miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-15b-5p AATK 0.251826642099145 0.790709218602499 0.00366137231187924 0.992434238880678 MirTarget -0.215788921370799 0.0443328290903608 NA NA NA hsa-miR-107 ABCA6 -0.289737369453023 0.769655185893943 -0.0113025832353411 0.980222515728787 miRanda -0.386206815721491 0.00470843933313109 NA NA NA hsa-miR-15b-5p ABCB5 0.251826642099145 0.790709218602499 1.02537526594708 0.0820602917286101 MirTarget -0.37278979036989 0.0246150474959498 NA NA NA hsa-miR-107 ABHD12B -0.289737369453023 0.769655185893943 0.0926809214178475 0.832547753058811 miRanda -0.367715509249656 0.0014767166347221 NA NA NA hsa-miR-107 ABHD13 -0.289737369453023 0.769655185893943 0.0880398765941282 0.821843894057664 MirTarget;miRanda -0.10505739292321 0.00367860711833696 NA NA NA hsa-miR-107 ABR -0.289737369453023 0.769655185893943 -0.461179591458234 0.367742955301533 miRanda -0.130862418463922 0.0407371616025406 NA NA NA hsa-miR-222-3p ACACA -0.233673471709747 0.726651775432807 -0.229138868482066 0.667346204896078 miRNAWalker2_validate -0.101095961777545 0.00385851473044844 NA NA NA hsa-miR-107 ACO1 -0.289737369453023 0.769655185893943 0.0109921839687521 0.981996243736166 miRanda -0.146345422966013 0.00127334582369869 NA NA NA hsa-miR-107 ACTG2 -0.289737369453023 0.769655185893943 0.61629905264253 0.281774547239621 miRanda -0.328518685350516 0.0255337304121472 NA NA NA hsa-miR-140-3p ACVR2B -0.105651799466207 0.9077781740714 -0.143270074789807 0.740318276454807 miRNAWalker2_validate;PITA;miRNATAP -0.11952888908484 0.0243752084439025 NA NA NA hsa-miR-15b-5p ACVR2B 0.251826642099145 0.790709218602499 -0.143270074789807 0.740318276454807 miRNATAP -0.280375845269428 1.92811542397483e-06 NA NA NA hsa-miR-221-3p ADAM11 -0.261179092929062 0.744019631321393 -0.511569387683909 0.144437249240675 miRNATAP -0.301622531013277 0.000224395710627432 NA NA NA hsa-miR-222-3p ADAM11 -0.233673471709747 0.726651775432807 -0.511569387683909 0.144437249240675 miRNATAP -0.258750021160582 0.0014686298308555 NA NA NA hsa-miR-221-3p ADAM22 -0.261179092929062 0.744019631321393 0.358744675636719 0.387333598458432 MirTarget;miRNATAP -0.360321816594511 0.000151059946974442 NA NA NA hsa-miR-222-3p ADAM22 -0.233673471709747 0.726651775432807 0.358744675636719 0.387333598458432 MirTarget;miRNATAP -0.335129307180315 0.000389898745507334 NA NA NA hsa-miR-197-3p ADAMTS1 0.0240027695773914 0.981971058073739 -0.258004050803228 0.696089741103685 miRNATAP -0.20422345199331 0.0453445142416977 NA NA NA hsa-miR-27a-3p ADAMTS10 0.309634509674364 0.703724209648479 -0.0142132801593049 0.969873234209021 MirTarget;miRNATAP -0.207026857203541 0.0131788380330715 NA NA NA hsa-miR-15b-5p ADAMTS18 0.251826642099145 0.790709218602499 -0.280751107758864 0.549022782469007 miRNATAP -0.49754983571533 0.000497768228941499 NA NA NA hsa-miR-107 ADAMTS19 -0.289737369453023 0.769655185893943 -0.26799726419209 0.711866073448671 miRanda -0.432900856401642 0.0193248194280713 NA NA NA hsa-miR-148a-3p ADAMTS19 -0.324144803192141 0.746264759480212 -0.26799726419209 0.711866073448671 MirTarget -0.301249873354563 0.0405932480369829 NA NA NA hsa-miR-15b-5p ADAMTS5 0.251826642099145 0.790709218602499 -0.00185057499031682 0.996540799356434 miRNATAP -0.324491334640395 0.00415047431381499 NA NA NA hsa-miR-221-3p ADAMTS6 -0.261179092929062 0.744019631321393 0.125580301241154 0.724846911503146 MirTarget -0.179907047847241 0.0298499172641118 NA NA NA hsa-miR-222-3p ADAMTS6 -0.233673471709747 0.726651775432807 0.125580301241154 0.724846911503146 MirTarget -0.203949208172817 0.0129570775522397 NA NA NA hsa-miR-107 ADAMTSL3 -0.289737369453023 0.769655185893943 -0.0396425098915616 0.933421479798619 MirTarget;PITA;miRanda;miRNATAP -0.287574268081256 0.0338602296743775 NA NA NA hsa-miR-150-5p ADCY1 -0.00683324482969283 0.994067057151257 -0.136166970563614 0.729350109785873 mirMAP -0.199137825435333 0.000171034709537618 NA NA NA hsa-miR-128-3p ADCY2 -0.0364518492233463 0.95841670253784 -0.1605716568309 0.819369351249095 MirTarget -0.767567002290905 0.000342417105382799 NA NA NA hsa-miR-148a-3p ADCY2 -0.324144803192141 0.746264759480212 -0.1605716568309 0.819369351249095 MirTarget;miRNATAP -0.466733878701922 0.00441717237048026 NA NA NA hsa-miR-107 ADCYAP1 -0.289737369453023 0.769655185893943 0.668825765815771 0.312073170348457 MirTarget;PITA;miRanda;miRNATAP -0.63494964361952 0.000477710411393023 NA NA NA hsa-miR-150-5p ADCYAP1R1 -0.00683324482969283 0.994067057151257 0.794247395527034 0.273015470971313 mirMAP -0.495472569014078 9.79486161128313e-07 NA NA NA hsa-miR-150-5p ADRA2B -0.00683324482969283 0.994067057151257 -0.510539705893778 0.21803612446203 mirMAP -0.195728484906417 0.000727460739526366 NA NA NA hsa-miR-22-3p AGBL5 0.0468440219945929 0.967778504781139 0.0905910037581368 0.874374000695286 MirTarget;miRNATAP -0.161406284451993 5.00904836697278e-06 NA NA NA hsa-miR-15b-5p AGPAT4 0.251826642099145 0.790709218602499 -0.101365308772345 0.783505840899964 mirMAP -0.309400139597459 1.90252662574046e-05 NA NA NA hsa-miR-15b-5p AHCYL2 0.251826642099145 0.790709218602499 -0.00481746947345574 0.991118801570005 miRNATAP -0.109356481116602 0.0128982805607684 NA NA NA hsa-miR-15b-5p AHRR 0.251826642099145 0.790709218602499 -0.449564965936622 0.157514489593808 mirMAP -0.233680084689247 0.010856246236865 NA NA NA hsa-miR-128-3p AKR7A2 -0.0364518492233463 0.95841670253784 0.393407728380821 0.446115703498878 MirTarget -0.117961139854515 0.00474783426997669 NA NA NA hsa-miR-107 AKT3 -0.289737369453023 0.769655185893943 0.0947859458741349 0.829894131767605 PITA;miRanda -0.286283898354911 0.00414419911481135 NA NA NA hsa-miR-107 ALDH1A2 -0.289737369453023 0.769655185893943 1.22455153716573 0.0697715528600013 miRanda -0.401183192242596 0.0379395447268054 NA NA NA hsa-miR-27a-3p ALDH9A1 0.309634509674364 0.703724209648479 0.0462176196486039 0.93051000062085 miRNAWalker2_validate -0.14460389560942 5.3425064059128e-06 NA NA NA hsa-miR-150-5p ALS2CR12 -0.00683324482969283 0.994067057151257 -0.55593093845038 0.290161211682283 MirTarget -0.241244088766436 0.00019010954289654 NA NA NA hsa-miR-107 AMFR -0.289737369453023 0.769655185893943 0.0343461951799338 0.953649502838488 miRanda -0.180318684122681 6.61920468473298e-06 NA NA NA hsa-miR-150-5p AMIGO1 -0.00683324482969283 0.994067057151257 -0.262423194855389 0.361851216964202 mirMAP -0.102731209444192 0.000229523913885984 NA NA NA hsa-miR-222-3p AMMECR1 -0.233673471709747 0.726651775432807 -0.136739834032924 0.774279484223647 miRNATAP -0.112348571614298 0.0102118940525544 NA NA NA hsa-miR-381-3p AMN1 0.269633663970002 0.562625029053898 0.129493191446234 0.762902185645286 MirTarget -0.149656746195051 0.000724117481164779 NA NA NA hsa-miR-27a-3p AMOTL1 0.309634509674364 0.703724209648479 0.662499087105108 0.214709397666152 mirMAP -0.151114765080162 0.021997223760726 NA NA NA hsa-miR-27a-3p ANK1 0.309634509674364 0.703724209648479 -0.597982888297342 0.210086729938373 miRNATAP -0.372598432904112 0.00264730041255033 NA NA NA hsa-miR-15b-5p ANK2 0.251826642099145 0.790709218602499 0.0796094147748652 0.862500758786231 MirTarget;miRNATAP -0.347658568230006 0.0036170249937798 NA NA NA hsa-miR-107 ANKMY2 -0.289737369453023 0.769655185893943 0.0689117540515474 0.853295413134394 miRanda -0.110727440117534 0.026750747511044 NA NA NA hsa-miR-15b-5p ANKRD13B 0.251826642099145 0.790709218602499 0.023221446731279 0.948850145859197 miRNATAP -0.253675622711755 0.0011873292938647 NA NA NA hsa-miR-15b-5p ANKRD29 0.251826642099145 0.790709218602499 0.37785994845105 0.256732154845484 MirTarget -0.264268896768679 0.00946800274707432 NA NA NA hsa-miR-15b-5p ANKRD46 0.251826642099145 0.790709218602499 0.120231891569142 0.775398222006662 MirTarget -0.171922877380229 0.000426997248521459 NA NA NA hsa-miR-221-3p ANKRD52 -0.261179092929062 0.744019631321393 -0.188527554564534 0.747302985770909 miRNATAP -0.123744650841191 0.000530022018567325 NA NA NA hsa-miR-222-3p ANKRD52 -0.233673471709747 0.726651775432807 -0.188527554564534 0.747302985770909 miRNATAP -0.149484195169689 2.22827511181798e-05 NA NA NA hsa-miR-15b-5p ANKS1A 0.251826642099145 0.790709218602499 -0.288207593143918 0.61184174008611 MirTarget -0.161960029303134 0.000689062916627648 NA NA NA hsa-miR-214-3p ANKS1B 0.0312810611346688 0.952640488671912 0.306308430699038 0.399381539749385 miRNATAP -0.188267561055325 0.000812367289406013 NA NA NA hsa-miR-148a-3p ANKS6 -0.324144803192141 0.746264759480212 -0.0343270562125761 0.944656633896678 mirMAP -0.101287197313922 0.00502691254522411 NA NA NA hsa-miR-107 ANTXR1 -0.289737369453023 0.769655185893943 0.539759749710266 0.427966400884912 miRanda -0.197042409250225 0.0116039121102554 NA NA NA hsa-miR-660-5p ANTXR1 -0.561687438133488 0.138270972367544 0.539759749710266 0.427966400884912 mirMAP -0.1268376162704 0.00946355128761485 NA NA NA hsa-miR-107 AP1S2 -0.289737369453023 0.769655185893943 0.107772475792509 0.783519490150423 PITA;miRanda -0.107702642063547 0.0394079351219164 NA NA NA hsa-miR-107 AP2A1 -0.289737369453023 0.769655185893943 -0.0460627757933176 0.941573420555596 miRanda -0.147372943762635 2.03755696060255e-05 NA NA NA hsa-miR-15b-5p AP2A1 0.251826642099145 0.790709218602499 -0.0460627757933176 0.941573420555596 miRNATAP -0.10181870677062 0.00480543720392568 NA NA NA hsa-miR-107 APBA1 -0.289737369453023 0.769655185893943 -0.0110002112322585 0.975583597686264 miRNATAP -0.220468742792577 0.00205243103075801 NA NA NA hsa-miR-15b-5p APRT 0.251826642099145 0.790709218602499 0.409675703844303 0.479755897451844 miRNAWalker2_validate -0.124235287273668 0.0232959313644253 NA NA NA hsa-miR-15b-5p AQP11 0.251826642099145 0.790709218602499 -0.822604445158749 0.00192335564021062 MirTarget -0.408472204211149 5.51902247775802e-09 NA NA NA hsa-miR-27a-3p AQP11 0.309634509674364 0.703724209648479 -0.822604445158749 0.00192335564021062 MirTarget;miRNATAP -0.228548560767848 0.00014132829765964 NA NA NA hsa-miR-22-3p ARC 0.0468440219945929 0.967778504781139 -0.248282159806999 0.596661730587338 mirMAP -0.312350115041477 0.00365307407055968 NA NA NA hsa-miR-128-3p ARHGAP23 -0.0364518492233463 0.95841670253784 -0.185901102266786 0.770178384296621 MirTarget -0.207942764454724 0.00445832724214741 NA NA NA hsa-miR-107 ARHGAP24 -0.289737369453023 0.769655185893943 0.109467456393916 0.728338095797316 miRanda -0.177711069320301 0.0158684933284331 NA NA NA hsa-miR-98-5p ARHGAP28 -0.0484028619275874 0.910781316485549 0.322828502676271 0.377357982273618 miRNAWalker2_validate;MirTarget -0.217643323013662 0.000260775843566463 NA NA NA hsa-miR-148a-3p ARHGEF17 -0.324144803192141 0.746264759480212 -0.299486231342092 0.637742415254754 miRNATAP -0.107203361253192 0.00677035313093866 NA NA NA hsa-miR-15b-5p ARL2 0.251826642099145 0.790709218602499 0.0776760229588875 0.89101937265624 MirTarget;miRNATAP -0.162873273657352 0.00136764225009551 NA NA NA hsa-miR-140-3p ARL6IP1 -0.105651799466207 0.9077781740714 -0.02412259371002 0.973302760751521 miRNATAP -0.179966253343358 5.66164190545632e-06 NA NA NA hsa-miR-139-5p ARMC2 -0.0625698939687087 0.914810329989088 -0.0307329009745307 0.898107518989922 MirTarget -0.105749726220102 0.0357340369497645 NA NA NA hsa-miR-15b-5p ARMC5 0.251826642099145 0.790709218602499 -0.112236617482046 0.767255579718848 mirMAP;miRNATAP -0.164293881874115 3.58825751446158e-05 NA NA NA hsa-miR-15b-5p ARVCF 0.251826642099145 0.790709218602499 -0.627255947319014 0.129396076778317 mirMAP -0.169677905939172 0.00576217525217427 NA NA NA hsa-miR-27a-3p ARX 0.309634509674364 0.703724209648479 -1.62932830189481 0.0701159942616033 miRNATAP -0.54787440440895 0.0190998030209078 NA NA NA hsa-miR-214-3p ASF1B 0.0312810611346688 0.952640488671912 0.0933143302197523 0.861811994940446 miRNAWalker2_validate -0.108376485311659 0.00626747076450623 NA NA NA hsa-miR-15b-5p ASTN1 0.251826642099145 0.790709218602499 0.610239474789576 0.311296702343616 MirTarget -0.363865904382073 0.0488073570409128 NA NA NA hsa-miR-221-3p ASXL3 -0.261179092929062 0.744019631321393 0.0531685877968833 0.926389212317434 miRNAWalker2_validate -0.292075898899439 0.0237738593425286 NA NA NA hsa-miR-15b-5p ATF7IP2 0.251826642099145 0.790709218602499 -0.188735079213755 0.589298029645364 miRNATAP -0.162303866181351 0.0144190195027338 NA NA NA hsa-miR-27a-3p ATOH7 0.309634509674364 0.703724209648479 -0.43820152686997 0.326498683837155 miRNATAP -0.394679098066391 8.81927357290049e-05 NA NA NA hsa-miR-107 ATP11B -0.289737369453023 0.769655185893943 0.0421567198214783 0.933451954251035 miRanda -0.176354525708427 7.8731601019155e-05 NA NA NA hsa-miR-150-5p ATP1A2 -0.00683324482969283 0.994067057151257 0.824377739915931 0.164520481874588 mirMAP -0.169746478174759 0.0455143549075697 NA NA NA hsa-miR-222-3p ATP7B -0.233673471709747 0.726651775432807 -0.100401305816089 0.821976592657238 miRNAWalker2_validate -0.22760035216187 0.000121088032025173 NA NA NA hsa-miR-27a-3p ATP7B 0.309634509674364 0.703724209648479 -0.100401305816089 0.821976592657238 miRNAWalker2_validate -0.173049851804704 0.00947000396782939 NA NA NA hsa-miR-15b-5p ATXN7L1 0.251826642099145 0.790709218602499 -0.0651660876457711 0.859842343416461 miRNATAP -0.140856531955061 0.0018771247650649 NA NA NA hsa-miR-15b-5p ATXN7L2 0.251826642099145 0.790709218602499 -0.305035140611444 0.359886811792949 MirTarget;miRNATAP -0.141190359130148 0.00644051685686942 NA NA NA hsa-miR-15b-5p ATXN7L3 0.251826642099145 0.790709218602499 -0.174452707723041 0.747958984952326 MirTarget;miRNATAP -0.122685507273605 0.000843787900588488 NA NA NA hsa-miR-15b-5p ATXN7L3B 0.251826642099145 0.790709218602499 0.0666914921274744 0.918757807569171 MirTarget -0.115873285630816 0.00587089894335372 NA NA NA hsa-miR-363-3p B3GALT2 -0.186046567396088 0.728622856049059 0.0117321430184167 0.972005203378632 MirTarget -0.130765233716131 0.00446869125118555 NA NA NA hsa-miR-150-5p B4GALNT3 -0.00683324482969283 0.994067057151257 -0.475608423311214 0.312015782371036 mirMAP -0.237447049779657 6.77017124998706e-06 NA NA NA hsa-miR-27a-3p B4GALT3 0.309634509674364 0.703724209648479 0.0135684890033572 0.9792109656104 MirTarget;miRNATAP -0.157445564508993 1.62636254387801e-07 26987623 B4GALT3 up regulation by miR 27a contributes to the oncogenic activity in human cervical cancer cells; To explore the mechanism of dysregulation B4GALT3 was predicted to be a target of miR-27a; EGFP and pGL3-promoter reporter assay showed miR-27a binds to B4GALT3 3'UTR region but enhanced its expression; Furthermore shR-B4GALT3 counteracted the promotion of malignancies induced by miR-27a suggesting miR-27a upregulates B4GALT3 to enhance tumorigenic activities; Altogether our findings evidenced that B4GALT3 upregulated by miR-27a contributes to the tumorigenic activities by β1-integrin pathway and might provide potential biomarkers for cervical cancer cervical and endocervical cancer hsa-miR-148a-3p B4GALT5 -0.324144803192141 0.746264759480212 0.145239508552699 0.834143413923099 MirTarget;miRNATAP -0.12964456495679 8.77765207918221e-05 NA NA NA hsa-miR-148a-3p BACH2 -0.324144803192141 0.746264759480212 3.59502479421181e-05 0.999920470056508 MirTarget;miRNATAP -0.239371462369303 0.00257823554424586 NA NA NA hsa-miR-15b-5p BACH2 0.251826642099145 0.790709218602499 3.59502479421181e-05 0.999920470056508 MirTarget;miRNATAP -0.20528032019449 0.0483142505205604 NA NA NA hsa-miR-15b-5p BAMBI 0.251826642099145 0.790709218602499 0.0384048009127782 0.931373708163178 miRNAWalker2_validate -0.293993858550452 0.0208188403495997 NA NA NA hsa-miR-107 BASP1 -0.289737369453023 0.769655185893943 0.173681340396683 0.73895698730428 miRanda -0.252426727456206 0.00947977552048052 NA NA NA hsa-miR-15b-5p BCL2 0.251826642099145 0.790709218602499 0.000634771319967697 0.998709437687408 miRNAWalker2_validate;miRTarBase -0.224084718519069 0.00768379109864967 25594541;26915294;26884837;18449891 MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MiR 15b mediates liver cancer cells proliferation through targeting BCL 2; MiR-15b overexpression downregulated BCL2 mRNA and protein expression obviously P < 0.05; On the contrary miR-15b inhibitor transfection markedly reduced miR-15b expression in liver cancer cells P < 0.05 promoted tumor cell proliferation and increased BCL2 mRNA and protein expression; MiR-15b can inhibit HepG2 cell proliferation and down-regulate BCL2 mRNA and protein expression;miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2 ;poor survival;;drug resistance breast cancer;lung cancer;liver cancer;gastric cancer hsa-miR-22-3p BCL9 0.0468440219945929 0.967778504781139 -0.0473050382855567 0.938907861608285 MirTarget;miRNATAP -0.131996543193398 0.000532954631801289 NA NA NA hsa-miR-98-5p BEGAIN -0.0484028619275874 0.910781316485549 -0.060157589424727 0.861678577307678 MirTarget -0.145859419142528 0.0294111082730724 NA NA NA hsa-miR-15b-5p BEX1 0.251826642099145 0.790709218602499 0.214063751177022 0.773133404300911 miRNAWalker2_validate -0.580594666066984 0.0119165097163551 NA NA NA hsa-miR-139-5p BICD1 -0.0625698939687087 0.914810329989088 -0.0488173476238858 0.917345354453825 miRanda -0.116025793291248 0.034659360171015 NA NA NA hsa-miR-221-3p BMF -0.261179092929062 0.744019631321393 -0.0417890111864159 0.935049602358016 miRNAWalker2_validate;miRTarBase;miRNATAP -0.326089471305255 5.82706766027774e-09 19671867 MicroRNA 221 targets Bmf in hepatocellular carcinoma and correlates with tumor multifocality; This study aims to investigate the role of miR-221 in the modulation of Bmf a proapoptotic BH3-only protein and to characterize miR-221 contribution to hepatocarcinogenesis through modulation of apoptosis; Transfection of miR-221 and anti-miR-221 in HCC-derived cell lines and luciferase reporter assay were used to assess Bmf as a target of miR-221; Modulation of miR-221 and Bmf expression contributed to characterize their role in anoikis; Enforced miR-221 expression caused Bmf down-regulation whereas anti-miR-221 induced its up-regulation; A luciferase reporter assay confirmed Bmf as a target of miR-221; Our results indicate that miR-221 by targeting Bmf inhibits apoptosis tumorigenesis liver cancer hsa-miR-222-3p BMF -0.233673471709747 0.726651775432807 -0.0417890111864159 0.935049602358016 miRNATAP -0.32208573511459 6.87007185946616e-09 NA NA NA hsa-miR-148a-3p BMP3 -0.324144803192141 0.746264759480212 -0.0702305581443115 0.910805216417524 MirTarget -0.341425961145396 0.0216369867287721 NA NA NA hsa-miR-22-3p BMP7 0.0468440219945929 0.967778504781139 0.867122741702786 0.271084009545316 miRNAWalker2_validate;miRTarBase -0.314121211679014 0.0275650894839941 NA NA NA hsa-miR-150-5p BMPR1B -0.00683324482969283 0.994067057151257 -0.166367671083546 0.732050447276592 MirTarget -0.137668739773401 0.00180378042874386 NA NA NA hsa-miR-221-3p BNIP3 -0.261179092929062 0.744019631321393 0.184483188613369 0.747457032560203 miRNAWalker2_validate -0.156488964432951 0.00383875700456786 NA NA NA hsa-miR-127-3p BOLA1 0.231539840651733 0.822108193638849 0.0890982196984855 0.815693620934991 miRanda -0.11630776580803 0.000346751941188002 NA NA NA hsa-miR-15b-5p BRSK2 0.251826642099145 0.790709218602499 -0.33402149332374 0.545031240280552 mirMAP -0.580782384444895 0.000541784376526562 NA NA NA hsa-miR-22-3p BRSK2 0.0468440219945929 0.967778504781139 -0.33402149332374 0.545031240280552 MirTarget;miRNATAP -0.30350337202271 0.0153626247895106 NA NA NA hsa-miR-27a-3p BRSK2 0.309634509674364 0.703724209648479 -0.33402149332374 0.545031240280552 MirTarget;miRNATAP -0.449532625797826 0.00152044602383748 NA NA NA hsa-miR-222-3p BRWD3 -0.233673471709747 0.726651775432807 -0.316779338911354 0.336200761675276 MirTarget;miRNATAP -0.129547303768451 0.00276061488130137 NA NA NA hsa-miR-15b-5p BTBD19 0.251826642099145 0.790709218602499 -0.157014899701704 0.650167542949539 mirMAP -0.465335486050508 6.21492477634591e-06 NA NA NA hsa-miR-221-3p BTBD3 -0.261179092929062 0.744019631321393 -0.101207548777849 0.845723759270091 miRNATAP -0.157705358441579 3.92522448840952e-05 NA NA NA hsa-miR-222-3p BTBD3 -0.233673471709747 0.726651775432807 -0.101207548777849 0.845723759270091 miRNATAP -0.179667431632554 2.09314854307281e-06 NA NA NA hsa-miR-22-3p BTF3 0.0468440219945929 0.967778504781139 0.255177379923879 0.728792707057093 miRNAWalker2_validate -0.220582679250491 9.35024782409572e-10 NA NA NA hsa-miR-15b-5p BTG2 0.251826642099145 0.790709218602499 0.11777119556448 0.853263096478147 MirTarget;miRNATAP -0.153436068415509 0.0255538047967593 NA NA NA hsa-miR-139-5p BTN3A1 -0.0625698939687087 0.914810329989088 -0.19925065861017 0.689327314668632 miRanda -0.126212955972188 0.00553427519089384 NA NA NA hsa-miR-15b-5p BTRC 0.251826642099145 0.790709218602499 0.111575075634414 0.791035769071 MirTarget;miRNATAP -0.13371734400723 0.000379992592739498 NA NA NA hsa-miR-660-5p BVES -0.561687438133488 0.138270972367544 -0.208457800759825 0.599770132069546 miRNATAP -0.199586106792667 0.00606445361033671 NA NA NA hsa-miR-98-5p C10orf105 -0.0484028619275874 0.910781316485549 -0.141772237454016 0.678154287145507 mirMAP -0.167319631049303 0.0121339116467583 NA NA NA hsa-miR-197-3p C11orf45 0.0240027695773914 0.981971058073739 0.147041466764163 0.613035924686667 mirMAP -0.130830146711483 0.0407757555392051 NA NA NA hsa-miR-27a-3p C1orf21 0.309634509674364 0.703724209648479 0.373416405688308 0.41243946084174 mirMAP;miRNATAP -0.182518330223782 0.00753681953427547 NA NA NA hsa-miR-150-5p C3orf18 -0.00683324482969283 0.994067057151257 -0.0251749198579749 0.933128748647289 miRNATAP -0.100786259499794 6.22874843484828e-05 NA NA NA hsa-miR-107 C5 -0.289737369453023 0.769655185893943 -0.00936249600104522 0.977770121078505 miRanda -0.213780949208935 0.0267291537101959 NA NA NA hsa-miR-107 C9orf69 -0.289737369453023 0.769655185893943 -0.0280401207632179 0.956947978226639 PITA;miRNATAP -0.121306687128691 0.00139258303198185 NA NA NA hsa-miR-140-3p CABLES1 -0.105651799466207 0.9077781740714 0.182466475237517 0.733712926143519 MirTarget -0.122643229882943 0.044663472230867 NA NA NA hsa-miR-140-3p CABLES2 -0.105651799466207 0.9077781740714 -0.0658221439623237 0.891536295435266 miRNATAP -0.101003562742072 0.0207490839612909 NA NA NA hsa-miR-27a-3p CABP1 0.309634509674364 0.703724209648479 0.0288510228310721 0.936145069789164 miRNATAP -0.235516219714145 0.00482458413070372 NA NA NA hsa-miR-221-3p CABYR -0.261179092929062 0.744019631321393 -0.156406359135168 0.632342662103814 miRNAWalker2_validate;miRNATAP -0.228438146808519 0.000334771887826035 NA NA NA hsa-miR-222-3p CABYR -0.233673471709747 0.726651775432807 -0.156406359135168 0.632342662103814 miRNAWalker2_validate;miRNATAP -0.242529335465493 0.000120805147433046 NA NA NA hsa-miR-107 CACNA1C -0.289737369453023 0.769655185893943 0.321111375195311 0.382866117161134 miRNATAP -0.215624878432062 0.0278533452324335 NA NA NA hsa-miR-150-5p CACNA1D -0.00683324482969283 0.994067057151257 0.35365209282459 0.342756295107948 MirTarget -0.171355505218766 0.000618118153053849 NA NA NA hsa-miR-363-3p CACNA1I -0.186046567396088 0.728622856049059 -0.245425770031336 0.61966341479086 MirTarget -0.217933814284047 0.00147992983819243 NA NA NA hsa-miR-27a-3p CACNB2 0.309634509674364 0.703724209648479 -0.313953873211633 0.173309172489937 MirTarget;miRNATAP -0.161770357341688 0.00524767661728532 NA NA NA hsa-miR-221-3p CACNB4 -0.261179092929062 0.744019631321393 0.103600845313522 0.73606959296772 miRNATAP -0.217790858019531 0.00156189931718751 NA NA NA hsa-miR-222-3p CACNB4 -0.233673471709747 0.726651775432807 0.103600845313522 0.73606959296772 miRNATAP -0.254937793115698 0.000180667672098207 NA NA NA hsa-miR-148a-3p CADM1 -0.324144803192141 0.746264759480212 0.618481003096384 0.291358497692688 MirTarget -0.133116951241011 0.0207339323681916 NA NA NA hsa-miR-363-3p CADM2 -0.186046567396088 0.728622856049059 0.035505313475066 0.962685806609167 MirTarget;mirMAP -0.324356069777611 0.00124918989005649 NA NA NA hsa-miR-98-5p CADM2 -0.0484028619275874 0.910781316485549 0.035505313475066 0.962685806609167 MirTarget -0.461349602810529 0.000853936837650642 NA NA NA hsa-miR-107 CALD1 -0.289737369453023 0.769655185893943 0.408768742626957 0.567136542717145 miRanda -0.167293165235684 0.00863686304413302 NA NA NA hsa-miR-27a-3p CALM3 0.309634509674364 0.703724209648479 -0.0020415540902885 0.997795063983713 miRNATAP -0.129188665690644 0.00022526084983384 NA NA NA hsa-miR-140-3p CAMK2B -0.105651799466207 0.9077781740714 -0.108926760524682 0.815953660706715 mirMAP -0.365134491006533 0.00393270944275709 NA NA NA hsa-miR-150-5p CAMK2B -0.00683324482969283 0.994067057151257 -0.108926760524682 0.815953660706715 mirMAP -0.263341203941981 5.22286410017336e-05 NA NA NA hsa-miR-107 CAMKK1 -0.289737369453023 0.769655185893943 -0.608702847569557 0.0593914838724728 miRNATAP -0.155262940760325 0.0249121919672313 NA NA NA hsa-miR-15b-5p CAMKV 0.251826642099145 0.790709218602499 -0.0367466414413129 0.958227125835942 miRNATAP -0.496363040130566 0.00563819167249271 NA NA NA hsa-miR-127-3p CAMTA1 0.231539840651733 0.822108193638849 0.0427197878498786 0.932067943062932 miRanda -0.117492413367757 2.06423040291402e-05 NA NA NA hsa-miR-221-3p CAMTA1 -0.261179092929062 0.744019631321393 0.0427197878498786 0.932067943062932 MirTarget -0.11189113860202 0.00196786253383554 NA NA NA hsa-miR-107 CAPN2 -0.289737369453023 0.769655185893943 -0.21598812946354 0.75884804498723 miRanda -0.158602042947662 0.00224118424175136 NA NA NA hsa-miR-150-5p CAPN6 -0.00683324482969283 0.994067057151257 0.265780001866761 0.687745300777434 miRNATAP -0.189788596390303 0.0441523735184614 NA NA NA hsa-miR-15b-5p CAPN6 0.251826642099145 0.790709218602499 0.265780001866761 0.687745300777434 miRNATAP -0.4280200453095 0.0368793195099512 NA NA NA hsa-miR-222-3p CAPRIN2 -0.233673471709747 0.726651775432807 -0.447611109435524 0.227579711739209 MirTarget;miRNATAP -0.110521524822757 0.00162358519524578 NA NA NA hsa-miR-15b-5p CARD10 0.251826642099145 0.790709218602499 -0.353385388360056 0.40430230072346 MirTarget;miRNATAP -0.197265298386745 0.0108495362393243 NA NA NA hsa-miR-222-3p CASC3 -0.233673471709747 0.726651775432807 -0.0333995747581204 0.956420042884236 miRNAWalker2_validate -0.146016992091305 1.7881576188967e-07 NA NA NA hsa-miR-107 CASK -0.289737369453023 0.769655185893943 -0.0488754403478229 0.918992944886548 MirTarget;miRanda;miRNATAP -0.102130084761666 0.0174119057195597 NA NA NA hsa-miR-15b-5p CASKIN1 0.251826642099145 0.790709218602499 -0.383094721578343 0.254839292624992 miRNATAP -0.197986474638942 0.0301230147609322 NA NA NA hsa-miR-15b-5p CASR 0.251826642099145 0.790709218602499 -1.23471388291518 0.0944852866809481 miRNATAP -0.695744256640797 0.00146389614197196 NA NA NA hsa-miR-222-3p CBX2 -0.233673471709747 0.726651775432807 -0.792846679860935 0.0825022507964724 miRNAWalker2_validate -0.396603786133147 1.4387236040738e-07 NA NA NA hsa-miR-221-3p CCDC148 -0.261179092929062 0.744019631321393 0.148807976567331 0.565564208245877 MirTarget -0.120884182571702 0.0419053331625243 NA NA NA hsa-miR-222-3p CCDC148 -0.233673471709747 0.726651775432807 0.148807976567331 0.565564208245877 MirTarget -0.161909544669368 0.00587538869108063 NA NA NA hsa-miR-107 CCDC68 -0.289737369453023 0.769655185893943 -0.49897610481222 0.101979740893168 miRanda -0.18545748859201 0.037778870981662 NA NA NA hsa-miR-128-3p CCL17 -0.0364518492233463 0.95841670253784 -0.150904145319998 0.805686797706974 miRNAWalker2_validate -0.409152129654245 0.0164471118743051 NA NA NA hsa-miR-150-5p CCND1 -0.00683324482969283 0.994067057151257 -0.0380322966451638 0.958702612238351 mirMAP -0.151404606197238 0.00428892796990735 NA NA NA hsa-miR-15b-5p CCND1 0.251826642099145 0.790709218602499 -0.0380322966451638 0.958702612238351 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.486632084367106 2.07935568901809e-05 NA NA NA hsa-miR-15b-5p CCND2 0.251826642099145 0.790709218602499 0.203692656022289 0.732335574960748 miRNATAP -0.501131199417313 4.20957512669768e-05 NA NA NA hsa-miR-660-5p CCND2 -0.561687438133488 0.138270972367544 0.203692656022289 0.732335574960748 mirMAP -0.214526271095927 0.0040314174331345 NA NA NA hsa-miR-15b-5p CCND3 0.251826642099145 0.790709218602499 -0.0411641939215723 0.945055768590678 miRNATAP -0.125173467700277 0.0149522195931355 NA NA NA hsa-miR-127-3p CCNDBP1 0.231539840651733 0.822108193638849 0.414158576379684 0.388302045709077 miRanda -0.109599649725143 0.000132718308916266 NA NA NA hsa-miR-27a-3p CCNG1 0.309634509674364 0.703724209648479 0.0558850639910746 0.9317684777928 MirTarget;miRNATAP -0.151328784382279 0.00283350828041358 NA NA NA hsa-miR-15b-5p CCNT1 0.251826642099145 0.790709218602499 -0.127323406729269 0.676053684573103 miRNATAP -0.123240551539809 0.00976732461284083 NA NA NA hsa-miR-27a-3p CCNT1 0.309634509674364 0.703724209648479 -0.127323406729269 0.676053684573103 miRNATAP -0.107195234700436 0.00765283061547858 NA NA NA hsa-miR-15b-5p CCNT2 0.251826642099145 0.790709218602499 -0.209287474969924 0.64354693040583 MirTarget;miRNATAP -0.104518737536738 0.0046287568304185 NA NA NA hsa-miR-27a-3p CCNT2 0.309634509674364 0.703724209648479 -0.209287474969924 0.64354693040583 MirTarget -0.102038446102214 0.00101180762271689 NA NA NA hsa-miR-139-5p CCT2 -0.0625698939687087 0.914810329989088 0.107309693664384 0.866651833814768 miRanda -0.115198312909679 0.000717763592591641 NA NA NA hsa-miR-221-3p CCT3 -0.261179092929062 0.744019631321393 0.0230856546375673 0.974752842298538 miRNAWalker2_validate -0.122697837462196 1.49008938421669e-06 NA NA NA hsa-miR-214-3p CD164L2 0.0312810611346688 0.952640488671912 0.00269628787011822 0.994756155742427 mirMAP -0.209626490678752 0.00130469065092215 NA NA NA hsa-miR-128-3p CD276 -0.0364518492233463 0.95841670253784 -0.0189334226707434 0.975601417820928 MirTarget -0.100870829193401 0.0167544092202807 NA NA NA hsa-miR-107 CD302 -0.289737369453023 0.769655185893943 0.185639271932675 0.669001620682745 miRanda -0.132885645162752 0.0178692863053616 NA NA NA hsa-miR-214-3p CD320 0.0312810611346688 0.952640488671912 0.132640877137274 0.801588667786061 MirTarget -0.11224350035696 0.000339230222394794 NA NA NA hsa-miR-107 CD79A -0.289737369453023 0.769655185893943 -0.55822696584596 0.375861773647173 miRanda -0.380469493622741 0.0443544086725178 NA NA NA hsa-miR-107 CDC42EP2 -0.289737369453023 0.769655185893943 0.0286474952424243 0.936744251213271 miRanda;miRNATAP -0.125844451668426 0.00960658341365622 NA NA NA hsa-miR-27a-3p CDC42EP3 0.309634509674364 0.703724209648479 0.353408029260419 0.464310834434881 MirTarget -0.114555611909649 0.00845856569870079 NA NA NA hsa-miR-140-3p CDCA7 -0.105651799466207 0.9077781740714 -0.779595264707178 0.0737420434441484 MirTarget -0.173371277836886 0.0368117209825487 NA NA NA hsa-miR-22-3p CDCA7L 0.0468440219945929 0.967778504781139 0.0900202816109656 0.865363255653899 MirTarget -0.18479337381065 0.000143282192721079 NA NA NA hsa-miR-139-5p CDH1 -0.0625698939687087 0.914810329989088 -0.0891790633490537 0.902378985630649 PITA;miRanda -0.113583761492961 0.0343615320777839 NA NA NA hsa-miR-107 CDH13 -0.289737369453023 0.769655185893943 0.136596825579346 0.760054298694383 miRanda -0.23910261041345 0.0412149888066454 NA NA NA hsa-miR-660-5p CDH13 -0.561687438133488 0.138270972367544 0.136596825579346 0.760054298694383 MirTarget -0.209306209159872 0.00419561789331509 NA NA NA hsa-miR-27a-3p CDH24 0.309634509674364 0.703724209648479 -0.543426139371903 0.182615790878281 miRNATAP -0.148463352885657 0.0151656545211692 NA NA NA hsa-miR-150-5p CDHR3 -0.00683324482969283 0.994067057151257 -0.0921588370859039 0.841504952476685 mirMAP -0.352665927261681 3.58451274406882e-08 NA NA NA hsa-miR-197-3p CDK10 0.0240027695773914 0.981971058073739 -0.219498333195412 0.631520180324291 miRNAWalker2_validate -0.130678114442272 0.00794441202509658 NA NA NA hsa-miR-148a-3p CDK19 -0.324144803192141 0.746264759480212 0.0698767518944257 0.877595904542025 miRNAWalker2_validate;MirTarget;miRNATAP -0.134779593596043 0.000185528876684986 NA NA NA hsa-miR-221-3p CDK19 -0.261179092929062 0.744019631321393 0.0698767518944257 0.877595904542025 MirTarget;miRNATAP -0.103303439331592 0.00397372297463864 NA NA NA hsa-miR-222-3p CDK19 -0.233673471709747 0.726651775432807 0.0698767518944257 0.877595904542025 MirTarget;miRNATAP -0.117437418104243 0.000940500344911353 NA NA NA hsa-miR-148a-3p CDK5R1 -0.324144803192141 0.746264759480212 0.00205021992534071 0.993457617313561 MirTarget;miRNATAP -0.133044642732201 0.0109137407574109 NA NA NA hsa-miR-15b-5p CDK5R1 0.251826642099145 0.790709218602499 0.00205021992534071 0.993457617313561 MirTarget;miRNATAP -0.169557801104741 0.0128193277939986 NA NA NA hsa-miR-27a-3p CDK5R1 0.309634509674364 0.703724209648479 0.00205021992534071 0.993457617313561 miRNATAP -0.183668394941203 0.00133127987659913 NA NA NA hsa-miR-660-5p CDK6 -0.561687438133488 0.138270972367544 0.414885735799475 0.451923918792095 mirMAP -0.128303639203854 0.0415531123026267 NA NA NA hsa-miR-221-3p CDKN1B -0.261179092929062 0.744019631321393 -0.0298593007991652 0.955867819488336 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.186502167388942 3.34710434896951e-06 20461750;23637992;19953484;23939688;19126397;20146005;23967190;17569667;22992757;17721077 MiR 221 and MiR 222 alterations in sporadic ovarian carcinoma: Relationship to CDKN1B CDKNIC and overall survival; miR-221 and miR-222 negatively regulate expression of CDKN1B p27 and CDKN1C p57 two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas; In contrast CDKN1B expression was not associated with miR-221 or miR-222 expression;miR-221 knockdown not only blocked cell cycle progression induced cell apoptosis and inhibited cell proliferation in-vitro but it also inhibited in-vivo tumor growth by targeting p27kip1;Based on bioinformatic analysis we found that the seed sequences of miR-221 and miR-222 coincide with each other and p27kip1 is a target for miRNA-221/222;A Slug/miR-221 network has been suggested linking miR-221 activity with the downregulation of a Slug repressor leading to Slug/miR-221 upregulation and p27Kip1 downregulation; Interference with this process can be achieved using antisense miRNA antagomiR molecules targeting miR-221 inducing the downregulation of Slug and the upregulation of p27Kip1;Moreover a series of functional assays demonstrated that mir-221 could directly inhibit cKit p27Kip1 and possibly other pivotal proteins in melanoma;Matched HCC and adjacent non-cancerous samples were assayed for the expression of miR-221 and three G1/S transition inhibitors: p27Kip1 p21WAF1/Cip1and TGF-β1 by in situ hybridization and immunohistochemistry respectively; Real time qRT-PCR was used to investigate miR-221 and p27Kip1 transcripts in different clinical stages; In result miR-221 and TGF-β1 are frequently up-regulated in HCC while p27Kip1 and p21WAF1/Cip1 proteins are frequently down-regulated; In conclusion miR-221 is important in tumorigenesis of HCC possibly by specifically down-regulating p27Kip1 a cell-cycle inhibitor;Additionally the PDGF-dependent increase in cell proliferation appears to be mediated by inhibition of a specific target of miR-221 and down-regulation of p27Kip1;miR 221 and miR 222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1; In all cell lines tested we show an inverse relationship between the expression of miR-221 and miR-222 and the cell cycle inhibitor p27Kip1; Consistently miR-221 and miR-222 knock-down through antisense LNA oligonucleotides increases p27Kip1 in PC3 cells and strongly reduces their clonogenicity in vitro;Peptide nucleic acids targeting miR 221 modulate p27Kip1 expression in breast cancer MDA MB 231 cells; Targeting miR-221 by PNA resulted in i lowering of the hybridization levels of miR-221 measured by RT-qPCR ii upregulation of p27Kip1 gene expression measured by RT-qPCR and western blot analysis;Antagonism of either microRNA 221 or 222 in glioblastoma cells also caused an increase in p27Kip1 levels and enhanced expression of the luciferase reporter gene fused to the p27Kip1 3'UTR poor survival;progression;;;;staging;tumorigenesis;;;; ovarian cancer;breast cancer;glioblastoma;breast cancer;melanoma;liver cancer;pancreatic cancer;prostate cancer;breast cancer;glioblastoma hsa-miR-222-3p CDKN1B -0.233673471709747 0.726651775432807 -0.0298593007991652 0.955867819488336 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.171905428967177 1.65425282255054e-05 24137356;20461750;19953484;26912358;24895988;17569667;27282281 miR 222 is upregulated in epithelial ovarian cancer and promotes cell proliferation by downregulating P27kip1; miR-222 upregulation induced an enhancement of ovarian cancer cell proliferation potential possibly by downregulating its target P27Kip1; A bioinformatic analysis showed that the 3'-UTR of the P27Kip1 mRNA contained a highly-conserved putative miR-222 binding site; Luciferase reporter assays demonstrated that P27Kip1 was a direct target of miR-222; Consistently there was an inverse correlation between the P27Kip1 and miR-222 expression levels in the ovarian cancer cell lines and tissues;MiR 221 and MiR 222 alterations in sporadic ovarian carcinoma: Relationship to CDKN1B CDKNIC and overall survival; miR-221 and miR-222 negatively regulate expression of CDKN1B p27 and CDKN1C p57 two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas; In contrast CDKN1B expression was not associated with miR-221 or miR-222 expression;Based on bioinformatic analysis we found that the seed sequences of miR-221 and miR-222 coincide with each other and p27kip1 is a target for miRNA-221/222;Besides microvesicle marker characterization we evidenced that miR-222 exosomal expression mostly reflected its abundance in the cells of origin correctly paralleled by repression of its target genes such as p27Kip1 and induction of the PI3K/AKT pathway thus confirming its functional implication in cancer;MiR-222 plays an important role in the tumorigenesis of CC possibly by specifically down-regulating p27Kip1 and PTEN;miR 221 and miR 222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1; In all cell lines tested we show an inverse relationship between the expression of miR-221 and miR-222 and the cell cycle inhibitor p27Kip1; Consistently miR-221 and miR-222 knock-down through antisense LNA oligonucleotides increases p27Kip1 in PC3 cells and strongly reduces their clonogenicity in vitro;miR 222 confers the resistance of breast cancer cells to Adriamycin through suppression of p27kip1 expression; Immunofluorescence showed that miR-222 altered the subcellular location of p27kip1 in nucleus; The results showed that downregulation of miR-222 in MCF-7/Adr increased sensitivity to Adr and Adr-induced apoptosis and arrested the cells in G1 phase accompanied by more expressions of p27kip1 especially in nucleus; Taken together the results found that miR-222 induced Adr-resistance at least in part via suppressing p27kip1 expression and altering its subcellular localization and miR-222 inhibitors could reverse Adr-resistance of breast cancer cells ;poor survival;;;tumorigenesis;;drug resistance ovarian cancer;ovarian cancer;glioblastoma;melanoma;cervical and endocervical cancer;prostate cancer;breast cancer hsa-miR-221-3p CDKN1C -0.261179092929062 0.744019631321393 -0.177123859611887 0.729805443825028 miRNAWalker2_validate;miRTarBase;miRNATAP -0.241750058879105 0.000270915923334854 20461750 miR-221 and miR-222 negatively regulate expression of CDKN1B p27 and CDKN1C p57 two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas; Higher miR-222 and miR-221 expression were significantly associated with decreased CDKN1C expression P = 0.009 and 0.01 ovarian cancer hsa-miR-222-3p CDKN1C -0.233673471709747 0.726651775432807 -0.177123859611887 0.729805443825028 miRNAWalker2_validate;miRTarBase;miRNATAP -0.226463753663193 0.00059474086646118 20461750 miR-221 and miR-222 negatively regulate expression of CDKN1B p27 and CDKN1C p57 two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas; Higher miR-222 and miR-221 expression were significantly associated with decreased CDKN1C expression P = 0.009 and 0.01 ovarian cancer hsa-miR-363-3p CDKN1C -0.186046567396088 0.728622856049059 -0.177123859611887 0.729805443825028 MirTarget -0.112218971660057 0.00591285656807397 NA NA NA hsa-miR-150-5p CDON -0.00683324482969283 0.994067057151257 -0.0398457745119654 0.935862654529542 mirMAP -0.105055347703422 0.00323595215120754 NA NA NA hsa-miR-98-5p CELF3 -0.0484028619275874 0.910781316485549 -0.0851278400717028 0.906099412096923 MirTarget -0.412037237432879 0.000194358412726836 NA NA NA hsa-miR-148a-3p CELSR1 -0.324144803192141 0.746264759480212 -0.060546835229248 0.926445543173268 MirTarget -0.134618126071796 0.0113716954036791 NA NA NA hsa-miR-22-3p CENPV 0.0468440219945929 0.967778504781139 0.115471172764651 0.772077028099417 MirTarget -0.262664993383004 0.00232139696998833 NA NA NA hsa-miR-107 CERK -0.289737369453023 0.769655185893943 0.166337448018345 0.753141392543604 mirMAP -0.261659112084135 5.22709778029344e-07 NA NA NA hsa-miR-128-3p CERK -0.0364518492233463 0.95841670253784 0.166337448018345 0.753141392543604 miRNAWalker2_validate -0.137645462234031 0.0127276110343203 NA NA NA hsa-miR-221-3p CHCHD2 -0.261179092929062 0.744019631321393 0.428750321860901 0.531733173269578 miRNAWalker2_validate -0.148478939446517 6.01026228831901e-05 NA NA NA hsa-miR-15b-5p CHD9 0.251826642099145 0.790709218602499 0.0487058628905936 0.917374585656107 miRNATAP -0.15065814609707 0.000360679307515265 NA NA NA hsa-miR-15b-5p CHPF 0.251826642099145 0.790709218602499 0.164798408052501 0.808217354722435 miRNAWalker2_validate -0.210849265667649 0.000255067152609516 NA NA NA hsa-miR-27a-3p CHRM1 0.309634509674364 0.703724209648479 0.193298593054021 0.748997195772092 miRNATAP -0.278063671322202 0.0489487761095914 NA NA NA hsa-miR-150-5p CHRNA7 -0.00683324482969283 0.994067057151257 0.414494134653933 0.417438454118818 mirMAP -0.14735846272629 0.0200052097010977 NA NA NA hsa-miR-15b-5p CIAPIN1 0.251826642099145 0.790709218602499 0.102878812174225 0.83253586475493 miRNATAP -0.119254125449004 0.00108623745682377 NA NA NA hsa-miR-222-3p CKAP2 -0.233673471709747 0.726651775432807 0.197031620415563 0.695920159795526 miRNAWalker2_validate -0.182953550987338 1.01433359018581e-06 NA NA NA hsa-miR-27a-3p CLCN5 0.309634509674364 0.703724209648479 -0.178150103511938 0.678345961474735 miRNATAP -0.168883109115206 0.00560334142697861 NA NA NA hsa-miR-197-3p CLCN6 0.0240027695773914 0.981971058073739 -0.35264349176048 0.440353528550254 mirMAP -0.109165918461056 0.0387435133896412 NA NA NA hsa-miR-15b-5p CLDN19 0.251826642099145 0.790709218602499 0.059322408640073 0.943480447727919 mirMAP -0.630541777380938 0.0124055978839439 NA NA NA hsa-miR-139-5p CLDN4 -0.0625698939687087 0.914810329989088 0.263129602763007 0.741420136203289 miRanda -0.106671697630768 0.0386952875570835 NA NA NA hsa-miR-128-3p CLDN5 -0.0364518492233463 0.95841670253784 0.0540636984812322 0.875249559008165 miRNAWalker2_validate -0.215245521773092 0.00278696158880902 NA NA NA hsa-miR-22-3p CLUAP1 0.0468440219945929 0.967778504781139 -0.00326639480893487 0.99355209405024 mirMAP -0.222504968840014 2.15825624973182e-11 NA NA NA hsa-miR-150-5p CLVS1 -0.00683324482969283 0.994067057151257 0.973271916736074 0.0495428742044872 MirTarget -0.169124795933009 0.016843715135609 NA NA NA hsa-miR-139-5p CMTM8 -0.0625698939687087 0.914810329989088 0.399954730738463 0.32636259314685 miRanda -0.172028248280328 0.000108107106559458 NA NA NA hsa-miR-107 CNN3 -0.289737369453023 0.769655185893943 0.0186698260916538 0.978179984744105 miRanda -0.106417371048869 0.0139226065344594 NA NA NA hsa-miR-139-5p CNPY2 -0.0625698939687087 0.914810329989088 0.335553926100576 0.562197463390072 miRanda -0.102152211281942 0.00133201465549285 NA NA NA hsa-miR-150-5p CNTN2 -0.00683324482969283 0.994067057151257 0.0626820159997719 0.905077114687592 mirMAP -0.153123832299629 0.024925931565515 NA NA NA hsa-miR-107 CNTN3 -0.289737369453023 0.769655185893943 0.636683117253605 0.280139316644036 miRanda -0.357200981542095 0.0395290701701377 NA NA NA hsa-miR-148a-3p CNTN4 -0.324144803192141 0.746264759480212 0.390138807453628 0.485800322944399 miRNATAP -0.342355257988102 0.00963581632901365 NA NA NA hsa-miR-148a-3p CNTNAP2 -0.324144803192141 0.746264759480212 -0.0770204022468783 0.896926055209536 mirMAP -0.300358285603174 0.0324224445626005 NA NA NA hsa-miR-27a-3p CNTNAP2 0.309634509674364 0.703724209648479 -0.0770204022468783 0.896926055209536 miRNATAP -0.370581347204161 0.0161764189903491 NA NA NA hsa-miR-107 COBLL1 -0.289737369453023 0.769655185893943 -0.227876576736832 0.612715681764406 PITA;miRanda;miRNATAP -0.179080606895637 0.0330854067409128 NA NA NA hsa-miR-107 COG6 -0.289737369453023 0.769655185893943 0.155097796557318 0.716915313848921 miRanda -0.131070078589402 0.00139585276934429 NA NA NA hsa-miR-222-3p COIL -0.233673471709747 0.726651775432807 0.260852168383174 0.531392480974126 miRNAWalker2_validate -0.114815318428268 7.14986499583995e-05 NA NA NA hsa-miR-107 COL5A1 -0.289737369453023 0.769655185893943 0.633294658705469 0.430856176814437 miRanda -0.273819910397762 0.0342935424161201 NA NA NA hsa-miR-15b-5p COPS7A 0.251826642099145 0.790709218602499 0.279590984725614 0.62772901217595 miRNATAP -0.143676093916562 0.000377366728411631 NA NA NA hsa-miR-98-5p CPEB1 -0.0484028619275874 0.910781316485549 -0.134882957782761 0.801746545624025 MirTarget -0.238896648915318 0.0225111204935259 NA NA NA hsa-miR-214-3p CPNE4 0.0312810611346688 0.952640488671912 0.255052190280374 0.680227503645346 MirTarget -0.200707908555288 0.0430411886813004 NA NA NA hsa-miR-15b-5p CRIM1 0.251826642099145 0.790709218602499 0.202689844948188 0.72582221191569 MirTarget;miRNATAP -0.135014804859841 0.013425755484803 NA NA NA hsa-miR-221-3p CROT -0.261179092929062 0.744019631321393 0.0401004909523413 0.905546632458772 miRNAWalker2_validate -0.109008910123131 0.00248559621737986 NA NA NA hsa-miR-140-3p CRTC1 -0.105651799466207 0.9077781740714 -0.220881928902426 0.668893180206995 mirMAP -0.101630612966372 0.0314105226839407 NA NA NA hsa-miR-140-3p CTAGE1 -0.105651799466207 0.9077781740714 0.0789414871360687 0.752189732704792 PITA -0.131686300919581 0.0260782605686816 NA NA NA hsa-miR-107 CTDSP1 -0.289737369453023 0.769655185893943 0.155653501582925 0.816578541803765 miRanda -0.131597406889972 0.000155862698880938 NA NA NA hsa-miR-128-3p CTU1 -0.0364518492233463 0.95841670253784 -0.191735767266881 0.631228156476905 MirTarget -0.127408567541442 0.00429731216067145 NA NA NA hsa-miR-22-3p CUL3 0.0468440219945929 0.967778504781139 -0.0233263194948385 0.966605304803416 miRNATAP -0.107787075359271 1.24554633466499e-06 NA NA NA hsa-miR-127-3p CXCL11 0.231539840651733 0.822108193638849 -0.573860008338374 0.31927067815559 miRanda -0.300346891095774 0.00117332838223155 NA NA NA hsa-miR-15b-5p CYB561D1 0.251826642099145 0.790709218602499 -0.424091767920599 0.28999065959536 mirMAP -0.11005254254516 0.0335142289196662 NA NA NA hsa-miR-140-3p CYFIP2 -0.105651799466207 0.9077781740714 -0.0694467175468514 0.893116156849314 MirTarget -0.186154822189148 9.09417358912428e-05 NA NA NA hsa-miR-15b-5p CYP26B1 0.251826642099145 0.790709218602499 0.442793458800653 0.306322577655703 MirTarget;miRNATAP -0.287765859555649 0.0286246327986535 NA NA NA hsa-miR-660-5p CYP26B1 -0.561687438133488 0.138270972367544 0.442793458800653 0.306322577655703 MirTarget -0.294995047535464 0.000186719627854617 NA NA NA hsa-miR-107 CYP2W1 -0.289737369453023 0.769655185893943 -0.728087559293801 0.281526537334884 mirMAP -0.424430296090525 0.0304739071991782 NA NA NA hsa-miR-22-3p DAD1 0.0468440219945929 0.967778504781139 0.0956804418908277 0.884983730532249 MirTarget -0.105123066940079 0.00206122522185403 NA NA NA hsa-miR-222-3p DARS2 -0.233673471709747 0.726651775432807 0.15499405565066 0.751776172832006 miRNAWalker2_validate -0.150086496769081 1.005726074731e-05 NA NA NA hsa-miR-15b-5p DCAF8 0.251826642099145 0.790709218602499 0.0113853870067802 0.98535291263162 MirTarget -0.137010689315996 2.67880238367185e-05 NA NA NA hsa-miR-107 DCLK1 -0.289737369453023 0.769655185893943 0.0609744201620308 0.876725966427871 miRNATAP -0.282866854238758 0.0108019734968418 NA NA NA hsa-miR-139-5p DCP1B -0.0625698939687087 0.914810329989088 0.0103600492824336 0.981908008271292 miRanda -0.125923266495729 0.00029860625830053 NA NA NA hsa-miR-197-3p DDA1 0.0240027695773914 0.981971058073739 0.0316283766535514 0.95479668835842 mirMAP -0.133384955449802 0.00357379249434835 NA NA NA hsa-miR-140-3p DDN -0.105651799466207 0.9077781740714 -0.174843853505509 0.664607630428512 miRNATAP -0.199942188355298 0.0428896791796713 NA NA NA hsa-miR-221-3p DDX52 -0.261179092929062 0.744019631321393 -0.119482824633703 0.77617610112782 mirMAP -0.164298905911958 5.66570850071214e-08 NA NA NA hsa-miR-15b-5p DEF8 0.251826642099145 0.790709218602499 -0.0760343822266334 0.86496372074907 MirTarget -0.193448097344469 7.63737855367691e-07 NA NA NA hsa-miR-221-3p DENR -0.261179092929062 0.744019631321393 -0.0498635076185616 0.927370593731145 miRNAWalker2_validate -0.12289100547636 1.75375810558281e-06 NA NA NA hsa-miR-107 DGCR6 -0.289737369453023 0.769655185893943 -0.0423463663895833 0.903982750653816 miRanda -0.137272693170997 0.0271638500541659 NA NA NA hsa-miR-107 DGCR6L -0.289737369453023 0.769655185893943 -0.0868968423144798 0.853879559550046 miRanda -0.103423309599828 0.0372827716098917 NA NA NA hsa-miR-15b-5p DGKD 0.251826642099145 0.790709218602499 -0.387051615675522 0.325412186035661 mirMAP -0.130972667778844 0.00490883986866329 NA NA NA hsa-miR-107 DHRS12 -0.289737369453023 0.769655185893943 0.215342568728848 0.490845225963659 miRanda -0.127671758154227 0.0145984448443517 NA NA NA hsa-miR-107 DHRS4L2 -0.289737369453023 0.769655185893943 -0.286415076580927 0.429347432484529 miRanda -0.325066583601412 0.000554709611340471 NA NA NA hsa-miR-107 DIP2C -0.289737369453023 0.769655185893943 0.0241787666113469 0.95634520880725 miRanda -0.199355080837331 0.0032009908877288 NA NA NA hsa-miR-221-3p DIRAS3 -0.261179092929062 0.744019631321393 0.138022680891339 0.721265087543955 miRTarBase -0.180865963233304 0.0304218132177821 21071579;23801152;22117988 Further studies on a new mechanism of ARHI downregulation showed a significant inverse relationship between ARHI and miR-221 and 222 which were upregulated in prostate cancer cell lines; Transfection of miR-221 and 222 inhibitors into PC-3 cells caused a significant induction of ARHI expression; A direct interaction of miR-221 or 222 with a target site on the 3'UTR of ARHI was confirmed by a dual luciferase pMIR-REPORT assay; Finally we also found that genistein upregulates ARHI by downregulating miR-221 and 222 in PC-3 cells;Effects of ARHI on breast cancer cell biological behavior regulated by microRNA 221; The downregulation of ARHI was regulated by miR-221 in prostate cancer cell lines; However it has not been reported whether ARHI is regulated by miR-221 in breast cancer; To address whether ARHI is regulated by miR-221 in breast cancer cell lines the results in this study showed that a significant inverse correlation existed between ARHI and miR-221; The inhibition of miR-221 induced a significant upregulation of ARHI in MCF-7 cells; To prove a direct interaction between miR-221 and ARHI mRNA ARHI 3'UTR which includes the potential target site for miR-221 was cloned downstream of the luciferase reporter gene of the pMIR-REPORT vector to generate the pMIR-ARHI-3'UTR vector; The results confirmed a direct interaction of miR-221 with a target site on the 3'UTR of ARHI; This study demonstrated for the first time that the downregulation of ARHI in breast cancer cells could be regulated by miR-221;MicroRNA 221 and 222 have been shown to regulate ARHI expression negatively; Expression of ARHI and microRNA 221 and 222 was measured by real-time reverse transcription-polymerase chain reaction; Whether ARHI and microRNA 221 and 222 could be considered as biomarkers for disease progression in prostate cancer requires further investigation ;;progression prostate cancer;breast cancer;prostate cancer hsa-miR-222-3p DIRAS3 -0.233673471709747 0.726651775432807 0.138022680891339 0.721265087543955 miRTarBase -0.169117626559432 0.0414469096710404 NA NA NA hsa-miR-15b-5p DIXDC1 0.251826642099145 0.790709218602499 0.278415039341975 0.465273271597506 MirTarget -0.163985406740794 0.00259574760551469 NA NA NA hsa-miR-107 DKK1 -0.289737369453023 0.769655185893943 1.00397863183292 0.12946363104636 miRanda -0.662019048090974 0.000357369434070963 NA NA NA hsa-miR-107 DLEU1 -0.289737369453023 0.769655185893943 0.539705499129087 0.045364145911034 miRanda -0.155997483971692 0.00805222397665356 NA NA NA hsa-miR-148a-3p DLG2 -0.324144803192141 0.746264759480212 0.379533315306163 0.304081069740784 MirTarget;miRNATAP -0.195476986276403 0.0242885834699011 NA NA NA hsa-miR-363-3p DLG2 -0.186046567396088 0.728622856049059 0.379533315306163 0.304081069740784 mirMAP -0.111371790934155 0.0339661981784351 NA NA NA hsa-miR-15b-5p DLL1 0.251826642099145 0.790709218602499 0.294788113590102 0.411069437919416 miRNATAP -0.411601755454137 7.51525341204853e-05 NA NA NA hsa-miR-15b-5p DLL4 0.251826642099145 0.790709218602499 -0.368602479212739 0.229619555752877 miRNATAP -0.16890286930773 0.00108435920887059 NA NA NA hsa-miR-107 DMRT2 -0.289737369453023 0.769655185893943 0.0280023824536557 0.967149688369316 miRanda -0.475946716856519 0.00669020102671467 NA NA NA hsa-miR-221-3p DMRT3 -0.261179092929062 0.744019631321393 0.345688354953898 0.606960717050321 MirTarget;miRNATAP -0.36255103394903 0.016438922476834 NA NA NA hsa-miR-222-3p DMRT3 -0.233673471709747 0.726651775432807 0.345688354953898 0.606960717050321 MirTarget;miRNATAP -0.446743754057431 0.00281106543453172 NA NA NA hsa-miR-222-3p DMWD -0.233673471709747 0.726651775432807 -0.121687291649838 0.818294458768291 miRNAWalker2_validate -0.108425005948701 0.000699836210909241 NA NA NA hsa-miR-22-3p DNAJC27 0.0468440219945929 0.967778504781139 -0.106141068710585 0.698089779114498 MirTarget -0.112311411407639 8.39914262174449e-05 NA NA NA hsa-miR-27a-3p DNAJC27 0.309634509674364 0.703724209648479 -0.106141068710585 0.698089779114498 miRNAWalker2_validate;MirTarget;miRNATAP -0.128902899055301 7.08370136190131e-05 NA NA NA hsa-miR-107 DNAJC3 -0.289737369453023 0.769655185893943 0.0529396133010049 0.918145162613122 miRanda -0.135432508512196 0.000507518375490281 NA NA NA hsa-miR-148a-3p DOCK3 -0.324144803192141 0.746264759480212 -0.0166222052716001 0.967344829404864 miRNATAP -0.237555781947253 0.00691554229344623 NA NA NA hsa-miR-140-3p DOK5 -0.105651799466207 0.9077781740714 0.535561087648704 0.38576876834976 miRNATAP -0.258284640582259 0.0210282121919744 NA NA NA hsa-miR-22-3p DPF2 0.0468440219945929 0.967778504781139 0.00237745456848337 0.996715690436653 MirTarget;miRNATAP -0.106303351689186 2.08017784703879e-06 NA NA NA hsa-miR-221-3p DPY19L3 -0.261179092929062 0.744019631321393 -0.15393983102763 0.707347494933269 MirTarget -0.118287187589827 0.00616241381527742 NA NA NA hsa-miR-222-3p DPY19L3 -0.233673471709747 0.726651775432807 -0.15393983102763 0.707347494933269 MirTarget -0.171956882029169 5.25570545609581e-05 NA NA NA hsa-miR-22-3p DPY30 0.0468440219945929 0.967778504781139 0.425705805428714 0.419534780417793 MirTarget -0.131887431399372 0.000107622916648275 NA NA NA hsa-miR-150-5p DPYSL5 -0.00683324482969283 0.994067057151257 -0.557022998839057 0.510670233026649 mirMAP -0.689793705712692 1.90875584455956e-09 NA NA NA hsa-miR-363-3p DSC2 -0.186046567396088 0.728622856049059 0.0536060366685467 0.93234953250075 MirTarget -0.135353689613998 0.00224105568684905 NA NA NA hsa-miR-107 DSE -0.289737369453023 0.769655185893943 -0.0253357981342237 0.953678264673674 miRanda -0.101671171462872 0.0424726688525274 NA NA NA hsa-miR-107 DSEL -0.289737369453023 0.769655185893943 0.388931488895636 0.371345885950686 miRanda;miRNATAP -0.220592333523524 0.0304342909435194 NA NA NA hsa-miR-221-3p DTNA -0.261179092929062 0.744019631321393 0.079919244724207 0.86913793101396 mirMAP -0.463183940957271 4.39416012311961e-06 NA NA NA hsa-miR-107 DUSP7 -0.289737369453023 0.769655185893943 -0.133353800652199 0.776194243532699 miRanda -0.104027687146737 0.0222405184566961 NA NA NA hsa-miR-221-3p DVL2 -0.261179092929062 0.744019631321393 -0.322024825039206 0.507327359550734 miRNAWalker2_validate -0.111635424047559 0.000236771884706682 21487968 MiR 221 expression affects invasion potential of human prostate carcinoma cell lines by targeting DVL2; We also suggest that miR-221 may control the migration of AIPC cells through DVL2 working as a key regulator in advanced CaP staging prostate cancer hsa-miR-15b-5p DYNC1LI2 0.251826642099145 0.790709218602499 -0.00723049691089805 0.989825607150571 MirTarget;miRNATAP -0.112177184617386 0.00209186637554562 NA NA NA hsa-miR-27a-3p DYNC2LI1 0.309634509674364 0.703724209648479 0.330194449344121 0.37937835445585 MirTarget -0.132214047616589 0.00050861931973541 NA NA NA hsa-miR-148a-3p DYRK1B -0.324144803192141 0.746264759480212 0.0459132310244739 0.93769857295231 miRNATAP -0.112400879290334 0.0135409264614976 NA NA NA hsa-miR-15b-5p DYRK1B 0.251826642099145 0.790709218602499 0.0459132310244739 0.93769857295231 MirTarget;miRNATAP -0.137689626174516 0.0203589463044507 NA NA NA hsa-miR-214-3p E2F2 0.0312810611346688 0.952640488671912 -0.30036161792182 0.441465433449537 mirMAP -0.100978493662983 0.0046131021749937 NA NA NA hsa-miR-107 EBF1 -0.289737369453023 0.769655185893943 0.361862231860407 0.312712520874324 MirTarget;miRanda;miRNATAP -0.318824950995242 0.000523012627428682 NA NA NA hsa-miR-15b-5p EDA 0.251826642099145 0.790709218602499 0.335623537399135 0.409639164424153 MirTarget;miRNATAP -0.223990895126348 0.012939550092097 NA NA NA hsa-miR-15b-5p EEF1A1 0.251826642099145 0.790709218602499 0.124313898206736 0.906661592315232 miRNAWalker2_validate -0.207136546751281 8.59455395884229e-05 NA NA NA hsa-miR-197-3p EEF1A1 0.0240027695773914 0.981971058073739 0.124313898206736 0.906661592315232 miRNAWalker2_validate -0.182339823398992 0.000697730486362661 NA NA NA hsa-miR-107 EEF1A1P9 -0.289737369453023 0.769655185893943 0.241325839653457 0.490518791484523 miRanda -0.174690040355524 0.00362869322634614 NA NA NA hsa-miR-128-3p EFEMP2 -0.0364518492233463 0.95841670253784 0.0846998523046159 0.888255700310019 miRNAWalker2_validate -0.137476747480702 0.0399610281219129 NA NA NA hsa-miR-27a-3p EFNA3 0.309634509674364 0.703724209648479 -0.237029528793301 0.535270655381165 miRNATAP -0.19042285448469 0.00164122510965065 NA NA NA hsa-miR-107 EFNB2 -0.289737369453023 0.769655185893943 -0.0415462898228647 0.945513003886044 miRNATAP -0.204808266760602 0.0137120455190931 NA NA NA hsa-miR-148a-3p EFNB2 -0.324144803192141 0.746264759480212 -0.0415462898228647 0.945513003886044 MirTarget;miRNATAP -0.233116661217732 0.000381087741100227 NA NA NA hsa-miR-22-3p EFR3B 0.0468440219945929 0.967778504781139 -0.184292387875329 0.600415783873846 MirTarget -0.242660001442657 0.00133319399287846 NA NA NA hsa-miR-363-3p EGR2 -0.186046567396088 0.728622856049059 0.093736233681752 0.83352480815983 miRNATAP -0.130934732471141 0.00664271614169299 NA NA NA hsa-miR-107 EIF1AX -0.289737369453023 0.769655185893943 0.0463635789388031 0.934275108186525 miRanda -0.15414251796644 0.000889825657424266 NA NA NA hsa-miR-139-5p EIF4A2 -0.0625698939687087 0.914810329989088 0.047295053456212 0.953001307888256 miRanda -0.104169938267191 0.00148368929612165 NA NA NA hsa-miR-15b-5p EIF4B 0.251826642099145 0.790709218602499 0.253724736012796 0.731289892164022 miRNATAP -0.115010477791509 0.00682931396021433 NA NA NA hsa-miR-148a-3p ELFN2 -0.324144803192141 0.746264759480212 0.698277547717831 0.2354082698908 mirMAP -0.462369570862637 0.000774539993007686 NA NA NA hsa-miR-15b-5p ELFN2 0.251826642099145 0.790709218602499 0.698277547717831 0.2354082698908 mirMAP -0.399268266584176 0.0267343403631748 NA NA NA hsa-miR-148a-3p EMX2 -0.324144803192141 0.746264759480212 0.486817038715191 0.511999379831851 miRNATAP -0.529429825732203 1.71387766081361e-06 NA NA NA hsa-miR-107 ENPP1 -0.289737369453023 0.769655185893943 0.738380987953416 0.0958167664835978 miRanda -0.213938006794429 0.0305819189489463 NA NA NA hsa-miR-107 ENTPD3 -0.289737369453023 0.769655185893943 0.615566915436617 0.14444270939096 miRanda -0.354948814562702 0.00232742825830551 NA NA NA hsa-miR-222-3p ENTPD7 -0.233673471709747 0.726651775432807 0.198648540058904 0.60002263716959 MirTarget -0.116921280494716 0.00687411641040975 NA NA NA hsa-miR-222-3p EPB41L2 -0.233673471709747 0.726651775432807 0.399473445231796 0.492457153760958 miRNAWalker2_validate -0.115160288680846 0.0329256117845677 NA NA NA hsa-miR-107 EPHX2 -0.289737369453023 0.769655185893943 -0.0525148582659218 0.900063122006352 miRanda -0.155591107022651 0.023755081091922 NA NA NA hsa-miR-140-3p EPM2AIP1 -0.105651799466207 0.9077781740714 -0.00623458917157027 0.990693948217373 MirTarget -0.110094774910385 0.00704010191535803 NA NA NA hsa-miR-15b-5p ERC2 0.251826642099145 0.790709218602499 0.228089427804528 0.438720877351793 MirTarget;miRNATAP -0.270326749936933 0.00224466181938416 NA NA NA hsa-miR-128-3p ERCC1 -0.0364518492233463 0.95841670253784 0.160493405574076 0.764840131436112 MirTarget -0.121177396109685 0.00968007948093491 NA NA NA hsa-miR-107 ERCC2 -0.289737369453023 0.769655185893943 0.00628532654217473 0.988700388974902 mirMAP -0.19976779325921 1.42195423554797e-05 NA NA NA hsa-miR-222-3p ERCC6L -0.233673471709747 0.726651775432807 -0.217089858470344 0.493189494636312 miRNAWalker2_validate -0.115323184306931 0.0221859407300288 NA NA NA hsa-miR-107 ERG -0.289737369453023 0.769655185893943 0.0326386813167203 0.921192161731388 miRanda -0.169944809788539 0.00838342819654601 NA NA NA hsa-miR-148a-3p ERRFI1 -0.324144803192141 0.746264759480212 0.0831450814570553 0.881700431102294 MirTarget -0.154925211206166 0.0070847249749379 NA NA NA hsa-miR-150-5p ESR2 -0.00683324482969283 0.994067057151257 -1.0594327856377 0.000526723931049 mirMAP -0.171381556299187 6.48811594021669e-05 NA NA NA hsa-miR-15b-5p ESRRG 0.251826642099145 0.790709218602499 0.964494392813018 0.0359709288609969 miRNATAP -0.36194000971874 0.00592193523121315 NA NA NA hsa-miR-15b-5p ETNK1 0.251826642099145 0.790709218602499 0.0784197702546221 0.88043073381994 miRNAWalker2_validate;MirTarget -0.150526463923368 0.00272878162117659 NA NA NA hsa-miR-660-5p ETV1 -0.561687438133488 0.138270972367544 0.551934127902999 0.190947287949481 MirTarget -0.150426154340462 0.0135955138986723 NA NA NA hsa-miR-107 ETV5 -0.289737369453023 0.769655185893943 -0.0732138595467884 0.890560429353369 miRanda -0.181536092106077 0.0468712776880185 NA NA NA hsa-miR-148a-3p ETV5 -0.324144803192141 0.746264759480212 -0.0732138595467884 0.890560429353369 MirTarget;miRNATAP -0.167465811318093 0.0207986181598012 NA NA NA hsa-miR-660-5p EYA4 -0.561687438133488 0.138270972367544 -0.197703752337886 0.781655040611487 MirTarget -0.392772801151992 0.00280960756402085 NA NA NA hsa-miR-15b-5p EZH1 0.251826642099145 0.790709218602499 -0.193724269076709 0.660390293436418 MirTarget;miRNATAP -0.141844707990391 0.000910286231860889 NA NA NA hsa-miR-15b-5p FAM110C 0.251826642099145 0.790709218602499 -0.15347538293444 0.625000918371107 MirTarget -0.292092530509792 0.000537235774301405 NA NA NA hsa-miR-107 FAM131B -0.289737369453023 0.769655185893943 0.382441463919371 0.19359078713585 MirTarget -0.175347111323393 0.0414063963147316 NA NA NA hsa-miR-127-3p FAM153B 0.231539840651733 0.822108193638849 -0.414540662020779 0.437528262684937 miRanda -0.200238423753366 0.0293215950424697 NA NA NA hsa-miR-128-3p FAM155A -0.0364518492233463 0.95841670253784 0.209472062959562 0.598805237801683 MirTarget -0.357044956469628 0.003730956388736 NA NA NA hsa-miR-150-5p FAM155B -0.00683324482969283 0.994067057151257 0.989778664228366 0.0354877920530956 mirMAP -0.167679416046599 0.00756872249738691 NA NA NA hsa-miR-15b-5p FAM189A1 0.251826642099145 0.790709218602499 0.483057875159079 0.322200061338986 MirTarget;miRNATAP -0.374562210890245 0.0109521002783872 NA NA NA hsa-miR-139-5p FAM84B -0.0625698939687087 0.914810329989088 0.124436502360998 0.841994771676338 PITA;miRanda -0.101785003781032 0.0457002145944639 NA NA NA hsa-miR-107 FAM85A -0.289737369453023 0.769655185893943 -0.120566461469749 0.690106811236555 miRanda -0.202080088870525 0.0110296925350799 NA NA NA hsa-miR-128-3p FAM89A -0.0364518492233463 0.95841670253784 0.32304071425821 0.315343848692809 miRNAWalker2_validate -0.220300327112512 0.00175051386401559 NA NA NA hsa-miR-15b-5p FAM89A 0.251826642099145 0.790709218602499 0.32304071425821 0.315343848692809 MirTarget -0.16912076796158 0.0158723221609869 NA NA NA hsa-miR-140-3p FAM91A1 -0.105651799466207 0.9077781740714 0.105223121156462 0.853062419700926 MirTarget;PITA -0.135140340792551 0.000896086776086797 NA NA NA hsa-miR-107 FAT3 -0.289737369453023 0.769655185893943 0.762334009243 0.17189321629208 MirTarget;PITA;miRanda;miRNATAP -0.37014651922116 0.0249803017657094 NA NA NA hsa-miR-15b-5p FAT3 0.251826642099145 0.790709218602499 0.762334009243 0.17189321629208 MirTarget;miRNATAP -0.36459251374834 0.0329334663096922 NA NA NA hsa-miR-107 FAT4 -0.289737369453023 0.769655185893943 0.148255889034354 0.654798419913443 MirTarget;miRanda;miRNATAP -0.206262479191701 0.0075319136623649 NA NA NA hsa-miR-15b-5p FAT4 0.251826642099145 0.790709218602499 0.148255889034354 0.654798419913443 MirTarget -0.176231991744147 0.0276590078018348 NA NA NA hsa-miR-140-3p FAU -0.105651799466207 0.9077781740714 0.244539229177908 0.744293913708948 miRNAWalker2_validate -0.127848333494784 0.00414479584057294 NA NA NA hsa-miR-107 FBLN1 -0.289737369453023 0.769655185893943 0.576180028523965 0.39905139487406 miRanda -0.270414021956049 0.00345873941896126 NA NA NA hsa-miR-221-3p FBN3 -0.261179092929062 0.744019631321393 -1.10334327423364 0.148225352306687 miRNAWalker2_validate -0.415986837431374 0.0151766294687209 NA NA NA hsa-miR-140-3p FBXO33 -0.105651799466207 0.9077781740714 -0.0164096888222893 0.969517760593863 PITA -0.111953080687489 0.00123849501657192 NA NA NA hsa-miR-127-3p FBXO43 0.231539840651733 0.822108193638849 -0.364241892791967 0.195385510621802 miRanda -0.156382388009273 0.00168652298113014 NA NA NA hsa-miR-107 FCGRT -0.289737369453023 0.769655185893943 -0.106814328214593 0.865431098789263 miRNATAP -0.189108897748901 0.000117101341658099 NA NA NA hsa-miR-140-3p FDXACB1 -0.105651799466207 0.9077781740714 0.180590229567563 0.520616460030375 MirTarget -0.17218709669101 7.27831492288687e-05 NA NA NA hsa-miR-107 FGF2 -0.289737369453023 0.769655185893943 0.058626971450581 0.850374937272804 MirTarget;PITA;miRanda;miRNATAP -0.266744326725375 0.00270703228435517 NA NA NA hsa-miR-15b-5p FGF2 0.251826642099145 0.790709218602499 0.058626971450581 0.850374937272804 MirTarget;miRNATAP -0.248923354978811 0.00692005796687104 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-107 FGF7 -0.289737369453023 0.769655185893943 1.32403482825159 0.0046921040226143 PITA;miRanda;miRNATAP -0.388150038975223 0.0044775884821159 NA NA NA hsa-miR-140-3p FGF9 -0.105651799466207 0.9077781740714 -0.0592815773047637 0.910686490901115 miRNATAP -0.28942620671316 0.0433164836687963 NA NA NA hsa-miR-15b-5p FGF9 0.251826642099145 0.790709218602499 -0.0592815773047637 0.910686490901115 miRNATAP -0.383290064327185 0.0173303753407319 NA NA NA hsa-miR-15b-5p FGFR1 0.251826642099145 0.790709218602499 0.29655955190332 0.660646107767996 miRNATAP -0.19780067325161 0.0176217969881733 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-5p FIBCD1 0.251826642099145 0.790709218602499 0.0725801111921721 0.867473408618604 mirMAP -0.28203316202169 0.0350699323876731 NA NA NA hsa-miR-98-5p FIGN -0.0484028619275874 0.910781316485549 0.0485545645631689 0.910186476245363 MirTarget -0.156397279114503 0.0297077368561123 NA NA NA hsa-miR-197-3p FKBP4 0.0240027695773914 0.981971058073739 -0.00827057781428042 0.99052612769577 miRNAWalker2_validate -0.115746906283958 0.022703683614869 NA NA NA hsa-miR-107 FKBP7 -0.289737369453023 0.769655185893943 0.205347533147915 0.579482063270765 miRanda -0.277632312702028 1.19857259333635e-06 NA NA NA hsa-miR-27a-3p FLRT3 0.309634509674364 0.703724209648479 -0.107534240817507 0.81385125873655 MirTarget;miRNATAP -0.456590451228253 1.28686507719965e-05 NA NA NA hsa-miR-15b-5p FLYWCH1 0.251826642099145 0.790709218602499 -0.133671617869516 0.754955610933496 mirMAP -0.100835199459012 0.013515175783894 NA NA NA hsa-miR-197-3p FMNL2 0.0240027695773914 0.981971058073739 -0.311512370285661 0.562956049165804 miRNATAP -0.102745171199832 0.0258893985127313 NA NA NA hsa-miR-221-3p FNBP1L -0.261179092929062 0.744019631321393 -0.132175775261637 0.819293769680038 mirMAP -0.118058641332911 0.000241677409971907 NA NA NA hsa-miR-222-3p FNBP1L -0.233673471709747 0.726651775432807 -0.132175775261637 0.819293769680038 mirMAP -0.139105124451183 1.18132254980838e-05 NA NA NA hsa-miR-221-3p FNDC3A -0.261179092929062 0.744019631321393 0.0881446526618488 0.867823381527224 MirTarget;miRNATAP -0.115637845718578 0.000296353825132234 NA NA NA hsa-miR-222-3p FNDC3A -0.233673471709747 0.726651775432807 0.0881446526618488 0.867823381527224 MirTarget;miRNATAP -0.135759356747828 1.69538804666545e-05 NA NA NA hsa-miR-107 FNDC4 -0.289737369453023 0.769655185893943 0.486829938341624 0.157978593139745 miRanda -0.344196112048426 7.8034675304698e-06 NA NA NA hsa-miR-15b-5p FOXK1 0.251826642099145 0.790709218602499 -0.33594195315421 0.534710925936459 miRNAWalker2_validate -0.141499735215294 0.0156696450417539 NA NA NA hsa-miR-98-5p FOXO1 -0.0484028619275874 0.910781316485549 0.0524076203087223 0.921148727781111 miRNAWalker2_validate -0.117128048202187 0.00274919240886909 NA NA NA hsa-miR-363-3p FOXP2 -0.186046567396088 0.728622856049059 0.681748078951173 0.255638486836718 miRNATAP -0.200720249840718 0.00943095534509937 NA NA NA hsa-miR-98-5p FOXP2 -0.0484028619275874 0.910781316485549 0.681748078951173 0.255638486836718 MirTarget -0.22225541388062 0.0372905260113753 NA NA NA hsa-miR-128-3p FOXQ1 -0.0364518492233463 0.95841670253784 -0.558622922085247 0.378224255950241 MirTarget -0.292464119583977 0.0341442923286193 NA NA NA hsa-miR-107 FREM2 -0.289737369453023 0.769655185893943 0.511266958584365 0.442454605236576 miRanda -0.604926256562268 0.00214530298579255 NA NA NA hsa-miR-15b-5p FRY 0.251826642099145 0.790709218602499 0.114529189689952 0.774844503144856 miRNATAP -0.177587383785851 0.0144752666902669 NA NA NA hsa-miR-363-3p FRY -0.186046567396088 0.728622856049059 0.114529189689952 0.774844503144856 MirTarget -0.116561423673339 0.000509470800819444 NA NA NA hsa-miR-221-3p FSCN1 -0.261179092929062 0.744019631321393 -0.166097381777673 0.802191165834126 miRNAWalker2_validate -0.218710293595817 0.000186523986063969 NA NA NA hsa-miR-27a-3p FYN 0.309634509674364 0.703724209648479 -0.0572988048973428 0.908461168426155 miRNATAP -0.270104810126542 2.70101207081925e-05 NA NA NA hsa-miR-128-3p G0S2 -0.0364518492233463 0.95841670253784 -0.0824901298409455 0.818781899853032 MirTarget -0.246347232864067 0.00532198790036494 NA NA NA hsa-miR-128-3p G6PC3 -0.0364518492233463 0.95841670253784 0.118005028517512 0.84076483423883 miRNAWalker2_validate -0.127846763788332 0.00222210641485169 NA NA NA hsa-miR-222-3p GAB1 -0.233673471709747 0.726651775432807 0.131313474185227 0.736898982797813 MirTarget;miRNATAP -0.117781298813923 0.00125275843768857 NA NA NA hsa-miR-107 GABBR2 -0.289737369453023 0.769655185893943 0.987433661368056 0.121911531856517 miRanda -0.457530586218331 0.0171473409699305 NA NA NA hsa-miR-221-3p GABRG1 -0.261179092929062 0.744019631321393 0.384291383272049 0.562487846560542 MirTarget -0.580572846540624 1.28635268129421e-05 NA NA NA hsa-miR-222-3p GABRG1 -0.233673471709747 0.726651775432807 0.384291383272049 0.562487846560542 MirTarget -0.600009300902346 5.34792018517211e-06 NA NA NA hsa-miR-148a-3p GADD45A -0.324144803192141 0.746264759480212 0.0120580708134579 0.980879202757005 MirTarget;miRNATAP -0.10683970314889 0.0278518969898176 NA NA NA hsa-miR-148a-3p GAS1 -0.324144803192141 0.746264759480212 0.620352112283554 0.329262575295139 miRNAWalker2_validate -0.156972690369108 0.0430310916983582 NA NA NA hsa-miR-128-3p GAS7 -0.0364518492233463 0.95841670253784 0.415522653953422 0.40610863926007 miRNAWalker2_validate -0.149725529853598 0.0465616951129647 NA NA NA hsa-miR-27a-3p GATC 0.309634509674364 0.703724209648479 -0.146757567893831 0.521310669102217 MirTarget;miRNATAP -0.1676968869639 4.36332555843268e-05 NA NA NA hsa-miR-22-3p GATM 0.0468440219945929 0.967778504781139 0.0952376258924255 0.820377695068492 MirTarget -0.174815664841574 0.00425658701604071 NA NA NA hsa-miR-98-5p GDF6 -0.0484028619275874 0.910781316485549 0.853461935928502 0.0855452478097496 MirTarget -0.218804069562373 0.0240565029197208 NA NA NA hsa-miR-363-3p GFOD1 -0.186046567396088 0.728622856049059 -0.171160331773094 0.664414182012271 mirMAP -0.106815130186124 0.0100395895834844 NA NA NA hsa-miR-363-3p GFPT2 -0.186046567396088 0.728622856049059 0.558234934992865 0.230867215569602 MirTarget;miRNATAP -0.120753030628479 0.0297234981743336 NA NA NA hsa-miR-197-3p GGT7 0.0240027695773914 0.981971058073739 0.142278025918599 0.767680925616585 MirTarget -0.136174785466488 0.0162822122106235 NA NA NA hsa-miR-15b-5p GHR 0.251826642099145 0.790709218602499 0.586796983544641 0.127805103754163 MirTarget;miRNATAP -0.262150204069418 0.0188125091445233 NA NA NA hsa-miR-222-3p GLO1 -0.233673471709747 0.726651775432807 -0.0187868194733642 0.97794028095606 miRNAWalker2_validate -0.136689965401255 7.23163898740591e-05 NA NA NA hsa-miR-150-5p GLP1R -0.00683324482969283 0.994067057151257 0.383368137950096 0.560124884267774 miRNATAP -0.366243521323068 4.38064837779383e-06 NA NA NA hsa-miR-27a-3p GLRA2 0.309634509674364 0.703724209648479 -0.39423020847913 0.575510483632977 miRNATAP -0.476189856775071 0.00174875992217197 NA NA NA hsa-miR-128-3p GLTSCR2 -0.0364518492233463 0.95841670253784 0.115901340635376 0.867588028528667 miRNAWalker2_validate -0.237130885515557 3.69217852552024e-05 NA NA NA hsa-miR-107 GLUD2 -0.289737369453023 0.769655185893943 0.17188444227723 0.671705795296471 PITA;miRanda -0.116809045411901 0.0108365389835986 NA NA NA hsa-miR-15b-5p GNA12 0.251826642099145 0.790709218602499 -0.221602647173709 0.682793287699566 MirTarget -0.101524127512423 0.010364599672756 NA NA NA hsa-miR-107 GNAO1 -0.289737369453023 0.769655185893943 0.744609715084226 0.145113879831662 miRNATAP -0.4315428399075 0.00176040099562656 NA NA NA hsa-miR-27a-3p GNAZ 0.309634509674364 0.703724209648479 0.0593504123341142 0.867226522857799 miRNATAP -0.149788319481537 0.0168214862510012 NA NA NA hsa-miR-27a-3p GNB5 0.309634509674364 0.703724209648479 0.0416571113163142 0.912559266150247 miRNAWalker2_validate -0.109944996705948 0.0091386300113792 NA NA NA hsa-miR-107 GNG10 -0.289737369453023 0.769655185893943 0.375392517682993 0.409458768698038 miRanda -0.149746359232102 0.000228531001831307 NA NA NA hsa-miR-107 GNG12 -0.289737369453023 0.769655185893943 0.235141141957482 0.708841299391704 miRanda -0.164469328667423 0.000680546435738928 NA NA NA hsa-miR-107 GNG4 -0.289737369453023 0.769655185893943 -0.363600123772214 0.41260822441083 miRanda -0.356092592679387 0.00493114490027556 NA NA NA hsa-miR-27a-3p GPAM 0.309634509674364 0.703724209648479 0.265864360002861 0.485918851699878 miRNAWalker2_validate;MirTarget;miRNATAP -0.127147011922395 0.00396053768129452 NA NA NA hsa-miR-22-3p GPBP1 0.0468440219945929 0.967778504781139 -0.0295484367138661 0.957497175654481 MirTarget;miRNATAP -0.107909576703091 9.54312937441129e-05 NA NA NA hsa-miR-107 GPC6 -0.289737369453023 0.769655185893943 0.698986982223014 0.147090989195263 MirTarget;PITA;miRanda;miRNATAP -0.440795591534833 6.53077786788182e-05 NA NA NA hsa-miR-214-3p GPD1L 0.0312810611346688 0.952640488671912 0.219982362832661 0.658605955673438 MirTarget -0.105338483551295 7.86431388313804e-05 NA NA NA hsa-miR-107 GPR12 -0.289737369453023 0.769655185893943 0.558702940522461 0.522237505895456 miRanda -0.59523126178609 0.0241489459600571 NA NA NA hsa-miR-127-3p GPR82 0.231539840651733 0.822108193638849 0.0251765521044952 0.951089705510675 miRanda -0.174313881113702 0.0184121631025044 NA NA NA hsa-miR-107 GPRASP2 -0.289737369453023 0.769655185893943 -0.310886487837366 0.31158390708351 miRanda -0.133622392957859 0.0226297200837348 NA NA NA hsa-miR-214-3p GPT2 0.0312810611346688 0.952640488671912 -0.21054653782482 0.691123984160395 mirMAP -0.161288926354262 3.50792688645314e-07 NA NA NA hsa-miR-107 GPX8 -0.289737369453023 0.769655185893943 0.25848032086646 0.626347410967487 miRanda -0.154174349960053 0.00428327144511538 NA NA NA hsa-miR-214-3p GRAMD2 0.0312810611346688 0.952640488671912 0.0247731084081293 0.960752351834024 mirMAP -0.168774585743075 0.00427573407239812 NA NA NA hsa-miR-222-3p GRB10 -0.233673471709747 0.726651775432807 -0.205639469828889 0.666151118942152 miRNAWalker2_validate -0.139329267033803 0.000663551907010256 NA NA NA hsa-miR-107 GREM2 -0.289737369453023 0.769655185893943 0.545447047262879 0.24874844075317 PITA;miRanda;miRNATAP -0.326557033802583 0.0197028703366794 NA NA NA hsa-miR-140-3p GRHL2 -0.105651799466207 0.9077781740714 -0.121964332294207 0.816948639211559 MirTarget;PITA -0.231860596709879 0.0004439817875923 NA NA NA hsa-miR-15b-5p GRM7 0.251826642099145 0.790709218602499 -0.62779723663181 0.23049165718907 MirTarget;miRNATAP -0.538785108020064 0.000334092274701787 NA NA NA hsa-miR-140-3p GSK3A -0.105651799466207 0.9077781740714 -0.0635174447391869 0.919293004596672 PITA -0.127585225294829 0.000409671022218889 NA NA NA hsa-miR-214-3p GSTM2 0.0312810611346688 0.952640488671912 0.178404406146088 0.71708042042517 mirMAP -0.163006615498704 0.00036808773541537 NA NA NA hsa-miR-150-5p GSTM3 -0.00683324482969283 0.994067057151257 -0.058828001311694 0.902691633028036 mirMAP -0.198962421601053 7.99236273943993e-06 NA NA NA hsa-miR-107 GSTM5 -0.289737369453023 0.769655185893943 -0.539613076086012 0.230113514454763 miRanda -0.616301751474425 3.14299394298076e-06 NA NA NA hsa-miR-221-3p GTF2E1 -0.261179092929062 0.744019631321393 -0.0457926616512019 0.903172294017755 miRNAWalker2_validate -0.108990800110252 5.98907318831052e-06 NA NA NA hsa-miR-222-3p GTF3C4 -0.233673471709747 0.726651775432807 -0.187370685144983 0.655496554038728 mirMAP -0.119545443237958 0.000187795421631742 NA NA NA hsa-miR-140-3p GTPBP3 -0.105651799466207 0.9077781740714 -0.0715205429104717 0.865101123343378 MirTarget -0.147778873629085 0.00157869819249191 NA NA NA hsa-miR-27a-3p GXYLT1 0.309634509674364 0.703724209648479 0.0309454668772027 0.939527543534158 miRNATAP -0.114761311193716 0.00313416614408988 NA NA NA hsa-miR-107 GYPC -0.289737369453023 0.769655185893943 0.201621761713326 0.661673470535131 miRanda -0.216696946806115 0.00222254075824663 NA NA NA hsa-miR-128-3p H3F3C -0.0364518492233463 0.95841670253784 0.164197212368519 0.452288039469947 MirTarget -0.14333785027558 0.0201399634924399 NA NA NA hsa-miR-222-3p HAUS8 -0.233673471709747 0.726651775432807 -0.0907218799412601 0.798031922786145 miRNAWalker2_validate -0.159782576890934 0.000187818741677209 NA NA NA hsa-miR-27a-3p HCN4 0.309634509674364 0.703724209648479 -0.070999348466067 0.890135374463602 miRNATAP -0.329499124212177 0.0130473899228146 NA NA NA hsa-miR-22-3p HDAC4 0.0468440219945929 0.967778504781139 -0.275592349037378 0.542250148863867 miRNAWalker2_validate;miRTarBase;miRNATAP -0.123918964828771 0.00279384427648962 20842113 Furthermore histone deacetylase 4 HDAC4 known to have critical roles in cancer development was proved to be directly targeted and regulated by miR-22; Furthermore HDAC4 was upregulated in miR-22-downregulated HCC tissues suggesting that downregulation of miR-22 might participate in HCC carcinogenesis and progression through potentiation of HDAC4 expression progression;tumorigenesis liver cancer hsa-miR-107 HEBP1 -0.289737369453023 0.769655185893943 -0.15117497195037 0.75605907650992 miRanda -0.146534297817916 0.000631580711404125 NA NA NA hsa-miR-214-3p HES6 0.0312810611346688 0.952640488671912 0.148676660737039 0.712519544282552 mirMAP -0.105312388449972 0.0236761904711796 NA NA NA hsa-miR-128-3p HIC1 -0.0364518492233463 0.95841670253784 -0.0344480987639861 0.931632461442992 MirTarget -0.199744745358745 0.0191302863400068 NA NA NA hsa-miR-150-5p HIF3A -0.00683324482969283 0.994067057151257 0.146506883407749 0.810382163502263 mirMAP -0.162607229788463 0.0262204572560258 NA NA NA hsa-miR-98-5p HIF3A -0.0484028619275874 0.910781316485549 0.146506883407749 0.810382163502263 mirMAP -0.392738832339778 9.85540640707651e-05 NA NA NA hsa-miR-127-3p HINT2 0.231539840651733 0.822108193638849 0.144304126286809 0.749472380534025 miRanda -0.164690368037114 1.26844395865931e-06 NA NA NA hsa-miR-15b-5p HIPK2 0.251826642099145 0.790709218602499 -0.287025072753059 0.646492190124924 miRNATAP -0.133580120011527 0.024610961247001 NA NA NA hsa-miR-27a-3p HIPK2 0.309634509674364 0.703724209648479 -0.287025072753059 0.646492190124924 miRNAWalker2_validate;miRNATAP -0.14304582862511 0.00420208546643711 20646448;20624637 2 A2780/Taxol cells transfection with inhibitors of miR-27a showed that the levels of MDR1 mRNA was decreased by 39% P-gp protein level 26+/-5% decreased than that in the NC group 43+/-7% HIPK2 protein level 30+/-6% increased than that in the NC group 19+/-4% the 50% inhibition concentration 0.5 micromol/L was less than that in the NC group 6.8 micromol/L apoptosis rate 32.5+/-3.6% was higher than that in the NC group 5.6+/-2.1% and there were significant differences between two groups all P<0.05; The expression of miR-27a is upregulated in A2780/Taxol cells which may regulate MDR1 and P-gp expression by targeting HIPK2;MiR 27a modulates MDR1/P glycoprotein expression by targeting HIPK2 in human ovarian cancer cells; Transfection of A2780/Taxol cells with the inhibitors of miR-27a decreased the expression of MDR1 mRNA and P-gp protein increased HIPK2 protein expression enhanced the sensitivity of A2780/taxol cells to paclitaxel increased paclitaxel-induced apoptosis and the fluorescence intensity of intracellular Rh-123; The deregulation of miR-27a may be involved in the development of drug resistance regulating the expression of MDR1/P-gp at least in part by targeting HIPK2 in ovarian cancer cells ;drug resistance ovarian cancer;ovarian cancer hsa-miR-221-3p HIST2H2AC -0.261179092929062 0.744019631321393 0.288073545766011 0.398519682365324 miRNAWalker2_validate -0.212608918092888 0.00294169058639804 NA NA NA hsa-miR-107 HLF -0.289737369453023 0.769655185893943 -0.406565963148618 0.262525428348243 PITA;miRNATAP -0.236371987575107 0.0258972032101061 NA NA NA hsa-miR-221-3p HMBOX1 -0.261179092929062 0.744019631321393 0.0325822504351332 0.903694982022734 MirTarget;miRNATAP -0.109238318928543 0.00858497785978992 NA NA NA hsa-miR-222-3p HMBOX1 -0.233673471709747 0.726651775432807 0.0325822504351332 0.903694982022734 MirTarget;miRNATAP -0.114630334042755 0.00540773918139505 NA NA NA hsa-miR-15b-5p HMGA2 0.251826642099145 0.790709218602499 -0.495870455398845 0.474353706194245 MirTarget -0.565202280018764 0.00246420417765114 NA NA NA hsa-miR-98-5p HMGA2 -0.0484028619275874 0.910781316485549 -0.495870455398845 0.474353706194245 miRNAWalker2_validate;miRTarBase;MirTarget -0.3656549955416 0.00218393467641425 17222355;23700794 Here we report that HMGA2 expression in head and neck squamous cell carcinoma HNSCC cells is regulated in part by miRNA-98 miR-98;MicroRNA 98 sensitizes cisplatin resistant human lung adenocarcinoma cells by up regulation of HMGA2; MiR-98 a member in the let-7 family acts as a negative regulator in the expression of HMGA2 high mobility group A2 oncogene and it has been shown to have a nearly 3-fold decrease in A549/DDP cells; We found that elevated expression of miR-98 led to a higher sensitivity of A549/DDP cells to cisplatin and the protein level of HMGA2 was clearly up-regulated in both A549/DDP and A549 cells by miR-98; We for the first time demonstrated that the expression of miR-98 increases cells spontaneous apoptosis and sensitizes cells to cisplatin at least in part via HMGA2 up-regulation ; head and neck cancer;lung cancer hsa-miR-148a-3p HMGB1 -0.324144803192141 0.746264759480212 0.0376071736611054 0.957155680367252 miRNAWalker2_validate -0.127033208854852 7.27023134780739e-06 NA NA NA hsa-miR-22-3p HMGB1 0.0468440219945929 0.967778504781139 0.0376071736611054 0.957155680367252 miRNAWalker2_validate -0.112621671900166 4.10533914896381e-05 24609901;24752578 However possibly as a compensatory effect miR-22 was also upregulated during the chemotherapy and the overexpressed miR-22 targeted the 3' UTR of HMGB1 and inhibits the HMGB1-promoted autophagy; Our study suggests a complexity in the regulation of autophagy by miR-22 and HMGB1 during chemotherapy resistance in osteosarcoma;In this study we determined the targeting role of miR-22 to HMGB1 and the regulation of miR-22 on the HMGB1-mediated cell autophagy and on the cell proliferation migration and invasion of osteosarcoma cells drug resistance; sarcoma;sarcoma hsa-miR-127-3p HMGCL 0.231539840651733 0.822108193638849 0.0909133155599902 0.851479192791536 miRanda -0.168006519273437 9.49843480411152e-11 NA NA NA hsa-miR-140-3p HMGN1 -0.105651799466207 0.9077781740714 0.0843399498957567 0.894287532642448 miRNATAP -0.121406570810038 0.000356768507897872 NA NA NA hsa-miR-140-3p HMGN3 -0.105651799466207 0.9077781740714 0.173834628633814 0.760448721379763 PITA;miRNATAP -0.152515466420663 0.000709178176066654 NA NA NA hsa-miR-214-3p HMGN3 0.0312810611346688 0.952640488671912 0.173834628633814 0.760448721379763 miRNATAP -0.127699729283976 1.02249859521777e-06 NA NA NA hsa-miR-150-5p HNF1A -0.00683324482969283 0.994067057151257 -0.599780281038367 0.0463852812396608 mirMAP -0.198864168768169 1.57332747748628e-06 NA NA NA hsa-miR-15b-5p HNF1A 0.251826642099145 0.790709218602499 -0.599780281038367 0.0463852812396608 mirMAP -0.289445654410361 0.0014872298899797 NA NA NA hsa-miR-197-3p HNRNPA1 0.0240027695773914 0.981971058073739 0.324357344981395 0.646474695150591 miRNAWalker2_validate -0.107511652466325 0.00400720611419532 NA NA NA hsa-miR-107 HOPX -0.289737369453023 0.769655185893943 0.312349411044829 0.499613152004287 miRanda -0.215543808581572 0.0162612185420359 NA NA NA hsa-miR-27a-3p HOXC11 0.309634509674364 0.703724209648479 0.0406709827527383 0.955573595094228 miRNATAP -0.365338289322512 0.017688783785241 NA NA NA hsa-miR-214-3p HOXC4 0.0312810611346688 0.952640488671912 0.570064880006255 0.26273503625506 miRNATAP -0.14326585233287 0.0132546013433304 NA NA NA hsa-miR-150-5p HPSE2 -0.00683324482969283 0.994067057151257 1.04276198085754 0.183067657657017 MirTarget -0.347352216867203 0.000300250703674567 NA NA NA hsa-miR-15b-5p HPSE2 0.251826642099145 0.790709218602499 1.04276198085754 0.183067657657017 MirTarget -0.612751379670714 0.00349892342779719 NA NA NA hsa-miR-214-3p HPSE2 0.0312810611346688 0.952640488671912 1.04276198085754 0.183067657657017 MirTarget -0.247103395065671 0.024134354605581 NA NA NA hsa-miR-222-3p HSPA14 -0.233673471709747 0.726651775432807 -0.0686296948376199 0.877982742102929 miRNAWalker2_validate -0.140220146429936 2.11317164961284e-06 NA NA NA hsa-miR-98-5p HSPB7 -0.0484028619275874 0.910781316485549 0.680516360685846 0.0824688640822675 miRNAWalker2_validate -0.142505448745325 0.0488960776237782 NA NA NA hsa-miR-214-3p HSPD1 0.0312810611346688 0.952640488671912 -0.102889357474595 0.886223639469787 miRNAWalker2_validate -0.109200704145466 4.15357488678914e-07 NA NA NA hsa-miR-15b-5p HSPG2 0.251826642099145 0.790709218602499 -0.0549567717778192 0.945061296685726 MirTarget -0.138457976550672 0.0429957992481835 NA NA NA hsa-miR-127-3p HTR3A 0.231539840651733 0.822108193638849 0.408755916833218 0.590337544234306 miRanda -0.252636662940679 0.0395516167599594 NA NA NA hsa-miR-139-5p HYDIN -0.0625698939687087 0.914810329989088 -0.293171348826773 0.500530184320928 miRanda -0.160743868264919 0.0478765051008873 NA NA NA hsa-miR-107 ID2 -0.289737369453023 0.769655185893943 -0.035243584091373 0.948581601574187 miRanda -0.284955473257002 8.36366764569542e-06 NA NA NA hsa-miR-27a-3p ID2 0.309634509674364 0.703724209648479 -0.035243584091373 0.948581601574187 MirTarget;miRNATAP -0.15734584861054 0.0052530037383378 NA NA NA hsa-miR-127-3p IDO1 0.231539840651733 0.822108193638849 -0.399635110883189 0.532606564069925 miRanda -0.313610820173607 0.00135375917718075 NA NA NA hsa-miR-107 IDS -0.289737369453023 0.769655185893943 0.00659697334470977 0.991911950215013 miRanda -0.110406419437008 0.011872595935368 NA NA NA hsa-miR-150-5p IGDCC3 -0.00683324482969283 0.994067057151257 -0.131145753107458 0.8547106150508 mirMAP -0.574765877794648 2.31687625271158e-09 NA NA NA hsa-miR-98-5p IGDCC3 -0.0484028619275874 0.910781316485549 -0.131145753107458 0.8547106150508 MirTarget -0.454800217661095 0.000875784818487051 NA NA NA hsa-miR-107 IGDCC4 -0.289737369453023 0.769655185893943 -0.196249749405944 0.598311767163085 miRanda -0.276045351833311 0.00337169607061605 NA NA NA hsa-miR-148a-3p IGDCC4 -0.324144803192141 0.746264759480212 -0.196249749405944 0.598311767163085 miRNATAP -0.223917620075446 0.00273848398756855 NA NA NA hsa-miR-98-5p IGDCC4 -0.0484028619275874 0.910781316485549 -0.196249749405944 0.598311767163085 MirTarget -0.158125405490403 0.0113010517829518 NA NA NA hsa-miR-139-5p IGF1R -0.0625698939687087 0.914810329989088 0.181844503809824 0.77996203041897 miRNAWalker2_validate;miRTarBase;MirTarget;PITA -0.174106272129585 0.00896722597597466 26097570 Furthermore we identified insulin-like growth factor 1 receptor IGF1R as a target of miR-139-5p and miR-139-5p function as a tumor suppressor via targeting IGF1R in NSCLC; Our results indicated that miR-139-5p acts as a tumor suppressor in NSCLC partially via down-regulating IGF1R expression lung squamous cell cancer hsa-miR-140-3p IGF1R -0.105651799466207 0.9077781740714 0.181844503809824 0.77996203041897 mirMAP -0.154595141171486 0.0396588059668609 24039995 Integrated analysis identified IGF1R as a direct and functional target of miR-140; Knockdown of IGF1R inhibited cell proliferation and invasion resembling that of miR-140 overexpression while overexpression of IGF1R attenuated the function of miR-140 in NSCLC cells; Together our results highlight the significance of miR-140 and IGF1R in the development and progression of NSCLC progression lung squamous cell cancer hsa-miR-150-5p IGF1R -0.00683324482969283 0.994067057151257 0.181844503809824 0.77996203041897 mirMAP -0.18117811369085 2.23430163003899e-06 NA NA NA hsa-miR-15b-5p IGF1R 0.251826642099145 0.790709218602499 0.181844503809824 0.77996203041897 miRNATAP -0.317779005119476 0.000151662468233773 NA NA NA hsa-miR-27a-3p IGF1R 0.309634509674364 0.703724209648479 0.181844503809824 0.77996203041897 mirMAP -0.163745983586904 0.0215914331883283 NA NA NA hsa-miR-98-5p IGF1R -0.0484028619275874 0.910781316485549 0.181844503809824 0.77996203041897 MirTarget -0.110364533529799 0.0413819473384427 NA NA NA hsa-miR-148a-3p IGF2 -0.324144803192141 0.746264759480212 -0.00189647616083555 0.998651871055033 mirMAP -0.576587947047826 0.00424891563780717 NA NA NA hsa-miR-98-5p IGF2BP1 -0.0484028619275874 0.910781316485549 -0.284459156903399 0.684218447229109 MirTarget -0.301883147850632 0.0289552696686835 NA NA NA hsa-miR-27a-3p IGLON5 0.309634509674364 0.703724209648479 0.721021227238998 0.265049722736949 MirTarget;miRNATAP -0.3319549314825 0.0490084742440482 NA NA NA hsa-miR-15b-5p IGSF9B 0.251826642099145 0.790709218602499 0.3027723021916 0.563453652432104 mirMAP -0.365261895269685 0.022964485998494 NA NA NA hsa-miR-150-5p IHH -0.00683324482969283 0.994067057151257 -0.239196523021247 0.741788210234923 miRNATAP -0.557858949959687 5.3698418143045e-10 NA NA NA hsa-miR-15b-5p IHH 0.251826642099145 0.790709218602499 -0.239196523021247 0.741788210234923 MirTarget;miRNATAP -0.686474802966716 0.000598466283027087 NA NA NA hsa-miR-139-5p IKBKB -0.0625698939687087 0.914810329989088 -0.241085468681219 0.630606951636123 miRanda -0.11477273652595 0.00111240774729446 NA NA NA hsa-miR-148a-3p IL17RD -0.324144803192141 0.746264759480212 -0.0837567037988727 0.870962136224886 miRNATAP -0.163603919776108 0.0110307354480661 NA NA NA hsa-miR-150-5p IL17RD -0.00683324482969283 0.994067057151257 -0.0837567037988727 0.870962136224886 mirMAP -0.171106826170488 7.11913006567918e-06 NA NA NA hsa-miR-22-3p IL17RD 0.0468440219945929 0.967778504781139 -0.0837567037988727 0.870962136224886 MirTarget;miRNATAP -0.300302259370387 9.64911303374779e-07 NA NA NA hsa-miR-139-5p ILDR1 -0.0625698939687087 0.914810329989088 0.0445237863089369 0.915777291538141 miRanda -0.138247620492926 0.00459129190284946 NA NA NA hsa-miR-221-3p INA -0.261179092929062 0.744019631321393 -0.389856424611482 0.485952218559766 MirTarget;miRNATAP -0.441784902604437 0.000623856859846905 NA NA NA hsa-miR-222-3p INA -0.233673471709747 0.726651775432807 -0.389856424611482 0.485952218559766 MirTarget -0.443870764233659 0.000529697200786564 NA NA NA hsa-miR-214-3p ING4 0.0312810611346688 0.952640488671912 0.08563728606146 0.865248448223296 miRTarBase -0.117834462627946 1.14759075839732e-05 NA NA NA hsa-miR-150-5p ING5 -0.00683324482969283 0.994067057151257 -0.442327758599586 0.29264132475739 mirMAP -0.12846262886785 1.12672813154626e-08 NA NA NA hsa-miR-27a-3p ING5 0.309634509674364 0.703724209648479 -0.442327758599586 0.29264132475739 MirTarget;miRNATAP -0.123214071529203 0.00343673864786576 NA NA NA hsa-miR-107 INMT -0.289737369453023 0.769655185893943 0.227986011911441 0.536094203946461 miRanda -0.290214657869074 0.00565469334423472 NA NA NA hsa-miR-139-5p INPP5J -0.0625698939687087 0.914810329989088 -0.45205349346122 0.193882293272043 miRanda -0.145130011632209 0.0132453143404039 NA NA NA hsa-miR-222-3p IPO5 -0.233673471709747 0.726651775432807 -0.0469735621627194 0.943180179467306 miRNAWalker2_validate -0.138431473786496 2.6999922065134e-05 NA NA NA hsa-miR-221-3p IPO9 -0.261179092929062 0.744019631321393 -0.0424977885749938 0.944515767790151 mirMAP -0.135710374620127 3.16220925948726e-07 NA NA NA hsa-miR-222-3p IPO9 -0.233673471709747 0.726651775432807 -0.0424977885749938 0.944515767790151 mirMAP -0.141870862704971 6.59493928708857e-08 NA NA NA hsa-miR-107 IRF2BP1 -0.289737369453023 0.769655185893943 -0.0851195783672098 0.874408687303578 miRNATAP -0.18741927495551 1.50377641281313e-05 NA NA NA hsa-miR-148a-3p IRS1 -0.324144803192141 0.746264759480212 -0.0224800910783998 0.964603432953669 miRNAWalker2_validate;miRTarBase -0.157041973286888 0.00893965311584429 NA NA NA hsa-miR-107 IRS2 -0.289737369453023 0.769655185893943 0.297506911350594 0.603092879996597 PITA;miRanda;miRNATAP -0.25288129039537 0.00183250034356889 NA NA NA hsa-miR-98-5p IRS2 -0.0484028619275874 0.910781316485549 0.297506911350594 0.603092879996597 miRNAWalker2_validate;MirTarget -0.147657600810698 0.00605619946566084 NA NA NA hsa-miR-107 ISLR -0.289737369453023 0.769655185893943 0.461095099214968 0.497624223366267 miRNATAP -0.267842032890862 0.00893137963477742 NA NA NA hsa-miR-128-3p ISLR -0.0364518492233463 0.95841670253784 0.461095099214968 0.497624223366267 MirTarget -0.271834545945407 0.0109304824722465 NA NA NA hsa-miR-15b-5p ISLR 0.251826642099145 0.790709218602499 0.461095099214968 0.497624223366267 MirTarget;miRNATAP -0.249973255742229 0.0184977270612957 NA NA NA hsa-miR-148a-3p ISM1 -0.324144803192141 0.746264759480212 0.769885409879741 0.103585462607808 miRNATAP -0.230186412842318 0.0178114778547806 NA NA NA hsa-miR-214-3p ISM2 0.0312810611346688 0.952640488671912 -0.447985764857535 0.366274369255956 mirMAP -0.183684773326737 0.0210175327539833 NA NA NA hsa-miR-140-3p ITFG2 -0.105651799466207 0.9077781740714 0.063314020954091 0.896957600465477 MirTarget -0.102812098769551 0.0251423608422636 NA NA NA hsa-miR-15b-5p ITGA10 0.251826642099145 0.790709218602499 -0.0268966871664938 0.934103534101151 MirTarget -0.23080291613485 0.0196697292205923 NA NA NA hsa-miR-107 ITGBL1 -0.289737369453023 0.769655185893943 1.06516210037955 0.0749037459510402 miRanda -0.497462176737539 0.00481711960703225 NA NA NA hsa-miR-107 ITM2A -0.289737369453023 0.769655185893943 0.0833868250902436 0.82186549829893 miRanda -0.285094427221194 0.000335649954164568 NA NA NA hsa-miR-15b-5p ITPR1 0.251826642099145 0.790709218602499 -0.129629234763097 0.738254587356145 MirTarget;miRNATAP -0.136670849880866 0.0475770418655366 NA NA NA hsa-miR-15b-5p IVNS1ABP 0.251826642099145 0.790709218602499 -0.0568292701092341 0.92742211373667 MirTarget -0.104892194197954 0.01081923177017 NA NA NA hsa-miR-15b-5p JARID2 0.251826642099145 0.790709218602499 -0.188189262266655 0.679298581855395 MirTarget;miRNATAP -0.133974958189078 0.0204861110476628 NA NA NA hsa-miR-22-3p JARID2 0.0468440219945929 0.967778504781139 -0.188189262266655 0.679298581855395 miRNATAP -0.174613800929565 3.93215635377854e-05 NA NA NA hsa-miR-148a-3p JPH3 -0.324144803192141 0.746264759480212 -0.620590433652452 0.344974424522281 miRNATAP -0.314706607143168 0.0434690662966255 NA NA NA hsa-miR-27a-3p KCNA6 0.309634509674364 0.703724209648479 0.488516332017855 0.324924076717191 MirTarget -0.268828255659389 0.0374071362841579 NA NA NA hsa-miR-98-5p KCNA6 -0.0484028619275874 0.910781316485549 0.488516332017855 0.324924076717191 mirMAP -0.268773391419768 0.00593673180634528 NA NA NA hsa-miR-15b-5p KCNC1 0.251826642099145 0.790709218602499 0.0449547611912151 0.929136954680909 mirMAP -0.305225473034932 0.0248350568218567 NA NA NA hsa-miR-22-3p KCNC1 0.0468440219945929 0.967778504781139 0.0449547611912151 0.929136954680909 miRNATAP -0.362789626503336 0.000294608788651507 NA NA NA hsa-miR-107 KCNIP1 -0.289737369453023 0.769655185893943 0.0418634328515107 0.945869777268282 MirTarget;miRanda -0.470191792991668 0.0106550954093395 NA NA NA hsa-miR-150-5p KCNIP1 -0.00683324482969283 0.994067057151257 0.0418634328515107 0.945869777268282 MirTarget;miRNATAP -0.386018138695552 8.25785151227497e-06 NA NA NA hsa-miR-15b-5p KCNIP1 0.251826642099145 0.790709218602499 0.0418634328515107 0.945869777268282 MirTarget -0.407013863741538 0.0329544013246179 NA NA NA hsa-miR-214-3p KCNIP3 0.0312810611346688 0.952640488671912 -0.395627468269231 0.366755156433478 mirMAP -0.134985231732185 0.00799339061290436 NA NA NA hsa-miR-107 KCNIP4 -0.289737369453023 0.769655185893943 0.0361117044945495 0.915681005481963 miRanda -0.231162979782349 0.0207151352107455 NA NA NA hsa-miR-214-3p KCNJ11 0.0312810611346688 0.952640488671912 -0.354625483231593 0.230626092648994 mirMAP -0.153423458267942 9.23081154928086e-05 NA NA NA hsa-miR-150-5p KCNJ12 -0.00683324482969283 0.994067057151257 0.0346871570737179 0.938318748638831 mirMAP -0.141205770109722 0.0130338450460305 NA NA NA hsa-miR-107 KCNK1 -0.289737369453023 0.769655185893943 0.174143902690535 0.685930560270308 miRanda -0.188160819642605 0.0109898520859398 NA NA NA hsa-miR-15b-5p KCNK3 0.251826642099145 0.790709218602499 0.0285178702321485 0.953451017519098 mirMAP -0.505098752069605 0.000424765513039642 NA NA NA hsa-miR-27a-3p KCNK3 0.309634509674364 0.703724209648479 0.0285178702321485 0.953451017519098 mirMAP -0.302783555963427 0.0126823729102048 NA NA NA hsa-miR-381-3p KCNMB2 0.269633663970002 0.562625029053898 0.208236732160485 0.651153545808377 MirTarget -0.197848588857467 0.0201384647899008 NA NA NA hsa-miR-107 KCNN4 -0.289737369453023 0.769655185893943 0.346381357032025 0.48013118024966 MirTarget;miRanda;miRNATAP -0.279794464422368 0.0248428011346287 NA NA NA hsa-miR-107 KCNT2 -0.289737369453023 0.769655185893943 -0.030446953926676 0.942722530787762 miRanda -0.272433801065968 0.0315326043545785 NA NA NA hsa-miR-150-5p KDM5B -0.00683324482969283 0.994067057151257 0.0477380054298591 0.937073866443259 MirTarget -0.129795842646146 8.54129077377513e-08 NA NA NA hsa-miR-150-5p KIAA0895L -0.00683324482969283 0.994067057151257 -0.259582911935119 0.480275217430713 MirTarget -0.105100963244966 0.000150397418688473 NA NA NA hsa-miR-127-3p KIAA0907 0.231539840651733 0.822108193638849 -0.336399778058736 0.531252699795224 miRanda -0.106796800687829 6.36918029198336e-06 NA NA NA hsa-miR-27a-3p KIAA1210 0.309634509674364 0.703724209648479 0.639834659401867 0.252097233883892 MirTarget -0.35544282181838 0.0148411461132273 NA NA NA hsa-miR-22-3p KIAA1257 0.0468440219945929 0.967778504781139 -0.176569610521038 0.605655150830703 mirMAP -0.285836979569127 0.00021029791594567 NA NA NA hsa-miR-660-5p KIAA1324L -0.561687438133488 0.138270972367544 0.633500734696163 0.178357474167354 MirTarget -0.193347436411658 0.020721058971908 NA NA NA hsa-miR-148a-3p KIAA1644 -0.324144803192141 0.746264759480212 0.706029111299509 0.143146152697486 mirMAP -0.473877308901702 2.59800115805737e-05 NA NA NA hsa-miR-27a-3p KIAA2022 0.309634509674364 0.703724209648479 -0.513184227302334 0.28975747914921 miRNATAP -0.293424869398033 0.0187310647122244 NA NA NA hsa-miR-107 KIF13B -0.289737369453023 0.769655185893943 -0.119827616199206 0.791700468200055 mirMAP -0.121488659001467 0.0295224662599821 NA NA NA hsa-miR-15b-5p KIF1C 0.251826642099145 0.790709218602499 -0.19380663203288 0.754275365507274 miRNATAP -0.114585733398954 0.0135303648721741 NA NA NA hsa-miR-140-3p KIF21A -0.105651799466207 0.9077781740714 -0.0146418276057512 0.971849807866891 miRNAWalker2_validate -0.141414038994353 0.00833531481221926 NA NA NA hsa-miR-98-5p KIF21B -0.0484028619275874 0.910781316485549 -0.687581204556475 0.0316752721293158 mirMAP -0.132662291613362 0.00571596491000681 NA NA NA hsa-miR-22-3p KIF6 0.0468440219945929 0.967778504781139 -0.18634088212664 0.56919306846748 mirMAP -0.199720537693854 0.00571370946047905 NA NA NA hsa-miR-15b-5p KIRREL 0.251826642099145 0.790709218602499 -0.464996657308794 0.357002291272135 mirMAP -0.206298793244936 0.00236587116880985 NA NA NA hsa-miR-22-3p KIRREL3 0.0468440219945929 0.967778504781139 -0.26770541854455 0.650274388437893 MirTarget;miRNATAP -0.72484556173782 2.18005714700607e-08 NA NA NA hsa-miR-128-3p KIT -0.0364518492233463 0.95841670253784 -0.249221513956445 0.534286727599588 MirTarget -0.363356596326259 0.00307640966311547 NA NA NA hsa-miR-221-3p KIT -0.261179092929062 0.744019631321393 -0.249221513956445 0.534286727599588 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.283844538803818 0.00215385132092908 NA NA NA hsa-miR-222-3p KIT -0.233673471709747 0.726651775432807 -0.249221513956445 0.534286727599588 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.26432386719203 0.00401569380370608 NA NA NA hsa-miR-15b-5p KLC4 0.251826642099145 0.790709218602499 -0.110966849190025 0.803478523433492 miRNATAP -0.147389783263023 0.00146565389708043 NA NA NA hsa-miR-660-5p KLF12 -0.561687438133488 0.138270972367544 -0.107461049696606 0.79612046968107 mirMAP -0.137279748476102 0.000431308344835292 NA NA NA hsa-miR-27a-3p KLHDC3 0.309634509674364 0.703724209648479 0.0387392356539085 0.951213672188197 miRNATAP -0.161009505380736 4.51534545013357e-05 NA NA NA hsa-miR-150-5p KLHDC7A -0.00683324482969283 0.994067057151257 -0.994594569515364 0.150801770627861 MirTarget -0.34699560802752 0.000397295578748116 NA NA NA hsa-miR-15b-5p KLHDC8B 0.251826642099145 0.790709218602499 0.0454131157340809 0.918204980978242 MirTarget -0.113061740181551 0.0141064369951752 NA NA NA hsa-miR-139-5p KLHL32 -0.0625698939687087 0.914810329989088 0.525800535583096 0.14623328382037 miRanda -0.189841398607915 0.0300716357516406 NA NA NA hsa-miR-107 KNDC1 -0.289737369453023 0.769655185893943 0.176943515244534 0.758285234329918 miRanda -0.56883052343834 0.000930541047870098 NA NA NA hsa-miR-27a-3p KRAS 0.309634509674364 0.703724209648479 0.0135426868156925 0.98016869715642 miRNATAP -0.15119388054973 0.00919299839947551 24154848;25436011 microRNA 27a functions as a tumor suppressor in esophageal squamous cell carcinoma by targeting KRAS; Furthermore we demonstrated that miR-27a binds to the 3'-untranslated region UTR of KRAS and inhibits the expression of the KRAS protein; miR-27a levels were inversely correlated with levels of KRAS mRNA and protein in ESCC specimens; Our findings suggest for the first time that miR-27a suppresses tumorigenesis of ESCC by targeting KRAS;MicroRNA 27a directly targets KRAS to inhibit cell proliferation in esophageal squamous cell carcinoma; However the expression level of the target gene KRAS was upregulated and ESCC cell proliferation was significantly inhibited following miR-27a mimic or small interfering K-ras transfection; In conclusion the present study demonstrated that the expression level of miR-27a was low in ESCC and that miR-27a directly targets the KRAS gene resulting in inhibited cell proliferation in esophageal cancer tumorigenesis; esophageal cancer;esophageal cancer hsa-miR-139-5p KSR2 -0.0625698939687087 0.914810329989088 0.014552829135464 0.969087101509327 mirMAP -0.152695827615477 0.0479008270184896 NA NA NA hsa-miR-150-5p KSR2 -0.00683324482969283 0.994067057151257 0.014552829135464 0.969087101509327 mirMAP -0.129187390943998 0.003926928862325 NA NA NA hsa-miR-214-3p KY 0.0312810611346688 0.952640488671912 0.244492131660401 0.625929595987601 MirTarget -0.15847153452531 0.0487967178001024 NA NA NA hsa-miR-140-3p L2HGDH -0.105651799466207 0.9077781740714 -0.019312853149092 0.960282106984546 MirTarget -0.13974811900873 0.000740678187943566 NA NA NA hsa-miR-127-3p L3MBTL4 0.231539840651733 0.822108193638849 0.157146106434107 0.700533498651459 miRanda -0.157980757591556 0.0196705496421523 NA NA NA hsa-miR-107 LAPTM4A -0.289737369453023 0.769655185893943 0.305574789459078 0.688979545697046 PITA;miRanda;miRNATAP -0.136315081074781 0.000219626951219304 NA NA NA hsa-miR-15b-5p LATS1 0.251826642099145 0.790709218602499 -0.160115311260593 0.655519528966827 MirTarget;miRNATAP -0.121534685682813 0.00524690163098967 NA NA NA hsa-miR-107 LATS2 -0.289737369453023 0.769655185893943 0.121471542984644 0.778399929406237 PITA;miRanda;miRNATAP -0.103859864107493 0.0374228856943613 NA NA NA hsa-miR-27a-3p LBR 0.309634509674364 0.703724209648479 -0.259616935759679 0.587874017830765 miRNAWalker2_validate;MirTarget -0.152876515746015 0.000424379462795386 NA NA NA hsa-miR-98-5p LBR -0.0484028619275874 0.910781316485549 -0.259616935759679 0.587874017830765 MirTarget -0.135455952064989 3.56638653691643e-05 NA NA NA hsa-miR-197-3p LDHB 0.0240027695773914 0.981971058073739 0.035100553022934 0.960891001486546 miRNAWalker2_validate -0.156393248539817 0.0167022476720956 NA NA NA hsa-miR-221-3p LDHB -0.261179092929062 0.744019631321393 0.035100553022934 0.960891001486546 miRNAWalker2_validate -0.24881689500269 2.1334844314979e-07 NA NA NA hsa-miR-107 LDOC1L -0.289737369453023 0.769655185893943 0.0732429660355871 0.884216732301365 mirMAP -0.14600726677637 0.000293852477919896 NA NA NA hsa-miR-22-3p LEMD3 0.0468440219945929 0.967778504781139 0.222015168643809 0.612892589332979 miRNAWalker2_validate -0.105393272709764 1.3457383311654e-05 NA NA NA hsa-miR-27a-3p LENG1 0.309634509674364 0.703724209648479 0.037327368713973 0.899758730371754 miRNAWalker2_validate -0.115824843555249 0.00169847528049327 NA NA NA hsa-miR-197-3p LENG8 0.0240027695773914 0.981971058073739 -0.485021398564162 0.477316074769018 mirMAP -0.203792768793761 0.00307543837918475 NA NA NA hsa-miR-107 LEPR -0.289737369453023 0.769655185893943 0.309525993793621 0.426130331480391 miRanda -0.171137668812534 0.0253252419442746 NA NA NA hsa-miR-107 LEPROT -0.289737369453023 0.769655185893943 0.20649264862217 0.678697769568371 miRanda -0.110894562512417 0.0175410376200465 NA NA NA hsa-miR-128-3p LGALS3 -0.0364518492233463 0.95841670253784 0.0599871452596457 0.931418711140413 MirTarget -0.293292196138881 0.000117192101153153 NA NA NA hsa-miR-150-5p LGSN -0.00683324482969283 0.994067057151257 0.949589630372217 0.240689387780884 mirMAP -0.50091778029195 8.14760855681538e-06 NA NA NA hsa-miR-197-3p LGSN 0.0240027695773914 0.981971058073739 0.949589630372217 0.240689387780884 MirTarget -0.585882794017705 0.0197414764286201 NA NA NA hsa-miR-214-3p LGSN 0.0312810611346688 0.952640488671912 0.949589630372217 0.240689387780884 MirTarget -0.466559234842506 0.000264367876171055 NA NA NA hsa-miR-107 LHFP -0.289737369453023 0.769655185893943 0.308864185492454 0.44929087901791 miRanda -0.204426166543221 0.00348683189629679 NA NA NA hsa-miR-139-5p LIAS -0.0625698939687087 0.914810329989088 0.185080367480859 0.543929506859105 miRanda -0.101662522930173 0.00912513083030352 NA NA NA hsa-miR-27a-3p LIFR 0.309634509674364 0.703724209648479 -0.15703128806339 0.75118949901895 miRNAWalker2_validate;MirTarget;miRNATAP -0.108578408120616 0.0498445559654987 NA NA NA hsa-miR-139-5p LIG3 -0.0625698939687087 0.914810329989088 -0.137909619388092 0.755487948338071 miRanda -0.111059978218129 0.00129492511966437 NA NA NA hsa-miR-22-3p LIG3 0.0468440219945929 0.967778504781139 -0.137909619388092 0.755487948338071 MirTarget -0.121992596997723 0.000162584482523215 NA NA NA hsa-miR-98-5p LIN28B -0.0484028619275874 0.910781316485549 -0.521391861717817 0.579651265320971 MirTarget -0.843434153375698 1.79709121848633e-06 NA NA NA hsa-miR-27a-3p LIPT2 0.309634509674364 0.703724209648479 -0.22404916138226 0.426973642842975 MirTarget -0.154147709314646 0.00151150434808498 NA NA NA hsa-miR-148a-3p LIX1 -0.324144803192141 0.746264759480212 1.38152908666231 0.0646060302954672 MirTarget -0.48211593820723 0.00394351069773521 NA NA NA hsa-miR-107 LMOD1 -0.289737369453023 0.769655185893943 0.660625205138824 0.112694741093249 miRanda -0.309563411891037 0.000494511464011501 NA NA NA hsa-miR-148a-3p LMX1B -0.324144803192141 0.746264759480212 -0.439282352711533 0.585599796955181 mirMAP -0.584363009929561 0.00189162997934254 NA NA NA hsa-miR-140-3p LONRF2 -0.105651799466207 0.9077781740714 0.17518072549086 0.758512937812653 mirMAP -0.236821550935239 0.0209528148400399 NA NA NA hsa-miR-27a-3p LPCAT1 0.309634509674364 0.703724209648479 -0.167536679372462 0.769159876369179 MirTarget -0.109952095640746 0.0166560438025069 NA NA NA hsa-miR-148a-3p LRFN1 -0.324144803192141 0.746264759480212 -0.0487923247334439 0.910270617742493 miRNATAP -0.143122385118137 0.0450088103037153 NA NA NA hsa-miR-15b-5p LRIG2 0.251826642099145 0.790709218602499 -0.252703166424234 0.46496130499088 MirTarget -0.134076011309992 0.00236004613662151 NA NA NA hsa-miR-107 LRP1 -0.289737369453023 0.769655185893943 0.145529955861141 0.84586158427387 PITA;miRNATAP -0.154767250159791 0.0276003095042737 NA NA NA hsa-miR-15b-5p LRP6 0.251826642099145 0.790709218602499 -0.211448656253908 0.688300324114048 miRNATAP -0.147721783700826 0.0115172995153562 NA NA NA hsa-miR-221-3p LRP6 -0.261179092929062 0.744019631321393 -0.211448656253908 0.688300324114048 miRNAWalker2_validate -0.11974094819176 0.00696878773980775 NA NA NA hsa-miR-140-3p LRPAP1 -0.105651799466207 0.9077781740714 0.194198051930249 0.754949166141088 mirMAP -0.1627835593999 0.000119519422667773 NA NA NA hsa-miR-107 LRRC17 -0.289737369453023 0.769655185893943 0.932744754460012 0.0158534005392589 miRanda -0.254924783641566 0.0123886847511688 NA NA NA hsa-miR-98-5p LRRC17 -0.0484028619275874 0.910781316485549 0.932744754460012 0.0158534005392589 MirTarget -0.157674562090061 0.0194825738421652 NA NA NA hsa-miR-197-3p LRRC27 0.0240027695773914 0.981971058073739 0.188962400586679 0.555990039328186 mirMAP -0.11879149114725 0.0119543989577703 NA NA NA hsa-miR-150-5p LRRC4 -0.00683324482969283 0.994067057151257 -0.162742709557659 0.710114957656744 miRNATAP -0.149346970927594 0.00153176138488805 NA NA NA hsa-miR-107 LRRK2 -0.289737369453023 0.769655185893943 0.0926174645890453 0.793802976019387 miRanda -0.244479966059499 0.015247332963176 NA NA NA hsa-miR-128-3p LRRN4CL -0.0364518492233463 0.95841670253784 0.521704293216385 0.141650024323726 MirTarget -0.428550579514194 1.86890384285846e-05 NA NA NA hsa-miR-107 LTBP2 -0.289737369453023 0.769655185893943 0.181061839639702 0.795920603027057 miRanda -0.179367118687258 0.0179795060841582 NA NA NA hsa-miR-148a-3p LYNX1 -0.324144803192141 0.746264759480212 -0.620204138635312 0.323199147587821 mirMAP -0.306408111408694 0.0122505118885525 NA NA NA hsa-miR-15b-5p LYPLA2 0.251826642099145 0.790709218602499 0.0466380521271166 0.933883858584386 miRNATAP -0.11919574403544 0.0066780418804974 NA NA NA hsa-miR-221-3p LYSMD1 -0.261179092929062 0.744019631321393 0.0459177665208772 0.905657122423434 miRNAWalker2_validate -0.189150766146668 6.87065120620259e-10 NA NA NA hsa-miR-363-3p MACC1 -0.186046567396088 0.728622856049059 0.260220928613358 0.652024072027222 mirMAP -0.205241069490029 0.000258209358002278 NA NA NA hsa-miR-148a-3p MAF1 -0.324144803192141 0.746264759480212 0.103224605469632 0.883532262252436 MirTarget;miRNATAP -0.102425630268453 0.00601704673884222 NA NA NA hsa-miR-139-5p MAGEF1 -0.0625698939687087 0.914810329989088 -0.0119118806789968 0.982790817036665 miRanda -0.105487167552931 0.00256995859798472 NA NA NA hsa-miR-22-3p MAGI2 0.0468440219945929 0.967778504781139 -0.00790751687369751 0.980258124097068 MirTarget -0.14276229279922 0.00116937953752452 NA NA NA hsa-miR-107 MAMSTR -0.289737369453023 0.769655185893943 0.332155827435769 0.408542067111864 miRNATAP -0.337006366289374 0.000154244666438632 NA NA NA hsa-miR-15b-5p MAMSTR 0.251826642099145 0.790709218602499 0.332155827435769 0.408542067111864 MirTarget;miRNATAP -0.202307254292015 0.0294693578130639 NA NA NA hsa-miR-107 MAN1A1 -0.289737369453023 0.769655185893943 0.22194050554855 0.658159205811332 miRanda -0.222913335870863 0.0192902062689581 NA NA NA hsa-miR-27a-3p MANEAL 0.309634509674364 0.703724209648479 0.149925274189369 0.733611157474911 miRNATAP -0.35870596048083 1.08050486043473e-05 NA NA NA hsa-miR-22-3p MAOA 0.0468440219945929 0.967778504781139 0.216267758614028 0.608331488431146 miRNAWalker2_validate;miRTarBase -0.160485811449646 0.026734024832982 NA NA NA hsa-miR-222-3p MAP3K10 -0.233673471709747 0.726651775432807 -0.291204049416834 0.452237345842688 MirTarget;miRNATAP -0.106867913997144 0.0169617473011264 NA NA NA hsa-miR-98-5p MAP4K4 -0.0484028619275874 0.910781316485549 -0.0311215233337272 0.957041209829705 MirTarget -0.127281230301707 2.4953225605467e-05 NA NA NA hsa-miR-221-3p MAPK10 -0.261179092929062 0.744019631321393 0.523870197809813 0.235148628130106 miRNATAP -0.393525241288137 8.94266232587406e-05 NA NA NA hsa-miR-222-3p MAPK10 -0.233673471709747 0.726651775432807 0.523870197809813 0.235148628130106 miRNATAP -0.373438856768302 0.000182016627023444 NA NA NA hsa-miR-107 MAPRE2 -0.289737369453023 0.769655185893943 0.0919708322527146 0.82595480910976 miRanda -0.120042625634459 0.0121849151522671 NA NA NA hsa-miR-27a-3p MAPT 0.309634509674364 0.703724209648479 0.0350134460924524 0.92874988474302 miRNATAP -0.245482615237444 0.0132295882816802 NA NA NA hsa-miR-222-3p MARS -0.233673471709747 0.726651775432807 -0.148404703023964 0.801134615792965 miRNAWalker2_validate -0.112568624035877 4.37599241036931e-05 NA NA NA hsa-miR-140-3p MARVELD2 -0.105651799466207 0.9077781740714 -0.144681662924778 0.696407165274861 miRNATAP -0.137938899646056 0.00491457511068791 NA NA NA hsa-miR-15b-5p MASP1 0.251826642099145 0.790709218602499 -0.909621259614214 0.0597362156882121 MirTarget -0.527685974429099 0.000262913248327023 NA NA NA hsa-miR-381-3p MAT2B 0.269633663970002 0.562625029053898 0.118747206326431 0.840236308314421 MirTarget -0.130818855838947 1.96607030437342e-06 NA NA NA hsa-miR-107 MBNL2 -0.289737369453023 0.769655185893943 0.328924240652993 0.560738790022646 miRanda;miRNATAP -0.158873149146417 0.000329364629550666 NA NA NA hsa-miR-15b-5p MBNL2 0.251826642099145 0.790709218602499 0.328924240652993 0.560738790022646 MirTarget -0.146472514499701 0.00141344651961067 NA NA NA hsa-miR-150-5p MCF2L -0.00683324482969283 0.994067057151257 -0.278288322912854 0.528025134614079 mirMAP -0.114276385624372 0.00907908934944747 NA NA NA hsa-miR-222-3p MCM3 -0.233673471709747 0.726651775432807 -0.325905981227457 0.583969057337992 miRNAWalker2_validate -0.102939232578558 0.00539214960164398 NA NA NA hsa-miR-222-3p MCM7 -0.233673471709747 0.726651775432807 -0.21704844343859 0.731614992624178 miRNAWalker2_validate -0.128923317932551 0.000345244045848528 NA NA NA hsa-miR-98-5p MDFI -0.0484028619275874 0.910781316485549 0.0864656344520851 0.871837354414125 MirTarget -0.224402855526144 0.00623505600009333 NA NA NA hsa-miR-148a-3p MDGA2 -0.324144803192141 0.746264759480212 -0.643726142335592 0.27054027920652 miRNATAP -0.245901763109445 0.0406840196685085 NA NA NA hsa-miR-22-3p MECOM 0.0468440219945929 0.967778504781139 0.104531166144888 0.866398503213567 miRNATAP -0.175139796434344 0.0019815004335689 NA NA NA hsa-miR-107 MECP2 -0.289737369453023 0.769655185893943 -0.26581565012751 0.64682167391541 mirMAP -0.102339996690988 0.00812726681711117 NA NA NA hsa-miR-107 MEGF8 -0.289737369453023 0.769655185893943 -0.262187012335394 0.645341783030519 miRanda -0.16008418491317 0.0134396672758809 NA NA NA hsa-miR-139-5p MEIS1 -0.0625698939687087 0.914810329989088 0.245909423215222 0.713447142638256 miRanda -0.131076054091319 0.005693663016557 NA NA NA hsa-miR-107 MEOX2 -0.289737369453023 0.769655185893943 2.32321245960112 0.000545275488870563 miRanda -0.548449291336062 0.00518470491320469 NA NA NA hsa-miR-107 MEST -0.289737369453023 0.769655185893943 0.0589598360878076 0.930112474194024 miRanda -0.180120451042304 0.0353599762587732 NA NA NA hsa-miR-107 METTL9 -0.289737369453023 0.769655185893943 0.143827503135352 0.811836337139752 miRanda -0.105008473320978 0.00467856757228112 NA NA NA hsa-miR-150-5p MEX3A -0.00683324482969283 0.994067057151257 -0.515964067558559 0.36569876644874 MirTarget -0.157252282511819 9.77907483803316e-05 NA NA NA hsa-miR-221-3p MEX3A -0.261179092929062 0.744019631321393 -0.515964067558559 0.36569876644874 MirTarget -0.397247161082086 1.30055715019131e-09 NA NA NA hsa-miR-222-3p MEX3A -0.233673471709747 0.726651775432807 -0.515964067558559 0.36569876644874 MirTarget -0.41379636443817 1.63787256383105e-10 NA NA NA hsa-miR-15b-5p MEX3B 0.251826642099145 0.790709218602499 0.0580753246251327 0.853583579699043 mirMAP -0.163562559464641 0.0472183624507341 NA NA NA hsa-miR-98-5p MGAT3 -0.0484028619275874 0.910781316485549 -0.391474485907282 0.46172217806179 mirMAP -0.162370724718604 0.017632778879122 NA NA NA hsa-miR-15b-5p MIB1 0.251826642099145 0.790709218602499 0.0258197040377963 0.955757277760357 miRNATAP -0.139386057807101 0.0015603320502765 NA NA NA hsa-miR-15b-5p MIPOL1 0.251826642099145 0.790709218602499 -0.0846346501667381 0.770324570800397 MirTarget -0.202206594050164 0.00928082058260099 NA NA NA hsa-miR-15b-5p MLXIP 0.251826642099145 0.790709218602499 -0.162080780703973 0.772024529124195 mirMAP -0.143171099360687 0.00316467646727878 NA NA NA hsa-miR-15b-5p MLYCD 0.251826642099145 0.790709218602499 0.0845276471539211 0.803177508059747 MirTarget -0.156905645954771 0.000137923507197141 NA NA NA hsa-miR-148a-3p MMD -0.324144803192141 0.746264759480212 0.240412246237321 0.579766828845087 miRNATAP -0.1144640846148 0.0498720966174475 NA NA NA hsa-miR-107 MMP16 -0.289737369453023 0.769655185893943 -0.379593897846034 0.297169015601653 PITA;miRanda;mirMAP -0.277773755159364 0.00779186874863781 NA NA NA hsa-miR-107 MN1 -0.289737369453023 0.769655185893943 0.293503133520217 0.535647308694591 miRanda;miRNATAP -0.329196095740197 0.0045121643573116 NA NA NA hsa-miR-107 MPND -0.289737369453023 0.769655185893943 0.101383537902284 0.787962047512557 miRanda -0.12293555208611 0.00869282811081548 NA NA NA hsa-miR-140-3p MRPL15 -0.105651799466207 0.9077781740714 0.13002151339712 0.82119768731574 MirTarget -0.14905095601708 0.000300258197309338 NA NA NA hsa-miR-197-3p MRPS21 0.0240027695773914 0.981971058073739 0.0492755104704878 0.933208833721286 MirTarget -0.159526489926726 0.00808585886689627 NA NA NA hsa-miR-128-3p MSRB3 -0.0364518492233463 0.95841670253784 0.651527293321505 0.134047439300427 MirTarget -0.232441151370909 0.00461796557095952 NA NA NA hsa-miR-107 MT1E -0.289737369453023 0.769655185893943 1.09495589125117 0.0879787099760846 miRanda -0.276627471048425 0.0437754797024939 NA NA NA hsa-miR-148a-3p MTMR9 -0.324144803192141 0.746264759480212 0.0188644934148083 0.953918308047657 miRNAWalker2_validate;MirTarget -0.104257798483369 0.00153348502800583 NA NA NA hsa-miR-15b-5p MTSS1 0.251826642099145 0.790709218602499 -0.0101321724379071 0.982409900942986 miRNATAP -0.256757587402273 0.000217307915332821 25783158;26743779 EGF induces microRNAs that target suppressors of cell migration: miR 15b targets MTSS1 in breast cancer; One of these miRNAs miR-15b targeted the 3' untranslated region of MTSS1 metastasis suppressor protein 1;High plasma miR-15b level and negative MTSS1 and Klotho expression in tumor tissues significantly correlated with poor survival; Inhibition of miR-15b activity by adenovirus carrying antimiR-15b sequence significantly increased MTSS1 and Klotho protein expression and subsequently decreased colony formation ability invasion and migration of HCT116 cells in vitro and liver metastasis of HCT116 tumors in vivo; In conclusion high abundance of circulating miR-15b correlated with tumor metastasis recurrence and poor patient prognosis through downregulation of MTSS1 and Klotho protein expression cell migration;metastasis;poor survival;metastasis;worse prognosis;recurrence breast cancer;colorectal cancer hsa-miR-128-3p MTSS1L -0.0364518492233463 0.95841670253784 -0.0538657103528779 0.920893759611299 MirTarget -0.10745761403911 0.0391839534897681 NA NA NA hsa-miR-107 MTUS1 -0.289737369453023 0.769655185893943 -0.00332238502862037 0.994561166135737 miRanda -0.117201541177076 0.0432698818109558 NA NA NA hsa-miR-107 MTUS2 -0.289737369453023 0.769655185893943 -0.380919764393437 0.339334726153731 miRanda;miRNATAP -0.447483789531952 0.000107913350047151 NA NA NA hsa-miR-107 MUM1L1 -0.289737369453023 0.769655185893943 0.0376543855064972 0.932627248899127 miRanda -0.274901222640474 0.0323231181172877 NA NA NA hsa-miR-148a-3p MUM1L1 -0.324144803192141 0.746264759480212 0.0376543855064972 0.932627248899127 MirTarget;miRNATAP -0.215594207390676 0.0345412736874207 NA NA NA hsa-miR-150-5p MUM1L1 -0.00683324482969283 0.994067057151257 0.0376543855064972 0.932627248899127 MirTarget -0.188036112994308 0.00199530068779277 NA NA NA hsa-miR-107 MXD4 -0.289737369453023 0.769655185893943 0.262063113999464 0.665352638416925 miRanda;miRNATAP -0.124350754011406 0.00594152243732408 NA NA NA hsa-miR-148a-3p MXRA7 -0.324144803192141 0.746264759480212 -0.0379244672390282 0.954076955491962 mirMAP -0.100799423251459 0.0275033713329146 NA NA NA hsa-miR-127-3p MYB 0.231539840651733 0.822108193638849 0.0332473030591585 0.938223116248872 miRanda -0.162171895479518 0.00537056619626271 NA NA NA hsa-miR-139-5p MYB -0.0625698939687087 0.914810329989088 0.0332473030591585 0.938223116248872 miRanda -0.23718899017367 0.00255084046020176 NA NA NA hsa-miR-107 MYCN -0.289737369453023 0.769655185893943 0.228799689543911 0.667541591931963 miRanda -0.323128197424988 0.0137300141812264 NA NA NA hsa-miR-107 MYH11 -0.289737369453023 0.769655185893943 0.296909635940923 0.58051536799149 miRanda -0.323257678549824 0.0120087324748217 NA NA NA hsa-miR-107 MYL12B -0.289737369453023 0.769655185893943 0.411398842328717 0.563308075820262 miRanda -0.14781949369509 0.000924054591083789 NA NA NA hsa-miR-221-3p MYLIP -0.261179092929062 0.744019631321393 -0.182670852365389 0.725986214497763 MirTarget -0.100230553812015 0.00600353592968708 NA NA NA hsa-miR-27a-3p MYOCD 0.309634509674364 0.703724209648479 -0.711731299560881 0.210427017883159 miRNATAP -0.291538595958444 0.0470639056622417 NA NA NA hsa-miR-15b-5p MYRIP 0.251826642099145 0.790709218602499 -0.125991294654411 0.73886321574633 MirTarget -0.200223582618296 0.0421017696712115 NA NA NA hsa-miR-15b-5p N4BP1 0.251826642099145 0.790709218602499 -0.0959021532881064 0.857312114620154 miRNATAP -0.127979336902623 0.000244198632447609 NA NA NA hsa-miR-139-5p NAB2 -0.0625698939687087 0.914810329989088 -0.027108228126969 0.960319717501685 miRanda -0.129681312592998 0.000272215054826419 NA NA NA hsa-miR-660-5p NAP1L1 -0.561687438133488 0.138270972367544 0.376236804150212 0.610074183141145 MirTarget -0.117207501093516 6.15505491700052e-05 NA NA NA hsa-miR-128-3p NAP1L5 -0.0364518492233463 0.95841670253784 -0.0158416839941031 0.959606844813121 MirTarget -0.237219820129276 0.0040816651572671 NA NA NA hsa-miR-221-3p NAP1L5 -0.261179092929062 0.744019631321393 -0.0158416839941031 0.959606844813121 MirTarget;miRNATAP -0.127589537406286 0.0412340988263608 NA NA NA hsa-miR-197-3p NAPB 0.0240027695773914 0.981971058073739 -0.276799113439572 0.405987709254828 MirTarget -0.113486178564269 0.0143560749193208 NA NA NA hsa-miR-107 NAT14 -0.289737369453023 0.769655185893943 0.133418714326888 0.736110047821657 miRanda -0.28648497118462 6.04631269335041e-06 NA NA NA hsa-miR-148a-3p NAT14 -0.324144803192141 0.746264759480212 0.133418714326888 0.736110047821657 miRNATAP -0.135526059492213 0.00770486426269508 NA NA NA hsa-miR-107 NAT8L -0.289737369453023 0.769655185893943 -0.194610295745648 0.666510166719488 miRNATAP -0.198503709477065 0.0402027762452078 NA NA NA hsa-miR-140-3p NAT8L -0.105651799466207 0.9077781740714 -0.194610295745648 0.666510166719488 mirMAP -0.250360681343493 0.00472819942872071 NA NA NA hsa-miR-148a-3p NAT8L -0.324144803192141 0.746264759480212 -0.194610295745648 0.666510166719488 MirTarget -0.200584522524769 0.0088782220378639 NA NA NA hsa-miR-150-5p NAT8L -0.00683324482969283 0.994067057151257 -0.194610295745648 0.666510166719488 mirMAP -0.101374672805646 0.0275369092725084 NA NA NA hsa-miR-15b-5p NAT8L 0.251826642099145 0.790709218602499 -0.194610295745648 0.666510166719488 miRNATAP -0.318213492884822 0.00139946838933378 NA NA NA hsa-miR-214-3p NAT8L 0.0312810611346688 0.952640488671912 -0.194610295745648 0.666510166719488 MirTarget -0.118976874063757 0.0223545138034632 NA NA NA hsa-miR-660-5p NAT8L -0.561687438133488 0.138270972367544 -0.194610295745648 0.666510166719488 mirMAP -0.191083566424381 0.00152859258219449 NA NA NA hsa-miR-128-3p NBEA -0.0364518492233463 0.95841670253784 -0.275712959870817 0.486362021902307 miRNAWalker2_validate -0.32813053772347 0.00526933358719167 NA NA NA hsa-miR-107 NBL1 -0.289737369453023 0.769655185893943 0.769799522387103 0.250444811249258 miRanda -0.344177987490751 9.1993885509739e-05 NA NA NA hsa-miR-222-3p NBPF3 -0.233673471709747 0.726651775432807 -0.276552256583735 0.394278443047512 MirTarget -0.100180671410591 0.0483671415927705 NA NA NA hsa-miR-222-3p NCAPD2 -0.233673471709747 0.726651775432807 -0.237057164680508 0.716551982661152 miRNAWalker2_validate -0.147428798550067 0.000313873086953471 NA NA NA hsa-miR-107 NDFIP1 -0.289737369453023 0.769655185893943 0.218779692578825 0.74284234166211 miRanda -0.111059271922476 0.000423167071325736 NA NA NA hsa-miR-660-5p NDST3 -0.561687438133488 0.138270972367544 -0.427897090227842 0.413882939364864 MirTarget -0.251860080733569 0.0102072387435228 NA NA NA hsa-miR-214-3p NDUFAF4 0.0312810611346688 0.952640488671912 0.114161597306842 0.783131150977471 MirTarget -0.108965324834893 4.09226347610003e-05 NA NA NA hsa-miR-363-3p NEBL -0.186046567396088 0.728622856049059 0.240365534867492 0.629156990841571 mirMAP -0.138509681939428 0.0103303178612246 NA NA NA hsa-miR-107 NEDD9 -0.289737369453023 0.769655185893943 0.450954311170567 0.422436334094576 MirTarget;PITA;miRanda;miRNATAP -0.182565099436603 0.046078683996587 NA NA NA hsa-miR-98-5p NEK3 -0.0484028619275874 0.910781316485549 0.0355624330436375 0.902150967315788 miRNAWalker2_validate -0.153002795012835 3.64030629174472e-05 NA NA NA hsa-miR-15b-5p NFAT5 0.251826642099145 0.790709218602499 -0.0451008314815349 0.932558744469138 MirTarget -0.11832723278323 0.0212678314753098 NA NA NA hsa-miR-221-3p NFATC3 -0.261179092929062 0.744019631321393 -0.0467493749243486 0.918936458770211 MirTarget;miRNATAP -0.129625119146625 3.64656939307274e-05 NA NA NA hsa-miR-222-3p NFATC3 -0.233673471709747 0.726651775432807 -0.0467493749243486 0.918936458770211 MirTarget;miRNATAP -0.120080195297181 0.000119274873908316 NA NA NA hsa-miR-27a-3p NFIA 0.309634509674364 0.703724209648479 0.203437541070212 0.72842105764397 mirMAP;miRNATAP -0.115730916164154 0.0241026346003565 NA NA NA hsa-miR-107 NFIL3 -0.289737369453023 0.769655185893943 -0.039332104030386 0.928285049079243 miRanda -0.10408436090478 0.0251269051472641 NA NA NA hsa-miR-221-3p NFYA -0.261179092929062 0.744019631321393 -0.148815180274824 0.758816376090414 miRNAWalker2_validate -0.105290167893947 0.000653754005949671 NA NA NA hsa-miR-98-5p NGF -0.0484028619275874 0.910781316485549 0.0606947374867796 0.868848915772776 MirTarget -0.193090544409303 0.00656225416048939 NA NA NA hsa-miR-27a-3p NGFR 0.309634509674364 0.703724209648479 0.0808558734911828 0.87477900264211 miRNATAP -0.441499463546649 0.000582451228597517 NA NA NA hsa-miR-22-3p NHP2 0.0468440219945929 0.967778504781139 0.277553057333573 0.637211429118291 MirTarget -0.158469560721771 1.27373153233441e-05 NA NA NA hsa-miR-221-3p NHSL1 -0.261179092929062 0.744019631321393 -0.0218678157528194 0.957716277431275 miRNAWalker2_validate -0.110512002090797 0.0449916458235144 NA NA NA hsa-miR-107 NINJ1 -0.289737369453023 0.769655185893943 -0.201825946897513 0.71890145375678 miRNAWalker2_validate -0.121676045064141 0.00756263516102128 NA NA NA hsa-miR-15b-5p NISCH 0.251826642099145 0.790709218602499 -0.237663017300441 0.695375907186771 MirTarget -0.178322846983083 6.63893485193274e-05 NA NA NA hsa-miR-221-3p NLE1 -0.261179092929062 0.744019631321393 -0.0728060386186562 0.839273445612345 mirMAP -0.110295404172446 0.00148296343858819 NA NA NA hsa-miR-107 NLGN1 -0.289737369453023 0.769655185893943 -0.729553026296322 0.169812125294617 PITA;miRanda -0.328237375934883 0.0387444650251745 NA NA NA hsa-miR-221-3p NLK -0.261179092929062 0.744019631321393 -0.0636934459576137 0.869819748947338 MirTarget;miRNATAP -0.111554625598997 0.000232292135467114 NA NA NA hsa-miR-222-3p NLK -0.233673471709747 0.726651775432807 -0.0636934459576137 0.869819748947338 MirTarget;miRNATAP -0.143042927111369 1.6176286197191e-06 NA NA NA hsa-miR-27a-3p NMB 0.309634509674364 0.703724209648479 0.0428632842606596 0.905103585100286 MirTarget -0.128945113023678 0.0389093128118002 NA NA NA hsa-miR-197-3p NME2 0.0240027695773914 0.981971058073739 0.274812496001704 0.715911319862544 miRNAWalker2_validate -0.110706053662734 0.0381142018704608 NA NA NA hsa-miR-107 NME4 -0.289737369453023 0.769655185893943 0.248239189776092 0.66157357272234 miRanda -0.15618030110751 0.00345759985129285 NA NA NA hsa-miR-98-5p NME4 -0.0484028619275874 0.910781316485549 0.248239189776092 0.66157357272234 MirTarget -0.121391124865176 0.000572327671159482 NA NA NA hsa-miR-15b-5p NOB1 0.251826642099145 0.790709218602499 0.162540587218787 0.756736939793649 MirTarget -0.18143681424207 7.44398917356847e-05 NA NA NA hsa-miR-148a-3p NOG -0.324144803192141 0.746264759480212 1.1420266546623 0.0138928936282003 MirTarget;miRNATAP -0.290759916931689 0.00816771396122413 NA NA NA hsa-miR-27a-3p NOL4 0.309634509674364 0.703724209648479 -0.204306724760897 0.765361582972055 miRNATAP -0.365517749092226 0.00943716427879655 NA NA NA hsa-miR-107 NOS1 -0.289737369453023 0.769655185893943 -0.80405302170729 0.226452743510243 miRNATAP -0.478593745268794 0.0129445440557645 NA NA NA hsa-miR-221-3p NOVA1 -0.261179092929062 0.744019631321393 0.114222288412774 0.808366255333672 miRNATAP -0.407431251678011 0.000140789994580519 NA NA NA hsa-miR-222-3p NOVA1 -0.233673471709747 0.726651775432807 0.114222288412774 0.808366255333672 miRNATAP -0.441936005892396 3.01591364560783e-05 NA NA NA hsa-miR-27a-3p NOVA1 0.309634509674364 0.703724209648479 0.114222288412774 0.808366255333672 miRNATAP -0.373882685080197 0.00171907878407069 NA NA NA hsa-miR-107 NPAS2 -0.289737369453023 0.769655185893943 0.341541264882074 0.553127312805121 miRanda;miRNATAP -0.307539551488061 0.00296004436360406 NA NA NA hsa-miR-107 NPY1R -0.289737369453023 0.769655185893943 0.020202143431716 0.971189484353485 miRanda -0.482795955465455 0.00332939886462063 NA NA NA hsa-miR-197-3p NR2C2 0.0240027695773914 0.981971058073739 -0.26369044756531 0.612938320469627 MirTarget -0.149553384658997 0.000342577449294786 NA NA NA hsa-miR-148a-3p NRARP -0.324144803192141 0.746264759480212 -0.177230104045369 0.690572948752183 MirTarget -0.113750790971509 0.021087760932137 NA NA NA hsa-miR-27a-3p NRARP 0.309634509674364 0.703724209648479 -0.177230104045369 0.690572948752183 MirTarget -0.158446897840824 0.00336131041843081 NA NA NA hsa-miR-98-5p NRARP -0.0484028619275874 0.910781316485549 -0.177230104045369 0.690572948752183 MirTarget -0.123206615749009 0.0026318240974553 NA NA NA hsa-miR-214-3p NRG4 0.0312810611346688 0.952640488671912 -0.0658483498830873 0.899494179878125 MirTarget -0.273074550211517 0.00106382908335362 NA NA NA hsa-miR-107 NRP2 -0.289737369453023 0.769655185893943 0.141402624157643 0.822387762668146 PITA;miRanda;miRNATAP -0.215004577030632 0.0236808730312418 NA NA NA hsa-miR-221-3p NSMCE4A -0.261179092929062 0.744019631321393 0.172981314666597 0.69491576255198 MirTarget -0.117998815923071 0.000135183669174312 NA NA NA hsa-miR-222-3p NSMCE4A -0.233673471709747 0.726651775432807 0.172981314666597 0.69491576255198 MirTarget -0.100255324095749 0.00112429688424157 NA NA NA hsa-miR-221-3p NT5DC2 -0.261179092929062 0.744019631321393 0.141424580891696 0.822040479986213 miRNAWalker2_validate -0.147468099501814 0.000818869648245789 NA NA NA hsa-miR-221-3p NTF3 -0.261179092929062 0.744019631321393 0.858728450070405 0.127020238221505 miRNATAP -0.309507169396291 0.0197614931510882 NA NA NA hsa-miR-222-3p NTF3 -0.233673471709747 0.726651775432807 0.858728450070405 0.127020238221505 miRNATAP -0.282887842785759 0.0318975394699351 NA NA NA hsa-miR-107 NTRK2 -0.289737369453023 0.769655185893943 0.132288227177412 0.755349144822091 PITA;miRanda -0.409395396926516 0.00030514186575642 NA NA NA hsa-miR-128-3p NTRK3 -0.0364518492233463 0.95841670253784 0.0833565341477112 0.900425585327201 miRNAWalker2_validate;miRTarBase -0.447381840542153 0.0297609938373558 NA NA NA hsa-miR-660-5p NTRK3 -0.561687438133488 0.138270972367544 0.0833565341477112 0.900425585327201 mirMAP -0.2467273088696 0.0462120296208033 NA NA NA hsa-miR-98-5p NTRK3 -0.0484028619275874 0.910781316485549 0.0833565341477112 0.900425585327201 mirMAP -0.428318523602906 0.000983169874204467 NA NA NA hsa-miR-107 NUDT11 -0.289737369453023 0.769655185893943 0.134265353309455 0.723884102669589 miRanda -0.335956532186566 0.00283286245590525 NA NA NA hsa-miR-22-3p NUDT4 0.0468440219945929 0.967778504781139 0.306947231961959 0.516273454611005 MirTarget;miRNATAP -0.147501991692451 0.00125398914911248 NA NA NA hsa-miR-221-3p NUF2 -0.261179092929062 0.744019631321393 0.0736115796363661 0.853426514695281 miRNAWalker2_validate -0.193520958235536 0.000248756283895222 NA NA NA hsa-miR-660-5p NUFIP1 -0.561687438133488 0.138270972367544 0.280463392837723 0.385469934405503 MirTarget -0.103968921435712 3.7725058735408e-05 NA NA NA hsa-miR-139-5p NUP210 -0.0625698939687087 0.914810329989088 -0.314809898951629 0.613838467162813 miRanda -0.105600878225134 0.031675865543565 NA NA NA hsa-miR-140-3p NXN -0.105651799466207 0.9077781740714 -0.271724906317887 0.663502292719552 PITA;miRNATAP -0.132234457848233 0.0233573709202194 NA NA NA hsa-miR-140-3p OCLN -0.105651799466207 0.9077781740714 -0.217929537829503 0.616601731262907 mirMAP -0.172702570737185 0.000267515648414945 NA NA NA hsa-miR-140-3p OLA1 -0.105651799466207 0.9077781740714 -0.188608643524996 0.752947981569764 miRNATAP -0.180686270082275 6.29720829508017e-07 NA NA NA hsa-miR-221-3p OLA1 -0.261179092929062 0.744019631321393 -0.188608643524996 0.752947981569764 miRNATAP -0.114949307814663 0.000243025818380475 NA NA NA hsa-miR-222-3p OLA1 -0.233673471709747 0.726651775432807 -0.188608643524996 0.752947981569764 miRNAWalker2_validate -0.1132806471557 0.000268168315116966 NA NA NA hsa-miR-107 OLFM1 -0.289737369453023 0.769655185893943 -0.238801621884931 0.648057743193167 PITA;miRanda;miRNATAP -0.392155277833572 0.00924321662394775 NA NA NA hsa-miR-107 OLFML1 -0.289737369453023 0.769655185893943 0.305858300395963 0.475821100274389 miRanda -0.268451583566613 0.00263230840084081 NA NA NA hsa-miR-27a-3p ONECUT2 0.309634509674364 0.703724209648479 -0.237278021663198 0.6379903055134 miRNATAP -0.29518534469693 0.0252039205612485 NA NA NA hsa-miR-15b-5p OPRL1 0.251826642099145 0.790709218602499 0.296845285588109 0.287638465712838 mirMAP -0.274922236420953 8.49277903984734e-05 NA NA NA hsa-miR-107 OSBPL6 -0.289737369453023 0.769655185893943 -0.357919972365256 0.443939897583447 miRanda;miRNATAP -0.385146931617015 0.00522811138079396 NA NA NA hsa-miR-140-3p OTUB1 -0.105651799466207 0.9077781740714 0.0611181497931943 0.92987679933319 PITA -0.150586877357552 4.64640807127058e-08 NA NA NA hsa-miR-214-3p P4HTM 0.0312810611346688 0.952640488671912 0.0907735401146175 0.867011565546993 MirTarget -0.112311266640433 3.93791641878222e-06 NA NA NA hsa-miR-127-3p PA2G4 0.231539840651733 0.822108193638849 0.295654482705588 0.652943405419874 miRanda -0.107764904315686 1.6494719410002e-07 NA NA NA hsa-miR-107 PAK3 -0.289737369453023 0.769655185893943 0.920809798971622 0.118751874817418 miRanda -0.335381463607498 0.0426204334130676 NA NA NA hsa-miR-150-5p PALM2 -0.00683324482969283 0.994067057151257 0.124267555548599 0.719368375482953 mirMAP -0.12278863385031 0.00551555887835894 NA NA NA hsa-miR-15b-5p PAM 0.251826642099145 0.790709218602499 0.162646958592559 0.80464908790382 miRNATAP -0.326289669887208 1.25014206890719e-05 NA NA NA hsa-miR-214-3p PAN2 0.0312810611346688 0.952640488671912 0.0511795211585202 0.916933529374309 MirTarget -0.138309135307188 4.37919975088873e-07 NA NA NA hsa-miR-222-3p PAN2 -0.233673471709747 0.726651775432807 0.0511795211585202 0.916933529374309 miRNAWalker2_validate -0.13554665231259 0.000726618441974622 NA NA NA hsa-miR-27a-3p PANK1 0.309634509674364 0.703724209648479 -0.0264254428661714 0.945467353578941 miRNATAP -0.180526812338273 0.000432849181994639 NA NA NA hsa-miR-98-5p PAPPA -0.0484028619275874 0.910781316485549 0.470558902758993 0.30496033799475 MirTarget -0.181812904675671 0.0442198279248903 NA NA NA hsa-miR-150-5p PAQR5 -0.00683324482969283 0.994067057151257 -0.388043716682013 0.258658497017939 mirMAP -0.194202445048863 4.11618607888662e-06 NA NA NA hsa-miR-139-5p PATZ1 -0.0625698939687087 0.914810329989088 -0.329534851576771 0.582580486918757 miRanda -0.14229063767326 3.27401776429628e-05 NA NA NA hsa-miR-22-3p PBX1 0.0468440219945929 0.967778504781139 0.164340803932783 0.807580076898079 MirTarget -0.194138411567884 2.28566196281606e-08 NA NA NA hsa-miR-98-5p PBX1 -0.0484028619275874 0.910781316485549 0.164340803932783 0.807580076898079 MirTarget -0.105121723314857 0.000552437820850218 NA NA NA hsa-miR-222-3p PBX2 -0.233673471709747 0.726651775432807 -0.162246585230382 0.793655328714028 miRNAWalker2_validate -0.119122726865663 0.00187876802067484 NA NA NA hsa-miR-363-3p PCDH11X -0.186046567396088 0.728622856049059 -0.146326856854071 0.838908950520701 MirTarget;miRNATAP -0.178347648172711 0.0479559340464927 NA NA NA hsa-miR-107 PCDH9 -0.289737369453023 0.769655185893943 0.194387059486137 0.725495299759085 miRanda -0.345983984696159 0.0341103443392472 NA NA NA hsa-miR-660-5p PCDH9 -0.561687438133488 0.138270972367544 0.194387059486137 0.725495299759085 MirTarget;miRNATAP -0.26870633200103 0.0084675724916667 NA NA NA hsa-miR-15b-5p PCDHA2 0.251826642099145 0.790709218602499 -0.268926547259511 0.598017657087117 MirTarget -0.457622394902518 0.0030586041281686 NA NA NA hsa-miR-221-3p PCDHA2 -0.261179092929062 0.744019631321393 -0.268926547259511 0.598017657087117 MirTarget -0.261523550077618 0.0263532042131098 NA NA NA hsa-miR-222-3p PCDHA2 -0.233673471709747 0.726651775432807 -0.268926547259511 0.598017657087117 MirTarget -0.236886649858966 0.0427440987825123 NA NA NA hsa-miR-15b-5p PCDHA9 0.251826642099145 0.790709218602499 -0.530108257843928 0.379969416014821 MirTarget -0.394065694838313 0.0185648373090242 NA NA NA hsa-miR-107 PCDHGA2 -0.289737369453023 0.769655185893943 0.323921164955682 0.506956459213935 miRanda -0.330190354403211 0.0229980867299139 NA NA NA hsa-miR-107 PCDHGA3 -0.289737369453023 0.769655185893943 -0.109025365539175 0.80287253027672 miRanda -0.302149967622284 0.0192903157009837 NA NA NA hsa-miR-107 PCDHGA4 -0.289737369453023 0.769655185893943 0.335452466790047 0.43685699738015 miRanda -0.354544601126114 0.00545982862754483 NA NA NA hsa-miR-107 PCDHGA5 -0.289737369453023 0.769655185893943 0.472956070159331 0.187314575566294 miRanda -0.307758613087157 0.00363100211905924 NA NA NA hsa-miR-107 PCDHGA6 -0.289737369453023 0.769655185893943 0.0698468874774425 0.843963880667343 miRanda -0.242723341780078 0.0191868581543271 NA NA NA hsa-miR-107 PCDHGA8 -0.289737369453023 0.769655185893943 0.312277651176653 0.486516447666532 miRanda -0.355158827207968 0.00761689569722247 NA NA NA hsa-miR-107 PCDHGA9 -0.289737369453023 0.769655185893943 0.531228523896566 0.248557364492554 miRanda -0.308263402248704 0.0182243870114373 NA NA NA hsa-miR-107 PCDHGB2 -0.289737369453023 0.769655185893943 0.744666497529231 0.103660360344809 miRanda -0.388708554468725 0.00307772018564009 NA NA NA hsa-miR-107 PCDHGB4 -0.289737369453023 0.769655185893943 -0.556666832974654 0.306692126583208 miRanda -0.314627261494649 0.0456336319461438 NA NA NA hsa-miR-107 PCDHGC3 -0.289737369453023 0.769655185893943 0.336485891720545 0.566989158558655 miRanda -0.210912507937492 0.000624724124714964 NA NA NA hsa-miR-15b-5p PDCD4 0.251826642099145 0.790709218602499 0.392198104823223 0.507729728599335 MirTarget;miRNATAP -0.10682597644055 0.036110839368774 NA NA NA hsa-miR-197-3p PDDC1 0.0240027695773914 0.981971058073739 -0.0245974548043471 0.960818976848474 mirMAP -0.24618791043236 8.05107925981514e-08 NA NA NA hsa-miR-107 PDE3B -0.289737369453023 0.769655185893943 -0.41914702311429 0.250716934813876 MirTarget;PITA;miRanda;miRNATAP -0.224336172980914 0.0364552741880176 NA NA NA hsa-miR-128-3p PDE3B -0.0364518492233463 0.95841670253784 -0.41914702311429 0.250716934813876 miRNAWalker2_validate -0.284574541309113 0.0107644571224093 NA NA NA hsa-miR-140-3p PDE6B -0.105651799466207 0.9077781740714 0.375089719552633 0.359696794665873 MirTarget -0.262594547548206 0.00039448780210685 NA NA NA hsa-miR-27a-3p PDE7B 0.309634509674364 0.703724209648479 -0.105448272716949 0.720596351502969 miRNATAP -0.199732643139026 0.00182103126767746 NA NA NA hsa-miR-27a-3p PDE8B 0.309634509674364 0.703724209648479 -0.230216033733265 0.508707091873851 MirTarget -0.245080204171327 0.00626414316303196 NA NA NA hsa-miR-107 PDK4 -0.289737369453023 0.769655185893943 0.690479188061747 0.129784523042214 MirTarget;miRanda;miRNATAP -0.192353364941391 0.0118123523027111 NA NA NA hsa-miR-15b-5p PDK4 0.251826642099145 0.790709218602499 0.690479188061747 0.129784523042214 MirTarget;miRNATAP -0.261743081765223 0.000886923227211238 NA NA NA hsa-miR-15b-5p PDPR 0.251826642099145 0.790709218602499 0.13717349127163 0.793213531362537 miRNATAP -0.152073381723029 0.0119862526786896 NA NA NA hsa-miR-214-3p PDRG1 0.0312810611346688 0.952640488671912 0.250713350071338 0.563737089772658 MirTarget -0.105029389685667 4.49953934460816e-06 25706919 MicroRNA 214 suppresses oncogenesis and exerts impact on prognosis by targeting PDRG1 in bladder cancer; Dual-luciferase reporter assay recognized PDRG1 as direct downstream target gene of miR-214; PDRG1 was significantly increased in tumors low of miR-214 and knockdown of PDRG1 mimicked the effects of miR-214 overexpression; Our findings manifest that miR-214 could exert tumor-suppressive effects in bladder cancer by directly down-regulating oncogene PDRG1 and suggest an appealing novel indicator for prognostic and therapeutic intervention of bladder cancer worse prognosis bladder cancer hsa-miR-107 PDS5B -0.289737369453023 0.769655185893943 -0.0631705270907341 0.886982264368488 miRanda -0.127585807766948 0.000327953768110736 NA NA NA hsa-miR-150-5p PEG10 -0.00683324482969283 0.994067057151257 0.00912550920660937 0.989899679885026 miRNATAP -0.190919832327342 0.00160227621262904 NA NA NA hsa-miR-221-3p PEG10 -0.261179092929062 0.744019631321393 0.00912550920660937 0.989899679885026 miRNAWalker2_validate -0.199199056700491 0.0474630333657355 NA NA NA hsa-miR-15b-5p PEX12 0.251826642099145 0.790709218602499 0.229539682519236 0.421252365014421 MirTarget -0.1688485320692 1.69422482035221e-05 NA NA NA hsa-miR-221-3p PEX19 -0.261179092929062 0.744019631321393 0.177233126323997 0.77412023543468 miRNAWalker2_validate -0.176392489378683 7.39749552158275e-11 NA NA NA hsa-miR-15b-5p PEX5 0.251826642099145 0.790709218602499 -0.0541579382911079 0.912996954225504 MirTarget;miRNATAP -0.146634812835041 0.000615040019278257 NA NA NA hsa-miR-22-3p PEX5 0.0468440219945929 0.967778504781139 -0.0541579382911079 0.912996954225504 miRNAWalker2_validate -0.143455706822147 5.33700341873953e-06 NA NA NA hsa-miR-214-3p PFKFB4 0.0312810611346688 0.952640488671912 -0.515334899367728 0.196408330550881 MirTarget -0.10273071324768 0.00403203895686564 NA NA NA hsa-miR-27a-3p PFKM 0.309634509674364 0.703724209648479 0.246269933062444 0.63558351149718 MirTarget -0.105130399121787 0.0233675137059517 NA NA NA hsa-miR-150-5p PFN2 -0.00683324482969283 0.994067057151257 0.349973628350141 0.597835513378729 miRNATAP -0.120545638662601 7.71590575059167e-05 NA NA NA hsa-miR-27a-3p PGAP1 0.309634509674364 0.703724209648479 -0.0321372382018619 0.932607001535326 miRNATAP -0.107242755564486 0.0360340676736692 NA NA NA hsa-miR-22-3p PHC1 0.0468440219945929 0.967778504781139 -0.279352782259429 0.570528372205872 MirTarget -0.169895225365525 8.61064829626614e-05 NA NA NA hsa-miR-140-3p PHF20L1 -0.105651799466207 0.9077781740714 -0.198521380754143 0.714598913563395 PITA -0.156874531167909 3.68573914645511e-05 NA NA NA hsa-miR-15b-5p PHF21A 0.251826642099145 0.790709218602499 -0.0229500388054138 0.96355078492832 MirTarget -0.109204609123077 0.00350142713071582 NA NA NA hsa-miR-140-3p PHKG2 -0.105651799466207 0.9077781740714 -0.0340232743320463 0.942538253607459 mirMAP -0.110951019933647 0.000326895948387251 NA NA NA hsa-miR-107 PHLDA1 -0.289737369453023 0.769655185893943 -0.0127555088841484 0.980150421236681 miRanda -0.181916902725066 0.0365359948276559 NA NA NA hsa-miR-107 PID1 -0.289737369453023 0.769655185893943 0.168850395556573 0.642927603664984 PITA;miRanda -0.415999216356014 3.96778719091263e-05 NA NA NA hsa-miR-15b-5p PID1 0.251826642099145 0.790709218602499 0.168850395556573 0.642927603664984 MirTarget;miRNATAP -0.33815117690069 0.00132864992620296 NA NA NA hsa-miR-221-3p PIK3R1 -0.261179092929062 0.744019631321393 0.179845155170782 0.739191606793684 MirTarget -0.207116873312359 1.78107159906552e-05 NA NA NA hsa-miR-222-3p PIK3R1 -0.233673471709747 0.726651775432807 0.179845155170782 0.739191606793684 MirTarget -0.210819526678877 1.05428412163985e-05 NA NA NA hsa-miR-27a-3p PIP5K1B 0.309634509674364 0.703724209648479 0.0109415508244106 0.981356867204169 MirTarget -0.389564587096439 0.00132834383980279 NA NA NA hsa-miR-15b-5p PITPNM2 0.251826642099145 0.790709218602499 -0.350595535487645 0.389324347985011 mirMAP -0.151608445959439 0.0311652654122546 NA NA NA hsa-miR-148a-3p PITPNM3 -0.324144803192141 0.746264759480212 -0.129159774944464 0.787380294427841 mirMAP -0.187297362028089 0.00115834547568604 NA NA NA hsa-miR-107 PKD1 -0.289737369453023 0.769655185893943 -0.281338158145099 0.622976438898343 miRanda -0.128205193462833 0.0290273627156004 NA NA NA hsa-miR-107 PKIA -0.289737369453023 0.769655185893943 0.246210914878229 0.603765376989981 miRanda -0.349462493676544 0.0123509280322462 NA NA NA hsa-miR-27a-3p PKIA 0.309634509674364 0.703724209648479 0.246210914878229 0.603765376989981 MirTarget;miRNATAP -0.404752542570459 0.00085099485098208 NA NA NA hsa-miR-27a-3p PKNOX2 0.309634509674364 0.703724209648479 0.436501614750127 0.326720934754083 miRNATAP -0.248979003594665 0.0111263650271573 NA NA NA hsa-miR-222-3p PKP2 -0.233673471709747 0.726651775432807 -0.288605734803742 0.621683168509543 miRNAWalker2_validate -0.154363358117797 0.00280957094170363 NA NA NA hsa-miR-128-3p PLA2G5 -0.0364518492233463 0.95841670253784 0.180702296489151 0.636334791264485 miRNAWalker2_validate -0.402077608202707 0.000489651577825212 NA NA NA hsa-miR-15b-5p PLAG1 0.251826642099145 0.790709218602499 0.206633268792798 0.690698367591079 MirTarget;miRNATAP -0.319399869912002 0.0092108745298099 NA NA NA hsa-miR-98-5p PLAGL1 -0.0484028619275874 0.910781316485549 -0.480710625682777 0.313396838240501 miRNAWalker2_validate -0.157785521787401 0.0215576928352192 NA NA NA hsa-miR-22-3p PLAGL2 0.0468440219945929 0.967778504781139 -0.0546141513819354 0.929591181369687 miRNATAP -0.123141158737007 0.00339634039869923 NA NA NA hsa-miR-22-3p PLCXD3 0.0468440219945929 0.967778504781139 -0.58817649532739 0.365923835413038 miRNATAP -0.441334849824991 0.00309393608330694 NA NA NA hsa-miR-15b-5p PLEKHA5 0.251826642099145 0.790709218602499 -0.0782443041146728 0.8582377270912 MirTarget -0.11547705182825 0.0367993711779671 NA NA NA hsa-miR-22-3p PLEKHG4B 0.0468440219945929 0.967778504781139 -0.659296318691375 0.213793905576961 mirMAP -0.296512723893384 0.000168033363815604 NA NA NA hsa-miR-139-5p PLEKHG6 -0.0625698939687087 0.914810329989088 -0.79093313477156 0.0541145097186795 miRanda -0.198744131164268 0.00764747422047713 NA NA NA hsa-miR-27a-3p PLEKHH2 0.309634509674364 0.703724209648479 -0.139106696356358 0.72648813371358 miRNATAP -0.177723503644473 0.0300264563785027 NA NA NA hsa-miR-27a-3p PLEKHJ1 0.309634509674364 0.703724209648479 0.110026992809783 0.800301002408192 miRNATAP -0.210973077778512 2.93178625139125e-09 NA NA NA hsa-miR-15b-5p PLEKHM3 0.251826642099145 0.790709218602499 -0.0736834045318551 0.851144302277632 MirTarget -0.168832944076564 0.000319779535329022 NA NA NA hsa-miR-128-3p PLK2 -0.0364518492233463 0.95841670253784 0.263197612448985 0.615226064996544 MirTarget -0.217270538549621 0.0148618805400975 NA NA NA hsa-miR-221-3p PLOD2 -0.261179092929062 0.744019631321393 0.0941798242480054 0.874138877907245 miRNAWalker2_validate -0.11666792763322 0.0453114307095464 NA NA NA hsa-miR-15b-5p PLXNA2 0.251826642099145 0.790709218602499 -0.165972689963265 0.757637121079964 MirTarget;miRNATAP -0.165467093080228 0.031397302909633 NA NA NA hsa-miR-127-3p PMCHL2 0.231539840651733 0.822108193638849 -0.407429204891316 0.516459484189933 miRanda -0.22357827277607 0.0211114097203116 NA NA NA hsa-miR-107 PMEPA1 -0.289737369453023 0.769655185893943 0.272139744477033 0.649605523427582 mirMAP -0.396968521258116 4.44556481698755e-05 NA NA NA hsa-miR-107 PNMA2 -0.289737369453023 0.769655185893943 0.852892799017383 0.0740286472342137 miRanda -0.474283044437771 0.000386047907820374 NA NA NA hsa-miR-107 PNMAL1 -0.289737369453023 0.769655185893943 0.0976456815400404 0.843598312844483 miRanda -0.146127086874155 0.0407080487904786 NA NA NA hsa-miR-15b-5p PNMAL2 0.251826642099145 0.790709218602499 -0.00948945445855776 0.975221515796783 MirTarget -0.195187183238563 0.00672006385695196 NA NA NA hsa-miR-22-3p POGK 0.0468440219945929 0.967778504781139 -0.0115733232792978 0.984631863182894 MirTarget -0.106293973298418 5.50193946966233e-06 NA NA NA hsa-miR-221-3p POGZ -0.261179092929062 0.744019631321393 -0.235892612080695 0.706396323124935 miRNAWalker2_validate;MirTarget;miRNATAP -0.106559367520748 0.000846818306236619 NA NA NA hsa-miR-222-3p POGZ -0.233673471709747 0.726651775432807 -0.235892612080695 0.706396323124935 MirTarget;miRNATAP -0.120219577937646 0.000141505699727378 NA NA NA hsa-miR-107 POLDIP3 -0.289737369453023 0.769655185893943 0.126041408089588 0.821396558853154 miRanda -0.143451688646447 1.43549435047125e-05 NA NA NA hsa-miR-127-3p POLR2H 0.231539840651733 0.822108193638849 0.168998778017926 0.759425293528337 miRanda -0.107168842725767 9.40934690574851e-06 NA NA NA hsa-miR-140-3p POU2F1 -0.105651799466207 0.9077781740714 -0.0897505518405097 0.804089556136389 miRNATAP -0.101159458402662 0.00493317240534037 NA NA NA hsa-miR-98-5p POU2F1 -0.0484028619275874 0.910781316485549 -0.0897505518405097 0.804089556136389 miRNAWalker2_validate -0.100174146068798 9.99358191230628e-05 NA NA NA hsa-miR-107 PPARGC1A -0.289737369453023 0.769655185893943 0.229210326094991 0.732721990004139 miRanda -0.664703058278635 0.000769410038554476 NA NA NA hsa-miR-660-5p PPARGC1A -0.561687438133488 0.138270972367544 0.229210326094991 0.732721990004139 MirTarget -0.401809674353636 0.00117803120762303 NA NA NA hsa-miR-98-5p PPARGC1A -0.0484028619275874 0.910781316485549 0.229210326094991 0.732721990004139 miRNAWalker2_validate -0.534634774592048 3.98468956778339e-05 NA NA NA hsa-miR-140-3p PPM1E -0.105651799466207 0.9077781740714 -0.581399323842226 0.104476141184556 PITA -0.194214859365269 0.0466089613715106 NA NA NA hsa-miR-222-3p PPM1H -0.233673471709747 0.726651775432807 -0.231376673890774 0.628806404083338 miRNAWalker2_validate -0.268562441934676 1.25932231136323e-05 NA NA NA hsa-miR-221-3p PPM1L -0.261179092929062 0.744019631321393 0.0646545898150893 0.833664564331168 mirMAP -0.142540621796254 0.0394235005720516 NA NA NA hsa-miR-222-3p PPP1R15B -0.233673471709747 0.726651775432807 0.119709240536804 0.833589551762516 miRNATAP -0.100759036325955 2.26988136778482e-05 NA NA NA hsa-miR-222-3p PPP2R1A -0.233673471709747 0.726651775432807 -0.0909267516111996 0.902810099795045 miRNAWalker2_validate -0.100901724091199 5.87904961517037e-05 NA NA NA hsa-miR-140-3p PPP2R2A -0.105651799466207 0.9077781740714 0.0894716803567892 0.860054904608835 PITA -0.115623103061531 0.00134848401333295 NA NA NA hsa-miR-27a-3p PRDM16 0.309634509674364 0.703724209648479 -0.421541536732908 0.443431196347576 miRNATAP -0.387635170045288 0.00669787953449951 NA NA NA hsa-miR-15b-5p PRKAB2 0.251826642099145 0.790709218602499 -0.0425914327641346 0.921896129536125 MirTarget -0.203802540972703 8.97755216288407e-06 NA NA NA hsa-miR-107 PRKAR2B -0.289737369453023 0.769655185893943 0.126375628714293 0.767754021691009 miRanda -0.249986923023997 0.000604369206896498 NA NA NA hsa-miR-128-3p PRKD1 -0.0364518492233463 0.95841670253784 0.0695626146272637 0.844746418382669 MirTarget -0.181599066986914 0.0230153411578755 NA NA NA hsa-miR-107 PRKG1 -0.289737369453023 0.769655185893943 0.628053453885595 0.0850532587038029 PITA;miRanda;miRNATAP -0.282451724168133 0.00930022086762739 NA NA NA hsa-miR-15b-5p PRMT7 0.251826642099145 0.790709218602499 0.0154030235351819 0.969743625575252 mirMAP -0.13420089978783 0.000205390945373842 NA NA NA hsa-miR-107 PRPS2 -0.289737369453023 0.769655185893943 0.132654529610422 0.798387835976665 miRanda -0.117011481782589 0.0237644489830253 NA NA NA hsa-miR-214-3p PRR15L 0.0312810611346688 0.952640488671912 0.225584482065991 0.661394552629711 MirTarget;miRNATAP -0.125352534543079 0.0270072164792573 NA NA NA hsa-miR-107 PRR5 -0.289737369453023 0.769655185893943 -0.107751043552081 0.789874455685381 miRanda -0.140522359715997 0.00540857342114622 NA NA NA hsa-miR-98-5p PRRG3 -0.0484028619275874 0.910781316485549 -0.438271363333693 0.464513634826601 mirMAP -0.46514303048606 1.19673712652242e-05 NA NA NA hsa-miR-22-3p PRRT2 0.0468440219945929 0.967778504781139 -0.0449048418559226 0.897651077368752 miRNATAP -0.237381412769232 0.000688433381415815 NA NA NA hsa-miR-107 PRRT4 -0.289737369453023 0.769655185893943 -0.11019880211934 0.812372931085144 miRNATAP -0.269190280260806 0.0356971522545947 NA NA NA hsa-miR-27a-3p PRRT4 0.309634509674364 0.703724209648479 -0.11019880211934 0.812372931085144 miRNATAP -0.30165133035757 0.00683670414002915 NA NA NA hsa-miR-107 PRTG -0.289737369453023 0.769655185893943 0.728893879908849 0.0586026605838627 miRanda;miRNATAP -0.446840421440558 8.65288246950172e-05 NA NA NA hsa-miR-15b-5p PRTG 0.251826642099145 0.790709218602499 0.728893879908849 0.0586026605838627 MirTarget -0.715018105109121 6.0168886217655e-10 NA NA NA hsa-miR-221-3p PRTG -0.261179092929062 0.744019631321393 0.728893879908849 0.0586026605838627 mirMAP -0.24801747616276 0.00589869086584545 NA NA NA hsa-miR-222-3p PRTG -0.233673471709747 0.726651775432807 0.728893879908849 0.0586026605838627 mirMAP -0.218669838703352 0.0145513114390954 NA NA NA hsa-miR-107 PRX -0.289737369453023 0.769655185893943 -0.264781709906133 0.396464797669974 mirMAP -0.131963678505916 0.0474882468330128 NA NA NA hsa-miR-381-3p PSIP1 0.269633663970002 0.562625029053898 0.0466864224704349 0.935436890147336 MirTarget -0.112528253033982 0.000572781168714855 NA NA NA hsa-miR-15b-5p PSKH1 0.251826642099145 0.790709218602499 0.00637985193952417 0.989520075243675 MirTarget;miRNATAP -0.252146927853935 1.13853333979636e-10 NA NA NA hsa-miR-222-3p PSMC4 -0.233673471709747 0.726651775432807 -0.00253373973214543 0.996814059006204 miRNAWalker2_validate -0.119399610239256 0.00399633160393218 NA NA NA hsa-miR-127-3p PTBP2 0.231539840651733 0.822108193638849 0.0101102906172699 0.98201841107918 miRanda -0.109085435091481 0.00348824015643427 NA NA NA hsa-miR-15b-5p PTCH1 0.251826642099145 0.790709218602499 -0.128876869443368 0.772081528057187 miRNATAP -0.177708381172835 0.00243070480070398 NA NA NA hsa-miR-221-3p PTCHD1 -0.261179092929062 0.744019631321393 -0.836467355669392 0.172950952034276 mirMAP -0.262651949397208 0.0446222396539873 NA NA NA hsa-miR-363-3p PTGER3 -0.186046567396088 0.728622856049059 1.5042382236434 0.00750024599878325 mirMAP -0.195090129151484 0.0111893840107225 NA NA NA hsa-miR-107 PTGIS -0.289737369453023 0.769655185893943 0.708673313204939 0.233374004519277 miRanda -0.45895937230738 0.000191471571500375 NA NA NA hsa-miR-22-3p PTMS 0.0468440219945929 0.967778504781139 0.187086412232667 0.812010182196003 miRNAWalker2_validate;miRTarBase -0.124840407541086 0.0013541898063031 NA NA NA hsa-miR-107 PTPN13 -0.289737369453023 0.769655185893943 -0.118911044770142 0.843548078156716 miRanda -0.325278017929708 0.0278221597058042 NA NA NA hsa-miR-148a-3p PTPN14 -0.324144803192141 0.746264759480212 0.0640945989806028 0.88112748225223 MirTarget;miRNATAP -0.125773659379551 0.00301631556968832 NA NA NA hsa-miR-139-5p PTPRO -0.0625698939687087 0.914810329989088 -0.0470623163469455 0.889506548719835 miRanda -0.15722197267573 0.0232294579639625 NA NA NA hsa-miR-150-5p PTPRT -0.00683324482969283 0.994067057151257 1.26309147338408 0.131785433872241 mirMAP -0.314654889609647 0.00849478764676735 NA NA NA hsa-miR-107 PURG -0.289737369453023 0.769655185893943 0.119181666258185 0.790364135546391 miRanda -0.270468523614843 0.0310149866401141 NA NA NA hsa-miR-107 PWWP2B -0.289737369453023 0.769655185893943 0.130397728414171 0.774733655350266 miRNATAP -0.120047016346125 0.0100232828889516 NA NA NA hsa-miR-140-3p PYCRL -0.105651799466207 0.9077781740714 0.0792590669681008 0.877484713479432 mirMAP -0.22461367792228 8.52187440723636e-05 NA NA NA hsa-miR-139-5p PYROXD1 -0.0625698939687087 0.914810329989088 0.324261896314824 0.426700469660031 miRanda -0.107053352036801 0.0067756585473485 NA NA NA hsa-miR-127-3p PYROXD2 0.231539840651733 0.822108193638849 -0.204452019842756 0.571113407161471 miRanda -0.148608250356679 0.00300228407956668 NA NA NA hsa-miR-150-5p QSOX2 -0.00683324482969283 0.994067057151257 -0.136054280096601 0.740534624178366 mirMAP -0.110606764488976 4.09995889609151e-07 NA NA NA hsa-miR-15b-5p RAB11FIP2 0.251826642099145 0.790709218602499 0.40796246475975 0.390424686419944 MirTarget;miRNATAP -0.157421190478006 0.00223085120900179 NA NA NA hsa-miR-128-3p RAB20 -0.0364518492233463 0.95841670253784 0.21643465232716 0.622700124000527 MirTarget -0.121279322268143 0.0306388530717531 NA NA NA hsa-miR-22-3p RAB28 0.0468440219945929 0.967778504781139 0.00500086875734862 0.989445493140187 MirTarget -0.111651977506877 0.000206839632654452 NA NA NA hsa-miR-107 RAB37 -0.289737369453023 0.769655185893943 -0.0678665561639503 0.801799409694824 miRanda -0.17782594185439 0.0243240144590729 NA NA NA hsa-miR-15b-5p RAB37 0.251826642099145 0.790709218602499 -0.0678665561639503 0.801799409694824 mirMAP -0.22767953236208 0.00522431885163684 NA NA NA hsa-miR-214-3p RAB39B 0.0312810611346688 0.952640488671912 0.108587482783994 0.755483545334207 MirTarget -0.100204313867329 0.0376818002415697 NA NA NA hsa-miR-15b-5p RAB6B 0.251826642099145 0.790709218602499 0.25499690713575 0.610671139960455 mirMAP -0.156464764620171 0.026994233454671 NA NA NA hsa-miR-363-3p RAB6B -0.186046567396088 0.728622856049059 0.25499690713575 0.610671139960455 mirMAP -0.108924126860862 0.000854232071469155 NA NA NA hsa-miR-15b-5p RAB9B 0.251826642099145 0.790709218602499 -0.456852331489163 0.25388961484004 miRNATAP -0.26364045286316 0.0107567401771477 NA NA NA hsa-miR-221-3p RACGAP1 -0.261179092929062 0.744019631321393 0.0481665178996566 0.926277360869014 miRNAWalker2_validate -0.121284794523858 0.00317082905986859 NA NA NA hsa-miR-127-3p RAD9A 0.231539840651733 0.822108193638849 -0.153181494059183 0.699997889067489 miRanda;miRNATAP -0.106717103557534 4.46003097466537e-06 NA NA NA hsa-miR-150-5p RADIL -0.00683324482969283 0.994067057151257 0.0950694612290111 0.821511996013504 mirMAP -0.133475142722219 0.0235142818818496 NA NA NA hsa-miR-148a-3p RAI14 -0.324144803192141 0.746264759480212 0.0965787852806113 0.86653189464539 MirTarget -0.130945463181297 0.0111748545535761 NA NA NA hsa-miR-148a-3p RALGPS1 -0.324144803192141 0.746264759480212 -0.223412409373529 0.602341853925744 mirMAP -0.120843104036247 0.0034168588777847 NA NA NA hsa-miR-197-3p RALGPS1 0.0240027695773914 0.981971058073739 -0.223412409373529 0.602341853925744 miRNATAP -0.19541349124182 0.00033308473429568 NA NA NA hsa-miR-15b-5p RANBP10 0.251826642099145 0.790709218602499 -0.168749543564748 0.714373377843494 miRNAWalker2_validate;mirMAP -0.12013844076915 0.00235877561114348 NA NA NA hsa-miR-222-3p RAP1GAP2 -0.233673471709747 0.726651775432807 -0.396747626151487 0.419794571173759 miRNAWalker2_validate -0.179715492569592 0.00882934029547843 NA NA NA hsa-miR-15b-5p RAPGEF2 0.251826642099145 0.790709218602499 -0.177866081352616 0.661243598364709 miRNATAP -0.116008667039147 0.00515366681483131 NA NA NA hsa-miR-127-3p RAPGEF3 0.231539840651733 0.822108193638849 0.42116693587348 0.48319683956781 miRanda -0.110861231885597 0.0448096275067771 NA NA NA hsa-miR-107 RARB -0.289737369453023 0.769655185893943 0.74003577086304 0.0380123435177395 miRanda -0.202220432887224 0.0146841176579394 NA NA NA hsa-miR-15b-5p RASA4 0.251826642099145 0.790709218602499 -0.152044566952539 0.710915884115039 mirMAP -0.121655360144953 0.0315324067427922 NA NA NA hsa-miR-214-3p RASEF 0.0312810611346688 0.952640488671912 -0.403334380279583 0.266893169484835 MirTarget -0.199069256294127 5.9276500449734e-05 NA NA NA hsa-miR-107 RASL12 -0.289737369453023 0.769655185893943 0.135440723734943 0.683089331172494 miRNATAP -0.16188785461667 0.0161257020106291 NA NA NA hsa-miR-15b-5p RASL12 0.251826642099145 0.790709218602499 0.135440723734943 0.683089331172494 miRNATAP -0.205940807398858 0.0030220706813014 NA NA NA hsa-miR-107 RASSF8 -0.289737369453023 0.769655185893943 -0.0372484633947416 0.939873761407767 miRanda;miRNATAP -0.35151830858354 0.00062043452426105 NA NA NA hsa-miR-214-3p RAX2 0.0312810611346688 0.952640488671912 -0.139182355951872 0.821567837593563 mirMAP -0.333870364827163 0.000119213510362658 NA NA NA hsa-miR-140-3p RBM15B -0.105651799466207 0.9077781740714 -0.0776201449520606 0.896810037136899 PITA -0.119387017770286 1.98354400889807e-05 NA NA NA hsa-miR-107 RBMS3 -0.289737369453023 0.769655185893943 0.161532142045121 0.632183509346894 miRanda -0.269456315604729 0.00716590406581893 NA NA NA hsa-miR-22-3p RBMXL1 0.0468440219945929 0.967778504781139 -0.0941880589804507 0.855311454757308 MirTarget -0.140543678077435 1.70207005398913e-08 NA NA NA hsa-miR-27a-3p RBPMS2 0.309634509674364 0.703724209648479 -0.446890958835056 0.206057063891508 miRNATAP -0.302696913210883 7.24374032104023e-05 NA NA NA hsa-miR-107 RCAN2 -0.289737369453023 0.769655185893943 0.111174410976524 0.760340162186607 miRanda -0.151823322840372 0.0301883007984325 NA NA NA hsa-miR-107 RECK -0.289737369453023 0.769655185893943 0.240278891878698 0.465133407499922 miRanda -0.197538460806406 0.000277554359640023 NA NA NA hsa-miR-214-3p REEP2 0.0312810611346688 0.952640488671912 0.170792853091597 0.662677842192033 mirMAP -0.108617290263007 0.0174032495554908 NA NA NA hsa-miR-221-3p REV3L -0.261179092929062 0.744019631321393 -0.0343735837358246 0.934599358241077 miRNATAP -0.109322818727112 0.00712315737536437 NA NA NA hsa-miR-222-3p REV3L -0.233673471709747 0.726651775432807 -0.0343735837358246 0.934599358241077 miRNATAP -0.113437222825021 0.00486155310470137 NA NA NA hsa-miR-140-3p RFT1 -0.105651799466207 0.9077781740714 0.071013176990574 0.875410399983397 miRNATAP -0.108032028164759 0.000918332813556308 NA NA NA hsa-miR-148a-3p RGMA -0.324144803192141 0.746264759480212 -0.0868040418355855 0.866269824908491 miRNATAP -0.203831046930791 0.00333299375106034 NA NA NA hsa-miR-150-5p RHBDL3 -0.00683324482969283 0.994067057151257 -0.445360275416062 0.36566157903762 mirMAP -0.158575055994567 0.0202567226135721 NA NA NA hsa-miR-27a-3p RHOBTB1 0.309634509674364 0.703724209648479 -0.0427306441823729 0.911470655663495 miRNATAP -0.197476889142609 0.000427645968087278 NA NA NA hsa-miR-98-5p RHOBTB3 -0.0484028619275874 0.910781316485549 0.499649335882288 0.290603099898554 miRNAWalker2_validate -0.152370371581659 0.00662998077122311 NA NA NA hsa-miR-15b-5p RIMKLB 0.251826642099145 0.790709218602499 -0.11484491184931 0.798695483786031 MirTarget;miRNATAP -0.106959138460666 0.0353651980070886 NA NA NA hsa-miR-107 RIMS3 -0.289737369453023 0.769655185893943 -0.844845493168377 0.0188893838516097 MirTarget;miRanda;miRNATAP -0.227204424686387 0.0134688705948389 NA NA NA hsa-miR-221-3p RIMS3 -0.261179092929062 0.744019631321393 -0.844845493168377 0.0188893838516097 MirTarget;miRNATAP -0.374761394496907 1.26742429273102e-07 NA NA NA hsa-miR-222-3p RIMS3 -0.233673471709747 0.726651775432807 -0.844845493168377 0.0188893838516097 MirTarget;miRNATAP -0.33887940845518 1.62503526163207e-06 NA NA NA hsa-miR-363-3p RIMS3 -0.186046567396088 0.728622856049059 -0.844845493168377 0.0188893838516097 mirMAP -0.120348942373461 0.00637113610038577 NA NA NA hsa-miR-221-3p RND2 -0.261179092929062 0.744019631321393 -0.149499377774948 0.710812385652947 miRNATAP -0.440821536492831 5.46151187083554e-07 NA NA NA hsa-miR-222-3p RND2 -0.233673471709747 0.726651775432807 -0.149499377774948 0.710812385652947 miRNATAP -0.39993309723228 5.0193858272833e-06 NA NA NA hsa-miR-128-3p RND3 -0.0364518492233463 0.95841670253784 -0.177158523229606 0.738936292787085 MirTarget -0.1696008397914 0.0184619052369757 NA NA NA hsa-miR-98-5p RND3 -0.0484028619275874 0.910781316485549 -0.177158523229606 0.738936292787085 miRNAWalker2_validate -0.126844785410505 0.00541117236736454 NA NA NA hsa-miR-15b-5p RNF111 0.251826642099145 0.790709218602499 0.124748007892266 0.789366207632001 miRNATAP -0.10268771781242 0.00748384597330108 NA NA NA hsa-miR-139-5p RNF144A -0.0625698939687087 0.914810329989088 0.216002153487048 0.654723864324535 miRanda -0.105515165345172 0.0331693785154756 NA NA NA hsa-miR-148a-3p ROBO2 -0.324144803192141 0.746264759480212 -0.0317331177133265 0.943678653338893 miRNATAP -0.277812185340372 0.00790245294708686 NA NA NA hsa-miR-107 ROR1 -0.289737369453023 0.769655185893943 0.123791801842217 0.762992617950311 MirTarget;miRNATAP -0.17779560032767 0.0476084313386362 NA NA NA hsa-miR-27a-3p RORA 0.309634509674364 0.703724209648479 -0.106864420903452 0.76004561832972 mirMAP;miRNATAP -0.12744981856874 0.026750783314866 NA NA NA hsa-miR-107 RPL10 -0.289737369453023 0.769655185893943 0.0959738961819454 0.908641293809852 miRanda -0.235829714069353 1.04194968268601e-05 NA NA NA hsa-miR-22-3p RPL13 0.0468440219945929 0.967778504781139 0.469948641246376 0.603572845225541 MirTarget -0.215032481224803 4.74533011463888e-06 NA NA NA hsa-miR-197-3p RPL13A 0.0240027695773914 0.981971058073739 0.312781987413061 0.663891492149961 miRNAWalker2_validate -0.138015939536946 0.0213243096244712 NA NA NA hsa-miR-197-3p RPL22 0.0240027695773914 0.981971058073739 0.107062411048224 0.884260173817056 miRNAWalker2_validate -0.13412798645183 0.00521970041570858 NA NA NA hsa-miR-22-3p RPL24 0.0468440219945929 0.967778504781139 0.415560459468432 0.57289919111451 miRNAWalker2_validate -0.277610536501522 1.9402199991847e-11 NA NA NA hsa-miR-107 RPL27 -0.289737369453023 0.769655185893943 0.446713100165292 0.601582581088733 miRNAWalker2_validate -0.201224028478129 0.00174763604842161 NA NA NA hsa-miR-15b-5p RPL27A 0.251826642099145 0.790709218602499 0.395718819061685 0.62174323262406 miRNAWalker2_validate -0.158373288963581 0.0139240882665722 NA NA NA hsa-miR-128-3p RPL28 -0.0364518492233463 0.95841670253784 0.34263517940111 0.724499615995287 miRNAWalker2_validate -0.113839169738349 0.0481909276295563 NA NA NA hsa-miR-140-3p RPL28 -0.105651799466207 0.9077781740714 0.34263517940111 0.724499615995287 mirMAP -0.126802113304509 0.0123731440676046 NA NA NA hsa-miR-107 RPL32 -0.289737369453023 0.769655185893943 0.430467943148424 0.620231018841522 miRanda -0.166595466126211 0.00373098724068369 NA NA NA hsa-miR-107 RPL34 -0.289737369453023 0.769655185893943 0.423071604360283 0.545254545872231 miRanda -0.137948599723444 0.0197298730030315 NA NA NA hsa-miR-22-3p RPL35A 0.0468440219945929 0.967778504781139 0.44763490166746 0.594886845159278 miRNAWalker2_validate -0.235740012790426 3.3788657477439e-07 NA NA NA hsa-miR-381-3p RPL37 0.269633663970002 0.562625029053898 0.381374601741255 0.659861779181283 MirTarget -0.11274569095006 0.00153668345211754 NA NA NA hsa-miR-660-5p RPL37 -0.561687438133488 0.138270972367544 0.381374601741255 0.659861779181283 mirMAP -0.127869331604885 0.000310402233730636 NA NA NA hsa-miR-107 RPL5 -0.289737369453023 0.769655185893943 0.281783953809873 0.751162391690708 miRanda -0.187566608224084 0.000338159180118219 NA NA NA hsa-miR-15b-5p RPLP0 0.251826642099145 0.790709218602499 0.289170800840475 0.748792108206182 miRNAWalker2_validate -0.145908024310767 0.00901657664028096 NA NA NA hsa-miR-107 RPS19 -0.289737369453023 0.769655185893943 0.27636968755613 0.745174922819393 miRanda -0.171007815852254 0.00431756598106354 NA NA NA hsa-miR-22-3p RPS2 0.0468440219945929 0.967778504781139 0.213947913171545 0.803508778963472 miRNAWalker2_validate -0.189248939791968 1.88820904528945e-06 NA NA NA hsa-miR-15b-5p RPS3A 0.251826642099145 0.790709218602499 0.357208884764124 0.598443743648107 miRNAWalker2_validate -0.133599666344082 0.0411639662664775 NA NA NA hsa-miR-22-3p RPS4X 0.0468440219945929 0.967778504781139 0.32392101190641 0.735179813082882 miRNAWalker2_validate -0.264971624015455 6.85886693619226e-10 NA NA NA hsa-miR-221-3p RPS7 -0.261179092929062 0.744019631321393 0.578407496374309 0.364461275867134 miRNAWalker2_validate -0.200438582236913 1.33310685962625e-05 NA NA NA hsa-miR-107 RPSA -0.289737369453023 0.769655185893943 0.292708372647978 0.663661434401365 miRNAWalker2_validate -0.135692015405418 0.0193898204881825 NA NA NA hsa-miR-22-3p RPSA 0.0468440219945929 0.967778504781139 0.292708372647978 0.663661434401365 miRNAWalker2_validate -0.197954807985867 6.81912112983427e-06 NA NA NA hsa-miR-15b-5p RSBN1 0.251826642099145 0.790709218602499 -0.154708510116565 0.73194302907544 MirTarget;miRNATAP -0.146546310493701 3.97248127361801e-05 NA NA NA hsa-miR-22-3p RSBN1 0.0468440219945929 0.967778504781139 -0.154708510116565 0.73194302907544 MirTarget;miRNATAP -0.166822654456481 1.21040636980985e-10 NA NA NA hsa-miR-107 RSL24D1 -0.289737369453023 0.769655185893943 0.46030178817281 0.400820405815939 miRanda -0.135994745699676 0.00386690832018473 NA NA NA hsa-miR-221-3p RUNDC3B -0.261179092929062 0.744019631321393 -0.0739775551039484 0.797144274795367 miRNAWalker2_validate -0.184187848351778 0.00549722355295424 NA NA NA hsa-miR-148a-3p RUNX1T1 -0.324144803192141 0.746264759480212 0.368230121873391 0.426434278656151 miRNATAP -0.26896168971416 0.0143322359174856 NA NA NA hsa-miR-15b-5p SALL1 0.251826642099145 0.790709218602499 0.280191846617212 0.657573081603446 MirTarget;miRNATAP -0.699291401488615 0.000332246297685377 NA NA NA hsa-miR-107 SALL4 -0.289737369453023 0.769655185893943 -0.510631590858331 0.266073078661525 PITA;miRanda;miRNATAP -0.343825619948558 0.0103877110710336 NA NA NA hsa-miR-150-5p SAMD5 -0.00683324482969283 0.994067057151257 0.172708926466839 0.592027749121823 mirMAP -0.114824758863637 0.0101685236665009 NA NA NA hsa-miR-15b-5p SATB2 0.251826642099145 0.790709218602499 -0.663000165483578 0.0472334757509491 miRNATAP -0.205949463003812 0.0431697329847094 NA NA NA hsa-miR-139-5p SBK1 -0.0625698939687087 0.914810329989088 -0.514426451142808 0.304097974116027 PITA;miRanda -0.175897641147563 0.00937779007539073 NA NA NA hsa-miR-221-3p SBK1 -0.261179092929062 0.744019631321393 -0.514426451142808 0.304097974116027 miRNATAP -0.343471682742135 7.82999130410168e-08 NA NA NA hsa-miR-222-3p SBK1 -0.233673471709747 0.726651775432807 -0.514426451142808 0.304097974116027 miRNATAP -0.29488321044041 3.87630150530919e-06 NA NA NA hsa-miR-107 SCAMP5 -0.289737369453023 0.769655185893943 0.270420817325495 0.534796171317991 MirTarget;PITA;miRNATAP -0.122206761484449 0.0440745701087857 NA NA NA hsa-miR-107 SCHIP1 -0.289737369453023 0.769655185893943 0.373312951254524 0.314200418398264 miRanda -0.162482417546162 0.0155282138733367 NA NA NA hsa-miR-98-5p SCHIP1 -0.0484028619275874 0.910781316485549 0.373312951254524 0.314200418398264 miRNAWalker2_validate -0.126260270328295 0.00440776620029997 NA NA NA hsa-miR-221-3p SCN11A -0.261179092929062 0.744019631321393 -0.105497784722535 0.815957407872485 MirTarget -0.287356526000901 0.00324532397569311 NA NA NA hsa-miR-222-3p SCN11A -0.233673471709747 0.726651775432807 -0.105497784722535 0.815957407872485 MirTarget -0.30957807405111 0.0013716528281449 NA NA NA hsa-miR-660-5p SCN2A -0.561687438133488 0.138270972367544 0.388866325627938 0.447580543628337 MirTarget -0.219378613237614 0.0199114090632024 NA NA NA hsa-miR-107 SCN7A -0.289737369453023 0.769655185893943 0.292265359386536 0.598616017397583 miRanda -0.358554960135577 0.0268402622719493 NA NA NA hsa-miR-98-5p SCUBE3 -0.0484028619275874 0.910781316485549 -0.353187464237361 0.500293845388761 mirMAP -0.345629978389189 0.000591788621314637 NA NA NA hsa-miR-22-3p SCYL3 0.0468440219945929 0.967778504781139 0.0612511438713583 0.869363850106949 MirTarget -0.10725537783532 1.54861884640002e-06 NA NA NA hsa-miR-27a-3p SDC2 0.309634509674364 0.703724209648479 0.505229029676173 0.355989708133649 miRNATAP -0.218488005426786 0.00298953878296376 NA NA NA hsa-miR-140-3p SDC4 -0.105651799466207 0.9077781740714 0.091589978224178 0.901144306719051 MirTarget -0.105542930502948 0.0431689061844167 NA NA NA hsa-miR-15b-5p SEC14L5 0.251826642099145 0.790709218602499 0.0448946605966545 0.90662873124006 mirMAP -0.307043887184664 0.00813943155982171 NA NA NA hsa-miR-148a-3p SEMA5A -0.324144803192141 0.746264759480212 0.129982216863797 0.797651199757957 mirMAP -0.17724687031974 0.03829415475493 NA NA NA hsa-miR-660-5p SEMA5A -0.561687438133488 0.138270972367544 0.129982216863797 0.797651199757957 mirMAP -0.160110721195906 0.0175277855429866 NA NA NA hsa-miR-107 SEMA6A -0.289737369453023 0.769655185893943 -0.0388807728352623 0.931906595268609 MirTarget;PITA;miRanda;miRNATAP -0.299426126642775 0.00532498934342631 NA NA NA hsa-miR-15b-5p SEMA6A 0.251826642099145 0.790709218602499 -0.0388807728352623 0.931906595268609 miRNATAP -0.448166714888371 4.88592298989109e-05 NA NA NA hsa-miR-27a-3p SEMA6A 0.309634509674364 0.703724209648479 -0.0388807728352623 0.931906595268609 MirTarget;miRNATAP -0.3793828624656 4.53650156920796e-05 NA NA NA hsa-miR-27a-3p SEMA6D 0.309634509674364 0.703724209648479 0.26918388256722 0.545190021393729 mirMAP;miRNATAP -0.147175994596083 0.0438730290467612 NA NA NA hsa-miR-15b-5p SEMA7A 0.251826642099145 0.790709218602499 -0.0979445084521475 0.780913223971977 mirMAP -0.169783837674787 0.00865276542485129 NA NA NA hsa-miR-140-3p SENP2 -0.105651799466207 0.9077781740714 0.015835816529953 0.974849266008929 mirMAP -0.109397083290457 0.00110439552384191 NA NA NA hsa-miR-22-3p SEPHS1 0.0468440219945929 0.967778504781139 0.0662487242888234 0.904108420401142 MirTarget;miRNATAP -0.111041371404203 0.00126639968327824 NA NA NA hsa-miR-221-3p SEPHS1 -0.261179092929062 0.744019631321393 0.0662487242888234 0.904108420401142 miRNAWalker2_validate -0.20653118983443 2.16495266020015e-09 NA NA NA hsa-miR-139-5p SEPT3 -0.0625698939687087 0.914810329989088 0.0873690218339673 0.816851401663324 PITA;miRanda -0.143023717794118 0.0464294747776771 NA NA NA hsa-miR-107 SEPT5 -0.289737369453023 0.769655185893943 -0.65077366406282 0.149174549959677 miRNATAP -0.177872888769527 0.028605405819385 NA NA NA hsa-miR-107 SERPINB5 -0.289737369453023 0.769655185893943 -0.226978629000397 0.719507712167247 MirTarget;miRanda -0.411085302764306 0.0307173007689843 NA NA NA hsa-miR-15b-5p SESN1 0.251826642099145 0.790709218602499 0.218778816354514 0.568533794057563 MirTarget;miRNATAP -0.228920802180496 6.49709200314064e-07 NA NA NA hsa-miR-22-3p SESN1 0.0468440219945929 0.967778504781139 0.218778816354514 0.568533794057563 MirTarget -0.169381889173291 6.98725445868371e-07 NA NA NA hsa-miR-148a-3p SESTD1 -0.324144803192141 0.746264759480212 -0.365825887576899 0.409803832964815 miRNAWalker2_validate;MirTarget;miRNATAP -0.141145665836456 0.0213338260591289 NA NA NA hsa-miR-98-5p SESTD1 -0.0484028619275874 0.910781316485549 -0.365825887576899 0.409803832964815 MirTarget -0.195820340381351 0.00011114093941838 NA NA NA hsa-miR-27a-3p SFRP1 0.309634509674364 0.703724209648479 0.249499069395879 0.676671825793369 MirTarget;miRNATAP -0.330149862048713 0.012208271649274 NA NA NA hsa-miR-15b-5p SFT2D3 0.251826642099145 0.790709218602499 0.209180235218954 0.626753176552513 MirTarget -0.105008199153152 0.0117689831932862 NA NA NA hsa-miR-15b-5p SGCD 0.251826642099145 0.790709218602499 0.588963498793269 0.197618855406376 miRNATAP -0.270797846270193 0.0161421166898019 NA NA NA hsa-miR-150-5p SH2D5 -0.00683324482969283 0.994067057151257 -0.679029740750115 0.0691880987937774 mirMAP -0.136817568070378 0.00505086222974839 NA NA NA hsa-miR-15b-5p SH3BGRL2 0.251826642099145 0.790709218602499 0.0934765080598625 0.844116989544164 miRNATAP -0.283373009087527 7.15881795284859e-05 NA NA NA hsa-miR-27a-3p SH3BGRL2 0.309634509674364 0.703724209648479 0.0934765080598625 0.844116989544164 miRNATAP -0.288645333629101 1.37161433016012e-06 NA NA NA hsa-miR-107 SH3GL2 -0.289737369453023 0.769655185893943 -0.174297188659928 0.776655663692274 PITA;miRanda;miRNATAP -0.377380585548352 0.0291766653158415 NA NA NA hsa-miR-107 SH3PXD2A -0.289737369453023 0.769655185893943 0.275906232442527 0.638094470813096 PITA;mirMAP -0.135215113057022 0.041349387689217 NA NA NA hsa-miR-27a-3p SHE 0.309634509674364 0.703724209648479 -0.229976916108664 0.39750503056915 MirTarget -0.12907964260342 0.0282717117337328 NA NA NA hsa-miR-150-5p SHH -0.00683324482969283 0.994067057151257 -1.23033150413094 0.0914303555498377 mirMAP -0.393491733771372 1.23922727527381e-05 NA NA NA hsa-miR-15b-5p SHROOM4 0.251826642099145 0.790709218602499 0.00808181304420419 0.984208399410339 miRNATAP -0.236331266130922 0.00210427111516721 NA NA NA hsa-miR-15b-5p SIAH1 0.251826642099145 0.790709218602499 0.108977383960605 0.813939321510207 miRNATAP -0.115044616438337 0.00204983347244596 NA NA NA hsa-miR-15b-5p SIDT2 0.251826642099145 0.790709218602499 0.231119593783537 0.67853077394684 miRNATAP -0.115535966962663 0.0143820904958486 NA NA NA hsa-miR-15b-5p SIPA1L2 0.251826642099145 0.790709218602499 0.0228264886885707 0.960734606692957 miRNATAP -0.195013360670696 0.0046928320228576 NA NA NA hsa-miR-15b-5p SIRT4 0.251826642099145 0.790709218602499 0.068755968003246 0.744728329557899 MirTarget -0.200381127063114 0.00127538234131501 NA NA NA hsa-miR-139-5p SIX4 -0.0625698939687087 0.914810329989088 0.00601229681179927 0.990165128399768 miRanda -0.152655501688566 0.000968391472211355 NA NA NA hsa-miR-148a-3p SIX4 -0.324144803192141 0.746264759480212 0.00601229681179927 0.990165128399768 miRNATAP -0.130049114822075 0.00392468331548636 NA NA NA hsa-miR-107 SIX5 -0.289737369453023 0.769655185893943 -0.0895234366406772 0.868967733447291 mirMAP -0.168529103729667 0.000130277277622181 NA NA NA hsa-miR-140-3p SLC10A4 -0.105651799466207 0.9077781740714 -0.646793378078498 0.173404879141603 miRNATAP -0.266458071984974 0.0357202027906586 NA NA NA hsa-miR-15b-5p SLC13A3 0.251826642099145 0.790709218602499 0.552922073271358 0.160240189445075 miRNATAP -0.288942470216505 0.00665506246594627 NA NA NA hsa-miR-150-5p SLC16A12 -0.00683324482969283 0.994067057151257 0.154442523868255 0.792553606510747 MirTarget -0.444298716176835 5.90013159190239e-09 NA NA NA hsa-miR-140-3p SLC19A1 -0.105651799466207 0.9077781740714 -0.171141947376898 0.656532222592474 mirMAP -0.105599120780875 0.017046027820587 NA NA NA hsa-miR-150-5p SLC22A23 -0.00683324482969283 0.994067057151257 -0.432800962975415 0.382375583304495 mirMAP -0.105592763812875 0.00244713540103495 NA NA NA hsa-miR-15b-5p SLC25A26 0.251826642099145 0.790709218602499 0.114732886743223 0.757371443225099 mirMAP -0.102050468300629 0.00406894035131048 NA NA NA hsa-miR-197-3p SLC25A37 0.0240027695773914 0.981971058073739 -0.220719360527248 0.605051373219336 mirMAP -0.135303649271352 0.0137036896787542 NA NA NA hsa-miR-27a-3p SLC35F1 0.309634509674364 0.703724209648479 0.110539220111251 0.806830378007067 miRNATAP -0.256633640208991 0.0239565822660091 NA NA NA hsa-miR-660-5p SLC35F1 -0.561687438133488 0.138270972367544 0.110539220111251 0.806830378007067 miRNATAP -0.383047643628933 1.88270780436249e-06 NA NA NA hsa-miR-22-3p SLC39A10 0.0468440219945929 0.967778504781139 -0.0324057610934929 0.951393362723483 miRNATAP -0.185979454436773 4.48512311416522e-06 NA NA NA hsa-miR-107 SLC40A1 -0.289737369453023 0.769655185893943 0.13984560920229 0.844826272653304 miRanda -0.189405016332322 0.0388761579871402 NA NA NA hsa-miR-197-3p SLC45A4 0.0240027695773914 0.981971058073739 -0.307908912393824 0.590897732601942 mirMAP -0.197333861777358 0.00108499463313865 NA NA NA hsa-miR-197-3p SLC47A2 0.0240027695773914 0.981971058073739 -0.271594435525068 0.57329213826486 MirTarget -0.367203593683702 0.0125923408539733 NA NA NA hsa-miR-15b-5p SLC4A4 0.251826642099145 0.790709218602499 0.145859114640415 0.707510198586525 MirTarget;miRNATAP -0.257948932009098 0.0236254065320699 NA NA NA hsa-miR-381-3p SLC7A11 0.269633663970002 0.562625029053898 -0.546192374168312 0.213498746002808 mirMAP -0.1435319879994 0.020228120110276 NA NA NA hsa-miR-214-3p SLC7A8 0.0312810611346688 0.952640488671912 0.115091409221363 0.841294243198694 miRNATAP -0.110805162804914 0.00402397622847998 NA NA NA hsa-miR-150-5p SLIT1 -0.00683324482969283 0.994067057151257 0.0610725093475897 0.907592153215612 mirMAP -0.25203985208806 0.000564180296071805 NA NA NA hsa-miR-107 SMAD6 -0.289737369453023 0.769655185893943 0.117020356196165 0.809104774559833 miRanda -0.134392470850536 0.0368618356060279 NA NA NA hsa-miR-27a-3p SMAD9 0.309634509674364 0.703724209648479 -0.225911828351078 0.494493897259927 MirTarget;miRNATAP -0.229182337833288 0.00703318324976007 NA NA NA hsa-miR-128-3p SMARCA2 -0.0364518492233463 0.95841670253784 0.0232780724218085 0.9677385044186 MirTarget -0.214045802403316 0.00264051945962438 NA NA NA hsa-miR-222-3p SMARCA4 -0.233673471709747 0.726651775432807 0.00432489768303235 0.995035116273072 miRNAWalker2_validate -0.123378086106077 0.00405403775730298 NA NA NA hsa-miR-222-3p SMC6 -0.233673471709747 0.726651775432807 0.218230951901899 0.616398369548422 miRNAWalker2_validate -0.104745480873173 0.000506276502630655 NA NA NA hsa-miR-107 SNAI2 -0.289737369453023 0.769655185893943 0.500941280008221 0.27786604895158 miRanda -0.234207164786582 0.0202107019219599 NA NA NA hsa-miR-27a-3p SNN 0.309634509674364 0.703724209648479 -0.0541629523540132 0.908074694474143 miRNATAP -0.162493902087489 0.00150034720490445 NA NA NA hsa-miR-107 SNX18 -0.289737369453023 0.769655185893943 0.212273590968778 0.656791971001171 miRanda;miRNATAP -0.123201299549421 0.00227407495099492 NA NA NA hsa-miR-15b-5p SNX21 0.251826642099145 0.790709218602499 0.0850409386386737 0.83041161190719 mirMAP -0.105204418741291 0.00530716037214823 NA NA NA hsa-miR-222-3p SNX4 -0.233673471709747 0.726651775432807 -0.078369830421142 0.872238532699247 MirTarget -0.118201507605213 1.54335503592314e-06 NA NA NA hsa-miR-107 SOCS2 -0.289737369453023 0.769655185893943 -0.505615702767771 0.0806726513396641 miRanda -0.155192919970033 0.0343051880321477 NA NA NA hsa-miR-148a-3p SOX11 -0.324144803192141 0.746264759480212 0.942365499639792 0.261560242434896 miRNATAP -0.800415000936596 5.74365372493216e-05 NA NA NA hsa-miR-27a-3p SOX11 0.309634509674364 0.703724209648479 0.942365499639792 0.261560242434896 miRNATAP -0.497201689220818 0.0242529620573791 NA NA NA hsa-miR-140-3p SOX12 -0.105651799466207 0.9077781740714 -0.0690861748878868 0.913116184656001 MirTarget;PITA;miRNATAP -0.148208041918136 0.00414541063057905 NA NA NA hsa-miR-214-3p SOX12 0.0312810611346688 0.952640488671912 -0.0690861748878868 0.913116184656001 mirMAP -0.11648339483912 0.000110929771771017 NA NA NA hsa-miR-22-3p SOX13 0.0468440219945929 0.967778504781139 0.0392133635488072 0.9463522475342 MirTarget -0.136850954214571 0.00107632006108242 NA NA NA hsa-miR-98-5p SOX4 -0.0484028619275874 0.910781316485549 -0.307226323554338 0.652796780458641 miRNAWalker2_validate -0.171401781306128 1.13321269428639e-05 NA NA NA hsa-miR-15b-5p SOX6 0.251826642099145 0.790709218602499 -0.346434606181844 0.458702400007528 MirTarget;miRNATAP -0.481168702526696 4.22755629587749e-05 NA NA NA hsa-miR-27a-3p SP6 0.309634509674364 0.703724209648479 0.189165611967267 0.633896782786699 miRNATAP -0.19978195438846 0.0351698090173476 NA NA NA hsa-miR-221-3p SPAG5 -0.261179092929062 0.744019631321393 -0.361656167257142 0.430121201430481 miRNAWalker2_validate -0.159527825312009 0.0013493892585423 NA NA NA hsa-miR-15b-5p SPAG7 0.251826642099145 0.790709218602499 0.0591761076466382 0.895555864769221 miRNATAP -0.131896551828949 0.000293813121545473 NA NA NA hsa-miR-139-5p SPATA17 -0.0625698939687087 0.914810329989088 0.00857720041780152 0.981227541971725 miRanda -0.228687536162075 0.00680091668391328 NA NA NA hsa-miR-139-5p SPATA5L1 -0.0625698939687087 0.914810329989088 0.148928093509348 0.652222100862292 miRanda -0.10418493844943 0.0018753441879598 NA NA NA hsa-miR-15b-5p SPHK2 0.251826642099145 0.790709218602499 -0.00196005164537461 0.996451472089075 mirMAP -0.145973908724666 0.000880039844800107 NA NA NA hsa-miR-107 SPRED1 -0.289737369453023 0.769655185893943 0.122957509326979 0.803851034166272 miRanda -0.118093961765081 0.0125580787222769 NA NA NA hsa-miR-15b-5p SPRED1 0.251826642099145 0.790709218602499 0.122957509326979 0.803851034166272 miRNATAP -0.166756378183416 0.000621309059337457 NA NA NA hsa-miR-148a-3p SPRY2 -0.324144803192141 0.746264759480212 -0.152531017422285 0.767354048564953 miRNAWalker2_validate -0.257518358867859 0.00215867572203667 NA NA NA hsa-miR-27a-3p SPRY2 0.309634509674364 0.703724209648479 -0.152531017422285 0.767354048564953 miRNAWalker2_validate;miRTarBase;miRNATAP -0.266966136912299 0.00382810614337747 20638779 By using a reporter-screening assay we discovered that the 3'UTR of Sprouty2 Spry2 carried a putative miR-27a binding site; Furthermore the Spry2 protein which has a low expression level in pancreatic adenocarcinoma was upregulated by transfection with a miR-27a inhibitor; The data reported here are the first to indicate that miR-27a plays an oncogenic role by targeting Spry2 and modulating the malignant biological behavior of pancreatic cancer cells malignant trasformation pancreatic cancer hsa-miR-15b-5p SPRYD3 0.251826642099145 0.790709218602499 0.294858019012453 0.568274429995135 MirTarget;miRNATAP -0.126477617447356 0.00110579165334713 NA NA NA hsa-miR-15b-5p SRC 0.251826642099145 0.790709218602499 -0.194254099489145 0.717069892382555 mirMAP -0.13838291634916 0.00849320285701445 NA NA NA hsa-miR-15b-5p SRCIN1 0.251826642099145 0.790709218602499 -0.545648932282877 0.265036057143992 mirMAP -0.354053412952948 0.0169412638244726 NA NA NA hsa-miR-363-3p SRL -0.186046567396088 0.728622856049059 0.581666925890669 0.105149389394778 mirMAP -0.10945776040442 0.0320469898023863 NA NA NA hsa-miR-107 SRPX -0.289737369453023 0.769655185893943 0.213115937292645 0.585720307202405 miRanda -0.37583278592853 3.93138987266804e-05 NA NA NA hsa-miR-107 SSTR1 -0.289737369453023 0.769655185893943 -0.362278070346641 0.428090859867161 miRanda -0.384102321807902 0.0016750938600533 NA NA NA hsa-miR-150-5p SSTR3 -0.00683324482969283 0.994067057151257 -0.810089083686777 0.146949257131576 mirMAP -0.217439467574994 0.00234122683092669 NA NA NA hsa-miR-27a-3p SSTR3 0.309634509674364 0.703724209648479 -0.810089083686777 0.146949257131576 mirMAP -0.367054255136499 0.00514701027478781 NA NA NA hsa-miR-214-3p SSX2IP 0.0312810611346688 0.952640488671912 -0.0452206205633239 0.920463392921776 MirTarget -0.106090310997664 3.88587245206739e-06 NA NA NA hsa-miR-107 ST13 -0.289737369453023 0.769655185893943 0.122640774158945 0.846360079181928 miRanda;miRNATAP -0.172302691653736 1.08450814338306e-06 NA NA NA hsa-miR-363-3p ST6GAL2 -0.186046567396088 0.728622856049059 0.978242272056301 0.0688473343748512 MirTarget;miRNATAP -0.191714388472952 0.00739975111686379 NA NA NA hsa-miR-107 ST6GALNAC3 -0.289737369453023 0.769655185893943 0.350832269722629 0.245440935757866 miRanda -0.163396524383979 0.0491300046206546 NA NA NA hsa-miR-27a-3p ST6GALNAC3 0.309634509674364 0.703724209648479 0.350832269722629 0.245440935757866 MirTarget -0.261889475435175 0.00026828675930838 NA NA NA hsa-miR-98-5p ST8SIA2 -0.0484028619275874 0.910781316485549 0.492411961105007 0.343994944731912 mirMAP -0.24052535404691 0.0181505994510849 NA NA NA hsa-miR-150-5p ST8SIA3 -0.00683324482969283 0.994067057151257 0.413336662572727 0.597168035578911 mirMAP -0.226081681276839 0.0121203064378479 NA NA NA hsa-miR-107 STAC -0.289737369453023 0.769655185893943 0.842823734321813 0.0936655940970346 miRanda -0.331163182851477 0.0273670982561272 NA NA NA hsa-miR-128-3p STK24 -0.0364518492233463 0.95841670253784 0.0425964726801906 0.950992537967364 MirTarget -0.129962718179589 0.00143221353847595 NA NA NA hsa-miR-15b-5p STK25 0.251826642099145 0.790709218602499 -0.0440739317877048 0.94312920220899 mirMAP -0.105720031675153 0.00175029683647674 NA NA NA hsa-miR-221-3p STK38L -0.261179092929062 0.744019631321393 0.22971715029466 0.680502373691106 MirTarget -0.151993863457492 0.000209188649560788 NA NA NA hsa-miR-222-3p STK38L -0.233673471709747 0.726651775432807 0.22971715029466 0.680502373691106 MirTarget -0.144470277488407 0.000387471451425708 NA NA NA hsa-miR-15b-5p STK40 0.251826642099145 0.790709218602499 -0.080139460670563 0.895993838658318 mirMAP -0.112753336573553 0.0285868839560017 NA NA NA hsa-miR-107 STMN2 -0.289737369453023 0.769655185893943 -0.249194632358188 0.703333680556331 miRanda -0.757138859802321 1.66517864111734e-06 NA NA NA hsa-miR-27a-3p STMN2 0.309634509674364 0.703724209648479 -0.249194632358188 0.703333680556331 miRNATAP -0.31981934066347 0.0223508300680308 NA NA NA hsa-miR-140-3p STRBP -0.105651799466207 0.9077781740714 0.0756679172913186 0.876796927946258 mirMAP -0.118394534751618 0.000176253917881932 NA NA NA hsa-miR-15b-5p STX1A 0.251826642099145 0.790709218602499 -0.0148647915230389 0.962426160138325 MirTarget -0.130137990374844 0.0107769002422479 NA NA NA hsa-miR-148a-3p STXBP1 -0.324144803192141 0.746264759480212 0.217059467031071 0.684589343227409 MirTarget -0.127748892814266 0.00110266618432247 NA NA NA hsa-miR-107 SUN2 -0.289737369453023 0.769655185893943 -0.0510341489137325 0.928062906786894 miRanda;miRNATAP -0.215448474568583 3.28100607677142e-05 NA NA NA hsa-miR-15b-5p SUPT3H 0.251826642099145 0.790709218602499 0.166889300321837 0.576308644615075 miRNAWalker2_validate -0.23543646112929 3.18032729017695e-05 NA NA NA hsa-miR-221-3p SUSD5 -0.261179092929062 0.744019631321393 -0.0420397937225279 0.891897159288725 miRNATAP -0.146946032336892 0.0206193088010605 NA NA NA hsa-miR-222-3p SUSD5 -0.233673471709747 0.726651775432807 -0.0420397937225279 0.891897159288725 miRNATAP -0.168088132384665 0.0075175140427915 NA NA NA hsa-miR-222-3p SV2A -0.233673471709747 0.726651775432807 0.0240248027077454 0.95210803409728 miRNAWalker2_validate -0.202399889884245 0.00446290134207727 NA NA NA hsa-miR-221-3p SVIP -0.261179092929062 0.744019631321393 -0.067019771442844 0.866183692691572 MirTarget -0.117661846124318 0.00395731188603821 NA NA NA hsa-miR-222-3p SVIP -0.233673471709747 0.726651775432807 -0.067019771442844 0.866183692691572 MirTarget -0.10495945568955 0.00967604982782453 NA NA NA hsa-miR-107 SYN2 -0.289737369453023 0.769655185893943 0.72714266057588 0.138080519498641 PITA;miRanda -0.289275298944318 0.0482511273774399 NA NA NA hsa-miR-15b-5p SYS1 0.251826642099145 0.790709218602499 0.163812412974545 0.753699839382929 MirTarget -0.13693877757074 0.000113075342446493 NA NA NA hsa-miR-22-3p SYT13 0.0468440219945929 0.967778504781139 -0.997651837798931 0.0654304331964072 MirTarget -0.338638562445918 0.00187793106996169 NA NA NA hsa-miR-140-3p TADA3 -0.105651799466207 0.9077781740714 0.276416517457551 0.665415332912267 miRNATAP -0.104114633100298 0.00122393246536179 NA NA NA hsa-miR-140-3p TAF2 -0.105651799466207 0.9077781740714 -0.0856192068455179 0.872814896690292 miRNATAP -0.108912135492718 0.00244961361319608 NA NA NA hsa-miR-139-5p TAF4B -0.0625698939687087 0.914810329989088 0.00389452570436832 0.991726959970854 miRanda -0.11008059518502 0.0309150656223534 NA NA NA hsa-miR-128-3p TAGLN -0.0364518492233463 0.95841670253784 0.997827025417021 0.190207406284929 miRNAWalker2_validate -0.308385458495059 0.00574575236771438 NA NA NA hsa-miR-107 TAL1 -0.289737369453023 0.769655185893943 -0.184039467903688 0.466470270206865 miRanda -0.205689211850199 0.00426938313308384 NA NA NA hsa-miR-15b-5p TAL1 0.251826642099145 0.790709218602499 -0.184039467903688 0.466470270206865 mirMAP -0.222918939712038 0.00274651331021345 NA NA NA hsa-miR-107 TAX1BP3 -0.289737369453023 0.769655185893943 -0.0571247207043006 0.928195926755751 miRanda -0.127963987245438 0.00474482690672056 NA NA NA hsa-miR-107 TBC1D13 -0.289737369453023 0.769655185893943 -0.0974357815321332 0.839851571620022 miRanda -0.108561143141656 0.00583257849669473 NA NA NA hsa-miR-15b-5p TBC1D13 0.251826642099145 0.790709218602499 -0.0974357815321332 0.839851571620022 MirTarget -0.103875367868 0.0108707443834051 NA NA NA hsa-miR-15b-5p TBC1D16 0.251826642099145 0.790709218602499 -0.463553514372146 0.277755749489003 MirTarget -0.178470172483482 0.00139370196460638 NA NA NA hsa-miR-107 TBC1D22A -0.289737369453023 0.769655185893943 0.134802414803678 0.757392133441859 miRanda -0.140433921782806 0.00031711265635646 NA NA NA hsa-miR-221-3p TBC1D24 -0.261179092929062 0.744019631321393 -0.107580416768721 0.788029258398955 mirMAP -0.218379951505083 1.36975797685655e-06 NA NA NA hsa-miR-222-3p TBC1D24 -0.233673471709747 0.726651775432807 -0.107580416768721 0.788029258398955 mirMAP -0.223339889913057 6.2092577074056e-07 NA NA NA hsa-miR-363-3p TBC1D24 -0.186046567396088 0.728622856049059 -0.107580416768721 0.788029258398955 mirMAP -0.104248591360022 0.000182287017308451 NA NA NA hsa-miR-27a-3p TBKBP1 0.309634509674364 0.703724209648479 -0.253779449183232 0.513141488182722 miRNATAP -0.121893757541277 0.0132375103583885 NA NA NA hsa-miR-98-5p TBKBP1 -0.0484028619275874 0.910781316485549 -0.253779449183232 0.513141488182722 MirTarget -0.168278917751602 4.95566707023797e-06 NA NA NA hsa-miR-15b-5p TBP 0.251826642099145 0.790709218602499 0.0240545192161061 0.948626276922458 MirTarget;miRNATAP -0.150084575039038 0.000104620457240841 NA NA NA hsa-miR-140-3p TCEA1 -0.105651799466207 0.9077781740714 -0.0321392826075737 0.9519614659549 MirTarget -0.118383746987478 0.000286577149659912 NA NA NA hsa-miR-22-3p TCEAL1 0.0468440219945929 0.967778504781139 0.0575213883378725 0.883812788871275 miRNAWalker2_validate;miRTarBase -0.139556325471307 5.46840949616891e-06 NA NA NA hsa-miR-107 TEF -0.289737369453023 0.769655185893943 -0.0675569807781331 0.875863926219485 mirMAP -0.199090940711487 0.000150305254729714 NA NA NA hsa-miR-27a-3p TET1 0.309634509674364 0.703724209648479 -0.0402960153837664 0.899827297880249 MirTarget -0.21865042404919 0.000867213635902811 NA NA NA hsa-miR-150-5p TGDS -0.00683324482969283 0.994067057151257 0.125100022922929 0.735461548207356 MirTarget -0.10300316688046 6.99412928928952e-07 NA NA NA hsa-miR-148a-3p TGIF2 -0.324144803192141 0.746264759480212 0.0237844750121701 0.967098478906165 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.103151833313873 0.00467588439947331 26638007 Down Regulation of miR 148a Promotes Metastasis by DNA Methylation and is Associated with Prognosis of Skin Cancer by Targeting TGIF2; The purpose of this study was to investigate the methylation status of miR-148a and its effects on the metastasis and prognosis of skin cancer as well as the interaction with TGIF2 gene; Luciferase reporter assay found that TGIF2 gene was a target gene and its expression was suppressed by miR-148a in skin cancer; CONCLUSIONS Taken together the expression of miR-148a was regulated by DNA methylation and targeted by TGIF2 metastasis;worse prognosis sarcoma hsa-miR-15b-5p THRA 0.251826642099145 0.790709218602499 -0.0207553900614785 0.967087576514824 miRNAWalker2_validate -0.137513119226872 0.0106962519521043 NA NA NA hsa-miR-27a-3p TIA1 0.309634509674364 0.703724209648479 -0.157008823042438 0.778990769960707 miRNATAP -0.130420448597275 0.000180650929668782 NA NA NA hsa-miR-139-5p TIAM2 -0.0625698939687087 0.914810329989088 -0.0229489514098309 0.942347420290614 miRanda -0.123150987357481 0.043367209740252 NA NA NA hsa-miR-660-5p TIMP3 -0.561687438133488 0.138270972367544 1.06975193073475 0.149989388698928 miRNATAP -0.28338523480551 4.33501695274483e-05 NA NA NA hsa-miR-15b-5p TLL1 0.251826642099145 0.790709218602499 0.309018979240895 0.545921599719278 miRNATAP -0.350151699162044 0.025754066118922 NA NA NA hsa-miR-128-3p TM4SF1 -0.0364518492233463 0.95841670253784 -0.0820718634976156 0.916781847907386 miRNAWalker2_validate -0.197203168604647 0.0230167148468009 NA NA NA hsa-miR-107 TMEM100 -0.289737369453023 0.769655185893943 0.495535461682809 0.457476870691068 miRanda -0.432748040002823 0.0256855165357337 NA NA NA hsa-miR-15b-5p TMEM100 0.251826642099145 0.790709218602499 0.495535461682809 0.457476870691068 MirTarget -0.591713366004596 0.00310238220629212 NA NA NA hsa-miR-150-5p TMEM108 -0.00683324482969283 0.994067057151257 0.131469366547538 0.76621738360944 MirTarget -0.123320292267155 0.0299052467952595 NA NA NA hsa-miR-197-3p TMEM120B 0.0240027695773914 0.981971058073739 -0.262167035576774 0.570219584061826 mirMAP -0.125514507103151 0.00684987938109266 NA NA NA hsa-miR-197-3p TMEM129 0.0240027695773914 0.981971058073739 0.069555103885345 0.895145250242225 miRNATAP -0.120309807802225 0.0211493161413807 NA NA NA hsa-miR-15b-5p TMEM130 0.251826642099145 0.790709218602499 0.629647070600561 0.169575109538357 mirMAP -0.460681674447719 0.000274048820878601 NA NA NA hsa-miR-150-5p TMEM132B -0.00683324482969283 0.994067057151257 -0.109537687118984 0.831840360812673 mirMAP -0.225276345531644 0.00170619550467815 NA NA NA hsa-miR-221-3p TMEM132B -0.261179092929062 0.744019631321393 -0.109537687118984 0.831840360812673 miRNAWalker2_validate -0.371242569854709 0.00175664134268799 NA NA NA hsa-miR-107 TMEM143 -0.289737369453023 0.769655185893943 -0.0760239801811755 0.81088683621981 miRanda -0.111441662196624 0.0148977118625035 NA NA NA hsa-miR-381-3p TMEM14C 0.269633663970002 0.562625029053898 0.133399066454686 0.829924171103182 MirTarget -0.138422345640014 2.46295869871273e-06 NA NA NA hsa-miR-22-3p TMEM155 0.0468440219945929 0.967778504781139 0.119838378084 0.786499074825218 MirTarget -0.279643570185876 0.00214483328258017 NA NA NA hsa-miR-27a-3p TMEM170B 0.309634509674364 0.703724209648479 -0.0100574758794614 0.975416324554827 miRNAWalker2_validate;MirTarget;miRNATAP -0.136226980948027 0.0017560889688463 NA NA NA hsa-miR-221-3p TMEM183A -0.261179092929062 0.744019631321393 0.0804674839053039 0.884013757053671 miRNAWalker2_validate -0.105441587310156 0.000610909942444742 NA NA NA hsa-miR-15b-5p TMEM198 0.251826642099145 0.790709218602499 0.0174318102775228 0.957818422237259 MirTarget -0.32815052011214 0.000163868995269292 NA NA NA hsa-miR-107 TMEM200A -0.289737369453023 0.769655185893943 0.465556179027795 0.212307261822615 miRanda -0.246775336853897 0.00670599977270861 NA NA NA hsa-miR-107 TMEM200B -0.289737369453023 0.769655185893943 -0.19024674498223 0.619531518636094 miRanda -0.331482079654863 0.00190206474238785 NA NA NA hsa-miR-107 TMEM204 -0.289737369453023 0.769655185893943 -0.0662137731686343 0.818757741159862 miRanda -0.244953482964148 2.68578357423308e-06 NA NA NA hsa-miR-127-3p TMEM27 0.231539840651733 0.822108193638849 0.0749896175653263 0.793064099756029 miRanda -0.152351877710525 0.00243585275648542 NA NA NA hsa-miR-98-5p TMEM45A -0.0484028619275874 0.910781316485549 0.161610266940888 0.697903007874834 miRNAWalker2_validate -0.168472971306859 0.00166934082747917 NA NA NA hsa-miR-221-3p TMEM56 -0.261179092929062 0.744019631321393 0.0036729800327393 0.992641575791848 mirMAP -0.177672198939652 0.0117695872266808 NA NA NA hsa-miR-139-5p TMEM68 -0.0625698939687087 0.914810329989088 0.0807876813238737 0.855570576202211 miRanda -0.105346864685216 0.00282063764666919 NA NA NA hsa-miR-127-3p TMOD1 0.231539840651733 0.822108193638849 0.381621851956994 0.565752800293319 miRanda -0.232909043708021 9.4709246372581e-05 NA NA NA hsa-miR-214-3p TMPRSS6 0.0312810611346688 0.952640488671912 -0.743097025413063 0.225222630341586 MirTarget -0.325212121811295 0.00103105030153664 NA NA NA hsa-miR-22-3p TMSB15B 0.0468440219945929 0.967778504781139 -0.56272692642928 0.161491437086946 MirTarget -0.354955263632488 0.000109650093763054 NA NA NA hsa-miR-27a-3p TMTC4 0.309634509674364 0.703724209648479 -0.149033403401955 0.761009839662486 MirTarget -0.118516483962212 0.00608819935940793 NA NA NA hsa-miR-139-5p TNFSF10 -0.0625698939687087 0.914810329989088 -0.199509460716673 0.77958190246055 miRanda -0.209661974968205 0.0159374737274873 NA NA NA hsa-miR-150-5p TNNI1 -0.00683324482969283 0.994067057151257 -0.212983430781827 0.566415468673695 mirMAP -0.218154905156732 5.82392293652961e-06 NA NA NA hsa-miR-214-3p TNNI1 0.0312810611346688 0.952640488671912 -0.212983430781827 0.566415468673695 mirMAP -0.109992781486758 0.0466883584147196 NA NA NA hsa-miR-148a-3p TNRC6C -0.324144803192141 0.746264759480212 -0.134000207956508 0.780052304855693 MirTarget;miRNATAP -0.113441214182673 0.0498542446416197 NA NA NA hsa-miR-15b-5p TOM1L2 0.251826642099145 0.790709218602499 -0.0981479526981506 0.842393354245454 mirMAP -0.106716698993049 0.0220311626661852 NA NA NA hsa-miR-221-3p TOX -0.261179092929062 0.744019631321393 0.137205334580283 0.765617454626825 MirTarget;miRNATAP -0.200080441653313 0.0360254014278339 NA NA NA hsa-miR-222-3p TOX -0.233673471709747 0.726651775432807 0.137205334580283 0.765617454626825 MirTarget;miRNATAP -0.194169536682037 0.0403201812130837 NA NA NA hsa-miR-107 TOX3 -0.289737369453023 0.769655185893943 -0.452475137758743 0.566719290713149 miRanda -0.841252159522854 0.000275670761381235 NA NA NA hsa-miR-22-3p TP73 0.0468440219945929 0.967778504781139 -0.344008159401897 0.412099831484199 mirMAP -0.312057040050556 0.0007192821797829 NA NA NA hsa-miR-107 TPM1 -0.289737369453023 0.769655185893943 0.360725453308555 0.566732511981325 PITA;miRanda -0.171794605278954 0.000702170009887133 NA NA NA hsa-miR-150-5p TPPP -0.00683324482969283 0.994067057151257 -0.427319842741888 0.328546375694931 mirMAP -0.192985890456036 0.000110469357511995 NA NA NA hsa-miR-214-3p TPPP 0.0312810611346688 0.952640488671912 -0.427319842741888 0.328546375694931 MirTarget -0.143355115281518 0.011837673724967 NA NA NA hsa-miR-15b-5p TPPP3 0.251826642099145 0.790709218602499 0.554995852636311 0.281321606493371 MirTarget;miRNATAP -0.464226846574161 8.27241606780802e-05 NA NA NA hsa-miR-214-3p TPPP3 0.0312810611346688 0.952640488671912 0.554995852636311 0.281321606493371 mirMAP -0.165237406915171 0.00754692961963128 NA NA NA hsa-miR-660-5p TRAM1L1 -0.561687438133488 0.138270972367544 -0.0279947673698322 0.938467850530622 MirTarget -0.140181960781931 0.0054458544678906 NA NA NA hsa-miR-197-3p TRAP1 0.0240027695773914 0.981971058073739 -0.0638748503438986 0.9196438159383 miRNAWalker2_validate -0.107007447737117 0.0218163878936225 NA NA NA hsa-miR-363-3p TRHDE -0.186046567396088 0.728622856049059 -0.503591479868391 0.503735138690962 MirTarget -0.462344149906924 1.41737242323792e-05 NA NA NA hsa-miR-139-5p TRIB2 -0.0625698939687087 0.914810329989088 -0.102338105476567 0.854624378266175 miRanda -0.132920149670936 0.0300890686439299 NA NA NA hsa-miR-128-3p TRIL -0.0364518492233463 0.95841670253784 0.0497405381840634 0.911129653245057 MirTarget -0.198386382366554 0.0290084447819276 NA NA NA hsa-miR-27a-3p TRIL 0.309634509674364 0.703724209648479 0.0497405381840634 0.911129653245057 MirTarget -0.24239324698574 0.00136139144828037 NA NA NA hsa-miR-22-3p TRIM13 0.0468440219945929 0.967778504781139 0.262542294186431 0.543661979211902 MirTarget -0.112757313383984 2.89174152457273e-05 NA NA NA hsa-miR-221-3p TRIM28 -0.261179092929062 0.744019631321393 -0.215733702038978 0.782259764856798 miRNAWalker2_validate -0.161138368105934 1.17773441923775e-05 NA NA NA hsa-miR-22-3p TRIM46 0.0468440219945929 0.967778504781139 -0.190343616955162 0.567899456007158 MirTarget -0.115349673456273 0.0482677342328698 NA NA NA hsa-miR-150-5p TRIM9 -0.00683324482969283 0.994067057151257 0.346366420432361 0.326595697296757 MirTarget -0.118078814506791 0.0162493371067559 NA NA NA hsa-miR-128-3p TRMT112 -0.0364518492233463 0.95841670253784 0.355893859634828 0.554020429315035 miRNAWalker2_validate -0.103542139281542 0.0395692790531055 NA NA NA hsa-miR-140-3p TRMT12 -0.105651799466207 0.9077781740714 0.0170292766100317 0.969459251263261 miRNATAP -0.237881014518689 3.75796188801902e-07 NA NA NA hsa-miR-107 TRPC1 -0.289737369453023 0.769655185893943 0.37368275609971 0.236767305992153 PITA;miRanda -0.263875846378283 0.000397705959589721 NA NA NA hsa-miR-22-3p TRUB1 0.0468440219945929 0.967778504781139 0.37968833000394 0.425876794753803 MirTarget;miRNATAP -0.110109165329879 0.000138639232247675 NA NA NA hsa-miR-221-3p TSN -0.261179092929062 0.744019631321393 0.0311637975762986 0.957135222937734 miRNAWalker2_validate -0.123526330743134 1.05323897555343e-06 NA NA NA hsa-miR-221-3p TSPAN13 -0.261179092929062 0.744019631321393 -0.300868373622002 0.54960062245422 MirTarget -0.215259674728405 0.000364620152444175 NA NA NA hsa-miR-222-3p TSPAN13 -0.233673471709747 0.726651775432807 -0.300868373622002 0.54960062245422 MirTarget -0.227998883599021 0.000138283952721022 NA NA NA hsa-miR-107 TSPAN18 -0.289737369453023 0.769655185893943 0.0471456072412799 0.917502737437692 miRanda -0.266739922421182 0.00325078381030981 NA NA NA hsa-miR-98-5p TSPAN18 -0.0484028619275874 0.910781316485549 0.0471456072412799 0.917502737437692 MirTarget -0.211852473083533 0.000393387228838743 NA NA NA hsa-miR-139-5p TSPAN3 -0.0625698939687087 0.914810329989088 0.245791583858663 0.74071464026602 MirTarget;PITA;miRanda;miRNATAP -0.116119508933106 0.00213750417821882 NA NA NA hsa-miR-15b-5p TSPAN3 0.251826642099145 0.790709218602499 0.245791583858663 0.74071464026602 miRNAWalker2_validate -0.100338857029098 0.0371194987960509 NA NA NA hsa-miR-107 TSPAN5 -0.289737369453023 0.769655185893943 -0.125280682002613 0.668611877673025 MirTarget;PITA;miRanda;miRNATAP -0.209178739247765 0.00847231943636534 NA NA NA hsa-miR-214-3p TTC39A 0.0312810611346688 0.952640488671912 -0.405615189375337 0.42122438442925 mirMAP -0.243581779011175 1.63799830972633e-05 NA NA NA hsa-miR-221-3p TUB -0.261179092929062 0.744019631321393 -0.374471694175891 0.361995538581085 miRNAWalker2_validate;MirTarget -0.174152807297352 0.00770504894655142 NA NA NA hsa-miR-222-3p TUB -0.233673471709747 0.726651775432807 -0.374471694175891 0.361995538581085 MirTarget -0.169565208360436 0.00893699335780295 NA NA NA hsa-miR-15b-5p TUBA1A 0.251826642099145 0.790709218602499 0.497451462097652 0.480638470292826 MirTarget;miRNATAP -0.284890970983786 0.000271829602292997 NA NA NA hsa-miR-221-3p TUBA1A -0.261179092929062 0.744019631321393 0.497451462097652 0.480638470292826 MirTarget -0.293451194373911 6.14796478982693e-07 NA NA NA hsa-miR-222-3p TUBA1A -0.233673471709747 0.726651775432807 0.497451462097652 0.480638470292826 MirTarget -0.264668069579491 6.31186788260664e-06 NA NA NA hsa-miR-107 TUBG2 -0.289737369453023 0.769655185893943 -0.0903098342594602 0.791396554219377 miRanda -0.104296496427315 0.0153367098797146 NA NA NA hsa-miR-128-3p TUSC5 -0.0364518492233463 0.95841670253784 1.3864873430346 0.0826715646957805 miRNAWalker2_validate -0.633690876833813 0.00574894075473634 NA NA NA hsa-miR-107 TWIST2 -0.289737369453023 0.769655185893943 0.231822075281934 0.601634751285074 miRanda -0.278512529063725 0.0334304353293569 NA NA NA hsa-miR-139-5p TXNL4B -0.0625698939687087 0.914810329989088 0.0158200231221626 0.968882682385132 miRanda -0.100302218979118 0.0146874648960887 NA NA NA hsa-miR-140-3p UBE2C -0.105651799466207 0.9077781740714 0.0935647546287539 0.871721449106861 miRNAWalker2_validate;miRNATAP -0.141043826755482 0.0369508058535519 NA NA NA hsa-miR-222-3p UBE2E3 -0.233673471709747 0.726651775432807 0.0526652875719975 0.923671851549949 miRNATAP -0.158277338908139 1.5176309130381e-07 NA NA NA hsa-miR-221-3p UBE2N -0.261179092929062 0.744019631321393 0.233034483101478 0.691060996748918 miRNAWalker2_validate -0.129364172091801 2.7414293653764e-05 NA NA NA hsa-miR-15b-5p UBFD1 0.251826642099145 0.790709218602499 -0.193230914246274 0.735114148719963 MirTarget;miRNATAP -0.137086419176319 0.000110538785224281 NA NA NA hsa-miR-107 UBL3 -0.289737369453023 0.769655185893943 0.248606683593827 0.618581932161698 PITA;miRanda;miRNATAP -0.145414936903315 0.00125608604602751 NA NA NA hsa-miR-107 UBL4A -0.289737369453023 0.769655185893943 -0.115764653952366 0.83373149002251 mirMAP -0.115368513854079 0.00920082852344027 NA NA NA hsa-miR-150-5p UBXN10 -0.00683324482969283 0.994067057151257 -0.0880880090323011 0.843058789010251 mirMAP -0.186467330328161 3.24238661254975e-06 NA NA NA hsa-miR-107 UNC119B -0.289737369453023 0.769655185893943 -0.255073342962268 0.619309549823191 MirTarget -0.179898098243373 0.000519073433001128 NA NA NA hsa-miR-15b-5p UNC119B 0.251826642099145 0.790709218602499 -0.255073342962268 0.619309549823191 MirTarget -0.229499282670735 1.68879627754677e-05 NA NA NA hsa-miR-22-3p UNC119B 0.0468440219945929 0.967778504781139 -0.255073342962268 0.619309549823191 MirTarget -0.231976303547296 2.73852140812855e-09 NA NA NA hsa-miR-27a-3p UNC119B 0.309634509674364 0.703724209648479 -0.255073342962268 0.619309549823191 mirMAP -0.251472669058326 1.54006047862445e-08 NA NA NA hsa-miR-15b-5p UNC80 0.251826642099145 0.790709218602499 -0.197447802223713 0.716260322984288 MirTarget;miRNATAP -0.700396429297842 4.05864214268584e-06 NA NA NA hsa-miR-27a-3p UNC80 0.309634509674364 0.703724209648479 -0.197447802223713 0.716260322984288 miRNATAP -0.512020390966268 6.95983858627218e-05 NA NA NA hsa-miR-15b-5p USP22 0.251826642099145 0.790709218602499 -0.184221328428914 0.785360558533857 mirMAP -0.11516856536231 0.00263017065672209 NA NA NA hsa-miR-15b-5p USP44 0.251826642099145 0.790709218602499 -0.00667178228043741 0.988552251377592 MirTarget -0.381987457276847 0.00774539705685155 NA NA NA hsa-miR-27a-3p USP51 0.309634509674364 0.703724209648479 -0.434533643728697 0.12323735758093 MirTarget;miRNATAP -0.283603604121282 4.72144671834067e-06 NA NA NA hsa-miR-107 USPL1 -0.289737369453023 0.769655185893943 -0.145684767595889 0.710110110206096 miRanda -0.111029209374844 0.00336512357620763 NA NA NA hsa-miR-140-3p UTP23 -0.105651799466207 0.9077781740714 0.0533937901912331 0.911359493356977 MirTarget -0.118097065273538 0.00514083024028675 NA NA NA hsa-miR-27a-3p VANGL2 0.309634509674364 0.703724209648479 -0.335803172975088 0.550688388728332 miRNATAP -0.128021232736324 0.0337939830851207 NA NA NA hsa-miR-107 VASP -0.289737369453023 0.769655185893943 0.119281349415242 0.840680336891893 miRanda -0.134166180505699 0.00175725367874436 NA NA NA hsa-miR-15b-5p VAT1 0.251826642099145 0.790709218602499 -0.0423137398494644 0.947381666005078 MirTarget;miRNATAP -0.162327415046613 0.000312967334504966 NA NA NA hsa-miR-107 VCAN -0.289737369453023 0.769655185893943 0.628346657399598 0.372826465442762 MirTarget;miRanda;miRNATAP -0.273647950880302 0.0424215723899891 NA NA NA hsa-miR-27a-3p VGF 0.309634509674364 0.703724209648479 -0.521834221163829 0.236881269265871 miRNATAP -0.317795587606075 0.00337904810822699 NA NA NA hsa-miR-15b-5p VPS33B 0.251826642099145 0.790709218602499 -0.145533794914663 0.676700992773092 MirTarget -0.126594309180328 0.000763833511871515 NA NA NA hsa-miR-98-5p VPS37B -0.0484028619275874 0.910781316485549 -0.25261967300478 0.631433703344324 mirMAP -0.129147454963126 3.76925740423484e-06 NA NA NA hsa-miR-15b-5p VPS4A 0.251826642099145 0.790709218602499 0.0536316931584118 0.921534502663911 MirTarget -0.111326605943189 0.000432651087804664 NA NA NA hsa-miR-15b-5p VWF 0.251826642099145 0.790709218602499 -0.420988262310166 0.480925419163038 mirMAP -0.223891329720188 0.00013408111214836 NA NA NA hsa-miR-22-3p WARS2 0.0468440219945929 0.967778504781139 -0.00471030719604126 0.991039475433535 MirTarget -0.138942763905713 1.80059737338802e-05 NA NA NA hsa-miR-22-3p WASF1 0.0468440219945929 0.967778504781139 0.321904576132275 0.468217747135163 MirTarget;miRNATAP -0.222873973715986 0.000105546604315301 NA NA NA hsa-miR-107 WASF3 -0.289737369453023 0.769655185893943 0.479341584458325 0.28478842084453 miRNATAP -0.287368061388297 0.000855438068879795 NA NA NA hsa-miR-221-3p WDR35 -0.261179092929062 0.744019631321393 0.147928942031917 0.722018779863624 MirTarget -0.22098143340468 1.82406739095417e-07 NA NA NA hsa-miR-222-3p WDR35 -0.233673471709747 0.726651775432807 0.147928942031917 0.722018779863624 MirTarget -0.232120913744504 3.04065222200144e-08 NA NA NA hsa-miR-27a-3p WDR35 0.309634509674364 0.703724209648479 0.147928942031917 0.722018779863624 MirTarget -0.131763019564288 0.00585686092103287 NA NA NA hsa-miR-140-3p WDR54 -0.105651799466207 0.9077781740714 0.50409357404074 0.245677056498739 miRNATAP -0.164650998815195 0.00662512843982551 NA NA NA hsa-miR-197-3p WDR6 0.0240027695773914 0.981971058073739 -0.27064989409961 0.6767963113116 miRNAWalker2_validate -0.120232177532212 0.0129023829722883 NA NA NA hsa-miR-221-3p WDR61 -0.261179092929062 0.744019631321393 0.102074286583017 0.827411439218937 miRNAWalker2_validate -0.107147647575167 0.00120246170154264 NA NA NA hsa-miR-214-3p WNK2 0.0312810611346688 0.952640488671912 -0.518842596009533 0.362307003157139 mirMAP -0.136581401016069 0.0244890431862789 NA NA NA hsa-miR-22-3p WNK2 0.0468440219945929 0.967778504781139 -0.518842596009533 0.362307003157139 mirMAP -0.230174916203687 0.00769953195455595 NA NA NA hsa-miR-222-3p WNK3 -0.233673471709747 0.726651775432807 -0.342494588983999 0.23478062644346 miRNATAP -0.142892191763526 0.0117311661396608 NA NA NA hsa-miR-107 WNT4 -0.289737369453023 0.769655185893943 0.177880468975003 0.686335530053085 PITA;miRNATAP -0.335860649413767 0.00436947352247334 NA NA NA hsa-miR-363-3p WNT9A -0.186046567396088 0.728622856049059 0.300264508185338 0.380417543798879 mirMAP -0.153783793288231 0.000947246444880775 NA NA NA hsa-miR-107 WTIP -0.289737369453023 0.769655185893943 -0.363367872238865 0.402870698746614 mirMAP -0.191736648051446 0.00289714109685374 NA NA NA hsa-miR-15b-5p WTIP 0.251826642099145 0.790709218602499 -0.363367872238865 0.402870698746614 mirMAP -0.194409320824277 0.00352918151377694 NA NA NA hsa-miR-140-3p XRCC5 -0.105651799466207 0.9077781740714 0.0882152000995138 0.905643165814152 MirTarget -0.114958160333596 7.25214211886595e-05 NA NA NA hsa-miR-148a-3p XYLT1 -0.324144803192141 0.746264759480212 0.227300345041255 0.584747858021969 mirMAP -0.206091566194021 0.0163916903959697 NA NA NA hsa-miR-128-3p YPEL3 -0.0364518492233463 0.95841670253784 0.324256878505045 0.587240846014544 MirTarget -0.162405783329563 0.00111144467217026 NA NA NA hsa-miR-221-3p YWHAE -0.261179092929062 0.744019631321393 -0.019943826544063 0.980118976253723 miRNAWalker2_validate -0.136078622661566 7.164812533928e-05 NA NA NA hsa-miR-27a-3p YWHAQ 0.309634509674364 0.703724209648479 0.248025307198988 0.749614689250482 MirTarget -0.144203173756859 8.4184486648493e-06 NA NA NA hsa-miR-140-3p YWHAZ -0.105651799466207 0.9077781740714 0.188455985676775 0.829924368207083 MirTarget;PITA;miRNATAP -0.108331424167537 0.00687508798589382 NA NA NA hsa-miR-107 ZBED4 -0.289737369453023 0.769655185893943 0.00813327164822653 0.985062955812975 miRanda -0.134559246558153 0.000946504881860886 NA NA NA hsa-miR-27a-3p ZBTB34 0.309634509674364 0.703724209648479 0.0114106620637942 0.976054394286673 MirTarget;miRNATAP -0.115629868416813 0.00181105875362378 NA NA NA hsa-miR-22-3p ZBTB39 0.0468440219945929 0.967778504781139 -0.163582166006159 0.689871027901515 MirTarget;miRNATAP -0.137355704231596 6.01182685340217e-05 NA NA NA hsa-miR-15b-5p ZBTB46 0.251826642099145 0.790709218602499 -0.363143239219536 0.46528615251256 MirTarget -0.147715737359592 0.0451715554129733 NA NA NA hsa-miR-98-5p ZBTB8B -0.0484028619275874 0.910781316485549 -0.292347035502569 0.518575141410114 MirTarget -0.21781442262593 0.0141796017422455 NA NA NA hsa-miR-15b-5p ZC3H12B 0.251826642099145 0.790709218602499 -0.361995898157424 0.218996761277024 miRNATAP -0.269062403624827 0.0025080741417027 NA NA NA hsa-miR-15b-5p ZC3H6 0.251826642099145 0.790709218602499 0.0664310878343275 0.862290500555547 miRNATAP -0.116155155821728 0.019327984486953 NA NA NA hsa-miR-107 ZC3H7B -0.289737369453023 0.769655185893943 -0.184910245519385 0.760413979417617 PITA;miRNATAP -0.137548287211035 0.000561000203282745 NA NA NA hsa-miR-15b-5p ZCCHC14 0.251826642099145 0.790709218602499 -0.053741999273627 0.913370762173496 miRNAWalker2_validate -0.194536395909898 0.000154488395125919 NA NA NA hsa-miR-150-5p ZDHHC22 -0.00683324482969283 0.994067057151257 0.132419503102911 0.828399656749994 MirTarget -0.240120646273261 0.00159870671357409 NA NA NA hsa-miR-15b-5p ZDHHC8 0.251826642099145 0.790709218602499 -0.357573835518696 0.491037220652071 mirMAP -0.120528540885123 0.0071252394530533 NA NA NA hsa-miR-128-3p ZEB1 -0.0364518492233463 0.95841670253784 0.174060806687355 0.660965127219402 MirTarget -0.148145642249719 0.0484532234152436 25921099 miR 128 modulates chemosensitivity and invasion of prostate cancer cells through targeting ZEB1 prostate cancer hsa-miR-15b-5p ZFHX3 0.251826642099145 0.790709218602499 -0.142657365419502 0.804712592221822 MirTarget;miRNATAP -0.202771041213214 0.000149012355864713 NA NA NA hsa-miR-98-5p ZFHX3 -0.0484028619275874 0.910781316485549 -0.142657365419502 0.804712592221822 miRNAWalker2_validate -0.144593173185827 2.2061113484391e-05 NA NA NA hsa-miR-107 ZFP28 -0.289737369453023 0.769655185893943 -0.179645714343375 0.573892458484186 miRanda -0.152236469747762 0.000826112892043404 NA NA NA hsa-miR-221-3p ZFP30 -0.261179092929062 0.744019631321393 -0.101958037580389 0.757912635004236 MirTarget -0.141773026205492 0.000482194159789366 NA NA NA hsa-miR-222-3p ZFP30 -0.233673471709747 0.726651775432807 -0.101958037580389 0.757912635004236 MirTarget -0.138075982291519 0.000614826239515209 NA NA NA hsa-miR-222-3p ZFYVE16 -0.233673471709747 0.726651775432807 0.0693272997858037 0.873079183336731 miRNAWalker2_validate;MirTarget -0.10591064288812 0.000112239187819279 NA NA NA hsa-miR-22-3p ZFYVE9 0.0468440219945929 0.967778504781139 -0.160956630328475 0.734837632244252 MirTarget;miRNATAP -0.101503141425988 0.00357217891540455 NA NA NA hsa-miR-660-5p ZHX2 -0.561687438133488 0.138270972367544 -0.0711119628838031 0.904233146117601 miRNATAP -0.111137781594 0.00706756959731525 NA NA NA hsa-miR-15b-5p ZKSCAN1 0.251826642099145 0.790709218602499 -0.121348754645731 0.813844705222115 MirTarget;miRNATAP -0.132540726909147 0.00301086443780066 NA NA NA hsa-miR-15b-5p ZKSCAN2 0.251826642099145 0.790709218602499 -0.0662994595729716 0.839631344096541 miRNATAP -0.26762523761814 9.03949907992505e-07 NA NA NA hsa-miR-27a-3p ZKSCAN2 0.309634509674364 0.703724209648479 -0.0662994595729716 0.839631344096541 MirTarget;miRNATAP -0.13659360856057 0.00334444741509095 NA NA NA hsa-miR-15b-5p ZMIZ1 0.251826642099145 0.790709218602499 -0.324984978920388 0.643326015977664 mirMAP -0.117595999623936 0.044926413020511 NA NA NA hsa-miR-140-3p ZMYM3 -0.105651799466207 0.9077781740714 -0.190016685953795 0.760001693031918 PITA -0.10623474716025 0.00154329182507572 NA NA NA hsa-miR-140-3p ZNF226 -0.105651799466207 0.9077781740714 -0.0694838208185926 0.836934545600267 miRNATAP -0.103432502817957 0.0257271232713731 NA NA NA hsa-miR-27a-3p ZNF329 0.309634509674364 0.703724209648479 -0.152487186391725 0.677687958890644 miRNATAP -0.130111798910533 0.000293467438336562 NA NA NA hsa-miR-128-3p ZNF34 -0.0364518492233463 0.95841670253784 -0.061187548230055 0.857976811756129 MirTarget -0.181088715963716 0.000799215077179787 NA NA NA hsa-miR-15b-5p ZNF346 0.251826642099145 0.790709218602499 0.00222459661969943 0.995217966941568 MirTarget -0.106491256694446 0.00825913281404265 NA NA NA hsa-miR-221-3p ZNF35 -0.261179092929062 0.744019631321393 -0.147138721044233 0.641516982915154 miRNAWalker2_validate -0.141413046695134 7.00337972035458e-07 NA NA NA hsa-miR-15b-5p ZNF362 0.251826642099145 0.790709218602499 -0.130498260842374 0.818096137664879 MirTarget;miRNATAP -0.147022929721132 0.000520595654746325 NA NA NA hsa-miR-15b-5p ZNF423 0.251826642099145 0.790709218602499 -0.516217270328072 0.316006276961565 miRNATAP -0.555582335047975 2.75746125325482e-06 NA NA NA hsa-miR-660-5p ZNF423 -0.561687438133488 0.138270972367544 -0.516217270328072 0.316006276961565 mirMAP -0.162471230549028 0.0255977494903126 NA NA NA hsa-miR-150-5p ZNF474 -0.00683324482969283 0.994067057151257 0.0728479621534679 0.860881483641885 miRNATAP -0.206844977752837 0.000287997233099266 NA NA NA hsa-miR-139-5p ZNF493 -0.0625698939687087 0.914810329989088 -0.163705873013241 0.659115422678931 miRanda -0.116957325651717 0.0190426102031214 NA NA NA hsa-miR-150-5p ZNF497 -0.00683324482969283 0.994067057151257 -0.286690880356528 0.354397160401612 mirMAP -0.110407157094013 2.94494355108328e-05 NA NA NA hsa-miR-15b-5p ZNF516 0.251826642099145 0.790709218602499 -0.470735455819248 0.27234943977937 mirMAP -0.310519164852193 1.41504548968231e-05 NA NA NA hsa-miR-27a-3p ZNF516 0.309634509674364 0.703724209648479 -0.470735455819248 0.27234943977937 miRNATAP -0.170275689830132 0.00515287190516381 NA NA NA hsa-miR-107 ZNF526 -0.289737369453023 0.769655185893943 -0.146781809798395 0.724854271085581 miRanda -0.109518326463619 0.00680504659688886 NA NA NA hsa-miR-107 ZNF548 -0.289737369453023 0.769655185893943 -0.177788657191938 0.618757892054964 miRanda -0.12523154548983 0.00665769797830509 NA NA NA hsa-miR-27a-3p ZNF551 0.309634509674364 0.703724209648479 -0.16534888704788 0.612686772608162 miRNATAP -0.159375027891737 0.00062821786027445 NA NA NA hsa-miR-221-3p ZNF571 -0.261179092929062 0.744019631321393 0.0497049032203134 0.848396869591575 miRNAWalker2_validate -0.118044678096474 0.00140020885114666 NA NA NA hsa-miR-139-5p ZNF572 -0.0625698939687087 0.914810329989088 -0.26020482735682 0.414262119903553 miRanda -0.20602632870199 9.92505787261402e-06 NA NA NA hsa-miR-107 ZNF582 -0.289737369453023 0.769655185893943 -0.196399106982681 0.431515528668 miRanda -0.160003976076588 0.0172181800411512 NA NA NA hsa-miR-107 ZNF586 -0.289737369453023 0.769655185893943 0.116010952283571 0.748982901937019 miRanda -0.181741392971122 0.00314572973099908 NA NA NA hsa-miR-107 ZNF606 -0.289737369453023 0.769655185893943 -0.316700326216714 0.421136942847005 MirTarget;miRanda -0.135160081599711 0.00706415562126044 NA NA NA hsa-miR-221-3p ZNF615 -0.261179092929062 0.744019631321393 -0.190081725102292 0.568922799331231 MirTarget -0.128023044267788 0.000698754311188927 NA NA NA hsa-miR-222-3p ZNF615 -0.233673471709747 0.726651775432807 -0.190081725102292 0.568922799331231 MirTarget -0.145060358352778 0.000102933410421809 NA NA NA hsa-miR-148a-3p ZNF618 -0.324144803192141 0.746264759480212 -0.228170793453136 0.681019696295386 miRNATAP -0.119182834639632 0.0015437769851201 NA NA NA hsa-miR-27a-3p ZNF620 0.309634509674364 0.703724209648479 -0.231633792805832 0.333314454766449 miRNATAP -0.101512960995742 0.0168817692521744 NA NA NA hsa-miR-150-5p ZNF625 -0.00683324482969283 0.994067057151257 -0.147746665810466 0.567169604897836 MirTarget -0.138104873254005 1.12834218235469e-05 NA NA NA hsa-miR-15b-5p ZNF629 0.251826642099145 0.790709218602499 -0.0571001080673312 0.915144368514333 miRNATAP -0.109740229862676 0.00709794820934456 NA NA NA hsa-miR-139-5p ZNF649 -0.0625698939687087 0.914810329989088 -0.373262166208389 0.360089836968903 miRanda -0.127425723345727 0.0046562629244197 NA NA NA hsa-miR-148a-3p ZNF665 -0.324144803192141 0.746264759480212 -0.341961699914061 0.0953075560421861 MirTarget -0.100828271734996 0.0226886221877474 NA NA NA hsa-miR-222-3p ZNF670 -0.233673471709747 0.726651775432807 -0.0263697859161081 0.915187056498908 MirTarget -0.161943499883303 2.76079872624483e-05 NA NA NA hsa-miR-140-3p ZNF677 -0.105651799466207 0.9077781740714 -0.0721312232159022 0.797589719352189 miRNATAP -0.130125689993841 0.04580415383857 NA NA NA hsa-miR-15b-5p ZNF697 0.251826642099145 0.790709218602499 -0.214799172094718 0.467404565876675 miRNATAP -0.267998444709203 3.13311306252704e-05 NA NA NA hsa-miR-222-3p ZNF708 -0.233673471709747 0.726651775432807 -0.14711225703798 0.638757303296248 miRNAWalker2_validate -0.155817001775589 6.69323539367133e-05 NA NA NA hsa-miR-150-5p ZNF711 -0.00683324482969283 0.994067057151257 -0.514937480773065 0.206818328957412 MirTarget -0.133649071820439 0.00748769435785501 NA NA NA hsa-miR-222-3p ZNF714 -0.233673471709747 0.726651775432807 -0.387983613882369 0.354260530373851 miRNAWalker2_validate -0.15313831122813 0.00432546178709457 NA NA NA hsa-miR-140-3p ZNF768 -0.105651799466207 0.9077781740714 -0.0769612496588907 0.889494562283885 miRNATAP -0.1140247755252 0.000167579323105299 NA NA NA hsa-miR-140-3p ZNF772 -0.105651799466207 0.9077781740714 -0.186151174166256 0.641668520513098 MirTarget -0.219175047633655 0.000822371707557344 NA NA NA hsa-miR-27a-3p ZNF780B 0.309634509674364 0.703724209648479 -0.172233406638922 0.633340872368802 MirTarget -0.14656965233442 0.00361072844124561 NA NA NA hsa-miR-139-5p ZNF792 -0.0625698939687087 0.914810329989088 -0.0191568196200911 0.949879224812413 MirTarget;miRanda -0.10006566936654 0.0194314180921909 NA NA NA hsa-miR-107 ZNF880 -0.289737369453023 0.769655185893943 -0.384322049393129 0.272857154493702 miRanda -0.246431932375037 0.000482886720170941 NA NA NA hsa-miR-221-3p ZNF93 -0.261179092929062 0.744019631321393 -0.108309927074221 0.764257061373746 MirTarget -0.188909267734001 8.71198929266268e-05 NA NA NA hsa-miR-222-3p ZNF93 -0.233673471709747 0.726651775432807 -0.108309927074221 0.764257061373746 MirTarget -0.187177092528949 8.90837949452485e-05 NA NA NA hsa-miR-107 ZSCAN22 -0.289737369453023 0.769655185893943 -0.162184979360733 0.578367908826222 miRanda -0.104418616594854 0.018139271690049 NA NA NA hsa-miR-15b-5p ZSWIM3 0.251826642099145 0.790709218602499 0.163008932312042 0.541898936609333 MirTarget;miRNATAP -0.102139703568939 0.00781097436271043 NA NA NA