miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-125a-5p APC 0.599529391575274 0.0102300147180307 -0.603984431450045 0.000122196213200349 miRanda -0.206850857172122 1.35649172215922e-10 NA NA NA hsa-miR-148a-3p APC 1.26728238710376 2.52325607402829e-06 -0.603984431450045 0.000122196213200349 miRNAWalker2_validate -0.118159804157767 2.41472154629156e-05 NA NA NA hsa-miR-186-5p APC 1.47445398888668 3.0781726595413e-15 -0.603984431450045 0.000122196213200349 miRNAWalker2_validate -0.195857780898061 7.35879611668229e-07 NA NA NA hsa-miR-21-5p APC 2.73773305747971 1.38864982139576e-43 -0.603984431450045 0.000122196213200349 miRNAWalker2_validate -0.210735008738127 9.09045679037576e-10 23773491;24832083 The prognostic significance of APC gene mutation and miR 21 expression in advanced stage colorectal cancer; The aim of this study was to analyse the association of APC gene mutation and miR-21 expression with clinical outcome in CRC patients; APC gene mutation and expression of APC and miR-21 were analysed by direct DNA sequencing and real-time reverse transcription polymerase chain reaction; APC gene expression was low in CRC and negatively correlated with miR-21 expression and gene mutation; In Taiwan downregulation of the APC gene in CRC correlated with gene mutation and miR-21 upregulation; APC mutation and miR-21 expression could be used to predict the clinical outcome of CRC especially in patients with advanced disease;MicroRNA 21 promotes tumour malignancy via increased nuclear translocation of β catenin and predicts poor outcome in APC mutated but not in APC wild type colorectal cancer; However in our preliminary data the prognostic value of miR-21 levels was observed only in adenomatous polyposis coli APC-mutated tumours not in APC-wild-type tumours; We enrolled 165 colorectal tumour to determine APC mutation miR-21 levels and nuclear β-catenin expression by direct sequencing real-time PCR and immunohistochemistry staging; colorectal cancer;colorectal cancer hsa-miR-320a APC 0.438165828017084 0.0390159073347133 -0.603984431450045 0.000122196213200349 miRanda -0.103841534148773 0.00418426564639978 NA NA NA hsa-miR-338-3p APC 0.453166438193782 0.144583389707558 -0.603984431450045 0.000122196213200349 miRanda -0.108366079373357 9.49384870738723e-06 NA NA NA hsa-miR-501-3p APC 1.83132758513743 1.10971547702065e-10 -0.603984431450045 0.000122196213200349 TargetScan -0.113665798109815 1.4428194665465e-05 NA NA NA hsa-miR-590-3p APC 2.59289455139753 1.03200520972022e-21 -0.603984431450045 0.000122196213200349 PITA;miRanda;mirMAP;miRNATAP -0.100123284836768 0.0002767508066816 NA NA NA hsa-miR-28-5p APC2 0.230152919654905 0.0742909586754846 0.382466786710938 0.250734891357193 mirMAP -0.367063763696686 0.00439410600608565 NA NA NA hsa-let-7a-3p AXIN2 1.42015538786275 7.03375209382654e-13 -1.6986287186272 5.56904404371908e-05 miRNATAP -0.580881072981708 7.52786609329052e-09 NA NA NA hsa-let-7b-3p AXIN2 0.868207752019623 1.30460056774366e-05 -1.6986287186272 5.56904404371908e-05 miRNATAP -0.466094148302635 5.47361078751581e-06 NA NA NA hsa-let-7g-3p AXIN2 3.26398061402445 3.96263126107645e-25 -1.6986287186272 5.56904404371908e-05 MirTarget -0.333037817887653 9.55083906918248e-08 NA NA NA hsa-miR-103a-3p AXIN2 1.44083190496858 1.53799939616416e-13 -1.6986287186272 5.56904404371908e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.432944543888631 2.49508578477517e-05 NA NA NA hsa-miR-107 AXIN2 1.30977326593435 1.30372468603965e-11 -1.6986287186272 5.56904404371908e-05 miRTarBase;MirTarget;PITA;miRanda;miRNATAP -0.497419239480003 1.65377519483307e-06 26191213 miR 107 promotes hepatocellular carcinoma cell proliferation by targeting Axin2; At the molecular level our results suggested that expression of Axin2 was negatively regulated by miR-107; Our observations suggested that miR-107 could promote HCC cells proliferation via targeting Axin2 and might represent a potential therapeutic target for HCC liver cancer hsa-miR-144-3p AXIN2 0.658119849508907 0.146943823997989 -1.6986287186272 5.56904404371908e-05 MirTarget -0.271648120794949 3.48662016244501e-09 NA NA NA hsa-miR-15a-5p AXIN2 2.34669284378787 1.69544424500258e-23 -1.6986287186272 5.56904404371908e-05 MirTarget;miRNATAP -0.480955940416503 4.33519973886455e-09 26252081 The combination of miR-15a and AXIN2 significantly improved the diagnostic accuracy thyroid cancer hsa-miR-15b-5p AXIN2 1.57112623124278 9.14247846750597e-13 -1.6986287186272 5.56904404371908e-05 miRTarBase;MirTarget;miRNATAP -0.560514974548682 4.5066035821598e-10 NA NA NA hsa-miR-16-2-3p AXIN2 2.31623086727196 4.29838149388188e-20 -1.6986287186272 5.56904404371908e-05 mirMAP -0.591252000994373 5.59406157801316e-15 NA NA NA hsa-miR-16-5p AXIN2 1.75824877145857 1.68592440033108e-16 -1.6986287186272 5.56904404371908e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.751187601216971 8.49686809333106e-17 NA NA NA hsa-miR-205-5p AXIN2 4.1389800495524 2.05488295686453e-12 -1.6986287186272 5.56904404371908e-05 miRNATAP -0.215833874277093 8.14436018934996e-11 NA NA NA hsa-miR-221-3p AXIN2 0.451556679024397 0.0909808299917811 -1.6986287186272 5.56904404371908e-05 miRNATAP -0.245163690159045 0.00148170922010665 NA NA NA hsa-miR-222-3p AXIN2 0.851783756239071 0.00266783568486918 -1.6986287186272 5.56904404371908e-05 miRNATAP -0.319516992304074 8.90127082603084e-06 NA NA NA hsa-miR-26b-3p AXIN2 2.18464160365372 2.11543189388328e-18 -1.6986287186272 5.56904404371908e-05 MirTarget -0.484074743403874 5.01575452903022e-10 NA NA NA hsa-miR-29a-5p AXIN2 1.46749674755271 3.34605004270294e-07 -1.6986287186272 5.56904404371908e-05 MirTarget -0.371370756814131 5.27889012104867e-07 NA NA NA hsa-miR-34a-5p AXIN2 1.9016323452565 1.43092834643601e-14 -1.6986287186272 5.56904404371908e-05 miRNAWalker2_validate;miRTarBase -0.316389522899683 8.52056660674017e-05 23624843 p53 regulates nuclear GSK 3 levels through miR 34 mediated Axin2 suppression in colorectal cancer cells; Exogenous miR-34a decreases Axin2 UTR-reporter activity through multiple binding sites within the 5' and 3' UTR of Axin2; Further RNA transcripts of miR-34 target were correlated with Axin2 in clinical data set of colorectal cancer patients colorectal cancer hsa-miR-3614-5p AXIN2 2.17736331059655 2.19144831318484e-08 -1.6986287186272 5.56904404371908e-05 MirTarget;miRNATAP -0.268139148154882 4.79077962415622e-07 NA NA NA hsa-miR-424-5p AXIN2 1.61930224569578 1.89642549274994e-10 -1.6986287186272 5.56904404371908e-05 MirTarget;miRNATAP -0.26417909926508 0.000864498183223041 NA NA NA hsa-miR-429 AXIN2 4.48815175680773 2.44117492218206e-17 -1.6986287186272 5.56904404371908e-05 miRanda -0.108406747689685 0.00354861851668096 NA NA NA hsa-miR-590-3p AXIN2 2.59289455139753 1.03200520972022e-21 -1.6986287186272 5.56904404371908e-05 MirTarget;PITA;miRanda;miRNATAP -0.47289600145345 8.55966813825129e-11 NA NA NA hsa-miR-944 AXIN2 2.91186649218281 1.31574753528144e-06 -1.6986287186272 5.56904404371908e-05 MirTarget;PITA;miRNATAP -0.201429219843121 4.01001036442831e-09 NA NA NA hsa-miR-193a-3p BTRC 1.60460546928078 2.86169793322984e-07 -0.199546019056698 0.103646726553756 MirTarget;miRanda -0.120133296395203 4.72730403880987e-11 NA NA NA hsa-miR-22-5p BTRC 1.88011544159252 1.63978222572222e-16 -0.199546019056698 0.103646726553756 miRNATAP -0.10241724919548 4.03610900116379e-05 NA NA NA hsa-miR-361-3p BTRC 1.07367425434318 1.73142774168958e-09 -0.199546019056698 0.103646726553756 MirTarget;PITA;miRNATAP -0.16327609888542 5.3557640072081e-07 NA NA NA hsa-miR-10a-5p CAMK2A 1.15016989191194 0.00372037233992369 -4.13920739991396 5.06813084231462e-14 mirMAP -0.692687780924421 1.2592932316587e-26 NA NA NA hsa-miR-10b-5p CAMK2A -0.155951595811628 0.555006386998027 -4.13920739991396 5.06813084231462e-14 mirMAP -0.806460602294085 1.54003382280288e-15 NA NA NA hsa-miR-1226-3p CAMK2A 1.38118928579963 0.000205503474787488 -4.13920739991396 5.06813084231462e-14 mirMAP -0.68294692904813 3.02529982478943e-17 NA NA NA hsa-miR-125a-5p CAMK2A 0.599529391575274 0.0102300147180307 -4.13920739991396 5.06813084231462e-14 mirMAP -0.749271996568678 9.6185113835477e-11 NA NA NA hsa-miR-129-5p CAMK2A -0.524170159980738 0.222582956006346 -4.13920739991396 5.06813084231462e-14 MirTarget;miRanda -0.267034490825936 3.76880870560483e-05 NA NA NA hsa-miR-130b-5p CAMK2A 2.9963110846538 1.98883029416455e-18 -4.13920739991396 5.06813084231462e-14 mirMAP -0.788484881242789 3.07944990682846e-26 NA NA NA hsa-miR-144-3p CAMK2A 0.658119849508907 0.146943823997989 -4.13920739991396 5.06813084231462e-14 mirMAP -0.345479318710768 1.98227677341234e-08 NA NA NA hsa-miR-148a-3p CAMK2A 1.26728238710376 2.52325607402829e-06 -4.13920739991396 5.06813084231462e-14 miRNATAP -0.448587772260439 7.9925096590489e-06 NA NA NA hsa-miR-148b-5p CAMK2A 2.18024067300781 2.84770452413262e-14 -4.13920739991396 5.06813084231462e-14 mirMAP -1.00860522005724 7.60685952274604e-28 NA NA NA hsa-miR-15b-3p CAMK2A 2.33847028227712 4.29662877950836e-19 -4.13920739991396 5.06813084231462e-14 mirMAP -1.06651894046244 6.28391750734951e-30 NA NA NA hsa-miR-185-5p CAMK2A 2.34016206907488 1.17481626642022e-26 -4.13920739991396 5.06813084231462e-14 mirMAP -1.20773092934503 1.60357939629387e-27 NA NA NA hsa-miR-19b-1-5p CAMK2A 2.57951428759379 4.31576118703427e-20 -4.13920739991396 5.06813084231462e-14 mirMAP -0.864150001209523 4.05477298222864e-21 NA NA NA hsa-miR-205-5p CAMK2A 4.1389800495524 2.05488295686453e-12 -4.13920739991396 5.06813084231462e-14 mirMAP -0.371435532574286 1.57583131673214e-17 NA NA NA hsa-miR-21-3p CAMK2A 2.19296355304364 4.63665722759779e-15 -4.13920739991396 5.06813084231462e-14 MirTarget -0.278040636144698 0.00344593522628056 NA NA NA hsa-miR-25-3p CAMK2A 1.36472605225697 4.83790725935681e-11 -4.13920739991396 5.06813084231462e-14 MirTarget -1.13176632561112 1.24363891592022e-19 NA NA NA hsa-miR-26b-5p CAMK2A 0.885393662798425 3.2116297961629e-06 -4.13920739991396 5.06813084231462e-14 miRNATAP -1.08357243866377 1.08353083251473e-14 NA NA NA hsa-miR-30b-5p CAMK2A 0.800822374912712 0.000133601914525413 -4.13920739991396 5.06813084231462e-14 mirMAP -0.909292779774021 1.20826401788873e-12 NA NA NA hsa-miR-30c-5p CAMK2A 0.778774633108 0.000285599212429136 -4.13920739991396 5.06813084231462e-14 mirMAP -1.03323008829076 6.45287014953708e-17 NA NA NA hsa-miR-30d-5p CAMK2A 0.675423997639582 0.00270618816039773 -4.13920739991396 5.06813084231462e-14 mirMAP -1.36250068562711 1.91289582682655e-33 NA NA NA hsa-miR-30e-5p CAMK2A 1.23904909539663 1.35561917122157e-09 -4.13920739991396 5.06813084231462e-14 mirMAP -1.65598193147241 1.61549017877907e-43 NA NA NA hsa-miR-32-5p CAMK2A 2.34056473219422 6.24134585974322e-20 -4.13920739991396 5.06813084231462e-14 MirTarget -0.856582041487233 4.3042446859323e-18 NA NA NA hsa-miR-331-3p CAMK2A 2.28379581858927 1.99663919173155e-18 -4.13920739991396 5.06813084231462e-14 MirTarget -1.15767161088161 1.62908691123866e-35 NA NA NA hsa-miR-335-5p CAMK2A 1.77247705492746 2.22457658872091e-06 -4.13920739991396 5.06813084231462e-14 mirMAP -0.454419135520998 1.59521837908844e-10 NA NA NA hsa-miR-34a-3p CAMK2A 1.75590866103657 8.02801510630657e-09 -4.13920739991396 5.06813084231462e-14 mirMAP -0.705996788293823 2.02378001337888e-13 NA NA NA hsa-miR-361-3p CAMK2A 1.07367425434318 1.73142774168958e-09 -4.13920739991396 5.06813084231462e-14 mirMAP -0.897217277579828 2.58013522403889e-09 NA NA NA hsa-miR-3614-5p CAMK2A 2.17736331059655 2.19144831318484e-08 -4.13920739991396 5.06813084231462e-14 mirMAP -0.398662975251304 1.85411627951307e-08 NA NA NA hsa-miR-363-3p CAMK2A 1.50575300026701 0.00020976164678918 -4.13920739991396 5.06813084231462e-14 MirTarget -0.473373515026262 4.74898873232694e-13 NA NA NA hsa-miR-3913-5p CAMK2A 2.44353493655328 8.95279496632448e-15 -4.13920739991396 5.06813084231462e-14 mirMAP -0.788064985623782 1.83131242466922e-21 NA NA NA hsa-miR-429 CAMK2A 4.48815175680773 2.44117492218206e-17 -4.13920739991396 5.06813084231462e-14 miRNATAP -0.619342685313725 1.37901796029065e-43 NA NA NA hsa-miR-452-3p CAMK2A 2.42521958420768 4.08754552781156e-07 -4.13920739991396 5.06813084231462e-14 mirMAP -0.269259716042828 1.68744622721554e-06 NA NA NA hsa-miR-582-3p CAMK2A 0.00876844181512659 0.977126166214707 -4.13920739991396 5.06813084231462e-14 mirMAP -0.516161329153302 5.97345257548268e-09 NA NA NA hsa-miR-625-5p CAMK2A 1.42540152147292 1.95797147911206e-06 -4.13920739991396 5.06813084231462e-14 mirMAP -0.484399409318363 9.45286382700684e-07 NA NA NA hsa-miR-7-1-3p CAMK2A 1.84950311431067 1.25300363397654e-13 -4.13920739991396 5.06813084231462e-14 MirTarget -0.814069609431641 4.7841559250915e-15 NA NA NA hsa-miR-92a-3p CAMK2A 2.06460102658973 1.44784291084757e-19 -4.13920739991396 5.06813084231462e-14 MirTarget -1.24024247040884 1.02242820632254e-30 NA NA NA hsa-miR-29c-3p CAMK2B -0.00968972577705429 0.97099586346872 0.669901839915794 0.194250472530958 mirMAP -0.311266024048565 0.000929417287362308 NA NA NA hsa-miR-34a-5p CAMK2B 1.9016323452565 1.43092834643601e-14 0.669901839915794 0.194250472530958 mirMAP -0.262724875681621 0.00749431352388259 NA NA NA hsa-miR-17-3p CAMK2D 2.2704817679209 1.1667437320211e-22 -0.889394756636849 2.56115555479955e-05 miRNATAP -0.148160187773042 0.000453988968273958 NA NA NA hsa-miR-185-5p CAMK2D 2.34016206907488 1.17481626642022e-26 -0.889394756636849 2.56115555479955e-05 miRNATAP -0.205991999560325 2.93705846771855e-06 NA NA NA hsa-miR-186-5p CAMK2D 1.47445398888668 3.0781726595413e-15 -0.889394756636849 2.56115555479955e-05 mirMAP -0.169723278864404 0.00160506356723596 NA NA NA hsa-miR-197-3p CAMK2D 1.75733174019505 8.88576793100499e-13 -0.889394756636849 2.56115555479955e-05 miRNATAP -0.113667966154468 0.00549040903000644 NA NA NA hsa-miR-29b-2-5p CAMK2D 0.910668640983475 0.00666655585493488 -0.889394756636849 2.56115555479955e-05 mirMAP -0.105844947309685 0.000539603832123799 NA NA NA hsa-miR-30c-5p CAMK2D 0.778774633108 0.000285599212429136 -0.889394756636849 2.56115555479955e-05 miRNATAP -0.177208548890034 0.000217766970016237 NA NA NA hsa-miR-30e-5p CAMK2D 1.23904909539663 1.35561917122157e-09 -0.889394756636849 2.56115555479955e-05 miRNATAP -0.188239587041959 0.000150663885279643 NA NA NA hsa-miR-342-3p CAMK2D 1.49115144672245 1.43879249744621e-07 -0.889394756636849 2.56115555479955e-05 miRanda -0.136590070662612 0.000134032205012721 NA NA NA hsa-miR-3607-3p CAMK2D 2.68532138541128 5.66716351955047e-14 -0.889394756636849 2.56115555479955e-05 mirMAP -0.127421985292805 7.83827772970776e-06 NA NA NA hsa-miR-484 CAMK2D 1.81844463411787 1.82951571230938e-15 -0.889394756636849 2.56115555479955e-05 miRNAWalker2_validate -0.183122516221665 2.57365395358782e-05 NA NA NA hsa-miR-582-5p CAMK2D 0.609226359812689 0.032988717891497 -0.889394756636849 2.56115555479955e-05 mirMAP -0.104721603781526 0.00371960958220182 NA NA NA hsa-miR-590-3p CAMK2D 2.59289455139753 1.03200520972022e-21 -0.889394756636849 2.56115555479955e-05 miRanda;mirMAP -0.119965163023114 0.00125702222819631 NA NA NA hsa-miR-7-1-3p CAMK2D 1.84950311431067 1.25300363397654e-13 -0.889394756636849 2.56115555479955e-05 mirMAP -0.163493835233551 4.4018434179472e-05 NA NA NA hsa-miR-127-5p CAMK2G 1.19850695520181 4.10976607177645e-05 -0.516311026754472 0.0077990222135771 MirTarget;PITA;miRNATAP -0.142936770185984 6.66776789936363e-06 NA NA NA hsa-miR-16-2-3p CAMK2G 2.31623086727196 4.29838149388188e-20 -0.516311026754472 0.0077990222135771 mirMAP -0.1709283236042 1.33995073253848e-06 NA NA NA hsa-miR-16-5p CAMK2G 1.75824877145857 1.68592440033108e-16 -0.516311026754472 0.0077990222135771 miRNAWalker2_validate -0.190302430870994 7.36195468094798e-06 NA NA NA hsa-miR-17-3p CAMK2G 2.2704817679209 1.1667437320211e-22 -0.516311026754472 0.0077990222135771 miRNATAP -0.180357101618444 2.52755395086496e-06 NA NA NA hsa-miR-181a-5p CAMK2G 2.29556023480783 1.8138457900616e-21 -0.516311026754472 0.0077990222135771 miRNATAP -0.239155341153834 5.37867919641647e-11 NA NA NA hsa-miR-181b-5p CAMK2G 2.49307679431293 3.92829250217627e-20 -0.516311026754472 0.0077990222135771 miRNATAP -0.208070896805007 1.55077788757059e-10 NA NA NA hsa-miR-193a-5p CAMK2G 0.562511612963676 0.0239254699649222 -0.516311026754472 0.0077990222135771 miRNATAP -0.155690547991653 3.56429164797292e-05 NA NA NA hsa-miR-1976 CAMK2G 2.06550563678192 7.81396978619772e-18 -0.516311026754472 0.0077990222135771 MirTarget -0.197880766201481 1.13205417879991e-07 NA NA NA hsa-miR-29a-3p CAMK2G -0.35074463683376 0.161238718982428 -0.516311026754472 0.0077990222135771 miRNATAP -0.210252192007461 1.59732795588897e-08 NA NA NA hsa-miR-338-3p CAMK2G 0.453166438193782 0.144583389707558 -0.516311026754472 0.0077990222135771 miRNATAP -0.122610394876071 4.79416677765784e-05 NA NA NA hsa-miR-493-3p CAMK2G 0.845355465963442 0.0134856478879555 -0.516311026754472 0.0077990222135771 miRNATAP -0.104296667794277 0.000142530685415309 NA NA NA hsa-miR-495-3p CAMK2G -0.0847115949846082 0.763475496144456 -0.516311026754472 0.0077990222135771 MirTarget -0.13191573880733 8.08473349462124e-05 NA NA NA hsa-miR-590-3p CAMK2G 2.59289455139753 1.03200520972022e-21 -0.516311026754472 0.0077990222135771 miRanda -0.154578259806029 4.55696598095572e-06 NA NA NA hsa-miR-628-5p CAMK2G 0.799263053510813 2.28892357418044e-05 -0.516311026754472 0.0077990222135771 MirTarget;PITA;miRNATAP -0.252876558457605 3.2011481432348e-07 NA NA NA hsa-miR-106a-5p CCND1 2.48882002962836 1.99757727374521e-12 0.0828319966762319 0.840332435689448 MirTarget;miRNATAP -0.278915751904438 2.46069960202024e-07 NA NA NA hsa-miR-15b-5p CCND1 1.57112623124278 9.14247846750597e-13 0.0828319966762319 0.840332435689448 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.2743592470705 0.00190316455907807 NA NA NA hsa-miR-186-5p CCND1 1.47445398888668 3.0781726595413e-15 0.0828319966762319 0.840332435689448 mirMAP -0.319993507741074 0.0020448551843367 NA NA NA hsa-miR-193a-3p CCND1 1.60460546928078 2.86169793322984e-07 0.0828319966762319 0.840332435689448 MirTarget;PITA;miRanda -0.351734964348069 1.30056584701733e-08 NA NA NA hsa-miR-195-5p CCND1 -1.44753678070504 8.70594292149271e-09 0.0828319966762319 0.840332435689448 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.232938095379387 0.00278406868271715 21350001;26631043;25823925 Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer;MiR 195 inhibits the proliferation of human cervical cancer cells by directly targeting cyclin D1; The present study was to evaluate the level of miR-195 and cyclin D1 in CC tissues and cells; We further investigated the molecular mechanisms of miR-195 and cyclin D1 in CC cell lines HeLa and SiHa; Furthermore the expression of miR-195 was inversely proportional to that of cyclin D1 mRNA or protein p = 0.013 p = 0.015 respectively; However the inhibitor of miR-195 promoted the expression of cyclin D1 and cell proliferation; In conclusion our data suggest that miR-195 may have the potential role in treatment of CC patients as well as miR-195 is a novel regulator of invasiveness and tumorigenicity in CC cells by targeting cyclin D1;MicroRNA profiling identifies MiR 195 suppresses osteosarcoma cell metastasis by targeting CCND1; Meanwhile CCND1 was identified as the target gene of miR-195 and further studied; More importantly using real-time PCR we evaluated the expression of miR-195 and CCND1 in osteosarcoma samples from 107 frozen biopsy tissues and 99 formalin- or paraformalin-fixed paraffin-embedded FFPE tissues; Results indicated lowly expressed miR-195 or highly CCND1 correlated with positive overall survival and their expression inversely related to each other; In summary our study suggests miR-195 functions as a tumor metastasis suppressor gene by down-regulating CCND1 and can be used as a potential target in the treatment of osteosarcoma ;;metastasis;poor survival breast cancer;cervical and endocervical cancer;sarcoma hsa-miR-20b-5p CCND1 2.07706563022469 1.10107236083433e-05 0.0828319966762319 0.840332435689448 MirTarget;miRNATAP -0.250774310314038 8.20956147612201e-10 NA NA NA hsa-miR-340-5p CCND1 0.30282999308409 0.157744789519131 0.0828319966762319 0.840332435689448 mirMAP -0.529085780655826 9.29072904979919e-09 NA NA NA hsa-miR-374b-5p CCND1 0.0654362503857184 0.722673188879465 0.0828319966762319 0.840332435689448 miRNAWalker2_validate;MirTarget -0.416222074203323 0.000132219455740898 NA NA NA hsa-miR-497-5p CCND1 0.0257087130056286 0.918145413833358 0.0828319966762319 0.840332435689448 MirTarget;miRNATAP -0.30773442281542 0.000110601843767413 21350001 Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer breast cancer hsa-miR-7-1-3p CCND1 1.84950311431067 1.25300363397654e-13 0.0828319966762319 0.840332435689448 mirMAP -0.247700635127977 0.00138754391814163 NA NA NA hsa-miR-769-3p CCND1 2.19896922202687 5.69250370895053e-12 0.0828319966762319 0.840332435689448 mirMAP -0.231146561837838 0.000210475786569237 NA NA NA hsa-let-7a-3p CCND2 1.42015538786275 7.03375209382654e-13 -2.42747067684236 2.06814828958882e-10 mirMAP -0.440555668621489 2.14967330798537e-06 20418948 MicroRNA let 7a inhibits proliferation of human prostate cancer cells in vitro and in vivo by targeting E2F2 and CCND2 prostate cancer hsa-let-7a-5p CCND2 0.618599506841644 2.76973453058748e-05 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.503238938401113 9.92586197811674e-05 20418948 MicroRNA let 7a inhibits proliferation of human prostate cancer cells in vitro and in vivo by targeting E2F2 and CCND2 prostate cancer hsa-let-7b-3p CCND2 0.868207752019623 1.30460056774366e-05 -2.42747067684236 2.06814828958882e-10 mirMAP -0.292600423696445 0.00203496813099611 NA NA NA hsa-let-7b-5p CCND2 0.604314269683977 0.00140009936153214 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.372644945722985 0.000202758514128247 NA NA NA hsa-let-7e-5p CCND2 0.860104282510173 6.04758298373779e-05 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.254279031336757 0.00390630067355032 NA NA NA hsa-let-7f-1-3p CCND2 1.55054488387679 7.31326775537952e-11 -2.42747067684236 2.06814828958882e-10 mirMAP -0.349075249109793 1.19776506071246e-05 NA NA NA hsa-let-7f-5p CCND2 0.495648727272215 0.00355972741198794 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.395067035409999 0.000431247614557398 NA NA NA hsa-let-7g-5p CCND2 1.20061455355116 1.50237505511483e-12 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.78482657734201 2.2934101130382e-13 NA NA NA hsa-miR-106a-5p CCND2 2.48882002962836 1.99757727374521e-12 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.460265785003224 1.90572227650597e-20 NA NA NA hsa-miR-106b-5p CCND2 2.46782146831112 1.36171495805632e-23 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.723802321113981 4.62852843641777e-26 NA NA NA hsa-miR-10b-3p CCND2 0.77597971642517 0.00264877454133753 -2.42747067684236 2.06814828958882e-10 mirMAP -0.299055149155965 4.03151748542262e-05 NA NA NA hsa-miR-130b-5p CCND2 2.9963110846538 1.98883029416455e-18 -2.42747067684236 2.06814828958882e-10 mirMAP -0.524276006004661 2.15252650149472e-24 NA NA NA hsa-miR-141-3p CCND2 5.02396127982626 2.19224509139725e-24 -2.42747067684236 2.06814828958882e-10 MirTarget;TargetScan -0.336824974322951 8.46453268716016e-23 NA NA NA hsa-miR-151a-3p CCND2 1.24018761527407 1.08839919675408e-07 -2.42747067684236 2.06814828958882e-10 mirMAP -0.618872158164273 1.57062556462901e-15 NA NA NA hsa-miR-15a-5p CCND2 2.34669284378787 1.69544424500258e-23 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.558385276567589 5.78612617845985e-14 NA NA NA hsa-miR-15b-5p CCND2 1.57112623124278 9.14247846750597e-13 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.814047353716774 1.36644748676197e-24 NA NA NA hsa-miR-16-2-3p CCND2 2.31623086727196 4.29838149388188e-20 -2.42747067684236 2.06814828958882e-10 mirMAP -0.524415153934827 5.42085565840902e-14 NA NA NA hsa-miR-16-5p CCND2 1.75824877145857 1.68592440033108e-16 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;miRNATAP -0.624880555696101 7.5948593080299e-14 NA NA NA hsa-miR-17-5p CCND2 3.2710598467455 9.93128340539455e-27 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.576586035201243 5.39762569803648e-26 NA NA NA hsa-miR-181a-2-3p CCND2 2.19062681262366 3.81790102612782e-13 -2.42747067684236 2.06814828958882e-10 mirMAP -0.371385706331271 5.48097191184985e-10 NA NA NA hsa-miR-182-5p CCND2 3.53923166221814 5.07781258121574e-21 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.418107303561313 5.83833309647385e-20 NA NA NA hsa-miR-183-5p CCND2 4.19757025992371 4.79612296318304e-26 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.406097602561121 1.1832385157764e-21 NA NA NA hsa-miR-185-5p CCND2 2.34016206907488 1.17481626642022e-26 -2.42747067684236 2.06814828958882e-10 MirTarget;miRNATAP -0.596214855521239 5.09732672184216e-14 NA NA NA hsa-miR-186-5p CCND2 1.47445398888668 3.0781726595413e-15 -2.42747067684236 2.06814828958882e-10 mirMAP;miRNATAP -0.753228825405404 3.55444659312987e-15 NA NA NA hsa-miR-188-5p CCND2 2.52825126596644 6.78099435999778e-14 -2.42747067684236 2.06814828958882e-10 PITA;mirMAP -0.327199573697285 9.78244941189197e-09 NA NA NA hsa-miR-191-5p CCND2 2.30038190670664 9.93191704545938e-17 -2.42747067684236 2.06814828958882e-10 MirTarget -0.63056469865633 4.58280529094783e-24 NA NA NA hsa-miR-19a-3p CCND2 3.42309334186656 3.02671914353412e-28 -2.42747067684236 2.06814828958882e-10 MirTarget;miRNATAP -0.478555105133488 2.03415225430867e-18 NA NA NA hsa-miR-19b-3p CCND2 2.49529833021187 1.57028265846699e-23 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;MirTarget;miRNATAP -0.644240893236217 5.93065810659583e-21 NA NA NA hsa-miR-200a-3p CCND2 4.59434485520731 6.38952518573476e-18 -2.42747067684236 2.06814828958882e-10 MirTarget -0.322639326506763 1.12744821991113e-23 NA NA NA hsa-miR-20a-5p CCND2 3.15577933619191 4.19753346442454e-25 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.552675029838617 1.98133209896024e-23 NA NA NA hsa-miR-20b-5p CCND2 2.07706563022469 1.10107236083433e-05 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.296015277168294 1.16933542500196e-14 NA NA NA hsa-miR-21-3p CCND2 2.19296355304364 4.63665722759779e-15 -2.42747067684236 2.06814828958882e-10 mirMAP -0.266420777851125 4.25531839718567e-05 NA NA NA hsa-miR-224-3p CCND2 1.87536386559317 6.15140969394846e-05 -2.42747067684236 2.06814828958882e-10 mirMAP -0.234939524450716 1.27567539540633e-08 NA NA NA hsa-miR-26b-5p CCND2 0.885393662798425 3.2116297961629e-06 -2.42747067684236 2.06814828958882e-10 mirMAP;miRNATAP -0.333191234288059 0.000785967313666436 NA NA NA hsa-miR-29b-3p CCND2 1.65828197923813 1.02676780888141e-09 -2.42747067684236 2.06814828958882e-10 MirTarget;miRNATAP -0.181452610770389 0.00800883535071036 22330340;24130168 In addition to CCND2 miR-29 also targets E2F7 another cell cycle regulator;We further demonstrated that miR-29 family acted as tumor suppressors through targeting CCND2 and matrix metalloproteinase-2 genes in GC ; sarcoma;gastric cancer hsa-miR-301a-3p CCND2 2.81024345929638 2.29784847962242e-17 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate -0.490714440601798 1.13987935585442e-18 NA NA NA hsa-miR-3065-3p CCND2 2.16221780121195 9.65525739884541e-09 -2.42747067684236 2.06814828958882e-10 MirTarget;miRNATAP -0.234083951058536 1.60505150894369e-06 NA NA NA hsa-miR-3065-5p CCND2 2.74629919868982 1.86846589298284e-08 -2.42747067684236 2.06814828958882e-10 mirMAP -0.236930159170796 2.73973057309239e-07 NA NA NA hsa-miR-30d-3p CCND2 0.977747550180601 4.3048212205381e-05 -2.42747067684236 2.06814828958882e-10 mirMAP -0.514799428246913 2.69094766335815e-11 NA NA NA hsa-miR-30e-3p CCND2 -0.215663037684509 0.235375122783546 -2.42747067684236 2.06814828958882e-10 mirMAP -0.317748716556734 0.00256884077064715 NA NA NA hsa-miR-32-3p CCND2 2.02436999565685 5.94091197945307e-09 -2.42747067684236 2.06814828958882e-10 mirMAP -0.37065809204682 5.74913234109809e-10 NA NA NA hsa-miR-320a CCND2 0.438165828017084 0.0390159073347133 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;mirMAP;miRNATAP -0.366959333753783 3.90012764364419e-05 NA NA NA hsa-miR-320b CCND2 1.55692969039548 1.41071034251915e-08 -2.42747067684236 2.06814828958882e-10 mirMAP;miRNATAP -0.389495451202309 5.62361965191887e-09 NA NA NA hsa-miR-324-3p CCND2 2.08739139768981 3.11885987067952e-13 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate -0.569926030100518 1.57078270718816e-20 NA NA NA hsa-miR-331-5p CCND2 2.17414714166315 1.54547681391888e-18 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.55418360999634 4.24751797285043e-14 NA NA NA hsa-miR-335-5p CCND2 1.77247705492746 2.22457658872091e-06 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate -0.196309653133352 7.59470226154717e-05 NA NA NA hsa-miR-33a-3p CCND2 1.72765312072219 1.51784443453521e-07 -2.42747067684236 2.06814828958882e-10 MirTarget -0.474892003832155 3.60158523540778e-15 NA NA NA hsa-miR-3607-3p CCND2 2.68532138541128 5.66716351955047e-14 -2.42747067684236 2.06814828958882e-10 mirMAP -0.253991708738003 1.1264040881505e-06 NA NA NA hsa-miR-374b-3p CCND2 0.930487774873495 2.74420094310516e-05 -2.42747067684236 2.06814828958882e-10 mirMAP -0.379294826109076 7.61411367904561e-06 NA NA NA hsa-miR-378a-3p CCND2 -0.10995720000828 0.716188270032681 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate -0.264766627168263 2.14263562743039e-05 NA NA NA hsa-miR-423-5p CCND2 0.963563145758616 9.86109015204915e-07 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate -0.681308347713645 2.78087673863117e-13 NA NA NA hsa-miR-424-5p CCND2 1.61930224569578 1.89642549274994e-10 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.208747216207423 0.00424259734488207 NA NA NA hsa-miR-429 CCND2 4.48815175680773 2.44117492218206e-17 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.316889169500172 1.77696184266368e-22 NA NA NA hsa-miR-450b-5p CCND2 1.69244418548325 1.68064054148881e-10 -2.42747067684236 2.06814828958882e-10 MirTarget;PITA;miRNATAP -0.299286922863212 1.69011727706147e-05 NA NA NA hsa-miR-500a-5p CCND2 1.72110365584658 3.0807246212659e-10 -2.42747067684236 2.06814828958882e-10 mirMAP -0.230284164405623 0.000679591942778451 NA NA NA hsa-miR-501-5p CCND2 1.93654809410041 1.3779381780759e-10 -2.42747067684236 2.06814828958882e-10 PITA;mirMAP;miRNATAP -0.278516160908165 9.05358509837179e-06 NA NA NA hsa-miR-503-5p CCND2 3.66513190181895 6.60300917645278e-21 -2.42747067684236 2.06814828958882e-10 MirTarget -0.31264390956225 5.2815091282227e-11 25860935 We then identified two targets of miR-503 CCND2 and CCND3 breast cancer hsa-miR-550a-5p CCND2 2.11025227932763 6.94489556637146e-12 -2.42747067684236 2.06814828958882e-10 MirTarget -0.44540662591501 2.41152035101861e-14 NA NA NA hsa-miR-589-3p CCND2 2.51971841868825 2.39125940264107e-11 -2.42747067684236 2.06814828958882e-10 mirMAP -0.360588568041429 3.76015378643146e-11 NA NA NA hsa-miR-590-3p CCND2 2.59289455139753 1.03200520972022e-21 -2.42747067684236 2.06814828958882e-10 miRanda;mirMAP -0.419988530136573 3.79848108645639e-10 NA NA NA hsa-miR-590-5p CCND2 3.18300989862077 2.06813568597893e-26 -2.42747067684236 2.06814828958882e-10 mirMAP -0.50562344923364 6.73026539304424e-18 NA NA NA hsa-miR-660-5p CCND2 1.82692095272076 1.92040083607196e-13 -2.42747067684236 2.06814828958882e-10 mirMAP -0.361636929774302 8.5078492819456e-07 NA NA NA hsa-miR-7-1-3p CCND2 1.84950311431067 1.25300363397654e-13 -2.42747067684236 2.06814828958882e-10 mirMAP -0.518854235917429 5.32697612805784e-13 NA NA NA hsa-miR-708-3p CCND2 2.80907765282502 3.07460722669281e-14 -2.42747067684236 2.06814828958882e-10 mirMAP -0.177604972093223 0.000316375213374722 NA NA NA hsa-miR-708-5p CCND2 3.38051631555486 5.12590198690777e-18 -2.42747067684236 2.06814828958882e-10 mirMAP -0.19367896307831 2.62089031491477e-05 NA NA NA hsa-miR-877-5p CCND2 2.94916202082736 1.8151927276044e-13 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate -0.361363420346396 6.83899428438154e-13 NA NA NA hsa-miR-93-5p CCND2 3.03961860136032 1.11672209617395e-24 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.640135233296746 3.73391346199191e-30 NA NA NA hsa-miR-944 CCND2 2.91186649218281 1.31574753528144e-06 -2.42747067684236 2.06814828958882e-10 PITA;mirMAP -0.168575408637895 9.32931241492905e-08 NA NA NA hsa-miR-96-5p CCND2 4.89433085814374 1.92000659886961e-31 -2.42747067684236 2.06814828958882e-10 TargetScan;miRNATAP -0.382951897231727 7.25785958201884e-21 NA NA NA hsa-miR-27b-3p CCND3 0.196007704287769 0.295630157035388 0.142518749044219 0.397307080616203 miRNAWalker2_validate -0.133645004740845 0.00231237621077374 NA NA NA hsa-miR-186-5p CREBBP 1.47445398888668 3.0781726595413e-15 -0.451040948976341 0.000687386434761364 mirMAP;miRNATAP -0.14581204925591 1.28616268232458e-05 NA NA NA hsa-miR-26b-5p CREBBP 0.885393662798425 3.2116297961629e-06 -0.451040948976341 0.000687386434761364 miRNATAP -0.128164022830949 0.000145104031692185 NA NA NA hsa-miR-186-5p CSNK1A1 1.47445398888668 3.0781726595413e-15 -0.44941384170383 0.000451852597695595 miRNAWalker2_validate;miRNATAP -0.133123000020891 3.70212214593784e-05 NA NA NA hsa-miR-30b-5p CSNK1A1 0.800822374912712 0.000133601914525413 -0.44941384170383 0.000451852597695595 MirTarget;mirMAP;miRNATAP -0.118180154569669 6.21011623572625e-05 NA NA NA hsa-miR-30e-5p CSNK1A1 1.23904909539663 1.35561917122157e-09 -0.44941384170383 0.000451852597695595 MirTarget -0.101664268570004 0.000692966908073001 NA NA NA hsa-miR-450b-5p CSNK1A1 1.69244418548325 1.68064054148881e-10 -0.44941384170383 0.000451852597695595 mirMAP -0.111195472395056 1.04835820980227e-06 NA NA NA hsa-miR-501-3p CSNK1A1 1.83132758513743 1.10971547702065e-10 -0.44941384170383 0.000451852597695595 TargetScan;miRNATAP -0.101660846950203 1.68955245885221e-06 NA NA NA hsa-miR-502-3p CSNK1A1 1.50560877085049 1.2647489756373e-11 -0.44941384170383 0.000451852597695595 miRNATAP -0.140816871532145 2.04570685057883e-07 NA NA NA hsa-miR-542-3p CSNK1A1 1.18832665895751 1.98700670691565e-07 -0.44941384170383 0.000451852597695595 miRanda -0.134211143515693 4.86600766379528e-07 NA NA NA hsa-miR-664a-3p CSNK1A1 0.634721925861133 0.00520070178640421 -0.44941384170383 0.000451852597695595 mirMAP -0.106541910906335 9.54975474973168e-05 NA NA NA hsa-miR-26a-5p CTBP1 0.0464832722967259 0.752628386912329 0.313118768002274 0.00466415731743457 miRNAWalker2_validate -0.109093695613311 0.00325768592780508 NA NA NA hsa-miR-1226-3p CTBP2 1.38118928579963 0.000205503474787488 -0.377807003747428 0.0473156253407303 MirTarget -0.125182502934215 7.41866774444464e-06 NA NA NA hsa-miR-3913-5p CTBP2 2.44353493655328 8.95279496632448e-15 -0.377807003747428 0.0473156253407303 MirTarget -0.140114760581858 1.21594962927193e-06 NA NA NA hsa-miR-28-5p CTNNB1 0.230152919654905 0.0742909586754846 -0.220922161177096 0.11826020711692 miRanda -0.182072912507331 0.000829385072717343 NA NA NA hsa-miR-29c-3p CTNNBIP1 -0.00968972577705429 0.97099586346872 0.637035432123162 7.1682291980654e-06 MirTarget;miRNATAP -0.113745373439536 1.12715059683639e-05 NA NA NA hsa-let-7a-2-3p DAAM1 0.0400317820791161 0.91528727576685 -0.942213696830475 0.00027775597362759 MirTarget -0.102771940931974 0.00252864797691956 NA NA NA hsa-let-7e-5p DAAM1 0.860104282510173 6.04758298373779e-05 -0.942213696830475 0.00027775597362759 miRNAWalker2_validate -0.157641236145075 0.00740060273089441 NA NA NA hsa-let-7g-3p DAAM1 3.26398061402445 3.96263126107645e-25 -0.942213696830475 0.00027775597362759 MirTarget -0.151579495263016 8.54970158134176e-05 NA NA NA hsa-miR-1226-3p DAAM1 1.38118928579963 0.000205503474787488 -0.942213696830475 0.00027775597362759 MirTarget -0.103323546875118 0.0073654885128425 NA NA NA hsa-miR-125a-5p DAAM1 0.599529391575274 0.0102300147180307 -0.942213696830475 0.00027775597362759 MirTarget -0.362868736041077 7.62638741423532e-12 NA NA NA hsa-miR-125b-5p DAAM1 -1.16462950151259 0.000288900271798384 -0.942213696830475 0.00027775597362759 MirTarget;miRNATAP -0.115369546121479 0.00312407328642338 NA NA NA hsa-miR-130a-3p DAAM1 2.02021855058359 1.26427102520415e-11 -0.942213696830475 0.00027775597362759 MirTarget;miRNATAP -0.178368592458766 1.3860676304927e-05 NA NA NA hsa-miR-130b-3p DAAM1 3.5350292994509 1.73934183852569e-27 -0.942213696830475 0.00027775597362759 MirTarget;miRNATAP -0.106111741504673 0.00345145525850313 NA NA NA hsa-miR-130b-5p DAAM1 2.9963110846538 1.98883029416455e-18 -0.942213696830475 0.00027775597362759 MirTarget -0.113327678159746 0.0017765950786503 NA NA NA hsa-miR-140-5p DAAM1 0.844753502512594 3.73722278438606e-05 -0.942213696830475 0.00027775597362759 miRanda -0.304699334450491 5.89677534024278e-07 NA NA NA hsa-miR-142-3p DAAM1 2.75247908790621 1.45636065474764e-12 -0.942213696830475 0.00027775597362759 miRanda -0.109145560639661 0.000519811746698834 NA NA NA hsa-miR-181a-5p DAAM1 2.29556023480783 1.8138457900616e-21 -0.942213696830475 0.00027775597362759 mirMAP -0.322824758326189 4.08278167042441e-11 NA NA NA hsa-miR-181b-5p DAAM1 2.49307679431293 3.92829250217627e-20 -0.942213696830475 0.00027775597362759 mirMAP -0.197346738755335 7.87932551440467e-06 NA NA NA hsa-miR-181c-5p DAAM1 1.58587920618301 1.57506918816933e-10 -0.942213696830475 0.00027775597362759 mirMAP -0.27256160695568 3.30224262613358e-08 NA NA NA hsa-miR-186-5p DAAM1 1.47445398888668 3.0781726595413e-15 -0.942213696830475 0.00027775597362759 MirTarget;mirMAP -0.368925277090905 1.38277768429258e-08 NA NA NA hsa-miR-194-5p DAAM1 1.8992998339217 3.76507853301977e-10 -0.942213696830475 0.00027775597362759 miRNATAP -0.205815550659589 3.38369729014767e-07 NA NA NA hsa-miR-19a-3p DAAM1 3.42309334186656 3.02671914353412e-28 -0.942213696830475 0.00027775597362759 miRNATAP -0.209221721983658 2.33485016798375e-08 NA NA NA hsa-miR-19b-3p DAAM1 2.49529833021187 1.57028265846699e-23 -0.942213696830475 0.00027775597362759 miRNATAP -0.247649922926255 1.78362791297128e-07 NA NA NA hsa-miR-21-5p DAAM1 2.73773305747971 1.38864982139576e-43 -0.942213696830475 0.00027775597362759 miRNAWalker2_validate -0.299047327222438 1.66181520629082e-07 NA NA NA hsa-miR-218-5p DAAM1 -0.573801507392184 0.0551983860126703 -0.942213696830475 0.00027775597362759 MirTarget;miRNATAP -0.208397633638745 6.10149755724725e-07 NA NA NA hsa-miR-29b-3p DAAM1 1.65828197923813 1.02676780888141e-09 -0.942213696830475 0.00027775597362759 MirTarget;miRNATAP -0.345351912509756 6.04658193265482e-15 NA NA NA hsa-miR-29c-3p DAAM1 -0.00968972577705429 0.97099586346872 -0.942213696830475 0.00027775597362759 MirTarget;miRNATAP -0.165589566861911 0.00048429450796675 NA NA NA hsa-miR-301a-3p DAAM1 2.81024345929638 2.29784847962242e-17 -0.942213696830475 0.00027775597362759 MirTarget;miRNATAP -0.14585640705549 0.000153623423061836 NA NA NA hsa-miR-32-5p DAAM1 2.34056473219422 6.24134585974322e-20 -0.942213696830475 0.00027775597362759 miRNATAP -0.169210661803019 0.000322502829632488 NA NA NA hsa-miR-320a DAAM1 0.438165828017084 0.0390159073347133 -0.942213696830475 0.00027775597362759 miRanda -0.193145033698115 0.0012332777633916 NA NA NA hsa-miR-34a-5p DAAM1 1.9016323452565 1.43092834643601e-14 -0.942213696830475 0.00027775597362759 MirTarget;miRNATAP -0.314744989230111 9.66343935466443e-11 NA NA NA hsa-miR-362-3p DAAM1 2.0756816987665 3.89026064579331e-12 -0.942213696830475 0.00027775597362759 MirTarget;miRanda;miRNATAP -0.178350047588923 2.47227365820513e-05 NA NA NA hsa-miR-454-3p DAAM1 2.47234127820054 1.12878018736016e-21 -0.942213696830475 0.00027775597362759 MirTarget;miRNATAP -0.290867714924666 5.91657257033642e-10 NA NA NA hsa-miR-500a-3p DAAM1 1.47161373123699 5.30571342631915e-09 -0.942213696830475 0.00027775597362759 MirTarget -0.250296993686989 2.92622882548095e-07 NA NA NA hsa-miR-576-5p DAAM1 2.20467023993664 3.4053475193793e-19 -0.942213696830475 0.00027775597362759 mirMAP -0.269788006673554 2.74339444820014e-08 NA NA NA hsa-miR-590-3p DAAM1 2.59289455139753 1.03200520972022e-21 -0.942213696830475 0.00027775597362759 MirTarget;miRanda;mirMAP -0.149867592047944 0.00099368469636386 NA NA NA hsa-miR-92a-3p DAAM1 2.06460102658973 1.44784291084757e-19 -0.942213696830475 0.00027775597362759 miRNATAP -0.181869877738483 0.000601016959572564 NA NA NA hsa-miR-141-5p DAAM2 3.81419396518882 3.21977359736126e-18 -2.22700754971104 2.14986647076169e-10 mirMAP -0.380875705787807 1.11753905137362e-26 NA NA NA hsa-miR-144-5p DAAM2 0.195856574290527 0.61856475838049 -2.22700754971104 2.14986647076169e-10 mirMAP -0.154970482803939 0.000429284573722913 NA NA NA hsa-miR-182-5p DAAM2 3.53923166221814 5.07781258121574e-21 -2.22700754971104 2.14986647076169e-10 mirMAP -0.375542841324343 4.32635099356557e-19 NA NA NA hsa-miR-18a-5p DAAM2 3.78535678765353 3.72446596213886e-26 -2.22700754971104 2.14986647076169e-10 miRNAWalker2_validate -0.334705695374522 1.00225123053855e-12 NA NA NA hsa-miR-1976 DAAM2 2.06550563678192 7.81396978619772e-18 -2.22700754971104 2.14986647076169e-10 mirMAP -0.635241050457801 1.06336591472668e-21 NA NA NA hsa-miR-19b-3p DAAM2 2.49529833021187 1.57028265846699e-23 -2.22700754971104 2.14986647076169e-10 miRNAWalker2_validate -0.603285529228415 7.99036004572353e-22 NA NA NA hsa-miR-205-5p DAAM2 4.1389800495524 2.05488295686453e-12 -2.22700754971104 2.14986647076169e-10 mirMAP -0.31809708429492 2.29594126518672e-33 NA NA NA hsa-miR-335-5p DAAM2 1.77247705492746 2.22457658872091e-06 -2.22700754971104 2.14986647076169e-10 mirMAP -0.175264202896827 0.000120234134632896 NA NA NA hsa-miR-339-5p DAAM2 2.68710938429893 3.03134080808154e-16 -2.22700754971104 2.14986647076169e-10 miRanda -0.347838572362897 2.46899789836209e-12 NA NA NA hsa-miR-34c-5p DAAM2 2.07190852984647 7.35776320806257e-08 -2.22700754971104 2.14986647076169e-10 miRanda -0.197045279867164 2.85466789211435e-05 NA NA NA hsa-miR-361-3p DAAM2 1.07367425434318 1.73142774168958e-09 -2.22700754971104 2.14986647076169e-10 mirMAP -0.606835022253672 1.57886551868404e-10 NA NA NA hsa-miR-421 DAAM2 1.17791565395543 6.78526676976629e-06 -2.22700754971104 2.14986647076169e-10 PITA;miRanda -0.276036549390652 2.60625908783666e-05 NA NA NA hsa-miR-429 DAAM2 4.48815175680773 2.44117492218206e-17 -2.22700754971104 2.14986647076169e-10 miRNATAP -0.264111278386911 1.92912110561275e-18 NA NA NA hsa-miR-589-3p DAAM2 2.51971841868825 2.39125940264107e-11 -2.22700754971104 2.14986647076169e-10 mirMAP -0.299821068340841 2.51656739765832e-09 NA NA NA hsa-miR-590-3p DAAM2 2.59289455139753 1.03200520972022e-21 -2.22700754971104 2.14986647076169e-10 miRanda;mirMAP -0.543327785529025 1.51598725119254e-19 NA NA NA hsa-miR-592 DAAM2 1.51765968871077 0.000636335248013204 -2.22700754971104 2.14986647076169e-10 mirMAP -0.104593314331342 0.00821097186445116 NA NA NA hsa-miR-324-5p DKK2 2.95683728155095 1.32960514360912e-20 1.44564448604015 0.00747875982641354 miRanda -0.27403390711194 0.000484282397326861 NA NA NA hsa-miR-33a-3p DKK2 1.72765312072219 1.51784443453521e-07 1.44564448604015 0.00747875982641354 mirMAP -0.333670025356465 0.0001069453896843 NA NA NA hsa-miR-3607-3p DKK2 2.68532138541128 5.66716351955047e-14 1.44564448604015 0.00747875982641354 miRNATAP -0.254621362344641 0.000480577902616865 NA NA NA hsa-miR-361-5p DKK2 0.971859117235239 5.30236555707088e-09 1.44564448604015 0.00747875982641354 miRanda -0.529805018231185 0.000736067537533342 NA NA NA hsa-miR-486-5p DKK2 -0.194913133034028 0.607377798807705 1.44564448604015 0.00747875982641354 miRanda;miRNATAP -0.316330846053953 4.09529683167035e-06 NA NA NA hsa-miR-576-5p DKK2 2.20467023993664 3.4053475193793e-19 1.44564448604015 0.00747875982641354 mirMAP -0.269909098631812 0.00840039279002918 NA NA NA hsa-miR-664a-3p DKK2 0.634721925861133 0.00520070178640421 1.44564448604015 0.00747875982641354 mirMAP -0.454400313588311 8.24508477503484e-05 NA NA NA hsa-miR-944 DKK2 2.91186649218281 1.31574753528144e-06 1.44564448604015 0.00747875982641354 mirMAP -0.175659848685514 6.96107424887464e-05 NA NA NA hsa-miR-30a-3p DVL3 -2.08290159592947 3.95783261640728e-14 0.412235294167264 0.000274823815979202 MirTarget -0.106440185561165 2.42872660854649e-08 NA NA NA hsa-miR-140-5p EP300 0.844753502512594 3.73722278438606e-05 -0.259813561364416 0.130645976324069 miRNAWalker2_validate -0.116180580124631 0.0041461159891489 NA NA NA hsa-miR-142-5p EP300 1.17581605694506 0.0018174701991234 -0.259813561364416 0.130645976324069 PITA;mirMAP;miRNATAP -0.111374437902145 2.72973348003874e-07 23342264 In contrast to the mouse p300 gene the human p300 gene was not found to be a target for miR-142-5p B cell lymphoma hsa-miR-193b-3p EP300 2.25711804611899 4.1940744806631e-14 -0.259813561364416 0.130645976324069 miRNAWalker2_validate -0.105745678811168 8.10977033783005e-05 NA NA NA hsa-miR-22-3p EP300 1.21545661147757 1.61670170137775e-13 -0.259813561364416 0.130645976324069 MirTarget;miRNATAP -0.202351996320887 4.21898434047145e-05 NA NA NA hsa-miR-29b-1-5p EP300 1.55384379072167 4.76870585070176e-05 -0.259813561364416 0.130645976324069 MirTarget -0.128437592094259 1.17066262616741e-08 NA NA NA hsa-miR-342-3p EP300 1.49115144672245 1.43879249744621e-07 -0.259813561364416 0.130645976324069 MirTarget;PITA;miRanda;miRNATAP -0.216290263558714 1.26951899192842e-14 NA NA NA hsa-miR-361-3p EP300 1.07367425434318 1.73142774168958e-09 -0.259813561364416 0.130645976324069 PITA -0.267683295831071 4.11859386761575e-09 NA NA NA hsa-miR-101-3p FBXW11 0.522819989585461 0.00375627731618038 -0.6053355793347 2.43759511622661e-07 MirTarget;miRNATAP -0.1068970532894 0.000831195472548073 NA NA NA hsa-miR-106b-5p FBXW11 2.46782146831112 1.36171495805632e-23 -0.6053355793347 2.43759511622661e-07 miRNATAP -0.133871111185436 6.31270412587771e-10 NA NA NA hsa-miR-148b-3p FBXW11 1.97815018171325 6.07715327281595e-26 -0.6053355793347 2.43759511622661e-07 miRNAWalker2_validate -0.14597497675447 3.43285563860754e-07 NA NA NA hsa-miR-16-5p FBXW11 1.75824877145857 1.68592440033108e-16 -0.6053355793347 2.43759511622661e-07 miRNAWalker2_validate -0.10499399238876 5.03647247156714e-05 NA NA NA hsa-miR-186-5p FBXW11 1.47445398888668 3.0781726595413e-15 -0.6053355793347 2.43759511622661e-07 mirMAP -0.166462193668095 1.66771830021087e-08 NA NA NA hsa-miR-19a-3p FBXW11 3.42309334186656 3.02671914353412e-28 -0.6053355793347 2.43759511622661e-07 MirTarget -0.108311755991211 1.45419218352444e-10 NA NA NA hsa-miR-19b-3p FBXW11 2.49529833021187 1.57028265846699e-23 -0.6053355793347 2.43759511622661e-07 MirTarget -0.127282346966739 2.81248393053129e-09 NA NA NA hsa-miR-301a-3p FBXW11 2.81024345929638 2.29784847962242e-17 -0.6053355793347 2.43759511622661e-07 MirTarget -0.102606306404108 2.81626252880213e-09 NA NA NA hsa-miR-330-3p FBXW11 0.876747334239085 0.00073709016089703 -0.6053355793347 2.43759511622661e-07 MirTarget;PITA;miRNATAP -0.10307956762463 2.31244947474721e-06 NA NA NA hsa-miR-374a-5p FBXW11 0.484615721953736 0.0042981729815149 -0.6053355793347 2.43759511622661e-07 mirMAP -0.135168340854082 7.00122336685201e-05 NA NA NA hsa-miR-450a-5p FBXW11 2.00113616793868 5.25910974095652e-13 -0.6053355793347 2.43759511622661e-07 miRNAWalker2_validate -0.106863968686943 1.69934387008649e-07 NA NA NA hsa-miR-454-3p FBXW11 2.47234127820054 1.12878018736016e-21 -0.6053355793347 2.43759511622661e-07 MirTarget -0.138327954771508 7.69148432838817e-11 NA NA NA hsa-miR-93-5p FBXW11 3.03961860136032 1.11672209617395e-24 -0.6053355793347 2.43759511622661e-07 miRNATAP -0.110444879718319 7.00982042662947e-10 NA NA NA hsa-miR-429 FOSL1 4.48815175680773 2.44117492218206e-17 -1.55097223915852 0.000233777363972793 miRanda;miRNATAP -0.174959716036854 2.01689973360073e-06 NA NA NA hsa-miR-125b-5p FRAT2 -1.16462950151259 0.000288900271798384 0.834462572829603 4.59724637790472e-06 miRNAWalker2_validate;miRNATAP -0.140444783791666 2.49621560322905e-07 NA NA NA hsa-miR-29a-3p FRAT2 -0.35074463683376 0.161238718982428 0.834462572829603 4.59724637790472e-06 miRNATAP -0.183868576313386 1.88874572210214e-07 NA NA NA hsa-miR-148b-5p FZD1 2.18024067300781 2.84770452413262e-14 -0.425436558189808 0.0799738924745079 MirTarget -0.185337464920658 9.26075370601374e-06 NA NA NA hsa-miR-186-5p FZD1 1.47445398888668 3.0781726595413e-15 -0.425436558189808 0.0799738924745079 mirMAP -0.256651764559262 2.6511156970226e-05 NA NA NA hsa-miR-192-5p FZD1 2.69002528723195 1.22990188194432e-16 -0.425436558189808 0.0799738924745079 miRNAWalker2_validate -0.155057877498576 7.39037537532272e-06 NA NA NA hsa-miR-200a-5p FZD1 3.86316681673704 1.81076942093171e-15 -0.425436558189808 0.0799738924745079 MirTarget -0.113568422277534 8.68868038604123e-07 NA NA NA hsa-miR-200b-5p FZD1 2.54484902707822 1.59240467582976e-06 -0.425436558189808 0.0799738924745079 MirTarget -0.117574059809566 1.53611179067253e-06 NA NA NA hsa-miR-29b-3p FZD1 1.65828197923813 1.02676780888141e-09 -0.425436558189808 0.0799738924745079 mirMAP -0.262792829355677 3.08641120731195e-10 NA NA NA hsa-miR-29c-3p FZD1 -0.00968972577705429 0.97099586346872 -0.425436558189808 0.0799738924745079 mirMAP -0.235860731130814 7.14943079977686e-08 NA NA NA hsa-miR-590-3p FZD1 2.59289455139753 1.03200520972022e-21 -0.425436558189808 0.0799738924745079 miRanda -0.161949528189327 0.000129709540916742 NA NA NA hsa-miR-93-3p FZD1 2.85383869771942 5.64481766902125e-23 -0.425436558189808 0.0799738924745079 MirTarget -0.154987566584066 5.3611154116737e-05 NA NA NA hsa-miR-92b-3p FZD10 1.20409245530001 3.41055816361655e-06 -1.28150312911457 0.0222651851945126 miRNATAP -0.321084810294164 0.00202154343824695 NA NA NA hsa-let-7c-5p FZD3 -2.07847142524506 5.51224567263294e-09 -0.309421802986829 0.225620520315636 MirTarget -0.112394995313295 0.000923332007879197 NA NA NA hsa-let-7f-1-3p FZD3 1.55054488387679 7.31326775537952e-11 -0.309421802986829 0.225620520315636 MirTarget -0.184443397656298 0.000418481859781762 NA NA NA hsa-let-7i-5p FZD3 0.412877696970403 0.00622731051981756 -0.309421802986829 0.225620520315636 MirTarget;miRNATAP -0.399590260605759 1.3000716715047e-06 NA NA NA hsa-miR-140-5p FZD3 0.844753502512594 3.73722278438606e-05 -0.309421802986829 0.225620520315636 miRanda -0.188169794963344 0.00178065542348547 NA NA NA hsa-miR-142-3p FZD3 2.75247908790621 1.45636065474764e-12 -0.309421802986829 0.225620520315636 miRanda -0.169360517606185 2.61245265836168e-08 NA NA NA hsa-miR-145-5p FZD3 -1.55259331973517 9.97889123247165e-07 -0.309421802986829 0.225620520315636 mirMAP -0.114187387512836 0.00296030669990046 NA NA NA hsa-miR-146a-5p FZD3 1.19829319599115 0.00157081974524452 -0.309421802986829 0.225620520315636 MirTarget -0.158517509875284 7.77007948973314e-07 NA NA NA hsa-miR-146b-5p FZD3 1.75587235896724 1.15724631266659e-07 -0.309421802986829 0.225620520315636 MirTarget;miRanda -0.248619517368953 4.16178646137606e-12 NA NA NA hsa-miR-155-5p FZD3 1.20164021433135 0.00086170622431261 -0.309421802986829 0.225620520315636 mirMAP -0.223394374054016 1.99686402180728e-11 NA NA NA hsa-miR-16-2-3p FZD3 2.31623086727196 4.29838149388188e-20 -0.309421802986829 0.225620520315636 mirMAP -0.142741019197219 0.00229392409437174 NA NA NA hsa-miR-27a-3p FZD3 1.66542180327138 4.93775737894805e-13 -0.309421802986829 0.225620520315636 miRNATAP -0.19890982925031 0.000136253026426204 NA NA NA hsa-miR-29a-5p FZD3 1.46749674755271 3.34605004270294e-07 -0.309421802986829 0.225620520315636 mirMAP -0.227560485383059 2.97812930925699e-07 NA NA NA hsa-miR-30a-5p FZD3 -0.878357906436456 0.000509952992366057 -0.309421802986829 0.225620520315636 MirTarget;miRNATAP -0.187269850482729 0.000115755030201797 NA NA NA hsa-miR-338-3p FZD3 0.453166438193782 0.144583389707558 -0.309421802986829 0.225620520315636 PITA;miRanda -0.130140350228584 0.00105449606790809 NA NA NA hsa-miR-342-3p FZD3 1.49115144672245 1.43879249744621e-07 -0.309421802986829 0.225620520315636 miRanda -0.175491195046215 4.09956006364612e-05 NA NA NA hsa-miR-655-3p FZD3 0.485339318272148 0.137014658258732 -0.309421802986829 0.225620520315636 MirTarget -0.102336176080738 0.00792280380264869 NA NA NA hsa-let-7a-3p FZD4 1.42015538786275 7.03375209382654e-13 -0.82842258037894 0.00067769989049317 mirMAP -0.25978692105295 8.60947548901181e-06 NA NA NA hsa-let-7a-5p FZD4 0.618599506841644 2.76973453058748e-05 -0.82842258037894 0.00067769989049317 MirTarget;TargetScan;miRNATAP -0.253176019619405 0.00185266409499946 NA NA NA hsa-let-7b-3p FZD4 0.868207752019623 1.30460056774366e-05 -0.82842258037894 0.00067769989049317 mirMAP -0.288752028096756 9.73911194534638e-07 NA NA NA hsa-let-7b-5p FZD4 0.604314269683977 0.00140009936153214 -0.82842258037894 0.00067769989049317 MirTarget;miRNATAP -0.22284658021311 0.000398841305697788 NA NA NA hsa-let-7d-5p FZD4 1.33236798905207 1.1741085658466e-13 -0.82842258037894 0.00067769989049317 MirTarget;miRNATAP -0.265842261869076 3.75959518026377e-05 NA NA NA hsa-let-7f-1-3p FZD4 1.55054488387679 7.31326775537952e-11 -0.82842258037894 0.00067769989049317 mirMAP -0.283833517350996 1.05011620508551e-08 NA NA NA hsa-let-7g-3p FZD4 3.26398061402445 3.96263126107645e-25 -0.82842258037894 0.00067769989049317 MirTarget;miRNATAP -0.156205833669187 1.57695987305832e-05 NA NA NA hsa-miR-106b-5p FZD4 2.46782146831112 1.36171495805632e-23 -0.82842258037894 0.00067769989049317 miRNATAP -0.234613445833142 2.00902874110226e-07 NA NA NA hsa-miR-130b-3p FZD4 3.5350292994509 1.73934183852569e-27 -0.82842258037894 0.00067769989049317 mirMAP -0.13908667691121 4.12501037456859e-05 NA NA NA hsa-miR-141-3p FZD4 5.02396127982626 2.19224509139725e-24 -0.82842258037894 0.00067769989049317 TargetScan -0.113168852885507 4.32145832906429e-07 NA NA NA hsa-miR-15b-5p FZD4 1.57112623124278 9.14247846750597e-13 -0.82842258037894 0.00067769989049317 MirTarget -0.222207258760378 2.25967536549653e-05 NA NA NA hsa-miR-16-5p FZD4 1.75824877145857 1.68592440033108e-16 -0.82842258037894 0.00067769989049317 MirTarget -0.159732157502559 0.00302538129317839 NA NA NA hsa-miR-17-3p FZD4 2.2704817679209 1.1667437320211e-22 -0.82842258037894 0.00067769989049317 MirTarget -0.255826576295246 1.07111820305919e-07 NA NA NA hsa-miR-17-5p FZD4 3.2710598467455 9.93128340539455e-27 -0.82842258037894 0.00067769989049317 TargetScan -0.1860118666133 2.38183720623219e-07 NA NA NA hsa-miR-185-5p FZD4 2.34016206907488 1.17481626642022e-26 -0.82842258037894 0.00067769989049317 MirTarget -0.1624728760308 0.00145151073626332 NA NA NA hsa-miR-186-5p FZD4 1.47445398888668 3.0781726595413e-15 -0.82842258037894 0.00067769989049317 mirMAP -0.205145494132056 0.000907015467370243 NA NA NA hsa-miR-200c-3p FZD4 3.50132673580082 2.42716349086937e-15 -0.82842258037894 0.00067769989049317 mirMAP -0.112009526076228 1.27368925786649e-05 NA NA NA hsa-miR-20a-5p FZD4 3.15577933619191 4.19753346442454e-25 -0.82842258037894 0.00067769989049317 miRNATAP -0.166704290095965 4.54648957073464e-06 NA NA NA hsa-miR-21-5p FZD4 2.73773305747971 1.38864982139576e-43 -0.82842258037894 0.00067769989049317 mirMAP -0.239429729133893 8.97376444314049e-06 NA NA NA hsa-miR-24-3p FZD4 0.99989036772428 1.35595013650376e-07 -0.82842258037894 0.00067769989049317 miRNAWalker2_validate -0.359185041809163 4.66677691729471e-09 NA NA NA hsa-miR-25-3p FZD4 1.36472605225697 4.83790725935681e-11 -0.82842258037894 0.00067769989049317 mirMAP -0.19772322105664 0.000423841571889771 NA NA NA hsa-miR-27a-3p FZD4 1.66542180327138 4.93775737894805e-13 -0.82842258037894 0.00067769989049317 miRNATAP -0.292284213552613 3.45359392648561e-09 NA NA NA hsa-miR-27b-3p FZD4 0.196007704287769 0.295630157035388 -0.82842258037894 0.00067769989049317 miRNATAP -0.181363436048367 0.0046411443483725 NA NA NA hsa-miR-301a-3p FZD4 2.81024345929638 2.29784847962242e-17 -0.82842258037894 0.00067769989049317 mirMAP -0.117677900903377 0.00118038399178935 NA NA NA hsa-miR-3065-3p FZD4 2.16221780121195 9.65525739884541e-09 -0.82842258037894 0.00067769989049317 mirMAP -0.113524251684655 0.000224130806075724 NA NA NA hsa-miR-3065-5p FZD4 2.74629919868982 1.86846589298284e-08 -0.82842258037894 0.00067769989049317 mirMAP -0.119046399522189 4.20752397742188e-05 NA NA NA hsa-miR-32-3p FZD4 2.02436999565685 5.94091197945307e-09 -0.82842258037894 0.00067769989049317 mirMAP -0.121313188515894 0.00146602910261851 NA NA NA hsa-miR-32-5p FZD4 2.34056473219422 6.24134585974322e-20 -0.82842258037894 0.00067769989049317 mirMAP -0.203096878419163 3.87447920056755e-06 NA NA NA hsa-miR-324-3p FZD4 2.08739139768981 3.11885987067952e-13 -0.82842258037894 0.00067769989049317 miRNATAP -0.113264342841433 0.00491634431774974 NA NA NA hsa-miR-361-5p FZD4 0.971859117235239 5.30236555707088e-09 -0.82842258037894 0.00067769989049317 mirMAP -0.191172612241245 0.00713666078545409 NA NA NA hsa-miR-454-3p FZD4 2.47234127820054 1.12878018736016e-21 -0.82842258037894 0.00067769989049317 mirMAP -0.139970768625635 0.00181253009277159 NA NA NA hsa-miR-455-3p FZD4 3.06093594997644 3.54590649799868e-16 -0.82842258037894 0.00067769989049317 mirMAP -0.230319605456065 5.42542580292919e-15 NA NA NA hsa-miR-484 FZD4 1.81844463411787 1.82951571230938e-15 -0.82842258037894 0.00067769989049317 PITA -0.146355568993551 0.00363156555895962 NA NA NA hsa-miR-576-5p FZD4 2.20467023993664 3.4053475193793e-19 -0.82842258037894 0.00067769989049317 mirMAP -0.155015734273566 0.00077934632251741 NA NA NA hsa-miR-589-3p FZD4 2.51971841868825 2.39125940264107e-11 -0.82842258037894 0.00067769989049317 mirMAP -0.101476590178804 0.00364724192420982 NA NA NA hsa-miR-590-3p FZD4 2.59289455139753 1.03200520972022e-21 -0.82842258037894 0.00067769989049317 miRanda;mirMAP;miRNATAP -0.205499414009594 1.28884464268856e-06 NA NA NA hsa-miR-590-5p FZD4 3.18300989862077 2.06813568597893e-26 -0.82842258037894 0.00067769989049317 mirMAP -0.16093337799438 2.2971486034504e-05 NA NA NA hsa-miR-629-3p FZD4 2.36570947321815 1.33458201201618e-11 -0.82842258037894 0.00067769989049317 miRNATAP -0.173241875105555 3.00908592587117e-06 NA NA NA hsa-miR-7-1-3p FZD4 1.84950311431067 1.25300363397654e-13 -0.82842258037894 0.00067769989049317 mirMAP -0.289387180518199 1.81200956234101e-10 NA NA NA hsa-miR-708-5p FZD4 3.38051631555486 5.12590198690777e-18 -0.82842258037894 0.00067769989049317 miRNATAP -0.126330673307189 1.20305402790233e-05 NA NA NA hsa-miR-92a-3p FZD4 2.06460102658973 1.44784291084757e-19 -0.82842258037894 0.00067769989049317 mirMAP -0.276111924541506 2.02594943913648e-08 NA NA NA hsa-miR-92b-3p FZD4 1.20409245530001 3.41055816361655e-06 -0.82842258037894 0.00067769989049317 mirMAP -0.174194495695691 0.000116092372079185 NA NA NA hsa-miR-100-5p FZD5 -1.48442967087177 1.5610956769298e-05 0.915137361219814 0.000223509460129262 MirTarget;miRNATAP -0.138861957208489 6.08025549765444e-05 NA NA NA hsa-miR-139-5p FZD6 -1.52606598644743 1.20474151350665e-08 0.392854306882718 0.0923152139379722 miRanda -0.185158723711081 7.18808904187687e-06 NA NA NA hsa-miR-199a-5p FZD6 0.592984035153911 0.0674836634175293 0.392854306882718 0.0923152139379722 MirTarget;miRanda;miRNATAP -0.124790773147726 0.000323934870815636 25772759 FZD6 expression is negatively regulated by miR 199a 5p in human colorectal cancer; These results suggest that overexpression of FZD6 mediated by reduced expression of miR-199a-5p may play an important role in the development of CRC colorectal cancer hsa-miR-106b-5p FZD7 2.46782146831112 1.36171495805632e-23 -2.07792245991139 2.14296526511864e-14 miRNATAP -0.339574506280624 3.43686586684063e-11 NA NA NA hsa-miR-130b-5p FZD7 2.9963110846538 1.98883029416455e-18 -2.07792245991139 2.14296526511864e-14 mirMAP -0.206728540438605 8.73355100311931e-08 NA NA NA hsa-miR-142-3p FZD7 2.75247908790621 1.45636065474764e-12 -2.07792245991139 2.14296526511864e-14 miRanda -0.152811454409089 5.81592039338386e-06 25976503 MicroRNA 142 3p inhibits cell proliferation and invasion of cervical cancer cells by targeting FZD7; In addition we demonstrated that FZD7 was a direct target of miR-142-3p by dual luciferase assay and Western blot analysis; Overexpression of FZD7 expression was able to reverse the inhibitory effects induced by miR-142-3p cervical and endocervical cancer hsa-miR-186-5p FZD7 1.47445398888668 3.0781726595413e-15 -2.07792245991139 2.14296526511864e-14 mirMAP -0.421660397889243 1.57443547405505e-09 NA NA NA hsa-miR-192-5p FZD7 2.69002528723195 1.22990188194432e-16 -2.07792245991139 2.14296526511864e-14 miRNAWalker2_validate -0.260277559911997 4.18887516142845e-11 NA NA NA hsa-miR-20a-5p FZD7 3.15577933619191 4.19753346442454e-25 -2.07792245991139 2.14296526511864e-14 miRNATAP -0.279471256463213 1.0295927958098e-11 NA NA NA hsa-miR-215-5p FZD7 2.30755467422978 2.38476032118039e-06 -2.07792245991139 2.14296526511864e-14 miRNAWalker2_validate -0.147125197323382 1.3786520227744e-07 NA NA NA hsa-miR-27a-3p FZD7 1.66542180327138 4.93775737894805e-13 -2.07792245991139 2.14296526511864e-14 MirTarget;miRNATAP -0.277575918923312 1.16882224241177e-06 24018051 Moreover up-regulation of miR-27a did not decrease the FZD7 mRNA level but significantly reduce its protein expression in BEL/5-FU cells; It was also confirmed that reduction of FZD7 by RNA interference induced inhibitory effects on the expression of MDR1/P-glycoprotein and β-catenin similar to miR-27a liver cancer hsa-miR-3065-5p FZD7 2.74629919868982 1.86846589298284e-08 -2.07792245991139 2.14296526511864e-14 MirTarget;miRNATAP -0.116253203875887 0.000504667102805114 NA NA NA hsa-miR-330-3p FZD7 0.876747334239085 0.00073709016089703 -2.07792245991139 2.14296526511864e-14 mirMAP -0.208278834363313 6.1985483100947e-05 NA NA NA hsa-miR-335-3p FZD7 3.08791651139852 5.31309869723517e-12 -2.07792245991139 2.14296526511864e-14 mirMAP -0.110301729451537 0.000176139270239384 NA NA NA hsa-miR-33a-3p FZD7 1.72765312072219 1.51784443453521e-07 -2.07792245991139 2.14296526511864e-14 mirMAP;miRNATAP -0.190495098959605 1.87779599885811e-05 NA NA NA hsa-miR-429 FZD7 4.48815175680773 2.44117492218206e-17 -2.07792245991139 2.14296526511864e-14 miRanda;miRNATAP -0.141505473835618 4.98870806283658e-09 NA NA NA hsa-miR-532-5p FZD7 1.55697650978597 1.57884735535196e-11 -2.07792245991139 2.14296526511864e-14 PITA;miRNATAP -0.263789010664099 4.11126202273311e-06 NA NA NA hsa-miR-590-3p FZD7 2.59289455139753 1.03200520972022e-21 -2.07792245991139 2.14296526511864e-14 miRanda -0.352411608450585 1.67919803776145e-13 NA NA NA hsa-miR-940 FZD7 3.21011374578759 2.7923171128495e-14 -2.07792245991139 2.14296526511864e-14 miRNAWalker2_validate -0.171852955105736 3.30424707745803e-07 NA NA NA hsa-miR-324-5p FZD8 2.95683728155095 1.32960514360912e-20 -0.823815646444258 0.00951023084929651 miRanda -0.279779712433669 7.35608925341817e-10 NA NA NA hsa-miR-429 FZD8 4.48815175680773 2.44117492218206e-17 -0.823815646444258 0.00951023084929651 miRanda -0.179347702117017 5.02703658451684e-11 NA NA NA hsa-miR-491-5p FZD8 0.615770352820862 0.0418295628761654 -0.823815646444258 0.00951023084929651 miRanda -0.185509761219535 0.000672381095466849 NA NA NA hsa-miR-590-3p FZD8 2.59289455139753 1.03200520972022e-21 -0.823815646444258 0.00951023084929651 miRanda -0.299591132423302 5.09896542046123e-08 NA NA NA hsa-miR-7-1-3p FZD8 1.84950311431067 1.25300363397654e-13 -0.823815646444258 0.00951023084929651 MirTarget -0.247871957087296 3.43262854275173e-05 NA NA NA hsa-miR-99b-5p FZD8 0.814286288944185 0.000299800699512742 -0.823815646444258 0.00951023084929651 MirTarget -0.211256090995937 0.00201196100333719 NA NA NA hsa-miR-139-5p GSK3B -1.52606598644743 1.20474151350665e-08 0.406268283461383 0.000508906658360755 mirMAP -0.100160771461377 1.20519675407331e-06 NA NA NA hsa-miR-101-3p JUN 0.522819989585461 0.00375627731618038 -2.04611084807692 9.1524625995215e-13 miRNAWalker2_validate -0.362533052186516 4.72957409908478e-06 NA NA NA hsa-miR-141-3p JUN 5.02396127982626 2.19224509139725e-24 -2.04611084807692 9.1524625995215e-13 miRNATAP -0.202238939720509 1.9524950223322e-14 NA NA NA hsa-miR-149-5p JUN 2.94200492826326 4.93436498919036e-14 -2.04611084807692 9.1524625995215e-13 miRNAWalker2_validate;miRNATAP -0.155172431476894 9.83577829040368e-06 NA NA NA hsa-miR-15a-5p JUN 2.34669284378787 1.69544424500258e-23 -2.04611084807692 9.1524625995215e-13 miRNAWalker2_validate -0.322829003344663 1.37042285263916e-08 NA NA NA hsa-miR-16-5p JUN 1.75824877145857 1.68592440033108e-16 -2.04611084807692 9.1524625995215e-13 miRNAWalker2_validate -0.384340701644607 1.66878593693069e-09 NA NA NA hsa-miR-200a-3p JUN 4.59434485520731 6.38952518573476e-18 -2.04611084807692 9.1524625995215e-13 miRNATAP -0.185345884656907 9.93412020536435e-14 NA NA NA hsa-miR-200b-3p JUN 3.78235093249346 3.18343003239465e-14 -2.04611084807692 9.1524625995215e-13 MirTarget;TargetScan -0.190113959616059 1.82414115729818e-12 NA NA NA hsa-miR-200c-3p JUN 3.50132673580082 2.42716349086937e-15 -2.04611084807692 9.1524625995215e-13 MirTarget -0.195019704023245 1.57363395803084e-10 NA NA NA hsa-miR-26b-5p JUN 0.885393662798425 3.2116297961629e-06 -2.04611084807692 9.1524625995215e-13 miRNAWalker2_validate -0.246116506815496 0.00101325681187835 21901137;27078844 When c-Jun N-terminal kinase activity was inhibited using SP600125 expression of miR-26b was induced following γ-irradiation in H1299 cells;MicroRNA 26b inhibits tumor metastasis by targeting the KPNA2/c jun pathway in human gastric cancer ;metastasis lung cancer;gastric cancer hsa-miR-29c-3p JUN -0.00968972577705429 0.97099586346872 -2.04611084807692 9.1524625995215e-13 miRNAWalker2_validate -0.270579553256343 3.66051574994211e-07 NA NA NA hsa-miR-32-5p JUN 2.34056473219422 6.24134585974322e-20 -2.04611084807692 9.1524625995215e-13 miRNATAP -0.413566434466745 1.10620082409085e-15 NA NA NA hsa-miR-342-3p JUN 1.49115144672245 1.43879249744621e-07 -2.04611084807692 9.1524625995215e-13 miRNAWalker2_validate -0.133321520548688 0.00731127636739181 NA NA NA hsa-miR-34a-3p JUN 1.75590866103657 8.02801510630657e-09 -2.04611084807692 9.1524625995215e-13 MirTarget -0.279858707540387 3.1061995990995e-08 NA NA NA hsa-miR-429 JUN 4.48815175680773 2.44117492218206e-17 -2.04611084807692 9.1524625995215e-13 MirTarget;PITA;miRanda;miRNATAP -0.188635161083758 5.14832375488061e-14 NA NA NA hsa-miR-455-3p JUN 3.06093594997644 3.54590649799868e-16 -2.04611084807692 9.1524625995215e-13 miRNATAP -0.112839225766699 0.00201102151546805 NA NA NA hsa-miR-501-5p JUN 1.93654809410041 1.3779381780759e-10 -2.04611084807692 9.1524625995215e-13 MirTarget;PITA;miRNATAP -0.24236112135519 2.74349787240435e-07 NA NA NA hsa-miR-542-3p JUN 1.18832665895751 1.98700670691565e-07 -2.04611084807692 9.1524625995215e-13 miRanda -0.2224781000711 0.000312275738377628 NA NA NA hsa-miR-590-3p JUN 2.59289455139753 1.03200520972022e-21 -2.04611084807692 9.1524625995215e-13 miRanda -0.362021445664138 5.65305416742662e-13 NA NA NA hsa-miR-92a-3p JUN 2.06460102658973 1.44784291084757e-19 -2.04611084807692 9.1524625995215e-13 miRNATAP -0.395074792110845 1.74644010636679e-11 NA NA NA hsa-miR-93-5p JUN 3.03961860136032 1.11672209617395e-24 -2.04611084807692 9.1524625995215e-13 miRNAWalker2_validate -0.361575830576226 1.64388759918119e-16 NA NA NA hsa-miR-940 JUN 3.21011374578759 2.7923171128495e-14 -2.04611084807692 9.1524625995215e-13 MirTarget;PITA;miRNATAP -0.231773307807484 3.31037401763421e-11 NA NA NA hsa-miR-26b-5p LEF1 0.885393662798425 3.2116297961629e-06 0.331269268157301 0.289787632933989 miRNATAP -0.274638576592703 0.000542709321878361 24785257 miR26b is downregulated in several cancers and tumors and miR26b directly targets the lymphoid enhancer factor 1 Lef13'UTR and inhibits endogenous Lef1 expression; We report that miR26b expression is associated with human colon cancer through the regulation of LEF1 expression in colon cancer cells; Analyses of multiple colon cancer cell lines revealed an inverse correlation between miR26b and LEF1 expression; Normal human colon cells express low levels of LEF1 and high levels of miR26b; however human colon cancer cells have decreased miR26b expression and increased LEF1 expression; We demonstrate that miR26b expression is a potent inhibitor of colon cancer cell proliferation and significantly decreases LEF1 expression; Analyses of human colon cancer databases also demonstrated a link between miR26b and LEF1 expression colon cancer hsa-miR-320b LEF1 1.55692969039548 1.41071034251915e-08 0.331269268157301 0.289787632933989 miRanda;mirMAP -0.1663193228511 0.00218419474879364 NA NA NA hsa-miR-33a-3p LEF1 1.72765312072219 1.51784443453521e-07 0.331269268157301 0.289787632933989 miRNATAP -0.161646083992726 0.00116798280053409 NA NA NA hsa-miR-15a-5p LRP6 2.34669284378787 1.69544424500258e-23 -0.425710392411275 0.00843199937375149 miRNATAP -0.118743420320328 0.000165355028936229 NA NA NA hsa-miR-16-2-3p LRP6 2.31623086727196 4.29838149388188e-20 -0.425710392411275 0.00843199937375149 mirMAP -0.112567794182954 0.000140707519602626 NA NA NA hsa-miR-181a-5p LRP6 2.29556023480783 1.8138457900616e-21 -0.425710392411275 0.00843199937375149 mirMAP -0.129132535872795 2.72678840514503e-05 NA NA NA hsa-miR-29a-3p LRP6 -0.35074463683376 0.161238718982428 -0.425710392411275 0.00843199937375149 miRNATAP -0.156878645086471 4.42875484912951e-07 NA NA NA hsa-miR-29b-3p LRP6 1.65828197923813 1.02676780888141e-09 -0.425710392411275 0.00843199937375149 miRNATAP -0.223130059894877 3.36400735415803e-16 NA NA NA hsa-miR-130a-3p MAPK10 2.02021855058359 1.26427102520415e-11 -1.39613685607096 0.000971935890100464 miRNATAP -0.425271273370886 1.25010595009869e-10 NA NA NA hsa-miR-130b-3p MAPK10 3.5350292994509 1.73934183852569e-27 -1.39613685607096 0.000971935890100464 miRNATAP -0.157308872211673 0.00795632424961394 NA NA NA hsa-miR-146b-5p MAPK10 1.75587235896724 1.15724631266659e-07 -1.39613685607096 0.000971935890100464 miRanda -0.590131350156063 2.34286000506143e-24 NA NA NA hsa-miR-193a-3p MAPK10 1.60460546928078 2.86169793322984e-07 -1.39613685607096 0.000971935890100464 miRanda;miRNATAP -0.42329172270216 2.92418176925891e-11 NA NA NA hsa-miR-19a-3p MAPK10 3.42309334186656 3.02671914353412e-28 -1.39613685607096 0.000971935890100464 miRNATAP -0.250292411807473 4.93781898025515e-05 NA NA NA hsa-miR-19b-3p MAPK10 2.49529833021187 1.57028265846699e-23 -1.39613685607096 0.000971935890100464 miRNATAP -0.229843185806225 0.00332174049363652 NA NA NA hsa-miR-221-3p MAPK10 0.451556679024397 0.0909808299917811 -1.39613685607096 0.000971935890100464 miRNATAP -0.397173855876525 2.05290544452981e-07 NA NA NA hsa-miR-222-3p MAPK10 0.851783756239071 0.00266783568486918 -1.39613685607096 0.000971935890100464 miRNATAP -0.438283382047286 7.66762618038364e-10 NA NA NA hsa-miR-29a-3p MAPK10 -0.35074463683376 0.161238718982428 -1.39613685607096 0.000971935890100464 miRNATAP -0.454036231063091 2.56598108627441e-08 NA NA NA hsa-miR-454-3p MAPK10 2.47234127820054 1.12878018736016e-21 -1.39613685607096 0.000971935890100464 miRNATAP -0.209297634977375 0.00734798897159457 NA NA NA hsa-miR-455-5p MAPK10 2.2582442061694 1.43472128037398e-13 -1.39613685607096 0.000971935890100464 miRanda -0.32061697262034 7.65297587236286e-07 NA NA NA hsa-miR-590-3p MAPK10 2.59289455139753 1.03200520972022e-21 -1.39613685607096 0.000971935890100464 miRanda;mirMAP -0.317298220210079 1.7873353325919e-05 NA NA NA hsa-miR-590-5p MAPK10 3.18300989862077 2.06813568597893e-26 -1.39613685607096 0.000971935890100464 PITA;miRanda;miRNATAP -0.243164269697615 0.00024023443868175 NA NA NA hsa-miR-125a-5p MAPK8 0.599529391575274 0.0102300147180307 -0.0756707943151755 0.760488436744535 miRNAWalker2_validate -0.204776391145867 6.53898244404679e-05 NA NA NA hsa-miR-195-3p MAPK8 -0.658653229922836 0.0142127125129199 -0.0756707943151755 0.760488436744535 mirMAP -0.125052773381987 0.00597119043582991 NA NA NA hsa-miR-30c-5p MAPK8 0.778774633108 0.000285599212429136 -0.0756707943151755 0.760488436744535 mirMAP -0.232507239110947 2.92068982830542e-05 NA NA NA hsa-miR-30e-5p MAPK8 1.23904909539663 1.35561917122157e-09 -0.0756707943151755 0.760488436744535 mirMAP -0.151898721585445 0.00886264348901288 NA NA NA hsa-miR-361-5p MAPK9 0.971859117235239 5.30236555707088e-09 -0.269800666047329 0.00867453220223943 miRanda -0.122061441096387 3.51350695967922e-05 NA NA NA hsa-miR-129-5p MMP7 -0.524170159980738 0.222582956006346 1.87673691573227 0.0132795389128491 miRanda -0.253598077260141 0.00363220438825741 NA NA NA hsa-let-7f-5p MYC 0.495648727272215 0.00355972741198794 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.302610362502413 0.00593577090066522 NA NA NA hsa-let-7g-5p MYC 1.20061455355116 1.50237505511483e-12 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate;miRTarBase -0.647634835001101 8.67569135821405e-10 NA NA NA hsa-miR-320a MYC 0.438165828017084 0.0390159073347133 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.270203083250914 0.00203008366284758 25736597 Furthermore progesterone P4 promoted the expression of miR-320a by repressing c-Myc expression while estrogen E2 exerted the opposite effect breast cancer hsa-miR-320b MYC 1.55692969039548 1.41071034251915e-08 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.211227042104883 0.00142753396089349 26487644 miR 320b suppresses cell proliferation by targeting c Myc in human colorectal cancer cells; Overexpression of miR-320b in CRC cells was statistically correlated with a decrease of cell growth in vitro and in vivo while c-MYC was identified as a target gene of miR-320b in CRC; Furthermore it was found that up-regulation of c-Myc can attenuate the effects induced by miR-320b; Our identification of c-MYC as a target gene of miR-320b provides new insights into the pathophysiology of CRC proliferation and identifies miR-320b as a novel therapeutic target for the treatment of CRC colorectal cancer hsa-miR-335-5p MYC 1.77247705492746 2.22457658872091e-06 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.15527675337735 0.00141118517916367 NA NA NA hsa-miR-34a-5p MYC 1.9016323452565 1.43092834643601e-14 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate;miRTarBase -0.359767953473847 5.62932761832786e-07 25572695;25686834;21460242;22159222;23640973;22830357;22235332 The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;miR 34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c Myc pathway;Myc mediated repression of microRNA 34a promotes high grade transformation of B cell lymphoma by dysregulation of FoxP1;MicroRNA 34a suppresses malignant transformation by targeting c Myc transcriptional complexes in human renal cell carcinoma; We investigated the functional effects of microRNA-34a miR-34a on c-Myc transcriptional complexes in renal cell carcinoma; miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region which was revealed by luciferase reporter assays; Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription indicating a novel role of miR-34a in the regulation of transcription by c-Myc;Among them miR-34a was also associated with poor prognosis in 2 independent series of leukemic and nodal MCL and in cooperation with high expression of the MYC oncogene;We report that miR-34a did not inhibit cell proliferation notwithstanding a marked down-regulation of c-MYC;MicroRNA 34a modulates c Myc transcriptional complexes to suppress malignancy in human prostate cancer cells; We studied the functional effects of miR-34a on c-Myc transcriptional complexes in PC-3 prostate cancer cells; miR-34a downregulated expression of c-Myc oncogene by targeting its 3' UTR as shown by luciferase reporter assays; This is the first report to document that miR-34a suppresses assembly and function of the c-Myc-Skp2-Miz1 complex that activates RhoA and the c-Myc-pTEFB complex that elongates transcription of various genes suggesting a novel role of miR-34a in the regulation of transcription by c-Myc complex ;;;malignant trasformation;worse prognosis;; bladder cancer;liver cancer;B cell lymphoma;kidney renal cell cancer;lymphoma;lymphoma;prostate cancer hsa-miR-423-5p MYC 0.963563145758616 9.86109015204915e-07 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.592117097378242 1.10389937335588e-10 NA NA NA hsa-miR-429 MYC 4.48815175680773 2.44117492218206e-17 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.269400502460394 6.09134482841112e-17 21684154;24633485 miR 429 modulates the expression of c myc in human gastric carcinoma cells; SGC-7901 gastric cancer cells were transfected with miR-429 mimics and endogenous c-myc expression was detected by western blots; We performed functional assays using the 3'UTR of the c-myc gene as a miR-429 target in a luciferase reporter assay system; miR-429 significantly downregulated endogenous c-myc expression in SGC-7901 cells; Action of miR/429 on c-myc 3'UTR was confirmed; c-myc is an important miR-429 target gene;It is known that miR-429 is down-regulated and functions as a tumor suppressor by targeting c-myc and PLGG1 in gastric and breast cancer ; gastric cancer;sarcoma hsa-miR-744-5p MYC 1.48254348878737 3.23019501613577e-09 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.254793177391621 0.000439915184612437 24991193 Decrease expression of microRNA 744 promotes cell proliferation by targeting c Myc in human hepatocellular carcinoma; Quantitative reverse-transcription polymerase chain reaction qRT-PCR was conducted to detect the expression of miR-744 and Immunohistochemistry was performed to detect expression of c-Myc in HCC specimens and adjacent normal tissues; Luciferase reporter assays was performed to confirm whether miR-744 regulated the expression of c-Myc; Luciferase assay and Western blot analysis revealed that c-Myc is a direct target of miR-744; Down-regulation of miR-744 and up-regulation of c-Myc were detected in HCC specimens compared with adjacent normal tissues; Moreover restoration of miR-744 rescues c-Myc induced HCC proliferation; Our data suggest that miR-744 exerts its tumor suppressor function by targeting c-Myc leading to the inhibition of HCC cell growth liver cancer hsa-miR-98-5p MYC 1.11154309866014 1.24143909012085e-08 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate;miRTarBase -0.602921793997467 5.7325871539819e-11 NA NA NA hsa-miR-146b-5p NFAT5 1.75587235896724 1.15724631266659e-07 -0.392833700410932 0.0377471321681522 miRanda -0.153971114303279 9.27272608710862e-09 NA NA NA hsa-miR-148a-3p NFAT5 1.26728238710376 2.52325607402829e-06 -0.392833700410932 0.0377471321681522 miRNATAP -0.102833049736599 0.0022445738911715 NA NA NA hsa-miR-155-5p NFAT5 1.20164021433135 0.00086170622431261 -0.392833700410932 0.0377471321681522 mirMAP;miRNATAP -0.132036023095404 1.17438455270541e-07 NA NA NA hsa-miR-15b-3p NFAT5 2.33847028227712 4.29662877950836e-19 -0.392833700410932 0.0377471321681522 mirMAP -0.105075014155593 0.00169123758741249 NA NA NA hsa-miR-15b-5p NFAT5 1.57112623124278 9.14247846750597e-13 -0.392833700410932 0.0377471321681522 MirTarget -0.142553701038326 0.000445429182940406 NA NA NA hsa-miR-17-3p NFAT5 2.2704817679209 1.1667437320211e-22 -0.392833700410932 0.0377471321681522 mirMAP -0.156781273910673 2.73481212608122e-05 NA NA NA hsa-miR-17-5p NFAT5 3.2710598467455 9.93128340539455e-27 -0.392833700410932 0.0377471321681522 miRNAWalker2_validate;MirTarget;TargetScan;miRNATAP -0.130692587121015 2.70754809666796e-06 NA NA NA hsa-miR-186-5p NFAT5 1.47445398888668 3.0781726595413e-15 -0.392833700410932 0.0377471321681522 MirTarget;mirMAP -0.164781957469426 0.000548507264256057 NA NA NA hsa-miR-18a-5p NFAT5 3.78535678765353 3.72446596213886e-26 -0.392833700410932 0.0377471321681522 MirTarget;miRNATAP -0.131263409331572 1.65685429541776e-07 NA NA NA hsa-miR-193a-3p NFAT5 1.60460546928078 2.86169793322984e-07 -0.392833700410932 0.0377471321681522 miRanda -0.154805940441061 5.65348218966617e-08 NA NA NA hsa-miR-20a-5p NFAT5 3.15577933619191 4.19753346442454e-25 -0.392833700410932 0.0377471321681522 MirTarget;miRNATAP -0.130133275869658 3.48894650319326e-06 NA NA NA hsa-miR-21-3p NFAT5 2.19296355304364 4.63665722759779e-15 -0.392833700410932 0.0377471321681522 MirTarget -0.142374696456314 5.86977917811346e-06 NA NA NA hsa-miR-21-5p NFAT5 2.73773305747971 1.38864982139576e-43 -0.392833700410932 0.0377471321681522 miRNAWalker2_validate;mirMAP -0.137353463476768 0.0010230389162988 NA NA NA hsa-miR-25-3p NFAT5 1.36472605225697 4.83790725935681e-11 -0.392833700410932 0.0377471321681522 miRNATAP -0.160932569364308 0.000198217746469054 NA NA NA hsa-miR-29b-1-5p NFAT5 1.55384379072167 4.76870585070176e-05 -0.392833700410932 0.0377471321681522 MirTarget -0.108933017578416 1.32879285648522e-05 NA NA NA hsa-miR-338-5p NFAT5 -0.577691606146419 0.0472212680542825 -0.392833700410932 0.0377471321681522 MirTarget;PITA;mirMAP -0.125257085814405 7.29810204796898e-05 NA NA NA hsa-miR-340-5p NFAT5 0.30282999308409 0.157744789519131 -0.392833700410932 0.0377471321681522 MirTarget -0.151422565494268 0.000416794206059885 NA NA NA hsa-miR-361-3p NFAT5 1.07367425434318 1.73142774168958e-09 -0.392833700410932 0.0377471321681522 MirTarget;PITA;miRNATAP -0.183420224613813 0.000306310131071959 NA NA NA hsa-miR-362-5p NFAT5 1.59303749908759 9.582675908797e-08 -0.392833700410932 0.0377471321681522 mirMAP -0.15295196000171 3.09689810925579e-07 NA NA NA hsa-miR-365a-3p NFAT5 -0.0388985816963467 0.859114494267351 -0.392833700410932 0.0377471321681522 MirTarget -0.121321120716043 0.00395288593253482 NA NA NA hsa-miR-374a-3p NFAT5 0.533309330504947 0.00192918429705142 -0.392833700410932 0.0377471321681522 mirMAP -0.179441859225574 0.00082661585518594 NA NA NA hsa-miR-374b-5p NFAT5 0.0654362503857184 0.722673188879465 -0.392833700410932 0.0377471321681522 mirMAP;miRNATAP -0.138291681791848 0.00598798789718749 NA NA NA hsa-miR-500a-3p NFAT5 1.47161373123699 5.30571342631915e-09 -0.392833700410932 0.0377471321681522 MirTarget -0.194453706264052 3.59854094855025e-08 NA NA NA hsa-miR-500a-5p NFAT5 1.72110365584658 3.0807246212659e-10 -0.392833700410932 0.0377471321681522 mirMAP -0.137523536356053 2.56447700222189e-05 NA NA NA hsa-miR-511-5p NFAT5 1.04499312543772 0.00234126154508174 -0.392833700410932 0.0377471321681522 MirTarget -0.104679263781806 7.51885794085489e-05 NA NA NA hsa-miR-576-5p NFAT5 2.20467023993664 3.4053475193793e-19 -0.392833700410932 0.0377471321681522 MirTarget;PITA;mirMAP -0.125849037192384 0.000403381066087259 NA NA NA hsa-miR-589-3p NFAT5 2.51971841868825 2.39125940264107e-11 -0.392833700410932 0.0377471321681522 MirTarget -0.138187642380203 2.13896683508276e-07 NA NA NA hsa-miR-590-3p NFAT5 2.59289455139753 1.03200520972022e-21 -0.392833700410932 0.0377471321681522 MirTarget;miRanda;mirMAP;miRNATAP -0.112321248136072 0.000659914987197463 NA NA NA hsa-miR-590-5p NFAT5 3.18300989862077 2.06813568597893e-26 -0.392833700410932 0.0377471321681522 PITA;mirMAP;miRNATAP -0.113584598428477 0.000110657386354584 NA NA NA hsa-miR-7-1-3p NFAT5 1.84950311431067 1.25300363397654e-13 -0.392833700410932 0.0377471321681522 mirMAP -0.164682422606545 3.30852835931196e-06 NA NA NA hsa-miR-92a-3p NFAT5 2.06460102658973 1.44784291084757e-19 -0.392833700410932 0.0377471321681522 miRNATAP -0.170110315406311 8.64402750959781e-06 NA NA NA hsa-miR-92b-3p NFAT5 1.20409245530001 3.41055816361655e-06 -0.392833700410932 0.0377471321681522 miRNATAP -0.217775968771398 2.32261018870722e-10 NA NA NA hsa-miR-125a-5p NFATC1 0.599529391575274 0.0102300147180307 -1.85038550878621 5.2595171540405e-08 miRanda -0.271857756138489 0.000146359188361828 NA NA NA hsa-miR-3127-5p NFATC1 1.51846438737133 3.59571251672767e-07 -1.85038550878621 5.2595171540405e-08 MirTarget -0.249740036022457 5.5008583559068e-06 NA NA NA hsa-miR-421 NFATC1 1.17791565395543 6.78526676976629e-06 -1.85038550878621 5.2595171540405e-08 miRanda -0.285336719024401 6.2013105622129e-06 NA NA NA hsa-miR-940 NFATC1 3.21011374578759 2.7923171128495e-14 -1.85038550878621 5.2595171540405e-08 PITA -0.324901980633973 1.03105739407377e-15 NA NA NA hsa-miR-130b-5p NFATC2 2.9963110846538 1.98883029416455e-18 -2.09940213646525 2.77134949511158e-05 MirTarget -0.272734196833187 9.99532798497572e-05 NA NA NA hsa-miR-16-2-3p NFATC2 2.31623086727196 4.29838149388188e-20 -2.09940213646525 2.77134949511158e-05 mirMAP -0.346662368458709 0.000179256594294205 NA NA NA hsa-miR-182-5p NFATC2 3.53923166221814 5.07781258121574e-21 -2.09940213646525 2.77134949511158e-05 mirMAP -0.274974364845855 7.50815876894642e-06 NA NA NA hsa-miR-185-5p NFATC2 2.34016206907488 1.17481626642022e-26 -2.09940213646525 2.77134949511158e-05 MirTarget -0.377810783509097 0.000327278994012812 NA NA NA hsa-miR-186-5p NFATC2 1.47445398888668 3.0781726595413e-15 -2.09940213646525 2.77134949511158e-05 mirMAP -0.437555927141547 0.000604504699648039 NA NA NA hsa-miR-19a-3p NFATC2 3.42309334186656 3.02671914353412e-28 -2.09940213646525 2.77134949511158e-05 mirMAP -0.373437340706404 2.96351119749213e-07 NA NA NA hsa-miR-19b-3p NFATC2 2.49529833021187 1.57028265846699e-23 -2.09940213646525 2.77134949511158e-05 mirMAP -0.469765074696736 3.34509012953115e-07 NA NA NA hsa-miR-200b-5p NFATC2 2.54484902707822 1.59240467582976e-06 -2.09940213646525 2.77134949511158e-05 mirMAP -0.146133495085517 0.00444174699182292 NA NA NA hsa-miR-26b-3p NFATC2 2.18464160365372 2.11543189388328e-18 -2.09940213646525 2.77134949511158e-05 MirTarget -0.44806551147109 1.62954234122775e-06 NA NA NA hsa-miR-27b-5p NFATC2 0.393316367667332 0.051702301924024 -2.09940213646525 2.77134949511158e-05 mirMAP -0.365339117485442 0.00275776764973734 NA NA NA hsa-miR-29a-5p NFATC2 1.46749674755271 3.34605004270294e-07 -2.09940213646525 2.77134949511158e-05 mirMAP;miRNATAP -0.294077626911206 0.000928666235522722 NA NA NA hsa-miR-30c-5p NFATC2 0.778774633108 0.000285599212429136 -2.09940213646525 2.77134949511158e-05 MirTarget;mirMAP -0.368293366563006 0.00123567961865253 NA NA NA hsa-miR-30e-5p NFATC2 1.23904909539663 1.35561917122157e-09 -2.09940213646525 2.77134949511158e-05 MirTarget -0.336147434109482 0.00451047767094652 NA NA NA hsa-miR-320a NFATC2 0.438165828017084 0.0390159073347133 -2.09940213646525 2.77134949511158e-05 MirTarget -0.350663524320559 0.00250598418881894 NA NA NA hsa-miR-320b NFATC2 1.55692969039548 1.41071034251915e-08 -2.09940213646525 2.77134949511158e-05 MirTarget -0.249445194387165 0.00451696496700399 NA NA NA hsa-miR-34a-3p NFATC2 1.75590866103657 8.02801510630657e-09 -2.09940213646525 2.77134949511158e-05 mirMAP -0.301138281046132 0.000597201447878319 NA NA NA hsa-miR-3607-3p NFATC2 2.68532138541128 5.66716351955047e-14 -2.09940213646525 2.77134949511158e-05 MirTarget;mirMAP -0.321712713536906 1.93008019978856e-06 NA NA NA hsa-miR-3613-5p NFATC2 2.64358387329263 1.0373753017245e-24 -2.09940213646525 2.77134949511158e-05 mirMAP -0.582140424179043 1.2743589534383e-10 NA NA NA hsa-miR-484 NFATC2 1.81844463411787 1.82951571230938e-15 -2.09940213646525 2.77134949511158e-05 MirTarget -0.38479959768158 0.000202349753737943 NA NA NA hsa-miR-590-3p NFATC2 2.59289455139753 1.03200520972022e-21 -2.09940213646525 2.77134949511158e-05 mirMAP -0.321676608175333 0.000262933617887873 NA NA NA hsa-miR-7-1-3p NFATC2 1.84950311431067 1.25300363397654e-13 -2.09940213646525 2.77134949511158e-05 mirMAP -0.263604719151409 0.00578811798609279 NA NA NA hsa-miR-15a-5p NFATC3 2.34669284378787 1.69544424500258e-23 -0.344207804593337 0.00548033920348721 MirTarget;miRNATAP -0.129885441359854 5.57888748013133e-08 NA NA NA hsa-miR-222-3p NFATC3 0.851783756239071 0.00266783568486918 -0.344207804593337 0.00548033920348721 MirTarget;miRNATAP -0.110115490467549 1.25225883533778e-07 NA NA NA hsa-miR-29b-3p NFATC3 1.65828197923813 1.02676780888141e-09 -0.344207804593337 0.00548033920348721 MirTarget;miRNATAP -0.172204559034396 1.82486178909652e-16 NA NA NA hsa-miR-30c-5p NFATC3 0.778774633108 0.000285599212429136 -0.344207804593337 0.00548033920348721 MirTarget;miRNATAP -0.114740157277972 3.63344948530422e-05 NA NA NA hsa-miR-361-3p NFATC3 1.07367425434318 1.73142774168958e-09 -0.344207804593337 0.00548033920348721 miRNAWalker2_validate -0.187220216115042 1.24465306058345e-08 NA NA NA hsa-miR-130b-5p NFATC4 2.9963110846538 1.98883029416455e-18 -1.80092988307702 3.48834735342005e-10 mirMAP -0.137235836741862 0.000756045425262512 NA NA NA hsa-miR-15b-3p NFATC4 2.33847028227712 4.29662877950836e-19 -1.80092988307702 3.48834735342005e-10 mirMAP -0.42678455481147 1.50897022571625e-17 NA NA NA hsa-miR-181a-2-3p NFATC4 2.19062681262366 3.81790102612782e-13 -1.80092988307702 3.48834735342005e-10 mirMAP -0.195817485216201 1.65164425285929e-05 NA NA NA hsa-miR-181a-5p NFATC4 2.29556023480783 1.8138457900616e-21 -1.80092988307702 3.48834735342005e-10 mirMAP -0.232958279655687 3.02940033007413e-05 NA NA NA hsa-miR-181b-5p NFATC4 2.49307679431293 3.92829250217627e-20 -1.80092988307702 3.48834735342005e-10 mirMAP -0.262874063527659 1.04543846165047e-07 NA NA NA hsa-miR-185-3p NFATC4 2.3922478518806 1.3373426768452e-14 -1.80092988307702 3.48834735342005e-10 MirTarget -0.271046230259512 4.4211964130384e-10 NA NA NA hsa-miR-2355-5p NFATC4 1.32510310704724 8.25139516692683e-07 -1.80092988307702 3.48834735342005e-10 MirTarget -0.365394782747818 7.50941976584262e-13 NA NA NA hsa-miR-29b-3p NFATC4 1.65828197923813 1.02676780888141e-09 -1.80092988307702 3.48834735342005e-10 miRNATAP -0.215973494706709 2.3206094912252e-05 NA NA NA hsa-miR-320b NFATC4 1.55692969039548 1.41071034251915e-08 -1.80092988307702 3.48834735342005e-10 miRanda;mirMAP -0.260870260943582 2.24547536842287e-07 NA NA NA hsa-miR-34c-5p NFATC4 2.07190852984647 7.35776320806257e-08 -1.80092988307702 3.48834735342005e-10 miRanda -0.136831648591325 0.000394221428295672 NA NA NA hsa-miR-3607-3p NFATC4 2.68532138541128 5.66716351955047e-14 -1.80092988307702 3.48834735342005e-10 miRNATAP -0.251671136039063 8.25714813158393e-11 NA NA NA hsa-miR-361-3p NFATC4 1.07367425434318 1.73142774168958e-09 -1.80092988307702 3.48834735342005e-10 mirMAP -0.397492986056446 3.76815247508252e-07 NA NA NA hsa-miR-423-5p NFATC4 0.963563145758616 9.86109015204915e-07 -1.80092988307702 3.48834735342005e-10 miRNATAP -0.289483218215484 5.20887036793855e-05 NA NA NA hsa-miR-484 NFATC4 1.81844463411787 1.82951571230938e-15 -1.80092988307702 3.48834735342005e-10 MirTarget;miRNATAP -0.319008427014768 8.35906924043843e-08 NA NA NA hsa-miR-625-5p NFATC4 1.42540152147292 1.95797147911206e-06 -1.80092988307702 3.48834735342005e-10 mirMAP -0.255935845388402 5.19970914763295e-07 NA NA NA hsa-miR-629-3p NFATC4 2.36570947321815 1.33458201201618e-11 -1.80092988307702 3.48834735342005e-10 mirMAP -0.317779815801302 3.14548353729131e-13 NA NA NA hsa-miR-940 NFATC4 3.21011374578759 2.7923171128495e-14 -1.80092988307702 3.48834735342005e-10 miRNATAP -0.168817588938824 1.62478907216658e-06 NA NA NA hsa-let-7a-5p NKD1 0.618599506841644 2.76973453058748e-05 -1.69553775455222 4.2654677240011e-05 TargetScan -0.412393121442761 0.00297883843016037 NA NA NA hsa-miR-140-5p NKD1 0.844753502512594 3.73722278438606e-05 -1.69553775455222 4.2654677240011e-05 miRanda -0.379888847864967 0.000112585187849131 NA NA NA hsa-miR-188-5p NKD1 2.52825126596644 6.78099435999778e-14 -1.69553775455222 4.2654677240011e-05 PITA;miRNATAP -0.25778755790971 2.85927171482183e-05 NA NA NA hsa-miR-200b-3p NKD1 3.78235093249346 3.18343003239465e-14 -1.69553775455222 4.2654677240011e-05 TargetScan -0.138663429173362 0.000391152627853839 NA NA NA hsa-miR-21-5p NKD1 2.73773305747971 1.38864982139576e-43 -1.69553775455222 4.2654677240011e-05 mirMAP -0.242774511306372 0.00882769312079821 NA NA NA hsa-miR-330-5p NKD1 1.15100069700871 4.85551805046014e-07 -1.69553775455222 4.2654677240011e-05 miRanda;miRNATAP -0.255318110723475 0.00362539046247924 NA NA NA hsa-miR-361-5p NKD1 0.971859117235239 5.30236555707088e-09 -1.69553775455222 4.2654677240011e-05 miRanda -0.661066416940325 3.2521696823557e-08 NA NA NA hsa-miR-421 NKD1 1.17791565395543 6.78526676976629e-06 -1.69553775455222 4.2654677240011e-05 mirMAP -0.208279535015449 0.00680685931469785 NA NA NA hsa-miR-429 NKD1 4.48815175680773 2.44117492218206e-17 -1.69553775455222 4.2654677240011e-05 miRanda;miRNATAP -0.131409348751771 0.000313269516977655 NA NA NA hsa-miR-501-5p NKD1 1.93654809410041 1.3779381780759e-10 -1.69553775455222 4.2654677240011e-05 mirMAP -0.28165045795111 2.7945839052911e-05 NA NA NA hsa-miR-532-5p NKD1 1.55697650978597 1.57884735535196e-11 -1.69553775455222 4.2654677240011e-05 PITA;miRNATAP -0.414476725623264 1.11427017775432e-06 NA NA NA hsa-miR-944 NKD1 2.91186649218281 1.31574753528144e-06 -1.69553775455222 4.2654677240011e-05 PITA;miRNATAP -0.158771499517632 2.84615119182641e-06 NA NA NA hsa-miR-34c-5p NKD2 2.07190852984647 7.35776320806257e-08 0.271931543815029 0.619908302291644 miRanda -0.231239074132453 0.00137038057421905 NA NA NA hsa-miR-152-3p NLK -0.0480232621705712 0.844347735441565 0.7741568824418 1.00090143680282e-07 MirTarget -0.132317012289272 5.31854788819065e-06 NA NA NA hsa-miR-221-3p NLK 0.451556679024397 0.0909808299917811 0.7741568824418 1.00090143680282e-07 MirTarget;miRNATAP -0.191070870391673 2.07162907329332e-13 NA NA NA hsa-miR-222-3p NLK 0.851783756239071 0.00266783568486918 0.7741568824418 1.00090143680282e-07 MirTarget;miRNATAP -0.161713318218648 4.46385425959352e-11 NA NA NA hsa-miR-222-5p NLK 1.25632771414778 0.000138653440511922 0.7741568824418 1.00090143680282e-07 MirTarget -0.102776820884223 1.32608917229093e-06 NA NA NA hsa-miR-23a-3p NLK 1.00493340843378 2.55313889288924e-08 0.7741568824418 1.00090143680282e-07 miRNAWalker2_validate;MirTarget -0.117869946714833 0.00269411132634791 NA NA NA hsa-miR-27a-3p NLK 1.66542180327138 4.93775737894805e-13 0.7741568824418 1.00090143680282e-07 miRNATAP -0.107481035847716 0.000355550273210407 NA NA NA hsa-let-7g-3p PLCB1 3.26398061402445 3.96263126107645e-25 -1.22654831568585 1.86169905806194e-05 miRNATAP -0.117851489742216 0.00612130963578121 NA NA NA hsa-miR-130a-3p PLCB1 2.02021855058359 1.26427102520415e-11 -1.22654831568585 1.86169905806194e-05 miRNATAP -0.279568993258477 5.17653375953838e-10 NA NA NA hsa-miR-142-3p PLCB1 2.75247908790621 1.45636065474764e-12 -1.22654831568585 1.86169905806194e-05 PITA;miRanda;miRNATAP -0.231796906425099 1.2098283776891e-11 NA NA NA hsa-miR-16-2-3p PLCB1 2.31623086727196 4.29838149388188e-20 -1.22654831568585 1.86169905806194e-05 mirMAP -0.223877224368459 2.22768365709891e-05 NA NA NA hsa-miR-17-5p PLCB1 3.2710598467455 9.93128340539455e-27 -1.22654831568585 1.86169905806194e-05 TargetScan;miRNATAP -0.204697568987788 1.53998074729487e-06 NA NA NA hsa-miR-199a-3p PLCB1 0.640600337515787 0.0380326905134914 -1.22654831568585 1.86169905806194e-05 PITA -0.180962722425954 6.01724618035789e-05 NA NA NA hsa-miR-199b-3p PLCB1 0.643923492750702 0.0371742251925406 -1.22654831568585 1.86169905806194e-05 PITA;miRNATAP -0.18080748117115 6.03252708655506e-05 NA NA NA hsa-miR-19a-3p PLCB1 3.42309334186656 3.02671914353412e-28 -1.22654831568585 1.86169905806194e-05 miRNATAP -0.23730332953265 1.08406621353532e-08 NA NA NA hsa-miR-19b-3p PLCB1 2.49529833021187 1.57028265846699e-23 -1.22654831568585 1.86169905806194e-05 miRNATAP -0.27764045741269 1.29658147732859e-07 NA NA NA hsa-miR-20a-5p PLCB1 3.15577933619191 4.19753346442454e-25 -1.22654831568585 1.86169905806194e-05 miRNATAP -0.216285857713586 4.37565227309454e-07 NA NA NA hsa-miR-34c-5p PLCB1 2.07190852984647 7.35776320806257e-08 -1.22654831568585 1.86169905806194e-05 miRanda;miRNATAP -0.118545579749077 0.0018830176356004 NA NA NA hsa-miR-454-3p PLCB1 2.47234127820054 1.12878018736016e-21 -1.22654831568585 1.86169905806194e-05 miRNATAP -0.201209424521376 0.000139541808512969 NA NA NA hsa-miR-590-3p PLCB1 2.59289455139753 1.03200520972022e-21 -1.22654831568585 1.86169905806194e-05 PITA;miRanda;mirMAP -0.221180724656213 1.06568034827934e-05 NA NA NA hsa-miR-590-5p PLCB1 3.18300989862077 2.06813568597893e-26 -1.22654831568585 1.86169905806194e-05 PITA;miRanda -0.183763729055552 4.2729282083522e-05 NA NA NA hsa-miR-7-1-3p PLCB1 1.84950311431067 1.25300363397654e-13 -1.22654831568585 1.86169905806194e-05 mirMAP -0.169113372082461 0.00193959166385676 NA NA NA hsa-miR-7-5p PLCB1 2.28980165299999 1.5131097560452e-07 -1.22654831568585 1.86169905806194e-05 miRNATAP -0.134786129598053 6.91761463727059e-05 NA NA NA hsa-miR-3065-5p PLCB2 2.74629919868982 1.86846589298284e-08 -0.363600498312653 0.280344756168823 miRNATAP -0.115625789033607 0.00397271578867514 NA NA NA hsa-let-7a-3p PLCB4 1.42015538786275 7.03375209382654e-13 -3.76947582666435 4.09541818232216e-14 mirMAP;miRNATAP -0.83254422778899 5.59274705865604e-12 NA NA NA hsa-let-7a-5p PLCB4 0.618599506841644 2.76973453058748e-05 -3.76947582666435 4.09541818232216e-14 miRNATAP -0.487033219905897 0.00445261480865196 NA NA NA hsa-let-7b-3p PLCB4 0.868207752019623 1.30460056774366e-05 -3.76947582666435 4.09541818232216e-14 mirMAP;miRNATAP -0.707112138165477 1.00040779115694e-08 NA NA NA hsa-let-7b-5p PLCB4 0.604314269683977 0.00140009936153214 -3.76947582666435 4.09541818232216e-14 miRNATAP -0.455031465278346 0.000590887935416328 NA NA NA hsa-let-7f-1-3p PLCB4 1.55054488387679 7.31326775537952e-11 -3.76947582666435 4.09541818232216e-14 mirMAP -0.709444351435182 7.04182417212984e-12 NA NA NA hsa-let-7g-5p PLCB4 1.20061455355116 1.50237505511483e-12 -3.76947582666435 4.09541818232216e-14 miRNATAP -0.612876579587926 2.13309385488441e-05 NA NA NA hsa-let-7i-5p PLCB4 0.412877696970403 0.00622731051981756 -3.76947582666435 4.09541818232216e-14 miRNATAP -0.759861175681747 5.3771519085834e-06 NA NA NA hsa-miR-141-3p PLCB4 5.02396127982626 2.19224509139725e-24 -3.76947582666435 4.09541818232216e-14 TargetScan -0.288518356683351 6.78415934849381e-10 NA NA NA hsa-miR-16-2-3p PLCB4 2.31623086727196 4.29838149388188e-20 -3.76947582666435 4.09541818232216e-14 mirMAP -0.822927554545324 1.05250980874373e-19 NA NA NA hsa-miR-183-5p PLCB4 4.19757025992371 4.79612296318304e-26 -3.76947582666435 4.09541818232216e-14 miRNATAP -0.247838543657893 2.24805923634678e-05 NA NA NA hsa-miR-23a-3p PLCB4 1.00493340843378 2.55313889288924e-08 -3.76947582666435 4.09541818232216e-14 miRNATAP -1.16100967819954 1.63098743065023e-18 NA NA NA hsa-miR-26b-5p PLCB4 0.885393662798425 3.2116297961629e-06 -3.76947582666435 4.09541818232216e-14 miRNAWalker2_validate -0.77108874483763 2.27781944637492e-09 NA NA NA hsa-miR-361-5p PLCB4 0.971859117235239 5.30236555707088e-09 -3.76947582666435 4.09541818232216e-14 miRanda -0.459154534994574 0.00209783633322442 NA NA NA hsa-miR-429 PLCB4 4.48815175680773 2.44117492218206e-17 -3.76947582666435 4.09541818232216e-14 miRanda -0.139545329701844 0.00194429585078748 NA NA NA hsa-miR-450b-5p PLCB4 1.69244418548325 1.68064054148881e-10 -3.76947582666435 4.09541818232216e-14 PITA;mirMAP -0.350535095559098 0.000138134023890591 NA NA NA hsa-miR-454-3p PLCB4 2.47234127820054 1.12878018736016e-21 -3.76947582666435 4.09541818232216e-14 miRNATAP -0.578117115173462 4.64511654720209e-10 NA NA NA hsa-miR-455-5p PLCB4 2.2582442061694 1.43472128037398e-13 -3.76947582666435 4.09541818232216e-14 PITA;miRanda -0.612873661319147 1.38103686478768e-15 NA NA NA hsa-miR-590-3p PLCB4 2.59289455139753 1.03200520972022e-21 -3.76947582666435 4.09541818232216e-14 miRanda -0.612962269746204 3.23888281679726e-12 NA NA NA hsa-miR-708-3p PLCB4 2.80907765282502 3.07460722669281e-14 -3.76947582666435 4.09541818232216e-14 miRNATAP -0.255327866063613 8.45068312511941e-05 NA NA NA hsa-miR-944 PLCB4 2.91186649218281 1.31574753528144e-06 -3.76947582666435 4.09541818232216e-14 mirMAP -0.335476024390202 1.67898371983472e-16 NA NA NA hsa-miR-96-5p PLCB4 4.89433085814374 1.92000659886961e-31 -3.76947582666435 4.09541818232216e-14 TargetScan;miRNATAP -0.286158803012001 3.01857097238531e-07 NA NA NA hsa-miR-195-5p PPARD -1.44753678070504 8.70594292149271e-09 0.158106147983019 0.323762248656779 mirMAP -0.113965903793204 0.000159774091045989 NA NA NA hsa-miR-183-5p PPP2CB 4.19757025992371 4.79612296318304e-26 -0.783679156108793 2.67817932533534e-08 MirTarget;miRNATAP -0.115935862473986 2.8039910681077e-13 NA NA NA hsa-miR-32-3p PPP2CB 2.02436999565685 5.94091197945307e-09 -0.783679156108793 2.67817932533534e-08 MirTarget -0.105750464768045 1.64351977471817e-06 NA NA NA hsa-miR-361-5p PPP2CB 0.971859117235239 5.30236555707088e-09 -0.783679156108793 2.67817932533534e-08 miRanda -0.206656922572491 4.60021445788998e-07 NA NA NA hsa-miR-425-5p PPP2CB 3.07071373939774 4.02947460586085e-25 -0.783679156108793 2.67817932533534e-08 miRNAWalker2_validate -0.185494581813071 1.46832581012673e-18 NA NA NA hsa-miR-107 PPP2R5A 1.30977326593435 1.30372468603965e-11 -0.903448375131664 8.39328972558812e-12 miRanda -0.224947751657196 4.70987626884361e-12 NA NA NA hsa-miR-197-3p PPP2R5A 1.75733174019505 8.88576793100499e-13 -0.903448375131664 8.39328972558812e-12 MirTarget -0.168187304798222 3.80039885887156e-11 NA NA NA hsa-miR-34a-5p PPP2R5A 1.9016323452565 1.43092834643601e-14 -0.903448375131664 8.39328972558812e-12 MirTarget;miRNATAP -0.101688531317395 7.12383430257492e-05 NA NA NA hsa-miR-455-5p PPP2R5A 2.2582442061694 1.43472128037398e-13 -0.903448375131664 8.39328972558812e-12 miRanda -0.109914486969236 8.84512455058286e-08 NA NA NA hsa-miR-484 PPP2R5A 1.81844463411787 1.82951571230938e-15 -0.903448375131664 8.39328972558812e-12 miRNAWalker2_validate -0.16770839153884 8.04350521732411e-10 NA NA NA hsa-miR-590-3p PPP2R5A 2.59289455139753 1.03200520972022e-21 -0.903448375131664 8.39328972558812e-12 miRNAWalker2_validate -0.153925977316081 2.89830567232078e-11 NA NA NA hsa-miR-744-5p PPP2R5B 1.48254348878737 3.23019501613577e-09 -0.31859896881852 0.0287055664679159 MirTarget -0.11714720009535 2.06087544503158e-05 NA NA NA hsa-miR-125a-5p PPP2R5C 0.599529391575274 0.0102300147180307 -0.521480329500893 1.91945462921615e-07 MirTarget;PITA;miRanda -0.115314852256606 2.48746606736075e-08 NA NA NA hsa-miR-140-3p PPP2R5C 0.0608890720479334 0.727716871248724 -0.521480329500893 1.91945462921615e-07 MirTarget -0.112361878880438 6.83972421205159e-05 NA NA NA hsa-miR-186-5p PPP2R5C 1.47445398888668 3.0781726595413e-15 -0.521480329500893 1.91945462921615e-07 mirMAP;miRNATAP -0.138496919779324 3.715710908355e-08 NA NA NA hsa-miR-101-5p PPP2R5E 0.782067874775122 0.00443725251526842 -0.277275686002286 0.0553819870972808 MirTarget -0.127293557994918 9.10136825621678e-07 NA NA NA hsa-miR-125a-5p PPP2R5E 0.599529391575274 0.0102300147180307 -0.277275686002286 0.0553819870972808 miRNAWalker2_validate -0.203094773845661 4.35836001954904e-12 NA NA NA hsa-miR-181a-5p PPP2R5E 2.29556023480783 1.8138457900616e-21 -0.277275686002286 0.0553819870972808 MirTarget;mirMAP -0.134280374282853 9.42260409675176e-07 NA NA NA hsa-miR-181c-5p PPP2R5E 1.58587920618301 1.57506918816933e-10 -0.277275686002286 0.0553819870972808 MirTarget;mirMAP -0.135897759869079 7.11089574419858e-07 NA NA NA hsa-miR-29b-2-5p PPP2R5E 0.910668640983475 0.00666655585493488 -0.277275686002286 0.0553819870972808 mirMAP -0.120756928794226 3.55710707680044e-09 NA NA NA hsa-miR-30a-5p PPP2R5E -0.878357906436456 0.000509952992366057 -0.277275686002286 0.0553819870972808 mirMAP -0.111175309666902 5.16408706706393e-05 NA NA NA hsa-miR-30b-5p PPP2R5E 0.800822374912712 0.000133601914525413 -0.277275686002286 0.0553819870972808 mirMAP -0.100564762573576 0.00255890060927322 NA NA NA hsa-miR-30c-5p PPP2R5E 0.778774633108 0.000285599212429136 -0.277275686002286 0.0553819870972808 mirMAP -0.196572491249197 8.38970528577029e-10 NA NA NA hsa-miR-30e-5p PPP2R5E 1.23904909539663 1.35561917122157e-09 -0.277275686002286 0.0553819870972808 mirMAP -0.152449869597762 5.47961799645938e-06 NA NA NA hsa-let-7f-5p PPP3CA 0.495648727272215 0.00355972741198794 -0.281979431665802 0.0843014975757299 miRNATAP -0.145174821876866 0.00196996187493329 NA NA NA hsa-let-7g-5p PPP3CA 1.20061455355116 1.50237505511483e-12 -0.281979431665802 0.0843014975757299 miRNATAP -0.256650979931267 1.4045207283454e-08 NA NA NA hsa-miR-106a-5p PPP3CA 2.48882002962836 1.99757727374521e-12 -0.281979431665802 0.0843014975757299 miRNATAP -0.11191172835948 1.79556273427309e-07 NA NA NA hsa-miR-106b-5p PPP3CA 2.46782146831112 1.36171495805632e-23 -0.281979431665802 0.0843014975757299 miRNATAP -0.184105953911301 6.84398280050895e-10 NA NA NA hsa-miR-17-3p PPP3CA 2.2704817679209 1.1667437320211e-22 -0.281979431665802 0.0843014975757299 MirTarget -0.131133816129638 4.79999765543855e-05 NA NA NA hsa-miR-186-5p PPP3CA 1.47445398888668 3.0781726595413e-15 -0.281979431665802 0.0843014975757299 mirMAP -0.185694598107894 5.66511837519636e-06 NA NA NA hsa-miR-194-5p PPP3CA 1.8992998339217 3.76507853301977e-10 -0.281979431665802 0.0843014975757299 MirTarget -0.17070662815415 7.35898582017249e-12 NA NA NA hsa-miR-20a-5p PPP3CA 3.15577933619191 4.19753346442454e-25 -0.281979431665802 0.0843014975757299 miRNATAP -0.109419648077418 6.17460161232474e-06 NA NA NA hsa-miR-20b-5p PPP3CA 2.07706563022469 1.10107236083433e-05 -0.281979431665802 0.0843014975757299 miRNATAP -0.113387749946454 1.85473104688059e-12 NA NA NA hsa-miR-30c-5p PPP3CA 0.778774633108 0.000285599212429136 -0.281979431665802 0.0843014975757299 miRNATAP -0.212081199369466 4.85681407465908e-09 NA NA NA hsa-miR-30d-5p PPP3CA 0.675423997639582 0.00270618816039773 -0.281979431665802 0.0843014975757299 miRNATAP -0.142883121139453 4.34068465949306e-05 NA NA NA hsa-miR-501-3p PPP3CA 1.83132758513743 1.10971547702065e-10 -0.281979431665802 0.0843014975757299 MirTarget;PITA;miRNATAP -0.114452652427796 2.34298968304304e-05 NA NA NA hsa-miR-502-3p PPP3CA 1.50560877085049 1.2647489756373e-11 -0.281979431665802 0.0843014975757299 MirTarget;PITA;miRNATAP -0.15529134445823 7.08901270771209e-06 NA NA NA hsa-miR-664a-3p PPP3CA 0.634721925861133 0.00520070178640421 -0.281979431665802 0.0843014975757299 mirMAP -0.150747155909677 1.3336356409105e-05 NA NA NA hsa-miR-7-1-3p PPP3CA 1.84950311431067 1.25300363397654e-13 -0.281979431665802 0.0843014975757299 MirTarget;mirMAP -0.119727173710851 9.40140707131449e-05 NA NA NA hsa-miR-93-3p PPP3CA 2.85383869771942 5.64481766902125e-23 -0.281979431665802 0.0843014975757299 miRNATAP -0.152353546507485 2.15079066361371e-09 NA NA NA hsa-miR-93-5p PPP3CA 3.03961860136032 1.11672209617395e-24 -0.281979431665802 0.0843014975757299 miRNATAP -0.156066415468858 2.44288871078656e-10 NA NA NA hsa-miR-107 PPP3CB 1.30977326593435 1.30372468603965e-11 -1.03671584843429 6.12489584217064e-15 miRanda -0.224024061633064 1.13198598297881e-11 NA NA NA hsa-miR-15a-5p PPP3CB 2.34669284378787 1.69544424500258e-23 -1.03671584843429 6.12489584217064e-15 miRNATAP -0.188034579267018 6.2219880807044e-13 NA NA NA hsa-miR-15b-5p PPP3CB 1.57112623124278 9.14247846750597e-13 -1.03671584843429 6.12489584217064e-15 miRNATAP -0.245380830384666 5.15260568991425e-18 NA NA NA hsa-miR-16-5p PPP3CB 1.75824877145857 1.68592440033108e-16 -1.03671584843429 6.12489584217064e-15 miRNATAP -0.219222038672189 7.36535140884335e-14 NA NA NA hsa-miR-20a-3p PPP3CB 2.92621109947706 2.49504904635375e-17 -1.03671584843429 6.12489584217064e-15 miRNATAP -0.113868623377048 9.37084199962394e-10 NA NA NA hsa-miR-26b-5p PPP3CB 0.885393662798425 3.2116297961629e-06 -1.03671584843429 6.12489584217064e-15 MirTarget;miRNATAP -0.129362759155204 0.000196474595826764 NA NA NA hsa-miR-30c-5p PPP3CB 0.778774633108 0.000285599212429136 -1.03671584843429 6.12489584217064e-15 miRNATAP -0.165551300673001 5.92944884537219e-08 NA NA NA hsa-miR-30d-5p PPP3CB 0.675423997639582 0.00270618816039773 -1.03671584843429 6.12489584217064e-15 miRNATAP -0.128345099197797 1.20380214861929e-05 NA NA NA hsa-miR-320a PPP3CB 0.438165828017084 0.0390159073347133 -1.03671584843429 6.12489584217064e-15 miRanda -0.133683103961461 1.89473747516991e-05 NA NA NA hsa-miR-320b PPP3CB 1.55692969039548 1.41071034251915e-08 -1.03671584843429 6.12489584217064e-15 miRanda -0.157984627594008 1.12882018634839e-11 NA NA NA hsa-miR-330-5p PPP3CB 1.15100069700871 4.85551805046014e-07 -1.03671584843429 6.12489584217064e-15 MirTarget;PITA;miRanda -0.122279132326624 1.90117350044819e-05 NA NA NA hsa-miR-339-5p PPP3CB 2.68710938429893 3.03134080808154e-16 -1.03671584843429 6.12489584217064e-15 miRanda -0.129274316344838 1.00359131009696e-11 NA NA NA hsa-miR-361-5p PPP3CB 0.971859117235239 5.30236555707088e-09 -1.03671584843429 6.12489584217064e-15 miRanda -0.319599472524393 7.32960352437588e-17 NA NA NA hsa-miR-421 PPP3CB 1.17791565395543 6.78526676976629e-06 -1.03671584843429 6.12489584217064e-15 miRanda -0.107753543524587 1.70411972807069e-05 NA NA NA hsa-miR-429 PPP3CB 4.48815175680773 2.44117492218206e-17 -1.03671584843429 6.12489584217064e-15 miRanda -0.104170748345545 1.10824048087982e-19 NA NA NA hsa-miR-501-5p PPP3CB 1.93654809410041 1.3779381780759e-10 -1.03671584843429 6.12489584217064e-15 PITA;miRNATAP -0.110941325807012 4.19796167603695e-07 NA NA NA hsa-miR-590-3p PPP3CB 2.59289455139753 1.03200520972022e-21 -1.03671584843429 6.12489584217064e-15 miRanda -0.160737546369274 6.57567642585996e-12 NA NA NA hsa-miR-7-1-3p PPP3CB 1.84950311431067 1.25300363397654e-13 -1.03671584843429 6.12489584217064e-15 mirMAP -0.170702158890249 1.5272735318301e-11 NA NA NA hsa-miR-361-5p PPP3CC 0.971859117235239 5.30236555707088e-09 -0.895441456978914 1.07671854464434e-07 miRanda -0.275565592476708 1.65394541713718e-08 NA NA NA hsa-miR-500a-3p PPP3CC 1.47161373123699 5.30571342631915e-09 -0.895441456978914 1.07671854464434e-07 MirTarget;miRNATAP -0.11299814981742 0.000453955248711429 NA NA NA hsa-miR-502-3p PPP3CC 1.50560877085049 1.2647489756373e-11 -0.895441456978914 1.07671854464434e-07 MirTarget;PITA;miRNATAP -0.137316418088144 0.000157963764790067 NA NA NA hsa-miR-101-3p PPP3R1 0.522819989585461 0.00375627731618038 -0.0284423401171923 0.760566460331176 miRNATAP -0.130896280595902 1.18496266678438e-07 NA NA NA hsa-miR-125a-5p PRICKLE1 0.599529391575274 0.0102300147180307 -1.64440101214105 0.000132852800511825 miRanda -0.485707966204348 4.90641983848895e-08 NA NA NA hsa-miR-141-3p PRICKLE1 5.02396127982626 2.19224509139725e-24 -1.64440101214105 0.000132852800511825 TargetScan -0.396289457266669 8.83434530890621e-26 NA NA NA hsa-miR-17-5p PRICKLE1 3.2710598467455 9.93128340539455e-27 -1.64440101214105 0.000132852800511825 miRNAWalker2_validate -0.489501669242094 4.60900383839463e-15 NA NA NA hsa-miR-192-5p PRICKLE1 2.69002528723195 1.22990188194432e-16 -1.64440101214105 0.000132852800511825 miRNAWalker2_validate -0.455771322391911 4.6556373418372e-14 NA NA NA hsa-miR-215-5p PRICKLE1 2.30755467422978 2.38476032118039e-06 -1.64440101214105 0.000132852800511825 miRNAWalker2_validate -0.245291041077268 1.16245824881457e-08 NA NA NA hsa-miR-3065-5p PRICKLE1 2.74629919868982 1.86846589298284e-08 -1.64440101214105 0.000132852800511825 mirMAP -0.152016333628324 0.00328111905239581 NA NA NA hsa-miR-30b-5p PRICKLE1 0.800822374912712 0.000133601914525413 -1.64440101214105 0.000132852800511825 mirMAP -0.556999598749772 1.74176304546946e-08 NA NA NA hsa-miR-30c-5p PRICKLE1 0.778774633108 0.000285599212429136 -1.64440101214105 0.000132852800511825 miRNATAP -0.690897609672426 4.39705498162092e-13 NA NA NA hsa-miR-30d-5p PRICKLE1 0.675423997639582 0.00270618816039773 -1.64440101214105 0.000132852800511825 miRNATAP -0.800379169580136 4.22770315021246e-19 NA NA NA hsa-miR-330-3p PRICKLE1 0.876747334239085 0.00073709016089703 -1.64440101214105 0.000132852800511825 mirMAP;miRNATAP -0.622179397459892 1.62080967848238e-15 NA NA NA hsa-miR-3607-3p PRICKLE1 2.68532138541128 5.66716351955047e-14 -1.64440101214105 0.000132852800511825 miRNATAP -0.42357423492522 9.31132101711317e-14 NA NA NA hsa-miR-361-5p PRICKLE1 0.971859117235239 5.30236555707088e-09 -1.64440101214105 0.000132852800511825 miRanda -0.963716571594244 2.51074214624177e-15 NA NA NA hsa-miR-532-5p PRICKLE1 1.55697650978597 1.57884735535196e-11 -1.64440101214105 0.000132852800511825 miRNATAP -0.573355511222263 5.09728697524232e-11 NA NA NA hsa-miR-582-5p PRICKLE1 0.609226359812689 0.032988717891497 -1.64440101214105 0.000132852800511825 miRNATAP -0.453563873692779 3.28256113485855e-10 NA NA NA hsa-let-7a-3p PRICKLE2 1.42015538786275 7.03375209382654e-13 -2.50492561876767 7.67759900282699e-16 mirMAP -0.539207780568871 8.89168214926097e-13 NA NA NA hsa-let-7b-3p PRICKLE2 0.868207752019623 1.30460056774366e-05 -2.50492561876767 7.67759900282699e-16 mirMAP -0.328335792282048 2.4936781253752e-05 NA NA NA hsa-let-7f-1-3p PRICKLE2 1.55054488387679 7.31326775537952e-11 -2.50492561876767 7.67759900282699e-16 mirMAP -0.244778321291301 0.000208801132478198 NA NA NA hsa-miR-10b-3p PRICKLE2 0.77597971642517 0.00264877454133753 -2.50492561876767 7.67759900282699e-16 mirMAP -0.336029709578612 1.70612906836132e-08 NA NA NA hsa-miR-130b-5p PRICKLE2 2.9963110846538 1.98883029416455e-18 -2.50492561876767 7.67759900282699e-16 mirMAP -0.418794308513175 8.87186562840989e-23 NA NA NA hsa-miR-148a-3p PRICKLE2 1.26728238710376 2.52325607402829e-06 -2.50492561876767 7.67759900282699e-16 MirTarget;miRNATAP -0.183463168162059 0.00138399519884756 NA NA NA hsa-miR-148a-5p PRICKLE2 1.16173838132242 0.000148929299881612 -2.50492561876767 7.67759900282699e-16 mirMAP -0.200810568471398 6.77574524096079e-05 NA NA NA hsa-miR-148b-3p PRICKLE2 1.97815018171325 6.07715327281595e-26 -2.50492561876767 7.67759900282699e-16 MirTarget;miRNATAP -0.785948003844471 3.4941229577441e-26 NA NA NA hsa-miR-15b-3p PRICKLE2 2.33847028227712 4.29662877950836e-19 -2.50492561876767 7.67759900282699e-16 mirMAP -0.628334141188587 1.70338531742982e-32 NA NA NA hsa-miR-16-2-3p PRICKLE2 2.31623086727196 4.29838149388188e-20 -2.50492561876767 7.67759900282699e-16 mirMAP -0.62986755142219 3.39607505724523e-30 NA NA NA hsa-miR-181a-2-3p PRICKLE2 2.19062681262366 3.81790102612782e-13 -2.50492561876767 7.67759900282699e-16 MirTarget -0.341307067912297 3.67551574898414e-12 NA NA NA hsa-miR-181a-5p PRICKLE2 2.29556023480783 1.8138457900616e-21 -2.50492561876767 7.67759900282699e-16 mirMAP;miRNATAP -0.306150029056787 5.47331855122461e-07 NA NA NA hsa-miR-181b-5p PRICKLE2 2.49307679431293 3.92829250217627e-20 -2.50492561876767 7.67759900282699e-16 mirMAP;miRNATAP -0.306972546968241 1.49605086429176e-08 NA NA NA hsa-miR-181c-5p PRICKLE2 1.58587920618301 1.57506918816933e-10 -2.50492561876767 7.67759900282699e-16 mirMAP;miRNATAP -0.248094060481048 5.49615515048076e-05 NA NA NA hsa-miR-182-5p PRICKLE2 3.53923166221814 5.07781258121574e-21 -2.50492561876767 7.67759900282699e-16 MirTarget -0.402997008407211 1.15936336737611e-27 NA NA NA hsa-miR-186-5p PRICKLE2 1.47445398888668 3.0781726595413e-15 -2.50492561876767 7.67759900282699e-16 MirTarget -0.647366335276188 1.98790215551895e-16 NA NA NA hsa-miR-18a-5p PRICKLE2 3.78535678765353 3.72446596213886e-26 -2.50492561876767 7.67759900282699e-16 MirTarget -0.397503888220548 4.73287579586341e-22 NA NA NA hsa-miR-194-5p PRICKLE2 1.8992998339217 3.76507853301977e-10 -2.50492561876767 7.67759900282699e-16 miRNATAP -0.332545564558026 1.55955134652075e-11 NA NA NA hsa-miR-197-3p PRICKLE2 1.75733174019505 8.88576793100499e-13 -2.50492561876767 7.67759900282699e-16 mirMAP -0.523811308936105 1.30426908928557e-18 NA NA NA hsa-miR-19a-3p PRICKLE2 3.42309334186656 3.02671914353412e-28 -2.50492561876767 7.67759900282699e-16 MirTarget;miRNATAP -0.448020028810871 7.15751272213005e-24 NA NA NA hsa-miR-19b-3p PRICKLE2 2.49529833021187 1.57028265846699e-23 -2.50492561876767 7.67759900282699e-16 MirTarget;miRNATAP -0.583853366206712 1.70592670236508e-25 NA NA NA hsa-miR-21-5p PRICKLE2 2.73773305747971 1.38864982139576e-43 -2.50492561876767 7.67759900282699e-16 miRNAWalker2_validate;MirTarget -0.32154392485735 5.80431134032331e-06 NA NA NA hsa-miR-26a-2-3p PRICKLE2 0.823520019989974 0.00017092160823769 -2.50492561876767 7.67759900282699e-16 mirMAP -0.207327015381524 0.00381163515579496 NA NA NA hsa-miR-27a-3p PRICKLE2 1.66542180327138 4.93775737894805e-13 -2.50492561876767 7.67759900282699e-16 MirTarget;miRNATAP -0.266909584000749 5.00424020408607e-05 NA NA NA hsa-miR-29b-2-5p PRICKLE2 0.910668640983475 0.00666655585493488 -2.50492561876767 7.67759900282699e-16 MirTarget -0.254304829321332 2.7924017902013e-08 NA NA NA hsa-miR-29b-3p PRICKLE2 1.65828197923813 1.02676780888141e-09 -2.50492561876767 7.67759900282699e-16 MirTarget;miRNATAP -0.29455478993929 1.28845300253223e-07 NA NA NA hsa-miR-3065-5p PRICKLE2 2.74629919868982 1.86846589298284e-08 -2.50492561876767 7.67759900282699e-16 mirMAP -0.219991659143872 6.30210971625527e-09 NA NA NA hsa-miR-32-3p PRICKLE2 2.02436999565685 5.94091197945307e-09 -2.50492561876767 7.67759900282699e-16 MirTarget;mirMAP -0.41999543628016 3.4862581324979e-18 NA NA NA hsa-miR-320a PRICKLE2 0.438165828017084 0.0390159073347133 -2.50492561876767 7.67759900282699e-16 mirMAP -0.339242707665728 3.8402629388289e-06 NA NA NA hsa-miR-320b PRICKLE2 1.55692969039548 1.41071034251915e-08 -2.50492561876767 7.67759900282699e-16 mirMAP -0.411686480520056 3.85537610846259e-14 NA NA NA hsa-miR-330-3p PRICKLE2 0.876747334239085 0.00073709016089703 -2.50492561876767 7.67759900282699e-16 MirTarget -0.333568983374932 1.69001575512376e-08 NA NA NA hsa-miR-330-5p PRICKLE2 1.15100069700871 4.85551805046014e-07 -2.50492561876767 7.67759900282699e-16 miRanda;miRNATAP -0.405437403051796 1.12063713986028e-09 NA NA NA hsa-miR-335-3p PRICKLE2 3.08791651139852 5.31309869723517e-12 -2.50492561876767 7.67759900282699e-16 mirMAP -0.221986046390664 2.12174175529857e-11 NA NA NA hsa-miR-335-5p PRICKLE2 1.77247705492746 2.22457658872091e-06 -2.50492561876767 7.67759900282699e-16 miRNAWalker2_validate -0.222604983866899 4.17758779886941e-08 NA NA NA hsa-miR-33a-3p PRICKLE2 1.72765312072219 1.51784443453521e-07 -2.50492561876767 7.67759900282699e-16 mirMAP -0.384866357837623 1.19918403955929e-14 NA NA NA hsa-miR-33a-5p PRICKLE2 3.79671563098419 1.15966309820345e-18 -2.50492561876767 7.67759900282699e-16 MirTarget -0.389559001780461 2.99838847240645e-28 NA NA NA hsa-miR-361-5p PRICKLE2 0.971859117235239 5.30236555707088e-09 -2.50492561876767 7.67759900282699e-16 MirTarget;PITA;miRanda;miRNATAP -0.720946809339488 1.62609363058102e-15 NA NA NA hsa-miR-362-5p PRICKLE2 1.59303749908759 9.582675908797e-08 -2.50492561876767 7.67759900282699e-16 mirMAP -0.23331159541905 5.06381816673275e-06 NA NA NA hsa-miR-374a-3p PRICKLE2 0.533309330504947 0.00192918429705142 -2.50492561876767 7.67759900282699e-16 MirTarget;miRNATAP -0.464429679965743 3.07399534922093e-07 NA NA NA hsa-miR-421 PRICKLE2 1.17791565395543 6.78526676976629e-06 -2.50492561876767 7.67759900282699e-16 miRanda -0.36305743489363 4.65091550666742e-10 NA NA NA hsa-miR-429 PRICKLE2 4.48815175680773 2.44117492218206e-17 -2.50492561876767 7.67759900282699e-16 miRNATAP -0.269451585547536 6.25050578589781e-24 NA NA NA hsa-miR-450b-5p PRICKLE2 1.69244418548325 1.68064054148881e-10 -2.50492561876767 7.67759900282699e-16 MirTarget;mirMAP;miRNATAP -0.173958479332406 0.00258337415018424 NA NA NA hsa-miR-484 PRICKLE2 1.81844463411787 1.82951571230938e-15 -2.50492561876767 7.67759900282699e-16 miRNATAP -0.606447560779501 6.86854418780793e-22 NA NA NA hsa-miR-500a-5p PRICKLE2 1.72110365584658 3.0807246212659e-10 -2.50492561876767 7.67759900282699e-16 mirMAP -0.25441235799491 4.7917325770782e-06 NA NA NA hsa-miR-576-5p PRICKLE2 2.20467023993664 3.4053475193793e-19 -2.50492561876767 7.67759900282699e-16 mirMAP -0.488017551727603 9.30335022190535e-17 NA NA NA hsa-miR-589-3p PRICKLE2 2.51971841868825 2.39125940264107e-11 -2.50492561876767 7.67759900282699e-16 MirTarget -0.312234425882489 3.45417826036575e-12 NA NA NA hsa-miR-589-5p PRICKLE2 1.71990116752371 8.310889042056e-14 -2.50492561876767 7.67759900282699e-16 MirTarget;miRNATAP -0.487305559975744 2.99464301103798e-14 NA NA NA hsa-miR-590-3p PRICKLE2 2.59289455139753 1.03200520972022e-21 -2.50492561876767 7.67759900282699e-16 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.505549166522866 5.61908122712949e-21 NA NA NA hsa-miR-590-5p PRICKLE2 3.18300989862077 2.06813568597893e-26 -2.50492561876767 7.67759900282699e-16 MirTarget;PITA;miRanda -0.484977141849688 2.22683032544822e-24 NA NA NA hsa-miR-592 PRICKLE2 1.51765968871077 0.000636335248013204 -2.50492561876767 7.67759900282699e-16 mirMAP -0.21180118717848 1.36017774928397e-09 NA NA NA hsa-miR-624-5p PRICKLE2 1.47043111118159 8.25080691741182e-09 -2.50492561876767 7.67759900282699e-16 mirMAP -0.387758298962577 2.8636467142759e-10 NA NA NA hsa-miR-628-5p PRICKLE2 0.799263053510813 2.28892357418044e-05 -2.50492561876767 7.67759900282699e-16 PITA;miRNATAP -0.319429805077997 0.000110570682635733 NA NA NA hsa-miR-629-3p PRICKLE2 2.36570947321815 1.33458201201618e-11 -2.50492561876767 7.67759900282699e-16 MirTarget -0.329679846764565 7.23182440667344e-12 NA NA NA hsa-miR-664a-3p PRICKLE2 0.634721925861133 0.00520070178640421 -2.50492561876767 7.67759900282699e-16 mirMAP -0.271811407401018 7.41456668436614e-05 NA NA NA hsa-miR-664a-5p PRICKLE2 0.505019913598436 0.032933350691651 -2.50492561876767 7.67759900282699e-16 MirTarget -0.202569193130537 0.00227148622765962 NA NA NA hsa-miR-7-1-3p PRICKLE2 1.84950311431067 1.25300363397654e-13 -2.50492561876767 7.67759900282699e-16 MirTarget -0.55473523939828 1.1301405644128e-21 NA NA NA hsa-miR-944 PRICKLE2 2.91186649218281 1.31574753528144e-06 -2.50492561876767 7.67759900282699e-16 PITA;miRNATAP -0.184288294285594 7.60723612439939e-13 NA NA NA hsa-let-7a-3p PRKACB 1.42015538786275 7.03375209382654e-13 -1.11910356116881 7.24897707751757e-07 MirTarget;mirMAP;miRNATAP -0.21962130459547 5.79651670137419e-05 NA NA NA hsa-let-7b-3p PRKACB 0.868207752019623 1.30460056774366e-05 -1.11910356116881 7.24897707751757e-07 MirTarget;mirMAP;miRNATAP -0.185130585565506 0.000844018426388941 NA NA NA hsa-let-7d-3p PRKACB 0.837345596411224 1.39469480391458e-05 -1.11910356116881 7.24897707751757e-07 MirTarget -0.193122206370836 0.000761987397647901 NA NA NA hsa-let-7f-1-3p PRKACB 1.55054488387679 7.31326775537952e-11 -1.11910356116881 7.24897707751757e-07 MirTarget;mirMAP -0.13342047017702 0.00451064067873152 NA NA NA hsa-miR-126-5p PRKACB 0.895338176458417 2.33372756450713e-05 -1.11910356116881 7.24897707751757e-07 mirMAP -0.171245788041164 0.00102349617124601 NA NA NA hsa-miR-141-3p PRKACB 5.02396127982626 2.19224509139725e-24 -1.11910356116881 7.24897707751757e-07 MirTarget;TargetScan;miRNATAP -0.131248917259806 2.40182503281301e-10 NA NA NA hsa-miR-16-2-3p PRKACB 2.31623086727196 4.29838149388188e-20 -1.11910356116881 7.24897707751757e-07 mirMAP -0.211513116774948 3.56654687944943e-07 NA NA NA hsa-miR-17-5p PRKACB 3.2710598467455 9.93128340539455e-27 -1.11910356116881 7.24897707751757e-07 TargetScan -0.195594044734934 5.04690942157379e-09 NA NA NA hsa-miR-182-5p PRKACB 3.53923166221814 5.07781258121574e-21 -1.11910356116881 7.24897707751757e-07 MirTarget;miRNATAP -0.141282769334308 3.27226662914892e-07 NA NA NA hsa-miR-183-5p PRKACB 4.19757025992371 4.79612296318304e-26 -1.11910356116881 7.24897707751757e-07 MirTarget -0.132170429294976 3.08274590025093e-07 NA NA NA hsa-miR-18a-5p PRKACB 3.78535678765353 3.72446596213886e-26 -1.11910356116881 7.24897707751757e-07 miRNATAP -0.170312158994311 1.8268780409686e-08 NA NA NA hsa-miR-193a-3p PRKACB 1.60460546928078 2.86169793322984e-07 -1.11910356116881 7.24897707751757e-07 miRanda -0.185097829574766 8.14913568795542e-08 NA NA NA hsa-miR-19a-3p PRKACB 3.42309334186656 3.02671914353412e-28 -1.11910356116881 7.24897707751757e-07 MirTarget;miRNATAP -0.217127685863828 2.72225260525319e-11 NA NA NA hsa-miR-19b-3p PRKACB 2.49529833021187 1.57028265846699e-23 -1.11910356116881 7.24897707751757e-07 miRNAWalker2_validate;MirTarget;miRNATAP -0.267352556269149 9.00420806048956e-11 NA NA NA hsa-miR-200c-3p PRKACB 3.50132673580082 2.42716349086937e-15 -1.11910356116881 7.24897707751757e-07 MirTarget;miRNATAP -0.125201076382777 1.50017445380767e-07 NA NA NA hsa-miR-2110 PRKACB 1.16625590651194 6.4784195289885e-05 -1.11910356116881 7.24897707751757e-07 MirTarget -0.106141262528439 0.00882154187258127 NA NA NA hsa-miR-3065-5p PRKACB 2.74629919868982 1.86846589298284e-08 -1.11910356116881 7.24897707751757e-07 MirTarget -0.103807774563958 0.000132862723321062 NA NA NA hsa-miR-30d-3p PRKACB 0.977747550180601 4.3048212205381e-05 -1.11910356116881 7.24897707751757e-07 mirMAP -0.230639716646997 4.57613056559806e-07 NA NA NA hsa-miR-32-3p PRKACB 2.02436999565685 5.94091197945307e-09 -1.11910356116881 7.24897707751757e-07 mirMAP;miRNATAP -0.100714992594509 0.00471640544853458 NA NA NA hsa-miR-339-5p PRKACB 2.68710938429893 3.03134080808154e-16 -1.11910356116881 7.24897707751757e-07 miRanda -0.145165623596419 6.50854523117634e-06 NA NA NA hsa-miR-34a-5p PRKACB 1.9016323452565 1.43092834643601e-14 -1.11910356116881 7.24897707751757e-07 miRNATAP -0.238915288481547 2.59419071561778e-08 NA NA NA hsa-miR-361-5p PRKACB 0.971859117235239 5.30236555707088e-09 -1.11910356116881 7.24897707751757e-07 miRanda -0.178114095699739 0.00724869450353386 NA NA NA hsa-miR-362-3p PRKACB 2.0756816987665 3.89026064579331e-12 -1.11910356116881 7.24897707751757e-07 PITA;miRanda;miRNATAP -0.2320492729467 2.29661541166603e-10 NA NA NA hsa-miR-362-5p PRKACB 1.59303749908759 9.582675908797e-08 -1.11910356116881 7.24897707751757e-07 PITA -0.194987590184185 6.59081906609811e-08 NA NA NA hsa-miR-3653-3p PRKACB 1.85886928622326 2.98407490336841e-08 -1.11910356116881 7.24897707751757e-07 MirTarget -0.105612181380441 0.00210192398606289 NA NA NA hsa-miR-532-5p PRKACB 1.55697650978597 1.57884735535196e-11 -1.11910356116881 7.24897707751757e-07 PITA -0.27784223940084 1.83614058183971e-09 NA NA NA hsa-miR-590-3p PRKACB 2.59289455139753 1.03200520972022e-21 -1.11910356116881 7.24897707751757e-07 MirTarget;PITA;miRanda;miRNATAP -0.20137371596257 3.58630956215221e-07 NA NA NA hsa-miR-590-5p PRKACB 3.18300989862077 2.06813568597893e-26 -1.11910356116881 7.24897707751757e-07 miRanda -0.22361088291547 1.69108646897883e-10 NA NA NA hsa-miR-7-1-3p PRKACB 1.84950311431067 1.25300363397654e-13 -1.11910356116881 7.24897707751757e-07 mirMAP -0.160819398581311 0.000186176032630634 NA NA NA hsa-miR-708-3p PRKACB 2.80907765282502 3.07460722669281e-14 -1.11910356116881 7.24897707751757e-07 mirMAP -0.107628106192083 0.000190951072862047 NA NA NA hsa-miR-93-5p PRKACB 3.03961860136032 1.11672209617395e-24 -1.11910356116881 7.24897707751757e-07 miRNAWalker2_validate -0.194608106414379 2.15593790853491e-08 NA NA NA hsa-miR-96-5p PRKACB 4.89433085814374 1.92000659886961e-31 -1.11910356116881 7.24897707751757e-07 miRNATAP -0.144257226112366 5.04306410867738e-09 NA NA NA hsa-miR-142-5p PRKCA 1.17581605694506 0.0018174701991234 -1.04253532292201 0.000330447904822586 mirMAP -0.155281859758494 2.83714874751982e-05 NA NA NA hsa-miR-146a-5p PRKCA 1.19829319599115 0.00157081974524452 -1.04253532292201 0.000330447904822586 mirMAP -0.131710886401928 0.000370553312736514 NA NA NA hsa-miR-146b-5p PRKCA 1.75587235896724 1.15724631266659e-07 -1.04253532292201 0.000330447904822586 mirMAP -0.178218054737334 2.01234944480139e-05 NA NA NA hsa-miR-150-5p PRKCA -0.105827294491332 0.799351458244375 -1.04253532292201 0.000330447904822586 mirMAP -0.124697814540873 0.00022848052592286 NA NA NA hsa-miR-17-3p PRKCA 2.2704817679209 1.1667437320211e-22 -1.04253532292201 0.000330447904822586 miRNAWalker2_validate -0.163389027302081 0.00492702694664717 NA NA NA hsa-miR-181a-5p PRKCA 2.29556023480783 1.8138457900616e-21 -1.04253532292201 0.000330447904822586 mirMAP -0.332076264197257 1.58885695452918e-09 NA NA NA hsa-miR-181b-5p PRKCA 2.49307679431293 3.92829250217627e-20 -1.04253532292201 0.000330447904822586 mirMAP -0.255352495229191 2.20407502467148e-07 NA NA NA hsa-miR-181c-5p PRKCA 1.58587920618301 1.57506918816933e-10 -1.04253532292201 0.000330447904822586 mirMAP -0.187181736198993 0.000814130560426752 NA NA NA hsa-miR-183-5p PRKCA 4.19757025992371 4.79612296318304e-26 -1.04253532292201 0.000330447904822586 miRNATAP -0.167765439348368 3.7027196892035e-07 NA NA NA hsa-miR-186-5p PRKCA 1.47445398888668 3.0781726595413e-15 -1.04253532292201 0.000330447904822586 miRNATAP -0.372737117584225 3.41129073481267e-07 NA NA NA hsa-miR-193b-3p PRKCA 2.25711804611899 4.1940744806631e-14 -1.04253532292201 0.000330447904822586 miRNAWalker2_validate -0.184015097403191 5.6276271806172e-05 NA NA NA hsa-miR-193b-5p PRKCA 1.59567208918739 4.89398272459427e-08 -1.04253532292201 0.000330447904822586 mirMAP -0.144499830970602 0.00240910945358069 NA NA NA hsa-miR-1976 PRKCA 2.06550563678192 7.81396978619772e-18 -1.04253532292201 0.000330447904822586 miRNATAP -0.17995688234711 0.00150164194068263 NA NA NA hsa-miR-19b-1-5p PRKCA 2.57951428759379 4.31576118703427e-20 -1.04253532292201 0.000330447904822586 mirMAP -0.172921934994649 0.000451924002079924 NA NA NA hsa-miR-200b-3p PRKCA 3.78235093249346 3.18343003239465e-14 -1.04253532292201 0.000330447904822586 TargetScan -0.114961109829389 2.45352651543255e-05 NA NA NA hsa-miR-200c-3p PRKCA 3.50132673580082 2.42716349086937e-15 -1.04253532292201 0.000330447904822586 miRNATAP -0.158977004957444 1.80034178057763e-07 NA NA NA hsa-miR-214-3p PRKCA -0.176344800034733 0.642485503428886 -1.04253532292201 0.000330447904822586 mirMAP -0.126245731078837 0.000711043186976772 NA NA NA hsa-miR-22-5p PRKCA 1.88011544159252 1.63978222572222e-16 -1.04253532292201 0.000330447904822586 mirMAP -0.258621101167742 1.45994385651039e-05 NA NA NA hsa-miR-24-2-5p PRKCA 2.07171035460647 3.15853539996136e-16 -1.04253532292201 0.000330447904822586 miRNAWalker2_validate -0.190869345201713 0.000384051796932142 22911661 Preferential star strand biogenesis of pre miR 24 2 targets PKC alpha and suppresses cell survival in MCF 7 breast cancer cells poor survival breast cancer hsa-miR-339-5p PRKCA 2.68710938429893 3.03134080808154e-16 -1.04253532292201 0.000330447904822586 mirMAP -0.146901538113986 0.000377758588526939 NA NA NA hsa-miR-3607-3p PRKCA 2.68532138541128 5.66716351955047e-14 -1.04253532292201 0.000330447904822586 mirMAP -0.141547181715678 0.000312501141538225 NA NA NA hsa-miR-362-5p PRKCA 1.59303749908759 9.582675908797e-08 -1.04253532292201 0.000330447904822586 TargetScan;miRNATAP -0.155938176693359 0.000821123203239911 NA NA NA hsa-miR-369-3p PRKCA 0.946781510019564 0.00134850306966842 -1.04253532292201 0.000330447904822586 PITA;miRNATAP -0.153415665611504 0.0013232753592926 NA NA NA hsa-miR-381-3p PRKCA -0.0821432056113931 0.752465205603634 -1.04253532292201 0.000330447904822586 mirMAP -0.182718955463403 0.000792478176257635 NA NA NA hsa-miR-429 PRKCA 4.48815175680773 2.44117492218206e-17 -1.04253532292201 0.000330447904822586 miRanda;miRNATAP -0.108496235247986 1.950717922572e-05 NA NA NA hsa-miR-450b-5p PRKCA 1.69244418548325 1.68064054148881e-10 -1.04253532292201 0.000330447904822586 PITA;mirMAP;miRNATAP -0.164559118659435 0.00164963824183995 NA NA NA hsa-miR-500a-5p PRKCA 1.72110365584658 3.0807246212659e-10 -1.04253532292201 0.000330447904822586 miRNATAP -0.224298470556856 8.73025451195054e-06 NA NA NA hsa-miR-501-5p PRKCA 1.93654809410041 1.3779381780759e-10 -1.04253532292201 0.000330447904822586 miRNATAP -0.160491119587112 0.000665161220237392 NA NA NA hsa-miR-505-3p PRKCA 1.45322244209148 8.86597629645867e-10 -1.04253532292201 0.000330447904822586 miRNAWalker2_validate -0.17319300539973 0.00317185860747904 NA NA NA hsa-miR-505-5p PRKCA 1.89243395287645 9.82003586561819e-12 -1.04253532292201 0.000330447904822586 mirMAP -0.170760296141889 0.000583545058780229 NA NA NA hsa-miR-532-3p PRKCA 1.96631878320218 4.53421954361695e-13 -1.04253532292201 0.000330447904822586 mirMAP;miRNATAP -0.153994961004655 0.00236643084778704 NA NA NA hsa-miR-590-3p PRKCA 2.59289455139753 1.03200520972022e-21 -1.04253532292201 0.000330447904822586 PITA;miRanda;mirMAP;miRNATAP -0.257692443896068 3.43649017566933e-07 NA NA NA hsa-miR-92a-3p PRKCA 2.06460102658973 1.44784291084757e-19 -1.04253532292201 0.000330447904822586 miRNAWalker2_validate -0.177264968474978 0.0028853007950597 NA NA NA hsa-miR-93-3p PRKCA 2.85383869771942 5.64481766902125e-23 -1.04253532292201 0.000330447904822586 mirMAP -0.164593044407034 0.000371570157401047 NA NA NA hsa-miR-129-5p PRKCB -0.524170159980738 0.222582956006346 -3.26032077132529 1.38524824909011e-12 miRanda;mirMAP -0.174875281711081 0.00126377112961492 NA NA NA hsa-miR-141-5p PRKCB 3.81419396518882 3.21977359736126e-18 -3.26032077132529 1.38524824909011e-12 mirMAP -0.448157631252767 6.03056466923945e-21 NA NA NA hsa-miR-16-2-3p PRKCB 2.31623086727196 4.29838149388188e-20 -3.26032077132529 1.38524824909011e-12 mirMAP -0.508156111029493 2.858696818642e-09 NA NA NA hsa-miR-186-5p PRKCB 1.47445398888668 3.0781726595413e-15 -3.26032077132529 1.38524824909011e-12 mirMAP -0.79180135498475 1.36020814670637e-11 NA NA NA hsa-miR-194-5p PRKCB 1.8992998339217 3.76507853301977e-10 -3.26032077132529 1.38524824909011e-12 miRNATAP -0.485081827287577 2.16525492854143e-11 NA NA NA hsa-miR-200b-3p PRKCB 3.78235093249346 3.18343003239465e-14 -3.26032077132529 1.38524824909011e-12 MirTarget -0.450279840251611 3.58923445938153e-27 NA NA NA hsa-miR-200c-3p PRKCB 3.50132673580082 2.42716349086937e-15 -3.26032077132529 1.38524824909011e-12 MirTarget;miRNATAP -0.48715771688849 5.01263551249731e-25 NA NA NA hsa-miR-23a-3p PRKCB 1.00493340843378 2.55313889288924e-08 -3.26032077132529 1.38524824909011e-12 mirMAP -0.422834753714352 0.000810959402297788 NA NA NA hsa-miR-24-3p PRKCB 0.99989036772428 1.35595013650376e-07 -3.26032077132529 1.38524824909011e-12 miRNATAP -0.496540154032259 3.34685620532722e-05 NA NA NA hsa-miR-26b-5p PRKCB 0.885393662798425 3.2116297961629e-06 -3.26032077132529 1.38524824909011e-12 mirMAP -0.316938073060502 0.0085744560045255 NA NA NA hsa-miR-29b-2-5p PRKCB 0.910668640983475 0.00666655585493488 -3.26032077132529 1.38524824909011e-12 mirMAP -0.34510237827648 3.08410596869229e-07 NA NA NA hsa-miR-30b-5p PRKCB 0.800822374912712 0.000133601914525413 -3.26032077132529 1.38524824909011e-12 mirMAP -0.425134820547528 9.53655468608799e-05 NA NA NA hsa-miR-30c-5p PRKCB 0.778774633108 0.000285599212429136 -3.26032077132529 1.38524824909011e-12 mirMAP -0.468954366973799 1.00031056614682e-05 NA NA NA hsa-miR-30d-3p PRKCB 0.977747550180601 4.3048212205381e-05 -3.26032077132529 1.38524824909011e-12 mirMAP -0.529262539307465 2.03079793114812e-08 NA NA NA hsa-miR-30d-5p PRKCB 0.675423997639582 0.00270618816039773 -3.26032077132529 1.38524824909011e-12 mirMAP -0.603674275615055 1.78624617709124e-09 NA NA NA hsa-miR-330-5p PRKCB 1.15100069700871 4.85551805046014e-07 -3.26032077132529 1.38524824909011e-12 miRanda -0.265696306996962 0.00757029049385514 NA NA NA hsa-miR-335-3p PRKCB 3.08791651139852 5.31309869723517e-12 -3.26032077132529 1.38524824909011e-12 mirMAP -0.330098295724148 1.15037296640229e-11 NA NA NA hsa-miR-335-5p PRKCB 1.77247705492746 2.22457658872091e-06 -3.26032077132529 1.38524824909011e-12 mirMAP -0.231797522536577 0.000116559468268159 NA NA NA hsa-miR-3607-3p PRKCB 2.68532138541128 5.66716351955047e-14 -3.26032077132529 1.38524824909011e-12 miRNATAP -0.309871089079837 9.51108883796167e-07 NA NA NA hsa-miR-361-5p PRKCB 0.971859117235239 5.30236555707088e-09 -3.26032077132529 1.38524824909011e-12 MirTarget;miRanda;miRNATAP -1.08630383105364 2.58179254217249e-16 NA NA NA hsa-miR-429 PRKCB 4.48815175680773 2.44117492218206e-17 -3.26032077132529 1.38524824909011e-12 MirTarget;miRanda;miRNATAP -0.42521096062837 6.46582126393278e-28 NA NA NA hsa-miR-450b-5p PRKCB 1.69244418548325 1.68064054148881e-10 -3.26032077132529 1.38524824909011e-12 miRNATAP -0.300053601902219 0.00039020696289519 NA NA NA hsa-miR-452-3p PRKCB 2.42521958420768 4.08754552781156e-07 -3.26032077132529 1.38524824909011e-12 mirMAP -0.174939955360914 0.000207028768427815 NA NA NA hsa-miR-484 PRKCB 1.81844463411787 1.82951571230938e-15 -3.26032077132529 1.38524824909011e-12 MirTarget;miRNATAP -0.703163397284051 1.07982697132474e-13 NA NA NA hsa-miR-491-5p PRKCB 0.615770352820862 0.0418295628761654 -3.26032077132529 1.38524824909011e-12 miRanda -0.381404660757775 2.20068611106109e-06 NA NA NA hsa-miR-589-3p PRKCB 2.51971841868825 2.39125940264107e-11 -3.26032077132529 1.38524824909011e-12 mirMAP -0.452218517865859 7.06052991667871e-12 NA NA NA hsa-miR-589-5p PRKCB 1.71990116752371 8.310889042056e-14 -3.26032077132529 1.38524824909011e-12 mirMAP -0.544486942502154 1.22125132593852e-08 NA NA NA hsa-miR-590-3p PRKCB 2.59289455139753 1.03200520972022e-21 -3.26032077132529 1.38524824909011e-12 mirMAP -0.388404821887359 2.22817064825303e-06 NA NA NA hsa-miR-590-5p PRKCB 3.18300989862077 2.06813568597893e-26 -3.26032077132529 1.38524824909011e-12 miRanda -0.553979313426607 1.10231423603006e-14 NA NA NA hsa-miR-7-1-3p PRKCB 1.84950311431067 1.25300363397654e-13 -3.26032077132529 1.38524824909011e-12 mirMAP -0.468511892026853 1.14425525890782e-07 NA NA NA hsa-miR-7-5p PRKCB 2.28980165299999 1.5131097560452e-07 -3.26032077132529 1.38524824909011e-12 MirTarget;miRNATAP -0.171892302839442 0.00201428643670522 NA NA NA hsa-miR-944 PRKCB 2.91186649218281 1.31574753528144e-06 -3.26032077132529 1.38524824909011e-12 mirMAP -0.173419280691746 6.46731956750453e-06 NA NA NA hsa-miR-374b-5p RAC1 0.0654362503857184 0.722673188879465 0.221936454340431 0.051549220692643 mirMAP -0.101573831955509 0.000746852128506454 NA NA NA hsa-miR-375 RAC2 1.13910305294079 0.0512283522214186 0.0225400305534329 0.947191555182511 miRanda -0.111974015284125 5.98476138848745e-05 NA NA NA hsa-miR-361-5p RHOA 0.971859117235239 5.30236555707088e-09 -0.230748867704724 0.030592243709878 MirTarget;PITA;miRanda -0.164727125115389 5.91440692337907e-08 NA NA NA hsa-let-7a-3p ROCK1 1.42015538786275 7.03375209382654e-13 -1.02661670614902 1.94754524728051e-09 MirTarget -0.16003331936042 0.000120540876738803 NA NA NA hsa-let-7g-3p ROCK1 3.26398061402445 3.96263126107645e-25 -1.02661670614902 1.94754524728051e-09 MirTarget -0.15581302459487 8.95130786544619e-10 NA NA NA hsa-miR-107 ROCK1 1.30977326593435 1.30372468603965e-11 -1.02661670614902 1.94754524728051e-09 miRanda -0.119087364388625 0.00550312830212256 NA NA NA hsa-miR-126-5p ROCK1 0.895338176458417 2.33372756450713e-05 -1.02661670614902 1.94754524728051e-09 mirMAP -0.172464120027516 1.27104399703317e-05 27108693 MicroRNA 126 inhibits tumor cell invasion and metastasis by downregulating ROCK1 in renal cell carcinoma metastasis kidney renal cell cancer hsa-miR-148b-3p ROCK1 1.97815018171325 6.07715327281595e-26 -1.02661670614902 1.94754524728051e-09 miRNAWalker2_validate -0.279081182346667 2.14015194986577e-11 NA NA NA hsa-miR-16-1-3p ROCK1 2.56983217111073 3.02262181237943e-20 -1.02661670614902 1.94754524728051e-09 MirTarget -0.207917435482076 6.59320429139509e-13 NA NA NA hsa-miR-182-5p ROCK1 3.53923166221814 5.07781258121574e-21 -1.02661670614902 1.94754524728051e-09 MirTarget -0.129367164013929 6.18056517206253e-10 NA NA NA hsa-miR-190a-5p ROCK1 0.762748400660219 0.0035950590410453 -1.02661670614902 1.94754524728051e-09 MirTarget -0.112852694205429 0.000456951035558202 NA NA NA hsa-miR-196b-5p ROCK1 1.71646270856386 4.37735885910369e-09 -1.02661670614902 1.94754524728051e-09 MirTarget -0.105631135385179 0.000182173962330639 NA NA NA hsa-miR-199b-5p ROCK1 0.218704279044827 0.519493319158441 -1.02661670614902 1.94754524728051e-09 miRanda -0.105786266749066 1.83517740907298e-05 NA NA NA hsa-miR-320a ROCK1 0.438165828017084 0.0390159073347133 -1.02661670614902 1.94754524728051e-09 miRanda -0.23831134413994 1.32756646387868e-09 NA NA NA hsa-miR-320b ROCK1 1.55692969039548 1.41071034251915e-08 -1.02661670614902 1.94754524728051e-09 miRanda -0.159130778995994 1.01124713873982e-07 NA NA NA hsa-miR-324-5p ROCK1 2.95683728155095 1.32960514360912e-20 -1.02661670614902 1.94754524728051e-09 MirTarget;PITA;miRanda -0.118431313766168 2.2910613914641e-06 NA NA NA hsa-miR-582-5p ROCK1 0.609226359812689 0.032988717891497 -1.02661670614902 1.94754524728051e-09 PITA -0.11645225372736 7.38340442690333e-05 NA NA NA hsa-miR-664a-3p ROCK1 0.634721925861133 0.00520070178640421 -1.02661670614902 1.94754524728051e-09 mirMAP -0.244809843386458 1.76957821323578e-11 NA NA NA hsa-let-7a-3p ROCK2 1.42015538786275 7.03375209382654e-13 -1.27631616742797 8.42580604068128e-07 mirMAP -0.210808918216694 0.000797703640371582 NA NA NA hsa-miR-126-5p ROCK2 0.895338176458417 2.33372756450713e-05 -1.27631616742797 8.42580604068128e-07 mirMAP -0.189029821054627 0.00159176807510824 NA NA NA hsa-miR-127-5p ROCK2 1.19850695520181 4.10976607177645e-05 -1.27631616742797 8.42580604068128e-07 PITA -0.147350589855343 0.000623699318629899 NA NA NA hsa-miR-142-3p ROCK2 2.75247908790621 1.45636065474764e-12 -1.27631616742797 8.42580604068128e-07 PITA;miRanda;miRNATAP -0.106911050458868 0.000733555550863697 NA NA NA hsa-miR-17-5p ROCK2 3.2710598467455 9.93128340539455e-27 -1.27631616742797 8.42580604068128e-07 TargetScan -0.215326836171022 2.16038147723404e-08 NA NA NA hsa-miR-3607-3p ROCK2 2.68532138541128 5.66716351955047e-14 -1.27631616742797 8.42580604068128e-07 mirMAP -0.182162248755882 1.90545088147527e-07 NA NA NA hsa-miR-369-3p ROCK2 0.946781510019564 0.00134850306966842 -1.27631616742797 8.42580604068128e-07 PITA -0.129098178306128 0.00264599376211178 NA NA NA hsa-miR-500a-5p ROCK2 1.72110365584658 3.0807246212659e-10 -1.27631616742797 8.42580604068128e-07 mirMAP -0.154970725822778 0.000663866430657911 NA NA NA hsa-miR-539-5p ROCK2 0.95216780650456 0.00284373332122135 -1.27631616742797 8.42580604068128e-07 mirMAP -0.115978170349612 0.00365972634311164 NA NA NA hsa-miR-582-5p ROCK2 0.609226359812689 0.032988717891497 -1.27631616742797 8.42580604068128e-07 mirMAP -0.134198928299352 0.00253763920219959 NA NA NA hsa-miR-589-3p ROCK2 2.51971841868825 2.39125940264107e-11 -1.27631616742797 8.42580604068128e-07 mirMAP -0.122788727749752 0.0010074207494257 NA NA NA hsa-miR-590-3p ROCK2 2.59289455139753 1.03200520972022e-21 -1.27631616742797 8.42580604068128e-07 miRanda;mirMAP -0.185591580714152 4.79951683893355e-05 NA NA NA hsa-miR-1301-3p SFRP1 2.54959518791507 5.26618591274892e-18 -4.72165743596444 1.94213340952985e-11 MirTarget -0.929647366224829 2.27335164851971e-17 NA NA NA hsa-miR-144-3p SFRP1 0.658119849508907 0.146943823997989 -4.72165743596444 1.94213340952985e-11 MirTarget;miRNATAP -0.307330683826125 0.000100475665353503 NA NA NA hsa-miR-16-1-3p SFRP1 2.56983217111073 3.02262181237943e-20 -4.72165743596444 1.94213340952985e-11 MirTarget -0.991671709293944 6.59532238581082e-17 NA NA NA hsa-miR-182-5p SFRP1 3.53923166221814 5.07781258121574e-21 -4.72165743596444 1.94213340952985e-11 mirMAP -0.689760445961909 6.52748321080623e-16 NA NA NA hsa-miR-19b-1-5p SFRP1 2.57951428759379 4.31576118703427e-20 -4.72165743596444 1.94213340952985e-11 MirTarget -0.808788841622436 1.27899660304967e-11 NA NA NA hsa-miR-203a-3p SFRP1 3.12352008343999 9.49391438647189e-07 -4.72165743596444 1.94213340952985e-11 MirTarget -0.206110439303078 0.000125185210743585 NA NA NA hsa-miR-26b-3p SFRP1 2.18464160365372 2.11543189388328e-18 -4.72165743596444 1.94213340952985e-11 MirTarget -1.1751124326119 7.4696422523186e-20 NA NA NA hsa-miR-27a-3p SFRP1 1.66542180327138 4.93775737894805e-13 -4.72165743596444 1.94213340952985e-11 MirTarget;miRNATAP -0.517297481926742 0.000463587731630782 NA NA NA hsa-miR-30d-3p SFRP1 0.977747550180601 4.3048212205381e-05 -4.72165743596444 1.94213340952985e-11 miRNATAP -0.812619782319965 1.61238813761418e-08 NA NA NA hsa-miR-328-3p SFRP1 0.596804159297544 0.013858523511843 -4.72165743596444 1.94213340952985e-11 MirTarget -0.806049045586438 1.52940471916615e-08 NA NA NA hsa-miR-33a-3p SFRP1 1.72765312072219 1.51784443453521e-07 -4.72165743596444 1.94213340952985e-11 MirTarget -0.829475588580487 1.30601007666134e-13 NA NA NA hsa-miR-429 SFRP1 4.48815175680773 2.44117492218206e-17 -4.72165743596444 1.94213340952985e-11 miRNATAP -0.527828848274553 3.5454964050295e-18 NA NA NA hsa-miR-484 SFRP1 1.81844463411787 1.82951571230938e-15 -4.72165743596444 1.94213340952985e-11 MirTarget -0.997642924789862 5.9055489271025e-12 NA NA NA hsa-miR-501-5p SFRP1 1.93654809410041 1.3779381780759e-10 -4.72165743596444 1.94213340952985e-11 mirMAP -0.479591960160584 3.64262607664923e-05 NA NA NA hsa-miR-576-5p SFRP1 2.20467023993664 3.4053475193793e-19 -4.72165743596444 1.94213340952985e-11 MirTarget;PITA -0.995471337489543 5.60062584414907e-14 NA NA NA hsa-miR-625-5p SFRP1 1.42540152147292 1.95797147911206e-06 -4.72165743596444 1.94213340952985e-11 MirTarget -0.49096169965567 0.000101372757547789 NA NA NA hsa-miR-7-1-3p SFRP1 1.84950311431067 1.25300363397654e-13 -4.72165743596444 1.94213340952985e-11 MirTarget;mirMAP -0.762107203560682 1.43537728973781e-08 NA NA NA hsa-miR-940 SFRP1 3.21011374578759 2.7923171128495e-14 -4.72165743596444 1.94213340952985e-11 MirTarget -0.686367126934405 4.68712399228061e-16 NA NA NA hsa-miR-96-5p SFRP1 4.89433085814374 1.92000659886961e-31 -4.72165743596444 1.94213340952985e-11 mirMAP -0.669139763083358 1.28798090621278e-18 NA NA NA hsa-let-7a-3p SFRP2 1.42015538786275 7.03375209382654e-13 -4.16178735068602 3.31506527735546e-05 miRNATAP -0.89281914791746 0.000227340302932607 NA NA NA hsa-miR-129-5p SFRP2 -0.524170159980738 0.222582956006346 -4.16178735068602 3.31506527735546e-05 miRanda -0.630160932622878 3.86233153372382e-08 NA NA NA hsa-miR-33a-3p SFRP2 1.72765312072219 1.51784443453521e-07 -4.16178735068602 3.31506527735546e-05 miRNATAP -1.62705268702629 7.92231939632561e-27 NA NA NA hsa-miR-421 SFRP2 1.17791565395543 6.78526676976629e-06 -4.16178735068602 3.31506527735546e-05 miRanda -1.01500630773474 3.39180166966394e-08 NA NA NA hsa-miR-582-5p SFRP2 0.609226359812689 0.032988717891497 -4.16178735068602 3.31506527735546e-05 miRNATAP -1.18412195898295 1.52956890812353e-12 NA NA NA hsa-miR-590-3p SFRP2 2.59289455139753 1.03200520972022e-21 -4.16178735068602 3.31506527735546e-05 miRanda -0.97105911982824 2.69858165021412e-08 NA NA NA hsa-miR-129-5p SFRP4 -0.524170159980738 0.222582956006346 -1.41812614850623 0.144139876921528 miRanda -0.637222711825178 6.50533571239219e-09 NA NA NA hsa-miR-135b-5p SFRP4 3.62510365056501 1.09148980810091e-10 -1.41812614850623 0.144139876921528 MirTarget -0.400250647773767 3.11844917971521e-06 NA NA NA hsa-miR-144-5p SFRP4 0.195856574290527 0.61856475838049 -1.41812614850623 0.144139876921528 MirTarget -0.941974526813176 3.50144316140929e-16 NA NA NA hsa-miR-26b-5p SFRP4 0.885393662798425 3.2116297961629e-06 -1.41812614850623 0.144139876921528 miRNAWalker2_validate -1.21337911678089 7.24653678773283e-07 NA NA NA hsa-miR-3607-3p SFRP4 2.68532138541128 5.66716351955047e-14 -1.41812614850623 0.144139876921528 MirTarget -0.849736907270799 3.45388748105254e-11 NA NA NA hsa-miR-375 SFRP4 1.13910305294079 0.0512283522214186 -1.41812614850623 0.144139876921528 miRanda -0.337279266167069 2.30235054354617e-05 NA NA NA hsa-miR-429 SFRP4 4.48815175680773 2.44117492218206e-17 -1.41812614850623 0.144139876921528 miRanda -0.661619050561664 8.57873647657987e-16 NA NA NA hsa-miR-532-5p SFRP4 1.55697650978597 1.57884735535196e-11 -1.41812614850623 0.144139876921528 MirTarget -0.931213634256187 2.56628880190551e-06 NA NA NA hsa-miR-664a-3p SFRP4 0.634721925861133 0.00520070178640421 -1.41812614850623 0.144139876921528 mirMAP -1.03890413731503 4.31949530349031e-07 NA NA NA hsa-miR-944 SFRP4 2.91186649218281 1.31574753528144e-06 -1.41812614850623 0.144139876921528 mirMAP -0.536101827755114 5.07239766557947e-12 NA NA NA hsa-miR-339-5p SFRP5 2.68710938429893 3.03134080808154e-16 -4.00418767619732 1.33283270821635e-12 miRanda -0.426709848250993 1.63047977022509e-07 NA NA NA hsa-miR-181a-5p SMAD2 2.29556023480783 1.8138457900616e-21 -0.217872679367038 0.049686680004959 mirMAP -0.112519930018506 7.12492899365623e-08 24394555 Here we show that miR-181a promotes TGF-β-mediated epithelial-to-mesenchymal transition via repression of its functional target Smad7 miR-181a and phosphorylated Smad2 are enriched in recurrent compared with matched-primary ovarian tumours and their expression is associated with shorter time to recurrence and poor outcome in patients with EOC recurrence ovarian cancer hsa-miR-181b-5p SMAD2 2.49307679431293 3.92829250217627e-20 -0.217872679367038 0.049686680004959 mirMAP -0.102985568847665 2.98550912982442e-08 NA NA NA hsa-miR-26a-5p SMAD2 0.0464832722967259 0.752628386912329 -0.217872679367038 0.049686680004959 mirMAP -0.11130754251612 0.0026935683249941 NA NA NA hsa-miR-361-3p SMAD2 1.07367425434318 1.73142774168958e-09 -0.217872679367038 0.049686680004959 miRNATAP -0.114638945395339 0.000110242156000821 22675530 Functional analyses showed that Smad2 and TGFß1 are not dysregulated by miR-361-3p and miR-625* in the lung cell line A549 respectively lung cancer hsa-let-7a-2-3p SMAD3 0.0400317820791161 0.91528727576685 -0.145068391221315 0.569239559252949 mirMAP -0.127624470471724 0.000115244641159406 NA NA NA hsa-miR-125b-2-3p SMAD3 -1.83175829351767 2.94917958974528e-05 -0.145068391221315 0.569239559252949 mirMAP -0.167358601156691 2.00437048846808e-09 NA NA NA hsa-miR-127-5p SMAD3 1.19850695520181 4.10976607177645e-05 -0.145068391221315 0.569239559252949 mirMAP -0.175774439508378 2.40422906256706e-05 NA NA NA hsa-miR-132-3p SMAD3 0.156276992635384 0.408190812100704 -0.145068391221315 0.569239559252949 mirMAP -0.307625427852275 2.61092084929535e-06 NA NA NA hsa-miR-142-5p SMAD3 1.17581605694506 0.0018174701991234 -0.145068391221315 0.569239559252949 PITA -0.121783193917905 0.000168543842540946 NA NA NA hsa-miR-145-5p SMAD3 -1.55259331973517 9.97889123247165e-07 -0.145068391221315 0.569239559252949 MirTarget;miRNATAP -0.102333497957109 0.0076425159078547 27237033 MiR 145 and miR 203 represses TGF β induced epithelial mesenchymal transition and invasion by inhibiting SMAD3 in non small cell lung cancer cells; siRNA-mediated knockdown of SMAD3 copied the phenotype of miR-145 and miR-203 overexpression in A549 and 95C cells; MiR-145 and miR-203 inhibited TGF-β-induced EMT and invasion through repression of SMAD3 in NSCLC cells lung squamous cell cancer hsa-miR-155-5p SMAD3 1.20164021433135 0.00086170622431261 -0.145068391221315 0.569239559252949 miRNAWalker2_validate -0.167586664196246 6.20173080978562e-07 27626488 Here we demonstrated that TGF-β1 elevated the expression of miR-155 in colorectal cancer cells through SMAD3 and SMAD4 colorectal cancer hsa-miR-188-5p SMAD3 2.52825126596644 6.78099435999778e-14 -0.145068391221315 0.569239559252949 PITA -0.184950370967834 7.35063541952032e-07 NA NA NA hsa-miR-18a-5p SMAD3 3.78535678765353 3.72446596213886e-26 -0.145068391221315 0.569239559252949 miRNAWalker2_validate -0.136878014915373 5.63544047470077e-05 23249750 The unexpected effects of miR-18a on CTGF transcription are mediated in part by direct targeting of Smad3 and ensuing weakening of TGFβ signaling glioblastoma hsa-miR-195-5p SMAD3 -1.44753678070504 8.70594292149271e-09 -0.145068391221315 0.569239559252949 MirTarget -0.155082880098317 0.00129697117488075 27206216 MiR 195 Suppresses Cervical Cancer Migration and Invasion Through Targeting Smad3; The purposes of this study were to investigate the role of miR-195 in cervical cancer and clarify the regulation of Smad3 by miR-195; Smad3 was verified as a direct target of miR-195 which was further confirmed by the inverse expression of miR-195 and Smad3 in patients' specimens cervical and endocervical cancer hsa-miR-212-3p SMAD3 0.357878936470387 0.232446214501331 -0.145068391221315 0.569239559252949 mirMAP -0.196270501722139 1.760966299711e-06 NA NA NA hsa-miR-326 SMAD3 0.715313016136042 0.0610265683213359 -0.145068391221315 0.569239559252949 miRanda -0.127854658986735 7.18944162313972e-05 NA NA NA hsa-miR-424-5p SMAD3 1.61930224569578 1.89642549274994e-10 -0.145068391221315 0.569239559252949 MirTarget -0.137637867799144 0.0037931514509118 27655675 miR 424 5p promotes proliferation of gastric cancer by targeting Smad3 through TGF β signaling pathway; QRT-PCR was used to determine the expression levels of miR-424-5p and Smad3; Luciferase reporter assay and western blotting were used to prove that Smad3 was one of the direct targets of miR-424-5p; In addition luciferase reporter assay and western blotting assay revealed that Smad3 was a direct target of miR-424-5p; Over-expression of Smad3 could partially reverse the effects of miR-424-5p on GC cell proliferation; Our study further revealed that miR-424-5p could inhibit TGF-β signaling pathway by Smad3 gastric cancer hsa-miR-485-3p SMAD3 0.442820096243914 0.166634696770945 -0.145068391221315 0.569239559252949 MirTarget -0.146973333951251 0.000145374061338494 NA NA NA hsa-miR-495-3p SMAD3 -0.0847115949846082 0.763475496144456 -0.145068391221315 0.569239559252949 mirMAP -0.147079833458788 0.000814867470605654 NA NA NA hsa-miR-497-5p SMAD3 0.0257087130056286 0.918145413833358 -0.145068391221315 0.569239559252949 MirTarget -0.149416186909323 0.00253073754447704 NA NA NA hsa-miR-501-5p SMAD3 1.93654809410041 1.3779381780759e-10 -0.145068391221315 0.569239559252949 mirMAP -0.178593095060563 1.2547872342843e-05 NA NA NA hsa-miR-589-3p SMAD3 2.51971841868825 2.39125940264107e-11 -0.145068391221315 0.569239559252949 mirMAP -0.112359264624293 0.0019298395243008 NA NA NA hsa-let-7f-1-3p SMAD4 1.55054488387679 7.31326775537952e-11 -0.586921155134023 3.52416916552263e-06 mirMAP -0.106405479232356 4.39371133743738e-05 NA NA NA hsa-miR-140-5p SMAD4 0.844753502512594 3.73722278438606e-05 -0.586921155134023 3.52416916552263e-06 miRanda -0.114517150132142 0.000134319769998401 NA NA NA hsa-miR-146b-5p SMAD4 1.75587235896724 1.15724631266659e-07 -0.586921155134023 3.52416916552263e-06 PITA;miRanda;miRNATAP -0.103959435086478 8.75874581151263e-09 21874046;26883911 MicroRNA miR 146b 5p regulates signal transduction of TGF β by repressing SMAD4 in thyroid cancer; A computational search revealed that miR-146b-5p putatively binds to the 3' untranslated region UTR of SMAD4 an important member of the transforming growth factor β TGF-β signaling pathway; Luciferase reporter assay confirmed the direct binding of miR-146b-5p on the SMAD4 3'UTR; Specific inhibition of miR-146b-5p with a locked nucleic acid-modified anti-miR-146b oligonucleotide significantly increased SMAD4 levels in the human papillary carcinoma cell lines TPC-1 and BCPAP; The overexpression of miR-146b-5p in normal rat follicular PCCL3 cells decreased SMAD4 levels and disrupted TGF-β signal transduction;The overexpression of SMAD4 in BCPAP cells a validated target of miR-146b-5p and key protein in the TGF-β signaling pathway inhibited migration similarly to the effects observed with the antagomiR 146b-5p ; thyroid cancer;thyroid cancer hsa-miR-186-5p SMAD4 1.47445398888668 3.0781726595413e-15 -0.586921155134023 3.52416916552263e-06 miRNAWalker2_validate;mirMAP -0.107040467643529 0.000873099593755318 NA NA NA hsa-miR-2355-5p SMAD4 1.32510310704724 8.25139516692683e-07 -0.586921155134023 3.52416916552263e-06 MirTarget -0.100237269384076 8.83439826066143e-06 NA NA NA hsa-miR-26b-5p SMAD4 0.885393662798425 3.2116297961629e-06 -0.586921155134023 3.52416916552263e-06 MirTarget;miRNATAP -0.101564603889141 0.00171580634002753 24890815 Overexpression of miR-26b also repressed Smad4 expression whereas its inhibition elevated Smad4 expression; In HCC cell lines miR-26b targeted the 3'UTR of USP9X which in turn affects EMT through Smad4 and the TGF-β signaling pathway liver cancer hsa-miR-27a-3p SMAD4 1.66542180327138 4.93775737894805e-13 -0.586921155134023 3.52416916552263e-06 MirTarget -0.13536279837513 1.62491622147447e-07 NA NA NA hsa-miR-34a-5p SMAD4 1.9016323452565 1.43092834643601e-14 -0.586921155134023 3.52416916552263e-06 miRNATAP -0.121709073519824 3.8975183335493e-07 22750848 Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network; Specifically in glioblastoma within the context of the global network promoter enrichment analysis of network edges uncovered a novel regulation of TGF-β signaling via a Smad4 transcriptomic network by miR-34a glioblastoma hsa-miR-362-3p SMAD4 2.0756816987665 3.89026064579331e-12 -0.586921155134023 3.52416916552263e-06 miRNATAP -0.105074125190041 3.2218791406447e-07 NA NA NA hsa-miR-576-5p SMAD4 2.20467023993664 3.4053475193793e-19 -0.586921155134023 3.52416916552263e-06 mirMAP -0.106133513564488 8.78863207489382e-06 NA NA NA hsa-miR-141-3p SOX17 5.02396127982626 2.19224509139725e-24 -2.94798887132292 6.52451561011194e-21 TargetScan -0.256726942553231 1.9475675823917e-18 22921431 Inhibition of SOX17 by microRNA 141 and methylation activates the WNT signaling pathway in esophageal cancer; MicroRNA 141 was also found to down-regulate SOX17 expression and activate the WNT signal pathway esophageal cancer hsa-miR-26b-5p SOX17 0.885393662798425 3.2116297961629e-06 -2.94798887132292 6.52451561011194e-21 miRNATAP -0.248054912544758 0.00315615311176464 NA NA NA hsa-miR-330-5p SOX17 1.15100069700871 4.85551805046014e-07 -2.94798887132292 6.52451561011194e-21 miRanda -0.30637343726308 8.69430797835861e-06 NA NA NA hsa-miR-362-3p SOX17 2.0756816987665 3.89026064579331e-12 -2.94798887132292 6.52451561011194e-21 miRanda;miRNATAP -0.141260036995058 0.00878893299297899 NA NA NA hsa-miR-421 SOX17 1.17791565395543 6.78526676976629e-06 -2.94798887132292 6.52451561011194e-21 miRanda -0.30262015358656 4.92995991235237e-07 NA NA NA hsa-miR-590-3p SOX17 2.59289455139753 1.03200520972022e-21 -2.94798887132292 6.52451561011194e-21 miRanda;miRNATAP -0.448317394761125 1.03655081728629e-15 NA NA NA hsa-miR-590-5p SOX17 3.18300989862077 2.06813568597893e-26 -2.94798887132292 6.52451561011194e-21 miRanda -0.408104262709017 2.5149436420718e-16 NA NA NA hsa-miR-103a-2-5p TBL1X 2.47599305985086 7.933028987326e-11 -1.42404908911917 3.94682830531495e-08 mirMAP -0.146741372827442 6.81686825615888e-05 NA NA NA hsa-miR-106b-5p TBL1X 2.46782146831112 1.36171495805632e-23 -1.42404908911917 3.94682830531495e-08 mirMAP;miRNATAP -0.140697597704805 0.00414179474339257 NA NA NA hsa-miR-142-3p TBL1X 2.75247908790621 1.45636065474764e-12 -1.42404908911917 3.94682830531495e-08 MirTarget;PITA;miRanda;miRNATAP -0.107622132046293 0.000708562852043506 NA NA NA hsa-miR-17-5p TBL1X 3.2710598467455 9.93128340539455e-27 -1.42404908911917 3.94682830531495e-08 TargetScan;mirMAP;miRNATAP -0.172846762278852 8.72658028539716e-06 NA NA NA hsa-miR-181a-5p TBL1X 2.29556023480783 1.8138457900616e-21 -1.42404908911917 3.94682830531495e-08 MirTarget;miRNATAP -0.275402493763871 3.15694988429066e-08 NA NA NA hsa-miR-181b-5p TBL1X 2.49307679431293 3.92829250217627e-20 -1.42404908911917 3.94682830531495e-08 MirTarget;miRNATAP -0.235101297024544 1.19234032411629e-07 NA NA NA hsa-miR-181c-5p TBL1X 1.58587920618301 1.57506918816933e-10 -1.42404908911917 3.94682830531495e-08 MirTarget;miRNATAP -0.162142725473055 0.00130464522337203 NA NA NA hsa-miR-185-5p TBL1X 2.34016206907488 1.17481626642022e-26 -1.42404908911917 3.94682830531495e-08 MirTarget -0.24833418114454 5.25590976771096e-06 NA NA NA hsa-miR-192-5p TBL1X 2.69002528723195 1.22990188194432e-16 -1.42404908911917 3.94682830531495e-08 miRNAWalker2_validate -0.108247863707839 0.00415879100078496 NA NA NA hsa-miR-19a-3p TBL1X 3.42309334186656 3.02671914353412e-28 -1.42404908911917 3.94682830531495e-08 mirMAP -0.153390013733524 5.8754590363073e-05 NA NA NA hsa-miR-19b-1-5p TBL1X 2.57951428759379 4.31576118703427e-20 -1.42404908911917 3.94682830531495e-08 mirMAP -0.183758729066053 3.37840896728338e-05 NA NA NA hsa-miR-19b-3p TBL1X 2.49529833021187 1.57028265846699e-23 -1.42404908911917 3.94682830531495e-08 mirMAP -0.196873238367411 4.44869346368907e-05 NA NA NA hsa-miR-20a-3p TBL1X 2.92621109947706 2.49504904635375e-17 -1.42404908911917 3.94682830531495e-08 MirTarget;miRNATAP -0.108764689447843 0.00279701642141533 NA NA NA hsa-miR-20a-5p TBL1X 3.15577933619191 4.19753346442454e-25 -1.42404908911917 3.94682830531495e-08 mirMAP;miRNATAP -0.172217554014665 1.0817574112091e-05 NA NA NA hsa-miR-22-5p TBL1X 1.88011544159252 1.63978222572222e-16 -1.42404908911917 3.94682830531495e-08 mirMAP -0.288124576027112 7.1029207235267e-08 NA NA NA hsa-miR-23a-3p TBL1X 1.00493340843378 2.55313889288924e-08 -1.42404908911917 3.94682830531495e-08 mirMAP -0.244761333413992 0.000489809026778358 NA NA NA hsa-miR-29b-1-5p TBL1X 1.55384379072167 4.76870585070176e-05 -1.42404908911917 3.94682830531495e-08 mirMAP -0.197418987607733 1.13610341458738e-08 NA NA NA hsa-miR-32-5p TBL1X 2.34056473219422 6.24134585974322e-20 -1.42404908911917 3.94682830531495e-08 mirMAP -0.12628544308395 0.00810145419984036 NA NA NA hsa-miR-3607-3p TBL1X 2.68532138541128 5.66716351955047e-14 -1.42404908911917 3.94682830531495e-08 MirTarget;miRNATAP -0.111713776514261 0.00163417423806164 NA NA NA hsa-miR-3614-5p TBL1X 2.17736331059655 2.19144831318484e-08 -1.42404908911917 3.94682830531495e-08 miRNATAP -0.157265795490723 1.95774784622873e-06 NA NA NA hsa-miR-362-3p TBL1X 2.0756816987665 3.89026064579331e-12 -1.42404908911917 3.94682830531495e-08 MirTarget;miRanda -0.13300990875811 0.00194515240547959 NA NA NA hsa-miR-484 TBL1X 1.81844463411787 1.82951571230938e-15 -1.42404908911917 3.94682830531495e-08 PITA -0.168099886585753 0.00187869895570408 NA NA NA hsa-miR-584-5p TBL1X 2.7326672683732 9.92677936962233e-12 -1.42404908911917 3.94682830531495e-08 mirMAP -0.124137867331392 5.44126862899439e-05 NA NA NA hsa-miR-589-3p TBL1X 2.51971841868825 2.39125940264107e-11 -1.42404908911917 3.94682830531495e-08 mirMAP -0.109368915400147 0.00357076609016757 NA NA NA hsa-miR-671-5p TBL1X 2.97733652243246 1.21148452344738e-23 -1.42404908911917 3.94682830531495e-08 MirTarget -0.187792428316735 1.07358059014233e-05 NA NA NA hsa-miR-92a-3p TBL1X 2.06460102658973 1.44784291084757e-19 -1.42404908911917 3.94682830531495e-08 miRNAWalker2_validate;mirMAP -0.160926984983059 0.00269515178135066 NA NA NA hsa-miR-93-5p TBL1X 3.03961860136032 1.11672209617395e-24 -1.42404908911917 3.94682830531495e-08 mirMAP;miRNATAP -0.11863101274335 0.0034632916273829 NA NA NA hsa-miR-96-5p TBL1X 4.89433085814374 1.92000659886961e-31 -1.42404908911917 3.94682830531495e-08 MirTarget;TargetScan -0.101124444201338 0.000444949458417605 NA NA NA hsa-miR-106a-5p TCF7L1 2.48882002962836 1.99757727374521e-12 -1.29563210038614 0.00022110689990566 MirTarget -0.237528555928573 3.23041076064227e-07 NA NA NA hsa-miR-106b-5p TCF7L1 2.46782146831112 1.36171495805632e-23 -1.29563210038614 0.00022110689990566 MirTarget -0.484981855840182 3.28026578455762e-14 NA NA NA hsa-miR-130b-5p TCF7L1 2.9963110846538 1.98883029416455e-18 -1.29563210038614 0.00022110689990566 MirTarget -0.271019550375905 2.2979535723062e-08 NA NA NA hsa-miR-141-3p TCF7L1 5.02396127982626 2.19224509139725e-24 -1.29563210038614 0.00022110689990566 miRNAWalker2_validate -0.292690799524826 5.33572896586791e-21 NA NA NA hsa-miR-15b-3p TCF7L1 2.33847028227712 4.29662877950836e-19 -1.29563210038614 0.00022110689990566 miRNATAP -0.300469437837364 1.27786211803164e-06 NA NA NA hsa-miR-17-5p TCF7L1 3.2710598467455 9.93128340539455e-27 -1.29563210038614 0.00022110689990566 MirTarget;TargetScan -0.232329734367548 8.28447631894401e-06 NA NA NA hsa-miR-185-3p TCF7L1 2.3922478518806 1.3373426768452e-14 -1.29563210038614 0.00022110689990566 MirTarget -0.264637899208463 5.26321085249236e-07 NA NA NA hsa-miR-200a-3p TCF7L1 4.59434485520731 6.38952518573476e-18 -1.29563210038614 0.00022110689990566 miRNAWalker2_validate -0.31712696382727 2.57417137844588e-28 NA NA NA hsa-miR-200b-3p TCF7L1 3.78235093249346 3.18343003239465e-14 -1.29563210038614 0.00022110689990566 miRNAWalker2_validate -0.344042033030514 1.2723812194927e-28 NA NA NA hsa-miR-200c-3p TCF7L1 3.50132673580082 2.42716349086937e-15 -1.29563210038614 0.00022110689990566 miRNAWalker2_validate -0.321512044267134 2.09544895880279e-19 NA NA NA hsa-miR-20a-5p TCF7L1 3.15577933619191 4.19753346442454e-25 -1.29563210038614 0.00022110689990566 MirTarget -0.255169684828929 1.08876064596683e-06 NA NA NA hsa-miR-20b-5p TCF7L1 2.07706563022469 1.10107236083433e-05 -1.29563210038614 0.00022110689990566 MirTarget -0.20708414684031 3.93831642070411e-09 NA NA NA hsa-miR-30b-3p TCF7L1 0.834142820354026 0.000972582820878813 -1.29563210038614 0.00022110689990566 MirTarget -0.334944599332039 6.20751141723943e-07 NA NA NA hsa-miR-30d-3p TCF7L1 0.977747550180601 4.3048212205381e-05 -1.29563210038614 0.00022110689990566 miRNATAP -0.376148637052463 9.58674800435899e-08 NA NA NA hsa-miR-330-5p TCF7L1 1.15100069700871 4.85551805046014e-07 -1.29563210038614 0.00022110689990566 miRanda -0.270812249528041 0.000249896592119458 NA NA NA hsa-miR-429 TCF7L1 4.48815175680773 2.44117492218206e-17 -1.29563210038614 0.00022110689990566 miRNAWalker2_validate -0.314442027101828 2.17867907624385e-27 NA NA NA hsa-miR-505-5p TCF7L1 1.89243395287645 9.82003586561819e-12 -1.29563210038614 0.00022110689990566 miRNATAP -0.254826466368037 2.03293000248315e-05 NA NA NA hsa-miR-590-3p TCF7L1 2.59289455139753 1.03200520972022e-21 -1.29563210038614 0.00022110689990566 PITA;miRanda;miRNATAP -0.231465745000028 0.000168980352397349 NA NA NA hsa-miR-93-5p TCF7L1 3.03961860136032 1.11672209617395e-24 -1.29563210038614 0.00022110689990566 MirTarget -0.400191107813803 3.80432743383064e-14 NA NA NA hsa-miR-155-5p TCF7L2 1.20164021433135 0.00086170622431261 -0.0989663661080726 0.582291209673574 MirTarget;miRNATAP -0.104003957059588 1.22170888051923e-05 NA NA NA hsa-miR-24-2-5p TCF7L2 2.07171035460647 3.15853539996136e-16 -0.0989663661080726 0.582291209673574 MirTarget -0.134437366020417 4.4418676957063e-05 NA NA NA hsa-miR-338-3p TCF7L2 0.453166438193782 0.144583389707558 -0.0989663661080726 0.582291209673574 miRanda -0.114047090229425 4.18397743027561e-05 NA NA NA hsa-miR-222-3p TP53 0.851783756239071 0.00266783568486918 0.17313275059387 0.48779406985331 miRNAWalker2_validate -0.116904656132339 0.00589565055970469 NA NA NA hsa-miR-139-5p VANGL1 -1.52606598644743 1.20474151350665e-08 0.483118014434106 0.00233637486055107 miRanda -0.117140872558099 3.18219054750645e-05 NA NA NA hsa-miR-218-5p VANGL1 -0.573801507392184 0.0551983860126703 0.483118014434106 0.00233637486055107 mirMAP -0.149209292230744 3.81021703549128e-09 NA NA NA hsa-miR-664a-3p VANGL1 0.634721925861133 0.00520070178640421 0.483118014434106 0.00233637486055107 mirMAP -0.162812632695059 1.32777362996694e-06 NA NA NA hsa-miR-146b-3p VANGL2 1.10569195233795 0.000660632782194023 0.111378318204013 0.81828911643189 PITA -0.188794440246072 0.00863891213403022 NA NA NA hsa-miR-30a-5p VANGL2 -0.878357906436456 0.000509952992366057 0.111378318204013 0.81828911643189 mirMAP -0.299676676106274 0.00119310667874316 NA NA NA hsa-miR-148b-3p WNT10B 1.97815018171325 6.07715327281595e-26 -1.27203222851497 0.00216255711887601 MirTarget -0.335932330151756 0.000961494889825557 NA NA NA hsa-miR-320a WNT10B 0.438165828017084 0.0390159073347133 -1.27203222851497 0.00216255711887601 miRanda -0.308659404441888 0.00123166210670891 NA NA NA hsa-miR-98-5p WNT10B 1.11154309866014 1.24143909012085e-08 -1.27203222851497 0.00216255711887601 miRNAWalker2_validate -0.428471972853677 2.63884478727919e-05 NA NA NA hsa-miR-320a WNT11 0.438165828017084 0.0390159073347133 -0.821017630142777 0.174343340060726 miRanda -0.419932472809252 0.00246805866460523 NA NA NA hsa-miR-330-3p WNT11 0.876747334239085 0.00073709016089703 -0.821017630142777 0.174343340060726 miRNATAP -0.630031523186883 1.32892882444745e-08 NA NA NA hsa-miR-429 WNT11 4.48815175680773 2.44117492218206e-17 -0.821017630142777 0.174343340060726 miRNATAP -0.323236245003944 4.91620754160683e-10 NA NA NA hsa-miR-139-5p WNT2 -1.52606598644743 1.20474151350665e-08 1.46246443466742 0.00687918143780108 miRanda -0.271811172089886 0.00495601435504474 NA NA NA hsa-miR-324-5p WNT2 2.95683728155095 1.32960514360912e-20 1.46246443466742 0.00687918143780108 miRanda -0.38757678515523 6.86691469936031e-07 NA NA NA hsa-miR-532-5p WNT2 1.55697650978597 1.57884735535196e-11 1.46246443466742 0.00687918143780108 miRNATAP -0.448940114207323 5.28040850028776e-05 NA NA NA hsa-miR-590-3p WNT2 2.59289455139753 1.03200520972022e-21 1.46246443466742 0.00687918143780108 miRanda;mirMAP -0.329847894616273 0.000497680240546934 NA NA NA hsa-miR-624-5p WNT2 1.47043111118159 8.25080691741182e-09 1.46246443466742 0.00687918143780108 MirTarget -0.373112640327464 0.000392477231594863 NA NA NA hsa-miR-944 WNT2 2.91186649218281 1.31574753528144e-06 1.46246443466742 0.00687918143780108 mirMAP -0.175095840465174 7.5128597488646e-05 NA NA NA hsa-miR-130a-3p WNT2B 2.02021855058359 1.26427102520415e-11 -2.76786035438807 3.62604310321995e-16 MirTarget -0.173292145162377 0.00189834360154361 NA NA NA hsa-miR-130b-3p WNT2B 3.5350292994509 1.73934183852569e-27 -2.76786035438807 3.62604310321995e-16 MirTarget -0.303083727967098 3.15414419909699e-10 NA NA NA hsa-miR-186-5p WNT2B 1.47445398888668 3.0781726595413e-15 -2.76786035438807 3.62604310321995e-16 mirMAP -0.526224059963912 1.96983492918001e-09 NA NA NA hsa-miR-301a-3p WNT2B 2.81024345929638 2.29784847962242e-17 -2.76786035438807 3.62604310321995e-16 MirTarget -0.287791209206809 2.43082847555678e-08 NA NA NA hsa-miR-32-3p WNT2B 2.02436999565685 5.94091197945307e-09 -2.76786035438807 3.62604310321995e-16 mirMAP -0.251790961985528 3.87936769691564e-06 NA NA NA hsa-miR-429 WNT2B 4.48815175680773 2.44117492218206e-17 -2.76786035438807 3.62604310321995e-16 miRNATAP -0.169581846338325 2.5079526239863e-08 NA NA NA hsa-miR-454-3p WNT2B 2.47234127820054 1.12878018736016e-21 -2.76786035438807 3.62604310321995e-16 MirTarget -0.41394177732075 6.39547989328164e-11 NA NA NA hsa-miR-576-5p WNT2B 2.20467023993664 3.4053475193793e-19 -2.76786035438807 3.62604310321995e-16 mirMAP -0.435613826545259 2.2340672726842e-11 NA NA NA hsa-miR-1-3p WNT3 -3.48370702447685 1.98579484008516e-13 2.12870130495657 9.36625720886595e-10 MirTarget -0.151819324676344 1.34289419213407e-05 NA NA NA hsa-miR-185-5p WNT5B 2.34016206907488 1.17481626642022e-26 -2.10977851058083 2.85645296158293e-05 miRNAWalker2_validate -0.60642348108017 6.66154666586742e-09 NA NA NA hsa-miR-28-5p WNT5B 0.230152919654905 0.0742909586754846 -2.10977851058083 2.85645296158293e-05 miRanda -0.530836498754109 0.00709692972406734 NA NA NA hsa-miR-339-5p WNT5B 2.68710938429893 3.03134080808154e-16 -2.10977851058083 2.85645296158293e-05 miRanda -0.219739518248835 0.00231584366935923 NA NA NA hsa-miR-15b-5p WNT7A 1.57112623124278 9.14247846750597e-13 1.48380060438584 0.0764894326083681 MirTarget -0.548908791209485 0.00235306455612105 27195958 WNT7A Regulation by miR 15b in Ovarian Cancer; In the present study we report that WNT7A is a direct target of miR-15b in ovarian cancer; We showed that a luciferase reporter containing the putative binding site of miR-15b in the WNT7A 3'-UTR was significantly repressed by miR-15b; Mutation of the putative binding site of miR-15b in the WNT7A 3'-UTR restored luciferase activity; Furthermore miR-15b was able to repress increased levels of TOPFLASH activity by WNT7A but not those induced by S33Y; Additionally miR-15b dose-dependently decreased WNT7A expression; When we evaluated the prognostic impact of WNT7A and miR-15b expression using TCGA datasets a significant inverse correlation in which high-expression of WNT7A and low-expression of miR-15b was associated with reduced survival rates of ovarian cancer patients; These results suggest that WNT7A is post-transcriptionally regulated by miR-15b which could be down-regulated by promoter hypermethylation potentially via DNMT1 in ovarian cancer poor survival ovarian cancer hsa-miR-361-5p WNT7A 0.971859117235239 5.30236555707088e-09 1.48380060438584 0.0764894326083681 MirTarget;PITA;miRanda -0.781472713576135 0.00129094368654843 NA NA NA hsa-miR-1226-3p WNT9A 1.38118928579963 0.000205503474787488 -2.06944914631955 1.31351479409276e-06 mirMAP -0.23306118890322 0.000261269579227027 NA NA NA hsa-miR-140-3p WNT9A 0.0608890720479334 0.727716871248724 -2.06944914631955 1.31351479409276e-06 mirMAP -0.579602489890684 1.58809164562323e-06 NA NA NA hsa-miR-148a-3p WNT9A 1.26728238710376 2.52325607402829e-06 -2.06944914631955 1.31351479409276e-06 mirMAP -0.270568023187923 0.00044238677321366 NA NA NA hsa-miR-148b-3p WNT9A 1.97815018171325 6.07715327281595e-26 -2.06944914631955 1.31351479409276e-06 mirMAP -0.797484051103519 8.69028922154765e-15 NA NA NA hsa-miR-15a-5p WNT9A 2.34669284378787 1.69544424500258e-23 -2.06944914631955 1.31351479409276e-06 mirMAP -0.523049603269295 3.33612355484908e-10 NA NA NA hsa-miR-15b-5p WNT9A 1.57112623124278 9.14247846750597e-13 -2.06944914631955 1.31351479409276e-06 mirMAP -0.537310487356042 4.9690416749748e-09 NA NA NA hsa-miR-16-5p WNT9A 1.75824877145857 1.68592440033108e-16 -2.06944914631955 1.31351479409276e-06 mirMAP -0.527507066701592 2.02103779015698e-08 NA NA NA hsa-miR-181a-2-3p WNT9A 2.19062681262366 3.81790102612782e-13 -2.06944914631955 1.31351479409276e-06 mirMAP -0.289021136203285 1.68823014050936e-05 NA NA NA hsa-miR-185-3p WNT9A 2.3922478518806 1.3373426768452e-14 -2.06944914631955 1.31351479409276e-06 mirMAP -0.317845522149715 9.19525985946639e-07 NA NA NA hsa-miR-193a-3p WNT9A 1.60460546928078 2.86169793322984e-07 -2.06944914631955 1.31351479409276e-06 mirMAP -0.220704468389379 0.000836909244150302 NA NA NA hsa-miR-22-3p WNT9A 1.21545661147757 1.61670170137775e-13 -2.06944914631955 1.31351479409276e-06 mirMAP -0.387232862036002 0.00200886957549209 NA NA NA hsa-miR-28-5p WNT9A 0.230152919654905 0.0742909586754846 -2.06944914631955 1.31351479409276e-06 mirMAP -0.499108130649814 0.00291674315897674 NA NA NA hsa-miR-32-5p WNT9A 2.34056473219422 6.24134585974322e-20 -2.06944914631955 1.31351479409276e-06 mirMAP -0.40706330365171 1.50628991198258e-07 NA NA NA hsa-miR-330-3p WNT9A 0.876747334239085 0.00073709016089703 -2.06944914631955 1.31351479409276e-06 mirMAP -0.253505316490192 0.0016392308187285 NA NA NA hsa-miR-331-3p WNT9A 2.28379581858927 1.99663919173155e-18 -2.06944914631955 1.31351479409276e-06 mirMAP -0.430796168913306 1.56673396070433e-08 NA NA NA hsa-miR-335-5p WNT9A 1.77247705492746 2.22457658872091e-06 -2.06944914631955 1.31351479409276e-06 miRNAWalker2_validate -0.215938135028036 8.72995417938918e-05 NA NA NA hsa-miR-363-3p WNT9A 1.50575300026701 0.00020976164678918 -2.06944914631955 1.31351479409276e-06 mirMAP -0.269097283647112 1.08413450909078e-07 NA NA NA hsa-miR-424-5p WNT9A 1.61930224569578 1.89642549274994e-10 -2.06944914631955 1.31351479409276e-06 mirMAP -0.335943130936018 3.02480044382518e-05 NA NA NA hsa-miR-532-3p WNT9A 1.96631878320218 4.53421954361695e-13 -2.06944914631955 1.31351479409276e-06 mirMAP -0.491322601879638 2.44328125497404e-11 NA NA NA hsa-miR-589-3p WNT9A 2.51971841868825 2.39125940264107e-11 -2.06944914631955 1.31351479409276e-06 mirMAP -0.320844220548304 1.47772350028815e-07 NA NA NA hsa-miR-708-5p WNT9A 3.38051631555486 5.12590198690777e-18 -2.06944914631955 1.31351479409276e-06 mirMAP -0.177570506962564 0.000533342150132389 NA NA NA hsa-miR-96-5p WNT9A 4.89433085814374 1.92000659886961e-31 -2.06944914631955 1.31351479409276e-06 mirMAP -0.222468024671624 2.30697971748039e-06 NA NA NA