miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-204-5p ADAM12 -1.01965803752657 0.00767207541525746 2.40624900645293 4.34494698353113e-09 mirMAP -0.125882241617904 0.0129153875700047 NA NA NA hsa-miR-204-5p B4GALT1 -1.01965803752657 0.00767207541525746 0.358446465774574 0.0238392261794479 miRNATAP -0.10615056091811 2.29069678136552e-08 NA NA NA hsa-miR-204-5p BEND6 -1.01965803752657 0.00767207541525746 1.01988665343722 0.00304380037321792 mirMAP -0.109298636184185 0.00912824330921273 NA NA NA hsa-miR-181a-5p CALB1 -0.375429731222937 0.0562142867129802 0.611303274851926 0.314076023496669 MirTarget -0.390455756163817 0.00629039301344373 NA NA NA hsa-miR-181b-5p CALB1 0.668793269169928 0.000239998092406404 0.611303274851926 0.314076023496669 MirTarget -0.398243486413246 0.00961055043507105 NA NA NA hsa-miR-34c-3p CALB1 -1.35308017238309 0.0061932035503795 0.611303274851926 0.314076023496669 MirTarget;PITA;miRNATAP -0.152426234664503 0.00683983286285271 NA NA NA hsa-miR-34c-5p CALB1 -1.00125440032112 0.0724432896090357 0.611303274851926 0.314076023496669 PITA;miRanda -0.167675859221204 0.00145010815395173 NA NA NA hsa-miR-204-5p CELSR3 -1.01965803752657 0.00767207541525746 3.19283569563646 5.0870444214188e-19 MirTarget;miRNATAP -0.127042510365753 0.00501243332363616 NA NA NA hsa-miR-204-5p CENPL -1.01965803752657 0.00767207541525746 1.20674139615972 1.56383134724853e-12 MirTarget -0.137867513266122 3.41292557131514e-11 NA NA NA hsa-miR-204-5p CHML -1.01965803752657 0.00767207541525746 1.05743633720711 3.86544237219265e-05 mirMAP -0.102852447140242 0.00103625400314075 NA NA NA hsa-miR-204-5p CNNM4 -1.01965803752657 0.00767207541525746 0.161141488068677 0.314848586773146 miRNATAP -0.118732343124601 4.89356505509071e-10 NA NA NA hsa-miR-204-5p CPD -1.01965803752657 0.00767207541525746 0.911876479581357 9.08443596366211e-05 miRNATAP -0.134137501493315 2.00184695798262e-06 NA NA NA hsa-miR-204-5p CPNE8 -1.01965803752657 0.00767207541525746 0.0348858750889738 0.858068477972759 MirTarget;miRNATAP -0.137597340270182 3.36153694709345e-09 NA NA NA hsa-miR-204-5p ELOVL6 -1.01965803752657 0.00767207541525746 0.819759240003576 0.0278715609826653 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.126406234856553 0.00525312747063377 NA NA NA hsa-miR-204-5p ENO1 -1.01965803752657 0.00767207541525746 1.01925642521454 2.15961585416011e-11 miRNAWalker2_validate -0.105876751595094 1.26250938690432e-08 NA NA NA hsa-miR-204-5p EPHB2 -1.01965803752657 0.00767207541525746 1.7975406266136 1.80467466052593e-08 MirTarget -0.11813616525647 0.00265754605434425 NA NA NA hsa-miR-486-5p EPHB2 -4.38592782786845 2.75864166493846e-29 1.7975406266136 1.80467466052593e-08 miRanda -0.119549814942058 0.000828792350893616 NA NA NA hsa-miR-92a-3p EPHB2 -0.136362762339122 0.493412263619364 1.7975406266136 1.80467466052593e-08 miRNAWalker2_validate -0.204688149379599 0.00671158918739824 NA NA NA hsa-miR-204-5p ESCO2 -1.01965803752657 0.00767207541525746 2.41588021961706 2.07411958582756e-16 MirTarget -0.166677477759543 5.43346888854726e-06 NA NA NA hsa-miR-204-5p FAM114A1 -1.01965803752657 0.00767207541525746 0.578708166635363 0.000844960931867525 MirTarget -0.102220833362834 1.02757719834579e-06 NA NA NA hsa-miR-204-5p FBXO32 -1.01965803752657 0.00767207541525746 1.91595142423657 1.46314381556444e-12 mirMAP -0.153821645225904 4.20034379757499e-06 NA NA NA hsa-miR-204-5p FERMT1 -1.01965803752657 0.00767207541525746 2.71324340036989 8.23098407027571e-17 MirTarget -0.108148208465255 0.00828802030850732 NA NA NA hsa-miR-204-5p HMGA2 -1.01965803752657 0.00767207541525746 3.1216147936231 0.000109204646496434 miRNATAP -0.276708240491669 0.00500202736982316 27095441;26406941 We identified high mobility group protein A2 HMGA2 as a novel direct target of miR-204 and showed that miR-204 expression was decreased while HMGA2 expression was increased in CRC cell lines; Additionally both MiR-204 overexpression and HMGA2 inhibition attenuated cell proliferation whereas forced expression of HMGA2 partly restored the inhibitory effect of miR-204 on HCT116 and SW480 cells; Taken together our present study elucidated that miR-204 upregulated 5-Fu chemosensitivity via the downregulation of HMGA2 in colorectal cancer and provided significant insight into the mechanism of 5-Fu resistance in colorectal cancer patients;MiR 204 regulates HMGA2 expression and inhibits cell proliferation in human thyroid cancer; Analysis using publicly available algorithms has found that high mobility group AT-hook 2 HMGA2 a key transcriptional regulatory factor is a potential target of microRNA-204 miR-204; Some studies have shown that both miR-204 and HMGA2 are associated with cancer development; We examined the possible relationship between miR-204 and HMGA2 in the development of thyroid cancer; MiR-204 was downregulated in the thyroid cancer specimens and cell lines and targeted the 3^\prime untranslated region of HMGA2 directly drug resistance; colorectal cancer;thyroid cancer hsa-miR-204-5p HOXA10 -1.01965803752657 0.00767207541525746 2.29877460075419 0.000361263334640454 miRNAWalker2_validate;miRTarBase -0.237331736352138 0.00253138059301682 18308931 Indeed we confirmed that miR-204 targets HOXA10 and MEIS1 suggesting that the HOX up-regulation observed in NPMc+ AML may be due in part by loss of HOX regulators-miRNAs acute myeloid leukemia hsa-miR-204-5p IER5L -1.01965803752657 0.00767207541525746 1.65535900508919 2.08621839001688e-09 miRNATAP -0.115220964271684 0.000714002280742688 NA NA NA hsa-miR-204-5p IL11 -1.01965803752657 0.00767207541525746 1.88628648819733 3.75415961544606e-06 miRNAWalker2_validate;miRTarBase;MirTarget -0.132609006506597 0.00801904774579794 NA NA NA hsa-miR-204-5p IL1RAP -1.01965803752657 0.00767207541525746 0.000245152751386257 0.999187506373076 miRNAWalker2_validate -0.108955560529284 0.000176986072537337 NA NA NA hsa-miR-204-5p ITGB3 -1.01965803752657 0.00767207541525746 0.0458202617452499 0.901111456910611 miRNAWalker2_validate -0.110661310908676 0.0133517743181618 NA NA NA hsa-miR-204-5p LGR4 -1.01965803752657 0.00767207541525746 2.49487650602254 3.89808111143652e-21 MirTarget -0.166320693161242 5.69489631448296e-07 NA NA NA hsa-miR-204-5p PERP -1.01965803752657 0.00767207541525746 0.779414063228649 0.000233251614906175 MirTarget -0.133290795060303 1.84069226491974e-07 NA NA NA hsa-miR-204-5p PLAT -1.01965803752657 0.00767207541525746 0.192423484569085 0.62685971528688 miRNAWalker2_validate -0.127454324192212 0.00791319540047668 NA NA NA hsa-miR-204-5p PLAUR -1.01965803752657 0.00767207541525746 0.0779914521270308 0.757112973276917 miRNAWalker2_validate -0.140182209256048 3.78147877699475e-06 NA NA NA hsa-miR-204-5p SASS6 -1.01965803752657 0.00767207541525746 1.20237525079091 3.96958607093702e-11 MirTarget -0.11959453199886 8.0890572667844e-08 NA NA NA hsa-miR-204-5p SATB2 -1.01965803752657 0.00767207541525746 0.857948727771685 0.0016888471775028 miRNATAP -0.151556074808193 4.48252358425522e-06 NA NA NA hsa-let-7a-5p SCN8A -1.37014061604018 3.11451492971224e-14 2.36682019054299 4.79462536089325e-08 MirTarget;TargetScan -0.595521193925045 4.1076012357067e-08 NA NA NA hsa-let-7b-5p SCN8A -1.62016148171663 1.56547487335694e-15 2.36682019054299 4.79462536089325e-08 MirTarget -0.544808724099339 1.26898247679206e-08 NA NA NA hsa-let-7c-5p SCN8A -2.14139413005852 1.66416999341685e-18 2.36682019054299 4.79462536089325e-08 MirTarget -0.388859187156069 9.59496264587038e-07 NA NA NA hsa-let-7d-5p SCN8A -0.618145137285851 6.06067642715858e-05 2.36682019054299 4.79462536089325e-08 MirTarget -0.399092754116668 0.00248266625703729 NA NA NA hsa-let-7f-5p SCN8A -0.0523311272618407 0.83407808268787 2.36682019054299 4.79462536089325e-08 MirTarget -0.177135313873642 0.0297951222488102 NA NA NA hsa-miR-140-5p SCN8A 0.669142684153918 0.000335928403032308 2.36682019054299 4.79462536089325e-08 miRanda -0.358570009030668 0.00129223390177073 NA NA NA hsa-miR-144-3p SCN8A -2.1603497940894 3.64553026877274e-07 2.36682019054299 4.79462536089325e-08 MirTarget;miRNATAP -0.139870490132032 0.00494029692953384 NA NA NA hsa-miR-15b-5p SCN8A -1.25935038177398 1.83460220856901e-12 2.36682019054299 4.79462536089325e-08 MirTarget;miRNATAP -0.276871129498213 0.0130166711395475 NA NA NA hsa-miR-195-5p SCN8A -1.01577502605386 4.80814718341729e-05 2.36682019054299 4.79462536089325e-08 MirTarget;miRNATAP -0.296508789436436 0.00047595240275492 NA NA NA hsa-miR-30a-5p SCN8A -0.924084264430689 0.000762030454634728 2.36682019054299 4.79462536089325e-08 MirTarget -0.407484456271803 2.01899334471607e-08 NA NA NA hsa-miR-30c-5p SCN8A -0.327319105755825 0.123595832152687 2.36682019054299 4.79462536089325e-08 MirTarget -0.253992587227162 0.00800826107577189 NA NA NA hsa-miR-30d-5p SCN8A -0.920901858717441 3.50898334321668e-05 2.36682019054299 4.79462536089325e-08 MirTarget -0.21039312316558 0.0204680971324228 NA NA NA hsa-miR-342-5p SCN8A -0.382174669348421 0.0896996965047193 2.36682019054299 4.79462536089325e-08 miRNATAP -0.221236302089738 0.0143433314933995 NA NA NA hsa-miR-424-5p SCN8A 1.26485330287919 6.1498991028257e-06 2.36682019054299 4.79462536089325e-08 MirTarget;miRNATAP -0.164621727749837 0.0220637412964084 NA NA NA hsa-miR-486-5p SCN8A -4.38592782786845 2.75864166493846e-29 2.36682019054299 4.79462536089325e-08 MirTarget -0.205327418615622 2.16961578679944e-05 NA NA NA hsa-miR-664a-5p SCN8A -0.0936480603578111 0.662274905077117 2.36682019054299 4.79462536089325e-08 MirTarget -0.202478751759359 0.0384626408678002 NA NA NA hsa-miR-204-5p SLC5A3 -1.01965803752657 0.00767207541525746 0.908460348379878 1.7896106467656e-05 mirMAP -0.105552086542605 4.19483474867502e-05 NA NA NA hsa-miR-204-5p TFAP2A -1.01965803752657 0.00767207541525746 3.63118958402229 8.17898472391641e-17 miRNATAP -0.237887507370813 1.26211225554367e-05 NA NA NA hsa-miR-204-5p TTYH1 -1.01965803752657 0.00767207541525746 2.03453086597944 3.06858280318132e-07 miRNATAP -0.16377949427196 0.000780192383465552 NA NA NA hsa-miR-204-5p UGDH -1.01965803752657 0.00767207541525746 1.38679451794004 1.88820863787047e-06 MirTarget -0.151563807727161 1.94623231927706e-05 NA NA NA hsa-miR-204-5p WDR76 -1.01965803752657 0.00767207541525746 0.84839123621086 4.25573194795658e-05 MirTarget -0.134023753871622 8.63670211873096e-08 NA NA NA