miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-128-3p ABL1 0.98280381420517 5.77641850797209e-05 -0.962651345833518 7.23950193567278e-09 MirTarget -0.163562699793361 0.00096410618700775 NA NA NA hsa-miR-141-3p ABL1 1.45548825076434 0.00115958850961764 -0.962651345833518 7.23950193567278e-09 MirTarget -0.186139786843855 2.57511874966351e-13 NA NA NA hsa-miR-142-5p ABL1 1.55592486377018 6.69269968016779e-06 -0.962651345833518 7.23950193567278e-09 MirTarget -0.17367110583317 2.89817954365468e-07 NA NA NA hsa-miR-15b-3p ABL1 1.75738933306437 3.00554466232543e-08 -0.962651345833518 7.23950193567278e-09 MirTarget -0.15157398070684 4.00456618892552e-05 NA NA NA hsa-miR-15b-5p ABL1 1.62046407540723 5.42152621571078e-09 -0.962651345833518 7.23950193567278e-09 mirMAP -0.196565551881613 2.59795461494049e-06 NA NA NA hsa-miR-16-5p ABL1 1.00515772948091 5.33912942007619e-06 -0.962651345833518 7.23950193567278e-09 mirMAP -0.283118977596646 1.253060404789e-07 NA NA NA hsa-miR-19a-3p ABL1 1.26669687448473 0.000105972838514412 -0.962651345833518 7.23950193567278e-09 mirMAP -0.156990735722488 1.6421639310259e-05 NA NA NA hsa-miR-200a-3p ABL1 0.717826667295984 0.193912116506827 -0.962651345833518 7.23950193567278e-09 MirTarget -0.123971838305621 6.33875256738154e-09 NA NA NA hsa-miR-29a-5p ABL1 0.585084040404152 0.023014129158495 -0.962651345833518 7.23950193567278e-09 MirTarget -0.126437521845138 0.00826584797822056 NA NA NA hsa-miR-30b-5p ABL1 -0.430720743745757 0.0593564057320791 -0.962651345833518 7.23950193567278e-09 MirTarget;miRNATAP -0.143381643266005 0.00830489235379627 NA NA NA hsa-miR-30e-5p ABL1 -0.573784818166736 0.0112497802572927 -0.962651345833518 7.23950193567278e-09 MirTarget;miRNATAP -0.145019804823193 0.00794227636205602 NA NA NA hsa-miR-330-5p ABL1 0.488365986827708 0.0512207630808233 -0.962651345833518 7.23950193567278e-09 MirTarget -0.242931653509721 4.59623710204268e-07 NA NA NA hsa-miR-423-5p ABL1 0.832613878736338 0.000791321227103338 -0.962651345833518 7.23950193567278e-09 MirTarget -0.149057687668797 0.00244756506789077 NA NA NA hsa-miR-484 ABL1 0.71327898984355 0.00233605130771196 -0.962651345833518 7.23950193567278e-09 miRNAWalker2_validate -0.260870463943224 3.55629586858196e-07 NA NA NA hsa-miR-503-5p ABL1 1.88558728489534 2.26317868368257e-06 -0.962651345833518 7.23950193567278e-09 mirMAP -0.103276345406703 0.000511388601881552 NA NA NA hsa-miR-30a-3p ANAPC10 -1.73205137750899 3.2425754511091e-07 0.446111212226183 0.00577333514035222 MirTarget;miRNATAP -0.128671131445565 7.94548927453185e-05 NA NA NA hsa-miR-139-5p ANAPC7 -1.83374360776637 1.22019901002824e-09 0.582775453353822 0.000365164263536601 miRanda -0.103856702409456 0.00534807983668829 NA NA NA hsa-miR-30c-2-3p ANAPC7 -1.13954984520886 0.000846438233267901 0.582775453353822 0.000365164263536601 MirTarget -0.117885992176576 0.000478985598826551 NA NA NA hsa-miR-125a-3p ATM 1.19506542853853 0.00164364545717311 -0.394769053567885 0.0834135681853264 miRanda -0.132495092210333 0.00187961461837904 NA NA NA hsa-miR-203a-3p ATM 1.44736908507496 0.0394116388736904 -0.394769053567885 0.0834135681853264 MirTarget -0.138506783210379 2.82519981053352e-10 24145123;27542403 miR 203 induces oxaliplatin resistance in colorectal cancer cells by negatively regulating ATM kinase; In silico analysis identified ataxia telangiectasia mutated ATM a primary mediator of the DNA damage response as a potential target of miR-203; Using TCGA database we identified a significant reverse correlation of miR-203 and ATM expression in CRC tissues; We validated ATM as a bona fide target of miR-203 in CRC cells; Mutation of the putative miR-203 binding site in the 3' untranslated region 3'UTR of the ATM mRNA abolished the inhibitory effect of miR-203 on ATM;MiR 203 inhibits tumor invasion and metastasis in gastric cancer by ATM; Our results showed that miR-203 was significantly downregulated in gastric cancer tissues and cells while ataxia telangiectasia mutated kinase ATM was upregulated in gastric cancer tissues and cells and was directly regulated by miR-203; ATM knockdown phenocopied the effect of miR-203 overexpression drug resistance;metastasis colorectal cancer;gastric cancer hsa-miR-590-5p ATM 1.04171442093217 0.000272475544954865 -0.394769053567885 0.0834135681853264 mirMAP -0.169733213019369 0.00247037314325533 NA NA NA hsa-miR-30b-5p ATR -0.430720743745757 0.0593564057320791 0.73072161730785 0.000167590638966927 mirMAP -0.185879461945995 0.0026504272804509 NA NA NA hsa-miR-139-5p BUB1 -1.83374360776637 1.22019901002824e-09 3.99218972163818 7.88952552974525e-32 miRanda -0.519278696326487 3.4160581869935e-09 NA NA NA hsa-miR-139-5p BUB3 -1.83374360776637 1.22019901002824e-09 0.879304323303634 8.00919764853413e-10 miRanda -0.16283201907168 7.32304381927293e-07 NA NA NA hsa-miR-107 CCNA1 0.904627575346218 4.67936495073904e-05 1.84631355917681 0.166439100989345 miRanda -2.10593675951345 4.6233202005442e-07 NA NA NA hsa-miR-30a-5p CCNA1 -1.71922855140016 3.20574349285256e-07 1.84631355917681 0.166439100989345 MirTarget -0.877059096773171 0.00138709429376332 NA NA NA hsa-miR-30b-5p CCNA1 -0.430720743745757 0.0593564057320791 1.84631355917681 0.166439100989345 MirTarget -1.24375172760432 0.00318823232308493 NA NA NA hsa-miR-30d-5p CCNA1 -0.5492586056147 0.0140125082460125 1.84631355917681 0.166439100989345 MirTarget -2.13046806002748 4.12147570687155e-07 NA NA NA hsa-miR-335-5p CCNA1 1.59953351087307 5.56170899867314e-05 1.84631355917681 0.166439100989345 miRNAWalker2_validate -1.04873582016328 6.01047506929633e-06 NA NA NA hsa-miR-129-5p CCNA2 -2.56914016541176 2.36237896095709e-06 2.90090608143828 4.79629041224721e-23 miRanda -0.168329474978999 6.76153571387745e-05 NA NA NA hsa-miR-218-5p CCNA2 -0.987730614742492 0.0108295837207062 2.90090608143828 4.79629041224721e-23 MirTarget -0.159126174406476 0.00835887840389226 NA NA NA hsa-miR-29c-3p CCNA2 -1.62454036584589 5.38376515586029e-07 2.90090608143828 4.79629041224721e-23 MirTarget -0.436969249965464 1.04760562655809e-10 NA NA NA hsa-miR-139-5p CCNB1 -1.83374360776637 1.22019901002824e-09 2.86029513012046 1.09631454385186e-20 miRanda -0.494002119509298 2.06388587911453e-11 NA NA NA hsa-miR-338-3p CCND1 -0.959276231066179 0.0191473351014091 0.62464034212269 0.131198685408586 miRNAWalker2_validate;miRTarBase;miRanda -0.237799286777961 0.000859583563159798 NA NA NA hsa-let-7a-3p CCND2 0.503048155002889 0.0411145454335299 -0.495732246530821 0.299995013548082 mirMAP -0.539007488034469 9.58303749078928e-05 20418948 MicroRNA let 7a inhibits proliferation of human prostate cancer cells in vitro and in vivo by targeting E2F2 and CCND2 prostate cancer hsa-let-7b-3p CCND2 0.21838629112113 0.296038413622566 -0.495732246530821 0.299995013548082 mirMAP -0.458425126620734 0.00587678366196967 NA NA NA hsa-miR-106b-5p CCND2 1.70863907461894 2.04074794107142e-08 -0.495732246530821 0.299995013548082 miRNAWalker2_validate;miRTarBase;miRNATAP -0.420111135029172 8.79445971678554e-05 NA NA NA hsa-miR-130b-5p CCND2 0.701350393759937 0.0510142718395002 -0.495732246530821 0.299995013548082 mirMAP -0.393986053261913 2.48361314637284e-05 NA NA NA hsa-miR-141-3p CCND2 1.45548825076434 0.00115958850961764 -0.495732246530821 0.299995013548082 MirTarget;TargetScan -0.213829265059233 0.00435932519246045 NA NA NA hsa-miR-15b-5p CCND2 1.62046407540723 5.42152621571078e-09 -0.495732246530821 0.299995013548082 miRNATAP -0.436574112059407 0.000206222006606723 NA NA NA hsa-miR-16-2-3p CCND2 1.8048179609245 2.83095715136409e-09 -0.495732246530821 0.299995013548082 mirMAP -0.54923627359894 1.83952504317926e-07 NA NA NA hsa-miR-16-5p CCND2 1.00515772948091 5.33912942007619e-06 -0.495732246530821 0.299995013548082 miRNAWalker2_validate;miRNATAP -0.666404634405191 9.74095569654959e-06 NA NA NA hsa-miR-181a-2-3p CCND2 0.901732254836667 0.000830304681396734 -0.495732246530821 0.299995013548082 mirMAP -0.381747755391939 0.00236274066260059 NA NA NA hsa-miR-182-5p CCND2 0.887369486030646 0.0310640781418789 -0.495732246530821 0.299995013548082 miRNAWalker2_validate;miRTarBase;miRNATAP -0.320494097434122 8.56279904949731e-05 NA NA NA hsa-miR-183-5p CCND2 1.65900927871187 0.000522025364980187 -0.495732246530821 0.299995013548082 miRNATAP -0.293018901580787 2.29962975856133e-05 NA NA NA hsa-miR-19b-3p CCND2 0.759818275708988 0.00652779573186786 -0.495732246530821 0.299995013548082 miRNAWalker2_validate;MirTarget;miRNATAP -0.321137891620492 0.0085283453454723 NA NA NA hsa-miR-21-3p CCND2 1.75245546017565 2.36505176715025e-10 -0.495732246530821 0.299995013548082 mirMAP -0.330852598235875 0.00510140773909108 NA NA NA hsa-miR-224-3p CCND2 1.52422171450716 0.00650463542340912 -0.495732246530821 0.299995013548082 mirMAP -0.268591207673576 3.7771965471366e-05 NA NA NA hsa-miR-26b-5p CCND2 -0.301646326928219 0.160081421968103 -0.495732246530821 0.299995013548082 mirMAP;miRNATAP -0.575426727790569 0.00033543015515606 NA NA NA hsa-miR-301a-3p CCND2 1.44721900431161 6.35068481036652e-06 -0.495732246530821 0.299995013548082 miRNAWalker2_validate -0.383757128016972 0.0002041077399091 NA NA NA hsa-miR-3065-3p CCND2 -1.03551124329864 0.0218397494946288 -0.495732246530821 0.299995013548082 MirTarget;miRNATAP -0.202763155868079 0.00685463393219998 NA NA NA hsa-miR-3065-5p CCND2 -0.241623656423063 0.633116553078159 -0.495732246530821 0.299995013548082 mirMAP -0.236172852888811 0.000570437819651464 NA NA NA hsa-miR-424-5p CCND2 1.08509868581983 0.000420473853818268 -0.495732246530821 0.299995013548082 miRNATAP -0.393741408465626 0.000302491529945387 NA NA NA hsa-miR-429 CCND2 1.40182602301928 0.00900426780286475 -0.495732246530821 0.299995013548082 miRNATAP -0.193697975832347 0.00200087926732012 NA NA NA hsa-miR-450b-5p CCND2 0.46157963033014 0.13273722727895 -0.495732246530821 0.299995013548082 MirTarget;PITA;miRNATAP -0.319300360536976 0.00413356428949538 NA NA NA hsa-miR-590-3p CCND2 1.11654983899947 0.000160782154924864 -0.495732246530821 0.299995013548082 miRanda;mirMAP -0.332566390160307 0.00348233876262983 NA NA NA hsa-miR-590-5p CCND2 1.04171442093217 0.000272475544954865 -0.495732246530821 0.299995013548082 mirMAP -0.40586994965179 0.000547583893303904 NA NA NA hsa-miR-9-3p CCND2 0.330346058941473 0.541111939982661 -0.495732246530821 0.299995013548082 MirTarget;mirMAP;miRNATAP -0.190791407012111 0.00360684983294818 NA NA NA hsa-miR-93-5p CCND2 1.7515174434778 1.59386482413883e-08 -0.495732246530821 0.299995013548082 miRNATAP -0.321341054229317 0.00244079386586045 NA NA NA hsa-miR-96-5p CCND2 1.14243043653372 0.00942969392739105 -0.495732246530821 0.299995013548082 TargetScan;miRNATAP -0.334672732851839 2.58915737933556e-05 NA NA NA hsa-miR-96-5p CCND3 1.14243043653372 0.00942969392739105 0.0356607593991125 0.883520357560836 TargetScan -0.119818202566509 0.00327749541512401 NA NA NA hsa-miR-125b-5p CCNE1 -0.509303501421334 0.133265526313161 2.19321666957752 7.58574979891593e-09 miRNAWalker2_validate -0.26234320685223 0.00155046398906082 NA NA NA hsa-miR-195-5p CCNE1 -0.907998841926297 0.00150511564650591 2.19321666957752 7.58574979891593e-09 miRNAWalker2_validate;MirTarget;miRNATAP -0.431213874492418 7.80520066718325e-06 24402230 Furthermore through qPCR and western blot assays we showed that overexpression of miR-195-5p reduced CCNE1 mRNA and protein levels respectively breast cancer hsa-miR-497-5p CCNE1 -0.801030912431774 0.00360386743876612 2.19321666957752 7.58574979891593e-09 MirTarget;miRNATAP -0.428398960662757 2.16247264707644e-05 24112607;25909221;24909281 Western blot assays confirmed that overexpression of miR-497 reduced cyclin E1 protein levels; Inhibited cellular growth suppressed cellular migration and invasion and G1 cell cycle arrest were observed upon overexpression of miR-497 in cells possibly by targeting cyclin E1;The effect of simultaneous overexpression of miR-497 and miR-34a on the inhibition of cell proliferation colony formation and tumor growth and the downregulation of cyclin E1 was stronger than the effect of each miRNA alone; The synergistic actions of miR-497 and miR-34a partly correlated with cyclin E1 levels; These results indicate cyclin E1 is downregulated by both miR-497 and miR-34a which synergistically retard the growth of human lung cancer cells;miR 497 suppresses proliferation of human cervical carcinoma HeLa cells by targeting cyclin E1; Furthermore the target effect of miR-497 on the CCNE1 was identified by dual-luciferase reporter assay system qRT-PCR and Western blotting; Over-expressed miR-497 in HeLa cells could suppress cell proliferation by targeting CCNE1 ;; breast cancer;lung cancer;cervical and endocervical cancer hsa-miR-26a-5p CCNE2 -0.384110714440647 0.0442498636014044 1.35587893076287 2.63917326776567e-06 miRNAWalker2_validate;miRTarBase;miRNATAP -0.435562646712902 9.72974519873178e-05 24116110;21901171 The loss of miR 26a mediated post transcriptional regulation of cyclin E2 in pancreatic cancer cell proliferation and decreased patient survival; The in vitro and in vivo assays showed that overexpression of miR-26a resulted in cell cycle arrest inhibited cell proliferation and decreased tumor growth which was associated with cyclin E2 downregulation;We also show that enforced expression of miR-26a in AML cells is able to inhibit cell cycle progression by downregulating cyclin E2 expression poor survival;progression pancreatic cancer;acute myeloid leukemia hsa-miR-30a-5p CCNE2 -1.71922855140016 3.20574349285256e-07 1.35587893076287 2.63917326776567e-06 miRNATAP -0.216731893468082 0.000339344793439292 NA NA NA hsa-miR-23b-3p CCNH -0.286465516491361 0.18664668472995 -0.1750114889018 0.230960386047907 MirTarget -0.176454913520335 0.000226975951697256 NA NA NA hsa-let-7a-3p CDC14A 0.503048155002889 0.0411145454335299 -0.721221707955118 0.00570358327676208 mirMAP -0.249720422915874 0.00105094642293619 NA NA NA hsa-let-7b-3p CDC14A 0.21838629112113 0.296038413622566 -0.721221707955118 0.00570358327676208 mirMAP -0.404323797375623 6.70864576551628e-06 NA NA NA hsa-let-7f-1-3p CDC14A 1.28704406797397 1.17954701106157e-06 -0.721221707955118 0.00570358327676208 mirMAP -0.276514469274122 5.33179218951831e-05 NA NA NA hsa-let-7a-3p CDC14B 0.503048155002889 0.0411145454335299 -0.808682779858277 0.00842928311839816 miRNATAP -0.371154768873371 3.00219055988735e-05 NA NA NA hsa-let-7b-3p CDC14B 0.21838629112113 0.296038413622566 -0.808682779858277 0.00842928311839816 miRNATAP -0.362263138566124 0.000700452555910662 NA NA NA hsa-miR-193a-5p CDC14B 0.0732367916509009 0.76855333807308 -0.808682779858277 0.00842928311839816 miRNATAP -0.467182064007952 8.40742271998716e-08 NA NA NA hsa-miR-27a-3p CDC14B 1.29886998470345 2.68986118553486e-08 -0.808682779858277 0.00842928311839816 miRNATAP -0.54883885772967 5.27642383253964e-10 NA NA NA hsa-miR-27b-3p CDC14B 0.0836323965901755 0.725273923274 -0.808682779858277 0.00842928311839816 miRNATAP -0.403750397387189 1.26483862927864e-05 NA NA NA hsa-miR-944 CDC14B 3.33123095809751 0.0177835044930391 -0.808682779858277 0.00842928311839816 PITA;mirMAP;miRNATAP -0.139173498077877 4.24476441259956e-16 NA NA NA hsa-miR-30a-5p CDC20 -1.71922855140016 3.20574349285256e-07 3.92236383515012 3.50298891240934e-28 miRNAWalker2_validate -0.481207939960431 4.40051543584442e-09 NA NA NA hsa-miR-29c-3p CDC23 -1.62454036584589 5.38376515586029e-07 0.351161254316074 0.0105321803141334 miRNAWalker2_validate -0.138932728708602 1.15724511791642e-06 NA NA NA hsa-let-7c-5p CDC25A -0.503482361446512 0.206848395212976 2.068940004277 2.82432654163725e-11 MirTarget -0.206351531201104 0.000387656338132804 25909324 MicroRNA let 7c Inhibits Cell Proliferation and Induces Cell Cycle Arrest by Targeting CDC25A in Human Hepatocellular Carcinoma; The aim of the present study was to determine whether the cell cycle regulator CDC25A is involved in the antitumor effect of let-7c in HCC; The luciferase reporter assay showed that CDC25A was a direct target of let-7c and that let-7c inhibited the expression of CDC25A protein by directly targeting its 3' UTR; In conclusion this study indicates that let-7c suppresses HCC progression possibly by directly targeting the cell cycle regulator CDC25A and indirectly affecting its downstream target molecules progression liver cancer hsa-miR-195-5p CDC25A -0.907998841926297 0.00150511564650591 2.068940004277 2.82432654163725e-11 MirTarget;miRNATAP -0.374976148413088 2.60248249580077e-06 NA NA NA hsa-miR-497-5p CDC25A -0.801030912431774 0.00360386743876612 2.068940004277 2.82432654163725e-11 MirTarget;miRNATAP -0.391957703078537 2.46948613315265e-06 NA NA NA hsa-miR-148a-3p CDC25B -1.53721533763578 3.55533747293117e-05 2.46035095515554 2.56407253133031e-15 miRNAWalker2_validate;miRNATAP -0.190871502462654 0.0024238869617265 25341915 Gene CDC25B might be the target gene of miR-148a according to the results of targetscan; CDC25B may be the target gene of miR-148a that plays a role in tumor suppressor gastric cancer hsa-miR-107 CDC27 0.904627575346218 4.67936495073904e-05 0.381490105415248 0.0058031749684071 miRanda;miRNATAP -0.150696301445594 0.000562471430191626 NA NA NA hsa-miR-195-5p CDC27 -0.907998841926297 0.00150511564650591 0.381490105415248 0.0058031749684071 miRNATAP -0.218349532619632 1.84145005232972e-11 NA NA NA hsa-miR-32-5p CDC27 0.415247682945382 0.106458022460373 0.381490105415248 0.0058031749684071 miRNAWalker2_validate -0.153379816763167 5.40355506509631e-05 NA NA NA hsa-miR-326 CDC27 -0.429748586406214 0.2629894124021 0.381490105415248 0.0058031749684071 miRanda -0.123019933410362 1.14187443038481e-06 NA NA NA hsa-miR-335-5p CDC27 1.59953351087307 5.56170899867314e-05 0.381490105415248 0.0058031749684071 miRNATAP -0.104706156688917 1.1394124379561e-05 NA NA NA hsa-miR-497-5p CDC27 -0.801030912431774 0.00360386743876612 0.381490105415248 0.0058031749684071 miRNATAP -0.155792864201933 8.54999590352517e-06 NA NA NA hsa-miR-338-5p CDC7 -1.19659203838734 0.0100316010080496 1.74978506756594 7.11977815132759e-12 mirMAP -0.158384620656881 9.51396893897648e-05 NA NA NA hsa-miR-145-5p CDK4 -1.75133578902314 1.54965572197748e-05 1.15953651250859 6.32013674437628e-08 miRNAWalker2_validate;miRTarBase -0.128867203591511 0.00065492290615456 21092188 Furthermore we found that CDK4 was regulated by miR-145 in cell cycle control lung squamous cell cancer hsa-miR-195-5p CDK4 -0.907998841926297 0.00150511564650591 1.15953651250859 6.32013674437628e-08 miRNAWalker2_validate;miRTarBase -0.160202666019046 0.00343668366819135 NA NA NA hsa-miR-101-3p CDK6 -0.451263906815861 0.0283387250173031 0.299248876757035 0.400797488709762 mirMAP -0.390880566201796 0.0017319791753036 NA NA NA hsa-miR-129-5p CDK6 -2.56914016541176 2.36237896095709e-06 0.299248876757035 0.400797488709762 miRNAWalker2_validate -0.131377486244208 0.00426734981945999 24055727 Interestingly we showed that cyclin dependent kinase 6 CDK6 a cell cycle-associated protein involved in G1-S transition was a target of miR-129 gastric cancer hsa-miR-30d-3p CDK6 -0.545113326540761 0.0433733076874155 0.299248876757035 0.400797488709762 mirMAP -0.279904118765617 0.00297854403213622 NA NA NA hsa-miR-30d-5p CDK6 -0.5492586056147 0.0140125082460125 0.299248876757035 0.400797488709762 mirMAP -0.442605862369401 9.48761181124052e-05 NA NA NA hsa-miR-139-5p CDK7 -1.83374360776637 1.22019901002824e-09 0.504422787455566 0.00793179421584655 miRanda -0.133736216293461 0.00188246166295244 NA NA NA hsa-miR-199a-5p CDK7 0.371973504507027 0.232661597228763 0.504422787455566 0.00793179421584655 miRanda -0.130720292024278 0.00270975068036262 NA NA NA hsa-let-7d-5p CDKN1A 0.981733854788227 7.26366577706469e-07 -0.527054376093461 0.0994835075201721 MirTarget -0.396477553702672 0.000479683524112273 NA NA NA hsa-let-7g-5p CDKN1A 0.325297685027927 0.241142963826631 -0.527054376093461 0.0994835075201721 MirTarget -0.314745562281535 0.000125688268144105 NA NA NA hsa-let-7i-5p CDKN1A 0.798954594465461 2.99735653959449e-05 -0.527054376093461 0.0994835075201721 MirTarget -0.322641868184451 0.00701233652117083 NA NA NA hsa-miR-101-3p CDKN1A -0.451263906815861 0.0283387250173031 -0.527054376093461 0.0994835075201721 MirTarget -0.447896067740702 5.80221830113762e-05 NA NA NA hsa-miR-106b-5p CDKN1A 1.70863907461894 2.04074794107142e-08 -0.527054376093461 0.0994835075201721 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.319691088785281 7.24575207668053e-06 NA NA NA hsa-miR-146a-5p CDKN1A 1.82051649415508 2.03651725047679e-05 -0.527054376093461 0.0994835075201721 miRNAWalker2_validate -0.181963416651094 0.000452608950605388 NA NA NA hsa-miR-17-5p CDKN1A 1.65862087862483 8.45603406215941e-08 -0.527054376093461 0.0994835075201721 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.261784540083651 0.000223281598813828 26482648;24989082 The low expressions of miR-17 and miR-92 families can maintain cisplatin resistance through the regulation of CDKN1A and RAD21;According to PicTar and Miranda algorithms which predicted CDKN1A p21 as a putative target of miR-17 a luciferase assay was performed and revealed that miR-17 directly targets the 3'-UTR of p21 mRNA drug resistance; lung squamous cell cancer;sarcoma hsa-miR-20a-5p CDKN1A 1.4503375861709 5.7813456424762e-07 -0.527054376093461 0.0994835075201721 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.31050980918024 4.24749867032784e-05 26012475 Using the poorly tumorigenic and TGF-β-sensitive FET cell line that expresses low miR-20a levels we first confirmed that miR-20a downmodulated CDKN1A expression both at mRNA and protein level through direct binding to its 3'-UTR; Moreover besides modulating CDKN1A miR-20a blocked TGF-β-induced transactivation of its promoter without affecting the post-receptor activation of Smad3/4 effectors directly; Finally miR-20a abrogated the TGF-β-mediated c-Myc repression a direct inhibitor of the CDKN1A promoter activation most likely by reducing the expression of specific MYC-regulating genes from the Smad/E2F-based core repressor complex colon cancer hsa-miR-30b-3p CDKN1A -0.266398938200332 0.400847813143994 -0.527054376093461 0.0994835075201721 MirTarget -0.232429451010355 0.00125169502954217 NA NA NA hsa-miR-335-5p CDKN1A 1.59953351087307 5.56170899867314e-05 -0.527054376093461 0.0994835075201721 miRNAWalker2_validate -0.323092043513641 2.937052662711e-09 NA NA NA hsa-miR-345-5p CDKN1A 1.83686164833727 1.1036889735857e-08 -0.527054376093461 0.0994835075201721 miRNAWalker2_validate;miRTarBase;MirTarget -0.244264832927155 0.000326167065691554 NA NA NA hsa-miR-423-3p CDKN1A 0.817576939524592 0.000261533454265696 -0.527054376093461 0.0994835075201721 miRNAWalker2_validate;miRTarBase -0.324900447056002 0.00137746661266851 NA NA NA hsa-miR-423-5p CDKN1A 0.832613878736338 0.000791321227103338 -0.527054376093461 0.0994835075201721 MirTarget -0.413612288167575 4.59123064989195e-06 NA NA NA hsa-miR-429 CDKN1A 1.40182602301928 0.00900426780286475 -0.527054376093461 0.0994835075201721 miRNATAP -0.134914410282826 0.00128436889666203 NA NA NA hsa-miR-93-5p CDKN1A 1.7515174434778 1.59386482413883e-08 -0.527054376093461 0.0994835075201721 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.319008304670668 5.03968506845812e-06 25633810 MicroRNA 93 activates c Met/PI3K/Akt pathway activity in hepatocellular carcinoma by directly inhibiting PTEN and CDKN1A; We confirmed that miR-93 directly bound with the 3' untranslated regions of the tumor-suppressor genes PTEN and CDKN1A respectivelyand inhibited their expression; We concluded that miR-93 stimulated cell proliferation migration and invasion through the oncogenic c-Met/PI3K/Akt pathway and also inhibited apoptosis by directly inhibiting PTEN and CDKN1A expression in human HCC liver cancer hsa-miR-942-5p CDKN1A 1.90585138008274 3.11903311044863e-09 -0.527054376093461 0.0994835075201721 miRNAWalker2_validate -0.183830567960007 0.00704444870897519 NA NA NA hsa-miR-24-3p CDKN1B 1.08578167539644 6.18549359075268e-07 0.155949085500731 0.363773087578399 miRNAWalker2_validate;miRNATAP -0.146430073571543 0.00772254700341091 26847530;26044523 The biological significance of miR-24 expression in prostate cancer cells was assessed by a series of in vitro bioassays and the effect on proposed targets p27 CDKN1B and p16 CDK2NA was investigated;With the bioinformatic method we further identified that p27Kip1 is a direct target of miR-24-3p and its protein level was negatively regulated by miR-24-3p ; prostate cancer;breast cancer hsa-miR-221-3p CDKN1C 1.33496247538338 3.82022531235275e-07 -1.64686390384498 2.97864022905914e-05 miRNAWalker2_validate;miRTarBase;miRNATAP -0.322791823347232 0.00244107603523531 20461750 miR-221 and miR-222 negatively regulate expression of CDKN1B p27 and CDKN1C p57 two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas; Higher miR-222 and miR-221 expression were significantly associated with decreased CDKN1C expression P = 0.009 and 0.01 ovarian cancer hsa-miR-222-3p CDKN1C 1.39382731585819 9.98182478024671e-07 -1.64686390384498 2.97864022905914e-05 miRNAWalker2_validate;miRTarBase;miRNATAP -0.367030260866898 0.000170930172842719 20461750 miR-221 and miR-222 negatively regulate expression of CDKN1B p27 and CDKN1C p57 two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas; Higher miR-222 and miR-221 expression were significantly associated with decreased CDKN1C expression P = 0.009 and 0.01 ovarian cancer hsa-miR-92a-3p CDKN1C 1.2209325870225 6.8757197708107e-06 -1.64686390384498 2.97864022905914e-05 MirTarget;miRNATAP -0.26822515330873 0.00999546781549026 NA NA NA hsa-miR-125b-5p CDKN2A -0.509303501421334 0.133265526313161 1.06173069875751 0.261325871405663 miRNAWalker2_validate -0.581163651183482 0.00347064875298016 23585871 In this study we further extend our studies by showing that miR-125b represses the protein product of the ink4a/ARF locus p14ARF in two prostate cancer cell lines LNCaP wild type-p53 and 22Rv1 both wild type and mutant p53 as well as in the PC-346C prostate cancer xenograft model that lentivirally overexpressed miR-125b; Conversely treatment of prostate cancer cells with an inhibitor of miR-125b anti-miR-125b resulted in increased expression of p14ARF decreased level of Mdm2 and induction of apoptosis; In addition overexpression of miR-125b in p53-deficient PC3 cells induced down-regulation of p14ARF which leads to increased cell proliferation through a p53-independent manner prostate cancer hsa-miR-365a-3p CDKN2A -0.891537000455889 0.0025537650440002 1.06173069875751 0.261325871405663 MirTarget -0.763276937785335 0.000738553773920597 NA NA NA hsa-miR-9-3p CDKN2B 0.330346058941473 0.541111939982661 -0.0272689586225869 0.965486614806745 mirMAP -0.285758816400634 0.000892768940428525 NA NA NA hsa-miR-192-5p CDKN2D 0.0809146624034405 0.941057093528709 0.8632291373548 0.000749307227380925 miRNAWalker2_validate -0.112233273190507 1.60583283546042e-12 NA NA NA hsa-miR-362-3p CDKN2D -0.0349414695893027 0.913780708043777 0.8632291373548 0.000749307227380925 MirTarget;PITA;miRanda;miRNATAP -0.16337600425391 0.0045285477716665 NA NA NA hsa-miR-129-5p CHEK1 -2.56914016541176 2.36237896095709e-06 2.15613840663813 4.74725801073545e-17 miRanda -0.135365909159199 0.000158499471421881 NA NA NA hsa-miR-139-5p CHEK1 -1.83374360776637 1.22019901002824e-09 2.15613840663813 4.74725801073545e-17 miRanda -0.385896206112722 2.21600376918745e-10 NA NA NA hsa-miR-195-5p CHEK1 -0.907998841926297 0.00150511564650591 2.15613840663813 4.74725801073545e-17 MirTarget;miRNATAP -0.337334324952082 6.44181424303598e-07 25840419 MiR 195 suppresses non small cell lung cancer by targeting CHEK1; We discovered that CHEK1 was a direct target of miR-195 which decreased CHEK1 expression in lung cancer cells lung squamous cell cancer hsa-miR-497-5p CHEK1 -0.801030912431774 0.00360386743876612 2.15613840663813 4.74725801073545e-17 MirTarget;miRNATAP -0.345700480248046 1.03574513533624e-06 24464213 Checkpoint kinase 1 is negatively regulated by miR 497 in hepatocellular carcinoma; In silico analysis showed that CHEK1 was a candidate target of miR-497 which was previously found to be downregulated in HCC by us; To test whether miR-497 could bind to 3'untranslated region 3'UTR of CHEK1 luciferase reporter assay was conducted; The result revealed that miR-497 could bind to the 3'untranslated region 3'UTR of CHEK1 mRNA; Western blot showed that ectopic expression of miR-497 suppressed the CHEK1 expression and inhibition of miR-497 led to significant upregulation of CHEK1; Finally miR-497 expression was measured in the same 30 HCC samples and the correlation between miR-497 and CHEK1 was analyzed; The results indicated that miR-497 was downregulated in HCC and had a significant negative correlation with CHEK1; Taken together these results demonstrated that CHEK1 was negatively regulated by miR-497 and the overexpressed CHEK1 was resulted from the downregulated miR-497 in HCC which provided a potential molecular target for HCC therapy liver cancer hsa-miR-186-5p CREBBP 0.149964130725901 0.434709542998771 -0.106993896504943 0.454357945668245 mirMAP;miRNATAP -0.143307553733926 0.0076774519745605 NA NA NA hsa-miR-195-3p DBF4 -1.34779269408059 2.01619826639376e-05 1.6774287901133 3.11279455544986e-11 mirMAP -0.231640050684569 7.71866179595383e-05 NA NA NA hsa-miR-30a-5p DBF4 -1.71922855140016 3.20574349285256e-07 1.6774287901133 3.11279455544986e-11 MirTarget -0.167068143681857 0.00221488012880121 NA NA NA hsa-miR-10a-5p E2F1 -0.470861534765518 0.148803248989189 1.94205321729836 2.08120117702478e-14 miRNAWalker2_validate -0.160967625506339 0.00696564215718466 NA NA NA hsa-miR-125a-5p E2F2 -0.878090699011564 0.000213630844319685 2.78773808416368 8.04592297459092e-16 MirTarget -0.400886429258296 0.000322860483583033 NA NA NA hsa-miR-125b-5p E2F2 -0.509303501421334 0.133265526313161 2.78773808416368 8.04592297459092e-16 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.216413794794156 0.00602647756160276 22999819 miR 125b regulates the proliferation of glioblastoma stem cells by targeting E2F2; This study demonstrated that miR-125b plays important roles in regulating the proliferation of GSCs by directly targeting E2F2 glioblastoma hsa-miR-101-3p E2F3 -0.451263906815861 0.0283387250173031 1.25881043745277 7.74479898410618e-11 miRNAWalker2_validate -0.238499836032183 0.000776354814460717 NA NA NA hsa-miR-10a-5p E2F3 -0.470861534765518 0.148803248989189 1.25881043745277 7.74479898410618e-11 miRNATAP -0.120546693417046 0.00662720935313833 NA NA NA hsa-miR-145-5p E2F3 -1.75133578902314 1.54965572197748e-05 1.25881043745277 7.74479898410618e-11 miRNATAP -0.143418662597802 3.05969778762418e-05 25762621 miR 145 mediates the antiproliferative and gene regulatory effects of vitamin D3 by directly targeting E2F3 in gastric cancer cells; Furthermore miR-145 expression was lower in tumors compared with matched normal samples and correlated with increased the E2F3 transcription factor protein staining gastric cancer hsa-miR-195-5p E2F3 -0.907998841926297 0.00150511564650591 1.25881043745277 7.74479898410618e-11 miRNAWalker2_validate;miRTarBase;miRNATAP -0.227190025341893 4.20404866921555e-06 22217655 We identified E2F3 and CCND3 as functional downstream targets of miR-195 in glioblastoma cells glioblastoma hsa-miR-497-5p E2F3 -0.801030912431774 0.00360386743876612 1.25881043745277 7.74479898410618e-11 miRNATAP -0.177675787004688 0.000654872484103964 NA NA NA hsa-let-7a-2-3p E2F5 0.195895719455896 0.643556335039042 0.528082183816752 0.222861387044548 MirTarget -0.23969221806315 0.00118295361432504 NA NA NA hsa-let-7b-5p E2F5 0.0582902155815681 0.781400138984745 0.528082183816752 0.222861387044548 miRNAWalker2_validate;MirTarget;miRNATAP -0.70765537032331 1.53123383550011e-06 NA NA NA hsa-let-7c-5p E2F5 -0.503482361446512 0.206848395212976 0.528082183816752 0.222861387044548 MirTarget -0.215001796569756 0.00545065963297017 NA NA NA hsa-miR-1-3p E2F5 -2.66410453456934 1.50620580537836e-05 0.528082183816752 0.222861387044548 MirTarget -0.133925452412644 0.00625804411975673 NA NA NA hsa-miR-1271-5p E2F5 1.15538250415776 0.00207865862606828 0.528082183816752 0.222861387044548 MirTarget -0.272336937985371 0.000928513572609361 NA NA NA hsa-miR-199a-5p E2F5 0.371973504507027 0.232661597228763 0.528082183816752 0.222861387044548 miRanda -0.369514332829906 0.000181379362501828 NA NA NA hsa-miR-199b-5p E2F5 0.124595928096068 0.678156859366405 0.528082183816752 0.222861387044548 miRanda -0.284795407066096 0.00596745058157698 NA NA NA hsa-miR-205-5p E2F5 3.13520672931882 0.0293226471971167 0.528082183816752 0.222861387044548 miRNAWalker2_validate;miRTarBase;miRNATAP -0.159485705963308 7.86645578257464e-16 21454583 The expression levels of E2F1 and E2F5 were correlated inversely with that of miR-205 in melanoma cell lines; miR-205 significantly suppressed the luciferase activity of reporter plasmids containing the 3'-UTR sequences complementary to either E2F1 or E2F5; Overexpression of miR-205 in melanoma cells reduced E2F1 and E2F5 protein levels melanoma hsa-miR-337-3p E2F5 -0.722905798364932 0.0337389336330079 0.528082183816752 0.222861387044548 MirTarget;PITA -0.312790022373909 0.000512629588841258 NA NA NA hsa-miR-34c-5p E2F5 2.20632574870337 0.000379662996168678 0.528082183816752 0.222861387044548 MirTarget;PITA;miRanda;miRNATAP -0.276929982376722 5.85161101463985e-09 NA NA NA hsa-miR-106b-5p EP300 1.70863907461894 2.04074794107142e-08 0.0301764271351921 0.833038220279424 miRNATAP -0.100179986132884 0.00163708231399858 NA NA NA hsa-miR-212-3p EP300 0.960352937108106 0.00133449812322732 0.0301764271351921 0.833038220279424 MirTarget;miRNATAP -0.119462144893836 0.000325617297555144 NA NA NA hsa-miR-26a-5p EP300 -0.384110714440647 0.0442498636014044 0.0301764271351921 0.833038220279424 miRNATAP -0.189916321506519 0.000381014097443189 NA NA NA hsa-miR-26b-5p EP300 -0.301646326928219 0.160081421968103 0.0301764271351921 0.833038220279424 miRNAWalker2_validate;miRNATAP -0.141211197444202 0.00298659835807985 NA NA NA hsa-miR-10a-5p ESPL1 -0.470861534765518 0.148803248989189 3.23567528478474 4.04819485548261e-18 miRNAWalker2_validate -0.270749401404039 0.00244463886284126 NA NA NA hsa-miR-125a-5p ESPL1 -0.878090699011564 0.000213630844319685 3.23567528478474 4.04819485548261e-18 miRanda -0.433570882278893 0.000366573463478448 NA NA NA hsa-miR-10a-5p FZR1 -0.470861534765518 0.148803248989189 0.429818226214662 0.0101468531877406 mirMAP -0.117005366639032 0.00131274488654146 NA NA NA hsa-miR-125a-5p FZR1 -0.878090699011564 0.000213630844319685 0.429818226214662 0.0101468531877406 mirMAP -0.160010431702034 0.00131799220800409 NA NA NA hsa-miR-148a-3p FZR1 -1.53721533763578 3.55533747293117e-05 0.429818226214662 0.0101468531877406 mirMAP -0.126878090165583 4.25695882765362e-05 NA NA NA hsa-miR-326 FZR1 -0.429748586406214 0.2629894124021 0.429818226214662 0.0101468531877406 mirMAP -0.139549911958291 5.89829129369527e-06 NA NA NA hsa-miR-335-5p FZR1 1.59953351087307 5.56170899867314e-05 0.429818226214662 0.0101468531877406 mirMAP -0.103684832628611 0.000383678501160975 NA NA NA hsa-miR-339-5p FZR1 0.770566566962108 0.00816529093411862 0.429818226214662 0.0101468531877406 mirMAP -0.125590939651024 0.00201202192024154 NA NA NA hsa-miR-361-3p FZR1 -0.126462931388735 0.566052688733137 0.429818226214662 0.0101468531877406 mirMAP -0.218955488950822 5.59073311440851e-05 NA NA NA hsa-miR-423-5p FZR1 0.832613878736338 0.000791321227103338 0.429818226214662 0.0101468531877406 mirMAP -0.224578094327714 1.7002492087331e-06 NA NA NA hsa-miR-532-3p FZR1 0.552364451472481 0.0975490365586023 0.429818226214662 0.0101468531877406 mirMAP -0.117420347406778 0.000956093704204557 NA NA NA hsa-miR-148b-3p GADD45A 0.295175884456199 0.17466422420702 -0.744381186012481 0.00247182040910746 MirTarget -0.214957101032821 0.00927854827400905 NA NA NA hsa-miR-454-3p GADD45A 0.625199142970745 0.0134890997402741 -0.744381186012481 0.00247182040910746 MirTarget;miRNATAP -0.217978566953222 0.00180852644098547 NA NA NA hsa-miR-1976 GADD45B 0.923172654386147 0.000118514313506673 -1.91754262778042 5.17429057228523e-08 miRNATAP -0.58594227558951 2.17579979542256e-08 NA NA NA hsa-miR-324-3p GADD45B 1.04940352369965 0.000387716796520961 -1.91754262778042 5.17429057228523e-08 MirTarget;miRNATAP -0.3687003729794 1.78715342431653e-05 NA NA NA hsa-miR-590-3p GADD45B 1.11654983899947 0.000160782154924864 -1.91754262778042 5.17429057228523e-08 miRanda -0.368023929046783 1.76170990966765e-05 NA NA NA hsa-miR-296-5p GADD45G 0.932146077883618 0.0602370559607489 -1.30721241002926 0.000929668878156123 miRNATAP -0.168728470747373 0.00456954912760057 NA NA NA hsa-miR-101-3p GSK3B -0.451263906815861 0.0283387250173031 0.173686703054757 0.358761637442374 miRNATAP -0.309746385838821 1.76772309214892e-06 NA NA NA hsa-miR-212-3p GSK3B 0.960352937108106 0.00133449812322732 0.173686703054757 0.358761637442374 mirMAP;miRNATAP -0.157580688036431 0.000373666664591505 NA NA NA hsa-miR-26a-5p GSK3B -0.384110714440647 0.0442498636014044 0.173686703054757 0.358761637442374 miRNAWalker2_validate;miRNATAP -0.297404702806196 2.62046086511681e-05 NA NA NA hsa-miR-26b-5p GSK3B -0.301646326928219 0.160081421968103 0.173686703054757 0.358761637442374 miRNATAP -0.202543608293146 0.00135911800763895 NA NA NA hsa-miR-29a-3p GSK3B -0.113012156986374 0.615005009685815 0.173686703054757 0.358761637442374 miRNATAP -0.237953626141529 7.3117565138463e-05 NA NA NA hsa-miR-29b-3p GSK3B -0.230693226193598 0.367461626035234 0.173686703054757 0.358761637442374 miRTarBase;miRNATAP -0.139976205675035 0.00818133109022919 NA NA NA hsa-miR-29c-3p GSK3B -1.62454036584589 5.38376515586029e-07 0.173686703054757 0.358761637442374 miRNATAP -0.149008148419369 0.000186841384822779 NA NA NA hsa-miR-30d-3p GSK3B -0.545113326540761 0.0433733076874155 0.173686703054757 0.358761637442374 miRNATAP -0.134805668946892 0.00688448679166308 NA NA NA hsa-miR-340-5p GSK3B -0.164941927483643 0.529910509321278 0.173686703054757 0.358761637442374 mirMAP -0.184933292640156 0.000302021889990012 NA NA NA hsa-miR-342-3p HDAC1 0.318119432680668 0.269150960124243 0.784065504987803 4.05383814767719e-06 miRanda -0.134814787267207 0.00172083743938278 NA NA NA hsa-miR-145-5p HDAC2 -1.75133578902314 1.54965572197748e-05 0.542710762381445 0.000828127815013922 miRNAWalker2_validate -0.124030510119461 6.69047341696702e-06 23499894 MiR 145 functions as a tumor suppressor by directly targeting histone deacetylase 2 in liver cancer; Ectopic expression of miRNA mimics evidenced that miR-145 suppresses HDAC2 expression in HCC cells; In conclusion we suggest that loss or suppression of miR-145 may cause aberrant overexpression of HDAC2 and promote HCC tumorigenesis tumorigenesis liver cancer hsa-miR-195-3p HDAC2 -1.34779269408059 2.01619826639376e-05 0.542710762381445 0.000828127815013922 mirMAP -0.140645211882781 8.93603828833916e-05 NA NA NA hsa-miR-30a-3p HDAC2 -1.73205137750899 3.2425754511091e-07 0.542710762381445 0.000828127815013922 mirMAP -0.105686746205829 0.00142603990586771 NA NA NA hsa-miR-30a-5p HDAC2 -1.71922855140016 3.20574349285256e-07 0.542710762381445 0.000828127815013922 mirMAP -0.113207139255158 0.000686202544426317 NA NA NA hsa-miR-139-5p MAD2L1 -1.83374360776637 1.22019901002824e-09 2.85507519354302 7.72980461131798e-25 miRanda -0.399292364336441 7.75070749745255e-09 NA NA NA hsa-miR-139-5p MCM2 -1.83374360776637 1.22019901002824e-09 2.70709664838378 1.38778192091381e-16 miRanda -0.418711118241385 1.00213608980406e-07 NA NA NA hsa-miR-500a-5p MCM2 0.00337014556047865 0.992120109131868 2.70709664838378 1.38778192091381e-16 miRNAWalker2_validate -0.196301532002236 0.00857486185487728 NA NA NA hsa-miR-129-5p MCM4 -2.56914016541176 2.36237896095709e-06 2.25333736563101 6.83776452424251e-16 miRanda -0.119016262120038 0.00224809866112284 NA NA NA hsa-miR-338-3p MCM4 -0.959276231066179 0.0191473351014091 2.25333736563101 6.83776452424251e-16 MirTarget;miRanda -0.204081824865884 7.831487823234e-05 NA NA NA hsa-miR-143-3p MDM2 -0.661937718854688 0.0483213962135842 0.0953337413007871 0.725153770779448 miRNAWalker2_validate -0.192980048252097 0.000726275884433861 NA NA NA hsa-let-7g-5p MYC 0.325297685027927 0.241142963826631 0.519157788027723 0.0906694636452631 miRNAWalker2_validate;miRTarBase -0.208004338135784 0.00889968380877331 NA NA NA hsa-miR-26a-5p MYC -0.384110714440647 0.0442498636014044 0.519157788027723 0.0906694636452631 miRNAWalker2_validate -0.595250601703361 1.86863162610225e-07 21901171 Our results identify new molecular targets of c-Myc in AML and highlight miR-26a attractiveness as a therapeutic target in leukemia acute myeloid leukemia hsa-miR-335-5p MYC 1.59953351087307 5.56170899867314e-05 0.519157788027723 0.0906694636452631 miRNAWalker2_validate -0.211331388667708 7.8766835557931e-05 NA NA NA hsa-miR-34a-5p MYC 0.794251341270032 0.00024017386701179 0.519157788027723 0.0906694636452631 miRNAWalker2_validate;miRTarBase -0.342899797750895 0.000672118391671011 25572695;25686834;21460242;22159222;23640973;22830357;22235332 The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;miR 34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c Myc pathway;Myc mediated repression of microRNA 34a promotes high grade transformation of B cell lymphoma by dysregulation of FoxP1;MicroRNA 34a suppresses malignant transformation by targeting c Myc transcriptional complexes in human renal cell carcinoma; We investigated the functional effects of microRNA-34a miR-34a on c-Myc transcriptional complexes in renal cell carcinoma; miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region which was revealed by luciferase reporter assays; Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription indicating a novel role of miR-34a in the regulation of transcription by c-Myc;Among them miR-34a was also associated with poor prognosis in 2 independent series of leukemic and nodal MCL and in cooperation with high expression of the MYC oncogene;We report that miR-34a did not inhibit cell proliferation notwithstanding a marked down-regulation of c-MYC;MicroRNA 34a modulates c Myc transcriptional complexes to suppress malignancy in human prostate cancer cells; We studied the functional effects of miR-34a on c-Myc transcriptional complexes in PC-3 prostate cancer cells; miR-34a downregulated expression of c-Myc oncogene by targeting its 3' UTR as shown by luciferase reporter assays; This is the first report to document that miR-34a suppresses assembly and function of the c-Myc-Skp2-Miz1 complex that activates RhoA and the c-Myc-pTEFB complex that elongates transcription of various genes suggesting a novel role of miR-34a in the regulation of transcription by c-Myc complex ;;;malignant trasformation;worse prognosis;; bladder cancer;liver cancer;B cell lymphoma;kidney renal cell cancer;lymphoma;lymphoma;prostate cancer hsa-miR-423-5p MYC 0.832613878736338 0.000791321227103338 0.519157788027723 0.0906694636452631 miRNAWalker2_validate -0.242528994449528 0.00588609161419062 NA NA NA hsa-miR-30a-5p PCNA -1.71922855140016 3.20574349285256e-07 1.8887075142003 7.95673685110244e-15 miRNAWalker2_validate -0.256182189645259 1.13149570248782e-06 NA NA NA hsa-miR-338-5p PCNA -1.19659203838734 0.0100316010080496 1.8887075142003 7.95673685110244e-15 PITA -0.113642911135151 0.00414578701503734 NA NA NA hsa-miR-100-5p PLK1 -0.909635282943505 0.0262703445792608 3.35956784701485 2.17940054442559e-25 miRNAWalker2_validate;miRTarBase -0.228247202164584 0.000306464253359417 23151088;22246341;23842624;25537513;22120675;21636267 MicroRNA 100 is a potential molecular marker of non small cell lung cancer and functions as a tumor suppressor by targeting polo like kinase 1; By using microRNA miR target prediction algorithms we identified miR-100 that might potentially bind the 3'-untranslated region of PLK1 transcripts; The purpose of this study was to investigate the roles of miR-100 and its association with PLK1 in NSCLC development; Finally the effects of miR-100 expression on growth apoptosis and cell cycle of NSCLC cells by posttranscriptionally regulating PLK1 expression were determined; Meanwhile miR-100 mimics could significantly inhibit PLK1 mRNA and protein expression and reduce the luciferase activity of a PLK1 3' untranslated region-based reporter construct in A549 cells; Furthermore small interfering RNA siRNA-mediated PLK1 downregulation could mimic the effects of miR-100 mimics while PLK1 overexpression could partially rescue the phenotypical changes of NSCLC cells induced by miR-100 mimics; Our findings indicate that low miR-100 may be a poor prognostic factor for NSCLC patients and functions as a tumor suppressor by posttranscriptionally regulating PLK1 expression;Together these results suggest that low miR-100 expression may be an independent poor prognostic factor and miR-100 can function as a tumor suppressor by targeting PLK1 in human EOCs;In HCC tissues miR-100 expression was inversely correlated with the expression of plk1 protein r = -0.418; P = 0.029; Therefore downregulation of miR-100 was correlated with progressive pathological feature and poor prognosis in HCC patients and miR-100 could function as a tumor suppressor by targeting plk1;Here we show that miR-100 inhibits maintenance and expansion of BrCSCs in basal-like cancer through Polo-like kinase1 Plk1 down-regulation;MiR 100 resensitizes docetaxel resistant human lung adenocarcinoma cells SPC A1 to docetaxel by targeting Plk1; Knock-down of Plk1 which was a direct target of miR-100 yielded similar effects as that of ectopic miR-100 expression; The inverse correlation between miR-100 and Plk1 expression was also detected in nude mice SPC-A1/DTX tumor xenografts and clinical lung adenocarcinoma tissues and was proved to be related with the in vivo response to docetaxel; Thus our results suggested that down-regulation of miR-100 could lead to Plk1 over-expression and eventually to docetaxel chemoresistance of human lung adenocarcinoma;Reduced miR 100 expression in cervical cancer and precursors and its carcinogenic effect through targeting PLK1 protein; Through modulating miR-100 expression using miR-100 inhibitor or mimic in vitro cell growth cycle and apoptosis were tested separately by MTT or flow cytometry and meanwhile Polo-like kinase1 PLK1 mRNA and protein expressions were detected by qRT-PCR and immunoblotting; The expression of PLK1 in 125 cervical tissues was also examined by immunohistochemical staining and the correlation between miR-100 and PLK1 expression in the same tissues was analysed; The modulation of miR-100 expression remarkably influenced cell proliferation cycle and apoptosis as well as the level of PLK1 protein but not mRNA in vitro experiments; PLK1 expression was negatively correlated with miR-100 expression in CIN3 and cervical cancer tissues; The reduced miR-100 expression participates in the development of cervical cancer at least partly through loss of inhibition to target gene PLK1 which probably occurs in a relative late phase of carcinogenesis ;;progression;worse prognosis;;drug resistance;tumorigenesis lung squamous cell cancer;ovarian cancer;liver cancer;breast cancer;lung cancer;cervical and endocervical cancer hsa-miR-101-5p PRKDC -0.567139223563276 0.0306291767849722 1.05129575425253 1.62867714728687e-06 miRNAWalker2_validate;miRTarBase -0.205170047679699 0.000795566589675988 22014955 Although ectopic miR-101 efficiently decreased the ATM and DNA-PKcs levels and increased the radiosensitization level in H1299 H1975 and A549 cells it did not change the levels of the miR-101 targets or radiosensitivity in H157 cells lung squamous cell cancer hsa-miR-126-5p RAD21 0.41765430251855 0.0753161203651532 0.719027248712392 4.40905219716591e-05 mirMAP -0.157573062566854 0.00392441592307901 NA NA NA hsa-miR-139-5p RAD21 -1.83374360776637 1.22019901002824e-09 0.719027248712392 4.40905219716591e-05 miRanda -0.180872120235151 5.33408027769384e-06 NA NA NA hsa-miR-140-5p RAD21 0.208193069681326 0.303002433893804 0.719027248712392 4.40905219716591e-05 miRanda -0.267147467656544 2.49378400341627e-05 NA NA NA hsa-miR-181c-5p RAD21 0.336826967681288 0.112932307913601 0.719027248712392 4.40905219716591e-05 MirTarget;miRNATAP -0.158036873000234 0.00940058106804693 NA NA NA hsa-miR-195-3p RAD21 -1.34779269408059 2.01619826639376e-05 0.719027248712392 4.40905219716591e-05 MirTarget;miRNATAP -0.116631625721547 0.003234256953241 NA NA NA hsa-miR-30a-3p RAD21 -1.73205137750899 3.2425754511091e-07 0.719027248712392 4.40905219716591e-05 MirTarget -0.192085190379175 5.59405857082982e-08 NA NA NA hsa-miR-30e-3p RAD21 -0.913131357083321 7.29096855615228e-06 0.719027248712392 4.40905219716591e-05 MirTarget -0.220143654865869 0.000361044744156042 NA NA NA hsa-miR-338-5p RAD21 -1.19659203838734 0.0100316010080496 0.719027248712392 4.40905219716591e-05 MirTarget;PITA;miRNATAP -0.106437797398182 7.07700671520702e-05 NA NA NA hsa-miR-362-3p RAD21 -0.0349414695893027 0.913780708043777 0.719027248712392 4.40905219716591e-05 miRanda -0.112444880442146 0.0045509926999407 NA NA NA hsa-let-7e-5p RB1 0.405855894534493 0.196257828016759 0.457943171078819 0.0450553652619436 miRNATAP -0.137849991348367 0.00809727382557999 NA NA NA hsa-miR-125a-5p RB1 -0.878090699011564 0.000213630844319685 0.457943171078819 0.0450553652619436 miRanda -0.184509353154955 0.00703712477024134 NA NA NA hsa-miR-129-5p RB1 -2.56914016541176 2.36237896095709e-06 0.457943171078819 0.0450553652619436 MirTarget;miRanda -0.101148219905939 0.000576089161770026 NA NA NA hsa-miR-143-3p RB1 -0.661937718854688 0.0483213962135842 0.457943171078819 0.0450553652619436 miRNATAP -0.134391927538503 0.0056050362772892 NA NA NA hsa-miR-212-3p RB1 0.960352937108106 0.00133449812322732 0.457943171078819 0.0450553652619436 miRNAWalker2_validate;miRTarBase;MirTarget -0.165015718784211 0.0022730768935431 NA NA NA hsa-miR-26a-5p RB1 -0.384110714440647 0.0442498636014044 0.457943171078819 0.0450553652619436 miRNAWalker2_validate;miRTarBase;MirTarget -0.279420940926579 0.00128569999558002 NA NA NA hsa-miR-30e-3p RB1 -0.913131357083321 7.29096855615228e-06 0.457943171078819 0.0450553652619436 MirTarget -0.317262103929389 5.62848382329836e-05 NA NA NA hsa-miR-129-5p RBL1 -2.56914016541176 2.36237896095709e-06 1.73175096071293 5.88412178647195e-13 miRanda -0.123825558622677 0.000157089321291439 NA NA NA hsa-miR-106b-5p RBL2 1.70863907461894 2.04074794107142e-08 -0.554881951006322 0.000774596666255453 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.181136412099074 7.86544607170665e-07 NA NA NA hsa-miR-107 RBL2 0.904627575346218 4.67936495073904e-05 -0.554881951006322 0.000774596666255453 miRanda -0.257137578949083 6.89556080677443e-07 NA NA NA hsa-miR-126-5p RBL2 0.41765430251855 0.0753161203651532 -0.554881951006322 0.000774596666255453 MirTarget -0.162975507515902 0.00129998272063549 NA NA NA hsa-miR-142-5p RBL2 1.55592486377018 6.69269968016779e-06 -0.554881951006322 0.000774596666255453 PITA -0.136782399094381 3.42700164897742e-05 NA NA NA hsa-miR-17-5p RBL2 1.65862087862483 8.45603406215941e-08 -0.554881951006322 0.000774596666255453 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.126609858780632 0.000578098831951693 NA NA NA hsa-miR-335-3p RBL2 2.5197689063267 2.20084506976733e-09 -0.554881951006322 0.000774596666255453 MirTarget -0.109624102840946 3.47422532505056e-05 NA NA NA hsa-miR-335-5p RBL2 1.59953351087307 5.56170899867314e-05 -0.554881951006322 0.000774596666255453 miRNAWalker2_validate -0.126076376916647 1.15786986275277e-05 NA NA NA hsa-miR-421 RBL2 1.80720854070385 1.59709651202848e-07 -0.554881951006322 0.000774596666255453 miRanda -0.173135223671567 8.34206369604049e-08 NA NA NA hsa-miR-590-3p RBL2 1.11654983899947 0.000160782154924864 -0.554881951006322 0.000774596666255453 miRanda -0.125315066580303 0.0014460219589258 NA NA NA hsa-miR-93-5p RBL2 1.7515174434778 1.59386482413883e-08 -0.554881951006322 0.000774596666255453 MirTarget;miRNATAP -0.104755353156969 0.00439035106128891 NA NA NA hsa-miR-338-5p RBX1 -1.19659203838734 0.0100316010080496 0.286807542627776 0.106420949103239 PITA;miRNATAP -0.106531470265194 5.95761073058241e-05 NA NA NA hsa-miR-142-3p SKP1 1.32364054836498 0.0001537753622128 -0.199087092640564 0.151939628767957 miRanda -0.110360009944335 5.0591705671076e-05 NA NA NA hsa-miR-7-1-3p SKP1 0.709309110750947 0.0412301737463194 -0.199087092640564 0.151939628767957 MirTarget;mirMAP -0.123371433259091 8.07856727287148e-06 NA NA NA hsa-miR-30a-5p SKP2 -1.71922855140016 3.20574349285256e-07 1.64609982207667 1.63370907786227e-08 MirTarget;miRNATAP -0.238757556392343 0.000108350997632302 NA NA NA hsa-miR-378c SKP2 -1.27752074861415 2.73676010235611e-05 1.64609982207667 1.63370907786227e-08 MirTarget;miRNATAP -0.198599972491595 0.00433655972147301 NA NA NA hsa-miR-142-5p SMAD2 1.55592486377018 6.69269968016779e-06 -0.300765856171448 0.10851640185339 mirMAP;miRNATAP -0.121258906437032 0.00121258964778295 NA NA NA hsa-miR-148b-3p SMAD2 0.295175884456199 0.17466422420702 -0.300765856171448 0.10851640185339 MirTarget;mirMAP -0.188431302458534 0.00237431170323455 NA NA NA hsa-miR-338-5p SMAD2 -1.19659203838734 0.0100316010080496 -0.300765856171448 0.10851640185339 mirMAP -0.1164613959073 3.14493757487898e-05 NA NA NA hsa-miR-361-3p SMAD2 -0.126462931388735 0.566052688733137 -0.300765856171448 0.10851640185339 miRNATAP -0.221052512732111 0.000287801161304295 22675530 Functional analyses showed that Smad2 and TGFß1 are not dysregulated by miR-361-3p and miR-625* in the lung cell line A549 respectively lung cancer hsa-miR-3614-5p SMAD2 1.10426689932954 0.00706308396674599 -0.300765856171448 0.10851640185339 mirMAP -0.138520175891015 1.61724289790087e-05 NA NA NA hsa-miR-362-3p SMAD2 -0.0349414695893027 0.913780708043777 -0.300765856171448 0.10851640185339 PITA;miRNATAP -0.122162976410172 0.00320094476209477 NA NA NA hsa-miR-501-5p SMAD2 0.266919328110625 0.454779001968586 -0.300765856171448 0.10851640185339 mirMAP -0.104465988541894 0.00508261334911037 NA NA NA hsa-miR-532-5p SMAD2 0.313080805824184 0.252248939356301 -0.300765856171448 0.10851640185339 MirTarget -0.141928514558377 0.00372479166804462 NA NA NA hsa-miR-652-3p SMAD2 1.02742852909286 0.000337974815149397 -0.300765856171448 0.10851640185339 miRNAWalker2_validate -0.133269515054385 0.00370559099257 NA NA NA hsa-miR-7-1-3p SMAD2 0.709309110750947 0.0412301737463194 -0.300765856171448 0.10851640185339 mirMAP -0.128099023068285 0.000745445261862172 NA NA NA hsa-miR-29b-2-5p SMAD3 -1.7015307882027 2.84239251703401e-10 0.496358301383941 0.0477537564173643 mirMAP -0.245782961497944 9.53741523036621e-05 NA NA NA hsa-miR-326 SMAD3 -0.429748586406214 0.2629894124021 0.496358301383941 0.0477537564173643 miRanda -0.188699053546072 5.05451980443311e-05 NA NA NA hsa-miR-501-5p SMAD3 0.266919328110625 0.454779001968586 0.496358301383941 0.0477537564173643 mirMAP -0.172629265416163 0.000540972457841411 NA NA NA hsa-let-7f-1-3p SMAD4 1.28704406797397 1.17954701106157e-06 -0.824257248233094 0.000189487671904837 mirMAP -0.220578983472878 0.000160738336591292 NA NA NA hsa-miR-106b-5p SMAD4 1.70863907461894 2.04074794107142e-08 -0.824257248233094 0.000189487671904837 mirMAP;miRNATAP -0.162181577178144 0.00128196766251867 NA NA NA hsa-miR-10b-3p SMAD4 0.773619331000039 0.0076628900286607 -0.824257248233094 0.000189487671904837 miRNATAP -0.242227670204784 7.12567725926528e-06 NA NA NA hsa-miR-142-5p SMAD4 1.55592486377018 6.69269968016779e-06 -0.824257248233094 0.000189487671904837 mirMAP -0.170942442548877 0.00013009423445379 NA NA NA hsa-miR-188-5p SMAD4 1.35426907033843 0.00038346077691455 -0.824257248233094 0.000189487671904837 mirMAP -0.13185965458528 0.00131015049885176 NA NA NA hsa-miR-330-3p SMAD4 0.798460296022179 0.00746538156533435 -0.824257248233094 0.000189487671904837 mirMAP -0.142069953334962 0.0076701388483449 NA NA NA hsa-miR-3614-5p SMAD4 1.10426689932954 0.00706308396674599 -0.824257248233094 0.000189487671904837 mirMAP -0.1516680963036 8.74983580862871e-05 NA NA NA hsa-miR-3922-3p SMAD4 1.33252322927569 0.000665307190249975 -0.824257248233094 0.000189487671904837 miRNATAP -0.123847527593907 0.00790979730625974 NA NA NA hsa-miR-421 SMAD4 1.80720854070385 1.59709651202848e-07 -0.824257248233094 0.000189487671904837 miRTarBase;miRanda;miRNATAP -0.118947234882816 0.00792590774144633 NA NA NA hsa-miR-550a-3p SMAD4 2.05849884025997 7.99642185793604e-07 -0.824257248233094 0.000189487671904837 mirMAP -0.10817430665783 0.00838028029306833 NA NA NA hsa-miR-101-3p SMC1A -0.451263906815861 0.0283387250173031 0.336441708563362 0.0386809236046258 mirMAP -0.174975094804845 0.00205897947609504 NA NA NA hsa-miR-26b-5p STAG1 -0.301646326928219 0.160081421968103 0.172712254979712 0.337439560119409 miRNAWalker2_validate -0.211416436686927 0.000420114523208992 NA NA NA hsa-miR-30b-5p STAG1 -0.430720743745757 0.0593564057320791 0.172712254979712 0.337439560119409 MirTarget -0.162031239017474 0.00403734693873657 NA NA NA hsa-miR-101-3p STAG2 -0.451263906815861 0.0283387250173031 0.425098124571101 0.00627293894652006 MirTarget;miRNATAP -0.164222210189003 0.00257013270039207 NA NA NA hsa-miR-30a-3p TFDP1 -1.73205137750899 3.2425754511091e-07 1.00011225694424 3.72691039625758e-06 MirTarget;miRNATAP -0.215006978125061 1.12457593162032e-06 NA NA NA hsa-miR-30a-5p TFDP1 -1.71922855140016 3.20574349285256e-07 1.00011225694424 3.72691039625758e-06 MirTarget;miRNATAP -0.258750464572731 3.76390905562785e-09 NA NA NA hsa-miR-30c-5p TFDP1 -0.983130268805942 4.60419218706127e-05 1.00011225694424 3.72691039625758e-06 MirTarget;miRNATAP -0.249117300236063 0.000102573145827171 NA NA NA hsa-miR-338-3p TFDP1 -0.959276231066179 0.0191473351014091 1.00011225694424 3.72691039625758e-06 PITA;miRanda -0.106875632184371 0.00512930499757797 NA NA NA hsa-miR-212-3p TFDP2 0.960352937108106 0.00133449812322732 0.263152325949781 0.259630061766931 mirMAP -0.167439962662877 0.00235726097939536 NA NA NA hsa-miR-29a-3p TFDP2 -0.113012156986374 0.615005009685815 0.263152325949781 0.259630061766931 mirMAP -0.214865755620647 0.00416435033470775 NA NA NA hsa-miR-139-5p TGFB1 -1.83374360776637 1.22019901002824e-09 0.921978024389205 0.015443067273438 miRanda -0.231228229661 0.00779949032347728 NA NA NA hsa-miR-29b-3p TGFB1 -0.230693226193598 0.367461626035234 0.921978024389205 0.015443067273438 miRTarBase -0.456958304413375 1.70622144738106e-05 NA NA NA hsa-miR-141-3p TGFB2 1.45548825076434 0.00115958850961764 0.531711555933475 0.237271821958403 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.310711996035385 7.80220336778334e-06 NA NA NA hsa-miR-148a-3p TGFB2 -1.53721533763578 3.55533747293117e-05 0.531711555933475 0.237271821958403 MirTarget;miRNATAP -0.220405364068209 0.00926503682050518 NA NA NA hsa-miR-148b-3p TGFB2 0.295175884456199 0.17466422420702 0.531711555933475 0.237271821958403 MirTarget -0.467759048012148 0.00176540723814519 NA NA NA hsa-miR-200a-3p TGFB2 0.717826667295984 0.193912116506827 0.531711555933475 0.237271821958403 MirTarget;miRNATAP -0.252010151933484 9.49127408816544e-06 25813153 Tumor suppressive microRNA 200a inhibits renal cell carcinoma development by directly targeting TGFB2; By performing quantitative real-time PCR ELISA and luciferase reporter assays transforming growth factor beta2 TGFB2 was validated as a direct target gene of miR-200a; Moreover siRNA-mediated knockdown of TGFB2 partially phenocopied the effect of miR-200a overexpression; These results suggest that miR-200a suppresses RCC development via directly targeting TGFB2 indicating that miR-200a may present a novel target for diagnostic and therapeutic strategies in RCC kidney renal cell cancer hsa-miR-203a-3p TGFB2 1.44736908507496 0.0394116388736904 0.531711555933475 0.237271821958403 MirTarget -0.165925482602356 0.000218164630138837 NA NA NA hsa-miR-32-3p TGFB2 0.583525764322974 0.11837203008551 0.531711555933475 0.237271821958403 mirMAP -0.25717146688254 0.00779413036125543 NA NA NA hsa-miR-330-3p TGFB2 0.798460296022179 0.00746538156533435 0.531711555933475 0.237271821958403 miRNATAP -0.296195247581737 0.00574751539933769 NA NA NA hsa-miR-33a-3p TGFB2 0.347011402017138 0.321709379745392 0.531711555933475 0.237271821958403 MirTarget;mirMAP -0.39918681868845 2.86864367014074e-05 NA NA NA hsa-miR-375 TGFB2 -2.94506033785642 0.00570147601654791 0.531711555933475 0.237271821958403 miRNAWalker2_validate -0.135378292973885 3.38653961690956e-06 NA NA NA hsa-miR-429 TGFB2 1.40182602301928 0.00900426780286475 0.531711555933475 0.237271821958403 miRNATAP -0.282945695650806 1.02668418456713e-06 NA NA NA hsa-let-7f-1-3p TGFB3 1.28704406797397 1.17954701106157e-06 -1.10894161909252 0.00498726268551547 MirTarget -0.272732273807511 0.00950753209568666 NA NA NA hsa-miR-10a-5p TGFB3 -0.470861534765518 0.148803248989189 -1.10894161909252 0.00498726268551547 miRNAWalker2_validate -0.277127145258827 0.00143360908543031 NA NA NA hsa-miR-151a-5p TGFB3 1.24363461949586 2.18236940049108e-07 -1.10894161909252 0.00498726268551547 MirTarget -0.661467214905873 3.42539039149492e-09 NA NA NA hsa-miR-26b-3p TGFB3 -0.0103961389461977 0.965770899625511 -1.10894161909252 0.00498726268551547 MirTarget -0.511617229426091 1.24500682090535e-05 NA NA NA hsa-miR-29a-3p TGFB3 -0.113012156986374 0.615005009685815 -1.10894161909252 0.00498726268551547 miRNAWalker2_validate -0.395874477357522 0.00201300163223496 NA NA NA hsa-miR-29b-3p TGFB3 -0.230693226193598 0.367461626035234 -1.10894161909252 0.00498726268551547 miRTarBase -0.379512133029508 0.000666754329763779 NA NA NA hsa-miR-338-5p TGFB3 -1.19659203838734 0.0100316010080496 -1.10894161909252 0.00498726268551547 PITA -0.236666190238514 7.75982569882353e-05 NA NA NA hsa-miR-590-3p TGFB3 1.11654983899947 0.000160782154924864 -1.10894161909252 0.00498726268551547 miRanda -0.312543185476898 0.000937918421040375 NA NA NA hsa-miR-629-3p TGFB3 1.40326397107309 9.7803063526732e-05 -1.10894161909252 0.00498726268551547 MirTarget -0.252264250229092 0.00108443910675355 NA NA NA hsa-miR-129-5p TTK -2.56914016541176 2.36237896095709e-06 2.84986704208266 9.02670730756391e-19 miRanda -0.15940694822748 0.000465289155644025 NA NA NA hsa-miR-139-5p TTK -1.83374360776637 1.22019901002824e-09 2.84986704208266 9.02670730756391e-19 miRanda -0.459631702070497 3.14853109893325e-09 NA NA NA hsa-miR-338-5p TTK -1.19659203838734 0.0100316010080496 2.84986704208266 9.02670730756391e-19 PITA -0.145745006686891 0.00679127492957799 NA NA NA hsa-miR-338-3p WEE1 -0.959276231066179 0.0191473351014091 -0.245078647266853 0.281035061897877 miRanda -0.111049496033606 0.00454625124208515 NA NA NA hsa-miR-218-5p YWHAB -0.987730614742492 0.0108295837207062 0.560953273192444 3.96438720523435e-05 MirTarget;miRNATAP -0.132643605810655 5.34245751955568e-08 NA NA NA hsa-miR-28-3p YWHAB -0.730670593501133 0.000351503999708671 0.560953273192444 3.96438720523435e-05 mirMAP -0.201074933049334 2.31268016134537e-05 NA NA NA hsa-miR-29b-2-5p YWHAE -1.7015307882027 2.84239251703401e-10 0.589666273640299 0.000303774555361019 MirTarget -0.283442585158459 6.04869989497828e-13 NA NA NA hsa-miR-30a-3p YWHAE -1.73205137750899 3.2425754511091e-07 0.589666273640299 0.000303774555361019 miRNAWalker2_validate;MirTarget;miRNATAP -0.122887316569407 0.000220217281793117 NA NA NA hsa-miR-30a-5p YWHAE -1.71922855140016 3.20574349285256e-07 0.589666273640299 0.000303774555361019 miRNAWalker2_validate -0.162000089779657 9.7810828573082e-07 NA NA NA hsa-miR-139-5p YWHAG -1.83374360776637 1.22019901002824e-09 0.786064999170599 8.42926791804072e-05 MirTarget;PITA;miRanda;miRNATAP -0.233897074977505 1.76624963351128e-07 NA NA NA hsa-miR-140-3p YWHAG -0.296251775392129 0.127539826012144 0.786064999170599 8.42926791804072e-05 MirTarget;PITA;miRNATAP -0.378974206830825 3.19734199541644e-07 NA NA NA hsa-miR-148a-3p YWHAG -1.53721533763578 3.55533747293117e-05 0.786064999170599 8.42926791804072e-05 mirMAP -0.207644440245434 1.84352771112896e-08 NA NA NA hsa-miR-148b-3p YWHAG 0.295175884456199 0.17466422420702 0.786064999170599 8.42926791804072e-05 mirMAP -0.185299344730775 0.00603097910246455 NA NA NA hsa-miR-181c-5p YWHAG 0.336826967681288 0.112932307913601 0.786064999170599 8.42926791804072e-05 MirTarget;miRNATAP -0.25588328816477 0.000187835020300278 NA NA NA hsa-miR-217 YWHAG -0.0121404731225336 0.980818372851502 0.786064999170599 8.42926791804072e-05 MirTarget;PITA;miRanda;miRNATAP -0.147034916555345 1.2228899839513e-07 NA NA NA hsa-miR-30a-5p YWHAG -1.71922855140016 3.20574349285256e-07 0.786064999170599 8.42926791804072e-05 miRNATAP -0.196811149472458 1.43906773606096e-06 NA NA NA hsa-miR-30b-5p YWHAG -0.430720743745757 0.0593564057320791 0.786064999170599 8.42926791804072e-05 miRNATAP -0.257903077785551 4.47785555025729e-05 NA NA NA hsa-miR-30c-5p YWHAG -0.983130268805942 4.60419218706127e-05 0.786064999170599 8.42926791804072e-05 miRNATAP -0.220075232527337 0.000185668060209576 NA NA NA hsa-miR-30d-5p YWHAG -0.5492586056147 0.0140125082460125 0.786064999170599 8.42926791804072e-05 miRNATAP -0.213526360715379 0.00100328280019275 NA NA NA hsa-miR-338-5p YWHAG -1.19659203838734 0.0100316010080496 0.786064999170599 8.42926791804072e-05 PITA;miRNATAP -0.11095194976889 0.000280249373758779 NA NA NA hsa-miR-361-3p YWHAG -0.126462931388735 0.566052688733137 0.786064999170599 8.42926791804072e-05 miRNATAP -0.282376760792372 1.74886615897343e-05 NA NA NA hsa-miR-500a-5p YWHAG 0.00337014556047865 0.992120109131868 0.786064999170599 8.42926791804072e-05 MirTarget;miRNATAP -0.183877094182199 1.09597495079572e-05 NA NA NA hsa-miR-625-3p YWHAG -0.185298294014366 0.626215541224408 0.786064999170599 8.42926791804072e-05 MirTarget -0.138559000351507 0.000237647988117345 NA NA NA hsa-let-7f-5p YWHAQ 0.634633924115866 0.0344982923411787 0.332508468080446 0.0893671775677139 miRNAWalker2_validate -0.135613273474918 0.00338792114275032 NA NA NA hsa-miR-139-5p YWHAQ -1.83374360776637 1.22019901002824e-09 0.332508468080446 0.0893671775677139 MirTarget;PITA;miRanda;miRNATAP -0.149575828728304 0.000675738998730082 NA NA NA hsa-miR-140-5p YWHAQ 0.208193069681326 0.303002433893804 0.332508468080446 0.0893671775677139 miRanda -0.247121691653543 0.00040094290892181 NA NA NA hsa-miR-195-5p YWHAQ -0.907998841926297 0.00150511564650591 0.332508468080446 0.0893671775677139 MirTarget;miRNATAP -0.172346531798579 0.000330508930253542 NA NA NA hsa-miR-497-5p YWHAQ -0.801030912431774 0.00360386743876612 0.332508468080446 0.0893671775677139 MirTarget;miRNATAP -0.190571360702168 0.000136707529898457 NA NA NA hsa-miR-125a-5p YWHAZ -0.878090699011564 0.000213630844319685 0.910846108792837 3.95356455522822e-05 miRanda -0.2963263935549 8.08143300917313e-06 NA NA NA hsa-miR-129-5p YWHAZ -2.56914016541176 2.36237896095709e-06 0.910846108792837 3.95356455522822e-05 miRanda -0.100589986472573 0.000512352503638405 NA NA NA hsa-miR-140-3p YWHAZ -0.296251775392129 0.127539826012144 0.910846108792837 3.95356455522822e-05 MirTarget;PITA;miRNATAP -0.485218364242567 2.60009968767316e-09 NA NA NA hsa-miR-195-3p YWHAZ -1.34779269408059 2.01619826639376e-05 0.910846108792837 3.95356455522822e-05 MirTarget -0.258353646708993 1.21967510972882e-07 NA NA NA hsa-miR-217 YWHAZ -0.0121404731225336 0.980818372851502 0.910846108792837 3.95356455522822e-05 miRanda -0.152196035725098 9.61806411845085e-07 NA NA NA hsa-miR-28-5p YWHAZ -0.238617853755144 0.167318538669818 0.910846108792837 3.95356455522822e-05 PITA;miRanda;miRNATAP -0.360580666571329 0.000148316235198698 NA NA NA hsa-miR-30a-5p YWHAZ -1.71922855140016 3.20574349285256e-07 0.910846108792837 3.95356455522822e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.289090361794288 6.87659241068155e-11 NA NA NA hsa-miR-30c-5p YWHAZ -0.983130268805942 4.60419218706127e-05 0.910846108792837 3.95356455522822e-05 MirTarget;miRNATAP -0.294131949452993 5.89454758802094e-06 24519092 Involvement of miR 30c in resistance to doxorubicin by regulating YWHAZ in breast cancer cells; Together our findings provided evidence that miR-30c was one of the important miRNAs in doxorubicin resistance by regulating YWHAZ in the breast cancer cell line MCF-7/ADR drug resistance breast cancer hsa-miR-30e-5p YWHAZ -0.573784818166736 0.0112497802572927 0.910846108792837 3.95356455522822e-05 MirTarget;miRNATAP -0.223629791120878 0.00170925393290396 NA NA NA hsa-miR-338-5p YWHAZ -1.19659203838734 0.0100316010080496 0.910846108792837 3.95356455522822e-05 mirMAP -0.116394082658444 0.000624841952889922 NA NA NA hsa-miR-340-3p YWHAZ -0.54276408676339 0.0739694056098475 0.910846108792837 3.95356455522822e-05 miRNAWalker2_validate -0.137139821904965 0.00968831074205658 NA NA NA hsa-miR-664a-3p YWHAZ -0.83041219170254 0.000136267547251167 0.910846108792837 3.95356455522822e-05 mirMAP -0.226096100567498 0.00210502900459849 NA NA NA