miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-182-5p AASS 3.53923166221814 5.07781258121574e-21 -1.35265775661789 5.38870424542386e-05 MirTarget -0.116410968280722 0.00482856243261934 NA NA NA hsa-miR-182-5p AATK 3.53923166221814 5.07781258121574e-21 -0.615969232464073 0.0257068187953113 MirTarget -0.114541191271719 0.000687000071712762 NA NA NA hsa-miR-182-5p ABL2 3.53923166221814 5.07781258121574e-21 -0.318835189302919 0.0455399452105181 mirMAP -0.142041939712293 6.07073497417664e-14 NA NA NA hsa-miR-182-5p ACVR1 3.53923166221814 5.07781258121574e-21 -0.440784615093559 0.011428168867015 MirTarget;miRNATAP -0.149490341775743 6.26318281352499e-13 NA NA NA hsa-miR-182-5p ACVRL1 3.53923166221814 5.07781258121574e-21 -1.24662368776506 2.70751841056871e-07 mirMAP -0.250597831078952 4.17846065343439e-18 NA NA NA hsa-miR-182-5p ADAM19 3.53923166221814 5.07781258121574e-21 -1.06497039316686 0.0189522972551201 miRNATAP -0.533109279002736 4.3570524845528e-24 NA NA NA hsa-miR-182-5p ADAMTS18 3.53923166221814 5.07781258121574e-21 -0.739139156012831 0.145989347823725 miRNATAP -0.216589313631971 0.000481201358820777 NA NA NA hsa-miR-182-5p ADAMTS4 3.53923166221814 5.07781258121574e-21 -2.17338507924301 2.13905891927026e-07 MirTarget -0.424153920938501 2.56296159859027e-17 NA NA NA hsa-miR-182-5p ADCY2 3.53923166221814 5.07781258121574e-21 -3.86571368883929 3.85227988382588e-11 miRNATAP -0.4013870076515 2.8800606809304e-08 NA NA NA hsa-miR-182-5p AFAP1 3.53923166221814 5.07781258121574e-21 -0.984844531728039 0.000121375966999112 mirMAP -0.263227885884499 4.06409424872021e-18 NA NA NA hsa-miR-182-5p AFF2 3.53923166221814 5.07781258121574e-21 -1.7276819820086 0.00201353678950772 mirMAP -0.216440007981155 0.00162093713424406 NA NA NA hsa-miR-182-5p AK5 3.53923166221814 5.07781258121574e-21 -1.17560423676368 0.0324844289646241 MirTarget -0.156469111076832 0.0203724925039315 NA NA NA hsa-miR-182-5p AKAP7 3.53923166221814 5.07781258121574e-21 -1.25860380700641 1.06625080623197e-05 miRNATAP -0.140799993045048 6.12760194588608e-05 NA NA NA hsa-miR-182-5p AMOTL2 3.53923166221814 5.07781258121574e-21 -1.01147657574476 0.000152881926388237 miRNATAP -0.239319000600015 7.17874355436452e-14 NA NA NA hsa-miR-182-5p ANK2 3.53923166221814 5.07781258121574e-21 -4.31721795702785 2.30783903904989e-14 miRNATAP -0.752812509507421 1.6975064517713e-29 NA NA NA hsa-miR-182-5p ANTXR2 3.53923166221814 5.07781258121574e-21 -2.30617470732809 4.54834840057871e-13 miRNATAP -0.451604586914995 2.85870546732696e-34 NA NA NA hsa-miR-182-5p ARHGAP6 3.53923166221814 5.07781258121574e-21 -3.24747805818142 5.3316262029649e-12 MirTarget -0.211814524046265 0.000329386374988928 NA NA NA hsa-miR-182-5p ARHGEF3 3.53923166221814 5.07781258121574e-21 -0.764795563081465 2.81227805578292e-06 MirTarget -0.112347246511755 1.55827549076219e-08 NA NA NA hsa-miR-182-5p ARHGEF4 3.53923166221814 5.07781258121574e-21 -1.4406738881977 0.0130992114003101 mirMAP -0.351544032749552 6.16715691444689e-07 NA NA NA hsa-miR-182-5p ARL4C 3.53923166221814 5.07781258121574e-21 -0.28406295826987 0.335346460301793 miRNATAP -0.190653550412615 8.42712858327153e-08 NA NA NA hsa-miR-182-5p ASAP1 3.53923166221814 5.07781258121574e-21 0.0593314983478699 0.779444757742406 mirMAP -0.108503236524537 2.41415341089199e-05 NA NA NA hsa-miR-182-5p ASB1 3.53923166221814 5.07781258121574e-21 -0.87000981136547 1.63208206880833e-08 mirMAP -0.157277050128226 1.27751629612482e-17 NA NA NA hsa-miR-182-5p ASXL3 3.53923166221814 5.07781258121574e-21 -3.33764959592997 4.422152746114e-10 mirMAP -0.36891952885931 2.24283710572372e-08 NA NA NA hsa-miR-182-5p ATP10A 3.53923166221814 5.07781258121574e-21 -0.811415026703069 0.0374058146431988 mirMAP -0.404007688800077 1.22122911490614e-18 NA NA NA hsa-miR-182-5p ATP10D 3.53923166221814 5.07781258121574e-21 -0.688708018852498 0.010040565207979 MirTarget -0.222395619841383 3.7701551612448e-12 NA NA NA hsa-miR-182-5p ATP2B4 3.53923166221814 5.07781258121574e-21 -1.72037479984404 8.20260471374597e-10 mirMAP -0.289376118275112 7.95199686473916e-18 NA NA NA hsa-miR-182-5p ATP8A1 3.53923166221814 5.07781258121574e-21 -1.47752118217688 7.63290299845151e-05 MirTarget;miRNATAP -0.15882578962994 0.000545688793389147 NA NA NA hsa-miR-182-5p ATXN1 3.53923166221814 5.07781258121574e-21 -1.5104377454496 2.95939614593378e-08 mirMAP;miRNATAP -0.3101824982758 6.56589554898194e-22 NA NA NA hsa-miR-182-5p B3GNT7 3.53923166221814 5.07781258121574e-21 -0.341972826249343 0.376128089610537 mirMAP -0.134677612130579 0.00433938887203324 NA NA NA hsa-miR-182-5p BACE1 3.53923166221814 5.07781258121574e-21 -0.723461241968299 0.00095792938893533 mirMAP -0.225156215179252 3.067794590672e-18 NA NA NA hsa-miR-182-5p BACH2 3.53923166221814 5.07781258121574e-21 -1.52271748612635 0.00133867288726185 MirTarget;mirMAP;miRNATAP -0.441071360909214 6.40756845049909e-15 NA NA NA hsa-miR-182-5p BCL2 3.53923166221814 5.07781258121574e-21 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase;mirMAP -0.179869914139863 2.52267854475577e-07 23936432;26870290 Inhibition of proliferation and induction of autophagy by atorvastatin in PC3 prostate cancer cells correlate with downregulation of Bcl2 and upregulation of miR 182 and p21; Bcl2 and p21 were identified to be potential target genes of miR-182 in PC3 cells;The expression levels of B-cell lymphoma-2 Bcl-2 and microRNA-182 miR-182 were detected using western blot analysis and quantitative reverse transcription-polymerase chain reaction respectively; Mangiferin treatment was also able to significantly reduce Bcl-2 expression levels and enhance miR-182 expression in PC3 cells; Finally it was observed that mangiferin inhibited proliferation and induced apoptosis in PC3 human prostate cancer cells and this effect was correlated with downregulation of Bcl-2 and upregulation of miR-182 ; prostate cancer;B cell lymphoma hsa-miR-182-5p BDNF 3.53923166221814 5.07781258121574e-21 -2.90846311399482 3.32327619207597e-11 MirTarget;miRNATAP -0.304142174368882 2.036484274037e-08 NA NA NA hsa-miR-182-5p BHLHE22 3.53923166221814 5.07781258121574e-21 -1.78085310196095 8.27640345654744e-06 MirTarget;miRNATAP -0.125404173945967 0.0111628165771551 NA NA NA hsa-miR-182-5p BMPER 3.53923166221814 5.07781258121574e-21 -2.37696330630979 7.93036685759152e-08 MirTarget -0.310176404863268 1.06003843170975e-08 NA NA NA hsa-miR-182-5p BMPR1B 3.53923166221814 5.07781258121574e-21 0.0707965297684667 0.914043396353822 MirTarget -0.352429426701482 9.54099393700212e-06 NA NA NA hsa-miR-182-5p BNC2 3.53923166221814 5.07781258121574e-21 -2.95176911794991 3.46014802400024e-09 MirTarget;miRNATAP -0.71776251013895 3.86413735645154e-36 NA NA NA hsa-miR-182-5p BRMS1L 3.53923166221814 5.07781258121574e-21 -0.506070486086406 0.00391457381381874 MirTarget -0.116105153227067 4.38175464384311e-08 NA NA NA hsa-miR-182-5p BTLA 3.53923166221814 5.07781258121574e-21 -1.3093113714544 0.0055885120684256 MirTarget -0.383022346212665 1.4561081231856e-11 NA NA NA hsa-miR-182-5p C15orf52 3.53923166221814 5.07781258121574e-21 -1.1812614690092 0.00259990683553622 mirMAP -0.155715424203129 0.00120712780212423 NA NA NA hsa-miR-182-5p C17orf51 3.53923166221814 5.07781258121574e-21 -0.678914258700408 0.0225411911064938 mirMAP -0.229058546440458 1.48398857874875e-10 NA NA NA hsa-miR-182-5p C1orf21 3.53923166221814 5.07781258121574e-21 -1.50529673423141 7.359521051655e-11 mirMAP -0.136807831463124 1.81284237973681e-06 NA NA NA hsa-miR-182-5p CACNA2D1 3.53923166221814 5.07781258121574e-21 -3.31556565717047 8.68804644381516e-07 miRNATAP -0.802351589400528 3.37596704110403e-24 NA NA NA hsa-miR-182-5p CACNB2 3.53923166221814 5.07781258121574e-21 -2.97276927954599 1.73108973462894e-15 miRNATAP -0.365172476882356 1.60928198337665e-15 NA NA NA hsa-miR-182-5p CACNB4 3.53923166221814 5.07781258121574e-21 -2.87454559120761 1.1475342642129e-10 miRNATAP -0.316604534485063 8.60776206418429e-09 NA NA NA hsa-miR-182-5p CADM1 3.53923166221814 5.07781258121574e-21 -1.1928516537365 0.0125125326037739 miRNATAP -0.138741614978997 0.0180136306085462 24445397 TGF β upregulates miR 182 expression to promote gallbladder cancer metastasis by targeting CADM1; We further identified that the cell adhesion molecule1 CADM1 is a new target gene of miR-182 miR-182 negatively regulates CADM1 expression in vitro and in vivo metastasis bladder cancer hsa-miR-182-5p CADM2 3.53923166221814 5.07781258121574e-21 -3.83563052563186 2.24615008924082e-11 MirTarget;mirMAP;miRNATAP -0.257669129298721 0.000327158089637738 NA NA NA hsa-miR-182-5p CALD1 3.53923166221814 5.07781258121574e-21 -2.4663455628847 1.26294093745705e-11 MirTarget -0.572370021752522 4.34620815049957e-44 NA NA NA hsa-miR-182-5p CBFA2T3 3.53923166221814 5.07781258121574e-21 -1.55556335084053 2.30574321070702e-05 MirTarget;miRNATAP -0.101667349232731 0.0252687373220531 NA NA NA hsa-miR-182-5p CBX6 3.53923166221814 5.07781258121574e-21 -1.53953176885359 2.83932741324751e-07 miRNAWalker2_validate -0.187526276698243 3.46475443847444e-07 NA NA NA hsa-miR-182-5p CCDC88A 3.53923166221814 5.07781258121574e-21 -0.76463960543305 0.0119877409095406 miRNATAP -0.271831447720421 6.56284260787347e-14 NA NA NA hsa-miR-182-5p CCND2 3.53923166221814 5.07781258121574e-21 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.418107303561313 5.83833309647385e-20 NA NA NA hsa-miR-182-5p CD209 3.53923166221814 5.07781258121574e-21 -1.78312650459774 0.000348543978778311 mirMAP -0.63946225835341 7.9320761453835e-29 NA NA NA hsa-miR-182-5p CD226 3.53923166221814 5.07781258121574e-21 -1.60922864485771 0.000254727297606939 MirTarget -0.426275694537129 3.93034272235752e-16 NA NA NA hsa-miR-182-5p CD274 3.53923166221814 5.07781258121574e-21 0.0610119269874347 0.90454084693838 mirMAP -0.315636435163749 2.85172426239732e-07 NA NA NA hsa-miR-182-5p CD47 3.53923166221814 5.07781258121574e-21 -0.164318188512451 0.480797231316326 MirTarget;miRNATAP -0.13449272547477 1.85234112980256e-06 NA NA NA hsa-miR-182-5p CD59 3.53923166221814 5.07781258121574e-21 -0.701153559236412 0.00130409241528683 MirTarget -0.144218246334533 4.83638010283245e-08 NA NA NA hsa-miR-182-5p CDC42BPA 3.53923166221814 5.07781258121574e-21 -1.41193338652648 2.19437213080473e-10 MirTarget;miRNATAP -0.185215897092821 9.30283725574719e-12 NA NA NA hsa-miR-182-5p CDC42EP3 3.53923166221814 5.07781258121574e-21 -1.35474123311743 4.46611463922157e-07 mirMAP -0.250823977657232 7.40811822217889e-15 NA NA NA hsa-miR-182-5p CDK6 3.53923166221814 5.07781258121574e-21 -0.774202349805119 0.064787030605636 mirMAP -0.342809938093979 8.28135113019132e-12 NA NA NA hsa-miR-182-5p CDKN1A 3.53923166221814 5.07781258121574e-21 -1.29236263370998 3.21238784768704e-06 miRNAWalker2_validate -0.109364926293111 0.00141758512280426 NA NA NA hsa-miR-182-5p CDKN2C 3.53923166221814 5.07781258121574e-21 0.22688212352847 0.433133415352322 MirTarget -0.132415467904401 0.00017052034340074 NA NA NA hsa-miR-182-5p CDV3 3.53923166221814 5.07781258121574e-21 -0.422762901340256 0.00210317952393349 MirTarget;miRNATAP -0.125154689954442 1.76580464983971e-14 NA NA NA hsa-miR-182-5p CECR1 3.53923166221814 5.07781258121574e-21 -0.680299587123653 0.0577716541397693 mirMAP -0.154858152293302 0.000402939138056666 NA NA NA hsa-miR-182-5p CELF2 3.53923166221814 5.07781258121574e-21 -3.04719737979328 4.72041352009215e-15 mirMAP;miRNATAP -0.543435870286861 9.24306112718155e-33 NA NA NA hsa-miR-182-5p CHL1 3.53923166221814 5.07781258121574e-21 -2.42464081478466 0.000427906865227034 MirTarget;miRNATAP -0.305780373755428 0.000295276463094988 24971532 miR 182 targets CHL1 and controls tumor growth and invasion in papillary thyroid carcinoma; Bioinformatics analysis revealed close homolog of LI CHL1 as a potential target of miR-182; Upregulation of miR-182 was significantly correlated with CHL1 downregulation in human PTC tissues and cell lines; miR-182 suppressed the expression of CHL1 mRNA through direct targeting of the 3'-untranslated region 3'-UTR; Silencing of CHL1 counteracted the effects of miR-182 suppression while its overexpression mimicked these effects; Our data collectively indicate that miR-182 in PTC promotes cell proliferation and invasion through direct suppression of CHL1 supporting the potential utility of miR-182 inhibition as a novel therapeutic strategy against PTC thyroid cancer hsa-miR-182-5p CHST10 3.53923166221814 5.07781258121574e-21 -0.673810565184832 0.061091789048812 miRNATAP -0.157440715530544 0.000336285052753459 NA NA NA hsa-miR-182-5p CHST11 3.53923166221814 5.07781258121574e-21 0.53998313547079 0.231103989518921 miRNATAP -0.366804749952682 1.01801990444519e-11 NA NA NA hsa-miR-182-5p CLIC5 3.53923166221814 5.07781258121574e-21 -1.43632340622029 0.000563963531312954 miRNATAP -0.308329255813556 9.21561654884992e-10 NA NA NA hsa-miR-182-5p CLUAP1 3.53923166221814 5.07781258121574e-21 -0.818407818826761 2.60272053307672e-05 miRNATAP -0.118969545991895 5.38555541537669e-07 NA NA NA hsa-miR-182-5p CNN3 3.53923166221814 5.07781258121574e-21 -0.662842637540786 0.00534632089235666 MirTarget -0.156220005087751 5.86829555505636e-08 NA NA NA hsa-miR-182-5p CNTN1 3.53923166221814 5.07781258121574e-21 -4.98280431564283 1.02293078354206e-09 MirTarget;miRNATAP -0.868496511609559 6.7236399661984e-19 NA NA NA hsa-miR-182-5p COL4A4 3.53923166221814 5.07781258121574e-21 -2.67173783661591 1.38931523312633e-08 MirTarget -0.362520040793316 2.96679913995388e-10 NA NA NA hsa-miR-182-5p CORO1C 3.53923166221814 5.07781258121574e-21 -1.12142787999647 2.05016310243217e-07 MirTarget;miRNATAP -0.302054427538835 1.70433982710935e-34 NA NA NA hsa-miR-182-5p CPEB1 3.53923166221814 5.07781258121574e-21 -4.6814370281438 4.97746958394883e-18 miRNATAP -0.748121290214591 1.90908303930684e-31 NA NA NA hsa-miR-182-5p CREB3L1 3.53923166221814 5.07781258121574e-21 -1.81228769825907 2.53797773630782e-05 MirTarget -0.390694636450428 3.73594300120646e-14 NA NA NA hsa-miR-182-5p CREB5 3.53923166221814 5.07781258121574e-21 -2.27679484644664 4.56595042875634e-09 mirMAP -0.464348743181962 3.89829884732289e-24 NA NA NA hsa-miR-182-5p CRISPLD2 3.53923166221814 5.07781258121574e-21 -2.53383239481451 2.94527993191503e-12 mirMAP -0.420716933719727 3.17110637104215e-22 NA NA NA hsa-miR-182-5p CSMD2 3.53923166221814 5.07781258121574e-21 0.911378035710038 0.0161997994935285 mirMAP -0.221047758970605 1.58407801737189e-06 NA NA NA hsa-miR-182-5p CYLD 3.53923166221814 5.07781258121574e-21 -0.892927493541401 1.56901081849426e-07 miRNAWalker2_validate;miRTarBase;miRNATAP -0.170088683970184 6.08932858594753e-17 27476169 We then demonstrated that knockdown of miR-182 up-regulated the expression of cylindromatosis CYLD deubiquitinase which promoted the formation of death-inducing signaling complex DISC and subsequent caspase-8 activation in TNF-α-treated BT-549 cells breast cancer hsa-miR-182-5p DAAM2 3.53923166221814 5.07781258121574e-21 -2.22700754971104 2.14986647076169e-10 mirMAP -0.375542841324343 4.32635099356557e-19 NA NA NA hsa-miR-182-5p DACT1 3.53923166221814 5.07781258121574e-21 -1.78085143314576 2.05886005067419e-05 MirTarget -0.429298253756581 5.43121387900343e-18 NA NA NA hsa-miR-182-5p DENND5B 3.53923166221814 5.07781258121574e-21 -1.35091655519941 9.63273930805463e-05 MirTarget;miRNATAP -0.327441318585945 2.38277083089333e-15 NA NA NA hsa-miR-182-5p DLG2 3.53923166221814 5.07781258121574e-21 -3.79723748090986 3.01897311382045e-14 miRNATAP -0.201897965137628 0.00137018119218625 NA NA NA hsa-miR-182-5p DPF3 3.53923166221814 5.07781258121574e-21 -1.66550931035639 8.31086463953742e-06 mirMAP -0.431626067604928 7.45952356366223e-23 NA NA NA hsa-miR-182-5p DTNA 3.53923166221814 5.07781258121574e-21 -4.06049121456747 1.59577306327407e-12 mirMAP -0.70899234440676 2.7123730955996e-25 NA NA NA hsa-miR-182-5p DUSP3 3.53923166221814 5.07781258121574e-21 -1.04472877082381 6.16231013810421e-12 mirMAP -0.216653786785627 3.30809852131513e-35 NA NA NA hsa-miR-182-5p DYNC1I1 3.53923166221814 5.07781258121574e-21 -2.0457299899893 0.00010088277927843 MirTarget -0.226263406387141 0.00046986586021078 NA NA NA hsa-miR-182-5p EBF1 3.53923166221814 5.07781258121574e-21 -2.88717194498131 2.67899786981751e-17 miRNATAP -0.418661867559774 2.33526428009822e-24 NA NA NA hsa-miR-182-5p EBF3 3.53923166221814 5.07781258121574e-21 -2.2154309523513 7.17493999444255e-11 MirTarget;miRNATAP -0.267781580131297 1.4094740368998e-10 NA NA NA hsa-miR-182-5p EDIL3 3.53923166221814 5.07781258121574e-21 -1.39552344263701 0.00540706010756216 MirTarget -0.292534452921023 1.64376711255295e-06 NA NA NA hsa-miR-182-5p EDNRB 3.53923166221814 5.07781258121574e-21 -2.52310122132934 4.0560560911117e-12 miRNATAP -0.224875799672555 6.74022156516521e-07 NA NA NA hsa-miR-182-5p EGR3 3.53923166221814 5.07781258121574e-21 -4.24788771954966 5.33225463207111e-21 MirTarget -0.520382869375895 6.38382912516321e-21 NA NA NA hsa-miR-182-5p EIF4E3 3.53923166221814 5.07781258121574e-21 -1.31017825340346 4.2763514565159e-09 mirMAP -0.109852630478514 7.08751162784412e-05 NA NA NA hsa-miR-182-5p EIF5A2 3.53923166221814 5.07781258121574e-21 -1.11920105116458 0.00497256140729196 mirMAP -0.348723735470338 2.39890488592298e-13 NA NA NA hsa-miR-182-5p ELL2 3.53923166221814 5.07781258121574e-21 -1.08408930026814 1.18240618311454e-05 MirTarget;miRNATAP -0.198755696588226 3.0017898489984e-11 NA NA NA hsa-miR-182-5p ELMO1 3.53923166221814 5.07781258121574e-21 -1.21325599380361 5.90368839878061e-05 MirTarget -0.302192286678394 3.78745340124829e-17 NA NA NA hsa-miR-182-5p ENTPD1 3.53923166221814 5.07781258121574e-21 -1.12219223948292 8.05257550730918e-10 mirMAP -0.263639157673808 1.39285542490782e-36 NA NA NA hsa-miR-182-5p EOMES 3.53923166221814 5.07781258121574e-21 -0.654957790276543 0.194942063904072 MirTarget -0.335333862627768 3.85814037105648e-08 NA NA NA hsa-miR-182-5p EPDR1 3.53923166221814 5.07781258121574e-21 -1.64105947206782 0.000351189669955332 MirTarget -0.467703509776766 7.95807935607664e-18 NA NA NA hsa-miR-182-5p EPHA3 3.53923166221814 5.07781258121574e-21 -3.17995997634921 4.72542752542387e-15 miRNATAP -0.431286004950732 2.49229724892096e-18 NA NA NA hsa-miR-182-5p EPHA7 3.53923166221814 5.07781258121574e-21 -4.20206952913252 6.81894380739864e-12 miRNATAP -0.29396608789893 0.000124733367785231 NA NA NA hsa-miR-182-5p EPHB1 3.53923166221814 5.07781258121574e-21 -2.06632027088443 2.47699644252697e-06 MirTarget;miRNATAP -0.410556792921227 6.28130511261273e-15 NA NA NA hsa-miR-182-5p EPM2A 3.53923166221814 5.07781258121574e-21 -1.90233116870269 9.7764279872753e-23 miRNATAP -0.249093578477933 3.54663551481616e-26 NA NA NA hsa-miR-182-5p EPYC 3.53923166221814 5.07781258121574e-21 2.07054590791174 0.00523441030120972 MirTarget -0.361268428255123 6.69395876322745e-05 NA NA NA hsa-miR-182-5p ERG 3.53923166221814 5.07781258121574e-21 -1.3479378771967 2.23511589174121e-07 mirMAP -0.265659700435345 1.23871055142559e-17 NA NA NA hsa-miR-182-5p F13A1 3.53923166221814 5.07781258121574e-21 -2.67071497938806 3.96595860370351e-08 miRNATAP -0.601065983867808 4.93385294443841e-26 NA NA NA hsa-miR-182-5p FAM107A 3.53923166221814 5.07781258121574e-21 -5.00865420988181 1.32570913157414e-25 MirTarget -0.48069501601445 1.62563326105348e-15 NA NA NA hsa-miR-182-5p FAM124A 3.53923166221814 5.07781258121574e-21 -2.08623099443114 7.5264221195319e-08 mirMAP -0.465320749200241 1.80974399107619e-24 NA NA NA hsa-miR-182-5p FAM134B 3.53923166221814 5.07781258121574e-21 -1.39144367060901 0.000674691585504748 MirTarget;miRNATAP -0.192257182959281 0.000125934036509417 NA NA NA hsa-miR-182-5p FAM167A 3.53923166221814 5.07781258121574e-21 0.270294509636431 0.487790761066615 miRNATAP -0.166982558413956 0.000436377054515616 NA NA NA hsa-miR-182-5p FAM168A 3.53923166221814 5.07781258121574e-21 -0.715878355157019 0.0048087062534339 MirTarget -0.160066800352122 2.00399723557489e-07 NA NA NA hsa-miR-182-5p FAM171A1 3.53923166221814 5.07781258121574e-21 -1.60197929634559 3.82982438832311e-05 miRNATAP -0.20273194111507 2.15209502835312e-05 NA NA NA hsa-miR-182-5p FAM26E 3.53923166221814 5.07781258121574e-21 -1.51380317009881 3.60338715627852e-05 mirMAP -0.433334920586435 4.22036744913742e-24 NA NA NA hsa-miR-182-5p FAM78A 3.53923166221814 5.07781258121574e-21 -0.17566660865732 0.571673572062009 MirTarget;miRNATAP -0.270873057434249 2.2191718026889e-13 NA NA NA hsa-miR-182-5p FAT3 3.53923166221814 5.07781258121574e-21 -2.79096679677476 3.40343867448209e-06 mirMAP -0.306222864244541 3.46821363548968e-05 NA NA NA hsa-miR-182-5p FBN1 3.53923166221814 5.07781258121574e-21 -1.81792584376713 5.27450945120085e-05 miRNATAP -0.54842784532456 9.57298560258998e-26 NA NA NA hsa-miR-182-5p FBXO32 3.53923166221814 5.07781258121574e-21 -0.934956145489406 0.00122406817472722 mirMAP -0.369929085845502 8.47824880204894e-29 NA NA NA hsa-miR-182-5p FER 3.53923166221814 5.07781258121574e-21 -0.960481943610693 0.000174638463493531 mirMAP -0.209315630731097 1.07463141602378e-11 NA NA NA hsa-miR-182-5p FGF9 3.53923166221814 5.07781258121574e-21 -4.26095125698269 8.03301928631002e-16 miRTarBase;miRNATAP -0.199763187583912 0.00291090860779188 NA NA NA hsa-miR-182-5p FMNL3 3.53923166221814 5.07781258121574e-21 0.138843294816209 0.460998322398368 miRNAWalker2_validate -0.15138267969285 1.61677869872247e-11 NA NA NA hsa-miR-182-5p FMO2 3.53923166221814 5.07781258121574e-21 -2.4057104016729 0.000137336354224179 MirTarget -0.648038684375853 4.46002914986829e-18 NA NA NA hsa-miR-182-5p FOXN3 3.53923166221814 5.07781258121574e-21 -1.43525991184281 2.70084540955391e-16 MirTarget;miRNATAP -0.153361540385543 1.51312923712541e-12 NA NA NA hsa-miR-182-5p FOXO1 3.53923166221814 5.07781258121574e-21 -1.06087355985292 3.97103810866528e-08 miRNAWalker2_validate;miRTarBase;miRNATAP -0.128361006344551 5.90064794890719e-08 24865442;26640590;23313739 Immunohistochemical analysis revealed that the levels of FOXO1 and FOXO3A two potential miR-182 targets are reduced in AA tumors;MiR 182 Is Associated with Growth Migration and Invasion in Prostate Cancer via Suppression of FOXO1; Our findings suggest that miR-182 may act to increase prostate cancer proliferation migration and invasion through suppression of FOXO1;Western blot flow cytometry and pathway analysis for the HeLa cells with miR-182 over/down-expression in vitro showed that miR-182 was involved in apoptosis and cell cycle pathways it also associated with the regulation of FOXO1 ;; colon cancer;prostate cancer;cervical and endocervical cancer hsa-miR-182-5p FOXP2 3.53923166221814 5.07781258121574e-21 -3.99353205302265 7.58170962329672e-11 miRNATAP -0.530829204108895 1.44997951932681e-12 NA NA NA hsa-miR-182-5p FYCO1 3.53923166221814 5.07781258121574e-21 -1.6226100593392 1.01871130782658e-16 miRNATAP -0.183561710505323 2.57227652800677e-14 NA NA NA hsa-miR-182-5p GAS7 3.53923166221814 5.07781258121574e-21 -2.67478964713793 6.70176551418169e-10 mirMAP -0.555065937334407 7.61011737566646e-28 NA NA NA hsa-miR-182-5p GCNT1 3.53923166221814 5.07781258121574e-21 0.0413031024334329 0.927473803129616 miRNATAP -0.273519857361614 6.25930709920995e-07 NA NA NA hsa-miR-182-5p GFOD1 3.53923166221814 5.07781258121574e-21 -0.940659645129877 0.00660758228917747 mirMAP -0.330905123891382 8.14364631945609e-16 NA NA NA hsa-miR-182-5p GIMAP1 3.53923166221814 5.07781258121574e-21 -1.23982274736301 6.11362537330939e-05 MirTarget -0.366718897096619 2.85143062383144e-24 NA NA NA hsa-miR-182-5p GJC1 3.53923166221814 5.07781258121574e-21 -0.972020676723743 0.00222017431601357 mirMAP -0.238173714559401 5.12686240176862e-10 NA NA NA hsa-miR-182-5p GLB1L 3.53923166221814 5.07781258121574e-21 -0.510508251671836 0.00564583070620466 MirTarget -0.135263992363863 1.11702019282309e-09 NA NA NA hsa-miR-182-5p GLI2 3.53923166221814 5.07781258121574e-21 -2.28902662613598 1.9678941791174e-06 MirTarget -0.513578930610023 2.39073152531938e-19 NA NA NA hsa-miR-182-5p GNG7 3.53923166221814 5.07781258121574e-21 -3.47904747202308 1.83990532659951e-21 mirMAP -0.33394588120831 3.25159373659616e-13 NA NA NA hsa-miR-182-5p GPR132 3.53923166221814 5.07781258121574e-21 -0.613688306043001 0.105694101529907 mirMAP -0.339176089989011 5.48889659247046e-14 NA NA NA hsa-miR-182-5p GPR183 3.53923166221814 5.07781258121574e-21 -2.34009544763103 5.97806938169407e-08 MirTarget -0.512234038448543 6.99577505702738e-24 NA NA NA hsa-miR-182-5p GPR3 3.53923166221814 5.07781258121574e-21 -0.959139062474991 0.000525741080276061 mirMAP -0.125103884553983 0.00022380431523227 NA NA NA hsa-miR-182-5p GPRASP2 3.53923166221814 5.07781258121574e-21 -1.4590659609289 3.45285620607504e-12 miRNATAP -0.199120059000491 5.96955483259228e-15 NA NA NA hsa-miR-182-5p GRIA3 3.53923166221814 5.07781258121574e-21 -2.06852702129128 7.47403992493886e-05 miRNATAP -0.448657144405691 9.05518728953662e-13 NA NA NA hsa-miR-182-5p GRID1 3.53923166221814 5.07781258121574e-21 -0.61772636758298 0.168665600534068 miRNATAP -0.19410121664038 0.000391239108098855 NA NA NA hsa-miR-182-5p GRIN2A 3.53923166221814 5.07781258121574e-21 -3.3233994538381 1.07825857067501e-08 mirMAP -0.433021080719212 1.17139439458597e-09 NA NA NA hsa-miR-182-5p GRIN3A 3.53923166221814 5.07781258121574e-21 -0.237867214305963 0.403188120647802 mirMAP -0.202175653573079 3.42067073886148e-09 NA NA NA hsa-miR-182-5p GXYLT2 3.53923166221814 5.07781258121574e-21 -1.72430339748435 0.00323225716692418 MirTarget -0.684651014234304 9.40082569277235e-24 NA NA NA hsa-miR-182-5p HBEGF 3.53923166221814 5.07781258121574e-21 -2.25664314425713 3.15709120593558e-11 MirTarget;miRNATAP -0.254157460078064 1.29310759383123e-09 NA NA NA hsa-miR-182-5p HDAC9 3.53923166221814 5.07781258121574e-21 -1.51871944408113 0.000720912761325448 miRNATAP -0.394470161664077 2.21525501148198e-13 26858310 HDAC Inhibition Induces MicroRNA 182 which Targets RAD51 and Impairs HR Repair to Sensitize Cells to Sapacitabine in Acute Myelogenous Leukemia; HR reporter assays apoptotic assays and colony-forming assays established that the miR-182 as well as the HDAC inhibition-mediated decreases in RAD51 inhibited HR repair and sensitized cells to sapacitabine; HDAC inhibition induced miR-182 in AML cell lines and primary AML blasts; Overexpression of miR-182 as well as HDAC inhibition-mediated induction of miR-182 were linked to time- and dose-dependent decreases in the levels of RAD51 an inhibition of HR increased levels of residual damage and decreased survival after exposure to double-strand damage-inducing agents; Our findings define the mechanism by which HDAC inhibition induces miR-182 to target RAD51 and highlights a novel pharmacologic strategy that compromises the ability of AML cells to conduct HR thereby sensitizing AML cells to DNA-damaging agents that activate HR as a repair and potential resistance mechanism poor survival;drug resistance acute myeloid leukemia hsa-miR-182-5p HIF3A 3.53923166221814 5.07781258121574e-21 -4.97932860856302 1.68517995562999e-14 mirMAP -0.59511946392683 8.93512712702467e-14 NA NA NA hsa-miR-182-5p HLA-DOA 3.53923166221814 5.07781258121574e-21 -0.788750104329619 0.0786620965309561 mirMAP -0.360017176205859 2.06197244488985e-11 NA NA NA hsa-miR-182-5p HMCN1 3.53923166221814 5.07781258121574e-21 -0.313432950411344 0.472274244820938 MirTarget -0.327137144574447 4.04828665487044e-10 NA NA NA hsa-miR-182-5p HOXA9 3.53923166221814 5.07781258121574e-21 -0.997610561961181 0.0549612762571718 miRNATAP -0.147586331187047 0.0206098194128181 NA NA NA hsa-miR-182-5p HSPA13 3.53923166221814 5.07781258121574e-21 -0.287922247159853 0.106347732939114 miRNATAP -0.104782630734016 1.18093143745574e-06 NA NA NA hsa-miR-182-5p IGSF10 3.53923166221814 5.07781258121574e-21 -5.30237641574688 9.03000767899905e-16 MirTarget -0.548815603409051 2.06756334138691e-11 NA NA NA hsa-miR-182-5p IKZF1 3.53923166221814 5.07781258121574e-21 -1.30628932919626 0.00159566603720278 mirMAP -0.370913669378994 6.21105504306128e-14 NA NA NA hsa-miR-182-5p IL16 3.53923166221814 5.07781258121574e-21 -1.47099849326459 3.21424073431104e-07 mirMAP -0.308512240000045 1.83759901101031e-19 NA NA NA hsa-miR-182-5p IL17RD 3.53923166221814 5.07781258121574e-21 -1.40831642994976 1.59383539640135e-05 mirMAP -0.22992015538285 6.93949859285865e-09 NA NA NA hsa-miR-182-5p IL6R 3.53923166221814 5.07781258121574e-21 -1.86576803083567 2.67166891084766e-06 mirMAP -0.308185867210701 1.67894161264071e-10 NA NA NA hsa-miR-182-5p IL6ST 3.53923166221814 5.07781258121574e-21 -2.09967019941458 1.93264814611531e-05 mirMAP -0.422787250881008 9.05725280154988e-13 NA NA NA hsa-miR-182-5p ISL1 3.53923166221814 5.07781258121574e-21 -2.91478963644857 6.12434734425048e-07 miRNATAP -0.263851805774181 0.000259709731523561 NA NA NA hsa-miR-182-5p ITGB8 3.53923166221814 5.07781258121574e-21 -0.771536596399464 0.078204531928335 MirTarget -0.165583568981071 0.00199407237884609 NA NA NA hsa-miR-182-5p ITPKB 3.53923166221814 5.07781258121574e-21 -1.70322432049595 4.43562078746451e-23 mirMAP -0.20631782230461 1.44085297075041e-22 NA NA NA hsa-miR-182-5p ITPR1 3.53923166221814 5.07781258121574e-21 -2.58213364075087 3.81753054779227e-18 miRNATAP -0.33429215603713 3.095472024721e-20 NA NA NA hsa-miR-182-5p JAKMIP3 3.53923166221814 5.07781258121574e-21 -2.48258063839244 3.80905318276763e-07 mirMAP -0.249054585102042 3.64338838498772e-05 NA NA NA hsa-miR-182-5p JAZF1 3.53923166221814 5.07781258121574e-21 -1.91995536790338 5.72076669427973e-12 MirTarget;miRNATAP -0.44522846180329 8.6791146417435e-46 NA NA NA hsa-miR-182-5p KCNJ12 3.53923166221814 5.07781258121574e-21 -2.26039929904991 2.90659346174232e-05 mirMAP -0.525005939768965 4.02395563370181e-16 NA NA NA hsa-miR-182-5p KCNJ2 3.53923166221814 5.07781258121574e-21 -0.281197518883409 0.36164514317052 miRNATAP -0.12619777379892 0.000786381028917242 NA NA NA hsa-miR-182-5p KCNQ5 3.53923166221814 5.07781258121574e-21 -3.67132504069307 1.90545533023382e-08 MirTarget -0.750744259911725 2.81882910264077e-22 NA NA NA hsa-miR-182-5p KDELC2 3.53923166221814 5.07781258121574e-21 -0.714539871567231 0.00145605854632104 MirTarget -0.177736731117618 4.49975398766198e-11 NA NA NA hsa-miR-182-5p KIAA1614 3.53923166221814 5.07781258121574e-21 -2.0146471536211 8.95131044809253e-13 mirMAP -0.39513550046192 1.77030235977227e-33 NA NA NA hsa-miR-182-5p KIAA2022 3.53923166221814 5.07781258121574e-21 -3.77781848258777 1.47825574429182e-12 miRNATAP -0.465350238388983 1.2232402502756e-12 NA NA NA hsa-miR-182-5p KIF19 3.53923166221814 5.07781258121574e-21 -2.22066031589261 1.60470538162673e-06 miRNATAP -0.39502852039163 1.62890561073816e-12 NA NA NA hsa-miR-182-5p KLF13 3.53923166221814 5.07781258121574e-21 -1.16141618366409 1.36372480238947e-05 MirTarget;miRNATAP -0.233345907627747 3.64889470487799e-13 NA NA NA hsa-miR-182-5p KLF7 3.53923166221814 5.07781258121574e-21 -0.396294178926278 0.170315776862033 MirTarget;miRNATAP -0.233347685936262 1.44917283942083e-11 NA NA NA hsa-miR-182-5p KLHL21 3.53923166221814 5.07781258121574e-21 -1.03680560428652 2.27490455113544e-07 mirMAP -0.172723849646445 9.58616530167698e-13 NA NA NA hsa-miR-182-5p KLHL4 3.53923166221814 5.07781258121574e-21 -2.04246744229493 0.00019958548677145 mirMAP -0.699431454969273 2.35111111967904e-28 NA NA NA hsa-miR-182-5p KPNA3 3.53923166221814 5.07781258121574e-21 -0.573359539342796 0.00262291748998806 MirTarget;miRNATAP -0.11168030244929 1.40482121370394e-06 NA NA NA hsa-miR-182-5p L1CAM 3.53923166221814 5.07781258121574e-21 -2.88244045420262 0.000237271593415049 MirTarget;miRNATAP -0.66799098737671 1.35697034079145e-12 NA NA NA hsa-miR-182-5p LAMC1 3.53923166221814 5.07781258121574e-21 -0.820359806292778 9.59613230767155e-05 miRNATAP -0.208617431877303 6.51660327570966e-17 NA NA NA hsa-miR-182-5p LIFR 3.53923166221814 5.07781258121574e-21 -2.63259527057529 1.38063075823569e-10 mirMAP -0.391394043860235 3.5767895328356e-15 NA NA NA hsa-miR-182-5p LIMS1 3.53923166221814 5.07781258121574e-21 -0.388381349388172 0.148139138497081 MirTarget;miRNATAP -0.116923567741085 0.000354221880553294 NA NA NA hsa-miR-182-5p LITAF 3.53923166221814 5.07781258121574e-21 -0.788929754767639 4.35306874197171e-05 MirTarget -0.155036090097895 2.65388234598928e-11 NA NA NA hsa-miR-182-5p LMOD1 3.53923166221814 5.07781258121574e-21 -4.98176884690939 5.21861914982847e-20 miRNATAP -0.789596210332783 1.09736087877131e-34 NA NA NA hsa-miR-182-5p LONRF2 3.53923166221814 5.07781258121574e-21 -3.8642101573018 7.90463940348435e-08 mirMAP -0.279876426960886 0.00173497697525483 NA NA NA hsa-miR-182-5p LPP 3.53923166221814 5.07781258121574e-21 -2.04092311415528 2.98839088727532e-15 MirTarget;miRNATAP -0.299012668479955 8.77736152999015e-22 NA NA NA hsa-miR-182-5p LRCH1 3.53923166221814 5.07781258121574e-21 -1.09367192084794 2.38111166969073e-11 MirTarget -0.184150427873521 4.18434560193655e-21 NA NA NA hsa-miR-182-5p LRCH2 3.53923166221814 5.07781258121574e-21 -2.83984975921435 2.14431508265196e-12 miRNATAP -0.445530377039467 5.12864424755453e-20 NA NA NA hsa-miR-182-5p LRP12 3.53923166221814 5.07781258121574e-21 -0.228599612770888 0.447188912695946 MirTarget -0.13880065071528 0.000149005246700917 NA NA NA hsa-miR-182-5p LRRC7 3.53923166221814 5.07781258121574e-21 -3.91787209255121 5.73746646820421e-15 MirTarget -0.316597493453036 4.75999125017864e-07 NA NA NA hsa-miR-182-5p MAF 3.53923166221814 5.07781258121574e-21 -1.28341922239874 0.00015825213662883 mirMAP;miRNATAP -0.353056657270293 1.56006706060078e-18 NA NA NA hsa-miR-182-5p MAFB 3.53923166221814 5.07781258121574e-21 -0.0500082844783902 0.882833918895083 mirMAP -0.276773306487276 8.37949462096353e-12 NA NA NA hsa-miR-182-5p MAGEL2 3.53923166221814 5.07781258121574e-21 -0.804281326553108 0.108198332126092 miRNATAP -0.14923986857643 0.0149809744777445 NA NA NA hsa-miR-182-5p MAN1A1 3.53923166221814 5.07781258121574e-21 -1.19565908364499 0.000880972558098608 MirTarget -0.157167235720871 0.000362309528154577 NA NA NA hsa-miR-182-5p MAP1A 3.53923166221814 5.07781258121574e-21 -2.81936532211288 1.95093328905874e-14 miRNATAP -0.534492901738045 7.54394576647017e-36 NA NA NA hsa-miR-182-5p MAP1B 3.53923166221814 5.07781258121574e-21 -3.18358434812783 4.83606017602339e-16 MirTarget;mirMAP;miRNATAP -0.549821540766757 8.3578263652054e-33 NA NA NA hsa-miR-182-5p MAP3K3 3.53923166221814 5.07781258121574e-21 -0.867302315651695 4.69975718275905e-09 miRNATAP -0.192247148692721 4.9074620442185e-29 NA NA NA hsa-miR-182-5p MAP4K4 3.53923166221814 5.07781258121574e-21 0.130872521838526 0.522814141079271 MirTarget -0.104709849442277 2.49586396666125e-05 NA NA NA hsa-miR-182-5p MCFD2 3.53923166221814 5.07781258121574e-21 -0.273710952309139 0.0802130111446696 mirMAP -0.104983020204128 2.47013607649832e-08 NA NA NA hsa-miR-182-5p MDGA1 3.53923166221814 5.07781258121574e-21 -1.00154386684221 0.0303398006837731 mirMAP -0.392671602299597 1.20084967093431e-12 NA NA NA hsa-miR-182-5p MEF2C 3.53923166221814 5.07781258121574e-21 -2.13436808535659 1.07833769123274e-14 MirTarget;miRNATAP -0.364343251860128 6.0726616709347e-29 NA NA NA hsa-miR-182-5p MEF2D 3.53923166221814 5.07781258121574e-21 -1.254473345286 3.30937184393369e-26 miRNATAP -0.171263944894999 1.54261479458554e-33 NA NA NA hsa-miR-182-5p MITF 3.53923166221814 5.07781258121574e-21 -2.11043666647908 2.14681139044162e-09 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.459685004473695 4.82335519155237e-29 19188590 In human tissues expression of miR-182 increases with progression from primary to metastatic melanoma and inversely correlates with FOXO3 and microphthalmia-associated transcription factor levels progression melanoma hsa-miR-182-5p MMD 3.53923166221814 5.07781258121574e-21 -0.0500962943374854 0.870546787744501 miRNATAP -0.235201708813205 1.68472873711789e-10 NA NA NA hsa-miR-182-5p MPP1 3.53923166221814 5.07781258121574e-21 -1.1646568248169 0.00139878541621182 miRNATAP -0.432923626680806 1.5988332386929e-24 NA NA NA hsa-miR-182-5p MRAS 3.53923166221814 5.07781258121574e-21 -1.30047814978706 1.21141012267765e-05 miRNATAP -0.350262585535789 7.07903170837591e-24 NA NA NA hsa-miR-182-5p MSN 3.53923166221814 5.07781258121574e-21 -0.85546319996218 0.0136615174636227 MirTarget -0.399550800387866 4.11732098452187e-23 NA NA NA hsa-miR-182-5p MYADM 3.53923166221814 5.07781258121574e-21 -2.82656540386901 8.49316181730987e-14 miRNATAP -0.512418905082231 1.04439196115464e-30 NA NA NA hsa-miR-182-5p MYO1E 3.53923166221814 5.07781258121574e-21 -0.243672932340454 0.248294329644903 mirMAP -0.111921593247605 1.2288284930221e-05 NA NA NA hsa-miR-182-5p MYOCD 3.53923166221814 5.07781258121574e-21 -5.66084293327068 2.02112506902108e-19 miRNATAP -0.723268982644115 4.47157933208955e-21 NA NA NA hsa-miR-182-5p NAMPT 3.53923166221814 5.07781258121574e-21 -1.01188888675403 7.98621574991513e-05 miRNATAP -0.150739445918225 1.4842347242114e-06 NA NA NA hsa-miR-182-5p NAV1 3.53923166221814 5.07781258121574e-21 -0.418200324441875 0.108742163308665 mirMAP -0.162499440053465 2.55093539261836e-07 NA NA NA hsa-miR-182-5p NCALD 3.53923166221814 5.07781258121574e-21 -2.321244587023 7.09583257149169e-15 miRNATAP -0.319688853781737 1.08863841581343e-18 NA NA NA hsa-miR-182-5p NCAM1 3.53923166221814 5.07781258121574e-21 -5.46812766536887 2.35522582039703e-18 miRNATAP -0.880539440508718 1.24572785948416e-32 NA NA NA hsa-miR-182-5p NCS1 3.53923166221814 5.07781258121574e-21 -1.7356703955299 3.35229307090603e-12 mirMAP -0.275068806780465 4.04979192928314e-20 NA NA NA hsa-miR-182-5p NECAB1 3.53923166221814 5.07781258121574e-21 -3.26252425353249 2.74412248921453e-12 MirTarget -0.573738700410589 3.87613007739481e-25 NA NA NA hsa-miR-182-5p NFASC 3.53923166221814 5.07781258121574e-21 -2.95717922837883 4.31475260476481e-14 mirMAP;miRNATAP -0.355661514772188 1.46622088784593e-13 NA NA NA hsa-miR-182-5p NFATC2 3.53923166221814 5.07781258121574e-21 -2.09940213646525 2.77134949511158e-05 mirMAP -0.274974364845855 7.50815876894642e-06 NA NA NA hsa-miR-182-5p NFE2L1 3.53923166221814 5.07781258121574e-21 -0.171483758009488 0.176829520001656 mirMAP -0.100221563463628 3.4665178436214e-11 NA NA NA hsa-miR-182-5p NID1 3.53923166221814 5.07781258121574e-21 -0.986451929862748 0.00102953096063708 MirTarget -0.295454065439856 1.14089924295907e-16 NA NA NA hsa-miR-182-5p NLGN2 3.53923166221814 5.07781258121574e-21 -0.461039789162801 0.0537634389723614 miRNATAP -0.105498397867137 0.000295122792234236 NA NA NA hsa-miR-182-5p NOX4 3.53923166221814 5.07781258121574e-21 1.1573407399002 0.00254007513014407 miRNATAP -0.244352134211728 1.52467264829522e-07 NA NA NA hsa-miR-182-5p NPTX1 3.53923166221814 5.07781258121574e-21 -3.0548528465665 5.58655593069716e-09 miRNATAP -0.203865005867158 0.00178465104632102 NA NA NA hsa-miR-182-5p NR3C1 3.53923166221814 5.07781258121574e-21 -1.29490546417786 3.89055618845506e-05 miRNATAP -0.348761530594502 4.72913170211402e-21 NA NA NA hsa-miR-182-5p NTM 3.53923166221814 5.07781258121574e-21 -0.0757758455544759 0.858274223904391 miRTarBase -0.219419953630614 2.06309065493846e-05 NA NA NA hsa-miR-182-5p NTNG1 3.53923166221814 5.07781258121574e-21 -4.11654002819262 1.71914221059989e-10 MirTarget -0.681059239341281 1.52555929579791e-18 NA NA NA hsa-miR-182-5p NTRK2 3.53923166221814 5.07781258121574e-21 -3.4444884279512 9.02401971614574e-08 mirMAP -0.542854638305866 3.89545557204651e-12 NA NA NA hsa-miR-182-5p NTRK3 3.53923166221814 5.07781258121574e-21 -5.17034960965042 5.23662623079398e-21 mirMAP -0.494727844384687 7.13881547217231e-13 NA NA NA hsa-miR-182-5p NUAK1 3.53923166221814 5.07781258121574e-21 0.329626043944068 0.281541076624495 MirTarget;miRNATAP -0.167269623337841 6.64789694611871e-06 NA NA NA hsa-miR-182-5p OOEP 3.53923166221814 5.07781258121574e-21 0.328110667201719 0.553202985043231 MirTarget -0.140272597093182 0.0384819359406382 NA NA NA hsa-miR-182-5p OPTN 3.53923166221814 5.07781258121574e-21 -0.238930465886824 0.283287504085888 MirTarget -0.171441225698603 1.26913598993335e-10 NA NA NA hsa-miR-182-5p PALLD 3.53923166221814 5.07781258121574e-21 -2.68837995750497 4.71973205022663e-15 MirTarget;miRNATAP -0.563766379986888 4.12381429318305e-48 NA NA NA hsa-miR-182-5p PAPPA 3.53923166221814 5.07781258121574e-21 -1.75955305841573 0.000134461135734203 MirTarget -0.341287001136072 9.68224374928512e-10 NA NA NA hsa-miR-182-5p PARM1 3.53923166221814 5.07781258121574e-21 -2.48542985552476 1.81540274264961e-10 MirTarget;miRNATAP -0.180368453367043 0.000206057096908734 NA NA NA hsa-miR-182-5p PAX6 3.53923166221814 5.07781258121574e-21 -0.0440427707484987 0.892699851474819 miRNATAP -0.106752555564538 0.00745383766555968 NA NA NA hsa-miR-182-5p PCDH10 3.53923166221814 5.07781258121574e-21 -3.23750023602778 3.50143209305191e-07 miRNATAP -0.517297538557891 2.02609152641839e-11 NA NA NA hsa-miR-182-5p PCDH17 3.53923166221814 5.07781258121574e-21 -0.31543828817169 0.277167062556602 miRNATAP -0.134867977002453 0.000134758176343061 NA NA NA hsa-miR-182-5p PCDH18 3.53923166221814 5.07781258121574e-21 -2.10799539281951 6.39285767196275e-11 MirTarget;miRNATAP -0.347131710517165 3.14739625192111e-19 NA NA NA hsa-miR-182-5p PCGF5 3.53923166221814 5.07781258121574e-21 -0.764423238295416 4.61130231454902e-07 miRNATAP -0.109016944750503 3.409035389269e-09 NA NA NA hsa-miR-182-5p PCOLCE2 3.53923166221814 5.07781258121574e-21 -4.92842826125534 3.75529487642829e-16 miRNAWalker2_validate -0.73624117085977 4.47098337633947e-24 NA NA NA hsa-miR-182-5p PDE1C 3.53923166221814 5.07781258121574e-21 -4.13701966391324 7.08661414779568e-16 mirMAP -0.60650560010366 1.00390501634832e-22 NA NA NA hsa-miR-182-5p PDE4D 3.53923166221814 5.07781258121574e-21 -2.16999194209536 1.89831164898157e-16 mirMAP -0.286053226995175 5.39367018882014e-19 NA NA NA hsa-miR-182-5p PDGFRA 3.53923166221814 5.07781258121574e-21 -2.37640583073564 1.39737819859365e-09 miRNATAP -0.375439590705967 2.48477058044486e-15 NA NA NA hsa-miR-182-5p PDPN 3.53923166221814 5.07781258121574e-21 -0.844865171556352 0.0581255733752544 MirTarget -0.343824754183795 1.3413236189011e-10 NA NA NA hsa-miR-182-5p PDZD4 3.53923166221814 5.07781258121574e-21 -3.50328419678476 5.69234493908284e-16 MirTarget;miRNATAP -0.404982921371749 3.18212888055154e-14 NA NA NA hsa-miR-182-5p PDZRN4 3.53923166221814 5.07781258121574e-21 -5.72101367483932 1.28426115579874e-16 miRNATAP -0.839726981433761 6.48190184990179e-24 NA NA NA hsa-miR-182-5p PHF19 3.53923166221814 5.07781258121574e-21 -0.569884194868888 0.0249085385065336 mirMAP -0.23503758353394 6.55264581197105e-15 NA NA NA hsa-miR-182-5p PHLDB1 3.53923166221814 5.07781258121574e-21 -0.688909556015726 0.00122355801941463 miRNATAP -0.193171316714041 2.84255608640527e-14 NA NA NA hsa-miR-182-5p PHYHIPL 3.53923166221814 5.07781258121574e-21 -1.3403818845059 0.020958999472695 miRNATAP -0.180920145746829 0.0110876182594979 NA NA NA hsa-miR-182-5p PIK3AP1 3.53923166221814 5.07781258121574e-21 -0.459059440376337 0.265936020481245 MirTarget -0.391785355726999 9.99609004314833e-16 NA NA NA hsa-miR-182-5p PIK3R5 3.53923166221814 5.07781258121574e-21 -0.990769658200862 0.00792713202187119 MirTarget -0.391730270801049 4.50362857100536e-19 NA NA NA hsa-miR-182-5p PLEKHH2 3.53923166221814 5.07781258121574e-21 -1.66246097253843 1.34981296620878e-06 MirTarget -0.232899423303958 3.01091844657952e-08 NA NA NA hsa-miR-182-5p PLOD2 3.53923166221814 5.07781258121574e-21 0.408783051727277 0.223517816964063 miRNATAP -0.264029735377106 5.17442693519629e-11 NA NA NA hsa-miR-182-5p PLXDC1 3.53923166221814 5.07781258121574e-21 0.00175712757885371 0.994886591921339 mirMAP -0.194459916449649 3.58734524047039e-09 NA NA NA hsa-miR-182-5p PLXNA4 3.53923166221814 5.07781258121574e-21 -2.25456361904941 4.96438419774251e-05 mirMAP -0.677276740478778 1.08010079860403e-25 NA NA NA hsa-miR-182-5p POU2F2 3.53923166221814 5.07781258121574e-21 -1.67646318583251 4.09542292476508e-07 miRNATAP -0.34801693236366 1.01767234142359e-18 NA NA NA hsa-miR-182-5p PPM1F 3.53923166221814 5.07781258121574e-21 -0.484267586694392 0.00139346420727647 MirTarget -0.127375934410954 2.03781885237881e-12 NA NA NA hsa-miR-182-5p PPP1R12A 3.53923166221814 5.07781258121574e-21 -1.33746384858456 3.3695937531748e-17 miRNATAP -0.190892950904658 1.53363916370312e-23 NA NA NA hsa-miR-182-5p PPP1R12B 3.53923166221814 5.07781258121574e-21 -3.46376452255787 1.1364412732345e-26 mirMAP -0.46153021585297 5.51358822046675e-32 NA NA NA hsa-miR-182-5p PRDM1 3.53923166221814 5.07781258121574e-21 -0.799773282697487 0.0106840144209139 miRNATAP -0.149673383161081 9.06896532328256e-05 NA NA NA hsa-miR-182-5p PRDM16 3.53923166221814 5.07781258121574e-21 -2.56004666228196 1.1360029849919e-06 mirMAP;miRNATAP -0.248249655306067 0.000131448197070304 NA NA NA hsa-miR-182-5p PRICKLE2 3.53923166221814 5.07781258121574e-21 -2.50492561876767 7.67759900282699e-16 MirTarget -0.402997008407211 1.15936336737611e-27 NA NA NA hsa-miR-182-5p PRKAA2 3.53923166221814 5.07781258121574e-21 -3.1651157275578 4.06046613880045e-09 miRNAWalker2_validate;MirTarget;mirMAP -0.331706760870251 5.94483360132956e-07 NA NA NA hsa-miR-182-5p PRKACB 3.53923166221814 5.07781258121574e-21 -1.11910356116881 7.24897707751757e-07 MirTarget;miRNATAP -0.141282769334308 3.27226662914892e-07 NA NA NA hsa-miR-182-5p PRKAR2A 3.53923166221814 5.07781258121574e-21 -0.958058230501873 0.00166358416501506 mirMAP -0.15304190547009 3.93441644995187e-05 NA NA NA hsa-miR-182-5p PRKD1 3.53923166221814 5.07781258121574e-21 -1.53164811371414 4.119038025094e-05 miRNATAP -0.210338416290666 4.21468202836352e-06 NA NA NA hsa-miR-182-5p PRRG1 3.53923166221814 5.07781258121574e-21 -0.464304628644506 0.115609951928287 mirMAP -0.153574374175986 1.84995631885687e-05 NA NA NA hsa-miR-182-5p PRUNE2 3.53923166221814 5.07781258121574e-21 -4.80598803189319 1.66841624992026e-13 miRNATAP -0.96625211517253 7.53487864798096e-38 NA NA NA hsa-miR-182-5p PRX 3.53923166221814 5.07781258121574e-21 -1.40075382104523 1.17274413921886e-10 mirMAP -0.160775002420511 1.8047978567658e-09 NA NA NA hsa-miR-182-5p PTGER3 3.53923166221814 5.07781258121574e-21 -3.17892614473001 1.0932904794636e-07 miRNATAP -0.637016336152709 4.19821656682483e-19 NA NA NA hsa-miR-182-5p PTGFR 3.53923166221814 5.07781258121574e-21 -4.31417785205749 1.80615933126723e-13 MirTarget -0.774702010804082 3.21951695927932e-29 NA NA NA hsa-miR-182-5p PTHLH 3.53923166221814 5.07781258121574e-21 -0.637337427958821 0.359541326845111 MirTarget -0.410558056926388 1.10216659777992e-06 NA NA NA hsa-miR-182-5p PTP4A1 3.53923166221814 5.07781258121574e-21 -0.886199664882353 4.27122299209568e-05 miRNATAP -0.118531023202364 7.66767324737065e-06 NA NA NA hsa-miR-182-5p PTPRG 3.53923166221814 5.07781258121574e-21 -0.659570164498502 0.0398812996716316 MirTarget;miRNATAP -0.1963272444908 4.46053310509134e-07 NA NA NA hsa-miR-182-5p QKI 3.53923166221814 5.07781258121574e-21 -0.459712923996318 0.00440824124371165 mirMAP -0.135684485978041 1.98353534000198e-12 NA NA NA hsa-miR-182-5p RAB11FIP5 3.53923166221814 5.07781258121574e-21 -0.275218903695492 0.0980214449037859 miRNATAP -0.110448541717746 3.51864717565856e-08 NA NA NA hsa-miR-182-5p RAB31 3.53923166221814 5.07781258121574e-21 -0.565488704793941 0.0757768686383417 mirMAP -0.369144048511619 1.62312647501591e-23 NA NA NA hsa-miR-182-5p RAB34 3.53923166221814 5.07781258121574e-21 -0.536697359666198 0.10714948591148 miRNATAP -0.169333471179939 2.92497307970239e-05 NA NA NA hsa-miR-182-5p RAPGEF5 3.53923166221814 5.07781258121574e-21 -0.580986175597244 0.0366906480299328 MirTarget -0.164378855734397 1.09181602237902e-06 NA NA NA hsa-miR-182-5p RASGRF2 3.53923166221814 5.07781258121574e-21 -0.959101466033611 0.00295453490406439 mirMAP -0.280032478581552 3.94983090544796e-13 NA NA NA hsa-miR-182-5p RBPMS 3.53923166221814 5.07781258121574e-21 -1.76986611936615 2.10521492077454e-10 mirMAP -0.163253875178284 2.26950968720443e-06 NA NA NA hsa-miR-182-5p RDX 3.53923166221814 5.07781258121574e-21 -0.333782953922244 0.221635333144355 MirTarget;miRNATAP -0.114580993744112 0.000578440056629381 NA NA NA hsa-miR-182-5p RECK 3.53923166221814 5.07781258121574e-21 -2.38610578026315 7.82688892259109e-14 miRNAWalker2_validate;miRNATAP -0.401952252290376 3.00734108680527e-26 23226455;27648365;23333633 We also identified Smad4 and RECK as potential target genes of miR-182-5p using several algorithms; In conclusion our data suggests that miR-182-5p plays an important role as an oncogene by knocking down RECK and Smad4 resulting in activation of the Wnt-beta-catenin signaling pathway in bladder cancer;In our previous results we demonstrated that miR-182 was over-expressed in breast cancer cell lines and clinical tumor tissues and its up-regulation increased tumorigenicity and invasiveness by repressing a tumor suppressor RECK;Up regulation of miR 182 by β catenin in breast cancer increases tumorigenicity and invasiveness by targeting the matrix metalloproteinase inhibitor RECK; The correlation between miR-182 and RECK was analyzed by Western blotting real-time RT-PCR and 3'-untranslated region reporter assay; Ectopic expression of miR-182 inhibited restoration of RECK protein by β-catenin inhibitor indicating miR-182 is important for β-catenin-induced down-regulation of RECK; An inverse association between miR-182 and RECK was demonstrated in breast tumor tissues; We provide evidence that miR-182 is up-regulated by β-catenin signaling pathway in breast cancer and its up-regulation increases tumorigenicity and invasiveness by repressing RECK; In addition we identify a new miR-182 target RECK which is important for miR-182-induced tumorigenesis ;;tumorigenesis bladder cancer;breast cancer;breast cancer hsa-miR-182-5p REEP1 3.53923166221814 5.07781258121574e-21 -4.34753961523252 3.78306600846853e-15 miRNATAP -0.568011258020081 4.05621459049462e-17 NA NA NA hsa-miR-182-5p RELL1 3.53923166221814 5.07781258121574e-21 -0.699510059379432 0.000153337737223854 MirTarget -0.132276452334424 3.30154061700793e-09 NA NA NA hsa-miR-182-5p RFTN1 3.53923166221814 5.07781258121574e-21 -0.515091372232221 0.0525029974344917 miRNATAP -0.23800735443647 4.86374952090027e-14 NA NA NA hsa-miR-182-5p RGL1 3.53923166221814 5.07781258121574e-21 -1.51925487686695 6.14848968356696e-09 MirTarget -0.280987384646267 2.05586290564071e-19 NA NA NA hsa-miR-182-5p RGS5 3.53923166221814 5.07781258121574e-21 -2.66173182333744 1.67220114552801e-13 MirTarget -0.237763498939591 1.25758549604338e-07 NA NA NA hsa-miR-182-5p RIMBP2 3.53923166221814 5.07781258121574e-21 -2.69405047193145 5.63343241147361e-07 mirMAP;miRNATAP -0.297999288979254 6.93851875827488e-06 NA NA NA hsa-miR-182-5p RIMS3 3.53923166221814 5.07781258121574e-21 -1.42027619315578 3.00440701262036e-05 MirTarget;miRNATAP -0.196768199322744 2.29735746598719e-06 NA NA NA hsa-miR-182-5p RIN3 3.53923166221814 5.07781258121574e-21 -0.542708773196135 0.0113680652033468 mirMAP -0.240740455203217 5.81028498606835e-22 NA NA NA hsa-miR-182-5p RNF212 3.53923166221814 5.07781258121574e-21 -2.78983710949886 1.11878098033565e-08 MirTarget -0.381270058210798 1.66237576886054e-10 NA NA NA hsa-miR-182-5p RNF217 3.53923166221814 5.07781258121574e-21 -1.13715450185669 0.0097437081213251 mirMAP -0.362563869680168 6.16119274692539e-12 NA NA NA hsa-miR-182-5p ROCK1 3.53923166221814 5.07781258121574e-21 -1.02661670614902 1.94754524728051e-09 MirTarget -0.129367164013929 6.18056517206253e-10 NA NA NA hsa-miR-182-5p RRAGD 3.53923166221814 5.07781258121574e-21 -1.28210533175691 5.97051882858326e-05 mirMAP -0.226125984810836 5.51093347185599e-09 NA NA NA hsa-miR-182-5p RUNDC3B 3.53923166221814 5.07781258121574e-21 -2.34766072113968 4.25783257641366e-15 miRNATAP -0.209140456565893 2.15275397383635e-08 NA NA NA hsa-miR-182-5p RUNX1T1 3.53923166221814 5.07781258121574e-21 -3.29112409449622 2.69681218718585e-11 mirMAP -0.540180397526602 8.27196285329787e-20 NA NA NA hsa-miR-182-5p SAMD4A 3.53923166221814 5.07781258121574e-21 -2.17607774370782 7.9670339471712e-12 MirTarget;miRNATAP -0.431739952671371 2.74467874432483e-31 NA NA NA hsa-miR-182-5p SCN2A 3.53923166221814 5.07781258121574e-21 -1.29167455183038 0.0301757402573598 miRNATAP -0.341078549639938 2.46746883642958e-06 NA NA NA hsa-miR-182-5p SCN3A 3.53923166221814 5.07781258121574e-21 -2.32699009748223 7.40591172107087e-07 miRNATAP -0.313753294912719 4.91119771804196e-08 NA NA NA hsa-miR-182-5p SCN4B 3.53923166221814 5.07781258121574e-21 -2.75295017691825 5.60438848890772e-15 mirMAP -0.259760998997352 3.26788989818682e-09 NA NA NA hsa-miR-182-5p SCN9A 3.53923166221814 5.07781258121574e-21 -1.38434426315237 0.00934391039271171 mirMAP;miRNATAP -0.251482434683206 0.000111171555446994 NA NA NA hsa-miR-182-5p SCRN1 3.53923166221814 5.07781258121574e-21 -0.564649180285022 0.0489255478589769 mirMAP -0.201328269103519 5.677477095992e-09 NA NA NA hsa-miR-182-5p SCUBE3 3.53923166221814 5.07781258121574e-21 -2.48127471582544 2.66234551923326e-07 miRNATAP -0.366193976989197 4.60952345680499e-10 NA NA NA hsa-miR-182-5p SDC2 3.53923166221814 5.07781258121574e-21 -2.00706478458987 1.28300608152733e-09 miRNATAP -0.329370187889486 1.36307943900447e-16 NA NA NA hsa-miR-182-5p SETBP1 3.53923166221814 5.07781258121574e-21 -2.26227903514797 8.87237114441678e-09 mirMAP -0.350919867085126 1.85601162847403e-13 NA NA NA hsa-miR-182-5p SETD7 3.53923166221814 5.07781258121574e-21 -1.13463057726458 1.78342966519954e-10 MirTarget;miRNATAP -0.213594347414529 2.79528304630975e-24 NA NA NA hsa-miR-182-5p SETX 3.53923166221814 5.07781258121574e-21 -0.708007818270648 2.86307552568454e-08 MirTarget;miRNATAP -0.110128178390888 8.56347378784709e-13 NA NA NA hsa-miR-182-5p SFRP1 3.53923166221814 5.07781258121574e-21 -4.72165743596444 1.94213340952985e-11 mirMAP -0.689760445961909 6.52748321080623e-16 NA NA NA hsa-miR-182-5p SGCB 3.53923166221814 5.07781258121574e-21 -1.44760592804974 4.88730706418823e-10 mirMAP -0.327112075589339 2.52618191762848e-34 NA NA NA hsa-miR-182-5p SGMS2 3.53923166221814 5.07781258121574e-21 -1.36680165019397 1.86579437284973e-05 MirTarget;miRNATAP -0.343609876146844 8.54441599087068e-20 NA NA NA hsa-miR-182-5p SH2D1A 3.53923166221814 5.07781258121574e-21 -1.10597424227522 0.0293424555172639 MirTarget;miRNATAP -0.372541578671597 1.10440891703557e-09 NA NA NA hsa-miR-182-5p SH3BGRL 3.53923166221814 5.07781258121574e-21 -1.43100123895073 2.53257963935967e-09 MirTarget -0.220896460763939 2.94731576682063e-14 NA NA NA hsa-miR-182-5p SH3PXD2A 3.53923166221814 5.07781258121574e-21 -0.987155493438988 1.02406192375196e-05 mirMAP -0.172318606957502 2.01025496675354e-10 NA NA NA hsa-miR-182-5p SH3PXD2B 3.53923166221814 5.07781258121574e-21 -0.53998931418926 0.0139175585788792 miRNATAP -0.182566396150399 3.55002717830252e-12 NA NA NA hsa-miR-182-5p SH3RF3 3.53923166221814 5.07781258121574e-21 -1.68472949721979 5.44492695285492e-08 MirTarget -0.375845225006747 4.84341397806321e-25 NA NA NA hsa-miR-182-5p SHC4 3.53923166221814 5.07781258121574e-21 -0.664061852285107 0.0809797980708126 MirTarget;miRNATAP -0.221370731435305 1.61837528879945e-06 NA NA NA hsa-miR-182-5p SHROOM3 3.53923166221814 5.07781258121574e-21 -1.26167822754868 0.000636872985591942 mirMAP -0.193814049611371 1.76856078260864e-05 NA NA NA hsa-miR-182-5p SIK2 3.53923166221814 5.07781258121574e-21 -0.895905910195029 1.03810013473188e-10 mirMAP -0.118140205275128 2.57240219798893e-12 NA NA NA hsa-miR-182-5p SLC1A2 3.53923166221814 5.07781258121574e-21 -1.63926856184029 0.00011983867188635 MirTarget;miRNATAP -0.167826996575068 0.00137551386193892 NA NA NA hsa-miR-182-5p SLC2A3 3.53923166221814 5.07781258121574e-21 -2.09454232135098 3.92772896271437e-08 MirTarget -0.383138056908853 5.19460392670154e-17 NA NA NA hsa-miR-182-5p SLC6A17 3.53923166221814 5.07781258121574e-21 0.941104200796897 0.0568131902197341 mirMAP -0.288512156747641 1.4954201161374e-06 NA NA NA hsa-miR-182-5p SLC7A2 3.53923166221814 5.07781258121574e-21 -1.40305887660435 0.00128606407427126 mirMAP -0.114482246955911 0.0329630048458994 NA NA NA hsa-miR-182-5p SLCO2B1 3.53923166221814 5.07781258121574e-21 -0.857147486993845 0.0465370602382169 MirTarget -0.511094330687764 1.13131700683799e-24 NA NA NA hsa-miR-182-5p SLCO3A1 3.53923166221814 5.07781258121574e-21 -0.349114583112527 0.300053914964445 MirTarget;miRNATAP -0.15105445912022 0.000232143455879123 NA NA NA hsa-miR-182-5p SLITRK4 3.53923166221814 5.07781258121574e-21 -2.22318009296394 0.000124335481622699 MirTarget;miRNATAP -0.490211833525425 2.00715993704635e-12 NA NA NA hsa-miR-182-5p SMAD7 3.53923166221814 5.07781258121574e-21 -1.18986730797292 6.37278457783496e-08 miRNATAP -0.139835996687329 2.24704056840338e-07 NA NA NA hsa-miR-182-5p SNAI2 3.53923166221814 5.07781258121574e-21 -0.280307189347724 0.489884936104145 miRNAWalker2_validate;miRNATAP -0.226684880391696 4.11330558077327e-06 NA NA NA hsa-miR-182-5p SNX29 3.53923166221814 5.07781258121574e-21 -0.637224583441126 6.77957051876116e-05 mirMAP -0.129045948935314 2.00024745426939e-11 NA NA NA hsa-miR-182-5p SOX5 3.53923166221814 5.07781258121574e-21 -2.80899915084138 3.69546336813367e-12 miRNATAP -0.339154870096328 8.52822195836199e-12 NA NA NA hsa-miR-182-5p SOX6 3.53923166221814 5.07781258121574e-21 -2.16170894059309 7.49520430040923e-06 miRNATAP -0.194005093120807 0.00112779147110448 NA NA NA hsa-miR-182-5p ST3GAL3 3.53923166221814 5.07781258121574e-21 -1.09370616658902 5.68245266413635e-09 mirMAP -0.165846014156959 3.02448155461591e-13 NA NA NA hsa-miR-182-5p ST6GALNAC3 3.53923166221814 5.07781258121574e-21 -2.04578308207892 3.03442932816697e-11 mirMAP -0.249758834218924 3.81951869242818e-11 NA NA NA hsa-miR-182-5p STARD13 3.53923166221814 5.07781258121574e-21 -2.17932975894295 1.5776545031728e-14 miRNATAP -0.411832828424052 6.82114383675963e-36 NA NA NA hsa-miR-182-5p STAT1 3.53923166221814 5.07781258121574e-21 0.542663454678779 0.0737713250641883 mirMAP -0.163334442311918 9.45184839156753e-06 NA NA NA hsa-miR-182-5p STC1 3.53923166221814 5.07781258121574e-21 -1.55340441030689 1.29077994156941e-05 miRNATAP -0.230472760529581 1.14762757177164e-07 NA NA NA hsa-miR-182-5p STK17A 3.53923166221814 5.07781258121574e-21 -0.23852001224455 0.313522804067474 miRNATAP -0.155317324198671 5.21647695556427e-08 NA NA NA hsa-miR-182-5p STK17B 3.53923166221814 5.07781258121574e-21 -0.462761081076055 0.0431834704534941 miRNATAP -0.155278454825387 1.85901716321481e-08 NA NA NA hsa-miR-182-5p STX1B 3.53923166221814 5.07781258121574e-21 -0.831193288425681 0.0477395804955152 mirMAP -0.336363473190289 2.30693227072617e-11 NA NA NA hsa-miR-182-5p STXBP6 3.53923166221814 5.07781258121574e-21 -3.29735555779228 1.4741858431786e-07 mirMAP -0.313518905989811 5.26414006289328e-05 NA NA NA hsa-miR-182-5p SV2B 3.53923166221814 5.07781258121574e-21 -2.33341367960543 7.07116491599061e-05 mirMAP -0.573035878584313 2.59940915410328e-16 NA NA NA hsa-miR-182-5p TACC1 3.53923166221814 5.07781258121574e-21 -1.71010964840655 3.78195172257726e-09 MirTarget;miRNATAP -0.171376503186908 1.74200234186493e-06 NA NA NA hsa-miR-182-5p TAF4B 3.53923166221814 5.07781258121574e-21 -0.440551340182907 0.163919692677726 MirTarget;miRNATAP -0.122866264441996 0.00147563792485391 NA NA NA hsa-miR-182-5p TCEAL7 3.53923166221814 5.07781258121574e-21 -3.24676947087228 8.59713834221883e-18 MirTarget -0.408241484672296 1.10534399715066e-18 24021963 The purpose of this study was to examine the role of microRNA-182 and its target gene transcription elongation factor A-like 7 TCEAL7 in EC; The expression of miR-182 in human normal endometrial epithelial cells NEEC and in three human endometrial carcinoma cell lines HEC-1B RL95-2 and AN3CA was measured by qRT-PCR and the mRNA and protein expression of TCEAL7 were assessed in the same three endometrial carcinoma cell lines and NEEC by qRT-PCR and western blotting respectively; MiR-182 was significantly upregulated and TCEAL7 was downregulated in EC cell lines compared to NEEC endometrial cancer hsa-miR-182-5p TEAD1 3.53923166221814 5.07781258121574e-21 -1.49495998391161 1.96516757915294e-13 mirMAP;miRNATAP -0.208311227035654 3.08897671904962e-17 NA NA NA hsa-miR-182-5p THBS1 3.53923166221814 5.07781258121574e-21 -2.1277814514878 2.63898598170147e-08 MirTarget -0.464276709680251 4.8914160255443e-25 24053448 Effects of anti miR 182 on TSP 1 expression in human colon cancer cells: there is a sense in antisense?; We investigate on the molecular mechanism by which miR-182 could regulate thrombospondin-1 TSP-1 expression a protein downregulated in CRC and inversely correlated with tumor vascularity and metastasis; miR-182 over-expressed in colorectal cancer CRC has like predictive target thrombospondin-1 TSP-1 a protein inversely correlated with tumor vascularity and metastasis that results downregulated in different types of cancer including CRC; We found that TSP-1 increased after transfection with anti-miR-182 and we showed that miR-182 targets TSP-1 3'UTR-mRNA in both cells; Our data suggest that miR-182 targets the anti-angiogenic factor TSP-1 and that anti-miR-182 determines an upregulation of TSP-1 expression in colon cancer cells metastasis colon cancer hsa-miR-182-5p THBS2 3.53923166221814 5.07781258121574e-21 -0.819009338080235 0.127001426128545 MirTarget;miRNATAP -0.378179542663928 4.95986922868172e-09 NA NA NA hsa-miR-182-5p THSD4 3.53923166221814 5.07781258121574e-21 -2.37339687749734 3.92006931404185e-13 mirMAP -0.235937697536687 6.00156640627385e-09 NA NA NA hsa-miR-182-5p TIFAB 3.53923166221814 5.07781258121574e-21 -0.380124172219658 0.461018639505915 mirMAP -0.334006738668731 8.10090185176446e-08 NA NA NA hsa-miR-182-5p TIMP2 3.53923166221814 5.07781258121574e-21 -1.7485334269093 7.3578966378154e-06 mirMAP -0.444158047245332 3.52992744010483e-22 NA NA NA hsa-miR-182-5p TLN1 3.53923166221814 5.07781258121574e-21 -1.45515106009239 3.18740725534339e-16 miRNATAP -0.286157450117998 2.44934212067043e-45 NA NA NA hsa-miR-182-5p TLN2 3.53923166221814 5.07781258121574e-21 -1.13678695432202 2.37164982459728e-06 mirMAP -0.15378766220221 1.7721581252092e-07 NA NA NA hsa-miR-182-5p TMCC3 3.53923166221814 5.07781258121574e-21 -1.35239851980287 4.93606931842352e-05 mirMAP -0.371835305521499 2.27555513424795e-21 NA NA NA hsa-miR-182-5p TMEM108 3.53923166221814 5.07781258121574e-21 -2.78114300571125 1.45650573276381e-06 mirMAP -0.554421072700645 1.13520993786654e-15 NA NA NA hsa-miR-182-5p TMEM150C 3.53923166221814 5.07781258121574e-21 -1.68081227435943 2.1859051388924e-06 MirTarget -0.182640281609837 2.90186439730772e-05 NA NA NA hsa-miR-182-5p TMEM169 3.53923166221814 5.07781258121574e-21 0.212722927647041 0.605338323475114 miRNATAP -0.16170586583927 0.0012840904702696 NA NA NA hsa-miR-182-5p TMEM47 3.53923166221814 5.07781258121574e-21 -1.46523064388337 0.00016547778482874 MirTarget;miRNATAP -0.135358715260602 0.00473071168334015 NA NA NA hsa-miR-182-5p TMOD1 3.53923166221814 5.07781258121574e-21 -2.50806400410317 3.77309071816302e-19 miRNATAP -0.319318365850882 1.15881737281433e-20 NA NA NA hsa-miR-182-5p TNS3 3.53923166221814 5.07781258121574e-21 -0.103104493452801 0.668815191833344 miRNATAP -0.112337177957411 0.000126125264913059 NA NA NA hsa-miR-182-5p TOX 3.53923166221814 5.07781258121574e-21 -2.0322057253246 1.86502526837513e-05 miRNATAP -0.425802778825031 8.13351765474564e-14 NA NA NA hsa-miR-182-5p TP53INP2 3.53923166221814 5.07781258121574e-21 -2.21250190189587 4.52774358230457e-20 MirTarget;miRNATAP -0.156852896630411 2.89825999559286e-07 NA NA NA hsa-miR-182-5p TRAF3 3.53923166221814 5.07781258121574e-21 0.232826128499489 0.140409657391156 mirMAP -0.100497619347189 1.29240740702129e-07 NA NA NA hsa-miR-182-5p TRPM6 3.53923166221814 5.07781258121574e-21 -1.93538766679862 2.33828833032142e-05 MirTarget -0.246711416911322 1.10039461998116e-05 NA NA NA hsa-miR-182-5p TSC22D3 3.53923166221814 5.07781258121574e-21 -1.67435472404316 7.07551770315191e-11 miRNAWalker2_validate;miRNATAP -0.305180456415041 1.27222096476782e-23 NA NA NA hsa-miR-182-5p TSHZ2 3.53923166221814 5.07781258121574e-21 -2.36271880423433 2.34708957144416e-08 miRNATAP -0.307119397948138 3.06959313435153e-09 NA NA NA hsa-miR-182-5p TSPAN11 3.53923166221814 5.07781258121574e-21 -2.3587553580542 3.63548653474133e-10 mirMAP -0.347051550841155 3.0270164105964e-14 NA NA NA hsa-miR-182-5p TSPAN9 3.53923166221814 5.07781258121574e-21 -0.281167092062683 0.142613577594003 MirTarget;miRNATAP -0.113599184378751 9.68036166090994e-07 NA NA NA hsa-miR-182-5p TTBK2 3.53923166221814 5.07781258121574e-21 -1.27061033500643 8.20749802166803e-07 mirMAP -0.156139515435276 7.78480301639662e-07 NA NA NA hsa-miR-182-5p UBE2Q2 3.53923166221814 5.07781258121574e-21 -0.786021468971091 2.04263029736963e-07 MirTarget;miRNATAP -0.106219012806502 8.40657784664679e-09 NA NA NA hsa-miR-182-5p UBR1 3.53923166221814 5.07781258121574e-21 -0.870775603837103 1.62515391893457e-09 mirMAP -0.106588800288203 1.56401780308676e-09 NA NA NA hsa-miR-182-5p UNC5C 3.53923166221814 5.07781258121574e-21 -2.85842438529154 7.1455313233325e-10 mirMAP -0.518965750789195 6.37056810524897e-21 NA NA NA hsa-miR-182-5p VAT1L 3.53923166221814 5.07781258121574e-21 -1.21093342860372 0.00422286393153055 miRNATAP -0.310402604378246 1.22648636436394e-09 NA NA NA hsa-miR-182-5p VCL 3.53923166221814 5.07781258121574e-21 -1.42195933102912 9.04222123827734e-13 miRNATAP -0.250719348001465 1.62430154049536e-26 NA NA NA hsa-miR-182-5p VLDLR 3.53923166221814 5.07781258121574e-21 -1.24679016115614 0.000599286809743815 MirTarget;miRNATAP -0.230979138538618 1.70820982113188e-07 NA NA NA hsa-miR-182-5p WDFY4 3.53923166221814 5.07781258121574e-21 -1.52835958077685 0.00208595788951407 mirMAP -0.514293983627951 1.70350378207187e-18 NA NA NA hsa-miR-182-5p WDR44 3.53923166221814 5.07781258121574e-21 -0.618746968114829 0.00104356284659586 MirTarget -0.123024174487468 7.50288605476641e-08 NA NA NA hsa-miR-182-5p WIPF1 3.53923166221814 5.07781258121574e-21 -1.36396473341553 1.25828143739996e-05 MirTarget;miRNATAP -0.413413248840515 1.07298598160211e-30 NA NA NA hsa-miR-182-5p WISP1 3.53923166221814 5.07781258121574e-21 0.794902972527909 0.129006518215286 MirTarget -0.391982518706977 4.66417906589696e-10 NA NA NA hsa-miR-182-5p WWC2 3.53923166221814 5.07781258121574e-21 -0.762253212847515 0.00511431449708885 MirTarget -0.205285174851598 3.80699465538307e-10 NA NA NA hsa-miR-182-5p ZBTB37 3.53923166221814 5.07781258121574e-21 -0.575470462840692 0.0106071831245277 miRNATAP -0.111712971795685 4.68845729148013e-05 NA NA NA hsa-miR-182-5p ZDHHC14 3.53923166221814 5.07781258121574e-21 -0.420877670161361 0.0714978913519264 mirMAP -0.107611556537821 0.000154777438731494 NA NA NA hsa-miR-182-5p ZFP36L1 3.53923166221814 5.07781258121574e-21 -1.16626499852789 2.6177040079409e-09 miRNATAP -0.128368738757413 9.9958410670594e-08 NA NA NA hsa-miR-182-5p ZMAT3 3.53923166221814 5.07781258121574e-21 -0.834456180454181 0.000338643864818007 mirMAP -0.128544205330595 6.09119797515569e-06 NA NA NA hsa-miR-182-5p ZNF280B 3.53923166221814 5.07781258121574e-21 -1.31579833605866 0.00759832510998532 MirTarget -0.214192781613192 0.000383316797123722 NA NA NA hsa-miR-182-5p ZNF532 3.53923166221814 5.07781258121574e-21 -0.642348594400126 0.00482300004408463 miRNATAP -0.175931129090085 1.3493489891048e-10 NA NA NA