miRNA	gene	miRNA_log2FC	miRNA_pvalue	gene_log2FC	gene_pvalue	interactions	correlation_beta	correlation_pvalue	PMID	evidence	outcome	cancer
hsa-miR-34a-5p	ABHD2	0.129201805242403	0.133261654068224	0.450213534981843	0.000527417369441251	mirMAP	-0.123265010863648	0.018349951430513		NA	NA	NA
hsa-miR-34a-5p	ACSL4	0.129201805242403	0.133261654068224	-1.47773903295013	8.01517847091735e-37	miRNAWalker2_validate;MirTarget;miRNATAP	-0.108495513869246	0.0267693955962344		NA	NA	NA
hsa-miR-34a-5p	ADAM22	0.129201805242403	0.133261654068224	-1.22400577928345	9.86358971049703e-10	MirTarget;miRNATAP	-0.327154407279799	5.3319488768237e-05		NA	NA	NA
hsa-miR-34a-5p	ADCY1	0.129201805242403	0.133261654068224	-0.0486801025784516	0.841490665662841	mirMAP	-0.242406506512429	0.0130353925733776		NA	NA	NA
hsa-miR-34a-5p	ADNP	0.129201805242403	0.133261654068224	0.290689600961061	6.16201763521709e-05	miRNAWalker2_validate	-0.076572599994442	0.00868690941706002		NA	NA	NA
hsa-miR-34a-5p	AFAP1L2	0.129201805242403	0.133261654068224	-1.15376851508751	1.13039394747189e-19	miRNAWalker2_validate	-0.127651134382524	0.0144966391756509		NA	NA	NA
hsa-miR-34a-5p	AHNAK	0.129201805242403	0.133261654068224	-1.76535987346934	5.20116033627817e-56	miRNAWalker2_validate	-0.148753361821443	0.0020126364993857		NA	NA	NA
hsa-miR-34a-5p	AK3	0.129201805242403	0.133261654068224	-0.932751435603142	6.6847406780176e-45	MirTarget	-0.068252287914706	0.0152277594210522		NA	NA	NA
hsa-miR-34a-5p	AKAP13	0.129201805242403	0.133261654068224	-0.608726058300724	5.65488571630791e-18	mirMAP	-0.106975747301127	0.000200284025442049		NA	NA	NA
hsa-miR-34a-5p	AKAP6	0.129201805242403	0.133261654068224	-2.28015270926059	6.96245937007291e-60	MirTarget	-0.134956464157299	0.0256977219723797		NA	NA	NA
hsa-miR-34a-5p	ALX4	0.129201805242403	0.133261654068224	-3.21510012414237	4.06971831531578e-34	mirMAP	-0.46674886234663	2.27336264532142e-05		NA	NA	NA
hsa-miR-34a-5p	AMOTL2	0.129201805242403	0.133261654068224	-1.56594440622319	8.21783947483569e-62	MirTarget	-0.0884281996282688	0.0308500876343716		NA	NA	NA
hsa-miR-34a-5p	ANK2	0.129201805242403	0.133261654068224	-2.50568252042295	2.12750718019692e-56	MirTarget;miRNATAP	-0.316399585255762	3.20345722430936e-06		NA	NA	NA
hsa-miR-34a-5p	ANK3	0.129201805242403	0.133261654068224	-0.025345097787647	0.843322595909416	miRNATAP	-0.142764848247394	0.00546629790691742		NA	NA	NA
hsa-miR-34a-5p	ANKRD52	0.129201805242403	0.133261654068224	0.229691819057689	0.000236198445012247	miRNATAP	-0.050253813694484	0.045354524949576		NA	NA	NA
hsa-miR-34a-5p	ANKS1A	0.129201805242403	0.133261654068224	-0.367774669133925	3.05939471871311e-10	MirTarget	-0.100867636378822	1.84743227577203e-05		NA	NA	NA
hsa-miR-34a-5p	ARHGAP19	0.129201805242403	0.133261654068224	-0.973447425093666	1.02955194197712e-41	mirMAP	-0.113080874680019	0.000190783555299795		NA	NA	NA
hsa-miR-34a-5p	ARHGEF33	0.129201805242403	0.133261654068224	-0.658291874901687	5.33354315339066e-08	MirTarget	-0.102438216192709	0.0364230473447023		NA	NA	NA
hsa-miR-34a-5p	ARID4A	0.129201805242403	0.133261654068224	-0.85847003194558	2.64031635907732e-29	miRNATAP	-0.0734272629383302	0.0207313000060471		NA	NA	NA
hsa-miR-34a-5p	ASB1	0.129201805242403	0.133261654068224	-0.931546146396313	1.15209695972474e-50	MirTarget;miRNATAP	-0.0991623165471944	0.000183287911631521		NA	NA	NA
hsa-miR-34a-5p	ASTN1	0.129201805242403	0.133261654068224	-2.96085678510482	6.59267881470187e-30	MirTarget	-0.543233893086448	4.83146756119928e-07		NA	NA	NA
hsa-miR-34a-5p	ASXL2	0.129201805242403	0.133261654068224	-0.863091823045132	1.23718078543405e-08	MirTarget	-0.165946938464908	0.00682059949723894		NA	NA	NA
hsa-miR-34a-5p	ATAD2B	0.129201805242403	0.133261654068224	0.122127313389381	0.077302831927227	miRNATAP	-0.0624879189674498	0.0241145596047126		NA	NA	NA
hsa-miR-34a-5p	ATXN7	0.129201805242403	0.133261654068224	-0.518873129087427	1.54785837094948e-13	MirTarget;miRNATAP	-0.0678990512450136	0.0175682435039524		NA	NA	NA
hsa-miR-34a-5p	BAZ2A	0.129201805242403	0.133261654068224	-0.101133515135847	0.10090947960431	MirTarget;miRNATAP	-0.0648373734252353	0.00860408680584957		NA	NA	NA
hsa-miR-34a-5p	BCL2	0.129201805242403	0.133261654068224	-0.895845361347303	1.04475176246219e-07	miRNAWalker2_validate;miRTarBase	-0.21690891602483	0.00143015924808101	24565525;22623155;21399894;23155233;24444609;20687223;24988056;18803879;19714243;25053345;20433755;22964582;23862748	In vitro and in vivo experiments showed that miR-34a and DOX can be efficiently encapsulated into HA-CS NPs and delivered into tumor cells or tumor tissues and enhance anti-tumor effects of DOX by suppressing the expression of non-pump resistance and anti-apoptosis proto-oncogene Bcl-2;MiR 34a inhibits proliferation and migration of breast cancer through down regulation of Bcl 2 and SIRT1; In this study we aimed to determine the effect of miR-34a on the growth of breast cancer and to investigate whether its effect is achieved by targeting Bcl-2 and SIRT1; Bcl-2 and SIRT1 as the targets of miR-34a were found to be in reverse correlation with ectopic expression of miR-34a;Quantitative PCR and western analysis confirmed decreased expression of two genes BCL-2 and CCND1 in docetaxel-resistant cells which are both targeted by miR-34a;The miR-34a expression levels in cells after irradiation at 30 and 60 Gy were 0.17- and 18.7-times the BCL2 and caspase-9 expression levels respectively;Functional analyses further indicate that restoration of miR-34a inhibits B cell lymphoma-2 Bcl-2 protein expression to withdraw the survival advantage of these resistant NSCLC cells;Thus in PC3PR cells reduced expression of miR-34a confers paclitaxel resistance via up-regulating SIRT1 and Bcl2 expression; MiR-34a and its downstream targets SIRT1 and Bcl2 play important roles in the development of paclitaxel resistance all of which can be useful biomarkers and promising therapeutic targets for the drug resistance in hormone-refractory prostate cancer;Target analysis indicated that micro RNA miR-34a directly regulates Bcl-2 and miR-34a overexpression decreased Bcl-2 protein level in gastric cancer cells; We also found that luteolin upregulates miR-34a expression and downregulates Bcl-2 expression; Based on these results we can draw the conclusion that luteolin partly decreases Bcl-2 expression through upregulating miR-34a expression;miR-34 targets Notch HMGA2 and Bcl-2 genes involved in the self-renewal and survival of cancer stem cells; Human gastric cancer cells were transfected with miR-34 mimics or infected with the lentiviral miR-34-MIF expression system and validated by miR-34 reporter assay using Bcl-2 3'UTR reporter; Human gastric cancer Kato III cells with miR-34 restoration reduced the expression of target genes Bcl-2 Notch and HMGA2; Bcl-2 3'UTR reporter assay showed that the transfected miR-34s were functional and confirmed that Bcl-2 is a direct target of miR-34; The mechanism of miR-34-mediated suppression of self-renewal appears to be related to the direct modulation of downstream targets Bcl-2 Notch and HMGA2 indicating that miR-34 may be involved in gastric cancer stem cell self-renewal/differentiation decision-making;Among the target proteins regulated by miR-34 are Notch pathway proteins and Bcl-2 suggesting the possibility of a role for miR-34 in the maintenance and survival of cancer stem cells; Our data support the view that miR-34 may be involved in pancreatic cancer stem cell self-renewal potentially via the direct modulation of downstream targets Bcl-2 and Notch implying that miR-34 may play an important role in pancreatic cancer stem cell self-renewal and/or cell fate determination;Manipulating miR-34a in prostate cancer cells confirms that this miRNA regulates BCL-2 and may in part regulate response to docetaxel;For instance miR-34a up-regulation corresponded with a down-regulation of BCL2 protein; Treating Par-4-overexpressing HT29 cells with a miR-34a antagomir functionally reversed both BCL2 down-regulation and apoptosis by 5-FU;Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;MicroRNA 34a targets Bcl 2 and sensitizes human hepatocellular carcinoma cells to sorafenib treatment; HCC tissues with lower miR-34a expression displayed higher expression of Bcl-2 protein than those with high expression of miR-34a; therefore an inverse correlation is evident between the miR-34a level and Bcl-2 expression; Bioinformatics and luciferase reporter assays revealed that miR-34a binds the 3'-UTR of the Bcl-2 mRNA and represses its translation; Western blotting analysis and qRT-PCR confirmed that Bcl-2 is inhibited by miR-34a overexpression; Functional analyses indicated that the restoration of miR-34a reduced cell viability promoted cell apoptosis and potentiated sorafenib-induced apoptosis and toxicity in HCC cell lines by inhibiting Bcl-2 expression	drug resistance;;;;poor survival;drug resistance;;poor survival;differentiation;poor survival;drug resistance;;;	breast cancer;breast cancer;breast cancer;glioblastoma;lung squamous cell cancer;prostate cancer;gastric cancer;gastric cancer;pancreatic cancer;prostate cancer;colon cancer;lung cancer;liver cancer
hsa-miR-34a-5p	BCLAF1	0.129201805242403	0.133261654068224	-0.265122103562321	5.48932917512334e-06	miRNAWalker2_validate	-0.0587391910681024	0.0123252047787052		NA	NA	NA
hsa-miR-34a-5p	BIRC6	0.129201805242403	0.133261654068224	-0.313518003308769	0.000102931684498142	miRNAWalker2_validate	-0.0709072785028159	0.0290850143930257		NA	NA	NA
hsa-miR-34a-5p	BNC2	0.129201805242403	0.133261654068224	-0.776172590713737	2.35134421190691e-07	miRNATAP	-0.1268055943999	0.0367557464987537		NA	NA	NA
hsa-miR-34a-5p	BRPF3	0.129201805242403	0.133261654068224	0.0924754751249477	0.205867037581768	MirTarget;miRNATAP	-0.1208354829057	3.47354304224124e-05		NA	NA	NA
hsa-miR-34a-5p	C17orf51	0.129201805242403	0.133261654068224	-1.38118393054696	1.19626145693611e-32	mirMAP	-0.175978121743166	0.000276078584299147		NA	NA	NA
hsa-miR-34a-5p	C1orf21	0.129201805242403	0.133261654068224	-0.468027970401431	0.00105985509741778	mirMAP	-0.146789936851505	0.0106726366586181		NA	NA	NA
hsa-miR-34a-5p	CACHD1	0.129201805242403	0.133261654068224	-2.56774598917352	6.13969823521877e-72	MirTarget	-0.377096637267684	1.48795228140549e-09		NA	NA	NA
hsa-miR-34a-5p	CAMSAP1	0.129201805242403	0.133261654068224	-0.100397359571622	0.0863933364369177	miRNATAP	-0.0683327435741333	0.00352629994070425		NA	NA	NA
hsa-miR-34a-5p	CAPN6	0.129201805242403	0.133261654068224	-3.62270638284474	1.23690757569109e-25	miRNATAP	-0.804251252102527	1.57851882946847e-08		NA	NA	NA
hsa-miR-34a-5p	CAPRIN1	0.129201805242403	0.133261654068224	0.340943091770461	1.37022843842e-07	miRNAWalker2_validate	-0.0874822017913324	0.00079040720471009		NA	NA	NA
hsa-miR-34a-5p	CCDC50	0.129201805242403	0.133261654068224	-1.32804358916198	4.78202111890448e-88	miRNATAP	-0.109182111297098	0.000253881924367025		NA	NA	NA
hsa-miR-34a-5p	CDKN1C	0.129201805242403	0.133261654068224	-2.10696277121193	3.07611963088364e-54	miRNATAP	-0.278255101538641	1.67359419187959e-06		NA	NA	NA
hsa-miR-34a-5p	CDKN2AIP	0.129201805242403	0.133261654068224	-0.394680655814815	8.46841394609879e-11	miRNAWalker2_validate	-0.0580703520431844	0.0183811056129435		NA	NA	NA
hsa-miR-34a-5p	CDKN2C	0.129201805242403	0.133261654068224	-1.07930959319688	4.54026994590945e-24	miRNAWalker2_validate	-0.0931151100313197	0.0346168725273831		NA	NA	NA
hsa-miR-34a-5p	CDON	0.129201805242403	0.133261654068224	-0.991164686357028	8.70119211480039e-13	miRNAWalker2_validate	-0.131340195671336	0.0199571757499009		NA	NA	NA
hsa-miR-34a-5p	CELF2	0.129201805242403	0.133261654068224	-2.12375294826078	1.08191631254129e-58	miRNATAP	-0.14087090572291	0.0131749190290747		NA	NA	NA
hsa-miR-34a-5p	CEP170	0.129201805242403	0.133261654068224	-0.107111846974417	0.229621080260684	miRNAWalker2_validate	-0.0741542499328554	0.0380880273095575		NA	NA	NA
hsa-miR-34a-5p	CHM	0.129201805242403	0.133261654068224	-0.435590455256697	1.04154540530281e-07	MirTarget	-0.0911714658223523	0.00582049472212388		NA	NA	NA
hsa-miR-34a-5p	CLOCK	0.129201805242403	0.133261654068224	-0.444410941110669	0.00108938309187277	MirTarget	-0.109730493000938	0.045076156706621		NA	NA	NA
hsa-miR-34a-5p	CNTN2	0.129201805242403	0.133261654068224	-1.15456712353161	6.34768185707336e-07	MirTarget;miRNATAP	-0.267075477231993	0.00432985007920852		NA	NA	NA
hsa-miR-34a-5p	CPEB2	0.129201805242403	0.133261654068224	-0.298345623194636	0.0154801715002403	miRNATAP	-0.0992857839620485	0.0449694475897206		NA	NA	NA
hsa-miR-34a-5p	CR2	0.129201805242403	0.133261654068224	-0.576401573338542	0.120604799224487	MirTarget	-0.329565652484468	0.0270986819903784		NA	NA	NA
hsa-miR-34a-5p	CRTC1	0.129201805242403	0.133261654068224	0.0277799605736115	0.71582661557579	miRNATAP	-0.070720838662054	0.0206839387679924		NA	NA	NA
hsa-miR-34a-5p	CRY2	0.129201805242403	0.133261654068224	-1.19975346543936	7.77211531373058e-53	MirTarget	-0.132776221675905	7.43045047630975e-05		NA	NA	NA
hsa-miR-34a-5p	CTDSP2	0.129201805242403	0.133261654068224	-0.729241442292955	1.0301540254669e-37	miRNATAP	-0.144369811542568	9.8114231309258e-10		NA	NA	NA
hsa-miR-34a-5p	CTNNB1	0.129201805242403	0.133261654068224	-0.339832485209634	2.23758599550069e-07	miRNAWalker2_validate	-0.0614881341139617	0.0202164418517387		NA	NA	NA
hsa-miR-34a-5p	DAPK2	0.129201805242403	0.133261654068224	-1.02689963252696	7.98595973064237e-21	MirTarget	-0.103311672951104	0.022071212564172	27704360	E2F 1 promotes DAPK2 induced anti tumor immunity of gastric cancer cells by targeting miR 34a		gastric cancer
hsa-miR-34a-5p	DCX	0.129201805242403	0.133261654068224	-2.74666176017894	1.23860367619362e-14	MirTarget;miRNATAP	-0.677910727957364	2.80286155979283e-06		NA	NA	NA
hsa-miR-34a-5p	DDAH2	0.129201805242403	0.133261654068224	0.194938806796172	0.0399860132527582	miRNAWalker2_validate	-0.0767416262845975	0.0439989188127483		NA	NA	NA
hsa-miR-34a-5p	DIXDC1	0.129201805242403	0.133261654068224	-1.64219180882631	5.60950919042518e-55	MirTarget	-0.0908499011705898	0.0446590091982152		NA	NA	NA
hsa-miR-34a-5p	DLL1	0.129201805242403	0.133261654068224	-0.947678753705407	5.16495496029924e-14	miRNAWalker2_validate;miRTarBase;miRNATAP	-0.184988188274597	0.000303752133199536	22438124	Delta tocotrienol suppresses Notch 1 pathway by upregulating miR 34a in nonsmall cell lung cancer cells		lung squamous cell cancer
hsa-miR-34a-5p	DNMBP	0.129201805242403	0.133261654068224	-0.666936518001947	1.27257555078449e-08	MirTarget	-0.0964805621948879	0.0420944464075427		NA	NA	NA
hsa-miR-34a-5p	EDAR	0.129201805242403	0.133261654068224	-2.78657132772223	2.4195664655362e-25	miRNATAP	-0.45630012879257	3.66299418319983e-05		NA	NA	NA
hsa-miR-34a-5p	EEA1	0.129201805242403	0.133261654068224	-0.917079076269	8.13513862826476e-26	miRNATAP	-0.0765001169113725	0.0342665654989881		NA	NA	NA
hsa-miR-34a-5p	EFNB3	0.129201805242403	0.133261654068224	-1.46127308517026	6.88852125012967e-17	miRNATAP	-0.219660735842772	0.00214695851967333		NA	NA	NA
hsa-miR-34a-5p	EPB41L2	0.129201805242403	0.133261654068224	-1.76480491649636	1.15237907583462e-57	miRNAWalker2_validate	-0.179456739687866	0.000156339363206854		NA	NA	NA
hsa-miR-34a-5p	EPHA4	0.129201805242403	0.133261654068224	-1.55269305526411	1.14762781890163e-27	miRNATAP	-0.152603351130788	0.00984692330091796		NA	NA	NA
hsa-miR-34a-5p	ERC1	0.129201805242403	0.133261654068224	-0.360248736264644	4.26949272667695e-07	mirMAP;miRNATAP	-0.145133180353668	3.7825165506858e-07		NA	NA	NA
hsa-miR-34a-5p	EVC	0.129201805242403	0.133261654068224	-0.696684919412769	3.38576866916321e-10	mirMAP	-0.109718822282259	0.0147356561413346		NA	NA	NA
hsa-miR-34a-5p	EXT2	0.129201805242403	0.133261654068224	-0.0773525169176104	0.156511127759975	miRNAWalker2_validate	-0.0510213507510728	0.0194884802918916		NA	NA	NA
hsa-miR-34a-5p	F2RL2	0.129201805242403	0.133261654068224	1.83288694519631	1.27552904921777e-14	MirTarget;miRNATAP	-0.273962671456491	0.00473709403031966		NA	NA	NA
hsa-miR-34a-5p	FAM117B	0.129201805242403	0.133261654068224	0.0604096747081551	0.39180010839393	MirTarget	-0.130922910879068	3.21697282063869e-06		NA	NA	NA
hsa-miR-34a-5p	FAM126B	0.129201805242403	0.133261654068224	-0.47592775622376	8.08751743843368e-12	miRNATAP	-0.0580627407006096	0.039975313450239		NA	NA	NA
hsa-miR-34a-5p	FAM168A	0.129201805242403	0.133261654068224	-0.595647286022841	1.59492655064768e-06	mirMAP	-0.190220225413009	0.000141052431104075		NA	NA	NA
hsa-miR-34a-5p	FAM53B	0.129201805242403	0.133261654068224	0.268092446059919	0.00126200740360576	mirMAP	-0.159237445795523	1.66425721694019e-06		NA	NA	NA
hsa-miR-34a-5p	FAT3	0.129201805242403	0.133261654068224	-1.39927804148844	8.16110526253237e-11	miRNATAP	-0.184590017486928	0.0348852794089329		NA	NA	NA
hsa-miR-34a-5p	FAT4	0.129201805242403	0.133261654068224	-2.33360300758631	3.89695808711231e-45	MirTarget	-0.354502862980423	3.95531561333971e-07		NA	NA	NA
hsa-miR-34a-5p	FIGN	0.129201805242403	0.133261654068224	-2.43971791427329	1.33964701286684e-33	miRNAWalker2_validate	-0.203210028809886	0.016206486232265		NA	NA	NA
hsa-miR-34a-5p	FOXJ2	0.129201805242403	0.133261654068224	-0.393198614292539	6.26293449551835e-15	MirTarget;miRNATAP	-0.0856063724014223	2.81096856858298e-05		NA	NA	NA
hsa-miR-34a-5p	FOXK1	0.129201805242403	0.133261654068224	-0.349044780616968	7.57441065964192e-06	mirMAP	-0.108150934072414	0.000562305987891919		NA	NA	NA
hsa-miR-34a-5p	FOXN3	0.129201805242403	0.133261654068224	-1.6997111136462	5.59981199956681e-76	miRNATAP	-0.187958471703313	3.48422336957395e-06		NA	NA	NA
hsa-miR-34a-5p	FRMD4A	0.129201805242403	0.133261654068224	-1.01645361935313	1.41995569982009e-35	MirTarget	-0.0968128727863045	0.0046395662757851		NA	NA	NA
hsa-miR-34a-5p	GAB1	0.129201805242403	0.133261654068224	-0.692166188366933	9.18798859765721e-16	MirTarget	-0.0805687728281127	0.0219752509109193		NA	NA	NA
hsa-miR-34a-5p	GDPD5	0.129201805242403	0.133261654068224	-1.42259476027658	2.71926623796958e-27	mirMAP	-0.129883733557081	0.0172594516570271		NA	NA	NA
hsa-miR-34a-5p	GFRA1	0.129201805242403	0.133261654068224	-0.692412159332901	0.064695425447951	miRNATAP	-0.661941166368614	1.00749540653096e-05		NA	NA	NA
hsa-miR-34a-5p	GIGYF2	0.129201805242403	0.133261654068224	-0.190745976585633	0.000533637047697426	miRNAWalker2_validate	-0.0594349795948669	0.00713180931932558		NA	NA	NA
hsa-miR-34a-5p	GLCE	0.129201805242403	0.133261654068224	-0.00567847588405623	0.955049108399326	MirTarget;miRNATAP	-0.0899061136955374	0.0260035559676501		NA	NA	NA
hsa-miR-34a-5p	GPR156	0.129201805242403	0.133261654068224	-0.926380335525025	2.77393738091549e-05	MirTarget	-0.192265358661685	0.0310317570172907		NA	NA	NA
hsa-miR-34a-5p	GREM2	0.129201805242403	0.133261654068224	-2.65211306689938	8.60704393228989e-30	MirTarget;miRNATAP	-0.19613198018317	0.0442019730288402		NA	NA	NA
hsa-miR-34a-5p	GRID1	0.129201805242403	0.133261654068224	-1.26594797560263	4.62889296276057e-22	miRNATAP	-0.230596744736542	1.83247523511362e-05		NA	NA	NA
hsa-miR-34a-5p	HIC2	0.129201805242403	0.133261654068224	-0.30171087568962	2.68519567970826e-05	mirMAP	-0.124367007974165	1.58611723413437e-05		NA	NA	NA
hsa-miR-34a-5p	HIPK2	0.129201805242403	0.133261654068224	-0.953765945586234	3.35720241682395e-14	mirMAP	-0.163108295086776	0.00144966864946411		NA	NA	NA
hsa-miR-34a-5p	HNRNPUL1	0.129201805242403	0.133261654068224	0.257759440685283	1.59939537254825e-09	miRNAWalker2_validate	-0.0596691254084084	0.000519575074590576		NA	NA	NA
hsa-miR-34a-5p	IGF2	0.129201805242403	0.133261654068224	-1.80707502143834	9.64580354953106e-21	mirMAP	-0.242484753846277	0.00229621728593982		NA	NA	NA
hsa-miR-34a-5p	IGFBP5	0.129201805242403	0.133261654068224	-0.624288440197653	0.00100115978565398	mirMAP	-0.17302633015973	0.0234603470026858		NA	NA	NA
hsa-miR-34a-5p	IGSF3	0.129201805242403	0.133261654068224	0.889266392741621	3.34886421336615e-15	MirTarget	-0.100778847922227	0.0288177663105811		NA	NA	NA
hsa-miR-34a-5p	ING5	0.129201805242403	0.133261654068224	-0.237265481897531	0.000243359848640052	mirMAP	-0.100801887813945	0.000100097080391815		NA	NA	NA
hsa-miR-34a-5p	ITPKB	0.129201805242403	0.133261654068224	-0.460580394185294	4.22060681622517e-09	mirMAP	-0.0904391106569017	0.00432833150426273		NA	NA	NA
hsa-miR-34a-5p	ITPR2	0.129201805242403	0.133261654068224	-0.979435994319307	6.70245773649528e-14	MirTarget	-0.181215796033106	0.000656619695493269		NA	NA	NA
hsa-miR-34a-5p	ITSN1	0.129201805242403	0.133261654068224	-1.54952456784757	2.98389839982187e-72	mirMAP	-0.120412856845002	0.00146044818350177		NA	NA	NA
hsa-miR-34a-5p	JAG1	0.129201805242403	0.133261654068224	-0.639848689982383	1.267264807356e-11	miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP	-0.109741827165887	0.00421467997130295		NA	NA	NA
hsa-miR-34a-5p	JMJD1C	0.129201805242403	0.133261654068224	-0.953909284202117	8.88053084204105e-27	miRNATAP	-0.0993955281976969	0.00703803407983777		NA	NA	NA
hsa-miR-34a-5p	JRK	0.129201805242403	0.133261654068224	-0.401467963428249	5.66932663917061e-06	MirTarget	-0.0957171541533427	0.0072468338020432		NA	NA	NA
hsa-miR-34a-5p	KBTBD6	0.129201805242403	0.133261654068224	-0.650214766705834	1.42503592185711e-20	miRNAWalker2_validate	-0.0776993713627357	0.00678841467212835		NA	NA	NA
hsa-miR-34a-5p	KCNA1	0.129201805242403	0.133261654068224	-2.92558361314474	6.5800868813974e-30	miRNATAP	-0.592000158273979	2.69700972123137e-08		NA	NA	NA
hsa-miR-34a-5p	KCNQ4	0.129201805242403	0.133261654068224	-2.00601887339821	2.87129859849754e-16	mirMAP	-0.313373896411856	0.00176720005825768		NA	NA	NA
hsa-miR-34a-5p	KIAA1462	0.129201805242403	0.133261654068224	-0.894733095554471	4.07536183567301e-18	MirTarget	-0.128596684929979	0.00231551614145778		NA	NA	NA
hsa-miR-34a-5p	KIT	0.129201805242403	0.133261654068224	-3.55980779277124	2.17700605158782e-58	MirTarget	-0.444920568628705	2.86104030251141e-06		NA	NA	NA
hsa-miR-34a-5p	KITLG	0.129201805242403	0.133261654068224	-0.144677358802896	0.348643719752218	MirTarget	-0.193013612056888	0.00180458841369172		NA	NA	NA
hsa-miR-34a-5p	KLB	0.129201805242403	0.133261654068224	-4.39501154494066	7.99875073016999e-95	miRNAWalker2_validate;miRTarBase	-0.22882007040995	0.0174830170912026		NA	NA	NA
hsa-miR-34a-5p	KLF13	0.129201805242403	0.133261654068224	-0.896526705579424	4.61689653388107e-25	mirMAP	-0.132063949879385	0.000221408209408011		NA	NA	NA
hsa-miR-34a-5p	KLF4	0.129201805242403	0.133261654068224	-2.5658507723861	1.98241408884064e-67	MirTarget;miRNATAP	-0.158656084881947	0.0141218354001629		NA	NA	NA
hsa-miR-34a-5p	KLF7	0.129201805242403	0.133261654068224	-0.960860641075609	9.39965862664561e-13	miRNATAP	-0.157361355542325	0.00404647264448548		NA	NA	NA
hsa-miR-34a-5p	KLHDC3	0.129201805242403	0.133261654068224	0.170722781041563	0.0238075325033972	MirTarget	-0.0666635408234364	0.0278155214531707		NA	NA	NA
hsa-miR-34a-5p	LGR4	0.129201805242403	0.133261654068224	-1.80154760191776	1.78479409180551e-31	MirTarget;miRNATAP	-0.172246404445712	0.00746567112883859		NA	NA	NA
hsa-miR-34a-5p	LRCH1	0.129201805242403	0.133261654068224	-0.845603029773804	1.79105003827433e-30	MirTarget	-0.0906481283245755	0.00309489623241339		NA	NA	NA
hsa-miR-34a-5p	LRP4	0.129201805242403	0.133261654068224	-1.80859309249455	1.72412102466362e-32	MirTarget	-0.252583788665433	6.92692090709297e-05		NA	NA	NA
hsa-miR-34a-5p	LRRC40	0.129201805242403	0.133261654068224	-0.183676655831174	0.00762025135844523	miRNAWalker2_validate;MirTarget	-0.0630040671261562	0.0225326413529393		NA	NA	NA
hsa-miR-34a-5p	LRRC55	0.129201805242403	0.133261654068224	0.603661961522672	7.29925788586255e-05	MirTarget;miRNATAP	-0.254801052927525	3.05179477936503e-05		NA	NA	NA
hsa-miR-34a-5p	MAGI1	0.129201805242403	0.133261654068224	-1.26305301454899	4.04392522280675e-34	miRNAWalker2_validate	-0.138169684057071	0.00143591501354134		NA	NA	NA
hsa-miR-34a-5p	MBP	0.129201805242403	0.133261654068224	-1.05743986242831	1.70792931878289e-20	mirMAP	-0.129122802466568	0.00582557560713221		NA	NA	NA
hsa-miR-34a-5p	MCF2L	0.129201805242403	0.133261654068224	-0.0239497219177798	0.811879517213897	mirMAP	-0.0946976893763795	0.0188861507684321		NA	NA	NA
hsa-miR-34a-5p	MCTP1	0.129201805242403	0.133261654068224	-1.60151272020006	4.27309943958378e-26	miRNATAP	-0.232973777542527	0.00020028830609678		NA	NA	NA
hsa-miR-34a-5p	MDM4	0.129201805242403	0.133261654068224	0.113166606771184	0.0960960367986367	miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP	-0.0784307505415401	0.00396555195665231		NA	NA	NA
hsa-miR-34a-5p	MECP2	0.129201805242403	0.133261654068224	-0.461019995437165	5.63618149586866e-20	mirMAP	-0.0719677812523935	0.000474490973700191		NA	NA	NA
hsa-miR-34a-5p	MET	0.129201805242403	0.133261654068224	-2.36906628256571	5.79970002931919e-38	miRNAWalker2_validate;miRTarBase	-0.260533934700572	0.00074892552882336	23243217;26104764;22457788;23593387;19006648;19773441;19029026	Detection of miR 34a promoter methylation in combination with elevated expression of c Met and β catenin predicts distant metastasis of colon cancer; Using a case-control study design of 94 primary colon cancer samples with and without liver metastases we determined CpG methylation frequencies of miR-34a and miR-34b/c promoters expression of miR-34a and its targets c-Met Snail and β-catenin and their prognostic value; Decreased miR-34a expression was associated with upregulation of c-Met Snail and β-catenin protein levels P = 0.031 0.132 and 0.004 which were associated with distant metastases P = 0.001 0.017 and 0.005; In a confounder-adjusted multivariate regression model miR-34a methylation high c-Met and β-catenin levels provided the most significant prognostic information about metastases to the liver P = 0.014 0.031 and 0.058 and matched pairs showed a higher prevalence of these risk factors in the samples with distant spread P = 0.029; Silencing of miR-34a and upregulation of c-Met Snail and β-catenin expression is associated with liver metastases of colon cancer; Detection of miR-34a silencing in resected primary colon cancer may be of prognostic value especially in combination with detection of c-Met and β-catenin expression;The expression of microRNA 34a is inversely correlated with c MET and CDK6 and has a prognostic significance in lung adenocarcinoma patients; We found significant inverse correlations between miR-34a and c-MET R = -0.316 P = 0.028 and CDK6 expression R = -0.4582 P = 0.004;c-Met is a target of miR-34a and regulates the migration and invasion of osteosarcoma cells; Osteosarcoma cells over-expressing miR-34a exhibited a significant decrease in the expression levels of c-Met mRNA and protein simultaneously; The results presented in this study demonstrated that over-expression of miR-34a could inhibit the tumor growth and metastasis of osteosarcoma probably through down regulating c-Met; And there are other putative miR-34a target genes beside c-Met which could potentially be key players in the development of osteosarcoma;Underexpression of miR 34a in hepatocellular carcinoma and its contribution towards enhancement of proliferating inhibitory effects of agents targeting c MET; In addition miR-34a mimic enhanced the effect of cell proliferation inhibition and caspase activity induction of agents targeting c-MET siRNAs and small molecular inhibitor su11274;miR 34a inhibits migration and invasion by down regulation of c Met expression in human hepatocellular carcinoma cells; miR-34a directly targeted c-Met and reduced both mRNA and protein levels of c-Met; thus decreased c-Met-induced phosphorylation of extracellular signal-regulated kinases 1 and 2 ERK1/2; Taken together these results provide evidence to show the suppression role of miR-34a in tumor migration and invasion through modulation of the c-Met signaling pathway;miR-34a levels in human gliomas inversely correlated to c-Met levels measured in the same tumors; Forced expression of c-Met or Notch-1/Notch-2 transcripts lacking the 3'-untranslated region sequences partially reversed the effects of miR-34a on cell cycle arrest and cell death in glioma cells and stem cells respectively; They show that miR-34a suppresses brain tumor growth by targeting c-Met and Notch;MicroRNA 34a inhibits uveal melanoma cell proliferation and migration through downregulation of c Met; In addition expression of c-Met and cell cycle-related proteins was determined by Western blotting and immunofluorescence after the introduction of miR-34a miR-34a is actively expressed in melanocytes but not in uveal melanoma cells based on Northern blot analysis; After identification of two putative miR-34a binding sites within the 3' UTR of the human c-Met mRNA miR-34a was shown to suppress luciferase activity using HEK293 cells with a luciferase reporter construct containing the binding sites; miR-34a was confirmed to downregulate the expression of c-Met protein by Western blotting and immunofluorescence; These results demonstrate that miR-34a acts as a tumor suppressor in uveal melanoma cell proliferation and migration through the downregulation of c-Met	metastasis;;metastasis;;;;	colon cancer;lung cancer;sarcoma;liver cancer;liver cancer;glioblastoma;melanoma
hsa-miR-34a-5p	MEX3C	0.129201805242403	0.133261654068224	-0.505142039973927	2.97218862608741e-11	MirTarget	-0.0696947724411328	0.023809439636111		NA	NA	NA
hsa-miR-34a-5p	MLC1	0.129201805242403	0.133261654068224	-0.00602240290377876	0.981829799025522	mirMAP	-0.424270151254683	6.02456206498475e-05		NA	NA	NA
hsa-miR-34a-5p	MLLT3	0.129201805242403	0.133261654068224	-0.378104133164759	0.00143669597198025	MirTarget;miRNATAP	-0.0969651438169054	0.0421905567469744		NA	NA	NA
hsa-miR-34a-5p	MON2	0.129201805242403	0.133261654068224	-0.531742758397095	8.92863225323636e-16	MirTarget	-0.0620992510207922	0.0213612559320255		NA	NA	NA
hsa-miR-34a-5p	MSL2	0.129201805242403	0.133261654068224	-0.189656760551145	0.000116747366272169	MirTarget;miRNATAP	-0.0705054852946464	0.000347305114642234		NA	NA	NA
hsa-miR-34a-5p	MTMR9	0.129201805242403	0.133261654068224	-0.632252261815016	1.3345727353147e-18	miRNAWalker2_validate	-0.0593287167978149	0.0438488637930852		NA	NA	NA
hsa-miR-34a-5p	MYADM	0.129201805242403	0.133261654068224	-0.976381468148222	5.12624595262159e-29	MirTarget	-0.0744512997634762	0.0403259453077189		NA	NA	NA
hsa-miR-34a-5p	MYC	0.129201805242403	0.133261654068224	-1.13124656428776	3.22608205108151e-16	miRNAWalker2_validate;miRTarBase	-0.216308870548993	0.000129276161670072	25572695;25686834;21460242;22159222;23640973;22830357;22235332	The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;miR 34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c Myc pathway;Myc mediated repression of microRNA 34a promotes high grade transformation of B cell lymphoma by dysregulation of FoxP1;MicroRNA 34a suppresses malignant transformation by targeting c Myc transcriptional complexes in human renal cell carcinoma; We investigated the functional effects of microRNA-34a miR-34a on c-Myc transcriptional complexes in renal cell carcinoma; miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region which was revealed by luciferase reporter assays; Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription indicating a novel role of miR-34a in the regulation of transcription by c-Myc;Among them miR-34a was also associated with poor prognosis in 2 independent series of leukemic and nodal MCL and in cooperation with high expression of the MYC oncogene;We report that miR-34a did not inhibit cell proliferation notwithstanding a marked down-regulation of c-MYC;MicroRNA 34a modulates c Myc transcriptional complexes to suppress malignancy in human prostate cancer cells; We studied the functional effects of miR-34a on c-Myc transcriptional complexes in PC-3 prostate cancer cells; miR-34a downregulated expression of c-Myc oncogene by targeting its 3' UTR as shown by luciferase reporter assays; This is the first report to document that miR-34a suppresses assembly and function of the c-Myc-Skp2-Miz1 complex that activates RhoA and the c-Myc-pTEFB complex that elongates transcription of various genes suggesting a novel role of miR-34a in the regulation of transcription by c-Myc complex	;;;malignant trasformation;worse prognosis;;	bladder cancer;liver cancer;B cell lymphoma;kidney renal cell cancer;lymphoma;lymphoma;prostate cancer
hsa-miR-34a-5p	MYNN	0.129201805242403	0.133261654068224	-0.145679411811862	0.00944449434195857	MirTarget	-0.0536865894868763	0.0169752497041215		NA	NA	NA
hsa-miR-34a-5p	MYRIP	0.129201805242403	0.133261654068224	-2.17370145905386	1.8691130119275e-20	miRNATAP	-0.531237009913779	2.89043646633229e-08		NA	NA	NA
hsa-miR-34a-5p	NAP1L5	0.129201805242403	0.133261654068224	-1.09993598867014	5.12983053371275e-25	miRNATAP	-0.116263799019501	0.00825877505443093		NA	NA	NA
hsa-miR-34a-5p	NAT8L	0.129201805242403	0.133261654068224	-2.93784052922262	7.82426389917244e-41	MirTarget	-0.29895802749646	0.00125022613036032		NA	NA	NA
hsa-miR-34a-5p	NAV3	0.129201805242403	0.133261654068224	-1.78347027501907	7.45924181306669e-19	MirTarget	-0.183656351727409	0.0261329677805879		NA	NA	NA
hsa-miR-34a-5p	NCDN	0.129201805242403	0.133261654068224	1.04352826113288	7.73961476830205e-35	MirTarget	-0.0908550260252588	0.0104458219785321		NA	NA	NA
hsa-miR-34a-5p	NCOR2	0.129201805242403	0.133261654068224	0.252388985973358	7.05336186529347e-05	MirTarget	-0.0799978911075696	0.00170579731452234		NA	NA	NA
hsa-miR-34a-5p	NDST1	0.129201805242403	0.133261654068224	-0.622870054013256	1.51055434858535e-18	MirTarget;miRNATAP	-0.0731662573039047	0.0116987425781189		NA	NA	NA
hsa-miR-34a-5p	NFIC	0.129201805242403	0.133261654068224	-0.323552442007893	0.00148597690443502	mirMAP	-0.11905578972851	0.0036063142131713		NA	NA	NA
hsa-miR-34a-5p	NGFR	0.129201805242403	0.133261654068224	-2.50042294481334	5.32154099004444e-27	mirMAP	-0.493588136203429	2.5977817562076e-07		NA	NA	NA
hsa-miR-34a-5p	NNT	0.129201805242403	0.133261654068224	-0.328696312785028	0.00101961894282938	miRNAWalker2_validate	-0.104869192236743	0.00912053486943876		NA	NA	NA
hsa-miR-34a-5p	NOS1AP	0.129201805242403	0.133261654068224	-0.675518736834807	0.00068091520217485	miRNATAP	-0.338867031783773	2.14186250461068e-05		NA	NA	NA
hsa-miR-34a-5p	NOTCH1	0.129201805242403	0.133261654068224	-0.553015677374277	2.02877481257167e-09	miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP	-0.0815051455531308	0.0291665501612734	24565525;25783790;27082152;25623761;23085450;22438124;23140286;24349627;20351093;23642368;22347519;23430952;23902763;21743299;22992310;23145211	In addition intracellular restoration of miR-34a inhibited breast cancer cell migration via targeting Notch-1 signaling;MicroRNA 34a suppresses the breast cancer stem cell like characteristics by downregulating Notch1 pathway; In this study we verified that miR-34a directly and functionally targeted Notch1 in MCF-7 cells; We reported that miR-34a negatively regulated cell proliferation migration and invasion and breast cancer stem cell propagation by downregulating Notch1; The expression of miR-34a was negatively correlated with tumor stages metastasis and Notch1 expression in breast cancer tissues; Furthermore overexpression of miR-34a increased chemosensitivity of breast cancer cells to paclitaxel PTX by downregulating the Notch1 pathway; Taken together our results indicate that miR-34a inhibited breast cancer stemness and increased the chemosensitivity to PTX partially by downregulating the Notch1 pathway suggesting that miR-34a/Notch1 play an important role in regulating breast cancer stem cells;We showed that miR-34a as a tumor suppressor could separately reduce the stemness of BCSCs and activate the cytotoxic susceptibility of BCSCs to natural killer NK cells in vitro via down regulating the expression of Notch1 signaling molecules;miR 34a may regulate sensitivity of breast cancer cells to adriamycin via targeting Notch1; To explore the influence of miR-34a on Notch1 expression in breast cancer cells and to explore the role of miR-34a in the sensitivity of breast cancer cells to Adriamycin ADR; The expression levels of Notch1 mRNA and protein in MCF-7/ADR cells transfected with miR-34a mimics were significantly up-regulated; On the contrary the expressions of Notch1 mRNA and protein in MCF-7 cells transfected with miR-34a inhibitor were down-regulated; miR-34a negatively regulates the expression of Notch1 at both mRNA and protein levels;MicroRNA 34a modulates chemosensitivity of breast cancer cells to adriamycin by targeting Notch1; The association of miR-34a and Notch1 was analyzed by dual-luciferase reporter assay and Notch1-siRNA technology; Real-time PCR assay was performed to test the expression of miR-34a and Notch1 in 38 selective breast cancer tissue samples; MiR-34a mimic could inhibit the luciferase activity of the construct containing wild-type 3' UTR of Notch1 in MCF-7/ADR cells; Further there was an inverse association between Notch1 and miR-34a expression in breast cancer; Dysregulation of miR-34a plays critical roles in the acquired ADR resistance of breast cancer at least in part via targeting Notch1;Delta tocotrienol suppresses Notch 1 pathway by upregulating miR 34a in nonsmall cell lung cancer cells; In our study using miRNA microarray we observed that downregulation of the Notch-1 pathway by delta-tocotrienol correlated with upregulation of miR-34a in nonsmall cell lung cancer cells NSCLC;We found that Re-expression forced expression of miR-34a inhibits cell growth and induces apoptosis with concomitant down-regulation of Notch-1 signaling pathway one of the target of miR-34a; Moreover treatment of PC cells with a natural compound genistein led to the up-regulation of miR-34a resulting in the down-regulation of Notch-1 which was correlated with inhibition of cell growth and induction of apoptosis;Most importantly BR-DIM intervention in PCa patients prior to radical prostatectomy showed reexpression of miR-34a which was consistent with decreased expression of AR PSA and Notch-1 in PCa tissue specimens;MicroRNA 34a suppresses invasion through downregulation of Notch1 and Jagged1 in cervical carcinoma and choriocarcinoma cells; Computational miRNA target prediction suggested that Notch1 and Jagged1 were targets of miR-34a; By using functional assays miR-34a was demonstrated to bind to the 3' untranslated regions of Notch1 and Jagged1; Forced expression of miR-34a altered the expression of Notch1 and Jagged1 protein as well as Notch signaling as shown by the response of Hairy Enhancer of Split-1 protein to these treatments using western blot analysis;Mechanistically miR-34a sequesters Notch1 mRNA to generate a sharp threshold response where a bimodal Notch signal specifies the choice between self-renewal and differentiation;Most importantly BR-DIM intervention in PCa patients prior to radical prostatectomy showed re-expression of miR-34a which was consistent with decreased expression of AR PSA and Notch-1 in PCa tissue specimens;We also found that reexpression of miR-34a and miR-200b by transfection led to reduced expression of Notch-1 resulting in the inhibition of osteosarcoma cell proliferation invasion and angiogenesis;Rhamnetin and cirsiliol induce radiosensitization and inhibition of epithelial mesenchymal transition EMT by miR 34a mediated suppression of Notch 1 expression in non small cell lung cancer cell lines; Indeed rhamnetin and cirsiliol increased the expression of tumor-suppressive microRNA miR-34a in a p53-dependent manner leading to inhibition of Notch-1 expression;MicroRNA 34a targets notch1 and inhibits cell proliferation in glioblastoma multiforme; Also we identified notch1 as a direct target gene of miR-34a; Knockdown of notch1 showed similar cellular functions as overexpression of miR-34a both in vitro and in vivo; Collectively our findings show that miR-34a is downregulated in GBM cells and inhibits GBM growth by targeting notch1;The re-expression of miR-34 led to a marked reduction in the expression of its target gene Notch-1;Inactivation of AR and Notch 1 signaling by miR 34a attenuates prostate cancer aggressiveness; We found that over-expression of miR-34a led to reduced expression of AR PSA and Notch-1; These findings suggest that the loss of miR-34a is directly linked with up-regulation of AR and Notch-1 both of which are highly expressed in PCa and thus finding innovative approaches by which miR-34a expression could be up-regulated will have a huge impact on the treatment of PCa especially for the treatment of mCRPC	cell migration;staging;metastasis;;;drug resistance;;;;drug resistance;differentiation;drug resistance;;;;;;	breast cancer;breast cancer;breast cancer;breast cancer;breast cancer;lung squamous cell cancer;pancreatic cancer;prostate cancer;cervical and endocervical cancer;colon cancer;prostate cancer;sarcoma;lung squamous cell cancer;glioblastoma;colon cancer;prostate cancer
hsa-miR-34a-5p	NOTCH2	0.129201805242403	0.133261654068224	-0.56663957212087	4.13195343694927e-10	miRNAWalker2_validate;miRNATAP	-0.108914801108399	0.00301789969264899		NA	NA	NA
hsa-miR-34a-5p	NSD1	0.129201805242403	0.133261654068224	-0.0688993974234542	0.305261129624324	miRNATAP	-0.0811644129874296	0.00253400362520465		NA	NA	NA
hsa-miR-34a-5p	NTN1	0.129201805242403	0.133261654068224	-0.338999961041738	0.04596914368363	mirMAP	-0.195551221366116	0.00411696924024783		NA	NA	NA
hsa-miR-34a-5p	NUCKS1	0.129201805242403	0.133261654068224	0.116622350958641	0.0639431766088682	miRNAWalker2_validate	-0.0667026770482518	0.00813835564736212		NA	NA	NA
hsa-miR-34a-5p	NUP98	0.129201805242403	0.133261654068224	-0.114675340877947	0.0322689875634868	miRNAWalker2_validate	-0.0745030907736105	0.000498388543009763		NA	NA	NA
hsa-miR-34a-5p	P2RY14	0.129201805242403	0.133261654068224	-1.71578253270711	9.75110006776043e-37	MirTarget	-0.165254541692172	0.00367464794509594		NA	NA	NA
hsa-miR-34a-5p	PAX5	0.129201805242403	0.133261654068224	0.186405982880343	0.536149721725608	mirMAP	-0.366272492677797	0.00242247877534153		NA	NA	NA
hsa-miR-34a-5p	PDE4B	0.129201805242403	0.133261654068224	-0.751531967429292	1.00328243910391e-05	MirTarget	-0.141039723199721	0.0399969077756168		NA	NA	NA
hsa-miR-34a-5p	PDGFRA	0.129201805242403	0.133261654068224	-1.84169721584144	2.50038285124215e-31	miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP	-0.257308196495663	9.23678964579895e-05	22750848	Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network		glioblastoma
hsa-miR-34a-5p	PDGFRB	0.129201805242403	0.133261654068224	-0.363053423609744	0.000930448280520273	MirTarget	-0.0917607958786039	0.0375415465954454	24837198	MicroRNA 34A inhibits the growth invasion and metastasis of gastric cancer by targeting PDGFR and MET expression; In this study our aim was to identify the miRNAs that target PDGFR-α/β and to study the functions of these miRNAs miR-34a was predicted to target PDGFR and luciferase reporter assays showed that miR-34a could directly target PDGFR; Moreover the cancer-associated cell signalling pathway was studied and we found that miR-34a could inhibit Akt PKB protein kinase B phosphorylation which was restored by the overexpression of both PDGFR and MET; In conclusion miR-34a may act as a potential tumour suppressor in gastric cancer and is associated with the mechanisms of gastric cancer metastasis; miR-34a can inhibit gastric cancer tumourigenesis by targeting PDGFR and MET through the PI3K phosphoinositide 3-kinase/Akt pathway	metastasis	gastric cancer
hsa-miR-34a-5p	PDZRN3	0.129201805242403	0.133261654068224	-1.3635898424795	3.72591982347471e-27	miRNATAP	-0.175620028395096	0.00079003204867597		NA	NA	NA
hsa-miR-34a-5p	PEG10	0.129201805242403	0.133261654068224	-0.95352146824468	0.00369200350510654	miRNATAP	-0.273016344888801	0.0388193317050166		NA	NA	NA
hsa-miR-34a-5p	PFKM	0.129201805242403	0.133261654068224	-0.167575311099228	0.0685593901261937	MirTarget	-0.157438956681627	1.85297175801738e-05		NA	NA	NA
hsa-miR-34a-5p	PKIA	0.129201805242403	0.133261654068224	-1.53571066596047	4.62934386564947e-14	MirTarget;miRNATAP	-0.176305150984532	0.0338330175601233		NA	NA	NA
hsa-miR-34a-5p	PKP2	0.129201805242403	0.133261654068224	-0.390200657208209	0.00466318031568261	miRNAWalker2_validate	-0.138803551058529	0.0122639702472858		NA	NA	NA
hsa-miR-34a-5p	PLCB1	0.129201805242403	0.133261654068224	-1.66992751550185	3.40855270132597e-21	miRNATAP	-0.159895868887965	0.0280175727961689		NA	NA	NA
hsa-miR-34a-5p	PLEKHM3	0.129201805242403	0.133261654068224	-1.84131497880035	1.34528076669196e-67	MirTarget	-0.205868801316952	8.11205347490128e-06		NA	NA	NA
hsa-miR-34a-5p	PLXNA4	0.129201805242403	0.133261654068224	-3.24060572750455	3.5769955557962e-61	mirMAP	-0.189403982380291	0.0262187870956818		NA	NA	NA
hsa-miR-34a-5p	POGZ	0.129201805242403	0.133261654068224	0.221455188654849	0.000545925051104238	miRNAWalker2_validate;MirTarget;miRNATAP	-0.115996515542842	5.93563351087292e-06		NA	NA	NA
hsa-miR-34a-5p	POLR1A	0.129201805242403	0.133261654068224	0.2827350354402	8.46056429737681e-05	mirMAP	-0.0702397993944678	0.0151836967990946		NA	NA	NA
hsa-miR-34a-5p	POU6F1	0.129201805242403	0.133261654068224	-1.22160046868415	5.22496483078127e-46	MirTarget	-0.117274152775026	0.00127533239641509		NA	NA	NA
hsa-miR-34a-5p	PPARGC1B	0.129201805242403	0.133261654068224	-1.46182968985053	1.35672112520709e-22	MirTarget;miRNATAP	-0.172605157371696	0.00507730166736354		NA	NA	NA
hsa-miR-34a-5p	PPM1F	0.129201805242403	0.133261654068224	-1.01782278266201	2.82903184176664e-41	mirMAP	-0.0858407886397433	0.0071550599821468		NA	NA	NA
hsa-miR-34a-5p	PPP1R16B	0.129201805242403	0.133261654068224	-2.17774746201998	4.8680300203316e-39	MirTarget;miRNATAP	-0.359730041507559	2.54742026486253e-07		NA	NA	NA
hsa-miR-34a-5p	PRKCQ	0.129201805242403	0.133261654068224	-0.699033121447314	0.000628432051813325	MirTarget	-0.177144743171963	0.0314044607368418		NA	NA	NA
hsa-miR-34a-5p	PROX1	0.129201805242403	0.133261654068224	-3.30249132498998	3.55828560245591e-41	miRNATAP	-0.361076029941872	0.000496659248653518		NA	NA	NA
hsa-miR-34a-5p	PRR12	0.129201805242403	0.133261654068224	0.511273185427386	3.42902241254277e-12	miRNAWalker2_validate	-0.078333207325601	0.00864646430334677		NA	NA	NA
hsa-miR-34a-5p	PRR3	0.129201805242403	0.133261654068224	0.0986059727769262	0.102814473041864	miRNAWalker2_validate	-0.0543704239436873	0.0246897605249766		NA	NA	NA
hsa-miR-34a-5p	PTPN4	0.129201805242403	0.133261654068224	-0.772006027943853	1.97809004778744e-27	miRNATAP	-0.112517391591074	0.000130237676070391		NA	NA	NA
hsa-miR-34a-5p	PTPRM	0.129201805242403	0.133261654068224	-1.57471720317321	4.81055293304317e-48	miRNATAP	-0.11487754972156	0.0126724251833949		NA	NA	NA
hsa-miR-34a-5p	RAB11FIP2	0.129201805242403	0.133261654068224	-0.940510639961515	7.61132098193432e-42	MirTarget	-0.0868997913907084	0.00299937880604692		NA	NA	NA
hsa-miR-34a-5p	RASL12	0.129201805242403	0.133261654068224	-1.26839848073461	4.1008746921965e-29	MirTarget	-0.204536379062962	1.30071298228715e-05		NA	NA	NA
hsa-miR-34a-5p	RBM26	0.129201805242403	0.133261654068224	-0.221098536996249	0.000491720605422319	miRNAWalker2_validate	-0.0651209987951033	0.0105697256252346		NA	NA	NA
hsa-miR-34a-5p	RBM33	0.129201805242403	0.133261654068224	-0.372578324566227	7.98142834788434e-16	miRNAWalker2_validate	-0.0791654544757374	2.44142134996262e-05		NA	NA	NA
hsa-miR-34a-5p	RELN	0.129201805242403	0.133261654068224	-4.67087443281158	1.50848083381937e-55	miRNATAP	-0.695025679503336	4.68377105693281e-08		NA	NA	NA
hsa-miR-34a-5p	RGP1	0.129201805242403	0.133261654068224	-0.480835927395348	4.47249507470598e-06	mirMAP	-0.173237724008973	3.92258960929152e-05		NA	NA	NA
hsa-miR-34a-5p	RIMS3	0.129201805242403	0.133261654068224	-1.82635174452916	4.12617185172086e-37	MirTarget;miRNATAP	-0.193880341560836	0.00128738877180812		NA	NA	NA
hsa-miR-34a-5p	RIMS4	0.129201805242403	0.133261654068224	1.93936813754878	1.60005847788467e-09	miRNATAP	-0.271682955499854	0.0371868494799039		NA	NA	NA
hsa-miR-34a-5p	RNF41	0.129201805242403	0.133261654068224	-0.332608992732373	5.19026073026815e-12	MirTarget;miRNATAP	-0.0799795282837303	3.96197138631665e-05		NA	NA	NA
hsa-miR-34a-5p	RORA	0.129201805242403	0.133261654068224	-1.02145593857356	1.72079387585623e-26	miRNATAP	-0.0980001865353394	0.0136280279089643		NA	NA	NA
hsa-miR-34a-5p	RRAGC	0.129201805242403	0.133261654068224	-0.755786416142128	6.43029191974687e-15	MirTarget	-0.0984145741127259	0.0128376505754981		NA	NA	NA
hsa-miR-34a-5p	SATB1	0.129201805242403	0.133261654068224	-1.56127568524025	3.5724533657613e-30	MirTarget;miRNATAP	-0.154518355550859	0.00666210831392197		NA	NA	NA
hsa-miR-34a-5p	SCN1A	0.129201805242403	0.133261654068224	0.743694894902573	0.0150562525914744	miRNATAP	-0.332163469670154	0.006869962982592		NA	NA	NA
hsa-miR-34a-5p	SCN2B	0.129201805242403	0.133261654068224	-3.86249794050417	7.57828818937623e-49	MirTarget;miRNATAP	-0.317392590664706	0.00467101122494991		NA	NA	NA
hsa-miR-34a-5p	SDK2	0.129201805242403	0.133261654068224	-1.46435315270485	4.01650020293667e-10	miRNATAP	-0.253802187360148	0.00753786468900873		NA	NA	NA
hsa-miR-34a-5p	SENP1	0.129201805242403	0.133261654068224	0.16225160022366	0.00712220260415934	miRNAWalker2_validate	-0.0928112295641845	0.000118155852397336		NA	NA	NA
hsa-miR-34a-5p	SH3PXD2A	0.129201805242403	0.133261654068224	-0.038658231698439	0.664094392746129	MirTarget	-0.12357112462918	0.000519126591402531		NA	NA	NA
hsa-miR-34a-5p	SHANK3	0.129201805242403	0.133261654068224	-1.33183457706851	3.20517661766363e-41	mirMAP	-0.1851287441907	8.85443065320655e-06		NA	NA	NA
hsa-miR-34a-5p	SIK2	0.129201805242403	0.133261654068224	-2.29859523998516	3.63982740667992e-106	mirMAP	-0.142460260518517	0.00308404568404783		NA	NA	NA
hsa-miR-34a-5p	SIRT1	0.129201805242403	0.133261654068224	-0.599221126327341	9.41183428987515e-17	miRNAWalker2_validate;miRTarBase;miRNATAP	-0.123259850748874	2.68231130307605e-05	22623155;25826085;25982144;21067862;20687223;23954321;26722316;27126903;26518892;18834855	MiR 34a inhibits proliferation and migration of breast cancer through down regulation of Bcl 2 and SIRT1; In this study we aimed to determine the effect of miR-34a on the growth of breast cancer and to investigate whether its effect is achieved by targeting Bcl-2 and SIRT1; Bcl-2 and SIRT1 as the targets of miR-34a were found to be in reverse correlation with ectopic expression of miR-34a;Dysregulation of the miR 34a SIRT1 axis inhibits breast cancer stemness; Sirtuin-1 SIRT1 is a direct target of miR-34a; Here we found low levels of miR-34a and high levels of SIRT1 in CD44+/CD24- breast cancer stem cells BCSCs; MiR-34a overexpression and knockdown of SIRT1 decreased proportion of BSCSs and mammosphere formation; In nude mice xenografts stable expression of miR-34a and silencing of SIRT1 reduced tumor burden; Taken together our results demonstrated that miR-34a inhibits proliferative potential of BCSCs in vitro and in vivo at least partially by downregulating SIRT1;5 Aminolevulinic acid mediated sonodynamic therapy induces anti tumor effects in malignant melanoma via p53 miR 34a Sirt1 axis; Therefore the p53 miR-34a and SIRT1 constituted a positive feedback loop;Sirt1 which is one of the target genes for miR-34a and related to drug-resistance was strikingly up-regulated in the 5-FU-resistant cells; The ectopic expression of miR-34a in the 5-FU-resistant cells inhibited growth as in the parental cells and attenuated the resistance to 5-FU through the down-regulation of Sirt1 and E2F3; These findings suggest that miR-34a targeting the Sirt1 and E2F3 genes could negatively regulate at least in part the resistance to 5-FU in human colorectal cancer DLD-1 cells;We aimed to elucidate the molecular mechanisms underlying paclitaxel resistance of hormone-refractory prostate cancer with a special focus on the roles of miR-34a and SIRT1; MiR-34a over-expression and SIRT1 knockdown attenuated paclitaxel resistance of PC3PR cells; Thus in PC3PR cells reduced expression of miR-34a confers paclitaxel resistance via up-regulating SIRT1 and Bcl2 expression; MiR-34a and its downstream targets SIRT1 and Bcl2 play important roles in the development of paclitaxel resistance all of which can be useful biomarkers and promising therapeutic targets for the drug resistance in hormone-refractory prostate cancer;Interestingly RES increased the intracellular expression level of miR-34a which down-regulated the target gene E2F3 and its downstream Sirt1 resulting in growth inhibition;miR 34a inhibits cell proliferation in prostate cancer by downregulation of SIRT1 expression; The role of miR-34a in regulating sirtuin 1 SIRT1 in prostate cancer remains unclear; The objective of the present study was to investigate the biological function and molecular mechanisms of miR-34a regulation of SIRT1 in human prostate cancer samples and the human prostate cancer cell line PC-3; Fresh prostate tissues were obtained from patients and the miR-34a expression in prostate cancer tissues was measured using reverse transcription-quantitative polymerase chain reaction RT-qPCR qPCR and western blotting were performed to assess the effects of miR-34a overexpression on SIRT1 regulation in PC-3 cells and the cell growth was assessed by Cell Counting Kit-8 CCK-8; SIRT1 expression levels in PC-3 cells with over-expression of miR-34a were significantly reduced compared with those in the negative control P<0.05; In conclusion miR-34a inhibits the human prostate cancer cell proliferation in part through the downregulation of SIRT1 expression;In addition the present micellar system facilitated the escape of miR-34a from the endosome and release of DOX into the cell nucleus leading to the downregulation of silent information regulator 1 SIRT1 expression and inhibition of DU145 and PC3 androgen-independent prostate cancer cell proliferation;For example overexpressing miR-34a a master regulator of tumor suppression attenuates chemoresistance to 5-FU by downregulating silent information regulator 1 SIRT1 and E2F3;In PC3 cell ectopic expression of miR-34a decreased the SIRT1 mRNA and protein levels as well as protein levels of known direct target genes; Reporter assays revealed that miR-34a-induced SIRT1 inhibition occurred at the transcriptional but not post-transcriptional level despite the presence of a potential miR-34a binding site within its 3'-UTR	;;malignant trasformation;drug resistance;drug resistance;;;;drug resistance;	breast cancer;breast cancer;melanoma;colon cancer;prostate cancer;colon cancer;prostate cancer;prostate cancer;colorectal cancer;prostate cancer
hsa-miR-34a-5p	SIX5	0.129201805242403	0.133261654068224	0.439547225208798	7.34122447070223e-06	mirMAP	-0.099099766133708	0.0121514067987837		NA	NA	NA
hsa-miR-34a-5p	SLC2A13	0.129201805242403	0.133261654068224	-0.422835174294749	0.000265130322874232	miRNATAP	-0.104926381270223	0.024562295970415		NA	NA	NA
hsa-miR-34a-5p	SMAD4	0.129201805242403	0.133261654068224	-0.624967182926059	1.70248077700642e-24	miRNATAP	-0.0970813582287062	0.000114939393150447	22750848	Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network; Specifically in glioblastoma within the context of the global network promoter enrichment analysis of network edges uncovered a novel regulation of TGF-β signaling via a Smad4 transcriptomic network by miR-34a		glioblastoma
hsa-miR-34a-5p	SMAD7	0.129201805242403	0.133261654068224	-0.126914187586443	0.0344522313625721	MirTarget	-0.0801072133117801	0.00084518312196073		NA	NA	NA
hsa-miR-34a-5p	SMARCC1	0.129201805242403	0.133261654068224	0.413733510314185	6.61482380247352e-10	miRNAWalker2_validate	-0.061406546231423	0.0235976632358123		NA	NA	NA
hsa-miR-34a-5p	SMARCC2	0.129201805242403	0.133261654068224	-0.227365550061606	4.75275814043985e-07	miRNAWalker2_validate	-0.0562350435016515	0.00193028998348197		NA	NA	NA
hsa-miR-34a-5p	SNX12	0.129201805242403	0.133261654068224	-0.047164538477813	0.500056364024027	miRNAWalker2_validate;MirTarget;miRNATAP	-0.0611523371710541	0.0290225137644172		NA	NA	NA
hsa-miR-34a-5p	SON	0.129201805242403	0.133261654068224	-0.377830585566338	1.10754257781709e-08	miRNAWalker2_validate	-0.0688648232122834	0.00995385476558893		NA	NA	NA
hsa-miR-34a-5p	SOX2	0.129201805242403	0.133261654068224	1.62824878642595	1.83270623627945e-06	miRNAWalker2_validate;miRTarBase	-0.278027267640546	0.0437892548060246		NA	NA	NA
hsa-miR-34a-5p	SOX6	0.129201805242403	0.133261654068224	-2.37114135592246	4.35252660248189e-25	miRNATAP	-0.425548311852312	6.61473113909632e-06		NA	NA	NA
hsa-miR-34a-5p	SPEN	0.129201805242403	0.133261654068224	-0.644931768909036	4.95675833415509e-21	miRNATAP	-0.0943653913753376	0.000789157899561483	23642368	Mechanistically miR-34a sequesters Notch1 mRNA to generate a sharp threshold response where a bimodal Notch signal specifies the choice between self-renewal and differentiation	differentiation;drug resistance	colon cancer
hsa-miR-34a-5p	SPTBN1	0.129201805242403	0.133261654068224	-1.9362598712969	2.27075223607576e-99	miRNAWalker2_validate	-0.143349271369707	0.000559389321162466		NA	NA	NA
hsa-miR-34a-5p	SRRM2	0.129201805242403	0.133261654068224	-0.195592248193849	0.00183455327875458	miRNAWalker2_validate	-0.0907350742830141	0.000306653364912207		NA	NA	NA
hsa-miR-34a-5p	STAC2	0.129201805242403	0.133261654068224	-3.92462248766626	1.69039671507241e-20	miRNATAP	-0.393547413230739	0.0237347789462646		NA	NA	NA
hsa-miR-34a-5p	STAG2	0.129201805242403	0.133261654068224	-0.45824296739927	2.14317343940316e-11	miRNAWalker2_validate;miRNATAP	-0.0872841826229906	0.00164385503033536		NA	NA	NA
hsa-miR-34a-5p	STK38L	0.129201805242403	0.133261654068224	-0.0759878885375915	0.42193889940826	MirTarget	-0.104794927277798	0.00569858648206235		NA	NA	NA
hsa-miR-34a-5p	STX1B	0.129201805242403	0.133261654068224	-0.750600392365291	3.51549659031347e-07	mirMAP	-0.129852677602812	0.0292635061050549		NA	NA	NA
hsa-miR-34a-5p	SYNE2	0.129201805242403	0.133261654068224	-1.12890914158067	5.29295402528251e-34	miRNAWalker2_validate	-0.0810349010569187	0.0370797594308373		NA	NA	NA
hsa-miR-34a-5p	SYT1	0.129201805242403	0.133261654068224	0.523451617487376	0.0893148223385868	miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP	-0.250248705456957	0.0431763694455241		NA	NA	NA
hsa-miR-34a-5p	TAF4B	0.129201805242403	0.133261654068224	-1.04392753121047	2.11654634898376e-13	miRNATAP	-0.237310687971241	3.96133914695322e-05		NA	NA	NA
hsa-miR-34a-5p	TBC1D16	0.129201805242403	0.133261654068224	-0.318134709463815	0.000815367768719466	mirMAP	-0.108609534043346	0.0044512749374307		NA	NA	NA
hsa-miR-34a-5p	TBC1D2B	0.129201805242403	0.133261654068224	-0.710483100609729	1.38018429843516e-25	MirTarget	-0.104377897575302	0.00019523996639105		NA	NA	NA
hsa-miR-34a-5p	TBC1D5	0.129201805242403	0.133261654068224	-0.658626355606121	3.73453233008275e-23	mirMAP	-0.0642806947072653	0.0188870958375853		NA	NA	NA
hsa-miR-34a-5p	TFAM	0.129201805242403	0.133261654068224	-0.0462717520857661	0.464146827191044	miRNAWalker2_validate	-0.0763189879794692	0.00252920518202011		NA	NA	NA
hsa-miR-34a-5p	TFDP2	0.129201805242403	0.133261654068224	-0.167222078165723	0.0148084925747518	miRNATAP	-0.0549994684303003	0.0457490907968326		NA	NA	NA
hsa-miR-34a-5p	TGFBR3	0.129201805242403	0.133261654068224	-3.32389218515653	1.82193869897655e-62	miRNATAP	-0.3386975349782	8.74095048637456e-05		NA	NA	NA
hsa-miR-34a-5p	TMEM164	0.129201805242403	0.133261654068224	0.0626537796951929	0.532803987814265	MirTarget	-0.123336005213473	0.0021662274382747		NA	NA	NA
hsa-miR-34a-5p	TNPO3	0.129201805242403	0.133261654068224	0.0629214351308089	0.388780416387734	miRNAWalker2_validate	-0.0715797998671791	0.0143607233671344		NA	NA	NA
hsa-miR-34a-5p	TNRC18	0.129201805242403	0.133261654068224	0.684367562357442	1.39950330668234e-18	miRNAWalker2_validate;miRNATAP	-0.0806671182451595	0.0113634235186701		NA	NA	NA
hsa-miR-34a-5p	TOB2	0.129201805242403	0.133261654068224	-0.437716146550541	3.18938511535757e-14	MirTarget;miRNATAP	-0.0993917258769269	2.11674019944383e-05		NA	NA	NA
hsa-miR-34a-5p	TOM1L2	0.129201805242403	0.133261654068224	-0.520667499227671	1.47555060196936e-09	mirMAP	-0.0707054106158152	0.0426988971025524		NA	NA	NA
hsa-miR-34a-5p	TOPORS	0.129201805242403	0.133261654068224	-0.40306059090145	7.76010916373138e-11	miRNATAP	-0.0914548734241212	0.000260869900203719		NA	NA	NA
hsa-miR-34a-5p	TSHZ2	0.129201805242403	0.133261654068224	-3.17391923475675	1.40654093537148e-60	miRNATAP	-0.348895376632962	2.93429261061375e-05		NA	NA	NA
hsa-miR-34a-5p	TSPAN11	0.129201805242403	0.133261654068224	-1.45285413814232	3.99090114003723e-22	mirMAP	-0.194403194671151	0.00166867056228538		NA	NA	NA
hsa-miR-34a-5p	TXNIP	0.129201805242403	0.133261654068224	-2.1278383158488	8.14661112419651e-76	miRNAWalker2_validate	-0.188001155068047	0.000220784877568425		NA	NA	NA
hsa-miR-34a-5p	UBA2	0.129201805242403	0.133261654068224	-0.299523202998125	1.11013879533497e-06	miRNAWalker2_validate	-0.0636976563855548	0.0101221441740961		NA	NA	NA
hsa-miR-34a-5p	UBN2	0.129201805242403	0.133261654068224	-0.146419824539803	0.0409542397885797	miRNATAP	-0.0990576201511702	0.000548811090100129		NA	NA	NA
hsa-miR-34a-5p	UBR4	0.129201805242403	0.133261654068224	-0.3025820834257	5.09076448332762e-08	miRNAWalker2_validate	-0.0526757648239381	0.0187171185808086		NA	NA	NA
hsa-miR-34a-5p	UCP3	0.129201805242403	0.133261654068224	-0.118198378700977	0.241286299485856	MirTarget	-0.137068307707529	0.000686922122113849		NA	NA	NA
hsa-miR-34a-5p	UHRF1BP1	0.129201805242403	0.133261654068224	0.122297399830748	0.117844855889173	miRNAWalker2_validate	-0.0835480584786544	0.0076627244876198		NA	NA	NA
hsa-miR-34a-5p	UHRF2	0.129201805242403	0.133261654068224	-0.253919125572652	2.03987345194245e-05	miRNATAP	-0.0624922285682365	0.00910841226894459		NA	NA	NA
hsa-miR-34a-5p	USP24	0.129201805242403	0.133261654068224	-0.351900494500055	8.92335689953947e-08	miRNATAP	-0.0989109834824359	0.000189436998768638		NA	NA	NA
hsa-miR-34a-5p	USP47	0.129201805242403	0.133261654068224	-0.372974919273745	5.54498664879749e-11	miRNAWalker2_validate	-0.0519234282973044	0.0242722078883707		NA	NA	NA
hsa-miR-34a-5p	WTIP	0.129201805242403	0.133261654068224	-0.673697271502645	8.0399213972999e-08	mirMAP	-0.131580463765731	0.00952351345758211		NA	NA	NA
hsa-miR-34a-5p	XYLT1	0.129201805242403	0.133261654068224	-0.871966257661826	2.6739267034943e-11	MirTarget;miRNATAP	-0.162023559465777	0.00228029159172534		NA	NA	NA
hsa-miR-34a-5p	ZBTB5	0.129201805242403	0.133261654068224	0.00153115346445176	0.979144766376359	MirTarget	-0.0881910592744258	0.000160780184811576		NA	NA	NA
hsa-miR-34a-5p	ZBTB9	0.129201805242403	0.133261654068224	0.614063156672743	4.00871138381474e-27	MirTarget	-0.0709336415181799	0.00257922677425686		NA	NA	NA
hsa-miR-34a-5p	ZC3H7B	0.129201805242403	0.133261654068224	-0.332504196759922	9.99583873039342e-08	miRNATAP	-0.0604949046711599	0.016313380993163		NA	NA	NA
hsa-miR-34a-5p	ZDHHC15	0.129201805242403	0.133261654068224	-1.79355508284452	1.31588141500882e-28	MirTarget	-0.147486771938705	0.0282248408181249		NA	NA	NA
hsa-miR-34a-5p	ZDHHC17	0.129201805242403	0.133261654068224	-0.866022836216911	6.86139577858733e-36	MirTarget;miRNATAP	-0.116567034271263	5.58224812095332e-05		NA	NA	NA
hsa-miR-34a-5p	ZFHX4	0.129201805242403	0.133261654068224	-1.53229883683245	2.36314851813226e-21	MirTarget;miRNATAP	-0.169461312266869	0.0108102549259054		NA	NA	NA
hsa-miR-34a-5p	ZFR	0.129201805242403	0.133261654068224	-0.248733907402135	5.14228116414373e-05	miRNAWalker2_validate	-0.05299776693027	0.0319412942169303		NA	NA	NA
hsa-miR-34a-5p	ZHX2	0.129201805242403	0.133261654068224	-0.0211599680772165	0.765558755455652	MirTarget	-0.105606730088637	0.000194610331621197		NA	NA	NA
hsa-miR-34a-5p	ZMIZ1	0.129201805242403	0.133261654068224	0.0667656476803806	0.377382031768889	mirMAP	-0.0843161167096932	0.00535911472457257		NA	NA	NA
hsa-miR-34a-5p	ZMYM4	0.129201805242403	0.133261654068224	-0.0486238500256482	0.416035089611468	MirTarget;miRNATAP	-0.0616544458299234	0.00993260015095399		NA	NA	NA
hsa-miR-34a-5p	ZMYND11	0.129201805242403	0.133261654068224	-0.215428961944007	0.000429669677015571	MirTarget	-0.0727031352836946	0.00305730333286962		NA	NA	NA
hsa-miR-34a-5p	ZNF281	0.129201805242403	0.133261654068224	0.313231399072104	0.0298230922775962	MirTarget;miRNATAP	-0.16396767468212	0.00459987864471523		NA	NA	NA
hsa-miR-34a-5p	ZNF304	0.129201805242403	0.133261654068224	-0.231648905904749	0.00275641418971822	miRNATAP	-0.125037852533268	5.42583762688554e-05		NA	NA	NA
hsa-miR-34a-5p	ZNF324	0.129201805242403	0.133261654068224	0.136948093290457	0.0268884158673157	MirTarget	-0.0802716883262476	0.0011869240963866		NA	NA	NA
hsa-miR-34a-5p	ZNF512	0.129201805242403	0.133261654068224	-0.299390933309408	8.67551657148122e-05	miRNATAP	-0.113171020205434	0.000218714879157516		NA	NA	NA
hsa-miR-34a-5p	ZNF532	0.129201805242403	0.133261654068224	-0.486598759081946	3.90195954090326e-08	miRNATAP	-0.105069857286537	0.00330721470538643		NA	NA	NA
hsa-miR-34a-5p	ZNF551	0.129201805242403	0.133261654068224	-0.412038945252145	0.000180020113372829	MirTarget;miRNATAP	-0.206713508924214	2.72418460479193e-06		NA	NA	NA
hsa-miR-34a-5p	ZNF641	0.129201805242403	0.133261654068224	-0.634238399739506	4.03050324313056e-09	MirTarget	-0.211553540538914	1.10816403121495e-06		NA	NA	NA
hsa-miR-34a-5p	ZNF644	0.129201805242403	0.133261654068224	-0.322221007516053	1.33417062445909e-05	miRNAWalker2_validate;MirTarget;miRNATAP	-0.0745395472819498	0.0123565103084113		NA	NA	NA
hsa-miR-34a-5p	ZYG11B	0.129201805242403	0.133261654068224	-0.676145891271205	1.48820420419549e-24	MirTarget	-0.0735824420502142	0.00697488173536476		NA	NA	NA