miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-18a-5p ABR 0.969066793715868 1.69069796425892e-08 -0.212735144817199 0.000363418048922686 miRNAWalker2_validate;mirMAP -0.109068853724789 3.43667008155402e-21 NA NA NA hsa-miR-18a-5p ADAMTS2 0.969066793715868 1.69069796425892e-08 -0.221073363602919 0.172799998721038 mirMAP -0.151270479965282 2.23092352991542e-06 NA NA NA hsa-miR-18a-5p AFF4 0.969066793715868 1.69069796425892e-08 -0.281510843525455 0.00153080576834839 miRNAWalker2_validate -0.216780642407195 5.47601743907678e-38 NA NA NA hsa-miR-18a-5p ALCAM 0.969066793715868 1.69069796425892e-08 0.50501413295289 0.00106417407883302 MirTarget;miRNATAP -0.342138218282154 4.63746773220129e-31 NA NA NA hsa-miR-18a-5p ANKRD50 0.969066793715868 1.69069796425892e-08 0.253781836442069 0.0223096878521534 MirTarget;miRNATAP -0.177741763059093 2.01514957148336e-16 NA NA NA hsa-miR-18a-5p APOLD1 0.969066793715868 1.69069796425892e-08 -1.79825454034465 2.31789749575749e-44 mirMAP -0.158264613633656 3.21161314972337e-09 NA NA NA hsa-miR-18a-5p ARFGEF2 0.969066793715868 1.69069796425892e-08 -0.00379293152990279 0.966707448870531 MirTarget -0.121111361663676 9.26771791125924e-12 NA NA NA hsa-miR-18a-5p ARHGAP5 0.969066793715868 1.69069796425892e-08 -0.905445537339626 5.67397960745221e-22 MirTarget -0.116582874797694 7.2816059600348e-10 NA NA NA hsa-miR-18a-5p ARL15 0.969066793715868 1.69069796425892e-08 -0.940546011404162 6.29941456769943e-17 MirTarget;miRNATAP -0.256659599347071 8.53689264458731e-32 NA NA NA hsa-miR-18a-5p ASTN1 0.969066793715868 1.69069796425892e-08 -2.96085678510482 6.59267881470187e-30 MirTarget -0.24658682628591 3.80944772672986e-06 NA NA NA hsa-miR-18a-5p ASXL2 0.969066793715868 1.69069796425892e-08 -0.863091823045132 1.23718078543405e-08 miRNATAP -0.172959671290264 8.68420972604786e-09 NA NA NA hsa-miR-18a-5p ATF7 0.969066793715868 1.69069796425892e-08 -0.8075699517726 1.70008219567476e-38 mirMAP -0.135353522649776 2.5614664515906e-27 NA NA NA hsa-miR-18a-5p ATM 0.969066793715868 1.69069796425892e-08 -0.753520785022149 8.14866377341274e-18 miRNAWalker2_validate;miRTarBase;MirTarget -0.116309277677122 3.16867464269194e-11 23857602;23437304;25963391;23229340 Furthermore we used antisense oligonucleotides against micro RNAs miRNA or miRNA overexpression plasmids to study the role of miR-18a and -106a on ATM expression; Furthermore we identified that ERα activates miR-18a and -106a to downregulate ATM expression; We reveal a novel mechanism involving ERα and miR-18a and -106a regulation of ATM in breast cancer;MicroRNA 18a attenuates DNA damage repair through suppressing the expression of ataxia telangiectasia mutated in colorectal cancer; Through in silico search the 3'UTR of Ataxia telangiectasia mutated ATM contains a conserved miR-18a binding site; Expression of ATM was down-regulated in CRC tumors p<0.0001 and inversely correlated with miR-18a expression r = -0.4562 p<0.01; This was further confirmed by the down-regulation of ATM protein by miR-18a; As ATM is a key enzyme in DNA damage repair we evaluated the effect of miR-18a on DNA double-strand breaks; miR-18a attenuates cellular repair of DNA double-strand breaks by directly suppressing ATM a key enzyme in DNA damage repair;However the upregulation of miR-18a suppressed the level of ataxia-telangiectasia mutated and attenuated DNA double-strand break repair after irradiation which re-sensitized the cervical cancer cells to radiotherapy by promoting apoptosis;MicroRNA 18a upregulates autophagy and ataxia telangiectasia mutated gene expression in HCT116 colon cancer cells; Previous studies showed that certain microRNAs including miR-18a potentially regulate ATM in cancer cells; However the mechanisms behind the modulation of ATM by miR-18a remain to be elucidated in colon cancer cells; In the present study we explored the impact of miR-18a on the autophagy process and ATM expression in HCT116 colon cancer cells; Western blotting and luciferase assays were implemented to explore the impact of miR-18a on ATM gene expression in HCT116 cells; Moreover miR-18a overexpression led to the upregulation of ATM expression and suppression of mTORC1 activity; Results of the present study pertaining to the role of miR-18a in regulating autophagy and ATM gene expression in colon cancer cells revealed a novel function for miR-18a in a critical cellular event and on a crucial gene with significant impacts in cancer development progression treatment and in other diseases ;;;progression breast cancer;colorectal cancer;cervical and endocervical cancer;colon cancer hsa-miR-18a-5p ATP1B2 0.969066793715868 1.69069796425892e-08 -1.90231916229878 1.04585268498219e-40 mirMAP -0.227686734467817 6.54947879295752e-15 NA NA NA hsa-miR-18a-5p ATP2B1 0.969066793715868 1.69069796425892e-08 -0.637952928825792 3.60512245786879e-13 miRNATAP -0.120983732791358 3.71397545202766e-12 NA NA NA hsa-miR-18a-5p ATP2C2 0.969066793715868 1.69069796425892e-08 1.76106628615016 3.59105374394742e-19 MirTarget -0.198572649927767 5.57829579300383e-07 NA NA NA hsa-miR-18a-5p ATXN1 0.969066793715868 1.69069796425892e-08 -0.114435417261807 0.172447028305803 MirTarget;miRNATAP -0.158757938966941 9.08602732129693e-23 NA NA NA hsa-miR-18a-5p BBX 0.969066793715868 1.69069796425892e-08 -0.606457956375014 6.12159507795877e-13 MirTarget;miRNATAP -0.107164441129034 1.56844778188935e-10 NA NA NA hsa-miR-18a-5p BHLHE22 0.969066793715868 1.69069796425892e-08 -0.885533409707188 1.61361696091456e-08 MirTarget;miRNATAP -0.102847395049489 0.00101179851804635 NA NA NA hsa-miR-18a-5p C1orf21 0.969066793715868 1.69069796425892e-08 -0.468027970401431 0.00105985509741778 mirMAP -0.352380566715628 9.90850405457288e-39 NA NA NA hsa-miR-18a-5p C1orf226 0.969066793715868 1.69069796425892e-08 -0.372381264122664 0.0272316478618929 mirMAP -0.288803056276439 1.14096045122522e-18 NA NA NA hsa-miR-18a-5p C5orf30 0.969066793715868 1.69069796425892e-08 0.367235127176674 0.00227287955218659 miRNATAP -0.221817652321724 1.71205775534449e-21 NA NA NA hsa-miR-18a-5p CA12 0.969066793715868 1.69069796425892e-08 1.1080341989271 2.19542324257114e-05 miRNAWalker2_validate;MirTarget -0.845217777323844 1.2280252750954e-70 NA NA NA hsa-miR-18a-5p CACNG4 0.969066793715868 1.69069796425892e-08 2.21159891256783 3.76360584804154e-13 mirMAP -0.479660977852052 1.65065818706956e-15 NA NA NA hsa-miR-18a-5p CALN1 0.969066793715868 1.69069796425892e-08 -2.70813184176793 2.87746517163719e-26 mirMAP -0.423327540543552 1.61797555803963e-16 NA NA NA hsa-miR-18a-5p CAMK2B 0.969066793715868 1.69069796425892e-08 -0.00506231354389119 0.984198517683776 mirMAP -0.272652665944852 5.85107409807785e-08 NA NA NA hsa-miR-18a-5p CAMK2N1 0.969066793715868 1.69069796425892e-08 0.270123856938859 0.0766724015071091 miRNATAP -0.297143132124591 5.13523150174157e-24 NA NA NA hsa-miR-18a-5p CASZ1 0.969066793715868 1.69069796425892e-08 0.650698025577658 4.38286118706725e-10 mirMAP -0.224148052389293 1.08753977757912e-28 NA NA NA hsa-miR-18a-5p CDON 0.969066793715868 1.69069796425892e-08 -0.991164686357028 8.70119211480039e-13 mirMAP -0.269832410713206 2.46101550483186e-23 NA NA NA hsa-miR-18a-5p CLASP2 0.969066793715868 1.69069796425892e-08 -0.480530283040537 1.81219003638834e-11 miRNATAP -0.144015352857882 3.91095997033606e-25 NA NA NA hsa-miR-18a-5p CREBL2 0.969066793715868 1.69069796425892e-08 -0.828924810318552 7.72831390224407e-35 miRNAWalker2_validate;MirTarget;miRNATAP -0.18688020696653 6.39009893275456e-46 NA NA NA hsa-miR-18a-5p CRIM1 0.969066793715868 1.69069796425892e-08 -2.02664077447827 3.91244764943777e-56 MirTarget;miRNATAP -0.268538776483512 4.74205100277358e-24 NA NA NA hsa-miR-18a-5p CSNK1G1 0.969066793715868 1.69069796425892e-08 0.253700287809945 0.00027435091852733 mirMAP -0.107632067902284 2.58794384497738e-15 NA NA NA hsa-miR-18a-5p CSRNP3 0.969066793715868 1.69069796425892e-08 -3.01553219063623 2.41616502431045e-41 miRNAWalker2_validate;miRNATAP -0.362405771137282 3.19672029425217e-15 NA NA NA hsa-miR-18a-5p CTDSPL 0.969066793715868 1.69069796425892e-08 -0.590202944121454 1.39580025090321e-17 miRNAWalker2_validate;MirTarget;miRNATAP -0.158588848975107 3.51928970904997e-32 NA NA NA hsa-miR-18a-5p CTGF 0.969066793715868 1.69069796425892e-08 -0.492053877527233 0.000535095367324139 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.119846814285957 2.0448230920207e-05 23249750 Targeting of TGFβ signature and its essential component CTGF by miR 18 correlates with improved survival in glioblastoma; Indeed microRNA-18a but not other miR-17∼92 members has a functional site in the CTGF 3' UTR and its forced reexpression sharply reduces CTGF protein and mRNA levels; The unexpected effects of miR-18a on CTGF transcription are mediated in part by direct targeting of Smad3 and ensuing weakening of TGFβ signaling poor survival glioblastoma hsa-miR-18a-5p CYP4F11 0.969066793715868 1.69069796425892e-08 0.473537452647952 0.145608198824884 MirTarget -0.608616466590783 3.56154348444121e-22 NA NA NA hsa-miR-18a-5p DAAM2 0.969066793715868 1.69069796425892e-08 -1.92805635027671 2.37223617810461e-48 miRNAWalker2_validate -0.128936539387179 3.13505694340858e-06 NA NA NA hsa-miR-18a-5p DCUN1D3 0.969066793715868 1.69069796425892e-08 -1.06136698889532 1.78469564912163e-54 miRNAWalker2_validate -0.11981287755687 3.22327193832774e-17 NA NA NA hsa-miR-18a-5p DICER1 0.969066793715868 1.69069796425892e-08 -0.485751118977791 3.51736049886836e-09 miRNAWalker2_validate -0.136912050395007 2.01038095738162e-17 27338043;21935572 MiR 18a upregulation decreases Dicer expression and confers paclitaxel resistance in triple negative breast cancer; In this study we investigated the association among miR-18a dysregulation Dicer dysregulation and paclitaxel PTX resistance in TNBC cells; The influence of miR-18a overexpression on Dicer expression was measured by qRT-PCR and Western blot analysis; MiR-18a overexpression directly led to Dicer repression at mRNA and protein level; This study found that miR-18a is an important miRNA that suppresses Dicer expression and increases PTX resistance in TNBC cells;microRNA 18a a member of the oncogenic miR 17 92 cluster targets Dicer and suppresses cell proliferation in bladder cancer T24 cells; Furthermore ectopic expression of miR-18a in T24 cells down-regulated Dicer expression at both the mRNA and protein level while inhibition miR-18a by antisense oligonucleotides could enhance Dicer expression in T24 cells; Two binding sites of miR-18a were found in Dicer 3' untranslated region 3' UTR; In addition knockdown of Dicer expression by siRNA mimicked cell growth suppression induced by miR-18a in T24 cells; These results show that miR-18a functions as a tumor suppressor by targeting Dicer in bladder cancer T24 cells and revealed a noteworthy feedback loop which may be utilized by the miR-17-92 cluster to control miRNA output and prevent its overexpression drug resistance; breast cancer;bladder cancer hsa-miR-18a-5p DNAJC16 0.969066793715868 1.69069796425892e-08 -0.0177287978055789 0.789699458393739 MirTarget -0.154106968328649 2.07514991406951e-34 NA NA NA hsa-miR-18a-5p DOCK4 0.969066793715868 1.69069796425892e-08 -0.955337759049208 3.43382447572213e-22 MirTarget -0.105041741749793 1.36108409679642e-07 NA NA NA hsa-miR-18a-5p DPY19L3 0.969066793715868 1.69069796425892e-08 -0.0882358035386357 0.476872140641766 MirTarget -0.1842473421487 2.56869719979074e-14 NA NA NA hsa-miR-18a-5p DST 0.969066793715868 1.69069796425892e-08 -2.65768728199613 1.49859497194328e-82 mirMAP -0.253594711302634 1.70338130586849e-17 NA NA NA hsa-miR-18a-5p ESR1 0.969066793715868 1.69069796425892e-08 0.349232651607838 0.313942462521254 miRNAWalker2_validate;miRTarBase;miRNATAP -1.14044745041939 3.5647791599912e-74 19027010;24975878 MicroRNA 18a prevents estrogen receptor alpha expression promoting proliferation of hepatocellular carcinoma cells; The gene ESR1 which encodes the estrogen receptor-alpha ERalpha was identified as a target of miR-18a miR-18a can repress ERalpha translation by binding to its mRNA at the 3' untranslated region;Elevated p53 promotes the processing of miR 18a to decrease estrogen receptor α in female hepatocellular carcinoma; Our previous study identified that estrogen receptor alpha ERα protein is downregulated in 60% of female HCC cases via a miR-18a elevation mediated suppression of ERα translation ; liver cancer;liver cancer hsa-miR-18a-5p F3 0.969066793715868 1.69069796425892e-08 -2.18337486686632 5.89270776390065e-40 MirTarget -0.22259238842336 5.95650101731875e-11 NA NA NA hsa-miR-18a-5p FAIM2 0.969066793715868 1.69069796425892e-08 -0.153328534808712 0.529442614210649 mirMAP -0.36753895081149 1.06119137499698e-14 NA NA NA hsa-miR-18a-5p FAM166B 0.969066793715868 1.69069796425892e-08 -2.33933260072328 5.53088134929359e-28 MirTarget -0.142348737056905 0.00112263071949073 NA NA NA hsa-miR-18a-5p FAM168A 0.969066793715868 1.69069796425892e-08 -0.595647286022841 1.59492655064768e-06 mirMAP -0.123229308838653 5.4509195026933e-07 NA NA NA hsa-miR-18a-5p FAM196A 0.969066793715868 1.69069796425892e-08 1.98296570560131 3.09651461409495e-10 MirTarget -0.558344683915752 1.52927869844399e-19 NA NA NA hsa-miR-18a-5p FBP1 0.969066793715868 1.69069796425892e-08 0.939517939445725 1.73181954211772e-07 MirTarget -0.497445174576123 3.83311300421063e-49 NA NA NA hsa-miR-18a-5p FEM1C 0.969066793715868 1.69069796425892e-08 -0.260293397561805 0.000498044801322955 miRNAWalker2_validate -0.173013762406906 5.3483165847e-34 NA NA NA hsa-miR-18a-5p FGF1 0.969066793715868 1.69069796425892e-08 -2.3363200609921 2.42261900591497e-58 MirTarget -0.308725947141596 9.70167258927243e-25 NA NA NA hsa-miR-18a-5p FNDC3A 0.969066793715868 1.69069796425892e-08 -0.66982003024733 3.15148821702158e-17 miRNATAP -0.147319318642176 4.56307201490207e-21 NA NA NA hsa-miR-18a-5p FRS2 0.969066793715868 1.69069796425892e-08 -0.151534815530378 0.172700768380748 MirTarget -0.257900743959529 2.45547348306966e-34 NA NA NA hsa-miR-18a-5p FRYL 0.969066793715868 1.69069796425892e-08 -0.526094879952545 1.15146203194162e-10 miRNATAP -0.14842902721644 1.40370457600511e-20 NA NA NA hsa-miR-18a-5p GAB1 0.969066793715868 1.69069796425892e-08 -0.692166188366933 9.18798859765721e-16 MirTarget;miRNATAP -0.178021538614324 3.83791153370437e-26 NA NA NA hsa-miR-18a-5p GAS7 0.969066793715868 1.69069796425892e-08 -1.14456976255473 3.24757711318389e-18 mirMAP -0.257144385360811 3.25646718719617e-23 NA NA NA hsa-miR-18a-5p GLRB 0.969066793715868 1.69069796425892e-08 -0.872693598352434 7.45815381736751e-06 MirTarget;miRNATAP -0.420712583557575 2.92416921018491e-29 NA NA NA hsa-miR-18a-5p GNA11 0.969066793715868 1.69069796425892e-08 -0.413243450071525 7.72784254932992e-06 MirTarget -0.131470047953861 4.21510730519923e-13 NA NA NA hsa-miR-18a-5p GNG7 0.969066793715868 1.69069796425892e-08 -1.27893544175867 1.22567787829192e-21 mirMAP -0.102334215711126 0.000163584996294418 NA NA NA hsa-miR-18a-5p GNPDA2 0.969066793715868 1.69069796425892e-08 -0.507964543736103 6.94366083240274e-11 MirTarget -0.137411618557432 2.11305820150809e-19 NA NA NA hsa-miR-18a-5p GTF2A1 0.969066793715868 1.69069796425892e-08 -0.707406837538239 1.08698731198543e-05 MirTarget -0.208023597477171 5.11466996053174e-11 NA NA NA hsa-miR-18a-5p H6PD 0.969066793715868 1.69069796425892e-08 -0.858645530203666 1.48469482405532e-35 mirMAP -0.126944181339438 8.99389486725863e-20 NA NA NA hsa-miR-18a-5p HERC1 0.969066793715868 1.69069796425892e-08 -0.881913488633341 4.06571170612415e-28 miRNAWalker2_validate -0.166678978204255 1.41603516627385e-25 NA NA NA hsa-miR-18a-5p HIPK2 0.969066793715868 1.69069796425892e-08 -0.953765945586234 3.35720241682395e-14 mirMAP -0.116154083309191 4.06313103703854e-06 NA NA NA hsa-miR-18a-5p HLF 0.969066793715868 1.69069796425892e-08 -3.73360626511854 1.05238992329545e-69 MirTarget -0.226586768681528 6.54880708946071e-07 NA NA NA hsa-miR-18a-5p HMBOX1 0.969066793715868 1.69069796425892e-08 -0.729256061931685 4.98979109584954e-11 MirTarget;miRNATAP -0.21100115910716 2.13179784211135e-22 NA NA NA hsa-miR-18a-5p HOXA9 0.969066793715868 1.69069796425892e-08 -2.51701243665575 2.02680334794481e-43 miRNAWalker2_validate -0.190067368057164 5.3489040580045e-07 NA NA NA hsa-miR-18a-5p IGFBP5 0.969066793715868 1.69069796425892e-08 -0.624288440197653 0.00100115978565398 mirMAP -0.225414876847806 1.60030082423832e-09 NA NA NA hsa-miR-18a-5p IL17B 0.969066793715868 1.69069796425892e-08 -3.18394317299078 2.55287692402965e-31 MirTarget -0.280256674044975 5.69689446160658e-07 NA NA NA hsa-miR-18a-5p ITGA2 0.969066793715868 1.69069796425892e-08 -0.578073454534045 0.000245362336210971 MirTarget -0.277288585922338 1.4587093955565e-19 NA NA NA hsa-miR-18a-5p KCNA1 0.969066793715868 1.69069796425892e-08 -2.92558361314474 6.5800868813974e-30 MirTarget;miRNATAP -0.365812218557213 2.64695980468239e-12 NA NA NA hsa-miR-18a-5p KIF13B 0.969066793715868 1.69069796425892e-08 -0.34768873706652 0.0092559287339681 mirMAP -0.42694013307171 4.05713490942489e-69 NA NA NA hsa-miR-18a-5p LONP2 0.969066793715868 1.69069796425892e-08 -0.100335281095472 0.260190278648596 mirMAP -0.13034580866847 6.3129851607025e-14 NA NA NA hsa-miR-18a-5p LONRF2 0.969066793715868 1.69069796425892e-08 -0.371952863448676 0.158204061980662 mirMAP -0.656490113300794 9.01275306546033e-40 NA NA NA hsa-miR-18a-5p LPP 0.969066793715868 1.69069796425892e-08 -1.17035459588915 3.47523383485479e-19 mirMAP -0.200432677688042 1.54370427595509e-14 NA NA NA hsa-miR-18a-5p LRP10 0.969066793715868 1.69069796425892e-08 -0.0382360620439677 0.56834890677188 mirMAP -0.193626966923308 2.71454814841761e-55 NA NA NA hsa-miR-18a-5p MAN2B2 0.969066793715868 1.69069796425892e-08 0.103655071752021 0.154117977539973 mirMAP -0.203760849703937 1.573557107246e-51 NA NA NA hsa-miR-18a-5p MAP3K1 0.969066793715868 1.69069796425892e-08 -0.163521491329447 0.167268025811007 miRNATAP -0.316610440339497 2.14317799336319e-46 NA NA NA hsa-miR-18a-5p MDGA1 0.969066793715868 1.69069796425892e-08 -0.0639263710072093 0.639909371226836 miRNATAP -0.200479649226778 5.41840066449566e-14 NA NA NA hsa-miR-18a-5p MEF2C 0.969066793715868 1.69069796425892e-08 -1.3628193091141 3.63471865869307e-46 MirTarget -0.127566112747227 1.28918194375564e-10 NA NA NA hsa-miR-18a-5p MEF2D 0.969066793715868 1.69069796425892e-08 0.131564527494279 0.0295640483901206 miRNATAP -0.13204707652659 2.29150705324917e-30 NA NA NA hsa-miR-18a-5p MPPED2 0.969066793715868 1.69069796425892e-08 -1.92995077631031 1.27147853851054e-23 mirMAP -0.210280450250362 7.08623181228274e-08 NA NA NA hsa-miR-18a-5p MTHFR 0.969066793715868 1.69069796425892e-08 -0.0001383017090415 0.998720202441913 mirMAP -0.1679667982994 4.02543773165036e-24 NA NA NA hsa-miR-18a-5p NBEA 0.969066793715868 1.69069796425892e-08 -0.839776830944797 1.66396522124089e-06 miRNAWalker2_validate -0.528982821660413 7.82609567879678e-60 NA NA NA hsa-miR-18a-5p NCOA1 0.969066793715868 1.69069796425892e-08 -0.712218181034353 8.49003995158387e-25 MirTarget;miRNATAP -0.134970373152042 9.83382622027132e-23 NA NA NA hsa-miR-18a-5p NEDD4 0.969066793715868 1.69069796425892e-08 -0.630802490935963 7.76484838971521e-11 MirTarget;miRNATAP -0.237772989643153 1.33736803467272e-37 NA NA NA hsa-miR-18a-5p NEDD9 0.969066793715868 1.69069796425892e-08 -1.52910128564144 4.88149738943635e-34 miRTarBase;MirTarget;miRNATAP -0.200054503528031 5.0385866880316e-15 22308110 NEDD9 and CDK19 were identified as novel miR-18a targets and were shown to be pro-proliferative genes with RNA interference of their transcripts decreasing proliferation in CRC cells colorectal cancer hsa-miR-18a-5p NHLRC2 0.969066793715868 1.69069796425892e-08 -0.675891798900443 6.43662292606437e-09 mirMAP -0.160538006387603 2.85525253960548e-12 NA NA NA hsa-miR-18a-5p NR3C1 0.969066793715868 1.69069796425892e-08 -1.90095759546805 1.53460991213052e-74 miRNAWalker2_validate;miRTarBase;miRNATAP -0.16520939885116 1.39190676142027e-13 NA NA NA hsa-miR-18a-5p NRG1 0.969066793715868 1.69069796425892e-08 -2.72776391585681 2.94582737368582e-26 miRNATAP -0.243721864987581 3.32805830007628e-06 NA NA NA hsa-miR-18a-5p NTRK3 0.969066793715868 1.69069796425892e-08 -2.79779489905708 1.23029392356612e-24 mirMAP -0.221782427020024 6.64375802513301e-05 NA NA NA hsa-miR-18a-5p OLFML2A 0.969066793715868 1.69069796425892e-08 -1.23279838858358 1.44822780058179e-34 mirMAP -0.195371289535398 5.30593895273794e-22 NA NA NA hsa-miR-18a-5p ORAI3 0.969066793715868 1.69069796425892e-08 0.344340219100835 4.58926338324289e-05 miRNAWalker2_validate;miRNATAP -0.17646569687491 1.83610431856552e-27 NA NA NA hsa-miR-18a-5p PAPPA 0.969066793715868 1.69069796425892e-08 -0.728679548360849 1.50074730316036e-06 miRNATAP -0.131810384950291 1.17242589142028e-05 NA NA NA hsa-miR-18a-5p PARD6B 0.969066793715868 1.69069796425892e-08 1.70997497031339 2.55366919190462e-20 miRNAWalker2_validate;MirTarget -0.284811022335125 1.39901909644042e-14 NA NA NA hsa-miR-18a-5p PCBD2 0.969066793715868 1.69069796425892e-08 0.254893330287496 0.000606273909609041 mirMAP -0.147378285611701 7.88716172628899e-25 NA NA NA hsa-miR-18a-5p PCDHGA10 0.969066793715868 1.69069796425892e-08 -1.1032432713533 2.33889510866597e-07 mirMAP -0.242139355042132 1.00366706189103e-08 NA NA NA hsa-miR-18a-5p PCDHGA12 0.969066793715868 1.69069796425892e-08 -1.21599251115806 1.44246526771226e-11 mirMAP -0.232968463381782 7.18619587742436e-11 NA NA NA hsa-miR-18a-5p PCDHGA2 0.969066793715868 1.69069796425892e-08 -2.53454953770495 2.5559414287724e-33 mirMAP -0.393699736732539 2.07049087605291e-20 NA NA NA hsa-miR-18a-5p PCDHGA3 0.969066793715868 1.69069796425892e-08 -2.34677567765991 1.85629227002049e-40 mirMAP -0.310939315331092 5.85295983356843e-18 NA NA NA hsa-miR-18a-5p PCDHGA4 0.969066793715868 1.69069796425892e-08 -1.78538346326217 1.53018321609373e-18 mirMAP -0.270711505047657 2.8894474513565e-11 NA NA NA hsa-miR-18a-5p PCDHGA5 0.969066793715868 1.69069796425892e-08 -1.89554832995795 1.92381404032939e-21 mirMAP -0.331952352035761 7.19409680481861e-17 NA NA NA hsa-miR-18a-5p PCDHGA6 0.969066793715868 1.69069796425892e-08 -1.8070193866698 6.08773636456156e-28 mirMAP -0.2355442960291 1.71995216927291e-12 NA NA NA hsa-miR-18a-5p PCDHGA7 0.969066793715868 1.69069796425892e-08 -1.46869412115925 1.73406418353035e-14 mirMAP -0.246415074762893 1.09196217715879e-10 NA NA NA hsa-miR-18a-5p PCDHGA9 0.969066793715868 1.69069796425892e-08 -2.01157276235327 1.56877482228631e-26 mirMAP -0.371763758709927 4.79180816588326e-23 NA NA NA hsa-miR-18a-5p PCDHGB2 0.969066793715868 1.69069796425892e-08 -1.22861675722792 2.2343583631542e-09 mirMAP -0.189902126044122 3.49203348705015e-06 NA NA NA hsa-miR-18a-5p PCDHGB3 0.969066793715868 1.69069796425892e-08 -1.53023004510997 1.53356403301585e-15 mirMAP -0.131766555226161 0.000652098635404244 NA NA NA hsa-miR-18a-5p PCDHGB4 0.969066793715868 1.69069796425892e-08 -1.52175481038299 2.33342214942491e-11 mirMAP -0.211671953766436 3.24984970679208e-06 NA NA NA hsa-miR-18a-5p PCDHGB6 0.969066793715868 1.69069796425892e-08 -2.09691325105411 3.30306462415709e-34 mirMAP -0.314370946614473 1.55748090909347e-19 NA NA NA hsa-miR-18a-5p PCDHGB7 0.969066793715868 1.69069796425892e-08 -2.37321964922838 3.39654061037756e-37 mirMAP -0.418220524698778 3.98944932120566e-29 NA NA NA hsa-miR-18a-5p PCDHGC5 0.969066793715868 1.69069796425892e-08 -0.437476733466256 0.0245321300385338 mirMAP -0.110642905783501 0.00411137141632271 NA NA NA hsa-miR-18a-5p PDE4A 0.969066793715868 1.69069796425892e-08 -0.10844696857969 0.381039125696737 mirMAP -0.219492173758275 5.10863328798831e-20 NA NA NA hsa-miR-18a-5p PDE5A 0.969066793715868 1.69069796425892e-08 -1.75867073177592 2.55136534038232e-29 MirTarget -0.242971636442388 1.60889514256819e-14 NA NA NA hsa-miR-18a-5p PHC3 0.969066793715868 1.69069796425892e-08 -0.387331499988621 8.93540646831751e-08 MirTarget -0.139881081162043 2.42586368229585e-23 NA NA NA hsa-miR-18a-5p PRDM2 0.969066793715868 1.69069796425892e-08 -0.528669606569749 4.74973907937056e-17 mirMAP -0.135945572227408 1.74400245048004e-28 NA NA NA hsa-miR-18a-5p PRICKLE2 0.969066793715868 1.69069796425892e-08 -1.41551101306739 1.76700405075257e-30 MirTarget -0.387730469036141 3.85619154280423e-61 NA NA NA hsa-miR-18a-5p PRKACB 0.969066793715868 1.69069796425892e-08 -0.383846400368397 0.0117591306589187 miRNATAP -0.109828861303179 0.000270889162356874 NA NA NA hsa-miR-18a-5p PSD3 0.969066793715868 1.69069796425892e-08 0.0825927941452509 0.668950460041898 MirTarget;miRNATAP -0.328605773072599 1.77038091254639e-18 NA NA NA hsa-miR-18a-5p PTEN 0.969066793715868 1.69069796425892e-08 -0.737945156702629 1.26474514880987e-22 miRNAWalker2_validate;miRTarBase -0.135863155421297 1.28041670903141e-19 24681249;27291152 However higher levels of the miR-17~92 cluster switched from PTEN to oncogenes including Ctnnb1 β-catenin via miR-18a which resulted in inhibition of tumor growth and metastasis;miR 18a promotes cell proliferation of esophageal squamous cell carcinoma cells by increasing cylin D1 via regulating PTEN PI3K AKT mTOR signaling axis metastasis; colon cancer;esophageal cancer hsa-miR-18a-5p PTGR2 0.969066793715868 1.69069796425892e-08 0.00398547185307319 0.963590565960876 mirMAP -0.184357353835607 2.38040349373915e-28 NA NA NA hsa-miR-18a-5p RAB11FIP2 0.969066793715868 1.69069796425892e-08 -0.940510639961515 7.61132098193432e-42 miRNATAP -0.131419776760754 1.41019834295424e-20 NA NA NA hsa-miR-18a-5p RASSF3 0.969066793715868 1.69069796425892e-08 -1.16223946289512 2.49461115751769e-15 miRNAWalker2_validate -0.119286529464504 5.34516181306598e-05 NA NA NA hsa-miR-18a-5p REPS2 0.969066793715868 1.69069796425892e-08 0.584041800829359 0.000508205912026892 miRNATAP -0.336091234448453 3.36601961780141e-25 NA NA NA hsa-miR-18a-5p RIC3 0.969066793715868 1.69069796425892e-08 -2.77409874549096 7.75015062849707e-27 MirTarget -0.173325578344466 0.00105174522994952 NA NA NA hsa-miR-18a-5p RICTOR 0.969066793715868 1.69069796425892e-08 -0.572696811642445 2.30364963045589e-12 miRNAWalker2_validate -0.115801044552433 7.86023931866078e-13 NA NA NA hsa-miR-18a-5p RIMS4 0.969066793715868 1.69069796425892e-08 1.93936813754878 1.60005847788467e-09 mirMAP -0.416951868244038 5.72613913864664e-11 NA NA NA hsa-miR-18a-5p RNF157 0.969066793715868 1.69069796425892e-08 -2.00541806985687 4.60846624301632e-31 miRNAWalker2_validate -0.243397382730955 4.64692012386867e-12 NA NA NA hsa-miR-18a-5p ROBO2 0.969066793715868 1.69069796425892e-08 0.214473153884525 0.533803192709265 miRNATAP -0.507935667314834 4.30543821372391e-14 NA NA NA hsa-miR-18a-5p RORA 0.969066793715868 1.69069796425892e-08 -1.02145593857356 1.72079387585623e-26 MirTarget;miRNATAP -0.159888453401577 1.01092266626298e-16 NA NA NA hsa-miR-18a-5p RPS6KA5 0.969066793715868 1.69069796425892e-08 -0.957245810152851 9.30300768011881e-15 MirTarget -0.304839062313663 1.17673769849974e-37 NA NA NA hsa-miR-18a-5p RUNX1 0.969066793715868 1.69069796425892e-08 0.351934600157289 7.76643391198969e-05 miRNATAP -0.159910187601787 2.2967282372377e-20 NA NA NA hsa-miR-18a-5p SDC4 0.969066793715868 1.69069796425892e-08 0.338332926801772 0.000350382576050452 MirTarget -0.13009744301677 2.38243911448905e-12 NA NA NA hsa-miR-18a-5p SERTAD3 0.969066793715868 1.69069796425892e-08 0.389595993741587 5.03742570743981e-07 miRNAWalker2_validate -0.105493496016499 4.6995939584212e-12 NA NA NA hsa-miR-18a-5p SH3BP4 0.969066793715868 1.69069796425892e-08 0.205155411809804 0.0476799386001944 miRNATAP -0.257507232453363 1.27695549003647e-39 NA NA NA hsa-miR-18a-5p SH3RF1 0.969066793715868 1.69069796425892e-08 0.28146797029401 0.00207579433511258 miRNATAP -0.151588008583245 1.53940609351226e-17 NA NA NA hsa-miR-18a-5p SLC27A1 0.969066793715868 1.69069796425892e-08 -0.704024079872721 3.06750408458393e-16 mirMAP -0.170803449949827 5.12930789705189e-24 NA NA NA hsa-miR-18a-5p SLC35E2B 0.969066793715868 1.69069796425892e-08 -0.112960562330636 0.135373618656282 mirMAP -0.126416933557067 6.84911566025307e-18 NA NA NA hsa-miR-18a-5p SMAD3 0.969066793715868 1.69069796425892e-08 -0.590930154862025 2.18041656438712e-13 miRNAWalker2_validate -0.145191271950291 4.28063578565896e-20 23249750 The unexpected effects of miR-18a on CTGF transcription are mediated in part by direct targeting of Smad3 and ensuing weakening of TGFβ signaling glioblastoma hsa-miR-18a-5p SNED1 0.969066793715868 1.69069796425892e-08 -0.896350462657402 2.77604345772578e-14 mirMAP -0.319040754684096 5.13107237957617e-46 NA NA NA hsa-miR-18a-5p SNURF 0.969066793715868 1.69069796425892e-08 -0.252827386272411 0.262774886061011 MirTarget -0.35021993981869 1.67687544409287e-15 NA NA NA hsa-miR-18a-5p SNX33 0.969066793715868 1.69069796425892e-08 -0.583687850333784 3.86238504590758e-27 mirMAP -0.111579364347877 2.34163849455721e-25 NA NA NA hsa-miR-18a-5p SORBS2 0.969066793715868 1.69069796425892e-08 -1.55748312245062 1.12771049723563e-18 MirTarget;miRNATAP -0.120505517582452 0.000739455687797636 NA NA NA hsa-miR-18a-5p SSTR1 0.969066793715868 1.69069796425892e-08 -3.37367224819205 2.06078044997098e-50 mirMAP -0.528324795520575 1.56756939407685e-30 NA NA NA hsa-miR-18a-5p ST6GAL2 0.969066793715868 1.69069796425892e-08 1.15906949574813 1.52522181723685e-09 mirMAP -0.270495142030909 9.4894012713475e-13 NA NA NA hsa-miR-18a-5p STX1B 0.969066793715868 1.69069796425892e-08 -0.750600392365291 3.51549659031347e-07 mirMAP -0.232229169453795 9.28428200268792e-16 NA NA NA hsa-miR-18a-5p SYT15 0.969066793715868 1.69069796425892e-08 -2.18139908762213 3.24969084514856e-44 MirTarget -0.108266350583212 0.000935039095132359 NA NA NA hsa-miR-18a-5p SYT7 0.969066793715868 1.69069796425892e-08 1.01576063459312 2.15102454246002e-12 mirMAP -0.104422314630191 0.000315556188007855 NA NA NA hsa-miR-18a-5p TAOK1 0.969066793715868 1.69069796425892e-08 -1.02699433731773 5.06740042441332e-08 MirTarget;miRNATAP -0.242306979841869 7.7801284064685e-11 NA NA NA hsa-miR-18a-5p TGFBR2 0.969066793715868 1.69069796425892e-08 -2.39529308737339 4.9899056025782e-85 miRNAWalker2_validate -0.233316456798081 1.26332307500906e-18 NA NA NA hsa-miR-18a-5p TGFBR3 0.969066793715868 1.69069796425892e-08 -3.32389218515653 1.82193869897655e-62 MirTarget -0.374834046066299 3.17870910707835e-19 NA NA NA hsa-miR-18a-5p THBS1 0.969066793715868 1.69069796425892e-08 -0.0614785645873859 0.62138763262321 MirTarget -0.181152396860618 8.69562380186631e-14 NA NA NA hsa-miR-18a-5p THRA 0.969066793715868 1.69069796425892e-08 -1.02955320595519 1.31044247003034e-25 miRNAWalker2_validate -0.15778559532931 1.4522589546335e-15 NA NA NA hsa-miR-18a-5p THRB 0.969066793715868 1.69069796425892e-08 -1.90956725674414 3.33207199356048e-40 MirTarget -0.382941858083479 3.6050052574153e-41 NA NA NA hsa-miR-18a-5p TLE3 0.969066793715868 1.69069796425892e-08 0.927328348548385 1.557687497792e-29 miRNAWalker2_validate -0.175378552602682 7.02951783854717e-27 NA NA NA hsa-miR-18a-5p TNS1 0.969066793715868 1.69069796425892e-08 -2.87283202537718 5.47225880201927e-123 mirMAP -0.277210513830642 4.31505251632845e-24 NA NA NA hsa-miR-18a-5p TP73 0.969066793715868 1.69069796425892e-08 0.496595627051834 0.00711519755707105 mirMAP -0.22065384786784 1.19104385169831e-09 NA NA NA hsa-miR-18a-5p TRAF5 0.969066793715868 1.69069796425892e-08 0.721349275718834 4.75385319732411e-13 MirTarget -0.128267488900121 9.95478770535342e-11 NA NA NA hsa-miR-18a-5p TRIM8 0.969066793715868 1.69069796425892e-08 -0.15245274554067 0.0163610875921935 MirTarget -0.139326895343003 1.27470825650245e-30 NA NA NA hsa-miR-18a-5p TSC22D3 0.969066793715868 1.69069796425892e-08 -0.54824265518886 3.00229686619098e-07 miRNAWalker2_validate -0.271271829119523 9.73837470551859e-41 NA NA NA hsa-miR-18a-5p TSHZ3 0.969066793715868 1.69069796425892e-08 -0.73282959487018 6.60562399903423e-11 MirTarget;miRNATAP -0.215971774081914 6.12464974769798e-23 NA NA NA hsa-miR-18a-5p TTC28 0.969066793715868 1.69069796425892e-08 -1.65844116125173 3.58098324297455e-63 mirMAP -0.290608470141428 6.51531949277842e-48 NA NA NA hsa-miR-18a-5p TTC8 0.969066793715868 1.69069796425892e-08 0.178398576559903 0.035079271986482 MirTarget -0.24444297545988 5.60419117331458e-55 NA NA NA hsa-miR-18a-5p TXNDC15 0.969066793715868 1.69069796425892e-08 -0.12678933462949 0.0100887464640449 miRNAWalker2_validate -0.108922503750806 3.52469179828444e-31 NA NA NA hsa-miR-18a-5p UHMK1 0.969066793715868 1.69069796425892e-08 -0.304671278307886 0.114156168998821 miRNATAP -0.254562737421541 1.60229076446917e-11 NA NA NA hsa-miR-18a-5p VPS13D 0.969066793715868 1.69069796425892e-08 -0.804733095475749 3.50669376394381e-28 MirTarget -0.163352521407886 1.25880658562137e-29 NA NA NA hsa-miR-18a-5p XYLT1 0.969066793715868 1.69069796425892e-08 -0.871966257661826 2.6739267034943e-11 MirTarget -0.113201024754998 1.49525425618871e-05 NA NA NA hsa-miR-18a-5p ZBTB4 0.969066793715868 1.69069796425892e-08 -0.898210741493696 2.5617186204132e-41 MirTarget;miRNATAP -0.218847139499072 1.58588190258769e-65 NA NA NA hsa-miR-18a-5p ZBTB47 0.969066793715868 1.69069796425892e-08 -0.773093000610286 2.43222968030568e-25 MirTarget -0.10967547693471 2.2467163994578e-13 NA NA NA hsa-miR-18a-5p ZCCHC24 0.969066793715868 1.69069796425892e-08 -1.58022302811898 5.17246192367e-42 MirTarget -0.332163751402921 1.12163955486112e-47 NA NA NA hsa-miR-18a-5p ZDHHC15 0.969066793715868 1.69069796425892e-08 -1.79355508284452 1.31588141500882e-28 MirTarget -0.175569943139667 9.99000475354889e-08 NA NA NA hsa-miR-18a-5p ZHX3 0.969066793715868 1.69069796425892e-08 -1.02353107616406 7.94422939009349e-43 mirMAP -0.135125456428399 8.09976396484113e-19 NA NA NA hsa-miR-18a-5p ZMYND8 0.969066793715868 1.69069796425892e-08 0.465559261983897 2.5884513985959e-08 miRNAWalker2_validate -0.103030104846277 4.59170526405068e-10 NA NA NA hsa-miR-18a-5p ZNF365 0.969066793715868 1.69069796425892e-08 0.544881298195121 0.000430082423527048 MirTarget -0.232858888731592 1.45970435051874e-14 NA NA NA hsa-miR-18a-5p ZNF445 0.969066793715868 1.69069796425892e-08 -0.25414092017735 2.61703530644992e-05 mirMAP -0.109228839358004 1.16702328434072e-20 NA NA NA hsa-miR-18a-5p ZNF703 0.969066793715868 1.69069796425892e-08 1.38131242134889 3.98742016462884e-13 miRNAWalker2_validate -0.407959604276437 3.01410946735778e-28 NA NA NA hsa-miR-18a-5p ZNF704 0.969066793715868 1.69069796425892e-08 -1.29804603210391 1.17161901097451e-16 miRNATAP -0.25806685162268 9.87356201874314e-17 NA NA NA hsa-miR-18a-5p ZNF770 0.969066793715868 1.69069796425892e-08 -0.449063557172313 6.78853820948637e-08 miRNAWalker2_validate -0.110595044268989 1.58179475254364e-11 NA NA NA hsa-miR-18a-5p ZSWIM6 0.969066793715868 1.69069796425892e-08 -0.112225093273613 0.194358643248745 miRNAWalker2_validate -0.104021047013898 8.50443666866863e-10 NA NA NA