miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-125b-5p AKT1 -1.94393269763542 2.78180543229264e-58 0.675644771423915 4.31393881321574e-23 miRNAWalker2_validate;miRTarBase -0.198341990959858 1.58124486218174e-28 NA NA NA hsa-miR-143-3p AKT1 -1.23248181631499 4.74160976678504e-28 0.675644771423915 4.31393881321574e-23 miRNAWalker2_validate -0.113351907486334 3.74647210660112e-08 NA NA NA hsa-miR-24-3p AKT2 -0.120123317289941 0.21432376743243 -0.0243409112523851 0.696831042278932 mirMAP -0.108581040434418 8.76204903485834e-07 NA NA NA hsa-miR-30e-3p AKT2 -0.708952170420973 1.05866470714978e-22 -0.0243409112523851 0.696831042278932 mirMAP -0.10769217628588 0.000202699653075448 NA NA NA hsa-miR-106b-5p AKT3 1.22477789913175 2.31787213143326e-32 -1.39153139819913 1.56022353185962e-23 miRNATAP -0.328917679851073 3.2761525214021e-13 NA NA NA hsa-miR-107 AKT3 0.678998026350662 2.56224148930538e-16 -1.39153139819913 1.56022353185962e-23 PITA;miRanda -0.322045444014362 3.05085750718847e-08 NA NA NA hsa-miR-15a-5p AKT3 0.812445324157528 4.50263417099822e-20 -1.39153139819913 1.56022353185962e-23 miRNAWalker2_validate;miRTarBase;miRNATAP -0.50537113863267 1.94212195956378e-21 NA NA NA hsa-miR-15b-5p AKT3 0.788659356634696 1.13678211092534e-11 -1.39153139819913 1.56022353185962e-23 miRNATAP -0.193152993862959 3.52162993117826e-06 NA NA NA hsa-miR-16-5p AKT3 0.46835991343556 1.91125356547776e-06 -1.39153139819913 1.56022353185962e-23 miRNAWalker2_validate;miRTarBase;miRNATAP -0.137142128931012 0.00593844300257035 NA NA NA hsa-miR-181a-5p AKT3 0.635863607630183 6.72486918157744e-11 -1.39153139819913 1.56022353185962e-23 miRNATAP -0.151700435123375 0.00241569058552761 NA NA NA hsa-miR-181b-5p AKT3 1.22749257795094 1.21998198830919e-27 -1.39153139819913 1.56022353185962e-23 miRNATAP -0.228362092376509 5.2632904676588e-08 NA NA NA hsa-miR-20a-5p AKT3 0.44979911120222 0.000602386964327228 -1.39153139819913 1.56022353185962e-23 miRNATAP -0.142287905559561 0.000137185408492637 NA NA NA hsa-miR-29b-2-5p AKT3 -0.263499971180298 0.0400001755611965 -1.39153139819913 1.56022353185962e-23 mirMAP -0.174192327083419 4.9828909918003e-06 NA NA NA hsa-miR-29b-3p AKT3 0.438847962603729 6.46722433236121e-05 -1.39153139819913 1.56022353185962e-23 miRNATAP -0.240095261108435 6.25012390753699e-08 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-29c-3p AKT3 -0.0652732378039769 0.563774115756922 -1.39153139819913 1.56022353185962e-23 miRNAWalker2_validate;miRNATAP -0.188130633733952 1.47230271027192e-05 NA NA NA hsa-miR-340-5p AKT3 1.0857159627596 4.94471062546756e-24 -1.39153139819913 1.56022353185962e-23 mirMAP -0.283834227072162 1.26866636163553e-10 NA NA NA hsa-miR-769-5p AKT3 0.564871766265874 8.16695101656941e-10 -1.39153139819913 1.56022353185962e-23 PITA;miRNATAP -0.188201328225218 0.000387633821142586 NA NA NA hsa-miR-93-5p AKT3 1.01788600209314 1.24312921618126e-21 -1.39153139819913 1.56022353185962e-23 miRNATAP -0.358774978428685 5.45504344144073e-16 NA NA NA hsa-miR-146b-5p BRAF 0.631041661167954 6.20366593452965e-08 -0.221283775228288 0.00867803746223788 miRanda -0.110412388583119 7.02387106261161e-06 21874046;26883911;20406109;21537871 Additionally the activation of thyroid most common oncogenes RET/PTC3 and BRAF in PCCL3 cells upregulated miR-146b-5p expression;miR-146b-5p positively regulates migration and invasion of thyroid normal and tumor follicular cells independently from their original mutation either BRAF or RET/PTC through a mechanism that involves the actin cytoskeleton but not an increased capacity of matrix degradation;The miR-146b expression levels in PTCs with BRAF mutation were significantly higher than those without this mutation p < 0.0001;Among BRAF-positive tumors overexpression of miR-146b was associated with aggressive behavior suggesting that it may further refine the prognostic importance of BRAF ;;; thyroid cancer;thyroid cancer;thyroid cancer;thyroid cancer hsa-miR-199a-5p BRAF -0.314703593105081 0.00909304983051124 -0.221283775228288 0.00867803746223788 miRanda -0.11377610292301 1.89244658267459e-06 NA NA NA hsa-miR-199b-5p BRAF -1.37022396448377 3.25758057539223e-26 -0.221283775228288 0.00867803746223788 miRanda -0.103977173726598 1.44472266502555e-06 NA NA NA hsa-miR-103a-3p CAB39 0.610673390034345 1.63113920514646e-12 -0.176243629824704 0.000621544444809565 MirTarget;miRNATAP -0.201253171218925 1.57895319071396e-24 NA NA NA hsa-miR-107 CAB39 0.678998026350662 2.56224148930538e-16 -0.176243629824704 0.000621544444809565 MirTarget;miRanda;miRNATAP -0.163191826347563 3.22494292063296e-15 NA NA NA hsa-miR-15a-5p CAB39 0.812445324157528 4.50263417099822e-20 -0.176243629824704 0.000621544444809565 miRNATAP -0.154971788132432 8.0884516717212e-16 NA NA NA hsa-miR-155-5p CAB39L 1.09766314984151 4.55650930885814e-15 -1.41958178424988 2.17824679172429e-35 miRNAWalker2_validate -0.287890769027545 7.14933176569916e-25 NA NA NA hsa-miR-192-5p CAB39L 1.33366224451777 9.5116159697107e-29 -1.41958178424988 2.17824679172429e-35 miRNAWalker2_validate -0.231501134645787 1.30322836173492e-12 NA NA NA hsa-miR-361-5p CAB39L -0.0996867547900457 0.095428250126326 -1.41958178424988 2.17824679172429e-35 MirTarget;miRanda -0.330966403252337 1.83182973451587e-06 NA NA NA hsa-miR-374a-3p CAB39L 0.34122393953022 2.28714105382856e-05 -1.41958178424988 2.17824679172429e-35 MirTarget -0.156768067476026 0.00210429432001523 NA NA NA hsa-miR-542-3p CAB39L 0.568822103820889 8.5699075257651e-07 -1.41958178424988 2.17824679172429e-35 miRanda -0.121425444114793 0.000573284574798606 NA NA NA hsa-miR-590-3p CAB39L 1.27438512890514 1.03164723481469e-23 -1.41958178424988 2.17824679172429e-35 miRanda -0.29325120657851 6.63397632520721e-20 NA NA NA hsa-miR-590-5p CAB39L 0.746515607868274 8.51300479640125e-09 -1.41958178424988 2.17824679172429e-35 miRanda -0.268274576531643 2.66310373376075e-18 NA NA NA hsa-miR-30a-5p DDIT4 -0.392489994825279 0.00954894667761676 0.602588460594883 3.44966750609546e-05 MirTarget;miRNATAP -0.105191972168508 0.00144674135390842 NA NA NA hsa-miR-30b-5p DDIT4 -0.46540603860146 2.4709940429591e-05 0.602588460594883 3.44966750609546e-05 MirTarget -0.122846576336623 0.00672964517682991 NA NA NA hsa-miR-103a-3p EIF4B 0.610673390034345 1.63113920514646e-12 -0.65019836780356 1.52144443982599e-25 MirTarget;miRNATAP -0.12743739110467 3.76381682109117e-07 NA NA NA hsa-miR-107 EIF4B 0.678998026350662 2.56224148930538e-16 -0.65019836780356 1.52144443982599e-25 MirTarget;PITA;miRanda;miRNATAP -0.19588650676029 3.23415780318493e-14 NA NA NA hsa-miR-15a-5p EIF4B 0.812445324157528 4.50263417099822e-20 -0.65019836780356 1.52144443982599e-25 miRNATAP -0.158748562997593 4.58730473878287e-11 NA NA NA hsa-miR-185-5p EIF4B 0.482334746589337 3.68475879959415e-09 -0.65019836780356 1.52144443982599e-25 MirTarget -0.260058202476035 2.1915241574969e-23 NA NA NA hsa-miR-330-5p EIF4B 0.626063225953928 3.42215028606779e-09 -0.65019836780356 1.52144443982599e-25 miRNATAP -0.102458867136363 5.8358886607923e-07 NA NA NA hsa-miR-590-3p EIF4B 1.27438512890514 1.03164723481469e-23 -0.65019836780356 1.52144443982599e-25 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.157461933655438 5.99446351789919e-20 NA NA NA hsa-miR-26a-5p EIF4E -0.481180084102235 1.82368246174758e-10 0.269255020427265 1.05790226775164e-05 mirMAP -0.154217079131863 2.29252125869775e-08 NA NA NA hsa-miR-29a-3p EIF4E -0.699539666833076 1.13935003139957e-13 0.269255020427265 1.05790226775164e-05 mirMAP -0.124296545562299 1.39722119063186e-08 NA NA NA hsa-miR-361-5p EIF4E -0.0996867547900457 0.095428250126326 0.269255020427265 1.05790226775164e-05 miRanda;mirMAP -0.125999677820868 0.000415655162966611 NA NA NA hsa-miR-381-3p EIF4E -1.28028930293369 1.61402949866141e-23 0.269255020427265 1.05790226775164e-05 MirTarget;mirMAP -0.120308040349857 2.10719446650024e-14 NA NA NA hsa-miR-660-5p EIF4E 0.406910761707485 0.000156175371762464 0.269255020427265 1.05790226775164e-05 mirMAP -0.105699457757742 5.03122785788093e-08 NA NA NA hsa-miR-125a-5p EIF4EBP1 -0.635694700253268 3.6703235721638e-11 1.01321592334217 1.31060874763381e-12 miRNAWalker2_validate;MirTarget;miRanda;miRNATAP -0.262246438021565 2.76009521537076e-07 26646586 Increased expression of miR-125a and miR-125b inhibited invasion and migration of SKOV3 and OVCAR-429 ovarian cancer cells and was associated with a decrease in EIF4EBP1 expression ovarian cancer hsa-miR-125b-5p EIF4EBP1 -1.94393269763542 2.78180543229264e-58 1.01321592334217 1.31060874763381e-12 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.288352223423938 2.0288081394147e-14 17891175;26646586 Using a bioinformatics approach we have identified additional potential mRNA targets of one of the miRNAs miR-125b that are upregulated in prostate cancer and confirmed increased expression of one of these targets EIF4EBP1 in prostate cancer tissues;Increased expression of miR-125a and miR-125b inhibited invasion and migration of SKOV3 and OVCAR-429 ovarian cancer cells and was associated with a decrease in EIF4EBP1 expression ; prostate cancer;ovarian cancer hsa-miR-874-3p EIF4EBP1 -0.513415443180424 1.49285755109414e-06 1.01321592334217 1.31060874763381e-12 MirTarget -0.161830800923173 0.000481724419110573 NA NA NA hsa-let-7b-5p HIF1A -0.54215483448257 7.21347617597858e-08 -0.00924357669197828 0.936511798508899 miRNAWalker2_validate -0.11975460978938 0.00231961030933583 NA NA NA hsa-miR-320a HIF1A -0.287921276129346 0.00141693637596294 -0.00924357669197828 0.936511798508899 miRanda -0.129546185558833 0.00337549243956925 NA NA NA hsa-miR-338-3p HIF1A 0.0799903526884966 0.575137668326679 -0.00924357669197828 0.936511798508899 MirTarget;PITA;miRanda -0.146904692401628 1.15823485529806e-07 NA NA NA hsa-miR-361-5p HIF1A -0.0996867547900457 0.095428250126326 -0.00924357669197828 0.936511798508899 miRanda -0.209564314502827 0.00192643093014726 NA NA NA hsa-let-7a-3p IGF1 0.466622567891891 3.70886257943079e-07 -2.74966407318656 1.16668946763881e-41 mirMAP -0.598494517106358 2.99480834420479e-14 NA NA NA hsa-let-7f-1-3p IGF1 0.37532726250321 0.00156021688753682 -2.74966407318656 1.16668946763881e-41 mirMAP -0.284984074850365 5.12019686555637e-06 NA NA NA hsa-miR-130b-3p IGF1 1.38122163823846 1.00932179737836e-26 -2.74966407318656 1.16668946763881e-41 MirTarget -0.632738321082739 2.08097755219068e-32 NA NA NA hsa-miR-142-3p IGF1 1.53951237846104 2.06769936282034e-17 -2.74966407318656 1.16668946763881e-41 miRanda -0.123324920262687 0.00187203848886841 NA NA NA hsa-miR-148a-5p IGF1 0.572692271754695 2.14306251522796e-06 -2.74966407318656 1.16668946763881e-41 mirMAP -0.165502731566367 0.00629257314556201 NA NA NA hsa-miR-155-5p IGF1 1.09766314984151 4.55650930885814e-15 -2.74966407318656 1.16668946763881e-41 mirMAP -0.165951614876576 0.00129161967089585 NA NA NA hsa-miR-15b-3p IGF1 1.12898579025388 1.18050912917317e-14 -2.74966407318656 1.16668946763881e-41 mirMAP -0.538169881674298 1.72833038996145e-29 NA NA NA hsa-miR-16-1-3p IGF1 1.30142784811196 2.53343713753744e-29 -2.74966407318656 1.16668946763881e-41 mirMAP -0.666577091007243 4.14343498994569e-26 NA NA NA hsa-miR-181a-5p IGF1 0.635863607630183 6.72486918157744e-11 -2.74966407318656 1.16668946763881e-41 mirMAP -0.494938478163062 2.34360673909487e-11 NA NA NA hsa-miR-181b-5p IGF1 1.22749257795094 1.21998198830919e-27 -2.74966407318656 1.16668946763881e-41 mirMAP -0.585684202347318 2.25280244287885e-21 NA NA NA hsa-miR-181c-5p IGF1 0.574847839298605 4.51287502066478e-07 -2.74966407318656 1.16668946763881e-41 mirMAP -0.395598534798654 5.11211832683976e-10 NA NA NA hsa-miR-186-5p IGF1 -0.426987301460247 1.04129380549315e-05 -2.74966407318656 1.16668946763881e-41 mirMAP -0.219700941598902 0.00375910687826014 NA NA NA hsa-miR-19a-3p IGF1 0.817507952171848 3.76285090469625e-08 -2.74966407318656 1.16668946763881e-41 MirTarget -0.513925086378424 2.94832706936413e-27 NA NA NA hsa-miR-19b-1-5p IGF1 0.647704962003062 3.07687667945597e-07 -2.74966407318656 1.16668946763881e-41 mirMAP -0.553744322104364 7.97205759882393e-23 NA NA NA hsa-miR-19b-3p IGF1 0.139124391010031 0.255658553872934 -2.74966407318656 1.16668946763881e-41 MirTarget -0.446691776662058 5.00619914718767e-14 NA NA NA hsa-miR-20a-3p IGF1 -0.218902047543766 0.179868363625547 -2.74966407318656 1.16668946763881e-41 mirMAP -0.256736318876148 1.0275917705269e-08 NA NA NA hsa-miR-27a-3p IGF1 0.388496361379095 1.42373532086331e-05 -2.74966407318656 1.16668946763881e-41 miRNAWalker2_validate;miRTarBase -0.544265988607736 2.14223289540701e-11 NA NA NA hsa-miR-29b-3p IGF1 0.438847962603729 6.46722433236121e-05 -2.74966407318656 1.16668946763881e-41 MirTarget -0.414656321477745 3.77745108303762e-10 25592039 Luciferase reporter assays were conducted to determine the association between miR-29b and the insulin-like growth factor 1 IGF1 3' untranslated region 3'UTR; IGF1 an activator of PI3K/Akt signaling was confirmed as a novel target of miR-29b colorectal cancer hsa-miR-301a-3p IGF1 1.32170168375632 2.12280368957514e-15 -2.74966407318656 1.16668946763881e-41 MirTarget -0.553869611428521 1.38070780054886e-40 NA NA NA hsa-miR-320b IGF1 0.412787504747938 0.00113457276903985 -2.74966407318656 1.16668946763881e-41 miRNATAP -0.353937956338846 8.47295336022305e-10 NA NA NA hsa-miR-362-5p IGF1 -0.248676340901797 0.0726089851456282 -2.74966407318656 1.16668946763881e-41 mirMAP -0.161368577599581 0.00235431302635106 NA NA NA hsa-miR-3913-5p IGF1 0.71890413546147 2.61153227160465e-13 -2.74966407318656 1.16668946763881e-41 mirMAP -0.344116396893892 3.11162487969542e-06 NA NA NA hsa-miR-454-3p IGF1 1.28177672191095 6.84024979484587e-21 -2.74966407318656 1.16668946763881e-41 MirTarget -0.592555267211157 2.36575948576207e-31 NA NA NA hsa-miR-576-5p IGF1 0.0649387707567879 0.588791966096287 -2.74966407318656 1.16668946763881e-41 PITA;mirMAP;miRNATAP -0.338610461178183 2.7172717713968e-08 NA NA NA hsa-miR-590-3p IGF1 1.27438512890514 1.03164723481469e-23 -2.74966407318656 1.16668946763881e-41 MirTarget;miRanda;mirMAP;miRNATAP -0.58985675364928 6.40681378251621e-25 NA NA NA hsa-miR-629-5p IGF1 0.42411327890895 2.46262300605706e-05 -2.74966407318656 1.16668946763881e-41 mirMAP -0.48961361687082 1.21612287765371e-11 NA NA NA hsa-miR-29c-3p MAPK1 -0.0652732378039769 0.563774115756922 -0.282469104608855 4.85723866828359e-06 mirMAP -0.107930467813368 8.09848447187363e-09 NA NA NA hsa-miR-361-5p MAPK1 -0.0996867547900457 0.095428250126326 -0.282469104608855 4.85723866828359e-06 PITA;miRanda;mirMAP -0.263780179525808 1.39108568009728e-13 NA NA NA hsa-miR-3913-5p MAPK1 0.71890413546147 2.61153227160465e-13 -0.282469104608855 4.85723866828359e-06 mirMAP -0.145979254174869 5.54224263447113e-12 NA NA NA hsa-miR-660-5p MAPK1 0.406910761707485 0.000156175371762464 -0.282469104608855 4.85723866828359e-06 mirMAP -0.144747929471906 1.05117786154161e-13 NA NA NA hsa-miR-197-3p MAPK3 -0.526589453596294 3.61594599437195e-06 -0.0806112580526674 0.201094437565328 miRNATAP -0.106370513582673 1.47526386613596e-08 NA NA NA hsa-miR-103a-3p PDPK1 0.610673390034345 1.63113920514646e-12 -0.0553897078043679 0.47893230919387 mirMAP -0.195227401446081 1.40474326687401e-10 NA NA NA hsa-miR-106b-5p PDPK1 1.22477789913175 2.31787213143326e-32 -0.0553897078043679 0.47893230919387 mirMAP -0.188998401205378 1.5003883981558e-14 NA NA NA hsa-miR-107 PDPK1 0.678998026350662 2.56224148930538e-16 -0.0553897078043679 0.47893230919387 mirMAP -0.159185203283762 5.38122436376593e-07 NA NA NA hsa-miR-128-3p PDPK1 0.90296715955238 9.925204823863e-23 -0.0553897078043679 0.47893230919387 miRNAWalker2_validate -0.176951960154388 3.45376583543913e-10 NA NA NA hsa-miR-15a-5p PDPK1 0.812445324157528 4.50263417099822e-20 -0.0553897078043679 0.47893230919387 mirMAP -0.221903804018165 3.37728999804261e-14 NA NA NA hsa-miR-17-5p PDPK1 0.599531757298529 1.07318660415906e-05 -0.0553897078043679 0.47893230919387 miRNAWalker2_validate;mirMAP -0.118251463530882 1.11170801086741e-09 NA NA NA hsa-miR-185-5p PDPK1 0.482334746589337 3.68475879959415e-09 -0.0553897078043679 0.47893230919387 miRNAWalker2_validate -0.209025442029251 1.03227784292795e-10 NA NA NA hsa-miR-20a-5p PDPK1 0.44979911120222 0.000602386964327228 -0.0553897078043679 0.47893230919387 mirMAP -0.187876784201181 3.83298842174516e-21 NA NA NA hsa-miR-22-5p PDPK1 0.238328801322329 0.0377496760295305 -0.0553897078043679 0.47893230919387 miRNATAP -0.103270556943386 9.3434029051065e-06 NA NA NA hsa-miR-24-3p PDPK1 -0.120123317289941 0.21432376743243 -0.0553897078043679 0.47893230919387 miRNAWalker2_validate -0.112573425800778 4.9504814395065e-05 NA NA NA hsa-miR-27a-3p PDPK1 0.388496361379095 1.42373532086331e-05 -0.0553897078043679 0.47893230919387 miRNATAP -0.166657339522545 2.08058309346529e-08 NA NA NA hsa-miR-27b-3p PDPK1 -0.0796803270437447 0.410503155574393 -0.0553897078043679 0.47893230919387 miRNATAP -0.128280079054786 3.59271031339703e-06 NA NA NA hsa-miR-28-5p PDPK1 -0.14267073663385 0.0497619246260571 -0.0553897078043679 0.47893230919387 mirMAP -0.188098133932334 3.6777139194769e-07 NA NA NA hsa-miR-29a-3p PDPK1 -0.699539666833076 1.13935003139957e-13 -0.0553897078043679 0.47893230919387 mirMAP -0.123115773524495 1.11259237928009e-05 NA NA NA hsa-miR-361-5p PDPK1 -0.0996867547900457 0.095428250126326 -0.0553897078043679 0.47893230919387 miRanda;mirMAP -0.395197723069709 8.02735285255607e-19 NA NA NA hsa-miR-374a-3p PDPK1 0.34122393953022 2.28714105382856e-05 -0.0553897078043679 0.47893230919387 mirMAP -0.151612379692758 4.98877746993602e-06 NA NA NA hsa-miR-374b-5p PDPK1 -0.466781429946153 1.17238311619116e-08 -0.0553897078043679 0.47893230919387 miRNATAP -0.173756085269167 8.73605181551714e-08 NA NA NA hsa-miR-542-3p PDPK1 0.568822103820889 8.5699075257651e-07 -0.0553897078043679 0.47893230919387 mirMAP -0.121087390005675 1.29773467969966e-07 NA NA NA hsa-miR-93-5p PDPK1 1.01788600209314 1.24312921618126e-21 -0.0553897078043679 0.47893230919387 mirMAP -0.192079485583165 1.90008080577296e-15 NA NA NA hsa-miR-142-3p PGF 1.53951237846104 2.06769936282034e-17 0.187603779609442 0.0921943717527187 miRanda -0.110153556627631 7.64442465753915e-08 NA NA NA hsa-miR-326 PGF -1.54449030848141 1.04703417845594e-17 0.187603779609442 0.0921943717527187 mirMAP -0.12535880272214 1.12977476405779e-09 NA NA NA hsa-miR-330-5p PGF 0.626063225953928 3.42215028606779e-09 0.187603779609442 0.0921943717527187 mirMAP -0.169384385810917 2.04633751679976e-06 NA NA NA hsa-miR-766-3p PGF 0.496790679032227 8.22686414022553e-05 0.187603779609442 0.0921943717527187 MirTarget -0.149878694548497 6.09352519262623e-07 NA NA NA hsa-miR-146b-5p PIK3CA 0.631041661167954 6.20366593452965e-08 -0.881957552231161 1.15529457057533e-22 mirMAP -0.10172531442561 0.000163300940659646 NA NA NA hsa-miR-148a-5p PIK3CA 0.572692271754695 2.14306251522796e-06 -0.881957552231161 1.15529457057533e-22 mirMAP -0.111623090383025 1.82115916734019e-05 NA NA NA hsa-miR-200b-3p PIK3CA 2.11744072703209 1.66710572104191e-43 -0.881957552231161 1.15529457057533e-22 TargetScan -0.164394431071602 1.25931440199374e-17 NA NA NA hsa-miR-361-5p PIK3CA -0.0996867547900457 0.095428250126326 -0.881957552231161 1.15529457057533e-22 mirMAP -0.28523073173792 1.02307804662151e-07 NA NA NA hsa-miR-96-5p PIK3CA 3.24596558166606 1.92296159041707e-98 -0.881957552231161 1.15529457057533e-22 TargetScan -0.158039482109614 1.06514304964241e-18 NA NA NA hsa-miR-30b-3p PIK3CD -0.536462824497982 2.41814659272548e-05 -0.316904328019809 0.0048026997053421 MirTarget -0.12656414985523 3.07110294580941e-05 NA NA NA hsa-miR-484 PIK3CD 0.349444060004737 0.00154491249625173 -0.316904328019809 0.0048026997053421 MirTarget;miRNATAP -0.141552727299567 4.96089022907138e-05 NA NA NA hsa-miR-103a-3p PIK3R1 0.610673390034345 1.63113920514646e-12 -1.70627489565512 1.28475917565256e-44 MirTarget;miRNATAP -0.516011898515825 9.39970675304441e-26 NA NA NA hsa-miR-106b-5p PIK3R1 1.22477789913175 2.31787213143326e-32 -1.70627489565512 1.28475917565256e-44 MirTarget;miRNATAP -0.458684807618424 6.41212047089543e-31 NA NA NA hsa-miR-107 PIK3R1 0.678998026350662 2.56224148930538e-16 -1.70627489565512 1.28475917565256e-44 MirTarget;PITA;miRanda;miRNATAP -0.564782368968385 1.29413413077175e-28 NA NA NA hsa-miR-128-3p PIK3R1 0.90296715955238 9.925204823863e-23 -1.70627489565512 1.28475917565256e-44 MirTarget -0.464882086210543 2.18929508374026e-24 25962360 miR 128 3p suppresses hepatocellular carcinoma proliferation by regulating PIK3R1 and is correlated with the prognosis of HCC patients; Mechanistically miR-128-3p was confirmed to regulate PIK3R1 p85α expression thereby suppressing phosphatidylinositol 3-kinase PI3K/AKT pathway activation using qRT-PCR and western blot analysis; Hence we conclude that miR-128-3p which is frequently downregulated in HCC inhibits HCC progression by regulating PIK3R1 and PI3K/AKT activation and is a prognostic marker for HCC patients worse prognosis;progression liver cancer hsa-miR-1301-3p PIK3R1 1.80754972811286 2.96809840886499e-36 -1.70627489565512 1.28475917565256e-44 MirTarget -0.312737279865189 3.51588268231222e-28 NA NA NA hsa-miR-15a-5p PIK3R1 0.812445324157528 4.50263417099822e-20 -1.70627489565512 1.28475917565256e-44 MirTarget -0.467053807879393 1.27196995879228e-22 NA NA NA hsa-miR-15b-5p PIK3R1 0.788659356634696 1.13678211092534e-11 -1.70627489565512 1.28475917565256e-44 MirTarget -0.304923263873542 1.52536411684308e-16 NA NA NA hsa-miR-16-2-3p PIK3R1 0.286355254959005 0.0256946046884474 -1.70627489565512 1.28475917565256e-44 MirTarget -0.187390623272605 5.18756959426033e-08 NA NA NA hsa-miR-16-5p PIK3R1 0.46835991343556 1.91125356547776e-06 -1.70627489565512 1.28475917565256e-44 MirTarget -0.185144677288316 3.4393027748885e-05 NA NA NA hsa-miR-17-5p PIK3R1 0.599531757298529 1.07318660415906e-05 -1.70627489565512 1.28475917565256e-44 MirTarget;TargetScan;miRNATAP -0.305623214527227 2.73465966965389e-22 NA NA NA hsa-miR-182-5p PIK3R1 2.36408084103818 2.60011457600281e-72 -1.70627489565512 1.28475917565256e-44 miRNATAP -0.209986504782115 4.31661758321545e-12 NA NA NA hsa-miR-185-5p PIK3R1 0.482334746589337 3.68475879959415e-09 -1.70627489565512 1.28475917565256e-44 miRNATAP -0.576307293918371 1.92791131730155e-28 NA NA NA hsa-miR-200b-3p PIK3R1 2.11744072703209 1.66710572104191e-43 -1.70627489565512 1.28475917565256e-44 mirMAP -0.193888157381114 6.36921236487692e-13 NA NA NA hsa-miR-200c-3p PIK3R1 2.07038651806183 6.84613386286599e-51 -1.70627489565512 1.28475917565256e-44 mirMAP -0.257145031020416 2.3912254219973e-18 NA NA NA hsa-miR-20a-5p PIK3R1 0.44979911120222 0.000602386964327228 -1.70627489565512 1.28475917565256e-44 MirTarget;miRNATAP -0.329404805146422 7.47770247059783e-24 NA NA NA hsa-miR-21-5p PIK3R1 2.32007501846389 3.08394781855554e-137 -1.70627489565512 1.28475917565256e-44 miRNAWalker2_validate;MirTarget;miRNATAP -0.442813578327247 2.68375696066295e-30 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-29b-3p PIK3R1 0.438847962603729 6.46722433236121e-05 -1.70627489565512 1.28475917565256e-44 MirTarget;miRNATAP -0.212535407562809 1.00431864575306e-07 NA NA NA hsa-miR-320b PIK3R1 0.412787504747938 0.00113457276903985 -1.70627489565512 1.28475917565256e-44 miRNATAP -0.140552558146201 5.57745902628767e-05 NA NA NA hsa-miR-324-3p PIK3R1 0.404877731996915 0.000340036423920834 -1.70627489565512 1.28475917565256e-44 MirTarget;PITA;miRNATAP -0.224592588456891 6.81384539720142e-09 NA NA NA hsa-miR-330-3p PIK3R1 0.432728362037032 0.00041335506960812 -1.70627489565512 1.28475917565256e-44 MirTarget;PITA;miRNATAP -0.144041669892523 7.57903802651215e-05 NA NA NA hsa-miR-361-5p PIK3R1 -0.0996867547900457 0.095428250126326 -1.70627489565512 1.28475917565256e-44 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.278078422988115 0.000207710985727821 NA NA NA hsa-miR-429 PIK3R1 2.84108892259147 3.88520896426515e-64 -1.70627489565512 1.28475917565256e-44 mirMAP;miRNATAP -0.22503499935046 3.34180951947627e-21 NA NA NA hsa-miR-590-3p PIK3R1 1.27438512890514 1.03164723481469e-23 -1.70627489565512 1.28475917565256e-44 miRanda;mirMAP -0.239713681587516 7.2007499793076e-12 NA NA NA hsa-miR-590-5p PIK3R1 0.746515607868274 8.51300479640125e-09 -1.70627489565512 1.28475917565256e-44 MirTarget;PITA;miRanda;miRNATAP -0.209937562895491 3.68537681569131e-10 NA NA NA hsa-miR-629-3p PIK3R1 1.25035919247365 3.91361135469024e-14 -1.70627489565512 1.28475917565256e-44 MirTarget -0.122961236064884 5.54567297669118e-06 NA NA NA hsa-miR-93-5p PIK3R1 1.01788600209314 1.24312921618126e-21 -1.70627489565512 1.28475917565256e-44 MirTarget;miRNATAP -0.499295395694502 3.97678732290002e-38 NA NA NA hsa-miR-96-5p PIK3R1 3.24596558166606 1.92296159041707e-98 -1.70627489565512 1.28475917565256e-44 TargetScan;miRNATAP -0.245653154038236 3.77424010710224e-23 NA NA NA hsa-miR-126-3p PIK3R2 -1.17432628002954 1.02041618253013e-20 1.28293433832686 8.5972816204378e-73 miRNAWalker2_validate;miRTarBase -0.169496363080053 8.52458360518473e-17 21249429;26384552;27578985;26191164;25240815 Endothelial specific intron derived miR 126 is down regulated in human breast cancer and targets both VEGFA and PIK3R2; VEGFA and PIK3R2 were confirmed as the targets of miR-126 by luciferase reporter assay and Western blot;MicroRNA 126 suppresses proliferation of undifferentiated BRAFV600E and BRAFWT thyroid carcinoma through targeting PIK3R2 gene and repressing PI3K AKT proliferation survival signalling pathway; In addition miR-126 was found to act as proliferation suppressor targeting PIK3R2 gene and reducing p85β a regulatory subunit of PI3K kinase protein translation and lower AKT kinase activity;MiR 126 regulates proliferation and invasion in the bladder cancer BLS cell line by targeting the PIK3R2 mediated PI3K/Akt signaling pathway; A direct regulatory relationship between miR-126 and the PIK3R2 gene was demonstrated by luciferase reporter assays; Quantitative real-time polymerase chain reaction was used to measure miR-126 and PIK3R2 expressions; Luciferase assays showed that miR-126 significantly inhibited the PIK3R2 3' untranslated region 3'UTR luciferase reporter activity P<0.05; Overexpression of miR-126 negatively regulated the target gene PIK3R2 and further inhibited the PI3K/Akt signaling pathway thereby inhibiting proliferation migration and invasion and promoting apoptosis in BLS cells;Restoration of miR-126 in EC109 cells induced a reduction in PIK3R2 protein levels accompanied with a substantial reduction in phosphorylated AKT levels in EC109 cells suggesting impairment in PI3K/AKT signaling pathway; The luciferase reporter assay confirmed that PIK3R2 was a direct target of miR-126; Taken together our study suggests that miR-126 functions as a potential tumor suppressor in ESCC progression via regulating PI3K/AKT signaling pathway partly by targeting PIK3R2 and targeting of miR-126 may provide a novel strategy for the diagnosis and treatment of ESCC;MiR 126 3p suppresses tumor metastasis and angiogenesis of hepatocellular carcinoma by targeting LRP6 and PIK3R2; LRP6 and PIK3R2 were identified as targets of miR-126-3p; Silencing LRP6 and PIK3R2 had similar effects of miR-126-3p restoration on metastasis and angiogenesis individually in HCC cells; Furthermore the miR-126-3p level was inversely correlated with LRP6 and PIK3R2 in HCC tissues; In addition the rescue experiments indicated that the metastasis and angiogenesis functions of miR-126-3p were mediated by LRP6 and PIK3R2 ;poor survival;;progression;metastasis breast cancer;thyroid cancer;bladder cancer;esophageal cancer;liver cancer hsa-miR-28-5p PIK3R2 -0.14267073663385 0.0497619246260571 1.28293433832686 8.5972816204378e-73 miRanda -0.170225138245223 4.06181677270291e-06 NA NA NA hsa-miR-30b-5p PIK3R2 -0.46540603860146 2.4709940429591e-05 1.28293433832686 8.5972816204378e-73 miRNATAP -0.111541133552651 3.5447180691879e-06 NA NA NA hsa-miR-30c-5p PIK3R2 -0.393222674580066 8.06961465717306e-05 1.28293433832686 8.5972816204378e-73 miRNAWalker2_validate;miRNATAP -0.102854891876324 0.000118472431445014 NA NA NA hsa-miR-30d-5p PIK3R2 -0.247082219011045 0.00406717930063148 1.28293433832686 8.5972816204378e-73 miRNATAP -0.135541098242265 1.30568664423737e-05 NA NA NA hsa-miR-320a PIK3R2 -0.287921276129346 0.00141693637596294 1.28293433832686 8.5972816204378e-73 miRanda -0.151022063052727 3.16338469232646e-07 NA NA NA hsa-miR-491-5p PIK3R2 -1.04307210952796 1.14586501470398e-15 1.28293433832686 8.5972816204378e-73 miRanda -0.116485616092769 7.44579853361516e-09 NA NA NA hsa-miR-181a-5p PIK3R3 0.635863607630183 6.72486918157744e-11 0.559172960265555 3.98014986716526e-09 MirTarget;miRNATAP -0.146056981056209 1.20649375988888e-05 NA NA NA hsa-miR-19b-3p PIK3R3 0.139124391010031 0.255658553872934 0.559172960265555 3.98014986716526e-09 MirTarget;miRNATAP -0.109224067759979 4.71454242795867e-05 NA NA NA hsa-miR-217 PIK3R3 -0.616728851115349 8.64977119332241e-05 0.559172960265555 3.98014986716526e-09 PITA;miRanda -0.118432783728797 1.05730160913028e-08 NA NA NA hsa-miR-25-3p PIK3R3 -0.00546790775985073 0.944061771389468 0.559172960265555 3.98014986716526e-09 MirTarget -0.129911102729152 0.00226643466666436 NA NA NA hsa-miR-26a-5p PIK3R3 -0.481180084102235 1.82368246174758e-10 0.559172960265555 3.98014986716526e-09 miRNATAP -0.28216506702381 5.37056936747542e-11 NA NA NA hsa-miR-374a-5p PIK3R3 -0.239709888246804 0.00309819667153627 0.559172960265555 3.98014986716526e-09 mirMAP -0.121442827230575 0.0029020400924295 NA NA NA hsa-miR-374b-5p PIK3R3 -0.466781429946153 1.17238311619116e-08 0.559172960265555 3.98014986716526e-09 mirMAP -0.120196538768652 0.00271578207935794 NA NA NA hsa-miR-381-3p PIK3R3 -1.28028930293369 1.61402949866141e-23 0.559172960265555 3.98014986716526e-09 mirMAP -0.140767078074606 1.38941193259491e-08 NA NA NA hsa-miR-532-5p PIK3R3 0.0386976222860582 0.682018574136515 0.559172960265555 3.98014986716526e-09 mirMAP -0.140279487612118 5.85354025061255e-05 NA NA NA hsa-miR-92a-3p PIK3R3 -0.342420481092807 0.000732275969501111 0.559172960265555 3.98014986716526e-09 MirTarget;miRNATAP -0.227757876133252 1.19233380886192e-12 NA NA NA hsa-miR-125a-5p PIK3R5 -0.635694700253268 3.6703235721638e-11 0.311128035887536 0.0038375952038782 MirTarget;miRanda -0.280593880513026 8.91996620676494e-14 NA NA NA hsa-miR-182-5p PIK3R5 2.36408084103818 2.60011457600281e-72 0.311128035887536 0.0038375952038782 MirTarget -0.108305079676846 2.32094065834864e-05 NA NA NA hsa-miR-128-3p PRKAA1 0.90296715955238 9.925204823863e-23 -0.889722997110138 6.68547349344403e-22 miRNAWalker2_validate -0.203711118503965 2.87586951912717e-09 NA NA NA hsa-miR-130b-3p PRKAA1 1.38122163823846 1.00932179737836e-26 -0.889722997110138 6.68547349344403e-22 miRNAWalker2_validate;MirTarget;miRNATAP -0.102341099053503 2.95589264304139e-05 NA NA NA hsa-miR-148b-3p PRKAA1 1.0552576751879 1.6679285705231e-29 -0.889722997110138 6.68547349344403e-22 miRNAWalker2_validate;MirTarget -0.144460761230633 1.70583649615035e-05 NA NA NA hsa-miR-15a-5p PRKAA1 0.812445324157528 4.50263417099822e-20 -0.889722997110138 6.68547349344403e-22 MirTarget -0.317615312742036 2.43574896376608e-19 NA NA NA hsa-miR-15b-5p PRKAA1 0.788659356634696 1.13678211092534e-11 -0.889722997110138 6.68547349344403e-22 MirTarget -0.113980224735419 3.72256160222342e-05 NA NA NA hsa-miR-182-5p PRKAA1 2.36408084103818 2.60011457600281e-72 -0.889722997110138 6.68547349344403e-22 MirTarget -0.12957259010959 7.74120097344211e-09 NA NA NA hsa-miR-20a-5p PRKAA1 0.44979911120222 0.000602386964327228 -0.889722997110138 6.68547349344403e-22 mirMAP -0.127482024088913 2.29558821504195e-07 NA NA NA hsa-miR-301a-3p PRKAA1 1.32170168375632 2.12280368957514e-15 -0.889722997110138 6.68547349344403e-22 MirTarget;miRNATAP -0.111641895127187 5.76713491206456e-09 NA NA NA hsa-miR-30d-3p PRKAA1 0.264544633563642 0.00755023189129747 -0.889722997110138 6.68547349344403e-22 MirTarget;miRNATAP -0.150165899451655 4.84642713120332e-06 NA NA NA hsa-miR-429 PRKAA1 2.84108892259147 3.88520896426515e-64 -0.889722997110138 6.68547349344403e-22 miRNATAP -0.141667891084818 1.10952877434855e-15 NA NA NA hsa-miR-454-3p PRKAA1 1.28177672191095 6.84024979484587e-21 -0.889722997110138 6.68547349344403e-22 MirTarget;miRNATAP -0.134963384764347 6.03158027315945e-09 NA NA NA hsa-miR-769-5p PRKAA1 0.564871766265874 8.16695101656941e-10 -0.889722997110138 6.68547349344403e-22 MirTarget;PITA -0.156145941793697 8.51973967414274e-06 NA NA NA hsa-let-7d-5p PRKAA2 0.410958462607207 6.07808182756787e-06 -0.579847549865762 0.0120328308442779 MirTarget -0.253927364326718 0.00361978152126917 NA NA NA hsa-let-7i-5p PRKAA2 -0.333419326258177 3.56960810786801e-08 -0.579847549865762 0.0120328308442779 MirTarget -0.434247047501726 0.00099975084098266 NA NA NA hsa-miR-106b-5p PRKAA2 1.22477789913175 2.31787213143326e-32 -0.579847549865762 0.0120328308442779 mirMAP -0.407309465215687 2.87950289122621e-08 NA NA NA hsa-miR-130b-3p PRKAA2 1.38122163823846 1.00932179737836e-26 -0.579847549865762 0.0120328308442779 MirTarget -0.236959907465252 7.269812745952e-05 NA NA NA hsa-miR-142-5p PRKAA2 1.16509303143593 1.96641162209073e-13 -0.579847549865762 0.0120328308442779 mirMAP -0.308494315080149 2.59550351577519e-10 NA NA NA hsa-miR-146a-5p PRKAA2 0.102405752365098 0.486975378688068 -0.579847549865762 0.0120328308442779 MirTarget -0.303068137585273 1.45529396860407e-08 NA NA NA hsa-miR-146b-5p PRKAA2 0.631041661167954 6.20366593452965e-08 -0.579847549865762 0.0120328308442779 MirTarget -0.466570898192425 2.87992191143047e-12 NA NA NA hsa-miR-15b-3p PRKAA2 1.12898579025388 1.18050912917317e-14 -0.579847549865762 0.0120328308442779 mirMAP -0.245586956351096 3.75844225220248e-06 NA NA NA hsa-miR-16-2-3p PRKAA2 0.286355254959005 0.0256946046884474 -0.579847549865762 0.0120328308442779 mirMAP -0.268112091248467 1.5313383960563e-05 NA NA NA hsa-miR-17-5p PRKAA2 0.599531757298529 1.07318660415906e-05 -0.579847549865762 0.0120328308442779 mirMAP -0.294736369867022 3.19418199550823e-07 NA NA NA hsa-miR-181a-5p PRKAA2 0.635863607630183 6.72486918157744e-11 -0.579847549865762 0.0120328308442779 mirMAP -0.425977225966366 1.12553795472933e-07 NA NA NA hsa-miR-181b-5p PRKAA2 1.22749257795094 1.21998198830919e-27 -0.579847549865762 0.0120328308442779 mirMAP -0.402894448830963 2.57710767596897e-09 NA NA NA hsa-miR-19a-3p PRKAA2 0.817507952171848 3.76285090469625e-08 -0.579847549865762 0.0120328308442779 mirMAP -0.223371384798626 2.3136263934908e-05 NA NA NA hsa-miR-203a-3p PRKAA2 1.67084394806148 6.06522273352132e-14 -0.579847549865762 0.0120328308442779 MirTarget -0.127404255594052 0.000267649490057364 NA NA NA hsa-miR-20a-5p PRKAA2 0.44979911120222 0.000602386964327228 -0.579847549865762 0.0120328308442779 mirMAP -0.346885432705756 7.06226699554703e-09 NA NA NA hsa-miR-21-3p PRKAA2 2.17476065946878 5.15299442583591e-75 -0.579847549865762 0.0120328308442779 mirMAP -0.257680881978514 2.16873974422669e-05 NA NA NA hsa-miR-22-5p PRKAA2 0.238328801322329 0.0377496760295305 -0.579847549865762 0.0120328308442779 mirMAP -0.236371300737833 0.000631744857978216 NA NA NA hsa-miR-301a-3p PRKAA2 1.32170168375632 2.12280368957514e-15 -0.579847549865762 0.0120328308442779 MirTarget -0.199811074896772 2.06431978910307e-05 NA NA NA hsa-miR-30b-5p PRKAA2 -0.46540603860146 2.4709940429591e-05 -0.579847549865762 0.0120328308442779 MirTarget -0.239154411813247 0.000844867804972869 NA NA NA hsa-miR-30d-3p PRKAA2 0.264544633563642 0.00755023189129747 -0.579847549865762 0.0120328308442779 MirTarget;miRNATAP -0.292199265560775 0.000269897209542169 NA NA NA hsa-miR-30d-5p PRKAA2 -0.247082219011045 0.00406717930063148 -0.579847549865762 0.0120328308442779 MirTarget -0.309661319614685 0.000819102278720473 NA NA NA hsa-miR-335-3p PRKAA2 -1.88448538773649 2.09538234398335e-32 -0.579847549865762 0.0120328308442779 MirTarget -0.125289555996901 0.00892382059630128 NA NA NA hsa-miR-340-5p PRKAA2 1.0857159627596 4.94471062546756e-24 -0.579847549865762 0.0120328308442779 MirTarget -0.322802145820831 6.75061943901237e-06 NA NA NA hsa-miR-500a-5p PRKAA2 0.209805801129289 0.119177819862398 -0.579847549865762 0.0120328308442779 mirMAP -0.411392653460274 3.23149194968278e-12 NA NA NA hsa-miR-589-5p PRKAA2 0.367182541239722 1.67804815542873e-05 -0.579847549865762 0.0120328308442779 MirTarget -0.416057776223634 7.30350634476401e-06 NA NA NA hsa-miR-590-3p PRKAA2 1.27438512890514 1.03164723481469e-23 -0.579847549865762 0.0120328308442779 mirMAP;miRNATAP -0.252553744754276 6.76594678507493e-05 NA NA NA hsa-miR-93-5p PRKAA2 1.01788600209314 1.24312921618126e-21 -0.579847549865762 0.0120328308442779 mirMAP -0.403745175357699 2.28259007015548e-08 NA NA NA hsa-miR-98-5p PRKAA2 0.656336869298973 9.03113188590466e-15 -0.579847549865762 0.0120328308442779 miRNAWalker2_validate;MirTarget -0.543058840822084 3.50897487370215e-09 NA NA NA hsa-miR-199a-5p RHEB -0.314703593105081 0.00909304983051124 0.313579869806246 6.00889396723587e-07 PITA;miRanda;miRNATAP -0.143553921266532 4.04630951633478e-16 NA NA NA hsa-miR-199b-5p RHEB -1.37022396448377 3.25758057539223e-26 0.313579869806246 6.00889396723587e-07 PITA;miRanda -0.123803296102846 9.10616206978519e-15 NA NA NA hsa-miR-155-5p RICTOR 1.09766314984151 4.55650930885814e-15 -0.572696811642445 2.30364963045589e-12 miRNAWalker2_validate;miRNATAP -0.103484030374185 1.71994509395212e-07 NA NA NA hsa-miR-15a-5p RICTOR 0.812445324157528 4.50263417099822e-20 -0.572696811642445 2.30364963045589e-12 MirTarget;miRNATAP -0.303447965168191 3.75319298470152e-23 NA NA NA hsa-miR-16-1-3p RICTOR 1.30142784811196 2.53343713753744e-29 -0.572696811642445 2.30364963045589e-12 MirTarget -0.115903979550794 3.48858623719758e-06 NA NA NA hsa-miR-181a-5p RICTOR 0.635863607630183 6.72486918157744e-11 -0.572696811642445 2.30364963045589e-12 mirMAP -0.237293093922883 5.91468479845393e-17 NA NA NA hsa-miR-181b-5p RICTOR 1.22749257795094 1.21998198830919e-27 -0.572696811642445 2.30364963045589e-12 mirMAP -0.22028556988055 2.42010537062698e-20 NA NA NA hsa-miR-181c-5p RICTOR 0.574847839298605 4.51287502066478e-07 -0.572696811642445 2.30364963045589e-12 mirMAP -0.100760994882859 4.55914985214599e-05 NA NA NA hsa-miR-185-5p RICTOR 0.482334746589337 3.68475879959415e-09 -0.572696811642445 2.30364963045589e-12 MirTarget -0.329366333635565 1.53299804608517e-22 NA NA NA hsa-miR-18a-5p RICTOR 0.969066793715868 1.69069796425892e-08 -0.572696811642445 2.30364963045589e-12 miRNAWalker2_validate -0.115801044552433 7.86023931866078e-13 NA NA NA hsa-miR-194-5p RICTOR 0.467781870340114 1.0386810618625e-07 -0.572696811642445 2.30364963045589e-12 MirTarget -0.107615474578424 0.000818752229475053 NA NA NA hsa-miR-27a-3p RICTOR 0.388496361379095 1.42373532086331e-05 -0.572696811642445 2.30364963045589e-12 miRNATAP -0.194128283887536 6.46652053843961e-10 NA NA NA hsa-miR-27b-3p RICTOR -0.0796803270437447 0.410503155574393 -0.572696811642445 2.30364963045589e-12 miRNATAP -0.131850388773752 6.91273776901727e-06 NA NA NA hsa-miR-340-5p RICTOR 1.0857159627596 4.94471062546756e-24 -0.572696811642445 2.30364963045589e-12 mirMAP -0.215778842086001 1.27076657603489e-17 NA NA NA hsa-miR-500a-5p RICTOR 0.209805801129289 0.119177819862398 -0.572696811642445 2.30364963045589e-12 MirTarget;mirMAP -0.107169984424043 4.61812683522438e-07 NA NA NA hsa-miR-660-5p RICTOR 0.406910761707485 0.000156175371762464 -0.572696811642445 2.30364963045589e-12 MirTarget -0.270658236218574 3.06462003761086e-26 NA NA NA hsa-miR-98-5p RICTOR 0.656336869298973 9.03113188590466e-15 -0.572696811642445 2.30364963045589e-12 MirTarget -0.184823199886243 1.95855365024318e-08 NA NA NA hsa-miR-125a-5p RPS6KA1 -0.635694700253268 3.6703235721638e-11 1.00256510904029 1.46599111482776e-34 MirTarget;PITA;miRanda -0.106622289814942 0.000408128374437011 NA NA NA hsa-miR-125b-5p RPS6KA1 -1.94393269763542 2.78180543229264e-58 1.00256510904029 1.46599111482776e-34 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.138027596245383 6.3071430728344e-10 NA NA NA hsa-miR-139-5p RPS6KA1 -3.25846663863766 2.62018989415003e-112 1.00256510904029 1.46599111482776e-34 miRanda -0.156690112707771 7.04064981880923e-20 NA NA NA hsa-miR-335-3p RPS6KA1 -1.88448538773649 2.09538234398335e-32 1.00256510904029 1.46599111482776e-34 MirTarget -0.144963406126286 6.42280497225378e-17 NA NA NA hsa-let-7g-3p RPS6KA2 0.5854327663695 0.000371711766083627 -1.06112701609507 1.34339346025472e-29 MirTarget -0.111600921985962 2.77540875129883e-08 NA NA NA hsa-miR-130b-5p RPS6KA2 1.0573161199584 2.55177349228739e-12 -1.06112701609507 1.34339346025472e-29 mirMAP -0.171926517516172 1.08296122809856e-15 NA NA NA hsa-miR-17-5p RPS6KA2 0.599531757298529 1.07318660415906e-05 -1.06112701609507 1.34339346025472e-29 TargetScan -0.222822755541125 9.19238138746822e-21 NA NA NA hsa-miR-185-3p RPS6KA2 0.86591374114446 7.8790769678542e-10 -1.06112701609507 1.34339346025472e-29 MirTarget -0.148831770250574 2.9912494378753e-10 NA NA NA hsa-miR-193a-3p RPS6KA2 0.310617999804917 0.00477640270974957 -1.06112701609507 1.34339346025472e-29 mirMAP -0.173249397713506 8.96777762296435e-09 NA NA NA hsa-miR-19a-3p RPS6KA2 0.817507952171848 3.76285090469625e-08 -1.06112701609507 1.34339346025472e-29 MirTarget -0.179126566533993 2.87975380365162e-16 NA NA NA hsa-miR-19b-3p RPS6KA2 0.139124391010031 0.255658553872934 -1.06112701609507 1.34339346025472e-29 MirTarget -0.161006226162469 2.86515716406055e-09 NA NA NA hsa-miR-200b-3p RPS6KA2 2.11744072703209 1.66710572104191e-43 -1.06112701609507 1.34339346025472e-29 TargetScan -0.19593222828491 2.13416782438513e-22 NA NA NA hsa-miR-200c-3p RPS6KA2 2.07038651806183 6.84613386286599e-51 -1.06112701609507 1.34339346025472e-29 miRNATAP -0.281022132531582 1.82177016356237e-38 NA NA NA hsa-miR-21-3p RPS6KA2 2.17476065946878 5.15299442583591e-75 -1.06112701609507 1.34339346025472e-29 MirTarget -0.24334264336363 1.98040233570223e-22 NA NA NA hsa-miR-30b-5p RPS6KA2 -0.46540603860146 2.4709940429591e-05 -1.06112701609507 1.34339346025472e-29 MirTarget -0.110298603171651 0.000253431254273401 NA NA NA hsa-miR-30d-5p RPS6KA2 -0.247082219011045 0.00406717930063148 -1.06112701609507 1.34339346025472e-29 MirTarget;miRNATAP -0.148759301389742 0.000132297251897939 NA NA NA hsa-miR-30e-5p RPS6KA2 0.293491764699475 0.000372291967271834 -1.06112701609507 1.34339346025472e-29 MirTarget -0.213399770733942 1.2882063036701e-07 NA NA NA hsa-miR-3127-5p RPS6KA2 0.903405128081314 1.1325923598273e-12 -1.06112701609507 1.34339346025472e-29 mirMAP -0.254813783564397 6.3212055626234e-24 NA NA NA hsa-miR-429 RPS6KA2 2.84108892259147 3.88520896426515e-64 -1.06112701609507 1.34339346025472e-29 miRanda;miRNATAP -0.191117874968675 1.07705854301622e-26 NA NA NA hsa-miR-589-5p RPS6KA2 0.367182541239722 1.67804815542873e-05 -1.06112701609507 1.34339346025472e-29 mirMAP -0.294301339039086 2.54864043107873e-14 NA NA NA hsa-miR-93-3p RPS6KA2 0.627759242044891 3.62527588304617e-06 -1.06112701609507 1.34339346025472e-29 MirTarget -0.194961316172869 5.99811603663702e-16 NA NA NA hsa-let-7e-5p RPS6KA3 0.261471269338985 0.00191077095550257 -1.37237205082117 2.11044411412942e-35 miRNATAP -0.157060484548625 0.000871275403936363 NA NA NA hsa-miR-103a-3p RPS6KA3 0.610673390034345 1.63113920514646e-12 -1.37237205082117 2.11044411412942e-35 MirTarget -0.445736137422984 6.6306047939867e-24 NA NA NA hsa-miR-106b-5p RPS6KA3 1.22477789913175 2.31787213143326e-32 -1.37237205082117 2.11044411412942e-35 miRNATAP -0.162439827717479 1.00251039325415e-05 NA NA NA hsa-miR-107 RPS6KA3 0.678998026350662 2.56224148930538e-16 -1.37237205082117 2.11044411412942e-35 MirTarget;PITA;miRanda;miRNATAP -0.265777635777206 1.41892389468232e-08 NA NA NA hsa-miR-15a-5p RPS6KA3 0.812445324157528 4.50263417099822e-20 -1.37237205082117 2.11044411412942e-35 MirTarget;miRNATAP -0.358183106164086 9.94945208595321e-17 NA NA NA hsa-miR-181a-5p RPS6KA3 0.635863607630183 6.72486918157744e-11 -1.37237205082117 2.11044411412942e-35 MirTarget;mirMAP;miRNATAP -0.197115676665566 9.09685071705532e-07 NA NA NA hsa-miR-181b-5p RPS6KA3 1.22749257795094 1.21998198830919e-27 -1.37237205082117 2.11044411412942e-35 MirTarget;mirMAP;miRNATAP -0.207881783481224 7.32003086534495e-10 NA NA NA hsa-miR-181c-5p RPS6KA3 0.574847839298605 4.51287502066478e-07 -1.37237205082117 2.11044411412942e-35 MirTarget;mirMAP;miRNATAP -0.121420661637188 0.000442040350968237 NA NA NA hsa-miR-181d-5p RPS6KA3 0.782618466877349 1.2821116358212e-09 -1.37237205082117 2.11044411412942e-35 MirTarget -0.126354396119077 3.1383002502487e-05 NA NA NA hsa-miR-183-5p RPS6KA3 2.95681814393872 1.09965777344285e-92 -1.37237205082117 2.11044411412942e-35 MirTarget;miRNATAP -0.221655186837094 1.11615961728505e-20 NA NA NA hsa-miR-200b-3p RPS6KA3 2.11744072703209 1.66710572104191e-43 -1.37237205082117 2.11044411412942e-35 MirTarget;TargetScan -0.241869137597393 3.09939082839428e-24 NA NA NA hsa-miR-200c-3p RPS6KA3 2.07038651806183 6.84613386286599e-51 -1.37237205082117 2.11044411412942e-35 MirTarget;miRNATAP -0.26058220909184 2.84165141998717e-23 NA NA NA hsa-miR-21-5p RPS6KA3 2.32007501846389 3.08394781855554e-137 -1.37237205082117 2.11044411412942e-35 miRNAWalker2_validate;mirMAP;miRNATAP -0.318123624363205 1.65398865078165e-19 NA NA NA hsa-miR-29b-2-5p RPS6KA3 -0.263499971180298 0.0400001755611965 -1.37237205082117 2.11044411412942e-35 mirMAP -0.163218321920653 1.05519620181758e-07 NA NA NA hsa-miR-30d-3p RPS6KA3 0.264544633563642 0.00755023189129747 -1.37237205082117 2.11044411412942e-35 mirMAP -0.110742420352922 0.00578076092410611 NA NA NA hsa-miR-340-5p RPS6KA3 1.0857159627596 4.94471062546756e-24 -1.37237205082117 2.11044411412942e-35 mirMAP -0.187838161869725 1.46589562184612e-07 NA NA NA hsa-miR-429 RPS6KA3 2.84108892259147 3.88520896426515e-64 -1.37237205082117 2.11044411412942e-35 MirTarget;PITA;miRanda;miRNATAP -0.220289857421514 3.31100891599358e-25 NA NA NA hsa-miR-93-5p RPS6KA3 1.01788600209314 1.24312921618126e-21 -1.37237205082117 2.11044411412942e-35 miRNATAP -0.21802591930108 1.4162839807829e-09 NA NA NA hsa-miR-15a-5p RPS6KA6 0.812445324157528 4.50263417099822e-20 -0.511255169559984 0.0373906669865375 MirTarget -0.637819902436688 5.07170804664232e-12 NA NA NA hsa-miR-15b-5p RPS6KA6 0.788659356634696 1.13678211092534e-11 -0.511255169559984 0.0373906669865375 MirTarget -0.228976933141519 0.00141289791914474 NA NA NA hsa-miR-17-5p RPS6KA6 0.599531757298529 1.07318660415906e-05 -0.511255169559984 0.0373906669865375 TargetScan -0.235591344457259 0.000128008040272393 NA NA NA hsa-miR-19a-3p RPS6KA6 0.817507952171848 3.76285090469625e-08 -0.511255169559984 0.0373906669865375 MirTarget -0.194741831996197 0.000530948142416833 NA NA NA hsa-miR-374a-5p RPS6KA6 -0.239709888246804 0.00309819667153627 -0.511255169559984 0.0373906669865375 MirTarget -0.351158498776282 0.000779488589640656 NA NA NA hsa-miR-374b-5p RPS6KA6 -0.466781429946153 1.17238311619116e-08 -0.511255169559984 0.0373906669865375 MirTarget -0.266178330056691 0.00967645872612687 NA NA NA hsa-miR-532-5p RPS6KA6 0.0386976222860582 0.682018574136515 -0.511255169559984 0.0373906669865375 MirTarget;PITA;miRNATAP -0.493703576177767 3.0511809768509e-08 NA NA NA hsa-miR-590-3p RPS6KA6 1.27438512890514 1.03164723481469e-23 -0.511255169559984 0.0373906669865375 MirTarget;miRanda;mirMAP;miRNATAP -0.324054984263013 1.44112437247895e-06 NA NA NA hsa-miR-889-3p RPS6KA6 -0.377352927733213 0.00501260024755438 -0.511255169559984 0.0373906669865375 MirTarget -0.194094317734353 0.00198895476553661 NA NA NA hsa-miR-103a-3p RPS6KB1 0.610673390034345 1.63113920514646e-12 -0.0571936206706596 0.498093695192352 miRNAWalker2_validate -0.13730715753257 3.30989618940789e-05 NA NA NA hsa-miR-148a-5p RPS6KB1 0.572692271754695 2.14306251522796e-06 -0.0571936206706596 0.498093695192352 MirTarget;miRNATAP -0.171064566688249 3.39982513466234e-13 NA NA NA hsa-miR-181a-5p RPS6KB1 0.635863607630183 6.72486918157744e-11 -0.0571936206706596 0.498093695192352 MirTarget;miRNATAP -0.130436776786364 8.76017102192071e-06 NA NA NA hsa-miR-181c-5p RPS6KB1 0.574847839298605 4.51287502066478e-07 -0.0571936206706596 0.498093695192352 MirTarget;miRNATAP -0.186058639495696 7.95661299115965e-14 NA NA NA hsa-miR-181d-5p RPS6KB1 0.782618466877349 1.2821116358212e-09 -0.0571936206706596 0.498093695192352 MirTarget -0.164885796389909 5.09783807829002e-14 NA NA NA hsa-miR-218-5p RPS6KB1 -1.02621788318234 2.9221925445771e-23 -0.0571936206706596 0.498093695192352 miRNATAP -0.15390061742019 1.35815707120652e-08 25943352 We found that decreased miR-218 expression in GBM cells also increased the expression of genes encoding additional upstream and downstream components of RTK signaling pathways including the RTK platelet-derived growth factor receptor α PDGFRα and the kinases ribosomal S6 kinase 2 RSK2 and S6 kinase 1 S6K1 that collectively overrode the negative feedback mechanism glioblastoma hsa-miR-223-3p RPS6KB1 -0.966406159689943 7.90612601654887e-12 -0.0571936206706596 0.498093695192352 MirTarget -0.140401561003547 1.98539879754319e-12 NA NA NA hsa-miR-27a-3p RPS6KB1 0.388496361379095 1.42373532086331e-05 -0.0571936206706596 0.498093695192352 MirTarget;miRNATAP -0.152883993564015 2.01871224053452e-06 NA NA NA hsa-miR-30a-5p RPS6KB1 -0.392489994825279 0.00954894667761676 -0.0571936206706596 0.498093695192352 mirMAP;miRNATAP -0.117644522086258 4.71701520431133e-10 NA NA NA hsa-miR-340-5p RPS6KB1 1.0857159627596 4.94471062546756e-24 -0.0571936206706596 0.498093695192352 mirMAP -0.12986566290195 6.5302066469287e-07 NA NA NA hsa-miR-361-5p RPS6KB1 -0.0996867547900457 0.095428250126326 -0.0571936206706596 0.498093695192352 miRanda -0.315724779040643 8.68560752083352e-11 NA NA NA hsa-miR-369-3p RPS6KB1 0.0880848299432269 0.48519534195924 -0.0571936206706596 0.498093695192352 MirTarget;PITA -0.109811993589112 1.74070420680125e-06 NA NA NA hsa-miR-381-3p RPS6KB1 -1.28028930293369 1.61402949866141e-23 -0.0571936206706596 0.498093695192352 MirTarget -0.11550176003524 1.23132177175341e-07 NA NA NA hsa-miR-455-5p RPS6KB1 0.284641224662773 0.0357572339594277 -0.0571936206706596 0.498093695192352 MirTarget;PITA;miRanda -0.195839125781244 5.6227516619354e-21 NA NA NA hsa-miR-542-3p RPS6KB1 0.568822103820889 8.5699075257651e-07 -0.0571936206706596 0.498093695192352 miRNATAP -0.146106785368595 3.33819415150885e-09 NA NA NA hsa-miR-125a-5p RPS6KB2 -0.635694700253268 3.6703235721638e-11 1.06459449292244 1.07488926981491e-32 miRanda -0.276064765205245 1.34823621720886e-17 NA NA NA hsa-miR-26b-5p RPS6KB2 -0.331527896896866 0.000551258576575092 1.06459449292244 1.07488926981491e-32 miRNAWalker2_validate -0.119704281563459 0.00031805074232755 NA NA NA hsa-miR-199a-3p STK11 -0.174830922802531 0.138748242352612 0.544842212403913 5.57417996369907e-11 PITA;miRNATAP -0.209034875931642 2.73576834835512e-18 NA NA NA hsa-miR-199b-3p STK11 -0.173412359075504 0.143232985227463 0.544842212403913 5.57417996369907e-11 PITA -0.209157826415224 2.02086037375367e-18 NA NA NA hsa-miR-326 STK11 -1.54449030848141 1.04703417845594e-17 0.544842212403913 5.57417996369907e-11 miRanda -0.166560489246979 4.2942013137581e-28 NA NA NA hsa-miR-330-5p STK11 0.626063225953928 3.42215028606779e-09 0.544842212403913 5.57417996369907e-11 miRanda -0.150358933571276 2.12169768579404e-08 NA NA NA hsa-miR-106b-5p TSC1 1.22477789913175 2.31787213143326e-32 -0.538880909055464 1.58533734753933e-21 miRNAWalker2_validate -0.137231047196163 5.24123367568988e-14 NA NA NA hsa-miR-148a-5p TSC1 0.572692271754695 2.14306251522796e-06 -0.538880909055464 1.58533734753933e-21 mirMAP -0.103146356844004 1.92663861875026e-10 NA NA NA hsa-miR-155-5p TSC1 1.09766314984151 4.55650930885814e-15 -0.538880909055464 1.58533734753933e-21 mirMAP -0.137386166665064 3.86179843967193e-24 NA NA NA hsa-miR-340-5p TSC1 1.0857159627596 4.94471062546756e-24 -0.538880909055464 1.58533734753933e-21 mirMAP -0.107750374208541 1.62313786574761e-09 NA NA NA hsa-miR-186-5p ULK1 -0.426987301460247 1.04129380549315e-05 0.460725843536286 3.10318710713242e-12 miRNAWalker2_validate -0.17046769755745 2.78940794650237e-13 NA NA NA hsa-miR-320a ULK1 -0.287921276129346 0.00141693637596294 0.460725843536286 3.10318710713242e-12 miRNAWalker2_validate;miRNATAP -0.103915522066312 4.36412962356477e-05 NA NA NA hsa-miR-92a-3p ULK1 -0.342420481092807 0.000732275969501111 0.460725843536286 3.10318710713242e-12 miRNATAP -0.120056110048964 9.47295013815248e-08 NA NA NA hsa-let-7i-5p ULK2 -0.333419326258177 3.56960810786801e-08 -0.375958333211797 2.89189077422925e-05 MirTarget -0.327008916955161 1.48191572598311e-10 NA NA NA hsa-miR-223-3p ULK2 -0.966406159689943 7.90612601654887e-12 -0.375958333211797 2.89189077422925e-05 MirTarget -0.122867487138845 1.04589382185593e-08 NA NA NA hsa-miR-485-3p ULK2 -0.866822427729628 4.5194665263492e-11 -0.375958333211797 2.89189077422925e-05 MirTarget;PITA -0.104498583778113 8.05066618236471e-06 NA NA NA hsa-miR-590-3p ULK2 1.27438512890514 1.03164723481469e-23 -0.375958333211797 2.89189077422925e-05 mirMAP -0.115905550580319 2.67023649359824e-06 NA NA NA hsa-miR-125a-5p ULK3 -0.635694700253268 3.6703235721638e-11 0.735573512973171 1.0601693976613e-25 PITA -0.16002458606949 2.84025611617709e-10 NA NA NA hsa-miR-125b-5p ULK3 -1.94393269763542 2.78180543229264e-58 0.735573512973171 1.0601693976613e-25 miRNAWalker2_validate -0.240994268158963 4.65849533746695e-40 NA NA NA hsa-miR-28-5p ULK3 -0.14267073663385 0.0497619246260571 0.735573512973171 1.0601693976613e-25 miRanda -0.126486106001449 0.000233852849670499 NA NA NA hsa-miR-491-5p ULK3 -1.04307210952796 1.14586501470398e-15 0.735573512973171 1.0601693976613e-25 miRanda -0.12645181986934 1.1755960141245e-11 NA NA NA hsa-miR-101-3p VEGFA -0.126035286271986 0.145997832808138 0.558196398264416 4.82412858140541e-08 miRNAWalker2_validate -0.244521682678937 1.84891665047835e-09 NA NA NA hsa-miR-134-5p VEGFA -0.943054080774898 1.50079821035544e-12 0.558196398264416 4.82412858140541e-08 miRNAWalker2_validate;miRTarBase;MirTarget -0.167128564426745 1.10726961805336e-10 NA NA NA hsa-miR-150-5p VEGFA -0.832049526091211 3.45299201139224e-05 0.558196398264416 4.82412858140541e-08 miRNAWalker2_validate;miRTarBase -0.151371862718652 1.00198904514709e-18 NA NA NA hsa-miR-195-5p VEGFA -1.47508108420708 2.20685847368258e-38 0.558196398264416 4.82412858140541e-08 miRNAWalker2_validate;miRTarBase;MirTarget -0.218575701645509 7.55403373439709e-14 27574422;23468064;26823724 In this study we used a new cationic peptide disulfide cross-linked stearylated polyarginine peptide modified with histidine H3R5 as a reducible vector cell penetrating peptide-modified aptamer ST21 with specific binding to HCC cells to conjugate to peptide H3R5 as the targeting probe miRNA-195 miR195 as a powerful gene drug to inhibit VEGF and fasudil to suppress vasculogenic mimicry by blocking ROCK2 all of which were simultaneously encapsulated in the same nanoparticles;Furthermore we revealed that miR-195 down-regulation resulted in enhanced VEGF levels in the tumor microenvironment which subsequently activated VEGF receptor 2 signaling in endothelial cells and thereby promoted angiogenesis;MiR 195 is a key negative regulator of hepatocellular carcinoma metastasis by targeting FGF2 and VEGFA; Luciferase reporter and ELISA assay prove that hematogenous metastasis related genes including FGF2 and VEGFA are the target genes of miR-195; Taken together our results suggest that miR-195 a tumor suppressor miRNA contributes to the lung metastasis of HCC by negatively regulating FGF2 and VEGFA providing key implications of miR-195 for the therapeutic intervention of HCC ;;metastasis liver cancer;liver cancer;liver cancer hsa-miR-199a-5p VEGFA -0.314703593105081 0.00909304983051124 0.558196398264416 4.82412858140541e-08 miRanda;miRNATAP -0.179279483927549 6.72134651164296e-10 25444917 In addition co-transfection with miR-199a mimic reversed the CCL5-mediated VEGF expression and angiogenesis in vitro and in vivo sarcoma hsa-miR-199b-5p VEGFA -1.37022396448377 3.25758057539223e-26 0.558196398264416 4.82412858140541e-08 miRanda -0.228409524155996 1.33793206666423e-18 NA NA NA hsa-miR-29a-3p VEGFA -0.699539666833076 1.13935003139957e-13 0.558196398264416 4.82412858140541e-08 MirTarget -0.114785243382774 0.00196474782587542 24209632 miR 29a suppresses growth and invasion of gastric cancer cells in vitro by targeting VEGF A; Furthermore western blot combined with the luciferase reporter assays demonstrate that vascular endothelial growth factor A VEGF-A is direct target of miR-29a; This is the first time miR-29a was found to suppress the tumor microvessel density in gastric cancer by targeting VEGF-A gastric cancer hsa-miR-29c-3p VEGFA -0.0652732378039769 0.563774115756922 0.558196398264416 4.82412858140541e-08 miRNAWalker2_validate;MirTarget -0.126355371943564 5.32172855437951e-05 NA NA NA hsa-miR-335-5p VEGFA -2.61355235628987 2.6462884165886e-51 0.558196398264416 4.82412858140541e-08 miRNAWalker2_validate -0.103950468396491 4.59347799365143e-08 NA NA NA hsa-miR-497-5p VEGFA -1.4667331575679 5.49909921822638e-36 0.558196398264416 4.82412858140541e-08 MirTarget -0.126722638387264 1.08881401780323e-05 26718330;26485685;26336827;26202364;27015364;25176450;26840372 Furthermore western blot assay confirmed that the overexpression of miR-497 reduced VEGF and HIF-1α protein levels; Moreover miR-497 inhibited the growth of tumors and reduced angiogenesis in a nude mouse xenograft tumor model which was probably caused by the downregulation of pro-angiogenic molecules such as VEGF and HIF-1α;Role of miR 497 in VEGF A mediated cancer cell growth and invasion in non small cell lung cancer; Here we showed that compared to other cancers NSCLC had a significant higher ratio of VEGF-A protein vs mRNA and significantly lower levels of miR-497 suggesting presence of a post-transcriptional control of VEGF-A in NSCLC different from other cancers; Compared with paired normal lung tissue NSCLC expressed lower levels of miR-497 and higher levels of VEGF-A; Moreover the levels of miR-497 and VEGF-A were inversely correlated in NSCLC specimen; Bioinformatics analyses showed that miR-497 bound to 3'-UTR of VEGF-A mRNA in NSCLC lines to inhibit its translation; Overexpression of miR-497 in NSCLC lines decreased VEGF-A protein while depletion of miR-497 in NSCLC lines increased VEGF-A protein; However modification of miR-497 levels in NSCLC lines did not alter VEGF-A mRNA levels;MiR 497 suppresses angiogenesis and metastasis of hepatocellular carcinoma by inhibiting VEGFA and AEG 1; Subsequent investigations disclosed that miR-497 directly inhibited the 3'-untranslated regions UTRs of vascular endothelial growth factor A VEGFA and astrocyte elevated gene-1 AEG-1;The effects of ectopic miR-497 expression on the expression of VEGFA Akt and p-Akt were determined by western blot; Luciferase reporter assay and western blot confirmed that VEGFA was a direct target of miR-497;Subsequent investigations disclosed that Twist was regulated by miR-497 directly leading to the increased level of Vascular Endothelial Growth Factor-A VEGFA;We further disclosed that miR-497 exerted its function of anti-angiogenesis by suppressing VEGFA expression in ovarian cancer cells and in turn impairing the VEGFR2-mediated PI3K/AKT and MAPK/ERK pathways;Vascular endothelial growth factor-A VEGF-A was confirmed to be a target of miR-497 ;;metastasis;;;; breast cancer;lung squamous cell cancer;liver cancer;sarcoma;pancreatic cancer;ovarian cancer;colorectal cancer hsa-miR-128-3p VEGFC 0.90296715955238 9.925204823863e-23 -0.815181679329146 2.46618490633351e-18 miRNAWalker2_validate;MirTarget -0.277923499247748 3.92415081523196e-16 25001183;26722309 Interestingly ectopic miR-128 overexpression could significantly inhibit vascular endothelial growth factor VEGF-C expression and reduce the activity of a luciferase reporter containing the VEGF-C 3'-untranslated region; These findings suggest that miR-128 could play a role in NSCLC tumourigenesis at least in part by modulation of angiogenesis and lymphangiogenesis through targeting VEGF-C and could simultaneously block ERK AKT and p38 signalling pathways;miR 128 downregulation promotes growth and metastasis of bladder cancer cells and involves VEGF C upregulation; To investigate the regulation of miR-128 on VEGF-C expression and their effects on proliferation and metastasis of bladder cancer T24 and 5637 BC cells were transfected with pre-miR-128 anti-miR-128 and their respective negative control; miR-128 was downregulated in BC tissues and cell lines while the expression levels of VEGF-C were upregulated; The present results indicated that miR-128 negatively regulated VEGF-C expression in BC T24 and 5637 BC cells; VEGF-C is a direct target of miR-128 in BC cells ;metastasis lung squamous cell cancer;bladder cancer hsa-miR-16-2-3p VEGFC 0.286355254959005 0.0256946046884474 -0.815181679329146 2.46618490633351e-18 MirTarget -0.165282903433736 7.39907917672124e-11 NA NA NA hsa-miR-590-3p VEGFC 1.27438512890514 1.03164723481469e-23 -0.815181679329146 2.46618490633351e-18 miRanda -0.194896362906364 4.34747156563496e-14 NA NA NA