miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-125b-5p AKT1 -1.94393269763542 2.78180543229264e-58 0.675644771423915 4.31393881321574e-23 miRNAWalker2_validate;miRTarBase -0.198341990959858 1.58124486218174e-28 NA NA NA hsa-miR-143-3p AKT1 -1.23248181631499 4.74160976678504e-28 0.675644771423915 4.31393881321574e-23 miRNAWalker2_validate -0.113351907486334 3.74647210660112e-08 NA NA NA hsa-miR-24-3p AKT2 -0.120123317289941 0.21432376743243 -0.0243409112523851 0.696831042278932 mirMAP -0.108581040434418 8.76204903485834e-07 NA NA NA hsa-miR-30e-3p AKT2 -0.708952170420973 1.05866470714978e-22 -0.0243409112523851 0.696831042278932 mirMAP -0.10769217628588 0.000202699653075448 NA NA NA hsa-miR-106b-5p AKT3 1.22477789913175 2.31787213143326e-32 -1.39153139819913 1.56022353185962e-23 miRNATAP -0.328917679851073 3.2761525214021e-13 NA NA NA hsa-miR-107 AKT3 0.678998026350662 2.56224148930538e-16 -1.39153139819913 1.56022353185962e-23 PITA;miRanda -0.322045444014362 3.05085750718847e-08 NA NA NA hsa-miR-15a-5p AKT3 0.812445324157528 4.50263417099822e-20 -1.39153139819913 1.56022353185962e-23 miRNAWalker2_validate;miRTarBase;miRNATAP -0.50537113863267 1.94212195956378e-21 NA NA NA hsa-miR-15b-5p AKT3 0.788659356634696 1.13678211092534e-11 -1.39153139819913 1.56022353185962e-23 miRNATAP -0.193152993862959 3.52162993117826e-06 NA NA NA hsa-miR-16-5p AKT3 0.46835991343556 1.91125356547776e-06 -1.39153139819913 1.56022353185962e-23 miRNAWalker2_validate;miRTarBase;miRNATAP -0.137142128931012 0.00593844300257035 NA NA NA hsa-miR-181a-5p AKT3 0.635863607630183 6.72486918157744e-11 -1.39153139819913 1.56022353185962e-23 miRNATAP -0.151700435123375 0.00241569058552761 NA NA NA hsa-miR-181b-5p AKT3 1.22749257795094 1.21998198830919e-27 -1.39153139819913 1.56022353185962e-23 miRNATAP -0.228362092376509 5.2632904676588e-08 NA NA NA hsa-miR-20a-5p AKT3 0.44979911120222 0.000602386964327228 -1.39153139819913 1.56022353185962e-23 miRNATAP -0.142287905559561 0.000137185408492637 NA NA NA hsa-miR-29b-2-5p AKT3 -0.263499971180298 0.0400001755611965 -1.39153139819913 1.56022353185962e-23 mirMAP -0.174192327083419 4.9828909918003e-06 NA NA NA hsa-miR-29b-3p AKT3 0.438847962603729 6.46722433236121e-05 -1.39153139819913 1.56022353185962e-23 miRNATAP -0.240095261108435 6.25012390753699e-08 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-29c-3p AKT3 -0.0652732378039769 0.563774115756922 -1.39153139819913 1.56022353185962e-23 miRNAWalker2_validate;miRNATAP -0.188130633733952 1.47230271027192e-05 NA NA NA hsa-miR-340-5p AKT3 1.0857159627596 4.94471062546756e-24 -1.39153139819913 1.56022353185962e-23 mirMAP -0.283834227072162 1.26866636163553e-10 NA NA NA hsa-miR-769-5p AKT3 0.564871766265874 8.16695101656941e-10 -1.39153139819913 1.56022353185962e-23 PITA;miRNATAP -0.188201328225218 0.000387633821142586 NA NA NA hsa-miR-93-5p AKT3 1.01788600209314 1.24312921618126e-21 -1.39153139819913 1.56022353185962e-23 miRNATAP -0.358774978428685 5.45504344144073e-16 NA NA NA hsa-let-7c-5p BCL2L1 -1.9415540533505 9.55250745007793e-48 0.522792065960586 7.61639356485872e-19 miRNAWalker2_validate;miRTarBase -0.128294871675362 1.88688918547409e-19 20347499 Over-expression of let-7c or let-7g led to a clear decrease of Bcl-xL expression in Huh7 and HepG2 cell lines; Reporter assays revealed direct post-transcriptional regulation involving let-7c or let-7g and the 3'-untranslated region of bcl-xl mRNA liver cancer hsa-let-7g-5p BCL2L1 0.0200025784917734 0.791635298815256 0.522792065960586 7.61639356485872e-19 miRNAWalker2_validate;miRTarBase;miRNATAP -0.126630887025706 3.82717679314587e-06 20347499 Over-expression of let-7c or let-7g led to a clear decrease of Bcl-xL expression in Huh7 and HepG2 cell lines; Reporter assays revealed direct post-transcriptional regulation involving let-7c or let-7g and the 3'-untranslated region of bcl-xl mRNA liver cancer hsa-let-7i-5p BCL2L1 -0.333419326258177 3.56960810786801e-08 0.522792065960586 7.61639356485872e-19 miRNATAP -0.321772345664847 8.06744439816135e-22 NA NA NA hsa-miR-140-5p BCL2L1 -0.755971041589807 9.68060922934542e-14 0.522792065960586 7.61639356485872e-19 PITA;miRanda;miRNATAP -0.178298678075701 1.10325405117987e-19 NA NA NA hsa-miR-505-5p BCL2L1 -0.842640534241897 4.43022473091907e-09 0.522792065960586 7.61639356485872e-19 miRNATAP -0.108734867438394 1.06030624737444e-14 NA NA NA hsa-miR-106b-5p CBL 1.22477789913175 2.31787213143326e-32 -0.680370172816626 1.00788843412567e-17 mirMAP -0.119838482900384 3.29833746550569e-06 NA NA NA hsa-miR-141-3p CBL 2.99777540204168 1.26370498493024e-78 -0.680370172816626 1.00788843412567e-17 MirTarget;TargetScan;mirMAP -0.115106125372554 1.1738554188593e-13 NA NA NA hsa-miR-181a-5p CBL 0.635863607630183 6.72486918157744e-11 -0.680370172816626 1.00788843412567e-17 mirMAP -0.175889973528059 3.40881473128203e-10 NA NA NA hsa-miR-181b-5p CBL 1.22749257795094 1.21998198830919e-27 -0.680370172816626 1.00788843412567e-17 mirMAP -0.161042161111585 8.8501950075918e-12 NA NA NA hsa-miR-200a-3p CBL 2.55218480823434 2.96135446816238e-51 -0.680370172816626 1.00788843412567e-17 MirTarget;mirMAP -0.106984119943656 2.26578579492675e-12 NA NA NA hsa-miR-200b-3p CBL 2.11744072703209 1.66710572104191e-43 -0.680370172816626 1.00788843412567e-17 MirTarget;TargetScan;mirMAP -0.118437584281099 2.87888645461771e-12 NA NA NA hsa-miR-200c-3p CBL 2.07038651806183 6.84613386286599e-51 -0.680370172816626 1.00788843412567e-17 MirTarget;mirMAP -0.136179026309206 2.63066757150576e-13 NA NA NA hsa-miR-21-5p CBL 2.32007501846389 3.08394781855554e-137 -0.680370172816626 1.00788843412567e-17 mirMAP -0.219435783158958 6.50717000138084e-19 NA NA NA hsa-miR-29c-3p CBL -0.0652732378039769 0.563774115756922 -0.680370172816626 1.00788843412567e-17 mirMAP -0.127336153124536 1.97905798272054e-07 NA NA NA hsa-miR-3913-5p CBL 0.71890413546147 2.61153227160465e-13 -0.680370172816626 1.00788843412567e-17 MirTarget;miRNATAP -0.184224770167968 2.84151860607535e-11 NA NA NA hsa-miR-429 CBL 2.84108892259147 3.88520896426515e-64 -0.680370172816626 1.00788843412567e-17 MirTarget;PITA;mirMAP;miRNATAP -0.102338931677859 1.46624742956126e-11 NA NA NA hsa-miR-542-3p CBL 0.568822103820889 8.5699075257651e-07 -0.680370172816626 1.00788843412567e-17 miRNATAP -0.111167856638321 3.0467106948747e-06 NA NA NA hsa-miR-30d-5p CBLB -0.247082219011045 0.00406717930063148 -0.298633921488533 1.96882492031575e-06 MirTarget;mirMAP -0.112665178114531 7.50424291475096e-06 NA NA NA hsa-let-7i-5p CCND1 -0.333419326258177 3.56960810786801e-08 0.789100261201456 1.48424202389562e-06 miRNATAP -0.759700962013673 2.31065071397228e-16 NA NA NA hsa-miR-106a-5p CCND1 0.574594373206545 0.000145868284001732 0.789100261201456 1.48424202389562e-06 MirTarget;miRNATAP -0.174359830876255 2.65007775906387e-06 NA NA NA hsa-miR-106b-5p CCND1 1.22477789913175 2.31787213143326e-32 0.789100261201456 1.48424202389562e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.258644062815507 8.24041501542474e-07 NA NA NA hsa-miR-142-3p CCND1 1.53951237846104 2.06769936282034e-17 0.789100261201456 1.48424202389562e-06 miRanda -0.111966511365121 0.000240262100008297 23619912 Transfection of miR-142-3p mimics in colon cancer cells downregulated cyclin D1 expression induced G1 phase cell cycle arrest and elevated the sensitivity of the cells to 5-fluorouracil colon cancer hsa-miR-142-5p CCND1 1.16509303143593 1.96641162209073e-13 0.789100261201456 1.48424202389562e-06 PITA -0.210173449112337 1.63510921192815e-09 NA NA NA hsa-miR-150-5p CCND1 -0.832049526091211 3.45299201139224e-05 0.789100261201456 1.48424202389562e-06 mirMAP -0.187252742453937 1.34917625164856e-11 NA NA NA hsa-miR-155-5p CCND1 1.09766314984151 4.55650930885814e-15 0.789100261201456 1.48424202389562e-06 miRNAWalker2_validate -0.298681895389198 2.32439253453393e-14 26955820 MicroRNA 155 expression inversely correlates with pathologic stage of gastric cancer and it inhibits gastric cancer cell growth by targeting cyclin D1 staging gastric cancer hsa-miR-15b-5p CCND1 0.788659356634696 1.13678211092534e-11 0.789100261201456 1.48424202389562e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.125463191460891 0.00921827566968511 NA NA NA hsa-miR-17-5p CCND1 0.599531757298529 1.07318660415906e-05 0.789100261201456 1.48424202389562e-06 miRNAWalker2_validate;MirTarget;TargetScan;miRNATAP -0.23795787679729 6.72139201694027e-09 26431674 Bioinformatics Prediction and In Vitro Analysis Revealed That miR 17 Targets Cyclin D1 mRNA in Triple Negative Breast Cancer Cells; In this study using bioinformatic analyses miR-17 was selected as it targets the 3'UTR of CCND1 gene with the highest score; After lentiviral transduction of miR-17 to the target cells gene expression analysis showed decreased expression of CCND1 gene breast cancer hsa-miR-186-5p CCND1 -0.426987301460247 1.04129380549315e-05 0.789100261201456 1.48424202389562e-06 mirMAP -0.494988902443749 5.18517439622754e-18 NA NA NA hsa-miR-19a-3p CCND1 0.817507952171848 3.76285090469625e-08 0.789100261201456 1.48424202389562e-06 miRNAWalker2_validate;miRTarBase;miRNATAP -0.216023850578105 8.24189814452405e-09 25985117 Moreover miR-19a might play inhibitory roles in HCC malignancy via regulating Cyclin D1 expression liver cancer hsa-miR-19b-1-5p CCND1 0.647704962003062 3.07687667945597e-07 0.789100261201456 1.48424202389562e-06 miRNAWalker2_validate;miRTarBase -0.206802040114629 3.03348057195458e-06 NA NA NA hsa-miR-19b-3p CCND1 0.139124391010031 0.255658553872934 0.789100261201456 1.48424202389562e-06 miRNATAP -0.249444343540709 5.93160032007176e-08 NA NA NA hsa-miR-20a-5p CCND1 0.44979911120222 0.000602386964327228 0.789100261201456 1.48424202389562e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.218045690926451 3.58399990050218e-07 NA NA NA hsa-miR-23b-3p CCND1 -0.363202401123049 0.000265305319764878 0.789100261201456 1.48424202389562e-06 miRNATAP -0.2085521275068 0.000237936656088415 NA NA NA hsa-miR-29a-3p CCND1 -0.699539666833076 1.13935003139957e-13 0.789100261201456 1.48424202389562e-06 mirMAP -0.358623457755512 1.12263469726765e-09 NA NA NA hsa-miR-340-5p CCND1 1.0857159627596 4.94471062546756e-24 0.789100261201456 1.48424202389562e-06 mirMAP -0.157803294541288 0.00210629660665075 NA NA NA hsa-miR-374a-5p CCND1 -0.239709888246804 0.00309819667153627 0.789100261201456 1.48424202389562e-06 MirTarget -0.556352001430099 7.67413515717595e-16 27191497 microRNA 374a suppresses colon cancer progression by directly reducing CCND1 to inactivate the PI3K/AKT pathway; Furthermore luciferase reporter assays confirmed that miR-374a could directly reduce CCND1; We examined miR-374a levels by in situ hybridization and its correlation with CCND1 expression in CRC tumor tissues; High miR-374a expression with low level of CCND1 was protective factor in CRC; Together these findings indicate that miR-374a inactivates the PI3K/AKT axis by inhibiting CCND1 suppressing of colon cancer progression progression colon cancer hsa-miR-374b-5p CCND1 -0.466781429946153 1.17238311619116e-08 0.789100261201456 1.48424202389562e-06 miRNAWalker2_validate;MirTarget -0.531193112029599 5.3445494840887e-15 NA NA NA hsa-miR-424-5p CCND1 0.420789584199235 0.00480101660479489 0.789100261201456 1.48424202389562e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.165346668007668 1.17175782770906e-05 NA NA NA hsa-miR-495-3p CCND1 -1.67685437612894 1.70634429769052e-34 0.789100261201456 1.48424202389562e-06 MirTarget -0.2655760978611 1.39010362325337e-11 NA NA NA hsa-miR-511-5p CCND1 -2.27545475897362 3.84085514050558e-36 0.789100261201456 1.48424202389562e-06 MirTarget -0.21938803198833 1.27831310404617e-13 NA NA NA hsa-miR-589-3p CCND1 0.0263457630961427 0.866577983997705 0.789100261201456 1.48424202389562e-06 MirTarget -0.116809863299678 0.00155105242627909 NA NA NA hsa-miR-590-3p CCND1 1.27438512890514 1.03164723481469e-23 0.789100261201456 1.48424202389562e-06 mirMAP -0.221641713536578 8.94498108920728e-07 NA NA NA hsa-miR-9-5p CCND1 0.734772328078424 0.00261982843636383 0.789100261201456 1.48424202389562e-06 miRNAWalker2_validate -0.162121975003827 1.12937727530253e-12 NA NA NA hsa-miR-92a-3p CCND1 -0.342420481092807 0.000732275969501111 0.789100261201456 1.48424202389562e-06 miRNAWalker2_validate -0.355039027931141 1.3665845638516e-10 NA NA NA hsa-miR-93-5p CCND1 1.01788600209314 1.24312921618126e-21 0.789100261201456 1.48424202389562e-06 miRNAWalker2_validate;MirTarget;miRNATAP -0.160469090487963 0.00197437840989499 NA NA NA hsa-miR-942-5p CCND1 0.0274758353801279 0.842368857038259 0.789100261201456 1.48424202389562e-06 MirTarget -0.261175156275166 1.39422778172566e-10 NA NA NA hsa-let-7a-3p CCND2 0.466622567891891 3.70886257943079e-07 -1.32381712777542 1.10807863083966e-33 mirMAP -0.215275364862757 3.63993039775257e-07 20418948 MicroRNA let 7a inhibits proliferation of human prostate cancer cells in vitro and in vivo by targeting E2F2 and CCND2 prostate cancer hsa-let-7e-5p CCND2 0.261471269338985 0.00191077095550257 -1.32381712777542 1.10807863083966e-33 miRNATAP -0.168033346737038 0.000309648297817392 NA NA NA hsa-miR-106a-5p CCND2 0.574594373206545 0.000145868284001732 -1.32381712777542 1.10807863083966e-33 miRNATAP -0.117204496646304 5.04333413242193e-06 NA NA NA hsa-miR-106b-5p CCND2 1.22477789913175 2.31787213143326e-32 -1.32381712777542 1.10807863083966e-33 miRNAWalker2_validate;miRTarBase;miRNATAP -0.324304654054346 9.75129599972944e-20 NA NA NA hsa-miR-130b-5p CCND2 1.0573161199584 2.55177349228739e-12 -1.32381712777542 1.10807863083966e-33 mirMAP -0.113060251982174 8.9777676148938e-06 NA NA NA hsa-miR-141-3p CCND2 2.99777540204168 1.26370498493024e-78 -1.32381712777542 1.10807863083966e-33 MirTarget;TargetScan -0.300723945575078 8.35441899721039e-47 NA NA NA hsa-miR-151a-3p CCND2 0.3530403796941 3.45015092968892e-05 -1.32381712777542 1.10807863083966e-33 mirMAP -0.17767569994557 0.000108302525662849 NA NA NA hsa-miR-15a-5p CCND2 0.812445324157528 4.50263417099822e-20 -1.32381712777542 1.10807863083966e-33 miRNAWalker2_validate;miRTarBase;miRNATAP -0.382989347535057 1.85935181542133e-19 NA NA NA hsa-miR-15b-5p CCND2 0.788659356634696 1.13678211092534e-11 -1.32381712777542 1.10807863083966e-33 miRNATAP -0.200863767053961 1.18885859507843e-09 NA NA NA hsa-miR-16-5p CCND2 0.46835991343556 1.91125356547776e-06 -1.32381712777542 1.10807863083966e-33 miRNAWalker2_validate;miRNATAP -0.126011969570663 0.00149555991801246 NA NA NA hsa-miR-17-5p CCND2 0.599531757298529 1.07318660415906e-05 -1.32381712777542 1.10807863083966e-33 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.218141508896336 9.56625930755479e-15 NA NA NA hsa-miR-182-5p CCND2 2.36408084103818 2.60011457600281e-72 -1.32381712777542 1.10807863083966e-33 miRNAWalker2_validate;miRTarBase;miRNATAP -0.333755066801542 7.98233999507297e-38 NA NA NA hsa-miR-183-5p CCND2 2.95681814393872 1.09965777344285e-92 -1.32381712777542 1.10807863083966e-33 miRNATAP -0.301857921065621 1.16754966176673e-39 NA NA NA hsa-miR-185-5p CCND2 0.482334746589337 3.68475879959415e-09 -1.32381712777542 1.10807863083966e-33 MirTarget;miRNATAP -0.252091965164496 1.07493887045353e-07 NA NA NA hsa-miR-191-5p CCND2 0.831652724468215 1.98847993606895e-12 -1.32381712777542 1.10807863083966e-33 MirTarget -0.190841372088135 4.05600831845751e-09 NA NA NA hsa-miR-19a-3p CCND2 0.817507952171848 3.76285090469625e-08 -1.32381712777542 1.10807863083966e-33 MirTarget;miRNATAP -0.185131062383478 6.94387115240903e-13 NA NA NA hsa-miR-19b-3p CCND2 0.139124391010031 0.255658553872934 -1.32381712777542 1.10807863083966e-33 miRNAWalker2_validate;MirTarget;miRNATAP -0.166767747836903 1.62862778749919e-07 NA NA NA hsa-miR-200a-3p CCND2 2.55218480823434 2.96135446816238e-51 -1.32381712777542 1.10807863083966e-33 MirTarget -0.261226562912324 4.31939405604759e-36 NA NA NA hsa-miR-20a-5p CCND2 0.44979911120222 0.000602386964327228 -1.32381712777542 1.10807863083966e-33 miRNAWalker2_validate;miRTarBase;miRNATAP -0.235095611327971 1.01223581717651e-15 NA NA NA hsa-miR-20b-5p CCND2 0.78236583455125 8.7938334801223e-05 -1.32381712777542 1.10807863083966e-33 miRNATAP -0.104708964184932 6.77204420924901e-08 NA NA NA hsa-miR-21-3p CCND2 2.17476065946878 5.15299442583591e-75 -1.32381712777542 1.10807863083966e-33 mirMAP -0.127404398971718 2.08059143790106e-05 NA NA NA hsa-miR-29b-3p CCND2 0.438847962603729 6.46722433236121e-05 -1.32381712777542 1.10807863083966e-33 MirTarget;miRNATAP -0.166630108966211 2.5453033344596e-06 22330340;24130168 In addition to CCND2 miR-29 also targets E2F7 another cell cycle regulator;We further demonstrated that miR-29 family acted as tumor suppressors through targeting CCND2 and matrix metalloproteinase-2 genes in GC ; sarcoma;gastric cancer hsa-miR-301a-3p CCND2 1.32170168375632 2.12280368957514e-15 -1.32381712777542 1.10807863083966e-33 miRNAWalker2_validate -0.182363632693643 1.4299291622836e-15 NA NA NA hsa-miR-3065-3p CCND2 1.62787885002468 6.81477830005026e-19 -1.32381712777542 1.10807863083966e-33 MirTarget;miRNATAP -0.215305118861858 1.68654607913855e-26 NA NA NA hsa-miR-30d-3p CCND2 0.264544633563642 0.00755023189129747 -1.32381712777542 1.10807863083966e-33 mirMAP -0.277305057640272 1.40644960106378e-12 NA NA NA hsa-miR-320b CCND2 0.412787504747938 0.00113457276903985 -1.32381712777542 1.10807863083966e-33 mirMAP;miRNATAP -0.105338094438455 0.000662995774848357 NA NA NA hsa-miR-324-3p CCND2 0.404877731996915 0.000340036423920834 -1.32381712777542 1.10807863083966e-33 miRNAWalker2_validate -0.187482582074807 4.91214943402943e-08 NA NA NA hsa-miR-331-5p CCND2 0.682437632502949 4.10871642662371e-11 -1.32381712777542 1.10807863083966e-33 miRNATAP -0.224823939820064 1.69348201302645e-09 NA NA NA hsa-miR-342-3p CCND2 1.21944481975657 6.81914373001202e-19 -1.32381712777542 1.10807863083966e-33 miRNAWalker2_validate;mirMAP -0.103848624831325 0.000189231379572542 NA NA NA hsa-miR-429 CCND2 2.84108892259147 3.88520896426515e-64 -1.32381712777542 1.10807863083966e-33 miRNATAP -0.232180070081619 1.04111918722712e-28 NA NA NA hsa-miR-590-3p CCND2 1.27438512890514 1.03164723481469e-23 -1.32381712777542 1.10807863083966e-33 miRanda;mirMAP -0.13833737728579 9.4871454586344e-06 NA NA NA hsa-miR-590-5p CCND2 0.746515607868274 8.51300479640125e-09 -1.32381712777542 1.10807863083966e-33 mirMAP -0.151134124586935 3.93710909950627e-07 NA NA NA hsa-miR-660-5p CCND2 0.406910761707485 0.000156175371762464 -1.32381712777542 1.10807863083966e-33 mirMAP -0.106401121539045 0.00339848496849202 NA NA NA hsa-miR-7-1-3p CCND2 0.686579567507582 1.20731554448806e-07 -1.32381712777542 1.10807863083966e-33 mirMAP -0.138929082076826 3.22847149980611e-06 NA NA NA hsa-miR-93-5p CCND2 1.01788600209314 1.24312921618126e-21 -1.32381712777542 1.10807863083966e-33 miRNATAP -0.400435186075896 5.37578279205249e-31 NA NA NA hsa-miR-96-5p CCND2 3.24596558166606 1.92296159041707e-98 -1.32381712777542 1.10807863083966e-33 TargetScan;miRNATAP -0.311897703713413 7.58506265459077e-49 NA NA NA hsa-miR-24-3p CISH -0.120123317289941 0.21432376743243 1.04779595144103 2.30541436250248e-15 MirTarget -0.453150045496669 3.14614604933452e-22 NA NA NA hsa-miR-324-5p CISH 0.211552647440779 0.139408130311654 1.04779595144103 2.30541436250248e-15 miRanda -0.228724068090635 6.84828428399846e-13 NA NA NA hsa-miR-361-5p CISH -0.0996867547900457 0.095428250126326 1.04779595144103 2.30541436250248e-15 miRanda -0.237157070688077 0.0025050150615093 NA NA NA hsa-miR-374a-3p CISH 0.34122393953022 2.28714105382856e-05 1.04779595144103 2.30541436250248e-15 MirTarget -0.22716170835534 7.4051677419992e-05 NA NA NA hsa-miR-30d-5p CLCF1 -0.247082219011045 0.00406717930063148 0.249687636403914 0.0327190014120969 miRNATAP -0.204666221256111 1.17123066701283e-05 NA NA NA hsa-miR-146b-5p CNTF 0.631041661167954 6.20366593452965e-08 -1.09998363599038 4.67486871319686e-18 MirTarget;miRanda -0.154795425926906 4.28509719951148e-05 NA NA NA hsa-miR-1976 CNTFR 0.289190368864725 0.00167092758216584 -4.18061105410292 1.90682468942591e-39 miRNATAP -0.577151185337326 3.55392037761081e-06 NA NA NA hsa-miR-200b-3p CNTFR 2.11744072703209 1.66710572104191e-43 -4.18061105410292 1.90682468942591e-39 TargetScan -0.554791324000155 1.82863912924816e-15 NA NA NA hsa-miR-200c-3p CNTFR 2.07038651806183 6.84613386286599e-51 -4.18061105410292 1.90682468942591e-39 miRNATAP -0.651234543642083 1.71163355931122e-17 NA NA NA hsa-miR-21-5p CNTFR 2.32007501846389 3.08394781855554e-137 -4.18061105410292 1.90682468942591e-39 miRNATAP -1.1291637732312 3.37574589247041e-29 NA NA NA hsa-miR-429 CNTFR 2.84108892259147 3.88520896426515e-64 -4.18061105410292 1.90682468942591e-39 PITA;miRanda;miRNATAP -0.572643184326223 2.19667161306476e-20 NA NA NA hsa-miR-484 CNTFR 0.349444060004737 0.00154491249625173 -4.18061105410292 1.90682468942591e-39 PITA;miRNATAP -0.449291284191843 1.44480684817562e-05 NA NA NA hsa-miR-361-5p CREBBP -0.0996867547900457 0.095428250126326 -0.207546077707359 0.000564449557347142 PITA;miRanda;miRNATAP -0.169327426710038 1.27069129226647e-06 NA NA NA hsa-miR-374a-3p CREBBP 0.34122393953022 2.28714105382856e-05 -0.207546077707359 0.000564449557347142 miRNATAP -0.118175129899399 3.92114134022804e-06 NA NA NA hsa-miR-590-3p CREBBP 1.27438512890514 1.03164723481469e-23 -0.207546077707359 0.000564449557347142 PITA;miRanda;mirMAP;miRNATAP -0.100564166407458 8.68617817381304e-10 NA NA NA hsa-miR-429 CSF2RA 2.84108892259147 3.88520896426515e-64 -0.427721480711688 0.000486382339897373 miRanda -0.100259679514765 1.5609930264171e-05 NA NA NA hsa-miR-125a-5p CSF2RB -0.635694700253268 3.6703235721638e-11 -0.429244381931033 0.00155997953965177 miRanda -0.342738630342494 5.64330349125e-13 NA NA NA hsa-miR-181c-5p CSF2RB 0.574847839298605 4.51287502066478e-07 -0.429244381931033 0.00155997953965177 MirTarget -0.117493887020018 0.00393145815724916 NA NA NA hsa-miR-181d-5p CSF2RB 0.782618466877349 1.2821116358212e-09 -0.429244381931033 0.00155997953965177 MirTarget -0.175286399953369 8.92491566553761e-07 NA NA NA hsa-miR-30b-3p CSF2RB -0.536462824497982 2.41814659272548e-05 -0.429244381931033 0.00155997953965177 MirTarget -0.171488311438998 2.87804505829104e-06 NA NA NA hsa-miR-141-3p CSF3 2.99777540204168 1.26370498493024e-78 -3.88687956855714 5.79181068171002e-45 TargetScan;miRNATAP -0.635639647527127 3.84247648434209e-31 NA NA NA hsa-miR-200a-3p CSF3 2.55218480823434 2.96135446816238e-51 -3.88687956855714 5.79181068171002e-45 miRNATAP -0.476735635349525 2.71347727473529e-18 NA NA NA hsa-miR-30b-3p CSF3R -0.536462824497982 2.41814659272548e-05 0.736535697973049 2.28188447740517e-06 MirTarget -0.135966153005423 0.00133826642524163 NA NA NA hsa-miR-185-3p CTF1 0.86591374114446 7.8790769678542e-10 -1.30167524419725 2.4875588830743e-16 MirTarget -0.300300613487652 1.50176702829548e-14 NA NA NA hsa-miR-185-5p CTF1 0.482334746589337 3.68475879959415e-09 -1.30167524419725 2.4875588830743e-16 MirTarget -0.359464228968005 9.2865632146664e-08 NA NA NA hsa-miR-590-3p CTF1 1.27438512890514 1.03164723481469e-23 -1.30167524419725 2.4875588830743e-16 miRanda -0.254475931296717 8.20155307851729e-09 NA NA NA hsa-miR-106b-5p EP300 1.22477789913175 2.31787213143326e-32 -0.378121576001413 5.1159454625656e-06 miRNATAP -0.191649543350323 2.95239597393248e-13 NA NA NA hsa-miR-181b-5p EP300 1.22749257795094 1.21998198830919e-27 -0.378121576001413 5.1159454625656e-06 miRNAWalker2_validate -0.187884049605316 7.93444158362854e-15 NA NA NA hsa-miR-20a-5p EP300 0.44979911120222 0.000602386964327228 -0.378121576001413 5.1159454625656e-06 miRNATAP -0.151748232339608 1.59846335234487e-12 NA NA NA hsa-miR-25-3p EP300 -0.00546790775985073 0.944061771389468 -0.378121576001413 5.1159454625656e-06 miRNAWalker2_validate -0.101950779775411 0.00585001386907759 NA NA NA hsa-miR-361-3p EP300 -0.0370446538644886 0.624902392829872 -0.378121576001413 5.1159454625656e-06 PITA -0.139187579360879 0.000249736724501524 NA NA NA hsa-miR-326 EPO -1.54449030848141 1.04703417845594e-17 1.40724311276675 1.13464399997793e-07 miRanda -0.181890696370513 0.000257743171960766 NA NA NA hsa-miR-142-3p GHR 1.53951237846104 2.06769936282034e-17 -3.36237154973502 5.01584120795748e-76 MirTarget;PITA;miRanda;miRNATAP -0.258278368150427 1.97065873638164e-12 NA NA NA hsa-miR-15a-5p GHR 0.812445324157528 4.50263417099822e-20 -3.36237154973502 5.01584120795748e-76 MirTarget;miRNATAP -0.605293472852955 7.30489418651164e-16 NA NA NA hsa-miR-15b-5p GHR 0.788659356634696 1.13678211092534e-11 -3.36237154973502 5.01584120795748e-76 MirTarget;miRNATAP -0.400222488614987 4.86555636936937e-12 NA NA NA hsa-miR-16-2-3p GHR 0.286355254959005 0.0256946046884474 -3.36237154973502 5.01584120795748e-76 mirMAP -0.302593175048704 1.65900338359926e-08 NA NA NA hsa-miR-16-5p GHR 0.46835991343556 1.91125356547776e-06 -3.36237154973502 5.01584120795748e-76 MirTarget;miRNATAP -0.35025844837926 4.66351956117755e-07 NA NA NA hsa-miR-29a-5p GHR 0.334183773952055 0.00445137265870197 -3.36237154973502 5.01584120795748e-76 mirMAP;miRNATAP -0.336628492524444 7.8070583731355e-09 NA NA NA hsa-miR-424-5p GHR 0.420789584199235 0.00480101660479489 -3.36237154973502 5.01584120795748e-76 MirTarget;miRNATAP -0.129234384065226 0.00501663875372727 NA NA NA hsa-miR-429 GHR 2.84108892259147 3.88520896426515e-64 -3.36237154973502 5.01584120795748e-76 miRanda;miRNATAP -0.565426163436487 1.88289719909835e-57 NA NA NA hsa-miR-455-5p GHR 0.284641224662773 0.0357572339594277 -3.36237154973502 5.01584120795748e-76 miRanda -0.358213904373597 9.36049755011874e-13 NA NA NA hsa-miR-590-3p GHR 1.27438512890514 1.03164723481469e-23 -3.36237154973502 5.01584120795748e-76 mirMAP -0.559291311133228 1.52163936994309e-25 NA NA NA hsa-miR-7-1-3p GHR 0.686579567507582 1.20731554448806e-07 -3.36237154973502 5.01584120795748e-76 MirTarget;mirMAP -0.252886866186807 1.44233263663563e-06 NA NA NA hsa-miR-100-5p GRB2 -1.89453309391092 5.00588682382388e-51 0.639828372471576 5.6864573011903e-23 miRNAWalker2_validate -0.156661486141178 3.5519143452408e-21 NA NA NA hsa-miR-378a-3p GRB2 -1.79882978380301 1.05005373951733e-38 0.639828372471576 5.6864573011903e-23 miRNAWalker2_validate;MirTarget;miRNATAP -0.128042134644829 1.17944311772052e-16 NA NA NA hsa-miR-378c GRB2 -1.79697571999492 1.07363220292403e-41 0.639828372471576 5.6864573011903e-23 MirTarget;miRNATAP -0.126006904107165 4.99041375742704e-15 NA NA NA hsa-miR-17-3p IFNAR1 0.721439431208839 7.95900548819742e-10 -0.376764183648069 3.13884253862067e-14 mirMAP -0.141624091960054 1.59714503842496e-23 NA NA NA hsa-miR-361-5p IFNAR1 -0.0996867547900457 0.095428250126326 -0.376764183648069 3.13884253862067e-14 miRanda -0.186548906123732 1.28504149793092e-10 NA NA NA hsa-miR-3913-5p IFNAR1 0.71890413546147 2.61153227160465e-13 -0.376764183648069 3.13884253862067e-14 mirMAP -0.143784211345676 3.40037571160059e-17 NA NA NA hsa-miR-342-3p IFNAR2 1.21944481975657 6.81914373001202e-19 -0.402774748171707 2.23085738240317e-07 miRanda -0.128014720473531 1.25634020519851e-11 NA NA NA hsa-miR-125a-5p IFNG -0.635694700253268 3.6703235721638e-11 0.469173337259002 0.065979531036782 miRanda -0.633234290202444 1.34334735769906e-12 NA NA NA hsa-miR-181b-5p IFNGR1 1.22749257795094 1.21998198830919e-27 -0.961189876051381 7.90304490354532e-39 miRNAWalker2_validate -0.116477918443014 2.80470202796018e-07 NA NA NA hsa-miR-429 IFNGR1 2.84108892259147 3.88520896426515e-64 -0.961189876051381 7.90304490354532e-39 miRNATAP -0.144785440240118 2.7420484507758e-24 NA NA NA hsa-miR-98-5p IFNGR1 0.656336869298973 9.03113188590466e-15 -0.961189876051381 7.90304490354532e-39 miRNAWalker2_validate -0.120928340595717 9.21804130022216e-05 NA NA NA hsa-let-7a-5p IL10 -0.210286642041636 0.0072546234707717 0.00418155538384124 0.977598291992666 TargetScan;miRNATAP -0.411293649396254 2.47232372843447e-10 NA NA NA hsa-let-7b-5p IL10 -0.54215483448257 7.21347617597858e-08 0.00418155538384124 0.977598291992666 miRNATAP -0.340320668706304 9.26035367991572e-12 NA NA NA hsa-miR-125a-5p IL10RA -0.635694700253268 3.6703235721638e-11 -0.151059584021612 0.230726426132862 miRanda -0.328531021179228 8.19955073885483e-14 NA NA NA hsa-miR-140-5p IL11 -0.755971041589807 9.68060922934542e-14 2.04832143954671 4.97278137496706e-38 miRanda -0.285248202520413 2.49619873242136e-07 NA NA NA hsa-miR-193a-3p IL11RA 0.310617999804917 0.00477640270974957 -1.62705709744929 4.66076538044481e-51 miRanda -0.206121178079653 7.96474136671345e-09 NA NA NA hsa-miR-330-5p IL11RA 0.626063225953928 3.42215028606779e-09 -1.62705709744929 4.66076538044481e-51 miRanda -0.358668915620866 3.38730160746101e-23 NA NA NA hsa-miR-125a-5p IL12RB2 -0.635694700253268 3.6703235721638e-11 -0.587964879769016 0.033469258581568 miRanda -0.344918250245832 0.000426325347172071 NA NA NA hsa-miR-199a-5p IL12RB2 -0.314703593105081 0.00909304983051124 -0.587964879769016 0.033469258581568 miRanda -0.349148444869695 8.51482873083486e-06 NA NA NA hsa-miR-338-3p IL12RB2 0.0799903526884966 0.575137668326679 -0.587964879769016 0.033469258581568 miRanda -0.275200482626183 3.39380002614706e-05 NA NA NA hsa-miR-342-3p IL12RB2 1.21944481975657 6.81914373001202e-19 -0.587964879769016 0.033469258581568 miRanda -0.390189235593381 6.05295593988818e-09 NA NA NA hsa-miR-128-3p IL13RA1 0.90296715955238 9.925204823863e-23 0.0785365367680315 0.282318167449858 MirTarget -0.166268247021324 2.65412487261913e-10 NA NA NA hsa-miR-155-5p IL13RA1 1.09766314984151 4.55650930885814e-15 0.0785365367680315 0.282318167449858 miRNAWalker2_validate;miRTarBase -0.100903915758177 7.01157648150312e-09 NA NA NA hsa-miR-16-2-3p IL13RA1 0.286355254959005 0.0256946046884474 0.0785365367680315 0.282318167449858 MirTarget -0.111502573364684 1.02220780967175e-08 NA NA NA hsa-miR-185-5p IL13RA1 0.482334746589337 3.68475879959415e-09 0.0785365367680315 0.282318167449858 MirTarget -0.160794768931472 1.14044551447585e-07 NA NA NA hsa-miR-28-5p IL13RA1 -0.14267073663385 0.0497619246260571 0.0785365367680315 0.282318167449858 miRanda -0.146588109721817 2.29274382682583e-05 NA NA NA hsa-miR-330-3p IL13RA1 0.432728362037032 0.00041335506960812 0.0785365367680315 0.282318167449858 MirTarget;PITA;miRNATAP -0.106078123617888 2.42159215937401e-07 NA NA NA hsa-miR-361-5p IL13RA1 -0.0996867547900457 0.095428250126326 0.0785365367680315 0.282318167449858 miRanda -0.321587957905821 1.62251431584436e-14 NA NA NA hsa-miR-148b-3p IL13RA2 1.0552576751879 1.6679285705231e-29 -0.363692428883498 0.0624618639947789 miRNAWalker2_validate -0.309977863565601 7.26484371511213e-06 NA NA NA hsa-miR-125a-5p IL15RA -0.635694700253268 3.6703235721638e-11 -0.70640205519099 2.34738349822176e-10 miRanda -0.265290163223662 1.81121058295005e-11 NA NA NA hsa-miR-342-3p IL15RA 1.21944481975657 6.81914373001202e-19 -0.70640205519099 2.34738349822176e-10 miRanda -0.134720189961362 8.75530278192058e-07 NA NA NA hsa-miR-140-3p IL19 -1.25844395244141 5.29222651039892e-33 2.30456974932921 8.19007459907496e-16 miRNATAP -0.48966767311445 7.39081345650223e-08 NA NA NA hsa-miR-532-3p IL19 -0.395473145042459 0.00686714288452761 2.30456974932921 8.19007459907496e-16 MirTarget;miRNATAP -0.192238502438703 0.00486587414894116 NA NA NA hsa-miR-590-3p IL20 1.27438512890514 1.03164723481469e-23 2.18775278512226 6.67274692435806e-09 miRanda -0.45259844755724 1.43447047853591e-05 NA NA NA hsa-miR-186-5p IL20RA -0.426987301460247 1.04129380549315e-05 -1.37963228673818 2.08954512354847e-08 mirMAP -0.372317431495323 2.13919583308481e-05 NA NA NA hsa-miR-338-3p IL20RA 0.0799903526884966 0.575137668326679 -1.37963228673818 2.08954512354847e-08 miRanda -0.225431565913738 0.000156225603294394 NA NA NA hsa-miR-590-3p IL20RA 1.27438512890514 1.03164723481469e-23 -1.37963228673818 2.08954512354847e-08 miRanda;mirMAP -0.426976683003151 2.67793998128377e-10 NA NA NA hsa-miR-335-5p IL21R -2.61355235628987 2.6462884165886e-51 2.59778925912353 5.84116459440323e-44 miRNAWalker2_validate -0.366295898138256 8.96485712037857e-25 NA NA NA hsa-miR-491-5p IL21R -1.04307210952796 1.14586501470398e-15 2.59778925912353 5.84116459440323e-44 MirTarget;miRanda -0.328742756638726 1.1266028265912e-10 NA NA NA hsa-miR-484 IL22RA1 0.349444060004737 0.00154491249625173 -1.49947488518615 4.3897867742091e-14 miRNATAP -0.200540074682764 0.00138416624174137 NA NA NA hsa-miR-3065-3p IL2RA 1.62787885002468 6.81477830005026e-19 0.552215139772291 0.00781659262634694 MirTarget -0.178827340978585 2.28054297181163e-06 NA NA NA hsa-miR-375 IL2RA 2.09893673049766 1.68351780396203e-16 0.552215139772291 0.00781659262634694 miRanda -0.226533685168416 3.8944695458836e-17 NA NA NA hsa-miR-125a-5p IL2RB -0.635694700253268 3.6703235721638e-11 0.409418481998368 0.0157972444641947 miRanda -0.29694183193025 7.00572007406091e-07 NA NA NA hsa-miR-30b-3p IL2RB -0.536462824497982 2.41814659272548e-05 0.409418481998368 0.0157972444641947 mirMAP -0.120917386166261 0.00852832449925365 NA NA NA hsa-miR-491-5p IL2RG -1.04307210952796 1.14586501470398e-15 0.527564404518184 0.0019177001745873 miRanda -0.177810126037921 6.02916563584062e-05 NA NA NA hsa-miR-331-3p IL4R 0.74441480542886 1.17071235477799e-07 -0.29952988564671 0.00152305772318984 miRNAWalker2_validate -0.164261893401686 3.92837965967983e-13 NA NA NA hsa-miR-339-5p IL4R -0.211548290465418 0.0685885445822389 -0.29952988564671 0.00152305772318984 miRanda -0.114416843350994 4.14803636170354e-05 NA NA NA hsa-miR-491-5p IL4R -1.04307210952796 1.14586501470398e-15 -0.29952988564671 0.00152305772318984 miRanda -0.104586865246844 2.11908180578236e-05 NA NA NA hsa-miR-107 IL6 0.678998026350662 2.56224148930538e-16 -3.07751927232311 9.9131162785608e-32 miRanda -0.335195787804263 0.00267549740903922 NA NA NA hsa-miR-429 IL6 2.84108892259147 3.88520896426515e-64 -3.07751927232311 9.9131162785608e-32 miRanda -0.424185146928772 6.81793191441461e-17 NA NA NA hsa-let-7e-5p IL6R 0.261471269338985 0.00191077095550257 -1.4959681212526 3.98690474593025e-23 miRNATAP -0.17507204538523 0.00585557898341552 NA NA NA hsa-miR-106b-5p IL6R 1.22477789913175 2.31787213143326e-32 -1.4959681212526 3.98690474593025e-23 mirMAP -0.307640134694259 3.99966327961051e-10 NA NA NA hsa-miR-130b-3p IL6R 1.38122163823846 1.00932179737836e-26 -1.4959681212526 3.98690474593025e-23 mirMAP -0.127525369485403 0.00150827294845077 NA NA NA hsa-miR-141-3p IL6R 2.99777540204168 1.26370498493024e-78 -1.4959681212526 3.98690474593025e-23 MirTarget -0.253098258336402 1.27382588367647e-17 NA NA NA hsa-miR-141-5p IL6R 2.38411349683216 4.56310582620282e-58 -1.4959681212526 3.98690474593025e-23 MirTarget -0.211774282012291 1.43748300605942e-10 NA NA NA hsa-miR-182-5p IL6R 2.36408084103818 2.60011457600281e-72 -1.4959681212526 3.98690474593025e-23 mirMAP -0.379208971544044 4.41744748962182e-26 NA NA NA hsa-miR-193a-3p IL6R 0.310617999804917 0.00477640270974957 -1.4959681212526 3.98690474593025e-23 mirMAP -0.186229101097756 0.00011695816491136 NA NA NA hsa-miR-193b-3p IL6R -0.0550374855074773 0.65382485898551 -1.4959681212526 3.98690474593025e-23 mirMAP -0.154861771649225 0.000363645984194793 NA NA NA hsa-miR-200a-3p IL6R 2.55218480823434 2.96135446816238e-51 -1.4959681212526 3.98690474593025e-23 MirTarget -0.235380598297946 6.33404340334906e-16 NA NA NA hsa-miR-20a-5p IL6R 0.44979911120222 0.000602386964327228 -1.4959681212526 3.98690474593025e-23 mirMAP -0.125418245247442 0.00197382511035134 NA NA NA hsa-miR-21-5p IL6R 2.32007501846389 3.08394781855554e-137 -1.4959681212526 3.98690474593025e-23 MirTarget;miRNATAP -0.329109136402319 6.05386734548003e-12 NA NA NA hsa-miR-301a-3p IL6R 1.32170168375632 2.12280368957514e-15 -1.4959681212526 3.98690474593025e-23 mirMAP -0.153584802129653 1.05970398736436e-06 NA NA NA hsa-miR-340-5p IL6R 1.0857159627596 4.94471062546756e-24 -1.4959681212526 3.98690474593025e-23 mirMAP -0.193028628130182 6.27919851615181e-05 NA NA NA hsa-miR-454-3p IL6R 1.28177672191095 6.84024979484587e-21 -1.4959681212526 3.98690474593025e-23 mirMAP -0.219027759212429 8.1279201972906e-09 NA NA NA hsa-miR-93-5p IL6R 1.01788600209314 1.24312921618126e-21 -1.4959681212526 3.98690474593025e-23 mirMAP -0.333750047512298 4.8028519401738e-12 NA NA NA hsa-miR-98-5p IL6R 0.656336869298973 9.03113188590466e-15 -1.4959681212526 3.98690474593025e-23 miRNAWalker2_validate -0.214105458008283 0.00057577278896208 NA NA NA hsa-miR-103a-3p IL6ST 0.610673390034345 1.63113920514646e-12 -1.52737235369582 4.44388978309665e-09 mirMAP -0.866671360669142 1.35699306218185e-17 NA NA NA hsa-miR-1301-3p IL6ST 1.80754972811286 2.96809840886499e-36 -1.52737235369582 4.44388978309665e-09 MirTarget -0.423496021869491 8.43141437896189e-13 NA NA NA hsa-miR-130b-3p IL6ST 1.38122163823846 1.00932179737836e-26 -1.52737235369582 4.44388978309665e-09 miRNATAP -0.612574347091891 3.40530466984167e-20 NA NA NA hsa-miR-132-3p IL6ST -0.0365213889238607 0.668598301088667 -1.52737235369582 4.44388978309665e-09 mirMAP -0.274534343528062 0.00992386031490921 NA NA NA hsa-miR-142-5p IL6ST 1.16509303143593 1.96641162209073e-13 -1.52737235369582 4.44388978309665e-09 MirTarget;PITA -0.209331380783649 0.000181030713748995 NA NA NA hsa-miR-146b-5p IL6ST 0.631041661167954 6.20366593452965e-08 -1.52737235369582 4.44388978309665e-09 miRanda -0.705259065998793 5.85314298105784e-21 NA NA NA hsa-miR-155-5p IL6ST 1.09766314984151 4.55650930885814e-15 -1.52737235369582 4.44388978309665e-09 mirMAP -0.462440195473775 1.29611565697689e-13 NA NA NA hsa-miR-16-1-3p IL6ST 1.30142784811196 2.53343713753744e-29 -1.52737235369582 4.44388978309665e-09 mirMAP -0.456120264904112 8.28649776349733e-09 NA NA NA hsa-miR-16-2-3p IL6ST 0.286355254959005 0.0256946046884474 -1.52737235369582 4.44388978309665e-09 mirMAP -0.326662102025027 3.519606689454e-06 NA NA NA hsa-miR-17-5p IL6ST 0.599531757298529 1.07318660415906e-05 -1.52737235369582 4.44388978309665e-09 TargetScan -0.721419097655266 8.44121396690599e-30 NA NA NA hsa-miR-181a-5p IL6ST 0.635863607630183 6.72486918157744e-11 -1.52737235369582 4.44388978309665e-09 mirMAP -0.838076802323856 9.54453094605953e-21 NA NA NA hsa-miR-181b-5p IL6ST 1.22749257795094 1.21998198830919e-27 -1.52737235369582 4.44388978309665e-09 mirMAP -0.844492026789875 1.66079885119429e-29 NA NA NA hsa-miR-181c-5p IL6ST 0.574847839298605 4.51287502066478e-07 -1.52737235369582 4.44388978309665e-09 mirMAP -0.365603681714535 3.16442133525746e-06 NA NA NA hsa-miR-186-5p IL6ST -0.426987301460247 1.04129380549315e-05 -1.52737235369582 4.44388978309665e-09 MirTarget;mirMAP -0.323060489048667 0.000506018873015772 NA NA NA hsa-miR-19a-3p IL6ST 0.817507952171848 3.76285090469625e-08 -1.52737235369582 4.44388978309665e-09 mirMAP;miRNATAP -0.659874083268663 6.63656958935598e-30 NA NA NA hsa-miR-19b-3p IL6ST 0.139124391010031 0.255658553872934 -1.52737235369582 4.44388978309665e-09 mirMAP;miRNATAP -0.616431485969597 1.70006148566761e-17 NA NA NA hsa-miR-200b-3p IL6ST 2.11744072703209 1.66710572104191e-43 -1.52737235369582 4.44388978309665e-09 TargetScan;mirMAP -0.261627924408914 2.44482742970634e-06 NA NA NA hsa-miR-200c-3p IL6ST 2.07038651806183 6.84613386286599e-51 -1.52737235369582 4.44388978309665e-09 mirMAP -0.317849621642354 1.84584384570656e-07 NA NA NA hsa-miR-20a-3p IL6ST -0.218902047543766 0.179868363625547 -1.52737235369582 4.44388978309665e-09 mirMAP -0.160129750293931 0.00384331662104776 NA NA NA hsa-miR-21-5p IL6ST 2.32007501846389 3.08394781855554e-137 -1.52737235369582 4.44388978309665e-09 mirMAP -0.56765013906967 2.31975560408847e-12 NA NA NA hsa-miR-212-3p IL6ST 0.24081906669865 0.0571447155653209 -1.52737235369582 4.44388978309665e-09 mirMAP -0.338410224951788 2.68530589975166e-06 NA NA NA hsa-miR-223-3p IL6ST -0.966406159689943 7.90612601654887e-12 -1.52737235369582 4.44388978309665e-09 MirTarget -0.223794440219529 0.00037556461069345 NA NA NA hsa-miR-24-2-5p IL6ST -0.222445793556803 0.059573849265115 -1.52737235369582 4.44388978309665e-09 MirTarget -0.266894142875601 0.00047500377419725 NA NA NA hsa-miR-301a-3p IL6ST 1.32170168375632 2.12280368957514e-15 -1.52737235369582 4.44388978309665e-09 mirMAP;miRNATAP -0.368891846336071 3.02249630289664e-12 NA NA NA hsa-miR-3065-3p IL6ST 1.62787885002468 6.81477830005026e-19 -1.52737235369582 4.44388978309665e-09 miRNATAP -0.203810451020773 2.0824444792229e-05 NA NA NA hsa-miR-30e-5p IL6ST 0.293491764699475 0.000372291967271834 -1.52737235369582 4.44388978309665e-09 mirMAP -0.35665830619219 0.00114794478061942 NA NA NA hsa-miR-330-3p IL6ST 0.432728362037032 0.00041335506960812 -1.52737235369582 4.44388978309665e-09 PITA;mirMAP -0.192842826982515 0.00964729119595311 NA NA NA hsa-miR-33a-5p IL6ST 1.35185127289399 9.80509199125785e-12 -1.52737235369582 4.44388978309665e-09 mirMAP -0.213518782697139 2.68404882262587e-06 NA NA NA hsa-miR-361-5p IL6ST -0.0996867547900457 0.095428250126326 -1.52737235369582 4.44388978309665e-09 mirMAP -1.18283822411403 4.59181327991361e-15 NA NA NA hsa-miR-362-5p IL6ST -0.248676340901797 0.0726089851456282 -1.52737235369582 4.44388978309665e-09 mirMAP -0.647894072066638 1.34129917044021e-24 NA NA NA hsa-miR-369-3p IL6ST 0.0880848299432269 0.48519534195924 -1.52737235369582 4.44388978309665e-09 mirMAP -0.221034926981582 0.00211584259122116 NA NA NA hsa-miR-374a-3p IL6ST 0.34122393953022 2.28714105382856e-05 -1.52737235369582 4.44388978309665e-09 mirMAP -0.677163305947457 1.15933226716639e-09 NA NA NA hsa-miR-378a-3p IL6ST -1.79882978380301 1.05005373951733e-38 -1.52737235369582 4.44388978309665e-09 miRNATAP -0.300723887159714 1.17366010660533e-06 NA NA NA hsa-miR-378c IL6ST -1.79697571999492 1.07363220292403e-41 -1.52737235369582 4.44388978309665e-09 miRNATAP -0.172816818936417 0.00749765271572723 NA NA NA hsa-miR-429 IL6ST 2.84108892259147 3.88520896426515e-64 -1.52737235369582 4.44388978309665e-09 PITA;miRanda;mirMAP;miRNATAP -0.326861790658869 3.22589396227134e-11 NA NA NA hsa-miR-452-5p IL6ST -2.48486455572568 1.24430987974325e-33 -1.52737235369582 4.44388978309665e-09 mirMAP -0.219664066998091 1.43869954863149e-07 NA NA NA hsa-miR-454-3p IL6ST 1.28177672191095 6.84024979484587e-21 -1.52737235369582 4.44388978309665e-09 mirMAP;miRNATAP -0.315441765633571 9.93148941981391e-07 NA NA NA hsa-miR-455-5p IL6ST 0.284641224662773 0.0357572339594277 -1.52737235369582 4.44388978309665e-09 miRanda -0.682839098700507 3.81950149520142e-26 NA NA NA hsa-miR-505-3p IL6ST -0.530462599544864 7.71645736541597e-05 -1.52737235369582 4.44388978309665e-09 MirTarget -0.425004001090291 1.47383606148954e-10 NA NA NA hsa-miR-532-5p IL6ST 0.0386976222860582 0.682018574136515 -1.52737235369582 4.44388978309665e-09 PITA -0.750431392606391 1.89981955347001e-15 NA NA NA hsa-miR-576-5p IL6ST 0.0649387707567879 0.588791966096287 -1.52737235369582 4.44388978309665e-09 mirMAP -0.300882597629006 6.08965726217443e-05 NA NA NA hsa-miR-582-5p IL6ST 0.201134299470983 0.149482495292227 -1.52737235369582 4.44388978309665e-09 mirMAP -0.267095895115439 4.18723532055781e-05 NA NA NA hsa-miR-584-5p IL6ST -1.75458362433615 2.80754771470968e-33 -1.52737235369582 4.44388978309665e-09 mirMAP -0.251814123613635 2.03170765446513e-05 NA NA NA hsa-miR-589-3p IL6ST 0.0263457630961427 0.866577983997705 -1.52737235369582 4.44388978309665e-09 mirMAP -0.154939318682275 0.00849290694938659 NA NA NA hsa-miR-590-3p IL6ST 1.27438512890514 1.03164723481469e-23 -1.52737235369582 4.44388978309665e-09 miRNAWalker2_validate;miRanda;mirMAP;miRNATAP -0.537431038928121 4.40579935427369e-14 NA NA NA hsa-miR-590-5p IL6ST 0.746515607868274 8.51300479640125e-09 -1.52737235369582 4.44388978309665e-09 mirMAP -0.586487828980855 4.48911570245129e-18 NA NA NA hsa-miR-766-3p IL6ST 0.496790679032227 8.22686414022553e-05 -1.52737235369582 4.44388978309665e-09 MirTarget -0.215179650545802 0.00252690012679202 NA NA NA hsa-miR-93-3p IL6ST 0.627759242044891 3.62527588304617e-06 -1.52737235369582 4.44388978309665e-09 MirTarget -0.307684505331865 3.05049308983912e-06 NA NA NA hsa-miR-192-5p IL7 1.33366224451777 9.5116159697107e-29 -1.15623141298675 2.89787466175942e-14 miRNAWalker2_validate -0.140015624448661 0.00104644268433873 NA NA NA hsa-miR-429 IL7 2.84108892259147 3.88520896426515e-64 -1.15623141298675 2.89787466175942e-14 miRanda -0.191776055201327 3.56427683831472e-11 NA NA NA hsa-miR-181a-5p IL7R 0.635863607630183 6.72486918157744e-11 -0.94953189474671 0.000239240351308242 mirMAP -0.278666463769429 0.00209346116355377 NA NA NA hsa-miR-181b-5p IL7R 1.22749257795094 1.21998198830919e-27 -0.94953189474671 0.000239240351308242 mirMAP -0.268069156007438 0.000450229999141897 NA NA NA hsa-miR-181c-5p IL7R 0.574847839298605 4.51287502066478e-07 -0.94953189474671 0.000239240351308242 mirMAP -0.201331441874885 0.00962448518990064 NA NA NA hsa-miR-199a-5p IRF9 -0.314703593105081 0.00909304983051124 1.02219179848776 1.55515376741471e-24 miRanda -0.173028993264251 2.55061883232948e-09 NA NA NA hsa-miR-199b-5p IRF9 -1.37022396448377 3.25758057539223e-26 1.02219179848776 1.55515376741471e-24 miRanda -0.184894666530623 1.49392695074048e-12 NA NA NA hsa-miR-106b-5p JAK1 1.22477789913175 2.31787213143326e-32 -0.707887486984647 1.74800811102416e-25 miRNAWalker2_validate;MirTarget -0.237214698790733 4.89804513217782e-28 NA NA NA hsa-miR-128-3p JAK1 0.90296715955238 9.925204823863e-23 -0.707887486984647 1.74800811102416e-25 miRNAWalker2_validate -0.207402426169231 1.10214403924094e-16 NA NA NA hsa-miR-15b-5p JAK1 0.788659356634696 1.13678211092534e-11 -0.707887486984647 1.74800811102416e-25 miRNAWalker2_validate -0.136277035192922 1.43927343310931e-11 NA NA NA hsa-miR-17-5p JAK1 0.599531757298529 1.07318660415906e-05 -0.707887486984647 1.74800811102416e-25 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.130465097982384 4.14656265736306e-14 NA NA NA hsa-miR-20a-5p JAK1 0.44979911120222 0.000602386964327228 -0.707887486984647 1.74800811102416e-25 MirTarget -0.197828753019475 3.07441583635672e-29 NA NA NA hsa-miR-30d-5p JAK1 -0.247082219011045 0.00406717930063148 -0.707887486984647 1.74800811102416e-25 MirTarget -0.107054413197506 0.000126918699137881 NA NA NA hsa-miR-340-5p JAK1 1.0857159627596 4.94471062546756e-24 -0.707887486984647 1.74800811102416e-25 MirTarget -0.203953564859323 7.04769381259905e-22 NA NA NA hsa-miR-455-5p JAK1 0.284641224662773 0.0357572339594277 -0.707887486984647 1.74800811102416e-25 miRanda -0.111576100008034 1.90906613010571e-10 NA NA NA hsa-miR-93-5p JAK1 1.01788600209314 1.24312921618126e-21 -0.707887486984647 1.74800811102416e-25 MirTarget;miRNATAP -0.254149430182059 2.35024916289304e-33 NA NA NA hsa-miR-181b-5p JAK2 1.22749257795094 1.21998198830919e-27 -0.676025901327081 1.66897086621935e-13 mirMAP -0.244633185822312 7.80530437489859e-20 NA NA NA hsa-miR-30b-3p JAK3 -0.536462824497982 2.41814659272548e-05 0.393594308074697 0.00524109684441821 MirTarget -0.214091337771 1.67341044412352e-08 NA NA NA hsa-miR-130b-5p LEP 1.0573161199584 2.55177349228739e-12 -7.67518473730639 1.72637364788671e-75 mirMAP -0.852879047255708 3.14508761124069e-17 NA NA NA hsa-miR-27b-5p LEP 0.478244809913032 2.28657237923291e-06 -7.67518473730639 1.72637364788671e-75 mirMAP -0.400887953074873 0.00992829140035282 NA NA NA hsa-miR-29b-3p LEP 0.438847962603729 6.46722433236121e-05 -7.67518473730639 1.72637364788671e-75 miRNATAP -0.526540889642395 0.000232707645411421 NA NA NA hsa-miR-330-3p LEP 0.432728362037032 0.00041335506960812 -7.67518473730639 1.72637364788671e-75 mirMAP -0.531369216043431 4.28888310667331e-05 NA NA NA hsa-miR-330-5p LEP 0.626063225953928 3.42215028606779e-09 -7.67518473730639 1.72637364788671e-75 miRanda -1.06705544039043 2.55717831715332e-13 NA NA NA hsa-miR-342-3p LEP 1.21944481975657 6.81914373001202e-19 -7.67518473730639 1.72637364788671e-75 miRanda -0.709224674762855 1.79405802467657e-10 NA NA NA hsa-miR-375 LEP 2.09893673049766 1.68351780396203e-16 -7.67518473730639 1.72637364788671e-75 mirMAP -0.357295375224867 2.79170660849737e-09 NA NA NA hsa-miR-590-3p LEP 1.27438512890514 1.03164723481469e-23 -7.67518473730639 1.72637364788671e-75 mirMAP -1.13003796848405 5.71763293275875e-20 NA NA NA hsa-let-7a-3p LEPR 0.466622567891891 3.70886257943079e-07 -3.24143926522135 2.40158609979225e-92 mirMAP -0.389462530440192 3.91857073400639e-09 NA NA NA hsa-let-7f-1-3p LEPR 0.37532726250321 0.00156021688753682 -3.24143926522135 2.40158609979225e-92 mirMAP -0.185834143974993 0.000376699450762934 NA NA NA hsa-miR-107 LEPR 0.678998026350662 2.56224148930538e-16 -3.24143926522135 2.40158609979225e-92 miRanda -0.650199086919738 9.52631335835176e-20 NA NA NA hsa-miR-130b-5p LEPR 1.0573161199584 2.55177349228739e-12 -3.24143926522135 2.40158609979225e-92 mirMAP -0.351048137223331 3.39262447544351e-19 NA NA NA hsa-miR-16-1-3p LEPR 1.30142784811196 2.53343713753744e-29 -3.24143926522135 2.40158609979225e-92 mirMAP -0.590266309944175 1.85972234940592e-29 NA NA NA hsa-miR-16-2-3p LEPR 0.286355254959005 0.0256946046884474 -3.24143926522135 2.40158609979225e-92 mirMAP -0.310804070445729 6.61482983158349e-11 NA NA NA hsa-miR-29a-5p LEPR 0.334183773952055 0.00445137265870197 -3.24143926522135 2.40158609979225e-92 mirMAP -0.196615580442853 0.00016731890837535 NA NA NA hsa-miR-320b LEPR 0.412787504747938 0.00113457276903985 -3.24143926522135 2.40158609979225e-92 miRanda -0.252399046973792 1.69994535962238e-07 NA NA NA hsa-miR-330-5p LEPR 0.626063225953928 3.42215028606779e-09 -3.24143926522135 2.40158609979225e-92 miRanda -0.313008444073696 4.27687566027306e-08 NA NA NA hsa-miR-340-5p LEPR 1.0857159627596 4.94471062546756e-24 -3.24143926522135 2.40158609979225e-92 mirMAP -0.402159828206131 2.39109173819714e-13 NA NA NA hsa-miR-342-3p LEPR 1.21944481975657 6.81914373001202e-19 -3.24143926522135 2.40158609979225e-92 miRanda -0.314557046784269 2.8966503098295e-13 NA NA NA hsa-miR-429 LEPR 2.84108892259147 3.88520896426515e-64 -3.24143926522135 2.40158609979225e-92 miRanda;miRNATAP -0.483071748248401 2.53285744438158e-52 NA NA NA hsa-miR-576-5p LEPR 0.0649387707567879 0.588791966096287 -3.24143926522135 2.40158609979225e-92 PITA -0.190337758692316 0.000193732008964133 NA NA NA hsa-miR-590-3p LEPR 1.27438512890514 1.03164723481469e-23 -3.24143926522135 2.40158609979225e-92 miRanda;mirMAP -0.514759602681661 2.80648471789456e-27 NA NA NA hsa-miR-590-5p LEPR 0.746515607868274 8.51300479640125e-09 -3.24143926522135 2.40158609979225e-92 miRanda -0.424366188634251 2.28561711324811e-20 NA NA NA hsa-miR-660-5p LEPR 0.406910761707485 0.000156175371762464 -3.24143926522135 2.40158609979225e-92 MirTarget -0.321166684222941 1.33570345156659e-08 NA NA NA hsa-miR-7-1-3p LEPR 0.686579567507582 1.20731554448806e-07 -3.24143926522135 2.40158609979225e-92 mirMAP -0.303520920925426 6.5503236251855e-11 NA NA NA hsa-miR-106b-5p LIF 1.22477789913175 2.31787213143326e-32 -0.905887057866458 4.87585212725247e-08 miRNATAP -0.144917461557169 0.00676558758628581 NA NA NA hsa-miR-125a-5p LIF -0.635694700253268 3.6703235721638e-11 -0.905887057866458 4.87585212725247e-08 miRNAWalker2_validate;miRanda;mirMAP;miRNATAP -0.199622616811164 0.000750954343434112 25962054 MicroRNA 125a influences breast cancer stem cells by targeting leukemia inhibitory factor receptor which regulates the Hippo signaling pathway breast cancer hsa-miR-141-3p LIF 2.99777540204168 1.26370498493024e-78 -0.905887057866458 4.87585212725247e-08 mirMAP -0.209274341605771 8.13949251394338e-11 NA NA NA hsa-miR-149-5p LIF 0.218233101703391 0.261629158371175 -0.905887057866458 4.87585212725247e-08 mirMAP -0.186743543935468 1.64287267728219e-10 NA NA NA hsa-miR-193a-3p LIF 0.310617999804917 0.00477640270974957 -0.905887057866458 4.87585212725247e-08 miRanda -0.338627138408113 5.60185981789573e-11 NA NA NA hsa-miR-200a-3p LIF 2.55218480823434 2.96135446816238e-51 -0.905887057866458 4.87585212725247e-08 mirMAP -0.141099841954999 9.16221284800043e-06 NA NA NA hsa-miR-29b-3p LIF 0.438847962603729 6.46722433236121e-05 -0.905887057866458 4.87585212725247e-08 MirTarget;miRNATAP -0.235696617726283 5.8197614889905e-06 NA NA NA hsa-miR-324-3p LIF 0.404877731996915 0.000340036423920834 -0.905887057866458 4.87585212725247e-08 miRNATAP -0.239486256353337 2.1578022792449e-06 NA NA NA hsa-miR-330-5p LIF 0.626063225953928 3.42215028606779e-09 -0.905887057866458 4.87585212725247e-08 miRNAWalker2_validate -0.197226789363275 0.000243370259098189 NA NA NA hsa-miR-590-3p LIF 1.27438512890514 1.03164723481469e-23 -0.905887057866458 4.87585212725247e-08 miRanda -0.133430136635564 0.00371539670106172 NA NA NA hsa-miR-769-5p LIF 0.564871766265874 8.16695101656941e-10 -0.905887057866458 4.87585212725247e-08 miRNATAP -0.272417907129098 1.06945375462469e-05 NA NA NA hsa-let-7a-3p LIFR 0.466622567891891 3.70886257943079e-07 -3.04175429528162 6.69458064740976e-81 mirMAP -0.283728485412966 1.61029768502319e-05 NA NA NA hsa-let-7f-1-3p LIFR 0.37532726250321 0.00156021688753682 -3.04175429528162 6.69458064740976e-81 mirMAP -0.185689011222998 0.000330593601492277 NA NA NA hsa-miR-128-3p LIFR 0.90296715955238 9.925204823863e-23 -3.04175429528162 6.69458064740976e-81 miRNAWalker2_validate -0.60684473523473 4.92839808772541e-22 NA NA NA hsa-miR-142-3p LIFR 1.53951237846104 2.06769936282034e-17 -3.04175429528162 6.69458064740976e-81 miRNATAP -0.219783619684968 1.1630439233846e-11 NA NA NA hsa-miR-142-5p LIFR 1.16509303143593 1.96641162209073e-13 -3.04175429528162 6.69458064740976e-81 PITA;mirMAP -0.197422224938135 1.38534066349466e-07 NA NA NA hsa-miR-148a-5p LIFR 0.572692271754695 2.14306251522796e-06 -3.04175429528162 6.69458064740976e-81 mirMAP -0.131904916855192 0.00836643589165914 NA NA NA hsa-miR-182-5p LIFR 2.36408084103818 2.60011457600281e-72 -3.04175429528162 6.69458064740976e-81 mirMAP -0.387254780967205 5.1668024342183e-21 NA NA NA hsa-miR-19a-3p LIFR 0.817507952171848 3.76285090469625e-08 -3.04175429528162 6.69458064740976e-81 mirMAP -0.32588816755867 2.70435884379571e-16 NA NA NA hsa-miR-19b-3p LIFR 0.139124391010031 0.255658553872934 -3.04175429528162 6.69458064740976e-81 mirMAP -0.199567820514504 5.64262922313313e-05 NA NA NA hsa-miR-203a-3p LIFR 1.67084394806148 6.06522273352132e-14 -3.04175429528162 6.69458064740976e-81 MirTarget -0.229125376726489 2.66632353122123e-18 NA NA NA hsa-miR-21-5p LIFR 2.32007501846389 3.08394781855554e-137 -3.04175429528162 6.69458064740976e-81 miRNAWalker2_validate -0.845255051722729 1.67109223795086e-61 NA NA NA hsa-miR-27a-3p LIFR 0.388496361379095 1.42373532086331e-05 -3.04175429528162 6.69458064740976e-81 miRNAWalker2_validate;MirTarget;miRNATAP -0.529836376349686 2.07050391576087e-15 NA NA NA hsa-miR-27b-3p LIFR -0.0796803270437447 0.410503155574393 -3.04175429528162 6.69458064740976e-81 MirTarget;miRNATAP -0.166407960882117 0.00825989845721025 NA NA NA hsa-miR-30d-3p LIFR 0.264544633563642 0.00755023189129747 -3.04175429528162 6.69458064740976e-81 mirMAP -0.264365676882931 1.60820149810744e-05 NA NA NA hsa-miR-320b LIFR 0.412787504747938 0.00113457276903985 -3.04175429528162 6.69458064740976e-81 miRanda -0.199605935938188 3.09895121067652e-05 NA NA NA hsa-miR-374a-3p LIFR 0.34122393953022 2.28714105382856e-05 -3.04175429528162 6.69458064740976e-81 miRNATAP -0.24606876590496 0.00111438026577164 NA NA NA hsa-miR-429 LIFR 2.84108892259147 3.88520896426515e-64 -3.04175429528162 6.69458064740976e-81 miRanda -0.419771299608504 1.90312382606979e-39 NA NA NA hsa-miR-500a-5p LIFR 0.209805801129289 0.119177819862398 -3.04175429528162 6.69458064740976e-81 mirMAP -0.225251260667712 7.42588852191933e-07 NA NA NA hsa-miR-590-3p LIFR 1.27438512890514 1.03164723481469e-23 -3.04175429528162 6.69458064740976e-81 miRanda;mirMAP -0.437160363263133 3.72866531148678e-20 NA NA NA hsa-miR-590-5p LIFR 0.746515607868274 8.51300479640125e-09 -3.04175429528162 6.69458064740976e-81 PITA;miRNATAP -0.357066784085135 5.92306641041245e-15 NA NA NA hsa-miR-629-3p LIFR 1.25035919247365 3.91361135469024e-14 -3.04175429528162 6.69458064740976e-81 miRNATAP -0.216426430715618 5.16108108882902e-09 NA NA NA hsa-miR-708-3p LIFR 0.478640655706813 2.13865852505288e-05 -3.04175429528162 6.69458064740976e-81 mirMAP -0.31267735241182 4.58915580607035e-09 NA NA NA hsa-miR-9-5p LIFR 0.734772328078424 0.00261982843636383 -3.04175429528162 6.69458064740976e-81 miRNATAP -0.13359218276504 5.61297277046889e-08 NA NA NA hsa-miR-96-5p LIFR 3.24596558166606 1.92296159041707e-98 -3.04175429528162 6.69458064740976e-81 mirMAP -0.442898805496316 2.33509823126837e-40 NA NA NA hsa-miR-98-5p LIFR 0.656336869298973 9.03113188590466e-15 -3.04175429528162 6.69458064740976e-81 miRNAWalker2_validate -0.514207012479569 2.00443977934157e-13 NA NA NA hsa-let-7e-5p MPL 0.261471269338985 0.00191077095550257 -1.55729613911731 1.15011006095171e-60 miRNAWalker2_validate -0.108150095010754 0.009759901565627 NA NA NA hsa-miR-128-3p MPL 0.90296715955238 9.925204823863e-23 -1.55729613911731 1.15011006095171e-60 MirTarget -0.187743832974474 4.12181479057262e-07 NA NA NA hsa-miR-342-5p MPL 1.49554286219821 1.56221300255782e-22 -1.55729613911731 1.15011006095171e-60 MirTarget -0.126334220760163 1.14279133874798e-08 NA NA NA hsa-miR-542-3p MPL 0.568822103820889 8.5699075257651e-07 -1.55729613911731 1.15011006095171e-60 miRanda -0.155234575321259 2.41010750486382e-07 NA NA NA hsa-miR-625-5p MPL 0.728939236913178 5.97591217674307e-08 -1.55729613911731 1.15011006095171e-60 MirTarget -0.133821823122263 4.90744218935631e-07 NA NA NA hsa-miR-708-3p MPL 0.478640655706813 2.13865852505288e-05 -1.55729613911731 1.15011006095171e-60 miRNAWalker2_validate;miRTarBase -0.110605765248542 0.000365524846664068 NA NA NA hsa-miR-98-5p MPL 0.656336869298973 9.03113188590466e-15 -1.55729613911731 1.15011006095171e-60 miRNAWalker2_validate -0.129087591561735 0.00163257094700731 NA NA NA hsa-miR-21-5p MYC 2.32007501846389 3.08394781855554e-137 -1.13124656428776 3.22608205108151e-16 miRNAWalker2_validate -0.270190862069706 5.76701615920235e-10 22072622 In contrast the levels of β-catenin TCF/LEF activity and the expression of c-Myc Cyclin-D which are increased in CSCs are also augmented in miR-21 overexpressing colon cancer cells accompanied by an increased sphere forming ability in vitro and tumor formation in SCID mice colon cancer hsa-miR-34a-5p MYC 0.129201805242403 0.133261654068224 -1.13124656428776 3.22608205108151e-16 miRNAWalker2_validate;miRTarBase -0.216308870548993 0.000129276161670072 25572695;25686834;21460242;22159222;23640973;22830357;22235332 The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;miR 34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c Myc pathway;Myc mediated repression of microRNA 34a promotes high grade transformation of B cell lymphoma by dysregulation of FoxP1;MicroRNA 34a suppresses malignant transformation by targeting c Myc transcriptional complexes in human renal cell carcinoma; We investigated the functional effects of microRNA-34a miR-34a on c-Myc transcriptional complexes in renal cell carcinoma; miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region which was revealed by luciferase reporter assays; Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription indicating a novel role of miR-34a in the regulation of transcription by c-Myc;Among them miR-34a was also associated with poor prognosis in 2 independent series of leukemic and nodal MCL and in cooperation with high expression of the MYC oncogene;We report that miR-34a did not inhibit cell proliferation notwithstanding a marked down-regulation of c-MYC;MicroRNA 34a modulates c Myc transcriptional complexes to suppress malignancy in human prostate cancer cells; We studied the functional effects of miR-34a on c-Myc transcriptional complexes in PC-3 prostate cancer cells; miR-34a downregulated expression of c-Myc oncogene by targeting its 3' UTR as shown by luciferase reporter assays; This is the first report to document that miR-34a suppresses assembly and function of the c-Myc-Skp2-Miz1 complex that activates RhoA and the c-Myc-pTEFB complex that elongates transcription of various genes suggesting a novel role of miR-34a in the regulation of transcription by c-Myc complex ;;;malignant trasformation;worse prognosis;; bladder cancer;liver cancer;B cell lymphoma;kidney renal cell cancer;lymphoma;lymphoma;prostate cancer hsa-miR-429 MYC 2.84108892259147 3.88520896426515e-64 -1.13124656428776 3.22608205108151e-16 miRNAWalker2_validate -0.108453248703558 4.76591679996824e-05 21684154;24633485 miR 429 modulates the expression of c myc in human gastric carcinoma cells; SGC-7901 gastric cancer cells were transfected with miR-429 mimics and endogenous c-myc expression was detected by western blots; We performed functional assays using the 3'UTR of the c-myc gene as a miR-429 target in a luciferase reporter assay system; miR-429 significantly downregulated endogenous c-myc expression in SGC-7901 cells; Action of miR/429 on c-myc 3'UTR was confirmed; c-myc is an important miR-429 target gene;It is known that miR-429 is down-regulated and functions as a tumor suppressor by targeting c-myc and PLGG1 in gastric and breast cancer ; gastric cancer;sarcoma hsa-miR-193a-3p OSMR 0.310617999804917 0.00477640270974957 -0.668362253183246 2.80577564076125e-06 MirTarget -0.129820817377299 0.00371242521618259 NA NA NA hsa-miR-200b-3p OSMR 2.11744072703209 1.66710572104191e-43 -0.668362253183246 2.80577564076125e-06 TargetScan -0.20408879563362 1.18112518586047e-11 NA NA NA hsa-miR-429 OSMR 2.84108892259147 3.88520896426515e-64 -0.668362253183246 2.80577564076125e-06 miRanda;miRNATAP -0.181544786242502 1.42143787332253e-11 NA NA NA hsa-miR-590-3p OSMR 1.27438512890514 1.03164723481469e-23 -0.668362253183246 2.80577564076125e-06 miRanda;mirMAP;miRNATAP -0.126738008266365 0.0012960013841292 NA NA NA hsa-miR-98-5p OSMR 0.656336869298973 9.03113188590466e-15 -0.668362253183246 2.80577564076125e-06 miRNAWalker2_validate -0.259591236387239 5.89309442597424e-06 NA NA NA hsa-miR-15a-5p PIAS2 0.812445324157528 4.50263417099822e-20 -0.0806880298063972 0.252327763186412 MirTarget -0.120292106307871 6.37618401122787e-06 NA NA NA hsa-miR-181a-5p PIAS2 0.635863607630183 6.72486918157744e-11 -0.0806880298063972 0.252327763186412 mirMAP -0.134039994104632 4.01002181065887e-08 NA NA NA hsa-miR-584-5p PIAS4 -1.75458362433615 2.80754771470968e-33 0.70855895965418 3.59978965399506e-27 mirMAP -0.105565440351353 2.61599017998967e-12 NA NA NA hsa-miR-146b-5p PIK3CA 0.631041661167954 6.20366593452965e-08 -0.881957552231161 1.15529457057533e-22 mirMAP -0.10172531442561 0.000163300940659646 NA NA NA hsa-miR-148a-5p PIK3CA 0.572692271754695 2.14306251522796e-06 -0.881957552231161 1.15529457057533e-22 mirMAP -0.111623090383025 1.82115916734019e-05 NA NA NA hsa-miR-200b-3p PIK3CA 2.11744072703209 1.66710572104191e-43 -0.881957552231161 1.15529457057533e-22 TargetScan -0.164394431071602 1.25931440199374e-17 NA NA NA hsa-miR-361-5p PIK3CA -0.0996867547900457 0.095428250126326 -0.881957552231161 1.15529457057533e-22 mirMAP -0.28523073173792 1.02307804662151e-07 NA NA NA hsa-miR-96-5p PIK3CA 3.24596558166606 1.92296159041707e-98 -0.881957552231161 1.15529457057533e-22 TargetScan -0.158039482109614 1.06514304964241e-18 NA NA NA hsa-miR-30b-3p PIK3CD -0.536462824497982 2.41814659272548e-05 -0.316904328019809 0.0048026997053421 MirTarget -0.12656414985523 3.07110294580941e-05 NA NA NA hsa-miR-484 PIK3CD 0.349444060004737 0.00154491249625173 -0.316904328019809 0.0048026997053421 MirTarget;miRNATAP -0.141552727299567 4.96089022907138e-05 NA NA NA hsa-miR-103a-3p PIK3R1 0.610673390034345 1.63113920514646e-12 -1.70627489565512 1.28475917565256e-44 MirTarget;miRNATAP -0.516011898515825 9.39970675304441e-26 NA NA NA hsa-miR-106b-5p PIK3R1 1.22477789913175 2.31787213143326e-32 -1.70627489565512 1.28475917565256e-44 MirTarget;miRNATAP -0.458684807618424 6.41212047089543e-31 NA NA NA hsa-miR-107 PIK3R1 0.678998026350662 2.56224148930538e-16 -1.70627489565512 1.28475917565256e-44 MirTarget;PITA;miRanda;miRNATAP -0.564782368968385 1.29413413077175e-28 NA NA NA hsa-miR-128-3p PIK3R1 0.90296715955238 9.925204823863e-23 -1.70627489565512 1.28475917565256e-44 MirTarget -0.464882086210543 2.18929508374026e-24 25962360 miR 128 3p suppresses hepatocellular carcinoma proliferation by regulating PIK3R1 and is correlated with the prognosis of HCC patients; Mechanistically miR-128-3p was confirmed to regulate PIK3R1 p85α expression thereby suppressing phosphatidylinositol 3-kinase PI3K/AKT pathway activation using qRT-PCR and western blot analysis; Hence we conclude that miR-128-3p which is frequently downregulated in HCC inhibits HCC progression by regulating PIK3R1 and PI3K/AKT activation and is a prognostic marker for HCC patients worse prognosis;progression liver cancer hsa-miR-1301-3p PIK3R1 1.80754972811286 2.96809840886499e-36 -1.70627489565512 1.28475917565256e-44 MirTarget -0.312737279865189 3.51588268231222e-28 NA NA NA hsa-miR-15a-5p PIK3R1 0.812445324157528 4.50263417099822e-20 -1.70627489565512 1.28475917565256e-44 MirTarget -0.467053807879393 1.27196995879228e-22 NA NA NA hsa-miR-15b-5p PIK3R1 0.788659356634696 1.13678211092534e-11 -1.70627489565512 1.28475917565256e-44 MirTarget -0.304923263873542 1.52536411684308e-16 NA NA NA hsa-miR-16-2-3p PIK3R1 0.286355254959005 0.0256946046884474 -1.70627489565512 1.28475917565256e-44 MirTarget -0.187390623272605 5.18756959426033e-08 NA NA NA hsa-miR-16-5p PIK3R1 0.46835991343556 1.91125356547776e-06 -1.70627489565512 1.28475917565256e-44 MirTarget -0.185144677288316 3.4393027748885e-05 NA NA NA hsa-miR-17-5p PIK3R1 0.599531757298529 1.07318660415906e-05 -1.70627489565512 1.28475917565256e-44 MirTarget;TargetScan;miRNATAP -0.305623214527227 2.73465966965389e-22 NA NA NA hsa-miR-182-5p PIK3R1 2.36408084103818 2.60011457600281e-72 -1.70627489565512 1.28475917565256e-44 miRNATAP -0.209986504782115 4.31661758321545e-12 NA NA NA hsa-miR-185-5p PIK3R1 0.482334746589337 3.68475879959415e-09 -1.70627489565512 1.28475917565256e-44 miRNATAP -0.576307293918371 1.92791131730155e-28 NA NA NA hsa-miR-200b-3p PIK3R1 2.11744072703209 1.66710572104191e-43 -1.70627489565512 1.28475917565256e-44 mirMAP -0.193888157381114 6.36921236487692e-13 NA NA NA hsa-miR-200c-3p PIK3R1 2.07038651806183 6.84613386286599e-51 -1.70627489565512 1.28475917565256e-44 mirMAP -0.257145031020416 2.3912254219973e-18 NA NA NA hsa-miR-20a-5p PIK3R1 0.44979911120222 0.000602386964327228 -1.70627489565512 1.28475917565256e-44 MirTarget;miRNATAP -0.329404805146422 7.47770247059783e-24 NA NA NA hsa-miR-21-5p PIK3R1 2.32007501846389 3.08394781855554e-137 -1.70627489565512 1.28475917565256e-44 miRNAWalker2_validate;MirTarget;miRNATAP -0.442813578327247 2.68375696066295e-30 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-29b-3p PIK3R1 0.438847962603729 6.46722433236121e-05 -1.70627489565512 1.28475917565256e-44 MirTarget;miRNATAP -0.212535407562809 1.00431864575306e-07 NA NA NA hsa-miR-320b PIK3R1 0.412787504747938 0.00113457276903985 -1.70627489565512 1.28475917565256e-44 miRNATAP -0.140552558146201 5.57745902628767e-05 NA NA NA hsa-miR-324-3p PIK3R1 0.404877731996915 0.000340036423920834 -1.70627489565512 1.28475917565256e-44 MirTarget;PITA;miRNATAP -0.224592588456891 6.81384539720142e-09 NA NA NA hsa-miR-330-3p PIK3R1 0.432728362037032 0.00041335506960812 -1.70627489565512 1.28475917565256e-44 MirTarget;PITA;miRNATAP -0.144041669892523 7.57903802651215e-05 NA NA NA hsa-miR-361-5p PIK3R1 -0.0996867547900457 0.095428250126326 -1.70627489565512 1.28475917565256e-44 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.278078422988115 0.000207710985727821 NA NA NA hsa-miR-429 PIK3R1 2.84108892259147 3.88520896426515e-64 -1.70627489565512 1.28475917565256e-44 mirMAP;miRNATAP -0.22503499935046 3.34180951947627e-21 NA NA NA hsa-miR-590-3p PIK3R1 1.27438512890514 1.03164723481469e-23 -1.70627489565512 1.28475917565256e-44 miRanda;mirMAP -0.239713681587516 7.2007499793076e-12 NA NA NA hsa-miR-590-5p PIK3R1 0.746515607868274 8.51300479640125e-09 -1.70627489565512 1.28475917565256e-44 MirTarget;PITA;miRanda;miRNATAP -0.209937562895491 3.68537681569131e-10 NA NA NA hsa-miR-629-3p PIK3R1 1.25035919247365 3.91361135469024e-14 -1.70627489565512 1.28475917565256e-44 MirTarget -0.122961236064884 5.54567297669118e-06 NA NA NA hsa-miR-93-5p PIK3R1 1.01788600209314 1.24312921618126e-21 -1.70627489565512 1.28475917565256e-44 MirTarget;miRNATAP -0.499295395694502 3.97678732290002e-38 NA NA NA hsa-miR-96-5p PIK3R1 3.24596558166606 1.92296159041707e-98 -1.70627489565512 1.28475917565256e-44 TargetScan;miRNATAP -0.245653154038236 3.77424010710224e-23 NA NA NA hsa-miR-126-3p PIK3R2 -1.17432628002954 1.02041618253013e-20 1.28293433832686 8.5972816204378e-73 miRNAWalker2_validate;miRTarBase -0.169496363080053 8.52458360518473e-17 21249429;26384552;27578985;26191164;25240815 Endothelial specific intron derived miR 126 is down regulated in human breast cancer and targets both VEGFA and PIK3R2; VEGFA and PIK3R2 were confirmed as the targets of miR-126 by luciferase reporter assay and Western blot;MicroRNA 126 suppresses proliferation of undifferentiated BRAFV600E and BRAFWT thyroid carcinoma through targeting PIK3R2 gene and repressing PI3K AKT proliferation survival signalling pathway; In addition miR-126 was found to act as proliferation suppressor targeting PIK3R2 gene and reducing p85β a regulatory subunit of PI3K kinase protein translation and lower AKT kinase activity;MiR 126 regulates proliferation and invasion in the bladder cancer BLS cell line by targeting the PIK3R2 mediated PI3K/Akt signaling pathway; A direct regulatory relationship between miR-126 and the PIK3R2 gene was demonstrated by luciferase reporter assays; Quantitative real-time polymerase chain reaction was used to measure miR-126 and PIK3R2 expressions; Luciferase assays showed that miR-126 significantly inhibited the PIK3R2 3' untranslated region 3'UTR luciferase reporter activity P<0.05; Overexpression of miR-126 negatively regulated the target gene PIK3R2 and further inhibited the PI3K/Akt signaling pathway thereby inhibiting proliferation migration and invasion and promoting apoptosis in BLS cells;Restoration of miR-126 in EC109 cells induced a reduction in PIK3R2 protein levels accompanied with a substantial reduction in phosphorylated AKT levels in EC109 cells suggesting impairment in PI3K/AKT signaling pathway; The luciferase reporter assay confirmed that PIK3R2 was a direct target of miR-126; Taken together our study suggests that miR-126 functions as a potential tumor suppressor in ESCC progression via regulating PI3K/AKT signaling pathway partly by targeting PIK3R2 and targeting of miR-126 may provide a novel strategy for the diagnosis and treatment of ESCC;MiR 126 3p suppresses tumor metastasis and angiogenesis of hepatocellular carcinoma by targeting LRP6 and PIK3R2; LRP6 and PIK3R2 were identified as targets of miR-126-3p; Silencing LRP6 and PIK3R2 had similar effects of miR-126-3p restoration on metastasis and angiogenesis individually in HCC cells; Furthermore the miR-126-3p level was inversely correlated with LRP6 and PIK3R2 in HCC tissues; In addition the rescue experiments indicated that the metastasis and angiogenesis functions of miR-126-3p were mediated by LRP6 and PIK3R2 ;poor survival;;progression;metastasis breast cancer;thyroid cancer;bladder cancer;esophageal cancer;liver cancer hsa-miR-28-5p PIK3R2 -0.14267073663385 0.0497619246260571 1.28293433832686 8.5972816204378e-73 miRanda -0.170225138245223 4.06181677270291e-06 NA NA NA hsa-miR-30b-5p PIK3R2 -0.46540603860146 2.4709940429591e-05 1.28293433832686 8.5972816204378e-73 miRNATAP -0.111541133552651 3.5447180691879e-06 NA NA NA hsa-miR-30c-5p PIK3R2 -0.393222674580066 8.06961465717306e-05 1.28293433832686 8.5972816204378e-73 miRNAWalker2_validate;miRNATAP -0.102854891876324 0.000118472431445014 NA NA NA hsa-miR-30d-5p PIK3R2 -0.247082219011045 0.00406717930063148 1.28293433832686 8.5972816204378e-73 miRNATAP -0.135541098242265 1.30568664423737e-05 NA NA NA hsa-miR-320a PIK3R2 -0.287921276129346 0.00141693637596294 1.28293433832686 8.5972816204378e-73 miRanda -0.151022063052727 3.16338469232646e-07 NA NA NA hsa-miR-491-5p PIK3R2 -1.04307210952796 1.14586501470398e-15 1.28293433832686 8.5972816204378e-73 miRanda -0.116485616092769 7.44579853361516e-09 NA NA NA hsa-miR-181a-5p PIK3R3 0.635863607630183 6.72486918157744e-11 0.559172960265555 3.98014986716526e-09 MirTarget;miRNATAP -0.146056981056209 1.20649375988888e-05 NA NA NA hsa-miR-19b-3p PIK3R3 0.139124391010031 0.255658553872934 0.559172960265555 3.98014986716526e-09 MirTarget;miRNATAP -0.109224067759979 4.71454242795867e-05 NA NA NA hsa-miR-217 PIK3R3 -0.616728851115349 8.64977119332241e-05 0.559172960265555 3.98014986716526e-09 PITA;miRanda -0.118432783728797 1.05730160913028e-08 NA NA NA hsa-miR-25-3p PIK3R3 -0.00546790775985073 0.944061771389468 0.559172960265555 3.98014986716526e-09 MirTarget -0.129911102729152 0.00226643466666436 NA NA NA hsa-miR-26a-5p PIK3R3 -0.481180084102235 1.82368246174758e-10 0.559172960265555 3.98014986716526e-09 miRNATAP -0.28216506702381 5.37056936747542e-11 NA NA NA hsa-miR-374a-5p PIK3R3 -0.239709888246804 0.00309819667153627 0.559172960265555 3.98014986716526e-09 mirMAP -0.121442827230575 0.0029020400924295 NA NA NA hsa-miR-374b-5p PIK3R3 -0.466781429946153 1.17238311619116e-08 0.559172960265555 3.98014986716526e-09 mirMAP -0.120196538768652 0.00271578207935794 NA NA NA hsa-miR-381-3p PIK3R3 -1.28028930293369 1.61402949866141e-23 0.559172960265555 3.98014986716526e-09 mirMAP -0.140767078074606 1.38941193259491e-08 NA NA NA hsa-miR-532-5p PIK3R3 0.0386976222860582 0.682018574136515 0.559172960265555 3.98014986716526e-09 mirMAP -0.140279487612118 5.85354025061255e-05 NA NA NA hsa-miR-92a-3p PIK3R3 -0.342420481092807 0.000732275969501111 0.559172960265555 3.98014986716526e-09 MirTarget;miRNATAP -0.227757876133252 1.19233380886192e-12 NA NA NA hsa-miR-125a-5p PIK3R5 -0.635694700253268 3.6703235721638e-11 0.311128035887536 0.0038375952038782 MirTarget;miRanda -0.280593880513026 8.91996620676494e-14 NA NA NA hsa-miR-182-5p PIK3R5 2.36408084103818 2.60011457600281e-72 0.311128035887536 0.0038375952038782 MirTarget -0.108305079676846 2.32094065834864e-05 NA NA NA hsa-miR-125a-5p PIM1 -0.635694700253268 3.6703235721638e-11 -0.543245722142204 4.23045104516197e-06 miRanda -0.157525198825984 0.000174805438011461 NA NA NA hsa-miR-183-5p PIM1 2.95681814393872 1.09965777344285e-92 -0.543245722142204 4.23045104516197e-06 miRNATAP -0.184619636188661 7.11720554709785e-14 NA NA NA hsa-miR-429 PIM1 2.84108892259147 3.88520896426515e-64 -0.543245722142204 4.23045104516197e-06 miRNATAP -0.103768468392563 3.58813451862755e-06 NA NA NA hsa-let-7d-5p PRLR 0.410958462607207 6.07808182756787e-06 1.27351378761725 5.27607801731441e-13 miRNATAP -0.272028887463407 5.47002790868371e-05 NA NA NA hsa-let-7g-5p PRLR 0.0200025784917734 0.791635298815256 1.27351378761725 5.27607801731441e-13 miRNATAP -0.233689111950248 0.00432433307799952 NA NA NA hsa-let-7i-5p PRLR -0.333419326258177 3.56960810786801e-08 1.27351378761725 5.27607801731441e-13 miRNATAP -0.891894607115349 5.32674075990505e-19 NA NA NA hsa-miR-130a-3p PRLR -1.15024914519431 6.51290317952496e-19 1.27351378761725 5.27607801731441e-13 mirMAP -0.279947802725982 1.17999346885074e-09 NA NA NA hsa-miR-130b-3p PRLR 1.38122163823846 1.00932179737836e-26 1.27351378761725 5.27607801731441e-13 mirMAP -0.209027118831004 6.01635346843064e-06 NA NA NA hsa-miR-144-5p PRLR -2.75914786146772 1.55794225315972e-50 1.27351378761725 5.27607801731441e-13 mirMAP -0.236248227916033 1.47242221155932e-14 NA NA NA hsa-miR-146a-5p PRLR 0.102405752365098 0.486975378688068 1.27351378761725 5.27607801731441e-13 mirMAP -0.216643212140334 1.7523725363952e-07 NA NA NA hsa-miR-146b-5p PRLR 0.631041661167954 6.20366593452965e-08 1.27351378761725 5.27607801731441e-13 mirMAP -0.273438844577925 1.499175856621e-07 NA NA NA hsa-miR-148a-5p PRLR 0.572692271754695 2.14306251522796e-06 1.27351378761725 5.27607801731441e-13 mirMAP -0.134817074373083 0.00772994956929194 NA NA NA hsa-miR-15b-3p PRLR 1.12898579025388 1.18050912917317e-14 1.27351378761725 5.27607801731441e-13 mirMAP -0.20538661765261 5.74164111841047e-07 NA NA NA hsa-miR-186-5p PRLR -0.426987301460247 1.04129380549315e-05 1.27351378761725 5.27607801731441e-13 mirMAP -0.401617770723117 1.53804520349439e-10 NA NA NA hsa-miR-19b-1-5p PRLR 0.647704962003062 3.07687667945597e-07 1.27351378761725 5.27607801731441e-13 mirMAP -0.240190669375244 5.7283975939384e-07 NA NA NA hsa-miR-20a-3p PRLR -0.218902047543766 0.179868363625547 1.27351378761725 5.27607801731441e-13 mirMAP -0.100128257767749 0.00798148046637221 NA NA NA hsa-miR-218-5p PRLR -1.02621788318234 2.9221925445771e-23 1.27351378761725 5.27607801731441e-13 miRNATAP -0.29105637420739 4.53057925873605e-07 NA NA NA hsa-miR-22-5p PRLR 0.238328801322329 0.0377496760295305 1.27351378761725 5.27607801731441e-13 mirMAP -0.384645099058839 3.6032680629659e-13 NA NA NA hsa-miR-26a-5p PRLR -0.481180084102235 1.82368246174758e-10 1.27351378761725 5.27607801731441e-13 mirMAP -0.305382365474339 0.000163973613234094 NA NA NA hsa-miR-29a-5p PRLR 0.334183773952055 0.00445137265870197 1.27351378761725 5.27607801731441e-13 mirMAP -0.148313104785018 0.00465886457453621 NA NA NA hsa-miR-320a PRLR -0.287921276129346 0.00141693637596294 1.27351378761725 5.27607801731441e-13 miRanda -0.273303361157844 6.0014526817036e-05 NA NA NA hsa-miR-320b PRLR 0.412787504747938 0.00113457276903985 1.27351378761725 5.27607801731441e-13 miRanda -0.159127665629827 0.00105334402901543 NA NA NA hsa-miR-340-5p PRLR 1.0857159627596 4.94471062546756e-24 1.27351378761725 5.27607801731441e-13 mirMAP -0.195410559131314 0.000446695295062688 NA NA NA hsa-miR-362-5p PRLR -0.248676340901797 0.0726089851456282 1.27351378761725 5.27607801731441e-13 mirMAP -0.415662010540809 7.35379555005751e-22 NA NA NA hsa-miR-374a-5p PRLR -0.239709888246804 0.00309819667153627 1.27351378761725 5.27607801731441e-13 mirMAP -0.390711651873163 2.52402677048321e-07 NA NA NA hsa-miR-374b-5p PRLR -0.466781429946153 1.17238311619116e-08 1.27351378761725 5.27607801731441e-13 mirMAP -0.442449213962816 2.60603911325557e-09 NA NA NA hsa-miR-376c-3p PRLR -1.23221625820254 6.08631316990405e-17 1.27351378761725 5.27607801731441e-13 mirMAP -0.151370891986081 0.000240338414209719 NA NA NA hsa-miR-381-3p PRLR -1.28028930293369 1.61402949866141e-23 1.27351378761725 5.27607801731441e-13 mirMAP -0.173226031819158 0.00020060668215085 NA NA NA hsa-miR-455-5p PRLR 0.284641224662773 0.0357572339594277 1.27351378761725 5.27607801731441e-13 miRanda -0.409759103505849 2.29594134369905e-20 NA NA NA hsa-miR-485-3p PRLR -0.866822427729628 4.5194665263492e-11 1.27351378761725 5.27607801731441e-13 mirMAP -0.136788990260707 0.00333895603024827 NA NA NA hsa-miR-495-3p PRLR -1.67685437612894 1.70634429769052e-34 1.27351378761725 5.27607801731441e-13 mirMAP -0.167341960291121 0.000100878102927204 NA NA NA hsa-miR-576-5p PRLR 0.0649387707567879 0.588791966096287 1.27351378761725 5.27607801731441e-13 mirMAP -0.236764414410884 3.49177562421495e-06 NA NA NA hsa-miR-582-5p PRLR 0.201134299470983 0.149482495292227 1.27351378761725 5.27607801731441e-13 PITA -0.210704711037092 2.00132240557531e-06 NA NA NA hsa-miR-589-3p PRLR 0.0263457630961427 0.866577983997705 1.27351378761725 5.27607801731441e-13 mirMAP -0.125275909775997 0.00176650789337072 NA NA NA hsa-miR-9-5p PRLR 0.734772328078424 0.00261982843636383 1.27351378761725 5.27607801731441e-13 miRNATAP -0.111874928161752 7.39049424501855e-06 NA NA NA hsa-miR-107 PTPN11 0.678998026350662 2.56224148930538e-16 -0.73371833861962 7.24333657010257e-22 miRanda -0.163662279556764 2.71436340594115e-07 NA NA NA hsa-miR-181a-5p PTPN11 0.635863607630183 6.72486918157744e-11 -0.73371833861962 7.24333657010257e-22 miRNAWalker2_validate;miRTarBase -0.203894811713478 3.88313891479703e-14 NA NA NA hsa-miR-200b-3p PTPN11 2.11744072703209 1.66710572104191e-43 -0.73371833861962 7.24333657010257e-22 TargetScan -0.131913631045747 6.43155343439281e-16 NA NA NA hsa-miR-200c-3p PTPN11 2.07038651806183 6.84613386286599e-51 -0.73371833861962 7.24333657010257e-22 miRNATAP -0.109200606157251 1.61966841065561e-09 NA NA NA hsa-miR-429 PTPN11 2.84108892259147 3.88520896426515e-64 -0.73371833861962 7.24333657010257e-22 miRNATAP -0.109747504497674 5.95008429105521e-14 NA NA NA hsa-miR-455-5p PTPN11 0.284641224662773 0.0357572339594277 -0.73371833861962 7.24333657010257e-22 miRanda -0.133690861612131 8.9309303633598e-12 NA NA NA hsa-miR-660-5p PTPN11 0.406910761707485 0.000156175371762464 -0.73371833861962 7.24333657010257e-22 mirMAP -0.21890971720391 2.98301188211193e-19 NA NA NA hsa-let-7a-5p SOCS1 -0.210286642041636 0.0072546234707717 0.463525464851224 0.00255751332764507 TargetScan -0.404776321447853 1.82552304423875e-09 NA NA NA hsa-miR-30c-5p SOCS1 -0.393222674580066 8.06961465717306e-05 0.463525464851224 0.00255751332764507 miRNAWalker2_validate -0.205832448346325 9.76302739998273e-05 NA NA NA hsa-miR-331-3p SOCS1 0.74441480542886 1.17071235477799e-07 0.463525464851224 0.00255751332764507 PITA -0.167049711087857 7.01723482455041e-06 NA NA NA hsa-miR-107 SOCS2 0.678998026350662 2.56224148930538e-16 -1.85803882323019 1.27461377734762e-27 miRanda -0.357619634378991 6.32055929228e-07 NA NA NA hsa-miR-130b-5p SOCS2 1.0573161199584 2.55177349228739e-12 -1.85803882323019 1.27461377734762e-27 miRNATAP -0.442856401715022 3.02899724047706e-31 NA NA NA hsa-miR-16-1-3p SOCS2 1.30142784811196 2.53343713753744e-29 -1.85803882323019 1.27461377734762e-27 mirMAP -0.57115230568011 2.81327163820674e-28 NA NA NA hsa-miR-16-5p SOCS2 0.46835991343556 1.91125356547776e-06 -1.85803882323019 1.27461377734762e-27 miRNAWalker2_validate -0.564883821067525 4.7377525222011e-21 NA NA NA hsa-miR-186-5p SOCS2 -0.426987301460247 1.04129380549315e-05 -1.85803882323019 1.27461377734762e-27 mirMAP -0.225681674680643 0.000295473236517463 NA NA NA hsa-miR-194-5p SOCS2 0.467781870340114 1.0386810618625e-07 -1.85803882323019 1.27461377734762e-27 miRNAWalker2_validate;miRTarBase;miRNATAP -0.267533169196439 9.55649717737723e-05 22102710 Functional studies indicated that CDKN1A/p21 and SOCS2 expression is directly regulated by miR-20a/-20b and miR-194 respectively; miR-20a/b and miR-194 target CDKN1A and SOCS2 in follicular lymphoma potentially contributing to tumor cell proliferation and survival poor survival lymphoma hsa-miR-19a-3p SOCS2 0.817507952171848 3.76285090469625e-08 -1.85803882323019 1.27461377734762e-27 mirMAP -0.297964706606913 7.48780927063011e-14 NA NA NA hsa-miR-19b-3p SOCS2 0.139124391010031 0.255658553872934 -1.85803882323019 1.27461377734762e-27 mirMAP -0.209801527647616 2.16913110480789e-05 NA NA NA hsa-miR-20a-3p SOCS2 -0.218902047543766 0.179868363625547 -1.85803882323019 1.27461377734762e-27 miRNATAP -0.175538607773565 2.14385131546956e-06 NA NA NA hsa-miR-32-5p SOCS2 1.38676603945192 2.29428299685976e-34 -1.85803882323019 1.27461377734762e-27 mirMAP -0.331162292558335 6.59830080590599e-11 NA NA NA hsa-miR-320b SOCS2 0.412787504747938 0.00113457276903985 -1.85803882323019 1.27461377734762e-27 miRanda -0.338842656804501 8.00699810186314e-13 NA NA NA hsa-miR-324-5p SOCS2 0.211552647440779 0.139408130311654 -1.85803882323019 1.27461377734762e-27 miRanda -0.388085632924069 5.89601551540041e-21 NA NA NA hsa-miR-342-3p SOCS2 1.21944481975657 6.81914373001202e-19 -1.85803882323019 1.27461377734762e-27 miRanda -0.131773960458645 0.00223324523415912 NA NA NA hsa-miR-429 SOCS2 2.84108892259147 3.88520896426515e-64 -1.85803882323019 1.27461377734762e-27 miRNATAP -0.310745479572776 1.65061889897108e-21 NA NA NA hsa-miR-500a-3p SOCS2 0.139523673241448 0.185528510741158 -1.85803882323019 1.27461377734762e-27 miRNATAP -0.254353011998127 9.48308269853222e-06 NA NA NA hsa-miR-576-5p SOCS2 0.0649387707567879 0.588791966096287 -1.85803882323019 1.27461377734762e-27 PITA -0.300052538198281 2.10228687690628e-09 NA NA NA hsa-miR-590-3p SOCS2 1.27438512890514 1.03164723481469e-23 -1.85803882323019 1.27461377734762e-27 mirMAP -0.473055947710998 1.22163673986208e-23 NA NA NA hsa-miR-7-1-3p SOCS2 0.686579567507582 1.20731554448806e-07 -1.85803882323019 1.27461377734762e-27 mirMAP -0.298254471745365 8.0797125582583e-11 NA NA NA hsa-miR-130b-5p SOCS3 1.0573161199584 2.55177349228739e-12 -1.29575989227768 3.54713025718723e-20 mirMAP -0.166040607080379 2.36775819781641e-07 NA NA NA hsa-miR-193a-3p SOCS3 0.310617999804917 0.00477640270974957 -1.29575989227768 3.54713025718723e-20 miRanda -0.162739698070637 0.000291015578994681 NA NA NA hsa-miR-629-3p SOCS3 1.25035919247365 3.91361135469024e-14 -1.29575989227768 3.54713025718723e-20 mirMAP -0.205531995547468 8.4599583683451e-12 NA NA NA hsa-miR-629-5p SOCS3 0.42411327890895 2.46262300605706e-05 -1.29575989227768 3.54713025718723e-20 mirMAP -0.158418317519696 0.00126187826356768 NA NA NA hsa-let-7i-5p SOCS4 -0.333419326258177 3.56960810786801e-08 -0.143989252326499 0.0178365006032023 miRNATAP -0.112733387018692 0.00113632977070114 NA NA NA hsa-miR-140-3p SOCS4 -1.25844395244141 5.29222651039892e-33 -0.143989252326499 0.0178365006032023 PITA;miRNATAP -0.144398542328187 1.43891980642266e-14 NA NA NA hsa-miR-374a-5p SOCS4 -0.239709888246804 0.00309819667153627 -0.143989252326499 0.0178365006032023 mirMAP -0.101408273577265 8.32011878639527e-05 NA NA NA hsa-miR-455-5p SOCS4 0.284641224662773 0.0357572339594277 -0.143989252326499 0.0178365006032023 miRanda -0.128586525140981 1.47016670131224e-17 NA NA NA hsa-miR-107 SOCS5 0.678998026350662 2.56224148930538e-16 -0.851523736382883 3.15353102501472e-34 miRanda -0.291453750556477 7.06941829143606e-24 NA NA NA hsa-miR-141-3p SOCS5 2.99777540204168 1.26370498493024e-78 -0.851523736382883 3.15353102501472e-34 TargetScan -0.114841074509222 1.33359357804587e-16 NA NA NA hsa-miR-21-5p SOCS5 2.32007501846389 3.08394781855554e-137 -0.851523736382883 3.15353102501472e-34 miRNAWalker2_validate -0.252298585835556 7.63709510228412e-31 NA NA NA hsa-miR-340-5p SOCS5 1.0857159627596 4.94471062546756e-24 -0.851523736382883 3.15353102501472e-34 mirMAP -0.195527671581348 1.18451645285982e-18 NA NA NA hsa-miR-342-3p SOCS5 1.21944481975657 6.81914373001202e-19 -0.851523736382883 3.15353102501472e-34 miRanda -0.11078314614982 3.09634805849783e-10 NA NA NA hsa-miR-429 SOCS5 2.84108892259147 3.88520896426515e-64 -0.851523736382883 3.15353102501472e-34 miRanda -0.105156285793856 8.96506825888405e-15 NA NA NA hsa-miR-107 SOCS7 0.678998026350662 2.56224148930538e-16 -0.880052915807183 2.43072924055549e-10 miRNATAP -0.164504415662425 0.00418692131574651 NA NA NA hsa-miR-320a SOCS7 -0.287921276129346 0.00141693637596294 -0.880052915807183 2.43072924055549e-10 PITA;miRanda -0.196805095279909 0.000234442612306508 NA NA NA hsa-miR-96-5p SOCS7 3.24596558166606 1.92296159041707e-98 -0.880052915807183 2.43072924055549e-10 TargetScan -0.115765157011558 2.92871573800537e-05 NA NA NA hsa-miR-107 SOS1 0.678998026350662 2.56224148930538e-16 -0.877855751541721 1.03695500778597e-32 miRNATAP -0.147394654065725 2.31192726053177e-06 NA NA NA hsa-miR-16-1-3p SOS1 1.30142784811196 2.53343713753744e-29 -0.877855751541721 1.03695500778597e-32 mirMAP -0.107043157753765 3.80189774791566e-06 NA NA NA hsa-miR-181a-5p SOS1 0.635863607630183 6.72486918157744e-11 -0.877855751541721 1.03695500778597e-32 MirTarget;miRNATAP -0.159742255037842 1.79079079153389e-09 NA NA NA hsa-miR-181b-5p SOS1 1.22749257795094 1.21998198830919e-27 -0.877855751541721 1.03695500778597e-32 MirTarget;miRNATAP -0.145535984933139 7.83280749467566e-11 NA NA NA hsa-miR-181c-5p SOS1 0.574847839298605 4.51287502066478e-07 -0.877855751541721 1.03695500778597e-32 MirTarget;miRNATAP -0.128681631990538 1.68288122680838e-08 NA NA NA hsa-miR-181d-5p SOS1 0.782618466877349 1.2821116358212e-09 -0.877855751541721 1.03695500778597e-32 MirTarget -0.116569643832434 6.10109884911499e-09 NA NA NA hsa-miR-182-5p SOS1 2.36408084103818 2.60011457600281e-72 -0.877855751541721 1.03695500778597e-32 miRNATAP -0.133258609259375 1.37594627633909e-13 NA NA NA hsa-miR-361-5p SOS1 -0.0996867547900457 0.095428250126326 -0.877855751541721 1.03695500778597e-32 miRanda -0.165292469967548 0.000212244095536951 NA NA NA hsa-miR-429 SOS1 2.84108892259147 3.88520896426515e-64 -0.877855751541721 1.03695500778597e-32 miRanda;miRNATAP -0.114619423820961 9.86568637608249e-16 NA NA NA hsa-miR-542-3p SOS1 0.568822103820889 8.5699075257651e-07 -0.877855751541721 1.03695500778597e-32 miRanda -0.156663695721104 2.52964146595814e-12 NA NA NA hsa-miR-96-5p SOS1 3.24596558166606 1.92296159041707e-98 -0.877855751541721 1.03695500778597e-32 TargetScan;miRNATAP -0.114957974727393 1.33288008849377e-14 NA NA NA hsa-miR-130b-3p SOS2 1.38122163823846 1.00932179737836e-26 -0.693584357428233 2.85648006434693e-23 miRNATAP -0.109371088184118 2.82016388666753e-09 NA NA NA hsa-miR-146b-5p SOS2 0.631041661167954 6.20366593452965e-08 -0.693584357428233 2.85648006434693e-23 miRanda -0.18410115041905 2.89003141851973e-19 NA NA NA hsa-miR-15a-5p SOS2 0.812445324157528 4.50263417099822e-20 -0.693584357428233 2.85648006434693e-23 miRNATAP -0.260459131538532 1.04889039594078e-22 NA NA NA hsa-miR-21-5p SOS2 2.32007501846389 3.08394781855554e-137 -0.693584357428233 2.85648006434693e-23 miRNATAP -0.267389788495656 7.45996997519246e-36 NA NA NA hsa-miR-103a-3p SPRED1 0.610673390034345 1.63113920514646e-12 -0.73987992932487 1.32055673934219e-15 miRNAWalker2_validate -0.399868915081714 6.22870878434833e-29 NA NA NA hsa-miR-106b-5p SPRED1 1.22477789913175 2.31787213143326e-32 -0.73987992932487 1.32055673934219e-15 miRNATAP -0.227691950472946 1.61287945639529e-14 NA NA NA hsa-miR-107 SPRED1 0.678998026350662 2.56224148930538e-16 -0.73987992932487 1.32055673934219e-15 miRanda -0.315000387449304 8.03619419901627e-17 NA NA NA hsa-miR-141-3p SPRED1 2.99777540204168 1.26370498493024e-78 -0.73987992932487 1.32055673934219e-15 miRNATAP -0.161162915971162 2.35918858864777e-19 NA NA NA hsa-miR-15a-5p SPRED1 0.812445324157528 4.50263417099822e-20 -0.73987992932487 1.32055673934219e-15 miRNATAP -0.283988550353541 7.3998535134395e-16 NA NA NA hsa-miR-16-1-3p SPRED1 1.30142784811196 2.53343713753744e-29 -0.73987992932487 1.32055673934219e-15 mirMAP -0.143254002135989 4.65640837863334e-07 NA NA NA hsa-miR-183-5p SPRED1 2.95681814393872 1.09965777344285e-92 -0.73987992932487 1.32055673934219e-15 miRNATAP -0.175824540066669 1.36831923795005e-19 NA NA NA hsa-miR-194-5p SPRED1 0.467781870340114 1.0386810618625e-07 -0.73987992932487 1.32055673934219e-15 miRNATAP -0.144803147932375 7.5566668425542e-05 NA NA NA hsa-miR-200a-3p SPRED1 2.55218480823434 2.96135446816238e-51 -0.73987992932487 1.32055673934219e-15 miRNATAP -0.131532261379301 1.11338813569557e-13 NA NA NA hsa-miR-200b-3p SPRED1 2.11744072703209 1.66710572104191e-43 -0.73987992932487 1.32055673934219e-15 TargetScan -0.142284251884432 5.32725114828085e-13 NA NA NA hsa-miR-200c-3p SPRED1 2.07038651806183 6.84613386286599e-51 -0.73987992932487 1.32055673934219e-15 miRNATAP -0.191613645318991 5.16049176566749e-19 NA NA NA hsa-miR-20a-5p SPRED1 0.44979911120222 0.000602386964327228 -0.73987992932487 1.32055673934219e-15 miRNATAP -0.130757031255072 8.79502383042445e-08 NA NA NA hsa-miR-25-3p SPRED1 -0.00546790775985073 0.944061771389468 -0.73987992932487 1.32055673934219e-15 mirMAP -0.118585366864714 0.00458142378464949 NA NA NA hsa-miR-301a-3p SPRED1 1.32170168375632 2.12280368957514e-15 -0.73987992932487 1.32055673934219e-15 miRNATAP -0.120059208220864 2.59072098618985e-10 NA NA NA hsa-miR-32-5p SPRED1 1.38676603945192 2.29428299685976e-34 -0.73987992932487 1.32055673934219e-15 mirMAP -0.127509242219405 2.82789058422961e-06 NA NA NA hsa-miR-340-5p SPRED1 1.0857159627596 4.94471062546756e-24 -0.73987992932487 1.32055673934219e-15 mirMAP -0.173480805147389 2.43042877011631e-09 NA NA NA hsa-miR-361-5p SPRED1 -0.0996867547900457 0.095428250126326 -0.73987992932487 1.32055673934219e-15 miRanda -0.195276033485261 0.000370633823876421 NA NA NA hsa-miR-429 SPRED1 2.84108892259147 3.88520896426515e-64 -0.73987992932487 1.32055673934219e-15 miRNATAP -0.134717920033516 1.76188718637229e-14 NA NA NA hsa-miR-454-3p SPRED1 1.28177672191095 6.84024979484587e-21 -0.73987992932487 1.32055673934219e-15 miRNATAP -0.147674732546485 1.30721674813999e-10 NA NA NA hsa-miR-93-5p SPRED1 1.01788600209314 1.24312921618126e-21 -0.73987992932487 1.32055673934219e-15 miRNAWalker2_validate;miRNATAP -0.279007271272231 4.64590533451536e-22 NA NA NA hsa-miR-106b-5p SPRED2 1.22477789913175 2.31787213143326e-32 -0.139316049118136 0.134576350255528 mirMAP -0.257391732700684 9.86608041381604e-19 NA NA NA hsa-miR-140-3p SPRED2 -1.25844395244141 5.29222651039892e-33 -0.139316049118136 0.134576350255528 PITA;miRNATAP -0.180133673011083 4.86830423048208e-10 NA NA NA hsa-miR-142-5p SPRED2 1.16509303143593 1.96641162209073e-13 -0.139316049118136 0.134576350255528 mirMAP -0.137148364454279 2.49596386273294e-12 NA NA NA hsa-miR-146b-5p SPRED2 0.631041661167954 6.20366593452965e-08 -0.139316049118136 0.134576350255528 miRanda -0.255299367563932 6.59294141377372e-22 NA NA NA hsa-miR-17-3p SPRED2 0.721439431208839 7.95900548819742e-10 -0.139316049118136 0.134576350255528 miRNATAP -0.318200033800497 7.79931198337989e-35 NA NA NA hsa-miR-17-5p SPRED2 0.599531757298529 1.07318660415906e-05 -0.139316049118136 0.134576350255528 mirMAP -0.220208675621974 3.59625833373277e-22 NA NA NA hsa-miR-186-5p SPRED2 -0.426987301460247 1.04129380549315e-05 -0.139316049118136 0.134576350255528 miRNAWalker2_validate -0.143907894061877 1.15148917269015e-05 NA NA NA hsa-miR-20a-5p SPRED2 0.44979911120222 0.000602386964327228 -0.139316049118136 0.134576350255528 mirMAP -0.258239807889173 4.34651520899921e-28 NA NA NA hsa-miR-320a SPRED2 -0.287921276129346 0.00141693637596294 -0.139316049118136 0.134576350255528 PITA;miRanda;miRNATAP -0.139229612469426 8.3665966938384e-05 NA NA NA hsa-miR-320b SPRED2 0.412787504747938 0.00113457276903985 -0.139316049118136 0.134576350255528 PITA;miRanda;miRNATAP -0.121312321594632 1.40441751481348e-06 NA NA NA hsa-miR-340-5p SPRED2 1.0857159627596 4.94471062546756e-24 -0.139316049118136 0.134576350255528 miRNATAP -0.165708038103055 8.1458000026646e-09 NA NA NA hsa-miR-362-5p SPRED2 -0.248676340901797 0.0726089851456282 -0.139316049118136 0.134576350255528 PITA -0.24561278656555 3.05963799994026e-28 NA NA NA hsa-miR-500a-5p SPRED2 0.209805801129289 0.119177819862398 -0.139316049118136 0.134576350255528 mirMAP -0.25852608278386 9.67752615941468e-29 NA NA NA hsa-miR-532-5p SPRED2 0.0386976222860582 0.682018574136515 -0.139316049118136 0.134576350255528 PITA -0.349005273605807 3.14349634337146e-26 NA NA NA hsa-miR-590-5p SPRED2 0.746515607868274 8.51300479640125e-09 -0.139316049118136 0.134576350255528 miRanda -0.138864570006663 1.02532669333867e-08 NA NA NA hsa-miR-93-5p SPRED2 1.01788600209314 1.24312921618126e-21 -0.139316049118136 0.134576350255528 mirMAP -0.2748749787398 6.01521246537638e-22 NA NA NA hsa-let-7a-3p SPRY1 0.466622567891891 3.70886257943079e-07 -2.02456512680151 4.17071179941854e-56 miRNATAP -0.377332418892819 9.29010064029327e-14 NA NA NA hsa-miR-107 SPRY1 0.678998026350662 2.56224148930538e-16 -2.02456512680151 4.17071179941854e-56 miRanda;miRNATAP -0.465634785938433 3.5766289327099e-17 NA NA NA hsa-miR-16-2-3p SPRY1 0.286355254959005 0.0256946046884474 -2.02456512680151 4.17071179941854e-56 mirMAP -0.289934774072601 1.79225689877757e-15 NA NA NA hsa-miR-20a-3p SPRY1 -0.218902047543766 0.179868363625547 -2.02456512680151 4.17071179941854e-56 miRNATAP -0.143857440984363 6.30684474087351e-07 NA NA NA hsa-miR-21-5p SPRY1 2.32007501846389 3.08394781855554e-137 -2.02456512680151 4.17071179941854e-56 miRNATAP -0.446564917887034 6.78372597097293e-27 24155920 Functional studies showed that miR-21 over-expression in GICs induced comparable cell differentiation features and targeted SPRY1 mRNA which encodes for a negative regulator of neural stem-cell differentiation differentiation glioblastoma hsa-miR-29b-3p SPRY1 0.438847962603729 6.46722433236121e-05 -2.02456512680151 4.17071179941854e-56 miRNATAP -0.326332632516663 1.19572430807317e-14 NA NA NA hsa-miR-324-3p SPRY1 0.404877731996915 0.000340036423920834 -2.02456512680151 4.17071179941854e-56 miRNAWalker2_validate -0.395646345913053 2.5459540077668e-22 NA NA NA hsa-miR-339-5p SPRY1 -0.211548290465418 0.0685885445822389 -2.02456512680151 4.17071179941854e-56 miRanda -0.178416334989961 1.10633966030178e-05 NA NA NA hsa-miR-455-3p SPRY1 0.678392920628872 0.000327758844555877 -2.02456512680151 4.17071179941854e-56 miRNATAP -0.184692113348685 5.34118843099961e-14 NA NA NA hsa-miR-590-5p SPRY1 0.746515607868274 8.51300479640125e-09 -2.02456512680151 4.17071179941854e-56 PITA;miRanda;miRNATAP -0.328262184408038 1.55809183032463e-20 NA NA NA hsa-miR-98-5p SPRY1 0.656336869298973 9.03113188590466e-15 -2.02456512680151 4.17071179941854e-56 miRNAWalker2_validate -0.463322674825321 1.17075321698728e-17 NA NA NA hsa-let-7a-3p SPRY2 0.466622567891891 3.70886257943079e-07 -2.72906279183225 4.36360171627142e-90 miRNATAP -0.223841171257635 7.55380612405272e-05 NA NA NA hsa-miR-148a-3p SPRY2 0.706969798912638 5.52538085480485e-09 -2.72906279183225 4.36360171627142e-90 miRNAWalker2_validate -0.126653600704164 0.00298006995693874 NA NA NA hsa-miR-181a-5p SPRY2 0.635863607630183 6.72486918157744e-11 -2.72906279183225 4.36360171627142e-90 miRNAWalker2_validate -0.236448778415776 7.84615623712276e-06 NA NA NA hsa-miR-21-5p SPRY2 2.32007501846389 3.08394781855554e-137 -2.72906279183225 4.36360171627142e-90 miRNAWalker2_validate;miRTarBase;miRNATAP -0.684722889689909 7.12948810098069e-54 22322462 Inhibition of microRNA-21 mir‑21 induced upregulation of Spry2 and PTEN which underscores the importance of mir-21 in Spry2-associated tumorigenesis of the colon tumorigenesis colon cancer hsa-miR-330-5p SPRY2 0.626063225953928 3.42215028606779e-09 -2.72906279183225 4.36360171627142e-90 miRanda;miRNATAP -0.331174994713037 7.23637017911274e-12 NA NA NA hsa-miR-429 SPRY2 2.84108892259147 3.88520896426515e-64 -2.72906279183225 4.36360171627142e-90 miRanda -0.370395879934324 8.88044596656627e-42 NA NA NA hsa-miR-590-3p SPRY2 1.27438512890514 1.03164723481469e-23 -2.72906279183225 4.36360171627142e-90 PITA;miRanda;mirMAP;miRNATAP -0.343285307851214 5.68372674302789e-17 NA NA NA hsa-miR-590-5p SPRY2 0.746515607868274 8.51300479640125e-09 -2.72906279183225 4.36360171627142e-90 PITA;miRanda;miRNATAP -0.195337240970435 8.73594803853544e-07 NA NA NA hsa-miR-141-3p SPRY3 2.99777540204168 1.26370498493024e-78 -0.743897577510337 8.22794586143845e-18 mirMAP -0.108375435062231 1.80222465712053e-10 NA NA NA hsa-miR-182-5p SPRY3 2.36408084103818 2.60011457600281e-72 -0.743897577510337 8.22794586143845e-18 mirMAP -0.139048934279916 2.34503167156917e-11 NA NA NA hsa-miR-200a-3p SPRY3 2.55218480823434 2.96135446816238e-51 -0.743897577510337 8.22794586143845e-18 mirMAP -0.106245731360012 1.86180122777501e-10 NA NA NA hsa-miR-200b-3p SPRY3 2.11744072703209 1.66710572104191e-43 -0.743897577510337 8.22794586143845e-18 mirMAP -0.116765535305546 3.07731809687366e-10 NA NA NA hsa-miR-200c-3p SPRY3 2.07038651806183 6.84613386286599e-51 -0.743897577510337 8.22794586143845e-18 mirMAP -0.127854270188269 3.67091697628272e-10 NA NA NA hsa-miR-21-3p SPRY3 2.17476065946878 5.15299442583591e-75 -0.743897577510337 8.22794586143845e-18 mirMAP -0.102159363784401 1.02696914909014e-05 NA NA NA hsa-miR-96-5p SPRY3 3.24596558166606 1.92296159041707e-98 -0.743897577510337 8.22794586143845e-18 MirTarget;TargetScan -0.112857949131037 6.43649140897643e-11 NA NA NA hsa-miR-106b-5p SPRY4 1.22477789913175 2.31787213143326e-32 -0.269797609928706 0.00344671028336406 miRNATAP -0.13418882649319 5.01532884039926e-06 NA NA NA hsa-miR-141-3p SPRY4 2.99777540204168 1.26370498493024e-78 -0.269797609928706 0.00344671028336406 TargetScan;miRNATAP -0.136262756960658 1.26981399486428e-14 NA NA NA hsa-miR-15a-5p SPRY4 0.812445324157528 4.50263417099822e-20 -0.269797609928706 0.00344671028336406 miRNATAP -0.11466840940611 0.00108153241743053 NA NA NA hsa-miR-17-5p SPRY4 0.599531757298529 1.07318660415906e-05 -0.269797609928706 0.00344671028336406 TargetScan;miRNATAP -0.128049440841921 2.56083139973677e-08 NA NA NA hsa-miR-181c-5p SPRY4 0.574847839298605 4.51287502066478e-07 -0.269797609928706 0.00344671028336406 miRNATAP -0.117820178519481 1.9474366993238e-05 NA NA NA hsa-miR-200a-3p SPRY4 2.55218480823434 2.96135446816238e-51 -0.269797609928706 0.00344671028336406 mirMAP;miRNATAP -0.135104834299242 6.51393438180949e-15 NA NA NA hsa-miR-20a-5p SPRY4 0.44979911120222 0.000602386964327228 -0.269797609928706 0.00344671028336406 miRNATAP -0.151245096819524 2.39969842211597e-10 NA NA NA hsa-miR-29b-3p SPRY4 0.438847962603729 6.46722433236121e-05 -0.269797609928706 0.00344671028336406 miRNATAP -0.130200997535324 5.64212359807336e-06 NA NA NA hsa-miR-320a SPRY4 -0.287921276129346 0.00141693637596294 -0.269797609928706 0.00344671028336406 mirMAP -0.128662355466235 0.000252136284720283 NA NA NA hsa-miR-361-3p SPRY4 -0.0370446538644886 0.624902392829872 -0.269797609928706 0.00344671028336406 miRNATAP -0.248309146284165 3.01092432755772e-09 NA NA NA hsa-miR-429 SPRY4 2.84108892259147 3.88520896426515e-64 -0.269797609928706 0.00344671028336406 miRanda -0.124670922388077 5.08890882170263e-13 NA NA NA hsa-miR-93-5p SPRY4 1.01788600209314 1.24312921618126e-21 -0.269797609928706 0.00344671028336406 miRNATAP -0.173206528789985 1.82244998213186e-09 NA NA NA hsa-miR-361-5p STAM -0.0996867547900457 0.095428250126326 0.125006109999592 0.0291178748506363 miRanda -0.151114271798293 5.38584230083176e-06 NA NA NA hsa-miR-107 STAM2 0.678998026350662 2.56224148930538e-16 -0.239491266060292 0.000268618307154935 miRanda -0.25218544497314 7.2787235612735e-22 NA NA NA hsa-miR-146b-5p STAM2 0.631041661167954 6.20366593452965e-08 -0.239491266060292 0.000268618307154935 miRanda -0.194460095623392 2.32011746556315e-25 NA NA NA hsa-miR-25-3p STAM2 -0.00546790775985073 0.944061771389468 -0.239491266060292 0.000268618307154935 mirMAP -0.272660978740626 1.17067254687687e-21 NA NA NA hsa-miR-32-5p STAM2 1.38676603945192 2.29428299685976e-34 -0.239491266060292 0.000268618307154935 mirMAP -0.118665300149298 3.62111868319519e-10 NA NA NA hsa-miR-361-5p STAM2 -0.0996867547900457 0.095428250126326 -0.239491266060292 0.000268618307154935 miRanda -0.309290261814999 2.38531436750958e-16 NA NA NA hsa-miR-455-5p STAM2 0.284641224662773 0.0357572339594277 -0.239491266060292 0.000268618307154935 miRanda -0.207094617024343 8.27315519656952e-39 NA NA NA hsa-miR-92a-3p STAM2 -0.342420481092807 0.000732275969501111 -0.239491266060292 0.000268618307154935 mirMAP -0.209374707933065 5.75009825602305e-22 NA NA NA hsa-miR-10b-3p STAT1 -1.58463104907636 1.17335119858099e-46 0.84704946611897 1.52503088632031e-12 mirMAP -0.189779738418485 8.48221031689475e-08 NA NA NA hsa-miR-145-5p STAT1 -2.62703571936687 7.64402900188551e-88 0.84704946611897 1.52503088632031e-12 miRNAWalker2_validate;miRTarBase -0.190431855359047 8.49731192294897e-12 20098684 MicroRNA 145 targets YES and STAT1 in colon cancer cells; Both YES and STAT1 were verified as direct miR-145 targets colon cancer hsa-miR-30c-2-3p STAT1 -0.793306601708467 2.88673428932496e-07 0.84704946611897 1.52503088632031e-12 MirTarget -0.260934621334273 1.15901234049689e-23 NA NA NA hsa-miR-361-5p STAT1 -0.0996867547900457 0.095428250126326 0.84704946611897 1.52503088632031e-12 miRanda -0.307010691916702 1.36430849398455e-05 NA NA NA hsa-miR-495-3p STAT1 -1.67685437612894 1.70634429769052e-34 0.84704946611897 1.52503088632031e-12 MirTarget -0.121713123631323 3.00343012625224e-05 NA NA NA hsa-let-7a-5p STAT2 -0.210286642041636 0.0072546234707717 0.0993455211070939 0.0648398944148537 MirTarget -0.106514425669648 6.19269607723708e-06 NA NA NA hsa-miR-106b-5p STAT3 1.22477789913175 2.31787213143326e-32 -0.0795719313844554 0.196002766536761 miRNATAP -0.131970087889985 1.02322360493683e-11 27325313 We also found that EMMPRIN could down-regulate miR-106a and miR-106b expression in breast cancer cells which led to activating STAT3 and enhancing HIF-1α expression breast cancer hsa-miR-93-5p STAT3 1.01788600209314 1.24312921618126e-21 -0.0795719313844554 0.196002766536761 miRNAWalker2_validate;miRNATAP -0.10971954684391 1.03930358188952e-08 NA NA NA hsa-miR-125a-5p STAT4 -0.635694700253268 3.6703235721638e-11 -0.980704169210314 7.75895883125847e-09 miRanda -0.26608848558262 1.09700237808341e-05 NA NA NA hsa-miR-141-3p STAT4 2.99777540204168 1.26370498493024e-78 -0.980704169210314 7.75895883125847e-09 MirTarget;TargetScan -0.240950533860277 2.29630203380521e-13 24732377 Down regulation of miR 141 induced by helicobacter pylori promotes the invasion of gastric cancer by targeting STAT4; A luciferase assay revealed that miR-141 was directly bound to the 3'-untranslated regions 3'-UTR of STAT4; Over-expression of STAT4 was used to mimic miR-141 action in the invasion of gastric cancer; MiR-141 may play a pivotal role in controlling gastric cancer invasion through regulating STAT4 and maybe a potential target to treat gastric cancer gastric cancer hsa-miR-200a-3p STAT4 2.55218480823434 2.96135446816238e-51 -0.980704169210314 7.75895883125847e-09 MirTarget -0.213924427791527 3.73823510549369e-11 NA NA NA hsa-miR-29b-2-5p STAT4 -0.263499971180298 0.0400001755611965 -0.980704169210314 7.75895883125847e-09 MirTarget -0.276198221785735 1.23399050696674e-09 NA NA NA hsa-miR-141-3p STAT5A 2.99777540204168 1.26370498493024e-78 -1.42714993428393 2.70689276768275e-43 MirTarget;TargetScan;miRNATAP -0.249467858863614 1.60720902974445e-34 25241899 Progesterone downregulation of miR 141 contributes to expansion of stem like breast cancer cells through maintenance of progesterone receptor and Stat5a; miR-141 directly targeted both PR and signal transducer and activator of transcription 5A Stat5a transcription factors important for MaSC expansion; These data support a mechanism by which P4-triggered loss of miR-141 facilitates breast cancer cell de-differentiation through deregulation of PR and Stat5a two transcription factors important for controlling mammary cell fate differentiation breast cancer hsa-miR-141-5p STAT5A 2.38411349683216 4.56310582620282e-58 -1.42714993428393 2.70689276768275e-43 MirTarget -0.274131311316507 3.92901446864404e-34 25241899 Progesterone downregulation of miR 141 contributes to expansion of stem like breast cancer cells through maintenance of progesterone receptor and Stat5a; miR-141 directly targeted both PR and signal transducer and activator of transcription 5A Stat5a transcription factors important for MaSC expansion; These data support a mechanism by which P4-triggered loss of miR-141 facilitates breast cancer cell de-differentiation through deregulation of PR and Stat5a two transcription factors important for controlling mammary cell fate differentiation breast cancer hsa-miR-200a-3p STAT5A 2.55218480823434 2.96135446816238e-51 -1.42714993428393 2.70689276768275e-43 MirTarget;miRNATAP -0.17649399523056 5.36082676998248e-18 NA NA NA hsa-miR-141-3p STAT5B 2.99777540204168 1.26370498493024e-78 -1.26603570026736 3.18742679965819e-62 MirTarget;TargetScan;miRNATAP -0.210194932545999 8.1601418441609e-44 NA NA NA hsa-miR-185-3p STAT5B 0.86591374114446 7.8790769678542e-10 -1.26603570026736 3.18742679965819e-62 MirTarget -0.106009928199188 1.18746806636768e-07 NA NA NA hsa-miR-194-5p STAT5B 0.467781870340114 1.0386810618625e-07 -1.26603570026736 3.18742679965819e-62 miRNATAP -0.122789240886661 0.000120774595899818 NA NA NA hsa-miR-200a-3p STAT5B 2.55218480823434 2.96135446816238e-51 -1.26603570026736 3.18742679965819e-62 MirTarget;miRNATAP -0.166364658066859 5.40700398258099e-28 NA NA NA hsa-miR-21-3p STAT5B 2.17476065946878 5.15299442583591e-75 -1.26603570026736 3.18742679965819e-62 MirTarget -0.265425490688425 9.56942391027435e-38 NA NA NA hsa-miR-590-3p STAT5B 1.27438512890514 1.03164723481469e-23 -1.26603570026736 3.18742679965819e-62 miRanda -0.171886429443684 1.10254290509012e-14 NA NA NA hsa-miR-93-3p STAT5B 0.627759242044891 3.62527588304617e-06 -1.26603570026736 3.18742679965819e-62 miRNAWalker2_validate -0.123045428603394 2.04636689612631e-09 NA NA NA hsa-miR-590-3p STAT6 1.27438512890514 1.03164723481469e-23 -0.421696502744889 4.34686233672539e-10 miRanda -0.130328498185836 1.87740007215643e-12 NA NA NA hsa-miR-590-5p STAT6 0.746515607868274 8.51300479640125e-09 -0.421696502744889 4.34686233672539e-10 miRanda -0.152341163984789 3.9482775090835e-18 NA NA NA hsa-miR-125a-3p TPO -0.176412960953959 0.10108079286419 -3.48758624568925 1.40354343297472e-53 miRanda -0.308187783580639 6.85266583407388e-05 NA NA NA hsa-miR-130b-5p TPO 1.0573161199584 2.55177349228739e-12 -3.48758624568925 1.40354343297472e-53 mirMAP -0.766494689701318 3.51071339019858e-51 NA NA NA hsa-miR-19a-3p TPO 0.817507952171848 3.76285090469625e-08 -3.48758624568925 1.40354343297472e-53 mirMAP -0.559118875196077 3.0279485631128e-25 NA NA NA hsa-miR-19b-3p TPO 0.139124391010031 0.255658553872934 -3.48758624568925 1.40354343297472e-53 mirMAP -0.491999783472377 2.25411721959335e-13 NA NA NA hsa-miR-25-3p TPO -0.00546790775985073 0.944061771389468 -3.48758624568925 1.40354343297472e-53 mirMAP -0.415608838436136 0.000108385867415965 NA NA NA hsa-miR-29a-5p TPO 0.334183773952055 0.00445137265870197 -3.48758624568925 1.40354343297472e-53 mirMAP -0.49778286519217 1.17710837878376e-12 NA NA NA hsa-miR-30d-3p TPO 0.264544633563642 0.00755023189129747 -3.48758624568925 1.40354343297472e-53 mirMAP -0.488781694945213 4.85443953983284e-09 NA NA NA hsa-miR-32-5p TPO 1.38676603945192 2.29428299685976e-34 -3.48758624568925 1.40354343297472e-53 mirMAP -0.667954740796978 1.96585505972057e-22 NA NA NA hsa-miR-590-3p TPO 1.27438512890514 1.03164723481469e-23 -3.48758624568925 1.40354343297472e-53 miRanda -0.738389550833935 1.26901207865849e-30 NA NA NA hsa-miR-615-3p TPO 0.659240580933614 0.000360214386152507 -3.48758624568925 1.40354343297472e-53 miRanda -0.229706673021997 2.58311586874384e-07 NA NA NA hsa-miR-7-1-3p TPO 0.686579567507582 1.20731554448806e-07 -3.48758624568925 1.40354343297472e-53 mirMAP -0.48176422202225 1.50934472130454e-14 NA NA NA hsa-miR-92a-3p TPO -0.342420481092807 0.000732275969501111 -3.48758624568925 1.40354343297472e-53 mirMAP -0.657521183537481 3.47253077597659e-16 NA NA NA hsa-miR-92b-3p TPO 1.30248132773644 9.42428674470985e-25 -3.48758624568925 1.40354343297472e-53 mirMAP -0.600939240810753 3.61901318338409e-22 NA NA NA hsa-let-7a-3p TSLP 0.466622567891891 3.70886257943079e-07 -4.19406426017112 3.96277915090534e-71 MirTarget -0.474282445463471 6.91585668073145e-07 NA NA NA hsa-let-7f-1-3p TSLP 0.37532726250321 0.00156021688753682 -4.19406426017112 3.96277915090534e-71 MirTarget -0.262792032240764 0.00048113645793617 NA NA NA hsa-miR-142-3p TSLP 1.53951237846104 2.06769936282034e-17 -4.19406426017112 3.96277915090534e-71 miRanda -0.238892684356061 4.71518233791653e-07 NA NA NA hsa-miR-340-5p TSLP 1.0857159627596 4.94471062546756e-24 -4.19406426017112 3.96277915090534e-71 mirMAP -0.341085678481602 1.96395761414172e-05 NA NA NA hsa-miR-590-3p TSLP 1.27438512890514 1.03164723481469e-23 -4.19406426017112 3.96277915090534e-71 miRanda;mirMAP -0.512260861591671 2.14698385760537e-13 NA NA NA