miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-106b-5p AKT3 2.80565545918114 1.14547999022566e-09 -3.32677676487603 1.45486698220293e-05 miRNATAP -0.411504731855899 9.49650030459631e-06 NA NA NA hsa-miR-142-3p AKT3 4.35304505457969 3.10014573651358e-10 -3.32677676487603 1.45486698220293e-05 miRanda -0.161022651130634 0.00933730307368185 NA NA NA hsa-miR-15a-5p AKT3 2.0535411006904 1.91108976398046e-06 -3.32677676487603 1.45486698220293e-05 miRNAWalker2_validate;miRTarBase;miRNATAP -0.374578960806042 0.000213935533400346 NA NA NA hsa-miR-15b-5p AKT3 3.32329949959268 8.40210501034588e-13 -3.32677676487603 1.45486698220293e-05 miRNATAP -0.254367737995205 0.00570754876367863 NA NA NA hsa-miR-16-5p AKT3 2.93575808220754 2.15436817162977e-10 -3.32677676487603 1.45486698220293e-05 miRNAWalker2_validate;miRTarBase;miRNATAP -0.309870666150618 0.000864570425925272 NA NA NA hsa-miR-29b-3p AKT3 0.666547117072858 0.234055379278093 -3.32677676487603 1.45486698220293e-05 miRNATAP -0.283935483475042 0.000311340903637634 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-3065-5p AKT3 2.14185373842821 0.0609400502269891 -3.32677676487603 1.45486698220293e-05 mirMAP -0.221762461081726 2.87831776854007e-06 NA NA NA hsa-miR-362-3p AKT3 0.679952485897744 0.226148468488576 -3.32677676487603 1.45486698220293e-05 miRanda -0.254988730314174 0.00123561088951897 NA NA NA hsa-miR-501-3p AKT3 1.72239979688923 0.0075900263732748 -3.32677676487603 1.45486698220293e-05 miRNATAP -0.18288683695833 0.00732967244086728 NA NA NA hsa-miR-93-5p AKT3 2.65964181833033 2.58315947526774e-08 -3.32677676487603 1.45486698220293e-05 miRNATAP -0.334744595445174 0.000214241376596223 NA NA NA hsa-miR-3065-5p ANGPT1 2.14185373842821 0.0609400502269891 -3.47334816274882 0.000413726218373548 mirMAP -0.194935917401911 0.00140590860186447 NA NA NA hsa-miR-429 ANGPT1 6.39965293994036 1.96920201593608e-18 -3.47334816274882 0.000413726218373548 miRanda -0.279235952937584 0.000108580929724725 NA NA NA hsa-miR-142-5p ANGPT2 3.95552531913424 1.49536283724079e-08 -1.01713470438614 0.176762873394308 MirTarget -0.172823318709553 0.00375234575251609 NA NA NA hsa-miR-34c-5p ANGPT2 2.64675661251039 0.0157394735757952 -1.01713470438614 0.176762873394308 miRanda -0.100737996816786 0.00938878664528883 NA NA NA hsa-miR-429 ANGPT2 6.39965293994036 1.96920201593608e-18 -1.01713470438614 0.176762873394308 miRanda -0.158088623944402 0.00406643454458116 NA NA NA hsa-miR-664a-3p ANGPT2 0.249882351950296 0.56171157318348 -1.01713470438614 0.176762873394308 mirMAP -0.285186129433036 0.00448295272730033 NA NA NA hsa-miR-221-3p ATF2 0.94082283577318 0.174749164179978 0.255006508462589 0.638329767176427 MirTarget -0.166160760729464 0.000161631962462298 NA NA NA hsa-miR-222-3p ATF2 1.54730827524553 0.0223014220569407 0.255006508462589 0.638329767176427 MirTarget -0.170301458106441 0.000153202963405891 NA NA NA hsa-miR-26a-5p ATF2 -0.352368463397074 0.362040749917446 0.255006508462589 0.638329767176427 MirTarget;miRNATAP -0.216144927184294 0.00740224566985116 NA NA NA hsa-miR-29a-5p ATF2 0.0748295222568571 0.884125894063293 0.255006508462589 0.638329767176427 MirTarget;miRNATAP -0.214540960601064 0.000346003798054337 NA NA NA hsa-miR-30e-5p ATF2 0.780047227271616 0.0346714425913016 0.255006508462589 0.638329767176427 mirMAP -0.258612320308903 0.00214347813505889 NA NA NA hsa-miR-590-3p ATF2 2.35429565068338 2.79601879608564e-06 0.255006508462589 0.638329767176427 MirTarget;miRanda;mirMAP;miRNATAP -0.225484723256455 0.000177772009229216 NA NA NA hsa-miR-320a ATF6B -0.912036444869976 0.0565555443926988 0.373796443967976 0.245736397154398 miRanda -0.104372185905726 0.00628319615149896 NA NA NA hsa-miR-16-2-3p BCL2 3.79845098071094 1.49120139344659e-13 -3.06316187948847 1.08810932834372e-05 mirMAP -0.198780086628007 0.00813011841160033 NA NA NA hsa-miR-16-5p BCL2 2.93575808220754 2.15436817162977e-10 -3.06316187948847 1.08810932834372e-05 miRNAWalker2_validate;miRTarBase -0.272628063312585 0.00124978896318138 21336967;24447552;18449891;25435430;24598659;18931683;22966344;25623762 P glycoprotein enhances radiation induced apoptotic cell death through the regulation of miR 16 and Bcl 2 expressions in hepatocellular carcinoma cells; RHepG2 cells the multidrug resistant subline of human hepatocellular carcinoma HepG2 cells expressed higher levels of Pgp as well as miR-16 and lower level of Bcl-2 than the parental cells; On the other hand ectopic mdr1 expression enhanced radiation-induced apoptosis in HepG2 cells SK-HEP-1 cells MiHa cells and furthermore induced miR-16 and suppressed its target gene Bcl-2 in HepG2 cells; Moreover the enhancement effects of Pgp and miR-16 on radiation-induced apoptosis were counteracted by overexpression of Bcl-2;To study the expression of miR-16 and bcl-2 in T lymphoblastic lymphoma/leukemia T-LBL/ALL and its relationship to prognosis; The relationship of miR-16 and bcl-2 was significantP = 0.042χ2 = 4.147; The relationship of miR-16 and bcl-2 might suggested that gene regulation may be influenced by them;miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2;We demonstrated that anti-apoptotic protein Bcl-2 was directly targeted miR-16 in paclitaxel resistant lung cancer cells; Combined overexpression of miR-16 and miR-17 greatly reduced Beclin-1 and Bcl-2 expressions respectively; miR-17 overexpression reduced cytoprotective autophagy by targeting Beclin-1 whereas overexpression of miR-16 potentiated paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2;The miR-16 expression correlated with BCL-2 protein r = 0.51 P < 0.05;MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2;The overall objective of our investigation was to assess whether miRNA-16 miR-16 is involved in the regulation of critical genes such as BCL2 that control the sensitivity of pancreatic cancer cells to apoptosis; This study showed that the ectopic overexpression of miR-16 may be therapeutically beneficial as is evidenced by impaired cell survival with concomitant attenuation of anti-apoptotic protein Bcl-2; Moreover the luciferase reporter assay suggested that miR-16 post-transcriptionally regulates Bcl-2 expression in pancreatic cancer cells through the target sites of the 3' untranslated region of this gene;miR 15a and miR 16 modulate drug resistance by targeting bcl 2 in human colon cancer cells; To investigate the reversal effect of targeted modulation of bcl-2 expression by miR-15a and miR-16 on drug resistance of human colon cancer cells ;worse prognosis;drug resistance;;;;poor survival;drug resistance liver cancer;lymphoma;gastric cancer;lung cancer;lymphoma;prostate cancer;pancreatic cancer;colon cancer hsa-miR-192-5p BCL2 1.77716187978541 0.113485496183047 -3.06316187948847 1.08810932834372e-05 miRNAWalker2_validate -0.12938914604432 0.00025104427176319 26550150 MicroRNA 192 regulates chemo resistance of lung adenocarcinoma for gemcitabine and cisplatin combined therapy by targeting Bcl 2; In this paper we try to test whether miR-192 regulates chemo-resistance in human carcinoma A549 mice model by targeting Bcl-2; MTT assay real-time RT-PCR western blotting assay were used to investigate miR-192 expression levels cell viability ratio and Bcl-2 protein expression levels; Bcl-2 mRNA and protein expression levels up-regulated in miR-192 inhibitor treated tumor; Bcl-2 is a key regulator for miR-192 related chemotherapy resistance; In this study we demonstrate that miR-192 regulates chemoresistance for gemcitabine and cisplatin combined chemotherapy in human adenocarcinoma lung cancer A549 cells and Bcl-2 is the target of miR-192 drug resistance lung cancer hsa-miR-200a-5p BCL2 6.52092140839401 5.73108242597059e-22 -3.06316187948847 1.08810932834372e-05 mirMAP -0.195494336988318 0.000366255804733623 NA NA NA hsa-miR-200b-5p BCL2 6.81954246537908 6.31100593281326e-24 -3.06316187948847 1.08810932834372e-05 mirMAP -0.203388603979853 0.000189900674957038 NA NA NA hsa-miR-200c-3p BCL2 6.47012025883743 2.64500707716408e-26 -3.06316187948847 1.08810932834372e-05 miRNAWalker2_validate;miRTarBase;mirMAP -0.20320611228092 0.000726337324039896 NA NA NA hsa-miR-21-5p BCL2 2.65163477806992 6.72089787690756e-16 -3.06316187948847 1.08810932834372e-05 miRNAWalker2_validate;miRTarBase -0.480047476048455 4.4710057406991e-05 21468550;25994220;25381586;26555418;23359184;22964582;21376256 BCL-2 up-regulation could be achieved by miR-21 overexpression which prevented T24 cells from apoptosis induced by doxorubicin; Furthermore the miR-21 induced BCL-2 up-regulation could be cancelled by the PI3K inhibitor LY294002;Meanwhile miR-21 loss reduced STAT3 and Bcl-2 activation causing an increase in the apoptosis of tumour cells in CAC mice;Changes in the sensitivity of osteosarcoma cells to CDDP were examined after transfection with miR-21 mimics or anti-miR-21 or bcl-2 siRNA in combination with CDDP;The expression of Bax Bcl-2 and miR-21 in parental and paclitaxel-resistant cells was detected by RT-PCR and Western blotting;Resveratrol induces apoptosis of pancreatic cancers cells by inhibiting miR 21 regulation of BCL 2 expression; We also used Western blot to measure BCL-2 protein levels after down-regulation of miR-21 expression; Besides down-regulation of miR-21 expression can inhibit BCL-2 expression in PANC-1 CFPAC-1 and MIA Paca-2 cells; Over-expression of miR-21 expression can reverse down-regulation of BCL-2 expression and apoptosis induced by resveratrol; In this study we demonstrated that the effect of resveratrol on apoptosis is due to inhibiting miR-21 regulation of BCL-2 expression;Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;Bcl 2 upregulation induced by miR 21 via a direct interaction is associated with apoptosis and chemoresistance in MIA PaCa 2 pancreatic cancer cells; However the roles and mechanisms of miRNA miR-21 in regulation of Bcl-2 in pancreatic cancer remain to be elucidated; Then luciferase activity was observed after miR-21 mimics and pRL-TK plasmids containing wild-type and mutant 3'UTRs of Bcl-2 mRNA were co-transfected; Cells transfected with miR-21 inhibitor revealed an opposite trend. There was a significant increase in luciferase activity in the cells transfected with the wild-type pRL-TK plasmid in contrast to those transfected with the mutant one indicating that miR-21 promotes Bcl-2 expression by binding directly to the 3'UTR of Bcl-2 mRNA; Upregulation of Bcl-2 directly induced by miR-21 is associated with apoptosis chemoresistance and proliferation of MIA PaCa-2 pancreatic cancer cells ;;;;;;drug resistance bladder cancer;colorectal cancer;sarcoma;breast cancer;pancreatic cancer;lung cancer;pancreatic cancer hsa-miR-215-5p BCL2 3.66990923176752 0.00294614570694381 -3.06316187948847 1.08810932834372e-05 miRNAWalker2_validate -0.141357634568995 9.14425263109844e-06 NA NA NA hsa-miR-24-2-5p BCL2 2.06986947133452 5.98496897647448e-05 -3.06316187948847 1.08810932834372e-05 miRNAWalker2_validate;miRTarBase -0.362853470345382 1.94710618153458e-06 NA NA NA hsa-miR-3065-5p BCL2 2.14185373842821 0.0609400502269891 -3.06316187948847 1.08810932834372e-05 mirMAP -0.167248667776853 0.000110489568744755 NA NA NA hsa-miR-338-5p BCL2 -0.108304629897487 0.894675560494607 -3.06316187948847 1.08810932834372e-05 PITA -0.15384518087035 0.00172699574421937 NA NA NA hsa-miR-33b-5p BCL2 4.77891217497671 1.33695107675057e-08 -3.06316187948847 1.08810932834372e-05 miRTarBase;mirMAP -0.121788561427641 0.00899184402309845 NA NA NA hsa-miR-365a-3p BCL2 0.25545896241765 0.654320504621012 -3.06316187948847 1.08810932834372e-05 miRNAWalker2_validate;miRTarBase -0.394898362577108 1.10607300598646e-08 NA NA NA hsa-miR-429 BCL2 6.39965293994036 1.96920201593608e-18 -3.06316187948847 1.08810932834372e-05 miRNAWalker2_validate;miRTarBase;PITA;mirMAP -0.160807368066818 0.00180825818683377 23999873;26513239;26511969 MiR 429 up regulation induces apoptosis and suppresses invasion by targeting Bcl 2 and SP 1 in esophageal carcinoma; Subsequent Western blotting and luciferase reporter assays showed that miR-429 can bind to putative binding sites within the Bcl-2 and SP1 mRNA 3' untranslated regions UTRs to reduce their expression; Up-regulation of miR-429 inhibits invasion and promotes apoptosis in EC cells by targeting Bcl-2 and SP1; Our findings suggest that Bcl-2 and SP1 may serve as major targets of miR-429;MiR 429 Induces Gastric Carcinoma Cell Apoptosis Through Bcl 2; Here we studied the levels of miR-429 and anti-apoptotic protein Bcl-2 in GC specimens; We performed bioinformatics analyses and used luciferase-reporter assay to analyze the relationship between miR-429 and Bcl-2 in GC cells; MiR-429 levels were significantly decreased and Bcl-2 levels were significantly increased in GC specimens compared to the paired adjacent non-tumor gastric tissue; Moreover the levels of miR-429 and Bcl-2 inversely correlated in GC specimens; Bioinformatics analyses showed that miR-429 targeted the 3'-UTR of Bcl-2 mRNA to inhibit its translation which was confirmed by luciferase-reporter assay;MiR 429 induces apoptosis of glioblastoma cell through Bcl 2; Here we analyzed the levels of miR-429 and anti-apoptotic protein Bcl-2 in GBM specimens; We combined bioinformatics analyses and luciferase reporter assay to determine the relationship between miR-429 and Bcl-2 in GBM cells; We found that miR-429 levels were significantly decreased and Bcl-2 levels were significantly increased in GBM specimens compared to the paired adjacent non-tumor brain tissue; Moreover the levels of miR-429 and Bcl-2 inversely correlated; MiR-429 targeted the 3'-UTR of Bcl-2 mRNA to inhibit its translation ;; esophageal cancer;gastric cancer;glioblastoma hsa-miR-582-5p BCL2 0.685177900016753 0.447761540297692 -3.06316187948847 1.08810932834372e-05 PITA -0.134818080111642 0.00230990489507861 NA NA NA hsa-miR-629-5p BCL2 1.57164125641392 0.0115716388531198 -3.06316187948847 1.08810932834372e-05 mirMAP -0.253306211867568 7.16586879182246e-05 NA NA NA hsa-miR-7-5p BCL2 3.59831747997243 0.000676336260217879 -3.06316187948847 1.08810932834372e-05 miRNAWalker2_validate;miRTarBase;mirMAP -0.1242073018915 0.00724600894737725 26464649;25862909;21750649 Western blotting was used to evaluate the effect of miR-7 on Bcl2 in A549 and H460 cells; Moreover subsequent experiments showed that BCL-2 was downregulated by miR-7 at both transcriptional and translational levels; This study further extends the biological role of miR-7 in NSCLC A549 and H460 cells and identifies BCL-2 as a novel target possibly involved in miR-7-mediated growth suppression and apoptosis induction of NSCLC cells;miR-7 overexpression correlated with diminished BCL2 expression but there was no relationship between miR-7 and EGFR expression neither in tumour samples nor in the cell lines; Of the two postulated miR-7 target genes we examined BCL2 but not EGFR seems to be a possible miR-7 target in OC;Bioinformatics predictions revealed a potential binding site of miR-7 on 3'UTR of BCL-2 and it was further confirmed by luciferase assay; Moreover subsequent experiments showed that BCL-2 was downregulated by miR-7 at both transcriptional and translational levels; These results suggest that miR-7 regulates the expression of BCL-2 through direct 3'UTR interactions ;; lung squamous cell cancer;ovarian cancer;lung squamous cell cancer hsa-miR-342-3p BCL2L1 1.31107714473009 0.0207211910724662 0.387849298249143 0.372559860651897 PITA;miRanda;miRNATAP -0.126863966321354 0.00344426702929298 NA NA NA hsa-miR-30a-5p BCL2L11 -0.768430903969183 0.320487552854215 1.51388437257284 0.000199073859655002 miRNATAP -0.123214431368197 3.55028421373142e-05 NA NA NA hsa-miR-1-3p BDNF -3.85397883903804 6.93274972711165e-06 1.9301309436685 0.15402934773225 miRTarBase;MirTarget -0.238246139789509 0.00699566300603736 NA NA NA hsa-miR-146b-5p BDNF 1.87569569182453 0.000737241069698886 1.9301309436685 0.15402934773225 miRanda -0.397605085388184 0.00388699211645475 NA NA NA hsa-let-7a-5p CCND1 0.148081801547773 0.645305441523746 0.153161422157864 0.87752763573474 TargetScan;miRNATAP -0.543758028087025 0.00245174452713361 NA NA NA hsa-miR-106a-5p CCND1 3.98693608217557 9.37722470816656e-07 0.153161422157864 0.87752763573474 MirTarget;miRNATAP -0.430943892321887 6.82894757639655e-11 NA NA NA hsa-miR-15a-5p CCND1 2.0535411006904 1.91108976398046e-06 0.153161422157864 0.87752763573474 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.345671894500985 0.00776019225008181 22922827 CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR sarcoma hsa-miR-15b-5p CCND1 3.32329949959268 8.40210501034588e-13 0.153161422157864 0.87752763573474 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.423468924188888 0.000292921876666624 NA NA NA hsa-miR-20b-5p CCND1 4.5662923200279 4.75238200639144e-05 0.153161422157864 0.87752763573474 MirTarget;miRNATAP -0.306916825629866 1.73283870424345e-10 NA NA NA hsa-miR-34a-5p CCND1 0.830377770217786 0.0477544831885907 0.153161422157864 0.87752763573474 miRNAWalker2_validate;miRTarBase;miRNATAP -0.423813778518534 0.00174350326234822 25792709;21399894 This inhibition of proliferation was associated with a decrease in cyclin D1 levels orchestrated principally by HNF-4α a target of miR-34a considered to act as a tumour suppressor in the liver;Quantitative PCR and western analysis confirmed decreased expression of two genes BCL-2 and CCND1 in docetaxel-resistant cells which are both targeted by miR-34a ; liver cancer;breast cancer hsa-miR-497-5p CCND1 -1.44150596209372 0.0225146607606395 0.153161422157864 0.87752763573474 MirTarget;miRNATAP -0.249933846887954 0.00498383887238102 21350001 Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer breast cancer hsa-miR-106a-5p CCND2 3.98693608217557 9.37722470816656e-07 -2.81051675901102 0.00139983736368543 miRNATAP -0.444958981451041 2.08537025757115e-14 NA NA NA hsa-miR-106b-5p CCND2 2.80565545918114 1.14547999022566e-09 -2.81051675901102 0.00139983736368543 miRNAWalker2_validate;miRTarBase;miRNATAP -0.309595760343179 0.00374413339981401 NA NA NA hsa-miR-10a-3p CCND2 0.970411431936568 0.31667483998251 -2.81051675901102 0.00139983736368543 mirMAP -0.203238239783698 0.000109626077062705 NA NA NA hsa-miR-130b-5p CCND2 3.74118449312296 2.92266550966038e-10 -2.81051675901102 0.00139983736368543 mirMAP -0.460499923117218 1.14695292180331e-08 NA NA NA hsa-miR-141-3p CCND2 7.30474126597325 1.45115996357606e-24 -2.81051675901102 0.00139983736368543 MirTarget;TargetScan -0.239696704303332 0.000205435786708848 NA NA NA hsa-miR-15b-5p CCND2 3.32329949959268 8.40210501034588e-13 -2.81051675901102 0.00139983736368543 miRNATAP -0.527059068245043 3.31921597840683e-07 NA NA NA hsa-miR-16-2-3p CCND2 3.79845098071094 1.49120139344659e-13 -2.81051675901102 0.00139983736368543 mirMAP -0.289719520581 0.00206680066165107 NA NA NA hsa-miR-182-5p CCND2 5.86988712704738 1.22411588571584e-15 -2.81051675901102 0.00139983736368543 miRNAWalker2_validate;miRTarBase;miRNATAP -0.278474368736704 1.61949004264047e-05 NA NA NA hsa-miR-183-5p CCND2 6.61903249270777 1.00958881445636e-16 -2.81051675901102 0.00139983736368543 miRNATAP -0.288028240113034 1.0097840608077e-06 NA NA NA hsa-miR-191-5p CCND2 1.58824208483839 0.000738859004053681 -2.81051675901102 0.00139983736368543 MirTarget -0.315151097931825 0.00313941450228982 NA NA NA hsa-miR-200a-3p CCND2 6.336081120041 4.024313571871e-16 -2.81051675901102 0.00139983736368543 MirTarget -0.414829241668513 2.52639559759353e-12 NA NA NA hsa-miR-20b-5p CCND2 4.5662923200279 4.75238200639144e-05 -2.81051675901102 0.00139983736368543 miRNATAP -0.295383995634395 4.37719472717441e-12 NA NA NA hsa-miR-224-3p CCND2 2.84876340814503 0.000179138399939161 -2.81051675901102 0.00139983736368543 mirMAP -0.216162489376406 0.00100829595274067 NA NA NA hsa-miR-28-5p CCND2 -0.815636722979196 0.0221199948901761 -2.81051675901102 0.00139983736368543 miRanda -0.428938814049462 0.00272604774130058 NA NA NA hsa-miR-3065-3p CCND2 1.89496019576082 0.0308154823923145 -2.81051675901102 0.00139983736368543 MirTarget;miRNATAP -0.206941274598462 0.000265009133802388 NA NA NA hsa-miR-3065-5p CCND2 2.14185373842821 0.0609400502269891 -2.81051675901102 0.00139983736368543 mirMAP -0.198616424838265 0.000257635954140166 NA NA NA hsa-miR-30d-3p CCND2 -0.0740421896025512 0.857423650167556 -2.81051675901102 0.00139983736368543 mirMAP -0.548341190913964 7.47249707616609e-06 NA NA NA hsa-miR-324-3p CCND2 1.51345381556672 0.0038447546677657 -2.81051675901102 0.00139983736368543 miRNAWalker2_validate -0.43719832262749 4.09891269304966e-06 NA NA NA hsa-miR-33a-3p CCND2 2.06269680799532 0.00156436055383943 -2.81051675901102 0.00139983736368543 MirTarget -0.270924955791957 0.000410846654094401 NA NA NA hsa-miR-378a-3p CCND2 1.46612141870273 0.0466660641196872 -2.81051675901102 0.00139983736368543 miRNAWalker2_validate -0.186901666998984 0.00600686499792038 NA NA NA hsa-miR-429 CCND2 6.39965293994036 1.96920201593608e-18 -2.81051675901102 0.00139983736368543 miRNATAP -0.457780562605429 2.24817157133262e-13 NA NA NA hsa-miR-497-5p CCND2 -1.44150596209372 0.0225146607606395 -2.81051675901102 0.00139983736368543 MirTarget;miRNATAP -0.272420525595686 0.000579324260115001 NA NA NA hsa-miR-550a-5p CCND2 1.21781238856895 0.0613791144699551 -2.81051675901102 0.00139983736368543 MirTarget -0.224646283844048 0.00363403467531415 NA NA NA hsa-miR-660-5p CCND2 -0.0668683798854808 0.885250178390404 -2.81051675901102 0.00139983736368543 mirMAP -0.290960137515711 0.00793054638018279 NA NA NA hsa-miR-9-3p CCND2 1.69328215716742 0.125170982657059 -2.81051675901102 0.00139983736368543 MirTarget;mirMAP;miRNATAP -0.143162485603445 0.00185116011719342 NA NA NA hsa-miR-93-5p CCND2 2.65964181833033 2.58315947526774e-08 -2.81051675901102 0.00139983736368543 miRNATAP -0.48060449639845 2.62594110203289e-06 NA NA NA hsa-miR-96-5p CCND2 5.62521466029286 1.54938806718028e-10 -2.81051675901102 0.00139983736368543 TargetScan;miRNATAP -0.24395409924335 0.000303822796805944 NA NA NA hsa-miR-27b-3p CCND3 -0.0929089601968123 0.85847352206581 -0.53759657598867 0.124370433214632 miRNAWalker2_validate -0.141758210053908 0.000190546260809965 NA NA NA hsa-miR-429 CCND3 6.39965293994036 1.96920201593608e-18 -0.53759657598867 0.124370433214632 miRNATAP -0.112877673525875 7.62633278325715e-06 NA NA NA hsa-miR-96-5p CCND3 5.62521466029286 1.54938806718028e-10 -0.53759657598867 0.124370433214632 TargetScan -0.116905111437921 9.66017245986979e-06 NA NA NA hsa-miR-125b-5p CCNE1 -2.01187572101832 0.00516480893645494 3.90668327437123 7.68546937179809e-18 miRNAWalker2_validate -0.127872185036842 0.000654725383789322 NA NA NA hsa-miR-195-5p CCNE1 -1.59182537400701 0.0169128463756769 3.90668327437123 7.68546937179809e-18 miRNAWalker2_validate;MirTarget;miRNATAP -0.11514367249823 0.00470453662143774 24402230 Furthermore through qPCR and western blot assays we showed that overexpression of miR-195-5p reduced CCNE1 mRNA and protein levels respectively breast cancer hsa-miR-26a-5p CCNE1 -0.352368463397074 0.362040749917446 3.90668327437123 7.68546937179809e-18 miRNAWalker2_validate;miRTarBase;miRNATAP -0.184731728950396 0.00988349874140469 22094936 Cell cycle regulation and CCNE1 and CDC2 were the only significant overlapping pathway and genes differentially expressed between tumors with high and low levels of miR-26a and EZH2 respectively; Low mRNA levels of EZH2 CCNE1 and CDC2 and high levels of miR-26a are associated with favorable outcome on tamoxifen breast cancer hsa-miR-497-5p CCNE1 -1.44150596209372 0.0225146607606395 3.90668327437123 7.68546937179809e-18 MirTarget;miRNATAP -0.126936185159413 0.00315358484504579 24909281;24112607;25909221 miR 497 suppresses proliferation of human cervical carcinoma HeLa cells by targeting cyclin E1; Furthermore the target effect of miR-497 on the CCNE1 was identified by dual-luciferase reporter assay system qRT-PCR and Western blotting; Over-expressed miR-497 in HeLa cells could suppress cell proliferation by targeting CCNE1;Western blot assays confirmed that overexpression of miR-497 reduced cyclin E1 protein levels; Inhibited cellular growth suppressed cellular migration and invasion and G1 cell cycle arrest were observed upon overexpression of miR-497 in cells possibly by targeting cyclin E1;The effect of simultaneous overexpression of miR-497 and miR-34a on the inhibition of cell proliferation colony formation and tumor growth and the downregulation of cyclin E1 was stronger than the effect of each miRNA alone; The synergistic actions of miR-497 and miR-34a partly correlated with cyclin E1 levels; These results indicate cyclin E1 is downregulated by both miR-497 and miR-34a which synergistically retard the growth of human lung cancer cells ;; cervical and endocervical cancer;breast cancer;lung cancer hsa-miR-28-3p CCNE2 -0.992446114847535 0.0188188359018203 4.77667612901641 6.489939090147e-18 PITA;miRNATAP -0.212700603723915 0.00739021768839842 NA NA NA hsa-miR-30a-5p CCNE2 -0.768430903969183 0.320487552854215 4.77667612901641 6.489939090147e-18 miRNATAP -0.229409802316148 5.49447336865621e-08 NA NA NA hsa-miR-140-5p CDK2 -0.634610285725923 0.126670572966239 1.42489416332317 1.62801715893662e-05 miRanda -0.121906717948301 0.00814170704237931 NA NA NA hsa-let-7a-5p CDK6 0.148081801547773 0.645305441523746 0.50406574702617 0.551236779554206 miRNAWalker2_validate;miRTarBase;TargetScan -0.645439384156813 2.08585558666525e-05 NA NA NA hsa-let-7b-5p CDK6 -0.189422992330471 0.651878220048983 0.50406574702617 0.551236779554206 miRNAWalker2_validate;miRTarBase -0.465531746051444 5.04007910683628e-05 NA NA NA hsa-miR-101-3p CDK6 -1.12421603598195 0.0200907284788457 0.50406574702617 0.551236779554206 mirMAP -0.421606618743612 1.93327021487929e-05 NA NA NA hsa-miR-106a-5p CDK6 3.98693608217557 9.37722470816656e-07 0.50406574702617 0.551236779554206 mirMAP -0.3914421268643 2.58029820594243e-12 NA NA NA hsa-miR-141-3p CDK6 7.30474126597325 1.45115996357606e-24 0.50406574702617 0.551236779554206 TargetScan;miRNATAP -0.20492670051454 0.00089997435535192 NA NA NA hsa-miR-148b-3p CDK6 1.75622244535669 8.84414356040579e-08 0.50406574702617 0.551236779554206 mirMAP -0.473118253356064 0.00117507520744895 NA NA NA hsa-miR-200a-3p CDK6 6.336081120041 4.024313571871e-16 0.50406574702617 0.551236779554206 miRNATAP -0.351978863285198 6.61784093516688e-10 24009066 microRNA 200a is an independent prognostic factor of hepatocellular carcinoma and induces cell cycle arrest by targeting CDK6 liver cancer hsa-miR-200b-3p CDK6 5.56167217794639 6.43540045061709e-16 0.50406574702617 0.551236779554206 mirMAP -0.393674008810918 1.1478210539551e-09 NA NA NA hsa-miR-20b-5p CDK6 4.5662923200279 4.75238200639144e-05 0.50406574702617 0.551236779554206 mirMAP -0.284732309778902 2.48291204663733e-12 26166554 The transfection of miR-20b into EJ cells induced G1 phase cell cycle arrest via the decreased expression of cyclin D1 CDK2 and CDK6 without affecting another G1 phase cell cycle regulator cyclin E bladder cancer hsa-miR-30a-5p CDK6 -0.768430903969183 0.320487552854215 0.50406574702617 0.551236779554206 mirMAP -0.173159552692541 0.0051696250748206 NA NA NA hsa-miR-30d-5p CDK6 0.302504510257496 0.380193536606962 0.50406574702617 0.551236779554206 mirMAP -0.498058868266233 0.00043364409008621 NA NA NA hsa-miR-30e-5p CDK6 0.780047227271616 0.0346714425913016 0.50406574702617 0.551236779554206 mirMAP -0.536440221801356 4.09131973520604e-05 NA NA NA hsa-miR-34a-5p CDK6 0.830377770217786 0.0477544831885907 0.50406574702617 0.551236779554206 miRNAWalker2_validate;miRTarBase;miRNATAP -0.36060880640799 0.00174841793217821 21702042;26104764 Molecular analyses identified Cdk6 and sirtuin SIRT-1 as being targeted by miR-34a in MI-TCC cells however inhibition of Cdk6 and SIRT-1 was not as effective as pre-miR-34a in mediating chemosensitization;The expression of microRNA 34a is inversely correlated with c MET and CDK6 and has a prognostic significance in lung adenocarcinoma patients; We found significant inverse correlations between miR-34a and c-MET R = -0.316 P = 0.028 and CDK6 expression R = -0.4582 P = 0.004 ; bladder cancer;lung cancer hsa-miR-362-5p CDK6 -1.22309034685697 0.0452665543907975 0.50406574702617 0.551236779554206 mirMAP -0.285526744495543 0.000257106653086971 NA NA NA hsa-miR-429 CDK6 6.39965293994036 1.96920201593608e-18 0.50406574702617 0.551236779554206 mirMAP;miRNATAP -0.252321841763607 3.87842873215362e-05 NA NA NA hsa-miR-497-5p CDK6 -1.44150596209372 0.0225146607606395 0.50406574702617 0.551236779554206 miRNATAP -0.311206501941814 3.48572516094014e-05 NA NA NA hsa-miR-502-3p CDK6 -0.102232623565007 0.80889202592629 0.50406574702617 0.551236779554206 PITA;miRNATAP -0.416650063741403 0.000268656241814273 NA NA NA hsa-miR-592 CDK6 2.80403350008555 0.0293520213681333 0.50406574702617 0.551236779554206 mirMAP -0.23124216841781 2.55195577436831e-07 NA NA NA hsa-miR-660-5p CDK6 -0.0668683798854808 0.885250178390404 0.50406574702617 0.551236779554206 mirMAP -0.371049523443998 0.000362174896273971 NA NA NA hsa-let-7e-5p CDKN1A -0.111012524740586 0.814744515884005 0.575565460455045 0.357582494899873 MirTarget -0.274146718755294 0.000263797572767074 NA NA NA hsa-let-7g-5p CDKN1A 0.857251702023746 0.00647597344297273 0.575565460455045 0.357582494899873 MirTarget -0.31692390865002 0.00585926212615004 NA NA NA hsa-miR-125a-5p CDKN1A -1.32352790615388 0.00714301627309467 0.575565460455045 0.357582494899873 miRNAWalker2_validate;miRTarBase -0.352961178589696 7.16598889800001e-07 NA NA NA hsa-miR-28-5p CDKN1A -0.815636722979196 0.0221199948901761 0.575565460455045 0.357582494899873 miRNAWalker2_validate;miRTarBase;MirTarget;miRanda;miRNATAP -0.54618253223586 3.67357997876153e-08 NA NA NA hsa-miR-30b-3p CDKN1A 0.169674321578618 0.766080356926625 0.575565460455045 0.357582494899873 MirTarget -0.164844746301017 0.00864162465933599 NA NA NA hsa-miR-335-5p CDKN1A 0.167216045757305 0.803897055331049 0.575565460455045 0.357582494899873 miRNAWalker2_validate -0.250609725261631 1.48353826571499e-06 NA NA NA hsa-miR-345-5p CDKN1A 2.77314563304336 4.34343702412489e-05 0.575565460455045 0.357582494899873 miRNAWalker2_validate;miRTarBase;MirTarget -0.226896440422906 9.12582037640469e-06 NA NA NA hsa-miR-423-3p CDKN1A 1.7128674316395 1.7145324528301e-05 0.575565460455045 0.357582494899873 miRNAWalker2_validate;miRTarBase -0.268279490593696 0.00252767646001539 NA NA NA hsa-miR-505-5p CDKN1A -0.548246528900629 0.331409094367131 0.575565460455045 0.357582494899873 miRNAWalker2_validate;MirTarget -0.176195799792848 0.00518737322213012 NA NA NA hsa-miR-616-5p CDKN1A 2.48416313933027 0.00318247475868827 0.575565460455045 0.357582494899873 mirMAP -0.143849376151027 0.00610419478950803 NA NA NA hsa-miR-96-5p CDKN1A 5.62521466029286 1.54938806718028e-10 0.575565460455045 0.357582494899873 miRNAWalker2_validate;miRTarBase -0.170734648939045 0.000337982107370655 26582573 Upregulation of microRNA 96 and its oncogenic functions by targeting CDKN1A in bladder cancer; Bioinformatics prediction combined with luciferase reporter assay were used to verify whether the cyclin-dependent kinase inhibitor CDKN1A was a potential target gene of miR-96; According to the data of miRTarBase CDKN1A might be a candidate target gene of miR-96; In addition luciferase reporter and Western blot assays respectively demonstrated that miR-96 could bind to the putative seed region in CDKN1A mRNA 3'UTR and significantly reduce the expression level of CDKN1A protein; Moreover we found that the inhibition of miR-96 expression remarkably decreased cell proliferation and promoted cell apoptosis of BC cell lines which was consistent with the findings observed following the introduction of CDKN1A cDNA without 3'UTR restored miR-96; Upregulation of miR-96 may contribute to aggressive malignancy partly through suppressing CDKN1A protein expression in BC cells bladder cancer hsa-miR-221-3p CDKN1B 0.94082283577318 0.174749164179978 -0.759845869565624 0.028743899515939 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.200797560518329 2.03736102209363e-13 23637992;19953484;23939688;19126397;20146005;23967190;17569667;22992757;17721077;20461750 miR-221 knockdown not only blocked cell cycle progression induced cell apoptosis and inhibited cell proliferation in-vitro but it also inhibited in-vivo tumor growth by targeting p27kip1;Based on bioinformatic analysis we found that the seed sequences of miR-221 and miR-222 coincide with each other and p27kip1 is a target for miRNA-221/222;A Slug/miR-221 network has been suggested linking miR-221 activity with the downregulation of a Slug repressor leading to Slug/miR-221 upregulation and p27Kip1 downregulation; Interference with this process can be achieved using antisense miRNA antagomiR molecules targeting miR-221 inducing the downregulation of Slug and the upregulation of p27Kip1;Moreover a series of functional assays demonstrated that mir-221 could directly inhibit cKit p27Kip1 and possibly other pivotal proteins in melanoma;Matched HCC and adjacent non-cancerous samples were assayed for the expression of miR-221 and three G1/S transition inhibitors: p27Kip1 p21WAF1/Cip1and TGF-β1 by in situ hybridization and immunohistochemistry respectively; Real time qRT-PCR was used to investigate miR-221 and p27Kip1 transcripts in different clinical stages; In result miR-221 and TGF-β1 are frequently up-regulated in HCC while p27Kip1 and p21WAF1/Cip1 proteins are frequently down-regulated; In conclusion miR-221 is important in tumorigenesis of HCC possibly by specifically down-regulating p27Kip1 a cell-cycle inhibitor;Additionally the PDGF-dependent increase in cell proliferation appears to be mediated by inhibition of a specific target of miR-221 and down-regulation of p27Kip1;miR 221 and miR 222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1; In all cell lines tested we show an inverse relationship between the expression of miR-221 and miR-222 and the cell cycle inhibitor p27Kip1; Consistently miR-221 and miR-222 knock-down through antisense LNA oligonucleotides increases p27Kip1 in PC3 cells and strongly reduces their clonogenicity in vitro;Peptide nucleic acids targeting miR 221 modulate p27Kip1 expression in breast cancer MDA MB 231 cells; Targeting miR-221 by PNA resulted in i lowering of the hybridization levels of miR-221 measured by RT-qPCR ii upregulation of p27Kip1 gene expression measured by RT-qPCR and western blot analysis;Antagonism of either microRNA 221 or 222 in glioblastoma cells also caused an increase in p27Kip1 levels and enhanced expression of the luciferase reporter gene fused to the p27Kip1 3'UTR;MiR 221 and MiR 222 alterations in sporadic ovarian carcinoma: Relationship to CDKN1B CDKNIC and overall survival; miR-221 and miR-222 negatively regulate expression of CDKN1B p27 and CDKN1C p57 two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas; In contrast CDKN1B expression was not associated with miR-221 or miR-222 expression progression;;;;staging;tumorigenesis;;;;;poor survival breast cancer;glioblastoma;breast cancer;melanoma;liver cancer;pancreatic cancer;prostate cancer;breast cancer;glioblastoma;ovarian cancer hsa-miR-222-3p CDKN1B 1.54730827524553 0.0223014220569407 -0.759845869565624 0.028743899515939 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.203256369475779 3.47768078668867e-13 24895988;19953484;26912358;24137356;17569667;27282281;20461750 MiR-222 plays an important role in the tumorigenesis of CC possibly by specifically down-regulating p27Kip1 and PTEN;Based on bioinformatic analysis we found that the seed sequences of miR-221 and miR-222 coincide with each other and p27kip1 is a target for miRNA-221/222;Besides microvesicle marker characterization we evidenced that miR-222 exosomal expression mostly reflected its abundance in the cells of origin correctly paralleled by repression of its target genes such as p27Kip1 and induction of the PI3K/AKT pathway thus confirming its functional implication in cancer;miR 222 is upregulated in epithelial ovarian cancer and promotes cell proliferation by downregulating P27kip1; miR-222 upregulation induced an enhancement of ovarian cancer cell proliferation potential possibly by downregulating its target P27Kip1; A bioinformatic analysis showed that the 3'-UTR of the P27Kip1 mRNA contained a highly-conserved putative miR-222 binding site; Luciferase reporter assays demonstrated that P27Kip1 was a direct target of miR-222; Consistently there was an inverse correlation between the P27Kip1 and miR-222 expression levels in the ovarian cancer cell lines and tissues;miR 221 and miR 222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1; In all cell lines tested we show an inverse relationship between the expression of miR-221 and miR-222 and the cell cycle inhibitor p27Kip1; Consistently miR-221 and miR-222 knock-down through antisense LNA oligonucleotides increases p27Kip1 in PC3 cells and strongly reduces their clonogenicity in vitro;miR 222 confers the resistance of breast cancer cells to Adriamycin through suppression of p27kip1 expression; Immunofluorescence showed that miR-222 altered the subcellular location of p27kip1 in nucleus; The results showed that downregulation of miR-222 in MCF-7/Adr increased sensitivity to Adr and Adr-induced apoptosis and arrested the cells in G1 phase accompanied by more expressions of p27kip1 especially in nucleus; Taken together the results found that miR-222 induced Adr-resistance at least in part via suppressing p27kip1 expression and altering its subcellular localization and miR-222 inhibitors could reverse Adr-resistance of breast cancer cells;MiR 221 and MiR 222 alterations in sporadic ovarian carcinoma: Relationship to CDKN1B CDKNIC and overall survival; miR-221 and miR-222 negatively regulate expression of CDKN1B p27 and CDKN1C p57 two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas; In contrast CDKN1B expression was not associated with miR-221 or miR-222 expression tumorigenesis;;;;;drug resistance;poor survival cervical and endocervical cancer;glioblastoma;melanoma;ovarian cancer;prostate cancer;breast cancer;ovarian cancer hsa-miR-24-3p CDKN1B 1.55853749533999 0.000524726461381821 -0.759845869565624 0.028743899515939 miRNAWalker2_validate;miRNATAP -0.227681406286786 1.26095324894704e-07 26847530;26044523 The biological significance of miR-24 expression in prostate cancer cells was assessed by a series of in vitro bioassays and the effect on proposed targets p27 CDKN1B and p16 CDK2NA was investigated;With the bioinformatic method we further identified that p27Kip1 is a direct target of miR-24-3p and its protein level was negatively regulated by miR-24-3p ; prostate cancer;breast cancer hsa-miR-421 CDKN1B 1.97624148591545 0.000915838012451138 -0.759845869565624 0.028743899515939 miRanda -0.112669451915086 0.000596982834425083 NA NA NA hsa-miR-455-5p CDKN1B -0.317715589860275 0.616296031007863 -0.759845869565624 0.028743899515939 miRanda;miRNATAP -0.114301116622919 0.000221318473800826 NA NA NA hsa-miR-221-5p CHAD 2.07459535854377 0.0757339015356929 -0.722007033984018 0.548397426269195 MirTarget -0.294389958190889 3.66623010494156e-07 NA NA NA hsa-miR-222-5p CHAD 2.52056758362407 0.00142010793166944 -0.722007033984018 0.548397426269195 MirTarget -0.346641360623711 4.67923019649435e-05 NA NA NA hsa-miR-27a-3p CHRM1 1.76094007417453 0.000216137556256765 -0.175385513466008 0.900947999829478 miRNATAP -0.833436915248404 4.42481543104584e-07 NA NA NA hsa-miR-342-3p CHRM1 1.31107714473009 0.0207211910724662 -0.175385513466008 0.900947999829478 miRanda -0.432031040871023 0.00215029588958016 NA NA NA hsa-let-7d-5p COL1A1 0.831142050231414 0.0126955498524287 -1.84056354039351 0.0428283936196076 miRNATAP -0.736242595043802 2.36678678285063e-06 NA NA NA hsa-let-7f-5p COL1A1 0.971961126099146 0.0240319857511033 -1.84056354039351 0.0428283936196076 miRNATAP -0.330988375714268 0.00619664736510643 NA NA NA hsa-let-7g-5p COL1A1 0.857251702023746 0.00647597344297273 -1.84056354039351 0.0428283936196076 miRNATAP -0.78141081106779 2.40131824211618e-06 NA NA NA hsa-miR-106a-5p COL1A1 3.98693608217557 9.37722470816656e-07 -1.84056354039351 0.0428283936196076 mirMAP -0.270034033004211 1.21948821992489e-05 NA NA NA hsa-miR-106b-5p COL1A1 2.80565545918114 1.14547999022566e-09 -1.84056354039351 0.0428283936196076 mirMAP -0.527805230776855 1.12907897624131e-06 NA NA NA hsa-miR-107 COL1A1 1.49443409571439 0.000130594521065411 -1.84056354039351 0.0428283936196076 PITA;miRanda -0.361912286670645 0.00641596085953541 NA NA NA hsa-miR-17-5p COL1A1 2.3269271449522 2.13987445663942e-05 -1.84056354039351 0.0428283936196076 mirMAP -0.330176665385721 0.00039145185357986 NA NA NA hsa-miR-196a-5p COL1A1 2.71653705877687 0.0233843546205134 -1.84056354039351 0.0428283936196076 miRNATAP -0.140254497250573 0.00102160140385264 NA NA NA hsa-miR-20a-5p COL1A1 2.13553469875764 0.000181201072324354 -1.84056354039351 0.0428283936196076 mirMAP -0.311754473971363 0.000505394044383958 NA NA NA hsa-miR-20b-5p COL1A1 4.5662923200279 4.75238200639144e-05 -1.84056354039351 0.0428283936196076 mirMAP -0.141592361374589 0.00173848234748365 NA NA NA hsa-miR-23a-5p COL1A1 2.86720096840797 0.000290788677230784 -1.84056354039351 0.0428283936196076 mirMAP -0.174097288435129 0.00705242994788015 NA NA NA hsa-miR-29c-3p COL1A1 -0.414153610337085 0.529344128062017 -1.84056354039351 0.0428283936196076 miRNAWalker2_validate;miRTarBase;miRNATAP -0.245497936543541 0.00175768447884849 NA NA NA hsa-miR-30d-3p COL1A1 -0.0740421896025512 0.857423650167556 -1.84056354039351 0.0428283936196076 mirMAP -0.508798584746145 5.5470869958132e-05 NA NA NA hsa-miR-30e-3p COL1A1 -0.0362193022195196 0.932577027239525 -1.84056354039351 0.0428283936196076 mirMAP -0.479293746322041 7.87782827939094e-05 NA NA NA hsa-miR-330-3p COL1A1 2.49094236945806 0.000129367003214715 -1.84056354039351 0.0428283936196076 mirMAP -0.268905839530123 0.000626561404686276 NA NA NA hsa-miR-361-3p COL1A1 0.805698609170807 0.0418491665498322 -1.84056354039351 0.0428283936196076 PITA -0.553999693563706 2.33794100267697e-05 NA NA NA hsa-miR-532-3p COL1A1 0.643755490841218 0.214842585969913 -1.84056354039351 0.0428283936196076 PITA;miRNATAP -0.262844379629406 0.00867649430321237 NA NA NA hsa-miR-590-3p COL1A1 2.35429565068338 2.79601879608564e-06 -1.84056354039351 0.0428283936196076 miRanda -0.371129696394564 0.00024778150914842 NA NA NA hsa-miR-616-5p COL1A1 2.48416313933027 0.00318247475868827 -1.84056354039351 0.0428283936196076 mirMAP;miRNATAP -0.203770345455775 0.00772746556309996 NA NA NA hsa-miR-625-5p COL1A1 2.02792641909347 0.000935142379948297 -1.84056354039351 0.0428283936196076 MirTarget -0.259427071348568 0.00211430009957569 NA NA NA hsa-miR-92a-1-5p COL1A1 2.14839829606717 0.0015466735813532 -1.84056354039351 0.0428283936196076 MirTarget -0.425084123297027 1.03247302673834e-08 NA NA NA hsa-miR-93-5p COL1A1 2.65964181833033 2.58315947526774e-08 -1.84056354039351 0.0428283936196076 mirMAP -0.402728518614805 0.000140978199966934 NA NA NA hsa-let-7d-5p COL1A2 0.831142050231414 0.0126955498524287 -2.4074903809474 0.0132038858386377 MirTarget;miRNATAP -0.811305049738731 1.16473245675138e-06 NA NA NA hsa-let-7f-1-3p COL1A2 1.61507869803314 0.00069342464777815 -2.4074903809474 0.0132038858386377 MirTarget -0.480049449238721 3.40222745923023e-05 NA NA NA hsa-let-7f-5p COL1A2 0.971961126099146 0.0240319857511033 -2.4074903809474 0.0132038858386377 MirTarget;miRNATAP -0.388783382460893 0.00264625141571876 NA NA NA hsa-let-7g-5p COL1A2 0.857251702023746 0.00647597344297273 -2.4074903809474 0.0132038858386377 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.826839279434069 3.19062936758908e-06 NA NA NA hsa-miR-193a-3p COL1A2 0.646392169474854 0.207134343676122 -2.4074903809474 0.0132038858386377 miRanda -0.341368917940043 0.00163594927400134 NA NA NA hsa-miR-196a-5p COL1A2 2.71653705877687 0.0233843546205134 -2.4074903809474 0.0132038858386377 MirTarget;miRNATAP -0.156993010102596 0.00059041327695629 NA NA NA hsa-miR-19a-3p COL1A2 2.17020503944519 0.00122084653711062 -2.4074903809474 0.0132038858386377 MirTarget -0.22504954970786 0.0060052581550391 NA NA NA hsa-miR-19b-3p COL1A2 1.67581705793313 0.000858910586302716 -2.4074903809474 0.0132038858386377 MirTarget -0.417555305209778 0.000132269815918335 NA NA NA hsa-miR-25-3p COL1A2 1.12623030168869 0.00311079344417173 -2.4074903809474 0.0132038858386377 MirTarget;miRNATAP -0.669108328095464 3.97972238969148e-06 NA NA NA hsa-miR-29c-3p COL1A2 -0.414153610337085 0.529344128062017 -2.4074903809474 0.0132038858386377 miRNAWalker2_validate;miRTarBase;miRNATAP -0.253827571070811 0.0025379069504055 NA NA NA hsa-miR-30d-3p COL1A2 -0.0740421896025512 0.857423650167556 -2.4074903809474 0.0132038858386377 MirTarget -0.512349667849357 0.000153814514387612 NA NA NA hsa-miR-30e-3p COL1A2 -0.0362193022195196 0.932577027239525 -2.4074903809474 0.0132038858386377 MirTarget -0.437000646443569 0.000809375601769536 NA NA NA hsa-miR-32-3p COL1A2 2.20477794939766 0.0392771274032852 -2.4074903809474 0.0132038858386377 miRNATAP -0.423477271504932 2.53272017268217e-06 NA NA NA hsa-miR-32-5p COL1A2 2.93035124381469 5.00149131394151e-10 -2.4074903809474 0.0132038858386377 MirTarget;miRNATAP -0.615997519864761 4.73261950924558e-08 NA NA NA hsa-miR-330-5p COL1A2 2.25110496739954 0.000275527655397415 -2.4074903809474 0.0132038858386377 miRanda -0.281370092303073 0.00148399561137761 NA NA NA hsa-miR-33a-3p COL1A2 2.06269680799532 0.00156436055383943 -2.4074903809474 0.0132038858386377 MirTarget -0.326830155888293 0.000104523428736575 NA NA NA hsa-miR-342-3p COL1A2 1.31107714473009 0.0207211910724662 -2.4074903809474 0.0132038858386377 miRanda;miRNATAP -0.301504696149465 0.00198450180149318 NA NA NA hsa-miR-363-3p COL1A2 4.27232887548977 8.53979362839458e-06 -2.4074903809474 0.0132038858386377 MirTarget -0.208073863653219 0.000227929666222705 NA NA NA hsa-miR-590-3p COL1A2 2.35429565068338 2.79601879608564e-06 -2.4074903809474 0.0132038858386377 miRanda -0.396794894969357 0.00025369854986237 NA NA NA hsa-miR-7-5p COL1A2 3.59831747997243 0.000676336260217879 -2.4074903809474 0.0132038858386377 miRNATAP -0.202706097797999 0.00147098697303035 NA NA NA hsa-miR-92a-3p COL1A2 1.87892405805529 1.27013821556583e-05 -2.4074903809474 0.0132038858386377 MirTarget;miRNATAP -0.591859006461079 2.95063044958949e-06 NA NA NA hsa-miR-92b-3p COL1A2 1.69303761469782 0.0103484911955574 -2.4074903809474 0.0132038858386377 MirTarget;miRNATAP -0.280225522418452 0.000764612270543414 NA NA NA hsa-miR-200c-5p COL2A1 5.34093243595571 3.35355119348069e-10 -1.25746345332333 0.447107038374148 miRNATAP -0.383041871708049 0.00345706626368284 NA NA NA hsa-miR-29a-3p COL2A1 -0.638239697975974 0.251923581881716 -1.25746345332333 0.447107038374148 MirTarget;miRNATAP -0.620359392419201 0.000227456324965556 NA NA NA hsa-miR-29b-3p COL2A1 0.666547117072858 0.234055379278093 -1.25746345332333 0.447107038374148 MirTarget;miRNATAP -0.614294687220086 0.000241833510182875 NA NA NA hsa-miR-29c-3p COL2A1 -0.414153610337085 0.529344128062017 -1.25746345332333 0.447107038374148 MirTarget;miRNATAP -0.606779828626813 1.80587041193258e-05 NA NA NA hsa-let-7a-5p COL4A1 0.148081801547773 0.645305441523746 -1.16864065099484 0.0984791802100705 TargetScan;miRNATAP -0.395216601708053 0.00200095586375547 NA NA NA hsa-let-7b-3p COL4A1 0.589364128513318 0.200507534602851 -1.16864065099484 0.0984791802100705 miRNATAP -0.323866459414722 0.000215138506878023 NA NA NA hsa-let-7b-5p COL4A1 -0.189422992330471 0.651878220048983 -1.16864065099484 0.0984791802100705 miRNATAP -0.376516880807364 9.17121881705376e-05 NA NA NA hsa-let-7g-5p COL4A1 0.857251702023746 0.00647597344297273 -1.16864065099484 0.0984791802100705 miRNATAP -0.521878665910767 5.47715731470755e-05 NA NA NA hsa-miR-16-5p COL4A1 2.93575808220754 2.15436817162977e-10 -1.16864065099484 0.0984791802100705 miRNAWalker2_validate -0.337832000672797 6.10778641796011e-05 NA NA NA hsa-miR-29c-3p COL4A1 -0.414153610337085 0.529344128062017 -1.16864065099484 0.0984791802100705 miRNAWalker2_validate;miRTarBase;miRNATAP -0.337967010855051 1.68085879155805e-08 NA NA NA hsa-miR-3065-5p COL4A1 2.14185373842821 0.0609400502269891 -1.16864065099484 0.0984791802100705 miRNATAP -0.147266374061876 0.000705791993274342 NA NA NA hsa-miR-362-3p COL4A1 0.679952485897744 0.226148468488576 -1.16864065099484 0.0984791802100705 miRanda -0.251903181276386 0.000441751885714519 NA NA NA hsa-miR-429 COL4A1 6.39965293994036 1.96920201593608e-18 -1.16864065099484 0.0984791802100705 miRanda;miRNATAP -0.247799101573786 1.22789780513352e-06 NA NA NA hsa-miR-590-3p COL4A1 2.35429565068338 2.79601879608564e-06 -1.16864065099484 0.0984791802100705 miRanda -0.222848822908421 0.00481327470873168 NA NA NA hsa-miR-99a-5p COL4A1 -2.72139054000803 0.00621971944534118 -1.16864065099484 0.0984791802100705 miRNAWalker2_validate -0.160770833475788 5.25644974578457e-05 NA NA NA hsa-let-7a-5p COL4A2 0.148081801547773 0.645305441523746 -1.9722594684363 0.00704429653435828 TargetScan;miRNATAP -0.368446948360621 0.0056180383454478 NA NA NA hsa-let-7b-5p COL4A2 -0.189422992330471 0.651878220048983 -1.9722594684363 0.00704429653435828 miRNATAP -0.320323636043953 0.00141991339139528 NA NA NA hsa-let-7g-5p COL4A2 0.857251702023746 0.00647597344297273 -1.9722594684363 0.00704429653435828 miRNATAP -0.49045124827628 0.000271321261445424 NA NA NA hsa-miR-155-5p COL4A2 2.81443182173772 7.42530504828797e-05 -1.9722594684363 0.00704429653435828 miRNAWalker2_validate -0.174348665871742 0.00262996500334362 NA NA NA hsa-miR-16-5p COL4A2 2.93575808220754 2.15436817162977e-10 -1.9722594684363 0.00704429653435828 miRNAWalker2_validate -0.365920993931199 2.85031407247609e-05 NA NA NA hsa-miR-29c-3p COL4A2 -0.414153610337085 0.529344128062017 -1.9722594684363 0.00704429653435828 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.316970244389103 3.99064158591322e-07 NA NA NA hsa-miR-9-5p COL4A2 1.79620806707734 0.14526963042518 -1.9722594684363 0.00704429653435828 MirTarget;miRNATAP -0.101015090031277 0.00265111086723359 NA NA NA hsa-miR-429 COL4A3 6.39965293994036 1.96920201593608e-18 -0.962457819759664 0.474906169860219 miRanda;miRNATAP -0.280083688503402 0.00443179771736869 NA NA NA hsa-miR-501-3p COL4A3 1.72239979688923 0.0075900263732748 -0.962457819759664 0.474906169860219 miRNATAP -0.326405699251568 0.00567956439062536 NA NA NA hsa-miR-502-3p COL4A3 -0.102232623565007 0.80889202592629 -0.962457819759664 0.474906169860219 miRNATAP -0.52717966224417 0.0039577808353146 NA NA NA hsa-miR-944 COL4A3 7.20925181386398 0.000823207457340648 -0.962457819759664 0.474906169860219 mirMAP -0.1146419186109 0.0086105380823224 NA NA NA hsa-miR-130b-3p COL4A4 3.9204771543282 1.2714917955808e-11 -1.65374511108892 0.179964589487978 mirMAP -0.307008627090268 0.0087655565122188 NA NA NA hsa-miR-203a-3p COL4A4 6.35084246337388 7.89944323347948e-08 -1.65374511108892 0.179964589487978 MirTarget -0.180088252251077 0.00176197471535859 NA NA NA hsa-miR-224-3p COL4A4 2.84876340814503 0.000179138399939161 -1.65374511108892 0.179964589487978 mirMAP -0.250172482769664 0.00644300556624605 NA NA NA hsa-miR-429 COL4A4 6.39965293994036 1.96920201593608e-18 -1.65374511108892 0.179964589487978 miRNATAP -0.323444866263489 0.000318526238217666 NA NA NA hsa-miR-532-3p COL4A4 0.643755490841218 0.214842585969913 -1.65374511108892 0.179964589487978 miRNATAP -0.357966561962891 0.00834663545682688 NA NA NA hsa-miR-9-3p COL4A4 1.69328215716742 0.125170982657059 -1.65374511108892 0.179964589487978 mirMAP -0.265019719734635 3.1456409779024e-05 NA NA NA hsa-miR-944 COL4A4 7.20925181386398 0.000823207457340648 -1.65374511108892 0.179964589487978 PITA;mirMAP;miRNATAP -0.127276902883983 0.00141845249313779 NA NA NA hsa-let-7g-5p COL4A5 0.857251702023746 0.00647597344297273 -1.67964584353761 0.225288027405651 miRNATAP -0.893679157739031 0.00043743689406293 NA NA NA hsa-miR-429 COL4A5 6.39965293994036 1.96920201593608e-18 -1.67964584353761 0.225288027405651 miRanda -0.479325081479026 1.6751138465762e-06 NA NA NA hsa-miR-429 COL4A6 6.39965293994036 1.96920201593608e-18 -5.12242732011008 0.00453294903972349 miRanda;miRNATAP -0.715157344900154 4.10833871715696e-08 NA NA NA hsa-miR-130a-5p COL6A3 1.58028512890005 0.024346333013728 -3.07518364362208 0.000679056442919429 miRNATAP -0.25053945495258 0.000793393076413353 NA NA NA hsa-miR-362-3p COL6A3 0.679952485897744 0.226148468488576 -3.07518364362208 0.000679056442919429 miRanda -0.312148326753103 0.000740193451939931 NA NA NA hsa-miR-429 COL6A3 6.39965293994036 1.96920201593608e-18 -3.07518364362208 0.000679056442919429 miRNATAP -0.331218235808428 4.74841912512098e-07 NA NA NA hsa-miR-590-3p COL6A3 2.35429565068338 2.79601879608564e-06 -3.07518364362208 0.000679056442919429 miRanda -0.393167889977125 0.00010451248703474 NA NA NA hsa-miR-335-5p COL6A6 0.167216045757305 0.803897055331049 -3.77371640822407 0.00327823805709259 miRNAWalker2_validate -0.285880995209097 0.00875599169064991 NA NA NA hsa-miR-375 COL6A6 3.3784490463318 0.0449946294355695 -3.77371640822407 0.00327823805709259 miRanda -0.116890174877169 0.00677287743553438 NA NA NA hsa-miR-429 COL6A6 6.39965293994036 1.96920201593608e-18 -3.77371640822407 0.00327823805709259 miRanda -0.359484135009101 0.000128848943923457 NA NA NA hsa-miR-501-5p COL6A6 1.0411896821345 0.0777206709183552 -3.77371640822407 0.00327823805709259 mirMAP -0.405205892566032 0.00108413331234046 NA NA NA hsa-miR-532-3p COL6A6 0.643755490841218 0.214842585969913 -3.77371640822407 0.00327823805709259 MirTarget -0.596722367241998 2.23856843954461e-05 NA NA NA hsa-miR-590-5p COL6A6 1.51400888103768 0.0023888567923017 -3.77371640822407 0.00327823805709259 miRanda -0.53458648169123 0.000258374685425615 NA NA NA hsa-miR-616-5p COL6A6 2.48416313933027 0.00318247475868827 -3.77371640822407 0.00327823805709259 mirMAP -0.329370273501728 0.00235338947496993 NA NA NA hsa-let-7b-3p COL9A1 0.589364128513318 0.200507534602851 -1.52185565754638 0.254890863627213 mirMAP -0.444581928580368 0.00749011365316275 NA NA NA hsa-let-7f-1-3p COL9A1 1.61507869803314 0.00069342464777815 -1.52185565754638 0.254890863627213 mirMAP -0.649095978917091 4.38726764828042e-05 NA NA NA hsa-miR-944 COL9A1 7.20925181386398 0.000823207457340648 -1.52185565754638 0.254890863627213 mirMAP -0.27161158761151 1.15010631768292e-10 NA NA NA hsa-miR-342-5p CREB3L1 1.3865615438184 0.0153598969109545 -2.26613571321427 0.0937634013147299 MirTarget -0.413378046768015 0.00204751660586268 NA NA NA hsa-miR-34c-5p CREB3L1 2.64675661251039 0.0157394735757952 -2.26613571321427 0.0937634013147299 miRanda;miRNATAP -0.222465476242483 0.00138313623436409 NA NA NA hsa-let-7d-5p CREB3L2 0.831142050231414 0.0126955498524287 -2.05047848200983 0.000753835551731792 mirMAP -0.352032076001589 0.000891146567560531 NA NA NA hsa-miR-1271-5p CREB3L2 0.212382644103427 0.742544160267329 -2.05047848200983 0.000753835551731792 MirTarget -0.154320198613702 0.00424207716491107 NA NA NA hsa-miR-16-2-3p CREB3L2 3.79845098071094 1.49120139344659e-13 -2.05047848200983 0.000753835551731792 mirMAP -0.225311371734651 0.0005198971394658 NA NA NA hsa-miR-18a-3p CREB3L2 3.64944956993027 7.20156641833731e-07 -2.05047848200983 0.000753835551731792 MirTarget -0.131539490015369 0.00476452370934671 NA NA NA hsa-miR-1976 CREB3L2 3.27217274919653 3.16337235854532e-12 -2.05047848200983 0.000753835551731792 MirTarget -0.248635825741654 0.000516340845715992 NA NA NA hsa-miR-24-3p CREB3L2 1.55853749533999 0.000524726461381821 -2.05047848200983 0.000753835551731792 miRNATAP -0.283635612566952 0.000232320211995846 NA NA NA hsa-miR-25-3p CREB3L2 1.12623030168869 0.00311079344417173 -2.05047848200983 0.000753835551731792 MirTarget;miRNATAP -0.279908009628931 0.00236012876312251 NA NA NA hsa-miR-330-3p CREB3L2 2.49094236945806 0.000129367003214715 -2.05047848200983 0.000753835551731792 mirMAP -0.181528242543702 0.00060191634617276 NA NA NA hsa-miR-33a-3p CREB3L2 2.06269680799532 0.00156436055383943 -2.05047848200983 0.000753835551731792 mirMAP -0.178885339154335 0.000754047848839223 NA NA NA hsa-miR-9-3p CREB3L2 1.69328215716742 0.125170982657059 -2.05047848200983 0.000753835551731792 mirMAP -0.142476809389952 6.24953985775576e-06 NA NA NA hsa-miR-9-5p CREB3L2 1.79620806707734 0.14526963042518 -2.05047848200983 0.000753835551731792 miRNATAP -0.134942425847874 1.10015144346381e-06 NA NA NA hsa-miR-92a-1-5p CREB3L2 2.14839829606717 0.0015466735813532 -2.05047848200983 0.000753835551731792 MirTarget -0.25996340847929 2.24190587227833e-07 NA NA NA hsa-miR-92a-3p CREB3L2 1.87892405805529 1.27013821556583e-05 -2.05047848200983 0.000753835551731792 miRNAWalker2_validate;MirTarget;miRNATAP -0.340870759197703 1.9423340449263e-05 NA NA NA hsa-miR-944 CREB3L2 7.20925181386398 0.000823207457340648 -2.05047848200983 0.000753835551731792 mirMAP -0.127772511265464 3.40168540068821e-11 NA NA NA hsa-miR-142-3p CREB5 4.35304505457969 3.10014573651358e-10 -1.55239548108621 0.139690196073183 miRNATAP -0.31504029576671 0.00015422406859507 NA NA NA hsa-miR-142-5p CREB5 3.95552531913424 1.49536283724079e-08 -1.55239548108621 0.139690196073183 mirMAP -0.308352180902829 0.000201127980894061 NA NA NA hsa-miR-330-3p CREB5 2.49094236945806 0.000129367003214715 -1.55239548108621 0.139690196073183 MirTarget;mirMAP -0.274505342725045 0.00256125368476991 NA NA NA hsa-miR-106a-5p CSF1 3.98693608217557 9.37722470816656e-07 -1.10144752456835 0.127316209883384 miRNATAP -0.207093141183936 2.40233734816335e-05 NA NA NA hsa-miR-106b-5p CSF1 2.80565545918114 1.14547999022566e-09 -1.10144752456835 0.127316209883384 miRNATAP -0.25632446917411 0.00324390838466919 NA NA NA hsa-miR-128-3p CSF1 1.36248409467631 0.00408435995818078 -1.10144752456835 0.127316209883384 MirTarget -0.264511355616602 0.00221992818576221 22909061 By mutations in putative miRNA targets in CSF-1 mRNA 3'UTR we identified a common target for both miR-128 and miR-152; We have also found that both miR-128 and miR-152 down-regulate CSF-1 mRNA and protein expression in ovarian cancer cells leading to decreased cell motility and adhesion in vitro two major aspects of the metastatic potential of cancer cells; Our results provide the evidence for a mechanism by which miR-128 and miR-152 down-regulate CSF-1 an important regulator of ovarian cancer motility ovarian cancer hsa-miR-130b-3p CSF1 3.9204771543282 1.2714917955808e-11 -1.10144752456835 0.127316209883384 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.28490712111123 2.77815654229906e-05 22005523 CSF-1 regulated by miR-130b was detected using Dual Luciferase Reporter system; CSF-1 expression was negatively associated with miR-130b level in ovarian tissues and cell lines; Luciferase assay validated CSF-1 is a direct target of miR-130b; Knock-down of CSF-1 sensitized ovarian cancer cells to anticancer drugs and could partially attenuate the resistance inducing effect of miR-130b inhibitors; Downregulation of miR-130b promotes the development of multidrug resistant ovarian cancer partially by targeting the 3'-UTR of CSF-1 and the silencing of miR-130b may be mediated by DNA methylation drug resistance ovarian cancer hsa-miR-20b-5p CSF1 4.5662923200279 4.75238200639144e-05 -1.10144752456835 0.127316209883384 miRNATAP -0.125907566733056 0.000436020138970852 NA NA NA hsa-miR-429 CSF1 6.39965293994036 1.96920201593608e-18 -1.10144752456835 0.127316209883384 PITA;miRanda;miRNATAP -0.267688495209562 2.68077166869098e-07 NA NA NA hsa-miR-532-3p CSF1 0.643755490841218 0.214842585969913 -1.10144752456835 0.127316209883384 MirTarget;PITA -0.320428219461936 4.8152066776354e-05 NA NA NA hsa-miR-532-5p CSF1 -0.297424983759107 0.503934707453099 -1.10144752456835 0.127316209883384 miRNATAP -0.333335779452154 0.000322978882604913 NA NA NA hsa-miR-93-5p CSF1 2.65964181833033 2.58315947526774e-08 -1.10144752456835 0.127316209883384 miRNATAP -0.335436339134181 6.30647587646198e-05 NA NA NA hsa-miR-940 CSF1 3.78496690968119 4.75227557809023e-05 -1.10144752456835 0.127316209883384 MirTarget;PITA;miRNATAP -0.176285220256753 0.000900997741448821 NA NA NA hsa-miR-96-5p CSF1 5.62521466029286 1.54938806718028e-10 -1.10144752456835 0.127316209883384 miRNATAP -0.281806310836912 2.30192441736421e-07 NA NA NA hsa-miR-339-5p CSF1R 1.23326828594484 0.0307501214818698 -0.256118710802276 0.75620685910503 miRanda -0.213453761217853 0.00923606349236472 NA NA NA hsa-miR-30b-3p CSF3R 0.169674321578618 0.766080356926625 0.315128639356519 0.723537108755114 MirTarget -0.249262137728515 0.00527678366341842 NA NA NA hsa-miR-361-5p CSF3R 0.00649167180664723 0.985202350239079 0.315128639356519 0.723537108755114 miRanda -0.605979218340613 3.40398030804743e-05 NA NA NA hsa-miR-429 CSF3R 6.39965293994036 1.96920201593608e-18 0.315128639356519 0.723537108755114 miRanda -0.202612358524427 0.00181334813811197 NA NA NA hsa-miR-101-3p DDIT4 -1.12421603598195 0.0200907284788457 0.477804731551061 0.499952560954147 miRNAWalker2_validate;MirTarget;miRNATAP -0.230006612065332 0.00577054837814306 NA NA NA hsa-miR-200b-3p DDIT4 5.56167217794639 6.43540045061709e-16 0.477804731551061 0.499952560954147 TargetScan -0.146171543167626 0.00840500015299485 NA NA NA hsa-miR-199a-5p EFNA1 -1.24888110793613 0.0747755616523728 1.38418405002605 0.0151769179519757 miRanda -0.137187927637542 0.00294841533019336 NA NA NA hsa-miR-218-5p EFNA1 -1.62589026509455 0.0400573414088521 1.38418405002605 0.0151769179519757 miRNAWalker2_validate -0.262411995383265 3.50372638680852e-11 NA NA NA hsa-miR-30c-2-3p EFNA1 -0.916427677918778 0.300195789569016 1.38418405002605 0.0151769179519757 MirTarget -0.105121340945507 0.00402901683123548 NA NA NA hsa-miR-324-3p EFNA1 1.51345381556672 0.0038447546677657 1.38418405002605 0.0151769179519757 MirTarget;miRNATAP -0.198202380196752 0.00132997727090526 NA NA NA hsa-miR-205-5p EFNA2 8.08298115900323 3.83045179398654e-07 1.82410340111827 0.171498237373106 MirTarget -0.277763332758965 8.81584402759741e-10 NA NA NA hsa-miR-30a-5p EFNA3 -0.768430903969183 0.320487552854215 2.44414586710552 0.00286053689177754 MirTarget;mirMAP;miRNATAP -0.286925165593985 1.51804789970605e-06 NA NA NA hsa-miR-361-3p EFNA3 0.805698609170807 0.0418491665498322 2.44414586710552 0.00286053689177754 MirTarget;miRNATAP -0.419709587332002 0.000423973904628832 NA NA NA hsa-miR-362-3p EFNA5 0.679952485897744 0.226148468488576 1.94534276433787 0.0330650384938423 miRanda -0.256344729328933 0.00587619045180783 NA NA NA hsa-miR-421 EFNA5 1.97624148591545 0.000915838012451138 1.94534276433787 0.0330650384938423 mirMAP -0.256577038443191 0.00313076844591078 NA NA NA hsa-miR-125a-5p EGFR -1.32352790615388 0.00714301627309467 1.4001245301835 0.170261817468909 mirMAP -0.42322860924045 0.000316823060379402 19881956;27094723;24484870 We report that EGFR signaling leads to transcriptional repression of the miRNA miR-125a through the ETS family transcription factor PEA3;Suppression of microRNA 125a 5p upregulates the TAZ EGFR signaling pathway and promotes retinoblastoma proliferation; Moreover the overexpression of miR-125a-5p led to a decrease in TAZ expression and downstream EGFR signaling pathway activation both in vitro and vivo; Finally TAZ overexpression in retinoblastoma cells overexpressing miR-125a-5p restored retinoblastoma cell proliferation and EGFR pathway activation; Taken together our data demonstrated that miR-125a-5p functions as an important tumor suppressor that suppresses the EGFR pathway by targeting TAZ to inhibit tumor progression in retinoblastoma;miR 125a regulates cell cycle proliferation and apoptosis by targeting the ErbB pathway in acute myeloid leukemia; Profiling revealed the ErbB pathway as significantly decreased with ectopic miR-125a; Either ectopic expression of miR-125a or inhibition of ErbB via Mubritinib resulted in inhibition of cell cycle proliferation and progression with enhanced apoptosis revealing ErbB inhibitors as potential novel therapeutic agents for treating miR-125a-low AML ;progression;progression ovarian cancer;retinoblastoma;acute myeloid leukemia hsa-miR-128-3p EGFR 1.36248409467631 0.00408435995818078 1.4001245301835 0.170261817468909 miRNAWalker2_validate;miRTarBase -0.325270996219395 0.00791157440942446 NA NA NA hsa-miR-148b-5p EGFR 2.80812018666078 3.97536665756679e-08 1.4001245301835 0.170261817468909 mirMAP -0.287810299143976 0.00993634422968525 NA NA NA hsa-miR-186-5p EGFR 0.445443449112564 0.185447310527704 1.4001245301835 0.170261817468909 mirMAP -0.72926872723882 2.99701181181913e-05 NA NA NA hsa-miR-188-5p EGFR 1.39111178824125 0.0251592818948912 1.4001245301835 0.170261817468909 mirMAP -0.263000006285575 0.00496388298567065 NA NA NA hsa-miR-192-3p EGFR 0.84572845432662 0.480940346018965 1.4001245301835 0.170261817468909 mirMAP -0.19627166733635 5.85182501324464e-05 NA NA NA hsa-miR-192-5p EGFR 1.77716187978541 0.113485496183047 1.4001245301835 0.170261817468909 mirMAP -0.254778390974915 4.87299611634051e-07 NA NA NA hsa-miR-194-3p EGFR 1.91743783341496 0.105383373371284 1.4001245301835 0.170261817468909 MirTarget -0.18150332146796 0.000207666578228104 NA NA NA hsa-miR-200a-3p EGFR 6.336081120041 4.024313571871e-16 1.4001245301835 0.170261817468909 MirTarget -0.314197934364205 6.96888933660157e-06 26184032;19671845 MicroRNA 200a Targets EGFR and c Met to Inhibit Migration Invasion and Gefitinib Resistance in Non Small Cell Lung Cancer; In this study we found that miR-200a is downregulated in NSCLC cells where it directly targets the 3'-UTR of both EGFR and c-Met mRNA; Overexpression of miR-200a in NSCLC cells significantly downregulates both EGFR and c-Met levels and severely inhibits cell migration and invasion;Protein expression and signaling pathway modulation as well as intracellular distribution of EGFR and ERRFI-1 were validated through Western blot analysis and confocal microscopy whereas ERRFI-1 direct target of miR-200 members was validated by using the wild-type and mutant 3'-untranslated region/ERRFI-1/luciferse reporters; We identified a tight association between the expression of miRNAs of the miR-200 family epithelial phenotype and sensitivity to EGFR inhibitors-induced growth inhibition in bladder carcinoma cell lines; The changes in EGFR sensitivity by silencing or forced expression of ERRFI-1 or by miR-200 expression have also been validated in additional cell lines UMUC5 and T24; Members of the miR-200 family appear to control the EMT process and sensitivity to EGFR therapy in bladder cancer cells and the expression of miR-200 is sufficient to restore EGFR dependency at least in some of the mesenchymal bladder cancer cells drug resistance;cell migration; lung squamous cell cancer;bladder cancer hsa-miR-26b-3p EGFR 0.985177548213122 0.0351427970185971 1.4001245301835 0.170261817468909 mirMAP -0.334456182236821 0.00731279830838523 NA NA NA hsa-miR-29b-2-5p EGFR -0.596051745078872 0.189540844841389 1.4001245301835 0.170261817468909 mirMAP -0.650549075574319 2.87046383123889e-07 NA NA NA hsa-miR-30a-3p EGFR -1.22212086897848 0.167565797592104 1.4001245301835 0.170261817468909 mirMAP -0.214317153681821 0.000993490591329179 NA NA NA hsa-miR-30a-5p EGFR -0.768430903969183 0.320487552854215 1.4001245301835 0.170261817468909 miRNAWalker2_validate -0.276326861755088 0.000207968085523555 NA NA NA hsa-miR-362-5p EGFR -1.22309034685697 0.0452665543907975 1.4001245301835 0.170261817468909 mirMAP -0.429041522813014 4.85211172370353e-06 NA NA NA hsa-miR-375 EGFR 3.3784490463318 0.0449946294355695 1.4001245301835 0.170261817468909 miRanda -0.222319476304576 1.9252452765405e-11 NA NA NA hsa-miR-7-1-3p EGFR 1.43074343339835 0.00471215970502094 1.4001245301835 0.170261817468909 mirMAP -0.478554115110538 2.53296595691169e-05 NA NA NA hsa-miR-30c-5p EIF4E 0.38723991118075 0.348605235643473 -0.0359303778580173 0.911924839444555 mirMAP -0.125333066167818 0.00521766492206099 NA NA NA hsa-miR-125a-5p EIF4EBP1 -1.32352790615388 0.00714301627309467 1.77505739780472 0.000576225625234467 miRNAWalker2_validate;MirTarget;miRanda;miRNATAP -0.187207630601775 0.00176831220073964 26646586 Increased expression of miR-125a and miR-125b inhibited invasion and migration of SKOV3 and OVCAR-429 ovarian cancer cells and was associated with a decrease in EIF4EBP1 expression ovarian cancer hsa-miR-125a-5p EPHA2 -1.32352790615388 0.00714301627309467 1.48041900184878 0.0510045839308021 miRanda -0.326085477384433 0.000189094544089372 NA NA NA hsa-miR-30c-2-3p EPHA2 -0.916427677918778 0.300195789569016 1.48041900184878 0.0510045839308021 MirTarget -0.141706376294899 0.00354610646606723 NA NA NA hsa-miR-16-2-3p F2R 3.79845098071094 1.49120139344659e-13 -1.46837393535998 0.0314567759787357 mirMAP -0.387009718156311 6.06660915049893e-08 NA NA NA hsa-miR-429 F2R 6.39965293994036 1.96920201593608e-18 -1.46837393535998 0.0314567759787357 miRanda -0.269043068916289 4.29250868598432e-08 NA NA NA hsa-miR-590-3p F2R 2.35429565068338 2.79601879608564e-06 -1.46837393535998 0.0314567759787357 miRanda;mirMAP;miRNATAP -0.206908522172375 0.0067860272199536 NA NA NA hsa-miR-590-5p F2R 1.51400888103768 0.0023888567923017 -1.46837393535998 0.0314567759787357 miRanda -0.242094988175131 0.00183664431285881 NA NA NA hsa-miR-199a-5p FASLG -1.24888110793613 0.0747755616523728 1.92790162472903 0.0908475849274605 miRanda -0.398497989415625 1.31601874419318e-05 NA NA NA hsa-miR-28-5p FASLG -0.815636722979196 0.0221199948901761 1.92790162472903 0.0908475849274605 miRanda -0.57816364875664 0.00170836414115334 NA NA NA hsa-miR-324-5p FASLG 1.31253452379847 0.0116806680545163 1.92790162472903 0.0908475849274605 miRanda -0.332106354222357 0.00772738622468345 NA NA NA hsa-miR-92b-3p FASLG 1.69303761469782 0.0103484911955574 1.92790162472903 0.0908475849274605 miRNATAP -0.252529060131383 0.00986337973635399 NA NA NA hsa-miR-186-5p FGF1 0.445443449112564 0.185447310527704 -0.904800782358151 0.37514033641596 mirMAP -0.498564513948469 0.00456225800988677 NA NA NA hsa-miR-18a-5p FGF1 3.90770175770219 9.15298615034137e-10 -0.904800782358151 0.37514033641596 MirTarget -0.41163099594303 2.32644463832958e-06 NA NA NA hsa-miR-330-5p FGF1 2.25110496739954 0.000275527655397415 -0.904800782358151 0.37514033641596 miRanda;miRNATAP -0.300815609641433 0.00115338039105615 NA NA NA hsa-miR-429 FGF1 6.39965293994036 1.96920201593608e-18 -0.904800782358151 0.37514033641596 miRNATAP -0.277552339482351 0.000183037961286987 NA NA NA hsa-miR-484 FGF1 1.79050445056016 0.000217287101253701 -0.904800782358151 0.37514033641596 MirTarget;PITA;miRNATAP -0.634998887940648 5.85563813084433e-08 NA NA NA hsa-miR-532-3p FGF1 0.643755490841218 0.214842585969913 -0.904800782358151 0.37514033641596 miRNATAP -0.387150102032302 0.000527239876040661 NA NA NA hsa-miR-550a-5p FGF1 1.21781238856895 0.0613791144699551 -0.904800782358151 0.37514033641596 MirTarget -0.314103791160951 0.000393501674872474 NA NA NA hsa-miR-576-5p FGF1 1.30320223793746 0.00648929463912994 -0.904800782358151 0.37514033641596 PITA;mirMAP -0.327654055057913 0.00686443176136871 NA NA NA hsa-miR-590-5p FGF1 1.51400888103768 0.0023888567923017 -0.904800782358151 0.37514033641596 MirTarget;miRanda;miRNATAP -0.451620799574134 9.03523892284351e-05 NA NA NA hsa-miR-7-5p FGF1 3.59831747997243 0.000676336260217879 -0.904800782358151 0.37514033641596 miRNAWalker2_validate -0.227873135380002 0.000618398446708633 NA NA NA hsa-miR-10a-5p FGF11 -0.482300926520507 0.594608783320466 2.65301970671851 0.01261631469404 mirMAP -0.540123135463698 1.55078597656375e-17 NA NA NA hsa-miR-125a-5p FGF11 -1.32352790615388 0.00714301627309467 2.65301970671851 0.01261631469404 mirMAP -0.494060493961994 5.53596234226275e-05 NA NA NA hsa-miR-181c-5p FGF11 -0.302833440762172 0.537532549455539 2.65301970671851 0.01261631469404 mirMAP -0.333056312006498 0.00740153110235258 NA NA NA hsa-miR-199b-5p FGF11 -0.53728867775768 0.476885702455766 2.65301970671851 0.01261631469404 miRanda -0.226650311361356 0.00470364083999176 NA NA NA hsa-miR-28-5p FGF11 -0.815636722979196 0.0221199948901761 2.65301970671851 0.01261631469404 miRanda -0.597544575266832 0.000516029122759738 NA NA NA hsa-miR-335-5p FGF11 0.167216045757305 0.803897055331049 2.65301970671851 0.01261631469404 miRNAWalker2_validate;mirMAP -0.260708948424566 0.00379785190176695 NA NA NA hsa-miR-497-5p FGF11 -1.44150596209372 0.0225146607606395 2.65301970671851 0.01261631469404 mirMAP -0.379969738273999 6.46836099013065e-05 NA NA NA hsa-miR-532-3p FGF11 0.643755490841218 0.214842585969913 2.65301970671851 0.01261631469404 mirMAP -0.385940981743513 0.000977436732392584 NA NA NA hsa-miR-628-5p FGF11 1.04832355434705 0.0252368809675445 2.65301970671851 0.01261631469404 miRNATAP -0.392245033809592 0.00256535435087641 NA NA NA hsa-miR-142-5p FGF12 3.95552531913424 1.49536283724079e-08 -1.91394425895923 0.179665722286034 miRNATAP -0.299864470156096 0.00806374214219134 NA NA NA hsa-let-7b-3p FGF13 0.589364128513318 0.200507534602851 -4.85110267282668 1.82792041988563e-05 MirTarget;miRNATAP -0.380628231137145 0.00766409451664036 NA NA NA hsa-let-7f-1-3p FGF13 1.61507869803314 0.00069342464777815 -4.85110267282668 1.82792041988563e-05 MirTarget -0.586771661494691 1.64308196990907e-05 NA NA NA hsa-let-7f-2-3p FGF13 1.02768112108475 0.0787293499732611 -4.85110267282668 1.82792041988563e-05 MirTarget -0.357864947660702 0.00170173798430677 NA NA NA hsa-miR-141-3p FGF13 7.30474126597325 1.45115996357606e-24 -4.85110267282668 1.82792041988563e-05 TargetScan -0.376818681678676 5.94850485316558e-06 NA NA NA hsa-miR-142-5p FGF13 3.95552531913424 1.49536283724079e-08 -4.85110267282668 1.82792041988563e-05 PITA -0.371402228501292 3.90137579370002e-05 NA NA NA hsa-miR-200b-5p FGF13 6.81954246537908 6.31100593281326e-24 -4.85110267282668 1.82792041988563e-05 MirTarget -0.234643072355969 0.00846026232590831 NA NA NA hsa-miR-31-3p FGF13 5.7035081317825 2.15133648211091e-05 -4.85110267282668 1.82792041988563e-05 miRNATAP -0.423831416686979 5.37391529451371e-14 NA NA NA hsa-miR-362-3p FGF14 0.679952485897744 0.226148468488576 -3.2666985595731 0.00752892580587762 miRanda -0.453984416438245 0.000261413163907632 NA NA NA hsa-miR-421 FGF14 1.97624148591545 0.000915838012451138 -3.2666985595731 0.00752892580587762 miRanda -0.301541825920592 0.00981713310422506 NA NA NA hsa-miR-590-3p FGF14 2.35429565068338 2.79601879608564e-06 -3.2666985595731 0.00752892580587762 miRanda -0.538450638704515 7.86697187153333e-05 NA NA NA hsa-miR-15a-5p FGF18 2.0535411006904 1.91108976398046e-06 -3.01542595781322 0.0221151767151304 miRNATAP -0.460384004560966 0.00775915889139791 NA NA NA hsa-miR-16-5p FGF18 2.93575808220754 2.15436817162977e-10 -3.01542595781322 0.0221151767151304 miRNATAP -0.606136012766895 0.000120603503065243 NA NA NA hsa-miR-21-5p FGF18 2.65163477806992 6.72089787690756e-16 -3.01542595781322 0.0221151767151304 miRNATAP -0.796731311488867 0.000310248371727273 NA NA NA hsa-miR-330-5p FGF18 2.25110496739954 0.000275527655397415 -3.01542595781322 0.0221151767151304 PITA;miRanda;miRNATAP -0.705698029841673 1.94542850283262e-09 NA NA NA hsa-miR-15a-5p FGF2 2.0535411006904 1.91108976398046e-06 -4.7426237294682 2.88390048531716e-06 MirTarget;miRNATAP -0.544091858031343 4.73995293778273e-05 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-1-3p FGF2 2.83281226969693 7.54359864580834e-09 -4.7426237294682 2.88390048531716e-06 mirMAP -0.519661346969457 7.25223541348293e-06 NA NA NA hsa-miR-16-2-3p FGF2 3.79845098071094 1.49120139344659e-13 -4.7426237294682 2.88390048531716e-06 mirMAP -0.459075147077176 2.39530412317278e-05 NA NA NA hsa-miR-16-5p FGF2 2.93575808220754 2.15436817162977e-10 -4.7426237294682 2.88390048531716e-06 miRNAWalker2_validate;MirTarget;miRNATAP -0.382491794884229 0.00193553698923076 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-19b-1-5p FGF2 1.51335451095424 0.0014717605268143 -4.7426237294682 2.88390048531716e-06 mirMAP -0.48434219021616 7.33107402348553e-05 NA NA NA hsa-miR-200b-3p FGF2 5.56167217794639 6.43540045061709e-16 -4.7426237294682 2.88390048531716e-06 mirMAP -0.509650803431375 8.73024781893149e-11 NA NA NA hsa-miR-200c-3p FGF2 6.47012025883743 2.64500707716408e-26 -4.7426237294682 2.88390048531716e-06 mirMAP -0.509145367686688 3.3797939749436e-09 NA NA NA hsa-miR-21-5p FGF2 2.65163477806992 6.72089787690756e-16 -4.7426237294682 2.88390048531716e-06 mirMAP -0.567342076857507 0.00100450723749317 NA NA NA hsa-miR-429 FGF2 6.39965293994036 1.96920201593608e-18 -4.7426237294682 2.88390048531716e-06 mirMAP -0.436553293587648 3.16850635903379e-09 NA NA NA hsa-let-7a-5p FGF5 0.148081801547773 0.645305441523746 0.200823087926326 0.886420744796129 TargetScan -0.813305940889404 0.00135260763770948 NA NA NA hsa-miR-30d-5p FGF5 0.302504510257496 0.380193536606962 0.200823087926326 0.886420744796129 mirMAP -0.945453857735156 5.5835570510599e-05 NA NA NA hsa-miR-30e-5p FGF5 0.780047227271616 0.0346714425913016 0.200823087926326 0.886420744796129 mirMAP -1.10490128001329 3.05121006892414e-07 NA NA NA hsa-miR-9-5p FGF5 1.79620806707734 0.14526963042518 0.200823087926326 0.886420744796129 mirMAP;miRNATAP -0.175560006282005 0.00635183798944373 NA NA NA hsa-let-7f-1-3p FGF7 1.61507869803314 0.00069342464777815 -5.50929759175591 2.08834235862861e-09 MirTarget -0.504915790636748 6.53452218850079e-06 NA NA NA hsa-miR-107 FGF7 1.49443409571439 0.000130594521065411 -5.50929759175591 2.08834235862861e-09 PITA;miRanda;miRNATAP -0.548261828442942 6.19267572946103e-05 NA NA NA hsa-miR-15a-5p FGF7 2.0535411006904 1.91108976398046e-06 -5.50929759175591 2.08834235862861e-09 miRTarBase;miRNATAP -0.844172026292795 1.5837696168512e-12 NA NA NA hsa-miR-15b-5p FGF7 3.32329949959268 8.40210501034588e-13 -5.50929759175591 2.08834235862861e-09 miRNATAP -0.7640679607102 1.57490618059424e-12 NA NA NA hsa-miR-16-1-3p FGF7 2.83281226969693 7.54359864580834e-09 -5.50929759175591 2.08834235862861e-09 mirMAP -0.749629628439643 4.52180322532678e-13 NA NA NA hsa-miR-16-2-3p FGF7 3.79845098071094 1.49120139344659e-13 -5.50929759175591 2.08834235862861e-09 mirMAP -0.847381900594552 4.32516753936814e-19 NA NA NA hsa-miR-16-5p FGF7 2.93575808220754 2.15436817162977e-10 -5.50929759175591 2.08834235862861e-09 miRNATAP -0.832832684493506 1.97867385329742e-14 NA NA NA hsa-miR-18a-3p FGF7 3.64944956993027 7.20156641833731e-07 -5.50929759175591 2.08834235862861e-09 MirTarget -0.441945882479192 2.84966542079581e-10 NA NA NA hsa-miR-20a-5p FGF7 2.13553469875764 0.000181201072324354 -5.50929759175591 2.08834235862861e-09 miRNAWalker2_validate -0.65813811876502 2.66086843741942e-13 NA NA NA hsa-miR-27a-3p FGF7 1.76094007417453 0.000216137556256765 -5.50929759175591 2.08834235862861e-09 MirTarget -0.395277535599951 0.000415972824808002 NA NA NA hsa-miR-30d-3p FGF7 -0.0740421896025512 0.857423650167556 -5.50929759175591 2.08834235862861e-09 miRNATAP -0.423853277659603 0.00128430415264874 NA NA NA hsa-miR-31-5p FGF7 7.15600983164746 6.64190917357724e-10 -5.50929759175591 2.08834235862861e-09 MirTarget -0.231105084817746 1.55520868035105e-07 NA NA NA hsa-miR-33a-3p FGF7 2.06269680799532 0.00156436055383943 -5.50929759175591 2.08834235862861e-09 mirMAP -0.324782867305881 6.90222589126918e-05 NA NA NA hsa-miR-429 FGF7 6.39965293994036 1.96920201593608e-18 -5.50929759175591 2.08834235862861e-09 miRNATAP -0.390059511354549 8.41914783540908e-09 NA NA NA hsa-miR-452-5p FGF7 2.45466810475361 0.00114794259949532 -5.50929759175591 2.08834235862861e-09 mirMAP -0.203492053036003 0.00386119935433002 NA NA NA hsa-miR-484 FGF7 1.79050445056016 0.000217287101253701 -5.50929759175591 2.08834235862861e-09 PITA -0.554919826238732 3.43164388632413e-07 NA NA NA hsa-miR-486-5p FGF7 1.10898145177457 0.309287974401609 -5.50929759175591 2.08834235862861e-09 MirTarget;miRanda -0.199101289167256 4.2632039983384e-05 NA NA NA hsa-miR-501-5p FGF7 1.0411896821345 0.0777206709183552 -5.50929759175591 2.08834235862861e-09 PITA;mirMAP -0.278893841915656 0.00214739894695432 NA NA NA hsa-miR-590-3p FGF7 2.35429565068338 2.79601879608564e-06 -5.50929759175591 2.08834235862861e-09 PITA;miRanda;mirMAP;miRNATAP -0.423372011062578 5.43468998349422e-05 NA NA NA hsa-miR-590-5p FGF7 1.51400888103768 0.0023888567923017 -5.50929759175591 2.08834235862861e-09 PITA;miRanda -0.510281508234044 1.57446299231047e-06 NA NA NA hsa-miR-616-5p FGF7 2.48416313933027 0.00318247475868827 -5.50929759175591 2.08834235862861e-09 mirMAP -0.370056256625251 2.39061229012998e-06 NA NA NA hsa-miR-7-1-3p FGF7 1.43074343339835 0.00471215970502094 -5.50929759175591 2.08834235862861e-09 mirMAP -0.274609644788141 0.00965187913472911 NA NA NA hsa-miR-142-3p FGF9 4.35304505457969 3.10014573651358e-10 -4.08682393789453 0.0107258337159531 miRanda -0.401753640799601 0.00167098844620533 NA NA NA hsa-miR-142-5p FGF9 3.95552531913424 1.49536283724079e-08 -4.08682393789453 0.0107258337159531 mirMAP -0.595282456453426 2.31469482732197e-06 NA NA NA hsa-miR-155-5p FGF9 2.81443182173772 7.42530504828797e-05 -4.08682393789453 0.0107258337159531 miRNATAP -0.519448274223347 3.79320362704427e-05 NA NA NA hsa-miR-15b-5p FGF9 3.32329949959268 8.40210501034588e-13 -4.08682393789453 0.0107258337159531 miRNATAP -0.57369666067076 0.00255066397006186 NA NA NA hsa-miR-16-2-3p FGF9 3.79845098071094 1.49120139344659e-13 -4.08682393789453 0.0107258337159531 mirMAP -0.737702008973209 1.35213419742742e-05 NA NA NA hsa-miR-16-5p FGF9 2.93575808220754 2.15436817162977e-10 -4.08682393789453 0.0107258337159531 miRNATAP -0.626240493508557 0.00114127711677494 NA NA NA hsa-miR-205-5p FGF9 8.08298115900323 3.83045179398654e-07 -4.08682393789453 0.0107258337159531 miRNATAP -0.407807926248114 3.31451700237078e-14 NA NA NA hsa-miR-221-5p FGF9 2.07459535854377 0.0757339015356929 -4.08682393789453 0.0107258337159531 miRNATAP -0.265306408034282 0.000712187163376646 NA NA NA hsa-miR-330-5p FGF9 2.25110496739954 0.000275527655397415 -4.08682393789453 0.0107258337159531 miRanda;miRNATAP -0.87177733723282 1.06930871304638e-09 NA NA NA hsa-miR-582-5p FGF9 0.685177900016753 0.447761540297692 -4.08682393789453 0.0107258337159531 miRNATAP -0.314179765499692 0.00182764604876116 NA NA NA hsa-miR-590-3p FGF9 2.35429565068338 2.79601879608564e-06 -4.08682393789453 0.0107258337159531 miRanda;mirMAP -0.664491628866496 0.000203762257139799 NA NA NA hsa-miR-944 FGF9 7.20925181386398 0.000823207457340648 -4.08682393789453 0.0107258337159531 mirMAP -0.416792870999897 4.0818129784972e-17 NA NA NA hsa-miR-106b-5p FGFR1 2.80565545918114 1.14547999022566e-09 -3.68099244503292 0.000117634214619712 mirMAP -0.32757862591401 0.00493739743042474 NA NA NA hsa-miR-15a-5p FGFR1 2.0535411006904 1.91108976398046e-06 -3.68099244503292 0.000117634214619712 miRNATAP -0.446444424510866 0.000387045493423854 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-5p FGFR1 2.93575808220754 2.15436817162977e-10 -3.68099244503292 0.000117634214619712 miRTarBase;miRNATAP -0.563686110844188 8.1915486423705e-07 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-200b-5p FGFR1 6.81954246537908 6.31100593281326e-24 -3.68099244503292 0.000117634214619712 mirMAP -0.204584689815958 0.00635940451614134 NA NA NA hsa-miR-330-3p FGFR1 2.49094236945806 0.000129367003214715 -3.68099244503292 0.000117634214619712 PITA;miRNATAP -0.379471838740622 4.59253778797009e-06 NA NA NA hsa-miR-330-5p FGFR1 2.25110496739954 0.000275527655397415 -3.68099244503292 0.000117634214619712 miRanda;miRNATAP -0.441444867608315 3.45510180905413e-07 NA NA NA hsa-miR-590-3p FGFR1 2.35429565068338 2.79601879608564e-06 -3.68099244503292 0.000117634214619712 miRanda;mirMAP -0.348430851362078 0.00121803566976507 NA NA NA hsa-miR-146b-5p FGFR2 1.87569569182453 0.000737241069698886 -1.54795077473676 0.070591459239545 miRanda -0.298378342872546 0.000592636062336762 NA NA NA hsa-miR-330-5p FGFR2 2.25110496739954 0.000275527655397415 -1.54795077473676 0.070591459239545 miRanda -0.389349119984991 4.06955034955631e-07 NA NA NA hsa-miR-338-3p FGFR2 0.447551118940466 0.558485097370031 -1.54795077473676 0.070591459239545 miRanda;miRNATAP -0.19939075618371 0.00167905513044275 NA NA NA hsa-miR-194-5p FGFR3 0.691219038144468 0.523143086635506 3.48521641699525 0.00307155788964699 miRNATAP -0.211217272614244 0.000618688146002221 NA NA NA hsa-miR-99b-5p FGFR3 -0.796155507439137 0.153001114953768 3.48521641699525 0.00307155788964699 MirTarget;miRNATAP -0.821514573127916 2.25366377381863e-12 22969861 miR-99b was downregulated and FGFR3 was upregulated in lung cancer patients; We demonstrated that the overexpression of miR-99b induced a reduction in FGFR3 expression and confirmed the target specificity between miR-99b and the FGFR3 3'-untranslated region by luciferase reporter assay; Taken together these results suggest that miR-99b may be a tumor suppressor through the downregulation of FGFR3 miR-99b may be a potent tumor suppressor and may be a potential therapeutic tool for patients with lung cancer lung squamous cell cancer hsa-miR-106a-5p FLT1 3.98693608217557 9.37722470816656e-07 -2.50880932627343 2.11545598083473e-05 MirTarget;miRNATAP -0.150649076993949 0.000211832498871512 NA NA NA hsa-miR-200b-3p FLT1 5.56167217794639 6.43540045061709e-16 -2.50880932627343 2.11545598083473e-05 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.232867547380079 4.4840692649334e-07 21115742 Forced miR-200 expression suppressed Flt1 levels in metastasis-prone lung adenocarcinoma cells derived from K-ras/p53-mutant mice and negatively regulated the Flt1 3'-UTR in reporter assays; We conclude that miR-200 suppresses lung tumorigenesis by targeting Flt1 metastasis;tumorigenesis lung cancer hsa-miR-200c-3p FLT1 6.47012025883743 2.64500707716408e-26 -2.50880932627343 2.11545598083473e-05 miRNAWalker2_validate;miRTarBase;MirTarget -0.219736582761241 1.38560548333365e-05 NA NA NA hsa-miR-224-5p FLT1 4.2725754042941 6.99983365278436e-06 -2.50880932627343 2.11545598083473e-05 mirMAP -0.171656465263095 6.63665724367085e-07 NA NA NA hsa-miR-3065-5p FLT1 2.14185373842821 0.0609400502269891 -2.50880932627343 2.11545598083473e-05 miRNATAP -0.133851129249961 0.000259093549030172 NA NA NA hsa-miR-378a-3p FLT1 1.46612141870273 0.0466660641196872 -2.50880932627343 2.11545598083473e-05 MirTarget -0.204842613061931 6.39263826047401e-06 NA NA NA hsa-miR-378c FLT1 0.449601775771001 0.4993814483956 -2.50880932627343 2.11545598083473e-05 MirTarget -0.265708947619281 1.23216375475393e-07 NA NA NA hsa-miR-429 FLT1 6.39965293994036 1.96920201593608e-18 -2.50880932627343 2.11545598083473e-05 MirTarget;miRanda;miRNATAP -0.200829498343813 3.30630305503934e-06 NA NA NA hsa-miR-708-5p FLT1 1.70409736218557 0.0319538709865338 -2.50880932627343 2.11545598083473e-05 MirTarget -0.120470927748041 0.00456170286572504 NA NA NA hsa-miR-491-5p FLT3LG 0.569358547192776 0.313310594748302 -0.93475849684924 0.13952149763963 miRanda -0.169160340907674 0.00904530363251358 NA NA NA hsa-miR-429 FLT4 6.39965293994036 1.96920201593608e-18 -3.43739473776613 1.81861358368246e-07 miRanda;miRNATAP -0.238655793143958 8.60877876275702e-07 NA NA NA hsa-let-7g-5p FN1 0.857251702023746 0.00647597344297273 -1.36144636221369 0.250505962748653 miRTarBase -0.903563051022715 2.98249474336263e-05 NA NA NA hsa-miR-16-1-3p FN1 2.83281226969693 7.54359864580834e-09 -1.36144636221369 0.250505962748653 mirMAP -0.453331376891726 0.000725705336567709 NA NA NA hsa-miR-200b-3p FN1 5.56167217794639 6.43540045061709e-16 -1.36144636221369 0.250505962748653 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.638482901225541 1.10651140093297e-12 24391862 In contrast mesenchymal markers fibronectin and vimentin were significantly downregulated by miR-200 b prostate cancer hsa-miR-200c-3p FN1 6.47012025883743 2.64500707716408e-26 -1.36144636221369 0.250505962748653 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.527098065662119 1.20069978407088e-07 NA NA NA hsa-miR-33a-3p FN1 2.06269680799532 0.00156436055383943 -1.36144636221369 0.250505962748653 mirMAP -0.317910914603669 0.00198782552519901 NA NA NA hsa-miR-429 FN1 6.39965293994036 1.96920201593608e-18 -1.36144636221369 0.250505962748653 MirTarget;PITA;miRanda;miRNATAP -0.489245625265544 8.21510685952814e-09 NA NA NA hsa-miR-96-5p FN1 5.62521466029286 1.54938806718028e-10 -1.36144636221369 0.250505962748653 MirTarget;TargetScan -0.234847002718398 0.00970463192782325 NA NA NA hsa-miR-155-5p FOXO3 2.81443182173772 7.42530504828797e-05 -1.11663353040891 0.00130099122148687 miRNAWalker2_validate;miRTarBase -0.127076961814372 2.89414570079369e-06 27596294;25480585;20371610;26398931;22027557;27107135 MiR-155 targets 3´UTR region of multiple components of the pro-oncogenic signaling cascades including FOXO3a tumor suppressor and RUNX2 transcription factor regulating metastatic potential in BC;The effect of miRNA155 on FOXO3a expression was examined by Western blotting; FOXO3a was found to be a possible target of miRNA155 as suggested by Targetscan website;MicroRNA 155 regulates cell survival growth and chemosensitivity by targeting FOXO3a in breast cancer; In this study we demonstrate the critical role of miR-155 in regulation of cell survival and chemosensitivity through down-regulation of FOXO3a in breast cancer; Further we identified FOXO3a as a direct target of miR-155; Sustained overexpression of miR-155 resulted in repression of FOXO3a protein without changing mRNA levels and knockdown of miR-155 increases FOXO3a; Finally inverse correlation between miR-155 and FOXO3a levels were observed in a panel of breast cancer cell lines and tumors; In conclusion our study reveals a molecular link between miR-155 and FOXO3a and presents evidence that miR-155 is a critical therapeutic target in breast cancer;In contrast downregulation of miR-155-5p increased sensitivity to bufalin and upregulated the expression of FOXO3A;Here we show that hypoxic conditions induce miR-155 expression in lung cancer cells and trigger a corresponding decrease in a validated target FOXO3A;Our results further revealed that forkhead box O3a FoxO3a was a miR-155 target in the heart; And miR-155 directly repressed FoxO3a whose expression was mitigated in miR-155 agomir and mimic treatment in vivo and in vitro ;;poor survival;;; breast cancer;lymphoma;breast cancer;breast cancer;lung cancer;breast cancer hsa-miR-27a-3p FOXO3 1.76094007417453 0.000216137556256765 -1.11663353040891 0.00130099122148687 miRNATAP -0.121455499405924 0.0033147456416465 23621269 FOXO3a was verified as a new target of miR-27a by Western blotting and reporter analyzes glioblastoma hsa-miR-29a-3p FOXO3 -0.638239697975974 0.251923581881716 -1.11663353040891 0.00130099122148687 miRNATAP -0.133870497648249 0.000155522790180983 NA NA NA hsa-miR-29a-5p FOXO3 0.0748295222568571 0.884125894063293 -1.11663353040891 0.00130099122148687 mirMAP -0.12522821936667 0.0011896805089702 NA NA NA hsa-miR-29b-3p FOXO3 0.666547117072858 0.234055379278093 -1.11663353040891 0.00130099122148687 miRNATAP -0.183045594867343 1.46440074656889e-07 NA NA NA hsa-miR-29c-3p FOXO3 -0.414153610337085 0.529344128062017 -1.11663353040891 0.00130099122148687 miRNATAP -0.100552365745649 0.000788751054503897 NA NA NA hsa-miR-320c FOXO3 -0.10618808730545 0.854002814666472 -1.11663353040891 0.00130099122148687 mirMAP;miRNATAP -0.109911608109279 0.00165827020955325 NA NA NA hsa-miR-590-3p FOXO3 2.35429565068338 2.79601879608564e-06 -1.11663353040891 0.00130099122148687 PITA;miRanda;mirMAP;miRNATAP -0.174292245139627 5.93124667931455e-06 NA NA NA hsa-miR-590-5p FOXO3 1.51400888103768 0.0023888567923017 -1.11663353040891 0.00130099122148687 miRanda -0.109158802099976 0.00586211371258922 NA NA NA hsa-miR-664a-3p FOXO3 0.249882351950296 0.56171157318348 -1.11663353040891 0.00130099122148687 mirMAP -0.132280214604048 0.00434722396559561 NA NA NA hsa-miR-15a-5p GHR 2.0535411006904 1.91108976398046e-06 -3.30441572530682 0.0133498021134927 MirTarget;miRNATAP -0.681154907599641 9.24104831714877e-05 NA NA NA hsa-miR-15b-5p GHR 3.32329949959268 8.40210501034588e-13 -3.30441572530682 0.0133498021134927 MirTarget;miRNATAP -0.517993741994565 0.00106382975468503 NA NA NA hsa-miR-16-2-3p GHR 3.79845098071094 1.49120139344659e-13 -3.30441572530682 0.0133498021134927 mirMAP -0.501720617358561 0.000411619192161155 NA NA NA hsa-miR-16-5p GHR 2.93575808220754 2.15436817162977e-10 -3.30441572530682 0.0133498021134927 MirTarget;miRNATAP -0.561520754201017 0.000456953779533557 NA NA NA hsa-miR-3065-5p GHR 2.14185373842821 0.0609400502269891 -3.30441572530682 0.0133498021134927 MirTarget -0.382624986901816 2.82575815241532e-06 NA NA NA hsa-miR-338-5p GHR -0.108304629897487 0.894675560494607 -3.30441572530682 0.0133498021134927 PITA -0.502767794585058 4.25333085957161e-08 NA NA NA hsa-miR-7-1-3p GHR 1.43074343339835 0.00471215970502094 -3.30441572530682 0.0133498021134927 MirTarget;mirMAP -0.409557384279444 0.00647708206229191 NA NA NA hsa-miR-330-5p GNB3 2.25110496739954 0.000275527655397415 -1.72168164400184 0.0440034082927346 miRanda -0.268595227971439 0.000541834407487176 NA NA NA hsa-miR-103a-2-5p GNB4 2.77240253557299 0.000302548514615442 0.33692917907156 0.55753423599022 MirTarget -0.117475120467142 0.00569963630046973 NA NA NA hsa-miR-338-5p GNB4 -0.108304629897487 0.894675560494607 0.33692917907156 0.55753423599022 MirTarget -0.103426923599829 0.00964539952114893 NA NA NA hsa-miR-429 GNB4 6.39965293994036 1.96920201593608e-18 0.33692917907156 0.55753423599022 miRanda -0.118308552846652 0.00475153147668862 NA NA NA hsa-miR-501-5p GNB4 1.0411896821345 0.0777206709183552 0.33692917907156 0.55753423599022 mirMAP -0.193251950150551 0.000438293257223539 NA NA NA hsa-miR-96-5p GNB4 5.62521466029286 1.54938806718028e-10 0.33692917907156 0.55753423599022 MirTarget -0.149612510658778 0.000626381721610319 NA NA NA hsa-miR-342-3p GNB5 1.31107714473009 0.0207211910724662 -1.03280589398825 0.00426339571585526 miRanda -0.119126703902425 0.000974845839373698 NA NA NA hsa-miR-107 GNG12 1.49443409571439 0.000130594521065411 -0.886730549936608 0.0548755138724675 miRanda -0.375379591214763 1.2611761046531e-08 NA NA NA hsa-miR-186-5p GNG12 0.445443449112564 0.185447310527704 -0.886730549936608 0.0548755138724675 miRNAWalker2_validate -0.367159470028634 3.06448364501308e-06 NA NA NA hsa-miR-28-5p GNG12 -0.815636722979196 0.0221199948901761 -0.886730549936608 0.0548755138724675 PITA;miRanda -0.21959951908093 0.00323834417968406 NA NA NA hsa-miR-30d-3p GNG12 -0.0740421896025512 0.857423650167556 -0.886730549936608 0.0548755138724675 mirMAP -0.294933914805506 3.66263698042787e-06 NA NA NA hsa-miR-423-5p GNG12 0.227366878624794 0.5653498335202 -0.886730549936608 0.0548755138724675 miRNAWalker2_validate -0.257155822338734 0.000119401413269023 NA NA NA hsa-miR-429 GNG12 6.39965293994036 1.96920201593608e-18 -0.886730549936608 0.0548755138724675 miRanda -0.174749824561321 1.42475980670021e-07 NA NA NA hsa-miR-590-3p GNG12 2.35429565068338 2.79601879608564e-06 -0.886730549936608 0.0548755138724675 miRanda;mirMAP -0.195519764941412 0.000137706236894006 NA NA NA hsa-miR-590-5p GNG12 1.51400888103768 0.0023888567923017 -0.886730549936608 0.0548755138724675 PITA -0.204130947938636 9.24784233305571e-05 NA NA NA hsa-miR-96-5p GNG12 5.62521466029286 1.54938806718028e-10 -0.886730549936608 0.0548755138724675 TargetScan -0.227994483286262 3.07845742736986e-11 NA NA NA hsa-miR-130a-5p GNG2 1.58028512890005 0.024346333013728 -1.63388238277818 0.0096033377138479 miRNATAP -0.153940264478304 0.00302187050547871 NA NA NA hsa-miR-3065-5p GNG2 2.14185373842821 0.0609400502269891 -1.63388238277818 0.0096033377138479 mirMAP;miRNATAP -0.172306337991751 8.16642921470124e-06 NA NA NA hsa-miR-30d-3p GNG2 -0.0740421896025512 0.857423650167556 -1.63388238277818 0.0096033377138479 mirMAP -0.251385745874118 0.00441845513761904 NA NA NA hsa-miR-324-5p GNG2 1.31253452379847 0.0116806680545163 -1.63388238277818 0.0096033377138479 miRanda -0.181892767416293 0.00851087786750887 NA NA NA hsa-miR-335-3p GNG2 1.19503568251824 0.0938852560631551 -1.63388238277818 0.0096033377138479 mirMAP -0.175129993471986 0.000472305207827628 NA NA NA hsa-miR-429 GNG2 6.39965293994036 1.96920201593608e-18 -1.63388238277818 0.0096033377138479 miRanda;miRNATAP -0.297769073591148 3.50719868301774e-11 NA NA NA hsa-miR-142-5p GNG4 3.95552531913424 1.49536283724079e-08 -1.72959615195693 0.248482768586673 mirMAP -0.453045594746171 0.000125658039660901 NA NA NA hsa-miR-29a-5p GNG4 0.0748295222568571 0.884125894063293 -1.72959615195693 0.248482768586673 mirMAP -0.554604579642782 0.000856186027296986 NA NA NA hsa-miR-342-3p GNG4 1.31107714473009 0.0207211910724662 -1.72959615195693 0.248482768586673 mirMAP -0.415755822836141 0.00561426482329921 NA NA NA hsa-miR-1271-5p GNG7 0.212382644103427 0.742544160267329 -4.49517936361256 3.6233954247073e-08 mirMAP -0.240345582643108 0.00105591850412261 NA NA NA hsa-miR-130a-5p GNG7 1.58028512890005 0.024346333013728 -4.49517936361256 3.6233954247073e-08 mirMAP -0.286724038787784 2.47101215862532e-05 NA NA NA hsa-miR-141-3p GNG7 7.30474126597325 1.45115996357606e-24 -4.49517936361256 3.6233954247073e-08 MirTarget;TargetScan;miRNATAP -0.363973774874477 1.10434201985659e-09 NA NA NA hsa-miR-17-3p GNG7 1.2477858204856 0.00186593270231258 -4.49517936361256 3.6233954247073e-08 mirMAP -0.655161490243068 1.94791547784036e-08 NA NA NA hsa-miR-182-5p GNG7 5.86988712704738 1.22411588571584e-15 -4.49517936361256 3.6233954247073e-08 mirMAP -0.254428389251722 2.97466815803603e-05 NA NA NA hsa-miR-185-3p GNG7 2.44625550129147 0.000878038743901412 -4.49517936361256 3.6233954247073e-08 mirMAP -0.222649623184671 0.00454520693874154 NA NA NA hsa-miR-18a-3p GNG7 3.64944956993027 7.20156641833731e-07 -4.49517936361256 3.6233954247073e-08 mirMAP -0.379088322323101 9.79452523392171e-10 NA NA NA hsa-miR-18a-5p GNG7 3.90770175770219 9.15298615034137e-10 -4.49517936361256 3.6233954247073e-08 mirMAP -0.427945029550305 1.31010898115278e-09 NA NA NA hsa-miR-193b-5p GNG7 0.448438597554777 0.565875535989548 -4.49517936361256 3.6233954247073e-08 mirMAP -0.20047301375223 0.000916656346346483 NA NA NA hsa-miR-1976 GNG7 3.27217274919653 3.16337235854532e-12 -4.49517936361256 3.6233954247073e-08 mirMAP -0.333171546189553 0.000641702601143187 NA NA NA hsa-miR-200a-3p GNG7 6.336081120041 4.024313571871e-16 -4.49517936361256 3.6233954247073e-08 MirTarget;miRNATAP -0.307812653397717 5.75243023841078e-08 NA NA NA hsa-miR-22-5p GNG7 2.38337850108621 1.0773503998394e-05 -4.49517936361256 3.6233954247073e-08 mirMAP -0.241510322110778 0.0052895109011869 NA NA NA hsa-miR-224-5p GNG7 4.2725754042941 6.99983365278436e-06 -4.49517936361256 3.6233954247073e-08 mirMAP -0.153622350564763 0.00166431857957028 NA NA NA hsa-miR-23a-3p GNG7 0.925125296618358 0.0127293543936914 -4.49517936361256 3.6233954247073e-08 mirMAP -0.440886886291531 0.000621388470909688 NA NA NA hsa-miR-31-3p GNG7 5.7035081317825 2.15133648211091e-05 -4.49517936361256 3.6233954247073e-08 mirMAP -0.21345967319356 3.73434807493034e-07 NA NA NA hsa-miR-31-5p GNG7 7.15600983164746 6.64190917357724e-10 -4.49517936361256 3.6233954247073e-08 mirMAP -0.194960608212519 5.73248513100339e-07 NA NA NA hsa-miR-3127-5p GNG7 0.941647403878801 0.124512093133103 -4.49517936361256 3.6233954247073e-08 mirMAP -0.236538546926252 0.0022460299064856 NA NA NA hsa-miR-330-5p GNG7 2.25110496739954 0.000275527655397415 -4.49517936361256 3.6233954247073e-08 mirMAP -0.206441383507389 0.00659102802128825 NA NA NA hsa-miR-3615 GNG7 2.00888751637278 0.000397875472856691 -4.49517936361256 3.6233954247073e-08 mirMAP -0.280893520383327 0.000693172517590129 NA NA NA hsa-miR-616-5p GNG7 2.48416313933027 0.00318247475868827 -4.49517936361256 3.6233954247073e-08 MirTarget -0.19257221362114 0.00602830745303123 NA NA NA hsa-miR-9-5p GNG7 1.79620806707734 0.14526963042518 -4.49517936361256 3.6233954247073e-08 mirMAP -0.112835478215396 0.00313577508524784 NA NA NA hsa-miR-92a-3p GNG7 1.87892405805529 1.27013821556583e-05 -4.49517936361256 3.6233954247073e-08 miRNAWalker2_validate -0.77887201955376 1.67509299900751e-13 NA NA NA hsa-miR-940 GNG7 3.78496690968119 4.75227557809023e-05 -4.49517936361256 3.6233954247073e-08 MirTarget -0.243248841385255 6.92856970987846e-05 NA NA NA hsa-miR-96-5p GNG7 5.62521466029286 1.54938806718028e-10 -4.49517936361256 3.6233954247073e-08 mirMAP -0.241500488826132 0.000146095026839275 NA NA NA hsa-miR-219a-1-3p GNGT2 2.00224769738217 0.0010023437369814 -0.830867872962711 0.283361566717256 MirTarget -0.204924693004807 0.00428106302342682 NA NA NA hsa-miR-30c-2-3p GNGT2 -0.916427677918778 0.300195789569016 -0.830867872962711 0.283361566717256 MirTarget -0.170177078816628 0.000567340873522604 NA NA NA hsa-miR-335-5p GNGT2 0.167216045757305 0.803897055331049 -0.830867872962711 0.283361566717256 miRNAWalker2_validate -0.228427620496161 0.000447825861469557 NA NA NA hsa-miR-181c-5p GSK3B -0.302833440762172 0.537532549455539 0.984264794042029 0.00614784819440891 mirMAP -0.115369483842179 0.00582165998524454 NA NA NA hsa-miR-30a-3p GSK3B -1.22212086897848 0.167565797592104 0.984264794042029 0.00614784819440891 miRNATAP -0.11517576765646 3.57050461951731e-07 NA NA NA hsa-miR-30d-3p GSK3B -0.0740421896025512 0.857423650167556 0.984264794042029 0.00614784819440891 miRNATAP -0.217356687168476 1.21966436788369e-05 NA NA NA hsa-miR-320c GSK3B -0.10618808730545 0.854002814666472 0.984264794042029 0.00614784819440891 miRanda;mirMAP -0.100605875350465 0.00537879672016752 NA NA NA hsa-miR-362-5p GSK3B -1.22309034685697 0.0452665543907975 0.984264794042029 0.00614784819440891 miRNATAP -0.116235509089146 0.000473661337943669 NA NA NA hsa-let-7f-1-3p HGF 1.61507869803314 0.00069342464777815 -3.90177127926037 9.33819406271226e-05 mirMAP -0.537655519322627 7.00715676350499e-06 NA NA NA hsa-miR-141-3p HGF 7.30474126597325 1.45115996357606e-24 -3.90177127926037 9.33819406271226e-05 MirTarget;TargetScan -0.407936076663434 1.88518993661496e-08 NA NA NA hsa-miR-200a-3p HGF 6.336081120041 4.024313571871e-16 -3.90177127926037 9.33819406271226e-05 MirTarget -0.280888359064684 5.08617365666383e-05 NA NA NA hsa-miR-203a-3p HGF 6.35084246337388 7.89944323347948e-08 -3.90177127926037 9.33819406271226e-05 MirTarget -0.204595731578258 1.21386978961366e-05 NA NA NA hsa-miR-335-3p HGF 1.19503568251824 0.0938852560631551 -3.90177127926037 9.33819406271226e-05 mirMAP -0.273560280003382 0.00062323466706546 NA NA NA hsa-miR-33a-3p HGF 2.06269680799532 0.00156436055383943 -3.90177127926037 9.33819406271226e-05 mirMAP -0.326603422809417 0.000183515930533633 NA NA NA hsa-miR-34c-5p HGF 2.64675661251039 0.0157394735757952 -3.90177127926037 9.33819406271226e-05 miRanda -0.139605145794652 0.00726083502207088 NA NA NA hsa-miR-429 HGF 6.39965293994036 1.96920201593608e-18 -3.90177127926037 9.33819406271226e-05 miRanda -0.31974260136447 1.24182213618931e-05 NA NA NA hsa-miR-590-5p HGF 1.51400888103768 0.0023888567923017 -3.90177127926037 9.33819406271226e-05 miRanda -0.299588124426935 0.00920372465137889 NA NA NA hsa-miR-651-5p HGF 2.63593644285064 2.87092871839488e-05 -3.90177127926037 9.33819406271226e-05 MirTarget -0.267594273381361 0.00293543373205292 NA NA NA hsa-miR-944 HGF 7.20925181386398 0.000823207457340648 -3.90177127926037 9.33819406271226e-05 mirMAP -0.118743424839016 0.00026536217515452 NA NA NA hsa-miR-30e-5p HSP90AA1 0.780047227271616 0.0346714425913016 0.894381868425105 0.003663432676245 miRNAWalker2_validate -0.141684608356368 0.00310231797808728 NA NA NA hsa-miR-199b-5p IBSP -0.53728867775768 0.476885702455766 3.49686751641896 0.0120242931922719 miRanda -0.312137109055721 0.00293302450759069 NA NA NA hsa-miR-1271-5p IFNAR2 0.212382644103427 0.742544160267329 -0.0533929917619993 0.876582967690528 mirMAP -0.126034803018463 2.42204092211989e-05 NA NA NA hsa-let-7f-1-3p IGF1 1.61507869803314 0.00069342464777815 -4.48455379412262 0.00149155200072234 mirMAP -0.918829913577652 3.87495776454398e-08 NA NA NA hsa-miR-103a-2-5p IGF1 2.77240253557299 0.000302548514615442 -4.48455379412262 0.00149155200072234 mirMAP -0.614783124207912 2.47565479190434e-09 NA NA NA hsa-miR-130b-3p IGF1 3.9204771543282 1.2714917955808e-11 -4.48455379412262 0.00149155200072234 MirTarget -0.479757958716119 0.000356022414865848 NA NA NA hsa-miR-15b-3p IGF1 3.57530146629867 5.89922785773482e-11 -4.48455379412262 0.00149155200072234 mirMAP -0.729097685666816 2.48630408177257e-07 NA NA NA hsa-miR-16-1-3p IGF1 2.83281226969693 7.54359864580834e-09 -4.48455379412262 0.00149155200072234 mirMAP -0.814562134768682 3.05533338766364e-07 NA NA NA hsa-miR-19a-3p IGF1 2.17020503944519 0.00122084653711062 -4.48455379412262 0.00149155200072234 MirTarget -0.581899015817695 7.91751221290163e-07 NA NA NA hsa-miR-19b-1-5p IGF1 1.51335451095424 0.0014717605268143 -4.48455379412262 0.00149155200072234 mirMAP -1.02209573815554 6.70473912999913e-10 NA NA NA hsa-miR-19b-3p IGF1 1.67581705793313 0.000858910586302716 -4.48455379412262 0.00149155200072234 MirTarget -0.831868934390103 1.31473916022842e-07 NA NA NA hsa-miR-20a-3p IGF1 1.9920766549842 0.000624458530894697 -4.48455379412262 0.00149155200072234 mirMAP -0.765905368079341 1.45024350852968e-08 NA NA NA hsa-miR-27a-3p IGF1 1.76094007417453 0.000216137556256765 -4.48455379412262 0.00149155200072234 miRNAWalker2_validate;miRTarBase -1.09876415117095 2.18608056227336e-11 NA NA NA hsa-miR-301a-3p IGF1 1.99338115332667 0.000813358604963724 -4.48455379412262 0.00149155200072234 MirTarget -0.46409260853426 0.000552061816042968 NA NA NA hsa-miR-32-3p IGF1 2.20477794939766 0.0392771274032852 -4.48455379412262 0.00149155200072234 mirMAP -0.547975732700196 3.20639423670354e-05 NA NA NA hsa-miR-33a-3p IGF1 2.06269680799532 0.00156436055383943 -4.48455379412262 0.00149155200072234 MirTarget -0.400091789613134 0.00117684573706475 NA NA NA hsa-miR-452-5p IGF1 2.45466810475361 0.00114794259949532 -4.48455379412262 0.00149155200072234 MirTarget;mirMAP -0.28989018336422 0.00626092588038326 NA NA NA hsa-miR-486-5p IGF1 1.10898145177457 0.309287974401609 -4.48455379412262 0.00149155200072234 PITA;miRNATAP -0.349556791581636 1.58501267453983e-06 NA NA NA hsa-miR-576-5p IGF1 1.30320223793746 0.00648929463912994 -4.48455379412262 0.00149155200072234 PITA;mirMAP;miRNATAP -0.686331142925331 4.29578185739691e-05 NA NA NA hsa-miR-629-5p IGF1 1.57164125641392 0.0115716388531198 -4.48455379412262 0.00149155200072234 mirMAP -0.4282336374449 0.000902416424835987 NA NA NA hsa-miR-940 IGF1 3.78496690968119 4.75227557809023e-05 -4.48455379412262 0.00149155200072234 MirTarget;PITA;miRNATAP -0.340594099196604 0.00112659190128122 NA NA NA hsa-let-7c-5p IGF1R -2.03831836681378 0.0228401148731997 -0.352375681657302 0.589588982107528 MirTarget -0.172064230498856 2.41594489287559e-05 NA NA NA hsa-let-7g-5p IGF1R 0.857251702023746 0.00647597344297273 -0.352375681657302 0.589588982107528 MirTarget;miRNATAP -0.323883595511497 0.00699299701938087 NA NA NA hsa-miR-125b-5p IGF1R -2.01187572101832 0.00516480893645494 -0.352375681657302 0.589588982107528 mirMAP -0.157651644805227 0.0020219171607943 NA NA NA hsa-miR-148a-5p IGF1R 1.31769244477686 0.0507400532963856 -0.352375681657302 0.589588982107528 mirMAP -0.237033458281659 1.25771430876605e-05 NA NA NA hsa-miR-150-5p IGF1R 1.76769157530064 0.0593795975117846 -0.352375681657302 0.589588982107528 mirMAP -0.129699270963092 0.000930785675337446 NA NA NA hsa-miR-192-5p IGF1R 1.77716187978541 0.113485496183047 -0.352375681657302 0.589588982107528 miRNAWalker2_validate -0.174491020527491 6.12567949251227e-08 NA NA NA hsa-miR-194-3p IGF1R 1.91743783341496 0.105383373371284 -0.352375681657302 0.589588982107528 MirTarget -0.129488093186892 3.21928226407823e-05 NA NA NA hsa-miR-194-5p IGF1R 0.691219038144468 0.523143086635506 -0.352375681657302 0.589588982107528 miRNAWalker2_validate;miRTarBase;miRNATAP -0.1882359408287 1.77867782978563e-08 NA NA NA hsa-miR-215-5p IGF1R 3.66990923176752 0.00294614570694381 -0.352375681657302 0.589588982107528 miRNAWalker2_validate -0.170735568045218 4.32194073338045e-09 NA NA NA hsa-miR-26b-3p IGF1R 0.985177548213122 0.0351427970185971 -0.352375681657302 0.589588982107528 miRNATAP -0.252587033843176 0.00146920805438293 NA NA NA hsa-miR-29b-2-5p IGF1R -0.596051745078872 0.189540844841389 -0.352375681657302 0.589588982107528 mirMAP -0.338197355923814 3.34796824559741e-05 NA NA NA hsa-miR-29c-3p IGF1R -0.414153610337085 0.529344128062017 -0.352375681657302 0.589588982107528 mirMAP -0.185102979207723 0.00097708255137931 NA NA NA hsa-miR-342-5p IGF1R 1.3865615438184 0.0153598969109545 -0.352375681657302 0.589588982107528 mirMAP -0.207207474542234 0.00131890342050949 NA NA NA hsa-miR-375 IGF1R 3.3784490463318 0.0449946294355695 -0.352375681657302 0.589588982107528 miRNATAP -0.100828672615529 2.86018163408669e-06 27129171;24571711;21813472 Together these results show that AE modulates cancer cells and the tumor microenvironment via activation of miR-375 and by targeting IGF1R and SNAIL1 in OC cells;Epigenetic silencing of miR 375 induces trastuzumab resistance in HER2 positive breast cancer by targeting IGF1R; miR-375 which was downregulated and predicted to target IGF1R in trastuzumab-resistant HER2-positive breast cancer cells could indeed inhibit the cellular luciferase activity in a reporter construct containing the 3'-UTR of IGF1R; A reverse correlation between the levels of miR-375 and IGF1R was validated in clinical breast cancers; Epigenetic silencing of miR-375 causes the upregulation of IGF1R which at least partially underlies trastuzumab resistance of breast cancer cells;Real-time quantitative PCR was applied to detectthe expression of miR-375 in ESCC samples and its correlation with insulin-like growth factor 1 receptor IGF1R; Further study showed that miR-375 could interact with the 3'-untranslated region of IGF1R and downregulate its expression; In clinical specimens the expression of IGF1R was also negatively correlated with miR-375 expression p=0.008; This study demonstrates that miR-375 has a strong tumour-suppressive effect through inhibiting the expression of IGF1R ;drug resistance; ovarian cancer;breast cancer;esophageal cancer hsa-miR-378a-5p IGF1R 1.25775140086104 0.0500877723587615 -0.352375681657302 0.589588982107528 mirMAP -0.173888375501911 0.00250354465994003 24119742;25427715 The insulin-like growth factor 1 receptor IGF1R was predicted as a potential target of miR-378 and luciferase reporter activity of IGF1R was significantly decreased in the HEK293 cells co-transfected with miR-378 by 41.8% vs the control cells P less than 0.01; miR-378 may suppress growth characteristics of HBV-related HCC by directly targeting the IGF1R 3'-UTR and inhibiting its protein expression;Interestingly members of the miR-378 family presented as a possible target the insulin-like growth factor receptor 1 IGF1R a key signalling molecule in RMS ; liver cancer;sarcoma hsa-miR-378c IGF1R 0.449601775771001 0.4993814483956 -0.352375681657302 0.589588982107528 MirTarget;miRNATAP -0.224627281553463 4.96401741172347e-05 NA NA NA hsa-miR-429 IGF1R 6.39965293994036 1.96920201593608e-18 -0.352375681657302 0.589588982107528 miRanda;miRNATAP -0.14382813700008 0.00252727989860566 NA NA NA hsa-miR-532-5p IGF1R -0.297424983759107 0.503934707453099 -0.352375681657302 0.589588982107528 miRNATAP -0.271711252028916 0.00118911156372278 NA NA NA hsa-miR-592 IGF1R 2.80403350008555 0.0293520213681333 -0.352375681657302 0.589588982107528 PITA;miRNATAP -0.175848642448248 3.86725044870693e-07 NA NA NA hsa-miR-625-5p IGF1R 2.02792641909347 0.000935142379948297 -0.352375681657302 0.589588982107528 MirTarget -0.225867159281351 0.000175914620896406 NA NA NA hsa-miR-99a-5p IGF1R -2.72139054000803 0.00621971944534118 -0.352375681657302 0.589588982107528 miRNAWalker2_validate;miRTarBase;miRNATAP -0.160661156530045 1.10343858783123e-05 22425712 Furthermore ectopic transfection of miR-99 family members down-regulated the expression of insulin-like growth factor 1 receptor IGF1R and mechanistic target of rapamycin mTOR genes; The deregulation of miR-99 family contributes to the tumorigenesis of HNSCC in part by targeting IGF1R and mTOR signaling pathways tumorigenesis head and neck cancer hsa-miR-141-3p IGF2 7.30474126597325 1.45115996357606e-24 -3.86786310058941 0.000390324998771923 MirTarget;TargetScan -0.310246925192677 0.000108351508982076 NA NA NA hsa-miR-210-3p IGF2 5.44331450504724 6.66962847973893e-09 -3.86786310058941 0.000390324998771923 MirTarget -0.250126732827733 9.94235578737043e-05 NA NA NA hsa-miR-23a-5p IGF2 2.86720096840797 0.000290788677230784 -3.86786310058941 0.000390324998771923 MirTarget -0.276224305470311 0.00038188605175421 NA NA NA hsa-miR-31-5p IGF2 7.15600983164746 6.64190917357724e-10 -3.86786310058941 0.000390324998771923 mirMAP -0.247695733958156 1.49140450221344e-06 NA NA NA hsa-miR-361-3p IGF2 0.805698609170807 0.0418491665498322 -3.86786310058941 0.000390324998771923 mirMAP -0.488498622515399 0.00217878707006209 NA NA NA hsa-miR-93-5p IGF2 2.65964181833033 2.58315947526774e-08 -3.86786310058941 0.000390324998771923 miRNAWalker2_validate -0.334678763517393 0.00930029353886574 NA NA NA hsa-miR-151a-3p IKBKB 0.373902859770645 0.376924505912903 0.104177496834708 0.718852918781577 miRNAWalker2_validate -0.121270812981731 0.00180898875297091 NA NA NA hsa-miR-339-5p IKBKB 1.23326828594484 0.0307501214818698 0.104177496834708 0.718852918781577 miRanda -0.112704791185609 7.01383121429463e-05 NA NA NA hsa-miR-542-3p IKBKB -0.376147863244659 0.438002751207043 0.104177496834708 0.718852918781577 miRanda -0.1114840138672 0.000952486304701064 NA NA NA hsa-miR-125a-5p IKBKG -1.32352790615388 0.00714301627309467 0.217673245627403 0.541287587904691 miRanda -0.110235437146931 0.00712043030373108 NA NA NA hsa-miR-338-5p IKBKG -0.108304629897487 0.894675560494607 0.217673245627403 0.541287587904691 mirMAP -0.107990652303128 1.00066234929907e-05 NA NA NA hsa-miR-199a-5p IL2RA -1.24888110793613 0.0747755616523728 2.59665250906558 0.00694516409433377 miRanda -0.280001757042261 0.000319245373954421 NA NA NA hsa-miR-3065-3p IL2RA 1.89496019576082 0.0308154823923145 2.59665250906558 0.00694516409433377 MirTarget -0.211093568337215 0.000660400303399024 NA NA NA hsa-miR-375 IL2RA 3.3784490463318 0.0449946294355695 2.59665250906558 0.00694516409433377 miRanda -0.179444535009697 1.45877104995161e-08 NA NA NA hsa-miR-500a-3p IL2RA 0.515751555939967 0.335082072556095 2.59665250906558 0.00694516409433377 MirTarget -0.308693938165126 0.00270159749620831 NA NA NA hsa-miR-145-5p IL2RB -3.55505374822025 5.45525288912869e-07 1.37836826636696 0.103487872894286 mirMAP -0.22134225926689 0.000836838852824373 NA NA NA hsa-miR-299-5p IL2RB -1.25990656735684 0.103526045570924 1.37836826636696 0.103487872894286 mirMAP -0.183200680637314 0.00368295140844831 NA NA NA hsa-miR-331-3p IL4R 2.60769294751513 3.84318952029483e-07 0.367232990824394 0.543445227259428 miRNAWalker2_validate -0.17555951987969 0.00755399043568841 NA NA NA hsa-miR-429 IL4R 6.39965293994036 1.96920201593608e-18 0.367232990824394 0.543445227259428 miRNATAP -0.211673427550519 1.16441959018182e-06 NA NA NA hsa-miR-491-5p IL4R 0.569358547192776 0.313310594748302 0.367232990824394 0.543445227259428 miRanda -0.192269800927414 0.00182061138467756 NA NA NA hsa-miR-429 IL6 6.39965293994036 1.96920201593608e-18 -0.812372330269044 0.556990548550307 miRanda -0.497764450854261 5.94299314121074e-07 NA NA NA hsa-miR-130a-5p IL6R 1.58028512890005 0.024346333013728 -1.31785211161377 0.119283125010066 MirTarget;miRNATAP -0.197154960184132 0.00453478423438423 NA NA NA hsa-miR-141-3p IL6R 7.30474126597325 1.45115996357606e-24 -1.31785211161377 0.119283125010066 MirTarget -0.18243024553302 0.0032330457577678 NA NA NA hsa-miR-182-5p IL6R 5.86988712704738 1.22411588571584e-15 -1.31785211161377 0.119283125010066 mirMAP -0.181775798059133 0.00348128970964907 NA NA NA hsa-miR-200a-3p IL6R 6.336081120041 4.024313571871e-16 -1.31785211161377 0.119283125010066 MirTarget -0.189664840614486 0.00116015340974738 NA NA NA hsa-miR-129-5p IL7 -2.66843722411409 0.00695783358331245 1.2709847744185 0.101426762909784 miRanda -0.210681735704013 2.08028542064594e-06 NA NA NA hsa-miR-335-3p IL7 1.19503568251824 0.0938852560631551 1.2709847744185 0.101426762909784 mirMAP -0.203178540524723 0.000956503373722724 NA NA NA hsa-miR-335-3p IL7R 1.19503568251824 0.0938852560631551 1.30570894046381 0.274343453036421 mirMAP -0.360345945479883 0.000134066551236259 NA NA NA hsa-miR-508-3p IL7R 0.975099105064348 0.439528954969797 1.30570894046381 0.274343453036421 mirMAP -0.213207042989268 7.38673595729549e-05 NA NA NA hsa-let-7a-3p INSR 0.82512001802525 0.0468122405194487 -1.82386828224005 0.000371643290248406 mirMAP -0.31797006181058 6.57321595352448e-06 NA NA NA hsa-let-7b-3p INSR 0.589364128513318 0.200507534602851 -1.82386828224005 0.000371643290248406 mirMAP -0.259315063651273 4.66833310700342e-05 NA NA NA hsa-let-7b-5p INSR -0.189422992330471 0.651878220048983 -1.82386828224005 0.000371643290248406 miRNATAP -0.196281386309409 0.00546205597318729 NA NA NA hsa-let-7f-1-3p INSR 1.61507869803314 0.00069342464777815 -1.82386828224005 0.000371643290248406 mirMAP -0.362077718145206 2.01523274963456e-09 NA NA NA hsa-let-7i-5p INSR 0.0473185312396307 0.869714142234765 -1.82386828224005 0.000371643290248406 miRNATAP -0.277459321096239 0.00829508093625736 NA NA NA hsa-miR-142-5p INSR 3.95552531913424 1.49536283724079e-08 -1.82386828224005 0.000371643290248406 mirMAP -0.161341786682647 7.17193308352054e-05 NA NA NA hsa-miR-15a-5p INSR 2.0535411006904 1.91108976398046e-06 -1.82386828224005 0.000371643290248406 miRNATAP -0.191586455915833 0.00450243714493516 NA NA NA hsa-miR-15b-3p INSR 3.57530146629867 5.89922785773482e-11 -1.82386828224005 0.000371643290248406 mirMAP -0.215002361054263 3.16844858196134e-05 NA NA NA hsa-miR-15b-5p INSR 3.32329949959268 8.40210501034588e-13 -1.82386828224005 0.000371643290248406 miRNATAP -0.171102026127446 0.00506808000233376 NA NA NA hsa-miR-16-5p INSR 2.93575808220754 2.15436817162977e-10 -1.82386828224005 0.000371643290248406 miRNATAP -0.24779172181824 5.54083644186394e-05 NA NA NA hsa-miR-205-5p INSR 8.08298115900323 3.83045179398654e-07 -1.82386828224005 0.000371643290248406 mirMAP -0.169841142195675 1.6939087531646e-24 NA NA NA hsa-miR-27a-3p INSR 1.76094007417453 0.000216137556256765 -1.82386828224005 0.000371643290248406 miRNATAP -0.401729264332008 1.50152175096794e-11 NA NA NA hsa-miR-27b-3p INSR -0.0929089601968123 0.85847352206581 -1.82386828224005 0.000371643290248406 miRNATAP -0.296898999337484 9.42890585090765e-08 NA NA NA hsa-miR-330-3p INSR 2.49094236945806 0.000129367003214715 -1.82386828224005 0.000371643290248406 mirMAP -0.233621942475476 1.08089071418648e-07 NA NA NA hsa-miR-330-5p INSR 2.25110496739954 0.000275527655397415 -1.82386828224005 0.000371643290248406 miRanda -0.213146692117644 4.45542029633152e-06 NA NA NA hsa-miR-342-3p INSR 1.31107714473009 0.0207211910724662 -1.82386828224005 0.000371643290248406 miRanda -0.220858336321934 1.62046279387172e-05 NA NA NA hsa-miR-590-3p INSR 2.35429565068338 2.79601879608564e-06 -1.82386828224005 0.000371643290248406 PITA;miRanda;mirMAP;miRNATAP -0.228068697085361 6.85994082542582e-05 NA NA NA hsa-miR-590-5p INSR 1.51400888103768 0.0023888567923017 -1.82386828224005 0.000371643290248406 mirMAP -0.186179267308814 0.0014962708566854 NA NA NA hsa-miR-16-1-3p IRS1 2.83281226969693 7.54359864580834e-09 -2.42818243639528 0.00335633570259511 MirTarget -0.402423889056367 1.74799716861071e-05 NA NA NA hsa-miR-17-3p IRS1 1.2477858204856 0.00186593270231258 -2.42818243639528 0.00335633570259511 MirTarget -0.33923509585227 0.00419996843488555 NA NA NA hsa-miR-200c-3p IRS1 6.47012025883743 2.64500707716408e-26 -2.42818243639528 0.00335633570259511 miRNATAP -0.327926991247788 3.09985403660766e-06 NA NA NA hsa-miR-30e-5p IRS1 0.780047227271616 0.0346714425913016 -2.42818243639528 0.00335633570259511 MirTarget -0.667408371690413 1.74879102906475e-07 NA NA NA hsa-miR-33b-5p IRS1 4.77891217497671 1.33695107675057e-08 -2.42818243639528 0.00335633570259511 MirTarget -0.169662208897881 0.00197887036814055 NA NA NA hsa-miR-590-3p IRS1 2.35429565068338 2.79601879608564e-06 -2.42818243639528 0.00335633570259511 PITA;miRanda;miRNATAP -0.247231304914087 0.00789279688133779 NA NA NA hsa-miR-616-5p IRS1 2.48416313933027 0.00318247475868827 -2.42818243639528 0.00335633570259511 MirTarget -0.199494797723977 0.00430117559699232 NA NA NA hsa-let-7a-5p ITGA1 0.148081801547773 0.645305441523746 -1.26498040699148 0.088392048220612 TargetScan -0.483504943476011 0.00030509079530284 NA NA NA hsa-miR-141-5p ITGA1 7.13744624551943 4.06877058732583e-26 -1.26498040699148 0.088392048220612 MirTarget -0.285166951724414 4.38162795097281e-07 NA NA NA hsa-miR-200a-5p ITGA1 6.52092140839401 5.73108242597059e-22 -1.26498040699148 0.088392048220612 mirMAP -0.272573796738383 1.93794995761484e-06 NA NA NA hsa-miR-200b-3p ITGA1 5.56167217794639 6.43540045061709e-16 -1.26498040699148 0.088392048220612 MirTarget -0.267889806999112 3.26256500212118e-06 NA NA NA hsa-miR-200b-5p ITGA1 6.81954246537908 6.31100593281326e-24 -1.26498040699148 0.088392048220612 mirMAP -0.270528138511657 2.0265899364053e-06 NA NA NA hsa-miR-200c-3p ITGA1 6.47012025883743 2.64500707716408e-26 -1.26498040699148 0.088392048220612 MirTarget -0.204503030574105 0.00123950956879595 NA NA NA hsa-miR-3065-5p ITGA1 2.14185373842821 0.0609400502269891 -1.26498040699148 0.088392048220612 MirTarget -0.133615366193534 0.0034971392554638 NA NA NA hsa-miR-30e-3p ITGA1 -0.0362193022195196 0.932577027239525 -1.26498040699148 0.088392048220612 MirTarget -0.440155123291204 8.2026443215572e-06 NA NA NA hsa-miR-3607-3p ITGA1 1.38015131722213 0.0240067155694847 -1.26498040699148 0.088392048220612 MirTarget -0.199022837754732 0.00383426843910607 NA NA NA hsa-miR-362-3p ITGA1 0.679952485897744 0.226148468488576 -1.26498040699148 0.088392048220612 miRanda -0.281292921528887 0.000182340568495356 NA NA NA hsa-miR-429 ITGA1 6.39965293994036 1.96920201593608e-18 -1.26498040699148 0.088392048220612 MirTarget;miRanda -0.241033706659753 7.39732065850364e-06 NA NA NA hsa-miR-452-5p ITGA1 2.45466810475361 0.00114794259949532 -1.26498040699148 0.088392048220612 mirMAP -0.203026588882249 0.000229655598988399 NA NA NA hsa-miR-590-3p ITGA1 2.35429565068338 2.79601879608564e-06 -1.26498040699148 0.088392048220612 miRanda;mirMAP -0.235871027783602 0.00447600991029369 NA NA NA hsa-miR-944 ITGA1 7.20925181386398 0.000823207457340648 -1.26498040699148 0.088392048220612 mirMAP -0.132454478391015 2.00221070282753e-08 NA NA NA hsa-miR-15b-5p ITGA10 3.32329949959268 8.40210501034588e-13 -3.0324799051313 0.000349758806116683 MirTarget -0.266817813729584 0.0084426851584161 NA NA NA hsa-miR-16-5p ITGA10 2.93575808220754 2.15436817162977e-10 -3.0324799051313 0.000349758806116683 MirTarget -0.392032945893283 0.000122004852825301 NA NA NA hsa-miR-22-3p ITGA10 0.845430028554782 0.0148923883819448 -3.0324799051313 0.000349758806116683 MirTarget -0.385040477361561 0.00679206845812665 NA NA NA hsa-miR-484 ITGA10 1.79050445056016 0.000217287101253701 -3.0324799051313 0.000349758806116683 miRNATAP -0.310642610565897 0.00186257575299541 NA NA NA hsa-miR-708-5p ITGA10 1.70409736218557 0.0319538709865338 -3.0324799051313 0.000349758806116683 MirTarget -0.237166525853688 8.84844505200035e-05 NA NA NA hsa-miR-429 ITGA11 6.39965293994036 1.96920201593608e-18 -5.26610747645875 5.22517143054214e-06 miRNATAP -0.361076653914883 2.23587180545875e-05 NA NA NA hsa-miR-107 ITGA2 1.49443409571439 0.000130594521065411 2.48937739463293 0.0160407654539565 MirTarget;miRanda;miRNATAP -0.60235086510186 6.08171636894277e-05 NA NA NA hsa-miR-129-5p ITGA2 -2.66843722411409 0.00695783358331245 2.48937739463293 0.0160407654539565 miRanda -0.166845239014 0.00545683203378439 NA NA NA hsa-miR-130b-3p ITGA2 3.9204771543282 1.2714917955808e-11 2.48937739463293 0.0160407654539565 mirMAP -0.26949750894093 0.00618220603286604 NA NA NA hsa-miR-181c-5p ITGA2 -0.302833440762172 0.537532549455539 2.48937739463293 0.0160407654539565 MirTarget -0.498322423732286 3.20866256159181e-05 NA NA NA hsa-miR-181d-5p ITGA2 -0.529098579553155 0.325262124523294 2.48937739463293 0.0160407654539565 MirTarget -0.460006206783873 2.48285148783312e-05 NA NA NA hsa-miR-186-5p ITGA2 0.445443449112564 0.185447310527704 2.48937739463293 0.0160407654539565 mirMAP -0.927691887788398 1.36024992771876e-07 NA NA NA hsa-miR-200b-3p ITGA2 5.56167217794639 6.43540045061709e-16 2.48937739463293 0.0160407654539565 mirMAP -0.300708652888699 0.000201997114046623 NA NA NA hsa-miR-20b-3p ITGA2 3.32857825638616 0.0632388433748268 2.48937739463293 0.0160407654539565 MirTarget -0.370795667992348 4.49651086449395e-11 NA NA NA hsa-miR-301a-3p ITGA2 1.99338115332667 0.000813358604963724 2.48937739463293 0.0160407654539565 mirMAP -0.326299688546253 0.000878198912114417 NA NA NA hsa-miR-30a-5p ITGA2 -0.768430903969183 0.320487552854215 2.48937739463293 0.0160407654539565 miRNAWalker2_validate;mirMAP -0.349994506094588 3.2467603082632e-06 NA NA NA hsa-miR-324-5p ITGA2 1.31253452379847 0.0116806680545163 2.48937739463293 0.0160407654539565 miRanda -0.444704495510645 7.74752785538148e-05 NA NA NA hsa-miR-326 ITGA2 1.76645822596029 0.0367310428720192 2.48937739463293 0.0160407654539565 PITA -0.182648658757677 0.00899805581337897 NA NA NA hsa-miR-335-5p ITGA2 0.167216045757305 0.803897055331049 2.48937739463293 0.0160407654539565 miRNAWalker2_validate -0.36054931089979 3.33306142160341e-05 NA NA NA hsa-miR-362-3p ITGA2 0.679952485897744 0.226148468488576 2.48937739463293 0.0160407654539565 miRanda -0.362980929405073 0.00055693712069407 NA NA NA hsa-miR-429 ITGA2 6.39965293994036 1.96920201593608e-18 2.48937739463293 0.0160407654539565 mirMAP -0.288938497609893 0.000128125948214856 NA NA NA hsa-miR-532-5p ITGA2 -0.297424983759107 0.503934707453099 2.48937739463293 0.0160407654539565 MirTarget -0.852321365536599 5.40124199251107e-11 NA NA NA hsa-miR-7-1-3p ITGA2 1.43074343339835 0.00471215970502094 2.48937739463293 0.0160407654539565 mirMAP -0.372143623171953 0.00135095540108011 NA NA NA hsa-miR-93-3p ITGA2 2.62833115374128 2.28843227834337e-07 2.48937739463293 0.0160407654539565 MirTarget -0.301030896196376 0.00843125839635485 NA NA NA hsa-miR-186-5p ITGA3 0.445443449112564 0.185447310527704 1.15865159896005 0.16326000855788 miRNATAP -0.430483549794558 0.00263739211420173 NA NA NA hsa-miR-199a-5p ITGA3 -1.24888110793613 0.0747755616523728 1.15865159896005 0.16326000855788 MirTarget;PITA;miRanda;miRNATAP -0.311229980709095 2.78988611978246e-06 NA NA NA hsa-miR-199b-5p ITGA3 -0.53728867775768 0.476885702455766 1.15865159896005 0.16326000855788 MirTarget;PITA;miRanda;miRNATAP -0.17412721955362 0.00527929038551849 NA NA NA hsa-miR-28-5p ITGA3 -0.815636722979196 0.0221199948901761 1.15865159896005 0.16326000855788 miRanda -0.398232591860544 0.00302540576464255 NA NA NA hsa-miR-17-5p ITGA4 2.3269271449522 2.13987445663942e-05 -0.1318256530083 0.861915108170382 TargetScan -0.327301717821497 2.14901079032523e-05 NA NA NA hsa-miR-339-5p ITGA4 1.23326828594484 0.0307501214818698 -0.1318256530083 0.861915108170382 miRanda -0.316601955012481 2.21364578749275e-05 NA NA NA hsa-miR-194-3p ITGA5 1.91743783341496 0.105383373371284 -1.8446504207096 0.0297085003383229 miRNATAP -0.167523590044212 3.75406176722769e-05 NA NA NA hsa-miR-25-3p ITGA5 1.12623030168869 0.00311079344417173 -1.8446504207096 0.0297085003383229 miRNATAP -0.420585827540342 0.000980687689145723 NA NA NA hsa-miR-3065-3p ITGA5 1.89496019576082 0.0308154823923145 -1.8446504207096 0.0297085003383229 miRNATAP -0.258701460823073 1.70453975199898e-06 NA NA NA hsa-miR-30d-5p ITGA5 0.302504510257496 0.380193536606962 -1.8446504207096 0.0297085003383229 miRNATAP -0.607621466097398 1.82825815943687e-05 NA NA NA hsa-miR-429 ITGA5 6.39965293994036 1.96920201593608e-18 -1.8446504207096 0.0297085003383229 miRNATAP -0.433082891873838 5.37646123031644e-13 NA NA NA hsa-miR-186-5p ITGA6 0.445443449112564 0.185447310527704 0.383259246590611 0.627235429901036 mirMAP -0.656259573484902 9.92452631559897e-07 NA NA NA hsa-miR-34a-5p ITGA6 0.830377770217786 0.0477544831885907 0.383259246590611 0.627235429901036 miRNAWalker2_validate -0.452006433913939 2.29873658415737e-05 NA NA NA hsa-miR-326 ITGA7 1.76645822596029 0.0367310428720192 -3.9594219043061 7.06152453892692e-08 miRanda -0.154064465991876 0.00227949376467248 NA NA NA hsa-miR-330-5p ITGA7 2.25110496739954 0.000275527655397415 -3.9594219043061 7.06152453892692e-08 miRanda -0.428390514770177 1.15250176569201e-10 NA NA NA hsa-miR-34c-3p ITGA7 4.0411891981675 0.000195495966405666 -3.9594219043061 7.06152453892692e-08 miRNATAP -0.124588712484541 0.00135859971808194 NA NA NA hsa-miR-130a-3p ITGA8 0.176861046122832 0.7577473016872 -4.41883601566347 0.00157102813875894 mirMAP -0.401349991879837 0.0041127974162095 NA NA NA hsa-miR-130b-3p ITGA8 3.9204771543282 1.2714917955808e-11 -4.41883601566347 0.00157102813875894 mirMAP -0.570612285659858 1.63087326339398e-05 NA NA NA hsa-miR-16-1-3p ITGA8 2.83281226969693 7.54359864580834e-09 -4.41883601566347 0.00157102813875894 mirMAP -0.715293104440608 6.16894888523761e-06 NA NA NA hsa-miR-183-5p ITGA8 6.61903249270777 1.00958881445636e-16 -4.41883601566347 0.00157102813875894 miRNAWalker2_validate -0.407003334191852 1.49786712639344e-05 NA NA NA hsa-miR-19b-1-5p ITGA8 1.51335451095424 0.0014717605268143 -4.41883601566347 0.00157102813875894 mirMAP -0.848289856283959 2.95470701733427e-07 NA NA NA hsa-miR-301a-3p ITGA8 1.99338115332667 0.000813358604963724 -4.41883601566347 0.00157102813875894 mirMAP -0.578754131959062 1.20490137068534e-05 NA NA NA hsa-miR-30b-5p ITGA8 0.0238659735605804 0.953223658270319 -4.41883601566347 0.00157102813875894 mirMAP -0.660999710946903 0.000875031638761344 NA NA NA hsa-miR-30c-5p ITGA8 0.38723991118075 0.348605235643473 -4.41883601566347 0.00157102813875894 mirMAP -0.54571897010526 0.00533372184612084 NA NA NA hsa-miR-32-3p ITGA8 2.20477794939766 0.0392771274032852 -4.41883601566347 0.00157102813875894 mirMAP -0.630733264522013 1.17662094757533e-06 NA NA NA hsa-miR-335-3p ITGA8 1.19503568251824 0.0938852560631551 -4.41883601566347 0.00157102813875894 mirMAP -0.496815436916177 7.22869424658285e-06 NA NA NA hsa-miR-33a-5p ITGA8 2.60046838991599 0.000472459723448608 -4.41883601566347 0.00157102813875894 mirMAP -0.491207056465847 3.01408208626793e-06 NA NA NA hsa-miR-454-3p ITGA8 1.40269869979902 0.00366085847011367 -4.41883601566347 0.00157102813875894 mirMAP -0.577992743814308 0.000465859699814926 NA NA NA hsa-miR-590-5p ITGA8 1.51400888103768 0.0023888567923017 -4.41883601566347 0.00157102813875894 mirMAP -0.730230346362338 4.09605312238067e-06 NA NA NA hsa-miR-944 ITGA8 7.20925181386398 0.000823207457340648 -4.41883601566347 0.00157102813875894 mirMAP -0.182106729983324 5.80230737637723e-05 NA NA NA hsa-let-7f-2-3p ITGA9 1.02768112108475 0.0787293499732611 -4.47321269464937 3.75290256398685e-06 mirMAP -0.256273743071828 0.00884819888383793 NA NA NA hsa-miR-141-5p ITGA9 7.13744624551943 4.06877058732583e-26 -4.47321269464937 3.75290256398685e-06 MirTarget -0.514080580998604 2.31475492245911e-12 NA NA NA hsa-miR-200b-3p ITGA9 5.56167217794639 6.43540045061709e-16 -4.47321269464937 3.75290256398685e-06 mirMAP -0.280092408695882 0.000259584904628051 24518294;26334393 β1 integrin inhibition elicits a prometastatic switch through the TGFβ miR 200 ZEB network in E cadherin positive triple negative breast cancer;We revealed that miR-200b suppresses the integrin β1-AKT pathway via targeting Kindlin-2 to mitigate ESCC cell invasiveness ; breast cancer;esophageal cancer hsa-miR-20a-3p ITGA9 1.9920766549842 0.000624458530894697 -4.47321269464937 3.75290256398685e-06 mirMAP -0.247989909371349 0.00928204819459269 NA NA NA hsa-miR-3065-5p ITGA9 2.14185373842821 0.0609400502269891 -4.47321269464937 3.75290256398685e-06 mirMAP -0.243644689828624 5.11484993736736e-05 NA NA NA hsa-miR-330-3p ITGA9 2.49094236945806 0.000129367003214715 -4.47321269464937 3.75290256398685e-06 mirMAP -0.250202590759516 0.00327599226627843 NA NA NA hsa-miR-33a-3p ITGA9 2.06269680799532 0.00156436055383943 -4.47321269464937 3.75290256398685e-06 mirMAP -0.314120879187455 0.000219640524527888 NA NA NA hsa-miR-33a-5p ITGA9 2.60046838991599 0.000472459723448608 -4.47321269464937 3.75290256398685e-06 mirMAP -0.4041620909583 2.96080269679286e-08 NA NA NA hsa-miR-33b-5p ITGA9 4.77891217497671 1.33695107675057e-08 -4.47321269464937 3.75290256398685e-06 mirMAP -0.441799062438306 1.85671322296002e-12 NA NA NA hsa-miR-429 ITGA9 6.39965293994036 1.96920201593608e-18 -4.47321269464937 3.75290256398685e-06 miRanda -0.248446769029797 0.000522742796876246 NA NA NA hsa-miR-452-3p ITGA9 2.97956996345436 0.000203580834647624 -4.47321269464937 3.75290256398685e-06 MirTarget -0.298440822728137 1.25328932422372e-05 NA NA NA hsa-miR-452-5p ITGA9 2.45466810475361 0.00114794259949532 -4.47321269464937 3.75290256398685e-06 mirMAP -0.271101698657981 0.000200371239500677 NA NA NA hsa-miR-590-3p ITGA9 2.35429565068338 2.79601879608564e-06 -4.47321269464937 3.75290256398685e-06 miRanda -0.306178511315388 0.00530429581331429 NA NA NA hsa-miR-141-3p ITGAV 7.30474126597325 1.45115996357606e-24 -0.352039895655465 0.454432205712453 MirTarget -0.100320119594751 0.00348634289909069 NA NA NA hsa-miR-16-2-3p ITGAV 3.79845098071094 1.49120139344659e-13 -0.352039895655465 0.454432205712453 mirMAP -0.14339534840751 0.00402671067495608 NA NA NA hsa-miR-186-5p ITGAV 0.445443449112564 0.185447310527704 -0.352039895655465 0.454432205712453 mirMAP -0.312312632091072 0.000102720591168924 NA NA NA hsa-miR-200a-3p ITGAV 6.336081120041 4.024313571871e-16 -0.352039895655465 0.454432205712453 MirTarget -0.135489080461771 2.53917071546109e-05 NA NA NA hsa-miR-20b-3p ITGAV 3.32857825638616 0.0632388433748268 -0.352039895655465 0.454432205712453 MirTarget -0.100886928603515 0.00010703757543393 NA NA NA hsa-miR-340-5p ITGAV 1.41210478721579 0.00958612942879818 -0.352039895655465 0.454432205712453 MirTarget -0.135365564525711 0.00564845992977706 NA NA NA hsa-miR-363-3p ITGAV 4.27232887548977 8.53979362839458e-06 -0.352039895655465 0.454432205712453 MirTarget -0.108949559747721 5.82239107850678e-05 NA NA NA hsa-miR-429 ITGAV 6.39965293994036 1.96920201593608e-18 -0.352039895655465 0.454432205712453 miRanda -0.127923081922559 0.000178127067563742 NA NA NA hsa-miR-590-3p ITGAV 2.35429565068338 2.79601879608564e-06 -0.352039895655465 0.454432205712453 MirTarget;PITA;miRanda -0.20055477784318 0.000119095540512076 NA NA NA hsa-miR-616-5p ITGAV 2.48416313933027 0.00318247475868827 -0.352039895655465 0.454432205712453 mirMAP -0.160642317931749 3.9832268474519e-05 NA NA NA hsa-miR-16-2-3p ITGB1 3.79845098071094 1.49120139344659e-13 -1.00653525562584 0.0233742054275398 mirMAP -0.127822060458251 0.00679829102276889 NA NA NA hsa-miR-195-3p ITGB1 -2.39100534119332 0.000185405399054065 -1.00653525562584 0.0233742054275398 mirMAP -0.124925043524076 0.00144595463671559 NA NA NA hsa-miR-29c-3p ITGB1 -0.414153610337085 0.529344128062017 -1.00653525562584 0.0233742054275398 MirTarget;miRNATAP -0.181000039570301 1.75141643407349e-06 26766915 MiR 29c inhibits cell growth invasion and migration of pancreatic cancer by targeting ITGB1; Further analysis revealed that ITGB1 is one of the functional target genes of miR-29c and knockdown of ITGB1 inhibited the proliferation migration and invasion of PC cells which was similar to the effects of overexpression of miR-29c pancreatic cancer hsa-miR-3607-3p ITGB1 1.38015131722213 0.0240067155694847 -1.00653525562584 0.0233742054275398 MirTarget -0.181397756406584 8.5867912021978e-06 NA NA NA hsa-miR-429 ITGB1 6.39965293994036 1.96920201593608e-18 -1.00653525562584 0.0233742054275398 miRanda -0.168275635101156 1.38586438823119e-07 NA NA NA hsa-let-7a-5p ITGB3 0.148081801547773 0.645305441523746 -3.67655280362362 0.00223203801274871 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.726886599287972 0.00088047108902417 NA NA NA hsa-let-7b-5p ITGB3 -0.189422992330471 0.651878220048983 -3.67655280362362 0.00223203801274871 MirTarget;miRNATAP -0.466917722728155 0.00482453246097113 NA NA NA hsa-let-7c-5p ITGB3 -2.03831836681378 0.0228401148731997 -3.67655280362362 0.00223203801274871 MirTarget -0.295480032951115 9.7151989404412e-05 23981581 MicroRNA let 7c inhibits migration and invasion of human non small cell lung cancer by targeting ITGB3 and MAP4K3; We then analyzed the potential targets of let-7c and found that ITGB3 and MAP4K3 were directly repressed by let-7c; Collectively our results suggest that let-7c by degrading ITGB3 and MAP4K3 prevents NSCLC metastasis metastasis lung squamous cell cancer hsa-let-7d-5p ITGB3 0.831142050231414 0.0126955498524287 -3.67655280362362 0.00223203801274871 MirTarget -0.631939759107509 0.00257072615968396 NA NA NA hsa-let-7f-5p ITGB3 0.971961126099146 0.0240319857511033 -3.67655280362362 0.00223203801274871 MirTarget;miRNATAP -0.415065991799071 0.00986862803029187 NA NA NA hsa-let-7g-5p ITGB3 0.857251702023746 0.00647597344297273 -3.67655280362362 0.00223203801274871 MirTarget;miRNATAP -0.627271335820792 0.00487356645856055 NA NA NA hsa-miR-221-3p ITGB3 0.94082283577318 0.174749164179978 -3.67655280362362 0.00223203801274871 MirTarget -0.379286409283507 0.00011751707674512 NA NA NA hsa-miR-222-3p ITGB3 1.54730827524553 0.0223014220569407 -3.67655280362362 0.00223203801274871 MirTarget -0.375142007751169 0.000194130386104063 NA NA NA hsa-miR-3607-3p ITGB3 1.38015131722213 0.0240067155694847 -3.67655280362362 0.00223203801274871 MirTarget;mirMAP;miRNATAP -0.399473651029349 0.00035088628883246 NA NA NA hsa-miR-429 ITGB3 6.39965293994036 1.96920201593608e-18 -3.67655280362362 0.00223203801274871 miRanda -0.347218456690496 7.88454627867982e-05 NA NA NA hsa-miR-590-3p ITGB3 2.35429565068338 2.79601879608564e-06 -3.67655280362362 0.00223203801274871 PITA;miRanda -0.580537924410798 1.48574142592059e-05 NA NA NA hsa-miR-409-5p ITGB4 -0.449167445769493 0.560488586390098 1.93236590506635 0.0078541962687005 miRNATAP -0.185348873290168 0.000538428966301777 NA NA NA hsa-miR-532-5p ITGB4 -0.297424983759107 0.503934707453099 1.93236590506635 0.0078541962687005 miRNATAP -0.568150416342564 5.90756876093924e-10 NA NA NA hsa-miR-155-5p ITGB5 2.81443182173772 7.42530504828797e-05 -0.701207879384589 0.203434330470357 miRNAWalker2_validate -0.152875601100387 0.000414745149089452 NA NA NA hsa-miR-484 ITGB5 1.79050445056016 0.000217287101253701 -0.701207879384589 0.203434330470357 miRNATAP -0.302918195738408 1.88093521370537e-06 NA NA NA hsa-miR-126-5p ITGB6 -0.420466581381807 0.329972801718418 6.67143633574658 3.22121277576178e-10 MirTarget -0.415614234841515 0.00425468965815375 NA NA NA hsa-miR-197-3p ITGB6 1.23723883665376 0.0073292027020411 6.67143633574658 3.22121277576178e-10 MirTarget -0.427085806147636 0.00153432226226217 NA NA NA hsa-miR-335-5p ITGB6 0.167216045757305 0.803897055331049 6.67143633574658 3.22121277576178e-10 miRNAWalker2_validate -0.240639219278252 0.00920908071231187 NA NA NA hsa-miR-217 ITGB7 -0.378397407994341 0.717408682071252 2.04930474454161 0.00336569672810882 miRanda -0.116593660775338 0.00228841031323367 NA NA NA hsa-miR-17-5p ITGB8 2.3269271449522 2.13987445663942e-05 1.24386114652931 0.0578765454334701 MirTarget;TargetScan;miRNATAP -0.179908716460646 0.00761978771797361 NA NA NA hsa-miR-181a-5p ITGB8 1.25558293560636 0.00748975499703878 1.24386114652931 0.0578765454334701 miRNATAP -0.27863375760097 0.000441532883488736 NA NA NA hsa-miR-181b-5p ITGB8 1.11397227523501 0.0273417050354018 1.24386114652931 0.0578765454334701 miRNATAP -0.284761950671277 0.000108813261808696 NA NA NA hsa-miR-877-5p ITGB8 3.67317721493893 4.85916829184578e-06 1.24386114652931 0.0578765454334701 MirTarget -0.131559545827072 0.00427842803809181 NA NA NA hsa-miR-106b-5p JAK1 2.80565545918114 1.14547999022566e-09 -0.607027067000509 0.0409054602478455 miRNAWalker2_validate;MirTarget -0.175735146885168 5.72236425533004e-07 NA NA NA hsa-miR-15b-5p JAK1 3.32329949959268 8.40210501034588e-13 -0.607027067000509 0.0409054602478455 miRNAWalker2_validate -0.128316156661929 0.000225441178274573 NA NA NA hsa-miR-17-5p JAK1 2.3269271449522 2.13987445663942e-05 -0.607027067000509 0.0409054602478455 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.143204878903465 1.7592776639734e-06 NA NA NA hsa-miR-20a-5p JAK1 2.13553469875764 0.000181201072324354 -0.607027067000509 0.0409054602478455 MirTarget -0.107022282760873 0.0002295140502555 NA NA NA hsa-miR-30b-5p JAK1 0.0238659735605804 0.953223658270319 -0.607027067000509 0.0409054602478455 MirTarget -0.158824662202472 0.000132583501944976 NA NA NA hsa-miR-93-5p JAK1 2.65964181833033 2.58315947526774e-08 -0.607027067000509 0.0409054602478455 MirTarget;miRNATAP -0.178160799629543 1.56601979979517e-07 NA NA NA hsa-miR-181b-5p JAK2 1.11397227523501 0.0273417050354018 -0.336326790557259 0.592787818955037 mirMAP -0.192618204419721 0.00651043610634605 NA NA NA hsa-miR-335-5p JAK2 0.167216045757305 0.803897055331049 -0.336326790557259 0.592787818955037 miRNAWalker2_validate -0.209615118003146 6.79293979136461e-05 NA NA NA hsa-miR-130a-5p KDR 1.58028512890005 0.024346333013728 -3.78753480302955 5.10405108636238e-08 mirMAP -0.165311550111567 0.00459402915226011 NA NA NA hsa-miR-149-5p KDR 1.18551753240939 0.197439607622379 -3.78753480302955 5.10405108636238e-08 miRNATAP -0.16823133416391 0.000108425090785733 NA NA NA hsa-miR-15a-5p KDR 2.0535411006904 1.91108976398046e-06 -3.78753480302955 5.10405108636238e-08 miRNATAP -0.339778633619659 0.000238480183582385 NA NA NA hsa-miR-15b-5p KDR 3.32329949959268 8.40210501034588e-13 -3.78753480302955 5.10405108636238e-08 miRNATAP -0.444129453078938 7.74379928112357e-08 NA NA NA hsa-miR-16-5p KDR 2.93575808220754 2.15436817162977e-10 -3.78753480302955 5.10405108636238e-08 miRTarBase;miRNATAP -0.48851016538085 4.74935391231666e-09 26934556 The expression levels of two target genes Myb and VEGFR2 were affected significantly by miR-16 while glucose administration inhibited miR-16 expression and enhanced tumor cell proliferation and migration; Hyperglycemia can impact the clinical outcomes of CRC patients likely by inhibiting miR-16 expression and the expression of its downstream genes Myb and VEGFR2 colorectal cancer hsa-miR-19b-1-5p KDR 1.51335451095424 0.0014717605268143 -3.78753480302955 5.10405108636238e-08 miRNAWalker2_validate -0.374119047842397 8.36263028884247e-06 NA NA NA hsa-miR-200b-3p KDR 5.56167217794639 6.43540045061709e-16 -3.78753480302955 5.10405108636238e-08 miRNAWalker2_validate;miRTarBase;TargetScan -0.288850718690057 1.3620986353193e-07 NA NA NA hsa-miR-200c-3p KDR 6.47012025883743 2.64500707716408e-26 -3.78753480302955 5.10405108636238e-08 miRNATAP -0.382297274517525 9.67613306032587e-11 24205206 MiR 200c increases the radiosensitivity of non small cell lung cancer cell line A549 by targeting VEGF VEGFR2 pathway; MiR-200c at the nexus of epithelial-mesenchymal transition EMT is predicted to target VEGFR2; The purpose of this study is to test the hypothesis that regulation of VEGFR2 pathway by miR-200c could modulate the radiosensitivity of cancer cells; Bioinformatic analysis luciferase reporter assays and biochemical assays were carried out to validate VEGFR2 as a direct target of miR-200c; We identified VEGFR2 as a novel target of miR-200c lung squamous cell cancer hsa-miR-3065-3p KDR 1.89496019576082 0.0308154823923145 -3.78753480302955 5.10405108636238e-08 miRNATAP -0.152522999657685 0.000823693140368022 NA NA NA hsa-miR-429 KDR 6.39965293994036 1.96920201593608e-18 -3.78753480302955 5.10405108636238e-08 PITA;miRanda;miRNATAP -0.254695751307412 6.75345335627532e-07 NA NA NA hsa-miR-590-3p KDR 2.35429565068338 2.79601879608564e-06 -3.78753480302955 5.10405108636238e-08 miRanda -0.291216957635586 0.000229202212262984 NA NA NA hsa-miR-590-5p KDR 1.51400888103768 0.0023888567923017 -3.78753480302955 5.10405108636238e-08 miRanda -0.22709962747644 0.00499210436033993 NA NA NA hsa-let-7a-3p KIT 0.82512001802525 0.0468122405194487 -2.92672645158867 0.0121059106239177 mirMAP -0.456483459574477 0.00476283375280992 NA NA NA hsa-let-7b-3p KIT 0.589364128513318 0.200507534602851 -2.92672645158867 0.0121059106239177 mirMAP -0.456223113118345 0.00169406655722655 NA NA NA hsa-let-7f-1-3p KIT 1.61507869803314 0.00069342464777815 -2.92672645158867 0.0121059106239177 mirMAP -0.698593802864777 4.29141574094558e-07 NA NA NA hsa-miR-130b-3p KIT 3.9204771543282 1.2714917955808e-11 -2.92672645158867 0.0121059106239177 miRNATAP -0.326462819564692 0.00327548233370023 NA NA NA hsa-miR-193a-3p KIT 0.646392169474854 0.207134343676122 -2.92672645158867 0.0121059106239177 MirTarget;PITA;miRanda;miRNATAP -0.628369799835687 1.05582859657025e-06 NA NA NA hsa-miR-193b-3p KIT 1.35015762547152 0.0874921379319504 -2.92672645158867 0.0121059106239177 MirTarget;miRNATAP -0.536200449875377 4.8118586153776e-11 NA NA NA hsa-miR-205-5p KIT 8.08298115900323 3.83045179398654e-07 -2.92672645158867 0.0121059106239177 miRNATAP -0.14013386174404 0.00055597213198089 NA NA NA hsa-miR-221-3p KIT 0.94082283577318 0.174749164179978 -2.92672645158867 0.0121059106239177 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.468184353399042 7.36634732718355e-07 NA NA NA hsa-miR-222-3p KIT 1.54730827524553 0.0223014220569407 -2.92672645158867 0.0121059106239177 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.476878413175856 7.92502510891803e-07 NA NA NA hsa-miR-421 KIT 1.97624148591545 0.000915838012451138 -2.92672645158867 0.0121059106239177 miRanda -0.342044279486533 0.00207985864262564 NA NA NA hsa-miR-505-3p KIT 0.58881333170866 0.226937454637888 -2.92672645158867 0.0121059106239177 MirTarget;miRNATAP -0.411216941064139 0.00272393634823858 NA NA NA hsa-miR-590-3p KIT 2.35429565068338 2.79601879608564e-06 -2.92672645158867 0.0121059106239177 miRanda;mirMAP -0.376962857517699 0.00395564823221356 NA NA NA hsa-miR-671-5p KIT 1.48527046124636 0.00686722328347111 -2.92672645158867 0.0121059106239177 MirTarget -0.344859718087955 0.00431717487584727 NA NA NA hsa-miR-186-5p KITLG 0.445443449112564 0.185447310527704 -0.327105687275833 0.647770640579017 mirMAP -0.466116355671567 0.000143165016740803 NA NA NA hsa-miR-30e-5p KITLG 0.780047227271616 0.0346714425913016 -0.327105687275833 0.647770640579017 mirMAP -0.602413763455738 3.69850705900767e-08 NA NA NA hsa-miR-34a-5p KITLG 0.830377770217786 0.0477544831885907 -0.327105687275833 0.647770640579017 MirTarget -0.351407580248374 0.000300576820974917 NA NA NA hsa-miR-590-3p KRAS 2.35429565068338 2.79601879608564e-06 0.397475629872277 0.267914845700271 PITA;miRanda;mirMAP -0.104783145997534 0.00867065435764531 NA NA NA hsa-miR-590-3p LAMA2 2.35429565068338 2.79601879608564e-06 -3.53377008507832 0.000436975489007485 miRanda -0.373683396051962 0.000941436286040134 NA NA NA hsa-miR-21-5p LAMA4 2.65163477806992 6.72089787690756e-16 -3.56149879705325 1.27923401133307e-06 MirTarget -0.341718185439046 0.00650238283200569 NA NA NA hsa-miR-32-3p LAMA4 2.20477794939766 0.0392771274032852 -3.56149879705325 1.27923401133307e-06 MirTarget -0.184420820478315 0.00833220853048297 NA NA NA hsa-miR-429 LAMA4 6.39965293994036 1.96920201593608e-18 -3.56149879705325 1.27923401133307e-06 miRanda -0.317305661958497 3.03194566663184e-09 NA NA NA hsa-miR-590-3p LAMA4 2.35429565068338 2.79601879608564e-06 -3.56149879705325 1.27923401133307e-06 miRanda -0.296389195119431 0.000371133333682864 NA NA NA hsa-miR-93-3p LAMA4 2.62833115374128 2.28843227834337e-07 -3.56149879705325 1.27923401133307e-06 miRNAWalker2_validate -0.232390621474218 0.00476445985234956 NA NA NA hsa-miR-142-3p LAMB1 4.35304505457969 3.10014573651358e-10 -1.19379389325748 0.082411720148995 miRanda -0.247056299117126 5.04988257537278e-06 NA NA NA hsa-miR-16-5p LAMB1 2.93575808220754 2.15436817162977e-10 -1.19379389325748 0.082411720148995 miRNAWalker2_validate -0.309530004921581 0.000161101673218644 NA NA NA hsa-miR-218-5p LAMB3 -1.62589026509455 0.0400573414088521 5.31033984551687 1.89458396750723e-07 miRNAWalker2_validate;miRTarBase -0.260734962265846 0.000427167802166377 20163849;23320911;17998940;25337271;23159910 Polymorphisms involved in the miR 218 LAMB3 pathway and susceptibility of cervical cancer a case control study in Chinese women; MicroRNA-218 miR-218 can target laminin-5 beta3 LAMB3 but suppressed by HPV-16 E6 protein;However this association was not observed for the miR-218 binding site SNP rs2566 on LAMB3;We also demonstrate that the epithelial cell-specific marker LAMB3 is a target of miR-218; We also show that LAMB3 expression is increased in the presence of the HPV-16 E6 oncogene and this effect is mediated through miR-218;The aim of this study was to investigate whether polymorphisms in miR-218 LAMB3 pathway were associated with the risk and prognosis of esophageal squamous cell carcinoma ESCC;Furthermore we focused on LAMB3 which has a miR-218 target site and gene expression studies and luciferase reporter assays showed that LAMB3 was directly regulated by miR-218 ;;;worse prognosis; cervical and endocervical cancer;cervical and endocervical cancer;cervical and endocervical cancer;esophageal cancer;head and neck cancer hsa-miR-146b-5p LAMC1 1.87569569182453 0.000737241069698886 -1.1345245467724 0.0487516321194313 miRanda -0.16146934050627 0.00583795734888103 NA NA NA hsa-miR-15a-5p LAMC1 2.0535411006904 1.91108976398046e-06 -1.1345245467724 0.0487516321194313 MirTarget -0.233643526162451 0.00188489189895224 NA NA NA hsa-miR-200b-3p LAMC1 5.56167217794639 6.43540045061709e-16 -1.1345245467724 0.0487516321194313 MirTarget;TargetScan -0.168074713864644 0.000182531647838776 NA NA NA hsa-miR-29c-3p LAMC1 -0.414153610337085 0.529344128062017 -1.1345245467724 0.0487516321194313 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.149575116389429 0.00260104788351692 NA NA NA hsa-miR-362-3p LAMC1 0.679952485897744 0.226148468488576 -1.1345245467724 0.0487516321194313 miRanda -0.15670901878609 0.00750072807430818 NA NA NA hsa-miR-452-5p LAMC1 2.45466810475361 0.00114794259949532 -1.1345245467724 0.0487516321194313 MirTarget -0.123251751639601 0.00408263503279682 NA NA NA hsa-miR-642a-5p LAMC1 3.38585273752088 0.000272015814573312 -1.1345245467724 0.0487516321194313 MirTarget -0.168505635479068 8.73035461122514e-05 NA NA NA hsa-miR-942-5p LAMC1 3.36242661558642 1.89848306955335e-10 -1.1345245467724 0.0487516321194313 MirTarget -0.175812717092046 0.00351903554877274 NA NA NA hsa-miR-660-5p LAMC2 -0.0668683798854808 0.885250178390404 4.53104586077785 3.72443772943175e-05 MirTarget -0.72103092680186 9.88253636768622e-08 NA NA NA hsa-miR-16-2-3p LPAR1 3.79845098071094 1.49120139344659e-13 -1.62906252916246 0.0315547424243455 MirTarget;mirMAP -0.298596553303424 0.000201544492972082 NA NA NA hsa-miR-20a-3p LPAR1 1.9920766549842 0.000624458530894697 -1.62906252916246 0.0315547424243455 MirTarget -0.284778221992615 9.8722771895049e-05 NA NA NA hsa-miR-335-3p LPAR1 1.19503568251824 0.0938852560631551 -1.62906252916246 0.0315547424243455 mirMAP -0.202187115873226 0.000773724709989234 NA NA NA hsa-miR-342-3p LPAR1 1.31107714473009 0.0207211910724662 -1.62906252916246 0.0315547424243455 miRanda -0.251969493770752 0.000889967761917215 NA NA NA hsa-miR-576-5p LPAR1 1.30320223793746 0.00648929463912994 -1.62906252916246 0.0315547424243455 mirMAP -0.243384493690298 0.0070024358110327 NA NA NA hsa-miR-200a-3p LPAR3 6.336081120041 4.024313571871e-16 3.94326410834374 0.00823543381963949 MirTarget -0.286868642990698 0.00566382009527753 NA NA NA hsa-miR-186-5p LPAR5 0.445443449112564 0.185447310527704 3.07262062692522 2.12177870629428e-05 MirTarget -0.635811119182748 3.1693572060119e-07 NA NA NA hsa-miR-874-3p LPAR5 0.137032253927448 0.814724553163592 3.07262062692522 2.12177870629428e-05 MirTarget -0.191952760104525 0.00712981454840879 NA NA NA hsa-miR-101-3p MAP2K1 -1.12421603598195 0.0200907284788457 0.519316108483181 0.113764633840027 miRNAWalker2_validate -0.210296378296097 2.59354101164885e-08 NA NA NA hsa-miR-140-3p MAP2K1 -1.9828800596692 8.92876132959514e-08 0.519316108483181 0.113764633840027 PITA -0.134317183064192 0.00692981390628658 NA NA NA hsa-miR-497-5p MAP2K1 -1.44150596209372 0.0225146607606395 0.519316108483181 0.113764633840027 miRNAWalker2_validate -0.157096186222573 4.82243556573134e-08 NA NA NA hsa-miR-148b-3p MAPK1 1.75622244535669 8.84414356040579e-08 0.0128019530419543 0.96439785606773 mirMAP -0.139901367015828 0.00442278516722453 NA NA NA hsa-miR-29b-2-5p MAPK1 -0.596051745078872 0.189540844841389 0.0128019530419543 0.96439785606773 mirMAP -0.150888486209755 2.15475742904008e-05 NA NA NA hsa-miR-29c-3p MAPK1 -0.414153610337085 0.529344128062017 0.0128019530419543 0.96439785606773 mirMAP -0.121961986993 4.61168241690927e-07 NA NA NA hsa-miR-30b-5p MAPK1 0.0238659735605804 0.953223658270319 0.0128019530419543 0.96439785606773 mirMAP -0.107494044816223 0.00753809874561411 NA NA NA hsa-miR-30e-5p MAPK1 0.780047227271616 0.0346714425913016 0.0128019530419543 0.96439785606773 mirMAP -0.116090988644527 0.00885887810727849 NA NA NA hsa-miR-3913-5p MAPK1 0.145645056779437 0.734844256690741 0.0128019530419543 0.96439785606773 mirMAP -0.108088444698366 0.00439552964093496 NA NA NA hsa-miR-106a-5p MCL1 3.98693608217557 9.37722470816656e-07 0.141019406304951 0.704491791982446 MirTarget;miRNATAP -0.128664303150835 2.43476410686883e-07 23904379 MiR 106a targets Mcl 1 to suppress cisplatin resistance of ovarian cancer A2780 cells; Real-time PCR Western blotting and luciferase reporter assay were applied to explore whether Mcl-1 was a target of miR-106a; Furthermore miR-106a inhibited cell survival and cisplatin resistance through downregulating the expression of Mcl-1; Mcl-1 was a direct target of miR-106a; These results suggest that miR-106a may provide a novel mechanism for understanding cisplatin resistance in ovarian cancer by modulating Mcl-1 drug resistance;poor survival ovarian cancer hsa-miR-106b-5p MCL1 2.80565545918114 1.14547999022566e-09 0.141019406304951 0.704491791982446 MirTarget;miRNATAP -0.135613391231181 0.0023369579481254 NA NA NA hsa-miR-125a-5p MCL1 -1.32352790615388 0.00714301627309467 0.141019406304951 0.704491791982446 MirTarget;PITA;miRanda -0.15989552859433 0.000169289807594193 NA NA NA hsa-miR-186-5p MCL1 0.445443449112564 0.185447310527704 0.141019406304951 0.704491791982446 miRNAWalker2_validate;mirMAP -0.170492643388603 0.00753129360314225 NA NA NA hsa-miR-361-5p MCL1 0.00649167180664723 0.985202350239079 0.141019406304951 0.704491791982446 miRanda -0.217822952829833 0.00035505940403415 NA NA NA hsa-miR-93-5p MCL1 2.65964181833033 2.58315947526774e-08 0.141019406304951 0.704491791982446 MirTarget;miRNATAP -0.145351699831229 0.000740730192511739 NA NA NA hsa-miR-140-5p MDM2 -0.634610285725923 0.126670572966239 1.10063403547143 0.00277879157924784 miRanda -0.133991561849076 0.00853809577209546 NA NA NA hsa-miR-26b-5p MDM2 0.314414148564179 0.461628303578321 1.10063403547143 0.00277879157924784 miRNAWalker2_validate -0.167905763917418 0.00067658693094048 NA NA NA hsa-miR-374b-5p MDM2 -0.114749866169918 0.764888930049438 1.10063403547143 0.00277879157924784 mirMAP -0.202257195528026 0.000245802806142865 NA NA NA hsa-miR-450a-5p MDM2 0.279271977544647 0.642367882565951 1.10063403547143 0.00277879157924784 mirMAP -0.105188175118483 0.00254474898275964 NA NA NA hsa-miR-23b-3p MET -0.581135273821923 0.190478897170459 1.26281304683369 0.0681295111401499 miRNAWalker2_validate;miRTarBase -0.362845153174282 4.35581067718961e-05 19490101 MicroRNA 23b mediates urokinase and c met downmodulation and a decreased migration of human hepatocellular carcinoma cells; In the present study to understand whether the expression of these genes might be coregulated by specific microRNAs miRs in human cells we predicted that Homo sapiens microRNA-23b could recognize two sites in the 3'-UTR of uPA and four sites in the c-met 3'-UTR by the algorithm pictar; The evidence obtained shows that overexpression of miR-23b leads to uPA and c-met downregulation and to decreased migration and proliferation abilities of HCC cells liver cancer hsa-miR-155-5p MYB 2.81443182173772 7.42530504828797e-05 3.76082327769441 1.86886438439304e-05 miRNAWalker2_validate;miRTarBase;miRNATAP -0.191408205912457 0.00649909322422782 NA NA NA hsa-miR-193a-3p MYB 0.646392169474854 0.207134343676122 3.76082327769441 1.86886438439304e-05 miRanda -0.36666236730359 0.00020269440733841 NA NA NA hsa-miR-193b-3p MYB 1.35015762547152 0.0874921379319504 3.76082327769441 1.86886438439304e-05 miRNAWalker2_validate -0.40612490104837 5.77471544798278e-11 NA NA NA hsa-miR-424-5p MYB 0.209571188331903 0.753714747345068 3.76082327769441 1.86886438439304e-05 miRNAWalker2_validate;miRTarBase;miRNATAP -0.210417958048663 0.0054936104775727 24675898 MicroRNA 424 is down regulated in hepatocellular carcinoma and suppresses cell migration and invasion through c Myb; In addition we further identified c-Myb as a functional downstream target of miR-424 by directly targeting the 3'UTR of c-Myb; Our results demonstrated that miR-424 was involved in tumorigenesis of HCC at least in part by suppression of c-Myb cell migration;tumorigenesis liver cancer hsa-miR-455-5p MYB -0.317715589860275 0.616296031007863 3.76082327769441 1.86886438439304e-05 miRanda -0.460950332552555 3.7045163252528e-09 NA NA NA hsa-miR-34a-5p MYC 0.830377770217786 0.0477544831885907 -0.745260197790044 0.453852120838847 miRNAWalker2_validate;miRTarBase -0.427487830189717 0.00161403194033986 25572695;25686834;21460242;22159222;23640973;22830357;22235332 The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;miR 34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c Myc pathway;Myc mediated repression of microRNA 34a promotes high grade transformation of B cell lymphoma by dysregulation of FoxP1;MicroRNA 34a suppresses malignant transformation by targeting c Myc transcriptional complexes in human renal cell carcinoma; We investigated the functional effects of microRNA-34a miR-34a on c-Myc transcriptional complexes in renal cell carcinoma; miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region which was revealed by luciferase reporter assays; Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription indicating a novel role of miR-34a in the regulation of transcription by c-Myc;Among them miR-34a was also associated with poor prognosis in 2 independent series of leukemic and nodal MCL and in cooperation with high expression of the MYC oncogene;We report that miR-34a did not inhibit cell proliferation notwithstanding a marked down-regulation of c-MYC;MicroRNA 34a modulates c Myc transcriptional complexes to suppress malignancy in human prostate cancer cells; We studied the functional effects of miR-34a on c-Myc transcriptional complexes in PC-3 prostate cancer cells; miR-34a downregulated expression of c-Myc oncogene by targeting its 3' UTR as shown by luciferase reporter assays; This is the first report to document that miR-34a suppresses assembly and function of the c-Myc-Skp2-Miz1 complex that activates RhoA and the c-Myc-pTEFB complex that elongates transcription of various genes suggesting a novel role of miR-34a in the regulation of transcription by c-Myc complex ;;;malignant trasformation;worse prognosis;; bladder cancer;liver cancer;B cell lymphoma;kidney renal cell cancer;lymphoma;lymphoma;prostate cancer hsa-miR-429 MYC 6.39965293994036 1.96920201593608e-18 -0.745260197790044 0.453852120838847 miRNAWalker2_validate -0.351232938868747 9.84375821791447e-07 21684154;24633485 miR 429 modulates the expression of c myc in human gastric carcinoma cells; SGC-7901 gastric cancer cells were transfected with miR-429 mimics and endogenous c-myc expression was detected by western blots; We performed functional assays using the 3'UTR of the c-myc gene as a miR-429 target in a luciferase reporter assay system; miR-429 significantly downregulated endogenous c-myc expression in SGC-7901 cells; Action of miR/429 on c-myc 3'UTR was confirmed; c-myc is an important miR-429 target gene;It is known that miR-429 is down-regulated and functions as a tumor suppressor by targeting c-myc and PLGG1 in gastric and breast cancer ; gastric cancer;sarcoma hsa-let-7g-5p NGF 0.857251702023746 0.00647597344297273 -4.9479894848305 8.79599085267218e-05 MirTarget -0.75463687244667 0.00128893578106286 NA NA NA hsa-miR-429 NGF 6.39965293994036 1.96920201593608e-18 -4.9479894848305 8.79599085267218e-05 miRanda -0.370250673166168 6.50680322666926e-05 NA NA NA hsa-miR-194-3p NGFR 1.91743783341496 0.105383373371284 -0.951971591253912 0.547649434951756 mirMAP -0.454214598997743 1.02226572658335e-09 NA NA NA hsa-miR-34a-5p NGFR 0.830377770217786 0.0477544831885907 -0.951971591253912 0.547649434951756 mirMAP -0.866693117394221 5.40136976397098e-05 NA NA NA hsa-miR-429 NOS3 6.39965293994036 1.96920201593608e-18 -3.30827050659288 3.0952635386158e-07 miRanda -0.182524428897628 0.000139300055725838 NA NA NA hsa-miR-26a-5p NRAS -0.352368463397074 0.362040749917446 1.25753065997981 5.62664778753041e-06 mirMAP;miRNATAP -0.172024479324 3.07852593374564e-05 26458859 MiR 26a enhances the sensitivity of gastric cancer cells to cisplatin by targeting NRAS and E2F2; Our results suggest that miR-26a can improve the sensitivity of GC cells to cisplatin-based chemotherapies through targeting NRAS and E2F2 and provide the first evidence of the potential utility of miR-26a as a sensitizer in chemotherapy for GC gastric cancer hsa-miR-28-5p NRAS -0.815636722979196 0.0221199948901761 1.25753065997981 5.62664778753041e-06 MirTarget;PITA;miRanda;miRNATAP -0.124303692945862 0.00588536888643892 NA NA NA hsa-miR-29c-3p NRAS -0.414153610337085 0.529344128062017 1.25753065997981 5.62664778753041e-06 miRNATAP -0.10862780456693 5.17574009803184e-06 NA NA NA hsa-miR-142-3p NTF3 4.35304505457969 3.10014573651358e-10 -3.48574436830551 0.00527602357381811 miRanda -0.264810182718392 0.00811224611096561 NA NA NA hsa-miR-21-5p NTF3 2.65163477806992 6.72089787690756e-16 -3.48574436830551 0.00527602357381811 miRTarBase;miRNATAP -0.72373377555354 0.000571440631212767 NA NA NA hsa-miR-107 NTRK2 1.49443409571439 0.000130594521065411 -1.54248853110693 0.400878993948488 PITA;miRanda -0.821688168341512 0.00210977706630013 NA NA NA hsa-miR-146b-5p NTRK2 1.87569569182453 0.000737241069698886 -1.54248853110693 0.400878993948488 PITA;miRanda -0.611776303657384 0.00101815416167714 NA NA NA hsa-miR-151a-5p NTRK2 1.0755926560327 0.00684662665520532 -1.54248853110693 0.400878993948488 miRNATAP -0.710685927254188 0.00718867606832889 NA NA NA hsa-miR-17-3p NTRK2 1.2477858204856 0.00186593270231258 -1.54248853110693 0.400878993948488 miRNATAP -1.0900436041431 2.63740736557872e-05 NA NA NA hsa-miR-200c-3p NTRK2 6.47012025883743 2.64500707716408e-26 -1.54248853110693 0.400878993948488 miRNAWalker2_validate;miRTarBase -0.454168801324507 0.00376453070732347 23209748;23074172 miR 200c sensitizes breast cancer cells to doxorubicin treatment by decreasing TrkB and Bmi1 expression;miR-200c also targets TrkB a mediator of resistance to anoikis ;drug resistance breast cancer;ovarian cancer hsa-miR-20a-3p NTRK2 1.9920766549842 0.000624458530894697 -1.54248853110693 0.400878993948488 mirMAP -0.54333551336232 0.00222970138095554 NA NA NA hsa-miR-3065-5p NTRK2 2.14185373842821 0.0609400502269891 -1.54248853110693 0.400878993948488 mirMAP -0.352023117959863 0.00183358469630041 NA NA NA hsa-miR-330-5p NTRK2 2.25110496739954 0.000275527655397415 -1.54248853110693 0.400878993948488 miRanda -0.525186837915093 0.00163346148640802 NA NA NA hsa-miR-335-3p NTRK2 1.19503568251824 0.0938852560631551 -1.54248853110693 0.400878993948488 mirMAP -0.787346785860579 3.85050756216982e-08 NA NA NA hsa-miR-338-3p NTRK2 0.447551118940466 0.558485097370031 -1.54248853110693 0.400878993948488 miRanda -0.558724956749295 3.55822561549528e-05 NA NA NA hsa-miR-196b-5p OSMR -0.103579538052452 0.859017000109845 0.550487651528275 0.505425947189116 miRNATAP -0.223545467125938 0.00558557810621312 NA NA NA hsa-miR-200b-3p OSMR 5.56167217794639 6.43540045061709e-16 0.550487651528275 0.505425947189116 TargetScan -0.304673120822428 1.88108458680799e-06 NA NA NA hsa-miR-362-3p OSMR 0.679952485897744 0.226148468488576 0.550487651528275 0.505425947189116 miRanda -0.316285955291011 0.000152555758070928 NA NA NA hsa-miR-429 OSMR 6.39965293994036 1.96920201593608e-18 0.550487651528275 0.505425947189116 miRanda;miRNATAP -0.26582134520331 8.74964941476044e-06 NA NA NA hsa-let-7g-5p PDGFB 0.857251702023746 0.00647597344297273 -1.35839055150716 0.0368647114422999 miRNATAP -0.402727711541148 0.000761785243186828 NA NA NA hsa-miR-29c-3p PDGFB -0.414153610337085 0.529344128062017 -1.35839055150716 0.0368647114422999 MirTarget;miRNATAP -0.222189266753565 7.03118101802513e-05 NA NA NA hsa-miR-342-3p PDGFB 1.31107714473009 0.0207211910724662 -1.35839055150716 0.0368647114422999 miRanda -0.234714756585261 0.000303525547934106 NA NA NA hsa-miR-142-5p PDGFC 3.95552531913424 1.49536283724079e-08 -2.91070060951748 0.00139000090164696 PITA -0.412038941957565 7.05190420357634e-09 NA NA NA hsa-miR-16-2-3p PDGFC 3.79845098071094 1.49120139344659e-13 -2.91070060951748 0.00139000090164696 mirMAP -0.465773453969177 1.30624338512295e-06 NA NA NA hsa-miR-590-3p PDGFC 2.35429565068338 2.79601879608564e-06 -2.91070060951748 0.00139000090164696 PITA;miRanda;mirMAP -0.351545357543993 0.000575533480969303 NA NA NA hsa-miR-7-5p PDGFC 3.59831747997243 0.000676336260217879 -2.91070060951748 0.00139000090164696 miRNAWalker2_validate -0.189597059379568 0.00155972650972824 NA NA NA hsa-miR-944 PDGFC 7.20925181386398 0.000823207457340648 -2.91070060951748 0.00139000090164696 mirMAP -0.26108425269344 7.31299221731432e-21 NA NA NA hsa-miR-19b-1-5p PDGFD 1.51335451095424 0.0014717605268143 -3.47672449807147 2.67668711091569e-05 MirTarget -0.555059079325078 1.53069249384473e-08 NA NA NA hsa-miR-203a-3p PDGFD 6.35084246337388 7.89944323347948e-08 -3.47672449807147 2.67668711091569e-05 MirTarget -0.210887321797665 4.29035196676396e-08 NA NA NA hsa-miR-21-5p PDGFD 2.65163477806992 6.72089787690756e-16 -3.47672449807147 2.67668711091569e-05 miRNAWalker2_validate -0.428672753870124 0.00228532529446352 NA NA NA hsa-miR-330-3p PDGFD 2.49094236945806 0.000129367003214715 -3.47672449807147 2.67668711091569e-05 MirTarget;PITA -0.322795857813532 7.17640468382225e-06 NA NA NA hsa-miR-331-5p PDGFD 1.02712086964089 0.0262526092356277 -3.47672449807147 2.67668711091569e-05 MirTarget -0.50459452120889 7.82329605931321e-07 NA NA NA hsa-miR-590-3p PDGFD 2.35429565068338 2.79601879608564e-06 -3.47672449807147 2.67668711091569e-05 miRanda;mirMAP;miRNATAP -0.485920723947005 1.35839517915101e-07 NA NA NA hsa-miR-590-5p PDGFD 1.51400888103768 0.0023888567923017 -3.47672449807147 2.67668711091569e-05 miRanda -0.502746889245452 8.45090856444761e-08 NA NA NA hsa-miR-7-1-3p PDGFD 1.43074343339835 0.00471215970502094 -3.47672449807147 2.67668711091569e-05 mirMAP -0.299186449027535 0.00143440156627786 NA NA NA hsa-miR-944 PDGFD 7.20925181386398 0.000823207457340648 -3.47672449807147 2.67668711091569e-05 MirTarget;mirMAP -0.152505671774364 1.00392140440174e-08 NA NA NA hsa-let-7a-3p PDGFRA 0.82512001802525 0.0468122405194487 -4.31615823709194 9.59580352063599e-06 mirMAP -0.431928097339744 0.00154173231192395 NA NA NA hsa-let-7f-1-3p PDGFRA 1.61507869803314 0.00069342464777815 -4.31615823709194 9.59580352063599e-06 mirMAP -0.666035412623016 9.51126490432519e-09 NA NA NA hsa-let-7g-3p PDGFRA 2.09736290930341 5.30067796437833e-05 -4.31615823709194 9.59580352063599e-06 MirTarget;miRNATAP -0.385141069458271 0.000319714461007372 NA NA NA hsa-miR-106a-5p PDGFRA 3.98693608217557 9.37722470816656e-07 -4.31615823709194 9.59580352063599e-06 MirTarget;miRNATAP -0.25960492629279 0.000115073753407648 NA NA NA hsa-miR-106b-5p PDGFRA 2.80565545918114 1.14547999022566e-09 -4.31615823709194 9.59580352063599e-06 MirTarget;miRNATAP -0.783177330311627 1.33145452797817e-11 NA NA NA hsa-miR-130b-3p PDGFRA 3.9204771543282 1.2714917955808e-11 -4.31615823709194 9.59580352063599e-06 MirTarget;miRNATAP -0.427321315908455 4.17207041632257e-06 NA NA NA hsa-miR-141-3p PDGFRA 7.30474126597325 1.45115996357606e-24 -4.31615823709194 9.59580352063599e-06 MirTarget -0.459303779088419 7.19932671476961e-11 NA NA NA hsa-miR-16-1-3p PDGFRA 2.83281226969693 7.54359864580834e-09 -4.31615823709194 9.59580352063599e-06 MirTarget -0.700660080272716 1.49692189146508e-10 NA NA NA hsa-miR-17-5p PDGFRA 2.3269271449522 2.13987445663942e-05 -4.31615823709194 9.59580352063599e-06 MirTarget;TargetScan;miRNATAP -0.640106894332429 9.36070480923555e-11 NA NA NA hsa-miR-182-5p PDGFRA 5.86988712704738 1.22411588571584e-15 -4.31615823709194 9.59580352063599e-06 miRNATAP -0.317289848753412 1.07869714551322e-05 NA NA NA hsa-miR-193a-3p PDGFRA 0.646392169474854 0.207134343676122 -4.31615823709194 9.59580352063599e-06 miRanda -0.504497245228834 3.66276149701725e-06 NA NA NA hsa-miR-196a-5p PDGFRA 2.71653705877687 0.0233843546205134 -4.31615823709194 9.59580352063599e-06 MirTarget;miRNATAP -0.15397255400863 0.000904257469932413 NA NA NA hsa-miR-200a-3p PDGFRA 6.336081120041 4.024313571871e-16 -4.31615823709194 9.59580352063599e-06 MirTarget -0.2276447486551 0.000847664710398646 NA NA NA hsa-miR-20a-5p PDGFRA 2.13553469875764 0.000181201072324354 -4.31615823709194 9.59580352063599e-06 MirTarget;miRNATAP -0.567299949346882 2.96977674996385e-09 NA NA NA hsa-miR-20b-5p PDGFRA 4.5662923200279 4.75238200639144e-05 -4.31615823709194 9.59580352063599e-06 MirTarget;miRNATAP -0.130673579448784 0.00796359807809751 NA NA NA hsa-miR-2110 PDGFRA 1.8070969695103 0.00137196847440523 -4.31615823709194 9.59580352063599e-06 MirTarget -0.294307403934914 0.00362701551176569 NA NA NA hsa-miR-219a-5p PDGFRA 0.993473018224215 0.125519257191974 -4.31615823709194 9.59580352063599e-06 MirTarget -0.329204993675169 0.000180641355808018 NA NA NA hsa-miR-224-5p PDGFRA 4.2725754042941 6.99983365278436e-06 -4.31615823709194 9.59580352063599e-06 MirTarget -0.180983373061526 0.00177407515227038 NA NA NA hsa-miR-24-3p PDGFRA 1.55853749533999 0.000524726461381821 -4.31615823709194 9.59580352063599e-06 MirTarget;miRNATAP -0.557629319889882 6.60110927772163e-06 NA NA NA hsa-miR-27a-3p PDGFRA 1.76094007417453 0.000216137556256765 -4.31615823709194 9.59580352063599e-06 MirTarget;miRNATAP -0.541698361583472 3.22811351990072e-06 NA NA NA hsa-miR-301a-3p PDGFRA 1.99338115332667 0.000813358604963724 -4.31615823709194 9.59580352063599e-06 MirTarget;miRNATAP -0.319823844411805 0.000624462369659605 NA NA NA hsa-miR-330-5p PDGFRA 2.25110496739954 0.000275527655397415 -4.31615823709194 9.59580352063599e-06 miRanda -0.279887405553284 0.00184527634111128 NA NA NA hsa-miR-335-3p PDGFRA 1.19503568251824 0.0938852560631551 -4.31615823709194 9.59580352063599e-06 mirMAP -0.399011852951966 2.54729494558275e-07 NA NA NA hsa-miR-339-5p PDGFRA 1.23326828594484 0.0307501214818698 -4.31615823709194 9.59580352063599e-06 miRanda -0.445649150056303 4.71947718860255e-06 NA NA NA hsa-miR-33a-5p PDGFRA 2.60046838991599 0.000472459723448608 -4.31615823709194 9.59580352063599e-06 MirTarget;miRNATAP -0.401227415359423 4.68699510138077e-08 NA NA NA hsa-miR-33b-5p PDGFRA 4.77891217497671 1.33695107675057e-08 -4.31615823709194 9.59580352063599e-06 MirTarget;miRNATAP -0.417676719939801 4.62228731851437e-11 NA NA NA hsa-miR-421 PDGFRA 1.97624148591545 0.000915838012451138 -4.31615823709194 9.59580352063599e-06 PITA;miRanda;miRNATAP -0.261259988987499 0.005444760084744 NA NA NA hsa-miR-429 PDGFRA 6.39965293994036 1.96920201593608e-18 -4.31615823709194 9.59580352063599e-06 miRanda;miRNATAP -0.246069016468543 0.000645893632657437 NA NA NA hsa-miR-454-3p PDGFRA 1.40269869979902 0.00366085847011367 -4.31615823709194 9.59580352063599e-06 MirTarget;miRNATAP -0.456035002792179 8.16868294338271e-05 NA NA NA hsa-miR-550a-5p PDGFRA 1.21781238856895 0.0613791144699551 -4.31615823709194 9.59580352063599e-06 MirTarget -0.330426749632516 0.000118451208040612 NA NA NA hsa-miR-576-5p PDGFRA 1.30320223793746 0.00648929463912994 -4.31615823709194 9.59580352063599e-06 mirMAP -0.566981132043652 1.0311095468956e-06 NA NA NA hsa-miR-589-3p PDGFRA 1.33205316880069 0.052632683806148 -4.31615823709194 9.59580352063599e-06 mirMAP -0.292397869554739 0.000347972467306377 NA NA NA hsa-miR-590-3p PDGFRA 2.35429565068338 2.79601879608564e-06 -4.31615823709194 9.59580352063599e-06 miRanda;mirMAP -0.486413160870772 8.89956355896103e-06 NA NA NA hsa-miR-590-5p PDGFRA 1.51400888103768 0.0023888567923017 -4.31615823709194 9.59580352063599e-06 miRanda -0.571701323857916 2.55352789240418e-07 NA NA NA hsa-miR-616-5p PDGFRA 2.48416313933027 0.00318247475868827 -4.31615823709194 9.59580352063599e-06 mirMAP -0.288805433307288 0.000485679968015046 NA NA NA hsa-miR-7-1-3p PDGFRA 1.43074343339835 0.00471215970502094 -4.31615823709194 9.59580352063599e-06 mirMAP -0.298820288824693 0.0071101303035319 NA NA NA hsa-miR-93-5p PDGFRA 2.65964181833033 2.58315947526774e-08 -4.31615823709194 9.59580352063599e-06 MirTarget;miRNATAP -0.64786722499128 1.07665753473659e-08 NA NA NA hsa-miR-944 PDGFRA 7.20925181386398 0.000823207457340648 -4.31615823709194 9.59580352063599e-06 mirMAP -0.148526701539017 2.75742723317954e-06 NA NA NA hsa-miR-96-5p PDGFRA 5.62521466029286 1.54938806718028e-10 -4.31615823709194 9.59580352063599e-06 TargetScan;miRNATAP -0.397453542320597 9.60638780124384e-08 NA NA NA hsa-miR-224-5p PDGFRB 4.2725754042941 6.99983365278436e-06 -3.00627214348519 7.34667780692721e-05 miRNAWalker2_validate -0.146201861578625 0.00110933147204739 NA NA NA hsa-miR-34a-5p PDGFRB 0.830377770217786 0.0477544831885907 -3.00627214348519 7.34667780692721e-05 MirTarget -0.312602617436571 0.00280746999217784 24837198 MicroRNA 34A inhibits the growth invasion and metastasis of gastric cancer by targeting PDGFR and MET expression; In this study our aim was to identify the miRNAs that target PDGFR-α/β and to study the functions of these miRNAs miR-34a was predicted to target PDGFR and luciferase reporter assays showed that miR-34a could directly target PDGFR; Moreover the cancer-associated cell signalling pathway was studied and we found that miR-34a could inhibit Akt PKB protein kinase B phosphorylation which was restored by the overexpression of both PDGFR and MET; In conclusion miR-34a may act as a potential tumour suppressor in gastric cancer and is associated with the mechanisms of gastric cancer metastasis; miR-34a can inhibit gastric cancer tumourigenesis by targeting PDGFR and MET through the PI3K phosphoinositide 3-kinase/Akt pathway metastasis gastric cancer hsa-miR-361-3p PDGFRB 0.805698609170807 0.0418491665498322 -3.00627214348519 7.34667780692721e-05 MirTarget -0.366005767450926 0.000965550104549401 NA NA NA hsa-miR-484 PDGFRB 1.79050445056016 0.000217287101253701 -3.00627214348519 7.34667780692721e-05 mirMAP -0.32636125869027 0.00025262001509626 NA NA NA hsa-miR-2355-5p PDPK1 0.418226038913005 0.502149040287915 0.306582564392546 0.475941655495172 mirMAP -0.103108226134942 0.00842031347464144 NA NA NA hsa-miR-331-3p PDPK1 2.60769294751513 3.84318952029483e-07 0.306582564392546 0.475941655495172 miRNAWalker2_validate -0.121492218481836 0.00927780113542185 NA NA NA hsa-miR-335-5p PDPK1 0.167216045757305 0.803897055331049 0.306582564392546 0.475941655495172 mirMAP -0.119757895953739 0.000897643278107525 NA NA NA hsa-miR-374a-3p PDPK1 0.465360399099794 0.305267458251279 0.306582564392546 0.475941655495172 mirMAP -0.230622538416318 1.68353183571966e-05 NA NA NA hsa-miR-374b-5p PDPK1 -0.114749866169918 0.764888930049438 0.306582564392546 0.475941655495172 miRNATAP -0.196301486044882 0.00227955878743118 NA NA NA hsa-miR-424-5p PDPK1 0.209571188331903 0.753714747345068 0.306582564392546 0.475941655495172 mirMAP -0.107328960543962 0.00321761385868636 NA NA NA hsa-miR-505-3p PDPK1 0.58881333170866 0.226937454637888 0.306582564392546 0.475941655495172 mirMAP -0.160675222484928 0.00135084804850823 NA NA NA hsa-miR-590-3p PDPK1 2.35429565068338 2.79601879608564e-06 0.306582564392546 0.475941655495172 miRanda;miRNATAP -0.153973762930792 0.00126758596013474 NA NA NA hsa-miR-7-1-3p PDPK1 1.43074343339835 0.00471215970502094 0.306582564392546 0.475941655495172 mirMAP -0.167155439005958 0.000480585137518429 NA NA NA hsa-miR-708-3p PDPK1 0.781444321399141 0.290645825716608 0.306582564392546 0.475941655495172 miRNATAP -0.102610127578191 0.00176122802875978 NA NA NA hsa-miR-34a-5p PGF 0.830377770217786 0.0477544831885907 0.0255711984152289 0.97888604472598 miRNATAP -0.469702846148815 0.00034617557544533 NA NA NA hsa-miR-429 PGF 6.39965293994036 1.96920201593608e-18 0.0255711984152289 0.97888604472598 miRNATAP -0.260855037574621 0.000203354450361377 NA NA NA hsa-miR-29b-1-5p PHLPP1 0.33698032160171 0.598092174563471 0.337809875979306 0.423798199202296 MirTarget -0.140415282957158 0.000175197334847089 NA NA NA hsa-miR-338-5p PHLPP1 -0.108304629897487 0.894675560494607 0.337809875979306 0.423798199202296 MirTarget;miRNATAP -0.11739666413218 5.49649283747547e-05 NA NA NA hsa-miR-141-5p PHLPP2 7.13744624551943 4.06877058732583e-26 -1.08180409105584 0.0171506195284889 MirTarget -0.132014574608101 0.000150541638750558 24945731 MicroRNA 141 promotes the proliferation of non small cell lung cancer cells by regulating expression of PHLPP1 and PHLPP2; Together the results of this study suggest that miR-141 and its targets PHLPP1 and PHLPP2 play critical roles in NSCLC tumorigenesis and provide potential therapeutic targets for NSCLC treatment tumorigenesis lung squamous cell cancer hsa-miR-142-5p PHLPP2 3.95552531913424 1.49536283724079e-08 -1.08180409105584 0.0171506195284889 mirMAP -0.108065304590816 0.00265493107070097 NA NA NA hsa-miR-21-3p PHLPP2 3.50297439576639 6.39946844099206e-10 -1.08180409105584 0.0171506195284889 mirMAP -0.126517023286179 0.00427407826787136 NA NA NA hsa-miR-27a-3p PHLPP2 1.76094007417453 0.000216137556256765 -1.08180409105584 0.0171506195284889 MirTarget;miRNATAP -0.19625433672878 0.000262542945244713 NA NA NA hsa-miR-27b-3p PHLPP2 -0.0929089601968123 0.85847352206581 -1.08180409105584 0.0171506195284889 MirTarget;miRNATAP -0.265808155471155 5.52019406719337e-08 NA NA NA hsa-miR-29c-3p PHLPP2 -0.414153610337085 0.529344128062017 -1.08180409105584 0.0171506195284889 miRNATAP -0.133058419847695 0.000664164717944463 NA NA NA hsa-miR-342-3p PHLPP2 1.31107714473009 0.0207211910724662 -1.08180409105584 0.0171506195284889 miRanda -0.173602385607389 0.000123730610954559 NA NA NA hsa-miR-30d-3p PIK3AP1 -0.0740421896025512 0.857423650167556 1.56764922874658 0.0367038695004553 miRNATAP -0.317616599455067 0.00244036914086124 NA NA NA hsa-miR-92a-3p PIK3AP1 1.87892405805529 1.27013821556583e-05 1.56764922874658 0.0367038695004553 MirTarget -0.304535144542646 0.00201082505278975 NA NA NA hsa-miR-940 PIK3AP1 3.78496690968119 4.75227557809023e-05 1.56764922874658 0.0367038695004553 MirTarget -0.149711579685841 0.00691265346333153 NA NA NA hsa-miR-148b-3p PIK3CA 1.75622244535669 8.84414356040579e-08 0.514328426212782 0.248930105421785 miRNAWalker2_validate -0.244141801200414 0.00147579635788138 NA NA NA hsa-miR-186-5p PIK3CA 0.445443449112564 0.185447310527704 0.514328426212782 0.248930105421785 mirMAP -0.280960133798979 0.000232701716483115 NA NA NA hsa-miR-29b-1-5p PIK3CA 0.33698032160171 0.598092174563471 0.514328426212782 0.248930105421785 mirMAP -0.12089066483943 0.00233700941849917 NA NA NA hsa-miR-320b PIK3CA 0.20205459771295 0.727216419960509 0.514328426212782 0.248930105421785 miRanda -0.121444800770151 0.00550932456475504 NA NA NA hsa-miR-335-5p PIK3CA 0.167216045757305 0.803897055331049 0.514328426212782 0.248930105421785 miRNAWalker2_validate -0.124494566731403 0.000883627732385134 NA NA NA hsa-miR-338-5p PIK3CA -0.108304629897487 0.894675560494607 0.514328426212782 0.248930105421785 mirMAP -0.108048495334147 0.00046563589386498 NA NA NA hsa-miR-339-5p PIK3CA 1.23326828594484 0.0307501214818698 0.514328426212782 0.248930105421785 miRanda -0.13798173006655 0.00178425799549926 NA NA NA hsa-miR-501-5p PIK3CA 1.0411896821345 0.0777206709183552 0.514328426212782 0.248930105421785 mirMAP -0.120904681333791 0.00473986403400753 NA NA NA hsa-miR-130a-3p PIK3CB 0.176861046122832 0.7577473016872 0.897158330473952 0.0125840363244796 miRNATAP -0.116582529549782 0.00106378240800672 NA NA NA hsa-miR-19b-3p PIK3CB 1.67581705793313 0.000858910586302716 0.897158330473952 0.0125840363244796 miRNATAP -0.110401307134748 0.00639042894521705 NA NA NA hsa-miR-1468-5p PIK3CD -1.63442718498426 0.00779372976116312 0.0551399776366237 0.926564879247674 MirTarget -0.153354934509346 0.00559561965869134 NA NA NA hsa-miR-199a-5p PIK3CD -1.24888110793613 0.0747755616523728 0.0551399776366237 0.926564879247674 MirTarget;PITA;miRanda;miRNATAP -0.160352223725155 0.000860262558034989 NA NA NA hsa-miR-30d-5p PIK3CD 0.302504510257496 0.380193536606962 0.0551399776366237 0.926564879247674 MirTarget;miRNATAP -0.269704587228763 0.00722775970426478 NA NA NA hsa-miR-3913-5p PIK3CD 0.145645056779437 0.734844256690741 0.0551399776366237 0.926564879247674 mirMAP -0.258109601835399 0.00117084989668902 NA NA NA hsa-miR-335-3p PIK3CG 1.19503568251824 0.0938852560631551 -0.156343505309127 0.848670326900117 mirMAP -0.289128547018831 6.98940085423769e-06 NA NA NA hsa-miR-16-2-3p PIK3R1 3.79845098071094 1.49120139344659e-13 -1.85375256159008 0.0127438113463991 MirTarget -0.220421111740374 0.0054973163518176 NA NA NA hsa-miR-16-5p PIK3R1 2.93575808220754 2.15436817162977e-10 -1.85375256159008 0.0127438113463991 MirTarget -0.232718839097215 0.0094069232214411 NA NA NA hsa-miR-17-5p PIK3R1 2.3269271449522 2.13987445663942e-05 -1.85375256159008 0.0127438113463991 MirTarget;TargetScan;miRNATAP -0.263550021803503 0.000561403048031031 NA NA NA hsa-miR-200c-3p PIK3R1 6.47012025883743 2.64500707716408e-26 -1.85375256159008 0.0127438113463991 mirMAP -0.209884750055895 0.000971059963262446 NA NA NA hsa-miR-29b-3p PIK3R1 0.666547117072858 0.234055379278093 -1.85375256159008 0.0127438113463991 MirTarget;miRNATAP -0.229458801110313 0.00247922380727846 NA NA NA hsa-miR-3065-5p PIK3R1 2.14185373842821 0.0609400502269891 -1.85375256159008 0.0127438113463991 MirTarget;mirMAP;miRNATAP -0.136442762182432 0.00300321263691178 NA NA NA hsa-miR-320c PIK3R1 -0.10618808730545 0.854002814666472 -1.85375256159008 0.0127438113463991 miRNATAP -0.237528056213487 0.00153215444016214 NA NA NA hsa-miR-330-3p PIK3R1 2.49094236945806 0.000129367003214715 -1.85375256159008 0.0127438113463991 MirTarget;PITA;miRNATAP -0.222421511130143 0.000560333266659095 NA NA NA hsa-miR-335-3p PIK3R1 1.19503568251824 0.0938852560631551 -1.85375256159008 0.0127438113463991 mirMAP -0.187424798668302 0.00154671007013318 NA NA NA hsa-miR-338-5p PIK3R1 -0.108304629897487 0.894675560494607 -1.85375256159008 0.0127438113463991 PITA -0.149038254580324 0.00415133065382571 NA NA NA hsa-miR-582-5p PIK3R1 0.685177900016753 0.447761540297692 -1.85375256159008 0.0127438113463991 mirMAP -0.168928206892885 0.000293205730117536 NA NA NA hsa-miR-584-5p PIK3R1 1.17912816682866 0.202862496863776 -1.85375256159008 0.0127438113463991 mirMAP -0.264485629334745 3.0909574049315e-09 NA NA NA hsa-miR-590-5p PIK3R1 1.51400888103768 0.0023888567923017 -1.85375256159008 0.0127438113463991 MirTarget;PITA;miRanda;miRNATAP -0.297003967343676 0.000452335914243657 NA NA NA hsa-miR-629-3p PIK3R1 3.48282157979573 4.9176538695908e-08 -1.85375256159008 0.0127438113463991 MirTarget -0.21216292379107 0.00105654186835094 NA NA NA hsa-miR-1271-5p PIK3R3 0.212382644103427 0.742544160267329 -0.029728653396571 0.959330193755408 mirMAP -0.151933011438603 0.00299533512999816 NA NA NA hsa-miR-18a-3p PIK3R3 3.64944956993027 7.20156641833731e-07 -0.029728653396571 0.959330193755408 miRNAWalker2_validate -0.172437749406846 8.76134189601592e-05 NA NA NA hsa-miR-222-5p PIK3R3 2.52056758362407 0.00142010793166944 -0.029728653396571 0.959330193755408 mirMAP -0.169591357898129 3.80520658072856e-05 NA NA NA hsa-miR-29b-1-5p PIK3R3 0.33698032160171 0.598092174563471 -0.029728653396571 0.959330193755408 mirMAP -0.214703534793861 3.15537480066889e-05 NA NA NA hsa-miR-330-3p PIK3R3 2.49094236945806 0.000129367003214715 -0.029728653396571 0.959330193755408 MirTarget -0.191183653307302 0.000135580399986553 NA NA NA hsa-miR-330-5p PIK3R3 2.25110496739954 0.000275527655397415 -0.029728653396571 0.959330193755408 miRanda -0.158989578902319 0.00262587059425892 NA NA NA hsa-miR-365a-3p PIK3R3 0.25545896241765 0.654320504621012 -0.029728653396571 0.959330193755408 MirTarget -0.330277583325266 6.38384266733533e-09 NA NA NA hsa-miR-511-5p PIK3R3 1.10428503984162 0.179276103915417 -0.029728653396571 0.959330193755408 MirTarget -0.179185145111208 6.38466351145281e-06 25608840 MiR 511 inhibits growth and metastasis of human hepatocellular carcinoma cells by targeting PIK3R3; We further demonstrated that miR-511 suppressed HCC cell proliferation migration and invasion by repressing PIK3R3 expression metastasis liver cancer hsa-miR-590-5p PIK3R3 1.51400888103768 0.0023888567923017 -0.029728653396571 0.959330193755408 miRanda -0.195493025557274 0.00311783468590026 NA NA NA hsa-miR-125a-3p PIK3R5 -0.0748960586927341 0.920735897434087 0.75811064163987 0.286920846128457 miRanda -0.143772140191083 0.00747323319002246 NA NA NA hsa-miR-125a-5p PIK3R5 -1.32352790615388 0.00714301627309467 0.75811064163987 0.286920846128457 MirTarget;miRanda -0.250957855170204 0.00223286885929377 NA NA NA hsa-miR-182-5p PIK3R5 5.86988712704738 1.22411588571584e-15 0.75811064163987 0.286920846128457 MirTarget -0.25329203027594 9.2894340160784e-07 NA NA NA hsa-miR-194-3p PIK3R6 1.91743783341496 0.105383373371284 0.423461713034892 0.581944788847249 MirTarget -0.117241986030545 0.00148902857929864 NA NA NA hsa-miR-30c-2-3p PIK3R6 -0.916427677918778 0.300195789569016 0.423461713034892 0.581944788847249 MirTarget -0.163567096490306 0.000849564237751836 NA NA NA hsa-miR-590-3p PKN2 2.35429565068338 2.79601879608564e-06 0.369594487755501 0.260660633940506 PITA;miRanda;mirMAP -0.110576313524262 0.002419987519427 NA NA NA hsa-miR-425-5p PPP2CB 3.15197291080781 3.16652350906107e-07 -1.25447828974493 1.05312923428955e-05 miRNAWalker2_validate -0.110681790089799 1.64448494638146e-05 NA NA NA hsa-miR-590-3p PPP2CB 2.35429565068338 2.79601879608564e-06 -1.25447828974493 1.05312923428955e-05 miRanda -0.128757858804767 5.16847568396067e-05 NA NA NA hsa-miR-125a-5p PPP2R1B -1.32352790615388 0.00714301627309467 0.535943295428266 0.162251997298493 PITA;miRanda -0.114930033410317 0.00930190483964423 NA NA NA hsa-miR-452-5p PPP2R1B 2.45466810475361 0.00114794259949532 0.535943295428266 0.162251997298493 MirTarget -0.106017919286185 0.000183245518742969 NA NA NA hsa-let-7d-5p PPP2R2A 0.831142050231414 0.0126955498524287 0.0960064985970766 0.7750778187388 miRNATAP -0.174926776698754 0.00247398044986799 NA NA NA hsa-let-7g-5p PPP2R2A 0.857251702023746 0.00647597344297273 0.0960064985970766 0.7750778187388 miRNATAP -0.176225566865877 0.00411980688463905 NA NA NA hsa-miR-10a-3p PPP2R2B 0.970411431936568 0.31667483998251 0.510382229560619 0.717532337027209 mirMAP -0.361340250716247 1.45994602012054e-05 NA NA NA hsa-miR-495-3p PPP2R2B -1.28495103468384 0.0979462503954353 0.510382229560619 0.717532337027209 mirMAP -0.288356788930344 0.00509581279052137 NA NA NA hsa-miR-10a-3p PPP2R2C 0.970411431936568 0.31667483998251 -2.54177583085932 0.149641186912383 mirMAP -0.52601694399535 4.06707476577951e-07 NA NA NA hsa-miR-125a-3p PPP2R2C -0.0748960586927341 0.920735897434087 -2.54177583085932 0.149641186912383 miRanda -0.356181842692916 0.00760457791329202 NA NA NA hsa-miR-192-5p PPP2R2C 1.77716187978541 0.113485496183047 -2.54177583085932 0.149641186912383 mirMAP -0.265151327819773 0.00280195654279779 NA NA NA hsa-miR-194-5p PPP2R2C 0.691219038144468 0.523143086635506 -2.54177583085932 0.149641186912383 miRNATAP -0.291408118524632 0.00155852789752536 NA NA NA hsa-miR-200b-3p PPP2R2C 5.56167217794639 6.43540045061709e-16 -2.54177583085932 0.149641186912383 TargetScan -0.540897516262644 8.39233236739658e-05 NA NA NA hsa-miR-200c-3p PPP2R2C 6.47012025883743 2.64500707716408e-26 -2.54177583085932 0.149641186912383 miRNATAP -0.449989786928302 0.00282829298525296 NA NA NA hsa-miR-429 PPP2R2C 6.39965293994036 1.96920201593608e-18 -2.54177583085932 0.149641186912383 PITA;miRanda;miRNATAP -0.403238519278253 0.00175993756486531 NA NA NA hsa-miR-625-5p PPP2R2C 2.02792641909347 0.000935142379948297 -2.54177583085932 0.149641186912383 MirTarget -0.593528145578647 0.000275541485817671 NA NA NA hsa-miR-106a-5p PPP2R3A 3.98693608217557 9.37722470816656e-07 -0.356770230293888 0.647923273531564 mirMAP -0.207001280053113 9.56936141063903e-05 NA NA NA hsa-miR-125a-5p PPP2R3A -1.32352790615388 0.00714301627309467 -0.356770230293888 0.647923273531564 miRanda -0.233725562966436 0.00958647085804766 NA NA NA hsa-miR-148b-3p PPP2R3A 1.75622244535669 8.84414356040579e-08 -0.356770230293888 0.647923273531564 miRNAWalker2_validate -0.549506170433832 4.08835612693584e-05 NA NA NA hsa-miR-181b-5p PPP2R3A 1.11397227523501 0.0273417050354018 -0.356770230293888 0.647923273531564 MirTarget -0.22907704480106 0.00926985187330002 NA NA NA hsa-miR-181c-5p PPP2R3A -0.302833440762172 0.537532549455539 -0.356770230293888 0.647923273531564 MirTarget -0.374113753877879 3.30662488175765e-05 NA NA NA hsa-miR-181d-5p PPP2R3A -0.529098579553155 0.325262124523294 -0.356770230293888 0.647923273531564 MirTarget -0.258240819097389 0.0017631433450012 NA NA NA hsa-miR-20b-3p PPP2R3A 3.32857825638616 0.0632388433748268 -0.356770230293888 0.647923273531564 MirTarget -0.205423413882191 1.81172544288174e-06 NA NA NA hsa-miR-20b-5p PPP2R3A 4.5662923200279 4.75238200639144e-05 -0.356770230293888 0.647923273531564 mirMAP -0.145190374709472 0.000169070159274506 NA NA NA hsa-miR-320b PPP2R3A 0.20205459771295 0.727216419960509 -0.356770230293888 0.647923273531564 miRanda -0.205654741369774 0.00738901720750606 NA NA NA hsa-miR-34a-5p PPP2R3A 0.830377770217786 0.0477544831885907 -0.356770230293888 0.647923273531564 MirTarget;miRNATAP -0.32661918993157 0.00214583782485317 NA NA NA hsa-miR-375 PPP2R3A 3.3784490463318 0.0449946294355695 -0.356770230293888 0.647923273531564 miRanda -0.205680675222261 1.21302245541306e-16 NA NA NA hsa-miR-429 PPP2R3A 6.39965293994036 1.96920201593608e-18 -0.356770230293888 0.647923273531564 miRanda -0.211352912661137 0.000196622785672102 NA NA NA hsa-miR-589-5p PPP2R3A 1.55790780760302 0.000326340665093671 -0.356770230293888 0.647923273531564 MirTarget -0.357238887139832 0.000452006619503153 NA NA NA hsa-miR-107 PPP2R5A 1.49443409571439 0.000130594521065411 -0.140489073340774 0.671690982688938 miRanda -0.144398642769006 0.00260012205894746 NA NA NA hsa-miR-186-5p PPP2R5C 0.445443449112564 0.185447310527704 -0.316038762242836 0.26720752514426 mirMAP;miRNATAP -0.180523874486163 0.000196249408190972 NA NA NA hsa-miR-101-5p PPP2R5E -1.41522721523565 0.0166784131265028 0.535525914733393 0.120928926594593 MirTarget -0.180690176030252 2.46208790792195e-08 NA NA NA hsa-miR-125a-5p PPP2R5E -1.32352790615388 0.00714301627309467 0.535525914733393 0.120928926594593 miRNAWalker2_validate -0.179165818069827 5.17839779064056e-06 NA NA NA hsa-miR-181c-5p PPP2R5E -0.302833440762172 0.537532549455539 0.535525914733393 0.120928926594593 MirTarget;mirMAP -0.16820871881031 2.25744067324159e-05 NA NA NA hsa-miR-195-3p PPP2R5E -2.39100534119332 0.000185405399054065 0.535525914733393 0.120928926594593 mirMAP -0.121161783375062 6.09529627319605e-05 NA NA NA hsa-miR-29b-2-5p PPP2R5E -0.596051745078872 0.189540844841389 0.535525914733393 0.120928926594593 mirMAP -0.240263449414642 1.5497933709251e-08 NA NA NA hsa-miR-30a-5p PPP2R5E -0.768430903969183 0.320487552854215 0.535525914733393 0.120928926594593 mirMAP -0.111068835600136 8.55978751796861e-06 NA NA NA hsa-miR-30b-5p PPP2R5E 0.0238659735605804 0.953223658270319 0.535525914733393 0.120928926594593 mirMAP -0.149474692025846 0.00208479541033403 NA NA NA hsa-miR-30d-3p PPP2R5E -0.0740421896025512 0.857423650167556 0.535525914733393 0.120928926594593 MirTarget -0.144308649360449 0.00260698547448653 NA NA NA hsa-miR-30e-3p PPP2R5E -0.0362193022195196 0.932577027239525 0.535525914733393 0.120928926594593 MirTarget -0.119486384973344 0.00965259842012976 NA NA NA hsa-miR-30e-5p PPP2R5E 0.780047227271616 0.0346714425913016 0.535525914733393 0.120928926594593 mirMAP -0.190433556521116 0.000361265009878909 NA NA NA hsa-miR-3607-3p PPP2R5E 1.38015131722213 0.0240067155694847 0.535525914733393 0.120928926594593 mirMAP;miRNATAP -0.102503532433218 0.00126886534770206 NA NA NA hsa-miR-374b-5p PPP2R5E -0.114749866169918 0.764888930049438 0.535525914733393 0.120928926594593 mirMAP -0.141522657991467 0.00619666437031856 NA NA NA hsa-miR-19a-3p PRKAA1 2.17020503944519 0.00122084653711062 -0.14272062956041 0.708457800162383 miRNATAP -0.121877936085399 0.000121351742732488 NA NA NA hsa-miR-19b-3p PRKAA1 1.67581705793313 0.000858910586302716 -0.14272062956041 0.708457800162383 miRNAWalker2_validate;miRTarBase;miRNATAP -0.1436893824791 0.000755247351571621 NA NA NA hsa-miR-590-3p PRKAA1 2.35429565068338 2.79601879608564e-06 -0.14272062956041 0.708457800162383 MirTarget;miRanda;mirMAP -0.159819133040541 0.000152519009478064 NA NA NA hsa-miR-590-5p PRKAA1 1.51400888103768 0.0023888567923017 -0.14272062956041 0.708457800162383 miRanda -0.127622456320397 0.00312575183340519 NA NA NA hsa-miR-142-5p PRKAA2 3.95552531913424 1.49536283724079e-08 -1.64186892044043 0.304588246308584 mirMAP -0.733679899144415 3.28129434658743e-09 NA NA NA hsa-miR-146a-5p PRKAA2 2.64646698525354 0.000280611928973036 -1.64186892044043 0.304588246308584 MirTarget -0.510281421549701 3.0466836944546e-05 NA NA NA hsa-miR-146b-5p PRKAA2 1.87569569182453 0.000737241069698886 -1.64186892044043 0.304588246308584 MirTarget -0.677636044535875 2.66207392598239e-05 NA NA NA hsa-miR-150-3p PRKAA2 1.65258591448117 0.058477568382345 -1.64186892044043 0.304588246308584 MirTarget;miRNATAP -0.563781561577572 7.53911077950056e-08 NA NA NA hsa-miR-203a-3p PRKAA2 6.35084246337388 7.89944323347948e-08 -1.64186892044043 0.304588246308584 MirTarget -0.432436265326421 3.35611293563868e-09 NA NA NA hsa-miR-22-5p PRKAA2 2.38337850108621 1.0773503998394e-05 -1.64186892044043 0.304588246308584 mirMAP -0.470263121239052 0.00457421554834218 NA NA NA hsa-miR-23a-3p PRKAA2 0.925125296618358 0.0127293543936914 -1.64186892044043 0.304588246308584 mirMAP -0.71119737453032 0.00405550837945771 NA NA NA hsa-miR-27b-5p PRKAA2 0.213392605793392 0.71562473353293 -1.64186892044043 0.304588246308584 MirTarget;miRNATAP -0.60817407358398 8.32905119807132e-05 NA NA NA hsa-miR-342-3p PRKAA2 1.31107714473009 0.0207211910724662 -1.64186892044043 0.304588246308584 PITA -1.02655657966323 4.19058043429419e-11 NA NA NA hsa-miR-34c-3p PRKAA2 4.0411891981675 0.000195495966405666 -1.64186892044043 0.304588246308584 PITA -0.348300367275928 2.34411683541998e-05 NA NA NA hsa-miR-34c-5p PRKAA2 2.64675661251039 0.0157394735757952 -1.64186892044043 0.304588246308584 miRNATAP -0.346761506200615 2.1638696771148e-05 NA NA NA hsa-miR-590-3p PRKAA2 2.35429565068338 2.79601879608564e-06 -1.64186892044043 0.304588246308584 mirMAP;miRNATAP -0.47594243821822 0.00777370830247716 NA NA NA hsa-miR-944 PRKAA2 7.20925181386398 0.000823207457340648 -1.64186892044043 0.304588246308584 mirMAP -0.379896831337975 2.22682094114287e-14 NA NA NA hsa-miR-142-5p PRKCA 3.95552531913424 1.49536283724079e-08 -2.51484065178579 0.000301846026330391 mirMAP -0.157985182568495 0.00450284307697346 NA NA NA hsa-miR-183-5p PRKCA 6.61903249270777 1.00958881445636e-16 -2.51484065178579 0.000301846026330391 miRNATAP -0.195964689338451 2.96312561009603e-05 NA NA NA hsa-miR-200c-3p PRKCA 6.47012025883743 2.64500707716408e-26 -2.51484065178579 0.000301846026330391 miRNATAP -0.227644911192639 0.000134967313056447 NA NA NA hsa-miR-30e-3p PRKCA -0.0362193022195196 0.932577027239525 -2.51484065178579 0.000301846026330391 mirMAP -0.330264937460595 0.000431865199778726 NA NA NA hsa-miR-330-3p PRKCA 2.49094236945806 0.000129367003214715 -2.51484065178579 0.000301846026330391 mirMAP -0.173880498227238 0.0042321147753766 NA NA NA hsa-miR-340-5p PRKCA 1.41210478721579 0.00958612942879818 -2.51484065178579 0.000301846026330391 mirMAP -0.247780249808726 0.000683356782218492 NA NA NA hsa-miR-374a-3p PRKCA 0.465360399099794 0.305267458251279 -2.51484065178579 0.000301846026330391 mirMAP -0.324087022951615 0.000236966482552477 NA NA NA hsa-miR-374a-5p PRKCA 0.278549982012055 0.45888283715888 -2.51484065178579 0.000301846026330391 mirMAP -0.315860192203564 0.00334938709870334 NA NA NA hsa-miR-590-3p PRKCA 2.35429565068338 2.79601879608564e-06 -2.51484065178579 0.000301846026330391 PITA;miRanda;mirMAP;miRNATAP -0.344157378397527 9.41463074505618e-06 NA NA NA hsa-miR-9-5p PRKCA 1.79620806707734 0.14526963042518 -2.51484065178579 0.000301846026330391 miRNATAP -0.102263861653536 0.00143068318206041 NA NA NA hsa-miR-944 PRKCA 7.20925181386398 0.000823207457340648 -2.51484065178579 0.000301846026330391 PITA;miRNATAP -0.163061119524878 9.18211721568101e-14 NA NA NA hsa-let-7a-3p PRLR 0.82512001802525 0.0468122405194487 -5.28037380437679 0.000876404303480571 mirMAP -0.842138069892473 0.000126621309469784 NA NA NA hsa-let-7d-5p PRLR 0.831142050231414 0.0126955498524287 -5.28037380437679 0.000876404303480571 miRNATAP -0.930491683982486 0.000766642240170437 NA NA NA hsa-let-7f-1-3p PRLR 1.61507869803314 0.00069342464777815 -5.28037380437679 0.000876404303480571 mirMAP -0.816039096488304 1.7189814301318e-05 NA NA NA hsa-miR-103a-2-5p PRLR 2.77240253557299 0.000302548514615442 -5.28037380437679 0.000876404303480571 mirMAP -0.352698569249809 0.0029177555286185 NA NA NA hsa-miR-130a-3p PRLR 0.176861046122832 0.7577473016872 -5.28037380437679 0.000876404303480571 mirMAP -0.493070459822395 0.00189826933109988 NA NA NA hsa-miR-142-3p PRLR 4.35304505457969 3.10014573651358e-10 -5.28037380437679 0.000876404303480571 PITA;miRNATAP -0.338297209876975 0.00791744122447048 NA NA NA hsa-miR-15b-3p PRLR 3.57530146629867 5.89922785773482e-11 -5.28037380437679 0.000876404303480571 mirMAP -0.593478840866584 0.000220832631914752 NA NA NA hsa-miR-19b-1-5p PRLR 1.51335451095424 0.0014717605268143 -5.28037380437679 0.000876404303480571 mirMAP -0.675561023319356 0.000380483040108734 NA NA NA hsa-miR-20a-3p PRLR 1.9920766549842 0.000624458530894697 -5.28037380437679 0.000876404303480571 mirMAP -0.593345559646597 0.00011868945416843 NA NA NA hsa-miR-22-5p PRLR 2.38337850108621 1.0773503998394e-05 -5.28037380437679 0.000876404303480571 mirMAP -0.672975889551064 4.4066900239266e-05 NA NA NA hsa-miR-32-3p PRLR 2.20477794939766 0.0392771274032852 -5.28037380437679 0.000876404303480571 mirMAP -0.474650592165327 0.0014560346864996 NA NA NA hsa-miR-320b PRLR 0.20205459771295 0.727216419960509 -5.28037380437679 0.000876404303480571 miRanda -0.411977816204814 0.00889879225481238 NA NA NA hsa-miR-330-3p PRLR 2.49094236945806 0.000129367003214715 -5.28037380437679 0.000876404303480571 mirMAP;miRNATAP -0.581097580918294 2.36835535566655e-05 NA NA NA hsa-miR-33a-3p PRLR 2.06269680799532 0.00156436055383943 -5.28037380437679 0.000876404303480571 mirMAP -0.465474654123544 0.000786719970127142 NA NA NA hsa-miR-34c-5p PRLR 2.64675661251039 0.0157394735757952 -5.28037380437679 0.000876404303480571 miRanda;miRNATAP -0.232656206445797 0.0047193060370075 NA NA NA hsa-miR-3614-5p PRLR 4.50236405439456 2.75644515847367e-07 -5.28037380437679 0.000876404303480571 mirMAP -0.293570646395737 0.00391772270226576 NA NA NA hsa-miR-421 PRLR 1.97624148591545 0.000915838012451138 -5.28037380437679 0.000876404303480571 miRanda;mirMAP;miRNATAP -0.414314425852899 0.00642307231365017 NA NA NA hsa-miR-582-5p PRLR 0.685177900016753 0.447761540297692 -5.28037380437679 0.000876404303480571 PITA -0.26341521675333 0.0087427572780806 NA NA NA hsa-miR-9-3p PRLR 1.69328215716742 0.125170982657059 -5.28037380437679 0.000876404303480571 mirMAP -0.227290062681084 0.00630468933586122 NA NA NA hsa-miR-9-5p PRLR 1.79620806707734 0.14526963042518 -5.28037380437679 0.000876404303480571 miRNATAP -0.228612549871601 0.00177060824316513 NA NA NA hsa-miR-944 PRLR 7.20925181386398 0.000823207457340648 -5.28037380437679 0.000876404303480571 mirMAP -0.349135456877722 3.36718908955124e-12 NA NA NA hsa-miR-106a-5p PTEN 3.98693608217557 9.37722470816656e-07 -0.848820542036926 0.0698463061072717 miRNATAP -0.121150170909335 0.000141310345865052 26097565;26318586 miR 106a promotes growth and metastasis of non small cell lung cancer by targeting PTEN; Furthermore the presence of miR-106a was inversely correlated with PTEN in NSCLC tissues; Overall this study suggested that miR-106a inhibited the growth and metastasis of NSCLC cells by decreasing PTEN expression;Further pterostilbene through downregulation of miR-17-5p and miR-106a-5p expression both in tumors and systemic circulation rescued PTEN mRNA and protein levels leading to reduced tumor growth in vivo metastasis; lung squamous cell cancer;prostate cancer hsa-miR-130b-3p PTEN 3.9204771543282 1.2714917955808e-11 -0.848820542036926 0.0698463061072717 MirTarget;miRNATAP -0.139961927957452 0.00157623535045685 26837847;25637514 The miR 130 family promotes cell migration and invasion in bladder cancer through FAK and Akt phosphorylation by regulating PTEN; In clinical bladder cancer specimens downregulation of PTEN was found to be closely correlated with miR-130 family expression levels;MiR 130b plays an oncogenic role by repressing PTEN expression in esophageal squamous cell carcinoma cells; We confirmed that miR-130b interacted with the 3'-untranslated region of PTEN and that an increase in the expression level of miR-130b negatively affected the protein level of PTEN; However the dysregulation of miR-130b had no obvious impact on PTEN mRNA; As Akt is a downstream effector of PTEN we explored if miR-130b affected Akt expression and found that miR-130b indirectly regulated the level of phosphorylated Akt while total Akt protein remained unchanged; The results indicate that miR-130b plays an oncogenic role in ESCC cells by repressing PTEN expression and Akt phosphorylation which would be helpful in developing miRNA-based treatments for ESCC cell migration; bladder cancer;esophageal cancer hsa-miR-182-5p PTEN 5.86988712704738 1.22411588571584e-15 -0.848820542036926 0.0698463061072717 mirMAP -0.100967623222909 0.00331619412338393 NA NA NA hsa-miR-188-5p PTEN 1.39111178824125 0.0251592818948912 -0.848820542036926 0.0698463061072717 MirTarget;PITA;miRNATAP -0.123015522557534 0.0041039297017108 NA NA NA hsa-miR-200b-3p PTEN 5.56167217794639 6.43540045061709e-16 -0.848820542036926 0.0698463061072717 TargetScan;mirMAP -0.111724552597797 0.00227683849654151 22637745;21408027 Re expression of miR 200 by novel approaches regulates the expression of PTEN and MT1 MMP in pancreatic cancer; We initially compared the expression profile of miR-200 family PTEN and MT1-MMP expression in six pancreatic cancer PC cell lines by qRT-PCR and western blot analysis; The expression of miR-200 family and PTEN was significantly re-expressed whereas the expression of MT1-MMP was down-regulated by CDF and BR-DIM treatment; These results provide strong experimental evidence showing that the loss of miR-200 family and PTEN expression and increased level of MT1-MMP leads to aggressive behavior of PC cells which could be attenuated through re-expression of miR-200c by CDF and/or BR-DIM treatment suggesting that these agents could be useful for PC treatment;Anti tumor activity of a novel compound CDF is mediated by regulating miR 21 miR 200 and PTEN in pancreatic cancer; In a xenograft mouse model of human PC CDF treatment significantly inhibited tumor growth which was associated with decreased NF-κB DNA binding activity COX-2 and miR-21 expression and increased PTEN and miR-200 expression in tumor remnants ; pancreatic cancer;pancreatic cancer hsa-miR-25-3p PTEN 1.12623030168869 0.00311079344417173 -0.848820542036926 0.0698463061072717 miRTarBase;MirTarget;miRNATAP -0.346634698468156 5.85013644059584e-07 NA NA NA hsa-miR-28-5p PTEN -0.815636722979196 0.0221199948901761 -0.848820542036926 0.0698463061072717 miRanda -0.201833894647843 0.00766209794137583 NA NA NA hsa-miR-32-3p PTEN 2.20477794939766 0.0392771274032852 -0.848820542036926 0.0698463061072717 mirMAP -0.128718962710161 0.00318430811052814 24123284;25647261;23617834 In this study we determined the levels of the correlation between and the clinical significance of the expression of miR-32 and phosphatase and tensin homologue PTEN a tumor suppressor targeted by miR-32 in CRC; The levels of miR-32 and PTEN gene expression in 35 colorectal carcinoma samples 35 corresponding cancer-adjacent tissue samples 27 colorectal adenoma samples and 16 normal tissue samples were quantified using real-time quantitative reverse transcriptase-polymerase chain reaction; The relationship between the miR-32 and PTEN protein expression and clinicopathological factors was analyzed; Significant upregulation of miR-32 expression and reduction of PTEN were identified in CRC tissues; An inverse relationship between miR-32 and PTEN protein expression was identified; MiR-32 and PTEN expression were inversely correlated and miR-32 may be associated with the development of CRC;MiR 32 induces cell proliferation migration and invasion in hepatocellular carcinoma by targeting PTEN; Besides miRNA-32 down-regulates PTEN through binding to 3'-UTR of PTEN mRNA from luciferase reporter assay and the expression level of miR-32 could affect the proliferation migration and invasion of liver cancer cell lines via PTEN/Akt signaling pathway; Down-expression of PTEN could significantly attenuate the inhibitory effects of knockdown miR-32 on the proliferation migration and invasion of liver cancer cells suggesting that miR-32 could be a potential target for HCC treatment;MicroRNA 32 miR 32 regulates phosphatase and tensin homologue PTEN expression and promotes growth migration and invasion in colorectal carcinoma cells; In this study we identified the potential effects of miR-32 on some important biological properties of CRC cells and clarified the regulation of PTEN by miR-32; The 3'-untranslated region 3'-UTR of PTEN combined with miR-32 was verified by dual-luciferase reporter assay; Gain-of-function and loss-of-function studies showed that overexpression of miR-32 promoted SW480 cell proliferation migration and invasion reduced apoptosis and resulted in downregulation of PTEN at a posttranscriptional level; However miR-32 knock-down inhibited these processes in HCT-116 cells and enhanced the expression of PTEN protein; In addition we further identified PTEN as the functional downstream target of miR-32 by directly targeting the 3'-UTR of PTEN; Our results demonstrated that miR-32 was involved in tumorigenesis of CRC at least in part by suppression of PTEN ;;tumorigenesis colorectal cancer;liver cancer;colorectal cancer hsa-miR-374b-5p PTEN -0.114749866169918 0.764888930049438 -0.848820542036926 0.0698463061072717 MirTarget;mirMAP;miRNATAP -0.184462823771875 0.00876765791811961 NA NA NA hsa-miR-421 PTEN 1.97624148591545 0.000915838012451138 -0.848820542036926 0.0698463061072717 miRanda -0.135924707077455 0.00219014673757631 NA NA NA hsa-miR-532-5p PTEN -0.297424983759107 0.503934707453099 -0.848820542036926 0.0698463061072717 PITA;mirMAP;miRNATAP -0.208656603286142 0.000512381739154765 NA NA NA hsa-miR-590-3p PTEN 2.35429565068338 2.79601879608564e-06 -0.848820542036926 0.0698463061072717 MirTarget;PITA;miRanda;mirMAP -0.140657129239091 0.00714320619469358 23803188 Targetscan predicted PDCD4 and PTEN as the potential target genes of miR-590-5p and miR-590-3p which was verified by luciferase reporter system and Western blotting; miR-590-3p was found to activate PI3K-AKT signaling pathway by down-regulating PTEN to promote AKT1-S473 phosphorylation liver cancer hsa-miR-7-1-3p PTEN 1.43074343339835 0.00471215970502094 -0.848820542036926 0.0698463061072717 mirMAP -0.176200102858594 0.000755349982671746 NA NA NA hsa-miR-744-3p PTEN 1.08385719878174 0.131243679775541 -0.848820542036926 0.0698463061072717 miRNATAP -0.108079947024833 0.0033964072740039 NA NA NA hsa-miR-93-5p PTEN 2.65964181833033 2.58315947526774e-08 -0.848820542036926 0.0698463061072717 miRNAWalker2_validate;miRTarBase;miRNATAP -0.180023874518816 0.000957550001063743 25633810;26243299;22465665;26087719 MicroRNA 93 activates c Met/PI3K/Akt pathway activity in hepatocellular carcinoma by directly inhibiting PTEN and CDKN1A; We confirmed that miR-93 directly bound with the 3' untranslated regions of the tumor-suppressor genes PTEN and CDKN1A respectivelyand inhibited their expression; We concluded that miR-93 stimulated cell proliferation migration and invasion through the oncogenic c-Met/PI3K/Akt pathway and also inhibited apoptosis by directly inhibiting PTEN and CDKN1A expression in human HCC;microRNA 93 promotes cell proliferation via targeting of PTEN in Osteosarcoma cells; An miRNA miR-93 was significantly up-regulated whereas phosphatase and tensin homologue PTEN expression was significantly down-regulated in all tested OS cells when compared with hMSCs; Ectopic expression of miR-93 decreased PTEN protein levels; Taking these observations together miR-93 can be seen to play a critical role in carcinogenesis through suppression of PTEN and may serve as a therapeutic target for the treatment of OS;Furthermore we found that miR-93 can directly target PTEN and participates in the regulation of the AKT signaling pathway; MiR-93 inversely correlates with PTEN expression in CDDP-resistant and sensitive human ovarian cancer tissues;Furthermore our study found berberine could inhibit miR-93 expression and function in ovarian cancer as shown by an increase of its target PTEN an important tumor suppressor in ovarian cancer; More importantly A2780 cells that were treated with PTEN siRNA had a survival pattern that is similar to cells with miR-93 overexpression ;tumorigenesis;;poor survival liver cancer;sarcoma;ovarian cancer;ovarian cancer hsa-miR-140-5p PTK2 -0.634610285725923 0.126670572966239 0.0169252268225506 0.955885098049357 miRanda -0.117371495238972 0.00511931286364758 NA NA NA hsa-miR-374a-5p RAC1 0.278549982012055 0.45888283715888 0.0440982372971011 0.900045954349393 mirMAP -0.140356402054542 0.00882655342567711 NA NA NA hsa-miR-450b-5p RAC1 0.445103105471153 0.416021465008949 0.0440982372971011 0.900045954349393 mirMAP -0.108599310907085 0.00278942668689792 NA NA NA hsa-let-7f-2-3p RBL2 1.02768112108475 0.0787293499732611 -0.290362042828854 0.459600981952894 MirTarget -0.110938571443043 0.00433507096732033 NA NA NA hsa-miR-106b-5p RBL2 2.80565545918114 1.14547999022566e-09 -0.290362042828854 0.459600981952894 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.152134757968797 0.00122146155020016 NA NA NA hsa-miR-130a-5p RBL2 1.58028512890005 0.024346333013728 -0.290362042828854 0.459600981952894 MirTarget -0.10715821321623 0.000810244476557906 NA NA NA hsa-miR-32-3p RBL2 2.20477794939766 0.0392771274032852 -0.290362042828854 0.459600981952894 miRNATAP -0.128572933697516 0.000405541163046317 NA NA NA hsa-miR-335-3p RBL2 1.19503568251824 0.0938852560631551 -0.290362042828854 0.459600981952894 MirTarget -0.116365907107437 0.000164887689801712 NA NA NA hsa-miR-335-5p RBL2 0.167216045757305 0.803897055331049 -0.290362042828854 0.459600981952894 miRNAWalker2_validate -0.145019980739739 9.04060047371642e-06 NA NA NA hsa-miR-590-3p RBL2 2.35429565068338 2.79601879608564e-06 -0.290362042828854 0.459600981952894 miRanda -0.194960999183418 6.4906101255289e-06 NA NA NA hsa-miR-15b-5p RELN 3.32329949959268 8.40210501034588e-13 -4.56675081618191 0.00128745672091879 MirTarget;miRNATAP -0.492629692327408 0.00356060731431605 NA NA NA hsa-miR-16-5p RELN 2.93575808220754 2.15436817162977e-10 -4.56675081618191 0.00128745672091879 MirTarget;miRNATAP -0.549810269309647 0.00130915895444649 NA NA NA hsa-miR-193a-5p RELN 0.511907930518603 0.239278601221583 -4.56675081618191 0.00128745672091879 PITA -0.492198308856317 0.00905596025366692 NA NA NA hsa-miR-200c-3p RELN 6.47012025883743 2.64500707716408e-26 -4.56675081618191 0.00128745672091879 MirTarget -0.467982105834413 0.000116086212043485 NA NA NA hsa-miR-205-5p RELN 8.08298115900323 3.83045179398654e-07 -4.56675081618191 0.00128745672091879 miRNATAP -0.216062470150523 1.14909642981236e-05 NA NA NA hsa-miR-224-5p RELN 4.2725754042941 6.99983365278436e-06 -4.56675081618191 0.00128745672091879 MirTarget -0.323740417468779 0.000101545224499344 NA NA NA hsa-miR-27a-3p RELN 1.76094007417453 0.000216137556256765 -4.56675081618191 0.00128745672091879 MirTarget;miRNATAP -0.503343802206361 0.00304283134056195 NA NA NA hsa-miR-452-5p RELN 2.45466810475361 0.00114794259949532 -4.56675081618191 0.00128745672091879 MirTarget -0.310150091786342 0.00358752549845289 NA NA NA hsa-miR-590-3p RELN 2.35429565068338 2.79601879608564e-06 -4.56675081618191 0.00128745672091879 miRanda;miRNATAP -0.566409874491979 0.00037053749204621 NA NA NA hsa-miR-107 RPS6KB1 1.49443409571439 0.000130594521065411 0.147277461109991 0.600506468158798 PITA;miRanda -0.111469431880308 0.00608626394063609 NA NA NA hsa-miR-186-5p RPS6KB1 0.445443449112564 0.185447310527704 0.147277461109991 0.600506468158798 MirTarget;miRNATAP -0.188202471127657 8.10651969496359e-05 NA NA NA hsa-miR-125a-5p RPS6KB2 -1.32352790615388 0.00714301627309467 0.879028619054892 0.0118268028070626 miRanda -0.169895564703728 2.13927288529754e-05 NA NA NA hsa-miR-125a-3p SGK1 -0.0748960586927341 0.920735897434087 0.929366397812928 0.224785647813382 miRanda -0.175201072106353 0.00240706024786721 NA NA NA hsa-miR-217 SGK1 -0.378397407994341 0.717408682071252 0.929366397812928 0.224785647813382 miRanda -0.147167123392974 0.000395307539234144 NA NA NA hsa-miR-330-5p SGK2 2.25110496739954 0.000275527655397415 -0.810521799514785 0.558120705152807 miRanda -0.495272565700014 7.45774340368729e-05 NA NA NA hsa-miR-30a-5p SGK3 -0.768430903969183 0.320487552854215 -0.0210083296650621 0.957162794312302 miRNATAP -0.115204609815928 4.74707580157592e-05 NA NA NA hsa-miR-582-5p SGK3 0.685177900016753 0.447761540297692 -0.0210083296650621 0.957162794312302 miRNATAP -0.106417973718648 1.08653816661545e-05 NA NA NA hsa-miR-30b-5p SOS1 0.0238659735605804 0.953223658270319 -0.317916313975443 0.241700272513698 mirMAP -0.108560527488227 0.00434235766945579 NA NA NA hsa-miR-339-5p SOS1 1.23326828594484 0.0307501214818698 -0.317916313975443 0.241700272513698 miRNATAP -0.123853061266441 2.87456784370318e-06 NA NA NA hsa-let-7a-3p SOS2 0.82512001802525 0.0468122405194487 -0.267591445900317 0.496928330255155 miRNATAP -0.164368847616136 0.00237247406832302 NA NA NA hsa-miR-193a-3p SOS2 0.646392169474854 0.207134343676122 -0.267591445900317 0.496928330255155 PITA;miRanda;miRNATAP -0.120918057682943 0.00561915694088728 NA NA NA hsa-miR-590-3p SOS2 2.35429565068338 2.79601879608564e-06 -0.267591445900317 0.496928330255155 miRanda;mirMAP -0.188531608844422 1.41164746076931e-05 NA NA NA hsa-miR-590-5p SOS2 1.51400888103768 0.0023888567923017 -0.267591445900317 0.496928330255155 PITA;miRanda;miRNATAP -0.17241746507823 0.000101790255421271 NA NA NA hsa-miR-335-5p SPP1 0.167216045757305 0.803897055331049 2.62378012379966 0.0238129713516633 miRNAWalker2_validate -0.267186283709632 0.00657323488702888 NA NA NA hsa-miR-362-3p SPP1 0.679952485897744 0.226148468488576 2.62378012379966 0.0238129713516633 miRanda -0.392073615184002 0.000902670978383756 NA NA NA hsa-miR-542-3p SPP1 -0.376147863244659 0.438002751207043 2.62378012379966 0.0238129713516633 miRanda -0.410980003553363 0.00273549957767339 NA NA NA hsa-miR-330-3p STK11 2.49094236945806 0.000129367003214715 -0.26276893218333 0.64145996974596 mirMAP -0.180754893902168 0.000195158543898518 NA NA NA hsa-miR-330-5p STK11 2.25110496739954 0.000275527655397415 -0.26276893218333 0.64145996974596 miRanda -0.228906258010212 6.30285088801753e-06 NA NA NA hsa-miR-130a-5p SYK 1.58028512890005 0.024346333013728 2.89056220891182 2.98960233723338e-06 mirMAP -0.165924851646663 0.00126440958341574 NA NA NA hsa-miR-30a-3p SYK -1.22212086897848 0.167565797592104 2.89056220891182 2.98960233723338e-06 mirMAP -0.176540607684873 8.98748266883772e-06 NA NA NA hsa-miR-338-3p SYK 0.447551118940466 0.558485097370031 2.89056220891182 2.98960233723338e-06 miRanda -0.130881206052714 0.00497161018110646 NA NA NA hsa-miR-877-5p SYK 3.67317721493893 4.85916829184578e-06 2.89056220891182 2.98960233723338e-06 mirMAP -0.122262385577411 0.00556486262522001 NA NA NA hsa-miR-92b-3p SYK 1.69303761469782 0.0103484911955574 2.89056220891182 2.98960233723338e-06 mirMAP -0.152786621228821 0.00451128875980261 NA NA NA hsa-miR-99b-3p SYK 0.536537751808676 0.411976191991183 2.89056220891182 2.98960233723338e-06 miRNAWalker2_validate -0.304031234989171 1.35215012324498e-08 NA NA NA hsa-miR-940 TCL1A 3.78496690968119 4.75227557809023e-05 1.23316866585497 0.38309226483797 miRNATAP -0.332742572652977 0.00137219532085648 NA NA NA hsa-miR-140-3p TGFA -1.9828800596692 8.92876132959514e-08 3.46611624747303 7.88682746585729e-06 miRNATAP -0.475191560728835 6.49178380070972e-05 NA NA NA hsa-miR-181c-5p TGFA -0.302833440762172 0.537532549455539 3.46611624747303 7.88682746585729e-06 mirMAP -0.297511941715678 0.00113483703902286 NA NA NA hsa-miR-199a-5p TGFA -1.24888110793613 0.0747755616523728 3.46611624747303 7.88682746585729e-06 miRNATAP -0.185753940903155 0.00348509344333907 NA NA NA hsa-miR-28-5p TGFA -0.815636722979196 0.0221199948901761 3.46611624747303 7.88682746585729e-06 miRanda -0.795756877910187 1.34083585107169e-10 NA NA NA hsa-miR-29b-2-5p TGFA -0.596051745078872 0.189540844841389 3.46611624747303 7.88682746585729e-06 mirMAP -0.332023629987172 0.000785765693240545 NA NA NA hsa-let-7a-5p THBS1 0.148081801547773 0.645305441523746 -3.75129916683394 0.000103499881096753 miRNAWalker2_validate;TargetScan -0.497243904586914 0.00492292853577542 NA NA NA hsa-miR-16-1-3p THBS1 2.83281226969693 7.54359864580834e-09 -3.75129916683394 0.000103499881096753 MirTarget -0.643028399066049 3.09438933664662e-09 NA NA NA hsa-miR-17-5p THBS1 2.3269271449522 2.13987445663942e-05 -3.75129916683394 0.000103499881096753 miRNAWalker2_validate -0.267945077391595 0.00757970547802144 NA NA NA hsa-miR-182-5p THBS1 5.86988712704738 1.22411588571584e-15 -3.75129916683394 0.000103499881096753 MirTarget -0.241099584124763 0.000765040193303936 24053448 Effects of anti miR 182 on TSP 1 expression in human colon cancer cells: there is a sense in antisense?; We investigate on the molecular mechanism by which miR-182 could regulate thrombospondin-1 TSP-1 expression a protein downregulated in CRC and inversely correlated with tumor vascularity and metastasis; miR-182 over-expressed in colorectal cancer CRC has like predictive target thrombospondin-1 TSP-1 a protein inversely correlated with tumor vascularity and metastasis that results downregulated in different types of cancer including CRC; We found that TSP-1 increased after transfection with anti-miR-182 and we showed that miR-182 targets TSP-1 3'UTR-mRNA in both cells; Our data suggest that miR-182 targets the anti-angiogenic factor TSP-1 and that anti-miR-182 determines an upregulation of TSP-1 expression in colon cancer cells metastasis colon cancer hsa-miR-186-5p THBS1 0.445443449112564 0.185447310527704 -3.75129916683394 0.000103499881096753 mirMAP -0.462978112860335 0.00599316633809753 NA NA NA hsa-miR-19b-3p THBS1 1.67581705793313 0.000858910586302716 -3.75129916683394 0.000103499881096753 MirTarget;mirMAP -0.333448340944079 0.00241856130914615 NA NA NA hsa-miR-200a-5p THBS1 6.52092140839401 5.73108242597059e-22 -3.75129916683394 0.000103499881096753 MirTarget -0.485719624657622 5.54901388898712e-11 NA NA NA hsa-miR-200b-5p THBS1 6.81954246537908 6.31100593281326e-24 -3.75129916683394 0.000103499881096753 MirTarget -0.501001329221048 9.13787343375865e-12 NA NA NA hsa-miR-20a-5p THBS1 2.13553469875764 0.000181201072324354 -3.75129916683394 0.000103499881096753 miRNAWalker2_validate -0.307672252327679 0.00140150807491854 NA NA NA hsa-miR-3065-5p THBS1 2.14185373842821 0.0609400502269891 -3.75129916683394 0.000103499881096753 MirTarget -0.227705987060518 0.000143233633612563 NA NA NA hsa-miR-33a-3p THBS1 2.06269680799532 0.00156436055383943 -3.75129916683394 0.000103499881096753 MirTarget;mirMAP -0.24999380439174 0.00320886077009575 NA NA NA hsa-miR-375 THBS1 3.3784490463318 0.0449946294355695 -3.75129916683394 0.000103499881096753 miRanda -0.104064726462059 0.00140403889155616 NA NA NA hsa-miR-500a-5p THBS1 0.0170829425378565 0.973960207660626 -3.75129916683394 0.000103499881096753 mirMAP -0.360122797705364 0.000716954259923395 NA NA NA hsa-miR-576-5p THBS1 1.30320223793746 0.00648929463912994 -3.75129916683394 0.000103499881096753 mirMAP -0.371752416748424 0.00133090246897115 NA NA NA hsa-miR-590-3p THBS1 2.35429565068338 2.79601879608564e-06 -3.75129916683394 0.000103499881096753 miRanda -0.305195275125083 0.00517237635189344 NA NA NA hsa-miR-616-5p THBS1 2.48416313933027 0.00318247475868827 -3.75129916683394 0.000103499881096753 mirMAP -0.253411231221945 0.00197529844240196 NA NA NA hsa-miR-106a-5p THBS2 3.98693608217557 9.37722470816656e-07 -2.62795619060355 0.00635907547670508 MirTarget -0.336063474905193 2.56551669416365e-07 NA NA NA hsa-miR-106b-5p THBS2 2.80565545918114 1.14547999022566e-09 -2.62795619060355 0.00635907547670508 MirTarget -0.754072944240837 2.88430240077148e-11 NA NA NA hsa-miR-142-5p THBS2 3.95552531913424 1.49536283724079e-08 -2.62795619060355 0.00635907547670508 mirMAP -0.208949988681772 0.00645371511907511 NA NA NA hsa-miR-16-2-3p THBS2 3.79845098071094 1.49120139344659e-13 -2.62795619060355 0.00635907547670508 mirMAP -0.678064085425023 1.06849736981054e-11 NA NA NA hsa-miR-17-5p THBS2 2.3269271449522 2.13987445663942e-05 -2.62795619060355 0.00635907547670508 MirTarget;TargetScan -0.460832414079987 2.70142073659636e-06 NA NA NA hsa-miR-182-5p THBS2 5.86988712704738 1.22411588571584e-15 -2.62795619060355 0.00635907547670508 MirTarget;miRNATAP -0.185107388497314 0.00936294018881331 NA NA NA hsa-miR-20a-5p THBS2 2.13553469875764 0.000181201072324354 -2.62795619060355 0.00635907547670508 MirTarget -0.415858722079042 1.12986282215266e-05 NA NA NA hsa-miR-20b-5p THBS2 4.5662923200279 4.75238200639144e-05 -2.62795619060355 0.00635907547670508 MirTarget -0.199742215607688 2.8796635402953e-05 NA NA NA hsa-miR-32-3p THBS2 2.20477794939766 0.0392771274032852 -2.62795619060355 0.00635907547670508 miRNATAP -0.311183273683396 0.000549233998665121 NA NA NA hsa-miR-335-3p THBS2 1.19503568251824 0.0938852560631551 -2.62795619060355 0.00635907547670508 MirTarget;mirMAP -0.238234138626814 0.00191001264899203 NA NA NA hsa-miR-3614-5p THBS2 4.50236405439456 2.75644515847367e-07 -2.62795619060355 0.00635907547670508 miRNATAP -0.20657913597438 0.000767513919935484 NA NA NA hsa-miR-590-3p THBS2 2.35429565068338 2.79601879608564e-06 -2.62795619060355 0.00635907547670508 miRanda;mirMAP -0.366044680216134 0.000684664156327022 NA NA NA hsa-miR-590-5p THBS2 1.51400888103768 0.0023888567923017 -2.62795619060355 0.00635907547670508 miRanda -0.401872758797421 0.000247068390424525 NA NA NA hsa-miR-93-5p THBS2 2.65964181833033 2.58315947526774e-08 -2.62795619060355 0.00635907547670508 MirTarget -0.540936215734632 1.26073372180003e-06 NA NA NA hsa-miR-96-5p THBS2 5.62521466029286 1.54938806718028e-10 -2.62795619060355 0.00635907547670508 TargetScan;miRNATAP -0.298099877132397 5.09583790054224e-05 NA NA NA hsa-miR-550a-5p THBS3 1.21781238856895 0.0613791144699551 -1.57702454993947 0.000336933739949757 MirTarget -0.103051342949095 0.00766263723128083 NA NA NA hsa-miR-142-3p THBS4 4.35304505457969 3.10014573651358e-10 -4.07728930016853 0.00235648126729039 miRanda -0.355816324499892 0.000893784144159221 NA NA NA hsa-miR-320b THBS4 0.20205459771295 0.727216419960509 -4.07728930016853 0.00235648126729039 miRanda -0.376591407193519 0.0045449911696931 NA NA NA hsa-miR-320c THBS4 -0.10618808730545 0.854002814666472 -4.07728930016853 0.00235648126729039 miRanda -0.378120083552424 0.00534438405126932 NA NA NA hsa-miR-17-5p TLR4 2.3269271449522 2.13987445663942e-05 -2.5296024210219 0.000693676090265888 TargetScan -0.309964449647056 5.20636758104272e-05 NA NA NA hsa-miR-331-5p TLR4 1.02712086964089 0.0262526092356277 -2.5296024210219 0.000693676090265888 MirTarget -0.265788105596434 0.00415887752069142 NA NA NA hsa-miR-335-5p TLR4 0.167216045757305 0.803897055331049 -2.5296024210219 0.000693676090265888 miRNAWalker2_validate -0.187759001094844 0.00304485201336208 NA NA NA hsa-miR-338-3p TNN 0.447551118940466 0.558485097370031 0.143783378513697 0.900609654491326 miRanda -0.286691943183095 0.000749394423061437 NA NA NA hsa-miR-3607-3p TNXB 1.38015131722213 0.0240067155694847 -6.01533650902882 6.89214931831605e-10 miRNATAP -0.247732464811406 0.00782260922913917 NA NA NA hsa-miR-486-5p TNXB 1.10898145177457 0.309287974401609 -6.01533650902882 6.89214931831605e-10 miRanda -0.135833067627792 0.00912564383303178 NA NA NA hsa-miR-28-3p TSC1 -0.992446114847535 0.0188188359018203 -0.164264744382803 0.558456176869371 PITA -0.163451002258092 1.1903394911001e-05 NA NA NA hsa-miR-29a-5p TSC1 0.0748295222568571 0.884125894063293 -0.164264744382803 0.558456176869371 mirMAP -0.105441022835942 0.000632720914912164 NA NA NA hsa-miR-101-3p VEGFA -1.12421603598195 0.0200907284788457 -0.606702191559893 0.316325541201332 miRNAWalker2_validate -0.44049017437003 2.14988554587478e-10 NA NA NA hsa-miR-140-5p VEGFA -0.634610285725923 0.126670572966239 -0.606702191559893 0.316325541201332 miRNAWalker2_validate;miRTarBase;MirTarget;miRanda;miRNATAP -0.25107167892515 0.00261330338296037 26402430 MicroRNA 140 5p inhibits the progression of colorectal cancer by targeting VEGFA; The direct regulation of VEGFA by miR-140-5p was identified using luciferase reporter assay; Integrated analysis identified VEGFA as a direct and functional target gene of miR-140-5p; Silencing VEGFA by small interfering RNA siRNA resembled the phenotype resulting from ectopic miR-140-5p expression while overexpression of VEGFA attenuated the effect of miR-140-5p on CRC cells; Our results suggested a tumor suppressive role of miR-140-5p in CRC tumorigenesis and progression by targeting VEGFA progression;tumorigenesis colorectal cancer hsa-miR-145-5p VEGFA -3.55505374822025 5.45525288912869e-07 -0.606702191559893 0.316325541201332 miRNAWalker2_validate;miRTarBase -0.128423755259373 0.00677881518234136 24781864;24966896;22472569 Overexpression of miR-145 in thyroid cancer cell lines resulted in: decreased cell proliferation migration invasion VEGF secretion and E-cadherin expression; In vivo miR-145 overexpression decreased tumor growth and metastasis in a xenograft mouse model and VEGF secretion;The ectopic expression of miR-1 and miR-145 in NOZ cells significantly inhibited cell viability and colony formation P<0.01 and reduced gene expression of VEGF-A and AXL;Furthermore the results showed that vascular endothelial growth factor VEGF expression was down-regulated in osteosarcoma cells after miR-145 transfection; On the basis of these results we performed the luciferase assay and verified that miR-145 could down-regulate VEGF at the translational level by partially binding to VEGF 3' untranslated region 3'UTR; One of the mechanisms is the down-regulation of VEGF expression by miR-145 by binding to the 3'UTR of VEGF mRNA specifically metastasis;; thyroid cancer;bladder cancer;sarcoma hsa-miR-150-5p VEGFA 1.76769157530064 0.0593795975117846 -0.606702191559893 0.316325541201332 miRNAWalker2_validate;miRTarBase -0.190454559321715 1.05415152205695e-07 NA NA NA hsa-miR-195-5p VEGFA -1.59182537400701 0.0169128463756769 -0.606702191559893 0.316325541201332 miRNAWalker2_validate;miRTarBase;MirTarget -0.181624543409355 0.000381561947949573 27574422;23468064;26823724 In this study we used a new cationic peptide disulfide cross-linked stearylated polyarginine peptide modified with histidine H3R5 as a reducible vector cell penetrating peptide-modified aptamer ST21 with specific binding to HCC cells to conjugate to peptide H3R5 as the targeting probe miRNA-195 miR195 as a powerful gene drug to inhibit VEGF and fasudil to suppress vasculogenic mimicry by blocking ROCK2 all of which were simultaneously encapsulated in the same nanoparticles;Furthermore we revealed that miR-195 down-regulation resulted in enhanced VEGF levels in the tumor microenvironment which subsequently activated VEGF receptor 2 signaling in endothelial cells and thereby promoted angiogenesis;MiR 195 is a key negative regulator of hepatocellular carcinoma metastasis by targeting FGF2 and VEGFA; Luciferase reporter and ELISA assay prove that hematogenous metastasis related genes including FGF2 and VEGFA are the target genes of miR-195; Taken together our results suggest that miR-195 a tumor suppressor miRNA contributes to the lung metastasis of HCC by negatively regulating FGF2 and VEGFA providing key implications of miR-195 for the therapeutic intervention of HCC ;;metastasis liver cancer;liver cancer;liver cancer hsa-miR-199a-5p VEGFA -1.24888110793613 0.0747755616523728 -0.606702191559893 0.316325541201332 miRanda;miRNATAP -0.137846678781097 0.00478526288616186 25444917 In addition co-transfection with miR-199a mimic reversed the CCL5-mediated VEGF expression and angiogenesis in vitro and in vivo sarcoma hsa-miR-199b-5p VEGFA -0.53728867775768 0.476885702455766 -0.606702191559893 0.316325541201332 miRanda -0.179432408970336 6.95568617152433e-05 NA NA NA hsa-miR-29a-3p VEGFA -0.638239697975974 0.251923581881716 -0.606702191559893 0.316325541201332 MirTarget -0.17079026405468 0.00573296636369365 24209632 miR 29a suppresses growth and invasion of gastric cancer cells in vitro by targeting VEGF A; Furthermore western blot combined with the luciferase reporter assays demonstrate that vascular endothelial growth factor A VEGF-A is direct target of miR-29a; This is the first time miR-29a was found to suppress the tumor microvessel density in gastric cancer by targeting VEGF-A gastric cancer hsa-miR-29b-2-5p VEGFA -0.596051745078872 0.189540844841389 -0.606702191559893 0.316325541201332 MirTarget -0.280821422267245 0.000211600516233879 NA NA NA hsa-miR-29b-3p VEGFA 0.666547117072858 0.234055379278093 -0.606702191559893 0.316325541201332 miRNAWalker2_validate;miRTarBase;MirTarget -0.16053544503029 0.00905921871447091 26155940;22815235 Moreover miR-29b inhibits angiogenesis by attenuating tube formation and the expression of VEGF and Ang-2 and stemness maintenance in GBM cells as demonstrated by decreasing neurosphere formation and cancer stem cell marker protein expression;Additionally for two genes that are deregulated in PCa heterogeneous nuclear ribonucleoprotein K hnRNP-K and vascular endothelial growth factor A VEGF-A we identified two regulatory miRNAs miR-205 and miR-29b ; glioblastoma;prostate cancer hsa-miR-29c-3p VEGFA -0.414153610337085 0.529344128062017 -0.606702191559893 0.316325541201332 miRNAWalker2_validate;MirTarget -0.264648504422189 2.62132710063096e-07 NA NA NA hsa-miR-342-3p VEGFA 1.31107714473009 0.0207211910724662 -0.606702191559893 0.316325541201332 miRanda;miRNATAP -0.189890193502324 0.00167517321250592 23408138 Statistically significant associations were observed between miR-342 and ER HER2 and vascular endothelial growth factor VEGF status in the human breast cancer samples and the levels of miR-342 gradually increased as ERα mRNA expression increased breast cancer hsa-miR-497-5p VEGFA -1.44150596209372 0.0225146607606395 -0.606702191559893 0.316325541201332 MirTarget -0.20501977308518 0.000143045715274148 26718330;26485685;26336827;26202364;27015364;25176450;26840372 Furthermore western blot assay confirmed that the overexpression of miR-497 reduced VEGF and HIF-1α protein levels; Moreover miR-497 inhibited the growth of tumors and reduced angiogenesis in a nude mouse xenograft tumor model which was probably caused by the downregulation of pro-angiogenic molecules such as VEGF and HIF-1α;Role of miR 497 in VEGF A mediated cancer cell growth and invasion in non small cell lung cancer; Here we showed that compared to other cancers NSCLC had a significant higher ratio of VEGF-A protein vs mRNA and significantly lower levels of miR-497 suggesting presence of a post-transcriptional control of VEGF-A in NSCLC different from other cancers; Compared with paired normal lung tissue NSCLC expressed lower levels of miR-497 and higher levels of VEGF-A; Moreover the levels of miR-497 and VEGF-A were inversely correlated in NSCLC specimen; Bioinformatics analyses showed that miR-497 bound to 3'-UTR of VEGF-A mRNA in NSCLC lines to inhibit its translation; Overexpression of miR-497 in NSCLC lines decreased VEGF-A protein while depletion of miR-497 in NSCLC lines increased VEGF-A protein; However modification of miR-497 levels in NSCLC lines did not alter VEGF-A mRNA levels;MiR 497 suppresses angiogenesis and metastasis of hepatocellular carcinoma by inhibiting VEGFA and AEG 1; Subsequent investigations disclosed that miR-497 directly inhibited the 3'-untranslated regions UTRs of vascular endothelial growth factor A VEGFA and astrocyte elevated gene-1 AEG-1;The effects of ectopic miR-497 expression on the expression of VEGFA Akt and p-Akt were determined by western blot; Luciferase reporter assay and western blot confirmed that VEGFA was a direct target of miR-497;Subsequent investigations disclosed that Twist was regulated by miR-497 directly leading to the increased level of Vascular Endothelial Growth Factor-A VEGFA;We further disclosed that miR-497 exerted its function of anti-angiogenesis by suppressing VEGFA expression in ovarian cancer cells and in turn impairing the VEGFR2-mediated PI3K/AKT and MAPK/ERK pathways;Vascular endothelial growth factor-A VEGF-A was confirmed to be a target of miR-497 ;;metastasis;;;; breast cancer;lung squamous cell cancer;liver cancer;sarcoma;pancreatic cancer;ovarian cancer;colorectal cancer hsa-miR-16-2-3p VEGFC 3.79845098071094 1.49120139344659e-13 -2.61199123014623 0.00786293959867815 MirTarget -0.523426860787708 4.20594096318382e-07 NA NA NA hsa-miR-15a-5p VWF 2.0535411006904 1.91108976398046e-06 -3.42077216872826 7.3563996629188e-08 mirMAP -0.338906116274972 5.79194827871892e-05 NA NA NA hsa-miR-15b-5p VWF 3.32329949959268 8.40210501034588e-13 -3.42077216872826 7.3563996629188e-08 mirMAP -0.481328940304442 1.19557042925501e-10 NA NA NA hsa-miR-16-5p VWF 2.93575808220754 2.15436817162977e-10 -3.42077216872826 7.3563996629188e-08 mirMAP -0.478597301538174 2.81393023670706e-10 NA NA NA hsa-miR-429 VWF 6.39965293994036 1.96920201593608e-18 -3.42077216872826 7.3563996629188e-08 miRNATAP -0.237923858571963 3.65397663764324e-07 NA NA NA hsa-miR-181c-5p YWHAB -0.302833440762172 0.537532549455539 0.335869051616385 0.183059097452288 mirMAP -0.125689817265884 1.28469508387139e-05 NA NA NA hsa-miR-181c-5p YWHAG -0.302833440762172 0.537532549455539 0.385447226562581 0.259836541396253 MirTarget;miRNATAP -0.154303477041672 8.85668622972177e-05 NA NA NA hsa-miR-200a-3p YWHAG 6.336081120041 4.024313571871e-16 0.385447226562581 0.259836541396253 MirTarget;miRNATAP -0.102315490044077 1.13196642995869e-05 NA NA NA hsa-miR-200b-3p YWHAG 5.56167217794639 6.43540045061709e-16 0.385447226562581 0.259836541396253 MirTarget;TargetScan -0.11446043266416 1.4853090925883e-05 NA NA NA hsa-miR-30a-5p YWHAG -0.768430903969183 0.320487552854215 0.385447226562581 0.259836541396253 miRNATAP -0.121044963221771 8.71646064734457e-07 NA NA NA hsa-miR-361-3p YWHAG 0.805698609170807 0.0418491665498322 0.385447226562581 0.259836541396253 miRNATAP -0.158816170102406 0.00125725402796885 NA NA NA hsa-miR-103a-3p YWHAH 0.990919087251708 0.00468308601422847 0.13374017455715 0.582343790497203 miRNAWalker2_validate;MirTarget;miRNATAP -0.118934118915957 0.00255872843635267 NA NA NA hsa-miR-125a-5p YWHAZ -1.32352790615388 0.00714301627309467 0.79320742951499 0.0165264552158362 miRanda -0.201268409816025 8.09227898128116e-08 NA NA NA hsa-miR-140-3p YWHAZ -1.9828800596692 8.92876132959514e-08 0.79320742951499 0.0165264552158362 MirTarget;PITA;miRNATAP -0.209328588960889 2.6752974302612e-05 NA NA NA hsa-miR-186-5p YWHAZ 0.445443449112564 0.185447310527704 0.79320742951499 0.0165264552158362 mirMAP -0.186541881236864 0.00102158968605537 NA NA NA hsa-miR-195-3p YWHAZ -2.39100534119332 0.000185405399054065 0.79320742951499 0.0165264552158362 MirTarget -0.10349718609516 0.00037684292135237 NA NA NA hsa-miR-28-5p YWHAZ -0.815636722979196 0.0221199948901761 0.79320742951499 0.0165264552158362 PITA;miRanda;miRNATAP -0.246603493589959 3.00364263847771e-06 NA NA NA hsa-miR-30a-5p YWHAZ -0.768430903969183 0.320487552854215 0.79320742951499 0.0165264552158362 miRNAWalker2_validate;MirTarget;miRNATAP -0.114377769916144 1.71880952710236e-06 NA NA NA hsa-miR-328-3p YWHAZ -0.405365328300136 0.434443269076833 0.79320742951499 0.0165264552158362 MirTarget -0.13309401279703 0.000234142058366856 NA NA NA hsa-miR-3913-5p YWHAZ 0.145645056779437 0.734844256690741 0.79320742951499 0.0165264552158362 MirTarget -0.204232871287809 2.79795865642911e-06 NA NA NA hsa-miR-7-1-3p YWHAZ 1.43074343339835 0.00471215970502094 0.79320742951499 0.0165264552158362 mirMAP -0.120732639494573 0.00108325254319048 NA NA NA