miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-215-5p DTL -1.35643065897947 2.3180023440257e-20 3.09524931018974 3.38561149701948e-88 miRNAWalker2_validate -0.148925642754857 0.000176235908348768 21752725;20433742 miR-215 is a tumor suppressor candidate due to the upregulation of p53 and p21 by targeting DTL; However high levels of miR-215 conferred chemoresistance due to cell cycle arrest and reduced cell proliferation by suppressing DTL; DTL was significantly over-expressed and was inversely correlated with miR-215 further suggesting an in vivo physiologic relevance of miR-215 mediated DTL suppression; Furthermore an elevated expression of a miR-215 target protein DTL was detected in colon cancer tissues whereas no expression was present in normal tissues;Taken together our results indicate that miR-215 through the suppression of DTL expression induces a decreased cell proliferation by causing G2-arrest thereby leading to an increase in chemoresistance to MTX and TDX drug resistance;drug resistance colon cancer;sarcoma hsa-miR-217 DTL -0.616728851115349 8.64977119332241e-05 3.09524931018974 3.38561149701948e-88 miRanda -0.176046595463176 2.95943710149525e-06 NA NA NA hsa-miR-26b-5p DTL -0.331527896896866 0.000551258576575092 3.09524931018974 3.38561149701948e-88 miRNAWalker2_validate -0.196741770311046 0.0015599081779525 NA NA NA hsa-miR-30a-3p DTL -1.08956435286856 1.10750674569595e-12 3.09524931018974 3.38561149701948e-88 MirTarget -0.302284201249489 1.20006702437199e-15 22287560 MiR 30a 5p suppresses tumor growth in colon carcinoma by targeting DTL colon cancer hsa-miR-30a-5p DTL -0.392489994825279 0.00954894667761676 3.09524931018974 3.38561149701948e-88 miRNAWalker2_validate;miRTarBase -0.263313931865653 1.27263604765273e-11 22287560 MiR 30a 5p suppresses tumor growth in colon carcinoma by targeting DTL; Subsequent reporter gene assays confirmed the predicted miR-30a-5p binding site in the 3'untranslated region of DTL; In conclusion our data identified miR-30a-5p as a tumor-suppressing miRNA in colon cancer cells exerting its function via modulation of DTL expression which is frequently overexpressed in colorectal cancer colon cancer hsa-miR-30e-3p DTL -0.708952170420973 1.05866470714978e-22 3.09524931018974 3.38561149701948e-88 MirTarget -0.494800481414055 7.26323781864189e-10 NA NA NA hsa-miR-376c-3p DTL -1.23221625820254 6.08631316990405e-17 3.09524931018974 3.38561149701948e-88 MirTarget -0.332879422166369 2.68135147531776e-17 NA NA NA hsa-miR-495-3p DTL -1.67685437612894 1.70634429769052e-34 3.09524931018974 3.38561149701948e-88 MirTarget -0.412572746128254 4.12349142058006e-24 NA NA NA hsa-miR-664a-3p DTL -0.237699857923843 0.0197071390183375 3.09524931018974 3.38561149701948e-88 mirMAP -0.159092472700392 0.00668882978130705 NA NA NA