miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-335-3p BMP2 2.5197689063267 2.20084506976733e-09 -0.330988655536076 0.460129330608628 mirMAP -0.232514170508169 0.0012787026131925 NA NA NA hsa-miR-338-3p BMP7 -0.959276231066179 0.0191473351014091 0.767143453660681 0.311782695394875 miRanda -0.539549909974716 3.17130115467174e-05 NA NA NA hsa-miR-3614-3p BMP7 0.816988052098069 0.0143572924352078 0.767143453660681 0.311782695394875 mirMAP -0.559588260418171 0.000793664362435681 NA NA NA hsa-miR-362-3p BMP7 -0.0349414695893027 0.913780708043777 0.767143453660681 0.311782695394875 miRanda -0.473280486099214 0.00508089454645054 NA NA NA hsa-miR-134-5p EPB41L5 0.565477776815981 0.109621868298098 -0.498748128668495 0.0239509307807049 MirTarget -0.142128523887078 0.00137286827781268 NA NA NA hsa-miR-152-3p EPB41L5 0.436002345388935 0.161701199884702 -0.498748128668495 0.0239509307807049 MirTarget -0.276648814477509 1.87391886467657e-08 NA NA NA hsa-miR-16-2-3p EPB41L5 1.8048179609245 2.83095715136409e-09 -0.498748128668495 0.0239509307807049 mirMAP -0.137962828533997 0.00568628391039343 NA NA NA hsa-miR-224-3p EPB41L5 1.52422171450716 0.00650463542340912 -0.498748128668495 0.0239509307807049 mirMAP -0.144180357716781 1.38781934542276e-06 NA NA NA hsa-miR-328-3p EPB41L5 -0.380419131085598 0.160877064911118 -0.498748128668495 0.0239509307807049 MirTarget -0.171013019282991 0.00341521878386205 NA NA NA hsa-miR-33a-5p EPB41L5 0.407757858040717 0.321429014317207 -0.498748128668495 0.0239509307807049 mirMAP -0.147374430360966 0.000101471388021094 NA NA NA hsa-miR-34c-3p EPB41L5 2.25273698056457 9.06191072601281e-05 -0.498748128668495 0.0239509307807049 mirMAP -0.150900065741244 9.14016253397834e-09 NA NA NA hsa-miR-142-3p FAM83D 1.32364054836498 0.0001537753622128 0.56867163408775 0.0849631362954195 miRanda -0.205159344174238 0.00193736425365218 NA NA NA hsa-miR-192-5p FAM83D 0.0809146624034405 0.941057093528709 0.56867163408775 0.0849631362954195 miRNAWalker2_validate -0.141410746337488 3.54473551077374e-12 NA NA NA hsa-miR-19b-3p FAM83D 0.759818275708988 0.00652779573186786 0.56867163408775 0.0849631362954195 miRNATAP -0.273495239983566 0.00112246363082937 NA NA NA hsa-miR-429 FAM83D 1.40182602301928 0.00900426780286475 0.56867163408775 0.0849631362954195 miRanda -0.171574779855698 6.48307533751077e-05 NA NA NA hsa-miR-186-5p FGFR2 0.149964130725901 0.434709542998771 -0.0989978709215018 0.814042278338263 miRNAWalker2_validate -0.416290327670683 0.00939242147576651 NA NA NA hsa-miR-326 FGFR2 -0.429748586406214 0.2629894124021 -0.0989978709215018 0.814042278338263 miRanda -0.227787287684123 0.00384928442941226 NA NA NA hsa-miR-338-3p FGFR2 -0.959276231066179 0.0191473351014091 -0.0989978709215018 0.814042278338263 miRanda;miRNATAP -0.196178980077981 0.00698122481372059 NA NA NA hsa-miR-130b-3p FOXF2 1.32714007211004 4.78676252285191e-05 -0.83383001747337 0.0265853555210985 miRNATAP -0.346219210725021 1.49343437922965e-05 NA NA NA hsa-miR-142-3p FOXF2 1.32364054836498 0.0001537753622128 -0.83383001747337 0.0265853555210985 miRanda -0.372813971228237 4.9100061609644e-07 NA NA NA hsa-miR-182-5p FOXF2 0.887369486030646 0.0310640781418789 -0.83383001747337 0.0265853555210985 miRNAWalker2_validate;miRNATAP -0.227935777404123 0.000422960940551467 25738520 miR 182 promotes cell growth and invasion by targeting forkhead box F2 transcription factor in colorectal cancer; In the present study we aimed to investigate the role of miR-182 in colorectal cancer CRC and identify the regulation of FoxF2 by miR-182; The direct binding of miR-182 to the 3' untranslated region 3'UTR of FoxF2 mRNA was confirmed using a luciferase reporter gene assay colorectal cancer hsa-miR-19a-3p FOXF2 1.26669687448473 0.000105972838514412 -0.83383001747337 0.0265853555210985 miRNATAP -0.493917517923083 2.27334333153188e-10 NA NA NA hsa-miR-19b-3p FOXF2 0.759818275708988 0.00652779573186786 -0.83383001747337 0.0265853555210985 miRNATAP -0.617334884904687 1.75887771108779e-11 NA NA NA hsa-miR-200b-3p FOXF2 0.974577911407732 0.0595020056914543 -0.83383001747337 0.0265853555210985 TargetScan -0.262340936986815 1.98299481120105e-07 25798833 The miR 200 family and the miR 183~96~182 cluster target Foxf2 to inhibit invasion and metastasis in lung cancers; We therefore identified a novel mechanism whereby the miR-200 family and the miR-183~96~182 cluster inhibit lung cancer invasion and metastasis by targeting Foxf2 metastasis lung cancer hsa-miR-200c-3p FOXF2 1.28185685499076 0.00369777635539177 -0.83383001747337 0.0265853555210985 miRNATAP -0.324573529396868 2.93102733089069e-08 NA NA NA hsa-miR-26b-5p FOXF2 -0.301646326928219 0.160081421968103 -0.83383001747337 0.0265853555210985 miRNAWalker2_validate -0.455618063872328 0.000321296097142742 NA NA NA hsa-miR-3607-3p FOXF2 0.522750552658156 0.0842510989344654 -0.83383001747337 0.0265853555210985 miRNATAP -0.359972034306092 4.39960700561714e-05 NA NA NA hsa-miR-3662 FOXF2 1.82780708047676 0.0054036501346178 -0.83383001747337 0.0265853555210985 mirMAP -0.196809598766801 0.000152769151737596 NA NA NA hsa-miR-429 FOXF2 1.40182602301928 0.00900426780286475 -0.83383001747337 0.0265853555210985 PITA;miRanda;miRNATAP -0.261954927330119 5.62111532325881e-08 NA NA NA hsa-miR-454-3p FOXF2 0.625199142970745 0.0134890997402741 -0.83383001747337 0.0265853555210985 miRNATAP -0.300823122773405 0.00484503415557275 NA NA NA hsa-miR-590-3p FOXF2 1.11654983899947 0.000160782154924864 -0.83383001747337 0.0265853555210985 PITA;miRanda -0.429793095011288 1.07489782521611e-06 NA NA NA hsa-miR-96-5p FOXF2 1.14243043653372 0.00942969392739105 -0.83383001747337 0.0265853555210985 TargetScan;miRNATAP -0.237643785724754 0.000165104447157946 NA NA NA hsa-miR-101-3p GSK3B -0.451263906815861 0.0283387250173031 0.173686703054757 0.358761637442374 miRNATAP -0.309746385838821 1.76772309214892e-06 NA NA NA hsa-miR-212-3p GSK3B 0.960352937108106 0.00133449812322732 0.173686703054757 0.358761637442374 mirMAP;miRNATAP -0.157580688036431 0.000373666664591505 NA NA NA hsa-miR-26a-5p GSK3B -0.384110714440647 0.0442498636014044 0.173686703054757 0.358761637442374 miRNAWalker2_validate;miRNATAP -0.297404702806196 2.62046086511681e-05 NA NA NA hsa-miR-26b-5p GSK3B -0.301646326928219 0.160081421968103 0.173686703054757 0.358761637442374 miRNATAP -0.202543608293146 0.00135911800763895 NA NA NA hsa-miR-29a-3p GSK3B -0.113012156986374 0.615005009685815 0.173686703054757 0.358761637442374 miRNATAP -0.237953626141529 7.3117565138463e-05 NA NA NA hsa-miR-29b-3p GSK3B -0.230693226193598 0.367461626035234 0.173686703054757 0.358761637442374 miRTarBase;miRNATAP -0.139976205675035 0.00818133109022919 NA NA NA hsa-miR-29c-3p GSK3B -1.62454036584589 5.38376515586029e-07 0.173686703054757 0.358761637442374 miRNATAP -0.149008148419369 0.000186841384822779 NA NA NA hsa-miR-30d-3p GSK3B -0.545113326540761 0.0433733076874155 0.173686703054757 0.358761637442374 miRNATAP -0.134805668946892 0.00688448679166308 NA NA NA hsa-miR-340-5p GSK3B -0.164941927483643 0.529910509321278 0.173686703054757 0.358761637442374 mirMAP -0.184933292640156 0.000302021889990012 NA NA NA hsa-let-7a-3p HGF 0.503048155002889 0.0411145454335299 -0.376531570639447 0.550491511103826 mirMAP -0.818691872864681 6.02516795359655e-06 NA NA NA hsa-let-7b-3p HGF 0.21838629112113 0.296038413622566 -0.376531570639447 0.550491511103826 mirMAP -0.849666066489082 9.15421436976392e-05 NA NA NA hsa-miR-141-3p HGF 1.45548825076434 0.00115958850961764 -0.376531570639447 0.550491511103826 MirTarget;TargetScan -0.486507123512748 4.89226986811595e-07 NA NA NA hsa-miR-203a-3p HGF 1.44736908507496 0.0394116388736904 -0.376531570639447 0.550491511103826 MirTarget -0.518782559309176 3.06524300072984e-19 NA NA NA hsa-miR-224-3p HGF 1.52422171450716 0.00650463542340912 -0.376531570639447 0.550491511103826 mirMAP -0.463827973319244 4.02273153083653e-08 NA NA NA hsa-miR-33a-3p HGF 0.347011402017138 0.321709379745392 -0.376531570639447 0.550491511103826 mirMAP -0.544350013780391 4.75735535202373e-05 NA NA NA hsa-miR-34c-5p HGF 2.20632574870337 0.000379662996168678 -0.376531570639447 0.550491511103826 miRanda -0.305112726593846 1.53268570245237e-05 NA NA NA hsa-miR-3682-3p HGF 1.96838261925327 4.94885331227292e-06 -0.376531570639447 0.550491511103826 mirMAP -0.404404600221883 0.000774301762513964 NA NA NA hsa-miR-590-5p HGF 1.04171442093217 0.000272475544954865 -0.376531570639447 0.550491511103826 miRanda -0.577047667344204 0.000185605077930884 NA NA NA hsa-miR-944 HGF 3.33123095809751 0.0177835044930391 -0.376531570639447 0.550491511103826 mirMAP -0.251904679029854 1.61296788568438e-12 NA NA NA hsa-miR-106b-5p HIF1A 1.70863907461894 2.04074794107142e-08 0.837030068372412 0.000839528175139087 MirTarget -0.167802822306102 0.00333492904025455 NA NA NA hsa-miR-107 HIF1A 0.904627575346218 4.67936495073904e-05 0.837030068372412 0.000839528175139087 miRNAWalker2_validate;miRTarBase;miRanda -0.359531659282077 6.20183058633611e-06 NA NA NA hsa-miR-139-5p HIF1A -1.83374360776637 1.22019901002824e-09 0.837030068372412 0.000839528175139087 miRanda -0.162264370983123 0.00469202590041469 NA NA NA hsa-miR-151a-3p HIF1A 1.00322719901751 7.20903658270795e-06 0.837030068372412 0.000839528175139087 MirTarget -0.234458462521455 0.00333486662982671 NA NA NA hsa-miR-320c HIF1A 0.455072851945474 0.240613785444485 0.837030068372412 0.000839528175139087 miRanda -0.146570914616352 0.00656355498345466 NA NA NA hsa-miR-330-3p HIF1A 0.798460296022179 0.00746538156533435 0.837030068372412 0.000839528175139087 MirTarget;PITA -0.177923264725505 0.00313165494038062 NA NA NA hsa-miR-338-3p HIF1A -0.959276231066179 0.0191473351014091 0.837030068372412 0.000839528175139087 MirTarget;PITA;miRanda -0.1816114503828 2.64079547478836e-05 NA NA NA hsa-miR-338-5p HIF1A -1.19659203838734 0.0100316010080496 0.837030068372412 0.000839528175139087 MirTarget;PITA;miRNATAP -0.142083993703647 0.000195627392940844 NA NA NA hsa-miR-361-5p HIF1A 0.407725414130987 0.0181260969156347 0.837030068372412 0.000839528175139087 miRanda -0.306375208776554 0.00431549109334927 NA NA NA hsa-miR-660-5p HIF1A -0.0206552819434673 0.938868734063643 0.837030068372412 0.000839528175139087 MirTarget -0.28396448451383 2.10152340867086e-05 NA NA NA hsa-miR-129-5p HMGA2 -2.56914016541176 2.36237896095709e-06 3.29022066144686 1.4946291628467e-05 miRanda;mirMAP -0.395375428421379 7.18167111585831e-05 NA NA NA hsa-miR-195-3p HMGA2 -1.34779269408059 2.01619826639376e-05 3.29022066144686 1.4946291628467e-05 mirMAP -0.481386939478582 0.00544474498767817 NA NA NA hsa-miR-195-5p HMGA2 -0.907998841926297 0.00150511564650591 3.29022066144686 1.4946291628467e-05 MirTarget -0.574673575929259 0.00284266988055356 NA NA NA hsa-miR-23b-3p HMGA2 -0.286465516491361 0.18664668472995 3.29022066144686 1.4946291628467e-05 mirMAP -0.699599170887866 0.00715695840932712 NA NA NA hsa-miR-29b-2-5p HMGA2 -1.7015307882027 2.84239251703401e-10 3.29022066144686 1.4946291628467e-05 mirMAP -1.01218169047566 1.40966187205613e-07 NA NA NA hsa-miR-30d-5p HMGA2 -0.5492586056147 0.0140125082460125 3.29022066144686 1.4946291628467e-05 mirMAP -0.905143632219791 0.000272703317314888 NA NA NA hsa-miR-30e-3p HMGA2 -0.913131357083321 7.29096855615228e-06 3.29022066144686 1.4946291628467e-05 MirTarget -0.884861609382722 0.00105824633248414 NA NA NA hsa-miR-664a-3p HMGA2 -0.83041219170254 0.000136267547251167 3.29022066144686 1.4946291628467e-05 mirMAP -1.08476792952589 1.56192988012522e-05 NA NA NA hsa-miR-664a-5p HMGA2 -0.134698715850215 0.624350535385503 3.29022066144686 1.4946291628467e-05 MirTarget -0.546556253811885 0.00812260621807993 NA NA NA hsa-miR-29b-2-5p HNRNPAB -1.7015307882027 2.84239251703401e-10 0.58736338039132 0.000303789810128464 MirTarget -0.1333010548125 0.00125561103103831 NA NA NA hsa-miR-7-1-3p LEF1 0.709309110750947 0.0412301737463194 1.62041926135487 4.56974660298132e-05 mirMAP -0.215763577578317 0.00939527019662836 NA NA NA hsa-miR-221-3p LIMS1 1.33496247538338 3.82022531235275e-07 0.0610663956286661 0.735391768086693 miRNAWalker2_validate;MirTarget -0.139437864386477 0.00326753192302172 NA NA NA hsa-miR-222-3p LIMS1 1.39382731585819 9.98182478024671e-07 0.0610663956286661 0.735391768086693 MirTarget -0.115013588780951 0.00870298503789044 NA NA NA hsa-miR-30b-5p LIMS1 -0.430720743745757 0.0593564057320791 0.0610663956286661 0.735391768086693 MirTarget -0.188777771229001 0.000796009438632585 NA NA NA hsa-miR-30d-5p LIMS1 -0.5492586056147 0.0140125082460125 0.0610663956286661 0.735391768086693 MirTarget -0.174459356679118 0.00242649847086453 NA NA NA hsa-miR-590-3p LIMS1 1.11654983899947 0.000160782154924864 0.0610663956286661 0.735391768086693 miRNAWalker2_validate;miRanda -0.118853299202122 0.00532620880394037 NA NA NA hsa-miR-126-5p NOG 0.41765430251855 0.0753161203651532 -1.02902055182595 0.091574937725035 mirMAP;miRNATAP -0.755310980620566 4.71870231386366e-05 NA NA NA hsa-miR-144-3p NOG -0.13309578176575 0.798245647923351 -1.02902055182595 0.091574937725035 miRNATAP -0.262913329938093 0.00180561019174322 NA NA NA hsa-miR-148b-3p NOG 0.295175884456199 0.17466422420702 -1.02902055182595 0.091574937725035 MirTarget -0.629344994917056 0.00196895031315866 NA NA NA hsa-miR-200b-3p NOG 0.974577911407732 0.0595020056914543 -1.02902055182595 0.091574937725035 MirTarget;TargetScan -0.536247611410024 1.89923770240193e-11 NA NA NA hsa-miR-200c-3p NOG 1.28185685499076 0.00369777635539177 -1.02902055182595 0.091574937725035 MirTarget;miRNATAP -0.525789119498179 2.9262586744068e-08 NA NA NA hsa-miR-338-5p NOG -1.19659203838734 0.0100316010080496 -1.02902055182595 0.091574937725035 miRNATAP -0.262333662617846 0.00474672126417801 NA NA NA hsa-miR-362-3p NOG -0.0349414695893027 0.913780708043777 -1.02902055182595 0.091574937725035 miRanda;miRNATAP -0.456606791654822 0.000752714936635676 NA NA NA hsa-miR-375 NOG -2.94506033785642 0.00570147601654791 -1.02902055182595 0.091574937725035 miRanda -0.209580144756538 9.36285238787859e-08 NA NA NA hsa-miR-429 NOG 1.40182602301928 0.00900426780286475 -1.02902055182595 0.091574937725035 MirTarget;PITA;miRanda;miRNATAP -0.451675555951267 6.180337532319e-09 NA NA NA hsa-miR-101-3p NOTCH1 -0.451263906815861 0.0283387250173031 1.03457165666178 0.000183884001409579 MirTarget -0.410465637505241 2.51749676202837e-05 NA NA NA hsa-miR-139-5p NOTCH1 -1.83374360776637 1.22019901002824e-09 1.03457165666178 0.000183884001409579 PITA;miRanda;miRNATAP -0.244586591874221 0.000104547125974859 27173050;25149074;26299922;27738333;24885920 miR 139 5p sensitizes colorectal cancer cells to 5 fluorouracil by targeting NOTCH 1;MiR 139 5p inhibits migration and invasion of colorectal cancer by downregulating AMFR and NOTCH1; Mechanistic investigations revealed that miR-139-5p suppress CRC cell invasion and metastasis by targeting AMFR and NOTCH1;MiR 139 5p inhibits the biological function of breast cancer cells by targeting Notch1 and mediates chemosensitivity to docetaxel; MiR-139-5p expression in MCF-7 MCF-7/Doc cells and in selected breast cancer tissue samples was confirmed by real-time PCR; cell viability was analyzed by Cell Counting Kit-8 assay; apoptosis and cell cycle were analyzed by flow cytometry; control of metastasis and invasion of breast cancer cells was measured by transwell assay; expression of Notch1 was measured by western blot; a luciferase reporter vector was constructed to identify the miR-139-5p target gene; MiR-139-5p not only attenuated the development of breast cancer cells but also mediated drug-resistance by regulating the expression of the downstream target gene Notch1;MiR 139 5p reverses CD44+/CD133+ associated multidrug resistance by downregulating NOTCH1 in colorectal carcinoma cells; We also identified NOTCH1 an important protein for stem cell maintenance and function as a direct target of miR-139-5p both in vitro and in a knockout mouse model; Notch1 expression was upregulated in tumor samples and inversely correlated with expression of miR-139-5p; Silencing NOTCH1 exerted an effect similar to overexpression of miR-139-5p by inhibiting the CD44+ and CD133+ population and reversing the drug-resistant phenotype; In conclusion miR-139-5p downregulated NOTCH1 signaling to reverse CD44+/CD133+-associated MDR in colorectal cancer cells;microRNA 139 5p exerts tumor suppressor function by targeting NOTCH1 in colorectal cancer ;metastasis;metastasis;drug resistance;drug resistance; colorectal cancer;colorectal cancer;breast cancer;colorectal cancer;colorectal cancer hsa-miR-30a-5p NOTCH1 -1.71922855140016 3.20574349285256e-07 1.03457165666178 0.000183884001409579 miRNAWalker2_validate;miRTarBase;miRNATAP -0.237487101914633 3.11096506547323e-05 NA NA NA hsa-miR-30b-5p NOTCH1 -0.430720743745757 0.0593564057320791 1.03457165666178 0.000183884001409579 miRNATAP -0.359873257715373 3.94249576060544e-05 NA NA NA hsa-miR-30c-5p NOTCH1 -0.983130268805942 4.60419218706127e-05 1.03457165666178 0.000183884001409579 miRNATAP -0.328013194317787 5.53414847804594e-05 23974200 We identified NOTCH1 as a direct target of miR-30c; Finally a block of miR-30c prevents C/EBPα-induced downregulation of Notch1 protein and leads to a reduced CD11b expression in myeloid differentiation; Our study presents the first evidence that C/EBPα miR-30c and Notch1 together play a critical role in granulocytic differentiation and AML and particularly in AML with CEBPA mutations differentiation acute myeloid leukemia hsa-miR-30d-5p NOTCH1 -0.5492586056147 0.0140125082460125 1.03457165666178 0.000183884001409579 miRNATAP -0.28107214113315 0.0018063783049975 NA NA NA hsa-miR-32-5p NOTCH1 0.415247682945382 0.106458022460373 1.03457165666178 0.000183884001409579 miRNATAP -0.250670532538739 0.00133267590955028 NA NA NA hsa-miR-326 NOTCH1 -0.429748586406214 0.2629894124021 1.03457165666178 0.000183884001409579 miRNAWalker2_validate;miRTarBase -0.166722970723998 0.00149451512551307 NA NA NA hsa-miR-151a-3p RBPJ 1.00322719901751 7.20903658270795e-06 -0.391590660016552 0.00734579053071903 miRNATAP -0.123274000838898 0.00733175896093517 NA NA NA hsa-miR-15b-5p RBPJ 1.62046407540723 5.42152621571078e-09 -0.391590660016552 0.00734579053071903 MirTarget -0.120655004149257 0.000768046676379928 NA NA NA hsa-miR-200c-3p RBPJ 1.28185685499076 0.00369777635539177 -0.391590660016552 0.00734579053071903 mirMAP -0.106878469693801 2.72559665286448e-06 NA NA NA hsa-miR-107 SNAI2 0.904627575346218 4.67936495073904e-05 0.8679564879757 0.163674726451342 miRanda -0.956073669477844 9.87262308538113e-07 NA NA NA hsa-miR-126-5p SNAI2 0.41765430251855 0.0753161203651532 0.8679564879757 0.163674726451342 MirTarget -0.698491882102722 0.000239984015988638 NA NA NA hsa-miR-140-5p SNAI2 0.208193069681326 0.303002433893804 0.8679564879757 0.163674726451342 miRanda -0.709926892739581 0.00155086520600903 25322669;27597739 Down regulation of miR 140 induces EMT and promotes invasion by targeting Slug in esophageal cancer; Slug a target gene of miR-140 was examined by luciferase assay and Western blot; miR-140 may regulate the cell invasion of EC via controlling Slug expression;Mechanistically Unigene56159 could directly bind to miR-140-5p and effectively act as a competing endogenous RNA ceRNA for miR-140-5p to de-repress the expression of the target gene Slug ; esophageal cancer;liver cancer hsa-miR-148b-3p SNAI2 0.295175884456199 0.17466422420702 0.8679564879757 0.163674726451342 miRNAWalker2_validate -0.880275520162378 1.78722551968974e-05 NA NA NA hsa-miR-200b-3p SNAI2 0.974577911407732 0.0595020056914543 0.8679564879757 0.163674726451342 TargetScan -0.481058558788609 5.92706791955422e-09 NA NA NA hsa-miR-335-3p SNAI2 2.5197689063267 2.20084506976733e-09 0.8679564879757 0.163674726451342 mirMAP -0.308182854003903 0.00222866592387318 NA NA NA hsa-miR-3614-5p SNAI2 1.10426689932954 0.00706308396674599 0.8679564879757 0.163674726451342 MirTarget -0.422502185264929 9.17833069626897e-05 NA NA NA hsa-miR-375 SNAI2 -2.94506033785642 0.00570147601654791 0.8679564879757 0.163674726451342 miRanda -0.414986060133483 2.04706689528243e-32 NA NA NA hsa-miR-429 SNAI2 1.40182602301928 0.00900426780286475 0.8679564879757 0.163674726451342 PITA;miRanda;miRNATAP -0.392670133124033 1.01237240041389e-06 NA NA NA hsa-miR-532-5p SNAI2 0.313080805824184 0.252248939356301 0.8679564879757 0.163674726451342 PITA -1.32274651095458 1.34874826226459e-18 NA NA NA hsa-miR-1-3p SOX9 -2.66410453456934 1.50620580537836e-05 1.26108367036486 0.00806168277725881 MirTarget -0.179796207167646 0.000863271165410352 NA NA NA hsa-miR-129-5p SOX9 -2.56914016541176 2.36237896095709e-06 1.26108367036486 0.00806168277725881 miRanda -0.244069781362561 7.03027779443274e-05 NA NA NA hsa-miR-145-5p SOX9 -1.75133578902314 1.54965572197748e-05 1.26108367036486 0.00806168277725881 miRNATAP -0.367143003432363 5.98792200501052e-06 25145279;24631504 The epigenetic regulation of SOX9 by miR 145 in human chondrosarcoma; We hypothesized that the expression of miR-145 is low in chondrosarcoma leading to decreased transcriptional control of SOX9 the master regulator of chondrogenesis and downstream activation of the transcription factor ETV5;Ectopic expression of miR-145 in turn regulates SOX9 expression through the binding to specific seed motifs; Together these results suggest that miR-145 is a novel target of PPARγ acts as a tumor suppressor in CRC cell lines and is a key regulator of intestinal cell differentiation by directly targeting SOX9 a marker of undifferentiated progenitors in the colonic crypts ;differentiation sarcoma;colorectal cancer hsa-miR-199a-5p SOX9 0.371973504507027 0.232661597228763 1.26108367036486 0.00806168277725881 miRNAWalker2_validate -0.313924874680494 0.00434663474205556 NA NA NA hsa-miR-9-3p SOX9 0.330346058941473 0.541111939982661 1.26108367036486 0.00806168277725881 miRNATAP -0.354835897454858 2.77684445595393e-08 NA NA NA hsa-miR-139-5p TGFB1 -1.83374360776637 1.22019901002824e-09 0.921978024389205 0.015443067273438 miRanda -0.231228229661 0.00779949032347728 NA NA NA hsa-miR-29b-3p TGFB1 -0.230693226193598 0.367461626035234 0.921978024389205 0.015443067273438 miRTarBase -0.456958304413375 1.70622144738106e-05 NA NA NA hsa-miR-141-3p TGFB2 1.45548825076434 0.00115958850961764 0.531711555933475 0.237271821958403 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.310711996035385 7.80220336778334e-06 NA NA NA hsa-miR-148a-3p TGFB2 -1.53721533763578 3.55533747293117e-05 0.531711555933475 0.237271821958403 MirTarget;miRNATAP -0.220405364068209 0.00926503682050518 NA NA NA hsa-miR-148b-3p TGFB2 0.295175884456199 0.17466422420702 0.531711555933475 0.237271821958403 MirTarget -0.467759048012148 0.00176540723814519 NA NA NA hsa-miR-200a-3p TGFB2 0.717826667295984 0.193912116506827 0.531711555933475 0.237271821958403 MirTarget;miRNATAP -0.252010151933484 9.49127408816544e-06 25813153 Tumor suppressive microRNA 200a inhibits renal cell carcinoma development by directly targeting TGFB2; By performing quantitative real-time PCR ELISA and luciferase reporter assays transforming growth factor beta2 TGFB2 was validated as a direct target gene of miR-200a; Moreover siRNA-mediated knockdown of TGFB2 partially phenocopied the effect of miR-200a overexpression; These results suggest that miR-200a suppresses RCC development via directly targeting TGFB2 indicating that miR-200a may present a novel target for diagnostic and therapeutic strategies in RCC kidney renal cell cancer hsa-miR-203a-3p TGFB2 1.44736908507496 0.0394116388736904 0.531711555933475 0.237271821958403 MirTarget -0.165925482602356 0.000218164630138837 NA NA NA hsa-miR-32-3p TGFB2 0.583525764322974 0.11837203008551 0.531711555933475 0.237271821958403 mirMAP -0.25717146688254 0.00779413036125543 NA NA NA hsa-miR-330-3p TGFB2 0.798460296022179 0.00746538156533435 0.531711555933475 0.237271821958403 miRNATAP -0.296195247581737 0.00574751539933769 NA NA NA hsa-miR-33a-3p TGFB2 0.347011402017138 0.321709379745392 0.531711555933475 0.237271821958403 MirTarget;mirMAP -0.39918681868845 2.86864367014074e-05 NA NA NA hsa-miR-375 TGFB2 -2.94506033785642 0.00570147601654791 0.531711555933475 0.237271821958403 miRNAWalker2_validate -0.135378292973885 3.38653961690956e-06 NA NA NA hsa-miR-429 TGFB2 1.40182602301928 0.00900426780286475 0.531711555933475 0.237271821958403 miRNATAP -0.282945695650806 1.02668418456713e-06 NA NA NA hsa-miR-101-3p TGFBR1 -0.451263906815861 0.0283387250173031 -0.251712186913126 0.256800460803047 miRNAWalker2_validate;miRNATAP -0.334479809747145 1.26739295835297e-05 NA NA NA hsa-miR-126-5p TGFBR1 0.41765430251855 0.0753161203651532 -0.251712186913126 0.256800460803047 mirMAP;miRNATAP -0.196953631979334 0.00365598115607916 NA NA NA hsa-miR-128-3p TGFBR1 0.98280381420517 5.77641850797209e-05 -0.251712186913126 0.256800460803047 miRNAWalker2_validate;miRTarBase -0.244707904105477 0.000113112751777729 NA NA NA hsa-miR-130b-3p TGFBR1 1.32714007211004 4.78676252285191e-05 -0.251712186913126 0.256800460803047 miRNATAP -0.1828131710731 0.000100953415159321 NA NA NA hsa-miR-140-5p TGFBR1 0.208193069681326 0.303002433893804 -0.251712186913126 0.256800460803047 miRNAWalker2_validate;PITA;miRanda;miRNATAP -0.231595932892087 0.00360519586226147 NA NA NA hsa-miR-142-5p TGFBR1 1.55592486377018 6.69269968016779e-06 -0.251712186913126 0.256800460803047 mirMAP -0.145948144144052 0.00101240741188477 NA NA NA hsa-miR-32-3p TGFBR1 0.583525764322974 0.11837203008551 -0.251712186913126 0.256800460803047 mirMAP;miRNATAP -0.12860507498816 0.006711968086731 NA NA NA hsa-miR-330-3p TGFBR1 0.798460296022179 0.00746538156533435 -0.251712186913126 0.256800460803047 mirMAP;miRNATAP -0.202440596846935 0.000103947872399532 NA NA NA hsa-miR-429 TGFBR1 1.40182602301928 0.00900426780286475 -0.251712186913126 0.256800460803047 miRanda;miRNATAP -0.103531890165161 0.000330036442446001 NA NA NA hsa-miR-769-5p TGFBR1 1.14821899306381 1.27143750879772e-06 -0.251712186913126 0.256800460803047 PITA;miRNATAP -0.21341868517347 0.00105603441804849 NA NA NA hsa-miR-15a-5p TGFBR3 1.03783090449383 7.40334108980898e-07 -2.5453489359487 2.55855407656975e-07 MirTarget;miRNATAP -0.717762702969539 2.23693689380416e-05 NA NA NA hsa-miR-15b-5p TGFBR3 1.62046407540723 5.42152621571078e-09 -2.5453489359487 2.55855407656975e-07 MirTarget;miRNATAP -0.558319586365568 7.28016246351776e-06 NA NA NA hsa-miR-16-2-3p TGFBR3 1.8048179609245 2.83095715136409e-09 -2.5453489359487 2.55855407656975e-07 mirMAP -0.483674400691069 2.0877588558894e-05 NA NA NA hsa-miR-16-5p TGFBR3 1.00515772948091 5.33912942007619e-06 -2.5453489359487 2.55855407656975e-07 MirTarget;miRNATAP -0.679314806633212 2.47983231355558e-05 NA NA NA hsa-miR-182-5p TGFBR3 0.887369486030646 0.0310640781418789 -2.5453489359487 2.55855407656975e-07 miRNATAP -0.290896100418916 0.000889552903550763 NA NA NA hsa-miR-185-3p TGFBR3 1.33711019171256 3.45756583967985e-05 -2.5453489359487 2.55855407656975e-07 MirTarget;miRNATAP -0.363968822089794 0.000966212518334601 NA NA NA hsa-miR-18a-3p TGFBR3 2.35188582849667 1.39401350286321e-08 -2.5453489359487 2.55855407656975e-07 MirTarget -0.385102077244319 3.5046360319332e-06 NA NA NA hsa-miR-18a-5p TGFBR3 2.20211504140984 1.78678887916334e-09 -2.5453489359487 2.55855407656975e-07 MirTarget -0.433710499252048 3.48292958396425e-06 NA NA NA hsa-miR-193b-3p TGFBR3 0.281752012268679 0.451258902263119 -2.5453489359487 2.55855407656975e-07 miRNAWalker2_validate;MirTarget;miRNATAP -0.498828173102988 1.48286052396892e-07 NA NA NA hsa-miR-21-5p TGFBR3 1.75445050487988 2.41825549682022e-23 -2.5453489359487 2.55855407656975e-07 miRNAWalker2_validate -1.1197191216922 5.22599460161761e-10 NA NA NA hsa-miR-222-5p TGFBR3 1.87968474330782 1.11743009485711e-06 -2.5453489359487 2.55855407656975e-07 MirTarget -0.279904853457402 0.0021888634533865 NA NA NA hsa-miR-23a-3p TGFBR3 1.10685926969665 3.16223452471768e-08 -2.5453489359487 2.55855407656975e-07 MirTarget;mirMAP -0.761242920104668 1.57215702647613e-05 NA NA NA hsa-miR-27a-3p TGFBR3 1.29886998470345 2.68986118553486e-08 -2.5453489359487 2.55855407656975e-07 MirTarget;miRNATAP -0.735484806135868 7.54795324711613e-07 NA NA NA hsa-miR-296-5p TGFBR3 0.932146077883618 0.0602370559607489 -2.5453489359487 2.55855407656975e-07 MirTarget -0.258685442678788 0.00062347209493997 NA NA NA hsa-miR-323b-3p TGFBR3 1.13581624461921 0.0214847831286342 -2.5453489359487 2.55855407656975e-07 miRNATAP -0.242636472096206 0.00326963836690031 NA NA NA hsa-miR-335-3p TGFBR3 2.5197689063267 2.20084506976733e-09 -2.5453489359487 2.55855407656975e-07 mirMAP -0.267681362921701 0.00113634123062514 NA NA NA hsa-miR-424-5p TGFBR3 1.08509868581983 0.000420473853818268 -2.5453489359487 2.55855407656975e-07 MirTarget;miRNATAP -0.592962460480752 2.08106075810596e-07 NA NA NA hsa-miR-455-5p TGFBR3 1.20462751989145 6.74386011867484e-05 -2.5453489359487 2.55855407656975e-07 miRanda -0.828622912452922 1.24229170584621e-13 NA NA NA hsa-miR-484 TGFBR3 0.71327898984355 0.00233605130771196 -2.5453489359487 2.55855407656975e-07 MirTarget;miRNATAP -0.567949380275866 0.00023819450324354 NA NA NA hsa-miR-590-3p TGFBR3 1.11654983899947 0.000160782154924864 -2.5453489359487 2.55855407656975e-07 MirTarget;miRanda;mirMAP -0.327080534392386 0.00716732139849971 NA NA NA hsa-miR-590-5p TGFBR3 1.04171442093217 0.000272475544954865 -2.5453489359487 2.55855407656975e-07 miRanda -0.439937187151358 0.000441953048943132 NA NA NA hsa-miR-944 TGFBR3 3.33123095809751 0.0177835044930391 -2.5453489359487 2.55855407656975e-07 mirMAP -0.121565213683814 5.40521086016591e-05 NA NA NA hsa-miR-140-3p WNT5A -0.296251775392129 0.127539826012144 1.41889465887496 0.00302272108132253 MirTarget;miRNATAP -0.654997547844657 0.000272516279902339 NA NA NA hsa-miR-148a-5p WNT5A -0.69329616490858 0.0793012233740369 1.41889465887496 0.00302272108132253 mirMAP -0.266432697712533 0.00213233612269223 NA NA NA hsa-miR-186-5p WNT5A 0.149964130725901 0.434709542998771 1.41889465887496 0.00302272108132253 miRNAWalker2_validate;mirMAP;miRNATAP -0.596923529656949 0.00113609892095247 NA NA NA hsa-miR-2110 WNT5A 0.759864042760204 0.0723961390557655 1.41889465887496 0.00302272108132253 MirTarget -0.233877228710552 0.00444047447373778 NA NA NA hsa-miR-29a-5p WNT5A 0.585084040404152 0.023014129158495 1.41889465887496 0.00302272108132253 mirMAP -0.458967614840154 0.000602375776214386 NA NA NA hsa-miR-30a-3p WNT5A -1.73205137750899 3.2425754511091e-07 1.41889465887496 0.00302272108132253 mirMAP -0.280674702827158 0.00442239689083578 NA NA NA hsa-miR-30a-5p WNT5A -1.71922855140016 3.20574349285256e-07 1.41889465887496 0.00302272108132253 miRNAWalker2_validate;mirMAP -0.30560196566196 0.00207001162461839 NA NA NA hsa-miR-30b-5p WNT5A -0.430720743745757 0.0593564057320791 1.41889465887496 0.00302272108132253 mirMAP -0.425807828312639 0.00526169426726682 NA NA NA hsa-miR-30c-5p WNT5A -0.983130268805942 4.60419218706127e-05 1.41889465887496 0.00302272108132253 mirMAP -0.441333932103179 0.0017917746829392 NA NA NA hsa-miR-30d-3p WNT5A -0.545113326540761 0.0433733076874155 1.41889465887496 0.00302272108132253 mirMAP -0.420494750254843 0.000995090928789905 NA NA NA hsa-miR-30d-5p WNT5A -0.5492586056147 0.0140125082460125 1.41889465887496 0.00302272108132253 mirMAP -0.485615482740843 0.00175018462113529 NA NA NA hsa-miR-326 WNT5A -0.429748586406214 0.2629894124021 1.41889465887496 0.00302272108132253 miRanda -0.338021912325719 0.000172032350996894 NA NA NA hsa-miR-330-5p WNT5A 0.488365986827708 0.0512207630808233 1.41889465887496 0.00302272108132253 miRanda -0.360290139732328 0.00941314185696927 NA NA NA hsa-miR-375 WNT5A -2.94506033785642 0.00570147601654791 1.41889465887496 0.00302272108132253 miRNATAP -0.151859982937763 1.13834427953838e-06 NA NA NA hsa-miR-577 WNT5A 0.911619788986754 0.2256062124148 1.41889465887496 0.00302272108132253 mirMAP;miRNATAP -0.158155731877324 0.000655709824150159 NA NA NA hsa-miR-7-1-3p WNT5A 0.709309110750947 0.0412301737463194 1.41889465887496 0.00302272108132253 mirMAP -0.431985130260792 9.26141562033071e-06 NA NA NA