miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-155-5p ACADSB 0.0108524225071784 0.95651331033505 -2.10604065735705 5.36295714659088e-25 mirMAP -0.273936089576981 1.86144415297911e-07 NA NA NA hsa-miR-155-5p ACSL6 0.0108524225071784 0.95651331033505 0.391527588368073 0.264580316303862 mirMAP -0.390255884675669 4.86895242221466e-06 NA NA NA hsa-miR-155-5p ADH5 0.0108524225071784 0.95651331033505 -0.526265133969334 4.16084065599943e-07 miRNAWalker2_validate -0.138037021567834 5.89735403746562e-08 NA NA NA hsa-miR-155-5p AGL 0.0108524225071784 0.95651331033505 -1.73607796182928 2.6624035837235e-30 miRNAWalker2_validate -0.155368439280222 9.89684053601108e-05 NA NA NA hsa-miR-155-5p ALDH3A2 0.0108524225071784 0.95651331033505 -0.549782198205341 0.000215333966024332 miRNAWalker2_validate;mirMAP -0.256980068550245 6.19045618041919e-13 NA NA NA hsa-miR-155-5p ALDH5A1 0.0108524225071784 0.95651331033505 -1.10134059033742 2.89516754967917e-11 miRNAWalker2_validate -0.319405687373522 2.1646146215853e-15 NA NA NA hsa-miR-155-5p ALDH9A1 0.0108524225071784 0.95651331033505 -1.01814226259694 6.41059584460379e-18 miRNAWalker2_validate -0.186981180276812 2.605908693015e-10 NA NA NA hsa-miR-155-5p ANPEP 0.0108524225071784 0.95651331033505 -0.914605441330613 4.19025373805737e-07 miRNAWalker2_validate -0.15568303502288 0.000513325060834501 NA NA NA hsa-miR-155-5p AQP4 0.0108524225071784 0.95651331033505 -2.60269555649257 1.10014775225101e-10 mirMAP -0.202198165754866 0.0464599898224561 NA NA NA hsa-miR-155-5p AR 0.0108524225071784 0.95651331033505 -2.65514434874701 6.79656050811819e-11 mirMAP -0.468989744150432 3.77409172012017e-06 NA NA NA hsa-miR-155-5p ARHGAP32 0.0108524225071784 0.95651331033505 -0.199023023372693 0.099211320915758 mirMAP -0.194205178029023 1.85513424222417e-11 NA NA NA hsa-miR-155-5p ARHGAP5 0.0108524225071784 0.95651331033505 -0.390501975399923 8.01729872271933e-05 mirMAP -0.106689067532435 1.07117354005012e-05 NA NA NA hsa-miR-155-5p ARNTL 0.0108524225071784 0.95651331033505 -0.353592991763437 0.0233136973382113 miRNATAP -0.113314035017924 0.00304870220932244 NA NA NA hsa-miR-155-5p ATL2 0.0108524225071784 0.95651331033505 -0.0961038265935708 0.239507878733616 miRNAWalker2_validate -0.133440470868652 7.24711635545414e-12 NA NA NA hsa-miR-155-5p ATPAF1 0.0108524225071784 0.95651331033505 -0.624267786463291 3.44529913281597e-12 miRNAWalker2_validate -0.105984125195766 2.0770081965034e-06 NA NA NA hsa-miR-155-5p BRPF3 0.0108524225071784 0.95651331033505 0.347912163638623 0.00299376429932645 miRNAWalker2_validate;miRTarBase -0.149201977836325 1.59315826332539e-07 NA NA NA hsa-miR-155-5p BRWD1 0.0108524225071784 0.95651331033505 -0.472319203635839 2.18876455365102e-07 mirMAP -0.114289654068219 3.1694132473255e-07 NA NA NA hsa-miR-155-5p C3orf18 0.0108524225071784 0.95651331033505 0.570791050542465 0.000139633927770441 miRNATAP -0.11816616079806 0.00137811256425946 NA NA NA hsa-miR-15a-5p CAB39 0.349521211668244 0.000770735998804736 -0.152804524606349 0.00962811714746276 miRNATAP -0.108425253583809 7.85731490720904e-05 NA NA NA hsa-miR-16-1-3p CAB39 0.392360028038559 0.00112481918108198 -0.152804524606349 0.00962811714746276 MirTarget -0.117268659952457 5.98270638213691e-07 NA NA NA hsa-miR-193a-3p CAB39 -0.117675551589896 0.309391958208578 -0.152804524606349 0.00962811714746276 MirTarget;miRanda -0.123942945247746 4.68902843877997e-07 NA NA NA hsa-miR-155-5p CAT 0.0108524225071784 0.95651331033505 -1.65049060277008 8.91987155536677e-23 miRNAWalker2_validate -0.252501537109049 3.74321469375588e-09 NA NA NA hsa-miR-155-5p CBR4 0.0108524225071784 0.95651331033505 -1.37669382270307 4.66233042027365e-22 miRNAWalker2_validate -0.179822451780224 8.30310481331181e-07 NA NA NA hsa-miR-155-5p CD36 0.0108524225071784 0.95651331033505 -0.220055913595622 0.390337953161077 miRNAWalker2_validate -0.13053524547263 0.0380042452319237 NA NA NA hsa-miR-155-5p CDC42EP4 0.0108524225071784 0.95651331033505 0.246207215190545 0.00876374992456772 MirTarget -0.12390761548148 4.94353757024574e-08 NA NA NA hsa-miR-155-5p CDK5RAP3 0.0108524225071784 0.95651331033505 0.709071886172995 5.18608879920515e-13 miRNAWalker2_validate -0.113260004959011 3.90547470743571e-06 NA NA NA hsa-miR-421 CEBPB 0.941856334694081 6.12167297054077e-08 -0.564778939834119 4.48593604081699e-05 miRNAWalker2_validate;PITA;miRanda -0.233553194489211 7.62368742350427e-10 NA NA NA hsa-miR-423-5p CEBPB 0.698807775906485 1.02195196334612e-11 -0.564778939834119 4.48593604081699e-05 miRNAWalker2_validate;miRNATAP -0.354232988344863 3.41457316367597e-08 NA NA NA hsa-miR-155-5p CFL2 0.0108524225071784 0.95651331033505 -1.18046432826413 1.44423082204062e-19 miRNAWalker2_validate -0.152163373725222 4.64370814736779e-06 NA NA NA hsa-miR-155-5p CLDN1 0.0108524225071784 0.95651331033505 -0.927580437383053 2.58550380636905e-07 miRNAWalker2_validate;miRTarBase -0.128166512829414 0.00420429597684961 23523916;23588589 MicroRNA 155 is a novel suppressor of ovarian cancer initiating cells that targets CLDN1; Here we show that the downregulation of miR-155 in OCICs correlates with CLDN1 overexpression and the suppression of OCIC invasion; Luciferase assays indicate that miR-155 targets CLDN1 mRNA on the 3' UTR; Thus overexpression of miR-155 may prevent tumorigenesis in human ovarian cancer through downregulation of CLDN1;Upregulation of microRNA 155 promotes the migration and invasion of colorectal cancer cells through the regulation of claudin 1 expression; Furthermore the overexpression of miR-155 upregulated claudin-1 expression; Thus our data suggest that miR-155 plays an important role in promoting CRC cell migration and invasion at least in part through the regulation of claudin-1 expression and controlling metastasis in CRC tumorigenesis;metastasis;cell migration ovarian cancer;colorectal cancer hsa-miR-155-5p CNNM3 0.0108524225071784 0.95651331033505 -0.238086405883339 0.0090461385829132 miRNAWalker2_validate -0.195186170648624 6.70405829310711e-20 NA NA NA hsa-miR-155-5p COBLL1 0.0108524225071784 0.95651331033505 -1.47196788797961 8.44363885667744e-17 mirMAP -0.285814643899103 9.95706652595906e-11 NA NA NA hsa-miR-155-5p CPEB4 0.0108524225071784 0.95651331033505 -1.06097838176943 9.01316045116939e-14 mirMAP -0.166681755457063 3.00184489898294e-06 NA NA NA hsa-miR-155-5p CPT1A 0.0108524225071784 0.95651331033505 -0.733211057699249 5.36000577285737e-07 miRNAWalker2_validate -0.169775599618963 2.43115989490253e-06 NA NA NA hsa-miR-155-5p CRAT 0.0108524225071784 0.95651331033505 -0.759647322796027 2.50053417206149e-11 miRNAWalker2_validate -0.15163134409813 7.66452688655382e-08 NA NA NA hsa-miR-155-5p CTAGE5 0.0108524225071784 0.95651331033505 -0.709575649284992 2.3638342970756e-12 miRNAWalker2_validate -0.188389287870193 2.41199761790287e-14 NA NA NA hsa-miR-155-5p CUTA 0.0108524225071784 0.95651331033505 0.574767962106315 1.09952891495435e-06 miRNAWalker2_validate -0.11611689258908 6.61276835924367e-05 NA NA NA hsa-miR-155-5p CUX1 0.0108524225071784 0.95651331033505 -0.187927348104609 0.0398134377996123 miRNAWalker2_validate -0.100398402794727 6.08514182820521e-06 NA NA NA hsa-miR-155-5p CYP51A1 0.0108524225071784 0.95651331033505 -0.0101335191198029 0.944135376921808 miRNAWalker2_validate -0.16462830265234 2.69945834151281e-06 NA NA NA hsa-miR-155-5p DAG1 0.0108524225071784 0.95651331033505 0.137874489007291 0.113958261991147 miRNAWalker2_validate -0.102576567505667 1.17401767927624e-06 NA NA NA hsa-miR-155-5p DCUN1D4 0.0108524225071784 0.95651331033505 -0.241051443609763 0.00351891274628995 miRNATAP -0.127250116385503 1.42137561196293e-10 NA NA NA hsa-miR-155-5p DDI2 0.0108524225071784 0.95651331033505 -1.53096229477393 2.81259482387215e-06 mirMAP -0.240955108946813 0.00296288136464357 NA NA NA hsa-miR-155-5p DHCR24 0.0108524225071784 0.95651331033505 -0.296400686970518 0.02120923867843 miRNAWalker2_validate -0.138577621072915 9.77215549771201e-06 NA NA NA hsa-miR-155-5p DHX40 0.0108524225071784 0.95651331033505 -0.118232522860019 0.195443271490095 miRNAWalker2_validate;miRTarBase;MirTarget -0.125044446718283 1.28228307583977e-08 NA NA NA hsa-miR-155-5p DMD 0.0108524225071784 0.95651331033505 -1.6618166260325 2.70344741582688e-17 miRNAWalker2_validate -0.173318755367886 0.000535142906995194 NA NA NA hsa-miR-155-5p DNAJC19 0.0108524225071784 0.95651331033505 -0.304663504582098 0.00148105847502355 miRNAWalker2_validate -0.172134988301234 5.20103468747769e-14 NA NA NA hsa-miR-155-5p EBF3 0.0108524225071784 0.95651331033505 1.73730919764558 2.69401589893511e-14 mirMAP -0.135115932259522 0.0196787043105042 NA NA NA hsa-miR-155-5p EGFR 0.0108524225071784 0.95651331033505 -1.01672920195188 6.69873186671412e-07 miRNAWalker2_validate;MirTarget -0.128466970088693 0.0115801509528144 NA NA NA hsa-miR-155-5p ELL2 0.0108524225071784 0.95651331033505 -0.765981836031949 3.63519932659754e-07 miRNATAP -0.117887545745684 0.00160726603559119 NA NA NA hsa-miR-155-5p ETNK2 0.0108524225071784 0.95651331033505 -1.42301778283554 7.52967048096134e-07 miRNATAP -0.370269279556415 1.61246926907578e-07 NA NA NA hsa-miR-10b-3p ETS1 2.77189254628215 2.26687582932628e-20 -0.888146453921594 7.30600721510989e-10 mirMAP -0.105519293114893 1.58415058877614e-05 NA NA NA hsa-miR-1180-3p ETS1 1.13535217859875 1.17286173228245e-09 -0.888146453921594 7.30600721510989e-10 MirTarget -0.293265031973102 8.05459469251981e-16 NA NA NA hsa-miR-130b-5p ETS1 0.170599813152408 0.337611586432771 -0.888146453921594 7.30600721510989e-10 MirTarget -0.117830624648738 0.00350746127707538 NA NA NA hsa-miR-148b-5p ETS1 0.295777213389605 0.0255749859535438 -0.888146453921594 7.30600721510989e-10 MirTarget -0.14433424168597 0.00795478698949807 NA NA NA hsa-miR-16-1-3p ETS1 0.392360028038559 0.00112481918108198 -0.888146453921594 7.30600721510989e-10 MirTarget -0.14163124063757 0.0176332220270728 NA NA NA hsa-miR-186-5p ETS1 -0.060103391373687 0.535288717081205 -0.888146453921594 7.30600721510989e-10 mirMAP -0.15329403808341 0.0411464992332332 NA NA NA hsa-miR-193a-3p ETS1 -0.117675551589896 0.309391958208578 -0.888146453921594 7.30600721510989e-10 miRanda;miRNATAP -0.206450097116881 0.000921512501112203 NA NA NA hsa-miR-221-3p ETS1 1.12244756358612 3.48370308238012e-13 -0.888146453921594 7.30600721510989e-10 miRTarBase;miRNATAP -0.163620716574743 0.000282330030340872 21711453 To close the loop we demonstrate ETS-1 as a direct target of miR-222 but not miR-221 showing the novel option of their uncoupled functions melanoma hsa-miR-222-3p ETS1 1.08574156066353 1.76407192348131e-11 -0.888146453921594 7.30600721510989e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.114027687122358 0.00860678284178252 21711453 Constitutive activation of the ETS 1 miR 222 circuitry in metastatic melanoma; We demonstrate that the proto-oncogene ETS-1 involved in the pathogenesis of cancers of different origin is a transcriptional regulator of miR-222 by direct binding to its promoter region; Differently from 293FT cells or early stage melanomas where unphosphorylated ETS-1 represses miR-222 transcription in metastatic melanoma the constitutively Thr-38 phosphorylated fraction of ETS-1 induces miR-222; To close the loop we demonstrate ETS-1 as a direct target of miR-222 but not miR-221 showing the novel option of their uncoupled functions staging melanoma hsa-miR-30d-3p ETS1 -0.120562286038759 0.329549534782125 -0.888146453921594 7.30600721510989e-10 mirMAP -0.123711965263521 0.0344163749253352 NA NA NA hsa-miR-362-3p ETS1 0.814007335895913 2.00108618836568e-09 -0.888146453921594 7.30600721510989e-10 miRanda -0.181573270953595 0.000463194817826299 NA NA NA hsa-miR-365a-3p ETS1 0.164591326307714 0.15325084963213 -0.888146453921594 7.30600721510989e-10 MirTarget -0.267990900609134 1.68132949421869e-05 NA NA NA hsa-miR-421 ETS1 0.941856334694081 6.12167297054077e-08 -0.888146453921594 7.30600721510989e-10 miRanda;mirMAP;miRNATAP -0.204100092132273 4.23645182774089e-07 NA NA NA hsa-miR-455-5p ETS1 -0.270546034117157 0.0581320703577731 -0.888146453921594 7.30600721510989e-10 MirTarget;PITA;miRanda;miRNATAP -0.234313961624189 2.69025876931775e-06 NA NA NA hsa-miR-501-5p ETS1 1.15231083477882 2.98906150004088e-10 -0.888146453921594 7.30600721510989e-10 mirMAP -0.10302951257088 0.00734880104767461 NA NA NA hsa-miR-502-5p ETS1 0.892373335336396 1.7122694518919e-06 -0.888146453921594 7.30600721510989e-10 miRNATAP -0.110285767636931 0.00447567568456658 NA NA NA hsa-miR-532-3p ETS1 0.297601533259956 0.014632205884815 -0.888146453921594 7.30600721510989e-10 MirTarget;PITA;miRNATAP -0.287398076993315 8.8786296594351e-07 NA NA NA hsa-miR-590-5p ETS1 -0.103355559980404 0.310027295317092 -0.888146453921594 7.30600721510989e-10 miRanda -0.359124442253989 3.41545113201445e-07 NA NA NA hsa-miR-660-5p ETS1 0.989755850734071 5.69930767464937e-14 -0.888146453921594 7.30600721510989e-10 MirTarget -0.254076650434129 1.2827423637958e-06 NA NA NA hsa-miR-769-5p ETS1 0.219661452072771 0.0333425465750576 -0.888146453921594 7.30600721510989e-10 miRNATAP -0.213050530713541 0.00233319206600267 NA NA NA hsa-miR-940 ETS1 0.453020092551484 0.0177054921651997 -0.888146453921594 7.30600721510989e-10 MirTarget;miRNATAP -0.152992991185501 6.8236118996806e-05 NA NA NA hsa-miR-155-5p F5 0.0108524225071784 0.95651331033505 -0.326925679296005 0.130648550867534 miRNAWalker2_validate -0.314554647488659 1.62081099573275e-09 NA NA NA hsa-miR-155-5p FAM114A1 0.0108524225071784 0.95651331033505 -0.535044401555146 0.000661785559182086 mirMAP -0.106043180266284 0.00618358915282872 NA NA NA hsa-miR-155-5p FAM177A1 0.0108524225071784 0.95651331033505 -0.352808163601376 0.000237300634881866 miRNAWalker2_validate -0.108371983310404 3.74449726688423e-06 NA NA NA hsa-miR-155-5p FAM8A1 0.0108524225071784 0.95651331033505 -0.45284131007862 0.00119725011194704 mirMAP -0.246246835656398 1.91075691488208e-13 NA NA NA hsa-miR-155-5p FGD4 0.0108524225071784 0.95651331033505 -1.15544171645474 1.45947973849956e-12 mirMAP -0.220210232455343 5.97915791109368e-08 NA NA NA hsa-miR-155-5p FKBP5 0.0108524225071784 0.95651331033505 -0.232073250029758 0.19420333201796 mirMAP -0.142609809021301 0.0011108421856473 NA NA NA hsa-miR-155-5p FZD5 0.0108524225071784 0.95651331033505 -0.369296645507686 0.00193987461810255 miRNATAP -0.108901572202147 0.000190892447770734 NA NA NA hsa-miR-155-5p GABARAPL1 0.0108524225071784 0.95651331033505 -1.45937011735075 1.4980650468657e-15 miRNAWalker2_validate -0.249485069759207 5.49987985349712e-08 NA NA NA hsa-miR-155-5p GATM 0.0108524225071784 0.95651331033505 -1.67872610104551 6.33871234809562e-13 miRNAWalker2_validate -0.246543829782644 2.58088254749154e-05 NA NA NA hsa-miR-155-5p GCLC 0.0108524225071784 0.95651331033505 -0.755917589727378 4.65420685617093e-08 miRNAWalker2_validate -0.198322504330817 4.97718164288822e-09 NA NA NA hsa-miR-155-5p GFRA1 0.0108524225071784 0.95651331033505 -2.5486406119615 2.43457108723549e-08 mirMAP -0.314525969586893 0.00583043818378157 NA NA NA hsa-miR-155-5p GLUL 0.0108524225071784 0.95651331033505 0.444046234271983 0.126185814713881 MirTarget -0.340312529190074 1.42528796297979e-06 NA NA NA hsa-miR-155-5p GPAM 0.0108524225071784 0.95651331033505 -0.472844151955403 0.0637965177079971 miRNAWalker2_validate -0.330322039393616 9.25867845117589e-08 NA NA NA hsa-miR-155-5p GPT2 0.0108524225071784 0.95651331033505 -1.47837181761299 2.51321907474729e-09 miRNAWalker2_validate -0.291999394487911 2.06082508109245e-06 NA NA NA hsa-miR-155-5p GTPBP10 0.0108524225071784 0.95651331033505 -0.208858907279597 0.0121408412268073 mirMAP -0.11411807561284 1.32947318677323e-08 NA NA NA hsa-miR-155-5p HBP1 0.0108524225071784 0.95651331033505 -0.357103377571568 1.81649948774568e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.143975551340643 6.18534411309316e-13 25666090 miR 155 promotes the growth of osteosarcoma in a HBP1 dependent mechanism; HMG-box transcription factor 1 HBP1 a strong Wnt pathway suppressor was found to be a target of miR-155; Restoration of HBP1 abolished the effect of miR-155 on OS cells sarcoma hsa-miR-107 HIF1A 0.241662461253461 0.0170788899505389 -0.366176828296648 0.0111002186054683 miRNAWalker2_validate;miRTarBase;miRanda -0.436710343430652 2.03313957855482e-10 NA NA NA hsa-miR-17-5p HIF1A 0.698861147045461 2.43854106455398e-05 -0.366176828296648 0.0111002186054683 miRTarBase;MirTarget;TargetScan -0.207486649592262 6.73419034465465e-07 NA NA NA hsa-miR-20a-5p HIF1A 0.854326758727003 5.04256669663285e-07 -0.366176828296648 0.0111002186054683 miRNAWalker2_validate;miRTarBase;MirTarget -0.245558453559623 9.83134714947215e-10 22901144 Correlation analysis showed that the key miRNAs miR-20a and miR-20b negatively correlated with the target proteins VEGF-A and HIF-1alpha breast cancer hsa-miR-33a-5p HIF1A -0.767474460958522 1.09948756118522e-05 -0.366176828296648 0.0111002186054683 miRNAWalker2_validate -0.107227499920455 0.00730487730363833 NA NA NA hsa-miR-616-5p HIF1A 0.150569904638223 0.402836556304524 -0.366176828296648 0.0111002186054683 MirTarget -0.124976106072862 0.00144238259369066 NA NA NA hsa-miR-660-5p HIF1A 0.989755850734071 5.69930767464937e-14 -0.366176828296648 0.0111002186054683 MirTarget -0.249870386379118 1.21860559731773e-06 NA NA NA hsa-miR-93-5p HIF1A 1.39518349670953 2.84167728726712e-25 -0.366176828296648 0.0111002186054683 MirTarget -0.173769064325932 0.000425501783480084 NA NA NA hsa-miR-155-5p HSD17B7 0.0108524225071784 0.95651331033505 0.53913301512498 0.00022130438994037 miRNAWalker2_validate -0.122748564015603 0.000633715589747904 NA NA NA hsa-miR-155-5p IL6R 0.0108524225071784 0.95651331033505 -0.197357669964791 0.382548993653367 MirTarget -0.277627367207754 4.05000284880467e-07 NA NA NA hsa-miR-616-5p ITK 0.150569904638223 0.402836556304524 -0.973916237026378 6.03308412083816e-05 mirMAP -0.195420985233781 0.00332703034341957 NA NA NA hsa-miR-139-5p JARID2 -2.11299531796557 8.16407076415038e-28 0.389563833569475 2.66930964150282e-05 miRanda -0.117957923371443 5.37316128023674e-08 NA NA NA hsa-miR-152-3p JARID2 -0.959123731390966 3.24700662487287e-10 0.389563833569475 2.66930964150282e-05 MirTarget -0.103357638574574 0.000388954384641091 NA NA NA hsa-miR-195-5p JARID2 -1.85907534356434 1.47434041676402e-22 0.389563833569475 2.66930964150282e-05 MirTarget;miRNATAP -0.156351527818008 1.41547841199883e-12 NA NA NA hsa-miR-22-3p JARID2 -0.628561621952407 1.33755558015523e-09 0.389563833569475 2.66930964150282e-05 miRNATAP -0.35698150181653 1.15371368306536e-17 NA NA NA hsa-miR-29a-3p JARID2 -0.856762511178136 4.65330336378459e-12 0.389563833569475 2.66930964150282e-05 MirTarget;miRNATAP -0.21140654437112 2.15614838088796e-09 NA NA NA hsa-miR-29b-3p JARID2 -0.348885528720517 0.0121441341291285 0.389563833569475 2.66930964150282e-05 MirTarget;miRNATAP -0.146033913140081 6.93268311946692e-06 NA NA NA hsa-miR-29c-3p JARID2 -1.4367517608807 1.61767774905781e-21 0.389563833569475 2.66930964150282e-05 MirTarget;miRNATAP -0.187450143768688 2.4296724546674e-11 NA NA NA hsa-miR-30a-5p JARID2 -0.626257932887855 0.000108198196973765 0.389563833569475 2.66930964150282e-05 MirTarget;miRNATAP -0.100514485951077 0.000308334807652441 NA NA NA hsa-miR-497-5p JARID2 -1.41371173021948 7.09278946477743e-17 0.389563833569475 2.66930964150282e-05 MirTarget;miRNATAP -0.196187672342973 4.46254962815538e-15 NA NA NA hsa-miR-155-5p JUP 0.0108524225071784 0.95651331033505 -0.0960901957303877 0.309160385000777 miRNAWalker2_validate -0.146841614798314 8.31952225321299e-11 NA NA NA hsa-miR-155-5p KANK2 0.0108524225071784 0.95651331033505 0.199487470591278 0.0838192746660065 miRNAWalker2_validate -0.121865867934348 1.41120859883442e-05 NA NA NA hsa-miR-155-5p KCND3 0.0108524225071784 0.95651331033505 -3.73766223806269 5.88031464564806e-19 mirMAP -0.235731665248148 0.0291783316210956 NA NA NA hsa-miR-140-3p KRAS 0.546012239205329 4.84578261098777e-11 -0.338081744192936 0.00043842779003105 MirTarget -0.247198429138234 9.22756583574077e-06 NA NA NA hsa-miR-16-1-3p KRAS 0.392360028038559 0.00112481918108198 -0.338081744192936 0.00043842779003105 mirMAP -0.114704330599848 0.00330327136149234 NA NA NA hsa-miR-193a-3p KRAS -0.117675551589896 0.309391958208578 -0.338081744192936 0.00043842779003105 MirTarget;miRanda;miRNATAP -0.128182356310374 0.00170700856743147 NA NA NA hsa-miR-193b-3p KRAS -0.166697207281748 0.272022543069482 -0.338081744192936 0.00043842779003105 miRNAWalker2_validate;MirTarget;miRNATAP -0.120510531869791 9.78248377856047e-05 25905463 Deregulation of the MiR 193b KRAS Axis Contributes to Impaired Cell Growth in Pancreatic Cancer; Mechanistically KRAS was verified as a direct effector of miR-193b through which the AKT and ERK pathways were modulated and cell growth of PDAC cells was suppressed; Taken together our findings indicate that miR-193b-mediated deregulation of the KRAS axis is involved in pancreatic carcinogenesis and suggest that miR-193b could be a potentially effective target for PDAC therapy tumorigenesis pancreatic cancer hsa-miR-30d-3p KRAS -0.120562286038759 0.329549534782125 -0.338081744192936 0.00043842779003105 MirTarget;miRNATAP -0.132565215112955 0.000512493362671086 NA NA NA hsa-miR-532-5p KRAS 1.02729546510601 9.93318913966636e-16 -0.338081744192936 0.00043842779003105 MirTarget;PITA;miRNATAP -0.137739612561571 0.000100604507963156 NA NA NA hsa-miR-155-5p KRCC1 0.0108524225071784 0.95651331033505 -0.503030842867513 6.14126801747858e-07 miRNAWalker2_validate -0.149492268934735 1.17430731692126e-09 NA NA NA hsa-miR-155-5p L2HGDH 0.0108524225071784 0.95651331033505 -0.858608570256839 3.35757853795555e-11 miRNAWalker2_validate -0.204354817094294 1.44026870171272e-10 NA NA NA hsa-miR-155-5p LCOR 0.0108524225071784 0.95651331033505 -0.828225234134718 0.000381975258357077 miRNATAP -0.118059398595587 0.040626352483353 NA NA NA hsa-miR-155-5p LEPROT 0.0108524225071784 0.95651331033505 -0.766289999290305 0.00143475208504872 mirMAP -0.149883757368657 0.0114778726635736 NA NA NA hsa-miR-155-5p LIMD1 0.0108524225071784 0.95651331033505 0.242601733850809 0.0190447425498849 mirMAP -0.105375288187533 2.91661389855801e-05 NA NA NA hsa-miR-155-5p LNX2 0.0108524225071784 0.95651331033505 -0.994497254361245 2.80455423894438e-17 miRNAWalker2_validate -0.107875744092876 0.00030912461094541 NA NA NA hsa-miR-155-5p LONP2 0.0108524225071784 0.95651331033505 -1.15752181481711 1.20062079208437e-15 miRNAWalker2_validate -0.169070320124553 3.50879861330723e-06 NA NA NA hsa-miR-106b-5p LRP1B 0.648901865047099 8.24870862047885e-09 -1.66988275957729 9.68113918882022e-05 MirTarget -0.396939529104581 0.0321445008990635 NA NA NA hsa-miR-107 LRP1B 0.241662461253461 0.0170788899505389 -1.66988275957729 9.68113918882022e-05 MirTarget;PITA;miRanda;miRNATAP -0.58947154465985 0.00488104681812695 NA NA NA hsa-miR-196b-5p LRP1B 0.984720966570163 0.00842452841223152 -1.66988275957729 9.68113918882022e-05 miRNATAP -0.122447224678144 0.0291504711170103 NA NA NA hsa-miR-200b-3p LRP1B -1.29335788099229 0.000268623234305059 -1.66988275957729 9.68113918882022e-05 MirTarget;TargetScan -0.144543468981676 0.0140409074719293 NA NA NA hsa-miR-335-3p LRP1B -0.275199247483111 0.106629165248783 -1.66988275957729 9.68113918882022e-05 MirTarget;mirMAP -0.254164757009048 0.0401191953696966 NA NA NA hsa-miR-429 LRP1B -1.40262535827285 6.93982219171912e-05 -1.66988275957729 9.68113918882022e-05 MirTarget;PITA;miRanda;miRNATAP -0.214578801279887 0.000326251251873705 NA NA NA hsa-miR-454-3p LRP1B 0.668749059573955 2.42670710515113e-06 -1.66988275957729 9.68113918882022e-05 miRNATAP -0.460082982433523 0.00174467518861991 NA NA NA hsa-miR-455-5p LRP1B -0.270546034117157 0.0581320703577731 -1.66988275957729 9.68113918882022e-05 miRanda -0.566348337580109 0.000119186814695954 NA NA NA hsa-miR-155-5p MBLAC2 0.0108524225071784 0.95651331033505 -0.651946233751667 4.55219397233215e-07 miRNAWalker2_validate -0.208442215729836 3.20921974208656e-11 NA NA NA hsa-miR-155-5p METTL7A 0.0108524225071784 0.95651331033505 -1.15038870624553 1.17460294487533e-12 miRNAWalker2_validate -0.291575630895679 2.10801038889062e-13 NA NA NA hsa-miR-155-5p MFAP3L 0.0108524225071784 0.95651331033505 -2.99511248620354 4.97173912475439e-19 mirMAP -0.206174009891065 0.0170026189004632 NA NA NA hsa-miR-155-5p MGST2 0.0108524225071784 0.95651331033505 -0.570019802200203 1.11811942571792e-05 miRNAWalker2_validate -0.144441960104786 5.79089633146299e-06 NA NA NA hsa-miR-155-5p MKLN1 0.0108524225071784 0.95651331033505 -0.425749106325366 6.88700394811851e-08 mirMAP -0.117291335862729 1.06299489635983e-09 NA NA NA hsa-miR-155-5p MORC3 0.0108524225071784 0.95651331033505 -0.493622872657661 7.75189399922391e-06 miRNAWalker2_validate;MirTarget -0.126872020563458 2.76864949872738e-06 NA NA NA hsa-miR-155-5p MPP5 0.0108524225071784 0.95651331033505 -0.288077654324143 0.00156212311296768 miRNAWalker2_validate;MirTarget -0.110442087685103 6.02471832816348e-07 NA NA NA hsa-miR-155-5p MRPS27 0.0108524225071784 0.95651331033505 0.0788360224665174 0.300167697387518 miRNAWalker2_validate -0.100078444191655 4.52354617434004e-08 NA NA NA hsa-miR-155-5p MRS2 0.0108524225071784 0.95651331033505 0.37675345499823 4.28238645214564e-06 miRNAWalker2_validate -0.103195332593599 2.48935793593545e-07 NA NA NA hsa-miR-155-5p MUT 0.0108524225071784 0.95651331033505 -1.593866234 8.76749160812344e-25 miRNAWalker2_validate -0.231353108738906 5.88172290045159e-09 23715647 The regulation of Mut L homologue 1 MLH1 expression by microRNA miR-155 and its prognostic significance in pancreatic cancer PC remain to be elucidated pancreatic cancer hsa-miR-155-5p NDFIP1 0.0108524225071784 0.95651331033505 -0.228407565966697 0.00532073775853203 MirTarget;miRNATAP -0.110044777872936 2.71111188289469e-08 NA NA NA hsa-miR-155-5p NFIA 0.0108524225071784 0.95651331033505 -0.924685216157224 2.60745966247054e-13 miRNATAP -0.214818882827262 5.52992527016456e-12 NA NA NA hsa-miR-155-5p NFIB 0.0108524225071784 0.95651331033505 -0.473125743246742 0.000230272053316789 miRNATAP -0.134017485608918 2.06309503457326e-05 NA NA NA hsa-miR-155-5p NGEF 0.0108524225071784 0.95651331033505 0.0629700752548423 0.706203839940708 miRNATAP -0.220380957756073 4.75263664977831e-08 NA NA NA hsa-miR-155-5p NNT 0.0108524225071784 0.95651331033505 -1.00636428911703 1.46289096561224e-10 mirMAP -0.237163537320628 8.76069588004836e-10 NA NA NA hsa-miR-155-5p NR3C1 0.0108524225071784 0.95651331033505 -0.4313634018742 3.79689238088369e-06 miRNAWalker2_validate -0.130772411345416 8.68085514995749e-09 NA NA NA hsa-miR-155-5p OXNAD1 0.0108524225071784 0.95651331033505 -0.650767757246929 1.84044569244425e-10 miRNAWalker2_validate -0.105683501759478 3.17506191203001e-05 NA NA NA hsa-miR-155-5p PACSIN3 0.0108524225071784 0.95651331033505 -0.55582309649623 0.00343440982314035 miRNAWalker2_validate -0.234449259815292 4.00987822199774e-07 NA NA NA hsa-miR-155-5p PANK1 0.0108524225071784 0.95651331033505 -1.78611804711646 1.3683840906107e-26 miRNATAP -0.280014001134565 6.64870583472353e-11 NA NA NA hsa-miR-155-5p PCCB 0.0108524225071784 0.95651331033505 -0.680050604129235 3.63211805735208e-09 miRNAWalker2_validate -0.122362278416459 1.8599754516626e-05 NA NA NA hsa-miR-155-5p PCYOX1 0.0108524225071784 0.95651331033505 -0.710952952600329 8.62737880229856e-10 miRNAWalker2_validate -0.228179869191462 3.56343285224195e-16 NA NA NA hsa-miR-155-5p PEBP1 0.0108524225071784 0.95651331033505 -0.878608443206359 1.29047964027122e-09 miRNAWalker2_validate -0.232542421728628 5.4459080626597e-11 NA NA NA hsa-let-7b-3p PLAG1 -1.21979213547786 5.84575581584603e-17 1.04276161449411 0.000370375517337123 MirTarget;miRNATAP -0.449720202142503 1.78058503771751e-06 NA NA NA hsa-miR-101-3p PLAG1 -1.48176407980989 3.98950707385704e-31 1.04276161449411 0.000370375517337123 miRNAWalker2_validate -0.492857965353428 2.01754717477225e-06 NA NA NA hsa-miR-125b-2-3p PLAG1 -1.6609436107315 5.71534047969855e-18 1.04276161449411 0.000370375517337123 mirMAP -0.167139004994353 0.0199712904112656 NA NA NA hsa-miR-139-5p PLAG1 -2.11299531796557 8.16407076415038e-28 1.04276161449411 0.000370375517337123 PITA;mirMAP -0.195722644734342 0.00482284525861395 NA NA NA hsa-miR-144-3p PLAG1 -2.97536914478815 6.00546047309683e-28 1.04276161449411 0.000370375517337123 miRNAWalker2_validate;miRTarBase;miRNATAP -0.114495060986931 0.020513666804187 NA NA NA hsa-miR-195-3p PLAG1 -1.09375690196245 4.70092324819807e-09 1.04276161449411 0.000370375517337123 mirMAP;miRNATAP -0.350921049530229 3.81213577382904e-06 NA NA NA hsa-miR-195-5p PLAG1 -1.85907534356434 1.47434041676402e-22 1.04276161449411 0.000370375517337123 MirTarget;miRNATAP -0.48949879528453 2.35350176651651e-12 NA NA NA hsa-miR-199a-3p PLAG1 -2.3279328685682 1.04468066198593e-17 1.04276161449411 0.000370375517337123 PITA;miRNATAP -0.120678920255867 0.0173348175568722 NA NA NA hsa-miR-199b-3p PLAG1 -2.33226605401203 9.51887435273314e-18 1.04276161449411 0.000370375517337123 PITA;miRNATAP -0.12127159079604 0.0167100121542385 NA NA NA hsa-miR-22-5p PLAG1 -0.630365901263172 3.32415348030414e-05 1.04276161449411 0.000370375517337123 miRNATAP -0.188679541192482 0.0452062193024568 NA NA NA hsa-miR-29a-3p PLAG1 -0.856762511178136 4.65330336378459e-12 1.04276161449411 0.000370375517337123 miRNATAP -0.251359789383966 0.0270578589002194 NA NA NA hsa-miR-29c-3p PLAG1 -1.4367517608807 1.61767774905781e-21 1.04276161449411 0.000370375517337123 miRNAWalker2_validate;miRNATAP -0.255153241770635 0.00489378329751096 NA NA NA hsa-miR-30a-3p PLAG1 -1.52720594401486 1.3830066075708e-17 1.04276161449411 0.000370375517337123 mirMAP -0.379846709531326 6.49398893736623e-07 NA NA NA hsa-miR-30a-5p PLAG1 -0.626257932887855 0.000108198196973765 1.04276161449411 0.000370375517337123 mirMAP;miRNATAP -0.335370085624785 0.000137505406029602 NA NA NA hsa-miR-30e-3p PLAG1 -1.20845647373031 3.10263633528203e-25 1.04276161449411 0.000370375517337123 mirMAP -0.386487453095962 0.000909279250387651 NA NA NA hsa-miR-3607-3p PLAG1 -2.15518588554493 1.03390728226728e-23 1.04276161449411 0.000370375517337123 miRNATAP -0.131059636408049 0.0383771647382902 NA NA NA hsa-miR-3653-3p PLAG1 -1.77536656608462 3.05384496241509e-24 1.04276161449411 0.000370375517337123 MirTarget -0.20744439940563 0.00766823852708663 NA NA NA hsa-miR-424-5p PLAG1 -2.62653257498508 2.38997974737991e-50 1.04276161449411 0.000370375517337123 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.177819925899293 0.0136798178293059 NA NA NA hsa-miR-497-5p PLAG1 -1.41371173021948 7.09278946477743e-17 1.04276161449411 0.000370375517337123 MirTarget;miRNATAP -0.476261199541901 3.02525882273326e-09 NA NA NA hsa-miR-155-5p PLEKHA5 0.0108524225071784 0.95651331033505 0.149369155046236 0.208207426046055 miRNAWalker2_validate -0.117585252472261 4.69861207524474e-05 NA NA NA hsa-miR-155-5p PLS1 0.0108524225071784 0.95651331033505 -0.343978850494421 0.037888216094636 miRNAWalker2_validate -0.173451845017397 1.76293430598175e-05 NA NA NA hsa-miR-155-5p PNPLA4 0.0108524225071784 0.95651331033505 -0.73077585407305 8.93024606858533e-11 miRNAWalker2_validate -0.179495558170541 8.78301844770476e-11 NA NA NA hsa-miR-155-5p POLR1B 0.0108524225071784 0.95651331033505 -0.273279410335916 0.000945601166132151 miRNAWalker2_validate -0.107382608357051 8.2706411846296e-08 NA NA NA hsa-miR-155-5p PPARA 0.0108524225071784 0.95651331033505 -0.607171871846345 3.30592576448713e-05 mirMAP -0.222812834390595 3.39989479069212e-10 NA NA NA hsa-miR-155-5p PPL 0.0108524225071784 0.95651331033505 -1.28776765005881 1.67755407466823e-08 miRNAWalker2_validate -0.325084480642158 6.84985100984824e-09 NA NA NA hsa-miR-155-5p PPM1L 0.0108524225071784 0.95651331033505 -0.358173274286561 0.0774099414261059 mirMAP -0.121047215245888 0.0151083917970025 NA NA NA hsa-miR-155-5p PRKAR1A 0.0108524225071784 0.95651331033505 -0.221339462064076 0.0226218115406206 miRNAWalker2_validate -0.114318738366975 1.21359964338562e-06 NA NA NA hsa-miR-155-5p PRKAR2A 0.0108524225071784 0.95651331033505 -0.445956894636509 0.039701655854281 miRNAWalker2_validate -0.109943534691235 0.039319351819679 NA NA NA hsa-miR-155-5p PROX1 0.0108524225071784 0.95651331033505 -1.50692887128896 6.55353144337011e-08 miRNATAP -0.275536362348153 6.82662995479706e-05 NA NA NA hsa-miR-155-5p PTMS 0.0108524225071784 0.95651331033505 -0.992988085020651 1.37259745462155e-11 miRNAWalker2_validate -0.117888231808866 0.00138795215220809 NA NA NA hsa-miR-155-5p PTPRG 0.0108524225071784 0.95651331033505 0.490912263823608 0.00324856263309075 mirMAP -0.115932923296545 0.00472552709378622 NA NA NA hsa-miR-155-5p RAD23B 0.0108524225071784 0.95651331033505 -0.349483835523183 2.52871873211643e-06 miRNAWalker2_validate -0.113510484759349 2.70997112008267e-10 NA NA NA hsa-miR-155-5p RAPGEF2 0.0108524225071784 0.95651331033505 -0.707388543717723 1.66316838166028e-08 miRNAWalker2_validate;MirTarget -0.127471207566977 4.07796299788839e-05 NA NA NA hsa-miR-155-5p RAPGEF4 0.0108524225071784 0.95651331033505 -1.07075647385906 1.41124137066171e-09 miRNATAP -0.182384216030019 3.40319317364143e-05 NA NA NA hsa-miR-155-5p REPS2 0.0108524225071784 0.95651331033505 -1.10574349357584 1.56638093233755e-10 MirTarget;miRNATAP -0.198373627430735 3.95545898043281e-06 NA NA NA hsa-miR-155-5p RETSAT 0.0108524225071784 0.95651331033505 -0.791576872042796 1.56281003909036e-08 miRNAWalker2_validate -0.237476919807963 3.16689044194734e-12 NA NA NA hsa-miR-155-5p RING1 0.0108524225071784 0.95651331033505 0.388258031884674 1.82939806340374e-05 miRNAWalker2_validate -0.155176507675941 1.07262698130897e-12 NA NA NA hsa-miR-155-5p RORA 0.0108524225071784 0.95651331033505 -1.18591701647076 1.08163415927424e-11 MirTarget;mirMAP;miRNATAP -0.24868760836742 8.9611945229711e-09 NA NA NA hsa-miR-181c-5p RPS6KA3 -0.00639394152050299 0.969127212255928 -0.0721830047612428 0.620235959053163 MirTarget;mirMAP;miRNATAP -0.132982978659169 0.00196775794236537 NA NA NA hsa-miR-497-5p RPS6KA3 -1.41371173021948 7.09278946477743e-17 -0.0721830047612428 0.620235959053163 MirTarget;miRNATAP -0.106167734324023 0.00837538561255109 NA NA NA hsa-miR-155-5p RREB1 0.0108524225071784 0.95651331033505 -0.26573997859693 0.0940609822911551 miRNAWalker2_validate;miRNATAP -0.192875648147577 5.4870011894214e-07 NA NA NA hsa-miR-155-5p RSPO2 0.0108524225071784 0.95651331033505 -1.47503442551075 0.000466618278395286 miRNATAP -0.462257092290775 7.64386305486594e-06 NA NA NA hsa-miR-155-5p SALL1 0.0108524225071784 0.95651331033505 -1.08990282256837 2.30542602372023e-08 miRNATAP -0.328586949823167 4.67743297511162e-12 NA NA NA hsa-miR-155-5p SAP30L 0.0108524225071784 0.95651331033505 0.39637668016416 2.08535958030862e-06 miRNAWalker2_validate -0.132108167446333 6.40929092899125e-11 NA NA NA hsa-miR-155-5p SAR1B 0.0108524225071784 0.95651331033505 -0.602691569549908 4.60715859176311e-06 MirTarget -0.124623670438797 0.000122301706534568 NA NA NA hsa-miR-17-5p SATB1 0.698861147045461 2.43854106455398e-05 -1.66235785428604 6.97431443036821e-14 TargetScan -0.276458036663075 3.27685892254495e-05 NA NA NA hsa-miR-18a-5p SATB1 0.918028187958706 1.90229510425322e-05 -1.66235785428604 6.97431443036821e-14 miRNATAP -0.227368128542947 8.77139882744632e-06 NA NA NA hsa-miR-194-5p SATB1 -0.292530160992458 0.0996141384876663 -1.66235785428604 6.97431443036821e-14 miRNATAP -0.134580750428564 0.0327838314495217 NA NA NA hsa-miR-19a-3p SATB1 1.01712596153672 2.57753201450625e-07 -1.66235785428604 6.97431443036821e-14 miRNATAP -0.173438620818127 0.00185104794577535 NA NA NA hsa-miR-19b-3p SATB1 0.601279551368824 0.00016685097085251 -1.66235785428604 6.97431443036821e-14 miRNATAP -0.172150078172972 0.0134448122903903 NA NA NA hsa-miR-21-5p SATB1 1.51084295924322 1.54551622173259e-34 -1.66235785428604 6.97431443036821e-14 MirTarget;miRNATAP -0.340471853554043 4.20923938471208e-05 27107063 SATB1 is Down regulated in Clear Cell Renal Cell Carcinoma and Correlates with miR 21 5p Overexpression and Poor Prognosis; This study aimed to determine the expression levels of SATB1 as well as miR-21-5p -the post-transcriptional repressor of SATB1 expression- in clear cell renal cell carcinoma ccRCC and to investigate their association with the progression of ccRCC; Immunohistochemistry and quantitative polymerase chain reaction were used to assess the expression of SATB1 protein and mRNA as well as miR-21-5p in tumor and matched normal kidney tissues collected from 56 ccRCC patients; SATB1 mRNA level was down-regulated in ccRCC tissue and inversely correlated with the content of miR-21-5p; Down-regulation of SATB1 mRNA and up-regulation of miR-21-5p were associated with shorter patient survival; Decreased expression of SATB1 in ccRCC may result from over-expressed miR-21-5p worse prognosis;progression;poor survival kidney renal cell cancer hsa-miR-30d-5p SATB1 0.718283816348023 2.47422074061352e-08 -1.66235785428604 6.97431443036821e-14 miRNATAP -0.475887255578985 1.72839023230587e-08 NA NA NA hsa-miR-32-3p SATB1 0.219109440121582 0.207217051619543 -1.66235785428604 6.97431443036821e-14 mirMAP -0.258240420499369 9.640300569718e-05 NA NA NA hsa-miR-324-5p SATB1 0.372933276649782 0.00592280066108904 -1.66235785428604 6.97431443036821e-14 miRanda -0.386591129321857 2.28303454621177e-06 NA NA NA hsa-miR-34a-5p SATB1 1.03694231790865 5.74864019540594e-14 -1.66235785428604 6.97431443036821e-14 MirTarget;miRNATAP -0.374029558942121 1.60542096572095e-06 NA NA NA hsa-miR-362-3p SATB1 0.814007335895913 2.00108618836568e-09 -1.66235785428604 6.97431443036821e-14 miRanda -0.283455811406857 0.00044927736730718 NA NA NA hsa-miR-362-5p SATB1 0.717921690799312 1.68392734504524e-05 -1.66235785428604 6.97431443036821e-14 PITA;miRNATAP -0.233625354160063 0.00041894236888186 NA NA NA hsa-miR-500a-3p SATB1 1.18913245435489 1.59516890341346e-16 -1.66235785428604 6.97431443036821e-14 MirTarget;miRNATAP -0.335342375712659 6.20889246562285e-06 NA NA NA hsa-miR-501-3p SATB1 0.999540908940094 2.77358485581974e-11 -1.66235785428604 6.97431443036821e-14 miRNATAP -0.351384234223711 1.08594861994127e-06 NA NA NA hsa-miR-501-5p SATB1 1.15231083477882 2.98906150004088e-10 -1.66235785428604 6.97431443036821e-14 miRNATAP -0.262398322929622 1.00757502966877e-05 NA NA NA hsa-miR-589-3p SATB1 1.16846704028095 5.88525574424201e-11 -1.66235785428604 6.97431443036821e-14 MirTarget -0.180832679926284 0.0038036138829223 NA NA NA hsa-miR-664a-3p SATB1 0.485807855553031 0.000732553249798598 -1.66235785428604 6.97431443036821e-14 mirMAP -0.160146681271073 0.0391431254095977 NA NA NA hsa-miR-155-5p SEC14L5 0.0108524225071784 0.95651331033505 0.311980940356044 0.259327528499545 miRNATAP -0.265100003297076 8.59334849100979e-05 NA NA NA hsa-miR-155-5p SERPINA10 0.0108524225071784 0.95651331033505 -1.56538827041841 1.7799729849669e-09 MirTarget -0.158722325680707 0.0149056959322059 NA NA NA hsa-miR-155-5p SGPL1 0.0108524225071784 0.95651331033505 -0.0778567650183533 0.386893488491354 miRNAWalker2_validate -0.106848281749873 8.98568678249193e-07 NA NA NA hsa-miR-155-5p SH3BP4 0.0108524225071784 0.95651331033505 -0.172046131729646 0.234489669983901 miRNAWalker2_validate -0.271217333051531 2.67274451556912e-15 NA NA NA hsa-miR-155-5p SIM2 0.0108524225071784 0.95651331033505 0.05707677985163 0.749312535234526 miRNATAP -0.174142036244719 6.29170402833948e-05 NA NA NA hsa-miR-155-5p SLC13A3 0.0108524225071784 0.95651331033505 -1.65071185064405 0.00114310814566582 mirMAP -0.289041405693231 0.0211124474603723 NA NA NA hsa-miR-155-5p SLC1A2 0.0108524225071784 0.95651331033505 -2.05184743338733 5.07102901300161e-06 mirMAP -0.584693466041779 1.138723834292e-07 NA NA NA hsa-miR-155-5p SLC20A2 0.0108524225071784 0.95651331033505 -0.68218249424573 3.91735961922429e-06 miRNATAP -0.210298622855543 5.47613243728021e-09 NA NA NA hsa-miR-155-5p SLC27A2 0.0108524225071784 0.95651331033505 -2.03904770056737 1.1897256503993e-12 miRNAWalker2_validate -0.203888375735192 0.00487378136190532 NA NA NA hsa-miR-155-5p SLC30A1 0.0108524225071784 0.95651331033505 -1.21292412377968 4.55064472411421e-13 miRNAWalker2_validate -0.171959441071313 4.39475768585678e-05 NA NA NA hsa-miR-155-5p SLC9A3R2 0.0108524225071784 0.95651331033505 -0.895960756907251 1.34323434090968e-08 miRNAWalker2_validate -0.121597116788814 0.00197882682943423 NA NA NA hsa-miR-155-5p SLCO1A2 0.0108524225071784 0.95651331033505 -1.53455538662681 4.79106917340698e-05 mirMAP -0.187944978466951 0.044688622312514 NA NA NA hsa-miR-155-5p SMAD3 0.0108524225071784 0.95651331033505 0.313849246286883 0.00280528337161062 miRNAWalker2_validate -0.143616291871971 1.61818308217997e-08 27626488 Here we demonstrated that TGF-β1 elevated the expression of miR-155 in colorectal cancer cells through SMAD3 and SMAD4 colorectal cancer hsa-miR-155-5p SMARCD2 0.0108524225071784 0.95651331033505 0.108275551344589 0.20709456021372 miRNAWalker2_validate -0.109655124453105 1.17101620841676e-07 NA NA NA hsa-miR-155-5p SNED1 0.0108524225071784 0.95651331033505 -0.697753140844763 1.06949754459612e-05 mirMAP -0.185295498437795 1.89473866855404e-06 NA NA NA hsa-miR-122-5p SOCS1 -1.23907441373955 4.42181244888642e-06 -0.39709090094722 0.0775490855454473 miRNAWalker2_validate -0.138451063557538 0.000543541554177701 NA NA NA hsa-miR-155-5p SOCS6 0.0108524225071784 0.95651331033505 -1.07676840516879 9.71590997834803e-26 miRNATAP -0.103950845649749 9.47830088771288e-05 26692956 Further we identified SOCS6 as a new direct target of miR-155; Sustained overexpression of miR-155 resulted in repression of SOCS6 protein and mRNA levels and knockdown of miR-155 increased SOCS6 expression breast cancer hsa-miR-155-5p SORL1 0.0108524225071784 0.95651331033505 -1.76063037333749 3.20297520312196e-18 miRNATAP -0.201045260217915 9.67076912378894e-05 NA NA NA hsa-miR-155-5p TAPT1 0.0108524225071784 0.95651331033505 -1.13334263866931 3.16520734266326e-25 MirTarget -0.207597556281217 5.65843686090102e-14 NA NA NA hsa-miR-155-5p TBCA 0.0108524225071784 0.95651331033505 0.154365978790601 0.12433894469935 miRNAWalker2_validate -0.10497315761653 1.70063808118497e-05 NA NA NA hsa-miR-155-5p TJP1 0.0108524225071784 0.95651331033505 0.0011791046353169 0.990690010235753 miRNAWalker2_validate -0.116102532819546 2.07063058961853e-06 NA NA NA hsa-miR-155-5p TMBIM6 0.0108524225071784 0.95651331033505 -0.8739716428039 2.36157745837239e-20 miRNAWalker2_validate -0.143351054819095 1.89820924595827e-09 NA NA NA hsa-miR-155-5p TOMM20 0.0108524225071784 0.95651331033505 0.593385998783792 6.69647218460373e-11 miRNAWalker2_validate;MirTarget;miRNATAP -0.127600303868971 1.26459186573063e-08 NA NA NA hsa-miR-32-3p TP53INP1 0.219109440121582 0.207217051619543 -0.285197501864762 0.0881794554422379 mirMAP -0.258632758699847 6.80332018088533e-08 NA NA NA hsa-miR-374a-5p TP53INP1 0.016390363747302 0.869784217438621 -0.285197501864762 0.0881794554422379 mirMAP -0.207906635794149 0.0118042563338924 NA NA NA hsa-miR-374b-3p TP53INP1 -0.137420230218985 0.305318192448799 -0.285197501864762 0.0881794554422379 mirMAP -0.131332796226761 0.0321855078089302 NA NA NA hsa-miR-374b-5p TP53INP1 -0.307538028546424 0.0030079617545972 -0.285197501864762 0.0881794554422379 mirMAP -0.168067474644992 0.0338995911875085 NA NA NA hsa-miR-590-3p TP53INP1 -0.473167498047808 1.76652934637227e-05 -0.285197501864762 0.0881794554422379 PITA;miRanda;mirMAP -0.161320213992633 0.029148024062306 NA NA NA hsa-miR-616-5p TP53INP1 0.150569904638223 0.402836556304524 -0.285197501864762 0.0881794554422379 mirMAP -0.13697060015773 0.00258505393555118 NA NA NA hsa-miR-93-5p TP53INP1 1.39518349670953 2.84167728726712e-25 -0.285197501864762 0.0881794554422379 miRNAWalker2_validate;miRTarBase -0.114035709880115 0.0469582022775501 NA NA NA hsa-miR-155-5p TRIM2 0.0108524225071784 0.95651331033505 -0.669569001903942 0.000204730952595103 miRNATAP -0.110764190040863 0.0129215789588815 NA NA NA hsa-miR-155-5p TRIM23 0.0108524225071784 0.95651331033505 -0.298910242960821 0.000941811896082851 MirTarget -0.116730098790298 1.01595723880271e-07 NA NA NA hsa-miR-155-5p TRPM8 0.0108524225071784 0.95651331033505 -2.59510990384796 6.63944031656008e-12 MirTarget -0.223152745349516 0.0193060819427182 NA NA NA hsa-miR-155-5p TTC37 0.0108524225071784 0.95651331033505 -0.0480493869936982 0.795496846496803 miRNAWalker2_validate -0.125907742415479 0.00554505412288674 NA NA NA hsa-miR-155-5p TYSND1 0.0108524225071784 0.95651331033505 0.507266973985128 1.57055994947472e-05 miRNAWalker2_validate -0.111793189728874 0.000110273321729691 NA NA NA hsa-miR-155-5p UAP1 0.0108524225071784 0.95651331033505 -0.605467247884315 5.25813633839014e-07 miRNAWalker2_validate -0.118225776757768 7.31649890787793e-05 NA NA NA hsa-miR-155-5p UBE2H 0.0108524225071784 0.95651331033505 -0.0940541549702418 0.361946835120909 miRNAWalker2_validate -0.11411206988221 5.07658480000981e-06 NA NA NA hsa-miR-155-5p UBR3 0.0108524225071784 0.95651331033505 -0.651263693121249 4.19615459779866e-12 miRNATAP -0.135548870118593 5.42671286374003e-09 NA NA NA hsa-miR-155-5p UHMK1 0.0108524225071784 0.95651331033505 -0.803204254827771 0.00347508080027661 mirMAP -0.157298066625835 0.0202997254237555 NA NA NA hsa-miR-155-5p VKORC1L1 0.0108524225071784 0.95651331033505 -0.437057501700886 5.88971250408357e-09 mirMAP -0.117686653859088 1.24306454962116e-10 NA NA NA hsa-miR-155-5p VPS36 0.0108524225071784 0.95651331033505 -0.567458160061146 1.90597492149183e-08 miRNAWalker2_validate -0.101676449145032 4.74571848435479e-05 NA NA NA hsa-miR-155-5p WNK3 0.0108524225071784 0.95651331033505 -0.836532944570787 0.00785592148273515 miRNATAP -0.3220024773483 2.88121409202313e-05 NA NA NA hsa-miR-155-5p XPC 0.0108524225071784 0.95651331033505 -0.260289561198818 0.00244623681546274 miRNAWalker2_validate -0.162519663776007 1.53720728473938e-15 NA NA NA hsa-miR-155-5p ZBTB10 0.0108524225071784 0.95651331033505 -1.01864761075705 2.61637300384558e-12 mirMAP -0.111614894708528 0.00231614909423942 NA NA NA hsa-miR-155-5p ZFAND5 0.0108524225071784 0.95651331033505 -0.89687020061194 5.59442964172277e-08 mirMAP -0.174795377700524 1.90296655036467e-05 NA NA NA hsa-miR-155-5p ZNF254 0.0108524225071784 0.95651331033505 -0.523499667824194 0.00058213648009003 miRNAWalker2_validate -0.108767585994494 0.00371958025159425 NA NA NA hsa-miR-155-5p ZNRF3 0.0108524225071784 0.95651331033505 -0.167866805092005 0.391803552621188 miRNATAP -0.283320291523574 1.97748872502476e-09 NA NA NA