.161186180108779 0.261117228287715 miRanda -0.196529611245711 1.31111712072467e-07 NA NA NA hsa-miR-17-5p RASGRF2 0.494260110870015 3.8348005261e-09 -0.161186180108779 0.261117228287715 MirTarget;TargetScan -0.271656502011799 0.00342072931959185 NA NA NA hsa-miR-182-5p RASGRF2 -0.608710746044567 0.0025264935278104 -0.161186180108779 0.261117228287715 mirMAP -0.171751087687878 8.67724615166908e-06 NA NA NA hsa-miR-28-5p RASGRF2 0.461962042257226 3.32424690573327e-11 -0.161186180108779 0.261117228287715 miRanda -0.409446533227333 0.000232341243378579 NA NA NA hsa-miR-421 RASGRF2 0.313155739887734 0.020433534776003 -0.161186180108779 0.261117228287715 miRanda;mirMAP -0.18846514780393 0.00178172434768131 NA NA NA hsa-miR-590-3p RASGRF2 1.13702599385212 3.53435739887793e-22 -0.161186180108779 0.261117228287715 MirTarget;miRanda -0.205219058897356 0.00113417568115945 NA NA NA hsa-miR-590-5p RASGRF2 0.709763558412506 1.11883921359361e-11 -0.161186180108779 0.261117228287715 miRanda -0.19856058327869 0.00695333530181574 NA NA NA hsa-miR-664a-3p RASGRF2 -0.019312777079624 0.825861598748857 -0.161186180108779 0.261117228287715 mirMAP -0.247653262246371 0.00655023804824046 NA NA NA hsa-miR-93-5p RASGRF2 1.37365940377595 2.37567548683245e-46 -0.161186180108779 0.261117228287715 MirTarget -0.205862485013484 0.00393310909917406 NA NA NA hsa-miR-221-3p RASGRP1 0.337895669520713 0.0136448974691037 -0.16513553750872 0.228493491156229 MirTarget -0.228029513724262 3.05823699260709e-05 NA NA NA hsa-miR-2355-3p RASGRP1 1.32757890426926 1.88016636795886e-18 -0.16513553750872 0.228493491156229 MirTarget -0.181112949286381 0.000174129414860136 NA NA NA hsa-miR-324-3p RASGRP2 -0.197662887871899 0.0298845059559819 0.898317692830448 5.31223171890133e-10 PITA -0.358794785893776 7.13151243987706e-05 NA NA NA hsa-miR-199a-5p RASGRP3 -1.64658415208633 1.01615659358973e-23 1.00655968098869 8.4255907167779e-28 miRanda -0.135668029138639 1.28544339252798e-05 NA NA NA hsa-miR-199b-5p RASGRP3 -2.39483476763681 1.04659509514884e-17 1.00655968098869 8.4255907167779e-28 miRanda -0.136039714409104 2.1046829766018e-13 NA NA NA hsa-miR-362-3p RASGRP3 -0.753214251798232 3.0025661608035e-07 1.00655968098869 8.4255907167779e-28 miRanda -0.18918287165185 5.17882895854091e-07 NA NA NA hsa-miR-589-3p RASGRP3 -0.0184909376114044 0.903149951095234 1.00655968098869 8.4255907167779e-28 mirMAP -0.118420434580306 0.00143733546029292 NA NA NA hsa-miR-30b-3p RASGRP4 -1.64703050862226 1.89878531036464e-31 2.06336765912974 4.01956478625706e-40 MirTarget -0.560900719729812 3.08136423056342e-21 NA NA NA hsa-miR-577 RASGRP4 -1.48881999472397 7.03080165111147e-10 2.06336765912974 4.01956478625706e-40 miRNATAP -0.244791285106805 1.99817241505552e-10 NA NA NA hsa-miR-429 RASSF1 -2.16569233119434 2.66862243626443e-37 0.627514156520288 6.01360653275305e-17 miRNATAP -0.121144042598097 6.14216894087611e-08 NA NA NA hsa-miR-744-5p RASSF1 -0.348985243196771 0.000187889982228835 0.627514156520288 6.01360653275305e-17 miRNAWalker2_validate -0.13091916416799 0.00479302734956156 NA NA NA hsa-miR-125a-5p RASSF5 -0.561874059994802 7.3931856356891e-13 1.72017913807372 3.17159592274149e-36 miRanda -0.78393282292648 9.92983685667287e-15 NA NA NA hsa-miR-335-5p RASSF5 -2.09515619961552 1.03765771499548e-25 1.72017913807372 3.17159592274149e-36 miRNAWalker2_validate -0.214941578954791 3.00278876495923e-08 NA NA NA hsa-miR-532-5p RASSF5 -1.09700348358668 8.34836230254408e-26 1.72017913807372 3.17159592274149e-36 PITA;miRNATAP -0.542515378805808 6.98571139155521e-14 NA NA NA hsa-miR-16-1-3p REL 1.51429140700091 3.17219833254498e-37 -0.604331426229612 2.28449873998646e-05 MirTarget -0.192986725223218 0.00144827492028754 NA NA NA hsa-miR-30e-5p RELA -0.0905907245198101 0.21196704484334 0.305834629484614 4.05322273913174e-11 miRNAWalker2_validate -0.103369294516701 0.00471206012122476 NA NA NA hsa-miR-135b-5p RGL1 -1.12731059106515 6.06922867778145e-08 0.660350319729454 3.70908973110628e-09 MirTarget -0.125631785494048 2.40167810690105e-05 NA NA NA hsa-miR-182-5p RGL1 -0.608710746044567 0.0025264935278104 0.660350319729454 3.70908973110628e-09 MirTarget -0.200832356841128 3.65460298130124e-11 NA NA NA hsa-miR-200b-3p RGL1 -1.70383252137161 2.38979336321755e-30 0.660350319729454 3.70908973110628e-09 MirTarget;TargetScan -0.232342027667314 7.93408992471774e-10 NA NA NA hsa-miR-200c-3p RGL1 -5.40303134829523 2.74173143360645e-94 0.660350319729454 3.70908973110628e-09 MirTarget;miRNATAP -0.149155705954824 3.47762450995775e-18 NA NA NA hsa-miR-335-3p RGL1 -1.36498175550207 6.84287752180534e-13 0.660350319729454 3.70908973110628e-09 mirMAP -0.115198639713611 0.000315864550786998 NA NA NA hsa-miR-429 RGL1 -2.16569233119434 2.66862243626443e-37 0.660350319729454 3.70908973110628e-09 MirTarget;PITA;miRanda;miRNATAP -0.153046299707597 3.03465491505558e-06 NA NA NA hsa-miR-96-5p RGL1 -1.00223771166604 3.91564621567028e-06 0.660350319729454 3.70908973110628e-09 mirMAP -0.209283141306657 2.4463947647617e-13 NA NA NA hsa-miR-106b-5p RRAS2 1.07509411417907 2.11739194181878e-36 -0.44234311736897 6.43194882105622e-09 miRNATAP -0.124383561814842 0.00594749690734943 NA NA NA hsa-miR-140-3p RRAS2 0.989350547007025 6.14964028267239e-25 -0.44234311736897 6.43194882105622e-09 MirTarget;PITA;miRNATAP -0.245191563810215 1.8200293337363e-09 NA NA NA hsa-miR-20a-5p RRAS2 0.702602695798242 4.06372887613329e-13 -0.44234311736897 6.43194882105622e-09 miRNATAP -0.170571071949194 6.41677814266269e-05 NA NA NA hsa-miR-23a-3p RRAS2 0.761438723382355 4.09310879199257e-27 -0.44234311736897 6.43194882105622e-09 MirTarget;miRNATAP -0.206152149089032 0.00025734992372647 NA NA NA hsa-miR-320a RRAS2 0.412740558379182 2.02929519701706e-05 -0.44234311736897 6.43194882105622e-09 miRanda -0.117093853573067 0.00795461126952592 NA NA NA hsa-miR-93-5p RRAS2 1.37365940377595 2.37567548683245e-46 -0.44234311736897 6.43194882105622e-09 miRNAWalker2_validate -0.146914012234231 0.000140590207004362 NA NA NA hsa-miR-10a-3p SHC1 -1.40380922426511 3.42207767326254e-23 1.04527076741494 1.18224577291405e-41 mirMAP -0.232016432401323 2.12810671732675e-13 NA NA NA hsa-miR-10a-5p SHC1 -1.17164272592931 4.86621098042279e-24 1.04527076741494 1.18224577291405e-41 miRNATAP -0.329473870268413 5.14859535548191e-19 NA NA NA hsa-miR-10b-5p SHC1 -0.89971464210447 1.18190532299934e-20 1.04527076741494 1.18224577291405e-41 miRNATAP -0.357390182085889 4.7250364005311e-15 NA NA NA hsa-miR-141-3p SHC1 -5.87110686537457 1.20877726722907e-85 1.04527076741494 1.18224577291405e-41 miRNAWalker2_validate -0.13186070911579 3.79357196856314e-31 NA NA NA hsa-miR-200a-3p SHC1 -1.43409013664263 2.00188483717828e-20 1.04527076741494 1.18224577291405e-41 miRNAWalker2_validate -0.246699691039654 1.11709757832569e-18 NA NA NA hsa-miR-200b-3p SHC1 -1.70383252137161 2.38979336321755e-30 1.04527076741494 1.18224577291405e-41 miRNAWalker2_validate;TargetScan -0.302526669583532 1.14952919002391e-28 NA NA NA hsa-miR-200c-3p SHC1 -5.40303134829523 2.74173143360645e-94 1.04527076741494 1.18224577291405e-41 miRNAWalker2_validate;miRNATAP -0.152952104781014 1.39622579696442e-34 NA NA NA hsa-miR-204-5p SHC1 -1.67490789640238 9.14741888352476e-10 1.04527076741494 1.18224577291405e-41 MirTarget;miRNATAP -0.131305751802594 2.08531674264206e-15 NA NA NA hsa-miR-30b-3p SHC1 -1.64703050862226 1.89878531036464e-31 1.04527076741494 1.18224577291405e-41 MirTarget;miRNATAP -0.322237455298868 4.03003956254282e-29 NA NA NA hsa-miR-30b-5p SHC1 -1.18330589477119 6.8341618466966e-27 1.04527076741494 1.18224577291405e-41 miRNAWalker2_validate -0.318746312530365 2.47529705019197e-16 NA NA NA hsa-miR-429 SHC1 -2.16569233119434 2.66862243626443e-37 1.04527076741494 1.18224577291405e-41 miRNAWalker2_validate;miRNATAP -0.25110779147193 1.12349600110136e-26 NA NA NA hsa-miR-21-3p SHC3 1.78837590049697 1.41655409877312e-33 -2.66568879419971 5.24585737966314e-34 MirTarget -0.556446097044537 2.37813839310345e-12 NA NA NA hsa-miR-331-5p SHC3 0.661186030542026 1.83628790002785e-08 -2.66568879419971 5.24585737966314e-34 PITA;miRNATAP -0.352717931557855 0.00263482932136152 NA NA NA hsa-miR-590-5p SHC3 0.709763558412506 1.11883921359361e-11 -2.66568879419971 5.24585737966314e-34 miRanda -0.414266528804263 0.000923437672513631 NA NA NA hsa-miR-151a-3p SHC4 0.657909055193034 1.46651056355997e-25 -0.0964950431872964 0.49848126461133 MirTarget -0.38786351042597 0.000920355819744857 NA NA NA hsa-miR-361-5p SHC4 0.0514169367202078 0.382929376393199 -0.0964950431872964 0.49848126461133 miRanda -0.543256987567086 6.48145291363322e-05 NA NA NA hsa-let-7a-3p SHOC2 0.0677487960013088 0.460458477653989 -0.196994225678113 0.000223493046777059 MirTarget -0.102002980979034 0.00163631085614812 NA NA NA hsa-miR-106b-5p SHOC2 1.07509411417907 2.11739194181878e-36 -0.196994225678113 0.000223493046777059 MirTarget;miRNATAP -0.152013016873334 7.1436946188662e-07 NA NA NA hsa-miR-361-5p SHOC2 0.0514169367202078 0.382929376393199 -0.196994225678113 0.000223493046777059 PITA;miRanda -0.132615076291593 0.00995510168953605 NA NA NA hsa-miR-22-5p SOS1 -0.197038086012602 0.106234828461117 0.165657937822672 0.00695508624793917 miRNATAP -0.1259671249937 4.71993758199897e-06 NA NA NA hsa-miR-27b-3p SOS1 -0.699527231242518 1.07356023759234e-15 0.165657937822672 0.00695508624793917 MirTarget;miRNATAP -0.147080230611449 7.31565228121447e-05 NA NA NA hsa-miR-30b-5p SOS1 -1.18330589477119 6.8341618466966e-27 0.165657937822672 0.00695508624793917 mirMAP -0.138149072736721 7.79904823834726e-07 NA NA NA hsa-miR-361-5p SOS1 0.0514169367202078 0.382929376393199 0.165657937822672 0.00695508624793917 miRanda -0.17245343753156 0.00341644954529283 NA NA NA hsa-miR-130b-3p SOS2 1.12788913578446 2.939369462276e-16 -0.603803978860436 7.13914474388309e-16 miRNATAP -0.219389641555847 2.49951089457902e-14 NA NA NA hsa-miR-146b-5p SOS2 1.40714170253819 2.9559871816487e-12 -0.603803978860436 7.13914474388309e-16 miRanda -0.147776164302161 1.19506749629666e-13 NA NA NA hsa-miR-15a-5p SOS2 1.42663930007845 1.36006952074963e-57 -0.603803978860436 7.13914474388309e-16 miRNATAP -0.253370307078702 1.58238296990946e-10 NA NA NA hsa-miR-15b-5p SOS2 0.773001494057531 1.71784656078957e-16 -0.603803978860436 7.13914474388309e-16 miRNATAP -0.335211578081185 2.30658617778889e-15 NA NA NA hsa-miR-16-5p SOS2 0.934012514027655 4.85417898318515e-24 -0.603803978860436 7.13914474388309e-16 miRNATAP -0.24200816200432 1.67224378158762e-08 NA NA NA hsa-miR-193a-3p SOS2 0.849206638484406 3.68101781083335e-14 -0.603803978860436 7.13914474388309e-16 PITA;miRanda;miRNATAP -0.269886140589803 4.58383896803507e-14 NA NA NA hsa-miR-21-5p SOS2 2.51462371613332 3.30620591950316e-66 -0.603803978860436 7.13914474388309e-16 miRNATAP -0.237021856922544 1.01167070366515e-26 NA NA NA hsa-miR-301a-3p SOS2 0.259400847075798 0.0216890736701418 -0.603803978860436 7.13914474388309e-16 miRNATAP -0.116740679991895 0.00226202627325341 NA NA NA hsa-miR-320a SOS2 0.412740558379182 2.02929519701706e-05 -0.603803978860436 7.13914474388309e-16 miRanda;miRNATAP -0.205432651949533 2.81576440891282e-06 NA NA NA hsa-miR-320b SOS2 0.300497419754843 0.0245219177384172 -0.603803978860436 7.13914474388309e-16 miRanda;miRNATAP -0.152878780959194 1.68250949578106e-06 NA NA NA hsa-miR-454-3p SOS2 0.68285296887698 1.17407812677787e-08 -0.603803978860436 7.13914474388309e-16 miRNATAP -0.1714669429965 9.02571972797797e-07 NA NA NA hsa-miR-590-3p SOS2 1.13702599385212 3.53435739887793e-22 -0.603803978860436 7.13914474388309e-16 miRanda;mirMAP -0.229417057761137 7.37633999411141e-12 NA NA NA hsa-miR-590-5p SOS2 0.709763558412506 1.11883921359361e-11 -0.603803978860436 7.13914474388309e-16 PITA;miRanda;miRNATAP -0.223093386542166 1.51960822756839e-08 NA NA NA hsa-miR-130a-3p STK4 -0.667386596699886 1.34029167767774e-10 0.812587681451308 9.24559425127492e-33 MirTarget;mirMAP -0.150595146243729 0.000105265135826938 NA NA NA hsa-miR-139-5p STK4 -0.704802495091118 2.36904108453776e-06 0.812587681451308 9.24559425127492e-33 miRanda -0.167272662538038 4.28071599198894e-10 NA NA NA hsa-miR-199a-5p STK4 -1.64658415208633 1.01615659358973e-23 0.812587681451308 9.24559425127492e-33 MirTarget;PITA;miRanda;miRNATAP -0.104969524328074 6.82040198362499e-06 NA NA NA hsa-miR-200a-5p STK4 -1.36295040293874 1.31587720312419e-22 0.812587681451308 9.24559425127492e-33 MirTarget -0.183794923274184 1.11662460725027e-11 NA NA NA hsa-miR-200b-3p STK4 -1.70383252137161 2.38979336321755e-30 0.812587681451308 9.24559425127492e-33 MirTarget -0.211400064540612 1.88154390793387e-18 NA NA NA hsa-miR-200b-5p STK4 -1.46985752435972 3.43232443788022e-27 0.812587681451308 9.24559425127492e-33 MirTarget -0.203110608289506 9.84387964390789e-14 NA NA NA hsa-miR-200c-3p STK4 -5.40303134829523 2.74173143360645e-94 0.812587681451308 9.24559425127492e-33 MirTarget -0.112899861655554 1.39768123125122e-24 NA NA NA hsa-miR-23b-3p STK4 -0.533749586990474 2.46924776953771e-10 0.812587681451308 9.24559425127492e-33 MirTarget;miRNATAP -0.260460395571831 4.34542494357977e-08 NA NA NA hsa-miR-3065-3p STK4 -1.64500070417457 9.57561660036697e-16 0.812587681451308 9.24559425127492e-33 miRNATAP -0.130463352401494 3.53260050857078e-12 NA NA NA hsa-miR-30a-3p STK4 -0.955360819934585 1.97009535429185e-20 0.812587681451308 9.24559425127492e-33 mirMAP -0.340407888136901 1.73194936770955e-21 NA NA NA hsa-miR-30b-3p STK4 -1.64703050862226 1.89878531036464e-31 0.812587681451308 9.24559425127492e-33 MirTarget -0.235606196500993 1.40891013553816e-20 NA NA NA hsa-miR-30b-5p STK4 -1.18330589477119 6.8341618466966e-27 0.812587681451308 9.24559425127492e-33 mirMAP -0.306506286975994 8.96305672286683e-21 NA NA NA hsa-miR-30c-2-3p STK4 -1.28402709024345 6.77577627955178e-25 0.812587681451308 9.24559425127492e-33 MirTarget -0.354458666348077 6.80043237079793e-38 NA NA NA hsa-miR-30c-5p STK4 -1.08783070774238 2.02505402525786e-24 0.812587681451308 9.24559425127492e-33 mirMAP -0.285074522756459 2.0296965155174e-16 NA NA NA hsa-miR-30d-3p STK4 -0.249777194282131 0.00235356711813496 0.812587681451308 9.24559425127492e-33 mirMAP -0.322860692759468 7.48372429238388e-11 NA NA NA hsa-miR-30d-5p STK4 -0.202727675788184 0.00659067084745794 0.812587681451308 9.24559425127492e-33 mirMAP -0.268736756279182 1.35864047556866e-06 NA NA NA hsa-miR-30e-3p STK4 -0.205602546270795 0.00132666419729688 0.812587681451308 9.24559425127492e-33 mirMAP -0.261792966485923 6.33484563047979e-05 NA NA NA hsa-miR-361-5p STK4 0.0514169367202078 0.382929376393199 0.812587681451308 9.24559425127492e-33 mirMAP -0.202892193826623 0.00510831228547249 NA NA NA hsa-miR-362-5p STK4 -2.72767654824605 1.34821749679113e-49 0.812587681451308 9.24559425127492e-33 mirMAP -0.183909199883309 1.04071423214531e-24 NA NA NA hsa-miR-429 STK4 -2.16569233119434 2.66862243626443e-37 0.812587681451308 9.24559425127492e-33 MirTarget;miRanda;miRNATAP -0.200797731102117 5.91117655030092e-23 NA NA NA hsa-miR-500a-5p STK4 -1.28374735824553 1.95870374809798e-20 0.812587681451308 9.24559425127492e-33 MirTarget -0.181990304046837 3.68241449887039e-11 NA NA NA hsa-miR-501-5p STK4 -1.1103073934745 1.81589804886553e-16 0.812587681451308 9.24559425127492e-33 MirTarget;miRNATAP -0.193643595834238 1.18325325383517e-11 NA NA NA hsa-miR-664a-5p STK4 -0.618481839889218 7.01961389909184e-09 0.812587681451308 9.24559425127492e-33 MirTarget -0.140167469776626 0.000227652382392364 NA NA NA hsa-let-7g-3p SYNGAP1 -0.265047454512772 0.0213585204640049 0.363968089019745 6.211378635897e-05 miRNATAP -0.243339683441389 1.75933697765194e-08 NA NA NA hsa-miR-29a-3p SYNGAP1 -0.431613225927952 4.10166815070288e-08 0.363968089019745 6.211378635897e-05 miRNATAP -0.218426130725105 0.000583514232313273 NA NA NA hsa-miR-29b-3p SYNGAP1 -0.228125979913806 0.0271621721891603 0.363968089019745 6.211378635897e-05 miRNATAP -0.2972675993386 6.04430523756544e-10 NA NA NA hsa-miR-30b-3p SYNGAP1 -1.64703050862226 1.89878531036464e-31 0.363968089019745 6.211378635897e-05 mirMAP -0.169877476825876 1.33406957800902e-07 NA NA NA hsa-miR-324-3p SYNGAP1 -0.197662887871899 0.0298845059559819 0.363968089019745 6.211378635897e-05 PITA;miRNATAP -0.238382621642401 1.80026931586595e-05 NA NA NA hsa-miR-331-3p SYNGAP1 0.431607034018882 6.83022920590941e-05 0.363968089019745 6.211378635897e-05 PITA;mirMAP;miRNATAP -0.182451562910072 7.63446090683209e-05 NA NA NA hsa-miR-339-5p SYNGAP1 0.322848334531193 0.0117281778821612 0.363968089019745 6.211378635897e-05 PITA;miRNATAP -0.160463926641514 4.21947109683631e-05 NA NA NA hsa-miR-491-5p SYNGAP1 -0.0898777415179634 0.533906535063567 0.363968089019745 6.211378635897e-05 PITA;miRanda;miRNATAP -0.106364210092965 0.00385502239642941 NA NA NA hsa-miR-625-5p SYNGAP1 0.153090549230629 0.330314026509869 0.363968089019745 6.211378635897e-05 mirMAP -0.139329744944253 5.86229326336575e-05 NA NA NA hsa-miR-421 TEK 0.313155739887734 0.020433534776003 -1.65542932804087 8.29595799035816e-24 miRanda -0.258669265792757 0.000513564139358755 NA NA NA hsa-miR-455-5p TEK 0.773674551205946 2.12957541541474e-09 -1.65542932804087 8.29595799035816e-24 miRanda -0.206901755871524 0.00512583155936728 NA NA NA hsa-miR-127-3p TGFA -1.21389348740811 1.68387193137287e-11 1.36512772495958 8.9535894410598e-16 miRanda -0.235441109326585 6.39796952246005e-06 NA NA NA hsa-miR-199a-5p TGFA -1.64658415208633 1.01615659358973e-23 1.36512772495958 8.9535894410598e-16 miRNATAP -0.255748841194025 3.38916021852312e-06 NA NA NA hsa-miR-199b-5p TGFA -2.39483476763681 1.04659509514884e-17 1.36512772495958 8.9535894410598e-16 miRNATAP -0.226367264952936 7.28652915602024e-12 NA NA NA hsa-miR-29a-5p TGFA -0.519003718107105 1.03351148282116e-06 1.36512772495958 8.9535894410598e-16 mirMAP -0.356697291857125 8.62237034540277e-05 NA NA NA hsa-miR-33a-5p TGFA -1.59840463890997 1.13487952314403e-18 1.36512772495958 8.9535894410598e-16 mirMAP -0.339922665464381 1.02399423426662e-11 NA NA NA hsa-miR-429 TGFA -2.16569233119434 2.66862243626443e-37 1.36512772495958 8.9535894410598e-16 miRanda;miRNATAP -0.149026559422325 0.00374093991912977 NA NA NA hsa-miR-10a-5p TIAM1 -1.17164272592931 4.86621098042279e-24 0.181791080507497 0.102093724789682 MirTarget;miRNATAP -0.20240186714485 3.51481633349348e-05 26870215 Expression of microRNA 10a microRNA 342 3p and their predicted target gene TIAM1 in extranodal NK/T cell lymphoma nasal type; In the present study the association between the expression levels of miR-10a and miR-342-3p and the protein expression levels of TIAM1 was examined in ENKTCL tissues lymphoma hsa-miR-361-5p TIAM1 0.0514169367202078 0.382929376393199 0.181791080507497 0.102093724789682 miRanda -0.323954321287275 0.00240574522798868 NA NA NA hsa-miR-362-3p TIAM1 -0.753214251798232 3.0025661608035e-07 0.181791080507497 0.102093724789682 miRanda -0.180270743920477 1.73009200619043e-05 NA NA NA hsa-miR-1-3p VEGFA -1.38047704190737 9.11649491260066e-13 3.1902151031465 4.32161998112301e-60 MirTarget -0.377004508862683 2.92409820832604e-09 24966896 The ectopic expression of miR-1 and miR-145 in NOZ cells significantly inhibited cell viability and colony formation P<0.01 and reduced gene expression of VEGF-A and AXL bladder cancer hsa-miR-106a-5p VEGFA -0.830908656792615 2.67547872901508e-10 3.1902151031465 4.32161998112301e-60 miRNAWalker2_validate;miRTarBase -0.565883993248695 1.96742640916183e-09 NA NA NA hsa-miR-125a-5p VEGFA -0.561874059994802 7.3931856356891e-13 3.1902151031465 4.32161998112301e-60 miRNAWalker2_validate;miRanda -0.691987422405189 1.65186087473265e-05 22768249 Ectopic expression of MiR 125a inhibits the proliferation and metastasis of hepatocellular carcinoma by targeting MMP11 and VEGF; Furthermore miR-125a expression was inversely correlated with both MMP11 and VEGF-A expression in HCC tissues; MiR-125a inhibits the proliferation and metastasis of HCC by targeting MMP11 and VEGF-A metastasis liver cancer hsa-miR-133a-3p VEGFA -1.27121745308165 9.16266399887975e-11 3.1902151031465 4.32161998112301e-60 miRNAWalker2_validate -0.334559517340425 1.60041057990039e-07 NA NA NA hsa-miR-134-5p VEGFA -0.940639322366899 1.24417590236773e-06 3.1902151031465 4.32161998112301e-60 miRNAWalker2_validate;miRTarBase;MirTarget -0.273283677460691 3.09936265314409e-05 NA NA NA hsa-miR-199a-5p VEGFA -1.64658415208633 1.01615659358973e-23 3.1902151031465 4.32161998112301e-60 miRanda;miRNATAP -0.582562369754787 1.33420730972332e-16 25444917 In addition co-transfection with miR-199a mimic reversed the CCL5-mediated VEGF expression and angiogenesis in vitro and in vivo sarcoma hsa-miR-199b-5p VEGFA -2.39483476763681 1.04659509514884e-17 3.1902151031465 4.32161998112301e-60 miRanda -0.388055722385546 8.86533920644866e-20 NA NA NA hsa-miR-200b-3p VEGFA -1.70383252137161 2.38979336321755e-30 3.1902151031465 4.32161998112301e-60 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.652162092625576 6.74456951743668e-18 20420713;22904162;25301739 We also found strong anti-correlation between VEGFA and the miR-200 family of microRNA: miR-200a* 200b 200c and miR-141;In contrast a positive correlation was observed between VEGF-A and miR-200b and -210;CCL5 promotes VEGF dependent angiogenesis by down regulating miR 200b through PI3K/Akt signaling pathway in human chondrosarcoma cells; We also demonstrated CCL5 inhibiting miR-200b expression and miR-200b mimic reversing the CCL5-enhanced VEGF expression and angiogenesis ;; kidney renal cell cancer;endometrial cancer;sarcoma hsa-miR-200c-3p VEGFA -5.40303134829523 2.74173143360645e-94 3.1902151031465 4.32161998112301e-60 miRNAWalker2_validate;miRTarBase;MirTarget -0.482839305599163 5.43978252023974e-53 24205206;25445393 MiR 200c increases the radiosensitivity of non small cell lung cancer cell line A549 by targeting VEGF VEGFR2 pathway;Analysis revealed a negative correlation between miR-200c and VEGFA expressions r=-468 ; lung squamous cell cancer;breast cancer hsa-miR-20b-5p VEGFA -1.30218163823367 6.87172815978149e-17 3.1902151031465 4.32161998112301e-60 miRNAWalker2_validate;miRTarBase -0.658858628437659 2.63194222583861e-18 22901144;20232316;26612965 Correlation analysis showed that the key miRNAs miR-20a and miR-20b negatively correlated with the target proteins VEGF-A and HIF-1alpha;We investigated whether and how miR-20b can regulate the expression of vascular endothelial growth factor VEGF in MCF-7 breast cancer cells under normoxic and hypoxia-mimicking conditions CoCl2 exposure; Using immunoblotting ELISA and quantitative real-time PCR we demonstrated that miR-20b decreased VEGF protein levels at 4 and 24 h following CoCl2 treatment and VEGF mRNA at 4 h of treatment; In addition miR-20b reduced VEGF protein expression in untreated cells;Clinicopathological Significance of MicroRNA 20b Expression in Hepatocellular Carcinoma and Regulation of HIF 1α and VEGF Effect on Cell Biological Behaviour; Meanwhile the HIF-1α and VEGF targets of miR-20b have been confirmed; We found not only miR-20b regulation of HIF-1α and VEGF in normal but also regulation of miR-20b in hypoxia; The whole study suggests that miR-20b HIF-1α and VEGF serve as a potential therapeutic agent for hepatocellular carcinoma ;; breast cancer;breast cancer;liver cancer hsa-miR-29a-3p VEGFA -0.431613225927952 4.10166815070288e-08 3.1902151031465 4.32161998112301e-60 MirTarget -1.19030784245849 4.8715212353082e-14 24209632 miR 29a suppresses growth and invasion of gastric cancer cells in vitro by targeting VEGF A; Furthermore western blot combined with the luciferase reporter assays demonstrate that vascular endothelial growth factor A VEGF-A is direct target of miR-29a; This is the first time miR-29a was found to suppress the tumor microvessel density in gastric cancer by targeting VEGF-A gastric cancer hsa-miR-29b-2-5p VEGFA -0.297854154636098 0.00260919277325581 3.1902151031465 4.32161998112301e-60 MirTarget -0.376634138151447 0.00423612473269059 NA NA NA hsa-miR-29b-3p VEGFA -0.228125979913806 0.0271621721891603 3.1902151031465 4.32161998112301e-60 miRNAWalker2_validate;miRTarBase;MirTarget -0.569482283980511 5.47301472525388e-06 26155940;22815235 Moreover miR-29b inhibits angiogenesis by attenuating tube formation and the expression of VEGF and Ang-2 and stemness maintenance in GBM cells as demonstrated by decreasing neurosphere formation and cancer stem cell marker protein expression;Additionally for two genes that are deregulated in PCa heterogeneous nuclear ribonucleoprotein K hnRNP-K and vascular endothelial growth factor A VEGF-A we identified two regulatory miRNAs miR-205 and miR-29b ; glioblastoma;prostate cancer hsa-miR-335-5p VEGFA -2.09515619961552 1.03765771499548e-25 3.1902151031465 4.32161998112301e-60 miRNAWalker2_validate -0.560731405851007 4.75077750352693e-23 NA NA NA hsa-miR-362-3p VEGFA -0.753214251798232 3.0025661608035e-07 3.1902151031465 4.32161998112301e-60 miRanda -0.478977237100648 5.87028343678109e-08 NA NA NA hsa-miR-429 VEGFA -2.16569233119434 2.66862243626443e-37 3.1902151031465 4.32161998112301e-60 MirTarget;miRanda;miRNATAP -0.567681641585143 1.7112668371199e-18 NA NA NA hsa-miR-9-5p VEGFA -2.23538606210968 1.28143998950751e-12 3.1902151031465 4.32161998112301e-60 miRNAWalker2_validate -0.222102357667036 1.24335781156383e-08 NA NA NA hsa-miR-125a-5p VEGFB -0.561874059994802 7.3931856356891e-13 0.889287998012356 1.57204399120492e-27 miRanda -0.312191565292049 2.15759355844345e-07 NA NA NA