miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-21-5p ABAT 1.0504925175311 2.58081295984106e-11 -0.356262869644786 1.80045365680947e-05 MirTarget -0.256032269654986 4.14383969002155e-39 NA NA NA hsa-miR-21-3p ABI2 1.3484283943822 2.0036022227401e-17 -0.176174326299864 0.00158053725448693 MirTarget -0.102512198162884 1.12333342648505e-27 NA NA NA hsa-miR-21-5p ACBD5 1.0504925175311 2.58081295984106e-11 -0.311230529317669 9.09528601484802e-08 miRNAWalker2_validate;miRNATAP -0.115153808011155 5.75049986020304e-17 NA NA NA hsa-miR-21-5p ACVR2A 1.0504925175311 2.58081295984106e-11 -0.119968776031365 0.00731502240961848 miRNATAP -0.109881536824673 6.09617376179327e-21 NA NA NA hsa-miR-21-5p ADCY2 1.0504925175311 2.58081295984106e-11 -0.550745338386567 2.16518089273288e-07 MirTarget -0.183376251568948 1.65701643647886e-09 NA NA NA hsa-miR-21-3p AFF2 1.3484283943822 2.0036022227401e-17 -0.9491060103971 2.02262807747919e-09 mirMAP -0.439327280555023 1.77208152936731e-26 NA NA NA hsa-miR-21-3p AKAP11 1.3484283943822 2.0036022227401e-17 -0.320762802867723 1.46278439057032e-06 MirTarget -0.116826135264021 1.17436872518496e-15 NA NA NA hsa-miR-21-5p AKAP6 1.0504925175311 2.58081295984106e-11 -0.539490475083872 1.98751941618642e-10 MirTarget -0.176877005159329 5.24236268560804e-14 NA NA NA hsa-miR-21-3p ALCAM 1.3484283943822 2.0036022227401e-17 -0.275007884293424 0.000504783565310168 MirTarget -0.122154790482559 3.09716694890802e-12 27153478 Enhanced expression of CD44 CD166 and miR-21 with miR-215 was found in the specimens obtained at follow-up despite alleviation of mucosal lesions colorectal cancer hsa-miR-21-3p AMOT 1.3484283943822 2.0036022227401e-17 -0.503852515305114 6.05062076962384e-07 mirMAP -0.144411914667463 1.99073986874117e-08 NA NA NA hsa-miR-21-5p ANKRD46 1.0504925175311 2.58081295984106e-11 -0.329751910559951 1.29000734601328e-08 miRNAWalker2_validate;miRTarBase -0.208615410664561 2.34532803031741e-52 21219636 Knockdown of miR-21 significantly increased the expression of ANKRD46 at both mRNA and protein levels; ANKRD46 is newly identified as a direct target of miR-21 in BC breast cancer hsa-miR-21-5p ANKS1B 1.0504925175311 2.58081295984106e-11 -0.427680560625848 0.000104430220578689 MirTarget -0.257549219387054 1.51599957197213e-14 NA NA NA hsa-miR-21-5p ANO3 1.0504925175311 2.58081295984106e-11 -0.67859762125394 6.15174649955716e-05 mirMAP -0.402323228920115 9.46264058167918e-15 NA NA NA hsa-miR-21-5p ARHGAP32 1.0504925175311 2.58081295984106e-11 -0.393844459751915 2.19156147069685e-08 MirTarget -0.175050973239613 4.32610196225739e-22 NA NA NA hsa-miR-21-3p ARHGAP36 1.3484283943822 2.0036022227401e-17 -0.924172030902999 8.77586317983144e-08 MirTarget -0.280847731903968 2.25008706027103e-09 NA NA NA hsa-miR-21-3p ARMC5 1.3484283943822 2.0036022227401e-17 -0.0922688523241524 0.0843984966396231 mirMAP -0.105509849283954 7.4366781240318e-18 NA NA NA hsa-miR-21-3p ASB1 1.3484283943822 2.0036022227401e-17 -0.22273099907543 0.000133767589447156 MirTarget -0.123956981001632 2.04015833124519e-22 NA NA NA hsa-miR-21-5p ASF1A 1.0504925175311 2.58081295984106e-11 -0.165400676824631 0.00103470388813894 miRNATAP -0.124930917772428 5.90745600455165e-23 NA NA NA hsa-miR-21-5p ASRGL1 1.0504925175311 2.58081295984106e-11 -0.323589677024819 1.7174035660774e-07 miRNAWalker2_validate -0.198575585377101 3.42215748803705e-35 NA NA NA hsa-miR-21-5p ATP2B2 1.0504925175311 2.58081295984106e-11 -0.463711598489561 1.29638284873031e-05 mirMAP -0.322630738984878 2.41186823923519e-26 NA NA NA hsa-miR-21-3p ATRNL1 1.3484283943822 2.0036022227401e-17 -0.536903703782661 2.49247942618736e-06 MirTarget -0.224119464683312 4.67397841972344e-14 NA NA NA hsa-miR-21-5p ATRNL1 1.0504925175311 2.58081295984106e-11 -0.536903703782661 2.49247942618736e-06 MirTarget -0.259897606365245 2.69628029636976e-14 NA NA NA hsa-miR-21-5p ATRX 1.0504925175311 2.58081295984106e-11 0.00082443450307057 0.992488330570116 miRNAWalker2_validate -0.105212144122095 4.65569044345593e-05 NA NA NA hsa-miR-21-5p AUTS2 1.0504925175311 2.58081295984106e-11 -0.0630211320780845 0.29094099874943 miRNAWalker2_validate -0.119950363359054 7.86746208258862e-15 NA NA NA hsa-miR-21-5p B3GAT2 1.0504925175311 2.58081295984106e-11 -0.629701032075904 4.35598146802671e-06 MirTarget -0.403262159515075 4.08723658126283e-23 NA NA NA hsa-miR-21-3p B4GALT6 1.3484283943822 2.0036022227401e-17 -0.315354361626438 0.000304481135366713 MirTarget -0.107001556877214 3.71326569771398e-06 NA NA NA hsa-miR-21-5p BASP1 1.0504925175311 2.58081295984106e-11 -0.486211739382857 6.48040257284722e-07 miRNAWalker2_validate;miRTarBase -0.27569976304215 5.12523309872382e-24 NA NA NA hsa-miR-21-5p BEST3 1.0504925175311 2.58081295984106e-11 -0.159515530817997 0.286587263517032 MirTarget -0.197171537554036 1.54585421857733e-05 NA NA NA hsa-miR-21-5p BTBD9 1.0504925175311 2.58081295984106e-11 -0.201360130015768 0.000196326271741367 mirMAP -0.101455386436615 6.59791250805965e-13 NA NA NA hsa-miR-21-5p C11orf87 1.0504925175311 2.58081295984106e-11 -0.498008175574544 0.0287178375994813 mirMAP;miRNATAP -0.406929861038243 7.59691258248238e-09 NA NA NA hsa-miR-21-5p C16orf52 1.0504925175311 2.58081295984106e-11 -0.202496300136654 8.79462215847826e-06 miRNATAP -0.111150964312774 2.84405708483918e-21 NA NA NA hsa-miR-21-5p C8orf44 1.0504925175311 2.58081295984106e-11 -0.199818056780241 7.18897842887721e-07 mirMAP -0.106937637146507 1.14198891687918e-18 NA NA NA hsa-miR-21-5p CACNA1E 1.0504925175311 2.58081295984106e-11 -0.569847771875012 9.69601679094844e-05 mirMAP -0.451889095936332 3.2593879420763e-25 NA NA NA hsa-miR-21-3p CACNA2D1 1.3484283943822 2.0036022227401e-17 -0.733660858522097 0.000112625651147851 mirMAP -0.262819515199238 3.32707423709541e-07 NA NA NA hsa-miR-10b-5p CACNA2D2 1.54586540986745 2.64595843546465e-08 -0.735983720754496 9.24689385558017e-11 mirMAP -0.118213843777217 1.96403674484934e-11 NA NA NA hsa-miR-21-5p CADM2 1.0504925175311 2.58081295984106e-11 -0.513164073955502 5.33551314724491e-08 mirMAP;miRNATAP -0.235181589723171 1.42615784250654e-18 NA NA NA hsa-miR-10b-5p CALN1 1.54586540986745 2.64595843546465e-08 -1.21830332157704 6.71500915678341e-11 mirMAP -0.219397623105771 3.11622979763576e-14 NA NA NA hsa-miR-21-5p CALN1 1.0504925175311 2.58081295984106e-11 -1.21830332157704 6.71500915678341e-11 mirMAP -0.663524246687804 1.97213998362442e-33 NA NA NA hsa-miR-10b-5p CAMK2A 1.54586540986745 2.64595843546465e-08 -1.05483486466104 1.50460233407786e-05 mirMAP -0.180135301414051 2.43309049480753e-06 NA NA NA hsa-miR-21-3p CAMK2A 1.3484283943822 2.0036022227401e-17 -1.05483486466104 1.50460233407786e-05 MirTarget -0.516975229672593 1.3585319454321e-15 NA NA NA hsa-miR-10b-5p CAMK2B 1.54586540986745 2.64595843546465e-08 -0.332377348457309 0.0229717947145306 miRNATAP -0.101099127341402 7.37864929638483e-06 NA NA NA hsa-miR-21-5p CAMK4 1.0504925175311 2.58081295984106e-11 -0.568110852991134 0.00245766117591188 mirMAP -0.570302214418209 5.22853533819957e-24 NA NA NA hsa-miR-21-3p CAMLG 1.3484283943822 2.0036022227401e-17 -0.189270777303109 0.000628615368777211 MirTarget -0.128360015036861 1.23549842668249e-29 NA NA NA hsa-miR-21-5p CASK 1.0504925175311 2.58081295984106e-11 -0.15870763273773 0.0148621640829975 mirMAP -0.107292422143103 1.22206154174025e-11 NA NA NA hsa-miR-21-5p CASKIN1 1.0504925175311 2.58081295984106e-11 -0.741266119437974 1.13300847349267e-12 MirTarget -0.503622006084331 1.54379297083385e-72 NA NA NA hsa-miR-21-5p CCNG2 1.0504925175311 2.58081295984106e-11 -0.119917009119163 0.0350459315966934 mirMAP -0.132686298591375 2.54448310697497e-19 NA NA NA hsa-miR-21-5p CEP68 1.0504925175311 2.58081295984106e-11 -0.142173460637364 0.00544867313216442 miRNATAP -0.122796146021952 9.76761765453102e-27 NA NA NA hsa-miR-10b-5p CHD5 1.54586540986745 2.64595843546465e-08 -0.90113590757399 1.6582620793243e-06 mirMAP -0.109705595172222 0.000210642241960305 NA NA NA hsa-miR-21-3p CHD5 1.3484283943822 2.0036022227401e-17 -0.90113590757399 1.6582620793243e-06 mirMAP -0.32927857554889 6.56494694343769e-11 NA NA NA hsa-miR-21-3p CHRNA7 1.3484283943822 2.0036022227401e-17 -0.975351309732578 2.04826351497088e-10 mirMAP -0.345711308063089 5.61895488229429e-17 NA NA NA hsa-miR-21-5p CLIP4 1.0504925175311 2.58081295984106e-11 -0.298147304993758 1.35045826050285e-08 miRNAWalker2_validate -0.118135041825582 8.5031918303327e-18 NA NA NA hsa-miR-21-3p CNRIP1 1.3484283943822 2.0036022227401e-17 -0.448149340965637 3.26019369344538e-10 MirTarget -0.23942351502877 9.7764154161582e-55 NA NA NA hsa-miR-21-5p CNTFR 1.0504925175311 2.58081295984106e-11 -0.301957438565181 0.00501495799877331 miRNATAP -0.418753974590567 9.00749399229567e-45 NA NA NA hsa-miR-10b-5p CNTN2 1.54586540986745 2.64595843546465e-08 -0.502663602367604 0.00778579140951667 mirMAP -0.137911361375591 2.64364715684037e-06 NA NA NA hsa-miR-21-3p CNTNAP4 1.3484283943822 2.0036022227401e-17 -0.916217888679554 1.45853634123556e-06 MirTarget -0.280765499881515 5.46014046062039e-08 NA NA NA hsa-miR-21-5p CPEB3 1.0504925175311 2.58081295984106e-11 -0.559995199125646 7.28978945175864e-14 miRNAWalker2_validate;MirTarget;miRNATAP -0.266929167412625 3.44606061924003e-36 NA NA NA hsa-miR-21-3p CPLX2 1.3484283943822 2.0036022227401e-17 -0.91784997660098 2.11097394033194e-05 mirMAP -0.672051916436054 7.92892807718386e-35 NA NA NA hsa-miR-21-5p CRB1 1.0504925175311 2.58081295984106e-11 -0.107647254402346 0.258342656640104 mirMAP -0.178012157395448 7.21981216212367e-11 NA NA NA hsa-miR-10b-5p CSMD1 1.54586540986745 2.64595843546465e-08 -0.812038436898799 4.67053047626392e-10 MirTarget;miRNATAP -0.129075866807696 2.44181011091405e-10 27756250 miR 10b exerts oncogenic activity in human hepatocellular carcinoma cells by targeting expression of CUB and sushi multiple domains 1 CSMD1; Forty-five paired human HCC and adjacent non-tumor tissues were collected for qRT-PCR and immunohistochemistry analysis of miR-10b and CUB and Sushi multiple domains 1 CSMD1 respectively; We analyzed the clinicopathological data from these patients to further determine if there was an association between miR-10b and CSMD1; Luciferase assay was used to assess miR-10b binding to the 3'-untranslated region 3'-UTR of CSMD1 miR-10b was highly expressed in HCC tissues compared to normal tissues; Bioinformatics and luciferase reporter assay demonstrated that CSMD1 was the target gene of miR-10b; Immunocytochemical immunohistochemical and qRT-PCR data indicated that miR-10b decreased CSMD1 expression in HCC cells; We showed that miR-10b is overexpressed in HCC tissues and miR-10b mimics promoted HCC cell viability and invasion via targeting CSMD1 expression; Our findings suggest that miR-10b acts as an oncogene by targeting the tumor suppressor gene CSMD1 in HCC liver cancer hsa-miR-21-5p CSRNP3 1.0504925175311 2.58081295984106e-11 -0.289681788429539 0.0224182597798704 miRNATAP -0.262671949389234 1.64885499448985e-11 NA NA NA hsa-miR-21-3p CTNNA3 1.3484283943822 2.0036022227401e-17 -0.588891252912779 1.65555633345628e-05 MirTarget -0.300898757755952 1.50984938299552e-16 NA NA NA hsa-miR-21-5p CXXC4 1.0504925175311 2.58081295984106e-11 -0.279307540200037 0.0150265027423186 mirMAP -0.310894888079927 2.44175551744163e-19 NA NA NA hsa-miR-21-3p DGKE 1.3484283943822 2.0036022227401e-17 -0.450441971993169 3.79259816922547e-05 mirMAP -0.127066753667539 1.82503053137455e-05 NA NA NA hsa-miR-21-5p DLGAP1 1.0504925175311 2.58081295984106e-11 -0.619150050487165 1.95461189677648e-07 miRNATAP -0.383395289754208 8.51283339291332e-29 NA NA NA hsa-miR-10b-5p DLGAP2 1.54586540986745 2.64595843546465e-08 -1.13362495910633 1.82769222132595e-09 miRNATAP -0.188511070551476 2.22911024467597e-10 NA NA NA hsa-miR-21-5p DLGAP2 1.0504925175311 2.58081295984106e-11 -1.13362495910633 1.82769222132595e-09 mirMAP -0.624629437196997 3.9057368374127e-28 NA NA NA hsa-miR-21-5p DOK6 1.0504925175311 2.58081295984106e-11 -0.643390737460889 1.50221814892174e-06 mirMAP -0.452402171512683 1.65117849499281e-30 NA NA NA hsa-miR-21-5p DUSP8 1.0504925175311 2.58081295984106e-11 -0.17515174843211 0.0382928021347344 miRNAWalker2_validate;MirTarget -0.22189839167749 7.87221670188543e-20 NA NA NA hsa-miR-21-3p DYNC1I1 1.3484283943822 2.0036022227401e-17 -0.580275653356384 3.20023457773877e-06 MirTarget -0.273788963729275 7.69603466396318e-17 NA NA NA hsa-miR-21-5p EDIL3 1.0504925175311 2.58081295984106e-11 -0.618192885421041 6.79420434555256e-05 miRNAWalker2_validate;MirTarget -0.122842031565658 0.0117531187001923 NA NA NA hsa-miR-21-3p EFNA5 1.3484283943822 2.0036022227401e-17 -0.482975700052229 0.00104762446218271 mirMAP -0.179309789782236 7.63673417478275e-06 NA NA NA hsa-miR-21-5p EGFR 1.0504925175311 2.58081295984106e-11 0.375473556369618 0.0155485714375729 miRNAWalker2_validate;miRTarBase -0.118832377375515 0.0117576517085032 20113523;24012640;20048743;24198203;24331411;26563758;19597153;26026961 Thus the miR-21 inhibitor might interrupt the activity of EGFR pathways independently of PTEN status;Further the expression of miR-21 is regulated by EGFR via the activation of β-catenin and AP-1; These data indicate that a feedback loop exists between miR-21 and EGFR; These results clarify a novel association between miR-21 and EGFR in the regulation of cancer cell progression;Downregulation of miR 21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status;In radically resected NSCLC patients the expression levels of miR-21 10b in patients with EGFR mutation were much higher than those without mutation;MiR 21 overexpression is associated with acquired resistance of EGFR TKI in non small cell lung cancer;Higher expression levels of miR-21 AmiR-27a and miR-218 detected in this study suggest potential roles of these miRNAs in primary resistance to EGFR-TKI in advanced NSCLC patients with EGFR exon 19 deletion mutations;MiR 21 is an EGFR regulated anti apoptotic factor in lung cancer in never smokers; The changes in expression of some of these miRNAs including miR-21 were more remarkable in cases with EGFR mutations than in those without these mutations; In the never-smoker-derived lung adenocarcinoma cell line H3255 with mutant EGFR and high levels of p-EGFR and miR-21 antisense inhibition of miR-21 enhanced AG1478-induced apoptosis; In a never-smoker-derived adenocarcinoma cell line H441 with wild-type EGFR the antisense miR-21 not only showed the additive effect with AG1478 but also induced apoptosis by itself; These results suggest that aberrantly increased expression of miR-21 which is enhanced further by the activated EGFR signaling pathway plays a significant role in lung carcinogenesis in never-smokers as well as in smokers and is a potential therapeutic target in both EGFR-mutant and wild-type cases;Nickel may contribute to EGFR mutation and synergistically promotes tumor invasion in EGFR mutated lung cancer via nickel induced microRNA 21 expression ;progression;;;drug resistance;staging;drug resistance;tumorigenesis; glioblastoma;glioblastoma;glioblastoma;lung squamous cell cancer;lung squamous cell cancer;lung squamous cell cancer;lung cancer;lung cancer hsa-miR-21-5p EIF4A2 1.0504925175311 2.58081295984106e-11 -0.232145594809177 0.000245590662312804 miRNAWalker2_validate;miRTarBase -0.108864918862811 3.12505909929246e-18 NA NA NA hsa-miR-10b-5p ELAVL2 1.54586540986745 2.64595843546465e-08 -0.633480872187785 2.3392363579875e-05 MirTarget;miRNATAP -0.101937571297727 1.47474190837157e-05 NA NA NA hsa-miR-21-5p ELAVL4 1.0504925175311 2.58081295984106e-11 -0.637157204078504 4.13366994012396e-05 miRNAWalker2_validate -0.422847361878242 1.87297612718515e-19 NA NA NA hsa-miR-21-3p ELMO1 1.3484283943822 2.0036022227401e-17 -0.211950108658856 0.00946015236915016 MirTarget -0.135519450895813 1.28151226104797e-12 NA NA NA hsa-miR-21-5p ELOVL4 1.0504925175311 2.58081295984106e-11 -0.171602182188974 0.0311115856851339 miRNAWalker2_validate -0.176569390786384 1.1443878287098e-13 NA NA NA hsa-miR-21-3p ETV1 1.3484283943822 2.0036022227401e-17 -0.127406918040398 0.312313464120061 MirTarget -0.18533852513806 2.23661917466728e-09 NA NA NA hsa-miR-21-5p FAM126B 1.0504925175311 2.58081295984106e-11 -0.201740043202993 0.000596653679563337 miRNAWalker2_validate -0.144911711444422 2.68427149707289e-19 NA NA NA hsa-miR-21-3p FAT3 1.3484283943822 2.0036022227401e-17 -0.355479036975166 9.83051195610562e-05 MirTarget -0.145159286287096 3.50507385956745e-10 NA NA NA hsa-miR-21-5p FBXL17 1.0504925175311 2.58081295984106e-11 -0.225273298130301 6.69535449186666e-06 miRNAWalker2_validate;miRNATAP -0.11320956988366 6.33032507767722e-22 NA NA NA hsa-miR-21-5p FMR1 1.0504925175311 2.58081295984106e-11 -0.174989595580888 0.000181875579454969 miRNAWalker2_validate -0.108865843366939 2.38156077931383e-27 NA NA NA hsa-miR-21-5p FOXP2 1.0504925175311 2.58081295984106e-11 -0.582593823628155 0.00247037826961589 mirMAP -0.156678362862305 0.00953660922729456 NA NA NA hsa-miR-10b-5p GABRG1 1.54586540986745 2.64595843546465e-08 -1.55308325860899 5.19765315835172e-16 MirTarget -0.256246061083715 1.22052396163957e-17 NA NA NA hsa-miR-21-3p GAD2 1.3484283943822 2.0036022227401e-17 -0.393770341299408 0.105803129270887 MirTarget -0.433445479887827 2.95287894124971e-11 NA NA NA hsa-miR-21-5p GAD2 1.0504925175311 2.58081295984106e-11 -0.393770341299408 0.105803129270887 mirMAP -0.552666571553173 1.22998068094566e-13 NA NA NA hsa-miR-21-5p GFOD1 1.0504925175311 2.58081295984106e-11 -0.103743883242223 0.295029259772309 mirMAP -0.171341770040069 2.00614226246696e-08 NA NA NA hsa-miR-21-5p GLCCI1 1.0504925175311 2.58081295984106e-11 -0.0823006336730128 0.352914294038513 miRNAWalker2_validate;MirTarget;miRNATAP -0.217874607401214 2.41448912330539e-18 NA NA NA hsa-miR-21-5p GLIS2 1.0504925175311 2.58081295984106e-11 -0.0222500914290817 0.73655518453801 miRNATAP -0.134259520886687 1.58149425347312e-14 NA NA NA hsa-miR-21-3p GNAZ 1.3484283943822 2.0036022227401e-17 -0.25767226263674 4.85756414428777e-05 MirTarget -0.129081812778319 1.85670795820442e-19 NA NA NA hsa-miR-21-5p GPAM 1.0504925175311 2.58081295984106e-11 -0.341005823569965 4.88915423999009e-07 miRNAWalker2_validate;mirMAP -0.136627940890528 1.67993460974671e-13 NA NA NA hsa-miR-21-5p GPD1L 1.0504925175311 2.58081295984106e-11 -0.282460523791179 5.21672204438394e-05 miRNAWalker2_validate -0.132638887067449 1.19836045418045e-11 NA NA NA hsa-miR-10b-5p GRIN1 1.54586540986745 2.64595843546465e-08 -1.21467178764683 3.37485471660921e-07 mirMAP -0.22018081010092 3.38532065207601e-09 NA NA NA hsa-miR-10b-5p GRIN3A 1.54586540986745 2.64595843546465e-08 -1.17426461389859 1.05223727818142e-10 miRNATAP -0.218948499739129 1.323117203386e-14 NA NA NA hsa-miR-21-3p GRM5 1.3484283943822 2.0036022227401e-17 -0.561864673272964 0.00145874188583928 MirTarget -0.411574971801097 1.01766028127346e-18 NA NA NA hsa-miR-21-5p HAPLN1 1.0504925175311 2.58081295984106e-11 -0.791996101418164 1.20626116359587e-05 miRNAWalker2_validate -0.57501061406315 1.42672109182052e-26 NA NA NA hsa-miR-21-3p HIPK2 1.3484283943822 2.0036022227401e-17 -0.363654012936875 5.64577716751019e-06 mirMAP -0.141011743108518 7.60800111071026e-17 NA NA NA hsa-miR-21-5p HMGB3 1.0504925175311 2.58081295984106e-11 0.110904170774731 0.0931861531179716 miRNAWalker2_validate -0.121927776772609 9.10050740075751e-12 NA NA NA hsa-miR-21-3p HOOK1 1.3484283943822 2.0036022227401e-17 -0.643436399508218 0.000342617808153987 MirTarget -0.253142665297049 2.01532557340571e-07 NA NA NA hsa-miR-21-5p IDS 1.0504925175311 2.58081295984106e-11 -0.445638272693007 3.09768620939665e-05 mirMAP -0.183620792120582 1.02817224208802e-09 NA NA NA hsa-miR-10b-5p IGSF1 1.54586540986745 2.64595843546465e-08 -0.9397340491218 3.97973216458896e-08 miRNAWalker2_validate -0.123204439431774 4.70746336114285e-06 NA NA NA hsa-miR-21-5p IL12A 1.0504925175311 2.58081295984106e-11 -0.214937360433277 0.0339831648305032 MirTarget -0.14779928812961 2.62305046009305e-06 NA NA NA hsa-miR-21-5p INPP4B 1.0504925175311 2.58081295984106e-11 -0.230522157520723 0.0269303851089347 mirMAP -0.1197449700789 0.00022946350601354 NA NA NA hsa-miR-21-3p INSIG1 1.3484283943822 2.0036022227401e-17 -0.277687661263184 0.000412111728527532 MirTarget -0.149200474870139 6.80793739787062e-14 NA NA NA hsa-miR-10b-5p IPCEF1 1.54586540986745 2.64595843546465e-08 -0.637962579640793 2.88980073139746e-06 miRNAWalker2_validate -0.109802235839446 2.92283312596912e-07 NA NA NA hsa-miR-21-3p IPCEF1 1.3484283943822 2.0036022227401e-17 -0.637962579640793 2.88980073139746e-06 MirTarget -0.156133269035039 2.60159837910312e-05 NA NA NA hsa-miR-21-5p JMY 1.0504925175311 2.58081295984106e-11 -0.187444686363918 0.000120412578133134 miRNAWalker2_validate;mirMAP -0.11042748697577 7.06004584727729e-23 NA NA NA hsa-miR-21-5p JPH1 1.0504925175311 2.58081295984106e-11 -0.319996540716788 0.0305372995080731 miRNAWalker2_validate;miRNATAP -0.112985525859259 0.0149441630081063 NA NA NA hsa-miR-21-3p KBTBD11 1.3484283943822 2.0036022227401e-17 -0.646306834504795 1.34510641261809e-11 mirMAP -0.251875316338712 1.32920962797583e-26 NA NA NA hsa-miR-21-5p KBTBD6 1.0504925175311 2.58081295984106e-11 -0.237145657072579 3.83297854058141e-05 miRNAWalker2_validate;MirTarget -0.178328468398766 1.92097037483054e-37 NA NA NA hsa-miR-21-5p KBTBD7 1.0504925175311 2.58081295984106e-11 -0.289087246425916 0.000559435751981594 miRNAWalker2_validate -0.20239814928466 3.73098236062684e-16 NA NA NA hsa-miR-21-5p KCNA1 1.0504925175311 2.58081295984106e-11 -0.432371976028936 0.024549639900942 miRNATAP -0.224826785541224 0.000186528223295262 NA NA NA hsa-miR-21-5p KCNA3 1.0504925175311 2.58081295984106e-11 0.0194100307213929 0.900813941733768 miRNATAP -0.151476601876622 0.00183425245337139 NA NA NA hsa-miR-21-3p KCNC1 1.3484283943822 2.0036022227401e-17 -0.325288503431226 0.0045862562686505 mirMAP -0.260077164555347 1.83255634643314e-18 NA NA NA hsa-miR-21-5p KCNK3 1.0504925175311 2.58081295984106e-11 -0.747942390442109 8.60057476840747e-06 mirMAP -0.61780697436512 4.2028734188096e-36 NA NA NA hsa-miR-21-3p KIAA1211 1.3484283943822 2.0036022227401e-17 -0.193969575509712 0.0105414627250678 MirTarget -0.133877196317092 1.36067960298239e-13 NA NA NA hsa-miR-21-3p KIAA1462 1.3484283943822 2.0036022227401e-17 -0.0787460222020364 0.289143757049348 MirTarget -0.11048992770923 5.14093037105579e-10 NA NA NA hsa-miR-21-5p KIAA1671 1.0504925175311 2.58081295984106e-11 -0.509910000108656 4.48563811037274e-10 mirMAP -0.108651593551254 3.92803204557817e-06 NA NA NA hsa-miR-21-3p KIF5C 1.3484283943822 2.0036022227401e-17 -0.22069362076783 0.0180586616004811 mirMAP -0.154774027461734 5.92139125015901e-12 NA NA NA hsa-miR-21-3p KIRREL3 1.3484283943822 2.0036022227401e-17 -0.367552973375349 0.0196771366398727 MirTarget -0.167819620092444 8.84592741236252e-05 NA NA NA hsa-miR-21-5p KLF12 1.0504925175311 2.58081295984106e-11 -0.157377623815232 0.0190592441551774 mirMAP -0.170389769168257 5.59258220415348e-22 NA NA NA hsa-miR-21-5p KSR2 1.0504925175311 2.58081295984106e-11 -1.40515906446051 3.09034091577852e-15 mirMAP -0.778186125155932 1.19398343897934e-51 NA NA NA hsa-miR-21-3p L2HGDH 1.3484283943822 2.0036022227401e-17 -0.262447063501482 7.98206523762807e-07 MirTarget -0.10299444298209 2.07201016725964e-15 NA NA NA hsa-miR-21-5p LANCL1 1.0504925175311 2.58081295984106e-11 -0.221415064446631 0.000506728956451678 MirTarget -0.105734226283062 3.31758485140966e-11 NA NA NA hsa-miR-21-3p LANCL2 1.3484283943822 2.0036022227401e-17 -0.0492899360851631 0.52632513690453 MirTarget -0.103250994289433 4.06305931608217e-08 NA NA NA hsa-miR-21-5p LIFR 1.0504925175311 2.58081295984106e-11 -0.385582205083604 2.53026450447379e-05 miRNAWalker2_validate -0.132291774046052 1.09714642870804e-07 NA NA NA hsa-miR-21-3p LONRF2 1.3484283943822 2.0036022227401e-17 -0.336492098006701 0.000122708148335347 mirMAP -0.142205259591123 3.49513457816687e-11 NA NA NA hsa-miR-21-5p LONRF2 1.0504925175311 2.58081295984106e-11 -0.336492098006701 0.000122708148335347 miRNAWalker2_validate -0.189870255774996 8.90045612819168e-15 NA NA NA hsa-miR-21-3p LRRC27 1.3484283943822 2.0036022227401e-17 -0.188725682220979 0.000328691748442098 mirMAP -0.100633012758528 1.19703660096e-16 NA NA NA hsa-miR-21-3p LYNX1 1.3484283943822 2.0036022227401e-17 -0.49759661084158 2.4583569256816e-07 mirMAP -0.175372744590853 9.37366460922259e-13 NA NA NA hsa-miR-21-5p LYRM7 1.0504925175311 2.58081295984106e-11 -0.115166815412413 0.0180822614500249 miRNAWalker2_validate -0.125819502010951 4.41161135165989e-28 NA NA NA hsa-miR-21-3p MAGEL2 1.3484283943822 2.0036022227401e-17 -0.441021220575961 1.28835289469785e-05 MirTarget -0.269707686492522 9.86949245778261e-25 NA NA NA hsa-miR-10b-5p MARCH4 1.54586540986745 2.64595843546465e-08 -0.735136463441775 0.000505578162281508 mirMAP -0.143810091537522 1.56889075429438e-05 NA NA NA hsa-miR-21-5p MARCKS 1.0504925175311 2.58081295984106e-11 -0.105877798606951 0.190059303769791 miRNAWalker2_validate;miRTarBase -0.143908434517577 3.43031120392992e-14 19302977 MicroRNA 21 directly targets MARCKS and promotes apoptosis resistance and invasion in prostate cancer cells drug resistance prostate cancer hsa-miR-21-5p MBLAC2 1.0504925175311 2.58081295984106e-11 -0.144093630630752 0.00893604477970422 MirTarget -0.129788634043502 2.17063151332647e-16 NA NA NA hsa-miR-21-5p MBP 1.0504925175311 2.58081295984106e-11 -0.886389834771984 3.6414649524998e-05 mirMAP -0.170146737658403 0.0105883072545903 NA NA NA hsa-miR-21-5p MDGA2 1.0504925175311 2.58081295984106e-11 -0.754948764002094 9.61356848028149e-08 miRNATAP -0.35226012473411 3.05602960182738e-16 NA NA NA hsa-miR-21-5p MEGF11 1.0504925175311 2.58081295984106e-11 -0.329135226622426 0.0162226384420784 mirMAP -0.320361148316608 2.97996442234047e-15 NA NA NA hsa-miR-21-5p MIB1 1.0504925175311 2.58081295984106e-11 -0.197304309194696 0.00153060773556678 miRNAWalker2_validate;mirMAP -0.116776532207112 1.86852217406626e-14 NA NA NA hsa-miR-21-3p MLC1 1.3484283943822 2.0036022227401e-17 -0.47181954997432 2.51723102446225e-05 MirTarget -0.172788532328353 2.49603364433596e-10 NA NA NA hsa-miR-21-5p MOAP1 1.0504925175311 2.58081295984106e-11 -0.368003334728375 1.41047632768789e-07 miRNAWalker2_validate -0.205987474173013 2.22771555814876e-30 NA NA NA hsa-miR-21-5p MRAP2 1.0504925175311 2.58081295984106e-11 -0.127101744201301 0.494782817103401 miRNAWalker2_validate -0.181066948791156 0.00190689564121909 NA NA NA hsa-miR-21-5p MTMR9 1.0504925175311 2.58081295984106e-11 -0.205234916118923 0.000122593622990093 miRNAWalker2_validate -0.134241274773015 9.82011394770466e-25 NA NA NA hsa-miR-21-3p MUM1L1 1.3484283943822 2.0036022227401e-17 -1.07011231665296 3.63260652841148e-11 MirTarget -0.346920963623207 2.02620959019485e-15 NA NA NA hsa-miR-21-5p MYCBP2 1.0504925175311 2.58081295984106e-11 -0.354075360345454 2.76928595468988e-06 miRNAWalker2_validate -0.161032250080632 4.70297695422002e-15 NA NA NA hsa-miR-21-5p N4BP2L1 1.0504925175311 2.58081295984106e-11 -0.283786222271528 1.15356029112066e-06 MirTarget -0.106953230459826 1.08174791084735e-10 NA NA NA hsa-miR-21-3p N6AMT1 1.3484283943822 2.0036022227401e-17 -0.128849861689275 0.0321339369639707 mirMAP -0.10542610611105 1.2312289459153e-11 NA NA NA hsa-miR-21-3p NAP1L5 1.3484283943822 2.0036022227401e-17 -0.390867548362005 5.39221497501935e-08 MirTarget -0.163653108787241 1.16283816542992e-21 NA NA NA hsa-miR-21-3p NAV3 1.3484283943822 2.0036022227401e-17 -0.427731682192376 4.09634114034434e-06 MirTarget -0.124564645837263 5.71344746026169e-07 25579119 We identify NAV3 as a potential target of miR-21-3p and show that knockdown of NAV3 increases resistance; Finally we use publically available transcriptomic data to demonstrate that miR-21-3p is raised while NAV3 is reduced in ovarian tumours that are resistant to platinum treatment; Our data suggest that miR-21-3p can induce cisplatin resistance in ovarian tumours potentially by targeting the NAV3 gene drug resistance ovarian cancer hsa-miR-21-5p NBEA 1.0504925175311 2.58081295984106e-11 -0.365452323213813 1.42551340934486e-05 miRNAWalker2_validate;miRNATAP -0.241805042283778 5.15469149787601e-24 NA NA NA hsa-miR-21-3p NCAM1 1.3484283943822 2.0036022227401e-17 -0.227850665758542 0.00678873823855233 MirTarget -0.146321374026021 2.48610893102514e-18 NA NA NA hsa-miR-21-3p NDUFA5 1.3484283943822 2.0036022227401e-17 -0.238565930687582 5.74753878122527e-06 mirMAP -0.104100782206325 2.86951104530929e-23 NA NA NA hsa-miR-21-5p NFIB 1.0504925175311 2.58081295984106e-11 -0.151336169908416 0.0298860513853996 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.142102552193434 7.18924216890823e-16 NA NA NA hsa-miR-21-5p NKD1 1.0504925175311 2.58081295984106e-11 -0.0915570732498647 0.331718005040373 mirMAP -0.21908671085636 2.66527031428981e-15 NA NA NA hsa-miR-21-5p NKIRAS1 1.0504925175311 2.58081295984106e-11 -0.260323923333749 2.34217126965413e-07 MirTarget -0.124169332057945 6.1922822048428e-22 NA NA NA hsa-miR-21-5p NPAS3 1.0504925175311 2.58081295984106e-11 -0.125692939469134 0.041712899350652 miRNATAP -0.112765602983987 1.04845858139923e-13 NA NA NA hsa-miR-21-5p NTRK2 1.0504925175311 2.58081295984106e-11 -0.686181111372964 1.63868289231844e-08 mirMAP -0.236108791238634 4.9068404718365e-13 NA NA NA hsa-miR-21-3p NTRK3 1.3484283943822 2.0036022227401e-17 -0.12437098154002 0.057887624859589 mirMAP -0.108912563833562 1.12845978745641e-12 NA NA NA hsa-miR-21-5p NTRK3 1.0504925175311 2.58081295984106e-11 -0.12437098154002 0.057887624859589 mirMAP -0.136696635785588 5.89376526223852e-15 NA NA NA hsa-miR-21-3p ONECUT2 1.3484283943822 2.0036022227401e-17 0.0592720542394012 0.626992163670103 mirMAP -0.143099185603855 1.31594761807282e-05 NA NA NA hsa-miR-21-5p PAIP2B 1.0504925175311 2.58081295984106e-11 -0.491988132647813 6.77633741539464e-07 miRNATAP -0.251056710147164 2.15997607190676e-17 NA NA NA hsa-miR-21-3p PAX5 1.3484283943822 2.0036022227401e-17 0.0861399693951088 0.662824727890402 mirMAP -0.229289123632861 1.49824757168947e-05 NA NA NA hsa-miR-21-3p PCDH19 1.3484283943822 2.0036022227401e-17 -0.212405379091035 0.0218694223685577 MirTarget -0.181312864287522 2.24122009172721e-14 NA NA NA hsa-miR-21-3p PCDHA1 1.3484283943822 2.0036022227401e-17 -0.368534379936063 0.0086538280432064 MirTarget -0.184715971025825 9.3757064499156e-07 NA NA NA hsa-miR-21-3p PCDHA11 1.3484283943822 2.0036022227401e-17 0.00317921165098112 0.987847625345023 MirTarget -0.137949851515994 0.0152926718197804 NA NA NA hsa-miR-21-3p PCDHA12 1.3484283943822 2.0036022227401e-17 -0.0873549149680128 0.533938036589765 MirTarget -0.122312675394872 0.0013407096295447 NA NA NA hsa-miR-21-3p PCDHA2 1.3484283943822 2.0036022227401e-17 -0.154236866402834 0.327890516772162 MirTarget -0.203721878810021 1.76415253429891e-06 NA NA NA hsa-miR-21-3p PCDHA3 1.3484283943822 2.0036022227401e-17 -0.259602936771717 0.0811179735338314 MirTarget -0.118364110953796 0.00331635926770127 NA NA NA hsa-miR-21-3p PCDHA4 1.3484283943822 2.0036022227401e-17 -0.501356474470202 0.0110890878172245 MirTarget -0.142965280309127 0.00760497051209298 NA NA NA hsa-miR-21-3p PCDHA5 1.3484283943822 2.0036022227401e-17 -0.377891344173821 0.00862030491189109 MirTarget -0.264585428776282 6.31318212215358e-12 NA NA NA hsa-miR-21-3p PCDHA6 1.3484283943822 2.0036022227401e-17 -0.396165083257366 0.0226732073058121 MirTarget -0.184440402487628 9.29152655019457e-05 NA NA NA hsa-miR-21-3p PCDHA7 1.3484283943822 2.0036022227401e-17 -0.547188899694223 4.52397211968886e-05 MirTarget -0.126499030168982 0.000565182998556647 NA NA NA hsa-miR-21-3p PCDHA9 1.3484283943822 2.0036022227401e-17 -0.709623332639829 0.000260969086220726 MirTarget -0.187450241770963 0.00040481724390396 NA NA NA hsa-miR-21-5p PCSK6 1.0504925175311 2.58081295984106e-11 -0.925086438693064 3.15697952025663e-10 MirTarget;miRNATAP -0.236721660291369 1.86265597598784e-07 NA NA NA hsa-miR-21-3p PDP2 1.3484283943822 2.0036022227401e-17 -0.264150351728376 3.72884614189655e-05 MirTarget -0.120056987738379 9.70671121060301e-14 NA NA NA hsa-miR-21-5p PER2 1.0504925175311 2.58081295984106e-11 -0.240715751962737 6.0665790241295e-05 MirTarget -0.132581815740464 8.19875858215508e-15 NA NA NA hsa-miR-21-5p PER3 1.0504925175311 2.58081295984106e-11 -0.555621926560449 4.66702527917726e-11 miRNAWalker2_validate -0.159315752042598 5.9947352989701e-11 NA NA NA hsa-miR-21-5p PEX5L 1.0504925175311 2.58081295984106e-11 -0.619335663238299 2.17276534908085e-05 mirMAP -0.280718402007969 6.33415245953689e-10 NA NA NA hsa-miR-21-5p PFKM 1.0504925175311 2.58081295984106e-11 -0.290593861394638 8.56279220085546e-06 MirTarget -0.143446011303072 6.11570245714965e-24 NA NA NA hsa-miR-21-5p PHF6 1.0504925175311 2.58081295984106e-11 -0.0819750926172382 0.151171072716548 MirTarget;mirMAP -0.10274529084405 1.1926602433029e-12 NA NA NA hsa-miR-21-3p PHLPP2 1.3484283943822 2.0036022227401e-17 -0.295383088255838 3.01170349547581e-07 mirMAP -0.118692879674515 1.25900689857913e-18 NA NA NA hsa-miR-21-3p PHYHIPL 1.3484283943822 2.0036022227401e-17 -0.582880910715327 2.41483971552809e-09 MirTarget -0.324182685668459 9.35859230558657e-53 NA NA NA hsa-miR-21-5p PIK3R1 1.0504925175311 2.58081295984106e-11 -0.259275224308753 0.00106935451973482 miRNAWalker2_validate;MirTarget;miRNATAP -0.192193122796698 2.35557430088274e-23 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-21-5p PIP4K2B 1.0504925175311 2.58081295984106e-11 -0.181851615289208 0.00122873384117695 mirMAP -0.124775294602885 2.50842271091149e-34 NA NA NA hsa-miR-10b-5p PLCH2 1.54586540986745 2.64595843546465e-08 -0.783111334452658 1.9691829796214e-09 mirMAP -0.134806138537861 3.37516068311584e-11 NA NA NA hsa-miR-21-3p PLCXD3 1.3484283943822 2.0036022227401e-17 -0.721937286689947 6.37187188414748e-06 mirMAP -0.137160416939367 0.00175770982544819 NA NA NA hsa-miR-21-3p PPARA 1.3484283943822 2.0036022227401e-17 -0.335389759038048 2.96327925125206e-07 mirMAP -0.106860249331315 6.17473894560535e-12 22244963 In the final integrative analysis of lung cancer related miR-21-targets analysis 24 hub genes were identified by overlap calculation suggesting that miR-21 may play an important role in the development and progression of lung cancer through JAK/STAT signal pathway MAPK signaling pathway Wnt signaling pathway cell cycle PPAR signaling pathway apoptosis pathway and other pathways progression lung cancer hsa-miR-21-5p PPARA 1.0504925175311 2.58081295984106e-11 -0.335389759038048 2.96327925125206e-07 miRNAWalker2_validate;miRTarBase;miRNATAP -0.11018993610431 8.20918004042089e-10 22244963 In the final integrative analysis of lung cancer related miR-21-targets analysis 24 hub genes were identified by overlap calculation suggesting that miR-21 may play an important role in the development and progression of lung cancer through JAK/STAT signal pathway MAPK signaling pathway Wnt signaling pathway cell cycle PPAR signaling pathway apoptosis pathway and other pathways progression lung cancer hsa-miR-21-3p PPARGC1A 1.3484283943822 2.0036022227401e-17 -0.10013745853575 0.33129149366172 mirMAP -0.113568170966798 2.81293205334978e-05 NA NA NA hsa-miR-21-5p PPFIA4 1.0504925175311 2.58081295984106e-11 -0.314552060489406 0.00327681375564529 miRNAWalker2_validate -0.214316382147153 4.36650074034371e-11 NA NA NA hsa-miR-21-5p PPIF 1.0504925175311 2.58081295984106e-11 -0.144644009312107 0.0748430302545273 miRNAWalker2_validate -0.101588005740477 3.5783040278114e-06 NA NA NA hsa-miR-21-5p PPM1L 1.0504925175311 2.58081295984106e-11 -0.486425204824598 5.55955313078931e-06 miRNAWalker2_validate -0.204711891718498 3.74665604938713e-10 NA NA NA hsa-miR-21-5p PPP1R16B 1.0504925175311 2.58081295984106e-11 -0.527408811546307 1.18417163378549e-05 mirMAP -0.247001239246443 1.57652098606621e-11 NA NA NA hsa-miR-21-3p PPP1R1A 1.3484283943822 2.0036022227401e-17 -0.958445294160461 2.80329689655815e-10 MirTarget -0.485824534555722 2.07980409751165e-35 NA NA NA hsa-miR-21-5p PPP3CA 1.0504925175311 2.58081295984106e-11 -0.373235846566351 7.56900657293056e-08 miRNATAP -0.130424810796755 2.20070954535807e-12 NA NA NA hsa-miR-21-5p PRKCE 1.0504925175311 2.58081295984106e-11 -0.435078897352525 2.43836196620233e-06 miRNAWalker2_validate -0.251627359565709 1.17020373706199e-21 NA NA NA hsa-miR-21-3p PRRG3 1.3484283943822 2.0036022227401e-17 -0.401799575629142 0.0453639786424326 mirMAP -0.231177817833327 1.92490285656231e-05 NA NA NA hsa-miR-21-5p PTCH1 1.0504925175311 2.58081295984106e-11 -0.132480074128606 0.192501865765271 mirMAP -0.211093439309103 2.37633734847505e-13 NA NA NA hsa-miR-21-5p PTGFR 1.0504925175311 2.58081295984106e-11 -0.540035302564516 0.000975822554466034 miRNAWalker2_validate -0.276530616548992 5.58349391099745e-08 NA NA NA hsa-miR-10b-5p PTPRT 1.54586540986745 2.64595843546465e-08 -1.26869586166531 7.57841447656641e-15 miRNAWalker2_validate;mirMAP -0.180921784406605 1.11245437106782e-12 NA NA NA hsa-miR-21-5p PTPRT 1.0504925175311 2.58081295984106e-11 -1.26869586166531 7.57841447656641e-15 mirMAP -0.797041517302948 6.37332075797264e-71 NA NA NA hsa-miR-21-5p RAB11FIP2 1.0504925175311 2.58081295984106e-11 -0.291509608716314 5.28928624638561e-07 miRNAWalker2_validate -0.136949981828519 3.29047375180848e-18 NA NA NA hsa-miR-21-3p RAB11FIP4 1.3484283943822 2.0036022227401e-17 -0.540057855724879 2.23674797765286e-08 mirMAP -0.272796623738059 1.94467395040999e-30 NA NA NA hsa-miR-21-3p RAB18 1.3484283943822 2.0036022227401e-17 -0.334029636684512 5.85943171958537e-09 MirTarget -0.1026009580497 4.00147002147573e-20 NA NA NA hsa-miR-21-5p RAB30 1.0504925175311 2.58081295984106e-11 -0.209775824653343 0.00977457020985865 mirMAP -0.113784279548182 4.30310479139862e-06 NA NA NA hsa-miR-21-5p RAB3B 1.0504925175311 2.58081295984106e-11 0.0285245059710855 0.867235233448252 mirMAP -0.144348315006051 0.00659874351872088 NA NA NA hsa-miR-21-5p RALGPS1 1.0504925175311 2.58081295984106e-11 -0.258022404685509 1.00795534840159e-06 mirMAP -0.193319133312229 9.01817327528575e-49 NA NA NA hsa-miR-10b-5p RAP1GAP2 1.54586540986745 2.64595843546465e-08 -0.388680049321374 0.00148559950985832 mirMAP -0.105353661998804 2.59691518543633e-08 NA NA NA hsa-miR-21-5p RASGRP1 1.0504925175311 2.58081295984106e-11 -0.461228311355649 9.75402712538101e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.209857300737546 6.88556700859861e-09 NA NA NA hsa-miR-21-3p REEP1 1.3484283943822 2.0036022227401e-17 -0.21044611259681 0.0170098758751613 MirTarget -0.187438406329102 7.81091441505866e-17 NA NA NA hsa-miR-21-3p RNF144A 1.3484283943822 2.0036022227401e-17 -0.223863463562831 0.000689567189506287 mirMAP -0.143543254077769 3.38031380424491e-20 NA NA NA hsa-miR-21-3p RRAGB 1.3484283943822 2.0036022227401e-17 -0.243837028640893 1.02582020466936e-06 MirTarget -0.13041808612003 3.08300294928235e-37 NA NA NA hsa-miR-21-3p RTN3 1.3484283943822 2.0036022227401e-17 -0.31395670146861 3.8860466716492e-06 MirTarget -0.146803114954939 4.81403782086128e-39 NA NA NA hsa-miR-21-5p RUFY3 1.0504925175311 2.58081295984106e-11 -0.261130523548589 3.72002658101746e-05 miRNAWalker2_validate -0.116067020001459 2.3024733997506e-17 NA NA NA hsa-miR-21-5p SAMD5 1.0504925175311 2.58081295984106e-11 -0.312026167088983 0.00676160573456063 miRNAWalker2_validate -0.18283676771492 3.42276539091039e-07 NA NA NA hsa-miR-21-5p SAMD8 1.0504925175311 2.58081295984106e-11 -0.283172435105144 0.00374888766676994 mirMAP -0.102437913703054 0.000617954895046478 NA NA NA hsa-miR-21-5p SASH1 1.0504925175311 2.58081295984106e-11 -0.343138665104062 2.88016197509997e-06 miRNAWalker2_validate;MirTarget -0.163897485534976 2.74923434805187e-16 NA NA NA hsa-miR-21-5p SATB1 1.0504925175311 2.58081295984106e-11 -0.413697338765004 9.04719645896809e-08 MirTarget;miRNATAP -0.25522424949967 4.79265994106128e-36 27107063 SATB1 is Down regulated in Clear Cell Renal Cell Carcinoma and Correlates with miR 21 5p Overexpression and Poor Prognosis; This study aimed to determine the expression levels of SATB1 as well as miR-21-5p -the post-transcriptional repressor of SATB1 expression- in clear cell renal cell carcinoma ccRCC and to investigate their association with the progression of ccRCC; Immunohistochemistry and quantitative polymerase chain reaction were used to assess the expression of SATB1 protein and mRNA as well as miR-21-5p in tumor and matched normal kidney tissues collected from 56 ccRCC patients; SATB1 mRNA level was down-regulated in ccRCC tissue and inversely correlated with the content of miR-21-5p; Down-regulation of SATB1 mRNA and up-regulation of miR-21-5p were associated with shorter patient survival; Decreased expression of SATB1 in ccRCC may result from over-expressed miR-21-5p worse prognosis;progression;poor survival kidney renal cell cancer hsa-miR-21-3p SCAI 1.3484283943822 2.0036022227401e-17 -0.277117557024941 7.61464582549049e-06 MirTarget -0.160195162069728 7.78163607397152e-27 NA NA NA hsa-miR-21-5p SCML2 1.0504925175311 2.58081295984106e-11 -0.00620039542346462 0.942436558571552 MirTarget;miRNATAP -0.240219837320197 1.02324928574819e-20 NA NA NA hsa-miR-21-5p SCN8A 1.0504925175311 2.58081295984106e-11 -0.342374573368462 0.0152513155710661 miRNATAP -0.279780594117803 9.69252638392097e-11 NA NA NA hsa-miR-21-5p SEC14L5 1.0504925175311 2.58081295984106e-11 -0.784275821093134 9.17109295785224e-06 mirMAP -0.256722906614919 3.7310450691655e-06 NA NA NA hsa-miR-21-5p SERPINI1 1.0504925175311 2.58081295984106e-11 -0.811105258131413 9.01706463193578e-09 miRNAWalker2_validate -0.287112829992799 6.87011471922936e-11 22464652 MicroRNA 21 inhibits Serpini1 a gene with novel tumour suppressive effects in gastric cancer; Molecular techniques include microRNA microarrays cDNA microarrays qRT-PCR for miR and mRNA expression transfection of MKN28 with miR-21 inhibitor or Serpini1 followed by Western blotting cell cycle analysis by flow cytometry and luciferase reporter assay; This search identified Serpini1 as a putative miR-21 target; Luciferase assays demonstrated direct interaction between miR-21 and Serpini1 3'UTR miR-21 and Serpini1 expression levels were inversely correlated in a subgroup of gastric cancers suggesting a regulatory mechanism that included both of these molecules; Taken together these data suggest that in a subgroup of gastric cancers miR-21 is upregulated inducing downregulation of Serpini1 which in turn releases the G1-S transition checkpoint with the end result being increased tumour growth gastric cancer hsa-miR-21-5p SEZ6L 1.0504925175311 2.58081295984106e-11 -0.461373554147156 0.00255862523537753 miRNATAP -0.547369611703971 1.73194920979618e-35 NA NA NA hsa-miR-21-5p SFXN1 1.0504925175311 2.58081295984106e-11 -0.110169374321768 0.0288458211648728 miRNAWalker2_validate -0.108789407938724 8.3128022603272e-23 NA NA NA hsa-miR-21-3p SGCD 1.3484283943822 2.0036022227401e-17 -0.615686119216908 6.98733992692406e-09 mirMAP -0.146841898651537 2.02780862537972e-07 NA NA NA hsa-miR-21-5p SH3BGRL2 1.0504925175311 2.58081295984106e-11 -0.262649260799769 5.12556687455015e-05 mirMAP -0.133577429181066 3.38599493519575e-13 NA NA NA hsa-miR-10b-5p SHISA7 1.54586540986745 2.64595843546465e-08 -0.687995227789349 2.96550280328725e-08 miRNATAP -0.130129965826082 4.83917471245127e-12 NA NA NA hsa-miR-21-3p SLC1A2 1.3484283943822 2.0036022227401e-17 -0.678683005785325 8.71817237962323e-07 mirMAP -0.348927668371887 1.28838607938967e-25 NA NA NA hsa-miR-10b-5p SLC24A4 1.54586540986745 2.64595843546465e-08 -0.900896361634604 7.96092378819533e-08 MirTarget -0.147509653195686 2.1821797916166e-08 NA NA NA hsa-miR-21-5p SLC30A10 1.0504925175311 2.58081295984106e-11 -0.441939796055355 2.31608953092907e-07 MirTarget -0.185633375967957 1.88856259261e-12 NA NA NA hsa-miR-21-5p SLC9A6 1.0504925175311 2.58081295984106e-11 -0.356244449389569 6.6188187319312e-09 miRNAWalker2_validate;miRNATAP -0.166026417528454 5.4048929917626e-27 NA NA NA hsa-miR-21-3p SMAD7 1.3484283943822 2.0036022227401e-17 -0.306923934978072 7.06110046856494e-08 MirTarget -0.114394884618655 2.26301626796383e-17 23372687;27185036;26531758 Furthermore the expression of MSH2 and SMAD7 two important molecules involving TGF-β pathway was restored following miR-21 knockdown in both MCF-7 and Hs578T breast cancer cells;MicroRNA 21 Regulates Non Small Cell Lung Cancer Cell Invasion and Chemo Sensitivity through SMAD7; We performed bioinformatics analyses on the binding of microRNA-21 miR-21 to the 3'-UTR of SMAD7 mRNA and verified the biological effects of this binding using promoter luciferase reporter assay; Furthermore expression of miR-21 was found to be inhibited by Carboplatin and bioinformatics analyses showed that miR-21 targeted the 3'-UTR of SMAD7 mRNA to inhibit its translation which was confirmed by luciferase reporter assay; Carboplatin may upregulate SMAD7 through suppression of miR-21 to inhibit TGFβ receptor signaling mediated NSCLC cell invasion;MicroRNA 21 induces breast cancer cell invasion and migration by suppressing smad7 via EGF and TGF β pathways; The present study was undertaken to determine the association of miR-21 smad7 EGF and TGF-β with breast cancer cell invasion and migration and to identify the molecular mechanisms involved using immunohistochemistry and western blot analysis; Smad7 was confirmed to be a direct target of miR-21 by luciferase reporter and western blot assays; The downregulation of smad7 by miR-21 or sismad7 enhanced EGF-dependent invasion and migration as well as TGF-β-dependent invasion and migration; The actions of miR-21 were abrogated by expressing a modified smad7 cDNA resistant to miR-21; In conclusion our results demonstrated that plasma miR-21 levels may serve as a diagnostic marker in breast cancers whereas miR-21 promotes breast cancer cell proliferation and invasion by suppressing smad7 which enhances EGF and TGF-β pathways ;; breast cancer;lung squamous cell cancer;breast cancer hsa-miR-21-5p SMAD7 1.0504925175311 2.58081295984106e-11 -0.306923934978072 7.06110046856494e-08 miRNAWalker2_validate;MirTarget;miRNATAP -0.126701222262503 3.62596651934364e-16 23372687;27185036;26531758 Furthermore the expression of MSH2 and SMAD7 two important molecules involving TGF-β pathway was restored following miR-21 knockdown in both MCF-7 and Hs578T breast cancer cells;MicroRNA 21 Regulates Non Small Cell Lung Cancer Cell Invasion and Chemo Sensitivity through SMAD7; We performed bioinformatics analyses on the binding of microRNA-21 miR-21 to the 3'-UTR of SMAD7 mRNA and verified the biological effects of this binding using promoter luciferase reporter assay; Furthermore expression of miR-21 was found to be inhibited by Carboplatin and bioinformatics analyses showed that miR-21 targeted the 3'-UTR of SMAD7 mRNA to inhibit its translation which was confirmed by luciferase reporter assay; Carboplatin may upregulate SMAD7 through suppression of miR-21 to inhibit TGFβ receptor signaling mediated NSCLC cell invasion;MicroRNA 21 induces breast cancer cell invasion and migration by suppressing smad7 via EGF and TGF β pathways; The present study was undertaken to determine the association of miR-21 smad7 EGF and TGF-β with breast cancer cell invasion and migration and to identify the molecular mechanisms involved using immunohistochemistry and western blot analysis; Smad7 was confirmed to be a direct target of miR-21 by luciferase reporter and western blot assays; The downregulation of smad7 by miR-21 or sismad7 enhanced EGF-dependent invasion and migration as well as TGF-β-dependent invasion and migration; The actions of miR-21 were abrogated by expressing a modified smad7 cDNA resistant to miR-21; In conclusion our results demonstrated that plasma miR-21 levels may serve as a diagnostic marker in breast cancers whereas miR-21 promotes breast cancer cell proliferation and invasion by suppressing smad7 which enhances EGF and TGF-β pathways ;; breast cancer;lung squamous cell cancer;breast cancer hsa-miR-21-5p SOX6 1.0504925175311 2.58081295984106e-11 -0.128649486739901 0.179859567069943 MirTarget;miRNATAP -0.169995197939525 2.2805564331408e-10 NA NA NA hsa-miR-10b-5p SRCIN1 1.54586540986745 2.64595843546465e-08 -0.302524676666578 0.0133555341937778 mirMAP -0.108450925761761 6.80978335199516e-09 NA NA NA hsa-miR-21-3p SRCIN1 1.3484283943822 2.0036022227401e-17 -0.302524676666578 0.0133555341937778 MirTarget -0.218807440994199 9.58881679280911e-12 NA NA NA hsa-miR-21-5p SRI 1.0504925175311 2.58081295984106e-11 -0.147390789525051 0.0244532296651118 MirTarget -0.128155423498758 3.54267852730241e-18 NA NA NA hsa-miR-21-5p SRRM4 1.0504925175311 2.58081295984106e-11 -0.831693238541873 1.20156722220181e-05 mirMAP -0.675732100230285 1.65326625152316e-33 NA NA NA hsa-miR-21-3p ST13 1.3484283943822 2.0036022227401e-17 -0.200692906527973 0.000932710832672272 MirTarget -0.106091351900786 1.17409218562227e-24 NA NA NA hsa-miR-21-5p ST8SIA3 1.0504925175311 2.58081295984106e-11 -0.957734546325657 9.34868011399026e-08 mirMAP -0.649347572212263 4.36173177905958e-35 NA NA NA hsa-miR-21-3p STMN4 1.3484283943822 2.0036022227401e-17 -0.336133838177012 0.00508037446352286 MirTarget -0.195142964504547 3.11492361045795e-10 NA NA NA hsa-miR-21-3p STX1B 1.3484283943822 2.0036022227401e-17 -0.575153182015081 4.01120529146267e-07 mirMAP -0.362624658639331 4.91304448955651e-39 NA NA NA hsa-miR-21-5p STXBP5 1.0504925175311 2.58081295984106e-11 -0.332112784351769 0.00028702296326662 miRNAWalker2_validate -0.209748977000397 4.38001613145774e-14 NA NA NA hsa-miR-21-3p SV2B 1.3484283943822 2.0036022227401e-17 -0.898760791832047 0.000149569022499386 mirMAP -0.430999305408867 1.24467979782997e-11 NA NA NA hsa-miR-21-5p SV2B 1.0504925175311 2.58081295984106e-11 -0.898760791832047 0.000149569022499386 mirMAP -0.517690394779515 1.29306535447645e-12 NA NA NA hsa-miR-10b-5p SVOP 1.54586540986745 2.64595843546465e-08 -1.17506885692048 3.20465463088375e-07 MirTarget;miRNATAP -0.223002669783561 6.37682530457632e-10 NA NA NA hsa-miR-21-5p SYT14 1.0504925175311 2.58081295984106e-11 -0.691911251819364 8.98458853703481e-09 miRNATAP -0.27709084447933 1.34708386662156e-13 NA NA NA hsa-miR-21-5p SYT15 1.0504925175311 2.58081295984106e-11 -0.537775487374824 8.62058841288893e-10 MirTarget -0.293968908812139 1.28770782697512e-29 NA NA NA hsa-miR-21-3p TEF 1.3484283943822 2.0036022227401e-17 -0.657994693306658 2.25765430410565e-16 MirTarget -0.280326527306701 3.79349171340672e-54 NA NA NA hsa-miR-21-5p TET1 1.0504925175311 2.58081295984106e-11 -0.32640694280031 0.000352680131894529 miRNAWalker2_validate -0.277255774566943 8.28651614470572e-25 NA NA NA hsa-miR-21-5p THRB 1.0504925175311 2.58081295984106e-11 -0.472027146878641 1.2786092890432e-06 MirTarget;miRNATAP -0.258478322599679 1.98066300337996e-19 21159845 Direct interaction with THRB was shown for miR-21 and miR-146a; We observed lower levels of THRB transcripts in cell lines transfected with miR-21 -146a and -221 down-regulation of 37-48%; P < 0.0001 but not with miR-181a; The analysis of tumor/normal tissue pairs revealed down-regulation of THRB in 11 of 13 pairs 1.3- to 9.1-fold and up-regulation of miR-21 -146a -181a and -221 in almost all pairs thyroid cancer hsa-miR-21-3p TMEFF1 1.3484283943822 2.0036022227401e-17 -0.165843209251763 0.0131847103471976 MirTarget -0.1391514237231 2.6132017181457e-17 NA NA NA hsa-miR-21-5p TMEM170B 1.0504925175311 2.58081295984106e-11 -0.284013809062738 7.27682352527529e-07 mirMAP -0.192871068857312 1.66380446675554e-44 NA NA NA hsa-miR-21-3p TMEM47 1.3484283943822 2.0036022227401e-17 -0.600979743169327 7.90030704222276e-09 MirTarget -0.122438189102342 5.40233157424515e-06 NA NA NA hsa-miR-21-5p TMEM56 1.0504925175311 2.58081295984106e-11 -0.734448370607854 2.87117277016386e-10 miRNAWalker2_validate;mirMAP -0.18827883198366 1.99967651992057e-07 NA NA NA hsa-miR-21-5p TNRC6B 1.0504925175311 2.58081295984106e-11 -0.14264032553339 0.00666673288900001 miRNAWalker2_validate;miRNATAP -0.106085793450043 3.49481999435528e-18 NA NA NA hsa-miR-21-3p TNRC6C 1.3484283943822 2.0036022227401e-17 -0.177430486877034 0.00106049728245705 mirMAP -0.126881446637338 4.89548846660328e-34 NA NA NA hsa-miR-10b-5p TPPP 1.54586540986745 2.64595843546465e-08 -0.491860707904798 4.46806930339176e-05 mirMAP -0.128143385123993 1.58681277135621e-12 NA NA NA hsa-miR-21-5p TRAPPC2 1.0504925175311 2.58081295984106e-11 -0.116359119411045 0.0101735884502882 miRNAWalker2_validate -0.107205543511503 4.42861150925895e-19 NA NA NA hsa-miR-21-5p TRIM2 1.0504925175311 2.58081295984106e-11 -0.33677573869651 5.35148232030248e-07 miRNAWalker2_validate;mirMAP;miRNATAP -0.13223015871936 3.6594114148697e-15 NA NA NA hsa-miR-21-5p TSHZ1 1.0504925175311 2.58081295984106e-11 -0.195145895253811 0.00153481905006928 miRNATAP -0.141334891130298 4.45469509719455e-20 NA NA NA hsa-miR-21-5p TTC33 1.0504925175311 2.58081295984106e-11 -0.232700603279568 3.77213850680935e-06 miRNAWalker2_validate -0.125357110780225 5.0654558881752e-23 NA NA NA hsa-miR-21-5p UNC80 1.0504925175311 2.58081295984106e-11 -0.472653369064457 1.66197107160242e-05 MirTarget -0.36710841220329 1.38471658933974e-31 NA NA NA hsa-miR-21-3p USP46 1.3484283943822 2.0036022227401e-17 -0.425996810698506 2.79014237797468e-11 MirTarget -0.16962469686433 2.06732983557826e-32 NA NA NA hsa-miR-21-3p USP51 1.3484283943822 2.0036022227401e-17 -0.295482827646771 0.00145388878924431 MirTarget -0.105374609187813 2.59115113135186e-05 NA NA NA hsa-miR-21-5p VASH2 1.0504925175311 2.58081295984106e-11 0.281394374703269 0.0109642635707859 miRNAWalker2_validate -0.193246837470003 1.84139602950109e-08 NA NA NA hsa-miR-21-5p VSNL1 1.0504925175311 2.58081295984106e-11 -0.928640228255603 0.000242459186412274 MirTarget -0.545590801364214 2.79998339141906e-12 NA NA NA hsa-miR-21-3p WASF3 1.3484283943822 2.0036022227401e-17 -0.521257840853102 2.95557665726609e-10 mirMAP -0.248295550979393 1.08281124978866e-40 NA NA NA hsa-miR-10b-5p WNK2 1.54586540986745 2.64595843546465e-08 -1.00591143946255 4.04832961728424e-11 mirMAP -0.111159974698011 3.37343836683589e-06 NA NA NA hsa-miR-10b-5p WNT7B 1.54586540986745 2.64595843546465e-08 -0.918830041961131 3.77517210098989e-07 mirMAP -0.139168120977542 8.52477478967833e-07 NA NA NA hsa-miR-21-5p ZADH2 1.0504925175311 2.58081295984106e-11 -0.192673735140135 6.56665105974276e-05 miRNAWalker2_validate;mirMAP -0.109341729294079 3.01472985607581e-21 NA NA NA hsa-miR-21-5p ZBTB20 1.0504925175311 2.58081295984106e-11 -0.0704517263025557 0.518912297577961 miRNAWalker2_validate -0.1136165215619 0.000842493213345978 NA NA NA hsa-miR-21-5p ZBTB47 1.0504925175311 2.58081295984106e-11 -0.326204469427715 5.38041835296573e-07 miRNAWalker2_validate -0.164188112509787 3.13994421531149e-25 NA NA NA hsa-miR-21-3p ZMAT4 1.3484283943822 2.0036022227401e-17 -0.61837584676441 0.000626894318081522 MirTarget -0.357085982316837 1.52835159332924e-13 NA NA NA hsa-miR-21-5p ZNF208 1.0504925175311 2.58081295984106e-11 -0.156294905440689 0.413171642577437 mirMAP -0.189736675632116 0.00146323387948112 NA NA NA hsa-miR-21-3p ZNF248 1.3484283943822 2.0036022227401e-17 -0.334477135069407 2.76117090432823e-08 MirTarget -0.153211986426994 1.19561210966811e-27 NA NA NA hsa-miR-21-5p ZNF292 1.0504925175311 2.58081295984106e-11 -0.103944442236856 0.0965225647483346 miRNAWalker2_validate -0.116488277623481 4.68413699651989e-13 NA NA NA hsa-miR-21-5p ZNF680 1.0504925175311 2.58081295984106e-11 -0.0877228960066949 0.0917277982826266 MirTarget -0.101504743265605 1.55705897939985e-13 NA NA NA hsa-miR-21-5p ZNF704 1.0504925175311 2.58081295984106e-11 0.0745646034130738 0.402705332314226 MirTarget;miRNATAP -0.114082711865113 2.31732729853457e-05 NA NA NA hsa-miR-21-5p ZRANB1 1.0504925175311 2.58081295984106e-11 -0.330689908425904 8.62610610532771e-10 miRNAWalker2_validate -0.154217873636795 1.22817464045126e-34 NA NA NA