miRNA	gene	miRNA_log2FC	miRNA_pvalue	gene_log2FC	gene_pvalue	interactions	correlation_beta	correlation_pvalue	PMID	evidence	outcome	cancer
hsa-miR-21-5p	AKT2	1.75445050487988	2.41825549682022e-23	-0.0135478038511252	0.922701697200587	miRNAWalker2_validate	-0.147206602823392	0.00352458167442573		NA	NA	NA
hsa-miR-29b-3p	AKT2	-0.230693226193598	0.367461626035234	-0.0135478038511252	0.922701697200587	MirTarget	-0.141689777106604	0.000224365237662475	26512921;26564501;24076586	MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3;The expression of miR-29b was significantly upregualted by cisplatin treatmentwhile its target gene AKT2 was downregulated;Furthermore a feed-back loop comprising of c-Myc miR-29 family and Akt2 were found in myeloid leukemogenesis	;;	ovarian cancer;gastric cancer;acute myeloid leukemia
hsa-miR-106b-5p	AKT3	1.70863907461894	2.04074794107142e-08	-0.748577301508132	0.0693608036068007	miRNATAP	-0.368902671357459	6.63579377990938e-05		NA	NA	NA
hsa-miR-107	AKT3	0.904627575346218	4.67936495073904e-05	-0.748577301508132	0.0693608036068007	PITA;miRanda	-0.596025797372068	4.38261497597827e-06		NA	NA	NA
hsa-miR-15b-5p	AKT3	1.62046407540723	5.42152621571078e-09	-0.748577301508132	0.0693608036068007	miRNATAP	-0.359857777182961	0.000407223981183838		NA	NA	NA
hsa-miR-16-5p	AKT3	1.00515772948091	5.33912942007619e-06	-0.748577301508132	0.0693608036068007	miRNAWalker2_validate;miRTarBase;miRNATAP	-0.473860841884761	0.000305952592817196		NA	NA	NA
hsa-miR-17-3p	AKT3	1.31126744284937	3.24768335024185e-07	-0.748577301508132	0.0693608036068007	miRNATAP	-0.520864813647553	2.25932722443508e-06		NA	NA	NA
hsa-miR-17-5p	AKT3	1.65862087862483	8.45603406215941e-08	-0.748577301508132	0.0693608036068007	TargetScan;miRNATAP	-0.276276453758938	0.00270096970703173		NA	NA	NA
hsa-miR-29a-3p	AKT3	-0.113012156986374	0.615005009685815	-0.748577301508132	0.0693608036068007	miRNATAP	-0.408748871699734	0.00212322174807936		NA	NA	NA
hsa-miR-29b-3p	AKT3	-0.230693226193598	0.367461626035234	-0.748577301508132	0.0693608036068007	miRNATAP	-0.338134432146425	0.00361456599882575	26512921	MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3		ovarian cancer
hsa-miR-32-3p	AKT3	0.583525764322974	0.11837203008551	-0.748577301508132	0.0693608036068007	mirMAP	-0.324144417685552	0.000230218736536503		NA	NA	NA
hsa-miR-320b	AKT3	1.11183660885284	0.000497971211648503	-0.748577301508132	0.0693608036068007	PITA;miRanda;miRNATAP	-0.263235906209639	0.00390234919135454		NA	NA	NA
hsa-miR-335-3p	AKT3	2.5197689063267	2.20084506976733e-09	-0.748577301508132	0.0693608036068007	mirMAP	-0.224460236877792	0.000742588100170571		NA	NA	NA
hsa-miR-33a-3p	AKT3	0.347011402017138	0.321709379745392	-0.748577301508132	0.0693608036068007	mirMAP	-0.376513667394311	1.68302152281553e-05		NA	NA	NA
hsa-miR-362-3p	AKT3	-0.0349414695893027	0.913780708043777	-0.748577301508132	0.0693608036068007	miRanda	-0.37545416085904	3.60412362584734e-05		NA	NA	NA
hsa-miR-362-5p	AKT3	-0.354508685915981	0.354912078595613	-0.748577301508132	0.0693608036068007	PITA;TargetScan;miRNATAP	-0.231850776707854	0.00252522310690117		NA	NA	NA
hsa-miR-501-3p	AKT3	0.731876211669996	0.0270421347018303	-0.748577301508132	0.0693608036068007	miRNATAP	-0.389710500003727	8.30408434984544e-06		NA	NA	NA
hsa-miR-502-3p	AKT3	-0.16442685491191	0.557471818466728	-0.748577301508132	0.0693608036068007	miRNATAP	-0.502835122914366	1.28261107693995e-06		NA	NA	NA
hsa-miR-505-3p	AKT3	0.82660100642669	0.00111666333288398	-0.748577301508132	0.0693608036068007	mirMAP	-0.351999859841566	0.0023495079245673	22051041	We also find that Akt3 correlate inversely with miR-505 modulates drug sensitivity in MCF7-ADR		breast cancer
hsa-miR-548v	AKT3	-0.156004387355895	0.708665170641638	-0.748577301508132	0.0693608036068007	miRNATAP	-0.26608196493585	0.000310856014668821		NA	NA	NA
hsa-miR-577	AKT3	0.911619788986754	0.2256062124148	-0.748577301508132	0.0693608036068007	mirMAP	-0.230357457399908	2.14832389488646e-09		NA	NA	NA
hsa-miR-616-5p	AKT3	0.834052908652744	0.0347835664029363	-0.748577301508132	0.0693608036068007	mirMAP	-0.265580906698402	0.000411824587413266		NA	NA	NA
hsa-miR-193b-3p	CASP9	0.281752012268679	0.451258902263119	-0.314756842171161	0.110040278687801	miRNAWalker2_validate	-0.173981251979618	2.15802379337291e-06		NA	NA	NA
hsa-miR-577	HSPB1	0.911619788986754	0.2256062124148	0.989970535491072	0.0619685121427502	PITA	-0.307423833021975	4.79163714338499e-10		NA	NA	NA
hsa-miR-149-5p	KDR	0.706277554734069	0.296848731347677	-0.700906973648848	0.0493591792780238	miRNATAP	-0.219672189869555	1.13049786050969e-09		NA	NA	NA
hsa-miR-23a-3p	KDR	1.10685926969665	3.16223452471768e-08	-0.700906973648848	0.0493591792780238	mirMAP	-0.553407435563254	7.15413862125e-06		NA	NA	NA
hsa-let-7a-3p	KRAS	0.503048155002889	0.0411145454335299	0.0440663168558286	0.888218969585117	mirMAP;miRNATAP	-0.274880026464494	0.00252165954052568	24727325;20603437;24890702;23324806;21994416;23167843;27620744;20177422;25183481;22584434;18922928	Association study of the let 7 miRNA complementary site variant in the 3' untranslated region of the KRAS gene in stage III colon cancer NCCTG N0147 Clinical Trial; A let-7 microRNA-complementary site LCS6 polymorphism in the 3' untranslated region of the KRAS gene has been shown to disrupt let-7 binding and upregulate KRAS expression;A let 7 microRNA binding site polymorphism in 3' untranslated region of KRAS gene predicts response in wild type KRAS patients with metastatic colorectal cancer treated with cetuximab monotherapy; A polymorphism in a let-7 microRNA complementary site lcs6 in the KRAS 3' untranslated region UTR is associated with an increased cancer risk in non-small-cell lung cancer and reduced overall survival OS in oral cancers; the presence of KRAS let-7 lcs6 polymorphism was evaluated in 130 mCRC patients who were enrolled in a phase II study of cetuximab monotherapy IMCL-0144; KRAS let-7 lcs6 polymorphism was found to be related to object response rate ORR in mCRC patients whose tumors had KRASwt;Let 7 microRNA binding site polymorphism in the 3'UTR of KRAS and colorectal cancer outcome: a systematic review and meta analysis; There is a small but growing body of literature regarding the predictive utility of a Let-7 microRNA-binding-site polymorphism in the 3'-untranslated region UTR of KRAS KRAS-LCS6 for colorectal cancer outcome although the results are conflicting; A PubMed search was conducted to identify all studies reporting on KRAS let-7 microRNA-binding site polymorphism LCS6; rs61764370 and colorectal cancer outcome;The LCS6 polymorphism in the binding site of let 7 microRNA to the KRAS 3' untranslated region: its role in the efficacy of anti EGFR based therapy in metastatic colorectal cancer patients; The lethal-7 let-7 family of microRNAs regulates KRAS activity; We studied the association of the KRAS let-7 LCS6 polymorphism with the response in 100 refractory mCRC patients treated with anti-EGFR antibodies; The KRAS let-7 LCS6 polymorphism was genotyped using the BioMark system in blood and tumor DNA samples; The KRAS let-7 LCS6 G-allele showed a statistically significant association with nonresponse to anti-EGFR-based treatment: 31.9% of patients with the T/T genotype presented a complete or a partial response versus no patients with T/G or G/G genotypes P=0.004;A let 7 microRNA SNP in the KRAS 3'UTR is prognostic in early stage colorectal cancer; Recently a SNP in a lethal-7 let-7 miRNA complementary site LCS6 in the KRAS 3'untranslated region was suggested to affect survival in metastatic CRC;Let 7 miRNA binding site polymorphism in the KRAS 3'UTR; colorectal cancer screening population prevalence and influence on clinical outcome in patients with metastatic colorectal cancer treated with 5 fluorouracil and oxaliplatin +/ cetuximab; Recent studies have reported associations between a variant allele in a let-7 microRNA complementary site LCS6 within the 3'untranslated region 3'UTR of KRAS rs61764370 and clinical outcome in metastatic colorectal cancer mCRC patients receiving cetuximab;A let 7 microRNA binding site polymorphism in the KRAS 3'UTR is associated with increased risk and reduced survival for gallbladder cancer in North Indian population; The let-7 microRNAs play a key role in regulating KRAS expression and a polymorphism in 3' untranslated region rs61764370 T/G of KRAS leads to its higher expression;Genetic modulation of the Let 7 microRNA binding to KRAS 3' untranslated region and survival of metastatic colorectal cancer patients treated with salvage cetuximab irinotecan; There is increasing evidence that the Let-7 microRNA miRNA exerts an effect as a tumor suppressor by targeting the KRAS mRNA; The Let-7 complementary site LCS6 T>G variant in the KRAS 3'-untranslated region weakens Let-7 binding;A let 7 microRNA binding site polymorphism in KRAS predicts improved outcome in patients with metastatic colorectal cancer treated with salvage cetuximab/panitumumab monotherapy;High let 7a microRNA levels in KRAS mutated colorectal carcinomas may rescue anti EGFR therapy effects in patients with chemotherapy refractory metastatic disease; Preclinical and experimental data in vivo indicate that Lethal-7 Let-7 microRNA downregulates KRAS with antitumor effects in the presence of activating KRAS mutations; In 59 patients harboring KRAS mutations Let-7a levels were analyzed for association with overall survival OS and progression-free survival PFS times; An exploratory subgroup analysis was performed using the rs61764370 LCS6 T>G polymorphism that experimentally impairs Let-7 binding to KRAS mRNA; In patients with KRAS mutations Let-7a analysis may serve to identify subgroups of patients who may still benefit from EGFR inhibition and this may open up new perspectives for alternative treatment strategies;A SNP in a let 7 microRNA complementary site in the KRAS 3' untranslated region increases non small cell lung cancer risk; The purpose of this study was to identify single nucleotide polymorphisms SNP that could modify let-7 binding and to assess the effect of such SNPs on target gene regulation and risk for non-small cell lung cancer NSCLC let-7 complementary sites LCS were sequenced in the KRAS 3' untranslated region from 74 NSCLC cases to identify mutations and SNPs that correlated with NSCLC; The LCS6 variant allele in a KRAS miRANA complementary site is significantly associated with increased risk for NSCLC among moderate smokers and represents a new paradigm for let-7 miRNAs in lung cancer susceptibility	staging;drug resistance;poor survival;;drug resistance;staging;poor survival;;poor survival;poor survival;;progression;poor survival;	colon cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;bladder cancer;colorectal cancer;colorectal cancer;colorectal cancer;lung squamous cell cancer
hsa-miR-143-3p	KRAS	-0.661937718854688	0.0483213962135842	0.0440663168558286	0.888218969585117	miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP	-0.177845989861529	0.00743791491988655	22804917;27725862;19137007;26581910;23173124;26824186;21197560	In KRAS mutated tumours increased miR-200b and decreased miR-143 expression were associated with a good PFS;The expression of miR-143 is often down-regulated and it might play an important role by targeting KRAS in colorectal cancer CRC; Dual-luciferase reporter assays were performed to validate whether KRAS was regulated by miR-143; Dual-luciferase assays indicated that KRAS was a direct target of miR-143 as subsequently demonstrated by qPCR and western blot analysis showing that infection of SW480 cells with Ad-ZD55-miR-143 resulted in the down-regulation of KRAS at both mRNA and protein levels;Role of miR 143 targeting KRAS in colorectal tumorigenesis; In particular among a panel of presumed targets generated by in silico analysis that may interact with these aberrantly expressed miRNAs KRAS oncogene has been further experimentally validated as the target of miR-143; First an inverse correlation between KRAS protein and miR-143 in vivo was found; Second KRAS expression in Lovo cells was significantly abolished by treatment with miR-143 mimic whereas miR-143 inhibitor increased KRAS protein level; Third luciferase reporter assay confirmed that miR-143 directly recognize the 3'-untranslated region of KRAS transcripts; Finally inhibition of KRAS expression by miR-143 inhibits constitutive phosphorylation of ERK1/2; Taken together the present study provides the first evidences that miR-143 is significant in suppressing colorectal cancer cell growth through inhibition of KRAS translation;MicroRNA 143 replenishment re sensitizes colorectal cancer cells harboring mutant but not wild type KRAS to paclitaxel treatment; Our results showed that miR-143 but not let-7b increased sensitization of KRAS mutant tumor cells to paclitaxel; Furthermore transfection of miR-143 but not let-7b mimic negatively regulated the expression of mutant but not wild-type KRAS; Combination of miR-143 mimic and paclitaxel induced the onset of apoptosis and reverted in vitro metastatic properties migration and invasion in KRAS mutant tumor cells; MiR-143 thus can be used as a chemosensitizer for the treatment of KRAS mutant tumors and warrants further investigations in in vitro and pre-clinical in vivo models;In turn the level of miR-143 in CRC cells decreasing the amount of MACC1 metastasis-associated in colon cancer-1 and oncogenic KRAS protein may be utilized as a prognostic marker;Stable miR-143 or miR-145 overexpression increased cell sensitivity to cetuximab resulting in a significant increase of cetuximab-mediated ADCC independently of KRAS status;miR 143 decreases prostate cancer cells proliferation and migration and enhances their sensitivity to docetaxel through suppression of KRAS; The expression level of miR-143 and its target gene KRAS were measured by realtime PCR and western blotting respectively; Our results revealed an inverse correlation of expression between miR-143 and KRAS protein in prostate cancer samples Pearson's correlation scatter plots: R = -0.707 P < 0.05; These findings suggest that miR-143 plays an important role in prostate cancer proliferation migration and chemosensitivity by suppressing KRAS and subsequent inactivation of MAPK pathway which provides a potential development of a new approach for the treatment of prostate cancer	;;tumorigenesis;;metastasis;;	colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colon cancer;prostate cancer
hsa-miR-193b-3p	KRAS	0.281752012268679	0.451258902263119	0.0440663168558286	0.888218969585117	miRNAWalker2_validate;MirTarget;miRNATAP	-0.202900424593209	0.000628014078688691	25905463	Deregulation of the MiR 193b KRAS Axis Contributes to Impaired Cell Growth in Pancreatic Cancer; Mechanistically KRAS was verified as a direct effector of miR-193b through which the AKT and ERK pathways were modulated and cell growth of PDAC cells was suppressed; Taken together our findings indicate that miR-193b-mediated deregulation of the KRAS axis is involved in pancreatic carcinogenesis and suggest that miR-193b could be a potentially effective target for PDAC therapy	tumorigenesis	pancreatic cancer
hsa-miR-224-3p	KRAS	1.52422171450716	0.00650463542340912	0.0440663168558286	0.888218969585117	mirMAP	-0.113759821037082	0.00837068880275088	25919696	MicroRNA 224 is associated with colorectal cancer progression and response to 5 fluorouracil based chemotherapy by KRAS dependent and independent mechanisms; MicroRNA-224 was differentially expressed in dysplastic colorectal disease and in isogeneic KRAS WT and mutant HCT116 cells; 5-FU chemosensitivity was significantly increased in miR-224 knockdown cells and in NIH3T3 cells expressing KRAS and BRAF mutant proteins	progression;drug resistance	colorectal cancer
hsa-miR-27b-3p	KRAS	0.0836323965901755	0.725273923274	0.0440663168558286	0.888218969585117	miRNATAP	-0.310127956853884	0.00104691607104432		NA	NA	NA
hsa-miR-101-3p	MAP2K1	-0.451263906815861	0.0283387250173031	0.350529324467741	0.0294686130211343	miRNAWalker2_validate	-0.210543062942234	0.00016389062492995		NA	NA	NA
hsa-miR-140-3p	MAP2K1	-0.296251775392129	0.127539826012144	0.350529324467741	0.0294686130211343	PITA	-0.25457882041555	1.7173921304805e-05		NA	NA	NA
hsa-miR-30c-5p	MAP2K1	-0.983130268805942	4.60419218706127e-05	0.350529324467741	0.0294686130211343	miRNAWalker2_validate	-0.187593003082029	5.3436762450792e-05		NA	NA	NA
hsa-miR-497-5p	MAP2K1	-0.801030912431774	0.00360386743876612	0.350529324467741	0.0294686130211343	miRNAWalker2_validate	-0.227085834893879	1.53919190373316e-08		NA	NA	NA
hsa-miR-126-5p	MAPK1	0.41765430251855	0.0753161203651532	-0.495098981122446	0.000571417199694919	mirMAP	-0.124608202204108	0.00475675613750838		NA	NA	NA
hsa-miR-140-3p	MAPK1	-0.296251775392129	0.127539826012144	-0.495098981122446	0.000571417199694919	PITA;miRNATAP	-0.145247944412064	0.0071251228758136		NA	NA	NA
hsa-miR-140-5p	MAPK1	0.208193069681326	0.303002433893804	-0.495098981122446	0.000571417199694919	miRanda	-0.168814127617461	0.00108046906118217		NA	NA	NA
hsa-miR-142-5p	MAPK1	1.55592486377018	6.69269968016779e-06	-0.495098981122446	0.000571417199694919	mirMAP	-0.122335014287939	1.92619380509704e-05		NA	NA	NA
hsa-miR-16-5p	MAPK1	1.00515772948091	5.33912942007619e-06	-0.495098981122446	0.000571417199694919	mirMAP	-0.128343010905179	0.00527308486345473		NA	NA	NA
hsa-miR-17-3p	MAPK1	1.31126744284937	3.24768335024185e-07	-0.495098981122446	0.000571417199694919	mirMAP	-0.106169760608366	0.00660645385547114		NA	NA	NA
hsa-miR-32-5p	MAPK1	0.415247682945382	0.106458022460373	-0.495098981122446	0.000571417199694919	mirMAP	-0.131661373347466	0.00100556712965003		NA	NA	NA
hsa-miR-320a	MAPK1	0.593888711838028	0.011897419390526	-0.495098981122446	0.000571417199694919	miRNAWalker2_validate;PITA;miRanda;miRNATAP	-0.124406693534882	0.00441330639927605		NA	NA	NA
hsa-miR-320b	MAPK1	1.11183660885284	0.000497971211648503	-0.495098981122446	0.000571417199694919	PITA;miRanda;miRNATAP	-0.118699294587812	0.000165603061513233		NA	NA	NA
hsa-miR-3614-3p	MAPK1	0.816988052098069	0.0143572924352078	-0.495098981122446	0.000571417199694919	mirMAP	-0.143042145876837	4.60745685333775e-06		NA	NA	NA
hsa-miR-361-3p	MAPK11	-0.126462931388735	0.566052688733137	-0.0718085853119947	0.830244671743565	mirMAP	-0.410420544598358	0.000168711320979975		NA	NA	NA
hsa-miR-103a-3p	NFAT5	0.840525139266028	5.83536475789158e-07	-0.0439355230583596	0.821582424796684	MirTarget	-0.255677804435568	0.00180291148235757		NA	NA	NA
hsa-miR-106b-5p	NFAT5	1.70863907461894	2.04074794107142e-08	-0.0439355230583596	0.821582424796684	MirTarget;miRNATAP	-0.161502292855746	0.000196506958270122		NA	NA	NA
hsa-miR-107	NFAT5	0.904627575346218	4.67936495073904e-05	-0.0439355230583596	0.821582424796684	MirTarget	-0.252442934044272	3.51847609026088e-05		NA	NA	NA
hsa-miR-148b-3p	NFAT5	0.295175884456199	0.17466422420702	-0.0439355230583596	0.821582424796684	miRNATAP	-0.260868207331971	4.18262214647347e-05		NA	NA	NA
hsa-miR-15b-3p	NFAT5	1.75738933306437	3.00554466232543e-08	-0.0439355230583596	0.821582424796684	mirMAP	-0.151504301973042	0.000280003150010012		NA	NA	NA
hsa-miR-15b-5p	NFAT5	1.62046407540723	5.42152621571078e-09	-0.0439355230583596	0.821582424796684	MirTarget	-0.155699757933455	0.00110546144197527		NA	NA	NA
hsa-miR-16-5p	NFAT5	1.00515772948091	5.33912942007619e-06	-0.0439355230583596	0.821582424796684	MirTarget	-0.185760783635526	0.00261203093918314		NA	NA	NA
hsa-miR-17-3p	NFAT5	1.31126744284937	3.24768335024185e-07	-0.0439355230583596	0.821582424796684	mirMAP	-0.192806475428848	0.000214985099259549		NA	NA	NA
hsa-miR-212-3p	NFAT5	0.960352937108106	0.00133449812322732	-0.0439355230583596	0.821582424796684	miRNATAP	-0.130100453396972	0.00453588235199981		NA	NA	NA
hsa-miR-24-3p	NFAT5	1.08578167539644	6.18549359075268e-07	-0.0439355230583596	0.821582424796684	miRNAWalker2_validate;miRNATAP	-0.184879068779719	0.00300617137195091		NA	NA	NA
hsa-miR-26b-3p	NFAT5	-0.0103961389461977	0.965770899625511	-0.0439355230583596	0.821582424796684	MirTarget;miRNATAP	-0.159455437554443	0.00570044197068339		NA	NA	NA
hsa-miR-32-5p	NFAT5	0.415247682945382	0.106458022460373	-0.0439355230583596	0.821582424796684	miRNATAP	-0.175202820898956	0.00112897748338262		NA	NA	NA
hsa-miR-320b	NFAT5	1.11183660885284	0.000497971211648503	-0.0439355230583596	0.821582424796684	mirMAP	-0.148455016371518	0.000470770281328749		NA	NA	NA
hsa-miR-330-3p	NFAT5	0.798460296022179	0.00746538156533435	-0.0439355230583596	0.821582424796684	mirMAP	-0.136215005171204	0.00306088384546863		NA	NA	NA
hsa-miR-33a-3p	NFAT5	0.347011402017138	0.321709379745392	-0.0439355230583596	0.821582424796684	mirMAP	-0.123931110033162	0.00278044814546085		NA	NA	NA
hsa-miR-33a-5p	NFAT5	0.407757858040717	0.321429014317207	-0.0439355230583596	0.821582424796684	MirTarget	-0.110888537621685	0.000879876898759067		NA	NA	NA
hsa-miR-340-5p	NFAT5	-0.164941927483643	0.529910509321278	-0.0439355230583596	0.821582424796684	MirTarget	-0.140678078773507	0.00802416038720252		NA	NA	NA
hsa-miR-424-3p	NFAT5	0.860888512744971	0.0234638352065231	-0.0439355230583596	0.821582424796684	miRNATAP	-0.135945800768731	0.000366649362631004		NA	NA	NA
hsa-miR-652-3p	NFAT5	1.02742852909286	0.000337974815149397	-0.0439355230583596	0.821582424796684	miRNAWalker2_validate	-0.141604959101737	0.00292258471248678		NA	NA	NA
hsa-miR-421	NFATC1	1.80720854070385	1.59709651202848e-07	-0.64759351504023	0.0529720238730398	miRanda	-0.2242554426875	0.000797844089394371		NA	NA	NA
hsa-miR-127-3p	NFATC2	0.211466568760589	0.46101284760949	-1.59961056631546	0.00281133641536435	miRanda	-0.440934200254586	0.00108125584988915		NA	NA	NA
hsa-miR-16-2-3p	NFATC2	1.8048179609245	2.83095715136409e-09	-1.59961056631546	0.00281133641536435	mirMAP	-0.41125270241114	0.000715298865948725		NA	NA	NA
hsa-miR-182-5p	NFATC2	0.887369486030646	0.0310640781418789	-1.59961056631546	0.00281133641536435	mirMAP	-0.567269109312586	2.24367951120668e-10		NA	NA	NA
hsa-miR-185-5p	NFATC2	1.14351510556643	1.07346945085714e-08	-1.59961056631546	0.00281133641536435	MirTarget	-0.499817944481714	0.00828802674325368		NA	NA	NA
hsa-miR-193b-5p	NFATC2	0.609581100028941	0.13923921336815	-1.59961056631546	0.00281133641536435	MirTarget	-0.680714524641957	6.25001943324036e-15		NA	NA	NA
hsa-miR-214-3p	NFATC2	1.01201534142544	0.00625092909225755	-1.59961056631546	0.00281133641536435	MirTarget;miRNATAP	-0.346814100487716	0.000754388476626183		NA	NA	NA
hsa-miR-218-5p	NFATC2	-0.987730614742492	0.0108295837207062	-1.59961056631546	0.00281133641536435	MirTarget	-0.282440161682966	0.00423199266169878		NA	NA	NA
hsa-miR-2355-3p	NFATC2	0.982963823342009	0.0229275810851348	-1.59961056631546	0.00281133641536435	mirMAP	-0.453847272998389	2.46446985195066e-07		NA	NA	NA
hsa-miR-2355-5p	NFATC2	0.594869787574182	0.120591076715177	-1.59961056631546	0.00281133641536435	MirTarget	-0.532848310106599	4.91423365542074e-08		NA	NA	NA
hsa-miR-24-3p	NFATC2	1.08578167539644	6.18549359075268e-07	-1.59961056631546	0.00281133641536435	MirTarget	-1.45254338985393	6.04651769391668e-20		NA	NA	NA
hsa-miR-27b-5p	NFATC2	0.680479953627235	0.0149700717026754	-1.59961056631546	0.00281133641536435	mirMAP	-0.42316502419689	0.00212327014131092		NA	NA	NA
hsa-miR-31-3p	NFATC2	0.474904754927656	0.506866261575484	-1.59961056631546	0.00281133641536435	MirTarget	-0.195566940204306	0.000270542724131413		NA	NA	NA
hsa-miR-33a-3p	NFATC2	0.347011402017138	0.321709379745392	-1.59961056631546	0.00281133641536435	mirMAP	-0.338506549372764	0.00353062499167457		NA	NA	NA
hsa-miR-452-5p	NFATC2	2.08756506185889	0.000258095769002813	-1.59961056631546	0.00281133641536435	MirTarget;miRNATAP	-0.5820965937005	9.37316214675739e-23		NA	NA	NA
hsa-miR-493-5p	NFATC2	0.962900723235399	0.00324541076496571	-1.59961056631546	0.00281133641536435	miRNATAP	-0.394683188595673	0.000708478667902983		NA	NA	NA
hsa-miR-9-5p	NFATC2	-0.195328736653048	0.761470692992178	-1.59961056631546	0.00281133641536435	MirTarget	-0.266371368646787	5.74817715985005e-06		NA	NA	NA
hsa-miR-30d-5p	NFATC3	-0.5492586056147	0.0140125082460125	0.283220117561481	0.0706943874963898	MirTarget;miRNATAP	-0.145740591292083	0.00355289056151992		NA	NA	NA
hsa-miR-362-3p	NFATC3	-0.0349414695893027	0.913780708043777	0.283220117561481	0.0706943874963898	miRanda	-0.126142417412468	0.000239581745736623		NA	NA	NA
hsa-miR-1254	NFATC4	0.941374574140312	0.0605480748500796	-0.980763910174937	0.0029209022426907	MirTarget	-0.215727047297164	0.000122900719889012		NA	NA	NA
hsa-miR-130b-5p	NFATC4	0.701350393759937	0.0510142718395002	-0.980763910174937	0.0029209022426907	mirMAP	-0.201332024330862	0.00216102171564684		NA	NA	NA
hsa-miR-15b-3p	NFATC4	1.75738933306437	3.00554466232543e-08	-0.980763910174937	0.0029209022426907	mirMAP	-0.402069412766773	8.91984604542673e-09		NA	NA	NA
hsa-miR-185-3p	NFATC4	1.33711019171256	3.45756583967985e-05	-0.980763910174937	0.0029209022426907	MirTarget	-0.314816627269359	9.37036160600659e-06		NA	NA	NA
hsa-miR-29b-3p	NFATC4	-0.230693226193598	0.367461626035234	-0.980763910174937	0.0029209022426907	miRNATAP	-0.26970494128862	0.00391795610199839		NA	NA	NA
hsa-miR-320a	NFATC4	0.593888711838028	0.011897419390526	-0.980763910174937	0.0029209022426907	miRanda;mirMAP	-0.351342242860151	0.000468865306104097		NA	NA	NA
hsa-miR-320b	NFATC4	1.11183660885284	0.000497971211648503	-0.980763910174937	0.0029209022426907	miRanda;mirMAP	-0.332027993771327	4.22472900238734e-06		NA	NA	NA
hsa-miR-320c	NFATC4	0.455072851945474	0.240613785444485	-0.980763910174937	0.0029209022426907	miRanda;mirMAP	-0.234195633885622	0.00089352283684434		NA	NA	NA
hsa-miR-361-3p	NFATC4	-0.126462931388735	0.566052688733137	-0.980763910174937	0.0029209022426907	mirMAP	-0.336766197694243	0.00204561584110053		NA	NA	NA
hsa-miR-429	NFATC4	1.40182602301928	0.00900426780286475	-0.980763910174937	0.0029209022426907	miRNATAP	-0.207303237402496	1.27015716066244e-06		NA	NA	NA
hsa-miR-484	NFATC4	0.71327898984355	0.00233605130771196	-0.980763910174937	0.0029209022426907	MirTarget;miRNATAP	-0.492753812629456	6.90322701785734e-07		NA	NA	NA
hsa-miR-625-5p	NFATC4	0.537211086526376	0.203801009380384	-0.980763910174937	0.0029209022426907	mirMAP	-0.159316378849634	0.00460664291026236		NA	NA	NA
hsa-miR-629-3p	NFATC4	1.40326397107309	9.7803063526732e-05	-0.980763910174937	0.0029209022426907	mirMAP	-0.283244907446903	8.72915740660251e-06		NA	NA	NA
hsa-miR-940	NFATC4	1.64406174271686	0.000690854900107004	-0.980763910174937	0.0029209022426907	miRNATAP	-0.188985957537193	0.000863191691433627		NA	NA	NA
hsa-miR-542-3p	NOS3	0.757649022262991	0.00210575463285599	-0.498491172500839	0.181081624890022	miRanda	-0.306775573263927	0.00446104048890028		NA	NA	NA
hsa-let-7c-5p	NRAS	-0.503482361446512	0.206848395212976	0.606733058105388	0.0107700909176788	miRNAWalker2_validate;miRTarBase;MirTarget	-0.124225168269858	0.00351586115791848		NA	NA	NA
hsa-miR-145-5p	NRAS	-1.75133578902314	1.54965572197748e-05	0.606733058105388	0.0107700909176788	miRNAWalker2_validate;MirTarget;miRNATAP	-0.113590801226011	0.00562715254109734	26973415	miR-145 expression was significantly downregulated in colon cancer tissues with its expression in normal colonic tissues being 4-5-fold higher two sample t test P < 0.05 whereas N-ras expression showed the opposite trend		colon cancer
hsa-miR-26a-5p	NRAS	-0.384110714440647	0.0442498636014044	0.606733058105388	0.0107700909176788	mirMAP;miRNATAP	-0.253407088765911	0.00536728320880026	26458859	MiR 26a enhances the sensitivity of gastric cancer cells to cisplatin by targeting NRAS and E2F2; Our results suggest that miR-26a can improve the sensitivity of GC cells to cisplatin-based chemotherapies through targeting NRAS and E2F2 and provide the first evidence of the potential utility of miR-26a as a sensitizer in chemotherapy for GC		gastric cancer
hsa-miR-28-5p	NRAS	-0.238617853755144	0.167318538669818	0.606733058105388	0.0107700909176788	MirTarget;PITA;miRanda;miRNATAP	-0.309483366881585	0.00227879779800337		NA	NA	NA
hsa-miR-29c-3p	NRAS	-1.62454036584589	5.38376515586029e-07	0.606733058105388	0.0107700909176788	miRNATAP	-0.175997480071788	0.000530133170369644		NA	NA	NA
hsa-miR-126-5p	PIK3CA	0.41765430251855	0.0753161203651532	0.181162005416898	0.379919524282219	mirMAP	-0.230165325454576	0.000229328041159233		NA	NA	NA
hsa-miR-146a-5p	PIK3CA	1.82051649415508	2.03651725047679e-05	0.181162005416898	0.379919524282219	mirMAP	-0.130514283326015	8.03472410512393e-05		NA	NA	NA
hsa-miR-148a-5p	PIK3CA	-0.69329616490858	0.0793012233740369	0.181162005416898	0.379919524282219	mirMAP	-0.160710142606256	9.74691916818117e-06		NA	NA	NA
hsa-miR-148b-3p	PIK3CA	0.295175884456199	0.17466422420702	0.181162005416898	0.379919524282219	miRNAWalker2_validate	-0.270665697414514	6.25461929338548e-05		NA	NA	NA
hsa-miR-186-5p	PIK3CA	0.149964130725901	0.434709542998771	0.181162005416898	0.379919524282219	mirMAP	-0.283664174467296	0.000254482000083255		NA	NA	NA
hsa-miR-29b-1-5p	PIK3CA	0.606560155953522	0.116355599574769	0.181162005416898	0.379919524282219	mirMAP	-0.105962073023743	0.00514891759991948		NA	NA	NA
hsa-miR-320b	PIK3CA	1.11183660885284	0.000497971211648503	0.181162005416898	0.379919524282219	miRanda	-0.131928082159166	0.00355606170878243		NA	NA	NA
hsa-miR-335-5p	PIK3CA	1.59953351087307	5.56170899867314e-05	0.181162005416898	0.379919524282219	miRNAWalker2_validate	-0.142668444274705	6.55217134166698e-05		NA	NA	NA
hsa-miR-338-5p	PIK3CA	-1.19659203838734	0.0100316010080496	0.181162005416898	0.379919524282219	mirMAP	-0.128160056012068	3.12181075963217e-05		NA	NA	NA
hsa-miR-501-5p	PIK3CA	0.266919328110625	0.454779001968586	0.181162005416898	0.379919524282219	mirMAP	-0.184484665922465	4.78508048904086e-06		NA	NA	NA
hsa-miR-7-1-3p	PIK3CA	0.709309110750947	0.0412301737463194	0.181162005416898	0.379919524282219	mirMAP	-0.18347710340594	9.07765701687707e-06		NA	NA	NA
hsa-miR-130a-3p	PIK3CB	0.146223920674657	0.633739795905839	0.248944033508746	0.180378115579181	miRNATAP	-0.141347568269357	0.0010035949231668		NA	NA	NA
hsa-miR-1468-5p	PIK3CD	-1.88350218312373	3.31332405201189e-05	0.391814669139483	0.253077445924908	MirTarget	-0.217696918010317	3.06934786857079e-05		NA	NA	NA
hsa-miR-30b-3p	PIK3CD	-0.266398938200332	0.400847813143994	0.391814669139483	0.253077445924908	MirTarget	-0.431008741394064	8.57729594514163e-09		NA	NA	NA
hsa-miR-30b-5p	PIK3CD	-0.430720743745757	0.0593564057320791	0.391814669139483	0.253077445924908	MirTarget	-0.481822586915696	5.93876910377637e-06		NA	NA	NA
hsa-miR-30d-5p	PIK3CD	-0.5492586056147	0.0140125082460125	0.391814669139483	0.253077445924908	MirTarget;miRNATAP	-0.669349357920634	2.53796175626459e-10		NA	NA	NA
hsa-miR-616-5p	PIK3CD	0.834052908652744	0.0347835664029363	0.391814669139483	0.253077445924908	MirTarget	-0.171408745877689	0.0062816347712319		NA	NA	NA
hsa-miR-7-5p	PIK3CD	1.63575693499363	0.0124424214624534	0.391814669139483	0.253077445924908	miRTarBase;MirTarget;miRNATAP	-0.205801781586893	4.40558507915807e-08	22234835	We first screened and identified a novel miR-7 target phosphoinositide 3-kinase catalytic subunit delta PIK3CD; A correlation between miR-7 and PIK3CD expression was also confirmed in clinical samples of HCC; By targeting PIK3CD mTOR and p70S6K miR-7 efficiently regulates the PI3K/Akt pathway		liver cancer
hsa-miR-103a-3p	PIK3R1	0.840525139266028	5.83536475789158e-07	-1.09428616452248	2.46783518047221e-05	MirTarget;miRNATAP	-0.323457232113071	0.0039447769693221		NA	NA	NA
hsa-miR-106b-5p	PIK3R1	1.70863907461894	2.04074794107142e-08	-1.09428616452248	2.46783518047221e-05	MirTarget;miRNATAP	-0.253346436583178	1.72729352701852e-05		NA	NA	NA
hsa-miR-107	PIK3R1	0.904627575346218	4.67936495073904e-05	-1.09428616452248	2.46783518047221e-05	MirTarget;PITA;miRanda;miRNATAP	-0.238654922729134	0.0046938788179217		NA	NA	NA
hsa-miR-128-3p	PIK3R1	0.98280381420517	5.77641850797209e-05	-1.09428616452248	2.46783518047221e-05	MirTarget	-0.253825409257793	0.000861541031670611	25962360	miR 128 3p suppresses hepatocellular carcinoma proliferation by regulating PIK3R1 and is correlated with the prognosis of HCC patients; Mechanistically miR-128-3p was confirmed to regulate PIK3R1 p85α expression thereby suppressing phosphatidylinositol 3-kinase PI3K/AKT pathway activation using qRT-PCR and western blot analysis; Hence we conclude that miR-128-3p which is frequently downregulated in HCC inhibits HCC progression by regulating PIK3R1 and PI3K/AKT activation and is a prognostic marker for HCC patients	worse prognosis;progression	liver cancer
hsa-miR-144-3p	PIK3R1	-0.13309578176575	0.798245647923351	-1.09428616452248	2.46783518047221e-05	mirMAP	-0.138673461850839	0.000126186382128809		NA	NA	NA
hsa-miR-15b-5p	PIK3R1	1.62046407540723	5.42152621571078e-09	-1.09428616452248	2.46783518047221e-05	MirTarget	-0.323211150072369	4.46298725379362e-07		NA	NA	NA
hsa-miR-16-2-3p	PIK3R1	1.8048179609245	2.83095715136409e-09	-1.09428616452248	2.46783518047221e-05	MirTarget	-0.270383492169966	3.99207467881518e-06		NA	NA	NA
hsa-miR-16-5p	PIK3R1	1.00515772948091	5.33912942007619e-06	-1.09428616452248	2.46783518047221e-05	MirTarget	-0.405416526556489	9.69480909855754e-07		NA	NA	NA
hsa-miR-17-5p	PIK3R1	1.65862087862483	8.45603406215941e-08	-1.09428616452248	2.46783518047221e-05	MirTarget;TargetScan;miRNATAP	-0.192199170444737	0.00107429271534319		NA	NA	NA
hsa-miR-182-5p	PIK3R1	0.887369486030646	0.0310640781418789	-1.09428616452248	2.46783518047221e-05	miRNATAP	-0.160218491940506	0.000398426335382569		NA	NA	NA
hsa-miR-185-5p	PIK3R1	1.14351510556643	1.07346945085714e-08	-1.09428616452248	2.46783518047221e-05	miRNATAP	-0.41775889137189	4.21636400438791e-06		NA	NA	NA
hsa-miR-188-5p	PIK3R1	1.35426907033843	0.00038346077691455	-1.09428616452248	2.46783518047221e-05	MirTarget	-0.162900447887926	0.000775923703794411		NA	NA	NA
hsa-miR-200b-3p	PIK3R1	0.974577911407732	0.0595020056914543	-1.09428616452248	2.46783518047221e-05	mirMAP	-0.103803538669649	0.00409847558383849		NA	NA	NA
hsa-miR-200c-3p	PIK3R1	1.28185685499076	0.00369777635539177	-1.09428616452248	2.46783518047221e-05	mirMAP	-0.143316221972735	0.00063899158230993		NA	NA	NA
hsa-miR-20a-5p	PIK3R1	1.4503375861709	5.7813456424762e-07	-1.09428616452248	2.46783518047221e-05	MirTarget;miRNATAP	-0.175478538743826	0.0056099063555159		NA	NA	NA
hsa-miR-21-5p	PIK3R1	1.75445050487988	2.41825549682022e-23	-1.09428616452248	2.46783518047221e-05	miRNAWalker2_validate;MirTarget;miRNATAP	-0.306402457018565	0.00154965993784699	26676464	PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer	cell migration	breast cancer
hsa-miR-212-3p	PIK3R1	0.960352937108106	0.00133449812322732	-1.09428616452248	2.46783518047221e-05	MirTarget	-0.22956448368642	0.000224776230276284		NA	NA	NA
hsa-miR-22-5p	PIK3R1	0.804348748654247	0.000804065112767412	-1.09428616452248	2.46783518047221e-05	mirMAP	-0.271562984507077	0.000499671844853285		NA	NA	NA
hsa-miR-221-3p	PIK3R1	1.33496247538338	3.82022531235275e-07	-1.09428616452248	2.46783518047221e-05	MirTarget	-0.313499877783358	5.35467630228685e-06		NA	NA	NA
hsa-miR-222-3p	PIK3R1	1.39382731585819	9.98182478024671e-07	-1.09428616452248	2.46783518047221e-05	MirTarget	-0.284754511073413	7.61572703183408e-06		NA	NA	NA
hsa-miR-3065-5p	PIK3R1	-0.241623656423063	0.633116553078159	-1.09428616452248	2.46783518047221e-05	MirTarget;mirMAP;miRNATAP	-0.124182539774803	0.00105993614946939		NA	NA	NA
hsa-miR-32-3p	PIK3R1	0.583525764322974	0.11837203008551	-1.09428616452248	2.46783518047221e-05	mirMAP	-0.17265888879632	0.00228085828010069		NA	NA	NA
hsa-miR-320b	PIK3R1	1.11183660885284	0.000497971211648503	-1.09428616452248	2.46783518047221e-05	miRNATAP	-0.162259703959997	0.00544641812773208		NA	NA	NA
hsa-miR-324-3p	PIK3R1	1.04940352369965	0.000387716796520961	-1.09428616452248	2.46783518047221e-05	MirTarget;PITA;miRNATAP	-0.184232658949902	0.00347746569584922		NA	NA	NA
hsa-miR-330-3p	PIK3R1	0.798460296022179	0.00746538156533435	-1.09428616452248	2.46783518047221e-05	MirTarget;PITA;miRNATAP	-0.26440540068663	2.08637052595379e-05		NA	NA	NA
hsa-miR-335-3p	PIK3R1	2.5197689063267	2.20084506976733e-09	-1.09428616452248	2.46783518047221e-05	mirMAP	-0.148076206465714	0.000495756694433814		NA	NA	NA
hsa-miR-424-5p	PIK3R1	1.08509868581983	0.000420473853818268	-1.09428616452248	2.46783518047221e-05	MirTarget	-0.287369315123124	1.32105570633977e-06		NA	NA	NA
hsa-miR-429	PIK3R1	1.40182602301928	0.00900426780286475	-1.09428616452248	2.46783518047221e-05	mirMAP;miRNATAP	-0.126994249956039	0.00022771493817442		NA	NA	NA
hsa-miR-455-3p	PIK3R1	2.29532323519288	1.85675588946527e-07	-1.09428616452248	2.46783518047221e-05	MirTarget;PITA;miRNATAP	-0.181586331748295	8.05157474846207e-06		NA	NA	NA
hsa-miR-542-3p	PIK3R1	0.757649022262991	0.00210575463285599	-1.09428616452248	2.46783518047221e-05	MirTarget;PITA;miRanda	-0.239065351988831	0.0017318237826115		NA	NA	NA
hsa-miR-584-5p	PIK3R1	1.68234626630933	0.000166828539264215	-1.09428616452248	2.46783518047221e-05	mirMAP	-0.129450210806705	0.00170622715972499		NA	NA	NA
hsa-miR-590-3p	PIK3R1	1.11654983899947	0.000160782154924864	-1.09428616452248	2.46783518047221e-05	miRanda;mirMAP	-0.266046553887174	1.8351581859886e-05		NA	NA	NA
hsa-miR-590-5p	PIK3R1	1.04171442093217	0.000272475544954865	-1.09428616452248	2.46783518047221e-05	MirTarget;PITA;miRanda;miRNATAP	-0.297910761408884	3.33366270664506e-06		NA	NA	NA
hsa-miR-629-3p	PIK3R1	1.40326397107309	9.7803063526732e-05	-1.09428616452248	2.46783518047221e-05	MirTarget	-0.16619442916244	0.00118253063445621		NA	NA	NA
hsa-miR-96-5p	PIK3R1	1.14243043653372	0.00942969392739105	-1.09428616452248	2.46783518047221e-05	TargetScan;miRNATAP	-0.193630203103858	1.00718533638407e-05		NA	NA	NA
hsa-miR-30a-5p	PIK3R2	-1.71922855140016	3.20574349285256e-07	0.00922907299312037	0.961081205853821	miRNATAP	-0.137164224996737	0.000346855164996688		NA	NA	NA
hsa-miR-1271-5p	PIK3R3	1.15538250415776	0.00207865862606828	-0.662491536689023	0.0210304127874503	mirMAP	-0.197799197361284	0.00028487328401707		NA	NA	NA
hsa-miR-185-3p	PIK3R3	1.33711019171256	3.45756583967985e-05	-0.662491536689023	0.0210304127874503	MirTarget	-0.200301326896551	0.00130353125166929		NA	NA	NA
hsa-miR-511-5p	PIK3R3	0.542335183701817	0.127507740178883	-0.662491536689023	0.0210304127874503	MirTarget	-0.231823970894027	4.82261601939889e-05	25608840	MiR 511 inhibits growth and metastasis of human hepatocellular carcinoma cells by targeting PIK3R3; We further demonstrated that miR-511 suppressed HCC cell proliferation migration and invasion by repressing PIK3R3 expression	metastasis	liver cancer
hsa-miR-708-3p	PIK3R3	0.623782703831307	0.275355868302311	-0.662491536689023	0.0210304127874503	mirMAP	-0.147502347303041	2.93933869168246e-05		NA	NA	NA
hsa-miR-182-5p	PIK3R5	0.887369486030646	0.0310640781418789	-0.106061319644644	0.802628610118832	MirTarget	-0.363007599134275	3.56264538888151e-07		NA	NA	NA
hsa-miR-18a-3p	PIK3R5	2.35188582849667	1.39401350286321e-08	-0.106061319644644	0.802628610118832	MirTarget	-0.215221108190999	0.00210782353217643		NA	NA	NA
hsa-miR-142-5p	PLA2G12A	1.55592486377018	6.69269968016779e-06	-0.897976387208921	3.92439583608381e-08	mirMAP	-0.120071229648663	0.000364039582551817		NA	NA	NA
hsa-miR-16-2-3p	PLA2G12A	1.8048179609245	2.83095715136409e-09	-0.897976387208921	3.92439583608381e-08	mirMAP	-0.13547544045603	0.000324052648114578		NA	NA	NA
hsa-let-7g-5p	PLA2G3	0.325297685027927	0.241142963826631	1.08081143630036	0.274800614063828	MirTarget	-0.713843300957369	0.00535751699457478		NA	NA	NA
hsa-miR-338-3p	PLA2G3	-0.959276231066179	0.0191473351014091	1.08081143630036	0.274800614063828	MirTarget;miRanda;miRNATAP	-0.599759722990571	0.000430611134352631		NA	NA	NA
hsa-miR-592	PLA2G3	0.779567202789068	0.204498177014474	1.08081143630036	0.274800614063828	miRNATAP	-0.323513783396214	0.00859092346414437		NA	NA	NA
hsa-miR-128-3p	PLA2G5	0.98280381420517	5.77641850797209e-05	-1.41308234162024	0.0225473078256035	miRNAWalker2_validate	-0.905295305603834	2.75117618540628e-07		NA	NA	NA
hsa-miR-330-5p	PLA2G5	0.488365986827708	0.0512207630808233	-1.41308234162024	0.0225473078256035	miRanda	-0.926413267320503	1.02011927893847e-07		NA	NA	NA
hsa-miR-339-5p	PLA2G5	0.770566566962108	0.00816529093411862	-1.41308234162024	0.0225473078256035	miRanda	-0.723615809585887	1.23466479069586e-06		NA	NA	NA
hsa-miR-429	PLA2G5	1.40182602301928	0.00900426780286475	-1.41308234162024	0.0225473078256035	miRanda	-0.548400833208393	1.57333799329149e-12		NA	NA	NA
hsa-miR-589-3p	PLA2G5	1.01962606923682	0.00577853347252709	-1.41308234162024	0.0225473078256035	MirTarget	-0.574409018016161	8.84241947286267e-07		NA	NA	NA
hsa-miR-590-3p	PLA2G5	1.11654983899947	0.000160782154924864	-1.41308234162024	0.0225473078256035	miRanda;miRNATAP	-0.733311626897206	4.33156195650278e-07		NA	NA	NA
hsa-miR-590-5p	PLA2G5	1.04171442093217	0.000272475544954865	-1.41308234162024	0.0225473078256035	miRanda	-0.821191810458237	3.9237270066779e-08		NA	NA	NA
hsa-miR-200b-3p	PLCG1	0.974577911407732	0.0595020056914543	0.220650145027044	0.240784739884018	TargetScan	-0.152523804697572	5.66449876796049e-10		NA	NA	NA
hsa-miR-3065-3p	PLCG1	-1.03551124329864	0.0218397494946288	0.220650145027044	0.240784739884018	miRNATAP	-0.103906981778707	0.000353878093657446		NA	NA	NA
hsa-miR-429	PLCG1	1.40182602301928	0.00900426780286475	0.220650145027044	0.240784739884018	PITA;miRanda;miRNATAP	-0.140203562615716	3.32118673073251e-09		NA	NA	NA
hsa-miR-582-5p	PLCG1	-0.448820171762719	0.134615974001015	0.220650145027044	0.240784739884018	PITA;miRNATAP	-0.144938357620992	0.00109688062783437		NA	NA	NA
hsa-miR-335-5p	PLCG2	1.59953351087307	5.56170899867314e-05	0.0457293991289704	0.881449349859118	miRNAWalker2_validate	-0.148683931134901	0.00575362635056513		NA	NA	NA
hsa-miR-106b-5p	PPP3CA	1.70863907461894	2.04074794107142e-08	-0.311261735064956	0.0874904847441977	miRNATAP	-0.177382254092271	1.11662949783484e-05		NA	NA	NA
hsa-miR-142-5p	PPP3CA	1.55592486377018	6.69269968016779e-06	-0.311261735064956	0.0874904847441977	PITA;mirMAP;miRNATAP	-0.110997481793963	0.00234330425678312		NA	NA	NA
hsa-miR-340-5p	PPP3CA	-0.164941927483643	0.529910509321278	-0.311261735064956	0.0874904847441977	mirMAP	-0.181573032833897	0.000232248398119678		NA	NA	NA
hsa-miR-361-5p	PPP3CA	0.407725414130987	0.0181260969156347	-0.311261735064956	0.0874904847441977	miRanda	-0.225189217128007	0.0033708826866865		NA	NA	NA
hsa-miR-374b-3p	PPP3CA	0.999491658196932	0.00126937019814872	-0.311261735064956	0.0874904847441977	MirTarget	-0.164661177292416	0.000153667800685453		NA	NA	NA
hsa-miR-590-5p	PPP3CA	1.04171442093217	0.000272475544954865	-0.311261735064956	0.0874904847441977	PITA;miRanda;miRNATAP	-0.120747875637189	0.00696948367873323		NA	NA	NA
hsa-miR-940	PPP3CA	1.64406174271686	0.000690854900107004	-0.311261735064956	0.0874904847441977	miRNATAP	-0.111531019863646	0.000298626343209584		NA	NA	NA
hsa-miR-107	PPP3CB	0.904627575346218	4.67936495073904e-05	-0.544004942139345	9.04819078192179e-05	miRanda	-0.142015238506317	0.00140035242278882		NA	NA	NA
hsa-miR-15a-5p	PPP3CB	1.03783090449383	7.40334108980898e-07	-0.544004942139345	9.04819078192179e-05	miRNATAP	-0.163057694878539	0.000473345260508312		NA	NA	NA
hsa-miR-15b-5p	PPP3CB	1.62046407540723	5.42152621571078e-09	-0.544004942139345	9.04819078192179e-05	miRNATAP	-0.186954475055184	2.5872809097186e-08		NA	NA	NA
hsa-miR-16-5p	PPP3CB	1.00515772948091	5.33912942007619e-06	-0.544004942139345	9.04819078192179e-05	miRNATAP	-0.20524854257795	2.83538301027824e-06		NA	NA	NA
hsa-miR-20a-3p	PPP3CB	1.13957127410163	0.000451087640268489	-0.544004942139345	9.04819078192179e-05	miRNATAP	-0.125773580763174	2.60598588386373e-05		NA	NA	NA
hsa-miR-339-5p	PPP3CB	0.770566566962108	0.00816529093411862	-0.544004942139345	9.04819078192179e-05	miRanda	-0.140550747992229	3.00402583828723e-05		NA	NA	NA
hsa-miR-7-1-3p	PPP3CB	0.709309110750947	0.0412301737463194	-0.544004942139345	9.04819078192179e-05	mirMAP	-0.112769612670814	6.65442420729316e-05		NA	NA	NA
hsa-miR-101-3p	PPP3R1	-0.451263906815861	0.0283387250173031	0.365031614184003	0.00208633293716482	miRNATAP	-0.129816071813413	0.00164042594155264		NA	NA	NA
hsa-miR-26a-5p	PPP3R1	-0.384110714440647	0.0442498636014044	0.365031614184003	0.00208633293716482	MirTarget;miRNATAP	-0.142127049894375	0.00146987441972325		NA	NA	NA
hsa-miR-183-5p	PRKCA	1.65900927871187	0.000522025364980187	-0.524945602243661	0.156845722980603	miRNATAP	-0.31103089433757	3.16968192454963e-09		NA	NA	NA
hsa-miR-193b-3p	PRKCA	0.281752012268679	0.451258902263119	-0.524945602243661	0.156845722980603	miRNAWalker2_validate	-0.484019253003446	4.65153076194767e-13		NA	NA	NA
hsa-miR-193b-5p	PRKCA	0.609581100028941	0.13923921336815	-0.524945602243661	0.156845722980603	mirMAP	-0.433727503937308	7.91160654871288e-13		NA	NA	NA
hsa-miR-200c-3p	PRKCA	1.28185685499076	0.00369777635539177	-0.524945602243661	0.156845722980603	miRNATAP	-0.158267946470227	0.0075664310799573		NA	NA	NA
hsa-miR-214-3p	PRKCA	1.01201534142544	0.00625092909225755	-0.524945602243661	0.156845722980603	mirMAP	-0.229516662046359	0.00116026469450838		NA	NA	NA
hsa-miR-218-5p	PRKCA	-0.987730614742492	0.0108295837207062	-0.524945602243661	0.156845722980603	mirMAP	-0.340197633280215	2.69227593052796e-07		NA	NA	NA
hsa-miR-22-5p	PRKCA	0.804348748654247	0.000804065112767412	-0.524945602243661	0.156845722980603	mirMAP	-0.289814182834915	0.0085643888637562		NA	NA	NA
hsa-miR-224-5p	PRKCA	2.7648036144402	0.000111736336240167	-0.524945602243661	0.156845722980603	mirMAP	-0.266077095767105	2.93934461700145e-15		NA	NA	NA
hsa-miR-2355-3p	PRKCA	0.982963823342009	0.0229275810851348	-0.524945602243661	0.156845722980603	mirMAP	-0.192620283882863	0.00177074877059007		NA	NA	NA
hsa-miR-24-2-5p	PRKCA	1.24948624677556	6.95051249640114e-07	-0.524945602243661	0.156845722980603	miRNAWalker2_validate	-0.44305928315788	1.26846671995315e-05	22911661	Preferential star strand biogenesis of pre miR 24 2 targets PKC alpha and suppresses cell survival in MCF 7 breast cancer cells	poor survival	breast cancer
hsa-miR-3065-5p	PRKCA	-0.241623656423063	0.633116553078159	-0.524945602243661	0.156845722980603	mirMAP	-0.138739209322651	0.00952332540419745		NA	NA	NA
hsa-miR-30e-3p	PRKCA	-0.913131357083321	7.29096855615228e-06	-0.524945602243661	0.156845722980603	mirMAP	-0.480631092157774	0.000179519199509064		NA	NA	NA
hsa-miR-340-5p	PRKCA	-0.164941927483643	0.529910509321278	-0.524945602243661	0.156845722980603	mirMAP	-0.30203863377261	0.00294907401860914		NA	NA	NA
hsa-miR-369-3p	PRKCA	0.32261175629684	0.3589927609891	-0.524945602243661	0.156845722980603	PITA;miRNATAP	-0.329749662436249	8.7729830203155e-06		NA	NA	NA
hsa-miR-374a-3p	PRKCA	0.0420912023953779	0.851478041312794	-0.524945602243661	0.156845722980603	mirMAP	-0.476867699823759	5.6043349916606e-05		NA	NA	NA
hsa-miR-374a-5p	PRKCA	-0.116485410477589	0.554703396010082	-0.524945602243661	0.156845722980603	mirMAP	-0.356017213117889	0.00964742858084568		NA	NA	NA
hsa-miR-381-3p	PRKCA	-0.385137659444633	0.19550293487428	-0.524945602243661	0.156845722980603	mirMAP	-0.251195477739459	0.00489691969707007		NA	NA	NA
hsa-miR-452-5p	PRKCA	2.08756506185889	0.000258095769002813	-0.524945602243661	0.156845722980603	mirMAP	-0.362021740586027	3.81652270570704e-18		NA	NA	NA
hsa-miR-485-3p	PRKCA	0.402652239390796	0.291980476362068	-0.524945602243661	0.156845722980603	PITA	-0.187072641608852	0.00755799449285324		NA	NA	NA
hsa-miR-590-3p	PRKCA	1.11654983899947	0.000160782154924864	-0.524945602243661	0.156845722980603	PITA;miRanda;mirMAP;miRNATAP	-0.253263144251919	0.0041311394662334		NA	NA	NA
hsa-miR-654-3p	PRKCA	-0.180620884059292	0.603937505298333	-0.524945602243661	0.156845722980603	mirMAP	-0.244452048619274	0.00127970540235088		NA	NA	NA
hsa-miR-9-3p	PRKCA	0.330346058941473	0.541111939982661	-0.524945602243661	0.156845722980603	mirMAP	-0.16554523182915	0.00109100333735947		NA	NA	NA
hsa-miR-9-5p	PRKCA	-0.195328736653048	0.761470692992178	-0.524945602243661	0.156845722980603	miRNATAP	-0.159066735795387	8.70395397790985e-05		NA	NA	NA
hsa-miR-93-3p	PRKCA	1.88964231421793	1.80075645722786e-08	-0.524945602243661	0.156845722980603	mirMAP	-0.204378358847077	0.00717568024324572		NA	NA	NA
hsa-miR-944	PRKCA	3.33123095809751	0.0177835044930391	-0.524945602243661	0.156845722980603	PITA;miRNATAP	-0.18876945085729	3.75302733857894e-21		NA	NA	NA
hsa-miR-141-5p	PRKCB	2.07543489990205	6.42575039070838e-06	-1.4030462275744	0.00367216720425109	mirMAP	-0.395737238483437	3.03734398729028e-08		NA	NA	NA
hsa-miR-16-2-3p	PRKCB	1.8048179609245	2.83095715136409e-09	-1.4030462275744	0.00367216720425109	mirMAP	-0.394725287595774	0.000305348610545586		NA	NA	NA
hsa-miR-200b-3p	PRKCB	0.974577911407732	0.0595020056914543	-1.4030462275744	0.00367216720425109	MirTarget	-0.282755939415459	1.75770095316849e-05		NA	NA	NA
hsa-miR-200c-3p	PRKCB	1.28185685499076	0.00369777635539177	-1.4030462275744	0.00367216720425109	MirTarget;miRNATAP	-0.484133503530668	8.09834496190732e-11		NA	NA	NA
hsa-miR-23a-3p	PRKCB	1.10685926969665	3.16223452471768e-08	-1.4030462275744	0.00367216720425109	mirMAP	-0.683926072101064	5.15520137880557e-05		NA	NA	NA
hsa-miR-24-3p	PRKCB	1.08578167539644	6.18549359075268e-07	-1.4030462275744	0.00367216720425109	miRNATAP	-0.723177032098718	2.88589756557307e-06		NA	NA	NA
hsa-miR-27a-3p	PRKCB	1.29886998470345	2.68986118553486e-08	-1.4030462275744	0.00367216720425109	MirTarget;miRNATAP	-0.51359480289477	0.000369553651535914		NA	NA	NA
hsa-miR-335-3p	PRKCB	2.5197689063267	2.20084506976733e-09	-1.4030462275744	0.00367216720425109	mirMAP	-0.29799969660431	0.000138565873644795		NA	NA	NA
hsa-miR-429	PRKCB	1.40182602301928	0.00900426780286475	-1.4030462275744	0.00367216720425109	MirTarget;miRanda;miRNATAP	-0.304844311690637	1.18954411842667e-06		NA	NA	NA
hsa-miR-452-3p	PRKCB	2.2028815467959	0.00185370432491004	-1.4030462275744	0.00367216720425109	mirMAP	-0.17651507962963	0.00117496673508882		NA	NA	NA
hsa-miR-589-3p	PRKCB	1.01962606923682	0.00577853347252709	-1.4030462275744	0.00367216720425109	mirMAP	-0.261170452838673	0.00515336080055526		NA	NA	NA
hsa-miR-589-5p	PRKCB	0.702695092403762	0.00395772685954799	-1.4030462275744	0.00367216720425109	mirMAP	-0.370279961813979	0.00967226035852969		NA	NA	NA
hsa-miR-590-5p	PRKCB	1.04171442093217	0.000272475544954865	-1.4030462275744	0.00367216720425109	miRanda	-0.40560794652637	0.000708295993250929		NA	NA	NA
hsa-miR-616-5p	PRKCB	0.834052908652744	0.0347835664029363	-1.4030462275744	0.00367216720425109	mirMAP	-0.374505698749983	2.12152566695212e-05		NA	NA	NA
hsa-miR-9-3p	PRKCB	0.330346058941473	0.541111939982661	-1.4030462275744	0.00367216720425109	mirMAP	-0.172769921695024	0.00989297046602862		NA	NA	NA
hsa-miR-2355-5p	PRKCG	0.594869787574182	0.120591076715177	-0.106646796932468	0.91801459782895	MirTarget	-0.976109502699328	1.98177589887047e-07		NA	NA	NA
hsa-miR-101-3p	PTGS2	-0.451263906815861	0.0283387250173031	1.14368145058001	0.0493360092487668	miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP	-0.694219337523404	0.000687412348541482	26530100;26556718;21430074;24759835;24289600;23644120;24958470;26617722;19133256;24528073;25109742;23013439	Luciferase assay revealed that COX-2 was a direct target for miR-101-3p and overexpression of miR-101-3p decreased cellular COX-2 protein expression; Finally downregulation of miR-101-3p expression and upregulation of COX-2 was found in ESCC specimens from patients with smoking history; Taken together our findings revealed a new post-transcriptional mechanism by which CSE regulated COX-2 expression to favor cancer cell proliferation suggesting miR-101-3p as a potential biomarker and therapeutic target for smoke-related ESCC;Cyclooxygenase 2 a Potential Therapeutic Target Is Regulated by miR 101 in Esophageal Squamous Cell Carcinoma; This study investigated the effect of miR-101 on ESCC through modulating COX-2 expression in ESCC; The luciferase reporter assay was used to verify COX-2 as a direct target of miR-101; Furthermore COX-2 was shown to be a target of miR-101;Enforced expression of miR 101 inhibits prostate cancer cell growth by modulating the COX 2 pathway in vivo; In this study we investigated the mechanism of microRNA-101 miR-101-regulated COX-2 expression and the therapeutic potential of exogenous miR-101 for COX-2-associated cancer; We found that miR-101 inhibited COX-2 posttranscriptional expression by directly binding to the 3'-untranslated region 3'-UTR of COX-2 mRNA; In conclusion COX-2 is a direct target in miR-101 regulation of posttranscription; These data suggest that exogenous miR-101 may provide a new cancer therapy by directly inhibiting COX-2 expression;MiR-16 and miR-101 levels do not correlate with COX-2 mRNA and protein levels;The expression of COX-2 in Hela cell was also examined by immunohistochemical staining and the correlation with miR-101 expression was analysed; Thus reduced miR-101 expression could participate in the development of cervical cancer at least partly through loss of inhibition of target gene COX-2 which probably occurs in a relative late phase of carcinogenesis;Expressions of COX 2 PKC α and miR 101 in gastric cancer and their correlations; To investigate the expressions of miR-101 protein kinase C-α PKC-α and cyclooxygenase-2 COX-2 in gastric cancer GC tissue and their correlations; RT-qPCR was used to examine miR-101 expression and Western blotting employed to detect PKC-α and COX-2 expressions in 57 cases of gastric cancer tissues and paired normal gastric mucosal tissues; The gastric cancer tissues showed a significantly lower miR-101 expression Z=6.102 P<0.05 but significantly higher expressions of COX-2 Z=14.436 P<0.05 and PKC-α Z=6.955 P<0.05 than the normal gastric tissues; PKC-α expression was positively correlated r=0.531 P<0.05 and miR-101 expression negatively correlated r=-0.627 P<0.05 with COX-2 expression in gastric cancer tissues; miR-101 PKC-α and COX-2 all play a role in the tumorigenesis and progression of gastric cancer; miR-101 and PKC-α might be new potential therapeutic targets for inhibiting COX-2 in gastric cancer;Interestingly cyclooxygenase-2 inhibition by aspirin or celecoxib abrogated IL-1β-mediated repression of miR-101 and IL-1β-mediated activation of Lin28B along with their stimulatory effects on NSCLC cell proliferation and migration;Immunohistochemistry was performed to assess protein expression of the miR-101 target gene COX-2; Overexpression of miR-101 decreased expression of its target gene Cox-2 and inhibited proliferation and invasion and promoted apoptosis to suppress tumorigenicity;MiR 101 downregulation is involved in cyclooxygenase 2 overexpression in human colon cancer cells; In this paper we report the inverse correlation between COX-2 and miR-101 expression in colon cancer cell lines and we demonstrated in vitro the direct inhibition of COX-2 mRNA translation mediated by miR-101; These findings provide a novel molecular insight in the modulation of COX-2 at post-transcriptional level by miR-101 and strengthen the observation that miRNAs are highly implicated in the control of gene expression; An impairment of miR-101 levels could represent one of the leading causes of COX-2 overexpression in colon cancer cells;Roles of MiR 101 and its target gene Cox 2 in early diagnosis of cervical cancer in Uygur women; Use of down-regulation of miR-101 and up-regulation of Cox-2 as markers may play a role in early diagnosis of cervical cancer in Uygur women;Enforced expression of miR 101 enhances cisplatin sensitivity in human bladder cancer cells by modulating the cyclooxygenase 2 pathway;Downregulation of miR 101 in gastric cancer correlates with cyclooxygenase 2 overexpression and tumor growth; Here we characterize miR-101 expression and its role in the regulation of COX-2 expression which in turn will provide us with additional insights into the potential therapeutic benefits of exogenous miR-101 for treatment of gastric cancer; We also found an inverse correlation between miR-101 and COX-2 expression in both gastric cancer specimens and cell lines; One possible mechanism of interaction is that miR-101 inhibited COX-2 expression by directly binding to the 3'-UTR of COX-2 mRNA; These results collectively indicate that miR-101 may function as a tumor suppressor in gastric cancer with COX-2 as a direct target	;;;;tumorigenesis;progression;tumorigenesis;;;;;;	esophageal cancer;esophageal cancer;prostate cancer;liver cancer;cervical and endocervical cancer;gastric cancer;lung cancer;cervical and endocervical cancer;colon cancer;cervical and endocervical cancer;bladder cancer;gastric cancer
hsa-miR-139-5p	PTK2	-1.83374360776637	1.22019901002824e-09	0.276089305828771	0.103687124058962	miRanda	-0.12481462384513	0.0010434349292379		NA	NA	NA
hsa-miR-140-5p	PTK2	0.208193069681326	0.303002433893804	0.276089305828771	0.103687124058962	miRanda	-0.217261378925225	0.000315148676816685		NA	NA	NA
hsa-miR-199a-5p	PXN	0.371973504507027	0.232661597228763	0.208331781983881	0.34839741772438	MirTarget;PITA;miRNATAP	-0.140557984746987	0.00562717624592664		NA	NA	NA
hsa-miR-199b-5p	PXN	0.124595928096068	0.678156859366405	0.208331781983881	0.34839741772438	MirTarget;PITA;miRNATAP	-0.153146259446499	0.0037129197552008		NA	NA	NA
hsa-miR-30c-5p	RAC1	-0.983130268805942	4.60419218706127e-05	0.63005132289186	0.00013432252267484	miRNAWalker2_validate	-0.215519718166738	7.09586530438521e-06		NA	NA	NA
hsa-miR-375	RAC2	-2.94506033785642	0.00570147601654791	1.62151327855796	1.05038880277147e-05	miRanda	-0.111436700267932	4.91783218198251e-06		NA	NA	NA
hsa-miR-342-3p	RAC3	0.318119432680668	0.269150960124243	0.309748967802459	0.467555115343412	miRanda	-0.296741961155951	0.00517182849282247		NA	NA	NA
hsa-miR-146b-3p	RAF1	1.10138643500522	3.66835580263893e-05	-0.8632101633735	1.53817801108877e-10	MirTarget;PITA;miRNATAP	-0.120516156621644	0.00105150756879764		NA	NA	NA
hsa-miR-484	RAF1	0.71327898984355	0.00233605130771196	-0.8632101633735	1.53817801108877e-10	MirTarget	-0.121560277635947	0.00438132826235516		NA	NA	NA
hsa-miR-497-5p	SH2D2A	-0.801030912431774	0.00360386743876612	2.13297508309025	3.48976296078618e-11	MirTarget	-0.242929996989771	0.00564832358449616		NA	NA	NA
hsa-miR-214-3p	SPHK2	1.01201534142544	0.00625092909225755	-0.0491603714020146	0.805120845741337	mirMAP	-0.144601389464031	0.000113215581829052		NA	NA	NA
hsa-miR-708-5p	SPHK2	1.41830449251856	0.0109647946476309	-0.0491603714020146	0.805120845741337	mirMAP	-0.16530652769245	3.40285176640057e-12		NA	NA	NA
hsa-miR-130a-3p	SRC	0.146223920674657	0.633739795905839	0.250636337543803	0.21661216883498	mirMAP	-0.257164819627156	1.86081643260084e-08		NA	NA	NA
hsa-miR-149-5p	SRC	0.706277554734069	0.296848731347677	0.250636337543803	0.21661216883498	MirTarget	-0.119085772819562	5.6383951142344e-09		NA	NA	NA
hsa-miR-181a-2-3p	SRC	0.901732254836667	0.000830304681396734	0.250636337543803	0.21661216883498	mirMAP	-0.148291924574697	0.00519334410589646		NA	NA	NA
hsa-miR-193b-3p	SRC	0.281752012268679	0.451258902263119	0.250636337543803	0.21661216883498	mirMAP	-0.229548886386808	5.65997510171901e-10		NA	NA	NA
hsa-miR-2355-5p	SRC	0.594869787574182	0.120591076715177	0.250636337543803	0.21661216883498	mirMAP	-0.12476119486514	0.000825374597050988		NA	NA	NA
hsa-miR-23b-3p	SRC	-0.286465516491361	0.18664668472995	0.250636337543803	0.21661216883498	miRNAWalker2_validate;miRTarBase	-0.233629275143521	0.000492285791314835	23074286	miR 23b represses proto oncogene Src kinase and functions as methylation silenced tumor suppressor with diagnostic and prognostic significance in prostate cancer; We showed that proto-oncogene Src kinase and Akt are direct targets of miR-23b; Depletion of Src by RNA interference conferred similar functional effects as that of miR-23b reconstitution; miR-23b expression caused a dramatic decrease in tumor growth in nude mice and attenuated Src expression in excised tumors compared with a control miR		prostate cancer
hsa-miR-34c-5p	SRC	2.20632574870337	0.000379662996168678	0.250636337543803	0.21661216883498	MirTarget;miRanda	-0.111978250831409	5.76861630672127e-07		NA	NA	NA
hsa-miR-654-3p	SRC	-0.180620884059292	0.603937505298333	0.250636337543803	0.21661216883498	mirMAP	-0.11964770959747	0.00384798695416361		NA	NA	NA
hsa-miR-1-3p	VEGFA	-2.66410453456934	1.50620580537836e-05	0.409900110754973	0.180026099055787	MirTarget	-0.176948917904965	1.45151759893735e-07	24966896	The ectopic expression of miR-1 and miR-145 in NOZ cells significantly inhibited cell viability and colony formation P<0.01 and reduced gene expression of VEGF-A and AXL		bladder cancer
hsa-miR-101-3p	VEGFA	-0.451263906815861	0.0283387250173031	0.409900110754973	0.180026099055787	miRNAWalker2_validate	-0.335417986089274	0.00174980396829274		NA	NA	NA
hsa-miR-129-5p	VEGFA	-2.56914016541176	2.36237896095709e-06	0.409900110754973	0.180026099055787	miRanda	-0.105947559794297	0.00736909643879352		NA	NA	NA
hsa-miR-133a-3p	VEGFA	-3.07408796787523	8.17423849601445e-07	0.409900110754973	0.180026099055787	miRNAWalker2_validate	-0.162820736618245	8.37210469369392e-07		NA	NA	NA
hsa-miR-145-5p	VEGFA	-1.75133578902314	1.54965572197748e-05	0.409900110754973	0.180026099055787	miRNAWalker2_validate;miRTarBase	-0.220438811665314	2.09241456816908e-05	24781864;24966896;22472569	Overexpression of miR-145 in thyroid cancer cell lines resulted in: decreased cell proliferation migration invasion VEGF secretion and E-cadherin expression; In vivo miR-145 overexpression decreased tumor growth and metastasis in a xenograft mouse model and VEGF secretion;The ectopic expression of miR-1 and miR-145 in NOZ cells significantly inhibited cell viability and colony formation P<0.01 and reduced gene expression of VEGF-A and AXL;Furthermore the results showed that vascular endothelial growth factor VEGF expression was down-regulated in osteosarcoma cells after miR-145 transfection; On the basis of these results we performed the luciferase assay and verified that miR-145 could down-regulate VEGF at the translational level by partially binding to VEGF 3' untranslated region 3'UTR; One of the mechanisms is the down-regulation of VEGF expression by miR-145 by binding to the 3'UTR of VEGF mRNA specifically	metastasis;;	thyroid cancer;bladder cancer;sarcoma
hsa-miR-199a-5p	VEGFA	0.371973504507027	0.232661597228763	0.409900110754973	0.180026099055787	miRanda;miRNATAP	-0.211547585175076	0.00251514147236996	25444917	In addition co-transfection with miR-199a mimic reversed the CCL5-mediated VEGF expression and angiogenesis in vitro and in vivo		sarcoma