miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-28-5p APC2 0.230152919654905 0.0742909586754846 0.382466786710938 0.250734891357193 mirMAP -0.367063763696686 0.00439410600608565 NA NA NA hsa-let-7a-3p AXIN2 1.42015538786275 7.03375209382654e-13 -1.6986287186272 5.56904404371908e-05 miRNATAP -0.580881072981708 7.52786609329052e-09 NA NA NA hsa-let-7b-3p AXIN2 0.868207752019623 1.30460056774366e-05 -1.6986287186272 5.56904404371908e-05 miRNATAP -0.466094148302635 5.47361078751581e-06 NA NA NA hsa-let-7g-3p AXIN2 3.26398061402445 3.96263126107645e-25 -1.6986287186272 5.56904404371908e-05 MirTarget -0.333037817887653 9.55083906918248e-08 NA NA NA hsa-miR-103a-3p AXIN2 1.44083190496858 1.53799939616416e-13 -1.6986287186272 5.56904404371908e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.432944543888631 2.49508578477517e-05 NA NA NA hsa-miR-107 AXIN2 1.30977326593435 1.30372468603965e-11 -1.6986287186272 5.56904404371908e-05 miRTarBase;MirTarget;PITA;miRanda;miRNATAP -0.497419239480003 1.65377519483307e-06 26191213 miR 107 promotes hepatocellular carcinoma cell proliferation by targeting Axin2; At the molecular level our results suggested that expression of Axin2 was negatively regulated by miR-107; Our observations suggested that miR-107 could promote HCC cells proliferation via targeting Axin2 and might represent a potential therapeutic target for HCC liver cancer hsa-miR-15a-5p AXIN2 2.34669284378787 1.69544424500258e-23 -1.6986287186272 5.56904404371908e-05 MirTarget;miRNATAP -0.480955940416503 4.33519973886455e-09 26252081 The combination of miR-15a and AXIN2 significantly improved the diagnostic accuracy thyroid cancer hsa-miR-15b-5p AXIN2 1.57112623124278 9.14247846750597e-13 -1.6986287186272 5.56904404371908e-05 miRTarBase;MirTarget;miRNATAP -0.560514974548682 4.5066035821598e-10 NA NA NA hsa-miR-16-2-3p AXIN2 2.31623086727196 4.29838149388188e-20 -1.6986287186272 5.56904404371908e-05 mirMAP -0.591252000994373 5.59406157801316e-15 NA NA NA hsa-miR-16-5p AXIN2 1.75824877145857 1.68592440033108e-16 -1.6986287186272 5.56904404371908e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.751187601216971 8.49686809333106e-17 NA NA NA hsa-miR-222-3p AXIN2 0.851783756239071 0.00266783568486918 -1.6986287186272 5.56904404371908e-05 miRNATAP -0.319516992304074 8.90127082603084e-06 NA NA NA hsa-miR-26b-3p AXIN2 2.18464160365372 2.11543189388328e-18 -1.6986287186272 5.56904404371908e-05 MirTarget -0.484074743403874 5.01575452903022e-10 NA NA NA hsa-miR-29a-5p AXIN2 1.46749674755271 3.34605004270294e-07 -1.6986287186272 5.56904404371908e-05 MirTarget -0.371370756814131 5.27889012104867e-07 NA NA NA hsa-miR-34a-5p AXIN2 1.9016323452565 1.43092834643601e-14 -1.6986287186272 5.56904404371908e-05 miRNAWalker2_validate;miRTarBase -0.316389522899683 8.52056660674017e-05 23624843 p53 regulates nuclear GSK 3 levels through miR 34 mediated Axin2 suppression in colorectal cancer cells; Exogenous miR-34a decreases Axin2 UTR-reporter activity through multiple binding sites within the 5' and 3' UTR of Axin2; Further RNA transcripts of miR-34 target were correlated with Axin2 in clinical data set of colorectal cancer patients colorectal cancer hsa-miR-590-3p AXIN2 2.59289455139753 1.03200520972022e-21 -1.6986287186272 5.56904404371908e-05 MirTarget;PITA;miRanda;miRNATAP -0.47289600145345 8.55966813825129e-11 NA NA NA hsa-miR-10a-5p CAMK2A 1.15016989191194 0.00372037233992369 -4.13920739991396 5.06813084231462e-14 mirMAP -0.692687780924421 1.2592932316587e-26 NA NA NA hsa-miR-10b-5p CAMK2A -0.155951595811628 0.555006386998027 -4.13920739991396 5.06813084231462e-14 mirMAP -0.806460602294085 1.54003382280288e-15 NA NA NA hsa-miR-1226-3p CAMK2A 1.38118928579963 0.000205503474787488 -4.13920739991396 5.06813084231462e-14 mirMAP -0.68294692904813 3.02529982478943e-17 NA NA NA hsa-miR-125a-5p CAMK2A 0.599529391575274 0.0102300147180307 -4.13920739991396 5.06813084231462e-14 mirMAP -0.749271996568678 9.6185113835477e-11 NA NA NA hsa-miR-130b-5p CAMK2A 2.9963110846538 1.98883029416455e-18 -4.13920739991396 5.06813084231462e-14 mirMAP -0.788484881242789 3.07944990682846e-26 NA NA NA hsa-miR-144-3p CAMK2A 0.658119849508907 0.146943823997989 -4.13920739991396 5.06813084231462e-14 mirMAP -0.345479318710768 1.98227677341234e-08 NA NA NA hsa-miR-148a-3p CAMK2A 1.26728238710376 2.52325607402829e-06 -4.13920739991396 5.06813084231462e-14 miRNATAP -0.448587772260439 7.9925096590489e-06 NA NA NA hsa-miR-148b-5p CAMK2A 2.18024067300781 2.84770452413262e-14 -4.13920739991396 5.06813084231462e-14 mirMAP -1.00860522005724 7.60685952274604e-28 NA NA NA hsa-miR-15b-3p CAMK2A 2.33847028227712 4.29662877950836e-19 -4.13920739991396 5.06813084231462e-14 mirMAP -1.06651894046244 6.28391750734951e-30 NA NA NA hsa-miR-185-5p CAMK2A 2.34016206907488 1.17481626642022e-26 -4.13920739991396 5.06813084231462e-14 mirMAP -1.20773092934503 1.60357939629387e-27 NA NA NA hsa-miR-19b-1-5p CAMK2A 2.57951428759379 4.31576118703427e-20 -4.13920739991396 5.06813084231462e-14 mirMAP -0.864150001209523 4.05477298222864e-21 NA NA NA hsa-miR-205-5p CAMK2A 4.1389800495524 2.05488295686453e-12 -4.13920739991396 5.06813084231462e-14 mirMAP -0.371435532574286 1.57583131673214e-17 NA NA NA hsa-miR-25-3p CAMK2A 1.36472605225697 4.83790725935681e-11 -4.13920739991396 5.06813084231462e-14 MirTarget -1.13176632561112 1.24363891592022e-19 NA NA NA hsa-miR-26b-5p CAMK2A 0.885393662798425 3.2116297961629e-06 -4.13920739991396 5.06813084231462e-14 miRNATAP -1.08357243866377 1.08353083251473e-14 NA NA NA hsa-miR-30b-5p CAMK2A 0.800822374912712 0.000133601914525413 -4.13920739991396 5.06813084231462e-14 mirMAP -0.909292779774021 1.20826401788873e-12 NA NA NA hsa-miR-30c-5p CAMK2A 0.778774633108 0.000285599212429136 -4.13920739991396 5.06813084231462e-14 mirMAP -1.03323008829076 6.45287014953708e-17 NA NA NA hsa-miR-30d-5p CAMK2A 0.675423997639582 0.00270618816039773 -4.13920739991396 5.06813084231462e-14 mirMAP -1.36250068562711 1.91289582682655e-33 NA NA NA hsa-miR-30e-5p CAMK2A 1.23904909539663 1.35561917122157e-09 -4.13920739991396 5.06813084231462e-14 mirMAP -1.65598193147241 1.61549017877907e-43 NA NA NA hsa-miR-32-5p CAMK2A 2.34056473219422 6.24134585974322e-20 -4.13920739991396 5.06813084231462e-14 MirTarget -0.856582041487233 4.3042446859323e-18 NA NA NA hsa-miR-331-3p CAMK2A 2.28379581858927 1.99663919173155e-18 -4.13920739991396 5.06813084231462e-14 MirTarget -1.15767161088161 1.62908691123866e-35 NA NA NA hsa-miR-335-5p CAMK2A 1.77247705492746 2.22457658872091e-06 -4.13920739991396 5.06813084231462e-14 mirMAP -0.454419135520998 1.59521837908844e-10 NA NA NA hsa-miR-34a-3p CAMK2A 1.75590866103657 8.02801510630657e-09 -4.13920739991396 5.06813084231462e-14 mirMAP -0.705996788293823 2.02378001337888e-13 NA NA NA hsa-miR-361-3p CAMK2A 1.07367425434318 1.73142774168958e-09 -4.13920739991396 5.06813084231462e-14 mirMAP -0.897217277579828 2.58013522403889e-09 NA NA NA hsa-miR-3614-5p CAMK2A 2.17736331059655 2.19144831318484e-08 -4.13920739991396 5.06813084231462e-14 mirMAP -0.398662975251304 1.85411627951307e-08 NA NA NA hsa-miR-363-3p CAMK2A 1.50575300026701 0.00020976164678918 -4.13920739991396 5.06813084231462e-14 MirTarget -0.473373515026262 4.74898873232694e-13 NA NA NA hsa-miR-3913-5p CAMK2A 2.44353493655328 8.95279496632448e-15 -4.13920739991396 5.06813084231462e-14 mirMAP -0.788064985623782 1.83131242466922e-21 NA NA NA hsa-miR-429 CAMK2A 4.48815175680773 2.44117492218206e-17 -4.13920739991396 5.06813084231462e-14 miRNATAP -0.619342685313725 1.37901796029065e-43 NA NA NA hsa-miR-582-3p CAMK2A 0.00876844181512659 0.977126166214707 -4.13920739991396 5.06813084231462e-14 mirMAP -0.516161329153302 5.97345257548268e-09 NA NA NA hsa-miR-625-5p CAMK2A 1.42540152147292 1.95797147911206e-06 -4.13920739991396 5.06813084231462e-14 mirMAP -0.484399409318363 9.45286382700684e-07 NA NA NA hsa-miR-7-1-3p CAMK2A 1.84950311431067 1.25300363397654e-13 -4.13920739991396 5.06813084231462e-14 MirTarget -0.814069609431641 4.7841559250915e-15 NA NA NA hsa-miR-92a-3p CAMK2A 2.06460102658973 1.44784291084757e-19 -4.13920739991396 5.06813084231462e-14 MirTarget -1.24024247040884 1.02242820632254e-30 NA NA NA hsa-miR-29c-3p CAMK2B -0.00968972577705429 0.97099586346872 0.669901839915794 0.194250472530958 mirMAP -0.311266024048565 0.000929417287362308 NA NA NA hsa-miR-186-5p CCND1 1.47445398888668 3.0781726595413e-15 0.0828319966762319 0.840332435689448 mirMAP -0.319993507741074 0.0020448551843367 NA NA NA hsa-miR-193a-3p CCND1 1.60460546928078 2.86169793322984e-07 0.0828319966762319 0.840332435689448 MirTarget;PITA;miRanda -0.351734964348069 1.30056584701733e-08 NA NA NA hsa-miR-340-5p CCND1 0.30282999308409 0.157744789519131 0.0828319966762319 0.840332435689448 mirMAP -0.529085780655826 9.29072904979919e-09 NA NA NA hsa-miR-374b-5p CCND1 0.0654362503857184 0.722673188879465 0.0828319966762319 0.840332435689448 miRNAWalker2_validate;MirTarget -0.416222074203323 0.000132219455740898 NA NA NA hsa-miR-497-5p CCND1 0.0257087130056286 0.918145413833358 0.0828319966762319 0.840332435689448 MirTarget;miRNATAP -0.30773442281542 0.000110601843767413 21350001 Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer breast cancer hsa-let-7a-3p CCND2 1.42015538786275 7.03375209382654e-13 -2.42747067684236 2.06814828958882e-10 mirMAP -0.440555668621489 2.14967330798537e-06 20418948 MicroRNA let 7a inhibits proliferation of human prostate cancer cells in vitro and in vivo by targeting E2F2 and CCND2 prostate cancer hsa-let-7a-5p CCND2 0.618599506841644 2.76973453058748e-05 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.503238938401113 9.92586197811674e-05 20418948 MicroRNA let 7a inhibits proliferation of human prostate cancer cells in vitro and in vivo by targeting E2F2 and CCND2 prostate cancer hsa-let-7b-5p CCND2 0.604314269683977 0.00140009936153214 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.372644945722985 0.000202758514128247 NA NA NA hsa-let-7f-1-3p CCND2 1.55054488387679 7.31326775537952e-11 -2.42747067684236 2.06814828958882e-10 mirMAP -0.349075249109793 1.19776506071246e-05 NA NA NA hsa-let-7f-5p CCND2 0.495648727272215 0.00355972741198794 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.395067035409999 0.000431247614557398 NA NA NA hsa-let-7g-5p CCND2 1.20061455355116 1.50237505511483e-12 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.78482657734201 2.2934101130382e-13 NA NA NA hsa-miR-106a-5p CCND2 2.48882002962836 1.99757727374521e-12 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.460265785003224 1.90572227650597e-20 NA NA NA hsa-miR-106b-5p CCND2 2.46782146831112 1.36171495805632e-23 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.723802321113981 4.62852843641777e-26 NA NA NA hsa-miR-130b-5p CCND2 2.9963110846538 1.98883029416455e-18 -2.42747067684236 2.06814828958882e-10 mirMAP -0.524276006004661 2.15252650149472e-24 NA NA NA hsa-miR-141-3p CCND2 5.02396127982626 2.19224509139725e-24 -2.42747067684236 2.06814828958882e-10 MirTarget;TargetScan -0.336824974322951 8.46453268716016e-23 NA NA NA hsa-miR-151a-3p CCND2 1.24018761527407 1.08839919675408e-07 -2.42747067684236 2.06814828958882e-10 mirMAP -0.618872158164273 1.57062556462901e-15 NA NA NA hsa-miR-15a-5p CCND2 2.34669284378787 1.69544424500258e-23 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.558385276567589 5.78612617845985e-14 NA NA NA hsa-miR-15b-5p CCND2 1.57112623124278 9.14247846750597e-13 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.814047353716774 1.36644748676197e-24 NA NA NA hsa-miR-16-2-3p CCND2 2.31623086727196 4.29838149388188e-20 -2.42747067684236 2.06814828958882e-10 mirMAP -0.524415153934827 5.42085565840902e-14 NA NA NA hsa-miR-16-5p CCND2 1.75824877145857 1.68592440033108e-16 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;miRNATAP -0.624880555696101 7.5948593080299e-14 NA NA NA hsa-miR-17-5p CCND2 3.2710598467455 9.93128340539455e-27 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.576586035201243 5.39762569803648e-26 NA NA NA hsa-miR-181a-2-3p CCND2 2.19062681262366 3.81790102612782e-13 -2.42747067684236 2.06814828958882e-10 mirMAP -0.371385706331271 5.48097191184985e-10 NA NA NA hsa-miR-182-5p CCND2 3.53923166221814 5.07781258121574e-21 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.418107303561313 5.83833309647385e-20 NA NA NA hsa-miR-183-5p CCND2 4.19757025992371 4.79612296318304e-26 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.406097602561121 1.1832385157764e-21 NA NA NA hsa-miR-185-5p CCND2 2.34016206907488 1.17481626642022e-26 -2.42747067684236 2.06814828958882e-10 MirTarget;miRNATAP -0.596214855521239 5.09732672184216e-14 NA NA NA hsa-miR-186-5p CCND2 1.47445398888668 3.0781726595413e-15 -2.42747067684236 2.06814828958882e-10 mirMAP;miRNATAP -0.753228825405404 3.55444659312987e-15 NA NA NA hsa-miR-188-5p CCND2 2.52825126596644 6.78099435999778e-14 -2.42747067684236 2.06814828958882e-10 PITA;mirMAP -0.327199573697285 9.78244941189197e-09 NA NA NA hsa-miR-191-5p CCND2 2.30038190670664 9.93191704545938e-17 -2.42747067684236 2.06814828958882e-10 MirTarget -0.63056469865633 4.58280529094783e-24 NA NA NA hsa-miR-19a-3p CCND2 3.42309334186656 3.02671914353412e-28 -2.42747067684236 2.06814828958882e-10 MirTarget;miRNATAP -0.478555105133488 2.03415225430867e-18 NA NA NA hsa-miR-19b-3p CCND2 2.49529833021187 1.57028265846699e-23 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;MirTarget;miRNATAP -0.644240893236217 5.93065810659583e-21 NA NA NA hsa-miR-200a-3p CCND2 4.59434485520731 6.38952518573476e-18 -2.42747067684236 2.06814828958882e-10 MirTarget -0.322639326506763 1.12744821991113e-23 NA NA NA hsa-miR-20a-5p CCND2 3.15577933619191 4.19753346442454e-25 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.552675029838617 1.98133209896024e-23 NA NA NA hsa-miR-26b-5p CCND2 0.885393662798425 3.2116297961629e-06 -2.42747067684236 2.06814828958882e-10 mirMAP;miRNATAP -0.333191234288059 0.000785967313666436 NA NA NA hsa-miR-301a-3p CCND2 2.81024345929638 2.29784847962242e-17 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate -0.490714440601798 1.13987935585442e-18 NA NA NA hsa-miR-30d-3p CCND2 0.977747550180601 4.3048212205381e-05 -2.42747067684236 2.06814828958882e-10 mirMAP -0.514799428246913 2.69094766335815e-11 NA NA NA hsa-miR-30e-3p CCND2 -0.215663037684509 0.235375122783546 -2.42747067684236 2.06814828958882e-10 mirMAP -0.317748716556734 0.00256884077064715 NA NA NA hsa-miR-32-3p CCND2 2.02436999565685 5.94091197945307e-09 -2.42747067684236 2.06814828958882e-10 mirMAP -0.37065809204682 5.74913234109809e-10 NA NA NA hsa-miR-320a CCND2 0.438165828017084 0.0390159073347133 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;mirMAP;miRNATAP -0.366959333753783 3.90012764364419e-05 NA NA NA hsa-miR-320b CCND2 1.55692969039548 1.41071034251915e-08 -2.42747067684236 2.06814828958882e-10 mirMAP;miRNATAP -0.389495451202309 5.62361965191887e-09 NA NA NA hsa-miR-324-3p CCND2 2.08739139768981 3.11885987067952e-13 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate -0.569926030100518 1.57078270718816e-20 NA NA NA hsa-miR-331-5p CCND2 2.17414714166315 1.54547681391888e-18 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.55418360999634 4.24751797285043e-14 NA NA NA hsa-miR-33a-3p CCND2 1.72765312072219 1.51784443453521e-07 -2.42747067684236 2.06814828958882e-10 MirTarget -0.474892003832155 3.60158523540778e-15 NA NA NA hsa-miR-374b-3p CCND2 0.930487774873495 2.74420094310516e-05 -2.42747067684236 2.06814828958882e-10 mirMAP -0.379294826109076 7.61411367904561e-06 NA NA NA hsa-miR-423-5p CCND2 0.963563145758616 9.86109015204915e-07 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate -0.681308347713645 2.78087673863117e-13 NA NA NA hsa-miR-429 CCND2 4.48815175680773 2.44117492218206e-17 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.316889169500172 1.77696184266368e-22 NA NA NA hsa-miR-503-5p CCND2 3.66513190181895 6.60300917645278e-21 -2.42747067684236 2.06814828958882e-10 MirTarget -0.31264390956225 5.2815091282227e-11 25860935 We then identified two targets of miR-503 CCND2 and CCND3 breast cancer hsa-miR-550a-5p CCND2 2.11025227932763 6.94489556637146e-12 -2.42747067684236 2.06814828958882e-10 MirTarget -0.44540662591501 2.41152035101861e-14 NA NA NA hsa-miR-589-3p CCND2 2.51971841868825 2.39125940264107e-11 -2.42747067684236 2.06814828958882e-10 mirMAP -0.360588568041429 3.76015378643146e-11 NA NA NA hsa-miR-590-3p CCND2 2.59289455139753 1.03200520972022e-21 -2.42747067684236 2.06814828958882e-10 miRanda;mirMAP -0.419988530136573 3.79848108645639e-10 NA NA NA hsa-miR-590-5p CCND2 3.18300989862077 2.06813568597893e-26 -2.42747067684236 2.06814828958882e-10 mirMAP -0.50562344923364 6.73026539304424e-18 NA NA NA hsa-miR-660-5p CCND2 1.82692095272076 1.92040083607196e-13 -2.42747067684236 2.06814828958882e-10 mirMAP -0.361636929774302 8.5078492819456e-07 NA NA NA hsa-miR-7-1-3p CCND2 1.84950311431067 1.25300363397654e-13 -2.42747067684236 2.06814828958882e-10 mirMAP -0.518854235917429 5.32697612805784e-13 NA NA NA hsa-miR-877-5p CCND2 2.94916202082736 1.8151927276044e-13 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate -0.361363420346396 6.83899428438154e-13 NA NA NA hsa-miR-93-5p CCND2 3.03961860136032 1.11672209617395e-24 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.640135233296746 3.73391346199191e-30 NA NA NA hsa-miR-96-5p CCND2 4.89433085814374 1.92000659886961e-31 -2.42747067684236 2.06814828958882e-10 TargetScan;miRNATAP -0.382951897231727 7.25785958201884e-21 NA NA NA hsa-miR-125a-5p DAAM1 0.599529391575274 0.0102300147180307 -0.942213696830475 0.00027775597362759 MirTarget -0.362868736041077 7.62638741423532e-12 NA NA NA hsa-miR-140-5p DAAM1 0.844753502512594 3.73722278438606e-05 -0.942213696830475 0.00027775597362759 miRanda -0.304699334450491 5.89677534024278e-07 NA NA NA hsa-miR-181a-5p DAAM1 2.29556023480783 1.8138457900616e-21 -0.942213696830475 0.00027775597362759 mirMAP -0.322824758326189 4.08278167042441e-11 NA NA NA hsa-miR-186-5p DAAM1 1.47445398888668 3.0781726595413e-15 -0.942213696830475 0.00027775597362759 MirTarget;mirMAP -0.368925277090905 1.38277768429258e-08 NA NA NA hsa-miR-29b-3p DAAM1 1.65828197923813 1.02676780888141e-09 -0.942213696830475 0.00027775597362759 MirTarget;miRNATAP -0.345351912509756 6.04658193265482e-15 NA NA NA hsa-miR-34a-5p DAAM1 1.9016323452565 1.43092834643601e-14 -0.942213696830475 0.00027775597362759 MirTarget;miRNATAP -0.314744989230111 9.66343935466443e-11 NA NA NA hsa-miR-141-5p DAAM2 3.81419396518882 3.21977359736126e-18 -2.22700754971104 2.14986647076169e-10 mirMAP -0.380875705787807 1.11753905137362e-26 NA NA NA hsa-miR-182-5p DAAM2 3.53923166221814 5.07781258121574e-21 -2.22700754971104 2.14986647076169e-10 mirMAP -0.375542841324343 4.32635099356557e-19 NA NA NA hsa-miR-18a-5p DAAM2 3.78535678765353 3.72446596213886e-26 -2.22700754971104 2.14986647076169e-10 miRNAWalker2_validate -0.334705695374522 1.00225123053855e-12 NA NA NA hsa-miR-1976 DAAM2 2.06550563678192 7.81396978619772e-18 -2.22700754971104 2.14986647076169e-10 mirMAP -0.635241050457801 1.06336591472668e-21 NA NA NA hsa-miR-19b-3p DAAM2 2.49529833021187 1.57028265846699e-23 -2.22700754971104 2.14986647076169e-10 miRNAWalker2_validate -0.603285529228415 7.99036004572353e-22 NA NA NA hsa-miR-205-5p DAAM2 4.1389800495524 2.05488295686453e-12 -2.22700754971104 2.14986647076169e-10 mirMAP -0.31809708429492 2.29594126518672e-33 NA NA NA hsa-miR-339-5p DAAM2 2.68710938429893 3.03134080808154e-16 -2.22700754971104 2.14986647076169e-10 miRanda -0.347838572362897 2.46899789836209e-12 NA NA NA hsa-miR-361-3p DAAM2 1.07367425434318 1.73142774168958e-09 -2.22700754971104 2.14986647076169e-10 mirMAP -0.606835022253672 1.57886551868404e-10 NA NA NA hsa-miR-590-3p DAAM2 2.59289455139753 1.03200520972022e-21 -2.22700754971104 2.14986647076169e-10 miRanda;mirMAP -0.543327785529025 1.51598725119254e-19 NA NA NA hsa-miR-33a-3p DKK2 1.72765312072219 1.51784443453521e-07 1.44564448604015 0.00747875982641354 mirMAP -0.333670025356465 0.0001069453896843 NA NA NA hsa-miR-361-5p DKK2 0.971859117235239 5.30236555707088e-09 1.44564448604015 0.00747875982641354 miRanda -0.529805018231185 0.000736067537533342 NA NA NA hsa-miR-486-5p DKK2 -0.194913133034028 0.607377798807705 1.44564448604015 0.00747875982641354 miRanda;miRNATAP -0.316330846053953 4.09529683167035e-06 NA NA NA hsa-miR-664a-3p DKK2 0.634721925861133 0.00520070178640421 1.44564448604015 0.00747875982641354 mirMAP -0.454400313588311 8.24508477503484e-05 NA NA NA hsa-miR-92b-3p FZD10 1.20409245530001 3.41055816361655e-06 -1.28150312911457 0.0222651851945126 miRNATAP -0.321084810294164 0.00202154343824695 NA NA NA hsa-let-7i-5p FZD3 0.412877696970403 0.00622731051981756 -0.309421802986829 0.225620520315636 MirTarget;miRNATAP -0.399590260605759 1.3000716715047e-06 NA NA NA hsa-miR-24-3p FZD4 0.99989036772428 1.35595013650376e-07 -0.82842258037894 0.00067769989049317 miRNAWalker2_validate -0.359185041809163 4.66677691729471e-09 NA NA NA hsa-miR-106b-5p FZD7 2.46782146831112 1.36171495805632e-23 -2.07792245991139 2.14296526511864e-14 miRNATAP -0.339574506280624 3.43686586684063e-11 NA NA NA hsa-miR-186-5p FZD7 1.47445398888668 3.0781726595413e-15 -2.07792245991139 2.14296526511864e-14 mirMAP -0.421660397889243 1.57443547405505e-09 NA NA NA hsa-miR-590-3p FZD7 2.59289455139753 1.03200520972022e-21 -2.07792245991139 2.14296526511864e-14 miRanda -0.352411608450585 1.67919803776145e-13 NA NA NA hsa-miR-101-3p JUN 0.522819989585461 0.00375627731618038 -2.04611084807692 9.1524625995215e-13 miRNAWalker2_validate -0.362533052186516 4.72957409908478e-06 NA NA NA hsa-miR-15a-5p JUN 2.34669284378787 1.69544424500258e-23 -2.04611084807692 9.1524625995215e-13 miRNAWalker2_validate -0.322829003344663 1.37042285263916e-08 NA NA NA hsa-miR-16-5p JUN 1.75824877145857 1.68592440033108e-16 -2.04611084807692 9.1524625995215e-13 miRNAWalker2_validate -0.384340701644607 1.66878593693069e-09 NA NA NA hsa-miR-32-5p JUN 2.34056473219422 6.24134585974322e-20 -2.04611084807692 9.1524625995215e-13 miRNATAP -0.413566434466745 1.10620082409085e-15 NA NA NA hsa-miR-590-3p JUN 2.59289455139753 1.03200520972022e-21 -2.04611084807692 9.1524625995215e-13 miRanda -0.362021445664138 5.65305416742662e-13 NA NA NA hsa-miR-92a-3p JUN 2.06460102658973 1.44784291084757e-19 -2.04611084807692 9.1524625995215e-13 miRNATAP -0.395074792110845 1.74644010636679e-11 NA NA NA hsa-miR-93-5p JUN 3.03961860136032 1.11672209617395e-24 -2.04611084807692 9.1524625995215e-13 miRNAWalker2_validate -0.361575830576226 1.64388759918119e-16 NA NA NA hsa-miR-130a-3p MAPK10 2.02021855058359 1.26427102520415e-11 -1.39613685607096 0.000971935890100464 miRNATAP -0.425271273370886 1.25010595009869e-10 NA NA NA hsa-miR-146b-5p MAPK10 1.75587235896724 1.15724631266659e-07 -1.39613685607096 0.000971935890100464 miRanda -0.590131350156063 2.34286000506143e-24 NA NA NA hsa-miR-193a-3p MAPK10 1.60460546928078 2.86169793322984e-07 -1.39613685607096 0.000971935890100464 miRanda;miRNATAP -0.42329172270216 2.92418176925891e-11 NA NA NA hsa-miR-221-3p MAPK10 0.451556679024397 0.0909808299917811 -1.39613685607096 0.000971935890100464 miRNATAP -0.397173855876525 2.05290544452981e-07 NA NA NA hsa-miR-222-3p MAPK10 0.851783756239071 0.00266783568486918 -1.39613685607096 0.000971935890100464 miRNATAP -0.438283382047286 7.66762618038364e-10 NA NA NA hsa-miR-29a-3p MAPK10 -0.35074463683376 0.161238718982428 -1.39613685607096 0.000971935890100464 miRNATAP -0.454036231063091 2.56598108627441e-08 NA NA NA hsa-miR-455-5p MAPK10 2.2582442061694 1.43472128037398e-13 -1.39613685607096 0.000971935890100464 miRanda -0.32061697262034 7.65297587236286e-07 NA NA NA hsa-miR-590-3p MAPK10 2.59289455139753 1.03200520972022e-21 -1.39613685607096 0.000971935890100464 miRanda;mirMAP -0.317298220210079 1.7873353325919e-05 NA NA NA hsa-let-7f-5p MYC 0.495648727272215 0.00355972741198794 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.302610362502413 0.00593577090066522 NA NA NA hsa-let-7g-5p MYC 1.20061455355116 1.50237505511483e-12 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate;miRTarBase -0.647634835001101 8.67569135821405e-10 NA NA NA hsa-miR-34a-5p MYC 1.9016323452565 1.43092834643601e-14 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate;miRTarBase -0.359767953473847 5.62932761832786e-07 25572695;25686834;21460242;22159222;23640973;22830357;22235332 The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;miR 34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c Myc pathway;Myc mediated repression of microRNA 34a promotes high grade transformation of B cell lymphoma by dysregulation of FoxP1;MicroRNA 34a suppresses malignant transformation by targeting c Myc transcriptional complexes in human renal cell carcinoma; We investigated the functional effects of microRNA-34a miR-34a on c-Myc transcriptional complexes in renal cell carcinoma; miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region which was revealed by luciferase reporter assays; Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription indicating a novel role of miR-34a in the regulation of transcription by c-Myc;Among them miR-34a was also associated with poor prognosis in 2 independent series of leukemic and nodal MCL and in cooperation with high expression of the MYC oncogene;We report that miR-34a did not inhibit cell proliferation notwithstanding a marked down-regulation of c-MYC;MicroRNA 34a modulates c Myc transcriptional complexes to suppress malignancy in human prostate cancer cells; We studied the functional effects of miR-34a on c-Myc transcriptional complexes in PC-3 prostate cancer cells; miR-34a downregulated expression of c-Myc oncogene by targeting its 3' UTR as shown by luciferase reporter assays; This is the first report to document that miR-34a suppresses assembly and function of the c-Myc-Skp2-Miz1 complex that activates RhoA and the c-Myc-pTEFB complex that elongates transcription of various genes suggesting a novel role of miR-34a in the regulation of transcription by c-Myc complex ;;;malignant trasformation;worse prognosis;; bladder cancer;liver cancer;B cell lymphoma;kidney renal cell cancer;lymphoma;lymphoma;prostate cancer hsa-miR-423-5p MYC 0.963563145758616 9.86109015204915e-07 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.592117097378242 1.10389937335588e-10 NA NA NA hsa-miR-98-5p MYC 1.11154309866014 1.24143909012085e-08 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate;miRTarBase -0.602921793997467 5.7325871539819e-11 NA NA NA hsa-miR-940 NFATC1 3.21011374578759 2.7923171128495e-14 -1.85038550878621 5.2595171540405e-08 PITA -0.324901980633973 1.03105739407377e-15 NA NA NA hsa-miR-16-2-3p NFATC2 2.31623086727196 4.29838149388188e-20 -2.09940213646525 2.77134949511158e-05 mirMAP -0.346662368458709 0.000179256594294205 NA NA NA hsa-miR-185-5p NFATC2 2.34016206907488 1.17481626642022e-26 -2.09940213646525 2.77134949511158e-05 MirTarget -0.377810783509097 0.000327278994012812 NA NA NA hsa-miR-186-5p NFATC2 1.47445398888668 3.0781726595413e-15 -2.09940213646525 2.77134949511158e-05 mirMAP -0.437555927141547 0.000604504699648039 NA NA NA hsa-miR-19a-3p NFATC2 3.42309334186656 3.02671914353412e-28 -2.09940213646525 2.77134949511158e-05 mirMAP -0.373437340706404 2.96351119749213e-07 NA NA NA hsa-miR-19b-3p NFATC2 2.49529833021187 1.57028265846699e-23 -2.09940213646525 2.77134949511158e-05 mirMAP -0.469765074696736 3.34509012953115e-07 NA NA NA hsa-miR-26b-3p NFATC2 2.18464160365372 2.11543189388328e-18 -2.09940213646525 2.77134949511158e-05 MirTarget -0.44806551147109 1.62954234122775e-06 NA NA NA hsa-miR-27b-5p NFATC2 0.393316367667332 0.051702301924024 -2.09940213646525 2.77134949511158e-05 mirMAP -0.365339117485442 0.00275776764973734 NA NA NA hsa-miR-30c-5p NFATC2 0.778774633108 0.000285599212429136 -2.09940213646525 2.77134949511158e-05 MirTarget;mirMAP -0.368293366563006 0.00123567961865253 NA NA NA hsa-miR-30e-5p NFATC2 1.23904909539663 1.35561917122157e-09 -2.09940213646525 2.77134949511158e-05 MirTarget -0.336147434109482 0.00451047767094652 NA NA NA hsa-miR-320a NFATC2 0.438165828017084 0.0390159073347133 -2.09940213646525 2.77134949511158e-05 MirTarget -0.350663524320559 0.00250598418881894 NA NA NA hsa-miR-34a-3p NFATC2 1.75590866103657 8.02801510630657e-09 -2.09940213646525 2.77134949511158e-05 mirMAP -0.301138281046132 0.000597201447878319 NA NA NA hsa-miR-3607-3p NFATC2 2.68532138541128 5.66716351955047e-14 -2.09940213646525 2.77134949511158e-05 MirTarget;mirMAP -0.321712713536906 1.93008019978856e-06 NA NA NA hsa-miR-3613-5p NFATC2 2.64358387329263 1.0373753017245e-24 -2.09940213646525 2.77134949511158e-05 mirMAP -0.582140424179043 1.2743589534383e-10 NA NA NA hsa-miR-484 NFATC2 1.81844463411787 1.82951571230938e-15 -2.09940213646525 2.77134949511158e-05 MirTarget -0.38479959768158 0.000202349753737943 NA NA NA hsa-miR-590-3p NFATC2 2.59289455139753 1.03200520972022e-21 -2.09940213646525 2.77134949511158e-05 mirMAP -0.321676608175333 0.000262933617887873 NA NA NA hsa-miR-15b-3p NFATC4 2.33847028227712 4.29662877950836e-19 -1.80092988307702 3.48834735342005e-10 mirMAP -0.42678455481147 1.50897022571625e-17 NA NA NA hsa-miR-2355-5p NFATC4 1.32510310704724 8.25139516692683e-07 -1.80092988307702 3.48834735342005e-10 MirTarget -0.365394782747818 7.50941976584262e-13 NA NA NA hsa-miR-361-3p NFATC4 1.07367425434318 1.73142774168958e-09 -1.80092988307702 3.48834735342005e-10 mirMAP -0.397492986056446 3.76815247508252e-07 NA NA NA hsa-miR-484 NFATC4 1.81844463411787 1.82951571230938e-15 -1.80092988307702 3.48834735342005e-10 MirTarget;miRNATAP -0.319008427014768 8.35906924043843e-08 NA NA NA hsa-miR-629-3p NFATC4 2.36570947321815 1.33458201201618e-11 -1.80092988307702 3.48834735342005e-10 mirMAP -0.317779815801302 3.14548353729131e-13 NA NA NA hsa-let-7a-5p NKD1 0.618599506841644 2.76973453058748e-05 -1.69553775455222 4.2654677240011e-05 TargetScan -0.412393121442761 0.00297883843016037 NA NA NA hsa-miR-140-5p NKD1 0.844753502512594 3.73722278438606e-05 -1.69553775455222 4.2654677240011e-05 miRanda -0.379888847864967 0.000112585187849131 NA NA NA hsa-miR-361-5p NKD1 0.971859117235239 5.30236555707088e-09 -1.69553775455222 4.2654677240011e-05 miRanda -0.661066416940325 3.2521696823557e-08 NA NA NA hsa-miR-532-5p NKD1 1.55697650978597 1.57884735535196e-11 -1.69553775455222 4.2654677240011e-05 PITA;miRNATAP -0.414476725623264 1.11427017775432e-06 NA NA NA hsa-let-7a-3p PLCB4 1.42015538786275 7.03375209382654e-13 -3.76947582666435 4.09541818232216e-14 mirMAP;miRNATAP -0.83254422778899 5.59274705865604e-12 NA NA NA hsa-let-7a-5p PLCB4 0.618599506841644 2.76973453058748e-05 -3.76947582666435 4.09541818232216e-14 miRNATAP -0.487033219905897 0.00445261480865196 NA NA NA hsa-let-7b-3p PLCB4 0.868207752019623 1.30460056774366e-05 -3.76947582666435 4.09541818232216e-14 mirMAP;miRNATAP -0.707112138165477 1.00040779115694e-08 NA NA NA hsa-let-7b-5p PLCB4 0.604314269683977 0.00140009936153214 -3.76947582666435 4.09541818232216e-14 miRNATAP -0.455031465278346 0.000590887935416328 NA NA NA hsa-let-7f-1-3p PLCB4 1.55054488387679 7.31326775537952e-11 -3.76947582666435 4.09541818232216e-14 mirMAP -0.709444351435182 7.04182417212984e-12 NA NA NA hsa-let-7g-5p PLCB4 1.20061455355116 1.50237505511483e-12 -3.76947582666435 4.09541818232216e-14 miRNATAP -0.612876579587926 2.13309385488441e-05 NA NA NA hsa-let-7i-5p PLCB4 0.412877696970403 0.00622731051981756 -3.76947582666435 4.09541818232216e-14 miRNATAP -0.759861175681747 5.3771519085834e-06 NA NA NA hsa-miR-16-2-3p PLCB4 2.31623086727196 4.29838149388188e-20 -3.76947582666435 4.09541818232216e-14 mirMAP -0.822927554545324 1.05250980874373e-19 NA NA NA hsa-miR-23a-3p PLCB4 1.00493340843378 2.55313889288924e-08 -3.76947582666435 4.09541818232216e-14 miRNATAP -1.16100967819954 1.63098743065023e-18 NA NA NA hsa-miR-26b-5p PLCB4 0.885393662798425 3.2116297961629e-06 -3.76947582666435 4.09541818232216e-14 miRNAWalker2_validate -0.77108874483763 2.27781944637492e-09 NA NA NA hsa-miR-361-5p PLCB4 0.971859117235239 5.30236555707088e-09 -3.76947582666435 4.09541818232216e-14 miRanda -0.459154534994574 0.00209783633322442 NA NA NA hsa-miR-450b-5p PLCB4 1.69244418548325 1.68064054148881e-10 -3.76947582666435 4.09541818232216e-14 PITA;mirMAP -0.350535095559098 0.000138134023890591 NA NA NA hsa-miR-454-3p PLCB4 2.47234127820054 1.12878018736016e-21 -3.76947582666435 4.09541818232216e-14 miRNATAP -0.578117115173462 4.64511654720209e-10 NA NA NA hsa-miR-455-5p PLCB4 2.2582442061694 1.43472128037398e-13 -3.76947582666435 4.09541818232216e-14 PITA;miRanda -0.612873661319147 1.38103686478768e-15 NA NA NA hsa-miR-590-3p PLCB4 2.59289455139753 1.03200520972022e-21 -3.76947582666435 4.09541818232216e-14 miRanda -0.612962269746204 3.23888281679726e-12 NA NA NA hsa-miR-944 PLCB4 2.91186649218281 1.31574753528144e-06 -3.76947582666435 4.09541818232216e-14 mirMAP -0.335476024390202 1.67898371983472e-16 NA NA NA hsa-miR-361-5p PPP3CB 0.971859117235239 5.30236555707088e-09 -1.03671584843429 6.12489584217064e-15 miRanda -0.319599472524393 7.32960352437588e-17 NA NA NA hsa-miR-125a-5p PRICKLE1 0.599529391575274 0.0102300147180307 -1.64440101214105 0.000132852800511825 miRanda -0.485707966204348 4.90641983848895e-08 NA NA NA hsa-miR-141-3p PRICKLE1 5.02396127982626 2.19224509139725e-24 -1.64440101214105 0.000132852800511825 TargetScan -0.396289457266669 8.83434530890621e-26 NA NA NA hsa-miR-17-5p PRICKLE1 3.2710598467455 9.93128340539455e-27 -1.64440101214105 0.000132852800511825 miRNAWalker2_validate -0.489501669242094 4.60900383839463e-15 NA NA NA hsa-miR-192-5p PRICKLE1 2.69002528723195 1.22990188194432e-16 -1.64440101214105 0.000132852800511825 miRNAWalker2_validate -0.455771322391911 4.6556373418372e-14 NA NA NA hsa-miR-30b-5p PRICKLE1 0.800822374912712 0.000133601914525413 -1.64440101214105 0.000132852800511825 mirMAP -0.556999598749772 1.74176304546946e-08 NA NA NA hsa-miR-30c-5p PRICKLE1 0.778774633108 0.000285599212429136 -1.64440101214105 0.000132852800511825 miRNATAP -0.690897609672426 4.39705498162092e-13 NA NA NA hsa-miR-30d-5p PRICKLE1 0.675423997639582 0.00270618816039773 -1.64440101214105 0.000132852800511825 miRNATAP -0.800379169580136 4.22770315021246e-19 NA NA NA hsa-miR-330-3p PRICKLE1 0.876747334239085 0.00073709016089703 -1.64440101214105 0.000132852800511825 mirMAP;miRNATAP -0.622179397459892 1.62080967848238e-15 NA NA NA hsa-miR-3607-3p PRICKLE1 2.68532138541128 5.66716351955047e-14 -1.64440101214105 0.000132852800511825 miRNATAP -0.42357423492522 9.31132101711317e-14 NA NA NA hsa-miR-361-5p PRICKLE1 0.971859117235239 5.30236555707088e-09 -1.64440101214105 0.000132852800511825 miRanda -0.963716571594244 2.51074214624177e-15 NA NA NA hsa-miR-532-5p PRICKLE1 1.55697650978597 1.57884735535196e-11 -1.64440101214105 0.000132852800511825 miRNATAP -0.573355511222263 5.09728697524232e-11 NA NA NA hsa-miR-582-5p PRICKLE1 0.609226359812689 0.032988717891497 -1.64440101214105 0.000132852800511825 miRNATAP -0.453563873692779 3.28256113485855e-10 NA NA NA hsa-let-7a-3p PRICKLE2 1.42015538786275 7.03375209382654e-13 -2.50492561876767 7.67759900282699e-16 mirMAP -0.539207780568871 8.89168214926097e-13 NA NA NA hsa-let-7b-3p PRICKLE2 0.868207752019623 1.30460056774366e-05 -2.50492561876767 7.67759900282699e-16 mirMAP -0.328335792282048 2.4936781253752e-05 NA NA NA hsa-miR-10b-3p PRICKLE2 0.77597971642517 0.00264877454133753 -2.50492561876767 7.67759900282699e-16 mirMAP -0.336029709578612 1.70612906836132e-08 NA NA NA hsa-miR-130b-5p PRICKLE2 2.9963110846538 1.98883029416455e-18 -2.50492561876767 7.67759900282699e-16 mirMAP -0.418794308513175 8.87186562840989e-23 NA NA NA hsa-miR-148b-3p PRICKLE2 1.97815018171325 6.07715327281595e-26 -2.50492561876767 7.67759900282699e-16 MirTarget;miRNATAP -0.785948003844471 3.4941229577441e-26 NA NA NA hsa-miR-15b-3p PRICKLE2 2.33847028227712 4.29662877950836e-19 -2.50492561876767 7.67759900282699e-16 mirMAP -0.628334141188587 1.70338531742982e-32 NA NA NA hsa-miR-16-2-3p PRICKLE2 2.31623086727196 4.29838149388188e-20 -2.50492561876767 7.67759900282699e-16 mirMAP -0.62986755142219 3.39607505724523e-30 NA NA NA hsa-miR-181a-2-3p PRICKLE2 2.19062681262366 3.81790102612782e-13 -2.50492561876767 7.67759900282699e-16 MirTarget -0.341307067912297 3.67551574898414e-12 NA NA NA hsa-miR-181a-5p PRICKLE2 2.29556023480783 1.8138457900616e-21 -2.50492561876767 7.67759900282699e-16 mirMAP;miRNATAP -0.306150029056787 5.47331855122461e-07 NA NA NA hsa-miR-181b-5p PRICKLE2 2.49307679431293 3.92829250217627e-20 -2.50492561876767 7.67759900282699e-16 mirMAP;miRNATAP -0.306972546968241 1.49605086429176e-08 NA NA NA hsa-miR-182-5p PRICKLE2 3.53923166221814 5.07781258121574e-21 -2.50492561876767 7.67759900282699e-16 MirTarget -0.402997008407211 1.15936336737611e-27 NA NA NA hsa-miR-186-5p PRICKLE2 1.47445398888668 3.0781726595413e-15 -2.50492561876767 7.67759900282699e-16 MirTarget -0.647366335276188 1.98790215551895e-16 NA NA NA hsa-miR-18a-5p PRICKLE2 3.78535678765353 3.72446596213886e-26 -2.50492561876767 7.67759900282699e-16 MirTarget -0.397503888220548 4.73287579586341e-22 NA NA NA hsa-miR-194-5p PRICKLE2 1.8992998339217 3.76507853301977e-10 -2.50492561876767 7.67759900282699e-16 miRNATAP -0.332545564558026 1.55955134652075e-11 NA NA NA hsa-miR-197-3p PRICKLE2 1.75733174019505 8.88576793100499e-13 -2.50492561876767 7.67759900282699e-16 mirMAP -0.523811308936105 1.30426908928557e-18 NA NA NA hsa-miR-19a-3p PRICKLE2 3.42309334186656 3.02671914353412e-28 -2.50492561876767 7.67759900282699e-16 MirTarget;miRNATAP -0.448020028810871 7.15751272213005e-24 NA NA NA hsa-miR-19b-3p PRICKLE2 2.49529833021187 1.57028265846699e-23 -2.50492561876767 7.67759900282699e-16 MirTarget;miRNATAP -0.583853366206712 1.70592670236508e-25 NA NA NA hsa-miR-21-5p PRICKLE2 2.73773305747971 1.38864982139576e-43 -2.50492561876767 7.67759900282699e-16 miRNAWalker2_validate;MirTarget -0.32154392485735 5.80431134032331e-06 NA NA NA hsa-miR-32-3p PRICKLE2 2.02436999565685 5.94091197945307e-09 -2.50492561876767 7.67759900282699e-16 MirTarget;mirMAP -0.41999543628016 3.4862581324979e-18 NA NA NA hsa-miR-320a PRICKLE2 0.438165828017084 0.0390159073347133 -2.50492561876767 7.67759900282699e-16 mirMAP -0.339242707665728 3.8402629388289e-06 NA NA NA hsa-miR-320b PRICKLE2 1.55692969039548 1.41071034251915e-08 -2.50492561876767 7.67759900282699e-16 mirMAP -0.411686480520056 3.85537610846259e-14 NA NA NA hsa-miR-330-3p PRICKLE2 0.876747334239085 0.00073709016089703 -2.50492561876767 7.67759900282699e-16 MirTarget -0.333568983374932 1.69001575512376e-08 NA NA NA hsa-miR-330-5p PRICKLE2 1.15100069700871 4.85551805046014e-07 -2.50492561876767 7.67759900282699e-16 miRanda;miRNATAP -0.405437403051796 1.12063713986028e-09 NA NA NA hsa-miR-33a-3p PRICKLE2 1.72765312072219 1.51784443453521e-07 -2.50492561876767 7.67759900282699e-16 mirMAP -0.384866357837623 1.19918403955929e-14 NA NA NA hsa-miR-33a-5p PRICKLE2 3.79671563098419 1.15966309820345e-18 -2.50492561876767 7.67759900282699e-16 MirTarget -0.389559001780461 2.99838847240645e-28 NA NA NA hsa-miR-361-5p PRICKLE2 0.971859117235239 5.30236555707088e-09 -2.50492561876767 7.67759900282699e-16 MirTarget;PITA;miRanda;miRNATAP -0.720946809339488 1.62609363058102e-15 NA NA NA hsa-miR-374a-3p PRICKLE2 0.533309330504947 0.00192918429705142 -2.50492561876767 7.67759900282699e-16 MirTarget;miRNATAP -0.464429679965743 3.07399534922093e-07 NA NA NA hsa-miR-421 PRICKLE2 1.17791565395543 6.78526676976629e-06 -2.50492561876767 7.67759900282699e-16 miRanda -0.36305743489363 4.65091550666742e-10 NA NA NA hsa-miR-484 PRICKLE2 1.81844463411787 1.82951571230938e-15 -2.50492561876767 7.67759900282699e-16 miRNATAP -0.606447560779501 6.86854418780793e-22 NA NA NA hsa-miR-576-5p PRICKLE2 2.20467023993664 3.4053475193793e-19 -2.50492561876767 7.67759900282699e-16 mirMAP -0.488017551727603 9.30335022190535e-17 NA NA NA hsa-miR-589-3p PRICKLE2 2.51971841868825 2.39125940264107e-11 -2.50492561876767 7.67759900282699e-16 MirTarget -0.312234425882489 3.45417826036575e-12 NA NA NA hsa-miR-589-5p PRICKLE2 1.71990116752371 8.310889042056e-14 -2.50492561876767 7.67759900282699e-16 MirTarget;miRNATAP -0.487305559975744 2.99464301103798e-14 NA NA NA hsa-miR-590-3p PRICKLE2 2.59289455139753 1.03200520972022e-21 -2.50492561876767 7.67759900282699e-16 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.505549166522866 5.61908122712949e-21 NA NA NA hsa-miR-590-5p PRICKLE2 3.18300989862077 2.06813568597893e-26 -2.50492561876767 7.67759900282699e-16 MirTarget;PITA;miRanda -0.484977141849688 2.22683032544822e-24 NA NA NA hsa-miR-624-5p PRICKLE2 1.47043111118159 8.25080691741182e-09 -2.50492561876767 7.67759900282699e-16 mirMAP -0.387758298962577 2.8636467142759e-10 NA NA NA hsa-miR-628-5p PRICKLE2 0.799263053510813 2.28892357418044e-05 -2.50492561876767 7.67759900282699e-16 PITA;miRNATAP -0.319429805077997 0.000110570682635733 NA NA NA hsa-miR-629-3p PRICKLE2 2.36570947321815 1.33458201201618e-11 -2.50492561876767 7.67759900282699e-16 MirTarget -0.329679846764565 7.23182440667344e-12 NA NA NA hsa-miR-7-1-3p PRICKLE2 1.84950311431067 1.25300363397654e-13 -2.50492561876767 7.67759900282699e-16 MirTarget -0.55473523939828 1.1301405644128e-21 NA NA NA hsa-miR-181a-5p PRKCA 2.29556023480783 1.8138457900616e-21 -1.04253532292201 0.000330447904822586 mirMAP -0.332076264197257 1.58885695452918e-09 NA NA NA hsa-miR-186-5p PRKCA 1.47445398888668 3.0781726595413e-15 -1.04253532292201 0.000330447904822586 miRNATAP -0.372737117584225 3.41129073481267e-07 NA NA NA hsa-miR-141-5p PRKCB 3.81419396518882 3.21977359736126e-18 -3.26032077132529 1.38524824909011e-12 mirMAP -0.448157631252767 6.03056466923945e-21 NA NA NA hsa-miR-16-2-3p PRKCB 2.31623086727196 4.29838149388188e-20 -3.26032077132529 1.38524824909011e-12 mirMAP -0.508156111029493 2.858696818642e-09 NA NA NA hsa-miR-186-5p PRKCB 1.47445398888668 3.0781726595413e-15 -3.26032077132529 1.38524824909011e-12 mirMAP -0.79180135498475 1.36020814670637e-11 NA NA NA hsa-miR-194-5p PRKCB 1.8992998339217 3.76507853301977e-10 -3.26032077132529 1.38524824909011e-12 miRNATAP -0.485081827287577 2.16525492854143e-11 NA NA NA hsa-miR-200b-3p PRKCB 3.78235093249346 3.18343003239465e-14 -3.26032077132529 1.38524824909011e-12 MirTarget -0.450279840251611 3.58923445938153e-27 NA NA NA hsa-miR-200c-3p PRKCB 3.50132673580082 2.42716349086937e-15 -3.26032077132529 1.38524824909011e-12 MirTarget;miRNATAP -0.48715771688849 5.01263551249731e-25 NA NA NA hsa-miR-23a-3p PRKCB 1.00493340843378 2.55313889288924e-08 -3.26032077132529 1.38524824909011e-12 mirMAP -0.422834753714352 0.000810959402297788 NA NA NA hsa-miR-24-3p PRKCB 0.99989036772428 1.35595013650376e-07 -3.26032077132529 1.38524824909011e-12 miRNATAP -0.496540154032259 3.34685620532722e-05 NA NA NA hsa-miR-26b-5p PRKCB 0.885393662798425 3.2116297961629e-06 -3.26032077132529 1.38524824909011e-12 mirMAP -0.316938073060502 0.0085744560045255 NA NA NA hsa-miR-29b-2-5p PRKCB 0.910668640983475 0.00666655585493488 -3.26032077132529 1.38524824909011e-12 mirMAP -0.34510237827648 3.08410596869229e-07 NA NA NA hsa-miR-30b-5p PRKCB 0.800822374912712 0.000133601914525413 -3.26032077132529 1.38524824909011e-12 mirMAP -0.425134820547528 9.53655468608799e-05 NA NA NA hsa-miR-30c-5p PRKCB 0.778774633108 0.000285599212429136 -3.26032077132529 1.38524824909011e-12 mirMAP -0.468954366973799 1.00031056614682e-05 NA NA NA hsa-miR-30d-3p PRKCB 0.977747550180601 4.3048212205381e-05 -3.26032077132529 1.38524824909011e-12 mirMAP -0.529262539307465 2.03079793114812e-08 NA NA NA hsa-miR-30d-5p PRKCB 0.675423997639582 0.00270618816039773 -3.26032077132529 1.38524824909011e-12 mirMAP -0.603674275615055 1.78624617709124e-09 NA NA NA hsa-miR-335-3p PRKCB 3.08791651139852 5.31309869723517e-12 -3.26032077132529 1.38524824909011e-12 mirMAP -0.330098295724148 1.15037296640229e-11 NA NA NA hsa-miR-3607-3p PRKCB 2.68532138541128 5.66716351955047e-14 -3.26032077132529 1.38524824909011e-12 miRNATAP -0.309871089079837 9.51108883796167e-07 NA NA NA hsa-miR-361-5p PRKCB 0.971859117235239 5.30236555707088e-09 -3.26032077132529 1.38524824909011e-12 MirTarget;miRanda;miRNATAP -1.08630383105364 2.58179254217249e-16 NA NA NA hsa-miR-429 PRKCB 4.48815175680773 2.44117492218206e-17 -3.26032077132529 1.38524824909011e-12 MirTarget;miRanda;miRNATAP -0.42521096062837 6.46582126393278e-28 NA NA NA hsa-miR-450b-5p PRKCB 1.69244418548325 1.68064054148881e-10 -3.26032077132529 1.38524824909011e-12 miRNATAP -0.300053601902219 0.00039020696289519 NA NA NA hsa-miR-484 PRKCB 1.81844463411787 1.82951571230938e-15 -3.26032077132529 1.38524824909011e-12 MirTarget;miRNATAP -0.703163397284051 1.07982697132474e-13 NA NA NA hsa-miR-491-5p PRKCB 0.615770352820862 0.0418295628761654 -3.26032077132529 1.38524824909011e-12 miRanda -0.381404660757775 2.20068611106109e-06 NA NA NA hsa-miR-589-3p PRKCB 2.51971841868825 2.39125940264107e-11 -3.26032077132529 1.38524824909011e-12 mirMAP -0.452218517865859 7.06052991667871e-12 NA NA NA hsa-miR-589-5p PRKCB 1.71990116752371 8.310889042056e-14 -3.26032077132529 1.38524824909011e-12 mirMAP -0.544486942502154 1.22125132593852e-08 NA NA NA hsa-miR-590-3p PRKCB 2.59289455139753 1.03200520972022e-21 -3.26032077132529 1.38524824909011e-12 mirMAP -0.388404821887359 2.22817064825303e-06 NA NA NA hsa-miR-590-5p PRKCB 3.18300989862077 2.06813568597893e-26 -3.26032077132529 1.38524824909011e-12 miRanda -0.553979313426607 1.10231423603006e-14 NA NA NA hsa-miR-7-1-3p PRKCB 1.84950311431067 1.25300363397654e-13 -3.26032077132529 1.38524824909011e-12 mirMAP -0.468511892026853 1.14425525890782e-07 NA NA NA hsa-miR-1301-3p SFRP1 2.54959518791507 5.26618591274892e-18 -4.72165743596444 1.94213340952985e-11 MirTarget -0.929647366224829 2.27335164851971e-17 NA NA NA hsa-miR-144-3p SFRP1 0.658119849508907 0.146943823997989 -4.72165743596444 1.94213340952985e-11 MirTarget;miRNATAP -0.307330683826125 0.000100475665353503 NA NA NA hsa-miR-16-1-3p SFRP1 2.56983217111073 3.02262181237943e-20 -4.72165743596444 1.94213340952985e-11 MirTarget -0.991671709293944 6.59532238581082e-17 NA NA NA hsa-miR-182-5p SFRP1 3.53923166221814 5.07781258121574e-21 -4.72165743596444 1.94213340952985e-11 mirMAP -0.689760445961909 6.52748321080623e-16 NA NA NA hsa-miR-19b-1-5p SFRP1 2.57951428759379 4.31576118703427e-20 -4.72165743596444 1.94213340952985e-11 MirTarget -0.808788841622436 1.27899660304967e-11 NA NA NA hsa-miR-26b-3p SFRP1 2.18464160365372 2.11543189388328e-18 -4.72165743596444 1.94213340952985e-11 MirTarget -1.1751124326119 7.4696422523186e-20 NA NA NA hsa-miR-27a-3p SFRP1 1.66542180327138 4.93775737894805e-13 -4.72165743596444 1.94213340952985e-11 MirTarget;miRNATAP -0.517297481926742 0.000463587731630782 NA NA NA hsa-miR-30d-3p SFRP1 0.977747550180601 4.3048212205381e-05 -4.72165743596444 1.94213340952985e-11 miRNATAP -0.812619782319965 1.61238813761418e-08 NA NA NA hsa-miR-328-3p SFRP1 0.596804159297544 0.013858523511843 -4.72165743596444 1.94213340952985e-11 MirTarget -0.806049045586438 1.52940471916615e-08 NA NA NA hsa-miR-33a-3p SFRP1 1.72765312072219 1.51784443453521e-07 -4.72165743596444 1.94213340952985e-11 MirTarget -0.829475588580487 1.30601007666134e-13 NA NA NA hsa-miR-429 SFRP1 4.48815175680773 2.44117492218206e-17 -4.72165743596444 1.94213340952985e-11 miRNATAP -0.527828848274553 3.5454964050295e-18 NA NA NA hsa-miR-484 SFRP1 1.81844463411787 1.82951571230938e-15 -4.72165743596444 1.94213340952985e-11 MirTarget -0.997642924789862 5.9055489271025e-12 NA NA NA hsa-miR-501-5p SFRP1 1.93654809410041 1.3779381780759e-10 -4.72165743596444 1.94213340952985e-11 mirMAP -0.479591960160584 3.64262607664923e-05 NA NA NA hsa-miR-576-5p SFRP1 2.20467023993664 3.4053475193793e-19 -4.72165743596444 1.94213340952985e-11 MirTarget;PITA -0.995471337489543 5.60062584414907e-14 NA NA NA hsa-miR-625-5p SFRP1 1.42540152147292 1.95797147911206e-06 -4.72165743596444 1.94213340952985e-11 MirTarget -0.49096169965567 0.000101372757547789 NA NA NA hsa-miR-7-1-3p SFRP1 1.84950311431067 1.25300363397654e-13 -4.72165743596444 1.94213340952985e-11 MirTarget;mirMAP -0.762107203560682 1.43537728973781e-08 NA NA NA hsa-miR-940 SFRP1 3.21011374578759 2.7923171128495e-14 -4.72165743596444 1.94213340952985e-11 MirTarget -0.686367126934405 4.68712399228061e-16 NA NA NA hsa-miR-96-5p SFRP1 4.89433085814374 1.92000659886961e-31 -4.72165743596444 1.94213340952985e-11 mirMAP -0.669139763083358 1.28798090621278e-18 NA NA NA hsa-let-7a-3p SFRP2 1.42015538786275 7.03375209382654e-13 -4.16178735068602 3.31506527735546e-05 miRNATAP -0.89281914791746 0.000227340302932607 NA NA NA hsa-miR-129-5p SFRP2 -0.524170159980738 0.222582956006346 -4.16178735068602 3.31506527735546e-05 miRanda -0.630160932622878 3.86233153372382e-08 NA NA NA hsa-miR-33a-3p SFRP2 1.72765312072219 1.51784443453521e-07 -4.16178735068602 3.31506527735546e-05 miRNATAP -1.62705268702629 7.92231939632561e-27 NA NA NA hsa-miR-421 SFRP2 1.17791565395543 6.78526676976629e-06 -4.16178735068602 3.31506527735546e-05 miRanda -1.01500630773474 3.39180166966394e-08 NA NA NA hsa-miR-582-5p SFRP2 0.609226359812689 0.032988717891497 -4.16178735068602 3.31506527735546e-05 miRNATAP -1.18412195898295 1.52956890812353e-12 NA NA NA hsa-miR-590-3p SFRP2 2.59289455139753 1.03200520972022e-21 -4.16178735068602 3.31506527735546e-05 miRanda -0.97105911982824 2.69858165021412e-08 NA NA NA hsa-miR-129-5p SFRP4 -0.524170159980738 0.222582956006346 -1.41812614850623 0.144139876921528 miRanda -0.637222711825178 6.50533571239219e-09 NA NA NA hsa-miR-135b-5p SFRP4 3.62510365056501 1.09148980810091e-10 -1.41812614850623 0.144139876921528 MirTarget -0.400250647773767 3.11844917971521e-06 NA NA NA hsa-miR-144-5p SFRP4 0.195856574290527 0.61856475838049 -1.41812614850623 0.144139876921528 MirTarget -0.941974526813176 3.50144316140929e-16 NA NA NA hsa-miR-26b-5p SFRP4 0.885393662798425 3.2116297961629e-06 -1.41812614850623 0.144139876921528 miRNAWalker2_validate -1.21337911678089 7.24653678773283e-07 NA NA NA hsa-miR-3607-3p SFRP4 2.68532138541128 5.66716351955047e-14 -1.41812614850623 0.144139876921528 MirTarget -0.849736907270799 3.45388748105254e-11 NA NA NA hsa-miR-375 SFRP4 1.13910305294079 0.0512283522214186 -1.41812614850623 0.144139876921528 miRanda -0.337279266167069 2.30235054354617e-05 NA NA NA hsa-miR-429 SFRP4 4.48815175680773 2.44117492218206e-17 -1.41812614850623 0.144139876921528 miRanda -0.661619050561664 8.57873647657987e-16 NA NA NA hsa-miR-532-5p SFRP4 1.55697650978597 1.57884735535196e-11 -1.41812614850623 0.144139876921528 MirTarget -0.931213634256187 2.56628880190551e-06 NA NA NA hsa-miR-664a-3p SFRP4 0.634721925861133 0.00520070178640421 -1.41812614850623 0.144139876921528 mirMAP -1.03890413731503 4.31949530349031e-07 NA NA NA hsa-miR-944 SFRP4 2.91186649218281 1.31574753528144e-06 -1.41812614850623 0.144139876921528 mirMAP -0.536101827755114 5.07239766557947e-12 NA NA NA hsa-miR-339-5p SFRP5 2.68710938429893 3.03134080808154e-16 -4.00418767619732 1.33283270821635e-12 miRanda -0.426709848250993 1.63047977022509e-07 NA NA NA hsa-miR-132-3p SMAD3 0.156276992635384 0.408190812100704 -0.145068391221315 0.569239559252949 mirMAP -0.307625427852275 2.61092084929535e-06 NA NA NA hsa-miR-330-5p SOX17 1.15100069700871 4.85551805046014e-07 -2.94798887132292 6.52451561011194e-21 miRanda -0.30637343726308 8.69430797835861e-06 NA NA NA hsa-miR-421 SOX17 1.17791565395543 6.78526676976629e-06 -2.94798887132292 6.52451561011194e-21 miRanda -0.30262015358656 4.92995991235237e-07 NA NA NA hsa-miR-590-3p SOX17 2.59289455139753 1.03200520972022e-21 -2.94798887132292 6.52451561011194e-21 miRanda;miRNATAP -0.448317394761125 1.03655081728629e-15 NA NA NA hsa-miR-590-5p SOX17 3.18300989862077 2.06813568597893e-26 -2.94798887132292 6.52451561011194e-21 miRanda -0.408104262709017 2.5149436420718e-16 NA NA NA hsa-miR-106b-5p TCF7L1 2.46782146831112 1.36171495805632e-23 -1.29563210038614 0.00022110689990566 MirTarget -0.484981855840182 3.28026578455762e-14 NA NA NA hsa-miR-15b-3p TCF7L1 2.33847028227712 4.29662877950836e-19 -1.29563210038614 0.00022110689990566 miRNATAP -0.300469437837364 1.27786211803164e-06 NA NA NA hsa-miR-200a-3p TCF7L1 4.59434485520731 6.38952518573476e-18 -1.29563210038614 0.00022110689990566 miRNAWalker2_validate -0.31712696382727 2.57417137844588e-28 NA NA NA hsa-miR-200b-3p TCF7L1 3.78235093249346 3.18343003239465e-14 -1.29563210038614 0.00022110689990566 miRNAWalker2_validate -0.344042033030514 1.2723812194927e-28 NA NA NA hsa-miR-200c-3p TCF7L1 3.50132673580082 2.42716349086937e-15 -1.29563210038614 0.00022110689990566 miRNAWalker2_validate -0.321512044267134 2.09544895880279e-19 NA NA NA hsa-miR-30b-3p TCF7L1 0.834142820354026 0.000972582820878813 -1.29563210038614 0.00022110689990566 MirTarget -0.334944599332039 6.20751141723943e-07 NA NA NA hsa-miR-30d-3p TCF7L1 0.977747550180601 4.3048212205381e-05 -1.29563210038614 0.00022110689990566 miRNATAP -0.376148637052463 9.58674800435899e-08 NA NA NA hsa-miR-429 TCF7L1 4.48815175680773 2.44117492218206e-17 -1.29563210038614 0.00022110689990566 miRNAWalker2_validate -0.314442027101828 2.17867907624385e-27 NA NA NA hsa-miR-93-5p TCF7L1 3.03961860136032 1.11672209617395e-24 -1.29563210038614 0.00022110689990566 MirTarget -0.400191107813803 3.80432743383064e-14 NA NA NA hsa-miR-148b-3p WNT10B 1.97815018171325 6.07715327281595e-26 -1.27203222851497 0.00216255711887601 MirTarget -0.335932330151756 0.000961494889825557 NA NA NA hsa-miR-320a WNT10B 0.438165828017084 0.0390159073347133 -1.27203222851497 0.00216255711887601 miRanda -0.308659404441888 0.00123166210670891 NA NA NA hsa-miR-98-5p WNT10B 1.11154309866014 1.24143909012085e-08 -1.27203222851497 0.00216255711887601 miRNAWalker2_validate -0.428471972853677 2.63884478727919e-05 NA NA NA hsa-miR-320a WNT11 0.438165828017084 0.0390159073347133 -0.821017630142777 0.174343340060726 miRanda -0.419932472809252 0.00246805866460523 NA NA NA hsa-miR-330-3p WNT11 0.876747334239085 0.00073709016089703 -0.821017630142777 0.174343340060726 miRNATAP -0.630031523186883 1.32892882444745e-08 NA NA NA hsa-miR-429 WNT11 4.48815175680773 2.44117492218206e-17 -0.821017630142777 0.174343340060726 miRNATAP -0.323236245003944 4.91620754160683e-10 NA NA NA hsa-miR-324-5p WNT2 2.95683728155095 1.32960514360912e-20 1.46246443466742 0.00687918143780108 miRanda -0.38757678515523 6.86691469936031e-07 NA NA NA hsa-miR-532-5p WNT2 1.55697650978597 1.57884735535196e-11 1.46246443466742 0.00687918143780108 miRNATAP -0.448940114207323 5.28040850028776e-05 NA NA NA hsa-miR-590-3p WNT2 2.59289455139753 1.03200520972022e-21 1.46246443466742 0.00687918143780108 miRanda;mirMAP -0.329847894616273 0.000497680240546934 NA NA NA hsa-miR-624-5p WNT2 1.47043111118159 8.25080691741182e-09 1.46246443466742 0.00687918143780108 MirTarget -0.373112640327464 0.000392477231594863 NA NA NA hsa-miR-130b-3p WNT2B 3.5350292994509 1.73934183852569e-27 -2.76786035438807 3.62604310321995e-16 MirTarget -0.303083727967098 3.15414419909699e-10 NA NA NA hsa-miR-186-5p WNT2B 1.47445398888668 3.0781726595413e-15 -2.76786035438807 3.62604310321995e-16 mirMAP -0.526224059963912 1.96983492918001e-09 NA NA NA hsa-miR-454-3p WNT2B 2.47234127820054 1.12878018736016e-21 -2.76786035438807 3.62604310321995e-16 MirTarget -0.41394177732075 6.39547989328164e-11 NA NA NA hsa-miR-576-5p WNT2B 2.20467023993664 3.4053475193793e-19 -2.76786035438807 3.62604310321995e-16 mirMAP -0.435613826545259 2.2340672726842e-11 NA NA NA hsa-miR-185-5p WNT5B 2.34016206907488 1.17481626642022e-26 -2.10977851058083 2.85645296158293e-05 miRNAWalker2_validate -0.60642348108017 6.66154666586742e-09 NA NA NA hsa-miR-28-5p WNT5B 0.230152919654905 0.0742909586754846 -2.10977851058083 2.85645296158293e-05 miRanda -0.530836498754109 0.00709692972406734 NA NA NA hsa-miR-15b-5p WNT7A 1.57112623124278 9.14247846750597e-13 1.48380060438584 0.0764894326083681 MirTarget -0.548908791209485 0.00235306455612105 27195958 WNT7A Regulation by miR 15b in Ovarian Cancer; In the present study we report that WNT7A is a direct target of miR-15b in ovarian cancer; We showed that a luciferase reporter containing the putative binding site of miR-15b in the WNT7A 3'-UTR was significantly repressed by miR-15b; Mutation of the putative binding site of miR-15b in the WNT7A 3'-UTR restored luciferase activity; Furthermore miR-15b was able to repress increased levels of TOPFLASH activity by WNT7A but not those induced by S33Y; Additionally miR-15b dose-dependently decreased WNT7A expression; When we evaluated the prognostic impact of WNT7A and miR-15b expression using TCGA datasets a significant inverse correlation in which high-expression of WNT7A and low-expression of miR-15b was associated with reduced survival rates of ovarian cancer patients; These results suggest that WNT7A is post-transcriptionally regulated by miR-15b which could be down-regulated by promoter hypermethylation potentially via DNMT1 in ovarian cancer poor survival ovarian cancer hsa-miR-361-5p WNT7A 0.971859117235239 5.30236555707088e-09 1.48380060438584 0.0764894326083681 MirTarget;PITA;miRanda -0.781472713576135 0.00129094368654843 NA NA NA hsa-miR-140-3p WNT9A 0.0608890720479334 0.727716871248724 -2.06944914631955 1.31351479409276e-06 mirMAP -0.579602489890684 1.58809164562323e-06 NA NA NA hsa-miR-148b-3p WNT9A 1.97815018171325 6.07715327281595e-26 -2.06944914631955 1.31351479409276e-06 mirMAP -0.797484051103519 8.69028922154765e-15 NA NA NA hsa-miR-15a-5p WNT9A 2.34669284378787 1.69544424500258e-23 -2.06944914631955 1.31351479409276e-06 mirMAP -0.523049603269295 3.33612355484908e-10 NA NA NA hsa-miR-15b-5p WNT9A 1.57112623124278 9.14247846750597e-13 -2.06944914631955 1.31351479409276e-06 mirMAP -0.537310487356042 4.9690416749748e-09 NA NA NA hsa-miR-16-5p WNT9A 1.75824877145857 1.68592440033108e-16 -2.06944914631955 1.31351479409276e-06 mirMAP -0.527507066701592 2.02103779015698e-08 NA NA NA hsa-miR-185-3p WNT9A 2.3922478518806 1.3373426768452e-14 -2.06944914631955 1.31351479409276e-06 mirMAP -0.317845522149715 9.19525985946639e-07 NA NA NA hsa-miR-22-3p WNT9A 1.21545661147757 1.61670170137775e-13 -2.06944914631955 1.31351479409276e-06 mirMAP -0.387232862036002 0.00200886957549209 NA NA NA hsa-miR-28-5p WNT9A 0.230152919654905 0.0742909586754846 -2.06944914631955 1.31351479409276e-06 mirMAP -0.499108130649814 0.00291674315897674 NA NA NA hsa-miR-32-5p WNT9A 2.34056473219422 6.24134585974322e-20 -2.06944914631955 1.31351479409276e-06 mirMAP -0.40706330365171 1.50628991198258e-07 NA NA NA hsa-miR-331-3p WNT9A 2.28379581858927 1.99663919173155e-18 -2.06944914631955 1.31351479409276e-06 mirMAP -0.430796168913306 1.56673396070433e-08 NA NA NA hsa-miR-424-5p WNT9A 1.61930224569578 1.89642549274994e-10 -2.06944914631955 1.31351479409276e-06 mirMAP -0.335943130936018 3.02480044382518e-05 NA NA NA hsa-miR-532-3p WNT9A 1.96631878320218 4.53421954361695e-13 -2.06944914631955 1.31351479409276e-06 mirMAP -0.491322601879638 2.44328125497404e-11 NA NA NA hsa-miR-589-3p WNT9A 2.51971841868825 2.39125940264107e-11 -2.06944914631955 1.31351479409276e-06 mirMAP -0.320844220548304 1.47772350028815e-07 NA NA NA