miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7a-5p AKT2 -1.37014061604018 3.11451492971224e-14 0.158500088541505 0.113504798741429 TargetScan -0.119930037553526 1.13227688326527e-06 NA NA NA hsa-miR-29a-3p AKT2 0.101650412194573 0.573201097011668 0.158500088541505 0.113504798741429 MirTarget -0.104368014677354 4.26511869332683e-05 24076586 Furthermore a feed-back loop comprising of c-Myc miR-29 family and Akt2 were found in myeloid leukemogenesis acute myeloid leukemia hsa-miR-106b-5p AKT3 1.47447672652218 1.32004094930462e-13 -1.44031241124732 2.576504600149e-09 miRNATAP -0.158920731526324 0.00425859940487133 NA NA NA hsa-miR-107 AKT3 0.658676029898313 5.11480446318819e-07 -1.44031241124732 2.576504600149e-09 PITA;miRanda -0.256548300142307 0.00309702957622585 NA NA NA hsa-miR-146b-5p AKT3 1.0922867893808 5.63754607494775e-06 -1.44031241124732 2.576504600149e-09 miRNAWalker2_validate -0.14508398550335 0.00188822517544197 NA NA NA hsa-miR-15a-5p AKT3 1.62575353599172 1.55312121019827e-19 -1.44031241124732 2.576504600149e-09 miRNAWalker2_validate;miRTarBase;miRNATAP -0.412918804091755 4.08840965026726e-12 NA NA NA hsa-miR-16-5p AKT3 0.749619098384047 4.11649450706988e-06 -1.44031241124732 2.576504600149e-09 miRNAWalker2_validate;miRTarBase;miRNATAP -0.269698520974258 9.94440318719177e-05 NA NA NA hsa-miR-17-5p AKT3 2.07078488653279 2.77403038572568e-19 -1.44031241124732 2.576504600149e-09 TargetScan;miRNATAP -0.217476886844258 3.56953935954486e-06 NA NA NA hsa-miR-181a-5p AKT3 -0.375429731222937 0.0562142867129802 -1.44031241124732 2.576504600149e-09 miRNATAP -0.22550600060725 9.19470016250579e-05 NA NA NA hsa-miR-181b-5p AKT3 0.668793269169928 0.000239998092406404 -1.44031241124732 2.576504600149e-09 miRNATAP -0.367498754199467 2.09865276667175e-09 NA NA NA hsa-miR-20a-5p AKT3 2.64649625616975 5.1469418982085e-27 -1.44031241124732 2.576504600149e-09 miRNATAP -0.24430728120197 1.27608550819212e-08 NA NA NA hsa-miR-22-3p AKT3 1.42501909916631 1.72295005910055e-25 -1.44031241124732 2.576504600149e-09 miRNATAP -0.259390140878921 0.0010937362716222 NA NA NA hsa-miR-29b-2-5p AKT3 0.345881055247341 0.194842633194187 -1.44031241124732 2.576504600149e-09 mirMAP -0.181342398720756 1.80199534450665e-05 NA NA NA hsa-miR-29b-3p AKT3 3.10527711861309 3.01242507282711e-32 -1.44031241124732 2.576504600149e-09 miRNATAP -0.267243460090773 1.17871192498365e-11 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-3065-5p AKT3 0.653308707552535 0.0999497219778851 -1.44031241124732 2.576504600149e-09 mirMAP -0.18242132898273 2.34990243224026e-09 NA NA NA hsa-miR-362-5p AKT3 0.658947634569393 0.0243306847205756 -1.44031241124732 2.576504600149e-09 PITA;TargetScan;miRNATAP -0.229571357984291 4.43564207755877e-09 NA NA NA hsa-miR-542-3p AKT3 1.62226640768239 2.6427102465476e-10 -1.44031241124732 2.576504600149e-09 miRanda -0.186790699816246 1.44501888663791e-05 NA NA NA hsa-miR-93-5p AKT3 1.50844106515467 1.83836866996875e-12 -1.44031241124732 2.576504600149e-09 miRNATAP -0.251105283811718 1.01733106411986e-06 NA NA NA hsa-miR-146b-5p ARRB1 1.0922867893808 5.63754607494775e-06 -1.39937041514285 1.13546096655032e-11 miRanda -0.114161430360667 0.00436136331891293 NA NA NA hsa-miR-219a-1-3p ARRB1 0.42818839093396 0.0892433909993089 -1.39937041514285 1.13546096655032e-11 MirTarget -0.109524449525217 0.00579814691053272 NA NA NA hsa-miR-22-3p ARRB1 1.42501909916631 1.72295005910055e-25 -1.39937041514285 1.13546096655032e-11 MirTarget -0.275953154489764 4.77756911720126e-05 NA NA NA hsa-miR-361-5p ARRB1 0.21454431962475 0.0800957579368424 -1.39937041514285 1.13546096655032e-11 MirTarget;miRanda -0.216828504711511 0.00729419279546035 NA NA NA hsa-miR-455-3p ARRB1 0.591830122989234 0.0444780564859344 -1.39937041514285 1.13546096655032e-11 MirTarget -0.127626704453604 0.000100690631630921 NA NA NA hsa-miR-550a-5p ARRB1 0.59977150019756 0.0314775340172755 -1.39937041514285 1.13546096655032e-11 MirTarget -0.119369718389259 0.000604894055096218 NA NA NA hsa-miR-671-5p ARRB1 2.24156654191798 2.10433241567652e-14 -1.39937041514285 1.13546096655032e-11 MirTarget -0.228922711761184 1.5339810228756e-09 NA NA NA hsa-let-7a-3p ATF2 0.167285443861993 0.431834813181487 0.0108252986583377 0.936889208236278 MirTarget;mirMAP;miRNATAP -0.128835404212926 9.65527356851969e-05 NA NA NA hsa-miR-140-3p ATF2 -1.11373309124537 8.35257079443689e-14 0.0108252986583377 0.936889208236278 MirTarget;PITA;miRNATAP -0.155363141988392 0.000162576373114767 NA NA NA hsa-miR-15a-5p ATF2 1.62575353599172 1.55312121019827e-19 0.0108252986583377 0.936889208236278 miRNAWalker2_validate -0.194111389282878 5.03172071069784e-09 NA NA NA hsa-miR-181a-5p ATF2 -0.375429731222937 0.0562142867129802 0.0108252986583377 0.936889208236278 mirMAP;miRNATAP -0.15087869419291 2.07790173520328e-06 NA NA NA hsa-miR-222-3p ATF2 0.0327210697409583 0.881937768109611 0.0108252986583377 0.936889208236278 MirTarget -0.131684536657296 3.51039503254779e-06 NA NA NA hsa-miR-26b-5p ATF2 0.72362441215247 4.7794659748036e-05 0.0108252986583377 0.936889208236278 MirTarget;miRNATAP -0.122447422445475 0.000494610369299413 21901137 Coordinated regulation of ATF2 by miR 26b in γ irradiated lung cancer cells; Concurrent analysis of time-series mRNA and microRNA profiles uncovered that expression of miR-26b was down regulated and its target activating transcription factor 2 ATF2 mRNA was up regulated in γ-irradiated H1299 cells; IR in miR-26b overexpressed H1299 cells could not induce expression of ATF2; From these results we concluded that IR-induced up-regulation of ATF2 was coordinately enhanced by suppression of miR-26b in lung cancer cells which may enhance the effect of IR in the MAPK signaling pathway lung cancer hsa-miR-30b-5p ATF2 0.358144314839612 0.138026229059594 0.0108252986583377 0.936889208236278 mirMAP -0.178384785370869 2.48045163615783e-12 NA NA NA hsa-miR-30c-5p ATF2 -0.327319105755825 0.123595832152687 0.0108252986583377 0.936889208236278 mirMAP -0.260700722002115 5.109462900737e-20 NA NA NA hsa-miR-374a-5p ATF2 -0.197027254874826 0.298080902192861 0.0108252986583377 0.936889208236278 mirMAP -0.161311101413889 1.41360976287521e-05 NA NA NA hsa-miR-10a-5p BDNF 0.790595816051606 0.000593731378445468 -3.58120361925577 1.66270299378731e-16 MirTarget;miRNATAP -0.279836886583095 0.00181387070495345 NA NA NA hsa-miR-146b-5p BDNF 1.0922867893808 5.63754607494775e-06 -3.58120361925577 1.66270299378731e-16 miRanda -0.328233255541106 0.000115785817710226 NA NA NA hsa-miR-148a-5p BDNF 1.45633512586855 1.81792463521257e-08 -3.58120361925577 1.66270299378731e-16 mirMAP -0.242376055234495 0.00212193071916532 NA NA NA hsa-miR-155-5p BDNF 0.813513839059142 0.000608282725633232 -3.58120361925577 1.66270299378731e-16 miRNATAP -0.23365712136721 0.00730981706859504 NA NA NA hsa-miR-15a-5p BDNF 1.62575353599172 1.55312121019827e-19 -3.58120361925577 1.66270299378731e-16 MirTarget;miRNATAP -0.299122819876483 0.00718936325191299 26581909 MicroRNA 15a 5p suppresses cancer proliferation and division in human hepatocellular carcinoma by targeting BDNF; BDNF was then overexpressed in HepG2 and SNU-182 cells to evaluate its selective effect on miR-15a-5p in HCC modulation; MiR-15a-5p selectively and negatively regulated BDNF at both gene and protein levels in HCC cells; Forced overexpression of BDNF effectively reversed the tumor suppressive functions of miR-15a-5p on HCC proliferation and cell division in vitro; Our study demonstrated that miR-15a-5p is a tumor suppressor in HCC and its regulation is through BDNF in HCC liver cancer hsa-miR-182-5p BDNF 3.21839823004635 5.13049145201115e-39 -3.58120361925577 1.66270299378731e-16 MirTarget;miRNATAP -0.493312713509266 7.77762857641849e-11 NA NA NA hsa-miR-210-3p BDNF 4.89285936864822 4.81769290932762e-28 -3.58120361925577 1.66270299378731e-16 miRNAWalker2_validate;miRTarBase -0.223383828264906 2.32341714099671e-07 NA NA NA hsa-miR-29b-1-5p BDNF 1.71024742617744 3.64915691793611e-09 -3.58120361925577 1.66270299378731e-16 mirMAP -0.254685357058655 0.000278466889584519 NA NA NA hsa-miR-30e-5p BDNF 1.60414100786743 3.78951090573667e-19 -3.58120361925577 1.66270299378731e-16 miRNATAP -0.435874001655586 8.84443032504441e-05 NA NA NA hsa-miR-7-1-3p BDNF 2.61364240402652 1.98959237815786e-32 -3.58120361925577 1.66270299378731e-16 MirTarget -0.301669237992761 0.00109301980491166 NA NA NA hsa-miR-199a-5p BRAF 1.3057193856884 2.38429382751645e-08 0.430269646481455 0.00362923920939546 miRanda -0.126145320292071 1.03462729304979e-05 NA NA NA hsa-miR-199b-5p BRAF 2.13822205171062 4.56262988762436e-15 0.430269646481455 0.00362923920939546 miRanda -0.109868089750526 5.08266642121306e-06 NA NA NA hsa-miR-29b-2-5p CACNA1A 0.345881055247341 0.194842633194187 0.0783083334601729 0.814619377565923 mirMAP -0.187633002954969 0.00112183150721283 NA NA NA hsa-miR-107 CACNA1C 0.658676029898313 5.11480446318819e-07 -1.13264525318144 1.64827906709005e-05 miRNATAP -0.428012097991579 4.04378379286335e-06 NA NA NA hsa-miR-148b-5p CACNA1C 1.39335695292409 2.13220380550073e-07 -1.13264525318144 1.64827906709005e-05 mirMAP -0.246809297608598 4.10338090562013e-06 NA NA NA hsa-miR-186-5p CACNA1C 0.852175445703945 6.88885738584309e-10 -1.13264525318144 1.64827906709005e-05 mirMAP -0.362356527438629 3.50196910715514e-05 NA NA NA hsa-miR-19a-3p CACNA1C 2.11776595911517 7.07663078397156e-10 -1.13264525318144 1.64827906709005e-05 MirTarget -0.174423925677542 2.6077064677566e-05 NA NA NA hsa-miR-19b-1-5p CACNA1C 1.71217036351784 3.28561659177495e-12 -1.13264525318144 1.64827906709005e-05 MirTarget -0.322038785653597 6.15459248920127e-09 NA NA NA hsa-miR-19b-3p CACNA1C 2.10868505662119 5.40846613768389e-17 -1.13264525318144 1.64827906709005e-05 MirTarget -0.185153033129457 0.000171944752896701 NA NA NA hsa-miR-200c-3p CACNA1C 0.380533388300368 0.0842181838538353 -1.13264525318144 1.64827906709005e-05 MirTarget -0.213658441050478 0.000114193304495079 NA NA NA hsa-miR-33a-5p CACNA1C 2.80127809675219 5.09053890529424e-12 -1.13264525318144 1.64827906709005e-05 MirTarget -0.184826875367139 2.94898121689524e-07 NA NA NA hsa-miR-421 CACNA1C 0.170525317701774 0.535277026680289 -1.13264525318144 1.64827906709005e-05 MirTarget;PITA;miRanda;miRNATAP -0.321092346366263 1.21696206846487e-11 NA NA NA hsa-miR-450b-5p CACNA1C 1.69248953402469 1.96052058003353e-07 -1.13264525318144 1.64827906709005e-05 PITA;miRNATAP -0.186532705963729 5.82412099745972e-06 NA NA NA hsa-miR-542-3p CACNA1C 1.62226640768239 2.6427102465476e-10 -1.13264525318144 1.64827906709005e-05 miRanda -0.19998480930038 1.65211142094798e-05 NA NA NA hsa-miR-589-3p CACNA1C 1.34253876396688 1.84935927493927e-05 -1.13264525318144 1.64827906709005e-05 MirTarget;mirMAP -0.117116522902473 0.00330771786769705 NA NA NA hsa-miR-7-1-3p CACNA1C 2.61364240402652 1.98959237815786e-32 -1.13264525318144 1.64827906709005e-05 MirTarget -0.217237125982874 6.30795569391338e-05 NA NA NA hsa-miR-877-5p CACNA1C -0.370234513208225 0.20670834111988 -1.13264525318144 1.64827906709005e-05 MirTarget -0.146690698814832 0.000437174841612043 NA NA NA hsa-miR-93-3p CACNA1C 1.07631808403007 1.63747525692813e-05 -1.13264525318144 1.64827906709005e-05 mirMAP -0.211267887595584 1.20372935323985e-05 NA NA NA hsa-miR-96-5p CACNA1C 3.0381097138467 4.40362891630201e-24 -1.13264525318144 1.64827906709005e-05 MirTarget;TargetScan -0.368917581004764 1.12789445722898e-17 NA NA NA hsa-let-7a-2-3p CACNA1D 1.34046246689099 0.000367955143268581 -1.17578800276405 0.00431507562542044 MirTarget -0.345375370470117 2.24328812016173e-12 NA NA NA hsa-let-7i-5p CACNA1D 0.605080599172936 1.48406814653206e-06 -1.17578800276405 0.00431507562542044 miRNATAP -0.484765988638838 0.00146890651596564 NA NA NA hsa-miR-134-5p CACNA1D 0.169332101696567 0.622858464530849 -1.17578800276405 0.00431507562542044 MirTarget -0.201679151255998 0.000255021591909941 NA NA NA hsa-miR-142-3p CACNA1D 3.98476449801341 1.56256182021111e-35 -1.17578800276405 0.00431507562542044 miRanda -0.253422366165759 3.3324113452072e-06 NA NA NA hsa-miR-542-3p CACNA1D 1.62226640768239 2.6427102465476e-10 -1.17578800276405 0.00431507562542044 miRanda -0.344368732449181 1.8599390506719e-06 NA NA NA hsa-miR-590-3p CACNA1D 0.83851360565783 0.00129224433453587 -1.17578800276405 0.00431507562542044 miRanda;miRNATAP -0.374207156215658 1.67980867125e-05 NA NA NA hsa-miR-629-5p CACNA1D 1.31657090341737 1.45711558652127e-12 -1.17578800276405 0.00431507562542044 MirTarget -0.478216775283858 1.58152619552315e-06 NA NA NA hsa-let-7a-5p CACNA1E -1.37014061604018 3.11451492971224e-14 1.61997771769256 0.000199986231006477 TargetScan;miRNATAP -0.574891579992724 1.08961563411076e-07 NA NA NA hsa-let-7b-5p CACNA1E -1.62016148171663 1.56547487335694e-15 1.61997771769256 0.000199986231006477 miRNATAP -0.40307847915734 2.75327750478965e-05 NA NA NA hsa-let-7e-5p CACNA1E -0.749418249305995 7.34668338492227e-05 1.61997771769256 0.000199986231006477 miRNATAP -0.407285843853158 0.000127859304220744 NA NA NA hsa-let-7f-5p CACNA1E -0.0523311272618407 0.83407808268787 1.61997771769256 0.000199986231006477 miRNATAP -0.254567881046881 0.00167079773520727 NA NA NA hsa-miR-125b-2-3p CACNA1E -1.71462405245374 1.47042341386638e-10 1.61997771769256 0.000199986231006477 mirMAP -0.239786057900701 0.00117793680524553 NA NA NA hsa-miR-1266-5p CACNA1E -0.289721391624349 0.281500764553995 1.61997771769256 0.000199986231006477 MirTarget -0.32663856558253 1.23948140638329e-05 NA NA NA hsa-miR-143-3p CACNA1E -1.21021691908494 5.70938667332876e-06 1.61997771769256 0.000199986231006477 miRNATAP -0.224044365052182 0.00281841650893037 NA NA NA hsa-miR-195-3p CACNA1E -1.33068822339418 6.65427393047357e-09 1.61997771769256 0.000199986231006477 mirMAP -0.242988055639593 0.00526775180744903 NA NA NA hsa-miR-195-5p CACNA1E -1.01577502605386 4.80814718341729e-05 1.61997771769256 0.000199986231006477 MirTarget -0.244824803663745 0.00385208885719192 NA NA NA hsa-miR-2110 CACNA1E -1.92124860612475 1.1464887721828e-12 1.61997771769256 0.000199986231006477 mirMAP -0.226615407975538 0.00207005370007659 NA NA NA hsa-miR-3065-3p CACNA1E 0.381740717819351 0.30795546546997 1.61997771769256 0.000199986231006477 MirTarget;miRNATAP -0.172850873423409 0.00132085231833428 NA NA NA hsa-miR-30a-3p CACNA1E -2.54042202792785 2.9111625410859e-18 1.61997771769256 0.000199986231006477 MirTarget;mirMAP;miRNATAP -0.320960727111494 1.20226205023255e-06 NA NA NA hsa-miR-30b-3p CACNA1E -1.20976737190106 2.63726511331003e-06 1.61997771769256 0.000199986231006477 mirMAP -0.260989026267266 0.000775419685809423 NA NA NA hsa-miR-30d-3p CACNA1E 0.00396376345349925 0.986457040013182 1.61997771769256 0.000199986231006477 MirTarget;mirMAP;miRNATAP -0.318528158312428 0.00104581272706195 NA NA NA hsa-miR-30e-3p CACNA1E -0.104420043859122 0.526240453209293 1.61997771769256 0.000199986231006477 MirTarget;mirMAP;miRNATAP -0.468906885624861 0.00014470292327269 NA NA NA hsa-miR-664a-5p CACNA1E -0.0936480603578111 0.662274905077117 1.61997771769256 0.000199986231006477 mirMAP -0.275372608937572 0.00463282208042562 NA NA NA hsa-miR-151a-3p CACNA1G 0.665271883054405 0.000281673348137154 -0.0253734894802433 0.952465256915734 MirTarget -0.341409709525347 0.00140231288707462 NA NA NA hsa-miR-590-3p CACNA1G 0.83851360565783 0.00129224433453587 -0.0253734894802433 0.952465256915734 miRanda -0.43776499237524 9.18816295245919e-07 NA NA NA hsa-miR-590-5p CACNA1G 2.07441240363458 4.95240551694843e-14 -0.0253734894802433 0.952465256915734 miRanda -0.225783724527001 0.0086560699743723 NA NA NA hsa-miR-629-3p CACNA1G 1.31892116211001 0.000114487182853678 -0.0253734894802433 0.952465256915734 MirTarget -0.221837937345915 0.000316833247750317 NA NA NA hsa-let-7a-5p CACNA1I -1.37014061604018 3.11451492971224e-14 1.04590083822976 0.0243362371924613 TargetScan;miRNATAP -0.515027138951135 8.07842124980554e-06 NA NA NA hsa-let-7b-5p CACNA1I -1.62016148171663 1.56547487335694e-15 1.04590083822976 0.0243362371924613 miRNATAP -0.390135851508111 0.000134847459141358 NA NA NA hsa-let-7e-5p CACNA1I -0.749418249305995 7.34668338492227e-05 1.04590083822976 0.0243362371924613 miRNATAP -0.327089062118771 0.00387022706297331 NA NA NA hsa-let-7f-5p CACNA1I -0.0523311272618407 0.83407808268787 1.04590083822976 0.0243362371924613 miRNATAP -0.275936285564746 0.00132396974644862 NA NA NA hsa-miR-664a-5p CACNA1I -0.0936480603578111 0.662274905077117 1.04590083822976 0.0243362371924613 mirMAP -0.336794426372883 0.00108548640835054 NA NA NA hsa-miR-103a-3p CACNA2D1 0.538497806383155 1.88134691850591e-05 -1.26894428990152 0.00468562348387855 miRNATAP -0.610791622731041 0.000232401874179767 NA NA NA hsa-miR-107 CACNA2D1 0.658676029898313 5.11480446318819e-07 -1.26894428990152 0.00468562348387855 PITA;miRanda;miRNATAP -0.554027876535255 0.000471546898699359 NA NA NA hsa-miR-141-3p CACNA2D1 3.36993755486106 5.42939251147195e-32 -1.26894428990152 0.00468562348387855 TargetScan -0.465645589872069 1.77259080171687e-12 NA NA NA hsa-miR-16-2-3p CACNA2D1 0.503964803530872 0.0263648405197492 -1.26894428990152 0.00468562348387855 mirMAP -0.272010935240178 0.00621950038894255 NA NA NA hsa-miR-16-5p CACNA2D1 0.749619098384047 4.11649450706988e-06 -1.26894428990152 0.00468562348387855 miRNAWalker2_validate -0.350453054379483 0.00592563587606449 NA NA NA hsa-miR-181a-5p CACNA2D1 -0.375429731222937 0.0562142867129802 -1.26894428990152 0.00468562348387855 mirMAP -0.319821212258882 0.00252450949518743 NA NA NA hsa-miR-181b-5p CACNA2D1 0.668793269169928 0.000239998092406404 -1.26894428990152 0.00468562348387855 mirMAP -0.509579480904267 6.78421115363218e-06 NA NA NA hsa-miR-182-5p CACNA2D1 3.21839823004635 5.13049145201115e-39 -1.26894428990152 0.00468562348387855 miRNATAP -0.280126297532479 0.000279259656913274 NA NA NA hsa-miR-200b-3p CACNA2D1 1.55157578247391 4.83790020897188e-09 -1.26894428990152 0.00468562348387855 TargetScan -0.421731304395922 2.955748223646e-08 NA NA NA hsa-miR-26b-5p CACNA2D1 0.72362441215247 4.7794659748036e-05 -1.26894428990152 0.00468562348387855 mirMAP -0.533505077972136 3.98110992515888e-06 NA NA NA hsa-miR-3065-5p CACNA2D1 0.653308707552535 0.0999497219778851 -1.26894428990152 0.00468562348387855 mirMAP -0.275895192975287 9.39153009012628e-07 NA NA NA hsa-miR-30d-3p CACNA2D1 0.00396376345349925 0.986457040013182 -1.26894428990152 0.00468562348387855 mirMAP -0.262760812597763 0.0085996652363654 NA NA NA hsa-miR-338-3p CACNA2D1 0.726843067232002 0.0506251324215494 -1.26894428990152 0.00468562348387855 miRanda -0.193704876175361 0.00048543409662379 NA NA NA hsa-miR-362-3p CACNA2D1 0.194097672030785 0.52808475179225 -1.26894428990152 0.00468562348387855 miRanda -0.325706562209354 0.000107559892708263 NA NA NA hsa-miR-450b-5p CACNA2D1 1.69248953402469 1.96052058003353e-07 -1.26894428990152 0.00468562348387855 mirMAP -0.251876832189587 0.000331331686891523 NA NA NA hsa-miR-576-5p CACNA2D1 1.02693643167056 1.14846964470173e-06 -1.26894428990152 0.00468562348387855 mirMAP -0.267245663696844 0.00614335656715093 NA NA NA hsa-miR-590-3p CACNA2D1 0.83851360565783 0.00129224433453587 -1.26894428990152 0.00468562348387855 mirMAP -0.24786185979421 0.00930316223356935 NA NA NA hsa-miR-96-5p CACNA2D1 3.0381097138467 4.40362891630201e-24 -1.26894428990152 0.00468562348387855 TargetScan;miRNATAP -0.432243217630285 7.3108948346751e-09 NA NA NA hsa-miR-10a-5p CACNA2D2 0.790595816051606 0.000593731378445468 -4.04922734123758 1.12027274781151e-11 mirMAP -0.409758585958963 0.000758420233796126 NA NA NA hsa-miR-1271-5p CACNA2D2 -0.0172769786790662 0.951102370899887 -4.04922734123758 1.12027274781151e-11 MirTarget -0.277627329608952 0.00617933084579083 NA NA NA hsa-miR-142-3p CACNA2D2 3.98476449801341 1.56256182021111e-35 -4.04922734123758 1.12027274781151e-11 miRanda -0.525487597991482 4.04263513597146e-11 NA NA NA hsa-miR-182-5p CACNA2D2 3.21839823004635 5.13049145201115e-39 -4.04922734123758 1.12027274781151e-11 miRNATAP -0.33550367706652 0.00135490689197185 NA NA NA hsa-miR-193a-3p CACNA2D2 0.549173467360291 0.0319030569365466 -4.04922734123758 1.12027274781151e-11 miRanda -0.812279501666674 3.53362194528229e-12 NA NA NA hsa-miR-205-5p CACNA2D2 1.45372157280932 0.0361802982284339 -4.04922734123758 1.12027274781151e-11 miRNATAP -0.120533892411245 0.00280543281238662 NA NA NA hsa-miR-22-5p CACNA2D2 1.71436244278242 9.85038001236064e-15 -4.04922734123758 1.12027274781151e-11 mirMAP -0.678379469327104 2.75118979667433e-08 NA NA NA hsa-miR-3607-3p CACNA2D2 2.4103172144469 2.69039449048047e-08 -4.04922734123758 1.12027274781151e-11 miRNATAP -0.17410531299834 0.00635228894804561 NA NA NA hsa-miR-455-3p CACNA2D2 0.591830122989234 0.0444780564859344 -4.04922734123758 1.12027274781151e-11 PITA;miRNATAP -0.2699294848883 0.00467301724446021 NA NA NA hsa-miR-590-3p CACNA2D2 0.83851360565783 0.00129224433453587 -4.04922734123758 1.12027274781151e-11 miRanda -0.910080316220079 5.50809508757429e-13 NA NA NA hsa-miR-96-5p CACNA2D2 3.0381097138467 4.40362891630201e-24 -4.04922734123758 1.12027274781151e-11 MirTarget;TargetScan;miRNATAP -0.460177451007506 6.52265029481551e-06 NA NA NA hsa-miR-421 CACNA2D3 0.170525317701774 0.535277026680289 -0.939772778084012 0.0122145158022468 miRanda -0.20521615629947 0.00273380878286458 NA NA NA hsa-miR-590-3p CACNA2D3 0.83851360565783 0.00129224433453587 -0.939772778084012 0.0122145158022468 miRanda -0.378634247044458 1.58606315364893e-06 NA NA NA hsa-miR-335-3p CACNA2D4 1.51116383169018 6.88553098788624e-13 -0.253817115518502 0.170080596958744 mirMAP -0.201336843540192 2.73676164579828e-07 NA NA NA hsa-miR-335-5p CACNA2D4 -0.466533891325811 0.0676987038122831 -0.253817115518502 0.170080596958744 miRNAWalker2_validate -0.103264520109086 0.00569004178609546 NA NA NA hsa-miR-429 CACNA2D4 2.3794516574089 1.72813419703734e-13 -0.253817115518502 0.170080596958744 miRanda -0.122394277669212 9.42744195649268e-06 NA NA NA hsa-miR-24-3p CACNB1 -0.0357874587555003 0.785865078836504 0.364049064896473 0.201219269660059 miRNATAP -0.35125126468815 0.000514883528135464 NA NA NA hsa-miR-320b CACNB1 0.226640952564488 0.378818692487242 0.364049064896473 0.201219269660059 miRanda -0.188816221711621 0.000206201473724571 NA NA NA hsa-miR-181b-5p CACNB2 0.668793269169928 0.000239998092406404 -0.604075256292693 0.0361720253148353 miRNATAP -0.216468217708711 0.00303646171866961 NA NA NA hsa-miR-182-5p CACNB2 3.21839823004635 5.13049145201115e-39 -0.604075256292693 0.0361720253148353 miRNATAP -0.219442557195728 8.33698439945931e-06 NA NA NA hsa-miR-29a-5p CACNB2 1.89519956688438 1.03453349363915e-11 -0.604075256292693 0.0361720253148353 MirTarget -0.151583066884848 0.00664807073767572 NA NA NA hsa-miR-96-5p CACNB2 3.0381097138467 4.40362891630201e-24 -0.604075256292693 0.0361720253148353 miRNATAP -0.180896986105902 0.000186284711882076 NA NA NA hsa-miR-140-3p CACNB3 -1.11373309124537 8.35257079443689e-14 0.911296235030083 1.2158842048257e-05 PITA;miRNATAP -0.327718619315256 2.07772599028282e-07 NA NA NA hsa-miR-150-5p CACNB3 -0.702328520623782 0.0215316651134431 0.911296235030083 1.2158842048257e-05 miRNATAP -0.156383470200707 5.93290759550019e-07 NA NA NA hsa-miR-342-5p CACNB3 -0.382174669348421 0.0896996965047193 0.911296235030083 1.2158842048257e-05 PITA -0.152003137556313 0.000403496499737485 NA NA NA hsa-let-7g-3p CACNB4 2.38336858943031 4.8771148585792e-17 -2.28842727443691 1.30647786946906e-11 miRNATAP -0.242547119318179 6.5305329279024e-06 NA NA NA hsa-miR-132-3p CACNB4 0.0122601212105202 0.934032846062939 -2.28842727443691 1.30647786946906e-11 miRNATAP -0.312478674159917 0.00417176648828546 NA NA NA hsa-miR-182-5p CACNB4 3.21839823004635 5.13049145201115e-39 -2.28842727443691 1.30647786946906e-11 miRNATAP -0.206550218597975 0.000493489971572607 NA NA NA hsa-miR-183-5p CACNB4 2.39247234736657 3.92444525331999e-21 -2.28842727443691 1.30647786946906e-11 miRNATAP -0.255437745274291 1.95262747203954e-05 NA NA NA hsa-miR-196b-5p CACNB4 1.85699053895181 0.000944585924552801 -2.28842727443691 1.30647786946906e-11 miRNATAP -0.112153125111729 6.50572859715669e-05 NA NA NA hsa-miR-20a-3p CACNB4 2.51803599558247 4.92479325298629e-13 -2.28842727443691 1.30647786946906e-11 miRNATAP -0.215474685878167 0.000174854362408923 NA NA NA hsa-miR-212-3p CACNB4 0.404496907089793 0.103551762277891 -2.28842727443691 1.30647786946906e-11 miRNATAP -0.346377074207987 4.92300443310257e-08 NA NA NA hsa-miR-222-3p CACNB4 0.0327210697409583 0.881937768109611 -2.28842727443691 1.30647786946906e-11 miRNATAP -0.210442381503527 0.00377623556851065 NA NA NA hsa-miR-29a-5p CACNB4 1.89519956688438 1.03453349363915e-11 -2.28842727443691 1.30647786946906e-11 mirMAP -0.272802961307661 4.23138509603761e-05 NA NA NA hsa-miR-29b-1-5p CACNB4 1.71024742617744 3.64915691793611e-09 -2.28842727443691 1.30647786946906e-11 mirMAP -0.255327568985584 1.93064667815686e-06 NA NA NA hsa-miR-335-3p CACNB4 1.51116383169018 6.88553098788624e-13 -2.28842727443691 1.30647786946906e-11 mirMAP -0.230695923442885 0.00182923253380827 NA NA NA hsa-miR-424-5p CACNB4 1.26485330287919 6.1498991028257e-06 -2.28842727443691 1.30647786946906e-11 miRNATAP -0.257275221423476 4.45892776855066e-06 NA NA NA hsa-miR-450b-5p CACNB4 1.69248953402469 1.96052058003353e-07 -2.28842727443691 1.30647786946906e-11 miRNATAP -0.22403479061782 3.12677891045234e-05 NA NA NA hsa-miR-542-3p CACNB4 1.62226640768239 2.6427102465476e-10 -2.28842727443691 1.30647786946906e-11 miRanda -0.201392287912568 0.000932693761693117 NA NA NA hsa-miR-589-3p CACNB4 1.34253876396688 1.84935927493927e-05 -2.28842727443691 1.30647786946906e-11 mirMAP -0.142058437706785 0.00636457160484992 NA NA NA hsa-miR-590-3p CACNB4 0.83851360565783 0.00129224433453587 -2.28842727443691 1.30647786946906e-11 miRanda;mirMAP;miRNATAP -0.29208187326899 6.13860847815289e-05 NA NA NA hsa-miR-708-3p CACNB4 3.43841959417743 4.40027692981683e-28 -2.28842727443691 1.30647786946906e-11 mirMAP -0.283412856382356 8.65432976662043e-08 NA NA NA hsa-miR-96-5p CACNB4 3.0381097138467 4.40362891630201e-24 -2.28842727443691 1.30647786946906e-11 TargetScan;miRNATAP -0.277362884028421 1.56851782241664e-06 NA NA NA hsa-miR-186-5p CACNG4 0.852175445703945 6.88885738584309e-10 -2.31771785561484 0.00022008101883695 mirMAP -0.589590505055022 0.00490208390442921 NA NA NA hsa-miR-29b-3p CACNG4 3.10527711861309 3.01242507282711e-32 -2.31771785561484 0.00022008101883695 miRNATAP -0.361264470736973 0.000450055693206786 NA NA NA hsa-miR-29c-3p CACNG4 1.32354490728858 1.84279305179762e-07 -2.31771785561484 0.00022008101883695 miRNATAP -0.296065493654257 0.00898604449774817 NA NA NA hsa-miR-375 CACNG4 0.615547997686534 0.149199273675144 -2.31771785561484 0.00022008101883695 miRanda -0.37450056860937 2.49278277942626e-08 NA NA NA hsa-miR-582-3p CACNG4 1.70881364237226 1.26508456000083e-06 -2.31771785561484 0.00022008101883695 miRNATAP -0.446220929185291 2.93964484395776e-08 NA NA NA hsa-miR-139-5p CASP3 -2.26625553116965 7.22375119369519e-16 0.749868979708077 8.30799302647668e-11 miRanda -0.103400450602475 1.92824413318983e-08 NA NA NA hsa-miR-195-3p CASP3 -1.33068822339418 6.65427393047357e-09 0.749868979708077 8.30799302647668e-11 MirTarget -0.12156615230384 1.38560895801409e-07 NA NA NA hsa-miR-30c-5p CASP3 -0.327319105755825 0.123595832152687 0.749868979708077 8.30799302647668e-11 miRNATAP -0.14954468041522 2.8553699558622e-09 NA NA NA hsa-miR-30d-5p CASP3 -0.920901858717441 3.50898334321668e-05 0.749868979708077 8.30799302647668e-11 miRNAWalker2_validate;miRTarBase;miRNATAP -0.173377620122409 2.06657661969359e-13 NA NA NA hsa-miR-335-5p CD14 -0.466533891325811 0.0676987038122831 -0.495520219302209 0.0437754619921581 miRNAWalker2_validate -0.152715745419673 0.00210430614140529 NA NA NA hsa-let-7a-5p CDC25B -1.37014061604018 3.11451492971224e-14 0.434458604444449 0.03249037912714 miRNAWalker2_validate -0.283049852145059 1.58468224550705e-08 NA NA NA hsa-miR-15a-5p CHUK 1.62575353599172 1.55312121019827e-19 0.0377297766878195 0.74424413982199 miRNAWalker2_validate;miRTarBase;MirTarget -0.156480048093973 2.55421092282135e-08 NA NA NA hsa-miR-29b-2-5p CHUK 0.345881055247341 0.194842633194187 0.0377297766878195 0.74424413982199 MirTarget -0.119533869512923 1.02102108327589e-09 NA NA NA hsa-miR-339-5p CHUK 0.536997313601114 0.0488090394176611 0.0377297766878195 0.74424413982199 miRanda -0.101676919866514 1.24374098863621e-07 NA NA NA hsa-miR-342-3p CHUK -0.128691966564961 0.561034080130801 0.0377297766878195 0.74424413982199 miRanda -0.176769532720248 4.41422217910121e-14 NA NA NA hsa-miR-497-5p CHUK -0.0546347378264729 0.786205564901684 0.0377297766878195 0.74424413982199 MirTarget -0.194599570543196 4.42801403790986e-14 NA NA NA hsa-miR-106a-5p CRK 1.3902608059488 6.07931522284525e-05 -0.690360111633399 9.32738747967062e-10 MirTarget;miRNATAP -0.113652176124985 5.90012366603754e-12 NA NA NA hsa-miR-142-3p CRK 3.98476449801341 1.56256182021111e-35 -0.690360111633399 9.32738747967062e-10 PITA;miRanda;miRNATAP -0.11723592063814 1.98285983955657e-15 NA NA NA hsa-miR-142-5p CRK 1.29672439149353 4.0768822158894e-06 -0.690360111633399 9.32738747967062e-10 PITA;mirMAP -0.100729749327611 4.40159518141072e-07 NA NA NA hsa-miR-146a-5p CRK 0.684701497250824 0.0105316554224149 -0.690360111633399 9.32738747967062e-10 MirTarget -0.134130528120247 1.17765225740691e-11 NA NA NA hsa-miR-146b-5p CRK 1.0922867893808 5.63754607494775e-06 -0.690360111633399 9.32738747967062e-10 MirTarget -0.146701554173863 5.49547770861136e-12 NA NA NA hsa-miR-17-5p CRK 2.07078488653279 2.77403038572568e-19 -0.690360111633399 9.32738747967062e-10 MirTarget;TargetScan;miRNATAP -0.102609724820135 2.55861755510564e-06 NA NA NA hsa-miR-186-5p CRK 0.852175445703945 6.88885738584309e-10 -0.690360111633399 9.32738747967062e-10 miRNATAP -0.139063103071695 0.000239670638585544 NA NA NA hsa-miR-20a-5p CRK 2.64649625616975 5.1469418982085e-27 -0.690360111633399 9.32738747967062e-10 MirTarget;miRNATAP -0.123923188532199 4.79809378358024e-10 NA NA NA hsa-miR-30c-5p CRK -0.327319105755825 0.123595832152687 -0.690360111633399 9.32738747967062e-10 miRNATAP -0.156095953940097 1.74902370358079e-10 NA NA NA hsa-miR-362-3p CRK 0.194097672030785 0.52808475179225 -0.690360111633399 9.32738747967062e-10 miRanda -0.133898476873089 2.14893713865778e-10 NA NA NA hsa-miR-374a-5p CRK -0.197027254874826 0.298080902192861 -0.690360111633399 9.32738747967062e-10 mirMAP -0.134718743069141 1.59952662743119e-05 NA NA NA hsa-miR-374b-5p CRK 0.474691035780475 0.0109217471394203 -0.690360111633399 9.32738747967062e-10 mirMAP -0.1303418115005 1.18828975951902e-05 NA NA NA hsa-miR-93-5p CRK 1.50844106515467 1.83836866996875e-12 -0.690360111633399 9.32738747967062e-10 MirTarget;miRNATAP -0.140137804632918 3.64876278396232e-09 NA NA NA hsa-miR-140-5p CRKL 0.669142684153918 0.000335928403032308 -0.165162533162818 0.151252347886535 MirTarget;miRanda -0.125766232472249 1.32956411484001e-05 NA NA NA hsa-miR-30b-5p CRKL 0.358144314839612 0.138026229059594 -0.165162533162818 0.151252347886535 MirTarget;mirMAP -0.124093253817077 9.38046717250416e-09 NA NA NA hsa-miR-30c-5p CRKL -0.327319105755825 0.123595832152687 -0.165162533162818 0.151252347886535 MirTarget;mirMAP;miRNATAP -0.110488373263447 8.13843128474289e-06 NA NA NA hsa-miR-497-5p CRKL -0.0546347378264729 0.786205564901684 -0.165162533162818 0.151252347886535 MirTarget;miRNATAP -0.140049554860128 7.74821392229802e-08 NA NA NA hsa-miR-141-3p DUSP1 3.36993755486106 5.42939251147195e-32 -2.07031932837713 1.01902983692044e-11 TargetScan -0.206737676824773 8.39674189048993e-06 NA NA NA hsa-miR-148a-3p DUSP1 2.30885799126944 1.95226081368985e-21 -2.07031932837713 1.01902983692044e-11 miRNATAP -0.170828809731551 0.00248877296954875 NA NA NA hsa-miR-200b-3p DUSP1 1.55157578247391 4.83790020897188e-09 -2.07031932837713 1.01902983692044e-11 MirTarget;TargetScan -0.17073103651151 0.00132940288920939 NA NA NA hsa-miR-22-5p DUSP1 1.71436244278242 9.85038001236064e-15 -2.07031932837713 1.01902983692044e-11 MirTarget;miRNATAP -0.173247489232781 0.00599863480720847 NA NA NA hsa-miR-324-3p DUSP1 -0.0774700133118458 0.689226297032231 -2.07031932837713 1.01902983692044e-11 MirTarget -0.210828628606814 0.00468305831190507 NA NA NA hsa-miR-331-5p DUSP1 0.578237334664505 0.00131211239210882 -2.07031932837713 1.01902983692044e-11 PITA;miRNATAP -0.345132268390074 2.35645472721618e-05 NA NA NA hsa-miR-425-3p DUSP1 0.253253025718618 0.16866885050911 -2.07031932837713 1.01902983692044e-11 MirTarget -0.342326880128107 1.14946348728655e-05 NA NA NA hsa-miR-429 DUSP1 2.3794516574089 1.72813419703734e-13 -2.07031932837713 1.01902983692044e-11 MirTarget;PITA;miRanda;miRNATAP -0.199561894275042 1.85903968005543e-05 NA NA NA hsa-miR-186-5p DUSP10 0.852175445703945 6.88885738584309e-10 0.407100540749769 0.0457719242717631 mirMAP -0.179361164391299 0.008039807014958 NA NA NA hsa-miR-92a-3p DUSP10 -0.136362762339122 0.493412263619364 0.407100540749769 0.0457719242717631 MirTarget;miRNATAP -0.173616572422467 0.000241559881029457 24332650 DUSP10 is responsible for miR-92a induced JNK signalling and cell proliferation pancreatic cancer hsa-miR-342-3p DUSP16 -0.128691966564961 0.561034080130801 -0.391681957554089 0.0115905458024696 miRNATAP -0.161564388733489 4.93814265918782e-07 NA NA NA hsa-miR-361-5p DUSP16 0.21454431962475 0.0800957579368424 -0.391681957554089 0.0115905458024696 miRanda -0.197709677576382 0.000866901140021963 NA NA NA hsa-miR-28-5p DUSP22 1.19639196514745 4.59365801666536e-18 -0.442031368617824 0.00014908332000764 miRanda -0.171721288756116 5.42993871261643e-06 NA NA NA hsa-miR-141-3p DUSP3 3.36993755486106 5.42939251147195e-32 -0.708804425610406 1.40313691817122e-11 MirTarget;TargetScan;miRNATAP -0.106013334758399 1.42985111385774e-11 NA NA NA hsa-miR-182-5p DUSP3 3.21839823004635 5.13049145201115e-39 -0.708804425610406 1.40313691817122e-11 mirMAP -0.12277081577911 8.1425413006432e-12 NA NA NA hsa-miR-186-5p DUSP3 0.852175445703945 6.88885738584309e-10 -0.708804425610406 1.40313691817122e-11 mirMAP -0.14132026135571 6.19908258377357e-05 NA NA NA hsa-miR-3913-5p DUSP3 0.717213610841846 0.00237248441853322 -0.708804425610406 1.40313691817122e-11 MirTarget -0.11258836303491 1.22721810611486e-05 NA NA NA hsa-let-7a-5p DUSP4 -1.37014061604018 3.11451492971224e-14 1.52626313798337 0.00013620805685873 TargetScan;miRNATAP -0.349036985343289 0.000501853098098253 NA NA NA hsa-miR-3065-5p DUSP4 0.653308707552535 0.0999497219778851 1.52626313798337 0.00013620805685873 mirMAP -0.179105224342141 0.000405051652282506 NA NA NA hsa-miR-30b-3p DUSP4 -1.20976737190106 2.63726511331003e-06 1.52626313798337 0.00013620805685873 MirTarget -0.221443707717627 0.00192529206803887 NA NA NA hsa-miR-450b-5p DUSP4 1.69248953402469 1.96052058003353e-07 1.52626313798337 0.00013620805685873 mirMAP -0.279178013115786 8.04676225079362e-06 NA NA NA hsa-miR-452-5p DUSP4 0.637123950346362 0.0458173998136196 1.52626313798337 0.00013620805685873 mirMAP -0.485589679557177 4.60471202843568e-18 NA NA NA hsa-miR-129-5p DUSP6 -0.405735314747643 0.341485636033577 -0.562669938464236 0.042518684388822 miRanda -0.132640462950009 9.29464289368602e-06 NA NA NA hsa-miR-186-5p DUSP6 0.852175445703945 6.88885738584309e-10 -0.562669938464236 0.042518684388822 mirMAP -0.522486161540383 9.08750736894747e-09 NA NA NA hsa-miR-342-3p DUSP6 -0.128691966564961 0.561034080130801 -0.562669938464236 0.042518684388822 PITA;miRanda -0.164781669030781 0.00450219882743952 NA NA NA hsa-miR-374a-5p DUSP6 -0.197027254874826 0.298080902192861 -0.562669938464236 0.042518684388822 mirMAP -0.230408052595457 0.00247935615595755 NA NA NA hsa-miR-590-3p DUSP6 0.83851360565783 0.00129224433453587 -0.562669938464236 0.042518684388822 PITA;miRanda;mirMAP -0.279204769429728 1.64662175437224e-06 NA NA NA hsa-miR-107 DUSP7 0.658676029898313 5.11480446318819e-07 -0.458943984731187 0.00582684364658649 miRanda -0.193345155080251 0.000985449694430155 NA NA NA hsa-miR-10a-5p DUSP7 0.790595816051606 0.000593731378445468 -0.458943984731187 0.00582684364658649 mirMAP -0.137304152975954 3.35246338954039e-05 NA NA NA hsa-miR-141-3p DUSP7 3.36993755486106 5.42939251147195e-32 -0.458943984731187 0.00582684364658649 TargetScan -0.136050816692744 3.58240991588387e-08 NA NA NA hsa-miR-186-5p DUSP7 0.852175445703945 6.88885738584309e-10 -0.458943984731187 0.00582684364658649 mirMAP -0.234331473298733 2.0405286532395e-05 NA NA NA hsa-miR-421 DUSP7 0.170525317701774 0.535277026680289 -0.458943984731187 0.00582684364658649 mirMAP -0.135395709893835 7.25437592853974e-06 NA NA NA hsa-miR-590-3p DUSP7 0.83851360565783 0.00129224433453587 -0.458943984731187 0.00582684364658649 miRanda -0.11782512138794 0.000812428776068211 NA NA NA hsa-miR-106b-5p DUSP8 1.47447672652218 1.32004094930462e-13 -0.989196545334459 1.08880812519481e-05 MirTarget;miRNATAP -0.134286874004918 0.00884696995328531 NA NA NA hsa-miR-130b-3p DUSP8 1.83046548750752 5.04753914574694e-13 -0.989196545334459 1.08880812519481e-05 miRNAWalker2_validate -0.126157740363126 0.002918505139109 NA NA NA hsa-miR-21-5p DUSP8 4.38165933891779 1.52536633902505e-92 -0.989196545334459 1.08880812519481e-05 miRNAWalker2_validate;MirTarget -0.125579189054671 0.00156667289625618 NA NA NA hsa-miR-378c DUSP8 -1.1528833105561 7.25986666044199e-07 -0.989196545334459 1.08880812519481e-05 miRNATAP -0.154519625061776 0.000512389005915382 NA NA NA hsa-miR-582-3p DUSP8 1.70881364237226 1.26508456000083e-06 -0.989196545334459 1.08880812519481e-05 mirMAP -0.136814602615968 2.45262654540878e-06 NA NA NA hsa-miR-625-5p DUSP8 1.38208523187596 6.28473801440755e-07 -0.989196545334459 1.08880812519481e-05 MirTarget -0.111348560979422 0.00756260036466474 NA NA NA hsa-let-7a-5p DUSP9 -1.37014061604018 3.11451492971224e-14 3.29795316192754 7.87940825565651e-08 TargetScan;miRNATAP -0.570758631618804 0.00023253924361693 NA NA NA hsa-let-7b-5p DUSP9 -1.62016148171663 1.56547487335694e-15 3.29795316192754 7.87940825565651e-08 miRNATAP -0.478445555820282 0.000480646947116406 NA NA NA hsa-miR-194-5p DUSP9 1.76979641760284 8.2064222072696e-05 3.29795316192754 7.87940825565651e-08 MirTarget;miRNATAP -0.224156635451834 0.000384548218695216 NA NA NA hsa-miR-30a-3p DUSP9 -2.54042202792785 2.9111625410859e-18 3.29795316192754 7.87940825565651e-08 MirTarget -0.401107546782219 2.07821571009008e-05 NA NA NA hsa-miR-338-3p DUSP9 0.726843067232002 0.0506251324215494 3.29795316192754 7.87940825565651e-08 mirMAP -0.25087860151406 0.00110687991138874 NA NA NA hsa-miR-361-3p DUSP9 0.0988926195529967 0.549128728500555 3.29795316192754 7.87940825565651e-08 mirMAP -0.497917445950562 0.00458942911019824 NA NA NA hsa-miR-141-3p EGFR 3.36993755486106 5.42939251147195e-32 -0.271157231776117 0.423394925561077 MirTarget -0.182043268046231 0.000322561477910029 26025929 Treatment with the EGFR inhibitor AG1478 or overexpression of miR141 blocked the activity of ERK downstream of EGFR and inhibited KLF8-depndent cell invasiveness proliferation and viability in cell culture and invasive growth and lung metastasis in nude mice metastasis breast cancer hsa-miR-142-3p EGFR 3.98476449801341 1.56256182021111e-35 -0.271157231776117 0.423394925561077 miRanda -0.13728647251485 0.00224315827652832 NA NA NA hsa-miR-148b-5p EGFR 1.39335695292409 2.13220380550073e-07 -0.271157231776117 0.423394925561077 mirMAP -0.312208825866794 5.03093953543843e-06 NA NA NA hsa-miR-17-5p EGFR 2.07078488653279 2.77403038572568e-19 -0.271157231776117 0.423394925561077 TargetScan -0.227660150278677 0.000449250209613956 NA NA NA hsa-miR-192-5p EGFR 2.03412119423736 1.6357945826287e-05 -0.271157231776117 0.423394925561077 mirMAP -0.148537455733138 4.68324614985853e-06 NA NA NA hsa-miR-19b-1-5p EGFR 1.71217036351784 3.28561659177495e-12 -0.271157231776117 0.423394925561077 MirTarget;mirMAP -0.196763487131799 0.00607880458029935 NA NA NA hsa-miR-200a-3p EGFR 3.14766878548496 1.32850889777422e-21 -0.271157231776117 0.423394925561077 MirTarget -0.135522178803702 0.00339714885174827 26184032;19671845 MicroRNA 200a Targets EGFR and c Met to Inhibit Migration Invasion and Gefitinib Resistance in Non Small Cell Lung Cancer; In this study we found that miR-200a is downregulated in NSCLC cells where it directly targets the 3'-UTR of both EGFR and c-Met mRNA; Overexpression of miR-200a in NSCLC cells significantly downregulates both EGFR and c-Met levels and severely inhibits cell migration and invasion;Protein expression and signaling pathway modulation as well as intracellular distribution of EGFR and ERRFI-1 were validated through Western blot analysis and confocal microscopy whereas ERRFI-1 direct target of miR-200 members was validated by using the wild-type and mutant 3'-untranslated region/ERRFI-1/luciferse reporters; We identified a tight association between the expression of miRNAs of the miR-200 family epithelial phenotype and sensitivity to EGFR inhibitors-induced growth inhibition in bladder carcinoma cell lines; The changes in EGFR sensitivity by silencing or forced expression of ERRFI-1 or by miR-200 expression have also been validated in additional cell lines UMUC5 and T24; Members of the miR-200 family appear to control the EMT process and sensitivity to EGFR therapy in bladder cancer cells and the expression of miR-200 is sufficient to restore EGFR dependency at least in some of the mesenchymal bladder cancer cells drug resistance;cell migration; lung squamous cell cancer;bladder cancer hsa-miR-320b EGFR 0.226640952564488 0.378818692487242 -0.271157231776117 0.423394925561077 miRanda;mirMAP -0.169207384217798 0.00529161513582327 NA NA NA hsa-miR-335-5p EGFR -0.466533891325811 0.0676987038122831 -0.271157231776117 0.423394925561077 miRNAWalker2_validate -0.183988914461652 0.00717835650953039 NA NA NA hsa-miR-375 EGFR 0.615547997686534 0.149199273675144 -0.271157231776117 0.423394925561077 miRanda -0.181944225035217 4.73664955454239e-07 NA NA NA hsa-miR-145-5p ELK4 -1.34926078156437 2.63526538800669e-07 0.429221479035573 0.00233855368048961 miRNATAP -0.112437534764265 3.87867521194895e-06 NA NA NA hsa-miR-26b-5p ELK4 0.72362441215247 4.7794659748036e-05 0.429221479035573 0.00233855368048961 mirMAP -0.103034102886751 0.00479148461560788 NA NA NA hsa-miR-30c-5p ELK4 -0.327319105755825 0.123595832152687 0.429221479035573 0.00233855368048961 mirMAP -0.141056551426399 3.72776750480271e-06 NA NA NA hsa-miR-342-3p ELK4 -0.128691966564961 0.561034080130801 0.429221479035573 0.00233855368048961 mirMAP -0.132567675901113 6.07967248415551e-06 NA NA NA hsa-miR-106a-5p FAS 1.3902608059488 6.07931522284525e-05 -0.878746828084236 0.000340153420442741 miRNAWalker2_validate;miRTarBase -0.274948885695996 7.27787651364869e-15 22431000;27142596 miR 106a is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS; Bioinformatic analysis combining with validation experiments identified FAS as a direct target of miR-106a; Moreover a significant inverse correlation was found between miR-106a and FAS expression not only in gastric cancer cell lines but also in gastric cancer specimens; Taken together these findings suggest that ectopicly overexpressed miR-106a may play an oncogenic role in gastric carcinogenesis and impair extrinsic apoptotic pathway through targeting FAS;Functional experiment ascertained that miR-106a interacted with FAS and mediated caspase3 pathway tumorigenesis; gastric cancer;gastric cancer hsa-miR-590-5p FAS 2.07441240363458 4.95240551694843e-14 -0.878746828084236 0.000340153420442741 miRanda -0.282578087201106 9.10535063456113e-09 NA NA NA hsa-let-7e-5p FASLG -0.749418249305995 7.34668338492227e-05 0.227219484524508 0.525243087995098 miRNATAP -0.243056494896728 0.00520293662614488 NA NA NA hsa-miR-16-1-3p FGF1 1.50034693398929 6.63958242991125e-10 -0.577676136313124 0.0506048044371249 mirMAP -0.264990724395016 0.000104336880288483 NA NA NA hsa-miR-186-5p FGF1 0.852175445703945 6.88885738584309e-10 -0.577676136313124 0.0506048044371249 mirMAP -0.468236590634635 1.51395461317672e-06 NA NA NA hsa-miR-18a-5p FGF1 1.37435209536521 9.2173853686829e-06 -0.577676136313124 0.0506048044371249 MirTarget -0.313741396264592 1.24482978490312e-11 NA NA NA hsa-miR-320b FGF1 0.226640952564488 0.378818692487242 -0.577676136313124 0.0506048044371249 miRanda -0.145122007313635 0.00620299731128628 NA NA NA hsa-miR-330-5p FGF1 0.168520831101569 0.336433937906706 -0.577676136313124 0.0506048044371249 miRanda;miRNATAP -0.396337147508732 3.26538084155222e-07 NA NA NA hsa-miR-429 FGF1 2.3794516574089 1.72813419703734e-13 -0.577676136313124 0.0506048044371249 miRNATAP -0.116223459446297 0.00906049231323183 NA NA NA hsa-miR-576-5p FGF1 1.02693643167056 1.14846964470173e-06 -0.577676136313124 0.0506048044371249 PITA;mirMAP -0.353451864713746 2.30476528411685e-08 NA NA NA hsa-miR-590-5p FGF1 2.07441240363458 4.95240551694843e-14 -0.577676136313124 0.0506048044371249 MirTarget;miRanda;miRNATAP -0.188750550916759 0.00157081419432906 NA NA NA hsa-miR-629-5p FGF1 1.31657090341737 1.45711558652127e-12 -0.577676136313124 0.0506048044371249 MirTarget -0.255543406785593 0.000362449168272974 NA NA NA hsa-miR-7-5p FGF1 0.343825848926135 0.435063427976906 -0.577676136313124 0.0506048044371249 miRNAWalker2_validate -0.167943341210869 1.20539892015732e-05 NA NA NA hsa-let-7a-5p FGF11 -1.37014061604018 3.11451492971224e-14 3.58238481677861 7.07821884742881e-23 TargetScan;mirMAP;miRNATAP -0.568985035003898 1.41653445623786e-09 NA NA NA hsa-let-7b-5p FGF11 -1.62016148171663 1.56547487335694e-15 3.58238481677861 7.07821884742881e-23 mirMAP;miRNATAP -0.480829455651022 7.33790550378727e-09 NA NA NA hsa-let-7d-5p FGF11 -0.618145137285851 6.06067642715858e-05 3.58238481677861 7.07821884742881e-23 mirMAP;miRNATAP -0.403117661585255 0.000426361486333792 NA NA NA hsa-miR-125a-5p FGF11 -1.04824536696301 3.97386082850476e-07 3.58238481677861 7.07821884742881e-23 mirMAP -0.283106012258554 0.000790298136640464 NA NA NA hsa-miR-195-5p FGF11 -1.01577502605386 4.80814718341729e-05 3.58238481677861 7.07821884742881e-23 mirMAP -0.276250424568979 0.000176750217569729 NA NA NA hsa-miR-221-5p FGF11 -2.2173523967387 1.8954728277084e-09 3.58238481677861 7.07821884742881e-23 miRNATAP -0.140867639708279 0.00355614353073565 NA NA NA hsa-miR-320a FGF11 -0.961144925954715 1.62478794429204e-08 3.58238481677861 7.07821884742881e-23 miRanda -0.314554800922091 0.00217972507442822 NA NA NA hsa-miR-335-5p FGF11 -0.466533891325811 0.0676987038122831 3.58238481677861 7.07821884742881e-23 miRNAWalker2_validate;mirMAP -0.256647530759583 0.000881158505615166 NA NA NA hsa-let-7b-3p FGF12 -1.81889978084306 6.9913416210266e-19 -0.540341291347842 0.2437250465075 MirTarget -0.28093879604846 0.0051773171700438 NA NA NA hsa-miR-200b-3p FGF12 1.55157578247391 4.83790020897188e-09 -0.540341291347842 0.2437250465075 TargetScan -0.237021249202824 0.00277049015484138 NA NA NA hsa-miR-29a-5p FGF12 1.89519956688438 1.03453349363915e-11 -0.540341291347842 0.2437250465075 MirTarget -0.276278524444419 0.00204171562114313 NA NA NA hsa-miR-3065-5p FGF12 0.653308707552535 0.0999497219778851 -0.540341291347842 0.2437250465075 mirMAP -0.219717935817458 0.000160441200217862 NA NA NA hsa-miR-429 FGF12 2.3794516574089 1.72813419703734e-13 -0.540341291347842 0.2437250465075 miRNATAP -0.210520637292102 0.0025270091646609 NA NA NA hsa-miR-455-5p FGF12 1.36946341828134 5.05118627562807e-08 -0.540341291347842 0.2437250465075 miRanda -0.291759936628716 0.0026130555582076 NA NA NA hsa-miR-511-5p FGF12 -0.299232651841262 0.292871281649728 -0.540341291347842 0.2437250465075 MirTarget -0.342048393598124 4.53535066794083e-06 NA NA NA hsa-miR-141-3p FGF13 3.36993755486106 5.42939251147195e-32 0.0874395647550581 0.810556248943047 TargetScan -0.199819863219093 0.000244921517068874 NA NA NA hsa-miR-338-5p FGF13 -1.83316380675941 4.03269924759167e-07 0.0874395647550581 0.810556248943047 PITA -0.175986648309995 0.000113756652771771 NA NA NA hsa-miR-421 FGF14 0.170525317701774 0.535277026680289 -1.420755529251 1.88430020060794e-06 miRanda -0.341718556233856 2.50791289827731e-10 NA NA NA hsa-miR-590-3p FGF14 0.83851360565783 0.00129224433453587 -1.420755529251 1.88430020060794e-06 miRanda -0.434093352571676 3.47983378758532e-12 NA NA NA hsa-miR-96-5p FGF14 3.0381097138467 4.40362891630201e-24 -1.420755529251 1.88430020060794e-06 TargetScan -0.342893565188291 4.97164511915916e-12 NA NA NA hsa-miR-21-5p FGF18 4.38165933891779 1.52536633902505e-92 -2.01878202132787 1.47991026443687e-06 miRNATAP -0.445995016466712 1.11879820670501e-09 NA NA NA hsa-miR-424-5p FGF18 1.26485330287919 6.1498991028257e-06 -2.01878202132787 1.47991026443687e-06 miRNATAP -0.208512227284213 0.00257215272427139 NA NA NA hsa-miR-590-5p FGF18 2.07441240363458 4.95240551694843e-14 -2.01878202132787 1.47991026443687e-06 miRanda;miRNATAP -0.29033796179898 0.000691235501435991 NA NA NA hsa-miR-9-5p FGF18 4.99250901331516 2.59132733422801e-19 -2.01878202132787 1.47991026443687e-06 miRNATAP -0.161460646965575 1.31749803347013e-06 NA NA NA hsa-miR-142-3p FGF2 3.98476449801341 1.56256182021111e-35 -2.54526710952658 2.81433930536102e-18 miRanda -0.108425653539561 0.00717069701654876 NA NA NA hsa-miR-15a-5p FGF2 1.62575353599172 1.55312121019827e-19 -2.54526710952658 2.81433930536102e-18 MirTarget;miRNATAP -0.36038112870066 1.28425682158144e-06 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-1-3p FGF2 1.50034693398929 6.63958242991125e-10 -2.54526710952658 2.81433930536102e-18 mirMAP -0.257821575620002 0.000236815470978822 NA NA NA hsa-miR-181b-5p FGF2 0.668793269169928 0.000239998092406404 -2.54526710952658 2.81433930536102e-18 mirMAP -0.262170032088161 0.000626951093969658 NA NA NA hsa-miR-186-5p FGF2 0.852175445703945 6.88885738584309e-10 -2.54526710952658 2.81433930536102e-18 miRNAWalker2_validate;mirMAP -0.312620722879404 0.00189105104228049 NA NA NA hsa-miR-19b-1-5p FGF2 1.71217036351784 3.28561659177495e-12 -2.54526710952658 2.81433930536102e-18 mirMAP -0.32669324350081 2.87433739267694e-07 NA NA NA hsa-miR-200b-3p FGF2 1.55157578247391 4.83790020897188e-09 -2.54526710952658 2.81433930536102e-18 mirMAP -0.237329951619637 4.11083003299206e-06 NA NA NA hsa-miR-200c-3p FGF2 0.380533388300368 0.0842181838538353 -2.54526710952658 2.81433930536102e-18 mirMAP -0.303839594432928 1.47159143745806e-06 NA NA NA hsa-miR-20a-3p FGF2 2.51803599558247 4.92479325298629e-13 -2.54526710952658 2.81433930536102e-18 mirMAP -0.234318235832673 2.96971224443726e-06 NA NA NA hsa-miR-21-3p FGF2 2.54206008030157 1.11598785398763e-30 -2.54526710952658 2.81433930536102e-18 mirMAP -0.372000947223037 1.77917903992197e-10 NA NA NA hsa-miR-21-5p FGF2 4.38165933891779 1.52536633902505e-92 -2.54526710952658 2.81433930536102e-18 mirMAP -0.439558209079983 1.20994163416464e-17 NA NA NA hsa-miR-29a-5p FGF2 1.89519956688438 1.03453349363915e-11 -2.54526710952658 2.81433930536102e-18 mirMAP -0.365049356850144 2.5272073429353e-10 NA NA NA hsa-miR-32-5p FGF2 0.876853679269853 6.04859399018691e-05 -2.54526710952658 2.81433930536102e-18 miRNAWalker2_validate -0.179124683112376 0.00965081572899845 NA NA NA hsa-miR-335-3p FGF2 1.51116383169018 6.88553098788624e-13 -2.54526710952658 2.81433930536102e-18 mirMAP -0.374424532101383 5.108451362917e-09 NA NA NA hsa-miR-429 FGF2 2.3794516574089 1.72813419703734e-13 -2.54526710952658 2.81433930536102e-18 mirMAP -0.274666460864277 1.00411224771278e-09 NA NA NA hsa-miR-450b-5p FGF2 1.69248953402469 1.96052058003353e-07 -2.54526710952658 2.81433930536102e-18 mirMAP -0.165505837504251 0.000468241696245016 NA NA NA hsa-miR-503-5p FGF2 1.97129438815516 2.1704434283035e-09 -2.54526710952658 2.81433930536102e-18 miRNAWalker2_validate -0.205012336037686 7.26622582895517e-07 NA NA NA hsa-miR-589-3p FGF2 1.34253876396688 1.84935927493927e-05 -2.54526710952658 2.81433930536102e-18 mirMAP -0.178139639483111 8.93094177354748e-05 NA NA NA hsa-miR-590-5p FGF2 2.07441240363458 4.95240551694843e-14 -2.54526710952658 2.81433930536102e-18 miRanda;mirMAP -0.34395539570476 1.33985562743507e-08 NA NA NA hsa-miR-93-3p FGF2 1.07631808403007 1.63747525692813e-05 -2.54526710952658 2.81433930536102e-18 mirMAP -0.263196364039628 1.81238194047644e-06 NA NA NA hsa-miR-3065-5p FGF5 0.653308707552535 0.0999497219778851 1.41965936869673 0.00663601545902237 mirMAP -0.30851318309695 2.58273355476571e-06 NA NA NA hsa-miR-30a-5p FGF5 -0.924084264430689 0.000762030454634728 1.41965936869673 0.00663601545902237 mirMAP -0.458682122515636 1.23681430790792e-07 NA NA NA hsa-miR-30b-5p FGF5 0.358144314839612 0.138026229059594 1.41965936869673 0.00663601545902237 mirMAP -0.539045077966163 5.42071635746139e-08 NA NA NA hsa-miR-30c-5p FGF5 -0.327319105755825 0.123595832152687 1.41965936869673 0.00663601545902237 mirMAP -0.720160664714379 1.3358272407005e-10 NA NA NA hsa-miR-30d-5p FGF5 -0.920901858717441 3.50898334321668e-05 1.41965936869673 0.00663601545902237 mirMAP -0.922796453852226 7.74508150171104e-19 NA NA NA hsa-miR-30e-5p FGF5 1.60414100786743 3.78951090573667e-19 1.41965936869673 0.00663601545902237 mirMAP -0.42672903139199 0.00102753035462209 NA NA NA hsa-miR-338-3p FGF5 0.726843067232002 0.0506251324215494 1.41965936869673 0.00663601545902237 miRanda -0.249982640438075 0.000108939596018716 NA NA NA hsa-miR-486-5p FGF5 -4.38592782786845 2.75864166493846e-29 1.41965936869673 0.00663601545902237 miRanda -0.172915883890662 0.0028302765942552 NA NA NA hsa-miR-500a-5p FGF5 0.648155655714409 0.0104657432932038 1.41965936869673 0.00663601545902237 mirMAP -0.391631377809049 5.96983250124773e-05 NA NA NA hsa-miR-501-5p FGF5 0.411357595674671 0.10435288464149 1.41965936869673 0.00663601545902237 PITA;mirMAP -0.425344723856289 7.43244452614636e-06 NA NA NA hsa-miR-107 FGF7 0.658676029898313 5.11480446318819e-07 -1.35096332880614 7.44222727225117e-07 PITA;miRanda;miRNATAP -0.384064720888837 7.51486049064498e-05 NA NA NA hsa-miR-15a-5p FGF7 1.62575353599172 1.55312121019827e-19 -1.35096332880614 7.44222727225117e-07 miRTarBase;miRNATAP -0.466793239192838 2.83453139790815e-12 NA NA NA hsa-miR-15b-5p FGF7 -1.25935038177398 1.83460220856901e-12 -1.35096332880614 7.44222727225117e-07 miRNATAP -0.195108702684649 0.00524641292904446 NA NA NA hsa-miR-16-1-3p FGF7 1.50034693398929 6.63958242991125e-10 -1.35096332880614 7.44222727225117e-07 mirMAP -0.415291526592944 3.77942867633909e-11 NA NA NA hsa-miR-16-2-3p FGF7 0.503964803530872 0.0263648405197492 -1.35096332880614 7.44222727225117e-07 mirMAP -0.32685238601193 5.84459614417273e-08 NA NA NA hsa-miR-16-5p FGF7 0.749619098384047 4.11649450706988e-06 -1.35096332880614 7.44222727225117e-07 miRNATAP -0.360407939054601 3.33302283380507e-06 NA NA NA hsa-miR-20a-5p FGF7 2.64649625616975 5.1469418982085e-27 -1.35096332880614 7.44222727225117e-07 miRNAWalker2_validate -0.394356736375477 7.25466480479139e-17 NA NA NA hsa-miR-421 FGF7 0.170525317701774 0.535277026680289 -1.35096332880614 7.44222727225117e-07 miRanda -0.163761788143437 0.00112347767405943 NA NA NA hsa-miR-429 FGF7 2.3794516574089 1.72813419703734e-13 -1.35096332880614 7.44222727225117e-07 miRNATAP -0.236095541262009 8.5203274937411e-09 NA NA NA hsa-miR-501-5p FGF7 0.411357595674671 0.10435288464149 -1.35096332880614 7.44222727225117e-07 PITA;mirMAP -0.240038572692252 1.49297440376449e-06 NA NA NA hsa-miR-590-3p FGF7 0.83851360565783 0.00129224433453587 -1.35096332880614 7.44222727225117e-07 PITA;miRanda;mirMAP;miRNATAP -0.153768635331909 0.00851407916887242 NA NA NA hsa-miR-590-5p FGF7 2.07441240363458 4.95240551694843e-14 -1.35096332880614 7.44222727225117e-07 PITA;miRanda -0.342399846177336 4.47018629152173e-10 NA NA NA hsa-miR-7-1-3p FGF7 2.61364240402652 1.98959237815786e-32 -1.35096332880614 7.44222727225117e-07 mirMAP -0.317243751289801 1.53104453627605e-08 NA NA NA hsa-miR-142-3p FGF9 3.98476449801341 1.56256182021111e-35 -1.33489997634345 0.0119359510527769 miRanda -0.297024649065488 2.41524362922675e-05 NA NA NA hsa-miR-142-5p FGF9 1.29672439149353 4.0768822158894e-06 -1.33489997634345 0.0119359510527769 mirMAP -0.338742204386594 0.000287338979970239 NA NA NA hsa-miR-16-2-3p FGF9 0.503964803530872 0.0263648405197492 -1.33489997634345 0.0119359510527769 mirMAP -0.43168768681555 0.000229313476417954 NA NA NA hsa-miR-16-5p FGF9 0.749619098384047 4.11649450706988e-06 -1.33489997634345 0.0119359510527769 miRNATAP -0.466038608257105 0.00194558955642264 NA NA NA hsa-miR-212-3p FGF9 0.404496907089793 0.103551762277891 -1.33489997634345 0.0119359510527769 mirMAP -0.264431225714465 0.00749196276633432 NA NA NA hsa-miR-424-5p FGF9 1.26485330287919 6.1498991028257e-06 -1.33489997634345 0.0119359510527769 miRNATAP -0.299762934200373 0.000543050338372439 NA NA NA hsa-miR-450b-5p FGF9 1.69248953402469 1.96052058003353e-07 -1.33489997634345 0.0119359510527769 mirMAP;miRNATAP -0.215374190152256 0.00967241936107216 NA NA NA hsa-miR-590-3p FGF9 0.83851360565783 0.00129224433453587 -1.33489997634345 0.0119359510527769 miRanda;mirMAP -0.548375938999422 9.0306963195563e-07 NA NA NA hsa-miR-590-5p FGF9 2.07441240363458 4.95240551694843e-14 -1.33489997634345 0.0119359510527769 miRanda -0.525972441590085 8.17616961503178e-07 NA NA NA hsa-miR-9-5p FGF9 4.99250901331516 2.59132733422801e-19 -1.33489997634345 0.0119359510527769 miRNATAP -0.15314002899298 0.000277214145018446 NA NA NA hsa-miR-135b-5p FGFR1 3.25019233805845 1.95560099639034e-15 -0.915442355826397 0.000285266909471616 mirMAP -0.141958622178533 1.77794898106879e-06 NA NA NA hsa-miR-15a-5p FGFR1 1.62575353599172 1.55312121019827e-19 -0.915442355826397 0.000285266909471616 miRNATAP -0.243009183557465 0.000100813439112054 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-5p FGFR1 0.749619098384047 4.11649450706988e-06 -0.915442355826397 0.000285266909471616 miRTarBase;miRNATAP -0.246942745271025 0.000561455743835118 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-17-5p FGFR1 2.07078488653279 2.77403038572568e-19 -0.915442355826397 0.000285266909471616 mirMAP -0.159812129963503 0.00102342937863635 NA NA NA hsa-miR-181b-5p FGFR1 0.668793269169928 0.000239998092406404 -0.915442355826397 0.000285266909471616 miRNAWalker2_validate -0.349477340528312 3.64168342971559e-08 NA NA NA hsa-miR-200a-5p FGFR1 2.26680634475411 1.52168554660094e-17 -0.915442355826397 0.000285266909471616 mirMAP -0.200300874512705 1.91408016005907e-06 NA NA NA hsa-miR-200b-5p FGFR1 0.5652412449293 0.0273948420835934 -0.915442355826397 0.000285266909471616 mirMAP -0.138058985825778 0.00247827404178829 NA NA NA hsa-miR-20a-5p FGFR1 2.64649625616975 5.1469418982085e-27 -0.915442355826397 0.000285266909471616 mirMAP -0.173284530375537 0.000105694699814125 NA NA NA hsa-miR-335-3p FGFR1 1.51116383169018 6.88553098788624e-13 -0.915442355826397 0.000285266909471616 mirMAP -0.240186682957272 8.57963673654244e-06 NA NA NA hsa-miR-146b-5p FGFR2 1.0922867893808 5.63754607494775e-06 -2.39472329620768 3.80959748314848e-11 miRanda -0.184601550928346 0.00873114443578221 NA NA NA hsa-miR-19b-1-5p FGFR2 1.71217036351784 3.28561659177495e-12 -2.39472329620768 3.80959748314848e-11 miRNAWalker2_validate;miRTarBase -0.268412662161793 0.000607501041413817 NA NA NA hsa-miR-542-3p FGFR2 1.62226640768239 2.6427102465476e-10 -2.39472329620768 3.80959748314848e-11 miRanda -0.190402208837821 0.00349409803579517 NA NA NA hsa-miR-590-3p FGFR2 0.83851360565783 0.00129224433453587 -2.39472329620768 3.80959748314848e-11 miRanda -0.383675956139752 7.77181884190165e-07 NA NA NA hsa-miR-142-3p FGFR3 3.98476449801341 1.56256182021111e-35 -1.12699077326621 0.0142487904494546 miRanda -0.224351946350102 0.000237439121756567 NA NA NA hsa-miR-16-5p FLNA 0.749619098384047 4.11649450706988e-06 -0.924583916672365 4.56435160750428e-05 miRNAWalker2_validate -0.290737189049525 5.84415867008081e-06 NA NA NA hsa-miR-200c-3p FLNA 0.380533388300368 0.0842181838538353 -0.924583916672365 4.56435160750428e-05 miRNAWalker2_validate -0.368304922971275 2.39863918444007e-15 NA NA NA hsa-miR-20a-5p FLNA 2.64649625616975 5.1469418982085e-27 -0.924583916672365 4.56435160750428e-05 miRNAWalker2_validate -0.22239157206061 2.48581666303275e-08 NA NA NA hsa-miR-324-5p FLNA 1.06955541886548 5.39722006604758e-05 -0.924583916672365 4.56435160750428e-05 miRNAWalker2_validate -0.199810957862419 3.17589781396671e-07 NA NA NA hsa-miR-7-5p FLNA 0.343825848926135 0.435063427976906 -0.924583916672365 4.56435160750428e-05 miRNAWalker2_validate -0.118496023454617 6.5588409173022e-05 NA NA NA hsa-miR-92a-3p FLNA -0.136362762339122 0.493412263619364 -0.924583916672365 4.56435160750428e-05 miRNAWalker2_validate -0.140320017317704 0.00832845787321449 NA NA NA hsa-miR-92b-3p FLNA 0.0478787637665503 0.831716894621477 -0.924583916672365 4.56435160750428e-05 miRNAWalker2_validate -0.136897577313915 0.00349430142338408 NA NA NA hsa-miR-454-3p FLNC 1.49453641052169 4.46235742871434e-09 -1.30543686289122 0.00221560919474228 miRNAWalker2_validate -0.279129622877489 0.0022228169472534 NA NA NA hsa-miR-155-5p FOS 0.813513839059142 0.000608282725633232 -1.92872707680398 6.31413417330173e-09 MirTarget -0.18347634311678 0.0050017108500929 23693020 Also S100P treatment stimulated the enrichment of c-Fos an AP-1 family member at the miR-155 host gene promoter site colon cancer hsa-miR-199a-3p FOS 1.67715607711377 5.96963028176444e-15 -1.92872707680398 6.31413417330173e-09 MirTarget;PITA -0.229976371579782 0.00107430382942602 NA NA NA hsa-miR-199b-3p FOS 1.67802185853505 6.03525898173555e-15 -1.92872707680398 6.31413417330173e-09 MirTarget;PITA;miRNATAP -0.230322004727313 0.00104703927561188 NA NA NA hsa-miR-28-3p FOS 0.387144500601444 0.00777919765254534 -1.92872707680398 6.31413417330173e-09 MirTarget;PITA;miRNATAP -0.303537440249226 0.00496541623945134 NA NA NA hsa-miR-335-3p FOS 1.51116383169018 6.88553098788624e-13 -1.92872707680398 6.31413417330173e-09 MirTarget -0.276602039240365 0.000123215460363428 NA NA NA hsa-miR-424-3p FOS 0.329674131594021 0.245794308921274 -1.92872707680398 6.31413417330173e-09 MirTarget;miRNATAP -0.207302663781988 0.00016082681173383 NA NA NA hsa-miR-589-3p FOS 1.34253876396688 1.84935927493927e-05 -1.92872707680398 6.31413417330173e-09 MirTarget -0.1920121256013 0.000148751942980904 NA NA NA hsa-miR-590-3p FOS 0.83851360565783 0.00129224433453587 -1.92872707680398 6.31413417330173e-09 miRanda -0.301988192470538 2.13324863038677e-05 NA NA NA hsa-miR-148b-3p GADD45A 0.483970528590224 0.0026495409465901 0.295807344757299 0.218383996212033 MirTarget -0.340126647931105 6.86475415101894e-07 NA NA NA hsa-miR-203a-3p GADD45A 1.06866854356847 0.00389979689199624 0.295807344757299 0.218383996212033 MirTarget -0.110751485098685 0.000186426373565797 NA NA NA hsa-miR-375 GADD45A 0.615547997686534 0.149199273675144 0.295807344757299 0.218383996212033 miRanda -0.117305912118485 4.96620623755307e-06 NA NA NA hsa-miR-324-3p GADD45B -0.0774700133118458 0.689226297032231 -1.592999067635 1.71286942854757e-12 MirTarget;miRNATAP -0.153520773002313 0.00557801960543285 NA NA NA hsa-miR-590-3p GADD45B 0.83851360565783 0.00129224433453587 -1.592999067635 1.71286942854757e-12 miRanda -0.128384670833959 0.0087523414105501 NA NA NA hsa-miR-127-3p GADD45G -0.723429813065737 0.0192747925933947 0.558251242266569 0.0699587843678354 miRanda;miRNATAP -0.177067134124427 0.000105410370152299 NA NA NA hsa-miR-141-3p GNA12 3.36993755486106 5.42939251147195e-32 0.0489221484390701 0.723417535223969 mirMAP -0.131999691182969 7.46053457398313e-11 NA NA NA hsa-miR-181c-5p GNA12 0.529875814537156 0.0125885822998008 0.0489221484390701 0.723417535223969 mirMAP -0.100833223136381 0.000734757801055199 NA NA NA hsa-miR-186-5p GNA12 0.852175445703945 6.88885738584309e-10 0.0489221484390701 0.723417535223969 mirMAP -0.142402673926862 0.00181394310819958 NA NA NA hsa-miR-200a-3p GNA12 3.14766878548496 1.32850889777422e-21 0.0489221484390701 0.723417535223969 mirMAP -0.12887533486957 2.64547345045178e-12 NA NA NA hsa-miR-30d-3p GNA12 0.00396376345349925 0.986457040013182 0.0489221484390701 0.723417535223969 MirTarget -0.122288744606736 5.85591639209859e-05 NA NA NA hsa-miR-335-5p GNA12 -0.466533891325811 0.0676987038122831 0.0489221484390701 0.723417535223969 mirMAP -0.115619723687133 2.97471766402373e-05 NA NA NA hsa-miR-107 GNG12 0.658676029898313 5.11480446318819e-07 -0.481052982891586 0.0106970234636918 miRanda -0.240152271925136 0.000296272815140921 NA NA NA hsa-miR-590-3p GNG12 0.83851360565783 0.00129224433453587 -0.481052982891586 0.0106970234636918 miRanda;mirMAP -0.106371542166068 0.00772124644373765 NA NA NA hsa-miR-590-5p GNG12 2.07441240363458 4.95240551694843e-14 -0.481052982891586 0.0106970234636918 PITA -0.223723753830493 2.62733560738329e-09 NA NA NA hsa-miR-96-5p GNG12 3.0381097138467 4.40362891630201e-24 -0.481052982891586 0.0106970234636918 TargetScan -0.178457232594575 1.23065278598398e-08 NA NA NA hsa-miR-27b-3p GRB2 0.236438984240408 0.12263510345883 -0.210706496557246 0.0100478898753454 MirTarget;miRNATAP -0.113414213940692 3.83461454675988e-06 NA NA NA hsa-let-7a-5p HRAS -1.37014061604018 3.11451492971224e-14 0.139800610267073 0.358123351398595 miRNAWalker2_validate;miRTarBase -0.142144334211175 0.000164893588817854 18344688;20033209;20607356;23134218;19323605 Using an established orthotopic mouse lung cancer model we show that intranasal let-7 administration reduces tumor formation in vivo in the lungs of animals expressing a G12D activating mutation for the K-ras oncogene;k-Ras and c-Myc two key oncogenes in lung cancer have been found to be targeted by let-7 in vitro; The aim of the present study is to determine the effect of let-7a a member of let-7 family on the growth of lung cancer in vivo and to investigate whether let-7-induced suppression of k-Ras and c-Myc is involved in lung cancer; Overexpression of let-7a can inhibit the growth of lung cancer transplanted subcutaneously in nude mice by suppression of k-Ras and c-Myc;Transfection of let-7 miRNA reduced expression of pan-RAS N-RAS and K-RAS in the glioblastoma cells;MicroRNA let 7a inhibits the proliferation and invasion of nonsmall cell lung cancer cell line 95D by regulating K Ras and HMGA2 gene expression; K-RAS and HMGA2 mRNA levels were significantly higher in the let-7a overexpressed group than those in the let-7a inhibited group p < 0.05; However the protein levels of K-RAS and HMGA2 were significantly lower in the let-7a overexpressed group than those in the let-7a inhibited group p < 0.05; We suppose that let-7a inhibits the proliferation and invasion of the cell line 95D by regulating the translation of K-RAS and HMGA2 mRNA not the transcription of the mRNA itself;Because let-7 microRNA targets the K-ras oncogene we aimed to characterize let-7 expression and function in PDAC in vitro and in vivo; Restoring let-7 levels in cancer-derived cell lines strongly inhibits cell proliferation K-ras expression and mitogen-activated protein kinase activation but fails to impede tumor growth progression after intratumoral gene transfer or after implantation of Capan-1 cells stably overexpressing let-7 microRNA ;;;;progression lung cancer;lung cancer;glioblastoma;lung squamous cell cancer;pancreatic cancer hsa-miR-143-3p HRAS -1.21021691908494 5.70938667332876e-06 0.139800610267073 0.358123351398595 miRNAWalker2_validate;miRTarBase -0.125376896055055 1.11873626270013e-06 21276449 The Evi1 microRNA 143 K Ras axis in colon cancer colon cancer hsa-miR-146a-5p HSPA1A 0.684701497250824 0.0105316554224149 0.60900099108461 0.00371591092874843 miRNAWalker2_validate -0.127221905651547 0.000591869737328624 NA NA NA hsa-miR-335-5p HSPA1A -0.466533891325811 0.0676987038122831 0.60900099108461 0.00371591092874843 miRNAWalker2_validate -0.151380696262545 0.000359178918178948 NA NA NA hsa-let-7b-5p HSPA1B -1.62016148171663 1.56547487335694e-15 0.775450589715368 6.1597311708361e-05 miRNAWalker2_validate -0.173022761694715 5.14117520298105e-05 NA NA NA hsa-miR-30d-5p HSPA1B -0.920901858717441 3.50898334321668e-05 0.775450589715368 6.1597311708361e-05 miRNAWalker2_validate -0.160933147850241 5.59107548807716e-05 NA NA NA hsa-miR-378a-3p HSPA1B -2.0140903990983 1.146745431034e-18 0.775450589715368 6.1597311708361e-05 miRNAWalker2_validate -0.165177168948829 1.13442357428251e-05 NA NA NA hsa-miR-378a-5p HSPA1B -1.22647878854015 9.72314015412955e-08 0.775450589715368 6.1597311708361e-05 miRNAWalker2_validate -0.101902338481781 0.00826635925749824 NA NA NA hsa-miR-26a-5p HSPA8 -0.126411409001078 0.440028840408711 0.0569055608302378 0.6886867098448 miRNAWalker2_validate -0.113550039485136 0.00475859102893472 NA NA NA hsa-miR-320a HSPA8 -0.961144925954715 1.62478794429204e-08 0.0569055608302378 0.6886867098448 miRNAWalker2_validate -0.129756861301259 0.000625034133464092 NA NA NA hsa-miR-107 IKBKG 0.658676029898313 5.11480446318819e-07 0.0843830838323729 0.544710841322622 miRanda -0.126711425730293 0.00969342977912645 NA NA NA hsa-miR-143-3p IKBKG -1.21021691908494 5.70938667332876e-06 0.0843830838323729 0.544710841322622 mirMAP -0.162693115202678 2.58257152475095e-12 NA NA NA hsa-miR-17-3p IKBKG 1.36706429551147 4.60388403547821e-13 0.0843830838323729 0.544710841322622 mirMAP -0.124943383525099 0.000155383572679206 NA NA NA hsa-miR-24-3p IKBKG -0.0357874587555003 0.785865078836504 0.0843830838323729 0.544710841322622 mirMAP -0.14327021053209 0.00372994900140062 NA NA NA hsa-miR-330-3p IKBKG -0.716924999893351 0.000796236278616087 0.0843830838323729 0.544710841322622 mirMAP -0.174026313241355 3.45303704238481e-09 NA NA NA hsa-miR-141-3p IL1A 3.36993755486106 5.42939251147195e-32 -2.78589291846042 1.94445738122673e-09 MirTarget -0.425166348436577 1.11437754257848e-09 NA NA NA hsa-miR-181c-5p IL1A 0.529875814537156 0.0125885822998008 -2.78589291846042 1.94445738122673e-09 MirTarget -0.41989445653036 3.99923207839548e-05 NA NA NA hsa-miR-181d-5p IL1A 1.19058140522592 8.5908558852417e-09 -2.78589291846042 1.94445738122673e-09 MirTarget -0.495373056794971 1.57350244087555e-06 NA NA NA hsa-miR-200a-3p IL1A 3.14766878548496 1.32850889777422e-21 -2.78589291846042 1.94445738122673e-09 MirTarget -0.451074234294195 9.33609082814678e-13 NA NA NA hsa-miR-30b-5p IL1A 0.358144314839612 0.138026229059594 -2.78589291846042 1.94445738122673e-09 MirTarget -0.372796563568777 3.38432266671698e-05 NA NA NA hsa-miR-30d-5p IL1A -0.920901858717441 3.50898334321668e-05 -2.78589291846042 1.94445738122673e-09 MirTarget -0.356697596588321 0.000238401377855495 NA NA NA hsa-miR-30e-5p IL1A 1.60414100786743 3.78951090573667e-19 -2.78589291846042 1.94445738122673e-09 MirTarget -0.387129646844589 0.000947181744027959 NA NA NA hsa-miR-335-5p IL1A -0.466533891325811 0.0676987038122831 -2.78589291846042 1.94445738122673e-09 miRNAWalker2_validate -0.363571202142101 0.000134067450135358 NA NA NA hsa-miR-664a-3p IL1A 0.443077463053857 0.0214248925850984 -2.78589291846042 1.94445738122673e-09 MirTarget -0.399970970989528 0.000411462536175719 NA NA NA hsa-miR-7-1-3p IL1B 2.61364240402652 1.98959237815786e-32 -1.4197099567083 1.3846626069017e-05 MirTarget -0.204885242824381 0.00248885388859552 NA NA NA hsa-miR-130b-5p IL1R1 1.53645187062942 1.10498816261505e-08 -0.902036062273456 1.24728661303111e-05 mirMAP -0.20947298252971 1.38476702999555e-09 NA NA NA hsa-miR-17-3p IL1R1 1.36706429551147 4.60388403547821e-13 -0.902036062273456 1.24728661303111e-05 mirMAP -0.291254110034348 2.75619676884419e-09 NA NA NA hsa-miR-186-5p IL1R1 0.852175445703945 6.88885738584309e-10 -0.902036062273456 1.24728661303111e-05 mirMAP -0.330097048462088 1.4514081890525e-06 NA NA NA hsa-miR-26b-5p IL1R1 0.72362441215247 4.7794659748036e-05 -0.902036062273456 1.24728661303111e-05 mirMAP -0.151138951739801 0.00500687907349492 NA NA NA hsa-miR-335-3p IL1R1 1.51116383169018 6.88553098788624e-13 -0.902036062273456 1.24728661303111e-05 mirMAP -0.292160492099576 2.30254080656226e-11 NA NA NA hsa-miR-590-3p IL1R1 0.83851360565783 0.00129224433453587 -0.902036062273456 1.24728661303111e-05 miRanda;miRNATAP -0.166712189356744 0.00014487477422078 NA NA NA hsa-miR-940 JMJD7-PLA2G4B 0.011138136211269 0.974925352379525 -0.400430522628583 0.0339399904766164 miRNATAP -0.117383627060937 1.87570641851953e-05 NA NA NA hsa-miR-141-3p JUN 3.36993755486106 5.42939251147195e-32 -0.999359590084937 1.13112331580714e-06 miRNATAP -0.117569383056825 0.000149604234896854 NA NA NA hsa-miR-148a-5p JUN 1.45633512586855 1.81792463521257e-08 -0.999359590084937 1.13112331580714e-06 miRNATAP -0.104130733311401 0.00423603987630484 NA NA NA hsa-let-7a-3p KRAS 0.167285443861993 0.431834813181487 0.538115716643554 0.00142410994615815 mirMAP;miRNATAP -0.165605931792738 5.41329968030116e-05 24727325;20603437;24890702;23324806;21994416;23167843;27620744;20177422;25183481;22584434;18922928 Association study of the let 7 miRNA complementary site variant in the 3' untranslated region of the KRAS gene in stage III colon cancer NCCTG N0147 Clinical Trial; A let-7 microRNA-complementary site LCS6 polymorphism in the 3' untranslated region of the KRAS gene has been shown to disrupt let-7 binding and upregulate KRAS expression;A let 7 microRNA binding site polymorphism in 3' untranslated region of KRAS gene predicts response in wild type KRAS patients with metastatic colorectal cancer treated with cetuximab monotherapy; A polymorphism in a let-7 microRNA complementary site lcs6 in the KRAS 3' untranslated region UTR is associated with an increased cancer risk in non-small-cell lung cancer and reduced overall survival OS in oral cancers; the presence of KRAS let-7 lcs6 polymorphism was evaluated in 130 mCRC patients who were enrolled in a phase II study of cetuximab monotherapy IMCL-0144; KRAS let-7 lcs6 polymorphism was found to be related to object response rate ORR in mCRC patients whose tumors had KRASwt;Let 7 microRNA binding site polymorphism in the 3'UTR of KRAS and colorectal cancer outcome: a systematic review and meta analysis; There is a small but growing body of literature regarding the predictive utility of a Let-7 microRNA-binding-site polymorphism in the 3'-untranslated region UTR of KRAS KRAS-LCS6 for colorectal cancer outcome although the results are conflicting; A PubMed search was conducted to identify all studies reporting on KRAS let-7 microRNA-binding site polymorphism LCS6; rs61764370 and colorectal cancer outcome;The LCS6 polymorphism in the binding site of let 7 microRNA to the KRAS 3' untranslated region: its role in the efficacy of anti EGFR based therapy in metastatic colorectal cancer patients; The lethal-7 let-7 family of microRNAs regulates KRAS activity; We studied the association of the KRAS let-7 LCS6 polymorphism with the response in 100 refractory mCRC patients treated with anti-EGFR antibodies; The KRAS let-7 LCS6 polymorphism was genotyped using the BioMark system in blood and tumor DNA samples; The KRAS let-7 LCS6 G-allele showed a statistically significant association with nonresponse to anti-EGFR-based treatment: 31.9% of patients with the T/T genotype presented a complete or a partial response versus no patients with T/G or G/G genotypes P=0.004;A let 7 microRNA SNP in the KRAS 3'UTR is prognostic in early stage colorectal cancer; Recently a SNP in a lethal-7 let-7 miRNA complementary site LCS6 in the KRAS 3'untranslated region was suggested to affect survival in metastatic CRC;Let 7 miRNA binding site polymorphism in the KRAS 3'UTR; colorectal cancer screening population prevalence and influence on clinical outcome in patients with metastatic colorectal cancer treated with 5 fluorouracil and oxaliplatin +/ cetuximab; Recent studies have reported associations between a variant allele in a let-7 microRNA complementary site LCS6 within the 3'untranslated region 3'UTR of KRAS rs61764370 and clinical outcome in metastatic colorectal cancer mCRC patients receiving cetuximab;A let 7 microRNA binding site polymorphism in the KRAS 3'UTR is associated with increased risk and reduced survival for gallbladder cancer in North Indian population; The let-7 microRNAs play a key role in regulating KRAS expression and a polymorphism in 3' untranslated region rs61764370 T/G of KRAS leads to its higher expression;Genetic modulation of the Let 7 microRNA binding to KRAS 3' untranslated region and survival of metastatic colorectal cancer patients treated with salvage cetuximab irinotecan; There is increasing evidence that the Let-7 microRNA miRNA exerts an effect as a tumor suppressor by targeting the KRAS mRNA; The Let-7 complementary site LCS6 T>G variant in the KRAS 3'-untranslated region weakens Let-7 binding;A let 7 microRNA binding site polymorphism in KRAS predicts improved outcome in patients with metastatic colorectal cancer treated with salvage cetuximab/panitumumab monotherapy;High let 7a microRNA levels in KRAS mutated colorectal carcinomas may rescue anti EGFR therapy effects in patients with chemotherapy refractory metastatic disease; Preclinical and experimental data in vivo indicate that Lethal-7 Let-7 microRNA downregulates KRAS with antitumor effects in the presence of activating KRAS mutations; In 59 patients harboring KRAS mutations Let-7a levels were analyzed for association with overall survival OS and progression-free survival PFS times; An exploratory subgroup analysis was performed using the rs61764370 LCS6 T>G polymorphism that experimentally impairs Let-7 binding to KRAS mRNA; In patients with KRAS mutations Let-7a analysis may serve to identify subgroups of patients who may still benefit from EGFR inhibition and this may open up new perspectives for alternative treatment strategies;A SNP in a let 7 microRNA complementary site in the KRAS 3' untranslated region increases non small cell lung cancer risk; The purpose of this study was to identify single nucleotide polymorphisms SNP that could modify let-7 binding and to assess the effect of such SNPs on target gene regulation and risk for non-small cell lung cancer NSCLC let-7 complementary sites LCS were sequenced in the KRAS 3' untranslated region from 74 NSCLC cases to identify mutations and SNPs that correlated with NSCLC; The LCS6 variant allele in a KRAS miRANA complementary site is significantly associated with increased risk for NSCLC among moderate smokers and represents a new paradigm for let-7 miRNAs in lung cancer susceptibility staging;drug resistance;poor survival;;drug resistance;staging;poor survival;;poor survival;poor survival;;progression;poor survival; colon cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;bladder cancer;colorectal cancer;colorectal cancer;colorectal cancer;lung squamous cell cancer hsa-let-7b-3p KRAS -1.81889978084306 6.9913416210266e-19 0.538115716643554 0.00142410994615815 mirMAP;miRNATAP -0.21045052897075 5.92266664846517e-09 24727325;20603437;24890702;23324806;21994416;23167843;27620744;20177422;25183481;26581910;22584434;26516699;18922928 Association study of the let 7 miRNA complementary site variant in the 3' untranslated region of the KRAS gene in stage III colon cancer NCCTG N0147 Clinical Trial; A let-7 microRNA-complementary site LCS6 polymorphism in the 3' untranslated region of the KRAS gene has been shown to disrupt let-7 binding and upregulate KRAS expression;A let 7 microRNA binding site polymorphism in 3' untranslated region of KRAS gene predicts response in wild type KRAS patients with metastatic colorectal cancer treated with cetuximab monotherapy; A polymorphism in a let-7 microRNA complementary site lcs6 in the KRAS 3' untranslated region UTR is associated with an increased cancer risk in non-small-cell lung cancer and reduced overall survival OS in oral cancers; the presence of KRAS let-7 lcs6 polymorphism was evaluated in 130 mCRC patients who were enrolled in a phase II study of cetuximab monotherapy IMCL-0144; KRAS let-7 lcs6 polymorphism was found to be related to object response rate ORR in mCRC patients whose tumors had KRASwt;Let 7 microRNA binding site polymorphism in the 3'UTR of KRAS and colorectal cancer outcome: a systematic review and meta analysis; There is a small but growing body of literature regarding the predictive utility of a Let-7 microRNA-binding-site polymorphism in the 3'-untranslated region UTR of KRAS KRAS-LCS6 for colorectal cancer outcome although the results are conflicting; A PubMed search was conducted to identify all studies reporting on KRAS let-7 microRNA-binding site polymorphism LCS6; rs61764370 and colorectal cancer outcome;The LCS6 polymorphism in the binding site of let 7 microRNA to the KRAS 3' untranslated region: its role in the efficacy of anti EGFR based therapy in metastatic colorectal cancer patients; The lethal-7 let-7 family of microRNAs regulates KRAS activity; We studied the association of the KRAS let-7 LCS6 polymorphism with the response in 100 refractory mCRC patients treated with anti-EGFR antibodies; The KRAS let-7 LCS6 polymorphism was genotyped using the BioMark system in blood and tumor DNA samples; The KRAS let-7 LCS6 G-allele showed a statistically significant association with nonresponse to anti-EGFR-based treatment: 31.9% of patients with the T/T genotype presented a complete or a partial response versus no patients with T/G or G/G genotypes P=0.004;A let 7 microRNA SNP in the KRAS 3'UTR is prognostic in early stage colorectal cancer; Recently a SNP in a lethal-7 let-7 miRNA complementary site LCS6 in the KRAS 3'untranslated region was suggested to affect survival in metastatic CRC;Let 7 miRNA binding site polymorphism in the KRAS 3'UTR; colorectal cancer screening population prevalence and influence on clinical outcome in patients with metastatic colorectal cancer treated with 5 fluorouracil and oxaliplatin +/ cetuximab; Recent studies have reported associations between a variant allele in a let-7 microRNA complementary site LCS6 within the 3'untranslated region 3'UTR of KRAS rs61764370 and clinical outcome in metastatic colorectal cancer mCRC patients receiving cetuximab;A let 7 microRNA binding site polymorphism in the KRAS 3'UTR is associated with increased risk and reduced survival for gallbladder cancer in North Indian population; The let-7 microRNAs play a key role in regulating KRAS expression and a polymorphism in 3' untranslated region rs61764370 T/G of KRAS leads to its higher expression;Genetic modulation of the Let 7 microRNA binding to KRAS 3' untranslated region and survival of metastatic colorectal cancer patients treated with salvage cetuximab irinotecan; There is increasing evidence that the Let-7 microRNA miRNA exerts an effect as a tumor suppressor by targeting the KRAS mRNA; The Let-7 complementary site LCS6 T>G variant in the KRAS 3'-untranslated region weakens Let-7 binding;A let 7 microRNA binding site polymorphism in KRAS predicts improved outcome in patients with metastatic colorectal cancer treated with salvage cetuximab/panitumumab monotherapy;Our results showed that miR-143 but not let-7b increased sensitization of KRAS mutant tumor cells to paclitaxel; Furthermore transfection of miR-143 but not let-7b mimic negatively regulated the expression of mutant but not wild-type KRAS;Preclinical and experimental data in vivo indicate that Lethal-7 Let-7 microRNA downregulates KRAS with antitumor effects in the presence of activating KRAS mutations; An exploratory subgroup analysis was performed using the rs61764370 LCS6 T>G polymorphism that experimentally impairs Let-7 binding to KRAS mRNA;Interestingly the differential expression of miRNA in mice also corroborated with the miRNA expression in human PC cell lines and tissue samples; ectopic expression of Let-7b in CD18/HPAF and Capan1 cells resulted in the downregulation of KRAS and MSST1 expression;A SNP in a let 7 microRNA complementary site in the KRAS 3' untranslated region increases non small cell lung cancer risk; The purpose of this study was to identify single nucleotide polymorphisms SNP that could modify let-7 binding and to assess the effect of such SNPs on target gene regulation and risk for non-small cell lung cancer NSCLC let-7 complementary sites LCS were sequenced in the KRAS 3' untranslated region from 74 NSCLC cases to identify mutations and SNPs that correlated with NSCLC; The LCS6 variant allele in a KRAS miRANA complementary site is significantly associated with increased risk for NSCLC among moderate smokers and represents a new paradigm for let-7 miRNAs in lung cancer susceptibility staging;drug resistance;poor survival;;drug resistance;staging;poor survival;;poor survival;poor survival;;;;; colon cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;bladder cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;pancreatic cancer;lung squamous cell cancer hsa-miR-1-3p KRAS -1.48412019995919 0.000242034342580425 0.538115716643554 0.00142410994615815 MirTarget -0.1135101654678 3.65182035802432e-08 NA NA NA hsa-miR-126-3p KRAS 0.397563736477277 0.115641762947829 0.538115716643554 0.00142410994615815 miRNAWalker2_validate;miRTarBase -0.140662247102959 4.48695871977096e-06 22845403 miR-126 is also known to target other crucial oncogenes in PDAC such as KRAS and CRK pancreatic cancer hsa-miR-1271-5p KRAS -0.0172769786790662 0.951102370899887 0.538115716643554 0.00142410994615815 MirTarget -0.111352851066065 6.81606802337118e-05 NA NA NA hsa-miR-140-3p KRAS -1.11373309124537 8.35257079443689e-14 0.538115716643554 0.00142410994615815 MirTarget -0.379051955627805 3.51513569284386e-14 NA NA NA hsa-miR-155-5p KRAS 0.813513839059142 0.000608282725633232 0.538115716643554 0.00142410994615815 miRNAWalker2_validate;miRNATAP -0.136672576377435 2.71388112053399e-05 NA NA NA hsa-miR-16-1-3p KRAS 1.50034693398929 6.63958242991125e-10 0.538115716643554 0.00142410994615815 mirMAP -0.120692099076156 0.0020633534672843 NA NA NA hsa-miR-181a-5p KRAS -0.375429731222937 0.0562142867129802 0.538115716643554 0.00142410994615815 miRNAWalker2_validate -0.232892392323763 2.90389285591447e-09 24098024;27517749;26124189 The KRAS mutational status was determined by pyrosequencing and miR-181a expression was measured by quantitative RT-PCR in CRC tumour tissue and corresponding non-neoplastic colon tissue;Here we report that miR-181a directly binds to 3'-untranslated regions UTRs; downregulates KRAS NRAS and MAPK1; and decreases AML growth; The delivery of miR-181a mimics to target AML cells using transferrin-targeting lipopolyplex nanoparticles NP increased mature miR-181a; downregulated KRAS NRAS and MAPK1; and resulted in decreased phosphorylation of the downstream RAS effectors;MiR 181a 5p inhibits cell proliferation and migration by targeting Kras in non small cell lung cancer A549 cells; Luciferase activity assay results demonstrated that two binding sites of Kras could be directly targeted by miR-181a-5p; Furthermore Kras was down-regulated by miR-181a-5p at both transcriptional and translational levels; SiRNA-mediated Kras down-regulation could mimic the effects of miR-181a-5p mimic in A549 cells; Our findings suggest that miR-181a-5p plays a potential role in tumor suppression by partially targeting Kras and has the potential therapeutic application in NSCLC patients ;; colorectal cancer;acute myeloid leukemia;lung squamous cell cancer hsa-miR-181c-5p KRAS 0.529875814537156 0.0125885822998008 0.538115716643554 0.00142410994615815 miRNAWalker2_validate;miRTarBase -0.113481461651682 0.00199940913466899 NA NA NA hsa-miR-186-5p KRAS 0.852175445703945 6.88885738584309e-10 0.538115716643554 0.00142410994615815 mirMAP -0.173206213582145 0.0020136892983084 NA NA NA hsa-miR-193a-3p KRAS 0.549173467360291 0.0319030569365466 0.538115716643554 0.00142410994615815 MirTarget;miRanda;miRNATAP -0.114033878061734 0.000545245334645599 NA NA NA hsa-miR-193a-5p KRAS -1.15938257046946 2.61709321247277e-08 0.538115716643554 0.00142410994615815 miRNATAP -0.136206451672479 0.000220728848496 NA NA NA hsa-miR-195-3p KRAS -1.33068822339418 6.65427393047357e-09 0.538115716643554 0.00142410994615815 mirMAP -0.26052009331858 1.37547972270525e-15 NA NA NA hsa-miR-199a-5p KRAS 1.3057193856884 2.38429382751645e-08 0.538115716643554 0.00142410994615815 miRanda;miRNATAP -0.190569403157002 4.12804905993219e-09 NA NA NA hsa-miR-199b-5p KRAS 2.13822205171062 4.56262988762436e-15 0.538115716643554 0.00142410994615815 miRanda;miRNATAP -0.160083363830103 4.62674745647173e-09 27517624 The miR-199b prognostic impact was particularly evident in both younger and KRAS wild-type subgroups colorectal cancer hsa-miR-224-3p KRAS 0.921090817288022 0.010010047721564 0.538115716643554 0.00142410994615815 mirMAP -0.11580794239374 2.34601235413632e-07 25919696 MicroRNA 224 is associated with colorectal cancer progression and response to 5 fluorouracil based chemotherapy by KRAS dependent and independent mechanisms; MicroRNA-224 was differentially expressed in dysplastic colorectal disease and in isogeneic KRAS WT and mutant HCT116 cells; 5-FU chemosensitivity was significantly increased in miR-224 knockdown cells and in NIH3T3 cells expressing KRAS and BRAF mutant proteins progression;drug resistance colorectal cancer hsa-miR-27b-3p KRAS 0.236438984240408 0.12263510345883 0.538115716643554 0.00142410994615815 miRNATAP -0.140671332847896 0.00626162133896643 NA NA NA hsa-miR-30a-3p KRAS -2.54042202792785 2.9111625410859e-18 0.538115716643554 0.00142410994615815 MirTarget;miRNATAP -0.122460927678546 1.58218389307393e-06 NA NA NA hsa-miR-30a-5p KRAS -0.924084264430689 0.000762030454634728 0.538115716643554 0.00142410994615815 mirMAP;miRNATAP -0.160923145065632 7.88859261457886e-09 NA NA NA hsa-miR-30b-5p KRAS 0.358144314839612 0.138026229059594 0.538115716643554 0.00142410994615815 mirMAP;miRNATAP -0.147252408030935 4.51771159246383e-06 NA NA NA hsa-miR-30c-5p KRAS -0.327319105755825 0.123595832152687 0.538115716643554 0.00142410994615815 mirMAP;miRNATAP -0.303491851342304 1.38338910293015e-17 22701724 Deregulated miRNAs in hereditary breast cancer revealed a role for miR 30c in regulating KRAS oncogene; In particular we experimentally validated KRAS as a miR-30c target; Luciferase assays confirmed that miR-30c binds the 3'UTR of KRAS transcripts and expression of pre-miR-30c down-regulated KRAS mRNA and protein; In addition we provide evidence that KRAS is a target of miR-30c and that this miRNA suppresses breast cancer cell growth potentially through inhibition of KRAS signaling breast cancer hsa-miR-30d-3p KRAS 0.00396376345349925 0.986457040013182 0.538115716643554 0.00142410994615815 MirTarget;miRNATAP -0.12073831042602 0.00128170411687249 NA NA NA hsa-miR-30d-5p KRAS -0.920901858717441 3.50898334321668e-05 0.538115716643554 0.00142410994615815 mirMAP;miRNATAP -0.124035278299491 0.000357846902820112 NA NA NA hsa-miR-30e-3p KRAS -0.104420043859122 0.526240453209293 0.538115716643554 0.00142410994615815 MirTarget -0.254543853548427 7.09600327106139e-08 NA NA NA hsa-miR-30e-5p KRAS 1.60414100786743 3.78951090573667e-19 0.538115716643554 0.00142410994615815 mirMAP;miRNATAP -0.125942634043968 0.00267795482717309 NA NA NA hsa-miR-501-3p KRAS -0.0405952693028064 0.866802243505833 0.538115716643554 0.00142410994615815 MirTarget;PITA;TargetScan;miRNATAP -0.124338029852589 0.000111299015637681 NA NA NA hsa-miR-502-3p KRAS -0.262270070977708 0.161760375279961 0.538115716643554 0.00142410994615815 MirTarget;PITA;miRNATAP -0.116432061546502 0.00538025775498572 NA NA NA hsa-miR-532-5p KRAS 0.576620898517708 0.0023245812680956 0.538115716643554 0.00142410994615815 MirTarget;PITA;miRNATAP -0.123485597460216 0.00273306142385404 NA NA NA hsa-miR-30c-5p MAP2K1 -0.327319105755825 0.123595832152687 -0.126507255559492 0.255813608366235 miRNAWalker2_validate -0.148243346155614 3.94199903529302e-10 NA NA NA hsa-miR-497-5p MAP2K1 -0.0546347378264729 0.786205564901684 -0.126507255559492 0.255813608366235 miRNAWalker2_validate -0.146950542279665 4.9483059880063e-09 NA NA NA hsa-miR-199a-5p MAP2K4 1.3057193856884 2.38429382751645e-08 -0.271118657053405 0.00449950561538623 miRanda;miRNATAP -0.105678238721409 6.82457355630936e-09 NA NA NA hsa-miR-140-3p MAP2K6 -1.11373309124537 8.35257079443689e-14 0.584081258505503 0.0861066821972578 MirTarget -0.341697838818838 0.000929633093264556 NA NA NA hsa-miR-186-5p MAP3K1 0.852175445703945 6.88885738584309e-10 0.0823047446973364 0.546549995877235 miRNATAP -0.136355790761015 0.00249852472018114 NA NA NA hsa-miR-18a-5p MAP3K1 1.37435209536521 9.2173853686829e-06 0.0823047446973364 0.546549995877235 miRNATAP -0.117296785662147 4.6978450841567e-08 NA NA NA hsa-miR-590-3p MAP3K1 0.83851360565783 0.00129224433453587 0.0823047446973364 0.546549995877235 PITA;miRanda;mirMAP -0.109861048392724 0.000126440820739581 NA NA NA hsa-miR-590-5p MAP3K1 2.07441240363458 4.95240551694843e-14 0.0823047446973364 0.546549995877235 PITA;miRanda;miRNATAP -0.164262299474182 1.28215776607778e-09 NA NA NA hsa-miR-93-5p MAP3K1 1.50844106515467 1.83836866996875e-12 0.0823047446973364 0.546549995877235 miRNATAP -0.133653266398382 2.56850115191078e-06 NA NA NA hsa-miR-106b-5p MAP3K12 1.47447672652218 1.32004094930462e-13 -0.482243289436743 0.00439947556869199 MirTarget -0.142434227200422 0.000193317599557981 NA NA NA hsa-miR-590-3p MAP3K12 0.83851360565783 0.00129224433453587 -0.482243289436743 0.00439947556869199 miRanda -0.107029812752569 0.00283399876436448 NA NA NA hsa-miR-1271-5p MAP3K13 -0.0172769786790662 0.951102370899887 0.449416452865153 0.0640962890912219 mirMAP -0.121962045846193 0.00246025297126002 NA NA NA hsa-miR-1301-3p MAP3K13 0.845987603184611 0.000579808501723616 0.449416452865153 0.0640962890912219 MirTarget -0.189345271474538 2.69306043047033e-05 NA NA NA hsa-miR-17-5p MAP3K13 2.07078488653279 2.77403038572568e-19 0.449416452865153 0.0640962890912219 miRNATAP -0.158601266603913 0.000656597303329326 NA NA NA hsa-miR-20a-3p MAP3K13 2.51803599558247 4.92479325298629e-13 0.449416452865153 0.0640962890912219 mirMAP -0.162770140510632 5.21481345082354e-05 NA NA NA hsa-miR-22-5p MAP3K13 1.71436244278242 9.85038001236064e-15 0.449416452865153 0.0640962890912219 mirMAP -0.171982890803909 0.000450767019446437 NA NA NA hsa-miR-320b MAP3K13 0.226640952564488 0.378818692487242 0.449416452865153 0.0640962890912219 mirMAP -0.181062089121883 2.8914574672244e-05 NA NA NA hsa-miR-363-3p MAP3K13 -0.301366430789287 0.414451883803084 0.449416452865153 0.0640962890912219 mirMAP -0.109455576165311 0.000301237586456882 NA NA NA hsa-miR-421 MAP3K13 0.170525317701774 0.535277026680289 0.449416452865153 0.0640962890912219 MirTarget -0.188745877937259 1.79942604332219e-05 NA NA NA hsa-miR-582-5p MAP3K13 1.08286181406653 0.00149040450161757 0.449416452865153 0.0640962890912219 miRNATAP -0.184472614893742 2.45369950040747e-08 NA NA NA hsa-miR-708-5p MAP3K13 3.04047795672813 3.01085192850869e-20 0.449416452865153 0.0640962890912219 MirTarget;miRNATAP -0.147767418958258 4.28561735919949e-05 NA NA NA hsa-miR-106b-5p MAP3K14 1.47447672652218 1.32004094930462e-13 -0.508395608018966 0.005388667824716 MirTarget -0.148081791172922 0.000331285249363202 NA NA NA hsa-miR-17-3p MAP3K14 1.36706429551147 4.60388403547821e-13 -0.508395608018966 0.005388667824716 MirTarget -0.160398561527579 0.000231985049439229 NA NA NA hsa-miR-101-5p MAP3K2 -0.0265235292039296 0.917878791358577 0.173453287305867 0.198836031526626 mirMAP -0.151675745590294 3.56444732781753e-07 NA NA NA hsa-miR-139-5p MAP3K2 -2.26625553116965 7.22375119369519e-16 0.173453287305867 0.198836031526626 miRanda;mirMAP -0.112724971823048 9.44402470756328e-08 NA NA NA hsa-miR-148b-5p MAP3K2 1.39335695292409 2.13220380550073e-07 0.173453287305867 0.198836031526626 mirMAP -0.100473782553098 0.00023332242082876 NA NA NA hsa-miR-17-5p MAP3K2 2.07078488653279 2.77403038572568e-19 0.173453287305867 0.198836031526626 MirTarget;TargetScan;miRNATAP -0.113681858064105 9.63854537039088e-06 NA NA NA hsa-miR-181a-5p MAP3K2 -0.375429731222937 0.0562142867129802 0.173453287305867 0.198836031526626 mirMAP -0.164229336857409 1.59632699895681e-07 NA NA NA hsa-miR-181b-5p MAP3K2 0.668793269169928 0.000239998092406404 0.173453287305867 0.198836031526626 mirMAP -0.121027911587055 0.000367485597020143 NA NA NA hsa-miR-186-5p MAP3K2 0.852175445703945 6.88885738584309e-10 0.173453287305867 0.198836031526626 MirTarget;miRNATAP -0.165060911027222 0.000209064524632084 27498924 MicroRNA 186 suppresses cell proliferation and metastasis through targeting MAP3K2 in non small cell lung cancer; Furthermore we observed tthat the overexpression of MAP3K2 partially reversed the inhibitory effect of miR-186 on the proliferation and metastasis of A549 and HCC827 cell lines; Taken together our data indicated that miR-186 regulates lung cancer growth and metastasis through suppressing MAP3K2 expression at least partly metastasis lung squamous cell cancer hsa-miR-19a-3p MAP3K2 2.11776595911517 7.07663078397156e-10 0.173453287305867 0.198836031526626 MirTarget;mirMAP;miRNATAP -0.133188322336188 1.48853155977219e-10 NA NA NA hsa-miR-19b-3p MAP3K2 2.10868505662119 5.40846613768389e-17 0.173453287305867 0.198836031526626 MirTarget;mirMAP;miRNATAP -0.13879579093684 2.13156977405893e-08 NA NA NA hsa-miR-20a-5p MAP3K2 2.64649625616975 5.1469418982085e-27 0.173453287305867 0.198836031526626 MirTarget;miRNATAP -0.110296606631383 3.01732022065449e-06 NA NA NA hsa-miR-22-5p MAP3K2 1.71436244278242 9.85038001236064e-15 0.173453287305867 0.198836031526626 MirTarget -0.155807917277302 6.61765225879884e-09 NA NA NA hsa-miR-26a-2-3p MAP3K2 0.264287787772609 0.305653616292982 0.173453287305867 0.198836031526626 mirMAP -0.173668030716925 4.55408479436047e-09 NA NA NA hsa-miR-26b-5p MAP3K2 0.72362441215247 4.7794659748036e-05 0.173453287305867 0.198836031526626 mirMAP;miRNATAP -0.190399098195238 3.09732535034236e-08 NA NA NA hsa-miR-27b-3p MAP3K2 0.236438984240408 0.12263510345883 0.173453287305867 0.198836031526626 miRNATAP -0.11538433817823 0.00481051646093074 NA NA NA hsa-miR-30b-5p MAP3K2 0.358144314839612 0.138026229059594 0.173453287305867 0.198836031526626 mirMAP;miRNATAP -0.188281492051109 5.90093335586034e-14 NA NA NA hsa-miR-30c-5p MAP3K2 -0.327319105755825 0.123595832152687 0.173453287305867 0.198836031526626 mirMAP;miRNATAP -0.253507898514383 2.22214652467605e-19 NA NA NA hsa-miR-320a MAP3K2 -0.961144925954715 1.62478794429204e-08 0.173453287305867 0.198836031526626 miRanda;mirMAP -0.110217992441092 0.00227519925492122 NA NA NA hsa-miR-342-3p MAP3K2 -0.128691966564961 0.561034080130801 0.173453287305867 0.198836031526626 MirTarget;miRanda -0.15455927787491 2.62287037510207e-08 NA NA NA hsa-miR-664a-3p MAP3K2 0.443077463053857 0.0214248925850984 0.173453287305867 0.198836031526626 mirMAP -0.227339089888997 5.90182020283739e-13 NA NA NA hsa-miR-106a-5p MAP3K3 1.3902608059488 6.07931522284525e-05 -1.14767015293789 1.13947111671358e-17 MirTarget;miRNATAP -0.115417159662485 1.09001171217537e-08 NA NA NA hsa-miR-106b-5p MAP3K3 1.47447672652218 1.32004094930462e-13 -1.14767015293789 1.13947111671358e-17 MirTarget;miRNATAP -0.266341087451954 1.29810919695286e-18 NA NA NA hsa-miR-107 MAP3K3 0.658676029898313 5.11480446318819e-07 -1.14767015293789 1.13947111671358e-17 PITA;miRanda;miRNATAP -0.194523171240632 6.61240342332219e-05 NA NA NA hsa-miR-141-3p MAP3K3 3.36993755486106 5.42939251147195e-32 -1.14767015293789 1.13947111671358e-17 miRNATAP -0.19314046004418 2.72779742262484e-22 NA NA NA hsa-miR-16-5p MAP3K3 0.749619098384047 4.11649450706988e-06 -1.14767015293789 1.13947111671358e-17 MirTarget;miRNATAP -0.103380222383782 0.00848322326050329 NA NA NA hsa-miR-17-5p MAP3K3 2.07078488653279 2.77403038572568e-19 -1.14767015293789 1.13947111671358e-17 MirTarget;TargetScan;miRNATAP -0.189679455869463 3.22446554178547e-13 NA NA NA hsa-miR-181d-5p MAP3K3 1.19058140522592 8.5908558852417e-09 -1.14767015293789 1.13947111671358e-17 MirTarget -0.116152873992343 0.000135301327896242 NA NA NA hsa-miR-182-5p MAP3K3 3.21839823004635 5.13049145201115e-39 -1.14767015293789 1.13947111671358e-17 miRNATAP -0.17260815452637 1.12029534794451e-13 NA NA NA hsa-miR-193b-3p MAP3K3 1.10444771306846 0.000822888533401377 -1.14767015293789 1.13947111671358e-17 miRNAWalker2_validate;miRNATAP -0.116959872215266 6.79135085437139e-10 NA NA NA hsa-miR-20a-5p MAP3K3 2.64649625616975 5.1469418982085e-27 -1.14767015293789 1.13947111671358e-17 MirTarget;miRNATAP -0.15280449167853 2.42284282172735e-10 NA NA NA hsa-miR-212-3p MAP3K3 0.404496907089793 0.103551762277891 -1.14767015293789 1.13947111671358e-17 MirTarget -0.123841245794657 1.26554043921521e-06 NA NA NA hsa-miR-22-3p MAP3K3 1.42501909916631 1.72295005910055e-25 -1.14767015293789 1.13947111671358e-17 MirTarget;miRNATAP -0.133696766462175 0.00288558999438523 NA NA NA hsa-miR-28-5p MAP3K3 1.19639196514745 4.59365801666536e-18 -1.14767015293789 1.13947111671358e-17 MirTarget;PITA;miRanda;miRNATAP -0.162683503200536 0.000305277042448165 NA NA NA hsa-miR-7-1-3p MAP3K3 2.61364240402652 1.98959237815786e-32 -1.14767015293789 1.13947111671358e-17 mirMAP -0.148819835544172 1.37810309789848e-07 NA NA NA hsa-miR-708-5p MAP3K3 3.04047795672813 3.01085192850869e-20 -1.14767015293789 1.13947111671358e-17 MirTarget;miRNATAP -0.11624149107773 1.38214592890722e-08 NA NA NA hsa-miR-93-5p MAP3K3 1.50844106515467 1.83836866996875e-12 -1.14767015293789 1.13947111671358e-17 MirTarget;miRNATAP -0.152846986159195 1.26214453279423e-07 NA NA NA hsa-miR-96-5p MAP3K3 3.0381097138467 4.40362891630201e-24 -1.14767015293789 1.13947111671358e-17 MirTarget;TargetScan;miRNATAP -0.158008812132307 4.85266561597409e-12 NA NA NA hsa-miR-106a-5p MAP3K5 1.3902608059488 6.07931522284525e-05 -0.264576573576257 0.120489899061564 miRNATAP -0.132804850004551 8.55856979595023e-08 NA NA NA hsa-miR-106b-5p MAP3K5 1.47447672652218 1.32004094930462e-13 -0.264576573576257 0.120489899061564 miRNATAP -0.232280565995049 8.46264236208779e-10 NA NA NA hsa-miR-17-5p MAP3K5 2.07078488653279 2.77403038572568e-19 -0.264576573576257 0.120489899061564 TargetScan;miRNATAP -0.242658724634544 2.46315334627576e-14 NA NA NA hsa-miR-20a-5p MAP3K5 2.64649625616975 5.1469418982085e-27 -0.264576573576257 0.120489899061564 miRNATAP -0.20421571043835 4.1104382767929e-12 NA NA NA hsa-miR-93-5p MAP3K5 1.50844106515467 1.83836866996875e-12 -0.264576573576257 0.120489899061564 miRNATAP -0.19194924949943 6.01108309527808e-08 NA NA NA hsa-miR-181a-5p MAP3K7 -0.375429731222937 0.0562142867129802 0.116252164339675 0.274405047174939 MirTarget -0.111698155657412 6.22522745685755e-06 NA NA NA hsa-miR-181c-5p MAP3K7 0.529875814537156 0.0125885822998008 0.116252164339675 0.274405047174939 MirTarget -0.129190904013072 1.22677438228686e-08 NA NA NA hsa-miR-200a-3p MAP3K7 3.14766878548496 1.32850889777422e-21 0.116252164339675 0.274405047174939 miRNATAP -0.102466967282915 3.97764933743127e-13 NA NA NA hsa-miR-30d-3p MAP3K7 0.00396376345349925 0.986457040013182 0.116252164339675 0.274405047174939 MirTarget -0.118805888412381 3.21288737812328e-07 NA NA NA hsa-miR-34a-5p MAP3K7 1.40588612517769 8.60097477768592e-12 0.116252164339675 0.274405047174939 miRNAWalker2_validate -0.120284247295212 1.63104067360889e-07 NA NA NA hsa-miR-664a-3p MAP3K7 0.443077463053857 0.0214248925850984 0.116252164339675 0.274405047174939 MirTarget;mirMAP -0.176609609279063 1.12063711674263e-12 NA NA NA hsa-miR-106b-5p MAP3K8 1.47447672652218 1.32004094930462e-13 -1.27393084791015 8.40794175938796e-11 MirTarget;miRNATAP -0.121098816762563 0.00747270412766498 NA NA NA hsa-miR-128-3p MAP3K8 1.03509868349735 2.11606310588315e-10 -1.27393084791015 8.40794175938796e-11 MirTarget -0.189519559880918 0.000692630897670316 NA NA NA hsa-miR-181b-5p MAP3K8 0.668793269169928 0.000239998092406404 -1.27393084791015 8.40794175938796e-11 MirTarget -0.243961515460589 1.20707066350032e-06 NA NA NA hsa-miR-589-5p MAP3K8 0.233778899379261 0.228477190986199 -1.27393084791015 8.40794175938796e-11 MirTarget;miRNATAP -0.145610404777099 0.00229226708586108 NA NA NA hsa-miR-590-5p MAP3K8 2.07441240363458 4.95240551694843e-14 -1.27393084791015 8.40794175938796e-11 PITA;miRanda -0.107526767571815 0.00790056085494971 NA NA NA hsa-miR-93-5p MAP3K8 1.50844106515467 1.83836866996875e-12 -1.27393084791015 8.40794175938796e-11 MirTarget;miRNATAP -0.111025217663226 0.00848944208017592 NA NA NA hsa-let-7a-3p MAP4K3 0.167285443861993 0.431834813181487 0.222249126286683 0.0537519877977262 mirMAP -0.131165600825336 2.29639133687973e-06 NA NA NA hsa-let-7i-5p MAP4K3 0.605080599172936 1.48406814653206e-06 0.222249126286683 0.0537519877977262 MirTarget;miRNATAP -0.122775730723012 0.00375943952683295 NA NA NA hsa-miR-155-5p MAP4K3 0.813513839059142 0.000608282725633232 0.222249126286683 0.0537519877977262 MirTarget -0.136065321209034 4.86217436598737e-10 NA NA NA hsa-miR-22-5p MAP4K3 1.71436244278242 9.85038001236064e-15 0.222249126286683 0.0537519877977262 MirTarget -0.107054263077201 3.47575683313424e-06 NA NA NA hsa-miR-26b-5p MAP4K3 0.72362441215247 4.7794659748036e-05 0.222249126286683 0.0537519877977262 miRNAWalker2_validate -0.105386360607641 0.000375704570407862 NA NA NA hsa-miR-342-3p MAP4K3 -0.128691966564961 0.561034080130801 0.222249126286683 0.0537519877977262 miRanda -0.170263820927593 3.6634751582292e-13 NA NA NA hsa-miR-374b-5p MAP4K3 0.474691035780475 0.0109217471394203 0.222249126286683 0.0537519877977262 MirTarget;mirMAP;miRNATAP -0.106613076404161 0.000374367103411846 NA NA NA hsa-miR-29a-3p MAP4K4 0.101650412194573 0.573201097011668 -0.00744632720756933 0.964153766798505 miRNATAP -0.110101303989374 0.00964821838540111 NA NA NA hsa-miR-29b-3p MAP4K4 3.10527711861309 3.01242507282711e-32 -0.00744632720756933 0.964153766798505 miRNATAP -0.107433710813924 6.43766706864453e-05 NA NA NA hsa-miR-34a-5p MAP4K4 1.40588612517769 8.60097477768592e-12 -0.00744632720756933 0.964153766798505 MirTarget -0.149455484543812 3.43166022975761e-05 NA NA NA hsa-miR-96-5p MAP4K4 3.0381097138467 4.40362891630201e-24 -0.00744632720756933 0.964153766798505 TargetScan -0.108527283614765 8.85429854346923e-05 NA NA NA hsa-miR-130a-3p MAPK1 0.881660100597014 0.000158893668519248 -0.313704159534906 0.0065740365500908 mirMAP -0.101872197195 5.97373126035408e-06 NA NA NA hsa-miR-140-5p MAPK1 0.669142684153918 0.000335928403032308 -0.313704159534906 0.0065740365500908 miRanda -0.105360739553965 0.000299450445528468 NA NA NA hsa-miR-148a-3p MAPK1 2.30885799126944 1.95226081368985e-21 -0.313704159534906 0.0065740365500908 mirMAP -0.102558880400122 7.51166113357563e-07 NA NA NA hsa-miR-24-1-5p MAPK1 0.856025727237819 0.000107354490323658 -0.313704159534906 0.0065740365500908 mirMAP -0.114103342147363 5.37066958548902e-06 NA NA NA hsa-miR-29a-5p MAPK1 1.89519956688438 1.03453349363915e-11 -0.313704159534906 0.0065740365500908 mirMAP -0.100646824836984 5.49015969248301e-06 NA NA NA hsa-miR-29b-3p MAPK1 3.10527711861309 3.01242507282711e-32 -0.313704159534906 0.0065740365500908 mirMAP -0.122356815748067 3.56933939779318e-11 24767251 The percentage of positive myeloid cell leukemia sequence 1 ATG9A and MAPK10 protein expression and low miR-29b mRNA expression were significantly higher in cases with clinical stage III and IV ovarian cancer than in cases with clinical stage II ovarian cancer; Univariate Kaplan-Meier analysis showed a negative correlation between MAPK10 or ATG9A protein expression and overall as well as progression-free survival whereas a positive correlation was observed between miR-29b mRNA expression and overall as well as progression-free survival; Multivariate Cox regression analysis showed that elevated MAPK10 or ATG9A protein and lowered miR-29b mRNA expression in ovarian carcinoma was an independent poor prognostic predictor; Our study suggested that miR-29b mRNA MAPK10 protein expression and ATG9A protein expression are closely related to chemosensitivity of ovarian carcinoma staging;progression;poor survival ovarian cancer hsa-miR-342-3p MAPK1 -0.128691966564961 0.561034080130801 -0.313704159534906 0.0065740365500908 miRanda;mirMAP -0.137175460423021 7.76879946497687e-09 NA NA NA hsa-miR-34a-5p MAPK1 1.40588612517769 8.60097477768592e-12 -0.313704159534906 0.0065740365500908 mirMAP -0.105828142272272 2.59913448288353e-05 NA NA NA hsa-miR-454-3p MAPK1 1.49453641052169 4.46235742871434e-09 -0.313704159534906 0.0065740365500908 mirMAP -0.104171229052281 2.01455003951624e-05 NA NA NA hsa-miR-130b-3p MAPK10 1.83046548750752 5.04753914574694e-13 -1.84555409354538 2.44653235090281e-07 miRNATAP -0.537034366335229 2.86966630336949e-16 NA NA NA hsa-miR-193a-3p MAPK10 0.549173467360291 0.0319030569365466 -1.84555409354538 2.44653235090281e-07 miRanda;miRNATAP -0.208049144667707 0.0032825904748623 NA NA NA hsa-miR-19a-3p MAPK10 2.11776595911517 7.07663078397156e-10 -1.84555409354538 2.44653235090281e-07 miRNATAP -0.265750080258195 2.59683060133796e-06 NA NA NA hsa-miR-19b-3p MAPK10 2.10868505662119 5.40846613768389e-17 -1.84555409354538 2.44653235090281e-07 miRNATAP -0.189921398261328 0.00493497607488942 NA NA NA hsa-miR-29b-3p MAPK10 3.10527711861309 3.01242507282711e-32 -1.84555409354538 2.44653235090281e-07 miRNATAP -0.171823093280894 0.0036980764764073 24767251 The percentage of positive myeloid cell leukemia sequence 1 ATG9A and MAPK10 protein expression and low miR-29b mRNA expression were significantly higher in cases with clinical stage III and IV ovarian cancer than in cases with clinical stage II ovarian cancer; Univariate Kaplan-Meier analysis showed a negative correlation between MAPK10 or ATG9A protein expression and overall as well as progression-free survival whereas a positive correlation was observed between miR-29b mRNA expression and overall as well as progression-free survival; Multivariate Cox regression analysis showed that elevated MAPK10 or ATG9A protein and lowered miR-29b mRNA expression in ovarian carcinoma was an independent poor prognostic predictor; Our study suggested that miR-29b mRNA MAPK10 protein expression and ATG9A protein expression are closely related to chemosensitivity of ovarian carcinoma staging;progression;poor survival ovarian cancer hsa-miR-301a-3p MAPK10 2.70198002906399 1.56420889710984e-14 -1.84555409354538 2.44653235090281e-07 miRNATAP -0.174017260988062 0.00229185658757323 NA NA NA hsa-miR-450b-5p MAPK10 1.69248953402469 1.96052058003353e-07 -1.84555409354538 2.44653235090281e-07 mirMAP -0.186795960249825 0.000949224747958845 NA NA NA hsa-miR-582-5p MAPK10 1.08286181406653 0.00149040450161757 -1.84555409354538 2.44653235090281e-07 PITA -0.23826284159421 1.53674093759886e-06 NA NA NA hsa-miR-590-3p MAPK10 0.83851360565783 0.00129224433453587 -1.84555409354538 2.44653235090281e-07 miRanda;mirMAP -0.487483452887983 9.33422066806689e-11 NA NA NA hsa-miR-590-5p MAPK10 2.07441240363458 4.95240551694843e-14 -1.84555409354538 2.44653235090281e-07 PITA;miRanda;miRNATAP -0.563200566282606 2.40959066969729e-15 NA NA NA hsa-miR-940 MAPK10 0.011138136211269 0.974925352379525 -1.84555409354538 2.44653235090281e-07 PITA;miRNATAP -0.159477320006351 0.00256734578442865 NA NA NA hsa-let-7a-3p MAPK8 0.167285443861993 0.431834813181487 0.0632162214250305 0.668341664440464 mirMAP -0.157930246462243 9.14454944313728e-06 NA NA NA hsa-miR-125a-5p MAPK8 -1.04824536696301 3.97386082850476e-07 0.0632162214250305 0.668341664440464 miRNAWalker2_validate -0.15184015518388 2.49402331215943e-06 NA NA NA hsa-miR-140-3p MAPK8 -1.11373309124537 8.35257079443689e-14 0.0632162214250305 0.668341664440464 miRNAWalker2_validate -0.229670226577472 2.02179196215716e-07 NA NA NA hsa-miR-195-3p MAPK8 -1.33068822339418 6.65427393047357e-09 0.0632162214250305 0.668341664440464 mirMAP -0.164652345751543 1.11399258189077e-08 NA NA NA hsa-miR-214-3p MAPK8 -1.1136198715556 3.52054933799089e-05 0.0632162214250305 0.668341664440464 miRNAWalker2_validate -0.129072885991343 1.85416115952081e-07 19859982 HeLa cells that stably overexpress miR-214 downregulate the expression of MEK3 and JNK1 at both mRNA and protein levels; Further investigation revealed that miR-214 regulates the expression of MEK3 and JNK1 by targeting the 3'UTRs of these genes; Collectively these results suggest that miR-214 negatively regulates HeLa cell proliferation by targeting the noncoding regions of MEK3 and JNK1 mRNAs cervical and endocervical cancer hsa-miR-22-5p MAPK8 1.71436244278242 9.85038001236064e-15 0.0632162214250305 0.668341664440464 mirMAP -0.167203909807138 1.25459746890825e-08 NA NA NA hsa-miR-29a-5p MAPK8 1.89519956688438 1.03453349363915e-11 0.0632162214250305 0.668341664440464 mirMAP -0.109660256227403 0.000108946728883364 NA NA NA hsa-miR-30a-5p MAPK8 -0.924084264430689 0.000762030454634728 0.0632162214250305 0.668341664440464 mirMAP -0.132224175920583 5.22028416854406e-08 NA NA NA hsa-miR-30b-5p MAPK8 0.358144314839612 0.138026229059594 0.0632162214250305 0.668341664440464 mirMAP -0.189225193682518 6.26006883961534e-12 NA NA NA hsa-miR-30c-5p MAPK8 -0.327319105755825 0.123595832152687 0.0632162214250305 0.668341664440464 mirMAP -0.293359915087209 9.16213981476922e-22 NA NA NA hsa-miR-30e-5p MAPK8 1.60414100786743 3.78951090573667e-19 0.0632162214250305 0.668341664440464 mirMAP -0.114539805431751 0.00167549358780215 NA NA NA hsa-miR-221-5p MAPK8IP1 -2.2173523967387 1.8954728277084e-09 -0.131718040013204 0.58252523405645 MirTarget -0.110589904124823 0.000244949412705815 NA NA NA hsa-let-7a-5p MAPK8IP2 -1.37014061604018 3.11451492971224e-14 0.539475258408789 0.181981178080396 mirMAP -0.472846669201084 2.31951082263652e-06 NA NA NA hsa-let-7b-5p MAPK8IP2 -1.62016148171663 1.56547487335694e-15 0.539475258408789 0.181981178080396 mirMAP -0.370462054831954 2.91902942674055e-05 NA NA NA hsa-let-7f-5p MAPK8IP2 -0.0523311272618407 0.83407808268787 0.539475258408789 0.181981178080396 mirMAP -0.211575685439054 0.00464375341231759 NA NA NA hsa-miR-125b-2-3p MAPK8IP2 -1.71462405245374 1.47042341386638e-10 0.539475258408789 0.181981178080396 mirMAP -0.267389042697839 8.34460280147539e-05 NA NA NA hsa-miR-125b-5p MAPK8IP2 -0.548859243919575 0.0107224406584463 0.539475258408789 0.181981178080396 mirMAP -0.377638549138161 1.17114062680681e-05 NA NA NA hsa-miR-195-5p MAPK8IP2 -1.01577502605386 4.80814718341729e-05 0.539475258408789 0.181981178080396 mirMAP -0.219674709962259 0.00492321807096652 NA NA NA hsa-miR-125a-3p MAPK8IP3 -1.04954492275266 2.45974219476832e-06 1.16548831282062 4.79278117896756e-06 miRanda -0.228024215577134 1.40199206781021e-05 NA NA NA hsa-miR-128-3p MAPK8IP3 1.03509868349735 2.11606310588315e-10 1.16548831282062 4.79278117896756e-06 MirTarget -0.205111151697995 0.00434898882645397 NA NA NA hsa-miR-221-5p MAPK8IP3 -2.2173523967387 1.8954728277084e-09 1.16548831282062 4.79278117896756e-06 miRNATAP -0.326393817955632 2.94002916889012e-26 NA NA NA hsa-miR-590-5p MAPK9 2.07441240363458 4.95240551694843e-14 -0.0267974823319514 0.832365388512273 miRanda -0.113762314687669 6.92148479015732e-06 NA NA NA hsa-miR-93-5p MAPK9 1.50844106515467 1.83836866996875e-12 -0.0267974823319514 0.832365388512273 miRNAWalker2_validate;miRNATAP -0.122466377512421 3.34521997692581e-06 NA NA NA hsa-miR-128-3p MAPKAPK3 1.03509868349735 2.11606310588315e-10 -0.348682372957655 0.0255209675217176 MirTarget -0.213442860654922 7.98428808357436e-07 NA NA NA hsa-miR-421 MAPKAPK3 0.170525317701774 0.535277026680289 -0.348682372957655 0.0255209675217176 miRanda -0.105470928337545 0.000199541167159307 NA NA NA hsa-miR-132-3p MAPT 0.0122601212105202 0.934032846062939 -1.27395493419232 0.000786455208229158 MirTarget -0.329885525174342 0.00607801847249919 NA NA NA hsa-miR-148b-5p MAPT 1.39335695292409 2.13220380550073e-07 -1.27395493419232 0.000786455208229158 mirMAP -0.309144328730133 6.3276643819761e-05 NA NA NA hsa-miR-17-3p MAPT 1.36706429551147 4.60388403547821e-13 -1.27395493419232 0.000786455208229158 mirMAP -0.24430400576845 0.00733083596678729 NA NA NA hsa-miR-212-3p MAPT 0.404496907089793 0.103551762277891 -1.27395493419232 0.000786455208229158 MirTarget -0.235399616463013 0.00086742235452996 NA NA NA hsa-miR-27a-3p MAPT 0.433402568013802 0.00737164631768323 -1.27395493419232 0.000786455208229158 miRNATAP -0.353837241906515 0.00119639834046723 NA NA NA hsa-miR-28-5p MAPT 1.19639196514745 4.59365801666536e-18 -1.27395493419232 0.000786455208229158 mirMAP -0.411981329093588 0.000884326409718628 NA NA NA hsa-miR-450b-5p MAPT 1.69248953402469 1.96052058003353e-07 -1.27395493419232 0.000786455208229158 mirMAP -0.202377150554491 0.000666777630385973 NA NA NA hsa-miR-582-3p MAPT 1.70881364237226 1.26508456000083e-06 -1.27395493419232 0.000786455208229158 PITA;miRNATAP -0.286387281096306 3.51302696876924e-09 NA NA NA hsa-miR-7-1-3p MAPT 2.61364240402652 1.98959237815786e-32 -1.27395493419232 0.000786455208229158 mirMAP -0.261525269946054 0.000836905751890337 NA NA NA hsa-miR-107 MEF2C 0.658676029898313 5.11480446318819e-07 -0.861737319401213 4.52234474023972e-05 miRanda -0.324178093729088 1.38689949970375e-05 NA NA NA hsa-miR-10a-3p MEF2C 0.162369964979749 0.621747296513628 -0.861737319401213 4.52234474023972e-05 miRNATAP -0.10074973219156 0.00673762356793428 NA NA NA hsa-miR-130b-5p MEF2C 1.53645187062942 1.10498816261505e-08 -0.861737319401213 4.52234474023972e-05 MirTarget;miRNATAP -0.205555711625721 6.36719532944899e-09 NA NA NA hsa-miR-182-5p MEF2C 3.21839823004635 5.13049145201115e-39 -0.861737319401213 4.52234474023972e-05 MirTarget;miRNATAP -0.159760729569718 1.07656659620182e-05 NA NA NA hsa-miR-183-5p MEF2C 2.39247234736657 3.92444525331999e-21 -0.861737319401213 4.52234474023972e-05 MirTarget;miRNATAP -0.205461233492579 1.82525484574272e-08 NA NA NA hsa-miR-186-5p MEF2C 0.852175445703945 6.88885738584309e-10 -0.861737319401213 4.52234474023972e-05 miRNATAP -0.297748557602902 2.23248847942603e-05 NA NA NA hsa-miR-18a-5p MEF2C 1.37435209536521 9.2173853686829e-06 -0.861737319401213 4.52234474023972e-05 MirTarget -0.343419119012219 1.22222699806563e-26 NA NA NA hsa-miR-194-5p MEF2C 1.76979641760284 8.2064222072696e-05 -0.861737319401213 4.52234474023972e-05 miRNATAP -0.125520456446742 3.77755083399058e-09 NA NA NA hsa-miR-19a-3p MEF2C 2.11776595911517 7.07663078397156e-10 -0.861737319401213 4.52234474023972e-05 miRNATAP -0.271229067822073 5.29311000524074e-17 NA NA NA hsa-miR-19b-3p MEF2C 2.10868505662119 5.40846613768389e-17 -0.861737319401213 4.52234474023972e-05 miRNATAP -0.260544875340801 2.10958475308327e-11 NA NA NA hsa-miR-200c-5p MEF2C 1.7188514281688 1.38603090488265e-12 -0.861737319401213 4.52234474023972e-05 MirTarget -0.323870334402584 2.22503835171051e-17 NA NA NA hsa-miR-203a-3p MEF2C 1.06866854356847 0.00389979689199624 -0.861737319401213 4.52234474023972e-05 MirTarget -0.116866205991513 7.99588109556516e-06 NA NA NA hsa-miR-21-5p MEF2C 4.38165933891779 1.52536633902505e-92 -0.861737319401213 4.52234474023972e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.139612775050524 0.000172416351408651 NA NA NA hsa-miR-22-5p MEF2C 1.71436244278242 9.85038001236064e-15 -0.861737319401213 4.52234474023972e-05 MirTarget -0.20714140703427 1.2239744324896e-06 NA NA NA hsa-miR-2355-5p MEF2C 1.86174980095465 3.47492783095613e-13 -0.861737319401213 4.52234474023972e-05 MirTarget -0.250639429143795 3.14742086174905e-10 NA NA NA hsa-miR-26b-5p MEF2C 0.72362441215247 4.7794659748036e-05 -0.861737319401213 4.52234474023972e-05 miRNAWalker2_validate;miRNATAP -0.150785921105027 0.00615917021747558 NA NA NA hsa-miR-320b MEF2C 0.226640952564488 0.378818692487242 -0.861737319401213 4.52234474023972e-05 miRanda -0.174194407570877 4.20948113759865e-06 NA NA NA hsa-miR-324-3p MEF2C -0.0774700133118458 0.689226297032231 -0.861737319401213 4.52234474023972e-05 miRNATAP -0.225596249848847 8.2314656536482e-06 NA NA NA hsa-miR-331-5p MEF2C 0.578237334664505 0.00131211239210882 -0.861737319401213 4.52234474023972e-05 PITA -0.333255650972315 1.57013083111085e-09 NA NA NA hsa-miR-335-3p MEF2C 1.51116383169018 6.88553098788624e-13 -0.861737319401213 4.52234474023972e-05 MirTarget;mirMAP -0.212761932070364 2.51143055367659e-06 NA NA NA hsa-miR-421 MEF2C 0.170525317701774 0.535277026680289 -0.861737319401213 4.52234474023972e-05 PITA;miRanda;miRNATAP -0.2475079643524 8.03678707335723e-11 NA NA NA hsa-miR-425-5p MEF2C 1.21659524959201 8.01126418494715e-09 -0.861737319401213 4.52234474023972e-05 MirTarget;miRNATAP -0.414347694858663 4.30708897705358e-21 NA NA NA hsa-miR-429 MEF2C 2.3794516574089 1.72813419703734e-13 -0.861737319401213 4.52234474023972e-05 miRanda;miRNATAP -0.130691108870349 4.09777420802258e-05 NA NA NA hsa-miR-550a-3p MEF2C 0.0186193291188046 0.949896722138275 -0.861737319401213 4.52234474023972e-05 MirTarget -0.268334732925055 6.11808745824197e-16 NA NA NA hsa-miR-590-3p MEF2C 0.83851360565783 0.00129224433453587 -0.861737319401213 4.52234474023972e-05 mirMAP -0.21010846570223 2.53998328753048e-06 NA NA NA hsa-miR-590-5p MEF2C 2.07441240363458 4.95240551694843e-14 -0.861737319401213 4.52234474023972e-05 MirTarget;PITA;miRanda;miRNATAP -0.36726305386474 7.50375879303063e-19 NA NA NA hsa-miR-7-1-3p MEF2C 2.61364240402652 1.98959237815786e-32 -0.861737319401213 4.52234474023972e-05 MirTarget;mirMAP -0.288444702692305 1.75369631618883e-11 NA NA NA hsa-miR-744-3p MEF2C 2.07439104592565 3.30645434602132e-12 -0.861737319401213 4.52234474023972e-05 MirTarget;miRNATAP -0.181263854077031 1.05451320860282e-08 NA NA NA hsa-miR-9-5p MEF2C 4.99250901331516 2.59132733422801e-19 -0.861737319401213 4.52234474023972e-05 MirTarget;miRNATAP -0.120933812278151 2.10238417166847e-13 NA NA NA hsa-miR-92a-3p MEF2C -0.136362762339122 0.493412263619364 -0.861737319401213 4.52234474023972e-05 miRNAWalker2_validate -0.267478410366303 4.59318541274631e-08 NA NA NA hsa-miR-96-5p MEF2C 3.0381097138467 4.40362891630201e-24 -0.861737319401213 4.52234474023972e-05 miRNATAP -0.25750352193331 1.65339962554364e-13 NA NA NA hsa-miR-106b-5p MKNK2 1.47447672652218 1.32004094930462e-13 -0.59344427485427 3.78483081819925e-05 MirTarget;miRNATAP -0.131504264215692 5.44757267083166e-05 NA NA NA hsa-miR-128-3p MKNK2 1.03509868349735 2.11606310588315e-10 -0.59344427485427 3.78483081819925e-05 miRNAWalker2_validate -0.211208859610128 1.34718585325892e-07 NA NA NA hsa-miR-335-5p MKNK2 -0.466533891325811 0.0676987038122831 -0.59344427485427 3.78483081819925e-05 miRNAWalker2_validate -0.104000822898997 0.000367499744890637 NA NA NA hsa-miR-590-3p MKNK2 0.83851360565783 0.00129224433453587 -0.59344427485427 3.78483081819925e-05 miRanda -0.105359182005568 0.000567146263436042 NA NA NA hsa-miR-98-5p MKNK2 1.170602085804 1.09900501665229e-08 -0.59344427485427 3.78483081819925e-05 miRNAWalker2_validate -0.154200247233919 2.55320697230896e-06 NA NA NA hsa-miR-135b-5p MRAS 3.25019233805845 1.95560099639034e-15 -1.26981042312752 2.25317279900632e-13 miRNATAP -0.126854161321085 8.1015479639163e-10 NA NA NA hsa-miR-182-5p MRAS 3.21839823004635 5.13049145201115e-39 -1.26981042312752 2.25317279900632e-13 miRNATAP -0.217367608565938 2.91641159096101e-13 NA NA NA hsa-miR-29b-3p MRAS 3.10527711861309 3.01242507282711e-32 -1.26981042312752 2.25317279900632e-13 mirMAP -0.107073014365824 0.000217065105807304 NA NA NA hsa-miR-324-5p MRAS 1.06955541886548 5.39722006604758e-05 -1.26981042312752 2.25317279900632e-13 miRanda -0.119444531077426 9.39636460614906e-05 NA NA NA hsa-miR-335-3p MRAS 1.51116383169018 6.88553098788624e-13 -1.26981042312752 2.25317279900632e-13 mirMAP -0.22409253609703 2.25863619602441e-09 NA NA NA hsa-miR-429 MRAS 2.3794516574089 1.72813419703734e-13 -1.26981042312752 2.25317279900632e-13 miRanda;miRNATAP -0.18614468940234 1.07502040516879e-12 NA NA NA hsa-miR-582-5p MRAS 1.08286181406653 0.00149040450161757 -1.26981042312752 2.25317279900632e-13 mirMAP -0.10905516124636 7.5406825441415e-06 NA NA NA hsa-miR-7-1-3p MRAS 2.61364240402652 1.98959237815786e-32 -1.26981042312752 2.25317279900632e-13 mirMAP -0.151233200906711 3.1959019331961e-05 NA NA NA hsa-miR-96-5p MRAS 3.0381097138467 4.40362891630201e-24 -1.26981042312752 2.25317279900632e-13 TargetScan;miRNATAP -0.176216903551529 2.20276024331134e-09 NA NA NA hsa-miR-34a-5p MYC 1.40588612517769 8.60097477768592e-12 -0.594211476201249 0.0196490384548933 miRNAWalker2_validate;miRTarBase -0.160523406918217 0.0041257772904121 25572695;25686834;21460242;22159222;23640973;22830357;22235332 The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;miR 34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c Myc pathway;Myc mediated repression of microRNA 34a promotes high grade transformation of B cell lymphoma by dysregulation of FoxP1;MicroRNA 34a suppresses malignant transformation by targeting c Myc transcriptional complexes in human renal cell carcinoma; We investigated the functional effects of microRNA-34a miR-34a on c-Myc transcriptional complexes in renal cell carcinoma; miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region which was revealed by luciferase reporter assays; Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription indicating a novel role of miR-34a in the regulation of transcription by c-Myc;Among them miR-34a was also associated with poor prognosis in 2 independent series of leukemic and nodal MCL and in cooperation with high expression of the MYC oncogene;We report that miR-34a did not inhibit cell proliferation notwithstanding a marked down-regulation of c-MYC;MicroRNA 34a modulates c Myc transcriptional complexes to suppress malignancy in human prostate cancer cells; We studied the functional effects of miR-34a on c-Myc transcriptional complexes in PC-3 prostate cancer cells; miR-34a downregulated expression of c-Myc oncogene by targeting its 3' UTR as shown by luciferase reporter assays; This is the first report to document that miR-34a suppresses assembly and function of the c-Myc-Skp2-Miz1 complex that activates RhoA and the c-Myc-pTEFB complex that elongates transcription of various genes suggesting a novel role of miR-34a in the regulation of transcription by c-Myc complex ;;;malignant trasformation;worse prognosis;; bladder cancer;liver cancer;B cell lymphoma;kidney renal cell cancer;lymphoma;lymphoma;prostate cancer hsa-miR-429 MYC 2.3794516574089 1.72813419703734e-13 -0.594211476201249 0.0196490384548933 miRNAWalker2_validate -0.178099724014789 2.94573429210347e-06 21684154;24633485 miR 429 modulates the expression of c myc in human gastric carcinoma cells; SGC-7901 gastric cancer cells were transfected with miR-429 mimics and endogenous c-myc expression was detected by western blots; We performed functional assays using the 3'UTR of the c-myc gene as a miR-429 target in a luciferase reporter assay system; miR-429 significantly downregulated endogenous c-myc expression in SGC-7901 cells; Action of miR/429 on c-myc 3'UTR was confirmed; c-myc is an important miR-429 target gene;It is known that miR-429 is down-regulated and functions as a tumor suppressor by targeting c-myc and PLGG1 in gastric and breast cancer ; gastric cancer;sarcoma hsa-miR-101-5p NF1 -0.0265235292039296 0.917878791358577 0.337750472021996 0.0168165069319537 MirTarget -0.14893967812297 1.96946584883157e-06 NA NA NA hsa-miR-195-5p NF1 -1.01577502605386 4.80814718341729e-05 0.337750472021996 0.0168165069319537 MirTarget -0.112894686236858 3.19944876113706e-05 NA NA NA hsa-miR-30c-5p NF1 -0.327319105755825 0.123595832152687 0.337750472021996 0.0168165069319537 MirTarget;mirMAP;miRNATAP -0.146273545917688 1.57100996298072e-06 NA NA NA hsa-miR-497-5p NF1 -0.0546347378264729 0.786205564901684 0.337750472021996 0.0168165069319537 MirTarget -0.113921993428693 0.000437659700777723 NA NA NA hsa-miR-590-3p NF1 0.83851360565783 0.00129224433453587 0.337750472021996 0.0168165069319537 MirTarget;PITA;miRanda;miRNATAP -0.106794316707531 0.000336101204223692 NA NA NA hsa-miR-130b-5p NFATC2 1.53645187062942 1.10498816261505e-08 -1.17929519652878 0.000402858371584528 MirTarget -0.172861973245698 0.00221822037960357 NA NA NA hsa-miR-182-5p NFATC2 3.21839823004635 5.13049145201115e-39 -1.17929519652878 0.000402858371584528 mirMAP -0.180422957533554 0.00169761028088969 NA NA NA hsa-miR-185-5p NFATC2 1.14291034858482 2.95777119743491e-13 -1.17929519652878 0.000402858371584528 MirTarget -0.360674698099435 0.00018867412489729 NA NA NA hsa-miR-186-5p NFATC2 0.852175445703945 6.88885738584309e-10 -1.17929519652878 0.000402858371584528 mirMAP -0.343079979359603 0.00202223937894896 NA NA NA hsa-miR-19a-3p NFATC2 2.11776595911517 7.07663078397156e-10 -1.17929519652878 0.000402858371584528 mirMAP -0.336569537886002 7.83772096103092e-11 NA NA NA hsa-miR-19b-3p NFATC2 2.10868505662119 5.40846613768389e-17 -1.17929519652878 0.000402858371584528 mirMAP -0.37856857138205 7.5498987798628e-10 NA NA NA hsa-miR-2355-3p NFATC2 1.10676344164715 6.24068383465151e-06 -1.17929519652878 0.000402858371584528 mirMAP -0.219356663156956 0.000875934214021124 NA NA NA hsa-miR-29a-5p NFATC2 1.89519956688438 1.03453349363915e-11 -1.17929519652878 0.000402858371584528 mirMAP;miRNATAP -0.177982407502831 0.00605902966456155 NA NA NA hsa-miR-30b-5p NFATC2 0.358144314839612 0.138026229059594 -1.17929519652878 0.000402858371584528 MirTarget;mirMAP -0.200783588972738 0.00170730601229697 NA NA NA hsa-miR-3613-5p NFATC2 0.0237159233591191 0.934730899070298 -1.17929519652878 0.000402858371584528 mirMAP -0.24336416775385 0.000133096294572765 NA NA NA hsa-miR-590-3p NFATC2 0.83851360565783 0.00129224433453587 -1.17929519652878 0.000402858371584528 mirMAP -0.264991647100287 0.000176914211247844 NA NA NA hsa-miR-9-5p NFATC2 4.99250901331516 2.59132733422801e-19 -1.17929519652878 0.000402858371584528 MirTarget -0.105804655043001 6.44752588454657e-05 NA NA NA hsa-miR-185-3p NFATC4 -0.377490365509078 0.093653288903368 0.936688963651323 2.59723598381625e-05 MirTarget -0.154954243253114 0.00074408877001007 NA NA NA hsa-miR-423-5p NFATC4 -1.80309342242719 1.34791344187441e-19 0.936688963651323 2.59723598381625e-05 miRNATAP -0.21075464541514 2.27046521867108e-05 NA NA NA hsa-miR-671-5p NFKB1 2.24156654191798 2.10433241567652e-14 -0.340270335589995 0.00609383891055805 MirTarget -0.104865468815509 3.02257267140541e-06 NA NA NA hsa-miR-98-5p NFKB2 1.170602085804 1.09900501665229e-08 0.284604519142148 0.0589937439377632 miRNAWalker2_validate -0.112942136591414 0.00098350385065823 NA NA NA hsa-let-7a-5p NLK -1.37014061604018 3.11451492971224e-14 0.200178958380761 0.0535794568700787 TargetScan;miRNATAP -0.103621418358745 5.33089533473749e-05 NA NA NA hsa-let-7i-5p NLK 0.605080599172936 1.48406814653206e-06 0.200178958380761 0.0535794568700787 miRNATAP -0.112522534494759 0.00313058994702316 NA NA NA hsa-miR-140-5p NLK 0.669142684153918 0.000335928403032308 0.200178958380761 0.0535794568700787 MirTarget;PITA;miRanda;miRNATAP -0.112541275204177 1.52265042518288e-05 NA NA NA hsa-miR-181a-5p NLK -0.375429731222937 0.0562142867129802 0.200178958380761 0.0535794568700787 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.107008850019333 9.28298383191624e-06 NA NA NA hsa-miR-221-3p NLK -0.0986794612964683 0.654454148658401 0.200178958380761 0.0535794568700787 MirTarget;miRNATAP -0.115643852898254 6.68410917475072e-08 NA NA NA hsa-miR-222-3p NLK 0.0327210697409583 0.881937768109611 0.200178958380761 0.0535794568700787 MirTarget;miRNATAP -0.102916697650006 1.70487392395318e-06 NA NA NA hsa-miR-23a-3p NLK 0.111958289789488 0.393086414480463 0.200178958380761 0.0535794568700787 miRNAWalker2_validate;MirTarget -0.191900459374887 1.50088805987341e-07 NA NA NA hsa-miR-23b-3p NLK -0.070273068040148 0.620585267977425 0.200178958380761 0.0535794568700787 MirTarget -0.112998955682267 0.000870007705681694 NA NA NA hsa-miR-24-3p NLK -0.0357874587555003 0.785865078836504 0.200178958380761 0.0535794568700787 miRNATAP -0.122312627889454 0.000856037623694819 NA NA NA hsa-miR-26a-5p NLK -0.126411409001078 0.440028840408711 0.200178958380761 0.0535794568700787 miRNATAP -0.110559225376151 0.000156249291102499 NA NA NA hsa-miR-27a-3p NLK 0.433402568013802 0.00737164631768323 0.200178958380761 0.0535794568700787 miRNATAP -0.141087739477666 1.54945037774992e-06 NA NA NA hsa-miR-27b-3p NLK 0.236438984240408 0.12263510345883 0.200178958380761 0.0535794568700787 miRNATAP -0.117627767819408 0.000170454257441477 NA NA NA hsa-miR-361-5p NR4A1 0.21454431962475 0.0800957579368424 -2.14549816305305 6.87814315982894e-09 miRanda -0.444578377340064 0.00204617196369179 NA NA NA hsa-miR-542-3p NR4A1 1.62226640768239 2.6427102465476e-10 -2.14549816305305 6.87814315982894e-09 PITA;miRanda -0.330110609836865 5.06420443022426e-07 NA NA NA hsa-miR-145-5p NRAS -1.34926078156437 2.63526538800669e-07 0.110922789912811 0.412920190999736 miRNAWalker2_validate;MirTarget;miRNATAP -0.142760374746012 6.05977027346954e-10 26973415 miR-145 expression was significantly downregulated in colon cancer tissues with its expression in normal colonic tissues being 4-5-fold higher two sample t test P < 0.05 whereas N-ras expression showed the opposite trend colon cancer hsa-miR-148a-3p NRAS 2.30885799126944 1.95226081368985e-21 0.110922789912811 0.412920190999736 MirTarget -0.109343012733505 6.98144190286614e-06 NA NA NA hsa-miR-195-3p NRAS -1.33068822339418 6.65427393047357e-09 0.110922789912811 0.412920190999736 mirMAP -0.160994991063139 1.05944502094987e-09 NA NA NA hsa-miR-22-3p NRAS 1.42501909916631 1.72295005910055e-25 0.110922789912811 0.412920190999736 MirTarget;miRNATAP -0.128848632159027 0.00314401368706814 NA NA NA hsa-miR-26b-5p NRAS 0.72362441215247 4.7794659748036e-05 0.110922789912811 0.412920190999736 mirMAP;miRNATAP -0.130094780209659 0.000185700963505737 NA NA NA hsa-miR-27b-3p NRAS 0.236438984240408 0.12263510345883 0.110922789912811 0.412920190999736 miRNATAP -0.154582178613336 0.000157756473886806 NA NA NA hsa-miR-29a-3p NRAS 0.101650412194573 0.573201097011668 0.110922789912811 0.412920190999736 miRNATAP -0.156058827596967 6.08074898827527e-06 NA NA NA hsa-miR-29b-3p NRAS 3.10527711861309 3.01242507282711e-32 0.110922789912811 0.412920190999736 miRNATAP -0.130094390329954 2.14950403130123e-09 NA NA NA hsa-miR-29c-3p NRAS 1.32354490728858 1.84279305179762e-07 0.110922789912811 0.412920190999736 miRNATAP -0.132620598651339 2.93062944029642e-08 NA NA NA hsa-miR-320a NRAS -0.961144925954715 1.62478794429204e-08 0.110922789912811 0.412920190999736 mirMAP -0.138653847620251 0.000123789780187142 NA NA NA hsa-miR-502-3p NRAS -0.262270070977708 0.161760375279961 0.110922789912811 0.412920190999736 MirTarget -0.116067692488029 0.000491333225482351 NA NA NA hsa-miR-664a-3p NRAS 0.443077463053857 0.0214248925850984 0.110922789912811 0.412920190999736 MirTarget -0.339669060778621 8.1321923374988e-29 NA NA NA hsa-miR-142-3p NTF3 3.98476449801341 1.56256182021111e-35 -1.21316884460928 0.000957794321386974 miRanda -0.132391088121297 0.00694622430224727 NA NA NA hsa-miR-200c-3p NTF3 0.380533388300368 0.0842181838538353 -1.21316884460928 0.000957794321386974 miRNAWalker2_validate;miRNATAP -0.208337360877354 0.00711208431360534 NA NA NA hsa-miR-21-5p NTF3 4.38165933891779 1.52536633902505e-92 -1.21316884460928 0.000957794321386974 miRTarBase;miRNATAP -0.277170192916863 1.64786275260932e-05 NA NA NA hsa-miR-590-3p NTF3 0.83851360565783 0.00129224433453587 -1.21316884460928 0.000957794321386974 miRanda -0.251401735860011 0.00126362075034438 NA NA NA hsa-miR-185-3p NTRK1 -0.377490365509078 0.093653288903368 -1.20191019732804 0.000181518709629851 MirTarget -0.220344116634979 0.000867618792014595 NA NA NA hsa-miR-130b-3p NTRK2 1.83046548750752 5.04753914574694e-13 -2.56364615593132 1.62911334525602e-08 mirMAP -0.588115812319922 3.25886271258664e-12 NA NA NA hsa-miR-130b-5p NTRK2 1.53645187062942 1.10498816261505e-08 -2.56364615593132 1.62911334525602e-08 mirMAP -0.447056548884639 5.74660614017045e-09 NA NA NA hsa-miR-151a-5p NTRK2 1.23124135275661 2.93488020257558e-12 -2.56364615593132 1.62911334525602e-08 miRNATAP -0.404254240257679 0.000623285412545112 NA NA NA hsa-miR-15b-3p NTRK2 0.804736041893915 0.000400279611457186 -2.56364615593132 1.62911334525602e-08 mirMAP -0.277740657056852 0.00473888405637355 NA NA NA hsa-miR-17-3p NTRK2 1.36706429551147 4.60388403547821e-13 -2.56364615593132 1.62911334525602e-08 miRNATAP -0.462037732826128 2.48808237203963e-05 NA NA NA hsa-miR-182-5p NTRK2 3.21839823004635 5.13049145201115e-39 -2.56364615593132 1.62911334525602e-08 mirMAP -0.395114751858306 4.77623924189024e-07 NA NA NA hsa-miR-20a-3p NTRK2 2.51803599558247 4.92479325298629e-13 -2.56364615593132 1.62911334525602e-08 mirMAP -0.364998835563012 1.65748631141832e-06 NA NA NA hsa-miR-21-5p NTRK2 4.38165933891779 1.52536633902505e-92 -2.56364615593132 1.62911334525602e-08 mirMAP -0.470648222362519 3.55420725351027e-09 NA NA NA hsa-miR-29a-5p NTRK2 1.89519956688438 1.03453349363915e-11 -2.56364615593132 1.62911334525602e-08 mirMAP -0.345867869966745 9.99636115678843e-05 NA NA NA hsa-miR-301a-3p NTRK2 2.70198002906399 1.56420889710984e-14 -2.56364615593132 1.62911334525602e-08 mirMAP -0.357966104712284 6.80841814025626e-07 NA NA NA hsa-miR-320b NTRK2 0.226640952564488 0.378818692487242 -2.56364615593132 1.62911334525602e-08 mirMAP -0.286044846597318 0.000526912439992569 NA NA NA hsa-miR-335-3p NTRK2 1.51116383169018 6.88553098788624e-13 -2.56364615593132 1.62911334525602e-08 mirMAP -0.559361058530472 9.51509422827442e-09 NA NA NA hsa-miR-421 NTRK2 0.170525317701774 0.535277026680289 -2.56364615593132 1.62911334525602e-08 mirMAP -0.304690560726909 0.0002799728683427 NA NA NA hsa-miR-454-3p NTRK2 1.49453641052169 4.46235742871434e-09 -2.56364615593132 1.62911334525602e-08 mirMAP -0.333749932009109 0.000672846540177429 NA NA NA hsa-miR-576-5p NTRK2 1.02693643167056 1.14846964470173e-06 -2.56364615593132 1.62911334525602e-08 PITA;mirMAP -0.37738321255992 0.000150408264625595 NA NA NA hsa-miR-590-3p NTRK2 0.83851360565783 0.00129224433453587 -2.56364615593132 1.62911334525602e-08 PITA;miRanda;mirMAP -0.392514341110474 5.33682930755441e-05 NA NA NA hsa-miR-590-5p NTRK2 2.07441240363458 4.95240551694843e-14 -2.56364615593132 1.62911334525602e-08 miRanda;mirMAP -0.40715451036762 1.11592186360866e-05 NA NA NA hsa-miR-30c-2-3p PAK1 -3.10905250533941 6.84550165664783e-27 1.08615212555614 2.32491055448077e-14 MirTarget -0.154051600518757 6.58939241738245e-13 NA NA NA hsa-miR-342-3p PAK1 -0.128691966564961 0.561034080130801 1.08615212555614 2.32491055448077e-14 miRanda -0.11605740701123 0.000138325198264815 NA NA NA hsa-miR-186-5p PAK2 0.852175445703945 6.88885738584309e-10 -0.164896023734459 0.153652182388238 MirTarget -0.153349441471628 5.49359290719855e-05 NA NA NA hsa-miR-23b-3p PAK2 -0.070273068040148 0.620585267977425 -0.164896023734459 0.153652182388238 MirTarget -0.100289131217277 0.00816893039950937 NA NA NA hsa-miR-26b-5p PAK2 0.72362441215247 4.7794659748036e-05 -0.164896023734459 0.153652182388238 MirTarget;mirMAP;miRNATAP -0.173530495671578 3.35032912896637e-09 NA NA NA hsa-miR-29a-5p PAK2 1.89519956688438 1.03453349363915e-11 -0.164896023734459 0.153652182388238 mirMAP -0.119436627795289 5.70800029435606e-08 NA NA NA hsa-miR-455-5p PAK2 1.36946341828134 5.05118627562807e-08 -0.164896023734459 0.153652182388238 miRanda -0.109807631196541 4.38250829825112e-06 NA NA NA hsa-miR-335-3p PDGFA 1.51116383169018 6.88553098788624e-13 -1.02357928315978 6.32690913682403e-05 mirMAP -0.248081383651425 5.98335990526186e-06 NA NA NA hsa-miR-421 PDGFA 0.170525317701774 0.535277026680289 -1.02357928315978 6.32690913682403e-05 miRanda -0.246541712884684 1.12589234652839e-07 NA NA NA hsa-miR-576-5p PDGFA 1.02693643167056 1.14846964470173e-06 -1.02357928315978 6.32690913682403e-05 mirMAP -0.200616922001446 0.000312414801468213 NA NA NA hsa-miR-590-3p PDGFA 0.83851360565783 0.00129224433453587 -1.02357928315978 6.32690913682403e-05 miRanda -0.159499365763311 0.00342016098327547 NA NA NA hsa-miR-590-5p PDGFA 2.07441240363458 4.95240551694843e-14 -1.02357928315978 6.32690913682403e-05 miRanda -0.168569970910494 0.00119006900103511 NA NA NA hsa-let-7f-5p PDGFB -0.0523311272618407 0.83407808268787 -1.57245721400853 2.64510689458541e-14 miRNATAP -0.111940449788439 0.00438563718329827 NA NA NA hsa-miR-17-5p PDGFB 2.07078488653279 2.77403038572568e-19 -1.57245721400853 2.64510689458541e-14 TargetScan -0.128759642118731 0.00159228819466453 NA NA NA hsa-miR-29b-3p PDGFB 3.10527711861309 3.01242507282711e-32 -1.57245721400853 2.64510689458541e-14 MirTarget;miRNATAP -0.163569333467524 2.06968288487126e-06 NA NA NA hsa-miR-29c-3p PDGFB 1.32354490728858 1.84279305179762e-07 -1.57245721400853 2.64510689458541e-14 MirTarget;miRNATAP -0.160756497303994 2.23137768074853e-05 NA NA NA hsa-let-7g-3p PDGFRA 2.38336858943031 4.8771148585792e-17 -0.920353534269053 0.00039437071007992 MirTarget;miRNATAP -0.123737451095322 0.00243922499879256 NA NA NA hsa-miR-106a-5p PDGFRA 1.3902608059488 6.07931522284525e-05 -0.920353534269053 0.00039437071007992 MirTarget;miRNATAP -0.262061462129381 3.43080881453501e-12 NA NA NA hsa-miR-106b-5p PDGFRA 1.47447672652218 1.32004094930462e-13 -0.920353534269053 0.00039437071007992 MirTarget;miRNATAP -0.437339015207479 2.74054790375275e-14 NA NA NA hsa-miR-130b-3p PDGFRA 1.83046548750752 5.04753914574694e-13 -0.920353534269053 0.00039437071007992 MirTarget;miRNATAP -0.228770191152218 2.33154390281087e-06 NA NA NA hsa-miR-141-3p PDGFRA 3.36993755486106 5.42939251147195e-32 -0.920353534269053 0.00039437071007992 MirTarget -0.32772250053676 4.14560711921769e-18 NA NA NA hsa-miR-16-1-3p PDGFRA 1.50034693398929 6.63958242991125e-10 -0.920353534269053 0.00039437071007992 MirTarget -0.392102224483284 4.01359006065225e-11 NA NA NA hsa-miR-17-5p PDGFRA 2.07078488653279 2.77403038572568e-19 -0.920353534269053 0.00039437071007992 MirTarget;TargetScan;miRNATAP -0.437831726557654 1.09121275373163e-19 NA NA NA hsa-miR-181b-5p PDGFRA 0.668793269169928 0.000239998092406404 -0.920353534269053 0.00039437071007992 MirTarget;miRNATAP -0.243346668635648 0.000221056637302438 NA NA NA hsa-miR-182-5p PDGFRA 3.21839823004635 5.13049145201115e-39 -0.920353534269053 0.00039437071007992 miRNATAP -0.228069978604342 2.76628203495785e-07 NA NA NA hsa-miR-186-5p PDGFRA 0.852175445703945 6.88885738584309e-10 -0.920353534269053 0.00039437071007992 MirTarget -0.444642699585465 2.17102227065078e-07 NA NA NA hsa-miR-200a-3p PDGFRA 3.14766878548496 1.32850889777422e-21 -0.920353534269053 0.00039437071007992 MirTarget -0.223485348461317 1.8870643178893e-10 NA NA NA hsa-miR-20a-5p PDGFRA 2.64649625616975 5.1469418982085e-27 -0.920353534269053 0.00039437071007992 MirTarget;miRNATAP -0.375839309283569 3.9000709448395e-17 NA NA NA hsa-miR-20b-5p PDGFRA 1.35770573270947 0.00260808530013016 -0.920353534269053 0.00039437071007992 MirTarget;miRNATAP -0.125923024866371 5.86457189774267e-06 NA NA NA hsa-miR-26b-5p PDGFRA 0.72362441215247 4.7794659748036e-05 -0.920353534269053 0.00039437071007992 miRNAWalker2_validate;MirTarget;mirMAP;miRNATAP -0.299986293654127 7.81964761899525e-06 NA NA NA hsa-miR-29b-1-5p PDGFRA 1.71024742617744 3.64915691793611e-09 -0.920353534269053 0.00039437071007992 mirMAP -0.203385697475619 4.80726047062849e-07 NA NA NA hsa-miR-29b-3p PDGFRA 3.10527711861309 3.01242507282711e-32 -0.920353534269053 0.00039437071007992 MirTarget -0.210988079915463 6.03805137676526e-07 NA NA NA hsa-miR-301a-3p PDGFRA 2.70198002906399 1.56420889710984e-14 -0.920353534269053 0.00039437071007992 MirTarget;miRNATAP -0.242329454445345 2.28119446181804e-09 NA NA NA hsa-miR-3065-5p PDGFRA 0.653308707552535 0.0999497219778851 -0.920353534269053 0.00039437071007992 mirMAP -0.145680616077162 8.34288503273181e-06 NA NA NA hsa-miR-335-3p PDGFRA 1.51116383169018 6.88553098788624e-13 -0.920353534269053 0.00039437071007992 mirMAP -0.345739811848265 3.1636014257612e-10 NA NA NA hsa-miR-338-3p PDGFRA 0.726843067232002 0.0506251324215494 -0.920353534269053 0.00039437071007992 miRanda -0.106588181578414 0.000936971496448231 NA NA NA hsa-miR-339-5p PDGFRA 0.536997313601114 0.0488090394176611 -0.920353534269053 0.00039437071007992 miRanda -0.191797874450638 1.22262689505586e-05 NA NA NA hsa-miR-33a-5p PDGFRA 2.80127809675219 5.09053890529424e-12 -0.920353534269053 0.00039437071007992 MirTarget;miRNATAP -0.207468703325488 4.3541979242939e-09 NA NA NA hsa-miR-34a-5p PDGFRA 1.40588612517769 8.60097477768592e-12 -0.920353534269053 0.00039437071007992 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.210491527503148 0.000228547067911926 22750848 Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network glioblastoma hsa-miR-362-3p PDGFRA 0.194097672030785 0.52808475179225 -0.920353534269053 0.00039437071007992 miRanda -0.195936237894039 5.79891842116764e-05 NA NA NA hsa-miR-421 PDGFRA 0.170525317701774 0.535277026680289 -0.920353534269053 0.00039437071007992 PITA;miRanda;miRNATAP -0.173891582150038 0.000247812525545878 NA NA NA hsa-miR-429 PDGFRA 2.3794516574089 1.72813419703734e-13 -0.920353534269053 0.00039437071007992 miRanda;miRNATAP -0.246006444903332 1.87540030422368e-10 NA NA NA hsa-miR-450b-5p PDGFRA 1.69248953402469 1.96052058003353e-07 -0.920353534269053 0.00039437071007992 mirMAP -0.122074687915198 0.00275129796040725 NA NA NA hsa-miR-454-3p PDGFRA 1.49453641052169 4.46235742871434e-09 -0.920353534269053 0.00039437071007992 MirTarget;miRNATAP -0.418333685525631 1.11010754867789e-14 NA NA NA hsa-miR-576-5p PDGFRA 1.02693643167056 1.14846964470173e-06 -0.920353534269053 0.00039437071007992 mirMAP -0.298051358520212 9.84291671920344e-08 NA NA NA hsa-miR-589-3p PDGFRA 1.34253876396688 1.84935927493927e-05 -0.920353534269053 0.00039437071007992 mirMAP -0.134517057854286 0.000597797805674663 NA NA NA hsa-miR-590-3p PDGFRA 0.83851360565783 0.00129224433453587 -0.920353534269053 0.00039437071007992 miRanda;mirMAP -0.215815523135662 8.72132841756153e-05 NA NA NA hsa-miR-590-5p PDGFRA 2.07441240363458 4.95240551694843e-14 -0.920353534269053 0.00039437071007992 miRanda -0.320495725599276 6.72663827937009e-10 NA NA NA hsa-miR-7-1-3p PDGFRA 2.61364240402652 1.98959237815786e-32 -0.920353534269053 0.00039437071007992 mirMAP -0.280823951585571 1.24689968872089e-07 NA NA NA hsa-miR-93-5p PDGFRA 1.50844106515467 1.83836866996875e-12 -0.920353534269053 0.00039437071007992 MirTarget;miRNATAP -0.429749525450464 7.91013052237628e-16 NA NA NA hsa-miR-96-5p PDGFRA 3.0381097138467 4.40362891630201e-24 -0.920353534269053 0.00039437071007992 TargetScan;miRNATAP -0.313559555428942 2.60827207243362e-13 NA NA NA hsa-miR-29b-3p PDGFRB 3.10527711861309 3.01242507282711e-32 -0.472627234019869 0.0195049282675806 miRNATAP -0.101003962314959 0.00225724349565461 NA NA NA hsa-miR-3127-5p PDGFRB 0.382717393698386 0.11535780874721 -0.472627234019869 0.0195049282675806 mirMAP -0.153147342374875 6.32703967379545e-05 NA NA NA hsa-miR-421 PDGFRB 0.170525317701774 0.535277026680289 -0.472627234019869 0.0195049282675806 miRanda -0.182914387101734 5.73372143884839e-07 NA NA NA hsa-miR-142-5p PLA2G12A 1.29672439149353 4.0768822158894e-06 -0.0788546181881973 0.499158564786441 mirMAP -0.131800396566356 4.84970998647658e-11 NA NA NA hsa-miR-150-5p PLA2G12A -0.702328520623782 0.0215316651134431 -0.0788546181881973 0.499158564786441 mirMAP -0.109476263552952 1.80094060108042e-10 NA NA NA hsa-miR-28-5p PLA2G1B 1.19639196514745 4.59365801666536e-18 -4.65869434494303 5.92632211074147e-12 miRanda -0.714163430019852 0.00154176723606543 NA NA NA hsa-miR-1976 PLA2G2F -1.27772236648866 7.13245221784788e-10 1.85239250918301 0.000408421370733288 mirMAP -0.412433519219505 0.000339748244121928 NA NA NA hsa-miR-532-5p PLA2G2F 0.576620898517708 0.0023245812680956 1.85239250918301 0.000408421370733288 mirMAP -0.384692781015398 0.00274632142999211 NA NA NA hsa-miR-450b-5p PLA2G3 1.69248953402469 1.96052058003353e-07 -3.26398420302921 7.81993892455061e-08 miRNATAP -0.430421579056939 6.90748646882128e-06 NA NA NA hsa-miR-452-3p PLA2G3 0.477736876273128 0.22218404598603 -3.26398420302921 7.81993892455061e-08 MirTarget -0.255221077598253 0.00248457917549569 NA NA NA hsa-miR-146b-5p PLA2G4A 1.0922867893808 5.63754607494775e-06 1.23139708452911 0.00360064815222154 miRNAWalker2_validate -0.539646016767087 8.49384554342977e-12 NA NA NA hsa-miR-30a-5p PLA2G4A -0.924084264430689 0.000762030454634728 1.23139708452911 0.00360064815222154 miRNAWalker2_validate -0.337988397444713 1.56392399647892e-06 NA NA NA hsa-miR-361-5p PLA2G4A 0.21454431962475 0.0800957579368424 1.23139708452911 0.00360064815222154 miRanda -0.455000317938252 0.005160776853399 NA NA NA hsa-miR-374a-5p PLA2G4A -0.197027254874826 0.298080902192861 1.23139708452911 0.00360064815222154 mirMAP -0.384602231876405 0.000945916552995376 NA NA NA hsa-miR-450b-5p PLA2G4E 1.69248953402469 1.96052058003353e-07 -0.723776164951995 0.201279307414008 mirMAP -0.353591315163214 6.01448410118293e-05 NA NA NA hsa-miR-128-3p PLA2G5 1.03509868349735 2.11606310588315e-10 -1.52854910719925 3.60899705613865e-08 miRNAWalker2_validate -0.463850459902729 2.23760548419397e-09 NA NA NA hsa-miR-330-5p PLA2G5 0.168520831101569 0.336433937906706 -1.52854910719925 3.60899705613865e-08 miRanda -0.308708237234084 3.20106460280176e-05 NA NA NA hsa-miR-429 PLA2G5 2.3794516574089 1.72813419703734e-13 -1.52854910719925 3.60899705613865e-08 miRanda -0.178077576146297 2.39509849764538e-05 NA NA NA hsa-miR-590-5p PLA2G5 2.07441240363458 4.95240551694843e-14 -1.52854910719925 3.60899705613865e-08 miRanda -0.21637478398772 0.000135984222229852 NA NA NA hsa-miR-185-3p PLA2G6 -0.377490365509078 0.093653288903368 0.476315859876846 0.0705352394789323 MirTarget -0.267493284551792 5.88524200603373e-07 NA NA NA hsa-miR-30a-3p PLA2G6 -2.54042202792785 2.9111625410859e-18 0.476315859876846 0.0705352394789323 miRNATAP -0.146668786631899 0.000240180915888741 NA NA NA hsa-miR-423-5p PLA2G6 -1.80309342242719 1.34791344187441e-19 0.476315859876846 0.0705352394789323 MirTarget;miRNATAP -0.232289362179402 7.11654533343099e-05 NA NA NA hsa-miR-140-3p PPM1A -1.11373309124537 8.35257079443689e-14 -0.10532002120943 0.305346670664136 miRNATAP -0.105126722476028 0.000678991840186864 NA NA NA hsa-miR-15a-5p PPM1A 1.62575353599172 1.55312121019827e-19 -0.10532002120943 0.305346670664136 MirTarget;miRNATAP -0.127839436208603 3.17810287398622e-07 NA NA NA hsa-miR-186-5p PPM1A 0.852175445703945 6.88885738584309e-10 -0.10532002120943 0.305346670664136 mirMAP;miRNATAP -0.122011847207173 0.000305672101418856 NA NA NA hsa-miR-23a-3p PPM1A 0.111958289789488 0.393086414480463 -0.10532002120943 0.305346670664136 mirMAP -0.162872921433864 7.16086898925253e-06 NA NA NA hsa-miR-34a-5p PPM1A 1.40588612517769 8.60097477768592e-12 -0.10532002120943 0.305346670664136 miRNATAP -0.144543974470979 4.9397569198317e-11 NA NA NA hsa-miR-181a-5p PPM1B -0.375429731222937 0.0562142867129802 -0.0875779378741743 0.325635282927335 mirMAP;miRNATAP -0.109806788562897 9.29957798647789e-08 NA NA NA hsa-miR-199a-5p PPM1B 1.3057193856884 2.38429382751645e-08 -0.0875779378741743 0.325635282927335 PITA;miRanda;miRNATAP -0.128201088008978 1.73369287804118e-14 NA NA NA hsa-miR-342-3p PPM1B -0.128691966564961 0.561034080130801 -0.0875779378741743 0.325635282927335 miRanda -0.124653959289283 5.36673857124639e-12 NA NA NA hsa-miR-106a-5p PPP3CA 1.3902608059488 6.07931522284525e-05 -0.313973239016408 0.0165177462343014 miRNATAP -0.133933104567234 1.19345709173472e-12 NA NA NA hsa-miR-142-3p PPP3CA 3.98476449801341 1.56256182021111e-35 -0.313973239016408 0.0165177462343014 miRNATAP -0.118826172048727 2.75854825586705e-12 NA NA NA hsa-miR-17-5p PPP3CA 2.07078488653279 2.77403038572568e-19 -0.313973239016408 0.0165177462343014 miRNATAP -0.176015588845375 7.62312188608765e-13 NA NA NA hsa-miR-186-5p PPP3CA 0.852175445703945 6.88885738584309e-10 -0.313973239016408 0.0165177462343014 mirMAP -0.286847992743368 1.57472937315132e-11 NA NA NA hsa-miR-20a-5p PPP3CA 2.64649625616975 5.1469418982085e-27 -0.313973239016408 0.0165177462343014 miRNATAP -0.154552998486965 9.11892644521842e-12 NA NA NA hsa-miR-20b-5p PPP3CA 1.35770573270947 0.00260808530013016 -0.313973239016408 0.0165177462343014 miRNATAP -0.122294666346707 1.15249428256532e-19 NA NA NA hsa-miR-30c-5p PPP3CA -0.327319105755825 0.123595832152687 -0.313973239016408 0.0165177462343014 miRNATAP -0.10873673306536 0.000125286600086868 NA NA NA hsa-miR-361-3p PPP3CA 0.0988926195529967 0.549128728500555 -0.313973239016408 0.0165177462343014 MirTarget;PITA;miRNATAP -0.173641727258806 2.07130127414673e-06 NA NA NA hsa-miR-501-3p PPP3CA -0.0405952693028064 0.866802243505833 -0.313973239016408 0.0165177462343014 MirTarget;PITA;miRNATAP -0.152231773192009 5.82453493976863e-10 NA NA NA hsa-miR-502-3p PPP3CA -0.262270070977708 0.161760375279961 -0.313973239016408 0.0165177462343014 MirTarget;PITA;miRNATAP -0.102225645893012 0.00155670003675052 NA NA NA hsa-miR-589-3p PPP3CA 1.34253876396688 1.84935927493927e-05 -0.313973239016408 0.0165177462343014 MirTarget -0.111512777165905 9.25189699847489e-09 NA NA NA hsa-miR-590-3p PPP3CA 0.83851360565783 0.00129224433453587 -0.313973239016408 0.0165177462343014 miRanda;mirMAP -0.108711400054004 7.97592745451833e-05 NA NA NA hsa-miR-590-5p PPP3CA 2.07441240363458 4.95240551694843e-14 -0.313973239016408 0.0165177462343014 PITA;miRanda;miRNATAP -0.177690930412641 6.75602594094779e-12 NA NA NA hsa-miR-7-1-3p PPP3CA 2.61364240402652 1.98959237815786e-32 -0.313973239016408 0.0165177462343014 MirTarget;mirMAP -0.121059394653456 5.88147588879243e-06 NA NA NA hsa-miR-93-3p PPP3CA 1.07631808403007 1.63747525692813e-05 -0.313973239016408 0.0165177462343014 miRNATAP -0.170128744194282 3.50156314525736e-13 NA NA NA hsa-miR-93-5p PPP3CA 1.50844106515467 1.83836866996875e-12 -0.313973239016408 0.0165177462343014 miRNATAP -0.25180151434334 1.28858993768457e-21 NA NA NA hsa-miR-15a-5p PPP3CB 1.62575353599172 1.55312121019827e-19 -0.217161149975175 0.026537796620393 miRNATAP -0.123109224513088 2.45320870406106e-07 NA NA NA hsa-miR-30c-5p PPP3CB -0.327319105755825 0.123595832152687 -0.217161149975175 0.026537796620393 miRNATAP -0.117562918064524 1.93721091880072e-08 NA NA NA hsa-miR-361-5p PPP3CB 0.21454431962475 0.0800957579368424 -0.217161149975175 0.026537796620393 miRanda -0.127974103120468 0.000592380004256261 NA NA NA hsa-miR-361-5p PPP3CC 0.21454431962475 0.0800957579368424 -0.864879436917075 5.11810186256782e-12 miRanda -0.162282770575647 0.000912467378574366 NA NA NA hsa-miR-181a-5p PPP3R1 -0.375429731222937 0.0562142867129802 -0.021451907795778 0.828812244123992 MirTarget;miRNATAP -0.174665544764319 9.40491398689482e-15 NA NA NA hsa-miR-181b-5p PPP3R1 0.668793269169928 0.000239998092406404 -0.021451907795778 0.828812244123992 MirTarget;miRNATAP -0.114349020464675 3.84750784901666e-06 NA NA NA hsa-miR-181c-5p PPP3R1 0.529875814537156 0.0125885822998008 -0.021451907795778 0.828812244123992 MirTarget;miRNATAP -0.106737924157465 4.8061231789594e-07 NA NA NA hsa-miR-27b-3p PPP3R1 0.236438984240408 0.12263510345883 -0.021451907795778 0.828812244123992 miRNATAP -0.122284709618602 4.10399666262129e-05 NA NA NA hsa-miR-30b-5p PPP3R1 0.358144314839612 0.138026229059594 -0.021451907795778 0.828812244123992 MirTarget -0.109418887183495 3.74739901258502e-09 NA NA NA hsa-miR-30c-5p PPP3R1 -0.327319105755825 0.123595832152687 -0.021451907795778 0.828812244123992 MirTarget;miRNATAP -0.157231202749467 5.03548982239333e-14 NA NA NA hsa-miR-342-3p PPP3R1 -0.128691966564961 0.561034080130801 -0.021451907795778 0.828812244123992 MirTarget;miRanda;miRNATAP -0.120856614371424 2.53668736670026e-09 NA NA NA hsa-miR-34a-5p PPP3R1 1.40588612517769 8.60097477768592e-12 -0.021451907795778 0.828812244123992 miRNAWalker2_validate -0.170360603226023 4.36468130338985e-16 NA NA NA hsa-miR-141-3p PRKACB 3.36993755486106 5.42939251147195e-32 -0.337490057919314 0.0956151593593903 MirTarget;TargetScan;miRNATAP -0.127873218774198 2.27329955972899e-05 NA NA NA hsa-miR-146b-5p PRKACB 1.0922867893808 5.63754607494775e-06 -0.337490057919314 0.0956151593593903 miRanda -0.16173584971976 2.34820463010476e-05 NA NA NA hsa-miR-16-2-3p PRKACB 0.503964803530872 0.0263648405197492 -0.337490057919314 0.0956151593593903 mirMAP -0.126437256197819 0.00465216057285952 NA NA NA hsa-miR-17-5p PRKACB 2.07078488653279 2.77403038572568e-19 -0.337490057919314 0.0956151593593903 TargetScan -0.146235921583623 0.000160820334409303 NA NA NA hsa-miR-182-5p PRKACB 3.21839823004635 5.13049145201115e-39 -0.337490057919314 0.0956151593593903 MirTarget;miRNATAP -0.112248448456467 0.00121734908239389 NA NA NA hsa-miR-183-5p PRKACB 2.39247234736657 3.92444525331999e-21 -0.337490057919314 0.0956151593593903 MirTarget -0.10185724563834 0.0037757174706069 NA NA NA hsa-miR-19a-3p PRKACB 2.11776595911517 7.07663078397156e-10 -0.337490057919314 0.0956151593593903 MirTarget;miRNATAP -0.170735517959884 5.74076627300856e-08 NA NA NA hsa-miR-19b-3p PRKACB 2.10868505662119 5.40846613768389e-17 -0.337490057919314 0.0956151593593903 miRNAWalker2_validate;MirTarget;miRNATAP -0.197277470144974 1.27039043015725e-07 NA NA NA hsa-miR-200b-3p PRKACB 1.55157578247391 4.83790020897188e-09 -0.337490057919314 0.0956151593593903 MirTarget;TargetScan -0.101454883897731 0.00336247964553013 NA NA NA hsa-miR-200c-3p PRKACB 0.380533388300368 0.0842181838538353 -0.337490057919314 0.0956151593593903 MirTarget;miRNATAP -0.115374415768757 0.00655504187350906 NA NA NA hsa-miR-339-5p PRKACB 0.536997313601114 0.0488090394176611 -0.337490057919314 0.0956151593593903 miRanda -0.172209477372762 3.7061891291678e-07 NA NA NA hsa-miR-34a-5p PRKACB 1.40588612517769 8.60097477768592e-12 -0.337490057919314 0.0956151593593903 miRNATAP -0.249544715069385 1.25392359331725e-08 NA NA NA hsa-miR-362-5p PRKACB 0.658947634569393 0.0243306847205756 -0.337490057919314 0.0956151593593903 PITA -0.152310553896922 2.5944554975563e-06 NA NA NA hsa-miR-429 PRKACB 2.3794516574089 1.72813419703734e-13 -0.337490057919314 0.0956151593593903 MirTarget;PITA;miRanda;miRNATAP -0.120289214888389 7.31299726157361e-05 NA NA NA hsa-miR-590-5p PRKACB 2.07441240363458 4.95240551694843e-14 -0.337490057919314 0.0956151593593903 miRanda -0.106057390676399 0.00956598336443456 NA NA NA hsa-miR-93-5p PRKACB 1.50844106515467 1.83836866996875e-12 -0.337490057919314 0.0956151593593903 miRNAWalker2_validate -0.173603248772151 4.27230598908178e-05 NA NA NA hsa-miR-96-5p PRKACB 3.0381097138467 4.40362891630201e-24 -0.337490057919314 0.0956151593593903 miRNATAP -0.19117539499709 1.28710220181067e-08 NA NA NA hsa-miR-17-3p PRKCA 1.36706429551147 4.60388403547821e-13 -0.189679589892687 0.471078192212991 miRNAWalker2_validate -0.2211557176846 0.000413342702730225 NA NA NA hsa-miR-181c-5p PRKCA 0.529875814537156 0.0125885822998008 -0.189679589892687 0.471078192212991 mirMAP -0.326745565499583 6.66432412436314e-09 NA NA NA hsa-miR-183-5p PRKCA 2.39247234736657 3.92444525331999e-21 -0.189679589892687 0.471078192212991 miRNATAP -0.191021307259656 2.63755654536705e-05 NA NA NA hsa-miR-193b-3p PRKCA 1.10444771306846 0.000822888533401377 -0.189679589892687 0.471078192212991 miRNAWalker2_validate -0.138487066621768 0.000138664149309437 NA NA NA hsa-miR-193b-5p PRKCA 0.179695858885499 0.55521472494233 -0.189679589892687 0.471078192212991 mirMAP -0.137899397693864 0.000521039895191079 NA NA NA hsa-miR-19b-1-5p PRKCA 1.71217036351784 3.28561659177495e-12 -0.189679589892687 0.471078192212991 mirMAP -0.210975845049586 0.000143708055393517 NA NA NA hsa-miR-200c-3p PRKCA 0.380533388300368 0.0842181838538353 -0.189679589892687 0.471078192212991 miRNATAP -0.262911308228053 1.5097135867061e-06 NA NA NA hsa-miR-22-5p PRKCA 1.71436244278242 9.85038001236064e-15 -0.189679589892687 0.471078192212991 mirMAP -0.177526746625668 0.000829577475678236 NA NA NA hsa-miR-429 PRKCA 2.3794516574089 1.72813419703734e-13 -0.189679589892687 0.471078192212991 miRanda;miRNATAP -0.142853746691809 0.000293353456114152 NA NA NA hsa-miR-590-3p PRKCA 0.83851360565783 0.00129224433453587 -0.189679589892687 0.471078192212991 PITA;miRanda;mirMAP;miRNATAP -0.19448195031258 0.000455368438666445 NA NA NA hsa-miR-92a-3p PRKCA -0.136362762339122 0.493412263619364 -0.189679589892687 0.471078192212991 miRNAWalker2_validate -0.160805726714066 0.00861285946041943 NA NA NA hsa-miR-93-3p PRKCA 1.07631808403007 1.63747525692813e-05 -0.189679589892687 0.471078192212991 mirMAP -0.159060267220526 0.000935006714973491 NA NA NA hsa-miR-141-5p PRKCB 3.02575703771074 1.54385222591327e-32 -1.01521651364956 0.000234705382361064 mirMAP -0.19965194499171 1.76112086865619e-05 NA NA NA hsa-miR-200b-3p PRKCB 1.55157578247391 4.83790020897188e-09 -1.01521651364956 0.000234705382361064 MirTarget -0.139521777238666 0.00328113460432514 NA NA NA hsa-miR-200c-3p PRKCB 0.380533388300368 0.0842181838538353 -1.01521651364956 0.000234705382361064 MirTarget;miRNATAP -0.217004467533231 0.000183295321414174 NA NA NA hsa-miR-335-3p PRKCB 1.51116383169018 6.88553098788624e-13 -1.01521651364956 0.000234705382361064 mirMAP -0.246405652657792 3.09182980578855e-05 NA NA NA hsa-miR-429 PRKCB 2.3794516574089 1.72813419703734e-13 -1.01521651364956 0.000234705382361064 MirTarget;miRanda;miRNATAP -0.166472060253132 6.28432741975052e-05 NA NA NA hsa-miR-450b-5p PRKCB 1.69248953402469 1.96052058003353e-07 -1.01521651364956 0.000234705382361064 miRNATAP -0.183354145967975 2.13964194654069e-05 NA NA NA hsa-miR-589-3p PRKCB 1.34253876396688 1.84935927493927e-05 -1.01521651364956 0.000234705382361064 mirMAP -0.153872579100374 0.000218865142512993 NA NA NA hsa-miR-589-5p PRKCB 0.233778899379261 0.228477190986199 -1.01521651364956 0.000234705382361064 mirMAP -0.191889757915074 0.00377217964937973 NA NA NA hsa-miR-590-5p PRKCB 2.07441240363458 4.95240551694843e-14 -1.01521651364956 0.000234705382361064 miRanda -0.247831270781318 8.78932489501914e-06 NA NA NA hsa-miR-2110 PRKCG -1.92124860612475 1.1464887721828e-12 1.66883505426905 0.000268885102920086 MirTarget -0.307845409938279 6.49952836801256e-05 NA NA NA hsa-miR-326 PRKCG -0.992397386750901 0.00335173765975096 1.66883505426905 0.000268885102920086 miRanda -0.268960075781158 1.49724165244188e-05 NA NA NA hsa-miR-335-5p PRKCG -0.466533891325811 0.0676987038122831 1.66883505426905 0.000268885102920086 miRNAWalker2_validate -0.28334410784476 0.00233636911178136 NA NA NA hsa-miR-450b-5p PRKX 1.69248953402469 1.96052058003353e-07 -0.138434262119447 0.395012462656297 mirMAP -0.119346741491602 2.11739235739311e-06 NA NA NA hsa-miR-542-3p PRKX 1.62226640768239 2.6427102465476e-10 -0.138434262119447 0.395012462656297 mirMAP -0.149271020180693 1.30948834311169e-07 NA NA NA hsa-let-7g-3p PTPN5 2.38336858943031 4.8771148585792e-17 -4.33701566712629 2.47484874334855e-24 MirTarget -0.301188787387364 1.66043612936982e-05 NA NA NA hsa-miR-128-3p PTPN5 1.03509868349735 2.11606310588315e-10 -4.33701566712629 2.47484874334855e-24 MirTarget -0.466736900372743 0.000194632425398957 NA NA NA hsa-miR-429 PTPN5 2.3794516574089 1.72813419703734e-13 -4.33701566712629 2.47484874334855e-24 miRanda -0.29849703614265 8.9677415749973e-06 NA NA NA hsa-miR-744-3p PTPN5 2.07439104592565 3.30645434602132e-12 -4.33701566712629 2.47484874334855e-24 MirTarget -0.241692556961618 0.000353642698574113 NA NA NA hsa-miR-125a-3p PTPN7 -1.04954492275266 2.45974219476832e-06 0.684311515493473 0.00655308339290277 miRanda -0.151236852421308 0.00348233763814563 NA NA NA hsa-miR-335-5p PTPN7 -0.466533891325811 0.0676987038122831 0.684311515493473 0.00655308339290277 miRNAWalker2_validate -0.165579526622504 0.00114800778647346 NA NA NA hsa-miR-15a-5p PTPRR 1.62575353599172 1.55312121019827e-19 -1.63637251423085 0.00012073818017565 MirTarget -0.417092096020268 7.76916306046686e-05 NA NA NA hsa-miR-16-1-3p PTPRR 1.50034693398929 6.63958242991125e-10 -1.63637251423085 0.00012073818017565 MirTarget -0.331558884002702 0.000828676123013775 NA NA NA hsa-miR-20a-3p PTPRR 2.51803599558247 4.92479325298629e-13 -1.63637251423085 0.00012073818017565 MirTarget;miRNATAP -0.192742208768951 0.00692378194663442 NA NA NA hsa-miR-424-5p PTPRR 1.26485330287919 6.1498991028257e-06 -1.63637251423085 0.00012073818017565 MirTarget -0.183529194589755 0.00871611101393373 NA NA NA hsa-miR-450b-5p PTPRR 1.69248953402469 1.96052058003353e-07 -1.63637251423085 0.00012073818017565 MirTarget;PITA;miRNATAP -0.263844542212713 7.62807371911369e-05 NA NA NA hsa-miR-589-3p PTPRR 1.34253876396688 1.84935927493927e-05 -1.63637251423085 0.00012073818017565 MirTarget -0.185893031385112 0.00392765254728381 NA NA NA hsa-miR-30c-5p RAC1 -0.327319105755825 0.123595832152687 0.217355195910818 0.0528286499053578 miRNAWalker2_validate -0.11419324793125 2.23761362474291e-06 NA NA NA hsa-miR-193b-3p RAC2 1.10444771306846 0.000822888533401377 -0.656275624483639 0.00297441142612925 miRNAWalker2_validate -0.112838589622127 0.000231783502607722 NA NA NA hsa-miR-125a-5p RAC3 -1.04824536696301 3.97386082850476e-07 1.82835649257478 3.33704760151114e-09 PITA -0.183541043002533 0.00831332585841968 NA NA NA hsa-miR-30c-2-3p RAC3 -3.10905250533941 6.84550165664783e-27 1.82835649257478 3.33704760151114e-09 miRNAWalker2_validate -0.370936437115312 5.24524075378395e-16 NA NA NA hsa-miR-16-2-3p RAP1A 0.503964803530872 0.0263648405197492 -0.603987305278772 9.11805459598191e-08 MirTarget;mirMAP -0.106891491539267 1.98650883323999e-05 NA NA NA hsa-miR-19a-3p RAP1A 2.11776595911517 7.07663078397156e-10 -0.603987305278772 9.11805459598191e-08 MirTarget;miRNATAP -0.157123037526092 8.30080921474088e-20 NA NA NA hsa-miR-19b-3p RAP1A 2.10868505662119 5.40846613768389e-17 -0.603987305278772 9.11805459598191e-08 MirTarget;miRNATAP -0.175406562788395 1.47000077647285e-17 NA NA NA hsa-miR-25-3p RAP1A 0.361927330834176 0.0163670566170988 -0.603987305278772 9.11805459598191e-08 mirMAP -0.115157280326491 0.00105562262009864 NA NA NA hsa-miR-324-5p RAP1A 1.06955541886548 5.39722006604758e-05 -0.603987305278772 9.11805459598191e-08 miRanda -0.154377217785499 7.03803242145569e-16 NA NA NA hsa-miR-335-3p RAP1A 1.51116383169018 6.88553098788624e-13 -0.603987305278772 9.11805459598191e-08 mirMAP -0.110111758660811 5.70175474136553e-06 NA NA NA hsa-miR-664a-3p RAP1A 0.443077463053857 0.0214248925850984 -0.603987305278772 9.11805459598191e-08 mirMAP -0.110687522710715 4.94872229467202e-05 NA NA NA hsa-miR-7-1-3p RAP1A 2.61364240402652 1.98959237815786e-32 -0.603987305278772 9.11805459598191e-08 mirMAP -0.128455351235968 3.0268199804302e-08 NA NA NA hsa-miR-92a-3p RAP1A -0.136362762339122 0.493412263619364 -0.603987305278772 9.11805459598191e-08 mirMAP;miRNATAP -0.14296374476131 5.16925020581449e-08 NA NA NA hsa-miR-181c-5p RAP1B 0.529875814537156 0.0125885822998008 -0.417268909306394 0.00207583774926411 MirTarget;miRNATAP -0.108062036854663 0.00023571671707159 NA NA NA hsa-miR-19a-3p RAP1B 2.11776595911517 7.07663078397156e-10 -0.417268909306394 0.00207583774926411 MirTarget;miRNATAP -0.13453800931744 1.36134874659401e-10 NA NA NA hsa-miR-19b-3p RAP1B 2.10868505662119 5.40846613768389e-17 -0.417268909306394 0.00207583774926411 MirTarget;miRNATAP -0.178926166950946 4.39964114081487e-13 NA NA NA hsa-miR-200b-3p RAP1B 1.55157578247391 4.83790020897188e-09 -0.417268909306394 0.00207583774926411 MirTarget;TargetScan -0.100968257550172 1.19178136736062e-05 NA NA NA hsa-miR-25-3p RAP1B 0.361927330834176 0.0163670566170988 -0.417268909306394 0.00207583774926411 MirTarget;miRNATAP -0.114384070887763 0.00628917356203576 NA NA NA hsa-miR-27b-3p RAP1B 0.236438984240408 0.12263510345883 -0.417268909306394 0.00207583774926411 MirTarget -0.124182010202537 0.00259619765230713 NA NA NA hsa-miR-30b-5p RAP1B 0.358144314839612 0.138026229059594 -0.417268909306394 0.00207583774926411 MirTarget -0.158691377313009 4.94355444608665e-10 NA NA NA hsa-miR-30c-5p RAP1B -0.327319105755825 0.123595832152687 -0.417268909306394 0.00207583774926411 MirTarget;miRNATAP -0.167435099209743 8.86891242793365e-09 NA NA NA hsa-miR-30d-5p RAP1B -0.920901858717441 3.50898334321668e-05 -0.417268909306394 0.00207583774926411 MirTarget;miRNATAP -0.123352169318874 8.8745038347385e-06 NA NA NA hsa-miR-92a-3p RAP1B -0.136362762339122 0.493412263619364 -0.417268909306394 0.00207583774926411 MirTarget;miRNATAP -0.117343559671965 0.00019224829545818 NA NA NA hsa-miR-92b-3p RAP1B 0.0478787637665503 0.831716894621477 -0.417268909306394 0.00207583774926411 MirTarget;miRNATAP -0.108575387170973 9.06328904550033e-05 NA NA NA hsa-miR-106a-5p RAPGEF2 1.3902608059488 6.07931522284525e-05 -0.844531219425732 2.45585277201692e-10 MirTarget;miRNATAP -0.112721055366931 1.13411607906843e-08 NA NA NA hsa-miR-106b-5p RAPGEF2 1.47447672652218 1.32004094930462e-13 -0.844531219425732 2.45585277201692e-10 MirTarget;miRNATAP -0.188362528356074 4.32746947456816e-10 NA NA NA hsa-miR-10a-5p RAPGEF2 0.790595816051606 0.000593731378445468 -0.844531219425732 2.45585277201692e-10 miRNATAP -0.101581183174716 0.00016882124067455 NA NA NA hsa-miR-155-5p RAPGEF2 0.813513839059142 0.000608282725633232 -0.844531219425732 2.45585277201692e-10 miRNAWalker2_validate;MirTarget -0.120147260735176 4.10750188249374e-06 NA NA NA hsa-miR-15a-5p RAPGEF2 1.62575353599172 1.55312121019827e-19 -0.844531219425732 2.45585277201692e-10 miRNATAP -0.143064365053891 1.81588421933731e-05 NA NA NA hsa-miR-16-5p RAPGEF2 0.749619098384047 4.11649450706988e-06 -0.844531219425732 2.45585277201692e-10 miRNATAP -0.141111314367745 0.000226244342112299 NA NA NA hsa-miR-17-5p RAPGEF2 2.07078488653279 2.77403038572568e-19 -0.844531219425732 2.45585277201692e-10 MirTarget;TargetScan;miRNATAP -0.14263247841713 3.08490031476087e-08 NA NA NA hsa-miR-193a-3p RAPGEF2 0.549173467360291 0.0319030569365466 -0.844531219425732 2.45585277201692e-10 miRanda -0.140136180143399 9.19881354644379e-08 NA NA NA hsa-miR-20a-5p RAPGEF2 2.64649625616975 5.1469418982085e-27 -0.844531219425732 2.45585277201692e-10 MirTarget;miRNATAP -0.110905546785501 3.24757531016428e-06 NA NA NA hsa-miR-339-5p RAPGEF2 0.536997313601114 0.0488090394176611 -0.844531219425732 2.45585277201692e-10 MirTarget;PITA -0.101914421880765 7.74889325799792e-06 NA NA NA hsa-miR-374b-3p RAPGEF2 -0.157526212601818 0.538677664999491 -0.844531219425732 2.45585277201692e-10 MirTarget -0.101498248157135 0.000617401989289756 NA NA NA hsa-miR-421 RAPGEF2 0.170525317701774 0.535277026680289 -0.844531219425732 2.45585277201692e-10 miRanda;miRNATAP -0.113181466854684 4.0901693569177e-06 NA NA NA hsa-miR-542-3p RAPGEF2 1.62226640768239 2.6427102465476e-10 -0.844531219425732 2.45585277201692e-10 miRanda -0.122612164231427 2.19685935141459e-07 NA NA NA hsa-miR-590-3p RAPGEF2 0.83851360565783 0.00129224433453587 -0.844531219425732 2.45585277201692e-10 miRanda -0.16035116153108 1.53963440566124e-08 NA NA NA hsa-miR-93-5p RAPGEF2 1.50844106515467 1.83836866996875e-12 -0.844531219425732 2.45585277201692e-10 MirTarget;miRNATAP -0.194885367069931 3.25168763258658e-12 NA NA NA hsa-miR-130b-3p RASA1 1.83046548750752 5.04753914574694e-13 0.0830814913632443 0.570442868486062 MirTarget -0.125028016496831 3.93404024277248e-06 NA NA NA hsa-miR-320b RASA1 0.226640952564488 0.378818692487242 0.0830814913632443 0.570442868486062 MirTarget;PITA;miRanda;miRNATAP -0.115959001937082 8.13385461561195e-06 NA NA NA hsa-miR-330-5p RASA1 0.168520831101569 0.336433937906706 0.0830814913632443 0.570442868486062 miRanda -0.111577183760699 0.00389299758466792 NA NA NA hsa-miR-421 RASA1 0.170525317701774 0.535277026680289 0.0830814913632443 0.570442868486062 MirTarget;PITA;miRanda;miRNATAP -0.127023094202489 1.48010705227606e-06 NA NA NA hsa-miR-454-3p RASA1 1.49453641052169 4.46235742871434e-09 0.0830814913632443 0.570442868486062 MirTarget -0.124196414032519 6.07092903847995e-05 NA NA NA hsa-miR-590-3p RASA1 0.83851360565783 0.00129224433453587 0.0830814913632443 0.570442868486062 miRanda -0.159770357317914 1.69631651700077e-07 NA NA NA hsa-miR-590-5p RASA1 2.07441240363458 4.95240551694843e-14 0.0830814913632443 0.570442868486062 miRNATAP -0.148865940378909 3.4625557396617e-07 NA NA NA hsa-miR-141-3p RASA2 3.36993755486106 5.42939251147195e-32 -0.122908970487031 0.513876717364579 TargetScan -0.124746567469002 8.33312500699408e-06 NA NA NA hsa-miR-30b-5p RASA2 0.358144314839612 0.138026229059594 -0.122908970487031 0.513876717364579 mirMAP -0.162230314445943 5.4166425604864e-06 NA NA NA hsa-miR-335-5p RASA2 -0.466533891325811 0.0676987038122831 -0.122908970487031 0.513876717364579 miRNAWalker2_validate -0.123917328048337 0.00108261070271957 NA NA NA hsa-miR-664a-3p RASA2 0.443077463053857 0.0214248925850984 -0.122908970487031 0.513876717364579 mirMAP -0.178593261369568 7.01250096406581e-05 NA NA NA hsa-miR-127-5p RASGRF1 2.05164948368907 3.61318574536718e-09 -3.70733405775563 1.10306468296224e-12 MirTarget -0.203114377416237 0.00348610022536499 NA NA NA hsa-miR-320b RASGRF1 0.226640952564488 0.378818692487242 -3.70733405775563 1.10306468296224e-12 miRanda -0.256365411096161 0.00749810890372983 NA NA NA hsa-miR-331-5p RASGRF1 0.578237334664505 0.00131211239210882 -3.70733405775563 1.10306468296224e-12 miRNATAP -0.392217378465777 0.00536866354811249 NA NA NA hsa-miR-454-3p RASGRF1 1.49453641052169 4.46235742871434e-09 -3.70733405775563 1.10306468296224e-12 mirMAP -0.371087102816134 0.00111169312696212 NA NA NA hsa-miR-675-3p RASGRF1 0.319853014141687 0.608023216370348 -3.70733405775563 1.10306468296224e-12 MirTarget -0.155760735845356 0.000129683343299328 NA NA NA hsa-miR-708-3p RASGRF1 3.43841959417743 4.40027692981683e-28 -3.70733405775563 1.10306468296224e-12 mirMAP -0.495369446215287 1.18199246105259e-09 NA NA NA hsa-miR-106a-5p RASGRF2 1.3902608059488 6.07931522284525e-05 -0.287352893796794 0.257335594453799 MirTarget -0.144051926956735 0.000108587452832706 NA NA NA hsa-miR-106b-5p RASGRF2 1.47447672652218 1.32004094930462e-13 -0.287352893796794 0.257335594453799 MirTarget -0.285206361233893 5.05993782578971e-07 NA NA NA hsa-miR-1266-5p RASGRF2 -0.289721391624349 0.281500764553995 -0.287352893796794 0.257335594453799 MirTarget -0.19033934438021 1.05285663067015e-05 NA NA NA hsa-miR-17-5p RASGRF2 2.07078488653279 2.77403038572568e-19 -0.287352893796794 0.257335594453799 MirTarget;TargetScan -0.261351718418575 5.66980196022638e-08 NA NA NA hsa-miR-182-5p RASGRF2 3.21839823004635 5.13049145201115e-39 -0.287352893796794 0.257335594453799 mirMAP -0.158375356189279 0.000262464376525276 NA NA NA hsa-miR-20a-5p RASGRF2 2.64649625616975 5.1469418982085e-27 -0.287352893796794 0.257335594453799 MirTarget -0.217638242084763 9.73169257314874e-07 NA NA NA hsa-miR-3065-5p RASGRF2 0.653308707552535 0.0999497219778851 -0.287352893796794 0.257335594453799 mirMAP -0.117859340340122 0.000214759070927914 NA NA NA hsa-miR-30d-3p RASGRF2 0.00396376345349925 0.986457040013182 -0.287352893796794 0.257335594453799 mirMAP -0.227429688703671 4.89152043056184e-05 NA NA NA hsa-miR-324-5p RASGRF2 1.06955541886548 5.39722006604758e-05 -0.287352893796794 0.257335594453799 miRNATAP -0.177991731039237 4.44152156318357e-05 NA NA NA hsa-miR-3614-5p RASGRF2 -1.19394699210224 2.53933783780868e-05 -0.287352893796794 0.257335594453799 MirTarget -0.111065218214539 0.00670194283927968 NA NA NA hsa-miR-421 RASGRF2 0.170525317701774 0.535277026680289 -0.287352893796794 0.257335594453799 miRanda;mirMAP -0.160002931287835 0.000519961515110835 NA NA NA hsa-miR-429 RASGRF2 2.3794516574089 1.72813419703734e-13 -0.287352893796794 0.257335594453799 miRanda -0.179178495421922 2.20550434430322e-06 NA NA NA hsa-miR-590-5p RASGRF2 2.07441240363458 4.95240551694843e-14 -0.287352893796794 0.257335594453799 miRanda -0.161156050929219 0.00163754848848733 NA NA NA hsa-miR-93-5p RASGRF2 1.50844106515467 1.83836866996875e-12 -0.287352893796794 0.257335594453799 MirTarget -0.301711451461713 1.02031758886157e-08 NA NA NA hsa-miR-148b-3p RASGRP1 0.483970528590224 0.0026495409465901 0.22596138326471 0.410804336760924 MirTarget -0.312744556962803 7.01733576317429e-05 NA NA NA hsa-miR-17-3p RASGRP1 1.36706429551147 4.60388403547821e-13 0.22596138326471 0.410804336760924 MirTarget -0.171494116861819 0.00892405874048536 NA NA NA hsa-miR-2355-3p RASGRP1 1.10676344164715 6.24068383465151e-06 0.22596138326471 0.410804336760924 MirTarget -0.226445417036981 2.55407091052512e-05 NA NA NA hsa-miR-320b RASGRP1 0.226640952564488 0.378818692487242 0.22596138326471 0.410804336760924 miRanda -0.18084750476964 0.000226735231862998 NA NA NA hsa-miR-331-5p RASGRP1 0.578237334664505 0.00131211239210882 0.22596138326471 0.410804336760924 PITA;miRNATAP -0.226695457613606 0.00169965895293423 NA NA NA hsa-miR-335-5p RASGRP1 -0.466533891325811 0.0676987038122831 0.22596138326471 0.410804336760924 miRNAWalker2_validate -0.20840084575315 0.000163607256537204 NA NA NA hsa-miR-582-5p RASGRP1 1.08286181406653 0.00149040450161757 0.22596138326471 0.410804336760924 MirTarget -0.105781090882875 0.00520880833224736 NA NA NA hsa-miR-590-5p RASGRP1 2.07441240363458 4.95240551694843e-14 0.22596138326471 0.410804336760924 MirTarget;PITA;miRanda;miRNATAP -0.228220127040697 3.55733291464349e-05 NA NA NA hsa-miR-28-5p RASGRP2 1.19639196514745 4.59365801666536e-18 -1.70792894200752 7.20369044586562e-08 miRNATAP -0.348829561390059 0.000844065552095291 NA NA NA hsa-miR-940 RASGRP2 0.011138136211269 0.974925352379525 -1.70792894200752 7.20369044586562e-08 MirTarget;PITA;miRNATAP -0.124206075895981 0.00824270080689898 NA NA NA hsa-miR-324-3p RASGRP3 -0.0774700133118458 0.689226297032231 -0.262127468715428 0.124284914851264 MirTarget -0.147946379885594 0.000272445945719952 NA NA NA hsa-miR-590-5p RASGRP3 2.07441240363458 4.95240551694843e-14 -0.262127468715428 0.124284914851264 miRanda -0.109122755261431 0.00150156761622915 NA NA NA hsa-miR-28-5p RASGRP4 1.19639196514745 4.59365801666536e-18 -2.53021554805935 2.73320608789663e-19 miRanda -0.410286265509764 1.57380700977574e-05 NA NA NA hsa-miR-542-3p RASGRP4 1.62226640768239 2.6427102465476e-10 -2.53021554805935 2.73320608789663e-19 miRanda -0.173477338007722 0.000776399032176071 NA NA NA hsa-miR-625-5p RASGRP4 1.38208523187596 6.28473801440755e-07 -2.53021554805935 2.73320608789663e-19 MirTarget -0.146975162377984 0.00645598627434084 NA NA NA hsa-miR-106b-5p RPS6KA1 1.47447672652218 1.32004094930462e-13 -0.579524551675261 6.59532330551602e-06 miRNATAP -0.170585553839829 3.30400709254468e-09 NA NA NA hsa-miR-17-5p RPS6KA1 2.07078488653279 2.77403038572568e-19 -0.579524551675261 6.59532330551602e-06 TargetScan;miRNATAP -0.127198057927073 2.37610720642865e-07 NA NA NA hsa-miR-335-3p RPS6KA1 1.51116383169018 6.88553098788624e-13 -0.579524551675261 6.59532330551602e-06 MirTarget -0.162897661929928 2.431088402922e-09 NA NA NA hsa-miR-421 RPS6KA1 0.170525317701774 0.535277026680289 -0.579524551675261 6.59532330551602e-06 PITA;miRanda -0.128026047772527 3.99920194868673e-08 NA NA NA hsa-miR-93-5p RPS6KA1 1.50844106515467 1.83836866996875e-12 -0.579524551675261 6.59532330551602e-06 miRNATAP -0.116839091711322 1.6238645273994e-05 NA NA NA hsa-let-7g-3p RPS6KA2 2.38336858943031 4.8771148585792e-17 -1.04343331479045 1.62125928478786e-06 MirTarget -0.104782266150183 0.00230430762602138 NA NA NA hsa-miR-130b-5p RPS6KA2 1.53645187062942 1.10498816261505e-08 -1.04343331479045 1.62125928478786e-06 mirMAP -0.218195907469878 2.36792623924417e-09 NA NA NA hsa-miR-17-5p RPS6KA2 2.07078488653279 2.77403038572568e-19 -1.04343331479045 1.62125928478786e-06 TargetScan -0.237976044364187 1.13643203010135e-08 NA NA NA hsa-miR-193a-3p RPS6KA2 0.549173467360291 0.0319030569365466 -1.04343331479045 1.62125928478786e-06 mirMAP -0.236767612468823 2.40694553868879e-08 NA NA NA hsa-miR-193b-3p RPS6KA2 1.10444771306846 0.000822888533401377 -1.04343331479045 1.62125928478786e-06 mirMAP -0.126899545109533 2.89329618031281e-05 NA NA NA hsa-miR-19a-3p RPS6KA2 2.11776595911517 7.07663078397156e-10 -1.04343331479045 1.62125928478786e-06 MirTarget -0.116355097297911 0.00074614825058899 NA NA NA hsa-miR-21-3p RPS6KA2 2.54206008030157 1.11598785398763e-30 -1.04343331479045 1.62125928478786e-06 MirTarget -0.148330264666295 0.000543858038536522 NA NA NA hsa-miR-9-5p RPS6KA2 4.99250901331516 2.59132733422801e-19 -1.04343331479045 1.62125928478786e-06 miRNATAP -0.130728183864576 1.3447378269276e-14 NA NA NA hsa-miR-93-3p RPS6KA2 1.07631808403007 1.63747525692813e-05 -1.04343331479045 1.62125928478786e-06 MirTarget -0.2105417211806 1.25415597157338e-07 NA NA NA hsa-miR-106a-5p RPS6KA3 1.3902608059488 6.07931522284525e-05 -0.054195404659354 0.708624881834648 miRNATAP -0.101192877969631 1.67110384493832e-06 NA NA NA hsa-miR-106b-5p RPS6KA3 1.47447672652218 1.32004094930462e-13 -0.054195404659354 0.708624881834648 miRNATAP -0.143779184370637 9.44910304249055e-06 NA NA NA hsa-miR-140-5p RPS6KA3 0.669142684153918 0.000335928403032308 -0.054195404659354 0.708624881834648 PITA;miRanda;miRNATAP -0.101226805597237 0.00573251834087782 NA NA NA hsa-miR-15a-5p RPS6KA3 1.62575353599172 1.55312121019827e-19 -0.054195404659354 0.708624881834648 MirTarget;miRNATAP -0.118757114096311 0.000871264793923372 NA NA NA hsa-miR-16-2-3p RPS6KA3 0.503964803530872 0.0263648405197492 -0.054195404659354 0.708624881834648 mirMAP -0.172483371225758 4.47653889948318e-08 NA NA NA hsa-miR-16-5p RPS6KA3 0.749619098384047 4.11649450706988e-06 -0.054195404659354 0.708624881834648 miRNAWalker2_validate;MirTarget;miRNATAP -0.165220770211374 4.86739262441925e-05 NA NA NA hsa-miR-17-5p RPS6KA3 2.07078488653279 2.77403038572568e-19 -0.054195404659354 0.708624881834648 TargetScan;miRNATAP -0.173679048296375 1.94712725304908e-10 NA NA NA hsa-miR-186-5p RPS6KA3 0.852175445703945 6.88885738584309e-10 -0.054195404659354 0.708624881834648 MirTarget;mirMAP;miRNATAP -0.176300481853613 0.000226582290752102 NA NA NA hsa-miR-20a-5p RPS6KA3 2.64649625616975 5.1469418982085e-27 -0.054195404659354 0.708624881834648 miRNATAP -0.138269696703583 4.38347399641463e-08 NA NA NA hsa-miR-320b RPS6KA3 0.226640952564488 0.378818692487242 -0.054195404659354 0.708624881834648 miRanda -0.108216454551594 2.67401563925856e-05 NA NA NA hsa-miR-590-3p RPS6KA3 0.83851360565783 0.00129224433453587 -0.054195404659354 0.708624881834648 mirMAP -0.113580912429783 0.000193243638199445 NA NA NA hsa-miR-590-5p RPS6KA3 2.07441240363458 4.95240551694843e-14 -0.054195404659354 0.708624881834648 PITA;mirMAP;miRNATAP -0.185485877537653 1.00317938157498e-10 NA NA NA hsa-miR-7-1-3p RPS6KA3 2.61364240402652 1.98959237815786e-32 -0.054195404659354 0.708624881834648 mirMAP -0.102247713678445 0.000565084636142267 NA NA NA hsa-miR-93-5p RPS6KA3 1.50844106515467 1.83836866996875e-12 -0.054195404659354 0.708624881834648 miRNATAP -0.156371244608171 2.09555576720906e-07 NA NA NA hsa-miR-199a-5p RPS6KA5 1.3057193856884 2.38429382751645e-08 -0.922365443597163 2.46555056372225e-05 miRanda -0.150106318542769 0.000443196030399003 NA NA NA hsa-miR-199b-5p RPS6KA5 2.13822205171062 4.56262988762436e-15 -0.922365443597163 2.46555056372225e-05 miRanda -0.1172587339088 0.0011394207427992 NA NA NA hsa-miR-19a-3p RPS6KA5 2.11776595911517 7.07663078397156e-10 -0.922365443597163 2.46555056372225e-05 miRNAWalker2_validate;MirTarget -0.10595787420931 0.00221027030945205 NA NA NA hsa-miR-19b-3p RPS6KA5 2.10868505662119 5.40846613768389e-17 -0.922365443597163 2.46555056372225e-05 MirTarget -0.114756075152692 0.00522836483046972 NA NA NA hsa-miR-20a-5p RPS6KA5 2.64649625616975 5.1469418982085e-27 -0.922365443597163 2.46555056372225e-05 MirTarget -0.113122601503186 0.00368624706419212 NA NA NA hsa-miR-23a-3p RPS6KA5 0.111958289789488 0.393086414480463 -0.922365443597163 2.46555056372225e-05 mirMAP -0.213073740425602 0.00687930111859921 NA NA NA hsa-miR-27a-3p RPS6KA5 0.433402568013802 0.00737164631768323 -0.922365443597163 2.46555056372225e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.321133810846985 2.86783338239528e-07 NA NA NA hsa-miR-199a-3p RPS6KA6 1.67715607711377 5.96963028176444e-15 -0.310498541708228 0.547641965662978 MirTarget -0.277912316945002 0.00987095228027099 NA NA NA hsa-miR-199b-3p RPS6KA6 1.67802185853505 6.03525898173555e-15 -0.310498541708228 0.547641965662978 MirTarget -0.277893304567427 0.00982473730357434 NA NA NA hsa-miR-424-5p RPS6KA6 1.26485330287919 6.1498991028257e-06 -0.310498541708228 0.547641965662978 MirTarget -0.260514614017034 0.00195714760384445 NA NA NA hsa-miR-590-3p RPS6KA6 0.83851360565783 0.00129224433453587 -0.310498541708228 0.547641965662978 MirTarget;miRanda;mirMAP;miRNATAP -0.377977107702572 0.000520704002280122 NA NA NA hsa-miR-708-3p RPS6KA6 3.43841959417743 4.40027692981683e-28 -0.310498541708228 0.547641965662978 MirTarget -0.246540887468603 0.00199652994756385 NA NA NA hsa-miR-96-5p RPS6KA6 3.0381097138467 4.40362891630201e-24 -0.310498541708228 0.547641965662978 MirTarget;TargetScan -0.257070525875399 0.00305783578647258 NA NA NA hsa-miR-1306-3p RRAS 0.128239923662981 0.640502577294429 -1.34967041610552 2.3564515138194e-13 MirTarget -0.127414966107971 0.000110941454747152 NA NA NA hsa-miR-29b-3p RRAS2 3.10527711861309 3.01242507282711e-32 -0.384314789055802 0.0136066111874471 miRNATAP -0.142834477685943 1.31210929655112e-08 NA NA NA hsa-miR-93-5p RRAS2 1.50844106515467 1.83836866996875e-12 -0.384314789055802 0.0136066111874471 miRNAWalker2_validate -0.100240590212887 0.00222620247352813 NA NA NA hsa-miR-181a-5p SOS1 -0.375429731222937 0.0562142867129802 0.0798852744327974 0.432914353979627 MirTarget;miRNATAP -0.10469236503224 9.69385315635354e-06 NA NA NA hsa-miR-26a-2-3p SOS1 0.264287787772609 0.305653616292982 0.0798852744327974 0.432914353979627 mirMAP -0.11755820325968 1.45592951814447e-07 NA NA NA hsa-miR-30b-5p SOS1 0.358144314839612 0.138026229059594 0.0798852744327974 0.432914353979627 mirMAP -0.100738601906088 1.42009312360891e-07 NA NA NA hsa-miR-30c-5p SOS1 -0.327319105755825 0.123595832152687 0.0798852744327974 0.432914353979627 mirMAP;miRNATAP -0.118113245139624 5.71228815703205e-08 NA NA NA hsa-miR-664a-3p SOS1 0.443077463053857 0.0214248925850984 0.0798852744327974 0.432914353979627 mirMAP -0.10862184907092 6.79471781102034e-06 NA NA NA hsa-miR-140-5p STK3 0.669142684153918 0.000335928403032308 0.196207476667763 0.130742624824556 PITA;miRanda -0.128810906746511 8.08502761316053e-05 NA NA NA hsa-miR-342-3p STK3 -0.128691966564961 0.561034080130801 0.196207476667763 0.130742624824556 miRanda -0.136758532944532 3.28789203417708e-07 NA NA NA hsa-miR-30b-5p STK4 0.358144314839612 0.138026229059594 -0.370768525362291 0.00084097936697174 mirMAP -0.109036662468909 2.12140432446357e-07 NA NA NA hsa-miR-664a-3p STK4 0.443077463053857 0.0214248925850984 -0.370768525362291 0.00084097936697174 mirMAP -0.122729592974758 3.54828377283425e-06 NA NA NA hsa-miR-139-5p STMN1 -2.26625553116965 7.22375119369519e-16 0.714015868848262 0.00218062135194851 miRanda -0.238341205866429 5.95492733662296e-11 NA NA NA hsa-miR-26a-5p STMN1 -0.126411409001078 0.440028840408711 0.714015868848262 0.00218062135194851 miRNATAP -0.267772865897944 5.16652843135063e-05 NA NA NA hsa-miR-30a-5p STMN1 -0.924084264430689 0.000762030454634728 0.714015868848262 0.00218062135194851 miRNAWalker2_validate -0.2292229617849 2.60904463969912e-09 NA NA NA hsa-miR-338-3p STMN1 0.726843067232002 0.0506251324215494 0.714015868848262 0.00218062135194851 miRanda -0.166523082135577 5.07575626105215e-09 NA NA NA hsa-let-7a-3p TAOK1 0.167285443861993 0.431834813181487 -0.16111893285224 0.476174522942365 MirTarget;miRNATAP -0.172505134448491 0.00169358772658159 NA NA NA hsa-let-7d-5p TAOK1 -0.618145137285851 6.06067642715858e-05 -0.16111893285224 0.476174522942365 miRNATAP -0.182329442648259 0.00711449966423191 NA NA NA hsa-miR-130a-3p TAOK1 0.881660100597014 0.000158893668519248 -0.16111893285224 0.476174522942365 mirMAP -0.123962137308099 0.00522244549331204 NA NA NA hsa-miR-139-5p TAOK1 -2.26625553116965 7.22375119369519e-16 -0.16111893285224 0.476174522942365 PITA;miRanda;mirMAP;miRNATAP -0.113480218265105 0.00152178207406092 NA NA NA hsa-miR-145-3p TAOK1 -0.68545633476888 0.000680820366475469 -0.16111893285224 0.476174522942365 mirMAP -0.226064579174761 1.01599578409858e-05 NA NA NA hsa-miR-145-5p TAOK1 -1.34926078156437 2.63526538800669e-07 -0.16111893285224 0.476174522942365 MirTarget;miRNATAP -0.139244089481025 0.000371753961337037 NA NA NA hsa-miR-15a-5p TAOK1 1.62575353599172 1.55312121019827e-19 -0.16111893285224 0.476174522942365 MirTarget -0.26418309407881 1.85145514276225e-06 NA NA NA hsa-miR-16-5p TAOK1 0.749619098384047 4.11649450706988e-06 -0.16111893285224 0.476174522942365 MirTarget;miRNATAP -0.19131590424519 0.00271753362742668 NA NA NA hsa-miR-181a-5p TAOK1 -0.375429731222937 0.0562142867129802 -0.16111893285224 0.476174522942365 mirMAP;miRNATAP -0.184426909457002 0.000503722095652086 NA NA NA hsa-miR-181b-5p TAOK1 0.668793269169928 0.000239998092406404 -0.16111893285224 0.476174522942365 mirMAP;miRNATAP -0.161791367048407 0.00464311808588534 NA NA NA hsa-miR-186-5p TAOK1 0.852175445703945 6.88885738584309e-10 -0.16111893285224 0.476174522942365 mirMAP -0.23101169228543 0.00203291361414138 NA NA NA hsa-miR-195-5p TAOK1 -1.01577502605386 4.80814718341729e-05 -0.16111893285224 0.476174522942365 MirTarget -0.197935905374477 4.94050376026822e-06 NA NA NA hsa-miR-199a-5p TAOK1 1.3057193856884 2.38429382751645e-08 -0.16111893285224 0.476174522942365 MirTarget;miRanda;miRNATAP -0.165005536554494 0.000161832579649538 NA NA NA hsa-miR-199b-5p TAOK1 2.13822205171062 4.56262988762436e-15 -0.16111893285224 0.476174522942365 MirTarget;miRanda;miRNATAP -0.142409318677417 0.000111069040437822 NA NA NA hsa-miR-19a-3p TAOK1 2.11776595911517 7.07663078397156e-10 -0.16111893285224 0.476174522942365 MirTarget;miRNATAP -0.124737145395516 0.000429051496488839 NA NA NA hsa-miR-19b-3p TAOK1 2.10868505662119 5.40846613768389e-17 -0.16111893285224 0.476174522942365 MirTarget;miRNATAP -0.131782468506133 0.00173089923833445 NA NA NA hsa-miR-214-3p TAOK1 -1.1136198715556 3.52054933799089e-05 -0.16111893285224 0.476174522942365 miRNATAP -0.156875894174205 4.0641453955141e-05 NA NA NA hsa-miR-222-3p TAOK1 0.0327210697409583 0.881937768109611 -0.16111893285224 0.476174522942365 miRNATAP -0.148489654524579 0.00172149683021123 NA NA NA hsa-miR-26a-2-3p TAOK1 0.264287787772609 0.305653616292982 -0.16111893285224 0.476174522942365 mirMAP -0.292796013356107 3.83449292675209e-09 NA NA NA hsa-miR-26b-5p TAOK1 0.72362441215247 4.7794659748036e-05 -0.16111893285224 0.476174522942365 mirMAP;miRNATAP -0.353290534635655 8.03525098141586e-10 NA NA NA hsa-miR-27b-3p TAOK1 0.236438984240408 0.12263510345883 -0.16111893285224 0.476174522942365 MirTarget -0.259842091428906 0.000146618101040148 NA NA NA hsa-miR-29a-3p TAOK1 0.101650412194573 0.573201097011668 -0.16111893285224 0.476174522942365 mirMAP -0.247189832908288 1.88690519133063e-05 NA NA NA hsa-miR-29a-5p TAOK1 1.89519956688438 1.03453349363915e-11 -0.16111893285224 0.476174522942365 mirMAP -0.216425974615583 5.72516755882671e-07 NA NA NA hsa-miR-29b-2-5p TAOK1 0.345881055247341 0.194842633194187 -0.16111893285224 0.476174522942365 MirTarget -0.120623091364373 0.00198169477533634 NA NA NA hsa-miR-29c-3p TAOK1 1.32354490728858 1.84279305179762e-07 -0.16111893285224 0.476174522942365 mirMAP -0.111836309157672 0.00576179535845996 NA NA NA hsa-miR-30b-5p TAOK1 0.358144314839612 0.138026229059594 -0.16111893285224 0.476174522942365 miRNAWalker2_validate;MirTarget -0.28479011672789 1.69656259237531e-11 NA NA NA hsa-miR-30c-5p TAOK1 -0.327319105755825 0.123595832152687 -0.16111893285224 0.476174522942365 MirTarget;miRNATAP -0.350542569133729 2.64651332527778e-13 NA NA NA hsa-miR-30e-5p TAOK1 1.60414100786743 3.78951090573667e-19 -0.16111893285224 0.476174522942365 MirTarget -0.20200014916548 0.00030009573441599 NA NA NA hsa-miR-324-5p TAOK1 1.06955541886548 5.39722006604758e-05 -0.16111893285224 0.476174522942365 miRanda -0.105070838915208 0.00709749533498749 NA NA NA hsa-miR-339-5p TAOK1 0.536997313601114 0.0488090394176611 -0.16111893285224 0.476174522942365 miRanda -0.136699493410958 0.00032808894806485 NA NA NA hsa-miR-33a-5p TAOK1 2.80127809675219 5.09053890529424e-12 -0.16111893285224 0.476174522942365 mirMAP -0.127792014393064 3.43875030968547e-05 NA NA NA hsa-miR-342-3p TAOK1 -0.128691966564961 0.561034080130801 -0.16111893285224 0.476174522942365 miRanda -0.241244769856949 2.41311371524839e-07 NA NA NA hsa-miR-362-3p TAOK1 0.194097672030785 0.52808475179225 -0.16111893285224 0.476174522942365 miRanda -0.180023026806431 1.90176150661251e-05 NA NA NA hsa-miR-374a-5p TAOK1 -0.197027254874826 0.298080902192861 -0.16111893285224 0.476174522942365 mirMAP -0.258841317051493 2.68740456283067e-05 NA NA NA hsa-miR-424-5p TAOK1 1.26485330287919 6.1498991028257e-06 -0.16111893285224 0.476174522942365 MirTarget -0.125965643510401 0.00061187250327034 NA NA NA hsa-miR-429 TAOK1 2.3794516574089 1.72813419703734e-13 -0.16111893285224 0.476174522942365 MirTarget;mirMAP;miRNATAP -0.118375272462791 0.000480246155890629 NA NA NA hsa-miR-450b-5p TAOK1 1.69248953402469 1.96052058003353e-07 -0.16111893285224 0.476174522942365 MirTarget;PITA;miRNATAP -0.139245023652835 7.39911516091884e-05 NA NA NA hsa-miR-454-3p TAOK1 1.49453641052169 4.46235742871434e-09 -0.16111893285224 0.476174522942365 mirMAP -0.216568100692343 5.90785827431521e-06 NA NA NA hsa-miR-497-5p TAOK1 -0.0546347378264729 0.786205564901684 -0.16111893285224 0.476174522942365 MirTarget -0.245203029481032 1.95845062069903e-06 NA NA NA hsa-miR-501-5p TAOK1 0.411357595674671 0.10435288464149 -0.16111893285224 0.476174522942365 miRNATAP -0.145154600029095 0.00040194443215533 NA NA NA hsa-miR-542-3p TAOK1 1.62226640768239 2.6427102465476e-10 -0.16111893285224 0.476174522942365 miRanda -0.109147963794264 0.00606203404136834 NA NA NA hsa-miR-590-3p TAOK1 0.83851360565783 0.00129224433453587 -0.16111893285224 0.476174522942365 miRanda;mirMAP -0.142400884269459 0.00285490927252627 NA NA NA hsa-miR-664a-3p TAOK1 0.443077463053857 0.0214248925850984 -0.16111893285224 0.476174522942365 mirMAP -0.319252305702804 2.28188426362743e-09 NA NA NA hsa-miR-96-5p TAOK1 3.0381097138467 4.40362891630201e-24 -0.16111893285224 0.476174522942365 miRNAWalker2_validate;TargetScan;miRNATAP -0.158988276392265 2.58939095116732e-05 NA NA NA hsa-miR-99a-5p TAOK1 -0.257323677426697 0.265561868046404 -0.16111893285224 0.476174522942365 MirTarget;miRNATAP -0.123682009906024 0.00616121647868962 NA NA NA hsa-miR-28-5p TAOK2 1.19639196514745 4.59365801666536e-18 -0.457432104631398 9.87540856939123e-05 miRanda -0.1694942749909 8.64257004797067e-06 NA NA NA hsa-miR-769-5p TAOK2 0.399593956787959 0.0122647297786293 -0.457432104631398 9.87540856939123e-05 miRNAWalker2_validate -0.148893924042057 1.24617453439256e-05 NA NA NA hsa-miR-106a-5p TAOK3 1.3902608059488 6.07931522284525e-05 -0.43810473116311 0.000733770172402797 MirTarget -0.128902845338371 6.34993404189099e-12 NA NA NA hsa-miR-106b-5p TAOK3 1.47447672652218 1.32004094930462e-13 -0.43810473116311 0.000733770172402797 MirTarget -0.191399155485756 3.09740486181144e-11 NA NA NA hsa-miR-17-5p TAOK3 2.07078488653279 2.77403038572568e-19 -0.43810473116311 0.000733770172402797 MirTarget;TargetScan -0.22124370355876 2.71817552351662e-20 NA NA NA hsa-miR-18a-5p TAOK3 1.37435209536521 9.2173853686829e-06 -0.43810473116311 0.000733770172402797 miRNATAP -0.203989813171185 4.22152349108591e-25 NA NA NA hsa-miR-193b-3p TAOK3 1.10444771306846 0.000822888533401377 -0.43810473116311 0.000733770172402797 miRNAWalker2_validate -0.10898395658295 8.21866391814071e-10 NA NA NA hsa-miR-19b-1-5p TAOK3 1.71217036351784 3.28561659177495e-12 -0.43810473116311 0.000733770172402797 MirTarget -0.19427910099469 5.04850410831749e-13 NA NA NA hsa-miR-20a-5p TAOK3 2.64649625616975 5.1469418982085e-27 -0.43810473116311 0.000733770172402797 MirTarget -0.162959696499997 3.84504273216327e-13 NA NA NA hsa-miR-429 TAOK3 2.3794516574089 1.72813419703734e-13 -0.43810473116311 0.000733770172402797 MirTarget;PITA;miRanda;miRNATAP -0.117815738692679 9.40678145124393e-10 NA NA NA hsa-miR-93-5p TAOK3 1.50844106515467 1.83836866996875e-12 -0.43810473116311 0.000733770172402797 MirTarget -0.191318035248549 8.53779420179376e-13 NA NA NA hsa-miR-107 TGFB2 0.658676029898313 5.11480446318819e-07 -1.54728695593794 7.69099073313309e-06 miRanda -0.355503342954706 0.0038910869011085 NA NA NA hsa-miR-141-3p TGFB2 3.36993755486106 5.42939251147195e-32 -1.54728695593794 7.69099073313309e-06 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.398731446418857 4.7542493450425e-15 NA NA NA hsa-miR-142-3p TGFB2 3.98476449801341 1.56256182021111e-35 -1.54728695593794 7.69099073313309e-06 miRNATAP -0.187445508387807 4.91415161970629e-05 NA NA NA hsa-miR-148a-3p TGFB2 2.30885799126944 1.95226081368985e-21 -1.54728695593794 7.69099073313309e-06 MirTarget;miRNATAP -0.318993015839907 3.72194712163796e-07 NA NA NA hsa-miR-148b-3p TGFB2 0.483970528590224 0.0026495409465901 -1.54728695593794 7.69099073313309e-06 MirTarget -0.597854798049066 1.54973691719479e-09 NA NA NA hsa-miR-186-5p TGFB2 0.852175445703945 6.88885738584309e-10 -1.54728695593794 7.69099073313309e-06 mirMAP -0.409008453141581 0.000403399259315524 NA NA NA hsa-miR-193b-3p TGFB2 1.10444771306846 0.000822888533401377 -1.54728695593794 7.69099073313309e-06 MirTarget;miRNATAP -0.171701127106121 0.000381178774316089 NA NA NA hsa-miR-200a-3p TGFB2 3.14766878548496 1.32850889777422e-21 -1.54728695593794 7.69099073313309e-06 MirTarget;miRNATAP -0.154438122204007 0.00120018739162872 25813153 Tumor suppressive microRNA 200a inhibits renal cell carcinoma development by directly targeting TGFB2; By performing quantitative real-time PCR ELISA and luciferase reporter assays transforming growth factor beta2 TGFB2 was validated as a direct target gene of miR-200a; Moreover siRNA-mediated knockdown of TGFB2 partially phenocopied the effect of miR-200a overexpression; These results suggest that miR-200a suppresses RCC development via directly targeting TGFB2 indicating that miR-200a may present a novel target for diagnostic and therapeutic strategies in RCC kidney renal cell cancer hsa-miR-203a-3p TGFB2 1.06866854356847 0.00389979689199624 -1.54728695593794 7.69099073313309e-06 MirTarget -0.12742735196134 0.0031970050420777 NA NA NA hsa-miR-21-5p TGFB2 4.38165933891779 1.52536633902505e-92 -1.54728695593794 7.69099073313309e-06 miRNAWalker2_validate -0.232847735640903 0.000134967329541337 NA NA NA hsa-miR-29b-3p TGFB2 3.10527711861309 3.01242507282711e-32 -1.54728695593794 7.69099073313309e-06 miRTarBase;MirTarget;miRNATAP -0.323475743722128 9.24598069519868e-09 NA NA NA hsa-miR-301a-3p TGFB2 2.70198002906399 1.56420889710984e-14 -1.54728695593794 7.69099073313309e-06 MirTarget;miRNATAP -0.16074364225942 0.003487243350105 NA NA NA hsa-miR-324-5p TGFB2 1.06955541886548 5.39722006604758e-05 -1.54728695593794 7.69099073313309e-06 miRanda -0.277999824516596 3.4653275853172e-06 NA NA NA hsa-miR-330-5p TGFB2 0.168520831101569 0.336433937906706 -1.54728695593794 7.69099073313309e-06 miRanda -0.295257890261626 0.00139702498209663 NA NA NA hsa-miR-335-3p TGFB2 1.51116383169018 6.88553098788624e-13 -1.54728695593794 7.69099073313309e-06 mirMAP -0.356021240436402 1.58351764723679e-06 NA NA NA hsa-miR-375 TGFB2 0.615547997686534 0.149199273675144 -1.54728695593794 7.69099073313309e-06 miRNAWalker2_validate -0.199582093308253 8.10520720431323e-08 NA NA NA hsa-miR-454-3p TGFB2 1.49453641052169 4.46235742871434e-09 -1.54728695593794 7.69099073313309e-06 MirTarget;miRNATAP -0.278722444132023 0.000172215670429774 NA NA NA hsa-miR-589-3p TGFB2 1.34253876396688 1.84935927493927e-05 -1.54728695593794 7.69099073313309e-06 MirTarget -0.136277206270106 0.00952077915925194 NA NA NA hsa-miR-590-3p TGFB2 0.83851360565783 0.00129224433453587 -1.54728695593794 7.69099073313309e-06 mirMAP -0.246860466689251 0.000814615379526392 NA NA NA hsa-miR-590-5p TGFB2 2.07441240363458 4.95240551694843e-14 -1.54728695593794 7.69099073313309e-06 miRanda;miRNATAP -0.326100319483825 3.24920581765168e-06 NA NA NA hsa-miR-151a-5p TGFB3 1.23124135275661 2.93488020257558e-12 -0.422252931437748 0.0394980941232173 MirTarget -0.160744804451189 0.00224479945628548 NA NA NA hsa-miR-181a-5p TGFBR1 -0.375429731222937 0.0562142867129802 -0.167191366180853 0.27609922306653 mirMAP;miRNATAP -0.111893127985776 0.00187864554318442 NA NA NA hsa-miR-181b-5p TGFBR1 0.668793269169928 0.000239998092406404 -0.167191366180853 0.27609922306653 mirMAP;miRNATAP -0.106118594458465 0.00618830848725763 NA NA NA hsa-miR-186-5p TGFBR1 0.852175445703945 6.88885738584309e-10 -0.167191366180853 0.27609922306653 mirMAP -0.186046735019657 0.000240151436081305 NA NA NA hsa-miR-301a-3p TGFBR1 2.70198002906399 1.56420889710984e-14 -0.167191366180853 0.27609922306653 miRNATAP -0.127251998150772 9.77464856526446e-08 NA NA NA hsa-miR-339-5p TGFBR1 0.536997313601114 0.0488090394176611 -0.167191366180853 0.27609922306653 miRanda -0.10996653528395 1.92059453349486e-05 NA NA NA hsa-miR-454-3p TGFBR1 1.49453641052169 4.46235742871434e-09 -0.167191366180853 0.27609922306653 mirMAP;miRNATAP -0.189224937093636 4.08118068619792e-09 NA NA NA hsa-miR-500a-5p TGFBR1 0.648155655714409 0.0104657432932038 -0.167191366180853 0.27609922306653 mirMAP -0.114024018807088 6.20777757370005e-05 NA NA NA hsa-miR-590-5p TGFBR1 2.07441240363458 4.95240551694843e-14 -0.167191366180853 0.27609922306653 PITA;miRanda -0.10044599216345 0.00115082407675084 NA NA NA hsa-miR-664a-3p TGFBR1 0.443077463053857 0.0214248925850984 -0.167191366180853 0.27609922306653 mirMAP -0.121722345860296 0.000910606813958885 NA NA NA hsa-miR-96-5p TGFBR1 3.0381097138467 4.40362891630201e-24 -0.167191366180853 0.27609922306653 TargetScan;miRNATAP -0.122213570914045 1.7309565646113e-06 NA NA NA hsa-miR-106a-5p TGFBR2 1.3902608059488 6.07931522284525e-05 -1.91514811101753 8.06244385153145e-21 miRTarBase;miRNATAP -0.307299619778838 1.05077186229689e-24 22912877 MiR-106a inhibits the expression of transforming growth factor-β receptor 2 TGFBR2 leading to increased CRC cell migration and invasion cell migration colorectal cancer hsa-miR-106b-5p TGFBR2 1.47447672652218 1.32004094930462e-13 -1.91514811101753 8.06244385153145e-21 miRNATAP -0.489829180282667 8.40946965796872e-27 NA NA NA hsa-miR-107 TGFBR2 0.658676029898313 5.11480446318819e-07 -1.91514811101753 8.06244385153145e-21 miRanda;miRNATAP -0.249662024836709 0.000915438458167535 NA NA NA hsa-miR-130a-3p TGFBR2 0.881660100597014 0.000158893668519248 -1.91514811101753 8.06244385153145e-21 miRNATAP -0.133524786080657 0.00147048710917249 NA NA NA hsa-miR-130b-3p TGFBR2 1.83046548750752 5.04753914574694e-13 -1.91514811101753 8.06244385153145e-21 miRNAWalker2_validate;miRNATAP -0.421734905263531 3.34337229820852e-29 25024357 Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC lung squamous cell cancer hsa-miR-142-3p TGFBR2 3.98476449801341 1.56256182021111e-35 -1.91514811101753 8.06244385153145e-21 miRanda -0.187481539830466 1.6656456255275e-11 NA NA NA hsa-miR-17-5p TGFBR2 2.07078488653279 2.77403038572568e-19 -1.91514811101753 8.06244385153145e-21 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.459908602342412 2.77212111529676e-33 25011053;27120811 We demonstrate that miR-17 overexpression interferes with the TGFβ-EMT axis and hinders RCC sphere formation; and validated TGFBR2 as a direct and biologically relevant target during this process;MiR-17-5p was found to bind to the 3'UTR of TGFBR2 mRNA and further validation of this specific binding was performed through a reporter assay; An inverse correlation between miR-17-5p and TGFBR2 protein was observed in gastric cancer tissues; Cell studies revealed that miR-17-5p negatively regulated TGFBR2 expression by directly binding to the 3'UTR of TGFBR2 mRNA thereby promoting cell growth and migration; The results of our study suggest a novel regulatory network in gastric cancer mediated by miR-17-5p and TGFBR2 and may indicate that TGFBR2 could serve as a new therapeutic target in gastric cancer ; kidney renal cell cancer;gastric cancer hsa-miR-186-5p TGFBR2 0.852175445703945 6.88885738584309e-10 -1.91514811101753 8.06244385153145e-21 miRNATAP -0.37798394554975 7.20570520945192e-08 NA NA NA hsa-miR-18a-5p TGFBR2 1.37435209536521 9.2173853686829e-06 -1.91514811101753 8.06244385153145e-21 miRNAWalker2_validate -0.38653356233861 4.47853283994857e-34 NA NA NA hsa-miR-19a-3p TGFBR2 2.11776595911517 7.07663078397156e-10 -1.91514811101753 8.06244385153145e-21 miRNAWalker2_validate;miRNATAP -0.323482765468371 5.08943605092696e-24 NA NA NA hsa-miR-19b-3p TGFBR2 2.10868505662119 5.40846613768389e-17 -1.91514811101753 8.06244385153145e-21 miRNAWalker2_validate;miRNATAP -0.328250904264368 1.63625661417425e-17 NA NA NA hsa-miR-20a-5p TGFBR2 2.64649625616975 5.1469418982085e-27 -1.91514811101753 8.06244385153145e-21 miRNAWalker2_validate;miRTarBase;miRNATAP -0.375686915628948 1.07150885156846e-25 NA NA NA hsa-miR-20b-5p TGFBR2 1.35770573270947 0.00260808530013016 -1.91514811101753 8.06244385153145e-21 miRNATAP -0.192278018490753 3.46305290056928e-18 NA NA NA hsa-miR-21-5p TGFBR2 4.38165933891779 1.52536633902505e-92 -1.91514811101753 8.06244385153145e-21 miRNAWalker2_validate;miRTarBase;miRNATAP -0.29338269527103 7.25339608661878e-16 24037531 Androgen receptor and microRNA 21 axis downregulates transforming growth factor beta receptor II TGFBR2 expression in prostate cancer; Our results revealed that miR-21 suppresses TGFBR2 levels by binding to its 3'-UTR and AR signaling further potentiates this effect in both untransformed and transformed human prostate epithelial cells as well as in human prostate cancers; Manipulation of androgen signaling or the expression levels of AR or miR-21 negatively altered TGFBR2 expression in untransformed and transformed human prostate epithelial cells human prostate cancer xenografts and mouse prostate glands; Together these results suggest that the AR and miR-21 axis exerts its oncogenic effects in prostate tumors by downregulating TGFBR2 hence inhibiting the tumor-suppressive activity of TGFβ pathway prostate cancer hsa-miR-28-5p TGFBR2 1.19639196514745 4.59365801666536e-18 -1.91514811101753 8.06244385153145e-21 miRanda -0.254315455087218 0.000247518782921618 NA NA NA hsa-miR-301a-3p TGFBR2 2.70198002906399 1.56420889710984e-14 -1.91514811101753 8.06244385153145e-21 miRNATAP -0.306940704751146 1.9075182777364e-21 25551793 MicroRNA 301a promotes migration and invasion by targeting TGFBR2 in human colorectal cancer; TGFBR2 was identified to be the downstream target of miR-301a; Knockdown of TGFBR2 in cells treated by miR-301a inhibitor elevated the previously abrogated migration and invasion; Our data indicated that miR-301a correlated with the metastatic and invasive ability in human colorectal cancers and miR-301a exerted its role as oncogene by targeting TGFBR2 colorectal cancer hsa-miR-320b TGFBR2 0.226640952564488 0.378818692487242 -1.91514811101753 8.06244385153145e-21 miRanda;miRNATAP -0.165151125825337 1.46846956764834e-05 NA NA NA hsa-miR-335-3p TGFBR2 1.51116383169018 6.88553098788624e-13 -1.91514811101753 8.06244385153145e-21 mirMAP -0.311492404920043 3.63496852087191e-12 NA NA NA hsa-miR-429 TGFBR2 2.3794516574089 1.72813419703734e-13 -1.91514811101753 8.06244385153145e-21 miRNATAP -0.181653865770588 1.06914381055553e-08 NA NA NA hsa-miR-454-3p TGFBR2 1.49453641052169 4.46235742871434e-09 -1.91514811101753 8.06244385153145e-21 miRNATAP -0.388080867072043 1.00998271677092e-18 NA NA NA hsa-miR-590-3p TGFBR2 0.83851360565783 0.00129224433453587 -1.91514811101753 8.06244385153145e-21 miRanda -0.298621103008163 1.65211510727765e-11 NA NA NA hsa-miR-590-5p TGFBR2 2.07441240363458 4.95240551694843e-14 -1.91514811101753 8.06244385153145e-21 miRNAWalker2_validate;miRTarBase;PITA;miRanda;miRNATAP -0.431767389541112 5.30215312039448e-26 NA NA NA hsa-miR-9-5p TGFBR2 4.99250901331516 2.59132733422801e-19 -1.91514811101753 8.06244385153145e-21 miRNATAP -0.172577947355941 5.13696472146911e-27 25024357 Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC lung squamous cell cancer hsa-miR-92a-3p TGFBR2 -0.136362762339122 0.493412263619364 -1.91514811101753 8.06244385153145e-21 miRNAWalker2_validate -0.23924023089002 1.25343457467846e-06 NA NA NA hsa-miR-93-5p TGFBR2 1.50844106515467 1.83836866996875e-12 -1.91514811101753 8.06244385153145e-21 miRNAWalker2_validate;miRNATAP -0.466353393701927 4.52770573714137e-28 NA NA NA hsa-miR-107 TNF 0.658676029898313 5.11480446318819e-07 -0.830982767486341 0.0138827131679617 miRanda -0.439603202171767 0.000221374639268502 NA NA NA hsa-miR-429 TNF 2.3794516574089 1.72813419703734e-13 -0.830982767486341 0.0138827131679617 miRNATAP -0.135544464882007 0.00782170177882693 NA NA NA hsa-miR-140-3p TRAF2 -1.11373309124537 8.35257079443689e-14 1.00807946070122 6.3314135046518e-09 MirTarget -0.244688143587184 4.1120893831993e-06 NA NA NA hsa-miR-146b-5p TRAF6 1.0922867893808 5.63754607494775e-06 -0.570488019182001 1.31779124902099e-08 miRNAWalker2_validate;MirTarget;PITA;miRanda;miRNATAP -0.103141555868294 6.11468978472721e-08 NA NA NA hsa-miR-15a-5p TRAF6 1.62575353599172 1.55312121019827e-19 -0.570488019182001 1.31779124902099e-08 MirTarget -0.164265949211244 2.39073737876917e-11 NA NA NA