miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7a-5p ACTB -0.210286642041636 0.0072546234707717 0.443511964210128 1.56381461645189e-12 miRNAWalker2_validate -0.206770263664064 6.75995018305145e-14 NA NA NA hsa-let-7b-5p ACTB -0.54215483448257 7.21347617597858e-08 0.443511964210128 1.56381461645189e-12 miRNAWalker2_validate -0.153447036156938 5.32772217079194e-13 NA NA NA hsa-miR-10b-5p ACTG1 -2.10996264627796 7.36811595736367e-72 0.705064523343649 4.55348682247055e-34 miRNAWalker2_validate;miRNATAP -0.152271048208906 2.45412318592821e-22 NA NA NA hsa-miR-145-5p ACTG1 -2.62703571936687 7.64402900188551e-88 0.705064523343649 4.55348682247055e-34 MirTarget;miRNATAP -0.120992999299289 1.16347849721028e-18 NA NA NA hsa-miR-106b-5p AFP 1.22477789913175 2.31787213143326e-32 -3.14179304134526 6.40602275374278e-18 miRNAWalker2_validate -0.928750916454404 2.09877222494609e-15 NA NA NA hsa-let-7e-5p AMOT 0.261471269338985 0.00191077095550257 -0.909511733140738 9.01707191016367e-13 MirTarget -0.16314562476317 0.00199212708404097 NA NA NA hsa-miR-103a-3p AMOT 0.610673390034345 1.63113920514646e-12 -0.909511733140738 9.01707191016367e-13 MirTarget -0.420005124103627 3.73599973462275e-17 NA NA NA hsa-miR-107 AMOT 0.678998026350662 2.56224148930538e-16 -0.909511733140738 9.01707191016367e-13 MirTarget;PITA;miRanda;miRNATAP -0.331809712765828 2.19084770862988e-10 NA NA NA hsa-miR-21-3p AMOT 2.17476065946878 5.15299442583591e-75 -0.909511733140738 9.01707191016367e-13 mirMAP -0.107349017141088 0.0015715981594809 NA NA NA hsa-miR-29c-3p AMOT -0.0652732378039769 0.563774115756922 -0.909511733140738 9.01707191016367e-13 MirTarget;miRNATAP -0.123993155830018 0.00158196388726718 NA NA NA hsa-miR-338-3p AMOT 0.0799903526884966 0.575137668326679 -0.909511733140738 9.01707191016367e-13 PITA -0.132186089694157 1.9579671539281e-05 NA NA NA hsa-miR-340-5p AMOT 1.0857159627596 4.94471062546756e-24 -0.909511733140738 9.01707191016367e-13 miRNAWalker2_validate;mirMAP -0.188555711423092 2.45391214146807e-06 NA NA NA hsa-miR-342-3p AMOT 1.21944481975657 6.81914373001202e-19 -0.909511733140738 9.01707191016367e-13 miRanda -0.130416668766811 3.37807203743807e-05 NA NA NA hsa-miR-98-5p AMOT 0.656336869298973 9.03113188590466e-15 -0.909511733140738 9.01707191016367e-13 MirTarget -0.169413298624582 0.00105162129973301 NA NA NA hsa-miR-106b-5p APC 1.22477789913175 2.31787213143326e-32 -0.686703117134189 5.76715056853234e-16 miRNAWalker2_validate;miRTarBase -0.313795610281918 3.20314695735614e-32 23087084 miR 106b downregulates adenomatous polyposis coli and promotes cell proliferation in human hepatocellular carcinoma; Moreover we demonstrated that miR-106b downregulates APC expression by directly targeting the 3'-untranslated region of APC messenger RNA; Taken together our results suggest that miR-106b plays an important role in promoting the proliferation of human hepatoma cells and presents a novel mechanism of micro RNA-mediated direct suppression of APC expression in cancer cells liver cancer hsa-miR-107 APC 0.678998026350662 2.56224148930538e-16 -0.686703117134189 5.76715056853234e-16 miRanda -0.266050961631061 1.99405735689927e-14 NA NA NA hsa-miR-155-5p APC 1.09766314984151 4.55650930885814e-15 -0.686703117134189 5.76715056853234e-16 miRNAWalker2_validate;miRTarBase;miRNATAP -0.154771290746743 4.27853241366662e-14 23796566 Upregulated miR 155 in papillary thyroid carcinoma promotes tumor growth by targeting APC and activating Wnt/β catenin signaling; We have searched for miR-155 targets and identified the hypothesis that miR-155 could promote tumor growth of PTC by targeted regulation of adenomatous polyposis coli APC expression and activating the Wnt/β-catenin signaling; Further studies revealed that APC is a novel miR-155 target because miR-155 bound directly to its 3'-untranslated region and reduced both the mRNA and protein levels of APC; Similar to the miR-155 over-expression APC downregulation promoted cell growth whereas rescued APC expression reversed the promotive effect of miR-155; By targeting APC miR-155 efficiently regulates the Wnt/β-catenin signaling thyroid cancer hsa-miR-21-5p APC 2.32007501846389 3.08394781855554e-137 -0.686703117134189 5.76715056853234e-16 miRNAWalker2_validate -0.246283784759972 7.23712061544539e-21 23773491;24832083 The prognostic significance of APC gene mutation and miR 21 expression in advanced stage colorectal cancer; The aim of this study was to analyse the association of APC gene mutation and miR-21 expression with clinical outcome in CRC patients; APC gene mutation and expression of APC and miR-21 were analysed by direct DNA sequencing and real-time reverse transcription polymerase chain reaction; APC gene expression was low in CRC and negatively correlated with miR-21 expression and gene mutation; In Taiwan downregulation of the APC gene in CRC correlated with gene mutation and miR-21 upregulation; APC mutation and miR-21 expression could be used to predict the clinical outcome of CRC especially in patients with advanced disease;MicroRNA 21 promotes tumour malignancy via increased nuclear translocation of β catenin and predicts poor outcome in APC mutated but not in APC wild type colorectal cancer; However in our preliminary data the prognostic value of miR-21 levels was observed only in adenomatous polyposis coli APC-mutated tumours not in APC-wild-type tumours; We enrolled 165 colorectal tumour to determine APC mutation miR-21 levels and nuclear β-catenin expression by direct sequencing real-time PCR and immunohistochemistry staging; colorectal cancer;colorectal cancer hsa-miR-27a-3p APC 0.388496361379095 1.42373532086331e-05 -0.686703117134189 5.76715056853234e-16 miRNAWalker2_validate;miRTarBase;miRNATAP -0.178295160206353 5.95535983433013e-08 22018270 Finally the APC gene was identified as the direct and functional target of miR-27 gastric cancer hsa-miR-374a-5p APC -0.239709888246804 0.00309819667153627 -0.686703117134189 5.76715056853234e-16 mirMAP -0.183579142691311 5.11997182923449e-07 NA NA NA hsa-miR-590-3p APC 1.27438512890514 1.03164723481469e-23 -0.686703117134189 5.76715056853234e-16 PITA;miRanda;mirMAP;miRNATAP -0.118033171177274 5.72074719287459e-07 NA NA NA hsa-miR-125a-5p APC2 -0.635694700253268 3.6703235721638e-11 0.94072973482498 4.47395383461655e-10 mirMAP -0.15416857175893 0.00430379284665603 NA NA NA hsa-miR-125b-5p APC2 -1.94393269763542 2.78180543229264e-58 0.94072973482498 4.47395383461655e-10 mirMAP -0.2419595151452 1.3692162649798e-09 NA NA NA hsa-miR-20a-3p APC2 -0.218902047543766 0.179868363625547 0.94072973482498 4.47395383461655e-10 mirMAP -0.138852827654145 1.45583029063542e-05 NA NA NA hsa-miR-2355-5p APC2 -0.221733044425126 0.0231054202524677 0.94072973482498 4.47395383461655e-10 mirMAP -0.186684220875449 0.000506491734344051 NA NA NA hsa-miR-28-5p APC2 -0.14267073663385 0.0497619246260571 0.94072973482498 4.47395383461655e-10 mirMAP -0.274501081998138 0.000152045555835454 NA NA NA hsa-miR-345-5p APC2 0.639728356429512 0.00013070715719672 0.94072973482498 4.47395383461655e-10 mirMAP -0.110916549318979 0.000360181957971393 NA NA NA hsa-miR-505-5p APC2 -0.842640534241897 4.43022473091907e-09 0.94072973482498 4.47395383461655e-10 mirMAP -0.173610865295371 1.44750832015884e-06 NA NA NA hsa-miR-107 AREG 0.678998026350662 2.56224148930538e-16 -0.778303606133199 0.00739078553830674 miRanda -0.406038762215162 0.000634360053700675 NA NA NA hsa-miR-330-5p AREG 0.626063225953928 3.42215028606779e-09 -0.778303606133199 0.00739078553830674 miRanda -0.335793060377933 0.000327824351427213 NA NA NA hsa-miR-590-3p AREG 1.27438512890514 1.03164723481469e-23 -0.778303606133199 0.00739078553830674 miRanda -0.406562840780303 3.20287409706028e-07 NA NA NA hsa-miR-126-5p AXIN1 -1.27745588751177 2.96000918537631e-30 1.01334328266797 2.98400439093595e-40 miRNATAP -0.232873177453548 6.89302611938727e-24 NA NA NA hsa-miR-335-5p AXIN1 -2.61355235628987 2.6462884165886e-51 1.01334328266797 2.98400439093595e-40 miRNAWalker2_validate -0.142684376401892 7.8023220735108e-23 NA NA NA hsa-miR-539-5p AXIN1 -1.28530285996605 1.62620330363951e-14 1.01334328266797 2.98400439093595e-40 miRNATAP -0.162890931040002 4.17509848174996e-25 NA NA NA hsa-let-7a-3p AXIN2 0.466622567891891 3.70886257943079e-07 -0.895665130901764 2.13015726395378e-12 miRNATAP -0.155309998742421 0.00126021107839157 NA NA NA hsa-let-7g-3p AXIN2 0.5854327663695 0.000371711766083627 -0.895665130901764 2.13015726395378e-12 MirTarget -0.15927262941163 2.22164738358529e-09 NA NA NA hsa-miR-103a-3p AXIN2 0.610673390034345 1.63113920514646e-12 -0.895665130901764 2.13015726395378e-12 miRNAWalker2_validate;MirTarget;miRNATAP -0.200585660302729 7.71528936514313e-05 NA NA NA hsa-miR-107 AXIN2 0.678998026350662 2.56224148930538e-16 -0.895665130901764 2.13015726395378e-12 miRTarBase;MirTarget;PITA;miRanda;miRNATAP -0.313818454372385 2.10386522757559e-09 26191213 miR 107 promotes hepatocellular carcinoma cell proliferation by targeting Axin2; At the molecular level our results suggested that expression of Axin2 was negatively regulated by miR-107; Our observations suggested that miR-107 could promote HCC cells proliferation via targeting Axin2 and might represent a potential therapeutic target for HCC liver cancer hsa-miR-15a-5p AXIN2 0.812445324157528 4.50263417099822e-20 -0.895665130901764 2.13015726395378e-12 MirTarget;miRNATAP -0.308482083886854 2.3359131858061e-10 26252081 The combination of miR-15a and AXIN2 significantly improved the diagnostic accuracy thyroid cancer hsa-miR-15b-5p AXIN2 0.788659356634696 1.13678211092534e-11 -0.895665130901764 2.13015726395378e-12 miRTarBase;MirTarget;miRNATAP -0.249089153159517 2.51640038854339e-11 NA NA NA hsa-miR-16-2-3p AXIN2 0.286355254959005 0.0256946046884474 -0.895665130901764 2.13015726395378e-12 mirMAP -0.242354247916614 1.68855735572963e-12 NA NA NA hsa-miR-16-5p AXIN2 0.46835991343556 1.91125356547776e-06 -0.895665130901764 2.13015726395378e-12 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.250388265601038 2.07986806159543e-08 NA NA NA hsa-miR-221-3p AXIN2 -0.317970198201501 0.00910855267413448 -0.895665130901764 2.13015726395378e-12 miRNATAP -0.187234880985831 2.24061800824779e-07 NA NA NA hsa-miR-222-3p AXIN2 -0.429279381480379 0.00103945569781115 -0.895665130901764 2.13015726395378e-12 miRNATAP -0.187336402293767 2.41688030584989e-08 NA NA NA hsa-miR-29a-5p AXIN2 0.334183773952055 0.00445137265870197 -0.895665130901764 2.13015726395378e-12 MirTarget -0.206530050833047 3.89834897393732e-08 NA NA NA hsa-miR-429 AXIN2 2.84108892259147 3.88520896426515e-64 -0.895665130901764 2.13015726395378e-12 miRanda -0.190517672757253 2.55529446378965e-15 NA NA NA hsa-miR-582-5p AXIN2 0.201134299470983 0.149482495292227 -0.895665130901764 2.13015726395378e-12 miRNATAP -0.23410335462888 1.51202842984391e-13 NA NA NA hsa-miR-590-3p AXIN2 1.27438512890514 1.03164723481469e-23 -0.895665130901764 2.13015726395378e-12 MirTarget;PITA;miRanda;miRNATAP -0.363534362507334 4.95187752463635e-26 NA NA NA hsa-let-7a-2-3p BBC3 -1.30646060964956 1.05363588067753e-14 1.65385724902316 1.48973116107111e-30 MirTarget -0.327549602963543 1.24995827027139e-29 NA NA NA hsa-let-7g-3p BBC3 0.5854327663695 0.000371711766083627 1.65385724902316 1.48973116107111e-30 MirTarget;miRNATAP -0.254397379759528 7.37724438920585e-17 NA NA NA hsa-miR-125a-5p BBC3 -0.635694700253268 3.6703235721638e-11 1.65385724902316 1.48973116107111e-30 miRNATAP -0.347024152717018 3.49069577985272e-11 NA NA NA hsa-miR-125b-5p BBC3 -1.94393269763542 2.78180543229264e-58 1.65385724902316 1.48973116107111e-30 miRNAWalker2_validate;miRTarBase -0.362160606295851 5.96237927857909e-21 25184537 Thus far two of these target genes BBC3 and NEU1 that are tumor suppressor genes but not yet studied in PDAC appear to be functional targets of miR-125b since knockdown of miR125b caused their up regulation pancreatic cancer hsa-miR-139-5p BBC3 -3.25846663863766 2.62018989415003e-112 1.65385724902316 1.48973116107111e-30 miRNATAP -0.224614533926346 1.3398029460868e-13 NA NA NA hsa-miR-140-5p BBC3 -0.755971041589807 9.68060922934542e-14 1.65385724902316 1.48973116107111e-30 miRNATAP -0.473628085409644 2.04784854852423e-22 NA NA NA hsa-miR-143-3p BBC3 -1.23248181631499 4.74160976678504e-28 1.65385724902316 1.48973116107111e-30 miRNATAP -0.217374027351567 7.85719613622932e-07 NA NA NA hsa-miR-150-5p BBC3 -0.832049526091211 3.45299201139224e-05 1.65385724902316 1.48973116107111e-30 miRNATAP -0.129873375742996 2.64339316057827e-07 NA NA NA hsa-miR-222-3p BBC3 -0.429279381480379 0.00103945569781115 1.65385724902316 1.48973116107111e-30 miRNAWalker2_validate;miRNATAP -0.296482501565522 1.39480853031015e-14 20813046 MiR 221 and miR 222 target PUMA to induce cell survival in glioblastoma poor survival glioblastoma hsa-miR-24-3p BBC3 -0.120123317289941 0.21432376743243 1.65385724902316 1.48973116107111e-30 miRNATAP -0.391129070844288 9.30844315993004e-14 NA NA NA hsa-miR-29a-5p BBC3 0.334183773952055 0.00445137265870197 1.65385724902316 1.48973116107111e-30 MirTarget;miRNATAP -0.165777172917072 0.000147170000473594 NA NA NA hsa-miR-324-3p BBC3 0.404877731996915 0.000340036423920834 1.65385724902316 1.48973116107111e-30 PITA -0.363538564773094 3.36815787329759e-16 NA NA NA hsa-miR-345-5p BBC3 0.639728356429512 0.00013070715719672 1.65385724902316 1.48973116107111e-30 miRNATAP -0.228990908761044 2.67029525819491e-14 NA NA NA hsa-miR-532-3p BBC3 -0.395473145042459 0.00686714288452761 1.65385724902316 1.48973116107111e-30 PITA;miRNATAP -0.350419893952163 6.65206801184912e-25 NA NA NA hsa-miR-29c-3p BIRC2 -0.0652732378039769 0.563774115756922 -0.297575740558402 4.48184300523481e-07 MirTarget -0.121096414722903 1.04617957302389e-11 NA NA NA hsa-let-7b-5p BIRC5 -0.54215483448257 7.21347617597858e-08 4.09209095153705 1.93163288942756e-86 miRNAWalker2_validate -0.717657500709411 9.51083018067694e-21 NA NA NA hsa-miR-101-3p BIRC5 -0.126035286271986 0.145997832808138 4.09209095153705 1.93163288942756e-86 miRNAWalker2_validate -0.557892465257233 1.06473923936842e-09 NA NA NA hsa-miR-10a-5p BIRC5 -0.798524155913801 2.99126531473748e-08 4.09209095153705 1.93163288942756e-86 miRNAWalker2_validate -0.568137262456847 8.90474435341907e-27 NA NA NA hsa-miR-218-5p BIRC5 -1.02621788318234 2.9221925445771e-23 4.09209095153705 1.93163288942756e-86 miRTarBase;MirTarget -0.682766491958607 1.29402693869976e-20 25900794;25473903;26442524 miR-218 binds survivin BIRC5 mRNA 3'-UTR and down-regulated reporter luciferase activity;Survivin BIRC5 was subsequently identified as an important cervical cancer target of miR-218 using in silico prediction mRNA profiling and quantitative real-time PCR qRT-PCR;MiR-218 promoted apoptosis inhibited cell proliferation and caused cell cycle arrest in CRC cells by suppressing BIRC5 expression; In conclusion we demonstrated that high miR-218 expression had a positive prognostic value in 5-FU-based treatments for CRC patients and discovered a novel mechanism mediated by miR-218 to promote apoptosis and to function synergistically with 5-FU to promote chemosensitivity by suppressing BIRC5 and TS in CRC ;; breast cancer;cervical and endocervical cancer;colorectal cancer hsa-miR-30c-5p BIRC5 -0.393222674580066 8.06961465717306e-05 4.09209095153705 1.93163288942756e-86 miRNAWalker2_validate -0.233925723826617 0.00332291817134807 NA NA NA hsa-miR-335-5p BIRC5 -2.61355235628987 2.6462884165886e-51 4.09209095153705 1.93163288942756e-86 miRNAWalker2_validate;MirTarget -0.48525735260279 1.19254878794e-31 23232114 Genetic variation in a miR 335 binding site in BIRC5 alters susceptibility to lung cancer in Chinese Han populations; In support of the postulation that the 3' UTR SNP may directly affect miRNA-binding site reporter gene assays indicated BIRC5 was a direct target of miR-335 and the rs2239680 T>C change resulted in altered regulation of BIRC5 expression; Our findings defined a 3' UTR SNP in human BIRC5 oncogene that may increase individual susceptibility to lung cancer probably by attenuating the interaction between miR-335 and BIRC5 lung cancer hsa-miR-34c-5p BIRC5 -0.0896438810345765 0.557016551646841 4.09209095153705 1.93163288942756e-86 miRanda -0.309009903750367 2.5807598464495e-09 NA NA NA hsa-miR-106b-5p BMP2 1.22477789913175 2.31787213143326e-32 -2.65857867772634 6.10527487782614e-50 miRNATAP -0.26660590164265 1.12724731726372e-05 NA NA NA hsa-miR-429 BMP2 2.84108892259147 3.88520896426515e-64 -2.65857867772634 6.10527487782614e-50 miRNATAP -0.40826129557167 7.17935100433753e-32 NA NA NA hsa-miR-590-3p BMP2 1.27438512890514 1.03164723481469e-23 -2.65857867772634 6.10527487782614e-50 PITA;miRanda;mirMAP -0.178033380986492 0.000666105040333196 NA NA NA hsa-miR-125a-3p BMP4 -0.176412960953959 0.10108079286419 -1.10149092310353 5.54349856867319e-09 miRanda -0.163298863788863 0.00752732533450238 NA NA NA hsa-miR-142-3p BMP4 1.53951237846104 2.06769936282034e-17 -1.10149092310353 5.54349856867319e-09 PITA;miRanda -0.225090005062372 1.21121726101325e-10 NA NA NA hsa-miR-590-3p BMP4 1.27438512890514 1.03164723481469e-23 -1.10149092310353 5.54349856867319e-09 miRanda -0.488786644087842 1.20391215808401e-21 NA NA NA hsa-miR-340-5p BMP5 1.0857159627596 4.94471062546756e-24 -4.21260848297834 3.39987684895973e-39 mirMAP -0.301115943990931 0.00419713980656556 NA NA NA hsa-miR-590-3p BMP5 1.27438512890514 1.03164723481469e-23 -4.21260848297834 3.39987684895973e-39 mirMAP -0.431944392599325 2.99721483164888e-06 NA NA NA hsa-miR-130b-3p BMP6 1.38122163823846 1.00932179737836e-26 -2.24141618102819 3.76360256327078e-50 MirTarget -0.147583952017726 0.000371484950082228 NA NA NA hsa-miR-301a-3p BMP6 1.32170168375632 2.12280368957514e-15 -2.24141618102819 3.76360256327078e-50 MirTarget -0.202490128801353 3.84192366950574e-10 NA NA NA hsa-miR-454-3p BMP6 1.28177672191095 6.84024979484587e-21 -2.24141618102819 3.76360256327078e-50 MirTarget -0.283576224076596 3.53482708336303e-13 NA NA NA hsa-miR-590-3p BMP6 1.27438512890514 1.03164723481469e-23 -2.24141618102819 3.76360256327078e-50 mirMAP -0.141427399977376 0.00131871796494223 NA NA NA hsa-let-7b-5p BMP7 -0.54215483448257 7.21347617597858e-08 -0.568347328167421 0.0198013961935752 miRNAWalker2_validate -0.258809976662431 0.0017758548082738 NA NA NA hsa-miR-30a-5p BMP7 -0.392489994825279 0.00954894667761676 -0.568347328167421 0.0198013961935752 mirMAP;miRNATAP -0.296828011310005 6.35417158979831e-08 NA NA NA hsa-miR-30c-5p BMP7 -0.393222674580066 8.06961465717306e-05 -0.568347328167421 0.0198013961935752 mirMAP;miRNATAP -0.352978199901424 2.48460436378243e-05 NA NA NA hsa-miR-338-3p BMP7 0.0799903526884966 0.575137668326679 -0.568347328167421 0.0198013961935752 miRanda -0.235089742330144 6.0197758781171e-05 NA NA NA hsa-miR-342-3p BMP7 1.21944481975657 6.81914373001202e-19 -0.568347328167421 0.0198013961935752 miRNAWalker2_validate;miRTarBase;miRanda -0.39939088547044 1.28747468011685e-11 NA NA NA hsa-miR-140-5p BMP8A -0.755971041589807 9.68060922934542e-14 2.5531168368725 9.36184416259286e-78 miRanda -0.17092515217601 0.000682416339622627 NA NA NA hsa-miR-30a-3p BMP8A -1.08956435286856 1.10750674569595e-12 2.5531168368725 9.36184416259286e-78 MirTarget -0.248477166436933 3.93577730861837e-14 NA NA NA hsa-miR-30e-3p BMP8A -0.708952170420973 1.05866470714978e-22 2.5531168368725 9.36184416259286e-78 MirTarget -0.532592839026743 1.53477893028116e-14 NA NA NA hsa-miR-423-5p BMP8A -0.0644843381453004 0.462275547464843 2.5531168368725 9.36184416259286e-78 MirTarget -0.205933948944955 0.000518526442624442 NA NA NA hsa-miR-103a-3p BMP8B 0.610673390034345 1.63113920514646e-12 0.540302731395442 0.00139550250521326 mirMAP -0.225187088163204 0.00072552447723644 NA NA NA hsa-miR-26b-5p BMP8B -0.331527896896866 0.000551258576575092 0.540302731395442 0.00139550250521326 miRNAWalker2_validate -0.157111125503936 0.00962756270933669 NA NA NA hsa-miR-34c-5p BMP8B -0.0896438810345765 0.557016551646841 0.540302731395442 0.00139550250521326 miRanda -0.143603564254755 0.000168923059126371 NA NA NA hsa-miR-362-5p BMP8B -0.248676340901797 0.0726089851456282 0.540302731395442 0.00139550250521326 mirMAP -0.155746365237471 0.0002015321545365 NA NA NA hsa-miR-340-5p BMPR1A 1.0857159627596 4.94471062546756e-24 -0.747880920024155 4.16477435098274e-20 MirTarget -0.205607556993107 7.51804306692324e-16 NA NA NA hsa-miR-589-5p BMPR1A 0.367182541239722 1.67804815542873e-05 -0.747880920024155 4.16477435098274e-20 MirTarget -0.124623957239379 0.000198491088497215 NA NA NA hsa-miR-125b-5p BMPR1B -1.94393269763542 2.78180543229264e-58 2.3325512314431 1.87054528568578e-09 miRNAWalker2_validate;miRTarBase;MirTarget -0.523279943087425 3.82265313853702e-07 19738052;21556765 A risk variant in an miR 125b binding site in BMPR1B is associated with breast cancer pathogenesis; Furthermore luciferase reporter assays and overexpression of miR-125b-mimics combined with quantitative reverse transcription-PCR showed that BMPR1B transcript is a direct target of miR-125b and that miR-125b differentially regulates the C and T alleles of rs1434536; These results suggest that allele-specific regulation of BMPR1B by miR-125b explains the observed disease risk;Our findings show that rs1434536 in the 3'UTR of BMPR1B gene affects the binding ability of miR-125b to BMPR1B mRNA and contributes to the genetic predisposition to localized prostate cancer and patients aged>70 years ; breast cancer;prostate cancer hsa-miR-130a-3p BMPR1B -1.15024914519431 6.51290317952496e-19 2.3325512314431 1.87054528568578e-09 miRNATAP -0.468510027326227 3.72612678298247e-06 NA NA NA hsa-miR-130b-3p BMPR1B 1.38122163823846 1.00932179737836e-26 2.3325512314431 1.87054528568578e-09 miRNATAP -0.330771696537828 0.00111424679509253 NA NA NA hsa-miR-140-3p BMPR1B -1.25844395244141 5.29222651039892e-33 2.3325512314431 1.87054528568578e-09 MirTarget -0.897617718710942 1.46772814243533e-13 NA NA NA hsa-miR-142-5p BMPR1B 1.16509303143593 1.96641162209073e-13 2.3325512314431 1.87054528568578e-09 mirMAP -0.444165525578716 8.90675105128216e-08 NA NA NA hsa-miR-146b-5p BMPR1B 0.631041661167954 6.20366593452965e-08 2.3325512314431 1.87054528568578e-09 miRanda -0.763779914564347 1.66236814877754e-11 NA NA NA hsa-miR-150-5p BMPR1B -0.832049526091211 3.45299201139224e-05 2.3325512314431 1.87054528568578e-09 MirTarget -0.447906956063762 1.00992000293386e-11 NA NA NA hsa-miR-205-5p BMPR1B -1.70057043266505 1.20976599540743e-09 2.3325512314431 1.87054528568578e-09 miRNATAP -0.128948367199523 0.00663542809472005 NA NA NA hsa-miR-23a-3p BMPR1B -0.217176729033818 0.00962615056202409 2.3325512314431 1.87054528568578e-09 mirMAP -0.54134602392377 0.000777327916413561 NA NA NA hsa-miR-24-3p BMPR1B -0.120123317289941 0.21432376743243 2.3325512314431 1.87054528568578e-09 miRNATAP -0.924083329815397 2.27189205259187e-11 NA NA NA hsa-miR-26a-5p BMPR1B -0.481180084102235 1.82368246174758e-10 2.3325512314431 1.87054528568578e-09 mirMAP -0.502628260270685 0.004703613816135 NA NA NA hsa-miR-374a-5p BMPR1B -0.239709888246804 0.00309819667153627 2.3325512314431 1.87054528568578e-09 MirTarget -1.34531949769775 2.36721949756409e-16 NA NA NA hsa-miR-374b-5p BMPR1B -0.466781429946153 1.17238311619116e-08 2.3325512314431 1.87054528568578e-09 MirTarget -1.21428024206699 6.08013000870106e-14 NA NA NA hsa-miR-576-5p BMPR1B 0.0649387707567879 0.588791966096287 2.3325512314431 1.87054528568578e-09 mirMAP -0.437349947086476 9.41645537856705e-05 NA NA NA hsa-miR-590-3p BMPR1B 1.27438512890514 1.03164723481469e-23 2.3325512314431 1.87054528568578e-09 miRanda;mirMAP -0.285771807763549 0.00802490630601688 NA NA NA hsa-miR-889-3p BMPR1B -0.377352927733213 0.00501260024755438 2.3325512314431 1.87054528568578e-09 MirTarget -0.507675391479965 3.5174865160677e-07 NA NA NA hsa-miR-106b-5p BMPR2 1.22477789913175 2.31787213143326e-32 -0.619963448559116 4.34614935044474e-16 MirTarget;miRNATAP -0.276781658266959 5.38230356337068e-31 NA NA NA hsa-miR-128-3p BMPR2 0.90296715955238 9.925204823863e-23 -0.619963448559116 4.34614935044474e-16 miRNAWalker2_validate -0.220456287512942 2.32429009664863e-15 NA NA NA hsa-miR-130b-3p BMPR2 1.38122163823846 1.00932179737836e-26 -0.619963448559116 4.34614935044474e-16 MirTarget;miRNATAP -0.132800742011577 2.36935481480511e-11 NA NA NA hsa-miR-148a-5p BMPR2 0.572692271754695 2.14306251522796e-06 -0.619963448559116 4.34614935044474e-16 mirMAP -0.120124264765292 3.51868525242609e-08 NA NA NA hsa-miR-17-5p BMPR2 0.599531757298529 1.07318660415906e-05 -0.619963448559116 4.34614935044474e-16 miRNAWalker2_validate;MirTarget;TargetScan;miRNATAP -0.169916613515935 4.71819035178939e-19 NA NA NA hsa-miR-181a-5p BMPR2 0.635863607630183 6.72486918157744e-11 -0.619963448559116 4.34614935044474e-16 miRNATAP -0.224587920836486 3.17918043865356e-17 NA NA NA hsa-miR-181b-5p BMPR2 1.22749257795094 1.21998198830919e-27 -0.619963448559116 4.34614935044474e-16 miRNATAP -0.224720984868525 5.95101149780694e-24 NA NA NA hsa-miR-181c-5p BMPR2 0.574847839298605 4.51287502066478e-07 -0.619963448559116 4.34614935044474e-16 miRNAWalker2_validate;miRNATAP -0.153556997294714 2.48251772986161e-11 NA NA NA hsa-miR-185-5p BMPR2 0.482334746589337 3.68475879959415e-09 -0.619963448559116 4.34614935044474e-16 MirTarget -0.344917833393806 4.84718132418701e-28 NA NA NA hsa-miR-19a-3p BMPR2 0.817507952171848 3.76285090469625e-08 -0.619963448559116 4.34614935044474e-16 miRNAWalker2_validate;MirTarget;miRNATAP -0.155870077480006 3.19291951165458e-19 NA NA NA hsa-miR-19b-3p BMPR2 0.139124391010031 0.255658553872934 -0.619963448559116 4.34614935044474e-16 miRNAWalker2_validate;MirTarget;miRNATAP -0.135077875250079 3.91490815909773e-10 NA NA NA hsa-miR-200b-3p BMPR2 2.11744072703209 1.66710572104191e-43 -0.619963448559116 4.34614935044474e-16 mirMAP -0.121047661495268 8.73119456445721e-14 NA NA NA hsa-miR-200c-3p BMPR2 2.07038651806183 6.84613386286599e-51 -0.619963448559116 4.34614935044474e-16 mirMAP -0.13697648800764 1.55247615315968e-14 NA NA NA hsa-miR-20a-5p BMPR2 0.44979911120222 0.000602386964327228 -0.619963448559116 4.34614935044474e-16 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.249993991973903 3.35999987947366e-38 NA NA NA hsa-miR-21-5p BMPR2 2.32007501846389 3.08394781855554e-137 -0.619963448559116 4.34614935044474e-16 miRNAWalker2_validate;miRTarBase;MirTarget -0.217097837256464 4.31156278024056e-20 NA NA NA hsa-miR-25-3p BMPR2 -0.00546790775985073 0.944061771389468 -0.619963448559116 4.34614935044474e-16 miRNATAP -0.22770448332314 2.41816718314955e-11 NA NA NA hsa-miR-32-5p BMPR2 1.38676603945192 2.29428299685976e-34 -0.619963448559116 4.34614935044474e-16 miRNATAP -0.174672112420236 3.33558378279438e-15 NA NA NA hsa-miR-340-5p BMPR2 1.0857159627596 4.94471062546756e-24 -0.619963448559116 4.34614935044474e-16 mirMAP -0.227147675302332 5.38594766443045e-22 NA NA NA hsa-miR-361-5p BMPR2 -0.0996867547900457 0.095428250126326 -0.619963448559116 4.34614935044474e-16 MirTarget;miRanda;mirMAP;miRNATAP -0.334517180577302 6.53819650110874e-14 NA NA NA hsa-miR-374a-3p BMPR2 0.34122393953022 2.28714105382856e-05 -0.619963448559116 4.34614935044474e-16 MirTarget;miRNATAP -0.118088688320067 0.000357901047098203 NA NA NA hsa-miR-429 BMPR2 2.84108892259147 3.88520896426515e-64 -0.619963448559116 4.34614935044474e-16 mirMAP;miRNATAP -0.12305207734683 1.41517075947211e-17 NA NA NA hsa-miR-455-5p BMPR2 0.284641224662773 0.0357572339594277 -0.619963448559116 4.34614935044474e-16 PITA -0.150702454713517 6.6886302737598e-15 NA NA NA hsa-miR-532-5p BMPR2 0.0386976222860582 0.682018574136515 -0.619963448559116 4.34614935044474e-16 PITA -0.19453245376842 3.69016564906427e-12 NA NA NA hsa-miR-590-3p BMPR2 1.27438512890514 1.03164723481469e-23 -0.619963448559116 4.34614935044474e-16 MirTarget;miRanda;mirMAP;miRNATAP -0.132760837851511 3.2984433329505e-10 NA NA NA hsa-miR-671-5p BMPR2 1.55248047544015 7.7377784125886e-33 -0.619963448559116 4.34614935044474e-16 miRNATAP -0.189454100614002 3.2885754867585e-22 NA NA NA hsa-miR-769-5p BMPR2 0.564871766265874 8.16695101656941e-10 -0.619963448559116 4.34614935044474e-16 miRNATAP -0.105758705299915 0.000232905961375314 NA NA NA hsa-miR-92a-3p BMPR2 -0.342420481092807 0.000732275969501111 -0.619963448559116 4.34614935044474e-16 miRNAWalker2_validate;miRNATAP -0.157420472890194 1.52521487852708e-09 NA NA NA hsa-miR-93-5p BMPR2 1.01788600209314 1.24312921618126e-21 -0.619963448559116 4.34614935044474e-16 miRNAWalker2_validate;MirTarget;miRNATAP -0.297498916175773 3.22742453305909e-37 NA NA NA hsa-miR-107 BTRC 0.678998026350662 2.56224148930538e-16 0.120536048906525 0.159286798668058 MirTarget;miRanda;miRNATAP -0.176399193835294 3.95816507165993e-07 NA NA NA hsa-miR-130a-3p BTRC -1.15024914519431 6.51290317952496e-19 0.120536048906525 0.159286798668058 mirMAP -0.123950670209092 1.81836770188752e-08 NA NA NA hsa-miR-130b-3p BTRC 1.38122163823846 1.00932179737836e-26 0.120536048906525 0.159286798668058 mirMAP -0.166208529900913 2.6200359050573e-14 NA NA NA hsa-miR-132-3p BTRC -0.0365213889238607 0.668598301088667 0.120536048906525 0.159286798668058 MirTarget -0.16624989082982 1.42128564671786e-06 NA NA NA hsa-miR-15a-5p BTRC 0.812445324157528 4.50263417099822e-20 0.120536048906525 0.159286798668058 miRNAWalker2_validate;MirTarget;miRNATAP -0.190986059010062 3.25059412787152e-09 NA NA NA hsa-miR-185-5p BTRC 0.482334746589337 3.68475879959415e-09 0.120536048906525 0.159286798668058 mirMAP -0.27817268481314 2.83790268646345e-15 NA NA NA hsa-miR-186-5p BTRC -0.426987301460247 1.04129380549315e-05 0.120536048906525 0.159286798668058 mirMAP -0.153390623021547 3.48923481425663e-07 NA NA NA hsa-miR-212-3p BTRC 0.24081906669865 0.0571447155653209 0.120536048906525 0.159286798668058 MirTarget -0.173369799058415 8.47662747538148e-14 NA NA NA hsa-miR-22-5p BTRC 0.238328801322329 0.0377496760295305 0.120536048906525 0.159286798668058 miRNATAP -0.169967299467369 1.97069244765403e-11 NA NA NA hsa-miR-224-5p BTRC -2.22249420723892 1.07787949391113e-18 0.120536048906525 0.159286798668058 MirTarget -0.132498017840424 7.27857382043359e-34 NA NA NA hsa-miR-28-5p BTRC -0.14267073663385 0.0497619246260571 0.120536048906525 0.159286798668058 miRanda -0.245382923565365 1.23962341723426e-09 NA NA NA hsa-miR-361-3p BTRC -0.0370446538644886 0.624902392829872 0.120536048906525 0.159286798668058 MirTarget;PITA;miRNATAP -0.232101959717311 2.15887515093051e-09 NA NA NA hsa-miR-505-3p BTRC -0.530462599544864 7.71645736541597e-05 0.120536048906525 0.159286798668058 MirTarget -0.19714346161221 2.15462077391573e-20 NA NA NA hsa-miR-576-5p BTRC 0.0649387707567879 0.588791966096287 0.120536048906525 0.159286798668058 mirMAP -0.106901631789694 1.17834154523049e-05 NA NA NA hsa-miR-92a-3p BTRC -0.342420481092807 0.000732275969501111 0.120536048906525 0.159286798668058 miRNAWalker2_validate -0.218742875572353 1.77336318401607e-14 NA NA NA hsa-let-7i-5p CCND1 -0.333419326258177 3.56960810786801e-08 0.789100261201456 1.48424202389562e-06 miRNATAP -0.759700962013673 2.31065071397228e-16 NA NA NA hsa-miR-106a-5p CCND1 0.574594373206545 0.000145868284001732 0.789100261201456 1.48424202389562e-06 MirTarget;miRNATAP -0.174359830876255 2.65007775906387e-06 NA NA NA hsa-miR-106b-5p CCND1 1.22477789913175 2.31787213143326e-32 0.789100261201456 1.48424202389562e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.258644062815507 8.24041501542474e-07 NA NA NA hsa-miR-142-3p CCND1 1.53951237846104 2.06769936282034e-17 0.789100261201456 1.48424202389562e-06 miRanda -0.111966511365121 0.000240262100008297 23619912 Transfection of miR-142-3p mimics in colon cancer cells downregulated cyclin D1 expression induced G1 phase cell cycle arrest and elevated the sensitivity of the cells to 5-fluorouracil colon cancer hsa-miR-142-5p CCND1 1.16509303143593 1.96641162209073e-13 0.789100261201456 1.48424202389562e-06 PITA -0.210173449112337 1.63510921192815e-09 NA NA NA hsa-miR-150-5p CCND1 -0.832049526091211 3.45299201139224e-05 0.789100261201456 1.48424202389562e-06 mirMAP -0.187252742453937 1.34917625164856e-11 NA NA NA hsa-miR-155-5p CCND1 1.09766314984151 4.55650930885814e-15 0.789100261201456 1.48424202389562e-06 miRNAWalker2_validate -0.298681895389198 2.32439253453393e-14 26955820 MicroRNA 155 expression inversely correlates with pathologic stage of gastric cancer and it inhibits gastric cancer cell growth by targeting cyclin D1 staging gastric cancer hsa-miR-15b-5p CCND1 0.788659356634696 1.13678211092534e-11 0.789100261201456 1.48424202389562e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.125463191460891 0.00921827566968511 NA NA NA hsa-miR-17-5p CCND1 0.599531757298529 1.07318660415906e-05 0.789100261201456 1.48424202389562e-06 miRNAWalker2_validate;MirTarget;TargetScan;miRNATAP -0.23795787679729 6.72139201694027e-09 26431674 Bioinformatics Prediction and In Vitro Analysis Revealed That miR 17 Targets Cyclin D1 mRNA in Triple Negative Breast Cancer Cells; In this study using bioinformatic analyses miR-17 was selected as it targets the 3'UTR of CCND1 gene with the highest score; After lentiviral transduction of miR-17 to the target cells gene expression analysis showed decreased expression of CCND1 gene breast cancer hsa-miR-186-5p CCND1 -0.426987301460247 1.04129380549315e-05 0.789100261201456 1.48424202389562e-06 mirMAP -0.494988902443749 5.18517439622754e-18 NA NA NA hsa-miR-19a-3p CCND1 0.817507952171848 3.76285090469625e-08 0.789100261201456 1.48424202389562e-06 miRNAWalker2_validate;miRTarBase;miRNATAP -0.216023850578105 8.24189814452405e-09 25985117 Moreover miR-19a might play inhibitory roles in HCC malignancy via regulating Cyclin D1 expression liver cancer hsa-miR-19b-1-5p CCND1 0.647704962003062 3.07687667945597e-07 0.789100261201456 1.48424202389562e-06 miRNAWalker2_validate;miRTarBase -0.206802040114629 3.03348057195458e-06 NA NA NA hsa-miR-19b-3p CCND1 0.139124391010031 0.255658553872934 0.789100261201456 1.48424202389562e-06 miRNATAP -0.249444343540709 5.93160032007176e-08 NA NA NA hsa-miR-20a-5p CCND1 0.44979911120222 0.000602386964327228 0.789100261201456 1.48424202389562e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.218045690926451 3.58399990050218e-07 NA NA NA hsa-miR-23b-3p CCND1 -0.363202401123049 0.000265305319764878 0.789100261201456 1.48424202389562e-06 miRNATAP -0.2085521275068 0.000237936656088415 NA NA NA hsa-miR-29a-3p CCND1 -0.699539666833076 1.13935003139957e-13 0.789100261201456 1.48424202389562e-06 mirMAP -0.358623457755512 1.12263469726765e-09 NA NA NA hsa-miR-340-5p CCND1 1.0857159627596 4.94471062546756e-24 0.789100261201456 1.48424202389562e-06 mirMAP -0.157803294541288 0.00210629660665075 NA NA NA hsa-miR-374a-5p CCND1 -0.239709888246804 0.00309819667153627 0.789100261201456 1.48424202389562e-06 MirTarget -0.556352001430099 7.67413515717595e-16 27191497 microRNA 374a suppresses colon cancer progression by directly reducing CCND1 to inactivate the PI3K/AKT pathway; Furthermore luciferase reporter assays confirmed that miR-374a could directly reduce CCND1; We examined miR-374a levels by in situ hybridization and its correlation with CCND1 expression in CRC tumor tissues; High miR-374a expression with low level of CCND1 was protective factor in CRC; Together these findings indicate that miR-374a inactivates the PI3K/AKT axis by inhibiting CCND1 suppressing of colon cancer progression progression colon cancer hsa-miR-374b-5p CCND1 -0.466781429946153 1.17238311619116e-08 0.789100261201456 1.48424202389562e-06 miRNAWalker2_validate;MirTarget -0.531193112029599 5.3445494840887e-15 NA NA NA hsa-miR-424-5p CCND1 0.420789584199235 0.00480101660479489 0.789100261201456 1.48424202389562e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.165346668007668 1.17175782770906e-05 NA NA NA hsa-miR-495-3p CCND1 -1.67685437612894 1.70634429769052e-34 0.789100261201456 1.48424202389562e-06 MirTarget -0.2655760978611 1.39010362325337e-11 NA NA NA hsa-miR-511-5p CCND1 -2.27545475897362 3.84085514050558e-36 0.789100261201456 1.48424202389562e-06 MirTarget -0.21938803198833 1.27831310404617e-13 NA NA NA hsa-miR-589-3p CCND1 0.0263457630961427 0.866577983997705 0.789100261201456 1.48424202389562e-06 MirTarget -0.116809863299678 0.00155105242627909 NA NA NA hsa-miR-590-3p CCND1 1.27438512890514 1.03164723481469e-23 0.789100261201456 1.48424202389562e-06 mirMAP -0.221641713536578 8.94498108920728e-07 NA NA NA hsa-miR-9-5p CCND1 0.734772328078424 0.00261982843636383 0.789100261201456 1.48424202389562e-06 miRNAWalker2_validate -0.162121975003827 1.12937727530253e-12 NA NA NA hsa-miR-92a-3p CCND1 -0.342420481092807 0.000732275969501111 0.789100261201456 1.48424202389562e-06 miRNAWalker2_validate -0.355039027931141 1.3665845638516e-10 NA NA NA hsa-miR-93-5p CCND1 1.01788600209314 1.24312921618126e-21 0.789100261201456 1.48424202389562e-06 miRNAWalker2_validate;MirTarget;miRNATAP -0.160469090487963 0.00197437840989499 NA NA NA hsa-miR-942-5p CCND1 0.0274758353801279 0.842368857038259 0.789100261201456 1.48424202389562e-06 MirTarget -0.261175156275166 1.39422778172566e-10 NA NA NA hsa-let-7a-3p CCND2 0.466622567891891 3.70886257943079e-07 -1.32381712777542 1.10807863083966e-33 mirMAP -0.215275364862757 3.63993039775257e-07 20418948 MicroRNA let 7a inhibits proliferation of human prostate cancer cells in vitro and in vivo by targeting E2F2 and CCND2 prostate cancer hsa-let-7e-5p CCND2 0.261471269338985 0.00191077095550257 -1.32381712777542 1.10807863083966e-33 miRNATAP -0.168033346737038 0.000309648297817392 NA NA NA hsa-miR-106a-5p CCND2 0.574594373206545 0.000145868284001732 -1.32381712777542 1.10807863083966e-33 miRNATAP -0.117204496646304 5.04333413242193e-06 NA NA NA hsa-miR-106b-5p CCND2 1.22477789913175 2.31787213143326e-32 -1.32381712777542 1.10807863083966e-33 miRNAWalker2_validate;miRTarBase;miRNATAP -0.324304654054346 9.75129599972944e-20 NA NA NA hsa-miR-130b-5p CCND2 1.0573161199584 2.55177349228739e-12 -1.32381712777542 1.10807863083966e-33 mirMAP -0.113060251982174 8.9777676148938e-06 NA NA NA hsa-miR-141-3p CCND2 2.99777540204168 1.26370498493024e-78 -1.32381712777542 1.10807863083966e-33 MirTarget;TargetScan -0.300723945575078 8.35441899721039e-47 NA NA NA hsa-miR-151a-3p CCND2 0.3530403796941 3.45015092968892e-05 -1.32381712777542 1.10807863083966e-33 mirMAP -0.17767569994557 0.000108302525662849 NA NA NA hsa-miR-15a-5p CCND2 0.812445324157528 4.50263417099822e-20 -1.32381712777542 1.10807863083966e-33 miRNAWalker2_validate;miRTarBase;miRNATAP -0.382989347535057 1.85935181542133e-19 NA NA NA hsa-miR-15b-5p CCND2 0.788659356634696 1.13678211092534e-11 -1.32381712777542 1.10807863083966e-33 miRNATAP -0.200863767053961 1.18885859507843e-09 NA NA NA hsa-miR-16-5p CCND2 0.46835991343556 1.91125356547776e-06 -1.32381712777542 1.10807863083966e-33 miRNAWalker2_validate;miRNATAP -0.126011969570663 0.00149555991801246 NA NA NA hsa-miR-17-5p CCND2 0.599531757298529 1.07318660415906e-05 -1.32381712777542 1.10807863083966e-33 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.218141508896336 9.56625930755479e-15 NA NA NA hsa-miR-182-5p CCND2 2.36408084103818 2.60011457600281e-72 -1.32381712777542 1.10807863083966e-33 miRNAWalker2_validate;miRTarBase;miRNATAP -0.333755066801542 7.98233999507297e-38 NA NA NA hsa-miR-183-5p CCND2 2.95681814393872 1.09965777344285e-92 -1.32381712777542 1.10807863083966e-33 miRNATAP -0.301857921065621 1.16754966176673e-39 NA NA NA hsa-miR-185-5p CCND2 0.482334746589337 3.68475879959415e-09 -1.32381712777542 1.10807863083966e-33 MirTarget;miRNATAP -0.252091965164496 1.07493887045353e-07 NA NA NA hsa-miR-191-5p CCND2 0.831652724468215 1.98847993606895e-12 -1.32381712777542 1.10807863083966e-33 MirTarget -0.190841372088135 4.05600831845751e-09 NA NA NA hsa-miR-19a-3p CCND2 0.817507952171848 3.76285090469625e-08 -1.32381712777542 1.10807863083966e-33 MirTarget;miRNATAP -0.185131062383478 6.94387115240903e-13 NA NA NA hsa-miR-19b-3p CCND2 0.139124391010031 0.255658553872934 -1.32381712777542 1.10807863083966e-33 miRNAWalker2_validate;MirTarget;miRNATAP -0.166767747836903 1.62862778749919e-07 NA NA NA hsa-miR-200a-3p CCND2 2.55218480823434 2.96135446816238e-51 -1.32381712777542 1.10807863083966e-33 MirTarget -0.261226562912324 4.31939405604759e-36 NA NA NA hsa-miR-20a-5p CCND2 0.44979911120222 0.000602386964327228 -1.32381712777542 1.10807863083966e-33 miRNAWalker2_validate;miRTarBase;miRNATAP -0.235095611327971 1.01223581717651e-15 NA NA NA hsa-miR-20b-5p CCND2 0.78236583455125 8.7938334801223e-05 -1.32381712777542 1.10807863083966e-33 miRNATAP -0.104708964184932 6.77204420924901e-08 NA NA NA hsa-miR-21-3p CCND2 2.17476065946878 5.15299442583591e-75 -1.32381712777542 1.10807863083966e-33 mirMAP -0.127404398971718 2.08059143790106e-05 NA NA NA hsa-miR-29b-3p CCND2 0.438847962603729 6.46722433236121e-05 -1.32381712777542 1.10807863083966e-33 MirTarget;miRNATAP -0.166630108966211 2.5453033344596e-06 22330340;24130168 In addition to CCND2 miR-29 also targets E2F7 another cell cycle regulator;We further demonstrated that miR-29 family acted as tumor suppressors through targeting CCND2 and matrix metalloproteinase-2 genes in GC ; sarcoma;gastric cancer hsa-miR-301a-3p CCND2 1.32170168375632 2.12280368957514e-15 -1.32381712777542 1.10807863083966e-33 miRNAWalker2_validate -0.182363632693643 1.4299291622836e-15 NA NA NA hsa-miR-3065-3p CCND2 1.62787885002468 6.81477830005026e-19 -1.32381712777542 1.10807863083966e-33 MirTarget;miRNATAP -0.215305118861858 1.68654607913855e-26 NA NA NA hsa-miR-30d-3p CCND2 0.264544633563642 0.00755023189129747 -1.32381712777542 1.10807863083966e-33 mirMAP -0.277305057640272 1.40644960106378e-12 NA NA NA hsa-miR-320b CCND2 0.412787504747938 0.00113457276903985 -1.32381712777542 1.10807863083966e-33 mirMAP;miRNATAP -0.105338094438455 0.000662995774848357 NA NA NA hsa-miR-324-3p CCND2 0.404877731996915 0.000340036423920834 -1.32381712777542 1.10807863083966e-33 miRNAWalker2_validate -0.187482582074807 4.91214943402943e-08 NA NA NA hsa-miR-331-5p CCND2 0.682437632502949 4.10871642662371e-11 -1.32381712777542 1.10807863083966e-33 miRNATAP -0.224823939820064 1.69348201302645e-09 NA NA NA hsa-miR-342-3p CCND2 1.21944481975657 6.81914373001202e-19 -1.32381712777542 1.10807863083966e-33 miRNAWalker2_validate;mirMAP -0.103848624831325 0.000189231379572542 NA NA NA hsa-miR-429 CCND2 2.84108892259147 3.88520896426515e-64 -1.32381712777542 1.10807863083966e-33 miRNATAP -0.232180070081619 1.04111918722712e-28 NA NA NA hsa-miR-590-3p CCND2 1.27438512890514 1.03164723481469e-23 -1.32381712777542 1.10807863083966e-33 miRanda;mirMAP -0.13833737728579 9.4871454586344e-06 NA NA NA hsa-miR-590-5p CCND2 0.746515607868274 8.51300479640125e-09 -1.32381712777542 1.10807863083966e-33 mirMAP -0.151134124586935 3.93710909950627e-07 NA NA NA hsa-miR-660-5p CCND2 0.406910761707485 0.000156175371762464 -1.32381712777542 1.10807863083966e-33 mirMAP -0.106401121539045 0.00339848496849202 NA NA NA hsa-miR-7-1-3p CCND2 0.686579567507582 1.20731554448806e-07 -1.32381712777542 1.10807863083966e-33 mirMAP -0.138929082076826 3.22847149980611e-06 NA NA NA hsa-miR-93-5p CCND2 1.01788600209314 1.24312921618126e-21 -1.32381712777542 1.10807863083966e-33 miRNATAP -0.400435186075896 5.37578279205249e-31 NA NA NA hsa-miR-96-5p CCND2 3.24596558166606 1.92296159041707e-98 -1.32381712777542 1.10807863083966e-33 TargetScan;miRNATAP -0.311897703713413 7.58506265459077e-49 NA NA NA hsa-miR-139-5p CDH1 -3.25846663863766 2.62018989415003e-112 0.993129597727878 4.15803450566148e-06 PITA;miRanda -0.256252618046659 7.41938846648008e-09 NA NA NA hsa-miR-185-5p CDH1 0.482334746589337 3.68475879959415e-09 0.993129597727878 4.15803450566148e-06 MirTarget -0.271318090909206 0.00279376084089081 27212161;24025511 We also found that ectopic expression of miR-185 reversed EMT via the up-regulation of E-cadherin and down-regulation of vimentin in epithelial and mesenchymal HCC cells;After transfection of miR-185 inhibitor into KYSE30 the expression of E-cadherin a downstream protein of Six1 was observed under confocal microscope; After transfection of miR-185 inhibitorthe expression level of E-cadherin decreased ; liver cancer;esophageal cancer hsa-miR-199a-5p CDH1 -0.314703593105081 0.00909304983051124 0.993129597727878 4.15803450566148e-06 MirTarget;miRanda -0.202937063876235 0.000996047027924914 25080937 In contrast inhibition of miR-199a-5p impaired the metastatic potential of GC cells in vitro and in vivo and E-cadherin was identified as a direct and functional target of miR-199a-5p in GC cells gastric cancer hsa-miR-199b-5p CDH1 -1.37022396448377 3.25758057539223e-26 0.993129597727878 4.15803450566148e-06 MirTarget;miRanda -0.2419137591555 1.34798514113907e-05 NA NA NA hsa-miR-22-3p CDH1 -0.505819481364718 1.90494905330622e-13 0.993129597727878 4.15803450566148e-06 MirTarget -0.358688632053019 0.000867237783732934 NA NA NA hsa-miR-335-3p CDH1 -1.88448538773649 2.09538234398335e-32 0.993129597727878 4.15803450566148e-06 mirMAP -0.207241089008551 3.67067137282452e-06 NA NA NA hsa-let-7d-5p CRB2 0.410958462607207 6.07808182756787e-06 -2.19518094541831 2.07086175228115e-27 miRNATAP -0.382772486615393 1.13835917648565e-06 NA NA NA hsa-miR-193a-3p CRB2 0.310617999804917 0.00477640270974957 -2.19518094541831 2.07086175228115e-27 miRanda -0.36546950511105 1.72549075363311e-08 NA NA NA hsa-miR-197-3p CRB2 -0.526589453596294 3.61594599437195e-06 -2.19518094541831 2.07086175228115e-27 mirMAP -0.195456415422556 0.00189180020299538 NA NA NA hsa-miR-320b CRB2 0.412787504747938 0.00113457276903985 -2.19518094541831 2.07086175228115e-27 miRanda -0.225672144811861 6.90787962151695e-05 NA NA NA hsa-miR-342-3p CRB2 1.21944481975657 6.81914373001202e-19 -2.19518094541831 2.07086175228115e-27 miRNAWalker2_validate;miRanda -0.135645833680697 0.00801030633697416 NA NA NA hsa-miR-1271-5p CSNK1D -1.08290983583835 3.85149976357318e-12 0.413762709311119 8.26406352950355e-16 MirTarget -0.10118240394318 1.41800649002688e-19 NA NA NA hsa-miR-16-2-3p CTGF 0.286355254959005 0.0256946046884474 -0.492053877527233 0.000535095367324139 MirTarget -0.281591567371326 9.36643387330157e-14 NA NA NA hsa-miR-18a-5p CTGF 0.969066793715868 1.69069796425892e-08 -0.492053877527233 0.000535095367324139 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.119846814285957 2.0448230920207e-05 23249750 Targeting of TGFβ signature and its essential component CTGF by miR 18 correlates with improved survival in glioblastoma; Indeed microRNA-18a but not other miR-17∼92 members has a functional site in the CTGF 3' UTR and its forced reexpression sharply reduces CTGF protein and mRNA levels; The unexpected effects of miR-18a on CTGF transcription are mediated in part by direct targeting of Smad3 and ensuing weakening of TGFβ signaling poor survival glioblastoma hsa-miR-19a-3p CTGF 0.817507952171848 3.76285090469625e-08 -0.492053877527233 0.000535095367324139 MirTarget;miRNATAP -0.164903918611996 3.73847281655573e-07 NA NA NA hsa-miR-19b-3p CTGF 0.139124391010031 0.255658553872934 -0.492053877527233 0.000535095367324139 MirTarget;miRNATAP -0.161266734152368 5.31562756662891e-05 NA NA NA hsa-miR-330-3p CTGF 0.432728362037032 0.00041335506960812 -0.492053877527233 0.000535095367324139 MirTarget;PITA;miRNATAP -0.167622175608169 3.13598062797761e-05 NA NA NA hsa-miR-361-3p CTGF -0.0370446538644886 0.624902392829872 -0.492053877527233 0.000535095367324139 MirTarget;miRNATAP -0.185041203403867 0.0044938981231653 NA NA NA hsa-miR-375 CTGF 2.09893673049766 1.68351780396203e-16 -0.492053877527233 0.000535095367324139 miRNAWalker2_validate;miRanda -0.104861961985773 1.91267729749617e-08 NA NA NA hsa-miR-590-3p CTGF 1.27438512890514 1.03164723481469e-23 -0.492053877527233 0.000535095367324139 PITA;miRanda -0.260888567866293 1.61748443001636e-11 NA NA NA hsa-miR-7-1-3p CTGF 0.686579567507582 1.20731554448806e-07 -0.492053877527233 0.000535095367324139 MirTarget -0.267500589922773 4.43151453305981e-13 NA NA NA hsa-miR-146b-5p CTNNA1 0.631041661167954 6.20366593452965e-08 0.0696920954384375 0.19536330020614 miRanda -0.116166773206056 5.80308092063819e-14 NA NA NA hsa-miR-142-3p CTNNA2 1.53951237846104 2.06769936282034e-17 0.0241619872625858 0.931849795729279 miRanda -0.156840041034896 0.00269455275089307 NA NA NA hsa-miR-361-3p CTNNA2 -0.0370446538644886 0.624902392829872 0.0241619872625858 0.931849795729279 MirTarget -0.36560630464249 0.00462007559061793 NA NA NA hsa-miR-455-5p CTNNA2 0.284641224662773 0.0357572339594277 0.0241619872625858 0.931849795729279 miRanda -0.194214345036707 0.00661178154271556 NA NA NA hsa-miR-589-5p CTNNB1 0.367182541239722 1.67804815542873e-05 -0.339832485209634 2.23758599550069e-07 miRNATAP -0.163417588837067 5.37234569206233e-10 NA NA NA hsa-miR-21-5p DLG1 2.32007501846389 3.08394781855554e-137 -0.261835084228021 4.03142509663786e-05 miRNAWalker2_validate -0.145096003426752 1.51465636451203e-13 NA NA NA hsa-miR-340-5p DLG1 1.0857159627596 4.94471062546756e-24 -0.261835084228021 4.03142509663786e-05 MirTarget -0.115531603209425 4.82904285095236e-09 NA NA NA hsa-let-7g-3p DLG2 0.5854327663695 0.000371711766083627 -1.70773493423543 2.1905000054968e-26 miRNATAP -0.209698968839841 8.50218144817232e-10 NA NA NA hsa-miR-106a-5p DLG2 0.574594373206545 0.000145868284001732 -1.70773493423543 2.1905000054968e-26 mirMAP -0.226599654930839 1.1038925140704e-09 NA NA NA hsa-miR-1301-3p DLG2 1.80754972811286 2.96809840886499e-36 -1.70773493423543 2.1905000054968e-26 MirTarget -0.416156243341087 4.49241350372469e-30 NA NA NA hsa-miR-130b-5p DLG2 1.0573161199584 2.55177349228739e-12 -1.70773493423543 2.1905000054968e-26 miRNATAP -0.315712403529128 4.58422127137959e-18 NA NA NA hsa-miR-142-3p DLG2 1.53951237846104 2.06769936282034e-17 -1.70773493423543 2.1905000054968e-26 miRanda -0.189923677608259 4.41700725012114e-10 NA NA NA hsa-miR-142-5p DLG2 1.16509303143593 1.96641162209073e-13 -1.70773493423543 2.1905000054968e-26 PITA;miRNATAP -0.158292441362038 7.01853943752584e-06 NA NA NA hsa-miR-146b-5p DLG2 0.631041661167954 6.20366593452965e-08 -1.70773493423543 2.1905000054968e-26 miRanda -0.220796065794012 4.94437202844728e-06 NA NA NA hsa-miR-148a-3p DLG2 0.706969798912638 5.52538085480485e-09 -1.70773493423543 2.1905000054968e-26 MirTarget;miRNATAP -0.127719569253626 0.00611171392742673 NA NA NA hsa-miR-148b-3p DLG2 1.0552576751879 1.6679285705231e-29 -1.70773493423543 2.1905000054968e-26 miRNAWalker2_validate;MirTarget -0.468773570168464 5.91836130249082e-16 NA NA NA hsa-miR-15b-3p DLG2 1.12898579025388 1.18050912917317e-14 -1.70773493423543 2.1905000054968e-26 mirMAP -0.363269806134567 2.07619126756147e-22 NA NA NA hsa-miR-16-2-3p DLG2 0.286355254959005 0.0256946046884474 -1.70773493423543 2.1905000054968e-26 mirMAP -0.331808402737894 4.67975271868933e-14 NA NA NA hsa-miR-17-5p DLG2 0.599531757298529 1.07318660415906e-05 -1.70773493423543 2.1905000054968e-26 mirMAP -0.397297730158395 1.13703376343379e-22 NA NA NA hsa-miR-182-5p DLG2 2.36408084103818 2.60011457600281e-72 -1.70773493423543 2.1905000054968e-26 miRNATAP -0.264449158994355 1.34413405114361e-11 NA NA NA hsa-miR-185-5p DLG2 0.482334746589337 3.68475879959415e-09 -1.70773493423543 2.1905000054968e-26 MirTarget;miRNATAP -0.546547948706304 1.21559599126005e-15 NA NA NA hsa-miR-186-5p DLG2 -0.426987301460247 1.04129380549315e-05 -1.70773493423543 2.1905000054968e-26 mirMAP -0.199940762830703 0.00065227518929907 NA NA NA hsa-miR-19a-3p DLG2 0.817507952171848 3.76285090469625e-08 -1.70773493423543 2.1905000054968e-26 mirMAP -0.332396301985709 4.02915820741878e-19 NA NA NA hsa-miR-19b-3p DLG2 0.139124391010031 0.255658553872934 -1.70773493423543 2.1905000054968e-26 mirMAP -0.281400266996424 1.11199931372222e-09 NA NA NA hsa-miR-20a-5p DLG2 0.44979911120222 0.000602386964327228 -1.70773493423543 2.1905000054968e-26 mirMAP -0.343933468116257 6.87699540039088e-16 NA NA NA hsa-miR-20b-5p DLG2 0.78236583455125 8.7938334801223e-05 -1.70773493423543 2.1905000054968e-26 mirMAP -0.136376034733146 1.40820128487305e-06 NA NA NA hsa-miR-22-5p DLG2 0.238328801322329 0.0377496760295305 -1.70773493423543 2.1905000054968e-26 MirTarget;miRNATAP -0.27704154309767 1.97661430372466e-08 NA NA NA hsa-miR-23a-3p DLG2 -0.217176729033818 0.00962615056202409 -1.70773493423543 2.1905000054968e-26 MirTarget;miRNATAP -0.180371402636397 0.00821477750100737 NA NA NA hsa-miR-24-3p DLG2 -0.120123317289941 0.21432376743243 -1.70773493423543 2.1905000054968e-26 MirTarget -0.251733609690761 1.9361266189327e-05 NA NA NA hsa-miR-25-3p DLG2 -0.00546790775985073 0.944061771389468 -1.70773493423543 2.1905000054968e-26 mirMAP -0.348132220118804 2.09688162167133e-06 NA NA NA hsa-miR-28-5p DLG2 -0.14267073663385 0.0497619246260571 -1.70773493423543 2.1905000054968e-26 mirMAP -0.214588108952097 0.00663126365203248 NA NA NA hsa-miR-29b-1-5p DLG2 0.0164831140865254 0.909727358526678 -1.70773493423543 2.1905000054968e-26 mirMAP -0.164916599364568 2.68548375405996e-05 NA NA NA hsa-miR-29b-3p DLG2 0.438847962603729 6.46722433236121e-05 -1.70773493423543 2.1905000054968e-26 MirTarget;miRNATAP -0.275940217159596 8.05020676959687e-08 NA NA NA hsa-miR-3127-5p DLG2 0.903405128081314 1.1325923598273e-12 -1.70773493423543 2.1905000054968e-26 mirMAP -0.220186315664664 5.74828177984804e-07 NA NA NA hsa-miR-32-5p DLG2 1.38676603945192 2.29428299685976e-34 -1.70773493423543 2.1905000054968e-26 mirMAP -0.322234076360038 1.3444230353401e-11 NA NA NA hsa-miR-320b DLG2 0.412787504747938 0.00113457276903985 -1.70773493423543 2.1905000054968e-26 PITA;miRanda;mirMAP;miRNATAP -0.278243986137536 4.61763985463988e-10 NA NA NA hsa-miR-330-3p DLG2 0.432728362037032 0.00041335506960812 -1.70773493423543 2.1905000054968e-26 PITA;mirMAP -0.195011290319604 3.19492376025388e-05 NA NA NA hsa-miR-338-3p DLG2 0.0799903526884966 0.575137668326679 -1.70773493423543 2.1905000054968e-26 PITA;mirMAP;miRNATAP -0.130179156456653 0.001098826690298 NA NA NA hsa-miR-33a-5p DLG2 1.35185127289399 9.80509199125785e-12 -1.70773493423543 2.1905000054968e-26 mirMAP -0.214428920697941 4.56585648096718e-14 NA NA NA hsa-miR-361-3p DLG2 -0.0370446538644886 0.624902392829872 -1.70773493423543 2.1905000054968e-26 PITA;miRNATAP -0.245236661567829 0.00121356862771358 NA NA NA hsa-miR-361-5p DLG2 -0.0996867547900457 0.095428250126326 -1.70773493423543 2.1905000054968e-26 miRanda;mirMAP -0.265147545766842 0.00615663480892182 NA NA NA hsa-miR-3613-5p DLG2 1.11067990676844 4.33424951743633e-21 -1.70773493423543 2.1905000054968e-26 MirTarget;miRNATAP -0.380741389035299 2.34534673385598e-16 NA NA NA hsa-miR-429 DLG2 2.84108892259147 3.88520896426515e-64 -1.70773493423543 2.1905000054968e-26 miRNATAP -0.313645248003662 9.70104576239354e-25 NA NA NA hsa-miR-484 DLG2 0.349444060004737 0.00154491249625173 -1.70773493423543 2.1905000054968e-26 MirTarget;PITA -0.389870443797454 1.69239124640167e-14 NA NA NA hsa-miR-505-5p DLG2 -0.842640534241897 4.43022473091907e-09 -1.70773493423543 2.1905000054968e-26 MirTarget;miRNATAP -0.145521689430836 0.00021541901945814 NA NA NA hsa-miR-576-5p DLG2 0.0649387707567879 0.588791966096287 -1.70773493423543 2.1905000054968e-26 PITA;mirMAP -0.291724383745984 5.70069852091659e-10 NA NA NA hsa-miR-590-3p DLG2 1.27438512890514 1.03164723481469e-23 -1.70773493423543 2.1905000054968e-26 PITA;miRanda;mirMAP -0.408712394217078 4.92719599750518e-20 NA NA NA hsa-miR-590-5p DLG2 0.746515607868274 8.51300479640125e-09 -1.70773493423543 2.1905000054968e-26 PITA;miRanda -0.37845353226227 7.502293488424e-19 NA NA NA hsa-miR-615-3p DLG2 0.659240580933614 0.000360214386152507 -1.70773493423543 2.1905000054968e-26 miRanda -0.146599879785921 1.63202348192167e-06 NA NA NA hsa-miR-7-1-3p DLG2 0.686579567507582 1.20731554448806e-07 -1.70773493423543 2.1905000054968e-26 MirTarget -0.180177350028531 3.39523831851967e-05 NA NA NA hsa-miR-769-5p DLG2 0.564871766265874 8.16695101656941e-10 -1.70773493423543 2.1905000054968e-26 miRNATAP -0.324291603889542 1.15686354576414e-07 NA NA NA hsa-miR-92a-3p DLG2 -0.342420481092807 0.000732275969501111 -1.70773493423543 2.1905000054968e-26 mirMAP -0.256867741988669 4.44648585131078e-06 NA NA NA hsa-miR-92b-3p DLG2 1.30248132773644 9.42428674470985e-25 -1.70773493423543 2.1905000054968e-26 mirMAP -0.340718069395022 1.99710807061145e-15 NA NA NA hsa-miR-93-3p DLG2 0.627759242044891 3.62527588304617e-06 -1.70773493423543 2.1905000054968e-26 MirTarget;miRNATAP -0.382040105993508 8.04805426161752e-21 NA NA NA hsa-miR-125b-2-3p DLG3 -1.92374904783012 2.30779527653582e-38 1.21494513802964 2.93461327640254e-55 mirMAP -0.197600445108251 5.31181548489367e-29 NA NA NA hsa-miR-143-3p DLG3 -1.23248181631499 4.74160976678504e-28 1.21494513802964 2.93461327640254e-55 MirTarget;miRNATAP -0.243406102585405 2.48340082004429e-24 NA NA NA hsa-miR-145-5p DLG3 -2.62703571936687 7.64402900188551e-88 1.21494513802964 2.93461327640254e-55 mirMAP -0.237061088767399 8.12285382637334e-38 NA NA NA hsa-miR-186-5p DLG3 -0.426987301460247 1.04129380549315e-05 1.21494513802964 2.93461327640254e-55 miRNAWalker2_validate -0.115656839477927 8.10304706667811e-05 NA NA NA hsa-miR-197-3p DLG3 -0.526589453596294 3.61594599437195e-06 1.21494513802964 2.93461327640254e-55 mirMAP -0.140132970310923 1.6368929732782e-08 NA NA NA hsa-miR-218-5p DLG3 -1.02621788318234 2.9221925445771e-23 1.21494513802964 2.93461327640254e-55 mirMAP -0.2324518225187 1.21651103703651e-18 NA NA NA hsa-miR-26a-5p DLG3 -0.481180084102235 1.82368246174758e-10 1.21494513802964 2.93461327640254e-55 mirMAP -0.174242837124364 3.4481352265994e-06 NA NA NA hsa-miR-335-5p DLG3 -2.61355235628987 2.6462884165886e-51 1.21494513802964 2.93461327640254e-55 miRNAWalker2_validate -0.120030699315025 2.78819500949539e-15 NA NA NA hsa-miR-374b-5p DLG3 -0.466781429946153 1.17238311619116e-08 1.21494513802964 2.93461327640254e-55 MirTarget -0.164513908888285 2.02225065048787e-06 NA NA NA hsa-miR-500a-3p DLG3 0.139523673241448 0.185528510741158 1.21494513802964 2.93461327640254e-55 MirTarget -0.108594867700374 6.05173009617377e-05 NA NA NA hsa-miR-654-3p DLG3 -1.20494927978695 4.07682448923698e-16 1.21494513802964 2.93461327640254e-55 miRNATAP -0.135795510568056 3.37458084440852e-13 NA NA NA hsa-miR-324-5p DLG4 0.211552647440779 0.139408130311654 0.0526610701097212 0.565670120779663 miRanda;miRNATAP -0.120491024881465 3.23476166852151e-08 NA NA NA hsa-miR-455-3p DLG4 0.678392920628872 0.000327758844555877 0.0526610701097212 0.565670120779663 MirTarget;PITA;miRNATAP -0.121804279369865 8.52372766486592e-14 NA NA NA hsa-miR-10a-5p DVL1 -0.798524155913801 2.99126531473748e-08 0.590824685068987 4.08262080246939e-09 miRNAWalker2_validate -0.107762545824595 6.19772338888115e-06 NA NA NA hsa-miR-30b-3p DVL1 -0.536462824497982 2.41814659272548e-05 0.590824685068987 4.08262080246939e-09 MirTarget -0.115579437179508 2.3800207966178e-05 NA NA NA hsa-miR-339-5p DVL1 -0.211548290465418 0.0685885445822389 0.590824685068987 4.08262080246939e-09 miRanda -0.110559788670663 0.000220610270051997 NA NA NA hsa-let-7a-5p DVL3 -0.210286642041636 0.0072546234707717 0.455328608158929 8.28983754650674e-22 TargetScan -0.103667059737757 1.12037250327915e-06 NA NA NA hsa-miR-106b-5p FBXW11 1.22477789913175 2.31787213143326e-32 -0.316312720644922 6.71697037089303e-08 miRNATAP -0.176360910717368 7.82361659308432e-22 NA NA NA hsa-miR-20a-5p FBXW11 0.44979911120222 0.000602386964327228 -0.316312720644922 6.71697037089303e-08 miRNATAP -0.144291334426437 6.70457379214045e-22 NA NA NA hsa-miR-340-5p FBXW11 1.0857159627596 4.94471062546756e-24 -0.316312720644922 6.71697037089303e-08 mirMAP -0.119257544627908 4.94445433521861e-11 NA NA NA hsa-miR-374a-5p FBXW11 -0.239709888246804 0.00309819667153627 -0.316312720644922 6.71697037089303e-08 mirMAP -0.175519580181888 1.34257782586297e-12 NA NA NA hsa-miR-374b-5p FBXW11 -0.466781429946153 1.17238311619116e-08 -0.316312720644922 6.71697037089303e-08 mirMAP -0.115315723202322 2.61335640229646e-06 NA NA NA hsa-miR-93-5p FBXW11 1.01788600209314 1.24312921618126e-21 -0.316312720644922 6.71697037089303e-08 miRNATAP -0.149796521194947 1.90586895576967e-16 NA NA NA hsa-miR-16-1-3p FGF1 1.30142784811196 2.53343713753744e-29 -2.3363200609921 2.42261900591497e-58 mirMAP -0.581904531746624 8.04220781640102e-38 NA NA NA hsa-miR-186-5p FGF1 -0.426987301460247 1.04129380549315e-05 -2.3363200609921 2.42261900591497e-58 mirMAP -0.143723594837616 0.00933754138773196 NA NA NA hsa-miR-18a-5p FGF1 0.969066793715868 1.69069796425892e-08 -2.3363200609921 2.42261900591497e-58 MirTarget -0.308725947141596 9.70167258927243e-25 NA NA NA hsa-miR-193a-3p FGF1 0.310617999804917 0.00477640270974957 -2.3363200609921 2.42261900591497e-58 PITA -0.19690022881916 5.07868444768763e-05 NA NA NA hsa-miR-21-5p FGF1 2.32007501846389 3.08394781855554e-137 -2.3363200609921 2.42261900591497e-58 MirTarget -0.371477796734357 9.2806521720649e-15 NA NA NA hsa-miR-29a-5p FGF1 0.334183773952055 0.00445137265870197 -2.3363200609921 2.42261900591497e-58 mirMAP -0.152220555461099 0.000862510868875038 NA NA NA hsa-miR-320b FGF1 0.412787504747938 0.00113457276903985 -2.3363200609921 2.42261900591497e-58 miRanda -0.230047658868655 4.79239651855213e-08 NA NA NA hsa-miR-330-5p FGF1 0.626063225953928 3.42215028606779e-09 -2.3363200609921 2.42261900591497e-58 miRanda;miRNATAP -0.320213335163115 1.22351851936422e-10 NA NA NA hsa-miR-361-5p FGF1 -0.0996867547900457 0.095428250126326 -2.3363200609921 2.42261900591497e-58 miRanda -0.324186160458905 0.000365896398010837 NA NA NA hsa-miR-3913-5p FGF1 0.71890413546147 2.61153227160465e-13 -2.3363200609921 2.42261900591497e-58 mirMAP -0.147478952504203 0.00632555140399931 NA NA NA hsa-miR-429 FGF1 2.84108892259147 3.88520896426515e-64 -2.3363200609921 2.42261900591497e-58 miRNATAP -0.325212393355327 4.60753740095485e-30 NA NA NA hsa-miR-484 FGF1 0.349444060004737 0.00154491249625173 -2.3363200609921 2.42261900591497e-58 MirTarget;PITA;miRNATAP -0.350837387269644 2.42230585979755e-13 NA NA NA hsa-miR-532-3p FGF1 -0.395473145042459 0.00686714288452761 -2.3363200609921 2.42261900591497e-58 miRNATAP -0.135400728049064 0.000208318514603032 NA NA NA hsa-miR-550a-5p FGF1 -0.12364998419382 0.410467966112492 -2.3363200609921 2.42261900591497e-58 MirTarget -0.124015992653408 0.000650072833531158 NA NA NA hsa-miR-576-5p FGF1 0.0649387707567879 0.588791966096287 -2.3363200609921 2.42261900591497e-58 PITA;mirMAP -0.195551405525261 1.13745464101402e-05 NA NA NA hsa-miR-590-5p FGF1 0.746515607868274 8.51300479640125e-09 -2.3363200609921 2.42261900591497e-58 MirTarget;miRanda;miRNATAP -0.370669749508457 2.36068553671594e-20 NA NA NA hsa-miR-625-5p FGF1 0.728939236913178 5.97591217674307e-08 -2.3363200609921 2.42261900591497e-58 MirTarget -0.241254403404484 2.5870605302491e-09 NA NA NA hsa-miR-629-5p FGF1 0.42411327890895 2.46262300605706e-05 -2.3363200609921 2.42261900591497e-58 MirTarget -0.28293563961806 8.96106894697866e-08 NA NA NA hsa-miR-330-5p FRMD1 0.626063225953928 3.42215028606779e-09 -4.43128852319024 7.07387110304691e-68 miRanda -0.711122602468534 5.34844538060021e-16 NA NA NA hsa-miR-342-5p FRMD1 1.49554286219821 1.56221300255782e-22 -4.43128852319024 7.07387110304691e-68 mirMAP -0.285061876098883 2.20788394841257e-06 NA NA NA hsa-let-7a-3p FRMD6 0.466622567891891 3.70886257943079e-07 -0.866699035031564 6.18218400177215e-15 MirTarget;mirMAP -0.135851903874081 0.00125406651536403 NA NA NA hsa-miR-106a-5p FRMD6 0.574594373206545 0.000145868284001732 -0.866699035031564 6.18218400177215e-15 MirTarget;miRNATAP -0.134151034608007 1.26347486421622e-07 NA NA NA hsa-miR-106b-5p FRMD6 1.22477789913175 2.31787213143326e-32 -0.866699035031564 6.18218400177215e-15 MirTarget;miRNATAP -0.532312395497714 2.85319622853044e-56 NA NA NA hsa-miR-130b-3p FRMD6 1.38122163823846 1.00932179737836e-26 -0.866699035031564 6.18218400177215e-15 MirTarget -0.278569063842757 1.5175593157196e-22 NA NA NA hsa-miR-141-3p FRMD6 2.99777540204168 1.26370498493024e-78 -0.866699035031564 6.18218400177215e-15 MirTarget;TargetScan;miRNATAP -0.210703663785569 6.94058503459482e-23 NA NA NA hsa-miR-146a-5p FRMD6 0.102405752365098 0.486975378688068 -0.866699035031564 6.18218400177215e-15 MirTarget -0.112183663248912 1.91003495946637e-05 NA NA NA hsa-miR-146b-5p FRMD6 0.631041661167954 6.20366593452965e-08 -0.866699035031564 6.18218400177215e-15 MirTarget;miRanda -0.132041130080758 6.18295646194644e-05 NA NA NA hsa-miR-148a-5p FRMD6 0.572692271754695 2.14306251522796e-06 -0.866699035031564 6.18218400177215e-15 miRNATAP -0.132101334161223 3.35018604192587e-05 NA NA NA hsa-miR-15b-3p FRMD6 1.12898579025388 1.18050912917317e-14 -0.866699035031564 6.18218400177215e-15 mirMAP -0.271570792370086 5.49825857655181e-27 NA NA NA hsa-miR-16-2-3p FRMD6 0.286355254959005 0.0256946046884474 -0.866699035031564 6.18218400177215e-15 mirMAP -0.289837074581797 1.31558309876348e-22 NA NA NA hsa-miR-17-5p FRMD6 0.599531757298529 1.07318660415906e-05 -0.866699035031564 6.18218400177215e-15 MirTarget;TargetScan;miRNATAP -0.362486387698232 2.82224565401017e-41 NA NA NA hsa-miR-183-5p FRMD6 2.95681814393872 1.09965777344285e-92 -0.866699035031564 6.18218400177215e-15 MirTarget;miRNATAP -0.167932669842187 9.06663739237668e-13 NA NA NA hsa-miR-200a-3p FRMD6 2.55218480823434 2.96135446816238e-51 -0.866699035031564 6.18218400177215e-15 MirTarget;miRNATAP -0.16417507171658 1.01344056716179e-14 NA NA NA hsa-miR-200b-3p FRMD6 2.11744072703209 1.66710572104191e-43 -0.866699035031564 6.18218400177215e-15 TargetScan -0.151525640921733 1.71424374610769e-10 NA NA NA hsa-miR-200c-3p FRMD6 2.07038651806183 6.84613386286599e-51 -0.866699035031564 6.18218400177215e-15 miRNATAP -0.208288866495126 9.17125871002378e-16 NA NA NA hsa-miR-20a-5p FRMD6 0.44979911120222 0.000602386964327228 -0.866699035031564 6.18218400177215e-15 MirTarget;miRNATAP -0.374185090436214 1.65453877837232e-40 NA NA NA hsa-miR-27a-3p FRMD6 0.388496361379095 1.42373532086331e-05 -0.866699035031564 6.18218400177215e-15 miRNATAP -0.138146972371955 0.0014178778788683 NA NA NA hsa-miR-301a-3p FRMD6 1.32170168375632 2.12280368957514e-15 -0.866699035031564 6.18218400177215e-15 MirTarget -0.254532811698118 1.79659074882789e-30 NA NA NA hsa-miR-30b-5p FRMD6 -0.46540603860146 2.4709940429591e-05 -0.866699035031564 6.18218400177215e-15 MirTarget -0.113646681240044 0.00117369847487119 NA NA NA hsa-miR-30c-5p FRMD6 -0.393222674580066 8.06961465717306e-05 -0.866699035031564 6.18218400177215e-15 MirTarget;miRNATAP -0.104621086466329 0.00709368420021134 NA NA NA hsa-miR-30d-5p FRMD6 -0.247082219011045 0.00406717930063148 -0.866699035031564 6.18218400177215e-15 MirTarget;miRNATAP -0.189244684352834 2.75429484612472e-05 NA NA NA hsa-miR-30e-5p FRMD6 0.293491764699475 0.000372291967271834 -0.866699035031564 6.18218400177215e-15 MirTarget -0.407812763983127 1.12081554920905e-18 NA NA NA hsa-miR-320b FRMD6 0.412787504747938 0.00113457276903985 -0.866699035031564 6.18218400177215e-15 miRanda -0.154717032315517 3.98799458764966e-07 NA NA NA hsa-miR-340-5p FRMD6 1.0857159627596 4.94471062546756e-24 -0.866699035031564 6.18218400177215e-15 MirTarget -0.294248095187444 1.4995162145893e-17 NA NA NA hsa-miR-3613-5p FRMD6 1.11067990676844 4.33424951743633e-21 -0.866699035031564 6.18218400177215e-15 miRNATAP -0.205956555748726 9.88689134763142e-11 NA NA NA hsa-miR-374a-5p FRMD6 -0.239709888246804 0.00309819667153627 -0.866699035031564 6.18218400177215e-15 mirMAP -0.141574303307166 0.00323074771367386 NA NA NA hsa-miR-429 FRMD6 2.84108892259147 3.88520896426515e-64 -0.866699035031564 6.18218400177215e-15 miRanda;miRNATAP -0.180281356981335 8.71143077479489e-18 NA NA NA hsa-miR-454-3p FRMD6 1.28177672191095 6.84024979484587e-21 -0.866699035031564 6.18218400177215e-15 MirTarget -0.268438654614896 4.17064621478634e-23 NA NA NA hsa-miR-590-3p FRMD6 1.27438512890514 1.03164723481469e-23 -0.866699035031564 6.18218400177215e-15 miRanda -0.317324161783344 6.04276036193163e-26 NA NA NA hsa-miR-671-5p FRMD6 1.55248047544015 7.7377784125886e-33 -0.866699035031564 6.18218400177215e-15 MirTarget -0.332526095957469 2.41615269601697e-32 NA NA NA hsa-miR-7-1-3p FRMD6 0.686579567507582 1.20731554448806e-07 -0.866699035031564 6.18218400177215e-15 MirTarget -0.139998758500978 2.16031033234228e-06 NA NA NA hsa-miR-9-5p FRMD6 0.734772328078424 0.00261982843636383 -0.866699035031564 6.18218400177215e-15 MirTarget;miRNATAP -0.119889615322065 1.36607364999636e-14 NA NA NA hsa-miR-93-5p FRMD6 1.01788600209314 1.24312921618126e-21 -0.866699035031564 6.18218400177215e-15 MirTarget;miRNATAP -0.51129869288291 2.77777904269598e-53 NA NA NA hsa-miR-29b-3p FZD1 0.438847962603729 6.46722433236121e-05 -0.348990746009524 0.000632040029652186 mirMAP -0.142292816540562 7.62954986745634e-06 NA NA NA hsa-miR-29c-3p FZD1 -0.0652732378039769 0.563774115756922 -0.348990746009524 0.000632040029652186 mirMAP -0.218168403933287 1.2823801399907e-12 NA NA NA hsa-miR-107 FZD10 0.678998026350662 2.56224148930538e-16 -0.317555738920769 0.0719106519916973 miRanda -0.400790225805032 2.23315200602984e-08 NA NA NA hsa-miR-15b-5p FZD10 0.788659356634696 1.13678211092534e-11 -0.317555738920769 0.0719106519916973 miRNATAP -0.294791552759113 8.30312298544766e-09 NA NA NA hsa-miR-16-5p FZD10 0.46835991343556 1.91125356547776e-06 -0.317555738920769 0.0719106519916973 miRNATAP -0.205587202208207 0.000809635155549991 NA NA NA hsa-miR-25-3p FZD10 -0.00546790775985073 0.944061771389468 -0.317555738920769 0.0719106519916973 miRNATAP -0.348866342513126 7.96845323691697e-06 NA NA NA hsa-miR-455-3p FZD10 0.678392920628872 0.000327758844555877 -0.317555738920769 0.0719106519916973 PITA;miRNATAP -0.126579766449709 7.04423244264842e-05 NA NA NA hsa-miR-92a-3p FZD10 -0.342420481092807 0.000732275969501111 -0.317555738920769 0.0719106519916973 miRNATAP -0.296950048447328 5.92314304840851e-07 NA NA NA hsa-miR-92b-3p FZD10 1.30248132773644 9.42428674470985e-25 -0.317555738920769 0.0719106519916973 miRNATAP -0.138813280698489 0.00275447570293217 NA NA NA hsa-miR-98-5p FZD10 0.656336869298973 9.03113188590466e-15 -0.317555738920769 0.0719106519916973 miRNAWalker2_validate -0.461667265087064 4.29163451584181e-11 NA NA NA hsa-miR-103a-3p FZD3 0.610673390034345 1.63113920514646e-12 0.141330043289239 0.271890100649809 MirTarget -0.217217198769376 1.65600292637449e-05 NA NA NA hsa-miR-107 FZD3 0.678998026350662 2.56224148930538e-16 0.141330043289239 0.271890100649809 MirTarget;miRanda -0.179768540730773 0.00061594712979082 NA NA NA hsa-miR-139-5p FZD3 -3.25846663863766 2.62018989415003e-112 0.141330043289239 0.271890100649809 PITA;miRanda -0.114417639453248 1.43759918418206e-05 NA NA NA hsa-miR-16-2-3p FZD3 0.286355254959005 0.0256946046884474 0.141330043289239 0.271890100649809 mirMAP -0.131652726734944 0.000136576830732616 NA NA NA hsa-miR-335-3p FZD3 -1.88448538773649 2.09538234398335e-32 0.141330043289239 0.271890100649809 MirTarget;mirMAP -0.113655440180937 1.86044682903159e-05 NA NA NA hsa-miR-338-3p FZD3 0.0799903526884966 0.575137668326679 0.141330043289239 0.271890100649809 PITA;miRanda -0.111182152623386 0.000317238435661394 NA NA NA hsa-miR-361-5p FZD3 -0.0996867547900457 0.095428250126326 0.141330043289239 0.271890100649809 miRanda;miRNATAP -0.262866332902642 0.000447138915298169 NA NA NA hsa-miR-374a-5p FZD3 -0.239709888246804 0.00309819667153627 0.141330043289239 0.271890100649809 mirMAP -0.182913725946331 0.00081843481388181 NA NA NA hsa-let-7a-3p FZD4 0.466622567891891 3.70886257943079e-07 -2.45778080887863 8.2466362913083e-83 mirMAP -0.407977804308959 4.19813220404563e-15 NA NA NA hsa-let-7d-5p FZD4 0.410958462607207 6.07808182756787e-06 -2.45778080887863 8.2466362913083e-83 MirTarget;miRNATAP -0.378548770288792 7.31572406282056e-13 NA NA NA hsa-let-7f-1-3p FZD4 0.37532726250321 0.00156021688753682 -2.45778080887863 8.2466362913083e-83 mirMAP -0.196958732723448 1.81775392431145e-06 NA NA NA hsa-let-7g-3p FZD4 0.5854327663695 0.000371711766083627 -2.45778080887863 8.2466362913083e-83 MirTarget;miRNATAP -0.181060509538746 5.2893212751556e-10 NA NA NA hsa-miR-106b-5p FZD4 1.22477789913175 2.31787213143326e-32 -2.45778080887863 8.2466362913083e-83 miRNATAP -0.578879980215605 3.05048677233544e-41 NA NA NA hsa-miR-107 FZD4 0.678998026350662 2.56224148930538e-16 -2.45778080887863 8.2466362913083e-83 miRNATAP -0.462830534136136 4.14785600961069e-16 NA NA NA hsa-miR-130b-3p FZD4 1.38122163823846 1.00932179737836e-26 -2.45778080887863 8.2466362913083e-83 mirMAP -0.413297584170443 1.17616241857261e-31 NA NA NA hsa-miR-141-3p FZD4 2.99777540204168 1.26370498493024e-78 -2.45778080887863 8.2466362913083e-83 TargetScan -0.485144243770508 8.88244662789011e-86 NA NA NA hsa-miR-15a-5p FZD4 0.812445324157528 4.50263417099822e-20 -2.45778080887863 8.2466362913083e-83 MirTarget -0.396430785367124 8.19331587254851e-14 NA NA NA hsa-miR-15b-5p FZD4 0.788659356634696 1.13678211092534e-11 -2.45778080887863 8.2466362913083e-83 MirTarget -0.335171646720997 1.57029090717913e-16 NA NA NA hsa-miR-16-5p FZD4 0.46835991343556 1.91125356547776e-06 -2.45778080887863 8.2466362913083e-83 MirTarget -0.244461027478749 6.1956298490801e-07 NA NA NA hsa-miR-17-3p FZD4 0.721439431208839 7.95900548819742e-10 -2.45778080887863 8.2466362913083e-83 MirTarget -0.488528178794328 1.80113152001825e-35 NA NA NA hsa-miR-17-5p FZD4 0.599531757298529 1.07318660415906e-05 -2.45778080887863 8.2466362913083e-83 TargetScan -0.379930791437764 1.81308518580408e-28 NA NA NA hsa-miR-185-5p FZD4 0.482334746589337 3.68475879959415e-09 -2.45778080887863 8.2466362913083e-83 MirTarget -0.32822571943949 2.4240703164448e-08 NA NA NA hsa-miR-192-5p FZD4 1.33366224451777 9.5116159697107e-29 -2.45778080887863 8.2466362913083e-83 miRNAWalker2_validate;mirMAP -0.417317983267879 3.23659392050309e-28 NA NA NA hsa-miR-200b-3p FZD4 2.11744072703209 1.66710572104191e-43 -2.45778080887863 8.2466362913083e-83 mirMAP -0.443472478111004 1.62241648876776e-56 NA NA NA hsa-miR-200c-3p FZD4 2.07038651806183 6.84613386286599e-51 -2.45778080887863 8.2466362913083e-83 mirMAP -0.5394698778619 2.40222703670541e-71 NA NA NA hsa-miR-20a-5p FZD4 0.44979911120222 0.000602386964327228 -2.45778080887863 8.2466362913083e-83 miRNATAP -0.349126822049724 3.50595644995987e-22 NA NA NA hsa-miR-21-5p FZD4 2.32007501846389 3.08394781855554e-137 -2.45778080887863 8.2466362913083e-83 mirMAP -0.617423104849022 4.14640575991911e-50 NA NA NA hsa-miR-212-3p FZD4 0.24081906669865 0.0571447155653209 -2.45778080887863 8.2466362913083e-83 mirMAP -0.106820495464605 0.0061660372674424 NA NA NA hsa-miR-25-3p FZD4 -0.00546790775985073 0.944061771389468 -2.45778080887863 8.2466362913083e-83 mirMAP -0.311311688515217 6.52111955612921e-07 NA NA NA hsa-miR-27a-3p FZD4 0.388496361379095 1.42373532086331e-05 -2.45778080887863 8.2466362913083e-83 miRNATAP -0.332335163103274 6.55789467955252e-10 NA NA NA hsa-miR-301a-3p FZD4 1.32170168375632 2.12280368957514e-15 -2.45778080887863 8.2466362913083e-83 mirMAP -0.296293129313005 3.03122689456589e-26 NA NA NA hsa-miR-3065-3p FZD4 1.62787885002468 6.81477830005026e-19 -2.45778080887863 8.2466362913083e-83 mirMAP -0.21363490263864 4.05907439854592e-17 NA NA NA hsa-miR-3127-5p FZD4 0.903405128081314 1.1325923598273e-12 -2.45778080887863 8.2466362913083e-83 MirTarget -0.353612933288253 8.25127810305334e-22 NA NA NA hsa-miR-32-5p FZD4 1.38676603945192 2.29428299685976e-34 -2.45778080887863 8.2466362913083e-83 mirMAP -0.393954741435993 7.79828021744844e-23 NA NA NA hsa-miR-324-3p FZD4 0.404877731996915 0.000340036423920834 -2.45778080887863 8.2466362913083e-83 miRNATAP -0.308721358633824 3.19173797166468e-13 NA NA NA hsa-miR-330-5p FZD4 0.626063225953928 3.42215028606779e-09 -2.45778080887863 8.2466362913083e-83 miRanda;miRNATAP -0.413410414565267 1.56474033349077e-20 NA NA NA hsa-miR-361-3p FZD4 -0.0370446538644886 0.624902392829872 -2.45778080887863 8.2466362913083e-83 MirTarget -0.210274672274026 0.00114713669929094 NA NA NA hsa-miR-429 FZD4 2.84108892259147 3.88520896426515e-64 -2.45778080887863 8.2466362913083e-83 mirMAP -0.419642690763874 1.62254290929758e-64 NA NA NA hsa-miR-454-3p FZD4 1.28177672191095 6.84024979484587e-21 -2.45778080887863 8.2466362913083e-83 mirMAP -0.33333483404347 1.07749136844395e-22 NA NA NA hsa-miR-455-3p FZD4 0.678392920628872 0.000327758844555877 -2.45778080887863 8.2466362913083e-83 mirMAP -0.187203964079631 1.23489599175754e-13 NA NA NA hsa-miR-484 FZD4 0.349444060004737 0.00154491249625173 -2.45778080887863 8.2466362913083e-83 PITA -0.212116451539721 1.28850151052031e-06 NA NA NA hsa-miR-576-5p FZD4 0.0649387707567879 0.588791966096287 -2.45778080887863 8.2466362913083e-83 mirMAP -0.1856965803836 4.20641790446917e-06 NA NA NA hsa-miR-582-5p FZD4 0.201134299470983 0.149482495292227 -2.45778080887863 8.2466362913083e-83 PITA;miRNATAP -0.128558705031842 0.000254827247268146 NA NA NA hsa-miR-590-3p FZD4 1.27438512890514 1.03164723481469e-23 -2.45778080887863 8.2466362913083e-83 miRanda;mirMAP;miRNATAP -0.406671608133116 3.85657572987706e-27 NA NA NA hsa-miR-590-5p FZD4 0.746515607868274 8.51300479640125e-09 -2.45778080887863 8.2466362913083e-83 mirMAP -0.331595766851545 7.67537979959466e-20 NA NA NA hsa-miR-629-3p FZD4 1.25035919247365 3.91361135469024e-14 -2.45778080887863 8.2466362913083e-83 miRNATAP -0.23213209252431 2.89292527551865e-15 NA NA NA hsa-miR-7-1-3p FZD4 0.686579567507582 1.20731554448806e-07 -2.45778080887863 8.2466362913083e-83 mirMAP -0.224934472313498 1.05455748906568e-09 NA NA NA hsa-miR-92a-3p FZD4 -0.342420481092807 0.000732275969501111 -2.45778080887863 8.2466362913083e-83 mirMAP -0.301979533216699 2.02325930056432e-10 NA NA NA hsa-miR-92b-3p FZD4 1.30248132773644 9.42428674470985e-25 -2.45778080887863 8.2466362913083e-83 mirMAP -0.348983639703719 6.88519966120482e-22 NA NA NA hsa-miR-98-5p FZD4 0.656336869298973 9.03113188590466e-15 -2.45778080887863 8.2466362913083e-83 MirTarget -0.528062971038367 1.52945921080448e-21 NA NA NA hsa-miR-194-5p FZD5 0.467781870340114 1.0386810618625e-07 -1.30576854554188 8.3393662705584e-32 miRNATAP -0.178831539257334 6.90395730167637e-05 NA NA NA hsa-miR-200a-3p FZD5 2.55218480823434 2.96135446816238e-51 -1.30576854554188 8.3393662705584e-32 mirMAP -0.193303591193815 3.54560151752924e-19 NA NA NA hsa-miR-342-3p FZD5 1.21944481975657 6.81914373001202e-19 -1.30576854554188 8.3393662705584e-32 PITA -0.25230820365646 7.06125013894829e-20 NA NA NA hsa-miR-450b-5p FZD5 0.781564228875267 3.90462514315383e-11 -1.30576854554188 8.3393662705584e-32 mirMAP -0.162494214108962 8.75558752610779e-07 NA NA NA hsa-miR-493-5p FZD5 1.25321217062116 2.58094342947875e-18 -1.30576854554188 8.3393662705584e-32 mirMAP -0.148378073973601 4.37435544088392e-08 NA NA NA hsa-miR-101-3p FZD6 -0.126035286271986 0.145997832808138 -0.245458286479777 0.0729026487995083 miRNAWalker2_validate;MirTarget -0.18427726420101 0.00071074749259132 NA NA NA hsa-miR-194-5p FZD6 0.467781870340114 1.0386810618625e-07 -0.245458286479777 0.0729026487995083 MirTarget -0.1574113672057 0.003131819177647 NA NA NA hsa-miR-192-5p FZD7 1.33366224451777 9.5116159697107e-29 -1.37883556350474 1.57806088531265e-27 miRNAWalker2_validate -0.161936601307415 7.47545781365299e-06 NA NA NA hsa-miR-338-3p FZD7 0.0799903526884966 0.575137668326679 -1.37883556350474 1.57806088531265e-27 miRanda -0.141146838960966 7.12302368603286e-06 NA NA NA hsa-miR-429 FZD7 2.84108892259147 3.88520896426515e-64 -1.37883556350474 1.57806088531265e-27 miRanda;miRNATAP -0.118345789299754 1.70567166199748e-06 NA NA NA hsa-miR-590-3p FZD7 1.27438512890514 1.03164723481469e-23 -1.37883556350474 1.57806088531265e-27 miRanda -0.113468728152917 0.0016315686222763 NA NA NA hsa-miR-324-5p FZD8 0.211552647440779 0.139408130311654 -0.451402348278936 0.00210719128371962 miRanda -0.112580820578128 0.00139833151556216 NA NA NA hsa-miR-590-3p FZD8 1.27438512890514 1.03164723481469e-23 -0.451402348278936 0.00210719128371962 miRanda -0.187080083941158 3.36973671342903e-06 NA NA NA hsa-miR-7-1-3p FZD8 0.686579567507582 1.20731554448806e-07 -0.451402348278936 0.00210719128371962 MirTarget -0.285864089758394 6.15672183615667e-14 NA NA NA hsa-miR-99b-5p FZD8 0.286053025104474 0.0059164652978285 -0.451402348278936 0.00210719128371962 MirTarget -0.27167361740119 1.84979575053296e-08 NA NA NA hsa-miR-342-3p GDF5 1.21944481975657 6.81914373001202e-19 -2.29225103887934 1.9647166261975e-19 miRanda -0.50811169463946 4.33189323314316e-16 NA NA NA hsa-let-7d-5p GDF6 0.410958462607207 6.07808182756787e-06 -0.388623710302829 0.0268119680640758 MirTarget;miRNATAP -0.176724465068045 0.00771130569639958 NA NA NA hsa-let-7g-5p GDF6 0.0200025784917734 0.791635298815256 -0.388623710302829 0.0268119680640758 MirTarget;miRNATAP -0.211224881140262 0.00858834057253194 NA NA NA hsa-miR-141-3p GDF6 2.99777540204168 1.26370498493024e-78 -0.388623710302829 0.0268119680640758 TargetScan -0.245691412390661 3.02382137529226e-13 NA NA NA hsa-miR-141-5p GDF6 2.38411349683216 4.56310582620282e-58 -0.388623710302829 0.0268119680640758 mirMAP -0.215895062193741 8.08164935094237e-09 NA NA NA hsa-miR-148a-3p GDF6 0.706969798912638 5.52538085480485e-09 -0.388623710302829 0.0268119680640758 miRNATAP -0.209173958939414 2.08641938433008e-05 NA NA NA hsa-miR-193a-3p GDF6 0.310617999804917 0.00477640270974957 -0.388623710302829 0.0268119680640758 miRanda -0.290674999402467 9.37034296350216e-08 NA NA NA hsa-miR-200b-3p GDF6 2.11744072703209 1.66710572104191e-43 -0.388623710302829 0.0268119680640758 TargetScan -0.235189970868671 1.83473115362667e-10 NA NA NA hsa-miR-30d-3p GDF6 0.264544633563642 0.00755023189129747 -0.388623710302829 0.0268119680640758 miRNATAP -0.286565347127467 2.41745328700732e-06 NA NA NA hsa-miR-324-5p GDF6 0.211552647440779 0.139408130311654 -0.388623710302829 0.0268119680640758 miRanda -0.184054486893969 1.15350981651547e-05 NA NA NA hsa-miR-330-3p GDF6 0.432728362037032 0.00041335506960812 -0.388623710302829 0.0268119680640758 PITA;miRNATAP -0.168151107267975 0.000719056491443551 NA NA NA hsa-miR-339-5p GDF6 -0.211548290465418 0.0685885445822389 -0.388623710302829 0.0268119680640758 miRanda -0.192415748893717 0.000207169195414695 NA NA NA hsa-miR-429 GDF6 2.84108892259147 3.88520896426515e-64 -0.388623710302829 0.0268119680640758 PITA;miRanda;miRNATAP -0.195401437731195 3.19568062685289e-09 NA NA NA hsa-miR-532-3p GDF6 -0.395473145042459 0.00686714288452761 -0.388623710302829 0.0268119680640758 PITA;miRNATAP -0.165327279580597 5.57617374827518e-05 NA NA NA hsa-miR-590-3p GDF6 1.27438512890514 1.03164723481469e-23 -0.388623710302829 0.0268119680640758 miRanda;mirMAP -0.26694954665499 2.56785783669174e-08 NA NA NA hsa-miR-98-5p GDF6 0.656336869298973 9.03113188590466e-15 -0.388623710302829 0.0268119680640758 MirTarget -0.289588587887271 3.72588812074349e-05 NA NA NA hsa-miR-141-3p GLI2 2.99777540204168 1.26370498493024e-78 -0.809812833399723 1.77977002621718e-08 MirTarget -0.333509982639127 5.41463993853588e-35 NA NA NA hsa-miR-15b-3p GLI2 1.12898579025388 1.18050912917317e-14 -0.809812833399723 1.77977002621718e-08 mirMAP -0.286974385348798 2.01180744515371e-18 NA NA NA hsa-miR-182-5p GLI2 2.36408084103818 2.60011457600281e-72 -0.809812833399723 1.77977002621718e-08 MirTarget -0.291684858992199 7.42083673403218e-18 NA NA NA hsa-miR-200a-3p GLI2 2.55218480823434 2.96135446816238e-51 -0.809812833399723 1.77977002621718e-08 MirTarget -0.276570337072336 7.57698921345758e-25 NA NA NA hsa-miR-26b-5p GLI2 -0.331527896896866 0.000551258576575092 -0.809812833399723 1.77977002621718e-08 miRNAWalker2_validate -0.155728865147985 0.00269091058962083 NA NA NA hsa-miR-30b-5p GLI2 -0.46540603860146 2.4709940429591e-05 -0.809812833399723 1.77977002621718e-08 MirTarget -0.26771068308781 1.96104567950639e-09 NA NA NA hsa-miR-30c-5p GLI2 -0.393222674580066 8.06961465717306e-05 -0.809812833399723 1.77977002621718e-08 MirTarget -0.238895419219586 1.48953367666364e-06 NA NA NA hsa-miR-30d-5p GLI2 -0.247082219011045 0.00406717930063148 -0.809812833399723 1.77977002621718e-08 MirTarget -0.321825101666159 2.43756389260761e-08 NA NA NA hsa-miR-30e-5p GLI2 0.293491764699475 0.000372291967271834 -0.809812833399723 1.77977002621718e-08 MirTarget -0.314466916002593 1.76532026866048e-07 NA NA NA hsa-miR-320b GLI2 0.412787504747938 0.00113457276903985 -0.809812833399723 1.77977002621718e-08 miRanda -0.146676274696201 0.000190274890714232 NA NA NA hsa-miR-330-5p GLI2 0.626063225953928 3.42215028606779e-09 -0.809812833399723 1.77977002621718e-08 MirTarget -0.316061750321094 7.16402130055035e-12 NA NA NA hsa-miR-3607-3p GLI2 0.00697875745616461 0.972073275173643 -0.809812833399723 1.77977002621718e-08 miRNATAP -0.107650372595476 1.48139513782778e-05 NA NA NA hsa-miR-501-3p GLI2 0.0448022813406874 0.711710441403614 -0.809812833399723 1.77977002621718e-08 MirTarget;miRNATAP -0.195878552609754 1.73952736964405e-06 NA NA NA hsa-miR-502-3p GLI2 0.11461741546458 0.276553832470138 -0.809812833399723 1.77977002621718e-08 MirTarget;miRNATAP -0.128146953347449 0.00688696173664666 NA NA NA hsa-miR-664a-3p GLI2 -0.237699857923843 0.0197071390183375 -0.809812833399723 1.77977002621718e-08 MirTarget -0.287597148356491 3.10616700591533e-09 NA NA NA hsa-miR-101-3p GSK3B -0.126035286271986 0.145997832808138 0.16507499183074 0.0104993269942212 miRNATAP -0.1804025732635 1.07790099640944e-12 NA NA NA hsa-miR-181a-5p GSK3B 0.635863607630183 6.72486918157744e-11 0.16507499183074 0.0104993269942212 mirMAP -0.116539047078398 1.93667948800215e-07 NA NA NA hsa-miR-26a-5p GSK3B -0.481180084102235 1.82368246174758e-10 0.16507499183074 0.0104993269942212 miRNAWalker2_validate;miRNATAP -0.275908606747704 3.58443650423207e-22 NA NA NA hsa-miR-29a-3p GSK3B -0.699539666833076 1.13935003139957e-13 0.16507499183074 0.0104993269942212 miRNATAP -0.20395154397803 2.73691130456682e-19 NA NA NA hsa-miR-29c-3p GSK3B -0.0652732378039769 0.563774115756922 0.16507499183074 0.0104993269942212 miRNATAP -0.148921210430456 1.24088422020447e-14 NA NA NA hsa-miR-320a GSK3B -0.287921276129346 0.00141693637596294 0.16507499183074 0.0104993269942212 miRanda;mirMAP -0.129942826481556 1.0429094971177e-07 NA NA NA hsa-miR-340-5p GSK3B 1.0857159627596 4.94471062546756e-24 0.16507499183074 0.0104993269942212 mirMAP -0.119708017508741 1.77864671732598e-09 NA NA NA hsa-miR-374a-5p GSK3B -0.239709888246804 0.00309819667153627 0.16507499183074 0.0104993269942212 mirMAP -0.161835653986741 2.7137832607523e-09 NA NA NA hsa-miR-542-3p GSK3B 0.568822103820889 8.5699075257651e-07 0.16507499183074 0.0104993269942212 miRanda -0.110477181605807 5.02640445089489e-09 NA NA NA hsa-let-7a-3p ID1 0.466622567891891 3.70886257943079e-07 -1.07844448572194 4.92075309042249e-15 MirTarget;miRNATAP -0.288666797905502 2.68339123612235e-08 NA NA NA hsa-let-7b-3p ID1 -0.778498268330274 1.04357662300776e-10 -1.07844448572194 4.92075309042249e-15 MirTarget;miRNATAP -0.213661368629314 5.17627112591308e-08 NA NA NA hsa-let-7f-1-3p ID1 0.37532726250321 0.00156021688753682 -1.07844448572194 4.92075309042249e-15 MirTarget -0.168472615663934 3.82568771699861e-05 NA NA NA hsa-miR-16-2-3p ID1 0.286355254959005 0.0256946046884474 -1.07844448572194 4.92075309042249e-15 MirTarget -0.106045291832553 0.00490760564452169 NA NA NA hsa-miR-192-5p ID1 1.33366224451777 9.5116159697107e-29 -1.07844448572194 4.92075309042249e-15 miRNAWalker2_validate -0.376309448355852 2.01378377203536e-23 NA NA NA hsa-miR-29b-3p ID1 0.438847962603729 6.46722433236121e-05 -1.07844448572194 4.92075309042249e-15 MirTarget -0.188784664946449 1.46064015731403e-05 22249264;24662327 Incubation of lung cancer cells with the Src inhibitor saracatinib led to the upregulation of several miRNAs including miR-29b which was the most highly upregulated miRNA with predicted binding to the ID1 3'-untranslated region UTR; Luciferase reporter assays confirmed direct binding of miR-29b to the ID1 3'-UTR; Expression of miR-29b suppressed ID1 levels and significantly reduced migration and invasion;Id 1 a protein repressed by miR 29b facilitates the TGFβ1 induced epithelial mesenchymal transition in human ovarian cancer cells ; lung cancer;ovarian cancer hsa-miR-330-5p ID1 0.626063225953928 3.42215028606779e-09 -1.07844448572194 4.92075309042249e-15 miRNATAP -0.286099397613906 1.45878882256605e-10 NA NA NA hsa-miR-331-3p ID1 0.74441480542886 1.17071235477799e-07 -1.07844448572194 4.92075309042249e-15 MirTarget -0.386656508179256 2.65685537692846e-32 NA NA NA hsa-miR-125a-5p ITGB2 -0.635694700253268 3.6703235721638e-11 0.781200680713074 7.58249713982613e-10 miRanda -0.395044218010862 6.75917484371185e-19 NA NA NA hsa-miR-335-5p ITGB2 -2.61355235628987 2.6462884165886e-51 0.781200680713074 7.58249713982613e-10 miRNAWalker2_validate -0.15054300422263 1.7626731050026e-10 NA NA NA hsa-miR-103a-3p LATS1 0.610673390034345 1.63113920514646e-12 -0.990266110404731 6.58107345321622e-13 miRNAWalker2_validate;MirTarget -0.629694080358735 1.12646103848718e-32 NA NA NA hsa-miR-107 LATS1 0.678998026350662 2.56224148930538e-16 -0.990266110404731 6.58107345321622e-13 MirTarget;miRanda;miRNATAP -0.437594246567329 7.33566816019842e-15 NA NA NA hsa-miR-15a-5p LATS1 0.812445324157528 4.50263417099822e-20 -0.990266110404731 6.58107345321622e-13 MirTarget;miRNATAP -0.573159842937478 6.51444969019854e-29 NA NA NA hsa-miR-15b-5p LATS1 0.788659356634696 1.13678211092534e-11 -0.990266110404731 6.58107345321622e-13 MirTarget;miRNATAP -0.1578733258912 0.000105971395381548 NA NA NA hsa-miR-181a-5p LATS1 0.635863607630183 6.72486918157744e-11 -0.990266110404731 6.58107345321622e-13 MirTarget;miRNATAP -0.340775150880749 1.58719637942256e-12 NA NA NA hsa-miR-181b-5p LATS1 1.22749257795094 1.21998198830919e-27 -0.990266110404731 6.58107345321622e-13 MirTarget;miRNATAP -0.324960445484708 1.09483799491472e-15 NA NA NA hsa-miR-181c-5p LATS1 0.574847839298605 4.51287502066478e-07 -0.990266110404731 6.58107345321622e-13 MirTarget;miRNATAP -0.216492256274596 2.01231029863382e-07 NA NA NA hsa-miR-181d-5p LATS1 0.782618466877349 1.2821116358212e-09 -0.990266110404731 6.58107345321622e-13 MirTarget -0.202147794679768 3.31208189430586e-08 NA NA NA hsa-miR-194-5p LATS1 0.467781870340114 1.0386810618625e-07 -0.990266110404731 6.58107345321622e-13 miRNATAP -0.166602825917208 0.00219039330169264 NA NA NA hsa-miR-19b-1-5p LATS1 0.647704962003062 3.07687667945597e-07 -0.990266110404731 6.58107345321622e-13 MirTarget -0.147792640580873 8.47987127141072e-05 NA NA NA hsa-miR-200c-3p LATS1 2.07038651806183 6.84613386286599e-51 -0.990266110404731 6.58107345321622e-13 miRNATAP -0.129530797506882 6.79149629055103e-05 NA NA NA hsa-miR-21-5p LATS1 2.32007501846389 3.08394781855554e-137 -0.990266110404731 6.58107345321622e-13 miRNAWalker2_validate -0.341435277796525 1.60822085351667e-15 25769949 miR 21 modulates resistance of HR HPV positive cervical cancer cells to radiation through targeting LATS1; By using dual luciferase assay we verified a binding site between miR-21 and 3'-UTR of large tumor suppressor kinase 1 LATS1; Through direct binding miR-21 can regulate LATS1 expression in cervical cancer cells; LATS1 overexpression can reverse miR-21 induced higher colony formation rate and also reduced miR-21 induced S phase accumulation and G2/M phase block reduction under radiation treatment drug resistance cervical and endocervical cancer hsa-miR-25-3p LATS1 -0.00546790775985073 0.944061771389468 -0.990266110404731 6.58107345321622e-13 miRNATAP -0.328456422320455 1.0177954775691e-07 NA NA NA hsa-miR-3065-3p LATS1 1.62787885002468 6.81477830005026e-19 -0.990266110404731 6.58107345321622e-13 MirTarget;miRNATAP -0.114018751693539 7.43505545751175e-06 NA NA NA hsa-miR-32-5p LATS1 1.38676603945192 2.29428299685976e-34 -0.990266110404731 6.58107345321622e-13 miRNATAP -0.236150954921809 4.46209724514235e-09 NA NA NA hsa-miR-320a LATS1 -0.287921276129346 0.00141693637596294 -0.990266110404731 6.58107345321622e-13 miRanda;miRNATAP -0.17151767497783 0.00127867127578605 NA NA NA hsa-miR-361-5p LATS1 -0.0996867547900457 0.095428250126326 -0.990266110404731 6.58107345321622e-13 mirMAP -0.704775579585814 1.08400808725733e-18 NA NA NA hsa-miR-374a-5p LATS1 -0.239709888246804 0.00309819667153627 -0.990266110404731 6.58107345321622e-13 mirMAP -0.235455539279346 7.25336889477625e-05 NA NA NA hsa-miR-429 LATS1 2.84108892259147 3.88520896426515e-64 -0.990266110404731 6.58107345321622e-13 PITA;miRanda;miRNATAP -0.16445910331278 3.57904693957067e-10 NA NA NA hsa-miR-590-3p LATS1 1.27438512890514 1.03164723481469e-23 -0.990266110404731 6.58107345321622e-13 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.132479784208516 0.000552705043282948 NA NA NA hsa-miR-103a-3p LATS2 0.610673390034345 1.63113920514646e-12 -1.07930752603412 1.77477579396165e-33 miRNATAP -0.358046802972383 1.1783193928484e-23 27602163 Furthermore miR-103 repressed large tumor suppressor kinase 2 LATS2 expression by directly binding to the LATS2-3'-untranslated region and an inverse correlation was identified between the expression of miR-103 and LATS2 messenger RNA in primary CRC tissues; In summary miR-103 performs a critical role in the promotion of the invasive and metastatic capacities of CRC possibly by directly targeting LATS2 colorectal cancer hsa-miR-107 LATS2 0.678998026350662 2.56224148930538e-16 -1.07930752603412 1.77477579396165e-33 PITA;miRanda;miRNATAP -0.272467620483835 4.40674398745622e-13 NA NA NA hsa-miR-15a-5p LATS2 0.812445324157528 4.50263417099822e-20 -1.07930752603412 1.77477579396165e-33 miRNATAP -0.321597435872587 1.68615522284753e-20 NA NA NA hsa-miR-15b-5p LATS2 0.788659356634696 1.13678211092534e-11 -1.07930752603412 1.77477579396165e-33 miRNATAP -0.140565602765784 2.08465837383112e-07 NA NA NA hsa-miR-200b-3p LATS2 2.11744072703209 1.66710572104191e-43 -1.07930752603412 1.77477579396165e-33 TargetScan -0.242433743681395 1.08648777794347e-37 NA NA NA hsa-miR-200c-3p LATS2 2.07038651806183 6.84613386286599e-51 -1.07930752603412 1.77477579396165e-33 miRNATAP -0.293619037542608 2.39755570299602e-46 NA NA NA hsa-miR-25-3p LATS2 -0.00546790775985073 0.944061771389468 -1.07930752603412 1.77477579396165e-33 miRNATAP -0.132429570644068 0.00137412723209594 25179841 MiR 25 promotes ovarian cancer proliferation and motility by targeting LATS2; Large tumor suppressor 2 LATS2 a tumor suppressor was confirmed to be a direct target of miR-25 in OC cells; Moreover restoration of LATS2 significantly attenuated the oncogenic effects of miR-25 motility ovarian cancer hsa-miR-30d-5p LATS2 -0.247082219011045 0.00406717930063148 -1.07930752603412 1.77477579396165e-33 miRNATAP -0.113965345251451 0.0022712884200573 NA NA NA hsa-miR-32-5p LATS2 1.38676603945192 2.29428299685976e-34 -1.07930752603412 1.77477579396165e-33 miRNATAP -0.215767294711211 5.15797901117458e-16 NA NA NA hsa-miR-342-3p LATS2 1.21944481975657 6.81914373001202e-19 -1.07930752603412 1.77477579396165e-33 PITA;miRanda -0.207208487150241 1.29131766504045e-20 NA NA NA hsa-miR-429 LATS2 2.84108892259147 3.88520896426515e-64 -1.07930752603412 1.77477579396165e-33 PITA;miRanda;miRNATAP -0.210085665924318 2.16730453894399e-35 NA NA NA hsa-miR-590-3p LATS2 1.27438512890514 1.03164723481469e-23 -1.07930752603412 1.77477579396165e-33 PITA;miRanda -0.154698530307227 1.12860396390346e-09 NA NA NA hsa-miR-93-5p LATS2 1.01788600209314 1.24312921618126e-21 -1.07930752603412 1.77477579396165e-33 miRNAWalker2_validate -0.281109540672598 7.83192633245739e-23 NA NA NA hsa-miR-96-5p LATS2 3.24596558166606 1.92296159041707e-98 -1.07930752603412 1.77477579396165e-33 miRNATAP -0.248313256795386 4.07672171830279e-46 NA NA NA hsa-miR-326 LEF1 -1.54449030848141 1.04703417845594e-17 2.04129621040026 7.44253629249046e-48 miRanda -0.135291856721102 1.0203567859312e-06 NA NA NA hsa-miR-335-3p LEF1 -1.88448538773649 2.09538234398335e-32 2.04129621040026 7.44253629249046e-48 mirMAP -0.25656991808437 2.69608203703196e-17 NA NA NA hsa-miR-125b-2-3p LIMD1 -1.92374904783012 2.30779527653582e-38 0.312071976111651 1.36939590396432e-06 mirMAP -0.115196393093836 2.23484648415891e-16 NA NA NA hsa-miR-143-3p LIMD1 -1.23248181631499 4.74160976678504e-28 0.312071976111651 1.36939590396432e-06 mirMAP -0.104285528664699 4.56578294005925e-08 NA NA NA hsa-miR-146b-5p LIMD1 0.631041661167954 6.20366593452965e-08 0.312071976111651 1.36939590396432e-06 mirMAP -0.105225115825489 2.35388524578204e-08 NA NA NA hsa-miR-199b-5p LIMD1 -1.37022396448377 3.25758057539223e-26 0.312071976111651 1.36939590396432e-06 miRanda -0.103323270966725 4.0191643452796e-10 NA NA NA hsa-miR-2355-5p LIMD1 -0.221733044425126 0.0231054202524677 0.312071976111651 1.36939590396432e-06 mirMAP -0.114220769445175 5.20295655507422e-07 NA NA NA hsa-miR-362-5p LIMD1 -0.248676340901797 0.0726089851456282 0.312071976111651 1.36939590396432e-06 mirMAP -0.108419141867299 8.84122353291351e-12 NA NA NA hsa-miR-500a-3p LIMD1 0.139523673241448 0.185528510741158 0.312071976111651 1.36939590396432e-06 mirMAP -0.106323442116403 4.54554804866876e-07 NA NA NA hsa-miR-660-5p LIMD1 0.406910761707485 0.000156175371762464 0.312071976111651 1.36939590396432e-06 mirMAP -0.150217086879996 1.71582466177462e-13 NA NA NA hsa-miR-146b-3p LLGL2 -0.260891807886908 0.0211838235241739 2.09596517714534 6.31091585684175e-69 miRNATAP -0.114760122328955 0.00370367599028687 NA NA NA hsa-miR-199a-3p LLGL2 -0.174830922802531 0.138748242352612 2.09596517714534 6.31091585684175e-69 PITA;miRNATAP -0.274337119781856 2.2740884400331e-13 NA NA NA hsa-miR-199b-3p LLGL2 -0.173412359075504 0.143232985227463 2.09596517714534 6.31091585684175e-69 PITA;miRNATAP -0.273619256714983 2.20653286066066e-13 NA NA NA hsa-miR-335-5p LLGL2 -2.61355235628987 2.6462884165886e-51 2.09596517714534 6.31091585684175e-69 miRNAWalker2_validate -0.256077448580076 8.45877704963449e-28 NA NA NA hsa-miR-130b-3p MPP5 1.38122163823846 1.00932179737836e-26 -0.461905356415691 2.1822279898673e-09 miRNAWalker2_validate -0.135328543707108 1.12553575854657e-11 NA NA NA hsa-miR-140-3p MPP5 -1.25844395244141 5.29222651039892e-33 -0.461905356415691 2.1822279898673e-09 PITA -0.132687681070432 4.67376513324837e-08 NA NA NA hsa-miR-155-5p MPP5 1.09766314984151 4.55650930885814e-15 -0.461905356415691 2.1822279898673e-09 miRNAWalker2_validate;MirTarget -0.134988324751498 2.95146083302425e-13 NA NA NA hsa-miR-181a-5p MPP5 0.635863607630183 6.72486918157744e-11 -0.461905356415691 2.1822279898673e-09 MirTarget -0.181669874966801 1.43580445258531e-11 NA NA NA hsa-miR-181b-5p MPP5 1.22749257795094 1.21998198830919e-27 -0.461905356415691 2.1822279898673e-09 MirTarget -0.1754645655224 8.46046667722238e-15 NA NA NA hsa-miR-181c-5p MPP5 0.574847839298605 4.51287502066478e-07 -0.461905356415691 2.1822279898673e-09 MirTarget -0.112758719841691 1.20193442688512e-06 NA NA NA hsa-miR-181d-5p MPP5 0.782618466877349 1.2821116358212e-09 -0.461905356415691 2.1822279898673e-09 MirTarget -0.103158730378828 4.34678789386237e-07 NA NA NA hsa-miR-21-5p MPP5 2.32007501846389 3.08394781855554e-137 -0.461905356415691 2.1822279898673e-09 miRNAWalker2_validate -0.237239157137834 9.36639981799512e-24 NA NA NA hsa-miR-542-3p MPP5 0.568822103820889 8.5699075257651e-07 -0.461905356415691 2.1822279898673e-09 miRanda -0.125917800375743 3.58585562782832e-08 NA NA NA hsa-miR-21-5p MYC 2.32007501846389 3.08394781855554e-137 -1.13124656428776 3.22608205108151e-16 miRNAWalker2_validate -0.270190862069706 5.76701615920235e-10 22072622 In contrast the levels of β-catenin TCF/LEF activity and the expression of c-Myc Cyclin-D which are increased in CSCs are also augmented in miR-21 overexpressing colon cancer cells accompanied by an increased sphere forming ability in vitro and tumor formation in SCID mice colon cancer hsa-miR-34a-5p MYC 0.129201805242403 0.133261654068224 -1.13124656428776 3.22608205108151e-16 miRNAWalker2_validate;miRTarBase -0.216308870548993 0.000129276161670072 25572695;25686834;21460242;22159222;23640973;22830357;22235332 The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;miR 34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c Myc pathway;Myc mediated repression of microRNA 34a promotes high grade transformation of B cell lymphoma by dysregulation of FoxP1;MicroRNA 34a suppresses malignant transformation by targeting c Myc transcriptional complexes in human renal cell carcinoma; We investigated the functional effects of microRNA-34a miR-34a on c-Myc transcriptional complexes in renal cell carcinoma; miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region which was revealed by luciferase reporter assays; Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription indicating a novel role of miR-34a in the regulation of transcription by c-Myc;Among them miR-34a was also associated with poor prognosis in 2 independent series of leukemic and nodal MCL and in cooperation with high expression of the MYC oncogene;We report that miR-34a did not inhibit cell proliferation notwithstanding a marked down-regulation of c-MYC;MicroRNA 34a modulates c Myc transcriptional complexes to suppress malignancy in human prostate cancer cells; We studied the functional effects of miR-34a on c-Myc transcriptional complexes in PC-3 prostate cancer cells; miR-34a downregulated expression of c-Myc oncogene by targeting its 3' UTR as shown by luciferase reporter assays; This is the first report to document that miR-34a suppresses assembly and function of the c-Myc-Skp2-Miz1 complex that activates RhoA and the c-Myc-pTEFB complex that elongates transcription of various genes suggesting a novel role of miR-34a in the regulation of transcription by c-Myc complex ;;;malignant trasformation;worse prognosis;; bladder cancer;liver cancer;B cell lymphoma;kidney renal cell cancer;lymphoma;lymphoma;prostate cancer hsa-miR-429 MYC 2.84108892259147 3.88520896426515e-64 -1.13124656428776 3.22608205108151e-16 miRNAWalker2_validate -0.108453248703558 4.76591679996824e-05 21684154;24633485 miR 429 modulates the expression of c myc in human gastric carcinoma cells; SGC-7901 gastric cancer cells were transfected with miR-429 mimics and endogenous c-myc expression was detected by western blots; We performed functional assays using the 3'UTR of the c-myc gene as a miR-429 target in a luciferase reporter assay system; miR-429 significantly downregulated endogenous c-myc expression in SGC-7901 cells; Action of miR/429 on c-myc 3'UTR was confirmed; c-myc is an important miR-429 target gene;It is known that miR-429 is down-regulated and functions as a tumor suppressor by targeting c-myc and PLGG1 in gastric and breast cancer ; gastric cancer;sarcoma hsa-let-7a-5p NKD1 -0.210286642041636 0.0072546234707717 0.687327063082442 3.30390073218128e-06 TargetScan -0.285119479952564 1.26690218381995e-05 NA NA NA hsa-miR-125a-5p NKD1 -0.635694700253268 3.6703235721638e-11 0.687327063082442 3.30390073218128e-06 miRanda -0.278399457854937 1.03346527875826e-07 NA NA NA hsa-miR-361-5p NKD1 -0.0996867547900457 0.095428250126326 0.687327063082442 3.30390073218128e-06 miRanda -0.242196570817123 0.00520088014824435 NA NA NA hsa-miR-146b-3p PARD6A -0.260891807886908 0.0211838235241739 0.829151093908741 3.68643922472876e-13 miRNATAP -0.205586051125295 3.64034482842406e-09 NA NA NA hsa-miR-409-3p PARD6A -0.484157606580319 4.02222513573154e-05 0.829151093908741 3.68643922472876e-13 miRNATAP -0.209431886650606 3.28681425203323e-10 NA NA NA hsa-let-7c-5p PARD6B -1.9415540533505 9.55250745007793e-48 1.70997497031339 2.55366919190462e-20 MirTarget -0.418221381322077 9.76899190880739e-21 NA NA NA hsa-let-7i-5p PARD6B -0.333419326258177 3.56960810786801e-08 1.70997497031339 2.55366919190462e-20 MirTarget;miRNATAP -1.05571567883262 1.39099222134469e-23 NA NA NA hsa-miR-140-5p PARD6B -0.755971041589807 9.68060922934542e-14 1.70997497031339 2.55366919190462e-20 miRanda -0.523507722714555 3.66346033089813e-17 NA NA NA hsa-miR-143-5p PARD6B -1.08813426434718 6.46387834906802e-10 1.70997497031339 2.55366919190462e-20 MirTarget -0.137922215087697 0.000154934585089431 NA NA NA hsa-miR-17-5p PARD6B 0.599531757298529 1.07318660415906e-05 1.70997497031339 2.55366919190462e-20 MirTarget;TargetScan;miRNATAP -0.225841514810454 1.85017811733567e-06 NA NA NA hsa-miR-18a-5p PARD6B 0.969066793715868 1.69069796425892e-08 1.70997497031339 2.55366919190462e-20 miRNAWalker2_validate;MirTarget -0.284811022335125 1.39901909644042e-14 NA NA NA hsa-miR-196b-5p PARD6B -0.302231359742807 0.0833893928085868 1.70997497031339 2.55366919190462e-20 MirTarget -0.15194491665842 4.28733186799145e-05 NA NA NA hsa-miR-20a-3p PARD6B -0.218902047543766 0.179868363625547 1.70997497031339 2.55366919190462e-20 mirMAP -0.103435741201242 0.00970470277410766 NA NA NA hsa-miR-20a-5p PARD6B 0.44979911120222 0.000602386964327228 1.70997497031339 2.55366919190462e-20 MirTarget;miRNATAP -0.285372625571755 6.42193271488439e-09 NA NA NA hsa-miR-223-3p PARD6B -0.966406159689943 7.90612601654887e-12 1.70997497031339 2.55366919190462e-20 MirTarget -0.436848323089214 6.10174627335383e-23 NA NA NA hsa-miR-27a-3p PARD6B 0.388496361379095 1.42373532086331e-05 1.70997497031339 2.55366919190462e-20 MirTarget;miRNATAP -0.436450895937542 1.43683185193109e-09 NA NA NA hsa-miR-27b-3p PARD6B -0.0796803270437447 0.410503155574393 1.70997497031339 2.55366919190462e-20 MirTarget;miRNATAP -0.38567304817476 8.7246322870566e-09 NA NA NA hsa-miR-335-3p PARD6B -1.88448538773649 2.09538234398335e-32 1.70997497031339 2.55366919190462e-20 mirMAP -0.189630090245081 1.24886161971586e-06 NA NA NA hsa-miR-335-5p PARD6B -2.61355235628987 2.6462884165886e-51 1.70997497031339 2.55366919190462e-20 miRNAWalker2_validate -0.129495953426302 0.000232202714037223 NA NA NA hsa-miR-369-3p PARD6B 0.0880848299432269 0.48519534195924 1.70997497031339 2.55366919190462e-20 miRNATAP -0.318010599926403 6.43125889126386e-10 NA NA NA hsa-miR-374a-5p PARD6B -0.239709888246804 0.00309819667153627 1.70997497031339 2.55366919190462e-20 MirTarget;mirMAP -0.607394011196526 2.24880475462993e-14 NA NA NA hsa-miR-374b-5p PARD6B -0.466781429946153 1.17238311619116e-08 1.70997497031339 2.55366919190462e-20 miRNAWalker2_validate;MirTarget;mirMAP -0.610311576130569 5.69936550958004e-15 NA NA NA hsa-miR-381-3p PARD6B -1.28028930293369 1.61402949866141e-23 1.70997497031339 2.55366919190462e-20 MirTarget -0.433539522998549 3.38479855788693e-19 NA NA NA hsa-miR-409-3p PARD6B -0.484157606580319 4.02222513573154e-05 1.70997497031339 2.55366919190462e-20 PITA -0.290023335465978 1.20469429582271e-07 NA NA NA hsa-miR-411-5p PARD6B -0.975911498088906 3.12547465315205e-11 1.70997497031339 2.55366919190462e-20 MirTarget -0.263691363100028 1.87288756638124e-09 NA NA NA hsa-miR-455-5p PARD6B 0.284641224662773 0.0357572339594277 1.70997497031339 2.55366919190462e-20 miRanda -0.350607899684853 1.34991683014832e-13 NA NA NA hsa-miR-576-5p PARD6B 0.0649387707567879 0.588791966096287 1.70997497031339 2.55366919190462e-20 mirMAP -0.188215154429256 0.000518206282645936 NA NA NA hsa-miR-582-5p PARD6B 0.201134299470983 0.149482495292227 1.70997497031339 2.55366919190462e-20 MirTarget;PITA;miRNATAP -0.303512539901501 8.05604636501297e-11 NA NA NA hsa-miR-589-3p PARD6B 0.0263457630961427 0.866577983997705 1.70997497031339 2.55366919190462e-20 MirTarget -0.150118514998413 0.0004012616611031 NA NA NA hsa-miR-92a-3p PARD6B -0.342420481092807 0.000732275969501111 1.70997497031339 2.55366919190462e-20 mirMAP -0.427868788224213 1.63951165861329e-11 NA NA NA hsa-miR-454-3p PARD6G 1.28177672191095 6.84024979484587e-21 -0.595529281136792 1.51526154438781e-14 mirMAP -0.110443607069819 9.5197241072227e-09 NA NA NA hsa-miR-125a-5p PPP1CA -0.635694700253268 3.6703235721638e-11 1.18161050714226 2.46562006067542e-52 miRanda;miRNATAP -0.200474531146665 4.72542550396351e-12 NA NA NA hsa-miR-125b-5p PPP1CA -1.94393269763542 2.78180543229264e-58 1.18161050714226 2.46562006067542e-52 miRTarBase -0.295075066569947 3.20807641601885e-46 25240408 MiR 125b promotes cell migration and invasion by targeting PPP1CA Rb signal pathways in gastric cancer resulting in a poor prognosis; MiR-125b was upregulated in gastric cancer tissues and cell lines and significantly promoted cellular proliferation migration and invasion by downregulating the expression of PPP1CA and upregulating Rb phosphorylation; MiR-125b functions as an oncogene by targeting downregulated PPP1CA and upregulated Rb phosphorylation in gastric cancer worse prognosis;cell migration gastric cancer hsa-miR-215-5p PPP1CA -1.35643065897947 2.3180023440257e-20 1.18161050714226 2.46562006067542e-52 miRNAWalker2_validate -0.103406298934678 3.96280832536328e-08 NA NA NA hsa-miR-26a-5p PPP1CC -0.481180084102235 1.82368246174758e-10 -0.0705148909144473 0.1349116326376 miRNAWalker2_validate -0.119039901705772 1.79899770528746e-08 NA NA NA hsa-miR-17-3p PPP2CA 0.721439431208839 7.95900548819742e-10 0.355964216272682 1.3164574185057e-12 MirTarget -0.133330530645377 1.5958296816568e-20 NA NA NA hsa-miR-425-5p PPP2CB 0.719898949241718 6.01079610190374e-08 -0.508468028837195 3.29413468049735e-15 miRNAWalker2_validate -0.1434305833926 3.027811361313e-18 NA NA NA hsa-miR-590-3p PPP2CB 1.27438512890514 1.03164723481469e-23 -0.508468028837195 3.29413468049735e-15 miRanda -0.10511834935696 4.0251015210593e-09 NA NA NA hsa-miR-128-3p PPP2R1B 0.90296715955238 9.925204823863e-23 -1.24069690315388 3.45729939213988e-47 MirTarget -0.109583188561297 0.000963818534703709 NA NA NA hsa-miR-146b-5p PPP2R1B 0.631041661167954 6.20366593452965e-08 -1.24069690315388 3.45729939213988e-47 miRanda -0.141184532696467 1.00140046078863e-07 NA NA NA hsa-miR-15a-5p PPP2R1B 0.812445324157528 4.50263417099822e-20 -1.24069690315388 3.45729939213988e-47 MirTarget -0.195736754254626 1.30304715741401e-08 NA NA NA hsa-miR-200b-3p PPP2R1B 2.11744072703209 1.66710572104191e-43 -1.24069690315388 3.45729939213988e-47 MirTarget -0.190114683335312 5.20726875191601e-24 NA NA NA hsa-miR-200c-3p PPP2R1B 2.07038651806183 6.84613386286599e-51 -1.24069690315388 3.45729939213988e-47 MirTarget -0.226923946553815 2.68646974148231e-28 21248297 Western blotting showed that knockdown of miR-200c expression was associated with increased expression of PPP2R1B a subunit of protein phosphatase 2A which resulted in reduced expression of phospho-Akt esophageal cancer hsa-miR-30d-3p PPP2R1B 0.264544633563642 0.00755023189129747 -1.24069690315388 3.45729939213988e-47 mirMAP -0.157184793756038 6.17261426855798e-07 NA NA NA hsa-miR-429 PPP2R1B 2.84108892259147 3.88520896426515e-64 -1.24069690315388 3.45729939213988e-47 MirTarget;miRanda;miRNATAP -0.148415458438853 1.78268855237664e-18 NA NA NA hsa-let-7i-5p PPP2R2A -0.333419326258177 3.56960810786801e-08 -0.167330560503955 0.00931403270504818 miRNATAP -0.107110666603503 0.00353562731274897 NA NA NA hsa-miR-106b-5p PPP2R2A 1.22477789913175 2.31787213143326e-32 -0.167330560503955 0.00931403270504818 MirTarget;miRNATAP -0.11513710270418 1.67830991715771e-08 NA NA NA hsa-miR-374a-5p PPP2R2A -0.239709888246804 0.00309819667153627 -0.167330560503955 0.00931403270504818 mirMAP -0.108346705337341 7.22514521796377e-05 NA NA NA hsa-miR-107 PPP2R2B 0.678998026350662 2.56224148930538e-16 -1.93953123840583 5.78989293907757e-30 miRanda -0.382818751276931 1.02239949522717e-07 NA NA NA hsa-miR-141-3p PPP2R2B 2.99777540204168 1.26370498493024e-78 -1.93953123840583 5.78989293907757e-30 TargetScan -0.315881073340513 5.36482191004776e-21 NA NA NA hsa-miR-7-1-3p PPP2R2B 0.686579567507582 1.20731554448806e-07 -1.93953123840583 5.78989293907757e-30 mirMAP -0.161881570908929 0.000489281404028886 NA NA NA hsa-miR-181a-2-3p PPP2R2C -0.0718643470098321 0.422077954889554 2.25419279038223 3.53879659770262e-10 MirTarget -0.44823553635027 0.00136468286381967 NA NA NA hsa-miR-218-5p PPP2R2C -1.02621788318234 2.9221925445771e-23 2.25419279038223 3.53879659770262e-10 miRNATAP -0.43489406545735 0.000214380392578878 NA NA NA hsa-miR-374b-5p PPP2R2C -0.466781429946153 1.17238311619116e-08 2.25419279038223 3.53879659770262e-10 miRNATAP -0.466306325492385 0.00215151258507057 NA NA NA hsa-miR-500a-3p PPP2R2C 0.139523673241448 0.185528510741158 2.25419279038223 3.53879659770262e-10 MirTarget -0.359889661556384 0.00241165449343688 NA NA NA hsa-miR-140-3p PRKCI -1.25844395244141 5.29222651039892e-33 0.176736645851093 0.00973207089633128 PITA -0.168816139602313 1.2446500581131e-15 NA NA NA hsa-miR-361-5p PRKCI -0.0996867547900457 0.095428250126326 0.176736645851093 0.00973207089633128 miRanda -0.190915906472787 1.48903693880208e-06 NA NA NA hsa-miR-125a-5p PRKCZ -0.635694700253268 3.6703235721638e-11 1.51865275319949 8.17912638952476e-44 miRanda -0.124764785209615 0.00229214022910686 NA NA NA hsa-miR-152-3p PRKCZ -0.26603867075042 0.0063861560676033 1.51865275319949 8.17912638952476e-44 MirTarget -0.228144890446044 1.70083864286456e-08 NA NA NA hsa-miR-491-5p PRKCZ -1.04307210952796 1.14586501470398e-15 1.51865275319949 8.17912638952476e-44 miRanda -0.175272674608489 4.54466360317094e-09 NA NA NA hsa-miR-106b-5p RASSF6 1.22477789913175 2.31787213143326e-32 -1.62653509090766 2.29713406852116e-12 mirMAP -0.54031663940939 3.19387114966144e-13 NA NA NA hsa-miR-125a-3p RASSF6 -0.176412960953959 0.10108079286419 -1.62653509090766 2.29713406852116e-12 MirTarget;miRanda -0.225478169395997 0.00274468449763165 NA NA NA hsa-miR-128-3p RASSF6 0.90296715955238 9.925204823863e-23 -1.62653509090766 2.29713406852116e-12 miRNAWalker2_validate -0.552671344742067 7.18949151744401e-11 NA NA NA hsa-miR-130b-3p RASSF6 1.38122163823846 1.00932179737836e-26 -1.62653509090766 2.29713406852116e-12 mirMAP -0.473186545386172 2.82598578160578e-15 NA NA NA hsa-miR-130b-5p RASSF6 1.0573161199584 2.55177349228739e-12 -1.62653509090766 2.29713406852116e-12 mirMAP -0.248702778801427 2.10605972422355e-06 NA NA NA hsa-miR-148b-3p RASSF6 1.0552576751879 1.6679285705231e-29 -1.62653509090766 2.29713406852116e-12 miRNAWalker2_validate -0.273801682466905 0.00102993695517431 NA NA NA hsa-miR-16-1-3p RASSF6 1.30142784811196 2.53343713753744e-29 -1.62653509090766 2.29713406852116e-12 mirMAP -0.517801510406929 1.85212525501328e-13 NA NA NA hsa-miR-16-2-3p RASSF6 0.286355254959005 0.0256946046884474 -1.62653509090766 2.29713406852116e-12 mirMAP -0.359047127286117 1.07649760848149e-08 NA NA NA hsa-miR-17-3p RASSF6 0.721439431208839 7.95900548819742e-10 -1.62653509090766 2.29713406852116e-12 MirTarget -0.39951244480068 3.37233870261043e-09 NA NA NA hsa-miR-17-5p RASSF6 0.599531757298529 1.07318660415906e-05 -1.62653509090766 2.29713406852116e-12 mirMAP -0.392847524258319 1.60348200940056e-11 NA NA NA hsa-miR-181a-5p RASSF6 0.635863607630183 6.72486918157744e-11 -1.62653509090766 2.29713406852116e-12 miRNAWalker2_validate -0.292164293990262 0.000367993394580001 NA NA NA hsa-miR-20a-5p RASSF6 0.44979911120222 0.000602386964327228 -1.62653509090766 2.29713406852116e-12 mirMAP -0.359206082056693 3.68345017973067e-09 NA NA NA hsa-miR-25-3p RASSF6 -0.00546790775985073 0.944061771389468 -1.62653509090766 2.29713406852116e-12 mirMAP -0.376713594037621 0.000302753401162291 NA NA NA hsa-miR-301a-3p RASSF6 1.32170168375632 2.12280368957514e-15 -1.62653509090766 2.29713406852116e-12 mirMAP -0.374796374774087 1.73248853452329e-15 NA NA NA hsa-miR-32-5p RASSF6 1.38676603945192 2.29428299685976e-34 -1.62653509090766 2.29713406852116e-12 mirMAP -0.282240359060075 3.37901028516083e-05 NA NA NA hsa-miR-338-3p RASSF6 0.0799903526884966 0.575137668326679 -1.62653509090766 2.29713406852116e-12 miRanda -0.228601790910041 5.07414988357332e-05 NA NA NA hsa-miR-339-5p RASSF6 -0.211548290465418 0.0685885445822389 -1.62653509090766 2.29713406852116e-12 miRanda -0.287205444190867 3.45385914149767e-05 NA NA NA hsa-miR-361-5p RASSF6 -0.0996867547900457 0.095428250126326 -1.62653509090766 2.29713406852116e-12 miRanda -0.702605829907692 2.57671096715744e-07 NA NA NA hsa-miR-454-3p RASSF6 1.28177672191095 6.84024979484587e-21 -1.62653509090766 2.29713406852116e-12 mirMAP -0.381337445572115 2.8725359140682e-11 NA NA NA hsa-miR-532-5p RASSF6 0.0386976222860582 0.682018574136515 -1.62653509090766 2.29713406852116e-12 MirTarget -0.423596923609313 7.07375582818919e-07 NA NA NA hsa-miR-590-3p RASSF6 1.27438512890514 1.03164723481469e-23 -1.62653509090766 2.29713406852116e-12 miRanda;mirMAP;miRNATAP -0.272621931946504 2.31448442857932e-05 NA NA NA hsa-miR-590-5p RASSF6 0.746515607868274 8.51300479640125e-09 -1.62653509090766 2.29713406852116e-12 miRanda;miRNATAP -0.231381173837895 0.000173689537296357 NA NA NA hsa-miR-92a-3p RASSF6 -0.342420481092807 0.000732275969501111 -1.62653509090766 2.29713406852116e-12 mirMAP -0.300428135755816 0.00015631029162694 NA NA NA hsa-miR-92b-3p RASSF6 1.30248132773644 9.42428674470985e-25 -1.62653509090766 2.29713406852116e-12 mirMAP -0.258629279988239 2.69055495688004e-05 NA NA NA hsa-miR-93-5p RASSF6 1.01788600209314 1.24312921618126e-21 -1.62653509090766 2.29713406852116e-12 mirMAP -0.622082318851599 9.97131035907041e-18 NA NA NA hsa-miR-103a-3p SAV1 0.610673390034345 1.63113920514646e-12 -1.09676283661383 2.02387569651186e-52 miRNAWalker2_validate -0.312223088165798 1.6911467577448e-26 NA NA NA hsa-miR-107 SAV1 0.678998026350662 2.56224148930538e-16 -1.09676283661383 2.02387569651186e-52 PITA;miRanda;miRNATAP -0.281823056891181 4.36093447365523e-20 NA NA NA hsa-miR-193b-3p SCRIB -0.0550374855074773 0.65382485898551 1.11581172578847 2.37743359459082e-26 miRNAWalker2_validate -0.108162842967317 0.000361790318918099 NA NA NA hsa-miR-30a-5p SERPINE1 -0.392489994825279 0.00954894667761676 1.12049888044954 7.60138805308414e-13 miRNATAP -0.145922595645178 4.52059974009477e-05 NA NA NA hsa-miR-30b-5p SERPINE1 -0.46540603860146 2.4709940429591e-05 1.12049888044954 7.60138805308414e-13 MirTarget -0.308253693084862 2.51129673053519e-10 25170877 miR-30b may function as a novel tumor suppressor gene in gastric cancer by targeting PAI-1 and regulating the apoptosis of cancer cells gastric cancer hsa-miR-30c-5p SERPINE1 -0.393222674580066 8.06961465717306e-05 1.12049888044954 7.60138805308414e-13 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.300227762852185 2.96907430143248e-08 NA NA NA hsa-miR-30d-5p SERPINE1 -0.247082219011045 0.00406717930063148 1.12049888044954 7.60138805308414e-13 miRNATAP -0.37317010013897 3.19444120977288e-09 NA NA NA hsa-miR-181a-5p SMAD2 0.635863607630183 6.72486918157744e-11 -0.328226721195286 1.10147955577876e-10 mirMAP -0.115122429788219 8.47012412856965e-11 24394555 Here we show that miR-181a promotes TGF-β-mediated epithelial-to-mesenchymal transition via repression of its functional target Smad7 miR-181a and phosphorylated Smad2 are enriched in recurrent compared with matched-primary ovarian tumours and their expression is associated with shorter time to recurrence and poor outcome in patients with EOC recurrence ovarian cancer hsa-miR-181b-5p SMAD2 1.22749257795094 1.21998198830919e-27 -0.328226721195286 1.10147955577876e-10 mirMAP -0.112879931507918 3.62142519922135e-14 NA NA NA hsa-miR-340-5p SMAD2 1.0857159627596 4.94471062546756e-24 -0.328226721195286 1.10147955577876e-10 MirTarget -0.145840275032375 8.51041709723394e-21 NA NA NA hsa-miR-361-3p SMAD2 -0.0370446538644886 0.624902392829872 -0.328226721195286 1.10147955577876e-10 miRNATAP -0.128521633108847 3.38235989722682e-08 22675530 Functional analyses showed that Smad2 and TGFß1 are not dysregulated by miR-361-3p and miR-625* in the lung cell line A549 respectively lung cancer hsa-miR-361-5p SMAD2 -0.0996867547900457 0.095428250126326 -0.328226721195286 1.10147955577876e-10 MirTarget -0.168440579811925 1.40285064429544e-08 NA NA NA hsa-miR-542-3p SMAD2 0.568822103820889 8.5699075257651e-07 -0.328226721195286 1.10147955577876e-10 PITA -0.104251622984305 3.31535587210055e-12 NA NA NA hsa-miR-155-5p SMAD3 1.09766314984151 4.55650930885814e-15 -0.590930154862025 2.18041656438712e-13 miRNAWalker2_validate -0.161248941325708 6.88088611744894e-17 27626488 Here we demonstrated that TGF-β1 elevated the expression of miR-155 in colorectal cancer cells through SMAD3 and SMAD4 colorectal cancer hsa-miR-15a-5p SMAD3 0.812445324157528 4.50263417099822e-20 -0.590930154862025 2.18041656438712e-13 MirTarget -0.127238885845652 3.99211956272264e-05 NA NA NA hsa-miR-15b-5p SMAD3 0.788659356634696 1.13678211092534e-11 -0.590930154862025 2.18041656438712e-13 MirTarget -0.103829420518863 1.25324379645245e-05 NA NA NA hsa-miR-17-5p SMAD3 0.599531757298529 1.07318660415906e-05 -0.590930154862025 2.18041656438712e-13 miRNAWalker2_validate -0.144062907194855 1.0396353881575e-12 NA NA NA hsa-miR-185-5p SMAD3 0.482334746589337 3.68475879959415e-09 -0.590930154862025 2.18041656438712e-13 MirTarget -0.139641114876277 4.17733017511663e-05 NA NA NA hsa-miR-18a-5p SMAD3 0.969066793715868 1.69069796425892e-08 -0.590930154862025 2.18041656438712e-13 miRNAWalker2_validate -0.145191271950291 4.28063578565896e-20 23249750 The unexpected effects of miR-18a on CTGF transcription are mediated in part by direct targeting of Smad3 and ensuing weakening of TGFβ signaling glioblastoma hsa-miR-1976 SMAD3 0.289190368864725 0.00167092758216584 -0.590930154862025 2.18041656438712e-13 MirTarget -0.121630671332983 6.52049342337766e-05 NA NA NA hsa-miR-28-5p SMAD3 -0.14267073663385 0.0497619246260571 -0.590930154862025 2.18041656438712e-13 miRNATAP -0.120097254990824 0.00200641803458376 NA NA NA hsa-miR-330-5p SMAD3 0.626063225953928 3.42215028606779e-09 -0.590930154862025 2.18041656438712e-13 miRanda -0.106180722787539 5.07248451793749e-05 NA NA NA hsa-miR-429 SMAD3 2.84108892259147 3.88520896426515e-64 -0.590930154862025 2.18041656438712e-13 miRNATAP -0.102063359852527 2.55000912428033e-11 NA NA NA hsa-miR-590-3p SMAD3 1.27438512890514 1.03164723481469e-23 -0.590930154862025 2.18041656438712e-13 miRanda -0.163099760014662 1.73477690677951e-13 NA NA NA hsa-miR-671-5p SMAD3 1.55248047544015 7.7377784125886e-33 -0.590930154862025 2.18041656438712e-13 MirTarget -0.132445297015047 2.33568059728177e-10 NA NA NA hsa-miR-769-5p SMAD3 0.564871766265874 8.16695101656941e-10 -0.590930154862025 2.18041656438712e-13 miRNATAP -0.121091427985316 6.14487597806327e-05 NA NA NA hsa-miR-106b-5p SMAD4 1.22477789913175 2.31787213143326e-32 -0.624967182926059 1.70248077700642e-24 mirMAP;miRNATAP -0.132593131707842 2.60050027244317e-11 NA NA NA hsa-miR-146b-5p SMAD4 0.631041661167954 6.20366593452965e-08 -0.624967182926059 1.70248077700642e-24 PITA;miRanda;miRNATAP -0.13881112685924 1.84558785229961e-14 21874046;26883911 MicroRNA miR 146b 5p regulates signal transduction of TGF β by repressing SMAD4 in thyroid cancer; A computational search revealed that miR-146b-5p putatively binds to the 3' untranslated region UTR of SMAD4 an important member of the transforming growth factor β TGF-β signaling pathway; Luciferase reporter assay confirmed the direct binding of miR-146b-5p on the SMAD4 3'UTR; Specific inhibition of miR-146b-5p with a locked nucleic acid-modified anti-miR-146b oligonucleotide significantly increased SMAD4 levels in the human papillary carcinoma cell lines TPC-1 and BCPAP; The overexpression of miR-146b-5p in normal rat follicular PCCL3 cells decreased SMAD4 levels and disrupted TGF-β signal transduction;The overexpression of SMAD4 in BCPAP cells a validated target of miR-146b-5p and key protein in the TGF-β signaling pathway inhibited migration similarly to the effects observed with the antagomiR 146b-5p ; thyroid cancer;thyroid cancer hsa-miR-155-5p SMAD4 1.09766314984151 4.55650930885814e-15 -0.624967182926059 1.70248077700642e-24 miRNAWalker2_validate -0.114314883374695 1.83733755300191e-14 27626488 Here we demonstrated that TGF-β1 elevated the expression of miR-155 in colorectal cancer cells through SMAD3 and SMAD4 colorectal cancer hsa-miR-21-3p SMAD4 2.17476065946878 5.15299442583591e-75 -0.624967182926059 1.70248077700642e-24 mirMAP -0.142251679213528 1.79438322002583e-18 NA NA NA hsa-miR-27a-3p SMAD4 0.388496361379095 1.42373532086331e-05 -0.624967182926059 1.70248077700642e-24 MirTarget -0.107318887613883 7.95509636261065e-06 NA NA NA hsa-miR-32-5p SMAD4 1.38676603945192 2.29428299685976e-34 -0.624967182926059 1.70248077700642e-24 mirMAP -0.104053876543456 9.38449586813502e-09 NA NA NA hsa-miR-361-5p SMAD4 -0.0996867547900457 0.095428250126326 -0.624967182926059 1.70248077700642e-24 mirMAP -0.13420862344236 0.000247319809078657 NA NA NA hsa-miR-589-5p SMAD4 0.367182541239722 1.67804815542873e-05 -0.624967182926059 1.70248077700642e-24 miRNATAP -0.184456440754787 1.53364140974385e-13 NA NA NA hsa-miR-93-5p SMAD4 1.01788600209314 1.24312921618126e-21 -0.624967182926059 1.70248077700642e-24 miRNAWalker2_validate;mirMAP;miRNATAP -0.118636275861089 1.4710971943885e-09 NA NA NA hsa-miR-590-3p SMAD7 1.27438512890514 1.03164723481469e-23 -0.126914187586443 0.0344522313625721 miRanda -0.104268769035866 1.5864687173614e-10 NA NA NA hsa-miR-107 SNAI2 0.678998026350662 2.56224148930538e-16 -0.929098872578741 6.81961748391463e-14 miRanda -0.375468335579203 1.4407813113722e-13 NA NA NA hsa-miR-148b-3p SNAI2 1.0552576751879 1.6679285705231e-29 -0.929098872578741 6.81961748391463e-14 miRNAWalker2_validate -0.35950918837567 2.88411069877523e-16 NA NA NA hsa-miR-182-5p SNAI2 2.36408084103818 2.60011457600281e-72 -0.929098872578741 6.81961748391463e-14 miRNAWalker2_validate;miRNATAP -0.310945077672776 1.14998297831868e-26 NA NA NA hsa-miR-200b-3p SNAI2 2.11744072703209 1.66710572104191e-43 -0.929098872578741 6.81961748391463e-14 TargetScan -0.244585452671317 7.0648050194561e-21 NA NA NA hsa-miR-200c-3p SNAI2 2.07038651806183 6.84613386286599e-51 -0.929098872578741 6.81961748391463e-14 miRNATAP -0.286974732040298 1.03468820627389e-23 NA NA NA hsa-miR-330-3p SNAI2 0.432728362037032 0.00041335506960812 -0.929098872578741 6.81961748391463e-14 PITA -0.131931156476665 0.000213082977743384 NA NA NA hsa-miR-375 SNAI2 2.09893673049766 1.68351780396203e-16 -0.929098872578741 6.81961748391463e-14 miRanda -0.147761834840226 9.62714562907298e-20 NA NA NA hsa-miR-429 SNAI2 2.84108892259147 3.88520896426515e-64 -0.929098872578741 6.81961748391463e-14 PITA;miRanda;miRNATAP -0.220374529254888 3.02724246604925e-21 NA NA NA hsa-miR-590-3p SNAI2 1.27438512890514 1.03164723481469e-23 -0.929098872578741 6.81961748391463e-14 PITA;miRanda;mirMAP -0.184741712755568 7.85062670862328e-08 NA NA NA hsa-miR-96-5p SNAI2 3.24596558166606 1.92296159041707e-98 -0.929098872578741 6.81961748391463e-14 miRNATAP -0.280366193015972 1.4231591750163e-31 NA NA NA hsa-let-7g-3p SOX2 0.5854327663695 0.000371711766083627 1.62824878642595 1.83270623627945e-06 miRNATAP -0.252097487839012 0.000403824116188777 NA NA NA hsa-miR-139-5p SOX2 -3.25846663863766 2.62018989415003e-112 1.62824878642595 1.83270623627945e-06 miRanda -0.218839977585125 0.00195260988534193 NA NA NA hsa-miR-145-5p SOX2 -2.62703571936687 7.64402900188551e-88 1.62824878642595 1.83270623627945e-06 miRNAWalker2_validate;miRTarBase -0.406343012519686 3.02930538603098e-07 20382729;21211035;22098779;25951106;22835608 Finally we provide evidence that EWS-FLI-1 and miRNA-145 function in a mutually repressive feedback loop and identify their common target gene SOX2 in addition to miRNA145 itself as key players in ESFT cell differentiation and tumorigenicity;We also show that miR-145 and SOX2 form a double negative feedback loop in GBM cells potentially creating a bistable system in GBM cells;In this study our miRNA/mRNA-microarray and RT-PCR analysis showed that the expression of miR145 a tumor-suppressive miRNA is inversely correlated with the levels of Oct4 and Sox2 in GBM-CD133+ cells and malignant glioma specimens; We demonstrated that miR145 negatively regulates GBM tumorigenesis by targeting Oct4 and Sox2 in GBM-CD133+;Overexpression of miR 145 5p inhibits proliferation of prostate cancer cells and reduces SOX2 expression; We proposed that miR-145-5p being an important regulator of SOX2 carries a crucial role in PCa tumorigenesis;miR-145 regulates SOX2 and OCT4 translation and p53 regulates miR-145 expression differentiation;;malignant trasformation;tumorigenesis;tumorigenesis; sarcoma;glioblastoma;glioblastoma;prostate cancer;lung squamous cell cancer hsa-miR-486-5p SOX2 -3.87258704301474 1.22658629378451e-80 1.62824878642595 1.83270623627945e-06 miRanda -0.165278281469295 0.00152309022494884 NA NA NA hsa-miR-491-5p SOX2 -1.04307210952796 1.14586501470398e-15 1.62824878642595 1.83270623627945e-06 miRanda -0.39247424908074 1.09391541296951e-05 NA NA NA hsa-miR-331-3p TCF7 0.74441480542886 1.17071235477799e-07 -0.912929918624152 7.6350583246167e-11 MirTarget;miRNATAP -0.153308578278305 7.71083941170175e-06 NA NA NA hsa-miR-141-3p TCF7L1 2.99777540204168 1.26370498493024e-78 -1.43757533529955 1.98162937384072e-20 miRNAWalker2_validate -0.199972471420516 6.28430074006789e-11 NA NA NA hsa-miR-200a-3p TCF7L1 2.55218480823434 2.96135446816238e-51 -1.43757533529955 1.98162937384072e-20 miRNAWalker2_validate -0.150558299078396 6.03400969336786e-07 NA NA NA hsa-miR-200b-3p TCF7L1 2.11744072703209 1.66710572104191e-43 -1.43757533529955 1.98162937384072e-20 miRNAWalker2_validate -0.168143697293025 5.41553060367198e-07 NA NA NA hsa-miR-200c-3p TCF7L1 2.07038651806183 6.84613386286599e-51 -1.43757533529955 1.98162937384072e-20 miRNAWalker2_validate -0.229533628135833 4.20710186780113e-10 NA NA NA hsa-miR-429 TCF7L1 2.84108892259147 3.88520896426515e-64 -1.43757533529955 1.98162937384072e-20 miRNAWalker2_validate -0.134496234177534 7.39492362051745e-06 NA NA NA hsa-miR-107 TCF7L2 0.678998026350662 2.56224148930538e-16 -1.35100342592875 2.87469707303853e-37 miRanda -0.247661729975441 3.82905437520373e-08 NA NA NA hsa-miR-148b-3p TCF7L2 1.0552576751879 1.6679285705231e-29 -1.35100342592875 2.87469707303853e-37 miRNAWalker2_validate -0.36003166883339 8.1210275031183e-21 NA NA NA hsa-miR-15b-3p TCF7L2 1.12898579025388 1.18050912917317e-14 -1.35100342592875 2.87469707303853e-37 miRNATAP -0.105562680055541 3.49079711601082e-05 NA NA NA hsa-miR-182-5p TCF7L2 2.36408084103818 2.60011457600281e-72 -1.35100342592875 2.87469707303853e-37 miRNATAP -0.285458372953323 5.15013518210834e-29 NA NA NA hsa-miR-183-5p TCF7L2 2.95681814393872 1.09965777344285e-92 -1.35100342592875 2.87469707303853e-37 MirTarget;miRNATAP -0.256342247617245 6.25752369970953e-30 NA NA NA hsa-miR-193a-3p TCF7L2 0.310617999804917 0.00477640270974957 -1.35100342592875 2.87469707303853e-37 miRanda -0.13669345972878 7.45997149176231e-05 NA NA NA hsa-miR-338-3p TCF7L2 0.0799903526884966 0.575137668326679 -1.35100342592875 2.87469707303853e-37 miRanda -0.164700048645429 4.65832433017924e-10 NA NA NA hsa-miR-342-3p TCF7L2 1.21944481975657 6.81914373001202e-19 -1.35100342592875 2.87469707303853e-37 miRanda -0.233358442684096 1.49785192802606e-18 NA NA NA hsa-miR-429 TCF7L2 2.84108892259147 3.88520896426515e-64 -1.35100342592875 2.87469707303853e-37 miRNATAP -0.171121027184894 1.09303298527548e-16 NA NA NA hsa-miR-590-3p TCF7L2 1.27438512890514 1.03164723481469e-23 -1.35100342592875 2.87469707303853e-37 miRanda -0.121584977112315 6.35614091956812e-05 NA NA NA hsa-miR-625-5p TCF7L2 0.728939236913178 5.97591217674307e-08 -1.35100342592875 2.87469707303853e-37 MirTarget -0.196349842308205 7.37475139500119e-12 NA NA NA hsa-miR-96-5p TCF7L2 3.24596558166606 1.92296159041707e-98 -1.35100342592875 2.87469707303853e-37 MirTarget;TargetScan;miRNATAP -0.237827941772781 2.94405056699388e-29 NA NA NA hsa-miR-99b-3p TCF7L2 0.617175730947012 6.04327581183627e-09 -1.35100342592875 2.87469707303853e-37 MirTarget;miRNATAP -0.144432671942689 4.79981484254922e-05 NA NA NA hsa-miR-103a-3p TEAD1 0.610673390034345 1.63113920514646e-12 -1.39931853829988 3.11111186209198e-44 mirMAP -0.420025141684808 3.48575709821296e-25 NA NA NA hsa-miR-106b-5p TEAD1 1.22477789913175 2.31787213143326e-32 -1.39931853829988 3.11111186209198e-44 mirMAP -0.361696167297458 2.49261433702256e-28 NA NA NA hsa-miR-107 TEAD1 0.678998026350662 2.56224148930538e-16 -1.39931853829988 3.11111186209198e-44 mirMAP -0.34349760405371 7.50428082947106e-16 NA NA NA hsa-miR-128-3p TEAD1 0.90296715955238 9.925204823863e-23 -1.39931853829988 3.11111186209198e-44 MirTarget -0.341410279874523 1.66728578067198e-19 NA NA NA hsa-miR-130b-3p TEAD1 1.38122163823846 1.00932179737836e-26 -1.39931853829988 3.11111186209198e-44 mirMAP -0.156972202836739 8.2627206529718e-09 NA NA NA hsa-miR-141-3p TEAD1 2.99777540204168 1.26370498493024e-78 -1.39931853829988 3.11111186209198e-44 mirMAP -0.263313439559027 3.49779352863607e-41 NA NA NA hsa-miR-146b-5p TEAD1 0.631041661167954 6.20366593452965e-08 -1.39931853829988 3.11111186209198e-44 PITA;miRanda -0.190583005976855 5.49013911559959e-10 NA NA NA hsa-miR-148b-3p TEAD1 1.0552576751879 1.6679285705231e-29 -1.39931853829988 3.11111186209198e-44 MirTarget -0.139078914267416 0.000214125034777631 NA NA NA hsa-miR-16-1-3p TEAD1 1.30142784811196 2.53343713753744e-29 -1.39931853829988 3.11111186209198e-44 MirTarget;mirMAP -0.205553448221515 1.06765176716152e-10 NA NA NA hsa-miR-17-5p TEAD1 0.599531757298529 1.07318660415906e-05 -1.39931853829988 3.11111186209198e-44 mirMAP -0.12560718052684 2.06087951938293e-06 NA NA NA hsa-miR-181a-5p TEAD1 0.635863607630183 6.72486918157744e-11 -1.39931853829988 3.11111186209198e-44 mirMAP;miRNATAP -0.288438899259988 2.43995919405274e-15 NA NA NA hsa-miR-181b-5p TEAD1 1.22749257795094 1.21998198830919e-27 -1.39931853829988 3.11111186209198e-44 mirMAP;miRNATAP -0.315164726538427 2.99888929784249e-25 NA NA NA hsa-miR-181c-5p TEAD1 0.574847839298605 4.51287502066478e-07 -1.39931853829988 3.11111186209198e-44 mirMAP;miRNATAP -0.158810493586811 5.01905297152746e-07 NA NA NA hsa-miR-182-5p TEAD1 2.36408084103818 2.60011457600281e-72 -1.39931853829988 3.11111186209198e-44 mirMAP;miRNATAP -0.212255128480128 1.04317587028191e-17 NA NA NA hsa-miR-185-5p TEAD1 0.482334746589337 3.68475879959415e-09 -1.39931853829988 3.11111186209198e-44 MirTarget;miRNATAP -0.368864791152627 2.33389101066452e-17 NA NA NA hsa-miR-192-5p TEAD1 1.33366224451777 9.5116159697107e-29 -1.39931853829988 3.11111186209198e-44 mirMAP -0.101712824487868 0.000513131789547005 NA NA NA hsa-miR-194-5p TEAD1 0.467781870340114 1.0386810618625e-07 -1.39931853829988 3.11111186209198e-44 MirTarget -0.168216467247601 4.36851163511298e-05 NA NA NA hsa-miR-19a-3p TEAD1 0.817507952171848 3.76285090469625e-08 -1.39931853829988 3.11111186209198e-44 mirMAP -0.15258631328349 2.16917490283228e-10 NA NA NA hsa-miR-200a-3p TEAD1 2.55218480823434 2.96135446816238e-51 -1.39931853829988 3.11111186209198e-44 mirMAP -0.223034041783001 2.66140349888619e-30 NA NA NA hsa-miR-200a-5p TEAD1 2.58844508672328 1.79650654234569e-56 -1.39931853829988 3.11111186209198e-44 miRNATAP -0.175995453381413 4.18244793430942e-18 NA NA NA hsa-miR-200b-3p TEAD1 2.11744072703209 1.66710572104191e-43 -1.39931853829988 3.11111186209198e-44 TargetScan -0.246914111025017 5.14311134476288e-30 NA NA NA hsa-miR-200c-3p TEAD1 2.07038651806183 6.84613386286599e-51 -1.39931853829988 3.11111186209198e-44 miRNATAP -0.302039970867764 1.97528873326621e-37 NA NA NA hsa-miR-20a-5p TEAD1 0.44979911120222 0.000602386964327228 -1.39931853829988 3.11111186209198e-44 mirMAP -0.219950055678797 6.29335821539342e-16 NA NA NA hsa-miR-21-3p TEAD1 2.17476065946878 5.15299442583591e-75 -1.39931853829988 3.11111186209198e-44 mirMAP -0.203015123838267 1.60980082892842e-13 NA NA NA hsa-miR-25-3p TEAD1 -0.00546790775985073 0.944061771389468 -1.39931853829988 3.11111186209198e-44 miRNATAP -0.211405606723731 6.56030047644039e-06 NA NA NA hsa-miR-27a-3p TEAD1 0.388496361379095 1.42373532086331e-05 -1.39931853829988 3.11111186209198e-44 miRNATAP -0.106862674686357 0.00856764572660699 NA NA NA hsa-miR-29b-3p TEAD1 0.438847962603729 6.46722433236121e-05 -1.39931853829988 3.11111186209198e-44 mirMAP -0.183513161516108 2.25114352482891e-08 NA NA NA hsa-miR-29c-3p TEAD1 -0.0652732378039769 0.563774115756922 -1.39931853829988 3.11111186209198e-44 mirMAP -0.20162760141038 2.73891228151083e-10 NA NA NA hsa-miR-3065-3p TEAD1 1.62787885002468 6.81477830005026e-19 -1.39931853829988 3.11111186209198e-44 miRNATAP -0.131881439029362 5.59920041276476e-12 NA NA NA hsa-miR-30d-3p TEAD1 0.264544633563642 0.00755023189129747 -1.39931853829988 3.11111186209198e-44 MirTarget -0.145407986254096 7.57976468319874e-05 NA NA NA hsa-miR-32-5p TEAD1 1.38676603945192 2.29428299685976e-34 -1.39931853829988 3.11111186209198e-44 miRNATAP -0.271564047241166 1.91313152297333e-19 NA NA NA hsa-miR-340-5p TEAD1 1.0857159627596 4.94471062546756e-24 -1.39931853829988 3.11111186209198e-44 mirMAP -0.321927224143922 1.16849557144091e-23 NA NA NA hsa-miR-425-5p TEAD1 0.719898949241718 6.01079610190374e-08 -1.39931853829988 3.11111186209198e-44 mirMAP -0.104794821048392 0.00011081751565495 NA NA NA hsa-miR-429 TEAD1 2.84108892259147 3.88520896426515e-64 -1.39931853829988 3.11111186209198e-44 PITA;miRNATAP -0.223254951104642 8.62521560232663e-31 NA NA NA hsa-miR-454-3p TEAD1 1.28177672191095 6.84024979484587e-21 -1.39931853829988 3.11111186209198e-44 mirMAP -0.124395936761948 1.71574023457789e-06 NA NA NA hsa-miR-532-5p TEAD1 0.0386976222860582 0.682018574136515 -1.39931853829988 3.11111186209198e-44 PITA;miRNATAP -0.136541330789954 0.000409901748423026 NA NA NA hsa-miR-590-3p TEAD1 1.27438512890514 1.03164723481469e-23 -1.39931853829988 3.11111186209198e-44 MirTarget;PITA;miRanda;miRNATAP -0.195604555026579 1.10262586225919e-11 NA NA NA hsa-miR-93-5p TEAD1 1.01788600209314 1.24312921618126e-21 -1.39931853829988 3.11111186209198e-44 mirMAP -0.339909152780622 8.18256809019937e-26 NA NA NA hsa-miR-96-5p TEAD1 3.24596558166606 1.92296159041707e-98 -1.39931853829988 3.11111186209198e-44 TargetScan;miRNATAP -0.228540035306696 1.37292843795799e-29 NA NA NA hsa-miR-98-5p TEAD1 0.656336869298973 9.03113188590466e-15 -1.39931853829988 3.11111186209198e-44 miRNAWalker2_validate -0.245326704225081 5.93326829883935e-09 NA NA NA hsa-let-7b-5p TEAD3 -0.54215483448257 7.21347617597858e-08 0.228810162682856 0.000446892453691191 miRNATAP -0.125477925561954 1.12539764166708e-08 NA NA NA hsa-let-7g-5p TEAD3 0.0200025784917734 0.791635298815256 0.228810162682856 0.000446892453691191 miRNATAP -0.112630377707972 0.000155766077815877 NA NA NA hsa-miR-744-5p TGFB1 0.114590984077262 0.312916425462546 0.9572932995293 2.60884198670166e-26 miRNAWalker2_validate;miRNATAP -0.166126823806423 2.82828117413693e-09 NA NA NA hsa-miR-107 TGFB2 0.678998026350662 2.56224148930538e-16 -0.568239705690126 0.00206510120463672 miRanda -0.401875565283925 8.76701815465238e-08 NA NA NA hsa-miR-141-3p TGFB2 2.99777540204168 1.26370498493024e-78 -0.568239705690126 0.00206510120463672 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.201139839320628 1.72029232417547e-08 NA NA NA hsa-miR-148b-3p TGFB2 1.0552576751879 1.6679285705231e-29 -0.568239705690126 0.00206510120463672 MirTarget -0.422618628558287 7.82755899138552e-11 NA NA NA hsa-miR-149-5p TGFB2 0.218233101703391 0.261629158371175 -0.568239705690126 0.00206510120463672 MirTarget;miRNATAP -0.129221359501958 7.02534131250114e-05 NA NA NA hsa-miR-193a-3p TGFB2 0.310617999804917 0.00477640270974957 -0.568239705690126 0.00206510120463672 MirTarget;miRanda;miRNATAP -0.385790006047712 1.31529188795393e-11 NA NA NA hsa-miR-193b-3p TGFB2 -0.0550374855074773 0.65382485898551 -0.568239705690126 0.00206510120463672 MirTarget;miRNATAP -0.171503498781225 0.000913844156376696 NA NA NA hsa-miR-200a-3p TGFB2 2.55218480823434 2.96135446816238e-51 -0.568239705690126 0.00206510120463672 MirTarget;miRNATAP -0.157197308079383 7.61768751897913e-06 25813153 Tumor suppressive microRNA 200a inhibits renal cell carcinoma development by directly targeting TGFB2; By performing quantitative real-time PCR ELISA and luciferase reporter assays transforming growth factor beta2 TGFB2 was validated as a direct target gene of miR-200a; Moreover siRNA-mediated knockdown of TGFB2 partially phenocopied the effect of miR-200a overexpression; These results suggest that miR-200a suppresses RCC development via directly targeting TGFB2 indicating that miR-200a may present a novel target for diagnostic and therapeutic strategies in RCC kidney renal cell cancer hsa-miR-29b-3p TGFB2 0.438847962603729 6.46722433236121e-05 -0.568239705690126 0.00206510120463672 miRTarBase;MirTarget;miRNATAP -0.435812547346718 1.64777033866721e-14 NA NA NA hsa-miR-29c-3p TGFB2 -0.0652732378039769 0.563774115756922 -0.568239705690126 0.00206510120463672 MirTarget;miRNATAP -0.393270636676739 1.42982951467692e-12 NA NA NA hsa-miR-301a-3p TGFB2 1.32170168375632 2.12280368957514e-15 -0.568239705690126 0.00206510120463672 MirTarget;miRNATAP -0.168650734197616 6.85924013793372e-06 NA NA NA hsa-miR-330-3p TGFB2 0.432728362037032 0.00041335506960812 -0.568239705690126 0.00206510120463672 miRNATAP -0.169099911709115 0.00123359688318399 NA NA NA hsa-miR-330-5p TGFB2 0.626063225953928 3.42215028606779e-09 -0.568239705690126 0.00206510120463672 miRanda -0.231096330328837 9.82035598821339e-05 NA NA NA hsa-miR-331-5p TGFB2 0.682437632502949 4.10871642662371e-11 -0.568239705690126 0.00206510120463672 miRNATAP -0.256828592209254 2.39839780265118e-05 NA NA NA hsa-miR-375 TGFB2 2.09893673049766 1.68351780396203e-16 -0.568239705690126 0.00206510120463672 miRNAWalker2_validate -0.118032596246175 1.14664596099986e-06 NA NA NA hsa-miR-429 TGFB2 2.84108892259147 3.88520896426515e-64 -0.568239705690126 0.00206510120463672 miRNATAP -0.113931562701627 0.00112595441618086 NA NA NA hsa-miR-454-3p TGFB2 1.28177672191095 6.84024979484587e-21 -0.568239705690126 0.00206510120463672 MirTarget;miRNATAP -0.21652241903686 1.80168797038491e-06 NA NA NA hsa-miR-590-3p TGFB2 1.27438512890514 1.03164723481469e-23 -0.568239705690126 0.00206510120463672 mirMAP -0.218778123275247 1.55472558560304e-05 NA NA NA hsa-miR-590-5p TGFB2 0.746515607868274 8.51300479640125e-09 -0.568239705690126 0.00206510120463672 miRanda;miRNATAP -0.127583678067132 0.00859946694127918 NA NA NA hsa-let-7a-3p TGFB3 0.466622567891891 3.70886257943079e-07 0.82398957056453 1.83180841509129e-11 MirTarget -0.23002281448221 5.95409654478238e-07 NA NA NA hsa-let-7f-1-3p TGFB3 0.37532726250321 0.00156021688753682 0.82398957056453 1.83180841509129e-11 MirTarget -0.195594535331808 6.10557486170201e-08 NA NA NA hsa-miR-151a-5p TGFB3 0.509210376738198 3.17540030607215e-07 0.82398957056453 1.83180841509129e-11 MirTarget -0.460270915838936 5.41462985077644e-29 NA NA NA hsa-miR-26b-3p TGFB3 -0.62588114643887 3.30712936204727e-06 0.82398957056453 1.83180841509129e-11 MirTarget -0.166318643088715 1.09180542813277e-07 NA NA NA hsa-miR-29a-3p TGFB3 -0.699539666833076 1.13935003139957e-13 0.82398957056453 1.83180841509129e-11 miRNAWalker2_validate -0.215592947893623 1.26387377494944e-06 NA NA NA hsa-miR-29b-3p TGFB3 0.438847962603729 6.46722433236121e-05 0.82398957056453 1.83180841509129e-11 miRTarBase -0.300724044682202 2.93536952356929e-15 NA NA NA hsa-miR-511-5p TGFB3 -2.27545475897362 3.84085514050558e-36 0.82398957056453 1.83180841509129e-11 MirTarget -0.161630488068991 4.28099557548626e-13 NA NA NA hsa-miR-590-3p TGFB3 1.27438512890514 1.03164723481469e-23 0.82398957056453 1.83180841509129e-11 miRanda -0.276040958504426 1.7943368211393e-16 NA NA NA hsa-miR-629-3p TGFB3 1.25035919247365 3.91361135469024e-14 0.82398957056453 1.83180841509129e-11 MirTarget -0.184738491466436 9.18913270065683e-13 NA NA NA hsa-let-7a-5p TGFBR1 -0.210286642041636 0.0072546234707717 -0.276773756857041 0.00374479166499862 TargetScan;miRNATAP -0.135014125369019 0.00134477571196012 27234654 rs868 is contained in a let-7 miRNA binding site in the 3'UTR of TGFBR1 which might provide a functional basis for the association in MSS HNPCC colorectal cancer hsa-miR-101-3p TGFBR1 -0.126035286271986 0.145997832808138 -0.276773756857041 0.00374479166499862 miRNAWalker2_validate;miRNATAP -0.226110526180146 2.07174805788194e-09 NA NA NA hsa-miR-128-3p TGFBR1 0.90296715955238 9.925204823863e-23 -0.276773756857041 0.00374479166499862 miRNAWalker2_validate;miRTarBase -0.157338866756433 5.76850179866576e-06 NA NA NA hsa-miR-200b-3p TGFBR1 2.11744072703209 1.66710572104191e-43 -0.276773756857041 0.00374479166499862 mirMAP -0.133382190063293 2.90573705377005e-11 20498632 Inhibition of TGFbeta receptor 1 TGFBR1 in these cells induced MET and reduction of prometastatic miR-21 but caused an increase of the miR-200 family thyroid cancer hsa-miR-320a TGFBR1 -0.287921276129346 0.00141693637596294 -0.276773756857041 0.00374479166499862 PITA;miRanda;miRNATAP -0.136624380256683 0.000172858923508737 NA NA NA hsa-miR-338-3p TGFBR1 0.0799903526884966 0.575137668326679 -0.276773756857041 0.00374479166499862 miRanda -0.16505256729074 3.45773945956773e-13 NA NA NA hsa-miR-340-5p TGFBR1 1.0857159627596 4.94471062546756e-24 -0.276773756857041 0.00374479166499862 mirMAP -0.126480744659732 2.00427959104962e-05 NA NA NA hsa-miR-361-5p TGFBR1 -0.0996867547900457 0.095428250126326 -0.276773756857041 0.00374479166499862 miRanda;mirMAP;miRNATAP -0.343826208469508 4.82441885336511e-10 NA NA NA hsa-miR-429 TGFBR1 2.84108892259147 3.88520896426515e-64 -0.276773756857041 0.00374479166499862 miRanda;miRNATAP -0.101210444459427 1.79034747294782e-08 NA NA NA hsa-miR-98-5p TGFBR1 0.656336869298973 9.03113188590466e-15 -0.276773756857041 0.00374479166499862 miRNAWalker2_validate -0.153945603415794 5.62215521493057e-05 NA NA NA hsa-miR-106a-5p TGFBR2 0.574594373206545 0.000145868284001732 -2.39529308737339 4.9899056025782e-85 miRTarBase;miRNATAP -0.167004125374202 5.11178559030175e-08 22912877 MiR-106a inhibits the expression of transforming growth factor-β receptor 2 TGFBR2 leading to increased CRC cell migration and invasion cell migration colorectal cancer hsa-miR-106b-5p TGFBR2 1.22477789913175 2.31787213143326e-32 -2.39529308737339 4.9899056025782e-85 miRNATAP -0.583213497349775 2.44964235169299e-45 NA NA NA hsa-miR-107 TGFBR2 0.678998026350662 2.56224148930538e-16 -2.39529308737339 4.9899056025782e-85 miRanda;miRNATAP -0.530917906321599 1.66581882091816e-22 NA NA NA hsa-miR-130b-3p TGFBR2 1.38122163823846 1.00932179737836e-26 -2.39529308737339 4.9899056025782e-85 miRNAWalker2_validate;miRNATAP -0.355697993280506 3.73635681408915e-25 25024357 Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC lung squamous cell cancer hsa-miR-17-5p TGFBR2 0.599531757298529 1.07318660415906e-05 -2.39529308737339 4.9899056025782e-85 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.344837157501155 3.26279419912174e-25 25011053;27120811 We demonstrate that miR-17 overexpression interferes with the TGFβ-EMT axis and hinders RCC sphere formation; and validated TGFBR2 as a direct and biologically relevant target during this process;MiR-17-5p was found to bind to the 3'UTR of TGFBR2 mRNA and further validation of this specific binding was performed through a reporter assay; An inverse correlation between miR-17-5p and TGFBR2 protein was observed in gastric cancer tissues; Cell studies revealed that miR-17-5p negatively regulated TGFBR2 expression by directly binding to the 3'UTR of TGFBR2 mRNA thereby promoting cell growth and migration; The results of our study suggest a novel regulatory network in gastric cancer mediated by miR-17-5p and TGFBR2 and may indicate that TGFBR2 could serve as a new therapeutic target in gastric cancer ; kidney renal cell cancer;gastric cancer hsa-miR-18a-5p TGFBR2 0.969066793715868 1.69069796425892e-08 -2.39529308737339 4.9899056025782e-85 miRNAWalker2_validate -0.233316456798081 1.26332307500906e-18 NA NA NA hsa-miR-19a-3p TGFBR2 0.817507952171848 3.76285090469625e-08 -2.39529308737339 4.9899056025782e-85 miRNAWalker2_validate;miRNATAP -0.295433323573397 3.17340161137166e-22 NA NA NA hsa-miR-19b-3p TGFBR2 0.139124391010031 0.255658553872934 -2.39529308737339 4.9899056025782e-85 miRNAWalker2_validate;miRNATAP -0.23529469963531 5.83073772392392e-10 NA NA NA hsa-miR-20a-5p TGFBR2 0.44979911120222 0.000602386964327228 -2.39529308737339 4.9899056025782e-85 miRNAWalker2_validate;miRTarBase;miRNATAP -0.346418250547717 1.79003902635661e-23 NA NA NA hsa-miR-20b-5p TGFBR2 0.78236583455125 8.7938334801223e-05 -2.39529308737339 4.9899056025782e-85 miRNATAP -0.101055475114644 1.4278146071271e-05 NA NA NA hsa-miR-21-5p TGFBR2 2.32007501846389 3.08394781855554e-137 -2.39529308737339 4.9899056025782e-85 miRNAWalker2_validate;miRTarBase;miRNATAP -0.537594809270263 3.47307989185754e-40 24037531 Androgen receptor and microRNA 21 axis downregulates transforming growth factor beta receptor II TGFBR2 expression in prostate cancer; Our results revealed that miR-21 suppresses TGFBR2 levels by binding to its 3'-UTR and AR signaling further potentiates this effect in both untransformed and transformed human prostate epithelial cells as well as in human prostate cancers; Manipulation of androgen signaling or the expression levels of AR or miR-21 negatively altered TGFBR2 expression in untransformed and transformed human prostate epithelial cells human prostate cancer xenografts and mouse prostate glands; Together these results suggest that the AR and miR-21 axis exerts its oncogenic effects in prostate tumors by downregulating TGFBR2 hence inhibiting the tumor-suppressive activity of TGFβ pathway prostate cancer hsa-miR-301a-3p TGFBR2 1.32170168375632 2.12280368957514e-15 -2.39529308737339 4.9899056025782e-85 miRNATAP -0.317266296975964 1.73201531962553e-32 25551793 MicroRNA 301a promotes migration and invasion by targeting TGFBR2 in human colorectal cancer; TGFBR2 was identified to be the downstream target of miR-301a; Knockdown of TGFBR2 in cells treated by miR-301a inhibitor elevated the previously abrogated migration and invasion; Our data indicated that miR-301a correlated with the metastatic and invasive ability in human colorectal cancers and miR-301a exerted its role as oncogene by targeting TGFBR2 colorectal cancer hsa-miR-320b TGFBR2 0.412787504747938 0.00113457276903985 -2.39529308737339 4.9899056025782e-85 miRanda;miRNATAP -0.208017816637935 1.58734456312155e-08 NA NA NA hsa-miR-340-5p TGFBR2 1.0857159627596 4.94471062546756e-24 -2.39529308737339 4.9899056025782e-85 mirMAP -0.314168975517319 6.41119882395371e-14 NA NA NA hsa-miR-429 TGFBR2 2.84108892259147 3.88520896426515e-64 -2.39529308737339 4.9899056025782e-85 miRNATAP -0.404995702801572 1.14853648012577e-64 NA NA NA hsa-miR-454-3p TGFBR2 1.28177672191095 6.84024979484587e-21 -2.39529308737339 4.9899056025782e-85 miRNATAP -0.384614615164931 1.36686238358356e-32 NA NA NA hsa-miR-590-3p TGFBR2 1.27438512890514 1.03164723481469e-23 -2.39529308737339 4.9899056025782e-85 miRanda -0.338025545666787 3.04278770804611e-20 NA NA NA hsa-miR-590-5p TGFBR2 0.746515607868274 8.51300479640125e-09 -2.39529308737339 4.9899056025782e-85 miRNAWalker2_validate;miRTarBase;PITA;miRanda;miRNATAP -0.286652524899627 4.12566791851325e-16 NA NA NA hsa-miR-9-5p TGFBR2 0.734772328078424 0.00261982843636383 -2.39529308737339 4.9899056025782e-85 miRNATAP -0.11967052909348 2.52866655443074e-10 25024357 Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC lung squamous cell cancer hsa-miR-92a-3p TGFBR2 -0.342420481092807 0.000732275969501111 -2.39529308737339 4.9899056025782e-85 miRNAWalker2_validate -0.223515332507838 1.18491745689284e-06 NA NA NA hsa-miR-93-5p TGFBR2 1.01788600209314 1.24312921618126e-21 -2.39529308737339 4.9899056025782e-85 miRNAWalker2_validate;miRNATAP -0.609999323446729 8.30075605455623e-52 NA NA NA hsa-miR-142-3p TP73 1.53951237846104 2.06769936282034e-17 0.496595627051834 0.00711519755707105 miRanda -0.108361163843328 0.00152822881326152 NA NA NA hsa-miR-17-5p TP73 0.599531757298529 1.07318660415906e-05 0.496595627051834 0.00711519755707105 TargetScan -0.203686242683378 1.02722430405108e-05 NA NA NA hsa-miR-185-3p TP73 0.86591374114446 7.8790769678542e-10 0.496595627051834 0.00711519755707105 mirMAP -0.183884886307054 4.66034322076237e-05 NA NA NA hsa-miR-18a-5p TP73 0.969066793715868 1.69069796425892e-08 0.496595627051834 0.00711519755707105 mirMAP -0.22065384786784 1.19104385169831e-09 NA NA NA hsa-miR-193a-3p TP73 0.310617999804917 0.00477640270974957 0.496595627051834 0.00711519755707105 mirMAP -0.197004379067467 0.000621164084168105 NA NA NA hsa-miR-193a-5p TP73 -1.1508321886378 7.11949564429669e-37 0.496595627051834 0.00711519755707105 miRNAWalker2_validate;miRTarBase -0.351916782344534 1.29390251794395e-07 NA NA NA hsa-miR-193b-3p TP73 -0.0550374855074773 0.65382485898551 0.496595627051834 0.00711519755707105 mirMAP -0.157254709074547 0.00236776333910672 NA NA NA hsa-miR-193b-5p TP73 -0.481487407783336 0.000206895781789619 0.496595627051834 0.00711519755707105 mirMAP -0.198931618079958 4.35355859092893e-05 NA NA NA hsa-miR-22-3p TP73 -0.505819481364718 1.90494905330622e-13 0.496595627051834 0.00711519755707105 mirMAP -0.759467448867156 3.55463657661265e-17 NA NA NA hsa-miR-24-3p TP73 -0.120123317289941 0.21432376743243 0.496595627051834 0.00711519755707105 mirMAP -0.467949268895104 5.91964089212465e-13 NA NA NA hsa-miR-335-5p TP73 -2.61355235628987 2.6462884165886e-51 0.496595627051834 0.00711519755707105 mirMAP -0.10921364812323 0.00145304472317377 NA NA NA hsa-miR-455-3p TP73 0.678392920628872 0.000327758844555877 0.496595627051834 0.00711519755707105 miRNATAP -0.185388951410672 2.32743990387076e-08 NA NA NA hsa-miR-455-5p TP73 0.284641224662773 0.0357572339594277 0.496595627051834 0.00711519755707105 miRanda -0.137732293809756 0.00323425781963572 NA NA NA hsa-miR-590-3p TP73 1.27438512890514 1.03164723481469e-23 0.496595627051834 0.00711519755707105 miRanda -0.165559321629956 0.00110203699587496 NA NA NA hsa-miR-93-3p TP73 0.627759242044891 3.62527588304617e-06 0.496595627051834 0.00711519755707105 mirMAP -0.157246835549092 0.000717329988883304 NA NA NA hsa-miR-664a-3p WNT10A -0.237699857923843 0.0197071390183375 0.117967940665565 0.575368915720145 mirMAP -0.421214281367344 2.22889192706043e-09 NA NA NA hsa-miR-148a-3p WNT10B 0.706969798912638 5.52538085480485e-09 -1.41823796113152 2.7990884610486e-14 MirTarget -0.225697074269929 2.08337307308921e-05 NA NA NA hsa-miR-148b-3p WNT10B 1.0552576751879 1.6679285705231e-29 -1.41823796113152 2.7990884610486e-14 MirTarget -0.328579720045847 9.29413365918993e-07 NA NA NA hsa-miR-342-3p WNT10B 1.21944481975657 6.81914373001202e-19 -1.41823796113152 2.7990884610486e-14 miRanda -0.184377326541959 6.55689831892104e-05 NA NA NA hsa-miR-429 WNT11 2.84108892259147 3.88520896426515e-64 -2.30325701780235 1.00447815143943e-22 miRNATAP -0.283953214425953 3.59806376562941e-10 NA NA NA hsa-miR-590-3p WNT11 1.27438512890514 1.03164723481469e-23 -2.30325701780235 1.00447815143943e-22 miRanda -0.293944853552164 8.66172138800842e-06 NA NA NA hsa-miR-139-5p WNT2 -3.25846663863766 2.62018989415003e-112 0.997314912839432 9.86785362783619e-08 miRanda -0.250813000106968 6.69310140321002e-11 NA NA NA hsa-miR-335-3p WNT2 -1.88448538773649 2.09538234398335e-32 0.997314912839432 9.86785362783619e-08 mirMAP -0.124921231734074 0.0013759064532322 NA NA NA hsa-miR-361-3p WNT2 -0.0370446538644886 0.624902392829872 0.997314912839432 9.86785362783619e-08 MirTarget -0.266339316841169 0.00199408748413513 NA NA NA hsa-miR-130b-3p WNT2B 1.38122163823846 1.00932179737836e-26 -0.785015258390785 3.85219049480573e-09 MirTarget -0.16709837520953 1.43976112122382e-06 NA NA NA hsa-miR-301a-3p WNT2B 1.32170168375632 2.12280368957514e-15 -0.785015258390785 3.85219049480573e-09 MirTarget -0.104564831857354 0.000130211401798741 NA NA NA hsa-miR-429 WNT2B 2.84108892259147 3.88520896426515e-64 -0.785015258390785 3.85219049480573e-09 miRNATAP -0.137551404474967 5.5132158702989e-08 NA NA NA hsa-miR-454-3p WNT2B 1.28177672191095 6.84024979484587e-21 -0.785015258390785 3.85219049480573e-09 MirTarget -0.174716398885358 1.14167579103774e-07 NA NA NA hsa-miR-146a-5p WNT3 0.102405752365098 0.486975378688068 0.707252279816307 1.60330481675813e-05 MirTarget -0.201603839063412 1.26011961583069e-07 NA NA NA hsa-miR-146b-5p WNT3 0.631041661167954 6.20366593452965e-08 0.707252279816307 1.60330481675813e-05 MirTarget;PITA;miRanda;miRNATAP -0.19864051897856 3.55693736099291e-05 NA NA NA hsa-miR-214-3p WNT3 -0.523705501275844 0.000211299789901139 0.707252279816307 1.60330481675813e-05 MirTarget -0.217458243957451 4.77314673966333e-08 NA NA NA hsa-miR-215-5p WNT3 -1.35643065897947 2.3180023440257e-20 0.707252279816307 1.60330481675813e-05 miRNAWalker2_validate -0.202617944190342 6.29886106348422e-08 NA NA NA hsa-miR-374a-3p WNT3 0.34122393953022 2.28714105382856e-05 0.707252279816307 1.60330481675813e-05 MirTarget -0.289753487107474 3.61014430173007e-05 NA NA NA hsa-miR-374a-5p WNT3 -0.239709888246804 0.00309819667153627 0.707252279816307 1.60330481675813e-05 MirTarget -0.450647176110379 8.40472532505734e-11 NA NA NA hsa-miR-374b-5p WNT3 -0.466781429946153 1.17238311619116e-08 0.707252279816307 1.60330481675813e-05 MirTarget -0.339662315482385 7.32586953128491e-07 NA NA NA hsa-miR-376c-3p WNT3 -1.23221625820254 6.08631316990405e-17 0.707252279816307 1.60330481675813e-05 MirTarget -0.209776014145028 2.6988219390376e-08 NA NA NA hsa-miR-576-5p WNT3 0.0649387707567879 0.588791966096287 0.707252279816307 1.60330481675813e-05 mirMAP -0.138865149881875 0.0032152515286964 NA NA NA hsa-miR-589-3p WNT3 0.0263457630961427 0.866577983997705 0.707252279816307 1.60330481675813e-05 mirMAP -0.105204288945704 0.00433518385741643 NA NA NA hsa-miR-16-5p WNT3A 0.46835991343556 1.91125356547776e-06 0.138281478831945 0.560611727974706 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.223562434556754 0.00686252591255575 NA NA NA hsa-miR-331-3p WNT3A 0.74441480542886 1.17071235477799e-07 0.138281478831945 0.560611727974706 mirMAP -0.186748490696253 0.00116808678187749 NA NA NA hsa-miR-335-5p WNT3A -2.61355235628987 2.6462884165886e-51 0.138281478831945 0.560611727974706 mirMAP -0.144104496367168 0.00107984254818266 NA NA NA hsa-let-7a-3p WNT5A 0.466622567891891 3.70886257943079e-07 -0.0987969676790623 0.559050375624812 miRNATAP -0.22117753231769 0.000441970481202632 NA NA NA hsa-miR-141-3p WNT5A 2.99777540204168 1.26370498493024e-78 -0.0987969676790623 0.559050375624812 TargetScan -0.139214845204003 2.12785375749739e-05 NA NA NA hsa-miR-144-5p WNT5A -2.75914786146772 1.55794225315972e-50 -0.0987969676790623 0.559050375624812 mirMAP -0.108189974261664 0.000232182868580216 NA NA NA hsa-miR-15b-3p WNT5A 1.12898579025388 1.18050912917317e-14 -0.0987969676790623 0.559050375624812 mirMAP -0.282465371884018 2.03011972026487e-13 NA NA NA hsa-miR-16-2-3p WNT5A 0.286355254959005 0.0256946046884474 -0.0987969676790623 0.559050375624812 MirTarget;mirMAP -0.339885804294178 3.30301649240528e-14 NA NA NA hsa-miR-16-5p WNT5A 0.46835991343556 1.91125356547776e-06 -0.0987969676790623 0.559050375624812 miRNAWalker2_validate -0.443371863255678 2.01154967356747e-14 NA NA NA hsa-miR-186-5p WNT5A -0.426987301460247 1.04129380549315e-05 -0.0987969676790623 0.559050375624812 miRNAWalker2_validate;mirMAP;miRNATAP -0.302944959464288 3.52342706593741e-07 NA NA NA hsa-miR-29a-5p WNT5A 0.334183773952055 0.00445137265870197 -0.0987969676790623 0.559050375624812 mirMAP -0.173390051712273 0.000449511750498096 NA NA NA hsa-miR-30b-5p WNT5A -0.46540603860146 2.4709940429591e-05 -0.0987969676790623 0.559050375624812 mirMAP -0.221268990849156 2.30222342732902e-05 NA NA NA hsa-miR-30c-5p WNT5A -0.393222674580066 8.06961465717306e-05 -0.0987969676790623 0.559050375624812 mirMAP -0.153444255475845 0.00829557687465555 NA NA NA hsa-miR-30d-3p WNT5A 0.264544633563642 0.00755023189129747 -0.0987969676790623 0.559050375624812 mirMAP -0.328486161205366 1.77036516167105e-08 NA NA NA hsa-miR-30d-5p WNT5A -0.247082219011045 0.00406717930063148 -0.0987969676790623 0.559050375624812 mirMAP -0.395918928140374 3.76530346593888e-09 NA NA NA hsa-miR-30e-5p WNT5A 0.293491764699475 0.000372291967271834 -0.0987969676790623 0.559050375624812 mirMAP -0.355937424695316 3.98104999357833e-07 NA NA NA hsa-miR-330-5p WNT5A 0.626063225953928 3.42215028606779e-09 -0.0987969676790623 0.559050375624812 miRanda -0.254694138871707 2.53849290717674e-06 NA NA NA hsa-miR-340-5p WNT5A 1.0857159627596 4.94471062546756e-24 -0.0987969676790623 0.559050375624812 miRNATAP -0.151352324882194 0.00401003633166406 NA NA NA hsa-miR-374b-5p WNT5A -0.466781429946153 1.17238311619116e-08 -0.0987969676790623 0.559050375624812 MirTarget;miRNATAP -0.20398183143879 0.00391173355873326 NA NA NA hsa-miR-576-5p WNT5A 0.0649387707567879 0.588791966096287 -0.0987969676790623 0.559050375624812 mirMAP -0.219900857430154 5.01514505641987e-06 NA NA NA hsa-miR-590-3p WNT5A 1.27438512890514 1.03164723481469e-23 -0.0987969676790623 0.559050375624812 miRanda;mirMAP;miRNATAP -0.276206250056969 2.00878373474974e-09 NA NA NA hsa-miR-7-1-3p WNT5A 0.686579567507582 1.20731554448806e-07 -0.0987969676790623 0.559050375624812 mirMAP -0.228321533184529 2.31205663077237e-07 NA NA NA hsa-miR-92a-3p WNT5A -0.342420481092807 0.000732275969501111 -0.0987969676790623 0.559050375624812 miRNAWalker2_validate -0.456191278985706 5.11502285589708e-16 NA NA NA hsa-miR-339-5p WNT5B -0.211548290465418 0.0685885445822389 -0.676281807762083 1.11957729947182e-05 miRanda -0.185095344713092 5.01294231609421e-05 NA NA NA hsa-miR-10b-5p WNT7B -2.10996264627796 7.36811595736367e-72 2.29617242327329 2.05565381147612e-26 mirMAP -0.19739104901179 0.00088619253374349 NA NA NA hsa-miR-30a-5p WNT7B -0.392489994825279 0.00954894667761676 2.29617242327329 2.05565381147612e-26 miRNATAP -0.244710473588963 1.09537488646518e-06 NA NA NA hsa-miR-30b-3p WNT7B -0.536462824497982 2.41814659272548e-05 2.29617242327329 2.05565381147612e-26 MirTarget;mirMAP -0.199927265231065 0.000916083804937799 NA NA NA hsa-miR-30c-5p WNT7B -0.393222674580066 8.06961465717306e-05 2.29617242327329 2.05565381147612e-26 miRNATAP -0.455544291260138 2.11209121770824e-09 NA NA NA hsa-miR-326 WNT7B -1.54449030848141 1.04703417845594e-17 2.29617242327329 2.05565381147612e-26 MirTarget;miRanda -0.161789035877396 9.64577721935033e-05 NA NA NA hsa-miR-335-5p WNT7B -2.61355235628987 2.6462884165886e-51 2.29617242327329 2.05565381147612e-26 miRNAWalker2_validate -0.23895557225465 6.17708068119425e-09 NA NA NA hsa-miR-491-5p WNT7B -1.04307210952796 1.14586501470398e-15 2.29617242327329 2.05565381147612e-26 mirMAP -0.270664526249752 2.96434624276917e-06 NA NA NA hsa-miR-505-3p WNT7B -0.530462599544864 7.71645736541597e-05 2.29617242327329 2.05565381147612e-26 miRNATAP -0.25367826265264 7.46180280225906e-06 NA NA NA hsa-miR-1271-5p WNT9A -1.08290983583835 3.85149976357318e-12 0.447765230183606 0.0124427267373267 mirMAP -0.151077426632908 0.000116310190119482 NA NA NA hsa-miR-148a-3p WNT9A 0.706969798912638 5.52538085480485e-09 0.447765230183606 0.0124427267373267 mirMAP -0.298084226700717 2.38424942045375e-09 NA NA NA hsa-miR-148b-3p WNT9A 1.0552576751879 1.6679285705231e-29 0.447765230183606 0.0124427267373267 mirMAP -0.216690484061052 0.000659770444792974 NA NA NA hsa-miR-15b-5p WNT9A 0.788659356634696 1.13678211092534e-11 0.447765230183606 0.0124427267373267 mirMAP -0.160780744423949 0.00213391068310254 NA NA NA hsa-miR-16-5p WNT9A 0.46835991343556 1.91125356547776e-06 0.447765230183606 0.0124427267373267 mirMAP -0.294351524109689 2.19404233093207e-06 NA NA NA hsa-miR-181a-2-3p WNT9A -0.0718643470098321 0.422077954889554 0.447765230183606 0.0124427267373267 mirMAP -0.200099377422022 0.00380063581033883 NA NA NA hsa-miR-193a-3p WNT9A 0.310617999804917 0.00477640270974957 0.447765230183606 0.0124427267373267 mirMAP -0.305391600401298 3.90157370096497e-08 NA NA NA hsa-miR-195-5p WNT9A -1.47508108420708 2.20685847368258e-38 0.447765230183606 0.0124427267373267 mirMAP -0.196363300820022 0.000137496059895827 NA NA NA hsa-miR-28-5p WNT9A -0.14267073663385 0.0497619246260571 0.447765230183606 0.0124427267373267 mirMAP -0.292797790744078 0.000600350405048975 NA NA NA hsa-miR-32-5p WNT9A 1.38676603945192 2.29428299685976e-34 0.447765230183606 0.0124427267373267 mirMAP -0.216445530743276 3.06978747423399e-05 NA NA NA hsa-miR-331-3p WNT9A 0.74441480542886 1.17071235477799e-07 0.447765230183606 0.0124427267373267 mirMAP -0.137832471681534 0.00151040501960236 NA NA NA hsa-miR-335-5p WNT9A -2.61355235628987 2.6462884165886e-51 0.447765230183606 0.0124427267373267 miRNAWalker2_validate -0.146714794864289 9.92998698360538e-06 NA NA NA hsa-miR-363-3p WNT9A -0.0402062060863897 0.833024617256265 0.447765230183606 0.0124427267373267 mirMAP -0.126772985407334 8.48022074883423e-05 NA NA NA hsa-miR-424-5p WNT9A 0.420789584199235 0.00480101660479489 0.447765230183606 0.0124427267373267 mirMAP -0.203387678407749 6.84865574984046e-07 NA NA NA hsa-miR-497-5p WNT9A -1.4667331575679 5.49909921822638e-36 0.447765230183606 0.0124427267373267 mirMAP -0.228181412286226 5.31377710156938e-06 NA NA NA hsa-miR-532-3p WNT9A -0.395473145042459 0.00686714288452761 0.447765230183606 0.0124427267373267 mirMAP -0.144881932218838 0.000552241596034881 NA NA NA hsa-miR-708-5p WNT9A 0.638386255192461 1.19735143565146e-06 0.447765230183606 0.0124427267373267 mirMAP -0.12045189873946 0.00968711444884768 NA NA NA hsa-miR-141-3p WTIP 2.99777540204168 1.26370498493024e-78 -0.673697271502645 8.0399213972999e-08 mirMAP -0.225708945128347 5.44689065635373e-21 NA NA NA hsa-miR-15b-5p WTIP 0.788659356634696 1.13678211092534e-11 -0.673697271502645 8.0399213972999e-08 mirMAP -0.177847555758502 1.3187974063905e-06 NA NA NA hsa-miR-16-5p WTIP 0.46835991343556 1.91125356547776e-06 -0.673697271502645 8.0399213972999e-08 mirMAP -0.383737049699171 5.59549877182793e-19 NA NA NA hsa-miR-183-5p WTIP 2.95681814393872 1.09965777344285e-92 -0.673697271502645 8.0399213972999e-08 mirMAP -0.233303798414219 3.87335814437078e-19 NA NA NA hsa-miR-186-5p WTIP -0.426987301460247 1.04129380549315e-05 -0.673697271502645 8.0399213972999e-08 mirMAP -0.243621440903983 4.28179034379265e-08 NA NA NA hsa-miR-193a-3p WTIP 0.310617999804917 0.00477640270974957 -0.673697271502645 8.0399213972999e-08 mirMAP -0.229486321880911 4.54802470753392e-09 NA NA NA hsa-miR-193b-3p WTIP -0.0550374855074773 0.65382485898551 -0.673697271502645 8.0399213972999e-08 mirMAP -0.22428705020864 1.62549485885399e-10 NA NA NA hsa-miR-193b-5p WTIP -0.481487407783336 0.000206895781789619 -0.673697271502645 8.0399213972999e-08 mirMAP -0.16076226989485 1.32683530745167e-06 NA NA NA hsa-miR-197-3p WTIP -0.526589453596294 3.61594599437195e-06 -0.673697271502645 8.0399213972999e-08 mirMAP -0.124466217405725 0.00105603522153809 NA NA NA hsa-miR-200a-3p WTIP 2.55218480823434 2.96135446816238e-51 -0.673697271502645 8.0399213972999e-08 mirMAP -0.153578019023446 1.2728190646307e-10 NA NA NA hsa-miR-20a-3p WTIP -0.218902047543766 0.179868363625547 -0.673697271502645 8.0399213972999e-08 mirMAP -0.11494559612801 1.52131128027358e-05 NA NA NA hsa-miR-29b-3p WTIP 0.438847962603729 6.46722433236121e-05 -0.673697271502645 8.0399213972999e-08 mirMAP -0.287309336850424 1.52019391963535e-13 NA NA NA hsa-miR-29c-3p WTIP -0.0652732378039769 0.563774115756922 -0.673697271502645 8.0399213972999e-08 mirMAP -0.123564940413865 0.00131090719522803 NA NA NA hsa-miR-32-5p WTIP 1.38676603945192 2.29428299685976e-34 -0.673697271502645 8.0399213972999e-08 mirMAP -0.198568801097127 5.26292566020015e-08 NA NA NA hsa-miR-324-3p WTIP 0.404877731996915 0.000340036423920834 -0.673697271502645 8.0399213972999e-08 mirMAP -0.245219699827983 1.07117992919804e-10 NA NA NA hsa-miR-324-5p WTIP 0.211552647440779 0.139408130311654 -0.673697271502645 8.0399213972999e-08 mirMAP -0.138447416758342 4.5613050337777e-06 NA NA NA hsa-miR-326 WTIP -1.54449030848141 1.04703417845594e-17 -0.673697271502645 8.0399213972999e-08 mirMAP -0.17202714995249 1.39970444469099e-13 NA NA NA hsa-miR-330-5p WTIP 0.626063225953928 3.42215028606779e-09 -0.673697271502645 8.0399213972999e-08 mirMAP -0.266996987951299 3.30125395872707e-11 NA NA NA hsa-miR-331-3p WTIP 0.74441480542886 1.17071235477799e-07 -0.673697271502645 8.0399213972999e-08 mirMAP -0.331800260525477 3.99834689422666e-29 NA NA NA hsa-miR-342-5p WTIP 1.49554286219821 1.56221300255782e-22 -0.673697271502645 8.0399213972999e-08 mirMAP -0.232011295425814 9.51175174396452e-18 NA NA NA hsa-miR-34a-5p WTIP 0.129201805242403 0.133261654068224 -0.673697271502645 8.0399213972999e-08 mirMAP -0.131580463765731 0.00952351345758211 NA NA NA hsa-miR-425-5p WTIP 0.719898949241718 6.01079610190374e-08 -0.673697271502645 8.0399213972999e-08 mirMAP -0.199210356160852 5.6482163530293e-10 NA NA NA hsa-miR-484 WTIP 0.349444060004737 0.00154491249625173 -0.673697271502645 8.0399213972999e-08 mirMAP -0.302861968535349 5.10857823967367e-15 NA NA NA hsa-miR-550a-5p WTIP -0.12364998419382 0.410467966112492 -0.673697271502645 8.0399213972999e-08 mirMAP -0.134997831546667 4.29438728678462e-06 NA NA NA hsa-miR-582-3p WTIP 0.126152488945932 0.333088461939587 -0.673697271502645 8.0399213972999e-08 mirMAP -0.122439530922553 0.000233787125332097 NA NA NA hsa-miR-625-5p WTIP 0.728939236913178 5.97591217674307e-08 -0.673697271502645 8.0399213972999e-08 mirMAP -0.280594797824602 4.98654999947647e-18 NA NA NA hsa-miR-92b-3p WTIP 1.30248132773644 9.42428674470985e-25 -0.673697271502645 8.0399213972999e-08 mirMAP -0.137073474318649 3.54560697393122e-05 NA NA NA hsa-miR-1-3p WWC1 -1.92761220689044 2.14541307073875e-29 0.46987531678564 1.37239256195461e-05 MirTarget -0.155094424083891 9.55693834888184e-14 NA NA NA hsa-miR-15a-5p WWC1 0.812445324157528 4.50263417099822e-20 0.46987531678564 1.37239256195461e-05 MirTarget;miRNATAP -0.127856957315334 0.00193907517287061 NA NA NA hsa-miR-16-5p WWC1 0.46835991343556 1.91125356547776e-06 0.46987531678564 1.37239256195461e-05 MirTarget;miRNATAP -0.190763599166749 3.8524027834676e-07 NA NA NA hsa-miR-141-3p WWTR1 2.99777540204168 1.26370498493024e-78 -0.946157092633412 9.0126903364314e-15 MirTarget;TargetScan;miRNATAP -0.183547997043091 1.1010774322509e-14 NA NA NA hsa-miR-149-5p WWTR1 0.218233101703391 0.261629158371175 -0.946157092633412 9.0126903364314e-15 miRNATAP -0.167675360663874 6.91656852396393e-15 NA NA NA hsa-miR-193a-3p WWTR1 0.310617999804917 0.00477640270974957 -0.946157092633412 9.0126903364314e-15 miRanda -0.126747645091688 0.00104635017180811 NA NA NA hsa-miR-200a-3p WWTR1 2.55218480823434 2.96135446816238e-51 -0.946157092633412 9.0126903364314e-15 MirTarget;miRNATAP -0.182565021897447 4.59067387987806e-15 NA NA NA hsa-miR-29b-3p WWTR1 0.438847962603729 6.46722433236121e-05 -0.946157092633412 9.0126903364314e-15 miRNATAP -0.269878078203935 1.64654196457636e-12 NA NA NA hsa-miR-29c-3p WWTR1 -0.0652732378039769 0.563774115756922 -0.946157092633412 9.0126903364314e-15 miRNATAP -0.400443817589879 5.83476002820765e-28 NA NA NA hsa-miR-340-5p WWTR1 1.0857159627596 4.94471062546756e-24 -0.946157092633412 9.0126903364314e-15 mirMAP -0.160506606641614 3.08878446055469e-05 NA NA NA hsa-miR-3913-5p WWTR1 0.71890413546147 2.61153227160465e-13 -0.946157092633412 9.0126903364314e-15 mirMAP -0.204445198137282 1.69884371620961e-06 NA NA NA hsa-miR-664a-3p WWTR1 -0.237699857923843 0.0197071390183375 -0.946157092633412 9.0126903364314e-15 MirTarget;mirMAP -0.182876625503601 1.17154423780213e-05 NA NA NA hsa-miR-7-1-3p WWTR1 0.686579567507582 1.20731554448806e-07 -0.946157092633412 9.0126903364314e-15 mirMAP -0.136607156207421 2.63067537712004e-05 NA NA NA hsa-let-7a-3p YAP1 0.466622567891891 3.70886257943079e-07 -1.31738265371239 9.58372053397518e-43 mirMAP -0.121298300772523 0.00132438193344402 NA NA NA hsa-miR-141-3p YAP1 2.99777540204168 1.26370498493024e-78 -1.31738265371239 9.58372053397518e-43 MirTarget;TargetScan -0.224844503629252 1.84225185456191e-32 21289630 MicroRNA 141 confers resistance to cisplatin induced apoptosis by targeting YAP1 in human esophageal squamous cell carcinoma; Furthermore we found that miR-141 directly targeted the 3'-untranslated region of YAP1 which is known to have a crucial role in apoptosis induced by DNA-damaging agents and thus downregulated YAP1 expression drug resistance esophageal cancer hsa-miR-141-5p YAP1 2.38411349683216 4.56310582620282e-58 -1.31738265371239 9.58372053397518e-43 miRNATAP -0.208516538810642 8.25160642292028e-23 21289630 MicroRNA 141 confers resistance to cisplatin induced apoptosis by targeting YAP1 in human esophageal squamous cell carcinoma; Furthermore we found that miR-141 directly targeted the 3'-untranslated region of YAP1 which is known to have a crucial role in apoptosis induced by DNA-damaging agents and thus downregulated YAP1 expression drug resistance esophageal cancer hsa-miR-200a-3p YAP1 2.55218480823434 2.96135446816238e-51 -1.31738265371239 9.58372053397518e-43 miRNAWalker2_validate;MirTarget -0.179180498954883 2.18192480130206e-21 23340296 MicroRNA 200a promotes anoikis resistance and metastasis by targeting YAP1 in human breast cancer; We identified Yes-associated protein 1 YAP1 as a novel target of miR-200a; Our data showed that targeting of YAP1 by miR-200a resulted in decreased expression of proapoptotic proteins which leads to anoikis resistance; Remarkably we found that YAP1 expression was inversely correlated with miR-200a expression in breast cancer clinical specimens and miR-200a expression was associated with distant metastasis in patients with breast cancer metastasis;drug resistance breast cancer hsa-miR-200b-3p YAP1 2.11744072703209 1.66710572104191e-43 -1.31738265371239 9.58372053397518e-43 MirTarget -0.192196263932001 6.22401511406624e-20 NA NA NA hsa-miR-200c-3p YAP1 2.07038651806183 6.84613386286599e-51 -1.31738265371239 9.58372053397518e-43 MirTarget -0.246914816784172 4.26453849203752e-27 NA NA NA hsa-miR-21-5p YAP1 2.32007501846389 3.08394781855554e-137 -1.31738265371239 9.58372053397518e-43 MirTarget;miRNATAP -0.325756536921103 2.08121491758625e-26 NA NA NA hsa-miR-330-3p YAP1 0.432728362037032 0.00041335506960812 -1.31738265371239 9.58372053397518e-43 mirMAP -0.122598686996375 1.8554932994164e-05 NA NA NA hsa-miR-361-3p YAP1 -0.0370446538644886 0.624902392829872 -1.31738265371239 9.58372053397518e-43 MirTarget;PITA -0.184072233448736 6.83249288480317e-05 NA NA NA hsa-miR-361-5p YAP1 -0.0996867547900457 0.095428250126326 -1.31738265371239 9.58372053397518e-43 miRanda -0.207733379343817 0.000434293152589925 NA NA NA hsa-miR-375 YAP1 2.09893673049766 1.68351780396203e-16 -1.31738265371239 9.58372053397518e-43 miRNAWalker2_validate;miRTarBase;miRNATAP -0.120107822997014 3.96634849887855e-20 27270433;23685355;20226166;21856745 A ZEB1 miR 375 YAP1 pathway regulates epithelial plasticity in prostate cancer; The transcription factor YAP1 was found to be a direct target of miR-375 in prostate cancer; Knockdown of YAP1 phenocopied miR-375 overexpression and overexpression of YAP1 rescued anti-invasive effects mediated by miR-375;Overexpression of miR 10a and miR 375 and downregulation of YAP1 in medullary thyroid carcinoma; Expression of the potential downstream targets of miR-375 YAP1 a growth inhibitor and SLC16a2 a transporter of thyroid hormone was down-regulated in the tumors suggesting that miR-375 is a negative regulator of the expression of these genes; Furthermore the growth inhibitor YAP1 is identified as a potential important downstream target of miR-375;MicroRNA 375 targets Hippo signaling effector YAP in liver cancer and inhibits tumor properties; The present study aims to elucidate the transcriptional regulation of YAP targeted by microRNA miRNA miR-375 is a putative target and was found significantly down-regulated in the tumor versus adjacent non-tumor tissues of HCC patients n=48; As determined by luciferase reporter assay we found ectopic expression of miR-375 could diminish the transcriptional activity of YAP; Furthermore immunoblotting revealed miR-375 suppressed endogenous YAP protein level; miR-375 is an important regulator of YAP oncogene implicating a potential therapeutic role in HCC treatment;miR 375 is activated by ASH1 and inhibits YAP1 in a lineage dependent manner in lung cancer; The transcriptional coactivator YAP1 was determined to be a direct target of miR-375; YAP1 showed a negative correlation with miR-375 in a panel of lung cancer cell lines and growth inhibitory activities in NE-lung cancer cells ;;; prostate cancer;thyroid cancer;liver cancer;lung cancer hsa-miR-429 YAP1 2.84108892259147 3.88520896426515e-64 -1.31738265371239 9.58372053397518e-43 MirTarget;miRanda -0.173689900979646 2.12181225777702e-20 NA NA NA hsa-miR-590-3p YAP1 1.27438512890514 1.03164723481469e-23 -1.31738265371239 9.58372053397518e-43 miRanda;mirMAP -0.141942729467991 3.00070975523757e-07 NA NA NA hsa-miR-7-1-3p YAP1 0.686579567507582 1.20731554448806e-07 -1.31738265371239 9.58372053397518e-43 mirMAP -0.165986847649464 3.12128714709277e-10 NA NA NA hsa-miR-218-5p YWHAB -1.02621788318234 2.9221925445771e-23 0.367736029126437 1.14326902549126e-12 MirTarget;miRNATAP -0.118771072777071 1.2025708808827e-12 NA NA NA hsa-miR-361-5p YWHAB -0.0996867547900457 0.095428250126326 0.367736029126437 1.14326902549126e-12 MirTarget;PITA;miRanda;miRNATAP -0.129790382733719 1.94479562657361e-05 NA NA NA hsa-miR-26a-5p YWHAE -0.481180084102235 1.82368246174758e-10 0.0789078821698794 0.139244898488797 miRNAWalker2_validate;miRNATAP -0.139062156125765 6.21839958682607e-09 NA NA NA hsa-miR-181c-5p YWHAG 0.574847839298605 4.51287502066478e-07 -0.30496627096666 3.16855379814272e-06 MirTarget;miRNATAP -0.145586859940849 6.31211340218828e-14 NA NA NA hsa-miR-181d-5p YWHAG 0.782618466877349 1.2821116358212e-09 -0.30496627096666 3.16855379814272e-06 MirTarget -0.103217848799385 1.84401651957152e-09 NA NA NA hsa-miR-200b-3p YWHAG 2.11744072703209 1.66710572104191e-43 -0.30496627096666 3.16855379814272e-06 MirTarget;TargetScan -0.11952750278469 2.04909339347489e-18 NA NA NA hsa-miR-200c-3p YWHAG 2.07038651806183 6.84613386286599e-51 -0.30496627096666 3.16855379814272e-06 MirTarget;miRNATAP -0.115098762293347 2.44122702999837e-14 NA NA NA hsa-miR-30a-5p YWHAG -0.392489994825279 0.00954894667761676 -0.30496627096666 3.16855379814272e-06 miRNATAP -0.130408882982876 3.06189502357674e-19 NA NA NA hsa-miR-34c-3p YWHAG 0.213037310586265 0.144107566901292 -0.30496627096666 3.16855379814272e-06 MirTarget;PITA -0.101761318229923 6.09583697264274e-11 NA NA NA hsa-miR-361-3p YWHAG -0.0370446538644886 0.624902392829872 -0.30496627096666 3.16855379814272e-06 miRNATAP -0.123033020131908 3.98096255501155e-05 NA NA NA hsa-miR-195-5p YWHAH -1.47508108420708 2.20685847368258e-38 0.574547913335089 6.31677198141686e-23 MirTarget;miRNATAP -0.154571273062705 3.79154556881082e-20 NA NA NA hsa-miR-361-5p YWHAH -0.0996867547900457 0.095428250126326 0.574547913335089 6.31677198141686e-23 miRanda -0.122118229637353 0.00045156556380787 NA NA NA hsa-miR-497-5p YWHAH -1.4667331575679 5.49909921822638e-36 0.574547913335089 6.31677198141686e-23 MirTarget;miRNATAP -0.101887170785079 8.76599010415193e-10 NA NA NA hsa-miR-195-5p YWHAQ -1.47508108420708 2.20685847368258e-38 0.14614608366116 0.0210037506575042 MirTarget;miRNATAP -0.131078204286072 2.84212998538795e-13 NA NA NA hsa-let-7b-5p YWHAZ -0.54215483448257 7.21347617597858e-08 0.614503695418861 6.69168275891896e-13 miRNAWalker2_validate -0.143693415048529 9.14380074121916e-07 NA NA NA hsa-miR-140-3p YWHAZ -1.25844395244141 5.29222651039892e-33 0.614503695418861 6.69168275891896e-13 MirTarget;PITA;miRNATAP -0.220682872816636 1.53890225766904e-16 NA NA NA hsa-miR-195-3p YWHAZ -1.49582726452416 6.53261924105147e-40 0.614503695418861 6.69168275891896e-13 MirTarget -0.217318055382634 8.6510493117177e-19 NA NA NA hsa-miR-199a-5p YWHAZ -0.314703593105081 0.00909304983051124 0.614503695418861 6.69168275891896e-13 miRanda -0.142636123966747 5.50463507912081e-09 NA NA NA hsa-miR-199b-5p YWHAZ -1.37022396448377 3.25758057539223e-26 0.614503695418861 6.69168275891896e-13 miRanda -0.177217586869737 5.92745522971954e-16 NA NA NA hsa-miR-30a-5p YWHAZ -0.392489994825279 0.00954894667761676 0.614503695418861 6.69168275891896e-13 miRNAWalker2_validate;MirTarget;miRNATAP -0.183528380744408 8.33049950582494e-22 NA NA NA hsa-miR-34c-5p YWHAZ -0.0896438810345765 0.557016551646841 0.614503695418861 6.69168275891896e-13 miRanda -0.122122109832999 2.94590640777635e-10 NA NA NA hsa-miR-495-3p YWHAZ -1.67685437612894 1.70634429769052e-34 0.614503695418861 6.69168275891896e-13 mirMAP -0.129022570922436 4.47948910436123e-10 NA NA NA