miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-29b-3p ABL1 0.438847962603729 6.46722433236121e-05 -0.275680169504946 1.26034737385624e-07 miRNATAP -0.150093657310066 4.97592840467e-21 NA NA NA hsa-miR-30e-5p ABL1 0.293491764699475 0.000372291967271834 -0.275680169504946 1.26034737385624e-07 MirTarget;miRNATAP -0.118450960397299 5.04005203445343e-08 NA NA NA hsa-miR-140-3p ANAPC1 -1.25844395244141 5.29222651039892e-33 -0.309222995460143 0.000128266884668483 MirTarget -0.104622131939411 3.65968310694242e-05 NA NA NA hsa-miR-100-5p ANAPC11 -1.89453309391092 5.00588682382388e-51 1.17061641525475 1.39726427968068e-29 miRNAWalker2_validate -0.299938108438144 9.91819855796831e-30 NA NA NA hsa-miR-146b-5p ANAPC13 0.631041661167954 6.20366593452965e-08 0.0841261991322293 0.145924144453005 miRanda -0.134381548641463 5.44181251975856e-16 NA NA NA hsa-miR-139-5p ANAPC7 -3.25846663863766 2.62018989415003e-112 0.550641679190882 1.29069564317652e-28 miRanda -0.123681144516392 2.20881098673168e-34 NA NA NA hsa-miR-181a-5p ATM 0.635863607630183 6.72486918157744e-11 -0.753520785022149 8.14866377341274e-18 miRNAWalker2_validate;miRTarBase;MirTarget -0.212080382902989 6.50305312230929e-12 21102523;23656790;24531888;27150990;26113450 Ataxia telangiectasia mutated ATM a target gene of miR-181 exhibited reduced expression in mammospheres and upon TGF-β treatment;We report that miR-181a and miR-181b were overexpressed in more aggressive breast cancers and their expression correlates inversely with ATM levels;Ataxia-telangiectasia mutation ATM was predicted as a target gene of miR-181a with bioinformatics analysis and was verified by lucifersae reporter assay; A luciferase reporter assay demonstrated that ATM was a direct target of miR-181a miR-181a mimics transfection down regulated ATM mRNA and protein expression; There was inverse correlation between miR-181a and ATM protein expression in gastric cancer and normal gastric tissues; Our study demonstrates that over-expression of miR-181a might be involved in development of gastric cancer by promoting proliferation and inhibiting apoptosis probably through directly targeting ATM miR-181a modulation may be a potential strategy for the development of miRNA-based therapy of gastric cancer;MiR 181a Promotes Proliferation of Human Acute Myeloid Leukemia Cells by Targeting ATM; Dual luciferase reporter gene assay showed that miR-181a significantly suppressed the reporter gene activity containing ATM 3'-UTR by about 56.8% P < 0.05 but it didn't suppress the reporter gene activity containing 3'-UTR ATM mutation; Western blot showed that miR-181a significantly downregulated the expression of ATM in human leukemia cells; It is also found that miR-181a was significantly increased in AML which showed a negative correlation with ATM expression; miR-181a promotes cell proliferation in AML by regulating the tumor suppressor ATM thus it plays the role as oncogene in pathogenesis of AML;miR 181a promotes G1/S transition and cell proliferation in pediatric acute myeloid leukemia by targeting ATM; Pediatric AML patients and healthy controls were enrolled and the expression of miR-181a and ataxia telangiectasia mutated ATM in tissues were examined using quantitative PCR; Moreover cell proliferation and cell cycle were evaluated in several cell lines HL60 NB4 and K562 by using flow cytometry after transfected with miR-181a mimics and inhibitors or ATM siRNA and control siRNA; Finally ATM as the potential target protein of miR-181a was examined; We found that miR-181a was significantly increased in pediatric AML which showed an inverse association with ATM expression; Luciferase activity of the reporter construct identified ATM as the direct molecular target of miR-181a; The results revealed novel mechanism through which miR-181a regulates G1/S transition and cell proliferation in pediatric AML by regulating the tumor suppressor ATM providing insights into the molecular mechanism in pediatric AML ;;;; breast cancer;breast cancer;gastric cancer;acute myeloid leukemia;acute myeloid leukemia hsa-miR-181b-5p ATM 1.22749257795094 1.21998198830919e-27 -0.753520785022149 8.14866377341274e-18 MirTarget -0.217803705013907 3.99505534670018e-17 21102523;23656790 Ataxia telangiectasia mutated ATM a target gene of miR-181 exhibited reduced expression in mammospheres and upon TGF-β treatment;We report that miR-181a and miR-181b were overexpressed in more aggressive breast cancers and their expression correlates inversely with ATM levels ; breast cancer;breast cancer hsa-miR-181d-5p ATM 0.782618466877349 1.2821116358212e-09 -0.753520785022149 8.14866377341274e-18 MirTarget -0.119716083515509 3.28179905476897e-07 NA NA NA hsa-miR-18a-5p ATM 0.969066793715868 1.69069796425892e-08 -0.753520785022149 8.14866377341274e-18 miRNAWalker2_validate;miRTarBase;MirTarget -0.116309277677122 3.16867464269194e-11 23857602;23437304;25963391;23229340 Furthermore we used antisense oligonucleotides against micro RNAs miRNA or miRNA overexpression plasmids to study the role of miR-18a and -106a on ATM expression; Furthermore we identified that ERα activates miR-18a and -106a to downregulate ATM expression; We reveal a novel mechanism involving ERα and miR-18a and -106a regulation of ATM in breast cancer;MicroRNA 18a attenuates DNA damage repair through suppressing the expression of ataxia telangiectasia mutated in colorectal cancer; Through in silico search the 3'UTR of Ataxia telangiectasia mutated ATM contains a conserved miR-18a binding site; Expression of ATM was down-regulated in CRC tumors p<0.0001 and inversely correlated with miR-18a expression r = -0.4562 p<0.01; This was further confirmed by the down-regulation of ATM protein by miR-18a; As ATM is a key enzyme in DNA damage repair we evaluated the effect of miR-18a on DNA double-strand breaks; miR-18a attenuates cellular repair of DNA double-strand breaks by directly suppressing ATM a key enzyme in DNA damage repair;However the upregulation of miR-18a suppressed the level of ataxia-telangiectasia mutated and attenuated DNA double-strand break repair after irradiation which re-sensitized the cervical cancer cells to radiotherapy by promoting apoptosis;MicroRNA 18a upregulates autophagy and ataxia telangiectasia mutated gene expression in HCT116 colon cancer cells; Previous studies showed that certain microRNAs including miR-18a potentially regulate ATM in cancer cells; However the mechanisms behind the modulation of ATM by miR-18a remain to be elucidated in colon cancer cells; In the present study we explored the impact of miR-18a on the autophagy process and ATM expression in HCT116 colon cancer cells; Western blotting and luciferase assays were implemented to explore the impact of miR-18a on ATM gene expression in HCT116 cells; Moreover miR-18a overexpression led to the upregulation of ATM expression and suppression of mTORC1 activity; Results of the present study pertaining to the role of miR-18a in regulating autophagy and ATM gene expression in colon cancer cells revealed a novel function for miR-18a in a critical cellular event and on a crucial gene with significant impacts in cancer development progression treatment and in other diseases ;;;progression breast cancer;colorectal cancer;cervical and endocervical cancer;colon cancer hsa-miR-21-5p ATM 2.32007501846389 3.08394781855554e-137 -0.753520785022149 8.14866377341274e-18 mirMAP -0.230974664847653 3.0596374789676e-17 26289851 MiR-21 is an oncomiR that is overexpressed in nearly all cancers including ATC; Hence suppression of miR-21 could pave the way for ATC therapy thyroid cancer hsa-miR-140-3p ATR -1.25844395244141 5.29222651039892e-33 -0.182962371066174 0.00500352198780384 PITA -0.137096483152858 1.22829525488745e-11 NA NA NA hsa-miR-361-5p ATR -0.0996867547900457 0.095428250126326 -0.182962371066174 0.00500352198780384 miRanda -0.243676561927317 9.34381314288267e-11 NA NA NA hsa-miR-374a-5p ATR -0.239709888246804 0.00309819667153627 -0.182962371066174 0.00500352198780384 mirMAP -0.105234691946044 0.000143287219478725 NA NA NA hsa-miR-10b-3p BUB1 -1.58463104907636 1.17335119858099e-46 3.58074914300466 1.00791550985226e-91 MirTarget -0.878199089674969 1.75749570824449e-59 NA NA NA hsa-miR-139-5p BUB1 -3.25846663863766 2.62018989415003e-112 3.58074914300466 1.00791550985226e-91 miRanda -0.676658906458606 4.07397826149591e-74 NA NA NA hsa-miR-199a-5p BUB1 -0.314703593105081 0.00909304983051124 3.58074914300466 1.00791550985226e-91 miRanda -0.379875637571143 8.940147103743e-12 NA NA NA hsa-miR-199b-5p BUB1 -1.37022396448377 3.25758057539223e-26 3.58074914300466 1.00791550985226e-91 miRanda -0.585396180044347 5.43809057637023e-33 NA NA NA hsa-miR-495-3p BUB1 -1.67685437612894 1.70634429769052e-34 3.58074914300466 1.00791550985226e-91 MirTarget -0.420726724241678 2.02172635074258e-19 NA NA NA hsa-miR-653-5p BUB1 -0.331768344796534 0.0202141592764062 3.58074914300466 1.00791550985226e-91 MirTarget -0.192796772289622 4.85058869636607e-05 NA NA NA hsa-miR-215-5p BUB1B -1.35643065897947 2.3180023440257e-20 3.23445091135015 9.85826919015158e-87 miRNAWalker2_validate -0.118069268648432 0.0047805913842163 NA NA NA hsa-miR-22-3p BUB1B -0.505819481364718 1.90494905330622e-13 3.23445091135015 9.85826919015158e-87 miRNAWalker2_validate -0.414185767254408 4.7567793730382e-06 NA NA NA hsa-miR-486-5p BUB1B -3.87258704301474 1.22658629378451e-80 3.23445091135015 9.85826919015158e-87 miRanda -0.326934382418176 1.3721748065016e-34 NA NA NA hsa-miR-139-5p BUB3 -3.25846663863766 2.62018989415003e-112 0.935337217612312 2.05561051785776e-37 miRanda -0.187467052732184 2.23759413543203e-35 NA NA NA hsa-let-7b-3p CCNA2 -0.778498268330274 1.04357662300776e-10 2.73230807661792 1.49184563825378e-66 MirTarget -0.242769809139884 5.19572964887948e-07 NA NA NA hsa-let-7b-5p CCNA2 -0.54215483448257 7.21347617597858e-08 2.73230807661792 1.49184563825378e-66 miRNAWalker2_validate;miRTarBase -0.520606668002535 9.82700117143091e-20 NA NA NA hsa-miR-199a-5p CCNA2 -0.314703593105081 0.00909304983051124 2.73230807661792 1.49184563825378e-66 miRanda -0.375301774827009 7.94784689554601e-15 NA NA NA hsa-miR-199b-5p CCNA2 -1.37022396448377 3.25758057539223e-26 2.73230807661792 1.49184563825378e-66 miRanda -0.499350873276725 1.37673760507688e-31 NA NA NA hsa-miR-218-5p CCNA2 -1.02621788318234 2.9221925445771e-23 2.73230807661792 1.49184563825378e-66 MirTarget -0.487900429011924 4.77951072370678e-19 NA NA NA hsa-miR-22-3p CCNA2 -0.505819481364718 1.90494905330622e-13 2.73230807661792 1.49184563825378e-66 MirTarget -0.251101373734703 0.00338841385391072 25596928 The sequence of miR-22 which is conserved in mice rats humans and other mammalians aligns with the sequence of 3'-UTR of CCNA2; Chenodeoxycholic acid treatment and miR-22 mimics reduced CCNA2 protein and increased the number of G0/G1 Huh7 and HCT116 cells; In humans the expression levels of miR-22 and CCNA2 are inversely correlated in liver and colon cancers liver cancer hsa-miR-29a-3p CCNA2 -0.699539666833076 1.13935003139957e-13 2.73230807661792 1.49184563825378e-66 MirTarget -0.451006935599481 1.83051653651677e-13 NA NA NA hsa-miR-29c-3p CCNA2 -0.0652732378039769 0.563774115756922 2.73230807661792 1.49184563825378e-66 MirTarget -0.434580902546846 3.27850778209015e-17 NA NA NA hsa-miR-320a CCNA2 -0.287921276129346 0.00141693637596294 2.73230807661792 1.49184563825378e-66 miRanda -0.207497263851829 0.00159927266524122 NA NA NA hsa-miR-34c-5p CCNA2 -0.0896438810345765 0.557016551646841 2.73230807661792 1.49184563825378e-66 miRanda -0.289476857442162 4.60188252682273e-14 NA NA NA hsa-miR-486-5p CCNA2 -3.87258704301474 1.22658629378451e-80 2.73230807661792 1.49184563825378e-66 miRanda -0.262023712888287 7.82983896231198e-25 NA NA NA hsa-let-7b-5p CCNB1 -0.54215483448257 7.21347617597858e-08 2.41596782139125 1.64230288731479e-82 miRNAWalker2_validate -0.394935930328456 1.73247776867955e-17 NA NA NA hsa-miR-139-5p CCNB1 -3.25846663863766 2.62018989415003e-112 2.41596782139125 1.64230288731479e-82 miRanda -0.48632264255974 6.28227602164649e-78 NA NA NA hsa-miR-140-5p CCNB1 -0.755971041589807 9.68060922934542e-14 2.41596782139125 1.64230288731479e-82 miRanda -0.151189526798117 0.00114311498286806 NA NA NA hsa-let-7a-5p CCNB2 -0.210286642041636 0.0072546234707717 3.43292983356506 4.14076853090613e-90 miRNAWalker2_validate -0.621192649278321 7.7996632083381e-14 NA NA NA hsa-let-7b-5p CCNB2 -0.54215483448257 7.21347617597858e-08 3.43292983356506 4.14076853090613e-90 miRNAWalker2_validate -0.541022811667963 1.91496765651017e-17 NA NA NA hsa-let-7c-5p CCNB2 -1.9415540533505 9.55250745007793e-48 3.43292983356506 4.14076853090613e-90 miRNAWalker2_validate -0.663845253967336 3.73074325919323e-53 NA NA NA hsa-let-7i-5p CCND1 -0.333419326258177 3.56960810786801e-08 0.789100261201456 1.48424202389562e-06 miRNATAP -0.759700962013673 2.31065071397228e-16 NA NA NA hsa-miR-106a-5p CCND1 0.574594373206545 0.000145868284001732 0.789100261201456 1.48424202389562e-06 MirTarget;miRNATAP -0.174359830876255 2.65007775906387e-06 NA NA NA hsa-miR-106b-5p CCND1 1.22477789913175 2.31787213143326e-32 0.789100261201456 1.48424202389562e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.258644062815507 8.24041501542474e-07 NA NA NA hsa-miR-142-3p CCND1 1.53951237846104 2.06769936282034e-17 0.789100261201456 1.48424202389562e-06 miRanda -0.111966511365121 0.000240262100008297 23619912 Transfection of miR-142-3p mimics in colon cancer cells downregulated cyclin D1 expression induced G1 phase cell cycle arrest and elevated the sensitivity of the cells to 5-fluorouracil colon cancer hsa-miR-142-5p CCND1 1.16509303143593 1.96641162209073e-13 0.789100261201456 1.48424202389562e-06 PITA -0.210173449112337 1.63510921192815e-09 NA NA NA hsa-miR-150-5p CCND1 -0.832049526091211 3.45299201139224e-05 0.789100261201456 1.48424202389562e-06 mirMAP -0.187252742453937 1.34917625164856e-11 NA NA NA hsa-miR-155-5p CCND1 1.09766314984151 4.55650930885814e-15 0.789100261201456 1.48424202389562e-06 miRNAWalker2_validate -0.298681895389198 2.32439253453393e-14 26955820 MicroRNA 155 expression inversely correlates with pathologic stage of gastric cancer and it inhibits gastric cancer cell growth by targeting cyclin D1 staging gastric cancer hsa-miR-15b-5p CCND1 0.788659356634696 1.13678211092534e-11 0.789100261201456 1.48424202389562e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.125463191460891 0.00921827566968511 NA NA NA hsa-miR-17-5p CCND1 0.599531757298529 1.07318660415906e-05 0.789100261201456 1.48424202389562e-06 miRNAWalker2_validate;MirTarget;TargetScan;miRNATAP -0.23795787679729 6.72139201694027e-09 26431674 Bioinformatics Prediction and In Vitro Analysis Revealed That miR 17 Targets Cyclin D1 mRNA in Triple Negative Breast Cancer Cells; In this study using bioinformatic analyses miR-17 was selected as it targets the 3'UTR of CCND1 gene with the highest score; After lentiviral transduction of miR-17 to the target cells gene expression analysis showed decreased expression of CCND1 gene breast cancer hsa-miR-186-5p CCND1 -0.426987301460247 1.04129380549315e-05 0.789100261201456 1.48424202389562e-06 mirMAP -0.494988902443749 5.18517439622754e-18 NA NA NA hsa-miR-19a-3p CCND1 0.817507952171848 3.76285090469625e-08 0.789100261201456 1.48424202389562e-06 miRNAWalker2_validate;miRTarBase;miRNATAP -0.216023850578105 8.24189814452405e-09 25985117 Moreover miR-19a might play inhibitory roles in HCC malignancy via regulating Cyclin D1 expression liver cancer hsa-miR-19b-1-5p CCND1 0.647704962003062 3.07687667945597e-07 0.789100261201456 1.48424202389562e-06 miRNAWalker2_validate;miRTarBase -0.206802040114629 3.03348057195458e-06 NA NA NA hsa-miR-19b-3p CCND1 0.139124391010031 0.255658553872934 0.789100261201456 1.48424202389562e-06 miRNATAP -0.249444343540709 5.93160032007176e-08 NA NA NA hsa-miR-20a-5p CCND1 0.44979911120222 0.000602386964327228 0.789100261201456 1.48424202389562e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.218045690926451 3.58399990050218e-07 NA NA NA hsa-miR-23b-3p CCND1 -0.363202401123049 0.000265305319764878 0.789100261201456 1.48424202389562e-06 miRNATAP -0.2085521275068 0.000237936656088415 NA NA NA hsa-miR-29a-3p CCND1 -0.699539666833076 1.13935003139957e-13 0.789100261201456 1.48424202389562e-06 mirMAP -0.358623457755512 1.12263469726765e-09 NA NA NA hsa-miR-340-5p CCND1 1.0857159627596 4.94471062546756e-24 0.789100261201456 1.48424202389562e-06 mirMAP -0.157803294541288 0.00210629660665075 NA NA NA hsa-miR-374a-5p CCND1 -0.239709888246804 0.00309819667153627 0.789100261201456 1.48424202389562e-06 MirTarget -0.556352001430099 7.67413515717595e-16 27191497 microRNA 374a suppresses colon cancer progression by directly reducing CCND1 to inactivate the PI3K/AKT pathway; Furthermore luciferase reporter assays confirmed that miR-374a could directly reduce CCND1; We examined miR-374a levels by in situ hybridization and its correlation with CCND1 expression in CRC tumor tissues; High miR-374a expression with low level of CCND1 was protective factor in CRC; Together these findings indicate that miR-374a inactivates the PI3K/AKT axis by inhibiting CCND1 suppressing of colon cancer progression progression colon cancer hsa-miR-374b-5p CCND1 -0.466781429946153 1.17238311619116e-08 0.789100261201456 1.48424202389562e-06 miRNAWalker2_validate;MirTarget -0.531193112029599 5.3445494840887e-15 NA NA NA hsa-miR-424-5p CCND1 0.420789584199235 0.00480101660479489 0.789100261201456 1.48424202389562e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.165346668007668 1.17175782770906e-05 NA NA NA hsa-miR-495-3p CCND1 -1.67685437612894 1.70634429769052e-34 0.789100261201456 1.48424202389562e-06 MirTarget -0.2655760978611 1.39010362325337e-11 NA NA NA hsa-miR-511-5p CCND1 -2.27545475897362 3.84085514050558e-36 0.789100261201456 1.48424202389562e-06 MirTarget -0.21938803198833 1.27831310404617e-13 NA NA NA hsa-miR-589-3p CCND1 0.0263457630961427 0.866577983997705 0.789100261201456 1.48424202389562e-06 MirTarget -0.116809863299678 0.00155105242627909 NA NA NA hsa-miR-590-3p CCND1 1.27438512890514 1.03164723481469e-23 0.789100261201456 1.48424202389562e-06 mirMAP -0.221641713536578 8.94498108920728e-07 NA NA NA hsa-miR-9-5p CCND1 0.734772328078424 0.00261982843636383 0.789100261201456 1.48424202389562e-06 miRNAWalker2_validate -0.162121975003827 1.12937727530253e-12 NA NA NA hsa-miR-92a-3p CCND1 -0.342420481092807 0.000732275969501111 0.789100261201456 1.48424202389562e-06 miRNAWalker2_validate -0.355039027931141 1.3665845638516e-10 NA NA NA hsa-miR-93-5p CCND1 1.01788600209314 1.24312921618126e-21 0.789100261201456 1.48424202389562e-06 miRNAWalker2_validate;MirTarget;miRNATAP -0.160469090487963 0.00197437840989499 NA NA NA hsa-miR-942-5p CCND1 0.0274758353801279 0.842368857038259 0.789100261201456 1.48424202389562e-06 MirTarget -0.261175156275166 1.39422778172566e-10 NA NA NA hsa-let-7a-3p CCND2 0.466622567891891 3.70886257943079e-07 -1.32381712777542 1.10807863083966e-33 mirMAP -0.215275364862757 3.63993039775257e-07 20418948 MicroRNA let 7a inhibits proliferation of human prostate cancer cells in vitro and in vivo by targeting E2F2 and CCND2 prostate cancer hsa-let-7e-5p CCND2 0.261471269338985 0.00191077095550257 -1.32381712777542 1.10807863083966e-33 miRNATAP -0.168033346737038 0.000309648297817392 NA NA NA hsa-miR-106a-5p CCND2 0.574594373206545 0.000145868284001732 -1.32381712777542 1.10807863083966e-33 miRNATAP -0.117204496646304 5.04333413242193e-06 NA NA NA hsa-miR-106b-5p CCND2 1.22477789913175 2.31787213143326e-32 -1.32381712777542 1.10807863083966e-33 miRNAWalker2_validate;miRTarBase;miRNATAP -0.324304654054346 9.75129599972944e-20 NA NA NA hsa-miR-130b-5p CCND2 1.0573161199584 2.55177349228739e-12 -1.32381712777542 1.10807863083966e-33 mirMAP -0.113060251982174 8.9777676148938e-06 NA NA NA hsa-miR-141-3p CCND2 2.99777540204168 1.26370498493024e-78 -1.32381712777542 1.10807863083966e-33 MirTarget;TargetScan -0.300723945575078 8.35441899721039e-47 NA NA NA hsa-miR-151a-3p CCND2 0.3530403796941 3.45015092968892e-05 -1.32381712777542 1.10807863083966e-33 mirMAP -0.17767569994557 0.000108302525662849 NA NA NA hsa-miR-15a-5p CCND2 0.812445324157528 4.50263417099822e-20 -1.32381712777542 1.10807863083966e-33 miRNAWalker2_validate;miRTarBase;miRNATAP -0.382989347535057 1.85935181542133e-19 NA NA NA hsa-miR-15b-5p CCND2 0.788659356634696 1.13678211092534e-11 -1.32381712777542 1.10807863083966e-33 miRNATAP -0.200863767053961 1.18885859507843e-09 NA NA NA hsa-miR-16-5p CCND2 0.46835991343556 1.91125356547776e-06 -1.32381712777542 1.10807863083966e-33 miRNAWalker2_validate;miRNATAP -0.126011969570663 0.00149555991801246 NA NA NA hsa-miR-17-5p CCND2 0.599531757298529 1.07318660415906e-05 -1.32381712777542 1.10807863083966e-33 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.218141508896336 9.56625930755479e-15 NA NA NA hsa-miR-182-5p CCND2 2.36408084103818 2.60011457600281e-72 -1.32381712777542 1.10807863083966e-33 miRNAWalker2_validate;miRTarBase;miRNATAP -0.333755066801542 7.98233999507297e-38 NA NA NA hsa-miR-183-5p CCND2 2.95681814393872 1.09965777344285e-92 -1.32381712777542 1.10807863083966e-33 miRNATAP -0.301857921065621 1.16754966176673e-39 NA NA NA hsa-miR-185-5p CCND2 0.482334746589337 3.68475879959415e-09 -1.32381712777542 1.10807863083966e-33 MirTarget;miRNATAP -0.252091965164496 1.07493887045353e-07 NA NA NA hsa-miR-191-5p CCND2 0.831652724468215 1.98847993606895e-12 -1.32381712777542 1.10807863083966e-33 MirTarget -0.190841372088135 4.05600831845751e-09 NA NA NA hsa-miR-19a-3p CCND2 0.817507952171848 3.76285090469625e-08 -1.32381712777542 1.10807863083966e-33 MirTarget;miRNATAP -0.185131062383478 6.94387115240903e-13 NA NA NA hsa-miR-19b-3p CCND2 0.139124391010031 0.255658553872934 -1.32381712777542 1.10807863083966e-33 miRNAWalker2_validate;MirTarget;miRNATAP -0.166767747836903 1.62862778749919e-07 NA NA NA hsa-miR-200a-3p CCND2 2.55218480823434 2.96135446816238e-51 -1.32381712777542 1.10807863083966e-33 MirTarget -0.261226562912324 4.31939405604759e-36 NA NA NA hsa-miR-20a-5p CCND2 0.44979911120222 0.000602386964327228 -1.32381712777542 1.10807863083966e-33 miRNAWalker2_validate;miRTarBase;miRNATAP -0.235095611327971 1.01223581717651e-15 NA NA NA hsa-miR-20b-5p CCND2 0.78236583455125 8.7938334801223e-05 -1.32381712777542 1.10807863083966e-33 miRNATAP -0.104708964184932 6.77204420924901e-08 NA NA NA hsa-miR-21-3p CCND2 2.17476065946878 5.15299442583591e-75 -1.32381712777542 1.10807863083966e-33 mirMAP -0.127404398971718 2.08059143790106e-05 NA NA NA hsa-miR-29b-3p CCND2 0.438847962603729 6.46722433236121e-05 -1.32381712777542 1.10807863083966e-33 MirTarget;miRNATAP -0.166630108966211 2.5453033344596e-06 22330340;24130168 In addition to CCND2 miR-29 also targets E2F7 another cell cycle regulator;We further demonstrated that miR-29 family acted as tumor suppressors through targeting CCND2 and matrix metalloproteinase-2 genes in GC ; sarcoma;gastric cancer hsa-miR-301a-3p CCND2 1.32170168375632 2.12280368957514e-15 -1.32381712777542 1.10807863083966e-33 miRNAWalker2_validate -0.182363632693643 1.4299291622836e-15 NA NA NA hsa-miR-3065-3p CCND2 1.62787885002468 6.81477830005026e-19 -1.32381712777542 1.10807863083966e-33 MirTarget;miRNATAP -0.215305118861858 1.68654607913855e-26 NA NA NA hsa-miR-30d-3p CCND2 0.264544633563642 0.00755023189129747 -1.32381712777542 1.10807863083966e-33 mirMAP -0.277305057640272 1.40644960106378e-12 NA NA NA hsa-miR-320b CCND2 0.412787504747938 0.00113457276903985 -1.32381712777542 1.10807863083966e-33 mirMAP;miRNATAP -0.105338094438455 0.000662995774848357 NA NA NA hsa-miR-324-3p CCND2 0.404877731996915 0.000340036423920834 -1.32381712777542 1.10807863083966e-33 miRNAWalker2_validate -0.187482582074807 4.91214943402943e-08 NA NA NA hsa-miR-331-5p CCND2 0.682437632502949 4.10871642662371e-11 -1.32381712777542 1.10807863083966e-33 miRNATAP -0.224823939820064 1.69348201302645e-09 NA NA NA hsa-miR-342-3p CCND2 1.21944481975657 6.81914373001202e-19 -1.32381712777542 1.10807863083966e-33 miRNAWalker2_validate;mirMAP -0.103848624831325 0.000189231379572542 NA NA NA hsa-miR-429 CCND2 2.84108892259147 3.88520896426515e-64 -1.32381712777542 1.10807863083966e-33 miRNATAP -0.232180070081619 1.04111918722712e-28 NA NA NA hsa-miR-590-3p CCND2 1.27438512890514 1.03164723481469e-23 -1.32381712777542 1.10807863083966e-33 miRanda;mirMAP -0.13833737728579 9.4871454586344e-06 NA NA NA hsa-miR-590-5p CCND2 0.746515607868274 8.51300479640125e-09 -1.32381712777542 1.10807863083966e-33 mirMAP -0.151134124586935 3.93710909950627e-07 NA NA NA hsa-miR-660-5p CCND2 0.406910761707485 0.000156175371762464 -1.32381712777542 1.10807863083966e-33 mirMAP -0.106401121539045 0.00339848496849202 NA NA NA hsa-miR-7-1-3p CCND2 0.686579567507582 1.20731554448806e-07 -1.32381712777542 1.10807863083966e-33 mirMAP -0.138929082076826 3.22847149980611e-06 NA NA NA hsa-miR-93-5p CCND2 1.01788600209314 1.24312921618126e-21 -1.32381712777542 1.10807863083966e-33 miRNATAP -0.400435186075896 5.37578279205249e-31 NA NA NA hsa-miR-96-5p CCND2 3.24596558166606 1.92296159041707e-98 -1.32381712777542 1.10807863083966e-33 TargetScan;miRNATAP -0.311897703713413 7.58506265459077e-49 NA NA NA hsa-miR-125b-5p CCNE1 -1.94393269763542 2.78180543229264e-58 2.02272205094151 6.47439339208807e-27 miRNAWalker2_validate -0.382224070637194 4.63212335978261e-14 NA NA NA hsa-miR-195-5p CCNE1 -1.47508108420708 2.20685847368258e-38 2.02272205094151 6.47439339208807e-27 miRNAWalker2_validate;MirTarget;miRNATAP -0.617319346276305 3.09483424185554e-30 24402230 Furthermore through qPCR and western blot assays we showed that overexpression of miR-195-5p reduced CCNE1 mRNA and protein levels respectively breast cancer hsa-miR-26a-5p CCNE1 -0.481180084102235 1.82368246174758e-10 2.02272205094151 6.47439339208807e-27 miRNAWalker2_validate;miRTarBase;miRNATAP -0.619294201366171 1.19374874415568e-12 22094936 Cell cycle regulation and CCNE1 and CDC2 were the only significant overlapping pathway and genes differentially expressed between tumors with high and low levels of miR-26a and EZH2 respectively; Low mRNA levels of EZH2 CCNE1 and CDC2 and high levels of miR-26a are associated with favorable outcome on tamoxifen breast cancer hsa-miR-26b-5p CCNE1 -0.331527896896866 0.000551258576575092 2.02272205094151 6.47439339208807e-27 miRNAWalker2_validate;miRTarBase;miRNATAP -0.319970519742405 4.01394740915552e-06 NA NA NA hsa-miR-342-5p CCNE1 1.49554286219821 1.56221300255782e-22 2.02272205094151 6.47439339208807e-27 miRNAWalker2_validate -0.135292830202672 0.00141592689314045 NA NA NA hsa-miR-497-5p CCNE1 -1.4667331575679 5.49909921822638e-36 2.02272205094151 6.47439339208807e-27 MirTarget;miRNATAP -0.382195878498221 1.36469362381851e-12 24112607;25909221;24909281 Western blot assays confirmed that overexpression of miR-497 reduced cyclin E1 protein levels; Inhibited cellular growth suppressed cellular migration and invasion and G1 cell cycle arrest were observed upon overexpression of miR-497 in cells possibly by targeting cyclin E1;The effect of simultaneous overexpression of miR-497 and miR-34a on the inhibition of cell proliferation colony formation and tumor growth and the downregulation of cyclin E1 was stronger than the effect of each miRNA alone; The synergistic actions of miR-497 and miR-34a partly correlated with cyclin E1 levels; These results indicate cyclin E1 is downregulated by both miR-497 and miR-34a which synergistically retard the growth of human lung cancer cells;miR 497 suppresses proliferation of human cervical carcinoma HeLa cells by targeting cyclin E1; Furthermore the target effect of miR-497 on the CCNE1 was identified by dual-luciferase reporter assay system qRT-PCR and Western blotting; Over-expressed miR-497 in HeLa cells could suppress cell proliferation by targeting CCNE1 ;; breast cancer;lung cancer;cervical and endocervical cancer hsa-miR-26a-5p CCNE2 -0.481180084102235 1.82368246174758e-10 2.57138773577447 1.5602638336465e-57 miRNAWalker2_validate;miRTarBase;miRNATAP -0.630654803219519 2.81902449356968e-16 24116110;21901171 The loss of miR 26a mediated post transcriptional regulation of cyclin E2 in pancreatic cancer cell proliferation and decreased patient survival; The in vitro and in vivo assays showed that overexpression of miR-26a resulted in cell cycle arrest inhibited cell proliferation and decreased tumor growth which was associated with cyclin E2 downregulation;We also show that enforced expression of miR-26a in AML cells is able to inhibit cell cycle progression by downregulating cyclin E2 expression poor survival;progression pancreatic cancer;acute myeloid leukemia hsa-miR-28-3p CCNE2 -0.815347900986328 3.29387468083828e-30 2.57138773577447 1.5602638336465e-57 PITA;miRNATAP -0.332464341790485 3.74937420435342e-05 NA NA NA hsa-miR-30a-5p CCNE2 -0.392489994825279 0.00954894667761676 2.57138773577447 1.5602638336465e-57 miRNATAP -0.389839068904493 1.17236295202714e-24 NA NA NA hsa-miR-30c-5p CCNE2 -0.393222674580066 8.06961465717306e-05 2.57138773577447 1.5602638336465e-57 miRNATAP -0.253921413883948 1.85400203918647e-05 NA NA NA hsa-miR-335-3p CCNE2 -1.88448538773649 2.09538234398335e-32 2.57138773577447 1.5602638336465e-57 mirMAP -0.16561143561413 3.48668881373491e-06 NA NA NA hsa-miR-34c-5p CCNE2 -0.0896438810345765 0.557016551646841 2.57138773577447 1.5602638336465e-57 miRNAWalker2_validate;miRTarBase;PITA;miRanda;miRNATAP -0.253783325617594 5.10732275535071e-11 NA NA NA hsa-miR-1301-3p CCNH 1.80754972811286 2.96809840886499e-36 -0.354892854139323 3.73242603547919e-09 miRNAWalker2_validate -0.100610978156191 1.62212068254518e-13 NA NA NA hsa-miR-142-5p CCNH 1.16509303143593 1.96641162209073e-13 -0.354892854139323 3.73242603547919e-09 PITA -0.106455414274994 4.6821342336756e-17 NA NA NA hsa-miR-590-3p CCNH 1.27438512890514 1.03164723481469e-23 -0.354892854139323 3.73242603547919e-09 miRanda -0.113790889441791 4.79174587409921e-12 NA NA NA hsa-miR-141-3p CDC14A 2.99777540204168 1.26370498493024e-78 -1.23414445517375 6.16820708163778e-16 TargetScan;miRNATAP -0.136888602907261 5.43142578436724e-06 NA NA NA hsa-miR-148a-3p CDC14A 0.706969798912638 5.52538085480485e-09 -1.23414445517375 6.16820708163778e-16 miRNATAP -0.195143961324034 7.18646547844781e-06 NA NA NA hsa-miR-148a-5p CDC14A 0.572692271754695 2.14306251522796e-06 -1.23414445517375 6.16820708163778e-16 mirMAP -0.190229665599538 1.40265259399761e-05 NA NA NA hsa-miR-200a-3p CDC14A 2.55218480823434 2.96135446816238e-51 -1.23414445517375 6.16820708163778e-16 miRNATAP -0.100138641411013 0.000721104667858655 NA NA NA hsa-miR-429 CDC14A 2.84108892259147 3.88520896426515e-64 -1.23414445517375 6.16820708163778e-16 miRanda -0.151181616097811 2.42780972015926e-07 NA NA NA hsa-miR-493-5p CDC14A 1.25321217062116 2.58094342947875e-18 -1.23414445517375 6.16820708163778e-16 miRNATAP -0.107669129001657 0.00330527562515068 NA NA NA hsa-miR-590-3p CDC14A 1.27438512890514 1.03164723481469e-23 -1.23414445517375 6.16820708163778e-16 PITA;miRanda;mirMAP;miRNATAP -0.14670575746951 0.000585837319886673 NA NA NA hsa-let-7a-3p CDC14B 0.466622567891891 3.70886257943079e-07 -2.02470757063903 5.50090046332077e-71 miRNATAP -0.189473573552147 4.18926703459698e-05 NA NA NA hsa-miR-141-3p CDC14B 2.99777540204168 1.26370498493024e-78 -2.02470757063903 5.50090046332077e-71 mirMAP -0.345195446899158 1.85452830789045e-52 NA NA NA hsa-miR-15a-5p CDC14B 0.812445324157528 4.50263417099822e-20 -2.02470757063903 5.50090046332077e-71 miRNAWalker2_validate;MirTarget -0.480167282820845 1.29069382491119e-25 NA NA NA hsa-miR-15b-5p CDC14B 0.788659356634696 1.13678211092534e-11 -2.02470757063903 5.50090046332077e-71 MirTarget -0.203940955426639 1.53934894008816e-08 NA NA NA hsa-miR-16-5p CDC14B 0.46835991343556 1.91125356547776e-06 -2.02470757063903 5.50090046332077e-71 miRNAWalker2_validate;MirTarget -0.156356131608184 0.000296508465921112 NA NA NA hsa-miR-17-3p CDC14B 0.721439431208839 7.95900548819742e-10 -2.02470757063903 5.50090046332077e-71 MirTarget -0.18455964612159 2.57406831575446e-07 NA NA NA hsa-miR-183-5p CDC14B 2.95681814393872 1.09965777344285e-92 -2.02470757063903 5.50090046332077e-71 MirTarget -0.366803609743414 3.52967334708467e-50 NA NA NA hsa-miR-185-5p CDC14B 0.482334746589337 3.68475879959415e-09 -2.02470757063903 5.50090046332077e-71 MirTarget -0.392436849523867 1.89920188628234e-14 NA NA NA hsa-miR-200a-3p CDC14B 2.55218480823434 2.96135446816238e-51 -2.02470757063903 5.50090046332077e-71 mirMAP -0.293218947907091 2.14473413178426e-38 NA NA NA hsa-miR-21-3p CDC14B 2.17476065946878 5.15299442583591e-75 -2.02470757063903 5.50090046332077e-71 mirMAP -0.35217194522348 8.71028295359471e-29 NA NA NA hsa-miR-30d-3p CDC14B 0.264544633563642 0.00755023189129747 -2.02470757063903 5.50090046332077e-71 MirTarget -0.182598416415109 2.24452436311123e-05 NA NA NA hsa-miR-429 CDC14B 2.84108892259147 3.88520896426515e-64 -2.02470757063903 5.50090046332077e-71 PITA;miRanda;miRNATAP -0.31370536352721 5.1329050278184e-45 NA NA NA hsa-miR-590-3p CDC14B 1.27438512890514 1.03164723481469e-23 -2.02470757063903 5.50090046332077e-71 miRanda;mirMAP -0.209129409374126 6.57486825792369e-10 NA NA NA hsa-miR-590-5p CDC14B 0.746515607868274 8.51300479640125e-09 -2.02470757063903 5.50090046332077e-71 miRanda -0.128247317933658 8.25405546320195e-05 NA NA NA hsa-miR-215-5p CDC20 -1.35643065897947 2.3180023440257e-20 3.66853104236588 4.96778311810003e-83 miRNAWalker2_validate -0.145616869632133 0.00256934863409543 NA NA NA hsa-miR-30a-5p CDC20 -0.392489994825279 0.00954894667761676 3.66853104236588 4.96778311810003e-83 miRNAWalker2_validate -0.4198947196033 2.67201477679778e-19 NA NA NA hsa-let-7a-5p CDC25A -0.210286642041636 0.0072546234707717 2.05215023166215 3.612925024162e-38 MirTarget;TargetScan;miRNATAP -0.560702898770607 9.2571247445682e-15 NA NA NA hsa-let-7b-5p CDC25A -0.54215483448257 7.21347617597858e-08 2.05215023166215 3.612925024162e-38 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.486831889501589 1.53889811373871e-18 NA NA NA hsa-let-7c-5p CDC25A -1.9415540533505 9.55250745007793e-48 2.05215023166215 3.612925024162e-38 MirTarget -0.484468578750932 3.12033543980457e-36 25909324 MicroRNA let 7c Inhibits Cell Proliferation and Induces Cell Cycle Arrest by Targeting CDC25A in Human Hepatocellular Carcinoma; The aim of the present study was to determine whether the cell cycle regulator CDC25A is involved in the antitumor effect of let-7c in HCC; The luciferase reporter assay showed that CDC25A was a direct target of let-7c and that let-7c inhibited the expression of CDC25A protein by directly targeting its 3' UTR; In conclusion this study indicates that let-7c suppresses HCC progression possibly by directly targeting the cell cycle regulator CDC25A and indirectly affecting its downstream target molecules progression liver cancer hsa-miR-195-5p CDC25A -1.47508108420708 2.20685847368258e-38 2.05215023166215 3.612925024162e-38 MirTarget;miRNATAP -0.526141164353217 5.88108869367829e-30 NA NA NA hsa-miR-337-3p CDC25A -2.14274617598363 2.70942896809734e-43 2.05215023166215 3.612925024162e-38 mirMAP -0.348639875970048 7.23733595552888e-25 NA NA NA hsa-miR-34c-5p CDC25A -0.0896438810345765 0.557016551646841 2.05215023166215 3.612925024162e-38 miRNATAP -0.305631702899559 1.31456413892807e-16 21321636 Ectopic expression of miR-449b and miR-34c resulted in lowered adhesion activities by 28%-34% and in cell cycle arrests with increased cell number of 15.62% and 15.71% in G1 and with decreased cell number of 15.96% and 16.56% in S Cell cycle related proteins CDK6 and CDC25A were down-regulated; The decreases of CDK6 and CDC25A by miR-449b were 39% and 22% respecyively; 49% and 32% by miR-34c respectively ovarian cancer hsa-miR-497-5p CDC25A -1.4667331575679 5.49909921822638e-36 2.05215023166215 3.612925024162e-38 MirTarget;miRNATAP -0.282142045758064 1.14697299661542e-09 NA NA NA hsa-let-7a-5p CDC25B -0.210286642041636 0.0072546234707717 0.886543805261515 7.65591725785136e-15 miRNAWalker2_validate -0.431940489849114 7.06528609848609e-18 NA NA NA hsa-miR-26b-5p CDC25B -0.331527896896866 0.000551258576575092 0.886543805261515 7.65591725785136e-15 miRNAWalker2_validate -0.109974098209589 0.00808270963890976 NA NA NA hsa-miR-15a-5p CDC27 0.812445324157528 4.50263417099822e-20 -0.175689720386495 0.00426702146693525 miRNATAP -0.130564494261023 1.82490853553183e-08 NA NA NA hsa-miR-361-5p CDC27 -0.0996867547900457 0.095428250126326 -0.175689720386495 0.00426702146693525 miRanda -0.199393823468005 2.1010787835752e-08 NA NA NA hsa-miR-199a-5p CDC6 -0.314703593105081 0.00909304983051124 2.66170471766001 7.30134923477903e-56 miRanda -0.351338361226703 5.62419250907845e-12 NA NA NA hsa-miR-199b-5p CDC6 -1.37022396448377 3.25758057539223e-26 2.66170471766001 7.30134923477903e-56 miRanda -0.486934563173291 4.37221050319896e-27 NA NA NA hsa-miR-26a-5p CDC6 -0.481180084102235 1.82368246174758e-10 2.66170471766001 7.30134923477903e-56 miRNAWalker2_validate -0.675639681820938 6.05217540988535e-17 25100863;27158389 Here it is demonstrated that miR26a and miR26b inhibit replication licensing and the proliferation migration and invasion of lung cancer cells by targeting CDC6; The current study suggests that miR26a miR26b and CDC6 and factors regulating their expression represent potential cancer diagnostic and prognostic markers as well as anticancer targets;miR 26a inhibits the proliferation of ovarian cancer cells via regulating CDC6 expression; Bioinformatics analysis revealed Cdc6 was a target gene of miR-26a; dual-luciferase assay and validation assay showed miR-26a could act on the 3'UTR of Cdc6 to regulate Cdc6 expression; These findings suggest that miR-26a may act on the 3'UTR of Cdc6 to regulate Cdc6 expression which then inhibit the proliferation of ovarian cancer cells and induce their apoptosis ; lung cancer;ovarian cancer hsa-let-7a-5p CDC7 -0.210286642041636 0.0072546234707717 1.63325833885766 1.18170870060963e-37 miRNAWalker2_validate -0.304943904371664 1.86929636223706e-07 NA NA NA hsa-miR-101-3p CDC7 -0.126035286271986 0.145997832808138 1.63325833885766 1.18170870060963e-37 miRNAWalker2_validate -0.224248027206967 2.302830114026e-05 NA NA NA hsa-miR-126-5p CDC7 -1.27745588751177 2.96000918537631e-30 1.63325833885766 1.18170870060963e-37 mirMAP -0.16158215060846 4.1885578436873e-05 NA NA NA hsa-miR-199a-5p CDC7 -0.314703593105081 0.00909304983051124 1.63325833885766 1.18170870060963e-37 MirTarget;miRanda -0.323534962243721 3.44719051316279e-18 NA NA NA hsa-miR-199b-5p CDC7 -1.37022396448377 3.25758057539223e-26 1.63325833885766 1.18170870060963e-37 MirTarget;miRanda -0.376753345312949 5.19004747856031e-30 NA NA NA hsa-miR-335-5p CDC7 -2.61355235628987 2.6462884165886e-51 1.63325833885766 1.18170870060963e-37 MirTarget -0.176434008401993 5.58066636177811e-13 NA NA NA hsa-miR-34c-5p CDC7 -0.0896438810345765 0.557016551646841 1.63325833885766 1.18170870060963e-37 miRanda -0.180192014484994 1.60921917702441e-09 NA NA NA hsa-miR-10b-3p CDK2 -1.58463104907636 1.17335119858099e-46 0.628977809366634 3.17063810755044e-21 mirMAP -0.210836970989172 1.24690584925124e-27 NA NA NA hsa-miR-10b-5p CDK2 -2.10996264627796 7.36811595736367e-72 0.628977809366634 3.17063810755044e-21 miRNAWalker2_validate -0.172779155677722 1.52256449776603e-22 NA NA NA hsa-miR-145-5p CDK4 -2.62703571936687 7.64402900188551e-88 0.597969315491349 4.23701383421285e-22 miRNAWalker2_validate;miRTarBase -0.134364969525933 9.65405723067241e-21 21092188 Furthermore we found that CDK4 was regulated by miR-145 in cell cycle control lung squamous cell cancer hsa-miR-195-5p CDK4 -1.47508108420708 2.20685847368258e-38 0.597969315491349 4.23701383421285e-22 miRNAWalker2_validate;miRTarBase -0.168636406260907 2.79019414251395e-21 NA NA NA hsa-miR-103a-3p CDK6 0.610673390034345 1.63113920514646e-12 -1.03099881099472 9.88361268912926e-12 miRNAWalker2_validate;miRNATAP -0.41897711298053 2.13541829274935e-12 NA NA NA hsa-miR-107 CDK6 0.678998026350662 2.56224148930538e-16 -1.03099881099472 9.88361268912926e-12 miRNAWalker2_validate;miRTarBase;PITA;miRNATAP -0.220761526250824 0.000423296532800194 19407485;22491216;21264532;19688090 Enforced expression of miR-107 in MiaPACA-2 and PANC-1 cells downregulated in vitro growth and this was associated with repression of the putative miR-107 target cyclin-dependent kinase 6 thereby providing a functional basis for the epigenetic inactivation of this miRNA in pancreatic cancer;Levels of known miR-107 targets protein kinase Cε PKCε cyclin-dependent kinase 6 CDK6 and hypoxia-inducible factor 1-β HIF1-β decreased following NP/pre-miR-107 treatment;We have identified miR-107 as a potential regulator of CDK6 expression; A bioinformatics search revealed a putative target site for miR-107 within the CDK6 3' untranslated region; Expression of miR-107 in gastric cancer cell lines was found inversely correlated with CDK6 expression; miR-107 could significantly suppress CDK6 3' UTR luciferase reporter activity and this effect was not detectable when the putative 3' UTR target site was mutated; Consistent with the results of the reporter assay ectopic expression of miR-107 reduced both mRNA and protein expression levels of CDK6 inhibited proliferation induced G1 cell cycle arrest and blocked invasion of the gastric cancer cells; Our results suggest that miR-107 may have a tumor suppressor function by directly targeting CDK6 to inhibit the proliferation and invasion activities of gastric cancer cells;Using miRNA-target prediction analyses and the array data we listed up a set of likely targets of miR-107 and miR-185 for G1 cell cycle arrest and validate a subset of them using real-time RT-PCR and immunoblotting for CDK6 ;;; pancreatic cancer;head and neck cancer;gastric cancer;lung squamous cell cancer hsa-miR-141-3p CDK6 2.99777540204168 1.26370498493024e-78 -1.03099881099472 9.88361268912926e-12 TargetScan;miRNATAP -0.155074529575108 1.68227129058067e-07 NA NA NA hsa-miR-15a-5p CDK6 0.812445324157528 4.50263417099822e-20 -1.03099881099472 9.88361268912926e-12 miRNATAP -0.307441214732404 1.1453244726092e-07 NA NA NA hsa-miR-182-5p CDK6 2.36408084103818 2.60011457600281e-72 -1.03099881099472 9.88361268912926e-12 mirMAP -0.302395516858316 3.47976531991082e-17 NA NA NA hsa-miR-191-5p CDK6 0.831652724468215 1.98847993606895e-12 -1.03099881099472 9.88361268912926e-12 miRNAWalker2_validate;miRTarBase -0.206787526199797 2.32979427977823e-06 NA NA NA hsa-miR-193b-3p CDK6 -0.0550374855074773 0.65382485898551 -1.03099881099472 9.88361268912926e-12 miRNAWalker2_validate -0.155046597813103 0.00030084184892796 NA NA NA hsa-miR-200a-3p CDK6 2.55218480823434 2.96135446816238e-51 -1.03099881099472 9.88361268912926e-12 miRNATAP -0.153245463849065 1.36473748839668e-07 24009066 microRNA 200a is an independent prognostic factor of hepatocellular carcinoma and induces cell cycle arrest by targeting CDK6 liver cancer hsa-miR-200b-3p CDK6 2.11744072703209 1.66710572104191e-43 -1.03099881099472 9.88361268912926e-12 mirMAP -0.174815127052701 6.39294256795547e-08 NA NA NA hsa-miR-200c-3p CDK6 2.07038651806183 6.84613386286599e-51 -1.03099881099472 9.88361268912926e-12 mirMAP -0.180928310145507 3.68922155138771e-07 NA NA NA hsa-miR-21-5p CDK6 2.32007501846389 3.08394781855554e-137 -1.03099881099472 9.88361268912926e-12 miRNAWalker2_validate;mirMAP -0.197449989063307 3.4492907261557e-05 NA NA NA hsa-miR-29c-3p CDK6 -0.0652732378039769 0.563774115756922 -1.03099881099472 9.88361268912926e-12 miRNAWalker2_validate;miRTarBase;miRNATAP -0.390844229843503 1.3743800981758e-17 26396669 Furthermore through qPCR and Western blot assays confirmed that overexpression of miR-29c reduced CDK6 mRNA and protein levels; miR-29c could inhibit the proliferation migration and invasion of bladder cancer cells via regulating CDK6 bladder cancer hsa-miR-30a-5p CDK6 -0.392489994825279 0.00954894667761676 -1.03099881099472 9.88361268912926e-12 mirMAP -0.124807010230796 0.000314782970367504 NA NA NA hsa-miR-338-3p CDK6 0.0799903526884966 0.575137668326679 -1.03099881099472 9.88361268912926e-12 mirMAP -0.191800207428879 1.71408750980913e-07 NA NA NA hsa-miR-425-5p CDK6 0.719898949241718 6.01079610190374e-08 -1.03099881099472 9.88361268912926e-12 mirMAP -0.150921506027425 0.000119900868002377 NA NA NA hsa-miR-429 CDK6 2.84108892259147 3.88520896426515e-64 -1.03099881099472 9.88361268912926e-12 mirMAP;miRNATAP -0.133862145668 3.72317905758963e-06 NA NA NA hsa-miR-664a-3p CDK6 -0.237699857923843 0.0197071390183375 -1.03099881099472 9.88361268912926e-12 mirMAP -0.195343666542438 0.000155666654807136 NA NA NA hsa-miR-92b-3p CDK6 1.30248132773644 9.42428674470985e-25 -1.03099881099472 9.88361268912926e-12 miRNATAP -0.108885215584239 0.00691585930585228 NA NA NA hsa-miR-139-5p CDK7 -3.25846663863766 2.62018989415003e-112 0.624526047543756 8.01865871956203e-25 miRanda -0.129552341625226 3.00181094423454e-25 NA NA NA hsa-miR-361-5p CDK7 -0.0996867547900457 0.095428250126326 0.624526047543756 8.01865871956203e-25 miRanda -0.140116178190874 0.000115044307057892 NA NA NA hsa-let-7d-5p CDKN1A 0.410958462607207 6.07808182756787e-06 -0.254319078213554 0.025069242968496 MirTarget -0.209534907854426 9.05682787226141e-07 NA NA NA hsa-let-7g-5p CDKN1A 0.0200025784917734 0.791635298815256 -0.254319078213554 0.025069242968496 MirTarget -0.234754189393088 5.7315667018148e-06 NA NA NA hsa-miR-101-3p CDKN1A -0.126035286271986 0.145997832808138 -0.254319078213554 0.025069242968496 MirTarget -0.12547684489979 0.00551360058669363 NA NA NA hsa-miR-106a-5p CDKN1A 0.574594373206545 0.000145868284001732 -0.254319078213554 0.025069242968496 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.114530864663224 7.53068059714178e-06 25510666 After prediction with online software we further used dual-luciferase reporter gene assay to ensure that TP53INP1 and CDKN1A might be the direct targets of miR-106a liver cancer hsa-miR-106b-5p CDKN1A 1.22477789913175 2.31787213143326e-32 -0.254319078213554 0.025069242968496 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.198769219405748 3.53449473460544e-08 NA NA NA hsa-miR-146a-5p CDKN1A 0.102405752365098 0.486975378688068 -0.254319078213554 0.025069242968496 miRNAWalker2_validate -0.112996377410099 1.83135810400461e-05 NA NA NA hsa-miR-17-5p CDKN1A 0.599531757298529 1.07318660415906e-05 -0.254319078213554 0.025069242968496 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.157707858341151 2.444032078598e-08 26482648;24989082 The low expressions of miR-17 and miR-92 families can maintain cisplatin resistance through the regulation of CDKN1A and RAD21;According to PicTar and Miranda algorithms which predicted CDKN1A p21 as a putative target of miR-17 a luciferase assay was performed and revealed that miR-17 directly targets the 3'-UTR of p21 mRNA drug resistance; lung squamous cell cancer;sarcoma hsa-miR-182-5p CDKN1A 2.36408084103818 2.60011457600281e-72 -0.254319078213554 0.025069242968496 miRNAWalker2_validate -0.114208671947908 2.29748891177513e-05 NA NA NA hsa-miR-20a-5p CDKN1A 0.44979911120222 0.000602386964327228 -0.254319078213554 0.025069242968496 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.126075559540983 1.99860276007902e-05 26012475 Using the poorly tumorigenic and TGF-β-sensitive FET cell line that expresses low miR-20a levels we first confirmed that miR-20a downmodulated CDKN1A expression both at mRNA and protein level through direct binding to its 3'-UTR; Moreover besides modulating CDKN1A miR-20a blocked TGF-β-induced transactivation of its promoter without affecting the post-receptor activation of Smad3/4 effectors directly; Finally miR-20a abrogated the TGF-β-mediated c-Myc repression a direct inhibitor of the CDKN1A promoter activation most likely by reducing the expression of specific MYC-regulating genes from the Smad/E2F-based core repressor complex colon cancer hsa-miR-28-5p CDKN1A -0.14267073663385 0.0497619246260571 -0.254319078213554 0.025069242968496 miRNAWalker2_validate;miRTarBase;MirTarget;miRanda;miRNATAP -0.294350864895331 4.29596264827348e-08 NA NA NA hsa-miR-423-3p CDKN1A 0.338351552541003 0.000947983901628776 -0.254319078213554 0.025069242968496 miRNAWalker2_validate;miRTarBase -0.105368362155166 0.00567064832994105 NA NA NA hsa-miR-455-3p CDKN1A 0.678392920628872 0.000327758844555877 -0.254319078213554 0.025069242968496 MirTarget -0.119773167671374 4.14708070797368e-09 NA NA NA hsa-miR-505-5p CDKN1A -0.842640534241897 4.43022473091907e-09 -0.254319078213554 0.025069242968496 miRNAWalker2_validate;MirTarget -0.108248027724388 5.69419612511767e-05 NA NA NA hsa-miR-93-5p CDKN1A 1.01788600209314 1.24312921618126e-21 -0.254319078213554 0.025069242968496 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.147676795890733 3.39439379040982e-05 25633810 MicroRNA 93 activates c Met/PI3K/Akt pathway activity in hepatocellular carcinoma by directly inhibiting PTEN and CDKN1A; We confirmed that miR-93 directly bound with the 3' untranslated regions of the tumor-suppressor genes PTEN and CDKN1A respectivelyand inhibited their expression; We concluded that miR-93 stimulated cell proliferation migration and invasion through the oncogenic c-Met/PI3K/Akt pathway and also inhibited apoptosis by directly inhibiting PTEN and CDKN1A expression in human HCC liver cancer hsa-miR-942-5p CDKN1A 0.0274758353801279 0.842368857038259 -0.254319078213554 0.025069242968496 miRNAWalker2_validate -0.114405823345184 5.05622411237802e-05 NA NA NA hsa-miR-96-5p CDKN1A 3.24596558166606 1.92296159041707e-98 -0.254319078213554 0.025069242968496 miRNAWalker2_validate;miRTarBase -0.102209126041297 4.86561723152027e-06 26582573 Upregulation of microRNA 96 and its oncogenic functions by targeting CDKN1A in bladder cancer; Bioinformatics prediction combined with luciferase reporter assay were used to verify whether the cyclin-dependent kinase inhibitor CDKN1A was a potential target gene of miR-96; According to the data of miRTarBase CDKN1A might be a candidate target gene of miR-96; In addition luciferase reporter and Western blot assays respectively demonstrated that miR-96 could bind to the putative seed region in CDKN1A mRNA 3'UTR and significantly reduce the expression level of CDKN1A protein; Moreover we found that the inhibition of miR-96 expression remarkably decreased cell proliferation and promoted cell apoptosis of BC cell lines which was consistent with the findings observed following the introduction of CDKN1A cDNA without 3'UTR restored miR-96; Upregulation of miR-96 may contribute to aggressive malignancy partly through suppressing CDKN1A protein expression in BC cells bladder cancer hsa-miR-98-5p CDKN1A 0.656336869298973 9.03113188590466e-15 -0.254319078213554 0.025069242968496 miRNAWalker2_validate;MirTarget -0.175027497589803 0.000116761897589387 NA NA NA hsa-miR-24-3p CDKN1B -0.120123317289941 0.21432376743243 0.123956597380626 0.178678734172075 miRNAWalker2_validate;miRNATAP -0.129882054588421 7.20288249970178e-05 26044523;26847530 With the bioinformatic method we further identified that p27Kip1 is a direct target of miR-24-3p and its protein level was negatively regulated by miR-24-3p;The biological significance of miR-24 expression in prostate cancer cells was assessed by a series of in vitro bioassays and the effect on proposed targets p27 CDKN1B and p16 CDK2NA was investigated ; breast cancer;prostate cancer hsa-miR-505-3p CDKN1B -0.530462599544864 7.71645736541597e-05 0.123956597380626 0.178678734172075 MirTarget -0.109145829867351 2.9885589878634e-06 NA NA NA hsa-miR-107 CDKN1C 0.678998026350662 2.56224148930538e-16 -2.10696277121193 3.07611963088364e-54 miRanda -0.269063282417449 5.61144663419198e-06 NA NA NA hsa-miR-32-5p CDKN1C 1.38676603945192 2.29428299685976e-34 -2.10696277121193 3.07611963088364e-54 MirTarget;miRNATAP -0.301846710363377 4.47897518631398e-13 NA NA NA hsa-miR-320b CDKN1C 0.412787504747938 0.00113457276903985 -2.10696277121193 3.07611963088364e-54 miRanda;miRNATAP -0.161770248369663 4.03547815709149e-05 NA NA NA hsa-miR-34a-5p CDKN1C 0.129201805242403 0.133261654068224 -2.10696277121193 3.07611963088364e-54 miRNATAP -0.278255101538641 1.67359419187959e-06 NA NA NA hsa-miR-429 CDKN1C 2.84108892259147 3.88520896426515e-64 -2.10696277121193 3.07611963088364e-54 miRNATAP -0.278468633884504 2.29984085584048e-25 NA NA NA hsa-miR-493-5p CDKN1C 1.25321217062116 2.58094342947875e-18 -2.10696277121193 3.07611963088364e-54 miRNATAP -0.168345337756979 8.18639835036014e-07 NA NA NA hsa-miR-590-3p CDKN1C 1.27438512890514 1.03164723481469e-23 -2.10696277121193 3.07611963088364e-54 miRanda -0.363234776678318 1.44662811954727e-20 NA NA NA hsa-miR-92b-3p CDKN1C 1.30248132773644 9.42428674470985e-25 -2.10696277121193 3.07611963088364e-54 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.367993702468557 5.00703264967851e-23 NA NA NA hsa-miR-10b-5p CDKN2A -2.10996264627796 7.36811595736367e-72 2.12039399576679 1.36950972049671e-25 miRNAWalker2_validate;miRTarBase -0.715222702174389 1.70829699904957e-41 NA NA NA hsa-miR-125a-5p CDKN2A -0.635694700253268 3.6703235721638e-11 2.12039399576679 1.36950972049671e-25 miRanda -0.588080813765285 7.0950686216042e-16 NA NA NA hsa-miR-125b-5p CDKN2A -1.94393269763542 2.78180543229264e-58 2.12039399576679 1.36950972049671e-25 miRNAWalker2_validate -0.436831582226038 9.31110596805625e-16 23585871 In this study we further extend our studies by showing that miR-125b represses the protein product of the ink4a/ARF locus p14ARF in two prostate cancer cell lines LNCaP wild type-p53 and 22Rv1 both wild type and mutant p53 as well as in the PC-346C prostate cancer xenograft model that lentivirally overexpressed miR-125b; Conversely treatment of prostate cancer cells with an inhibitor of miR-125b anti-miR-125b resulted in increased expression of p14ARF decreased level of Mdm2 and induction of apoptosis; In addition overexpression of miR-125b in p53-deficient PC3 cells induced down-regulation of p14ARF which leads to increased cell proliferation through a p53-independent manner prostate cancer hsa-miR-365a-3p CDKN2A -1.45032725192851 2.37888098061118e-37 2.12039399576679 1.36950972049671e-25 MirTarget -0.389403479218473 7.60310258658509e-11 NA NA NA hsa-miR-429 CDKN2B 2.84108892259147 3.88520896426515e-64 -0.535762100005625 6.04515808229722e-05 miRanda -0.161930481171186 1.19377952611012e-10 NA NA NA hsa-miR-450b-5p CDKN2B 0.781564228875267 3.90462514315383e-11 -0.535762100005625 6.04515808229722e-05 mirMAP -0.154969260267371 5.41198999368989e-05 NA NA NA hsa-miR-671-5p CDKN2B 1.55248047544015 7.7377784125886e-33 -0.535762100005625 6.04515808229722e-05 PITA -0.154028875207593 8.10893805948914e-06 NA NA NA hsa-miR-98-5p CDKN2B 0.656336869298973 9.03113188590466e-15 -0.535762100005625 6.04515808229722e-05 miRNAWalker2_validate -0.143107086249608 0.00777262486006497 NA NA NA hsa-miR-182-5p CDKN2C 2.36408084103818 2.60011457600281e-72 -1.07930959319688 4.54026994590945e-24 MirTarget -0.276641968146447 8.40974172250093e-28 NA NA NA hsa-miR-139-5p CHEK1 -3.25846663863766 2.62018989415003e-112 1.25798968980226 1.05480144252256e-29 miRanda -0.300486863727614 2.11897109250447e-40 NA NA NA hsa-miR-195-5p CHEK1 -1.47508108420708 2.20685847368258e-38 1.25798968980226 1.05480144252256e-29 MirTarget;miRNATAP -0.385549885297148 9.47498908417406e-34 25840419 MiR 195 suppresses non small cell lung cancer by targeting CHEK1; We discovered that CHEK1 was a direct target of miR-195 which decreased CHEK1 expression in lung cancer cells lung squamous cell cancer hsa-miR-495-3p CHEK1 -1.67685437612894 1.70634429769052e-34 1.25798968980226 1.05480144252256e-29 MirTarget -0.163938153068567 2.61716526324285e-09 NA NA NA hsa-miR-497-5p CHEK1 -1.4667331575679 5.49909921822638e-36 1.25798968980226 1.05480144252256e-29 MirTarget;miRNATAP -0.193287579748198 1.64610972227681e-09 24464213 Checkpoint kinase 1 is negatively regulated by miR 497 in hepatocellular carcinoma; In silico analysis showed that CHEK1 was a candidate target of miR-497 which was previously found to be downregulated in HCC by us; To test whether miR-497 could bind to 3'untranslated region 3'UTR of CHEK1 luciferase reporter assay was conducted; The result revealed that miR-497 could bind to the 3'untranslated region 3'UTR of CHEK1 mRNA; Western blot showed that ectopic expression of miR-497 suppressed the CHEK1 expression and inhibition of miR-497 led to significant upregulation of CHEK1; Finally miR-497 expression was measured in the same 30 HCC samples and the correlation between miR-497 and CHEK1 was analyzed; The results indicated that miR-497 was downregulated in HCC and had a significant negative correlation with CHEK1; Taken together these results demonstrated that CHEK1 was negatively regulated by miR-497 and the overexpressed CHEK1 was resulted from the downregulated miR-497 in HCC which provided a potential molecular target for HCC therapy liver cancer hsa-miR-361-5p CREBBP -0.0996867547900457 0.095428250126326 -0.207546077707359 0.000564449557347142 PITA;miRanda;miRNATAP -0.169327426710038 1.27069129226647e-06 NA NA NA hsa-miR-374a-3p CREBBP 0.34122393953022 2.28714105382856e-05 -0.207546077707359 0.000564449557347142 miRNATAP -0.118175129899399 3.92114134022804e-06 NA NA NA hsa-miR-590-3p CREBBP 1.27438512890514 1.03164723481469e-23 -0.207546077707359 0.000564449557347142 PITA;miRanda;mirMAP;miRNATAP -0.100564166407458 8.68617817381304e-10 NA NA NA hsa-miR-10b-3p DBF4 -1.58463104907636 1.17335119858099e-46 1.09073704108042 1.41312552290761e-34 MirTarget -0.35679667850697 2.09458093456735e-43 NA NA NA hsa-miR-195-3p DBF4 -1.49582726452416 6.53261924105147e-40 1.09073704108042 1.41312552290761e-34 mirMAP -0.2708291657078 2.60048548283317e-25 NA NA NA hsa-miR-199a-5p DBF4 -0.314703593105081 0.00909304983051124 1.09073704108042 1.41312552290761e-34 miRanda -0.22262541711916 7.73087101811605e-18 NA NA NA hsa-miR-199b-5p DBF4 -1.37022396448377 3.25758057539223e-26 1.09073704108042 1.41312552290761e-34 miRanda -0.245307100318964 2.74086498178063e-26 NA NA NA hsa-miR-30a-5p DBF4 -0.392489994825279 0.00954894667761676 1.09073704108042 1.41312552290761e-34 MirTarget -0.196582177698698 7.73574951678058e-22 NA NA NA hsa-miR-411-5p DBF4 -0.975911498088906 3.12547465315205e-11 1.09073704108042 1.41312552290761e-34 MirTarget -0.14022142529153 5.89383394735536e-11 NA NA NA hsa-miR-486-5p DBF4 -3.87258704301474 1.22658629378451e-80 1.09073704108042 1.41312552290761e-34 miRanda -0.1210357957106 1.87581937119865e-18 NA NA NA hsa-let-7a-5p E2F1 -0.210286642041636 0.0072546234707717 2.60062333464716 6.00545189391833e-64 miRNAWalker2_validate -0.563697806472921 7.70706849164702e-15 NA NA NA hsa-miR-10a-5p E2F1 -0.798524155913801 2.99126531473748e-08 2.60062333464716 6.00545189391833e-64 miRNAWalker2_validate -0.398268249389221 2.53512308078993e-25 NA NA NA hsa-miR-126-3p E2F1 -1.17432628002954 1.02041618253013e-20 2.60062333464716 6.00545189391833e-64 miRNAWalker2_validate -0.216469719235728 1.00943261671957e-06 NA NA NA hsa-miR-205-5p E2F1 -1.70057043266505 1.20976599540743e-09 2.60062333464716 6.00545189391833e-64 miRNAWalker2_validate;miRTarBase;miRNATAP -0.154229027607252 9.82898858548395e-15 22578566;21454583 Re-expression of miR-205 where absent strongly reduces cell proliferation cell cycle progression and clonogenic potential in vitro and inhibits tumor growth in vivo and this tumor suppressor activity is at least partially exerted through targeting of E2F1 master regulator of cell cycle progression and LAMC1 component of extracellular matrix involved in cell adhesion proliferation and migration;The expression levels of E2F1 and E2F5 were correlated inversely with that of miR-205 in melanoma cell lines; miR-205 significantly suppressed the luciferase activity of reporter plasmids containing the 3'-UTR sequences complementary to either E2F1 or E2F5; Overexpression of miR-205 in melanoma cells reduced E2F1 and E2F5 protein levels progression; breast cancer;melanoma hsa-miR-223-3p E2F1 -0.966406159689943 7.90612601654887e-12 2.60062333464716 6.00545189391833e-64 miRNAWalker2_validate;miRTarBase -0.143216930870757 0.000341168021306422 20029046 Cell cycle regulator E2F1 and microRNA 223 comprise an autoregulatory negative feedback loop in acute myeloid leukemia; In this report we demonstrate that during granulopoiesis microRNA-223 targets E2F1; E2F1 protein was up-regulated in miR-223 null mice; Our study supports a molecular network involving miR-223 C/EBPalpha and E2F1 as major components of the granulocyte differentiation program which is deregulated in AML differentiation acute myeloid leukemia hsa-let-7a-5p E2F2 -0.210286642041636 0.0072546234707717 2.47908228119369 4.05956501303772e-53 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.54703247926146 3.4814843083203e-13 20418948;25647078 MicroRNA let 7a inhibits proliferation of human prostate cancer cells in vitro and in vivo by targeting E2F2 and CCND2;Tumor suppressive microRNA let 7a inhibits cell proliferation via targeting of E2F2 in osteosarcoma cells; When let-7a was transfected into OS cell lines the expression of E2F2 in the cells was greatly suppressed suggesting that E2F2 is a target of miRNA-let-7a in OS cells ; prostate cancer;sarcoma hsa-let-7b-5p E2F2 -0.54215483448257 7.21347617597858e-08 2.47908228119369 4.05956501303772e-53 MirTarget -0.479905788881043 7.89309674968125e-17 NA NA NA hsa-let-7c-5p E2F2 -1.9415540533505 9.55250745007793e-48 2.47908228119369 4.05956501303772e-53 MirTarget -0.501996763790035 3.6569045561674e-36 NA NA NA hsa-miR-125a-5p E2F2 -0.635694700253268 3.6703235721638e-11 2.47908228119369 4.05956501303772e-53 MirTarget -0.289928733019447 1.96913291620687e-06 NA NA NA hsa-miR-125b-5p E2F2 -1.94393269763542 2.78180543229264e-58 2.47908228119369 4.05956501303772e-53 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.49415542747754 3.98661086706935e-29 22999819 miR 125b regulates the proliferation of glioblastoma stem cells by targeting E2F2; This study demonstrated that miR-125b plays important roles in regulating the proliferation of GSCs by directly targeting E2F2 glioblastoma hsa-miR-214-3p E2F2 -0.523705501275844 0.000211299789901139 2.47908228119369 4.05956501303772e-53 mirMAP -0.205132057875323 9.56651579239763e-07 NA NA NA hsa-miR-214-5p E2F2 0.0510982283488062 0.676107227554816 2.47908228119369 4.05956501303772e-53 MirTarget;miRNATAP -0.159689140997382 0.000999704831392547 NA NA NA hsa-miR-22-3p E2F2 -0.505819481364718 1.90494905330622e-13 2.47908228119369 4.05956501303772e-53 miRNAWalker2_validate -0.357717763951494 2.94595884569596e-05 NA NA NA hsa-miR-26a-5p E2F2 -0.481180084102235 1.82368246174758e-10 2.47908228119369 4.05956501303772e-53 miRNATAP -0.47918433809714 6.84491162494811e-10 26458859 MiR 26a enhances the sensitivity of gastric cancer cells to cisplatin by targeting NRAS and E2F2; Our results suggest that miR-26a can improve the sensitivity of GC cells to cisplatin-based chemotherapies through targeting NRAS and E2F2 and provide the first evidence of the potential utility of miR-26a as a sensitizer in chemotherapy for GC gastric cancer hsa-miR-26b-5p E2F2 -0.331527896896866 0.000551258576575092 2.47908228119369 4.05956501303772e-53 miRNATAP -0.171549355869544 0.00555859612518612 NA NA NA hsa-miR-30c-2-3p E2F2 -0.793306601708467 2.88673428932496e-07 2.47908228119369 4.05956501303772e-53 MirTarget -0.387340206175811 1.007001428665e-25 NA NA NA hsa-miR-320a E2F2 -0.287921276129346 0.00141693637596294 2.47908228119369 4.05956501303772e-53 mirMAP -0.170551020366879 0.00968439534942689 NA NA NA hsa-miR-365a-3p E2F2 -1.45032725192851 2.37888098061118e-37 2.47908228119369 4.05956501303772e-53 MirTarget -0.380061114910508 1.0764063005319e-14 NA NA NA hsa-miR-432-5p E2F2 -1.27705834793565 1.47191322114198e-20 2.47908228119369 4.05956501303772e-53 mirMAP -0.350873256509748 2.92203851023349e-17 NA NA NA hsa-miR-539-5p E2F2 -1.28530285996605 1.62620330363951e-14 2.47908228119369 4.05956501303772e-53 mirMAP -0.122156699223386 0.000463440651429814 NA NA NA hsa-let-7b-5p E2F3 -0.54215483448257 7.21347617597858e-08 0.722298179791941 1.47364190074422e-14 miRNAWalker2_validate -0.197387569108858 7.76434411663351e-10 NA NA NA hsa-miR-101-3p E2F3 -0.126035286271986 0.145997832808138 0.722298179791941 1.47364190074422e-14 miRNAWalker2_validate -0.178116714054424 2.50156627298113e-06 NA NA NA hsa-miR-10a-5p E2F3 -0.798524155913801 2.99126531473748e-08 0.722298179791941 1.47364190074422e-14 miRNATAP -0.234889087314474 5.42573147386169e-27 NA NA NA hsa-miR-10b-5p E2F3 -2.10996264627796 7.36811595736367e-72 0.722298179791941 1.47364190074422e-14 miRNATAP -0.259456478181933 7.43240431726397e-26 NA NA NA hsa-miR-140-3p E2F3 -1.25844395244141 5.29222651039892e-33 0.722298179791941 1.47364190074422e-14 mirMAP -0.105925685177762 0.000400407439045477 NA NA NA hsa-miR-145-5p E2F3 -2.62703571936687 7.64402900188551e-88 0.722298179791941 1.47364190074422e-14 miRNATAP -0.119587655423822 5.65169736724442e-08 25762621 miR 145 mediates the antiproliferative and gene regulatory effects of vitamin D3 by directly targeting E2F3 in gastric cancer cells; Furthermore miR-145 expression was lower in tumors compared with matched normal samples and correlated with increased the E2F3 transcription factor protein staining gastric cancer hsa-miR-195-5p E2F3 -1.47508108420708 2.20685847368258e-38 0.722298179791941 1.47364190074422e-14 miRNAWalker2_validate;miRTarBase;miRNATAP -0.214649808072275 1.92783048642826e-15 22217655 We identified E2F3 and CCND3 as functional downstream targets of miR-195 in glioblastoma cells glioblastoma hsa-miR-199a-5p E2F3 -0.314703593105081 0.00909304983051124 0.722298179791941 1.47364190074422e-14 PITA;miRanda -0.154322274296216 1.0161134804579e-08 NA NA NA hsa-miR-199b-5p E2F3 -1.37022396448377 3.25758057539223e-26 0.722298179791941 1.47364190074422e-14 PITA;miRanda -0.163095586951789 1.78213671243033e-11 NA NA NA hsa-miR-30a-5p E2F3 -0.392489994825279 0.00954894667761676 0.722298179791941 1.47364190074422e-14 miRNATAP -0.128287443989803 2.0620212341928e-09 NA NA NA hsa-miR-320a E2F3 -0.287921276129346 0.00141693637596294 0.722298179791941 1.47364190074422e-14 PITA;miRanda;miRNATAP -0.11805772527375 0.00116784540258172 NA NA NA hsa-miR-34c-5p E2F3 -0.0896438810345765 0.557016551646841 0.722298179791941 1.47364190074422e-14 miRNAWalker2_validate;miRTarBase;PITA;miRanda;miRNATAP -0.154023269167701 4.30473778465556e-13 21351256 In concordance to this miR-34c was found to negatively regulate the oncogenes E2F3 and BCL-2 which stimulates proliferation and suppress apoptosis in PCa cells respectively prostate cancer hsa-let-7a-5p E2F5 -0.210286642041636 0.0072546234707717 1.22057233889235 9.21129944070499e-24 MirTarget;TargetScan;miRNATAP -0.252632998058136 4.16489182218567e-06 NA NA NA hsa-let-7b-5p E2F5 -0.54215483448257 7.21347617597858e-08 1.22057233889235 9.21129944070499e-24 miRNAWalker2_validate;MirTarget;miRNATAP -0.208792220314713 7.49186766676534e-07 NA NA NA hsa-let-7c-5p E2F5 -1.9415540533505 9.55250745007793e-48 1.22057233889235 9.21129944070499e-24 MirTarget -0.287024192767085 1.82102078575949e-22 NA NA NA hsa-miR-1-3p E2F5 -1.92761220689044 2.14541307073875e-29 1.22057233889235 9.21129944070499e-24 MirTarget -0.197646452192756 1.30207517693539e-16 NA NA NA hsa-miR-154-5p E2F5 -1.13112031257162 1.15116720453339e-14 1.22057233889235 9.21129944070499e-24 MirTarget;miRNATAP -0.129030803814152 8.20733931583736e-06 27398145;27074041 MicroRNA 154 inhibits growth and invasion of breast cancer cells through targeting E2F5; Luciferase reporter assay and Western blot was used to verify E2F transcription factor 5 protein E2F5 as a novel target gene of miR-154; E2F5 was identified as a target of miR-154 and its expression was inversely correlated with miR-154 expression in clinical breast cancer tissues; In addition downregulation of E2F5 in MCF7 cells had similar effect on cell proliferation cycle migration and invasion by miR-154 induced; These findings indicate that miR-154 acts as a tumor suppressor by targeting E2F5 suggesting miR-154 as a potential therapeutic target for the treatment of breast cancer;The effects of forced miR-154-5p expression or E2F transcription factor 5 E2F5 knockdown on PCa cells were evaluated by cell proliferation flow cytometry cell migration and invasion assays as well as by Western blot analysis; The forced expression of miR-154-5p or E2F5 knockdown significantly restrained cell growth as well as the migratory and invasive capabilities; Hence E2F5 is a direct target gene of miR-154-5p miR-154-5p may play an important role as an inhibitor of proliferation migration and invasion of PCa by targeting E2F5 in PCa cell lines ;cell migration breast cancer;prostate cancer hsa-miR-199a-5p E2F5 -0.314703593105081 0.00909304983051124 1.22057233889235 9.21129944070499e-24 miRanda -0.303224745258506 3.21231496741469e-18 NA NA NA hsa-miR-199b-5p E2F5 -1.37022396448377 3.25758057539223e-26 1.22057233889235 9.21129944070499e-24 miRanda -0.336927501630045 2.45223402264681e-27 NA NA NA hsa-miR-335-5p E2F5 -2.61355235628987 2.6462884165886e-51 1.22057233889235 9.21129944070499e-24 miRNAWalker2_validate -0.122773312196824 1.03172977893697e-07 NA NA NA hsa-miR-337-3p E2F5 -2.14274617598363 2.70942896809734e-43 1.22057233889235 9.21129944070499e-24 MirTarget;PITA -0.228149350398858 4.79737697762728e-19 NA NA NA hsa-miR-34c-5p E2F5 -0.0896438810345765 0.557016551646841 1.22057233889235 9.21129944070499e-24 MirTarget;PITA;miRanda;miRNATAP -0.132406436564757 2.42305122201497e-06 NA NA NA hsa-miR-378a-3p E2F5 -1.79882978380301 1.05005373951733e-38 1.22057233889235 9.21129944070499e-24 miRNAWalker2_validate -0.188942985347346 1.06561996595534e-10 NA NA NA hsa-miR-495-3p E2F5 -1.67685437612894 1.70634429769052e-34 1.22057233889235 9.21129944070499e-24 MirTarget -0.238991250342934 6.79487454514355e-16 NA NA NA hsa-miR-106b-5p EP300 1.22477789913175 2.31787213143326e-32 -0.378121576001413 5.1159454625656e-06 miRNATAP -0.191649543350323 2.95239597393248e-13 NA NA NA hsa-miR-181b-5p EP300 1.22749257795094 1.21998198830919e-27 -0.378121576001413 5.1159454625656e-06 miRNAWalker2_validate -0.187884049605316 7.93444158362854e-15 NA NA NA hsa-miR-20a-5p EP300 0.44979911120222 0.000602386964327228 -0.378121576001413 5.1159454625656e-06 miRNATAP -0.151748232339608 1.59846335234487e-12 NA NA NA hsa-miR-25-3p EP300 -0.00546790775985073 0.944061771389468 -0.378121576001413 5.1159454625656e-06 miRNAWalker2_validate -0.101950779775411 0.00585001386907759 NA NA NA hsa-miR-361-3p EP300 -0.0370446538644886 0.624902392829872 -0.378121576001413 5.1159454625656e-06 PITA -0.139187579360879 0.000249736724501524 NA NA NA hsa-let-7a-5p ESPL1 -0.210286642041636 0.0072546234707717 3.03346495975631 2.14527071072931e-74 MirTarget;TargetScan -0.516345282991116 9.52430775163031e-11 NA NA NA hsa-let-7b-5p ESPL1 -0.54215483448257 7.21347617597858e-08 3.03346495975631 2.14527071072931e-74 MirTarget -0.545244581997739 2.57948421000592e-19 NA NA NA hsa-let-7c-5p ESPL1 -1.9415540533505 9.55250745007793e-48 3.03346495975631 2.14527071072931e-74 MirTarget -0.607641593572976 2.48946984432808e-48 NA NA NA hsa-miR-10a-5p ESPL1 -0.798524155913801 2.99126531473748e-08 3.03346495975631 2.14527071072931e-74 miRNAWalker2_validate -0.380703234839265 1.92747042860645e-19 NA NA NA hsa-miR-125a-5p ESPL1 -0.635694700253268 3.6703235721638e-11 3.03346495975631 2.14527071072931e-74 miRanda -0.246004955829991 0.000139678457783333 NA NA NA hsa-miR-127-3p ESPL1 -1.02337931491694 2.9749745518131e-15 3.03346495975631 2.14527071072931e-74 miRanda -0.40291441108457 5.37074061957648e-18 NA NA NA hsa-miR-10b-5p FZR1 -2.10996264627796 7.36811595736367e-72 0.573165619167388 5.17199488609469e-18 mirMAP -0.151118311330591 1.15407415870322e-17 NA NA NA hsa-miR-125a-5p FZR1 -0.635694700253268 3.6703235721638e-11 0.573165619167388 5.17199488609469e-18 mirMAP -0.139723986468696 3.97830208850942e-09 NA NA NA hsa-miR-125b-2-3p FZR1 -1.92374904783012 2.30779527653582e-38 0.573165619167388 5.17199488609469e-18 mirMAP -0.100468304103842 8.2444270660702e-12 NA NA NA hsa-miR-125b-5p FZR1 -1.94393269763542 2.78180543229264e-58 0.573165619167388 5.17199488609469e-18 mirMAP -0.165909692476356 1.64701965663165e-21 NA NA NA hsa-miR-1271-5p FZR1 -1.08290983583835 3.85149976357318e-12 0.573165619167388 5.17199488609469e-18 mirMAP -0.1396292138893 3.75983603459942e-22 NA NA NA hsa-miR-181a-2-3p FZR1 -0.0718643470098321 0.422077954889554 0.573165619167388 5.17199488609469e-18 mirMAP -0.11664639024663 6.94918905051367e-06 NA NA NA hsa-miR-326 FZR1 -1.54449030848141 1.04703417845594e-17 0.573165619167388 5.17199488609469e-18 mirMAP -0.109112058523101 9.21906685900211e-19 NA NA NA hsa-miR-484 FZR1 0.349444060004737 0.00154491249625173 0.573165619167388 5.17199488609469e-18 mirMAP -0.104019803698735 6.42737019126444e-07 NA NA NA hsa-miR-491-5p FZR1 -1.04307210952796 1.14586501470398e-15 0.573165619167388 5.17199488609469e-18 MirTarget -0.14018351170178 5.7669226741061e-16 NA NA NA hsa-miR-532-3p FZR1 -0.395473145042459 0.00686714288452761 0.573165619167388 5.17199488609469e-18 mirMAP -0.107014926688685 7.71424221082273e-12 NA NA NA hsa-miR-148b-3p GADD45A 1.0552576751879 1.6679285705231e-29 -0.208892067351644 0.0348101740051854 MirTarget -0.231496451348305 2.77073546077852e-11 NA NA NA hsa-miR-331-5p GADD45A 0.682437632502949 4.10871642662371e-11 -0.208892067351644 0.0348101740051854 PITA;miRNATAP -0.123517623290777 0.000150251086827537 NA NA NA hsa-miR-1976 GADD45B 0.289190368864725 0.00167092758216584 0.00189543029343842 0.986264142476403 miRNATAP -0.184077522593828 6.9983734252811e-06 NA NA NA hsa-miR-324-3p GADD45B 0.404877731996915 0.000340036423920834 0.00189543029343842 0.986264142476403 MirTarget;miRNATAP -0.272759607730261 8.22009676059255e-17 NA NA NA hsa-miR-590-3p GADD45B 1.27438512890514 1.03164723481469e-23 0.00189543029343842 0.986264142476403 miRanda -0.144434950089762 1.57603896644092e-06 NA NA NA hsa-miR-1468-5p GADD45G -1.39112473580933 7.93337422009489e-22 1.62405350947909 6.25407490128674e-20 MirTarget -0.329853422258391 1.46530042095361e-15 NA NA NA hsa-miR-1976 GADD45G 0.289190368864725 0.00167092758216584 1.62405350947909 6.25407490128674e-20 MirTarget -0.31549221771233 3.22063864824767e-06 NA NA NA hsa-miR-101-3p GSK3B -0.126035286271986 0.145997832808138 0.16507499183074 0.0104993269942212 miRNATAP -0.1804025732635 1.07790099640944e-12 NA NA NA hsa-miR-181a-5p GSK3B 0.635863607630183 6.72486918157744e-11 0.16507499183074 0.0104993269942212 mirMAP -0.116539047078398 1.93667948800215e-07 NA NA NA hsa-miR-26a-5p GSK3B -0.481180084102235 1.82368246174758e-10 0.16507499183074 0.0104993269942212 miRNAWalker2_validate;miRNATAP -0.275908606747704 3.58443650423207e-22 NA NA NA hsa-miR-29a-3p GSK3B -0.699539666833076 1.13935003139957e-13 0.16507499183074 0.0104993269942212 miRNATAP -0.20395154397803 2.73691130456682e-19 NA NA NA hsa-miR-29c-3p GSK3B -0.0652732378039769 0.563774115756922 0.16507499183074 0.0104993269942212 miRNATAP -0.148921210430456 1.24088422020447e-14 NA NA NA hsa-miR-320a GSK3B -0.287921276129346 0.00141693637596294 0.16507499183074 0.0104993269942212 miRanda;mirMAP -0.129942826481556 1.0429094971177e-07 NA NA NA hsa-miR-340-5p GSK3B 1.0857159627596 4.94471062546756e-24 0.16507499183074 0.0104993269942212 mirMAP -0.119708017508741 1.77864671732598e-09 NA NA NA hsa-miR-374a-5p GSK3B -0.239709888246804 0.00309819667153627 0.16507499183074 0.0104993269942212 mirMAP -0.161835653986741 2.7137832607523e-09 NA NA NA hsa-miR-542-3p GSK3B 0.568822103820889 8.5699075257651e-07 0.16507499183074 0.0104993269942212 miRanda -0.110477181605807 5.02640445089489e-09 NA NA NA hsa-miR-195-3p HDAC2 -1.49582726452416 6.53261924105147e-40 0.406007405618481 6.82660501815535e-08 mirMAP -0.173918074241148 6.66944715925179e-16 NA NA NA hsa-miR-30a-5p HDAC2 -0.392489994825279 0.00954894667761676 0.406007405618481 6.82660501815535e-08 mirMAP -0.109855705865075 9.27085527279269e-11 NA NA NA hsa-miR-139-5p MAD2L1 -3.25846663863766 2.62018989415003e-112 2.01579534776676 1.28950915382794e-54 miRanda -0.409478418276739 7.02082628030535e-53 NA NA NA hsa-miR-139-5p MCM2 -3.25846663863766 2.62018989415003e-112 1.73269377201954 5.84458756938441e-53 miRanda -0.379699354760018 7.55666672084272e-61 NA NA NA hsa-miR-34c-5p MCM2 -0.0896438810345765 0.557016551646841 1.73269377201954 5.84458756938441e-53 miRanda -0.193659263867364 6.54009934587265e-13 NA NA NA hsa-miR-491-5p MCM2 -1.04307210952796 1.14586501470398e-15 1.73269377201954 5.84458756938441e-53 miRanda -0.17039057031247 5.34823358349639e-08 NA NA NA hsa-let-7b-5p MCM4 -0.54215483448257 7.21347617597858e-08 1.45760657687267 7.97875515771763e-35 miRNAWalker2_validate -0.184107751593985 1.06148134256445e-05 NA NA NA hsa-miR-320a MCM4 -0.287921276129346 0.00141693637596294 1.45760657687267 7.97875515771763e-35 miRNAWalker2_validate -0.179219731091916 0.000139309996646993 NA NA NA hsa-miR-486-5p MCM4 -3.87258704301474 1.22658629378451e-80 1.45760657687267 7.97875515771763e-35 miRanda -0.152023951412333 1.71953741553817e-16 NA NA NA hsa-miR-30c-2-3p MCM6 -0.793306601708467 2.88673428932496e-07 0.827264842324325 2.79366220561717e-22 MirTarget -0.183655931355585 1.30310548073393e-22 NA NA NA hsa-let-7b-5p MCM7 -0.54215483448257 7.21347617597858e-08 0.68267767406409 5.54088787186384e-14 miRNAWalker2_validate -0.24631747761265 1.17772037587033e-15 NA NA NA hsa-miR-143-3p MDM2 -1.23248181631499 4.74160976678504e-28 0.134052426741699 0.110706751806459 miRNAWalker2_validate -0.116551192492011 2.45785814867103e-06 NA NA NA hsa-miR-181a-2-3p MDM2 -0.0718643470098321 0.422077954889554 0.134052426741699 0.110706751806459 mirMAP -0.12266836491989 0.000146166192040392 NA NA NA hsa-miR-25-3p MDM2 -0.00546790775985073 0.944061771389468 0.134052426741699 0.110706751806459 miRNAWalker2_validate;miRTarBase -0.121996633743668 0.00105879152857406 NA NA NA hsa-miR-340-5p MDM2 1.0857159627596 4.94471062546756e-24 0.134052426741699 0.110706751806459 mirMAP -0.114356673254404 1.13062337969042e-05 26718483 MicroRNA 340 inhibits prostate cancer cell proliferation and metastasis by targeting the MDM2 p53 pathway; Our findings suggest that miR-340 may function as a novel tumor suppressor in PCa through the MDM2-p53 pathway by directly targeting MDM2 which may be a promising miRNA-targeted therapy for PCa metastasis prostate cancer hsa-miR-369-3p MDM2 0.0880848299432269 0.48519534195924 0.134052426741699 0.110706751806459 mirMAP -0.139668513237869 8.70962517671477e-10 NA NA NA hsa-miR-374a-5p MDM2 -0.239709888246804 0.00309819667153627 0.134052426741699 0.110706751806459 mirMAP -0.181528999029164 3.25892646409229e-07 NA NA NA hsa-miR-374b-5p MDM2 -0.466781429946153 1.17238311619116e-08 0.134052426741699 0.110706751806459 mirMAP -0.113653249109849 0.00120350297983546 NA NA NA hsa-miR-485-3p MDM2 -0.866822427729628 4.5194665263492e-11 0.134052426741699 0.110706751806459 mirMAP -0.105743116773406 1.17706611197258e-06 NA NA NA hsa-miR-500a-5p MDM2 0.209805801129289 0.119177819862398 0.134052426741699 0.110706751806459 mirMAP -0.119455592892776 2.98058844851876e-08 NA NA NA hsa-miR-584-5p MDM2 -1.75458362433615 2.80754771470968e-33 0.134052426741699 0.110706751806459 mirMAP -0.102042062933 5.80205890285492e-08 NA NA NA hsa-miR-21-5p MYC 2.32007501846389 3.08394781855554e-137 -1.13124656428776 3.22608205108151e-16 miRNAWalker2_validate -0.270190862069706 5.76701615920235e-10 22072622 In contrast the levels of β-catenin TCF/LEF activity and the expression of c-Myc Cyclin-D which are increased in CSCs are also augmented in miR-21 overexpressing colon cancer cells accompanied by an increased sphere forming ability in vitro and tumor formation in SCID mice colon cancer hsa-miR-34a-5p MYC 0.129201805242403 0.133261654068224 -1.13124656428776 3.22608205108151e-16 miRNAWalker2_validate;miRTarBase -0.216308870548993 0.000129276161670072 25572695;25686834;21460242;22159222;23640973;22830357;22235332 The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;miR 34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c Myc pathway;Myc mediated repression of microRNA 34a promotes high grade transformation of B cell lymphoma by dysregulation of FoxP1;MicroRNA 34a suppresses malignant transformation by targeting c Myc transcriptional complexes in human renal cell carcinoma; We investigated the functional effects of microRNA-34a miR-34a on c-Myc transcriptional complexes in renal cell carcinoma; miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region which was revealed by luciferase reporter assays; Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription indicating a novel role of miR-34a in the regulation of transcription by c-Myc;Among them miR-34a was also associated with poor prognosis in 2 independent series of leukemic and nodal MCL and in cooperation with high expression of the MYC oncogene;We report that miR-34a did not inhibit cell proliferation notwithstanding a marked down-regulation of c-MYC;MicroRNA 34a modulates c Myc transcriptional complexes to suppress malignancy in human prostate cancer cells; We studied the functional effects of miR-34a on c-Myc transcriptional complexes in PC-3 prostate cancer cells; miR-34a downregulated expression of c-Myc oncogene by targeting its 3' UTR as shown by luciferase reporter assays; This is the first report to document that miR-34a suppresses assembly and function of the c-Myc-Skp2-Miz1 complex that activates RhoA and the c-Myc-pTEFB complex that elongates transcription of various genes suggesting a novel role of miR-34a in the regulation of transcription by c-Myc complex ;;;malignant trasformation;worse prognosis;; bladder cancer;liver cancer;B cell lymphoma;kidney renal cell cancer;lymphoma;lymphoma;prostate cancer hsa-miR-429 MYC 2.84108892259147 3.88520896426515e-64 -1.13124656428776 3.22608205108151e-16 miRNAWalker2_validate -0.108453248703558 4.76591679996824e-05 21684154;24633485 miR 429 modulates the expression of c myc in human gastric carcinoma cells; SGC-7901 gastric cancer cells were transfected with miR-429 mimics and endogenous c-myc expression was detected by western blots; We performed functional assays using the 3'UTR of the c-myc gene as a miR-429 target in a luciferase reporter assay system; miR-429 significantly downregulated endogenous c-myc expression in SGC-7901 cells; Action of miR/429 on c-myc 3'UTR was confirmed; c-myc is an important miR-429 target gene;It is known that miR-429 is down-regulated and functions as a tumor suppressor by targeting c-myc and PLGG1 in gastric and breast cancer ; gastric cancer;sarcoma hsa-miR-154-5p PCNA -1.13112031257162 1.15116720453339e-14 1.3013234294152 1.00251964670336e-52 miRNATAP -0.125688158547628 1.99835592476787e-09 NA NA NA hsa-miR-217 PCNA -0.616728851115349 8.64977119332241e-05 1.3013234294152 1.00251964670336e-52 miRanda;miRNATAP -0.112109007947833 1.14431999795234e-08 25653720 In vitro treatment with miR-217 mimics significantly suppressed the proliferation of MCF-7 cells induced G1 phase arrest and inhibited the expression of cyclin D1; while these effects were significantly reversed by the restoration of DACH1; In MDA-MB-231 cells treatment with miR-217 inhibitors enhanced the cellular proliferation promoted cell cycle progression and upregulated the expression of cyclin D1 which were neutralized by the pre-treatment of siRNA-DACH1; In vivo inhibition of miR-217 significantly suppressed the xenografts growth and downregulated the expression of cyclin D1 progression breast cancer hsa-miR-30a-5p PCNA -0.392489994825279 0.00954894667761676 1.3013234294152 1.00251964670336e-52 miRNAWalker2_validate -0.147433092741305 3.77961596545367e-13 NA NA NA hsa-let-7b-5p PLK1 -0.54215483448257 7.21347617597858e-08 3.61536656799676 6.1989940433249e-93 miRNAWalker2_validate -0.669049691591639 2.06563024129559e-24 NA NA NA hsa-miR-100-5p PLK1 -1.89453309391092 5.00588682382388e-51 3.61536656799676 6.1989940433249e-93 miRNAWalker2_validate;miRTarBase -0.65902378363173 1.57517800279745e-42 25537513;23151088;22246341;23842624;22120675;21636267 Here we show that miR-100 inhibits maintenance and expansion of BrCSCs in basal-like cancer through Polo-like kinase1 Plk1 down-regulation;MicroRNA 100 is a potential molecular marker of non small cell lung cancer and functions as a tumor suppressor by targeting polo like kinase 1; By using microRNA miR target prediction algorithms we identified miR-100 that might potentially bind the 3'-untranslated region of PLK1 transcripts; The purpose of this study was to investigate the roles of miR-100 and its association with PLK1 in NSCLC development; Finally the effects of miR-100 expression on growth apoptosis and cell cycle of NSCLC cells by posttranscriptionally regulating PLK1 expression were determined; Meanwhile miR-100 mimics could significantly inhibit PLK1 mRNA and protein expression and reduce the luciferase activity of a PLK1 3' untranslated region-based reporter construct in A549 cells; Furthermore small interfering RNA siRNA-mediated PLK1 downregulation could mimic the effects of miR-100 mimics while PLK1 overexpression could partially rescue the phenotypical changes of NSCLC cells induced by miR-100 mimics; Our findings indicate that low miR-100 may be a poor prognostic factor for NSCLC patients and functions as a tumor suppressor by posttranscriptionally regulating PLK1 expression;Together these results suggest that low miR-100 expression may be an independent poor prognostic factor and miR-100 can function as a tumor suppressor by targeting PLK1 in human EOCs;In HCC tissues miR-100 expression was inversely correlated with the expression of plk1 protein r = -0.418; P = 0.029; Therefore downregulation of miR-100 was correlated with progressive pathological feature and poor prognosis in HCC patients and miR-100 could function as a tumor suppressor by targeting plk1;MiR 100 resensitizes docetaxel resistant human lung adenocarcinoma cells SPC A1 to docetaxel by targeting Plk1; Knock-down of Plk1 which was a direct target of miR-100 yielded similar effects as that of ectopic miR-100 expression; The inverse correlation between miR-100 and Plk1 expression was also detected in nude mice SPC-A1/DTX tumor xenografts and clinical lung adenocarcinoma tissues and was proved to be related with the in vivo response to docetaxel; Thus our results suggested that down-regulation of miR-100 could lead to Plk1 over-expression and eventually to docetaxel chemoresistance of human lung adenocarcinoma;Reduced miR 100 expression in cervical cancer and precursors and its carcinogenic effect through targeting PLK1 protein; Through modulating miR-100 expression using miR-100 inhibitor or mimic in vitro cell growth cycle and apoptosis were tested separately by MTT or flow cytometry and meanwhile Polo-like kinase1 PLK1 mRNA and protein expressions were detected by qRT-PCR and immunoblotting; The expression of PLK1 in 125 cervical tissues was also examined by immunohistochemical staining and the correlation between miR-100 and PLK1 expression in the same tissues was analysed; The modulation of miR-100 expression remarkably influenced cell proliferation cycle and apoptosis as well as the level of PLK1 protein but not mRNA in vitro experiments; PLK1 expression was negatively correlated with miR-100 expression in CIN3 and cervical cancer tissues; The reduced miR-100 expression participates in the development of cervical cancer at least partly through loss of inhibition to target gene PLK1 which probably occurs in a relative late phase of carcinogenesis ;;;progression;worse prognosis;drug resistance;tumorigenesis breast cancer;lung squamous cell cancer;ovarian cancer;liver cancer;lung cancer;cervical and endocervical cancer hsa-miR-486-5p PLK1 -3.87258704301474 1.22658629378451e-80 3.61536656799676 6.1989940433249e-93 miRanda -0.334945892330245 1.38948539792593e-30 NA NA NA hsa-miR-320a PRKDC -0.287921276129346 0.00141693637596294 0.426493449220291 1.58591265844974e-05 miRanda -0.125085337919148 0.000935640695278176 NA NA NA hsa-let-7b-5p PTTG1 -0.54215483448257 7.21347617597858e-08 3.23972048977312 4.77224328289371e-86 miRNAWalker2_validate -0.646355788959746 1.10777292734127e-26 NA NA NA hsa-miR-26a-5p PTTG1 -0.481180084102235 1.82368246174758e-10 3.23972048977312 4.77224328289371e-86 miRNAWalker2_validate -0.482804950919481 5.26322068053633e-09 NA NA NA hsa-miR-139-5p RAD21 -3.25846663863766 2.62018989415003e-112 0.640163471263341 1.00173451347388e-10 miRanda -0.181519146531913 2.19972816533815e-19 NA NA NA hsa-miR-195-3p RAD21 -1.49582726452416 6.53261924105147e-40 0.640163471263341 1.00173451347388e-10 MirTarget;miRNATAP -0.182557977992989 1.90491711086736e-10 NA NA NA hsa-miR-199a-5p RAD21 -0.314703593105081 0.00909304983051124 0.640163471263341 1.00173451347388e-10 miRanda -0.228011317389576 3.6398992308108e-16 NA NA NA hsa-miR-199b-5p RAD21 -1.37022396448377 3.25758057539223e-26 0.640163471263341 1.00173451347388e-10 miRanda -0.25402686747612 3.15251308696117e-24 NA NA NA hsa-miR-361-5p RAD21 -0.0996867547900457 0.095428250126326 0.640163471263341 1.00173451347388e-10 PITA;miRanda;miRNATAP -0.163829658452197 0.00500492584835125 NA NA NA hsa-miR-106b-5p RB1 1.22477789913175 2.31787213143326e-32 -0.4298757717294 2.2641632984077e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.336912161002504 3.41690569454934e-33 NA NA NA hsa-miR-130b-3p RB1 1.38122163823846 1.00932179737836e-26 -0.4298757717294 2.2641632984077e-06 miRNAWalker2_validate -0.156904013171831 2.01541166272299e-11 NA NA NA hsa-miR-146b-5p RB1 0.631041661167954 6.20366593452965e-08 -0.4298757717294 2.2641632984077e-06 miRanda -0.177025263248084 2.12386610726219e-11 NA NA NA hsa-miR-17-5p RB1 0.599531757298529 1.07318660415906e-05 -0.4298757717294 2.2641632984077e-06 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.195913380047555 2.66519809201542e-18 NA NA NA hsa-miR-20a-5p RB1 0.44979911120222 0.000602386964327228 -0.4298757717294 2.2641632984077e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.267389118731753 2.81885984685324e-31 NA NA NA hsa-miR-21-5p RB1 2.32007501846389 3.08394781855554e-137 -0.4298757717294 2.2641632984077e-06 miRNAWalker2_validate -0.178426586251413 2.52614483801181e-10 NA NA NA hsa-miR-361-5p RB1 -0.0996867547900457 0.095428250126326 -0.4298757717294 2.2641632984077e-06 miRanda -0.36905676433 2.38396475865241e-12 NA NA NA hsa-miR-374a-3p RB1 0.34122393953022 2.28714105382856e-05 -0.4298757717294 2.2641632984077e-06 mirMAP -0.182608977038803 2.59297431382831e-06 NA NA NA hsa-miR-590-3p RB1 1.27438512890514 1.03164723481469e-23 -0.4298757717294 2.2641632984077e-06 PITA;miRanda -0.124607558452563 6.10684045457144e-07 NA NA NA hsa-miR-590-5p RB1 0.746515607868274 8.51300479640125e-09 -0.4298757717294 2.2641632984077e-06 miRanda -0.131404544808712 3.52677735032944e-08 NA NA NA hsa-miR-93-5p RB1 1.01788600209314 1.24312921618126e-21 -0.4298757717294 2.2641632984077e-06 miRNAWalker2_validate;MirTarget;miRNATAP -0.342947523121894 1.33394315667396e-35 NA NA NA hsa-miR-195-3p RBL1 -1.49582726452416 6.53261924105147e-40 0.258171772260236 0.0557349984337416 MirTarget;mirMAP -0.136404640726563 0.000466660213562153 NA NA NA hsa-miR-199a-5p RBL1 -0.314703593105081 0.00909304983051124 0.258171772260236 0.0557349984337416 miRanda -0.16646935754867 1.35556669022578e-05 NA NA NA hsa-miR-199b-5p RBL1 -1.37022396448377 3.25758057539223e-26 0.258171772260236 0.0557349984337416 miRanda -0.19173327799932 2.62627664412876e-08 NA NA NA hsa-miR-106b-5p RBL2 1.22477789913175 2.31787213143326e-32 -0.777587758921412 2.2971094499013e-22 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.263898121665047 3.64871109439286e-25 NA NA NA hsa-miR-107 RBL2 0.678998026350662 2.56224148930538e-16 -0.777587758921412 2.2971094499013e-22 miRanda -0.214816939727489 9.7538516274009e-11 NA NA NA hsa-miR-17-5p RBL2 0.599531757298529 1.07318660415906e-05 -0.777587758921412 2.2971094499013e-22 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.11529529846799 1.64112965057067e-08 NA NA NA hsa-miR-20a-5p RBL2 0.44979911120222 0.000602386964327228 -0.777587758921412 2.2971094499013e-22 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.182553356518434 3.46682203211793e-18 NA NA NA hsa-miR-429 RBL2 2.84108892259147 3.88520896426515e-64 -0.777587758921412 2.2971094499013e-22 miRanda -0.114178875200587 9.05972696116893e-14 NA NA NA hsa-miR-93-5p RBL2 1.01788600209314 1.24312921618126e-21 -0.777587758921412 2.2971094499013e-22 MirTarget;miRNATAP -0.257781038097889 8.64400419240358e-25 NA NA NA hsa-miR-139-5p RBX1 -3.25846663863766 2.62018989415003e-112 0.647024426818053 3.59244462846658e-20 miRanda -0.138659130309957 7.99349725093936e-22 NA NA NA hsa-miR-130a-3p SKP1 -1.15024914519431 6.51290317952496e-19 0.0738382124630679 0.231791018805648 MirTarget -0.139641825685064 4.17514374271046e-19 NA NA NA hsa-miR-130b-3p SKP1 1.38122163823846 1.00932179737836e-26 0.0738382124630679 0.231791018805648 MirTarget -0.106102178127117 1.72601795720608e-11 NA NA NA hsa-miR-222-3p SKP1 -0.429279381480379 0.00103945569781115 0.0738382124630679 0.231791018805648 MirTarget -0.10501825880122 4.51166430229641e-11 NA NA NA hsa-miR-26a-5p SKP2 -0.481180084102235 1.82368246174758e-10 0.0216858415190058 0.846333537569554 MirTarget -0.324934689951421 9.38965675038351e-11 NA NA NA hsa-miR-30a-5p SKP2 -0.392489994825279 0.00954894667761676 0.0216858415190058 0.846333537569554 MirTarget;miRNATAP -0.199786446801752 9.28718102697433e-16 NA NA NA hsa-miR-181a-5p SMAD2 0.635863607630183 6.72486918157744e-11 -0.328226721195286 1.10147955577876e-10 mirMAP -0.115122429788219 8.47012412856965e-11 24394555 Here we show that miR-181a promotes TGF-β-mediated epithelial-to-mesenchymal transition via repression of its functional target Smad7 miR-181a and phosphorylated Smad2 are enriched in recurrent compared with matched-primary ovarian tumours and their expression is associated with shorter time to recurrence and poor outcome in patients with EOC recurrence ovarian cancer hsa-miR-181b-5p SMAD2 1.22749257795094 1.21998198830919e-27 -0.328226721195286 1.10147955577876e-10 mirMAP -0.112879931507918 3.62142519922135e-14 NA NA NA hsa-miR-340-5p SMAD2 1.0857159627596 4.94471062546756e-24 -0.328226721195286 1.10147955577876e-10 MirTarget -0.145840275032375 8.51041709723394e-21 NA NA NA hsa-miR-361-3p SMAD2 -0.0370446538644886 0.624902392829872 -0.328226721195286 1.10147955577876e-10 miRNATAP -0.128521633108847 3.38235989722682e-08 22675530 Functional analyses showed that Smad2 and TGFß1 are not dysregulated by miR-361-3p and miR-625* in the lung cell line A549 respectively lung cancer hsa-miR-361-5p SMAD2 -0.0996867547900457 0.095428250126326 -0.328226721195286 1.10147955577876e-10 MirTarget -0.168440579811925 1.40285064429544e-08 NA NA NA hsa-miR-542-3p SMAD2 0.568822103820889 8.5699075257651e-07 -0.328226721195286 1.10147955577876e-10 PITA -0.104251622984305 3.31535587210055e-12 NA NA NA hsa-miR-155-5p SMAD3 1.09766314984151 4.55650930885814e-15 -0.590930154862025 2.18041656438712e-13 miRNAWalker2_validate -0.161248941325708 6.88088611744894e-17 27626488 Here we demonstrated that TGF-β1 elevated the expression of miR-155 in colorectal cancer cells through SMAD3 and SMAD4 colorectal cancer hsa-miR-15a-5p SMAD3 0.812445324157528 4.50263417099822e-20 -0.590930154862025 2.18041656438712e-13 MirTarget -0.127238885845652 3.99211956272264e-05 NA NA NA hsa-miR-15b-5p SMAD3 0.788659356634696 1.13678211092534e-11 -0.590930154862025 2.18041656438712e-13 MirTarget -0.103829420518863 1.25324379645245e-05 NA NA NA hsa-miR-17-5p SMAD3 0.599531757298529 1.07318660415906e-05 -0.590930154862025 2.18041656438712e-13 miRNAWalker2_validate -0.144062907194855 1.0396353881575e-12 NA NA NA hsa-miR-185-5p SMAD3 0.482334746589337 3.68475879959415e-09 -0.590930154862025 2.18041656438712e-13 MirTarget -0.139641114876277 4.17733017511663e-05 NA NA NA hsa-miR-18a-5p SMAD3 0.969066793715868 1.69069796425892e-08 -0.590930154862025 2.18041656438712e-13 miRNAWalker2_validate -0.145191271950291 4.28063578565896e-20 23249750 The unexpected effects of miR-18a on CTGF transcription are mediated in part by direct targeting of Smad3 and ensuing weakening of TGFβ signaling glioblastoma hsa-miR-1976 SMAD3 0.289190368864725 0.00167092758216584 -0.590930154862025 2.18041656438712e-13 MirTarget -0.121630671332983 6.52049342337766e-05 NA NA NA hsa-miR-28-5p SMAD3 -0.14267073663385 0.0497619246260571 -0.590930154862025 2.18041656438712e-13 miRNATAP -0.120097254990824 0.00200641803458376 NA NA NA hsa-miR-330-5p SMAD3 0.626063225953928 3.42215028606779e-09 -0.590930154862025 2.18041656438712e-13 miRanda -0.106180722787539 5.07248451793749e-05 NA NA NA hsa-miR-429 SMAD3 2.84108892259147 3.88520896426515e-64 -0.590930154862025 2.18041656438712e-13 miRNATAP -0.102063359852527 2.55000912428033e-11 NA NA NA hsa-miR-590-3p SMAD3 1.27438512890514 1.03164723481469e-23 -0.590930154862025 2.18041656438712e-13 miRanda -0.163099760014662 1.73477690677951e-13 NA NA NA hsa-miR-671-5p SMAD3 1.55248047544015 7.7377784125886e-33 -0.590930154862025 2.18041656438712e-13 MirTarget -0.132445297015047 2.33568059728177e-10 NA NA NA hsa-miR-769-5p SMAD3 0.564871766265874 8.16695101656941e-10 -0.590930154862025 2.18041656438712e-13 miRNATAP -0.121091427985316 6.14487597806327e-05 NA NA NA hsa-miR-106b-5p SMAD4 1.22477789913175 2.31787213143326e-32 -0.624967182926059 1.70248077700642e-24 mirMAP;miRNATAP -0.132593131707842 2.60050027244317e-11 NA NA NA hsa-miR-146b-5p SMAD4 0.631041661167954 6.20366593452965e-08 -0.624967182926059 1.70248077700642e-24 PITA;miRanda;miRNATAP -0.13881112685924 1.84558785229961e-14 21874046;26883911 MicroRNA miR 146b 5p regulates signal transduction of TGF β by repressing SMAD4 in thyroid cancer; A computational search revealed that miR-146b-5p putatively binds to the 3' untranslated region UTR of SMAD4 an important member of the transforming growth factor β TGF-β signaling pathway; Luciferase reporter assay confirmed the direct binding of miR-146b-5p on the SMAD4 3'UTR; Specific inhibition of miR-146b-5p with a locked nucleic acid-modified anti-miR-146b oligonucleotide significantly increased SMAD4 levels in the human papillary carcinoma cell lines TPC-1 and BCPAP; The overexpression of miR-146b-5p in normal rat follicular PCCL3 cells decreased SMAD4 levels and disrupted TGF-β signal transduction;The overexpression of SMAD4 in BCPAP cells a validated target of miR-146b-5p and key protein in the TGF-β signaling pathway inhibited migration similarly to the effects observed with the antagomiR 146b-5p ; thyroid cancer;thyroid cancer hsa-miR-155-5p SMAD4 1.09766314984151 4.55650930885814e-15 -0.624967182926059 1.70248077700642e-24 miRNAWalker2_validate -0.114314883374695 1.83733755300191e-14 27626488 Here we demonstrated that TGF-β1 elevated the expression of miR-155 in colorectal cancer cells through SMAD3 and SMAD4 colorectal cancer hsa-miR-21-3p SMAD4 2.17476065946878 5.15299442583591e-75 -0.624967182926059 1.70248077700642e-24 mirMAP -0.142251679213528 1.79438322002583e-18 NA NA NA hsa-miR-27a-3p SMAD4 0.388496361379095 1.42373532086331e-05 -0.624967182926059 1.70248077700642e-24 MirTarget -0.107318887613883 7.95509636261065e-06 NA NA NA hsa-miR-32-5p SMAD4 1.38676603945192 2.29428299685976e-34 -0.624967182926059 1.70248077700642e-24 mirMAP -0.104053876543456 9.38449586813502e-09 NA NA NA hsa-miR-361-5p SMAD4 -0.0996867547900457 0.095428250126326 -0.624967182926059 1.70248077700642e-24 mirMAP -0.13420862344236 0.000247319809078657 NA NA NA hsa-miR-589-5p SMAD4 0.367182541239722 1.67804815542873e-05 -0.624967182926059 1.70248077700642e-24 miRNATAP -0.184456440754787 1.53364140974385e-13 NA NA NA hsa-miR-93-5p SMAD4 1.01788600209314 1.24312921618126e-21 -0.624967182926059 1.70248077700642e-24 miRNAWalker2_validate;mirMAP;miRNATAP -0.118636275861089 1.4710971943885e-09 NA NA NA hsa-let-7c-5p SMC1A -1.9415540533505 9.55250745007793e-48 0.332003162386777 2.55339979674107e-06 MirTarget -0.134887257980383 1.166774753247e-15 NA NA NA hsa-miR-101-3p SMC1A -0.126035286271986 0.145997832808138 0.332003162386777 2.55339979674107e-06 mirMAP -0.122546303506262 1.31489268612342e-05 NA NA NA hsa-miR-195-3p SMC1A -1.49582726452416 6.53261924105147e-40 0.332003162386777 2.55339979674107e-06 mirMAP -0.131967828634751 7.78482009158894e-11 NA NA NA hsa-miR-214-3p SMC1A -0.523705501275844 0.000211299789901139 0.332003162386777 2.55339979674107e-06 mirMAP -0.119648773845855 2.18429792312674e-12 NA NA NA hsa-miR-218-5p SMC1A -1.02621788318234 2.9221925445771e-23 0.332003162386777 2.55339979674107e-06 mirMAP -0.127615957876639 2.16822168807622e-08 NA NA NA hsa-miR-320a SMC1A -0.287921276129346 0.00141693637596294 0.332003162386777 2.55339979674107e-06 miRNAWalker2_validate -0.104467401937942 0.000107244701602372 NA NA NA hsa-miR-376c-3p SMC1A -1.23221625820254 6.08631316990405e-17 0.332003162386777 2.55339979674107e-06 mirMAP -0.100118454966962 6.3732673101846e-10 NA NA NA hsa-miR-340-5p SMC3 1.0857159627596 4.94471062546756e-24 -0.127265292078836 0.0670406127230421 miRNAWalker2_validate -0.149320252650635 2.60506584787157e-12 NA NA NA hsa-miR-361-5p SMC3 -0.0996867547900457 0.095428250126326 -0.127265292078836 0.0670406127230421 miRanda -0.260532162173104 7.84158818999235e-11 NA NA NA hsa-miR-107 STAG1 0.678998026350662 2.56224148930538e-16 -0.619829084277215 3.83376771553184e-11 miRanda;miRNATAP -0.257482713229171 1.88906645226651e-11 NA NA NA hsa-miR-128-3p STAG1 0.90296715955238 9.925204823863e-23 -0.619829084277215 3.83376771553184e-11 miRNAWalker2_validate -0.182482859995743 1.08370171254056e-07 NA NA NA hsa-miR-181a-5p STAG1 0.635863607630183 6.72486918157744e-11 -0.619829084277215 3.83376771553184e-11 miRNATAP -0.270985038996813 8.21021465834727e-17 NA NA NA hsa-miR-181b-5p STAG1 1.22749257795094 1.21998198830919e-27 -0.619829084277215 3.83376771553184e-11 miRNATAP -0.232125112876742 2.77638816320191e-17 NA NA NA hsa-miR-542-3p STAG1 0.568822103820889 8.5699075257651e-07 -0.619829084277215 3.83376771553184e-11 miRanda -0.194125480983161 2.34752908682072e-12 NA NA NA hsa-miR-96-5p STAG1 3.24596558166606 1.92296159041707e-98 -0.619829084277215 3.83376771553184e-11 TargetScan;miRNATAP -0.10025084146953 7.42338601520624e-08 NA NA NA hsa-miR-140-3p STAG2 -1.25844395244141 5.29222651039892e-33 -0.45824296739927 2.14317343940316e-11 MirTarget;PITA;miRNATAP -0.132039244172403 8.62316300304226e-10 NA NA NA hsa-miR-181a-5p STAG2 0.635863607630183 6.72486918157744e-11 -0.45824296739927 2.14317343940316e-11 miRNAWalker2_validate -0.204165672615861 6.98192164805347e-18 NA NA NA hsa-miR-21-5p STAG2 2.32007501846389 3.08394781855554e-137 -0.45824296739927 2.14317343940316e-11 miRNAWalker2_validate;MirTarget;miRNATAP -0.238585426475483 1.76104366677348e-30 NA NA NA hsa-miR-361-5p STAG2 -0.0996867547900457 0.095428250126326 -0.45824296739927 2.14317343940316e-11 miRanda -0.199216225143335 6.95332541877447e-07 NA NA NA hsa-miR-365a-3p TFDP1 -1.45032725192851 2.37888098061118e-37 0.475732630523186 1.02158117512193e-10 MirTarget -0.119562336866465 2.06776358163436e-08 NA NA NA hsa-miR-101-3p TFDP2 -0.126035286271986 0.145997832808138 -0.167222078165723 0.0148084925747518 mirMAP -0.111848427996868 3.97989678823534e-05 NA NA NA hsa-miR-29c-3p TFDP2 -0.0652732378039769 0.563774115756922 -0.167222078165723 0.0148084925747518 mirMAP -0.131866507884001 1.72590610095086e-10 NA NA NA hsa-miR-34c-5p TFDP2 -0.0896438810345765 0.557016551646841 -0.167222078165723 0.0148084925747518 miRNATAP -0.106991567483602 2.58746832485074e-12 NA NA NA hsa-miR-744-5p TGFB1 0.114590984077262 0.312916425462546 0.9572932995293 2.60884198670166e-26 miRNAWalker2_validate;miRNATAP -0.166126823806423 2.82828117413693e-09 NA NA NA hsa-miR-107 TGFB2 0.678998026350662 2.56224148930538e-16 -0.568239705690126 0.00206510120463672 miRanda -0.401875565283925 8.76701815465238e-08 NA NA NA hsa-miR-141-3p TGFB2 2.99777540204168 1.26370498493024e-78 -0.568239705690126 0.00206510120463672 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.201139839320628 1.72029232417547e-08 NA NA NA hsa-miR-148b-3p TGFB2 1.0552576751879 1.6679285705231e-29 -0.568239705690126 0.00206510120463672 MirTarget -0.422618628558287 7.82755899138552e-11 NA NA NA hsa-miR-149-5p TGFB2 0.218233101703391 0.261629158371175 -0.568239705690126 0.00206510120463672 MirTarget;miRNATAP -0.129221359501958 7.02534131250114e-05 NA NA NA hsa-miR-193a-3p TGFB2 0.310617999804917 0.00477640270974957 -0.568239705690126 0.00206510120463672 MirTarget;miRanda;miRNATAP -0.385790006047712 1.31529188795393e-11 NA NA NA hsa-miR-193b-3p TGFB2 -0.0550374855074773 0.65382485898551 -0.568239705690126 0.00206510120463672 MirTarget;miRNATAP -0.171503498781225 0.000913844156376696 NA NA NA hsa-miR-200a-3p TGFB2 2.55218480823434 2.96135446816238e-51 -0.568239705690126 0.00206510120463672 MirTarget;miRNATAP -0.157197308079383 7.61768751897913e-06 25813153 Tumor suppressive microRNA 200a inhibits renal cell carcinoma development by directly targeting TGFB2; By performing quantitative real-time PCR ELISA and luciferase reporter assays transforming growth factor beta2 TGFB2 was validated as a direct target gene of miR-200a; Moreover siRNA-mediated knockdown of TGFB2 partially phenocopied the effect of miR-200a overexpression; These results suggest that miR-200a suppresses RCC development via directly targeting TGFB2 indicating that miR-200a may present a novel target for diagnostic and therapeutic strategies in RCC kidney renal cell cancer hsa-miR-29b-3p TGFB2 0.438847962603729 6.46722433236121e-05 -0.568239705690126 0.00206510120463672 miRTarBase;MirTarget;miRNATAP -0.435812547346718 1.64777033866721e-14 NA NA NA hsa-miR-29c-3p TGFB2 -0.0652732378039769 0.563774115756922 -0.568239705690126 0.00206510120463672 MirTarget;miRNATAP -0.393270636676739 1.42982951467692e-12 NA NA NA hsa-miR-301a-3p TGFB2 1.32170168375632 2.12280368957514e-15 -0.568239705690126 0.00206510120463672 MirTarget;miRNATAP -0.168650734197616 6.85924013793372e-06 NA NA NA hsa-miR-330-3p TGFB2 0.432728362037032 0.00041335506960812 -0.568239705690126 0.00206510120463672 miRNATAP -0.169099911709115 0.00123359688318399 NA NA NA hsa-miR-330-5p TGFB2 0.626063225953928 3.42215028606779e-09 -0.568239705690126 0.00206510120463672 miRanda -0.231096330328837 9.82035598821339e-05 NA NA NA hsa-miR-331-5p TGFB2 0.682437632502949 4.10871642662371e-11 -0.568239705690126 0.00206510120463672 miRNATAP -0.256828592209254 2.39839780265118e-05 NA NA NA hsa-miR-375 TGFB2 2.09893673049766 1.68351780396203e-16 -0.568239705690126 0.00206510120463672 miRNAWalker2_validate -0.118032596246175 1.14664596099986e-06 NA NA NA hsa-miR-429 TGFB2 2.84108892259147 3.88520896426515e-64 -0.568239705690126 0.00206510120463672 miRNATAP -0.113931562701627 0.00112595441618086 NA NA NA hsa-miR-454-3p TGFB2 1.28177672191095 6.84024979484587e-21 -0.568239705690126 0.00206510120463672 MirTarget;miRNATAP -0.21652241903686 1.80168797038491e-06 NA NA NA hsa-miR-590-3p TGFB2 1.27438512890514 1.03164723481469e-23 -0.568239705690126 0.00206510120463672 mirMAP -0.218778123275247 1.55472558560304e-05 NA NA NA hsa-miR-590-5p TGFB2 0.746515607868274 8.51300479640125e-09 -0.568239705690126 0.00206510120463672 miRanda;miRNATAP -0.127583678067132 0.00859946694127918 NA NA NA hsa-let-7a-3p TGFB3 0.466622567891891 3.70886257943079e-07 0.82398957056453 1.83180841509129e-11 MirTarget -0.23002281448221 5.95409654478238e-07 NA NA NA hsa-let-7f-1-3p TGFB3 0.37532726250321 0.00156021688753682 0.82398957056453 1.83180841509129e-11 MirTarget -0.195594535331808 6.10557486170201e-08 NA NA NA hsa-miR-151a-5p TGFB3 0.509210376738198 3.17540030607215e-07 0.82398957056453 1.83180841509129e-11 MirTarget -0.460270915838936 5.41462985077644e-29 NA NA NA hsa-miR-26b-3p TGFB3 -0.62588114643887 3.30712936204727e-06 0.82398957056453 1.83180841509129e-11 MirTarget -0.166318643088715 1.09180542813277e-07 NA NA NA hsa-miR-29a-3p TGFB3 -0.699539666833076 1.13935003139957e-13 0.82398957056453 1.83180841509129e-11 miRNAWalker2_validate -0.215592947893623 1.26387377494944e-06 NA NA NA hsa-miR-29b-3p TGFB3 0.438847962603729 6.46722433236121e-05 0.82398957056453 1.83180841509129e-11 miRTarBase -0.300724044682202 2.93536952356929e-15 NA NA NA hsa-miR-511-5p TGFB3 -2.27545475897362 3.84085514050558e-36 0.82398957056453 1.83180841509129e-11 MirTarget -0.161630488068991 4.28099557548626e-13 NA NA NA hsa-miR-590-3p TGFB3 1.27438512890514 1.03164723481469e-23 0.82398957056453 1.83180841509129e-11 miRanda -0.276040958504426 1.7943368211393e-16 NA NA NA hsa-miR-629-3p TGFB3 1.25035919247365 3.91361135469024e-14 0.82398957056453 1.83180841509129e-11 MirTarget -0.184738491466436 9.18913270065683e-13 NA NA NA hsa-miR-139-5p TTK -3.25846663863766 2.62018989415003e-112 2.89352341653616 8.36295862849794e-61 miRanda -0.617617104777334 6.89212472369163e-66 NA NA NA hsa-miR-103a-3p WEE1 0.610673390034345 1.63113920514646e-12 -0.446519002168864 6.2795140571094e-07 miRNAWalker2_validate -0.112802476293424 0.00146201821866812 NA NA NA hsa-miR-107 WEE1 0.678998026350662 2.56224148930538e-16 -0.446519002168864 6.2795140571094e-07 miRanda -0.165371571294453 6.65055861102689e-06 NA NA NA hsa-miR-128-3p WEE1 0.90296715955238 9.925204823863e-23 -0.446519002168864 6.2795140571094e-07 miRNAWalker2_validate;miRTarBase;MirTarget -0.116427839408343 0.000385508903462461 NA NA NA hsa-miR-15a-5p WEE1 0.812445324157528 4.50263417099822e-20 -0.446519002168864 6.2795140571094e-07 MirTarget;miRNATAP -0.21969606684801 9.51948534968059e-11 NA NA NA hsa-miR-16-5p WEE1 0.46835991343556 1.91125356547776e-06 -0.446519002168864 6.2795140571094e-07 miRNAWalker2_validate;MirTarget;miRNATAP -0.103721097540326 0.000936391247320309 NA NA NA hsa-miR-221-3p WEE1 -0.317970198201501 0.00910855267413448 -0.446519002168864 6.2795140571094e-07 miRNAWalker2_validate -0.133591996067991 1.16385656648322e-07 NA NA NA hsa-miR-27a-3p WEE1 0.388496361379095 1.42373532086331e-05 -0.446519002168864 6.2795140571094e-07 miRTarBase;MirTarget -0.177233946437478 2.5121153609079e-07 NA NA NA hsa-miR-27b-3p WEE1 -0.0796803270437447 0.410503155574393 -0.446519002168864 6.2795140571094e-07 miRTarBase;MirTarget -0.106962528348254 0.000846853910573952 NA NA NA hsa-miR-218-5p YWHAB -1.02621788318234 2.9221925445771e-23 0.367736029126437 1.14326902549126e-12 MirTarget;miRNATAP -0.118771072777071 1.2025708808827e-12 NA NA NA hsa-miR-361-5p YWHAB -0.0996867547900457 0.095428250126326 0.367736029126437 1.14326902549126e-12 MirTarget;PITA;miRanda;miRNATAP -0.129790382733719 1.94479562657361e-05 NA NA NA hsa-miR-26a-5p YWHAE -0.481180084102235 1.82368246174758e-10 0.0789078821698794 0.139244898488797 miRNAWalker2_validate;miRNATAP -0.139062156125765 6.21839958682607e-09 NA NA NA hsa-miR-181c-5p YWHAG 0.574847839298605 4.51287502066478e-07 -0.30496627096666 3.16855379814272e-06 MirTarget;miRNATAP -0.145586859940849 6.31211340218828e-14 NA NA NA hsa-miR-181d-5p YWHAG 0.782618466877349 1.2821116358212e-09 -0.30496627096666 3.16855379814272e-06 MirTarget -0.103217848799385 1.84401651957152e-09 NA NA NA hsa-miR-200b-3p YWHAG 2.11744072703209 1.66710572104191e-43 -0.30496627096666 3.16855379814272e-06 MirTarget;TargetScan -0.11952750278469 2.04909339347489e-18 NA NA NA hsa-miR-200c-3p YWHAG 2.07038651806183 6.84613386286599e-51 -0.30496627096666 3.16855379814272e-06 MirTarget;miRNATAP -0.115098762293347 2.44122702999837e-14 NA NA NA hsa-miR-30a-5p YWHAG -0.392489994825279 0.00954894667761676 -0.30496627096666 3.16855379814272e-06 miRNATAP -0.130408882982876 3.06189502357674e-19 NA NA NA hsa-miR-34c-3p YWHAG 0.213037310586265 0.144107566901292 -0.30496627096666 3.16855379814272e-06 MirTarget;PITA -0.101761318229923 6.09583697264274e-11 NA NA NA hsa-miR-361-3p YWHAG -0.0370446538644886 0.624902392829872 -0.30496627096666 3.16855379814272e-06 miRNATAP -0.123033020131908 3.98096255501155e-05 NA NA NA hsa-miR-195-5p YWHAH -1.47508108420708 2.20685847368258e-38 0.574547913335089 6.31677198141686e-23 MirTarget;miRNATAP -0.154571273062705 3.79154556881082e-20 NA NA NA hsa-miR-361-5p YWHAH -0.0996867547900457 0.095428250126326 0.574547913335089 6.31677198141686e-23 miRanda -0.122118229637353 0.00045156556380787 NA NA NA hsa-miR-497-5p YWHAH -1.4667331575679 5.49909921822638e-36 0.574547913335089 6.31677198141686e-23 MirTarget;miRNATAP -0.101887170785079 8.76599010415193e-10 NA NA NA hsa-miR-195-5p YWHAQ -1.47508108420708 2.20685847368258e-38 0.14614608366116 0.0210037506575042 MirTarget;miRNATAP -0.131078204286072 2.84212998538795e-13 NA NA NA hsa-let-7b-5p YWHAZ -0.54215483448257 7.21347617597858e-08 0.614503695418861 6.69168275891896e-13 miRNAWalker2_validate -0.143693415048529 9.14380074121916e-07 NA NA NA hsa-miR-140-3p YWHAZ -1.25844395244141 5.29222651039892e-33 0.614503695418861 6.69168275891896e-13 MirTarget;PITA;miRNATAP -0.220682872816636 1.53890225766904e-16 NA NA NA hsa-miR-195-3p YWHAZ -1.49582726452416 6.53261924105147e-40 0.614503695418861 6.69168275891896e-13 MirTarget -0.217318055382634 8.6510493117177e-19 NA NA NA hsa-miR-199a-5p YWHAZ -0.314703593105081 0.00909304983051124 0.614503695418861 6.69168275891896e-13 miRanda -0.142636123966747 5.50463507912081e-09 NA NA NA hsa-miR-199b-5p YWHAZ -1.37022396448377 3.25758057539223e-26 0.614503695418861 6.69168275891896e-13 miRanda -0.177217586869737 5.92745522971954e-16 NA NA NA hsa-miR-30a-5p YWHAZ -0.392489994825279 0.00954894667761676 0.614503695418861 6.69168275891896e-13 miRNAWalker2_validate;MirTarget;miRNATAP -0.183528380744408 8.33049950582494e-22 NA NA NA hsa-miR-34c-5p YWHAZ -0.0896438810345765 0.557016551646841 0.614503695418861 6.69168275891896e-13 miRanda -0.122122109832999 2.94590640777635e-10 NA NA NA hsa-miR-495-3p YWHAZ -1.67685437612894 1.70634429769052e-34 0.614503695418861 6.69168275891896e-13 mirMAP -0.129022570922436 4.47948910436123e-10 NA NA NA