miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-101-3p AKT3 0.522819989585461 0.00375627731618038 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.334857831597034 0.000597756240419548 NA NA NA hsa-miR-106a-5p AKT3 2.48882002962836 1.99757727374521e-12 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.236478824223264 6.56988295029948e-07 NA NA NA hsa-miR-106b-5p AKT3 2.46782146831112 1.36171495805632e-23 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.521755012930227 1.0756262414999e-15 NA NA NA hsa-miR-107 AKT3 1.30977326593435 1.30372468603965e-11 -1.94162990884529 4.54380296394505e-08 PITA;miRanda -0.438321009170574 6.41595199298462e-07 NA NA NA hsa-miR-15a-5p AKT3 2.34669284378787 1.69544424500258e-23 -1.94162990884529 4.54380296394505e-08 miRNAWalker2_validate;miRTarBase;miRNATAP -0.653282073492048 2.38693369892811e-22 NA NA NA hsa-miR-15b-5p AKT3 1.57112623124278 9.14247846750597e-13 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.4862313443712 1.80429141906685e-10 NA NA NA hsa-miR-16-5p AKT3 1.75824877145857 1.68592440033108e-16 -1.94162990884529 4.54380296394505e-08 miRNAWalker2_validate;miRTarBase;miRNATAP -0.527819854451446 1.06852141480407e-11 NA NA NA hsa-miR-17-3p AKT3 2.2704817679209 1.1667437320211e-22 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.393678889428456 2.72155279297878e-08 NA NA NA hsa-miR-17-5p AKT3 3.2710598467455 9.93128340539455e-27 -1.94162990884529 4.54380296394505e-08 TargetScan;miRNATAP -0.385876321416217 1.42856705542315e-13 NA NA NA hsa-miR-181a-5p AKT3 2.29556023480783 1.8138457900616e-21 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.283343247743329 3.77571043690309e-05 NA NA NA hsa-miR-181b-5p AKT3 2.49307679431293 3.92829250217627e-20 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.273550202394616 7.65012329836386e-06 NA NA NA hsa-miR-181c-5p AKT3 1.58587920618301 1.57506918816933e-10 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.234902996176996 0.000670085449584041 NA NA NA hsa-miR-20a-5p AKT3 3.15577933619191 4.19753346442454e-25 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.397380097014522 3.56434655429537e-14 NA NA NA hsa-miR-20b-5p AKT3 2.07706563022469 1.10107236083433e-05 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.159136097484426 1.15057100055016e-05 NA NA NA hsa-miR-22-3p AKT3 1.21545661147757 1.61670170137775e-13 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.356198759053997 0.000637369773108939 NA NA NA hsa-miR-29b-2-5p AKT3 0.910668640983475 0.00666655585493488 -1.94162990884529 4.54380296394505e-08 mirMAP -0.413342005890553 1.74596670459023e-16 NA NA NA hsa-miR-29b-3p AKT3 1.65828197923813 1.02676780888141e-09 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.328715384299769 1.41956551647306e-07 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-29c-3p AKT3 -0.00968972577705429 0.97099586346872 -1.94162990884529 4.54380296394505e-08 miRNAWalker2_validate;miRNATAP -0.256484648428124 9.16722320814547e-05 NA NA NA hsa-miR-3065-5p AKT3 2.74629919868982 1.86846589298284e-08 -1.94162990884529 4.54380296394505e-08 mirMAP -0.196776388311872 4.09483787014971e-06 NA NA NA hsa-miR-32-3p AKT3 2.02436999565685 5.94091197945307e-09 -1.94162990884529 4.54380296394505e-08 mirMAP -0.274043726011417 8.75730973684685e-07 NA NA NA hsa-miR-320a AKT3 0.438165828017084 0.0390159073347133 -1.94162990884529 4.54380296394505e-08 PITA;miRanda;miRNATAP -0.539139659729602 3.01448987258332e-11 NA NA NA hsa-miR-320b AKT3 1.55692969039548 1.41071034251915e-08 -1.94162990884529 4.54380296394505e-08 PITA;miRanda;miRNATAP -0.376164976249955 1.04134326075959e-09 NA NA NA hsa-miR-335-3p AKT3 3.08791651139852 5.31309869723517e-12 -1.94162990884529 4.54380296394505e-08 mirMAP -0.222130607012057 2.63416728864213e-09 NA NA NA hsa-miR-33a-3p AKT3 1.72765312072219 1.51784443453521e-07 -1.94162990884529 4.54380296394505e-08 mirMAP -0.325733544419159 9.28241682908522e-09 NA NA NA hsa-miR-362-3p AKT3 2.0756816987665 3.89026064579331e-12 -1.94162990884529 4.54380296394505e-08 miRanda -0.16536843343699 0.0049777492806053 NA NA NA hsa-miR-362-5p AKT3 1.59303749908759 9.582675908797e-08 -1.94162990884529 4.54380296394505e-08 PITA;TargetScan;miRNATAP -0.201169258976553 0.000472996311050305 NA NA NA hsa-miR-374a-5p AKT3 0.484615721953736 0.0042981729815149 -1.94162990884529 4.54380296394505e-08 mirMAP -0.289501808595266 0.00547104114009117 NA NA NA hsa-miR-421 AKT3 1.17791565395543 6.78526676976629e-06 -1.94162990884529 4.54380296394505e-08 miRanda;mirMAP -0.270003673244585 4.40560995362011e-05 NA NA NA hsa-miR-501-3p AKT3 1.83132758513743 1.10971547702065e-10 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.357094776714992 1.69773165528929e-09 NA NA NA hsa-miR-502-3p AKT3 1.50560877085049 1.2647489756373e-11 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.326505295822604 2.04961437337709e-05 NA NA NA hsa-miR-505-3p AKT3 1.45322244209148 8.86597629645867e-10 -1.94162990884529 4.54380296394505e-08 mirMAP -0.409352554521824 1.03207996907079e-08 22051041 We also find that Akt3 correlate inversely with miR-505 modulates drug sensitivity in MCF7-ADR breast cancer hsa-miR-769-5p AKT3 1.82023760596845 9.6815886564134e-14 -1.94162990884529 4.54380296394505e-08 PITA;miRNATAP -0.445071301297515 6.71512496875401e-11 NA NA NA hsa-miR-93-5p AKT3 3.03961860136032 1.11672209617395e-24 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.494281511913237 1.38435165024812e-20 NA NA NA hsa-miR-219a-1-3p ARRB1 1.14752647140971 0.00048791524196346 -1.05321698066149 0.000430207591399783 MirTarget -0.221314596757233 7.37444547494468e-06 NA NA NA hsa-miR-331-3p ARRB1 2.28379581858927 1.99663919173155e-18 -1.05321698066149 0.000430207591399783 MirTarget;miRNATAP -0.203161323446285 0.000144488820805228 NA NA NA hsa-miR-455-3p ARRB1 3.06093594997644 3.54590649799868e-16 -1.05321698066149 0.000430207591399783 MirTarget -0.208088516167609 1.58266377779499e-08 NA NA NA hsa-miR-550a-5p ARRB1 2.11025227932763 6.94489556637146e-12 -1.05321698066149 0.000430207591399783 MirTarget -0.209933123266983 4.96757434920662e-06 NA NA NA hsa-miR-671-5p ARRB1 2.97733652243246 1.21148452344738e-23 -1.05321698066149 0.000430207591399783 MirTarget -0.176429044128967 0.00031015524168394 NA NA NA hsa-miR-92a-3p ARRB1 2.06460102658973 1.44784291084757e-19 -1.05321698066149 0.000430207591399783 miRNAWalker2_validate -0.329935624320977 4.9976361283895e-08 NA NA NA hsa-miR-205-5p ARRB2 4.1389800495524 2.05488295686453e-12 0.184469680691642 0.361260278780853 miRNATAP -0.122571268152989 3.54527273138056e-15 NA NA NA hsa-miR-10b-5p ATF2 -0.155951595811628 0.555006386998027 -0.360334142061557 0.0913687862766104 MirTarget;miRNATAP -0.112522576994954 0.00414026865369324 NA NA NA hsa-miR-126-5p ATF2 0.895338176458417 2.33372756450713e-05 -0.360334142061557 0.0913687862766104 mirMAP -0.14881216970424 0.00223637271112211 NA NA NA hsa-miR-140-3p ATF2 0.0608890720479334 0.727716871248724 -0.360334142061557 0.0913687862766104 MirTarget;PITA;miRNATAP -0.204011014456392 0.000651503450345203 NA NA NA hsa-miR-15a-5p ATF2 2.34669284378787 1.69544424500258e-23 -0.360334142061557 0.0913687862766104 miRNAWalker2_validate -0.170687494407351 3.95479356045233e-05 NA NA NA hsa-miR-181a-5p ATF2 2.29556023480783 1.8138457900616e-21 -0.360334142061557 0.0913687862766104 mirMAP;miRNATAP -0.176303985611759 1.39870223725171e-05 NA NA NA hsa-miR-181b-5p ATF2 2.49307679431293 3.92829250217627e-20 -0.360334142061557 0.0913687862766104 mirMAP;miRNATAP -0.103909488174035 0.00428377219177581 NA NA NA hsa-miR-181c-5p ATF2 1.58587920618301 1.57506918816933e-10 -0.360334142061557 0.0913687862766104 mirMAP;miRNATAP -0.185195599739143 5.03828082080802e-06 NA NA NA hsa-miR-194-5p ATF2 1.8992998339217 3.76507853301977e-10 -0.360334142061557 0.0913687862766104 miRNATAP -0.107350599250521 0.00126943098471402 NA NA NA hsa-miR-19a-3p ATF2 3.42309334186656 3.02671914353412e-28 -0.360334142061557 0.0913687862766104 MirTarget;miRNATAP -0.127513126044015 3.6737554818488e-05 NA NA NA hsa-miR-19b-3p ATF2 2.49529833021187 1.57028265846699e-23 -0.360334142061557 0.0913687862766104 miRNAWalker2_validate;MirTarget;miRNATAP -0.159184178998869 4.56232246190828e-05 NA NA NA hsa-miR-26b-5p ATF2 0.885393662798425 3.2116297961629e-06 -0.360334142061557 0.0913687862766104 MirTarget;miRNATAP -0.190104058076874 0.000446414188712241 21901137 Coordinated regulation of ATF2 by miR 26b in γ irradiated lung cancer cells; Concurrent analysis of time-series mRNA and microRNA profiles uncovered that expression of miR-26b was down regulated and its target activating transcription factor 2 ATF2 mRNA was up regulated in γ-irradiated H1299 cells; IR in miR-26b overexpressed H1299 cells could not induce expression of ATF2; From these results we concluded that IR-induced up-regulation of ATF2 was coordinately enhanced by suppression of miR-26b in lung cancer cells which may enhance the effect of IR in the MAPK signaling pathway lung cancer hsa-miR-29a-5p ATF2 1.46749674755271 3.34605004270294e-07 -0.360334142061557 0.0913687862766104 MirTarget;miRNATAP -0.107282429424317 0.00424592492232286 NA NA NA hsa-miR-30a-5p ATF2 -0.878357906436456 0.000509952992366057 -0.360334142061557 0.0913687862766104 mirMAP -0.143058316365483 0.000436069853407003 NA NA NA hsa-miR-30b-5p ATF2 0.800822374912712 0.000133601914525413 -0.360334142061557 0.0913687862766104 mirMAP -0.208599821399784 2.06942579229443e-05 NA NA NA hsa-miR-30c-5p ATF2 0.778774633108 0.000285599212429136 -0.360334142061557 0.0913687862766104 mirMAP -0.302052934745697 1.60579370141006e-10 NA NA NA hsa-miR-30d-5p ATF2 0.675423997639582 0.00270618816039773 -0.360334142061557 0.0913687862766104 mirMAP -0.12763525078152 0.0054928443467875 NA NA NA hsa-miR-30e-5p ATF2 1.23904909539663 1.35561917122157e-09 -0.360334142061557 0.0913687862766104 mirMAP -0.250004980337073 4.19406363604627e-07 NA NA NA hsa-miR-320a ATF2 0.438165828017084 0.0390159073347133 -0.360334142061557 0.0913687862766104 miRanda -0.161156676452192 0.000977853785293753 NA NA NA hsa-miR-582-5p ATF2 0.609226359812689 0.032988717891497 -0.360334142061557 0.0913687862766104 MirTarget;miRNATAP -0.111875088913283 0.00195464990636449 NA NA NA hsa-miR-590-3p ATF2 2.59289455139753 1.03200520972022e-21 -0.360334142061557 0.0913687862766104 MirTarget;miRanda;mirMAP;miRNATAP -0.115458834968422 0.00194384711428695 NA NA NA hsa-let-7b-3p BDNF 0.868207752019623 1.30460056774366e-05 -2.90846311399482 3.32327619207597e-11 MirTarget;miRNATAP -0.285067683917082 0.00912745906089909 NA NA NA hsa-miR-103a-3p BDNF 1.44083190496858 1.53799939616416e-13 -2.90846311399482 3.32327619207597e-11 MirTarget;miRNATAP -0.513010583082046 2.18583657796716e-06 NA NA NA hsa-miR-107 BDNF 1.30977326593435 1.30372468603965e-11 -2.90846311399482 3.32327619207597e-11 MirTarget;PITA;miRanda;miRNATAP -0.301411719956826 0.00652496504590489 27498977 MicroRNA 107 inhibits tumor growth and metastasis by targeting the BDNF mediated PI3K/AKT pathway in human non small lung cancer; In addition BDNF expression was upregulated and inversely correlated with miR-107 in NSCLC tissues; Enforced overexpression of BDNF effectively reversed the tumor suppressive functions of miR-107 on NSCLC proliferation migration and invasion; miR-107 overexpression or downregulation of BDNF was able to inhibit activation of PI3K/AKT signaling pathway; Taken together our findings present the first evidence that miR-107 could suppress NSCLC metastasis by targeting BDNF and indirectly regulating PI3K/AKT signaling pathway which might lead to a potential therapeutic strategy focusing on miR-107 and BDNF for human NSCLC metastasis lung cancer hsa-miR-10a-5p BDNF 1.15016989191194 0.00372037233992369 -2.90846311399482 3.32327619207597e-11 MirTarget;miRNATAP -0.239868149823933 9.76923403527126e-06 NA NA NA hsa-miR-15a-5p BDNF 2.34669284378787 1.69544424500258e-23 -2.90846311399482 3.32327619207597e-11 MirTarget;miRNATAP -0.538797123359211 4.53591149420254e-10 26581909 MicroRNA 15a 5p suppresses cancer proliferation and division in human hepatocellular carcinoma by targeting BDNF; BDNF was then overexpressed in HepG2 and SNU-182 cells to evaluate its selective effect on miR-15a-5p in HCC modulation; MiR-15a-5p selectively and negatively regulated BDNF at both gene and protein levels in HCC cells; Forced overexpression of BDNF effectively reversed the tumor suppressive functions of miR-15a-5p on HCC proliferation and cell division in vitro; Our study demonstrated that miR-15a-5p is a tumor suppressor in HCC and its regulation is through BDNF in HCC liver cancer hsa-miR-15b-5p BDNF 1.57112623124278 9.14247846750597e-13 -2.90846311399482 3.32327619207597e-11 MirTarget;miRNATAP -0.337417459977062 0.000476250471995874 NA NA NA hsa-miR-16-5p BDNF 1.75824877145857 1.68592440033108e-16 -2.90846311399482 3.32327619207597e-11 MirTarget;miRNATAP -0.404475155904508 3.95284638464173e-05 NA NA NA hsa-miR-182-5p BDNF 3.53923166221814 5.07781258121574e-21 -2.90846311399482 3.32327619207597e-11 MirTarget;miRNATAP -0.304142174368882 2.036484274037e-08 NA NA NA hsa-miR-191-5p BDNF 2.30038190670664 9.93191704545938e-17 -2.90846311399482 3.32327619207597e-11 miRNATAP -0.485298765179322 6.26143603678241e-11 NA NA NA hsa-miR-210-3p BDNF 6.07079758655679 2.22120227133377e-28 -2.90846311399482 3.32327619207597e-11 miRNAWalker2_validate;miRTarBase -0.237223359082858 5.07246234320821e-11 NA NA NA hsa-miR-22-3p BDNF 1.21545661147757 1.61670170137775e-13 -2.90846311399482 3.32327619207597e-11 miRNAWalker2_validate;miRTarBase -0.538030930409075 3.25374878143957e-05 NA NA NA hsa-miR-26b-3p BDNF 2.18464160365372 2.11543189388328e-18 -2.90846311399482 3.32327619207597e-11 MirTarget -0.444310109951697 8.07362790493106e-08 NA NA NA hsa-miR-29b-2-5p BDNF 0.910668640983475 0.00666655585493488 -2.90846311399482 3.32327619207597e-11 mirMAP -0.385323162445974 1.40825527826931e-09 NA NA NA hsa-miR-3065-3p BDNF 2.16221780121195 9.65525739884541e-09 -2.90846311399482 3.32327619207597e-11 MirTarget;miRNATAP -0.207023369564498 0.000246555472230515 NA NA NA hsa-miR-3065-5p BDNF 2.74629919868982 1.86846589298284e-08 -2.90846311399482 3.32327619207597e-11 mirMAP;miRNATAP -0.168376118012365 0.00167095455996276 NA NA NA hsa-miR-30c-5p BDNF 0.778774633108 0.000285599212429136 -2.90846311399482 3.32327619207597e-11 miRNATAP -0.452622492319709 7.0923627825397e-06 NA NA NA hsa-miR-30d-5p BDNF 0.675423997639582 0.00270618816039773 -2.90846311399482 3.32327619207597e-11 miRNATAP -0.31555337460895 0.00110619099852774 NA NA NA hsa-miR-30e-5p BDNF 1.23904909539663 1.35561917122157e-09 -2.90846311399482 3.32327619207597e-11 miRNATAP -0.710933428108993 4.68409714514429e-12 NA NA NA hsa-miR-330-3p BDNF 0.876747334239085 0.00073709016089703 -2.90846311399482 3.32327619207597e-11 MirTarget -0.350307363358734 2.52309207840318e-05 NA NA NA hsa-miR-339-5p BDNF 2.68710938429893 3.03134080808154e-16 -2.90846311399482 3.32327619207597e-11 miRanda -0.208909558420091 0.0010320906387239 NA NA NA hsa-miR-33a-3p BDNF 1.72765312072219 1.51784443453521e-07 -2.90846311399482 3.32327619207597e-11 mirMAP -0.189569900102124 0.00822808887496796 NA NA NA hsa-miR-361-5p BDNF 0.971859117235239 5.30236555707088e-09 -2.90846311399482 3.32327619207597e-11 PITA;miRanda;miRNATAP -0.549614574828476 2.2273701996563e-05 NA NA NA hsa-miR-3913-5p BDNF 2.44353493655328 8.95279496632448e-15 -2.90846311399482 3.32327619207597e-11 mirMAP -0.401161818585588 3.16401389217705e-09 NA NA NA hsa-miR-452-3p BDNF 2.42521958420768 4.08754552781156e-07 -2.90846311399482 3.32327619207597e-11 MirTarget -0.15349375691044 0.000617556235812272 NA NA NA hsa-miR-452-5p BDNF 1.37180058737183 0.00171494843537772 -2.90846311399482 3.32327619207597e-11 miRNATAP -0.159672549433471 0.00121343995890147 NA NA NA hsa-miR-589-3p BDNF 2.51971841868825 2.39125940264107e-11 -2.90846311399482 3.32327619207597e-11 MirTarget -0.19485326256731 0.00234458194019574 NA NA NA hsa-miR-590-3p BDNF 2.59289455139753 1.03200520972022e-21 -2.90846311399482 3.32327619207597e-11 miRanda;mirMAP;miRNATAP -0.215106825481362 0.00623574226190281 NA NA NA hsa-miR-944 BDNF 2.91186649218281 1.31574753528144e-06 -2.90846311399482 3.32327619207597e-11 PITA;mirMAP;miRNATAP -0.210249837446185 6.49747993753151e-09 NA NA NA hsa-miR-146b-5p BRAF 1.75587235896724 1.15724631266659e-07 -0.0380624164019494 0.839544086141468 miRanda -0.146633871679738 3.64395605099119e-08 21874046;26883911;20406109;21537871 Additionally the activation of thyroid most common oncogenes RET/PTC3 and BRAF in PCCL3 cells upregulated miR-146b-5p expression;miR-146b-5p positively regulates migration and invasion of thyroid normal and tumor follicular cells independently from their original mutation either BRAF or RET/PTC through a mechanism that involves the actin cytoskeleton but not an increased capacity of matrix degradation;The miR-146b expression levels in PTCs with BRAF mutation were significantly higher than those without this mutation p < 0.0001;Among BRAF-positive tumors overexpression of miR-146b was associated with aggressive behavior suggesting that it may further refine the prognostic importance of BRAF ;;; thyroid cancer;thyroid cancer;thyroid cancer;thyroid cancer hsa-miR-199a-5p BRAF 0.592984035153911 0.0674836634175293 -0.0380624164019494 0.839544086141468 miRanda -0.100551330747605 0.000311009640639109 NA NA NA hsa-miR-3614-5p CACNA1B 2.17736331059655 2.19144831318484e-08 0.253556623703701 0.683032730923114 mirMAP;miRNATAP -0.234400994963555 0.00283006464200813 NA NA NA hsa-let-7a-3p CACNA1C 1.42015538786275 7.03375209382654e-13 -2.53203105122136 8.2041496030931e-11 MirTarget -0.851416371027471 1.34543112777104e-20 NA NA NA hsa-let-7b-3p CACNA1C 0.868207752019623 1.30460056774366e-05 -2.53203105122136 8.2041496030931e-11 MirTarget -0.682461369871617 5.13265891046908e-13 NA NA NA hsa-let-7f-1-3p CACNA1C 1.55054488387679 7.31326775537952e-11 -2.53203105122136 8.2041496030931e-11 MirTarget -0.528073482951376 4.86557059568698e-11 NA NA NA hsa-miR-107 CACNA1C 1.30977326593435 1.30372468603965e-11 -2.53203105122136 8.2041496030931e-11 miRNATAP -0.81623188699233 6.11116743131426e-18 NA NA NA hsa-miR-1271-5p CACNA1C 0.970418832993172 0.000609742584380688 -2.53203105122136 8.2041496030931e-11 MirTarget -0.345270208150912 3.04703010706311e-07 NA NA NA hsa-miR-129-5p CACNA1C -0.524170159980738 0.222582956006346 -2.53203105122136 8.2041496030931e-11 PITA;miRanda -0.131390538818425 0.00410395089279093 NA NA NA hsa-miR-140-5p CACNA1C 0.844753502512594 3.73722278438606e-05 -2.53203105122136 8.2041496030931e-11 PITA;miRNATAP -0.342509206669341 0.00026923633766492 NA NA NA hsa-miR-148b-5p CACNA1C 2.18024067300781 2.84770452413262e-14 -2.53203105122136 8.2041496030931e-11 mirMAP -0.697088250744961 7.58937688183364e-27 NA NA NA hsa-miR-149-5p CACNA1C 2.94200492826326 4.93436498919036e-14 -2.53203105122136 8.2041496030931e-11 MirTarget -0.300731938861626 1.48507203319834e-10 NA NA NA hsa-miR-186-5p CACNA1C 1.47445398888668 3.0781726595413e-15 -2.53203105122136 8.2041496030931e-11 mirMAP -1.00918384444682 2.23258138184231e-26 NA NA NA hsa-miR-192-5p CACNA1C 2.69002528723195 1.22990188194432e-16 -2.53203105122136 8.2041496030931e-11 mirMAP -0.451274094209666 3.36404707261037e-16 NA NA NA hsa-miR-1976 CACNA1C 2.06550563678192 7.81396978619772e-18 -2.53203105122136 8.2041496030931e-11 MirTarget -0.887478312520501 1.3061933802299e-35 NA NA NA hsa-miR-19a-3p CACNA1C 3.42309334186656 3.02671914353412e-28 -2.53203105122136 8.2041496030931e-11 MirTarget -0.619614485684016 2.49661068141548e-30 NA NA NA hsa-miR-19b-1-5p CACNA1C 2.57951428759379 4.31576118703427e-20 -2.53203105122136 8.2041496030931e-11 MirTarget -0.781347683163025 1.5653325720176e-36 NA NA NA hsa-miR-19b-3p CACNA1C 2.49529833021187 1.57028265846699e-23 -2.53203105122136 8.2041496030931e-11 MirTarget -0.806227418765485 2.16644482796282e-32 NA NA NA hsa-miR-200b-3p CACNA1C 3.78235093249346 3.18343003239465e-14 -2.53203105122136 8.2041496030931e-11 MirTarget;TargetScan -0.302469221684908 5.35891643019559e-17 NA NA NA hsa-miR-200c-3p CACNA1C 3.50132673580082 2.42716349086937e-15 -2.53203105122136 8.2041496030931e-11 MirTarget -0.436093474539072 1.71924843611962e-28 NA NA NA hsa-miR-26b-5p CACNA1C 0.885393662798425 3.2116297961629e-06 -2.53203105122136 8.2041496030931e-11 MirTarget;miRNATAP -0.905755674895682 9.80433409498862e-21 NA NA NA hsa-miR-29b-3p CACNA1C 1.65828197923813 1.02676780888141e-09 -2.53203105122136 8.2041496030931e-11 MirTarget -0.558351504983861 1.23727367293804e-16 NA NA NA hsa-miR-30b-5p CACNA1C 0.800822374912712 0.000133601914525413 -2.53203105122136 8.2041496030931e-11 mirMAP -0.458786629024958 5.03114650687994e-07 NA NA NA hsa-miR-30c-5p CACNA1C 0.778774633108 0.000285599212429136 -2.53203105122136 8.2041496030931e-11 mirMAP -0.503520915942482 1.44304709019317e-08 NA NA NA hsa-miR-30d-5p CACNA1C 0.675423997639582 0.00270618816039773 -2.53203105122136 8.2041496030931e-11 mirMAP -0.454577277369657 8.76671070869687e-08 NA NA NA hsa-miR-30e-5p CACNA1C 1.23904909539663 1.35561917122157e-09 -2.53203105122136 8.2041496030931e-11 mirMAP -0.837285672353271 5.91841143085479e-21 NA NA NA hsa-miR-320a CACNA1C 0.438165828017084 0.0390159073347133 -2.53203105122136 8.2041496030931e-11 miRNATAP -0.575307540613803 1.53204814048867e-10 NA NA NA hsa-miR-320b CACNA1C 1.55692969039548 1.41071034251915e-08 -2.53203105122136 8.2041496030931e-11 miRNATAP -0.610393782137628 3.36671266062009e-20 NA NA NA hsa-miR-330-5p CACNA1C 1.15100069700871 4.85551805046014e-07 -2.53203105122136 8.2041496030931e-11 miRanda -0.638517081333152 3.7980709378733e-15 NA NA NA hsa-miR-33a-5p CACNA1C 3.79671563098419 1.15966309820345e-18 -2.53203105122136 8.2041496030931e-11 MirTarget -0.457154122461845 3.5482061694801e-25 NA NA NA hsa-miR-342-3p CACNA1C 1.49115144672245 1.43879249744621e-07 -2.53203105122136 8.2041496030931e-11 MirTarget;PITA;miRanda;miRNATAP -0.371121100845429 2.23992393068203e-08 NA NA NA hsa-miR-34a-5p CACNA1C 1.9016323452565 1.43092834643601e-14 -2.53203105122136 8.2041496030931e-11 MirTarget -0.482930202130142 8.6203015431497e-11 NA NA NA hsa-miR-34c-5p CACNA1C 2.07190852984647 7.35776320806257e-08 -2.53203105122136 8.2041496030931e-11 MirTarget;miRanda -0.19402578777384 0.000219949911183245 NA NA NA hsa-miR-361-3p CACNA1C 1.07367425434318 1.73142774168958e-09 -2.53203105122136 8.2041496030931e-11 MirTarget -0.913268181434953 9.41575789452395e-19 NA NA NA hsa-miR-378a-5p CACNA1C 0.223456081148306 0.386368843153575 -2.53203105122136 8.2041496030931e-11 MirTarget -0.437568519803884 3.43400908177221e-09 NA NA NA hsa-miR-421 CACNA1C 1.17791565395543 6.78526676976629e-06 -2.53203105122136 8.2041496030931e-11 MirTarget;PITA;miRanda;miRNATAP -0.435765298925044 1.61537307711297e-09 NA NA NA hsa-miR-429 CACNA1C 4.48815175680773 2.44117492218206e-17 -2.53203105122136 8.2041496030931e-11 MirTarget;PITA;miRanda;miRNATAP -0.292929235517198 2.53384103198919e-18 NA NA NA hsa-miR-484 CACNA1C 1.81844463411787 1.82951571230938e-15 -2.53203105122136 8.2041496030931e-11 PITA;miRNATAP -0.74555045640928 1.40700127880282e-21 NA NA NA hsa-miR-491-5p CACNA1C 0.615770352820862 0.0418295628761654 -2.53203105122136 8.2041496030931e-11 MirTarget -0.352420094312488 1.95488972759976e-07 NA NA NA hsa-miR-532-5p CACNA1C 1.55697650978597 1.57884735535196e-11 -2.53203105122136 8.2041496030931e-11 PITA -0.51717444962508 1.26650423602727e-10 NA NA NA hsa-miR-582-5p CACNA1C 0.609226359812689 0.032988717891497 -2.53203105122136 8.2041496030931e-11 PITA -0.341423117039247 3.38904661397262e-07 NA NA NA hsa-miR-589-3p CACNA1C 2.51971841868825 2.39125940264107e-11 -2.53203105122136 8.2041496030931e-11 MirTarget;mirMAP -0.510899518749256 4.83453190957154e-21 NA NA NA hsa-miR-660-5p CACNA1C 1.82692095272076 1.92040083607196e-13 -2.53203105122136 8.2041496030931e-11 MirTarget -0.434009353073276 6.01470537781287e-09 NA NA NA hsa-miR-671-3p CACNA1C 2.20199226665068 7.0886613366934e-16 -2.53203105122136 8.2041496030931e-11 miRNATAP -0.48998102300365 2.00355886799484e-13 NA NA NA hsa-miR-7-1-3p CACNA1C 1.84950311431067 1.25300363397654e-13 -2.53203105122136 8.2041496030931e-11 MirTarget -0.686086865223456 1.24176533528174e-21 NA NA NA hsa-miR-877-5p CACNA1C 2.94916202082736 1.8151927276044e-13 -2.53203105122136 8.2041496030931e-11 MirTarget -0.484149022455047 5.02898842269764e-22 NA NA NA hsa-miR-93-3p CACNA1C 2.85383869771942 5.64481766902125e-23 -2.53203105122136 8.2041496030931e-11 mirMAP -0.669370051234053 9.48295336360919e-30 NA NA NA hsa-miR-944 CACNA1C 2.91186649218281 1.31574753528144e-06 -2.53203105122136 8.2041496030931e-11 mirMAP -0.33290650665113 1.63607521432324e-27 NA NA NA hsa-miR-96-5p CACNA1C 4.89433085814374 1.92000659886961e-31 -2.53203105122136 8.2041496030931e-11 MirTarget;TargetScan -0.450961713358871 3.50832794662548e-28 NA NA NA hsa-let-7a-2-3p CACNA1D 0.0400317820791161 0.91528727576685 -0.488450332427106 0.500571860050304 MirTarget -0.493607077074802 1.32560480959003e-07 NA NA NA hsa-let-7i-5p CACNA1D 0.412877696970403 0.00622731051981756 -0.488450332427106 0.500571860050304 miRNATAP -0.812943501052944 0.000578146303312492 NA NA NA hsa-miR-134-5p CACNA1D 0.141163006984518 0.655334296084178 -0.488450332427106 0.500571860050304 MirTarget -0.47074142111292 2.04234794934576e-05 NA NA NA hsa-miR-135b-5p CACNA1D 3.62510365056501 1.09148980810091e-10 -0.488450332427106 0.500571860050304 MirTarget -0.200917550517875 0.00183783855681936 NA NA NA hsa-miR-142-3p CACNA1D 2.75247908790621 1.45636065474764e-12 -0.488450332427106 0.500571860050304 miRanda -0.632512109168818 1.18312246571606e-13 NA NA NA hsa-miR-342-3p CACNA1D 1.49115144672245 1.43879249744621e-07 -0.488450332427106 0.500571860050304 miRanda -0.426786359327138 0.000463089053455488 NA NA NA hsa-miR-629-5p CACNA1D 2.10182419359635 1.51788571125757e-15 -0.488450332427106 0.500571860050304 MirTarget -0.359374282551407 0.00529995537970961 NA NA NA hsa-miR-590-3p CACNA1G 2.59289455139753 1.03200520972022e-21 -1.07458583690601 0.0109617521589857 miRanda -0.229846825592963 0.00189759101705817 NA NA NA hsa-miR-590-5p CACNA1G 3.18300989862077 2.06813568597893e-26 -1.07458583690601 0.0109617521589857 miRanda -0.229872335668943 0.00049222244660495 NA NA NA hsa-miR-629-3p CACNA1G 2.36570947321815 1.33458201201618e-11 -1.07458583690601 0.0109617521589857 MirTarget -0.169257720198302 0.00891892393401303 NA NA NA hsa-miR-96-5p CACNA1G 4.89433085814374 1.92000659886961e-31 -1.07458583690601 0.0109617521589857 TargetScan -0.123356635029188 0.00791990195617228 NA NA NA hsa-miR-32-5p CACNA1H 2.34056473219422 6.24134585974322e-20 -3.60445826055485 4.84593937053517e-17 miRNATAP -0.829553552374598 7.83615940583391e-28 NA NA NA hsa-miR-361-3p CACNA1H 1.07367425434318 1.73142774168958e-09 -3.60445826055485 4.84593937053517e-17 MirTarget;mirMAP -0.96900981635446 8.05135633688017e-17 NA NA NA hsa-miR-92a-3p CACNA1H 2.06460102658973 1.44784291084757e-19 -3.60445826055485 4.84593937053517e-17 miRNATAP -1.09583781637561 5.48183328640207e-40 NA NA NA hsa-miR-92b-3p CACNA1H 1.20409245530001 3.41055816361655e-06 -3.60445826055485 4.84593937053517e-17 miRNATAP -0.652337562706513 3.69574957748792e-16 NA NA NA hsa-miR-214-3p CACNA1I -0.176344800034733 0.642485503428886 0.568236191196781 0.412494957989746 mirMAP;miRNATAP -0.268974593951976 0.00239947486173748 NA NA NA hsa-miR-222-5p CACNA1I 1.25632771414778 0.000138653440511922 0.568236191196781 0.412494957989746 mirMAP -0.530955145349795 1.05690400162706e-07 NA NA NA hsa-miR-2355-5p CACNA1I 1.32510310704724 8.25139516692683e-07 0.568236191196781 0.412494957989746 MirTarget -0.401460404628556 0.00113965253452992 NA NA NA hsa-miR-766-3p CACNA1I 1.2456012547833 6.44584025471128e-06 0.568236191196781 0.412494957989746 mirMAP -0.345290255708451 0.00417298210579979 NA NA NA hsa-miR-92b-3p CACNA1I 1.20409245530001 3.41055816361655e-06 0.568236191196781 0.412494957989746 MirTarget;miRNATAP -0.393008148296784 0.00219292326076598 NA NA NA hsa-let-7a-3p CACNA2D1 1.42015538786275 7.03375209382654e-13 -3.31556565717047 8.68804644381516e-07 mirMAP -0.501565939634551 0.00220543133729437 NA NA NA hsa-miR-103a-3p CACNA2D1 1.44083190496858 1.53799939616416e-13 -3.31556565717047 8.68804644381516e-07 miRNATAP -1.48785077349547 6.0237211069224e-21 NA NA NA hsa-miR-107 CACNA2D1 1.30977326593435 1.30372468603965e-11 -3.31556565717047 8.68804644381516e-07 PITA;miRanda;miRNATAP -0.850009099829736 3.32378967489299e-07 NA NA NA hsa-miR-126-5p CACNA2D1 0.895338176458417 2.33372756450713e-05 -3.31556565717047 8.68804644381516e-07 mirMAP -0.600254700228478 0.000112468607518709 NA NA NA hsa-miR-141-3p CACNA2D1 5.02396127982626 2.19224509139725e-24 -3.31556565717047 8.68804644381516e-07 TargetScan -0.712756989651708 1.52663401986901e-34 NA NA NA hsa-miR-16-2-3p CACNA2D1 2.31623086727196 4.29838149388188e-20 -3.31556565717047 8.68804644381516e-07 mirMAP -0.782545784623107 2.05271692877172e-10 NA NA NA hsa-miR-16-5p CACNA2D1 1.75824877145857 1.68592440033108e-16 -3.31556565717047 8.68804644381516e-07 miRNAWalker2_validate -1.08911793067024 9.35619842739922e-14 NA NA NA hsa-miR-181a-5p CACNA2D1 2.29556023480783 1.8138457900616e-21 -3.31556565717047 8.68804644381516e-07 mirMAP -0.884406338388322 4.53767756129163e-12 NA NA NA hsa-miR-181b-5p CACNA2D1 2.49307679431293 3.92829250217627e-20 -3.31556565717047 8.68804644381516e-07 mirMAP -0.736518754418169 1.14952057177369e-10 NA NA NA hsa-miR-181c-5p CACNA2D1 1.58587920618301 1.57506918816933e-10 -3.31556565717047 8.68804644381516e-07 mirMAP -0.804099876932157 4.05914355054464e-10 NA NA NA hsa-miR-182-5p CACNA2D1 3.53923166221814 5.07781258121574e-21 -3.31556565717047 8.68804644381516e-07 miRNATAP -0.802351589400528 3.37596704110403e-24 NA NA NA hsa-miR-200b-3p CACNA2D1 3.78235093249346 3.18343003239465e-14 -3.31556565717047 8.68804644381516e-07 TargetScan -0.558131952404015 9.34932566571118e-20 NA NA NA hsa-miR-23a-3p CACNA2D1 1.00493340843378 2.55313889288924e-08 -3.31556565717047 8.68804644381516e-07 mirMAP -0.728701508423108 6.0457829398764e-05 NA NA NA hsa-miR-26b-5p CACNA2D1 0.885393662798425 3.2116297961629e-06 -3.31556565717047 8.68804644381516e-07 mirMAP -1.15675019556576 1.02115069413824e-11 NA NA NA hsa-miR-3065-5p CACNA2D1 2.74629919868982 1.86846589298284e-08 -3.31556565717047 8.68804644381516e-07 mirMAP -0.279071182891583 0.000598495453373106 NA NA NA hsa-miR-30d-3p CACNA2D1 0.977747550180601 4.3048212205381e-05 -3.31556565717047 8.68804644381516e-07 mirMAP -0.92428032510285 7.39868661091689e-12 NA NA NA hsa-miR-30e-3p CACNA2D1 -0.215663037684509 0.235375122783546 -3.31556565717047 8.68804644381516e-07 mirMAP -0.532160375344364 0.00390194546161315 NA NA NA hsa-miR-32-3p CACNA2D1 2.02436999565685 5.94091197945307e-09 -3.31556565717047 8.68804644381516e-07 mirMAP -0.524056657040928 6.70283139845306e-07 NA NA NA hsa-miR-330-3p CACNA2D1 0.876747334239085 0.00073709016089703 -3.31556565717047 8.68804644381516e-07 mirMAP -0.73097750778254 5.19255290752127e-09 NA NA NA hsa-miR-335-3p CACNA2D1 3.08791651139852 5.31309869723517e-12 -3.31556565717047 8.68804644381516e-07 mirMAP -0.340604402201203 1.69239744785605e-06 NA NA NA hsa-miR-33a-3p CACNA2D1 1.72765312072219 1.51784443453521e-07 -3.31556565717047 8.68804644381516e-07 mirMAP -0.402930843814106 0.000206271529316002 NA NA NA hsa-miR-362-3p CACNA2D1 2.0756816987665 3.89026064579331e-12 -3.31556565717047 8.68804644381516e-07 miRanda -0.379138984947906 0.000651376113281055 NA NA NA hsa-miR-450b-5p CACNA2D1 1.69244418548325 1.68064054148881e-10 -3.31556565717047 8.68804644381516e-07 mirMAP -0.351321354277322 0.00410187305860754 NA NA NA hsa-miR-508-3p CACNA2D1 1.05493034310846 0.0393857095042515 -3.31556565717047 8.68804644381516e-07 mirMAP -0.172707091944874 0.00869230454895343 NA NA NA hsa-miR-576-5p CACNA2D1 2.20467023993664 3.4053475193793e-19 -3.31556565717047 8.68804644381516e-07 mirMAP -1.08389391888318 2.13377876040378e-18 NA NA NA hsa-miR-590-3p CACNA2D1 2.59289455139753 1.03200520972022e-21 -3.31556565717047 8.68804644381516e-07 mirMAP -0.726424682141574 6.02713034583947e-10 NA NA NA hsa-miR-7-1-3p CACNA2D1 1.84950311431067 1.25300363397654e-13 -3.31556565717047 8.68804644381516e-07 mirMAP -0.565041660450894 1.04002683833383e-05 NA NA NA hsa-miR-944 CACNA2D1 2.91186649218281 1.31574753528144e-06 -3.31556565717047 8.68804644381516e-07 mirMAP -0.397325104652847 2.86860290506928e-13 NA NA NA hsa-miR-96-5p CACNA2D1 4.89433085814374 1.92000659886961e-31 -3.31556565717047 8.68804644381516e-07 TargetScan;miRNATAP -0.730547720605139 5.07955475272319e-25 NA NA NA hsa-miR-142-3p CACNA2D2 2.75247908790621 1.45636065474764e-12 -0.620149822610577 0.0508734108453904 miRanda -0.258045711071458 6.42282833255566e-12 NA NA NA hsa-miR-205-5p CACNA2D2 4.1389800495524 2.05488295686453e-12 -0.620149822610577 0.0508734108453904 miRNATAP -0.118620443176281 2.3583170638662e-06 NA NA NA hsa-miR-22-5p CACNA2D2 1.88011544159252 1.63978222572222e-16 -0.620149822610577 0.0508734108453904 mirMAP -0.359609083382258 2.41188250702868e-08 NA NA NA hsa-miR-34c-5p CACNA2D2 2.07190852984647 7.35776320806257e-08 -0.620149822610577 0.0508734108453904 mirMAP;miRNATAP -0.133704365593799 0.00142354180012103 NA NA NA hsa-miR-361-3p CACNA2D2 1.07367425434318 1.73142774168958e-09 -0.620149822610577 0.0508734108453904 MirTarget;PITA -0.342566438907401 5.92535695137014e-05 NA NA NA hsa-miR-3614-5p CACNA2D2 2.17736331059655 2.19144831318484e-08 -0.620149822610577 0.0508734108453904 mirMAP -0.211147089838066 1.09502846473948e-07 NA NA NA hsa-miR-455-3p CACNA2D2 3.06093594997644 3.54590649799868e-16 -0.620149822610577 0.0508734108453904 PITA;miRNATAP -0.208170862009113 9.2212808552524e-08 NA NA NA hsa-miR-429 CACNA2D3 4.48815175680773 2.44117492218206e-17 -1.0505233677206 0.0190043772864545 miRanda -0.126375833146456 0.00127281990222796 NA NA NA hsa-miR-129-5p CACNA2D4 -0.524170159980738 0.222582956006346 -0.10730947385413 0.700144543090639 miRanda;mirMAP -0.125539361302528 7.79056522277615e-05 NA NA NA hsa-miR-324-5p CACNA2D4 2.95683728155095 1.32960514360912e-20 -0.10730947385413 0.700144543090639 miRanda -0.112276571568078 0.00544190862527522 NA NA NA hsa-miR-335-3p CACNA2D4 3.08791651139852 5.31309869723517e-12 -0.10730947385413 0.700144543090639 mirMAP -0.124434501434086 1.84215249387229e-05 NA NA NA hsa-miR-335-5p CACNA2D4 1.77247705492746 2.22457658872091e-06 -0.10730947385413 0.700144543090639 miRNAWalker2_validate -0.142071458357697 5.76838810199236e-05 NA NA NA hsa-miR-429 CACNA2D4 4.48815175680773 2.44117492218206e-17 -0.10730947385413 0.700144543090639 miRanda -0.210565201707202 1.72054955709251e-19 NA NA NA hsa-let-7a-3p CACNB2 1.42015538786275 7.03375209382654e-13 -2.97276927954599 1.73108973462894e-15 MirTarget;mirMAP -0.927387566903235 2.91061955577857e-26 NA NA NA hsa-let-7b-3p CACNB2 0.868207752019623 1.30460056774366e-05 -2.97276927954599 1.73108973462894e-15 MirTarget;mirMAP -0.948902865007483 7.22033488398504e-27 NA NA NA hsa-let-7f-1-3p CACNB2 1.55054488387679 7.31326775537952e-11 -2.97276927954599 1.73108973462894e-15 MirTarget;mirMAP -0.684487940720992 2.77604420060918e-19 NA NA NA hsa-miR-103a-2-5p CACNB2 2.47599305985086 7.933028987326e-11 -2.97276927954599 1.73108973462894e-15 MirTarget -0.428735530690806 3.50718941043941e-16 NA NA NA hsa-miR-125a-3p CACNB2 1.24490295132072 5.26925231010328e-06 -2.97276927954599 1.73108973462894e-15 miRanda -0.309983736459817 4.45400930290065e-06 NA NA NA hsa-miR-144-5p CACNB2 0.195856574290527 0.61856475838049 -2.97276927954599 1.73108973462894e-15 mirMAP -0.164172984298434 0.000550001021909575 NA NA NA hsa-miR-146b-3p CACNB2 1.10569195233795 0.000660632782194023 -2.97276927954599 1.73108973462894e-15 miRNATAP -0.316521529201998 2.29540914917696e-08 NA NA NA hsa-miR-16-5p CACNB2 1.75824877145857 1.68592440033108e-16 -2.97276927954599 1.73108973462894e-15 miRNAWalker2_validate -0.971874042352817 2.39545530953528e-35 NA NA NA hsa-miR-181a-5p CACNB2 2.29556023480783 1.8138457900616e-21 -2.97276927954599 1.73108973462894e-15 miRNATAP -0.706209912816416 8.83734694285278e-24 NA NA NA hsa-miR-181b-5p CACNB2 2.49307679431293 3.92829250217627e-20 -2.97276927954599 1.73108973462894e-15 miRNATAP -0.642912040338937 6.59597409420079e-25 NA NA NA hsa-miR-181c-5p CACNB2 1.58587920618301 1.57506918816933e-10 -2.97276927954599 1.73108973462894e-15 miRNATAP -0.352448372471948 1.66545969661587e-06 NA NA NA hsa-miR-182-5p CACNB2 3.53923166221814 5.07781258121574e-21 -2.97276927954599 1.73108973462894e-15 miRNATAP -0.365172476882356 1.60928198337665e-15 NA NA NA hsa-miR-200c-5p CACNB2 2.95761105443819 3.11105707262802e-11 -2.97276927954599 1.73108973462894e-15 MirTarget;miRNATAP -0.347526072189 1.59573625844042e-16 NA NA NA hsa-miR-23a-3p CACNB2 1.00493340843378 2.55313889288924e-08 -2.97276927954599 1.73108973462894e-15 mirMAP -1.18306327857038 1.52225094811427e-35 NA NA NA hsa-miR-26b-5p CACNB2 0.885393662798425 3.2116297961629e-06 -2.97276927954599 1.73108973462894e-15 miRNAWalker2_validate;miRNATAP -0.69503222255591 4.49351704058182e-13 NA NA NA hsa-miR-27a-3p CACNB2 1.66542180327138 4.93775737894805e-13 -2.97276927954599 1.73108973462894e-15 MirTarget;miRNATAP -0.882236580932879 3.03674349924504e-33 NA NA NA hsa-miR-29a-5p CACNB2 1.46749674755271 3.34605004270294e-07 -2.97276927954599 1.73108973462894e-15 MirTarget -0.556519216217619 2.22748838039932e-17 NA NA NA hsa-miR-30e-5p CACNB2 1.23904909539663 1.35561917122157e-09 -2.97276927954599 1.73108973462894e-15 MirTarget;miRNATAP -0.520797660260297 5.35220925921051e-09 NA NA NA hsa-miR-31-5p CACNB2 3.59165123035072 2.27423212057482e-07 -2.97276927954599 1.73108973462894e-15 MirTarget;miRNATAP -0.279075661952428 7.35461331382271e-26 NA NA NA hsa-miR-32-3p CACNB2 2.02436999565685 5.94091197945307e-09 -2.97276927954599 1.73108973462894e-15 mirMAP;miRNATAP -0.335412307067586 1.73382224912476e-08 NA NA NA hsa-miR-339-5p CACNB2 2.68710938429893 3.03134080808154e-16 -2.97276927954599 1.73108973462894e-15 miRNATAP -0.476677051570318 1.24224339345313e-19 NA NA NA hsa-miR-34c-5p CACNB2 2.07190852984647 7.35776320806257e-08 -2.97276927954599 1.73108973462894e-15 miRanda -0.353466584467561 1.34955299415966e-12 NA NA NA hsa-miR-361-5p CACNB2 0.971859117235239 5.30236555707088e-09 -2.97276927954599 1.73108973462894e-15 miRanda -0.739142905502916 1.69328972536458e-11 NA NA NA hsa-miR-3653-3p CACNB2 1.85886928622326 2.98407490336841e-08 -2.97276927954599 1.73108973462894e-15 MirTarget -0.394136173331256 4.08639368131369e-12 NA NA NA hsa-miR-429 CACNB2 4.48815175680773 2.44117492218206e-17 -2.97276927954599 1.73108973462894e-15 PITA;miRanda;miRNATAP -0.174734898270875 1.81132777894872e-07 NA NA NA hsa-miR-550a-3p CACNB2 1.78308792532884 2.47673569057582e-07 -2.97276927954599 1.73108973462894e-15 MirTarget;miRNATAP -0.558153791192758 3.95709724959462e-22 NA NA NA hsa-miR-590-3p CACNB2 2.59289455139753 1.03200520972022e-21 -2.97276927954599 1.73108973462894e-15 mirMAP -0.720904725867605 2.97435659278327e-30 NA NA NA hsa-miR-592 CACNB2 1.51765968871077 0.000636335248013204 -2.97276927954599 1.73108973462894e-15 PITA -0.220224084376161 1.80926959454849e-07 NA NA NA hsa-miR-628-5p CACNB2 0.799263053510813 2.28892357418044e-05 -2.97276927954599 1.73108973462894e-15 MirTarget;PITA;miRNATAP -0.605181067157446 6.27705691036878e-10 NA NA NA hsa-miR-7-1-3p CACNB2 1.84950311431067 1.25300363397654e-13 -2.97276927954599 1.73108973462894e-15 mirMAP -0.655769838746232 5.56720988375134e-21 NA NA NA hsa-miR-874-3p CACNB2 1.95617235160298 2.0152613104032e-12 -2.97276927954599 1.73108973462894e-15 MirTarget -0.413156364262865 1.4350138859457e-10 NA NA NA hsa-miR-9-5p CACNB2 1.02304182473283 0.042901377604859 -2.97276927954599 1.73108973462894e-15 MirTarget;miRNATAP -0.129021393469885 0.000462309369433168 NA NA NA hsa-miR-93-3p CACNB2 2.85383869771942 5.64481766902125e-23 -2.97276927954599 1.73108973462894e-15 MirTarget;miRNATAP -0.560651140014914 9.6793728057865e-22 NA NA NA hsa-miR-96-5p CACNB2 4.89433085814374 1.92000659886961e-31 -2.97276927954599 1.73108973462894e-15 miRNATAP -0.35822029593489 1.48456107973879e-18 NA NA NA hsa-miR-150-5p CACNB3 -0.105827294491332 0.799351458244375 1.08302139474868 1.15459671564098e-06 miRNATAP -0.137904974181474 9.76297568409693e-08 NA NA NA hsa-let-7a-5p CACNB4 0.618599506841644 2.76973453058748e-05 -2.87454559120761 1.1475342642129e-10 TargetScan;miRNATAP -0.845284449782234 1.603787640219e-08 NA NA NA hsa-let-7b-5p CACNB4 0.604314269683977 0.00140009936153214 -2.87454559120761 1.1475342642129e-10 miRNATAP -0.704655607925373 1.09311509095521e-09 NA NA NA hsa-let-7d-5p CACNB4 1.33236798905207 1.1741085658466e-13 -2.87454559120761 1.1475342642129e-10 miRNATAP -0.839817300752963 1.03092084167204e-12 NA NA NA hsa-let-7f-5p CACNB4 0.495648727272215 0.00355972741198794 -2.87454559120761 1.1475342642129e-10 miRNATAP -0.367387446394503 0.00521198931304208 NA NA NA hsa-let-7g-3p CACNB4 3.26398061402445 3.96263126107645e-25 -2.87454559120761 1.1475342642129e-10 miRNATAP -0.538131023685762 2.18411035789844e-16 NA NA NA hsa-let-7g-5p CACNB4 1.20061455355116 1.50237505511483e-12 -2.87454559120761 1.1475342642129e-10 miRNATAP -0.532497602594181 3.09420169644257e-05 NA NA NA hsa-let-7i-5p CACNB4 0.412877696970403 0.00622731051981756 -2.87454559120761 1.1475342642129e-10 miRNATAP -0.414811044099898 0.0054063127751309 NA NA NA hsa-miR-107 CACNB4 1.30977326593435 1.30372468603965e-11 -2.87454559120761 1.1475342642129e-10 miRanda -0.694558166827133 3.14692879791205e-10 NA NA NA hsa-miR-126-5p CACNB4 0.895338176458417 2.33372756450713e-05 -2.87454559120761 1.1475342642129e-10 mirMAP -0.393764109852071 0.000150478551996123 NA NA NA hsa-miR-129-5p CACNB4 -0.524170159980738 0.222582956006346 -2.87454559120761 1.1475342642129e-10 PITA;miRanda;miRNATAP -0.136197583292828 0.0093635753927653 NA NA NA hsa-miR-132-3p CACNB4 0.156276992635384 0.408190812100704 -2.87454559120761 1.1475342642129e-10 miRNATAP -0.455492993315046 0.000112429978352445 NA NA NA hsa-miR-142-5p CACNB4 1.17581605694506 0.0018174701991234 -2.87454559120761 1.1475342642129e-10 mirMAP -0.205277223282294 0.00041387725486767 NA NA NA hsa-miR-144-3p CACNB4 0.658119849508907 0.146943823997989 -2.87454559120761 1.1475342642129e-10 mirMAP -0.185695421405705 0.000204238394984395 NA NA NA hsa-miR-146b-5p CACNB4 1.75587235896724 1.15724631266659e-07 -2.87454559120761 1.1475342642129e-10 miRanda -0.268509869468307 3.99455983863919e-05 NA NA NA hsa-miR-155-5p CACNB4 1.20164021433135 0.00086170622431261 -2.87454559120761 1.1475342642129e-10 mirMAP;miRNATAP -0.248193852971588 4.21350433274051e-05 NA NA NA hsa-miR-15a-5p CACNB4 2.34669284378787 1.69544424500258e-23 -2.87454559120761 1.1475342642129e-10 miRNATAP -0.606061663331098 3.79808839087551e-12 NA NA NA hsa-miR-15b-3p CACNB4 2.33847028227712 4.29662877950836e-19 -2.87454559120761 1.1475342642129e-10 mirMAP -0.727188305388378 4.58413457369051e-21 NA NA NA hsa-miR-15b-5p CACNB4 1.57112623124278 9.14247846750597e-13 -2.87454559120761 1.1475342642129e-10 miRNATAP -0.836373052143019 7.60374731782395e-19 NA NA NA hsa-miR-16-1-3p CACNB4 2.56983217111073 3.02262181237943e-20 -2.87454559120761 1.1475342642129e-10 mirMAP -0.490703936825541 1.27090118680284e-10 NA NA NA hsa-miR-16-5p CACNB4 1.75824877145857 1.68592440033108e-16 -2.87454559120761 1.1475342642129e-10 miRNATAP -0.796563525982311 2.19922220993769e-16 NA NA NA hsa-miR-181a-5p CACNB4 2.29556023480783 1.8138457900616e-21 -2.87454559120761 1.1475342642129e-10 mirMAP -0.675119210397874 1.49371546435188e-15 NA NA NA hsa-miR-181b-5p CACNB4 2.49307679431293 3.92829250217627e-20 -2.87454559120761 1.1475342642129e-10 mirMAP -0.598003662930905 2.18766093957309e-15 NA NA NA hsa-miR-181c-5p CACNB4 1.58587920618301 1.57506918816933e-10 -2.87454559120761 1.1475342642129e-10 mirMAP -0.394715181967774 5.53578427098837e-06 NA NA NA hsa-miR-182-5p CACNB4 3.53923166221814 5.07781258121574e-21 -2.87454559120761 1.1475342642129e-10 miRNATAP -0.316604534485063 8.60776206418429e-09 NA NA NA hsa-miR-183-5p CACNB4 4.19757025992371 4.79612296318304e-26 -2.87454559120761 1.1475342642129e-10 miRNATAP -0.336089714578637 4.55419449150217e-11 NA NA NA hsa-miR-196a-5p CACNB4 1.52993069622497 0.00397268663639603 -2.87454559120761 1.1475342642129e-10 miRNATAP -0.152300332460308 0.000221373938229996 NA NA NA hsa-miR-196b-5p CACNB4 1.71646270856386 4.37735885910369e-09 -2.87454559120761 1.1475342642129e-10 miRNATAP -0.365721871360363 6.59485622732452e-07 NA NA NA hsa-miR-20a-3p CACNB4 2.92621109947706 2.49504904635375e-17 -2.87454559120761 1.1475342642129e-10 miRNATAP -0.460135807984681 6.28799473999216e-14 NA NA NA hsa-miR-212-3p CACNB4 0.357878936470387 0.232446214501331 -2.87454559120761 1.1475342642129e-10 miRNATAP -0.230975595473043 0.00186683957160069 NA NA NA hsa-miR-221-3p CACNB4 0.451556679024397 0.0909808299917811 -2.87454559120761 1.1475342642129e-10 miRNATAP -0.358304936508339 1.37452064442168e-05 NA NA NA hsa-miR-222-3p CACNB4 0.851783756239071 0.00266783568486918 -2.87454559120761 1.1475342642129e-10 miRNATAP -0.450593845391957 3.98468033971857e-09 NA NA NA hsa-miR-25-3p CACNB4 1.36472605225697 4.83790725935681e-11 -2.87454559120761 1.1475342642129e-10 mirMAP -0.534389466490555 2.54464033073787e-07 NA NA NA hsa-miR-26b-5p CACNB4 0.885393662798425 3.2116297961629e-06 -2.87454559120761 1.1475342642129e-10 miRNAWalker2_validate;miRNATAP -0.476275233773716 3.77354109718421e-05 NA NA NA hsa-miR-29a-5p CACNB4 1.46749674755271 3.34605004270294e-07 -2.87454559120761 1.1475342642129e-10 mirMAP -0.573870194362461 2.14147967380102e-13 NA NA NA hsa-miR-29b-1-5p CACNB4 1.55384379072167 4.76870585070176e-05 -2.87454559120761 1.1475342642129e-10 mirMAP -0.484653744336387 1.50716693710411e-16 NA NA NA hsa-miR-3065-5p CACNB4 2.74629919868982 1.86846589298284e-08 -2.87454559120761 1.1475342642129e-10 mirMAP -0.281588034271811 1.68787893828411e-07 NA NA NA hsa-miR-30e-5p CACNB4 1.23904909539663 1.35561917122157e-09 -2.87454559120761 1.1475342642129e-10 mirMAP -0.399902356556947 0.000172710083397832 NA NA NA hsa-miR-32-3p CACNB4 2.02436999565685 5.94091197945307e-09 -2.87454559120761 1.1475342642129e-10 mirMAP;miRNATAP -0.279954496473516 7.74734699760752e-05 NA NA NA hsa-miR-32-5p CACNB4 2.34056473219422 6.24134585974322e-20 -2.87454559120761 1.1475342642129e-10 mirMAP -0.51795934294653 1.63571420844063e-10 NA NA NA hsa-miR-320b CACNB4 1.55692969039548 1.41071034251915e-08 -2.87454559120761 1.1475342642129e-10 PITA;miRanda -0.486284617824818 4.25805634155841e-10 NA NA NA hsa-miR-330-3p CACNB4 0.876747334239085 0.00073709016089703 -2.87454559120761 1.1475342642129e-10 mirMAP -0.282533090118941 0.000858328811093357 NA NA NA hsa-miR-335-3p CACNB4 3.08791651139852 5.31309869723517e-12 -2.87454559120761 1.1475342642129e-10 mirMAP -0.230997876652841 1.16905351284019e-06 NA NA NA hsa-miR-338-3p CACNB4 0.453166438193782 0.144583389707558 -2.87454559120761 1.1475342642129e-10 PITA;miRanda;miRNATAP -0.189495375638961 0.00782360459984238 NA NA NA hsa-miR-338-5p CACNB4 -0.577691606146419 0.0472212680542825 -2.87454559120761 1.1475342642129e-10 mirMAP;miRNATAP -0.202435524318606 0.00828394657084676 NA NA NA hsa-miR-33a-3p CACNB4 1.72765312072219 1.51784443453521e-07 -2.87454559120761 1.1475342642129e-10 miRNATAP -0.256495311934687 0.000410998925517916 NA NA NA hsa-miR-342-3p CACNB4 1.49115144672245 1.43879249744621e-07 -2.87454559120761 1.1475342642129e-10 miRanda -0.212172391788218 0.00584650454574703 NA NA NA hsa-miR-34c-3p CACNB4 2.41359195938096 3.46966584087088e-10 -2.87454559120761 1.1475342642129e-10 mirMAP -0.32011796583605 2.55222330659302e-08 NA NA NA hsa-miR-361-5p CACNB4 0.971859117235239 5.30236555707088e-09 -2.87454559120761 1.1475342642129e-10 miRanda;mirMAP -0.669802246398535 3.14449621748518e-07 NA NA NA hsa-miR-421 CACNB4 1.17791565395543 6.78526676976629e-06 -2.87454559120761 1.1475342642129e-10 PITA;miRanda;miRNATAP -0.348451837131869 3.04507576733377e-05 NA NA NA hsa-miR-424-5p CACNB4 1.61930224569578 1.89642549274994e-10 -2.87454559120761 1.1475342642129e-10 miRNATAP -0.435834378104806 2.40643119239266e-07 NA NA NA hsa-miR-429 CACNB4 4.48815175680773 2.44117492218206e-17 -2.87454559120761 1.1475342642129e-10 PITA;miRanda;miRNATAP -0.179015812367822 6.32898604147121e-06 NA NA NA hsa-miR-455-5p CACNB4 2.2582442061694 1.43472128037398e-13 -2.87454559120761 1.1475342642129e-10 PITA;miRanda;miRNATAP -0.565120377368422 7.4269802370861e-17 NA NA NA hsa-miR-505-3p CACNB4 1.45322244209148 8.86597629645867e-10 -2.87454559120761 1.1475342642129e-10 miRNATAP -0.676124505333632 3.31172701396688e-14 NA NA NA hsa-miR-532-5p CACNB4 1.55697650978597 1.57884735535196e-11 -2.87454559120761 1.1475342642129e-10 miRNATAP -0.439536461695208 2.30018036969258e-06 NA NA NA hsa-miR-539-5p CACNB4 0.95216780650456 0.00284373332122135 -2.87454559120761 1.1475342642129e-10 mirMAP -0.188652414012272 0.00662042180977645 NA NA NA hsa-miR-550a-3p CACNB4 1.78308792532884 2.47673569057582e-07 -2.87454559120761 1.1475342642129e-10 miRNATAP -0.601452174134139 2.0701203629222e-18 NA NA NA hsa-miR-589-3p CACNB4 2.51971841868825 2.39125940264107e-11 -2.87454559120761 1.1475342642129e-10 mirMAP -0.426919246594788 2.01731882544532e-11 NA NA NA hsa-miR-590-3p CACNB4 2.59289455139753 1.03200520972022e-21 -2.87454559120761 1.1475342642129e-10 miRanda;mirMAP;miRNATAP -0.625292541303065 5.4349749108593e-16 NA NA NA hsa-miR-708-3p CACNB4 2.80907765282502 3.07460722669281e-14 -2.87454559120761 1.1475342642129e-10 mirMAP -0.206250488095919 0.000345479390335939 NA NA NA hsa-miR-92a-3p CACNB4 2.06460102658973 1.44784291084757e-19 -2.87454559120761 1.1475342642129e-10 mirMAP -0.815349274452446 5.03622961136084e-20 NA NA NA hsa-miR-92b-3p CACNB4 1.20409245530001 3.41055816361655e-06 -2.87454559120761 1.1475342642129e-10 mirMAP -0.458788837487653 3.87957172020487e-08 NA NA NA hsa-miR-944 CACNB4 2.91186649218281 1.31574753528144e-06 -2.87454559120761 1.1475342642129e-10 PITA;mirMAP -0.189420792985012 2.94062624891921e-07 NA NA NA hsa-miR-96-5p CACNB4 4.89433085814374 1.92000659886961e-31 -2.87454559120761 1.1475342642129e-10 TargetScan;miRNATAP -0.3118622195555 2.11320655431347e-10 NA NA NA hsa-let-7a-3p CACNG4 1.42015538786275 7.03375209382654e-13 1.1306096823056 0.16231360867352 MirTarget -0.537231931528505 0.00570729170880025 NA NA NA hsa-miR-3614-5p CACNG4 2.17736331059655 2.19144831318484e-08 1.1306096823056 0.16231360867352 mirMAP -0.307580415615135 0.0026697513286458 NA NA NA hsa-miR-582-3p CACNG4 0.00876844181512659 0.977126166214707 1.1306096823056 0.16231360867352 miRNATAP -0.375342909689063 0.00346676471075502 NA NA NA hsa-miR-335-5p CD14 1.77247705492746 2.22457658872091e-06 -0.500765821103562 0.237403961708929 miRNAWalker2_validate -0.283820663765675 1.08156802465561e-07 NA NA NA hsa-miR-491-5p CD14 0.615770352820862 0.0418295628761654 -0.500765821103562 0.237403961708929 miRanda -0.201224600902803 0.00567338925170913 NA NA NA hsa-miR-141-3p CDC25B 5.02396127982626 2.19224509139725e-24 0.783166040527924 0.00478680511553999 TargetScan -0.118085231335799 3.69707768792997e-06 NA NA NA hsa-miR-429 CDC25B 4.48815175680773 2.44117492218206e-17 0.783166040527924 0.00478680511553999 miRanda -0.194288018952407 1.45177267683282e-16 NA NA NA hsa-miR-29b-2-5p CHUK 0.910668640983475 0.00666655585493488 -0.123960303858583 0.302722046952969 MirTarget -0.105463511044412 4.36313837727314e-10 NA NA NA hsa-miR-497-5p CHUK 0.0257087130056286 0.918145413833358 -0.123960303858583 0.302722046952969 MirTarget -0.130303574602807 1.33264117705817e-08 NA NA NA hsa-let-7g-5p CRK 1.20061455355116 1.50237505511483e-12 -0.602280866864171 4.11131295616185e-05 miRNATAP -0.109438703416958 0.00850560752555828 NA NA NA hsa-let-7i-5p CRK 0.412877696970403 0.00622731051981756 -0.602280866864171 4.11131295616185e-05 miRNATAP -0.133917081803886 0.00549112360682744 NA NA NA hsa-miR-125a-5p CRK 0.599529391575274 0.0102300147180307 -0.602280866864171 4.11131295616185e-05 miRNAWalker2_validate -0.134944175246404 9.66088208277703e-06 NA NA NA hsa-miR-186-5p CRK 1.47445398888668 3.0781726595413e-15 -0.602280866864171 4.11131295616185e-05 miRNATAP -0.126409187359572 0.000691628455609533 NA NA NA hsa-miR-30c-5p CRK 0.778774633108 0.000285599212429136 -0.602280866864171 4.11131295616185e-05 miRNATAP -0.167750511926807 3.66674808118506e-07 NA NA NA hsa-miR-362-3p CRK 2.0756816987665 3.89026064579331e-12 -0.602280866864171 4.11131295616185e-05 miRanda -0.114922361146032 1.47529903884979e-06 NA NA NA hsa-let-7e-5p DUSP1 0.860104282510173 6.04758298373779e-05 -3.47418646928724 1.98436002754553e-20 miRNATAP -0.299363156756553 0.000734997664902812 NA NA NA hsa-let-7f-5p DUSP1 0.495648727272215 0.00355972741198794 -3.47418646928724 1.98436002754553e-20 miRNATAP -0.406806899552649 0.000321998780945857 NA NA NA hsa-let-7g-5p DUSP1 1.20061455355116 1.50237505511483e-12 -3.47418646928724 1.98436002754553e-20 miRNATAP -0.797552159903443 1.42817130370134e-13 NA NA NA hsa-miR-141-3p DUSP1 5.02396127982626 2.19224509139725e-24 -3.47418646928724 1.98436002754553e-20 TargetScan -0.341619784247028 4.31538999884695e-23 NA NA NA hsa-miR-186-5p DUSP1 1.47445398888668 3.0781726595413e-15 -3.47418646928724 1.98436002754553e-20 mirMAP -0.695608991290807 7.75743213786348e-13 NA NA NA hsa-miR-200b-3p DUSP1 3.78235093249346 3.18343003239465e-14 -3.47418646928724 1.98436002754553e-20 MirTarget;TargetScan -0.32528620603311 3.30976596849034e-20 NA NA NA hsa-miR-200c-3p DUSP1 3.50132673580082 2.42716349086937e-15 -3.47418646928724 1.98436002754553e-20 MirTarget;miRNATAP -0.31571143226552 4.3503827266648e-15 NA NA NA hsa-miR-26b-5p DUSP1 0.885393662798425 3.2116297961629e-06 -3.47418646928724 1.98436002754553e-20 miRNAWalker2_validate -0.36876602468636 0.000222882039128576 NA NA NA hsa-miR-324-3p DUSP1 2.08739139768981 3.11885987067952e-13 -3.47418646928724 1.98436002754553e-20 MirTarget -0.595544666777794 4.13974140938739e-22 NA NA NA hsa-miR-331-5p DUSP1 2.17414714166315 1.54547681391888e-18 -3.47418646928724 1.98436002754553e-20 PITA;miRNATAP -0.673177403922591 2.19034183385445e-20 NA NA NA hsa-miR-34a-3p DUSP1 1.75590866103657 8.02801510630657e-09 -3.47418646928724 1.98436002754553e-20 MirTarget -0.384933267542239 1.17086840216167e-08 NA NA NA hsa-miR-425-3p DUSP1 2.44475111851934 3.07357782121102e-18 -3.47418646928724 1.98436002754553e-20 MirTarget -0.65621244903209 9.62828624543705e-27 NA NA NA hsa-miR-429 DUSP1 4.48815175680773 2.44117492218206e-17 -3.47418646928724 1.98436002754553e-20 MirTarget;PITA;miRanda;miRNATAP -0.326106768941407 1.81178985946822e-23 NA NA NA hsa-miR-194-5p DUSP10 1.8992998339217 3.76507853301977e-10 0.000920025183515083 0.997792983773082 miRNATAP -0.156284967722718 0.00261176652743425 NA NA NA hsa-miR-25-3p DUSP10 1.36472605225697 4.83790725935681e-11 0.000920025183515083 0.997792983773082 MirTarget;miRNATAP -0.198013379680032 0.00948099320662584 NA NA NA hsa-miR-32-5p DUSP10 2.34056473219422 6.24134585974322e-20 0.000920025183515083 0.997792983773082 MirTarget;miRNATAP -0.21161459623965 0.000416198553248812 NA NA NA hsa-miR-421 DUSP10 1.17791565395543 6.78526676976629e-06 0.000920025183515083 0.997792983773082 PITA;miRanda;miRNATAP -0.180101743634852 0.00321049447760203 NA NA NA hsa-miR-98-5p DUSP10 1.11154309866014 1.24143909012085e-08 0.000920025183515083 0.997792983773082 miRNAWalker2_validate -0.296259589544549 0.000277836147323921 NA NA NA hsa-miR-26b-5p DUSP14 0.885393662798425 3.2116297961629e-06 -0.283367076699289 0.153931415544578 miRNAWalker2_validate -0.136039189585562 0.00709634159548101 NA NA NA hsa-miR-320a DUSP14 0.438165828017084 0.0390159073347133 -0.283367076699289 0.153931415544578 miRanda -0.185279204737427 4.35450744952231e-05 NA NA NA hsa-let-7a-5p DUSP22 0.618599506841644 2.76973453058748e-05 -0.785516192242289 7.28024672517459e-07 TargetScan -0.141040804119291 0.00812887716125449 NA NA NA hsa-miR-1226-3p DUSP22 1.38118928579963 0.000205503474787488 -0.785516192242289 7.28024672517459e-07 MirTarget -0.131947978779123 1.59902737993898e-08 NA NA NA hsa-miR-28-5p DUSP22 0.230152919654905 0.0742909586754846 -0.785516192242289 7.28024672517459e-07 miRanda -0.217237303139145 0.000447910069379617 NA NA NA hsa-miR-320a DUSP22 0.438165828017084 0.0390159073347133 -0.785516192242289 7.28024672517459e-07 miRanda -0.129812132190189 0.000403096684457747 NA NA NA hsa-miR-320b DUSP22 1.55692969039548 1.41071034251915e-08 -0.785516192242289 7.28024672517459e-07 miRanda -0.153135241463841 2.45918228347565e-08 NA NA NA hsa-miR-335-5p DUSP22 1.77247705492746 2.22457658872091e-06 -0.785516192242289 7.28024672517459e-07 miRNAWalker2_validate -0.101075844520081 5.92139443062124e-07 NA NA NA hsa-miR-590-3p DUSP22 2.59289455139753 1.03200520972022e-21 -0.785516192242289 7.28024672517459e-07 mirMAP -0.138740699505101 5.69720376941923e-07 NA NA NA hsa-miR-744-3p DUSP22 2.7517405670917 4.22040908411227e-14 -0.785516192242289 7.28024672517459e-07 mirMAP -0.143530358612051 9.1725756309612e-13 NA NA NA hsa-miR-96-5p DUSP22 4.89433085814374 1.92000659886961e-31 -0.785516192242289 7.28024672517459e-07 TargetScan -0.113205885745919 4.66955209084352e-11 NA NA NA hsa-miR-103a-2-5p DUSP3 2.47599305985086 7.933028987326e-11 -1.04472877082381 6.16231013810421e-12 MirTarget -0.110332357679281 3.37871083342078e-07 NA NA NA hsa-miR-10a-5p DUSP3 1.15016989191194 0.00372037233992369 -1.04472877082381 6.16231013810421e-12 miRNAWalker2_validate -0.110964365267517 2.38781829302925e-09 NA NA NA hsa-miR-125a-5p DUSP3 0.599529391575274 0.0102300147180307 -1.04472877082381 6.16231013810421e-12 miRNAWalker2_validate -0.187985131427737 3.57029320961441e-09 NA NA NA hsa-miR-126-5p DUSP3 0.895338176458417 2.33372756450713e-05 -1.04472877082381 6.16231013810421e-12 mirMAP -0.160143190406292 5.61118670238911e-06 NA NA NA hsa-miR-1266-5p DUSP3 1.3763848124288 0.000876906064212958 -1.04472877082381 6.16231013810421e-12 MirTarget -0.112588723898196 2.8399706590981e-10 NA NA NA hsa-miR-130b-5p DUSP3 2.9963110846538 1.98883029416455e-18 -1.04472877082381 6.16231013810421e-12 MirTarget -0.196322334667211 1.88345096320268e-21 NA NA NA hsa-miR-141-3p DUSP3 5.02396127982626 2.19224509139725e-24 -1.04472877082381 6.16231013810421e-12 MirTarget;TargetScan;miRNATAP -0.153679233077013 1.48438763140924e-30 NA NA NA hsa-miR-15a-5p DUSP3 2.34669284378787 1.69544424500258e-23 -1.04472877082381 6.16231013810421e-12 MirTarget;miRNATAP -0.260461867624511 4.72219586060628e-19 NA NA NA hsa-miR-15b-5p DUSP3 1.57112623124278 9.14247846750597e-13 -1.04472877082381 6.16231013810421e-12 MirTarget;miRNATAP -0.286227523726624 5.20105453576124e-19 NA NA NA hsa-miR-16-5p DUSP3 1.75824877145857 1.68592440033108e-16 -1.04472877082381 6.16231013810421e-12 MirTarget;miRNATAP -0.275700614346834 6.76245358310024e-17 NA NA NA hsa-miR-182-5p DUSP3 3.53923166221814 5.07781258121574e-21 -1.04472877082381 6.16231013810421e-12 mirMAP -0.216653786785627 3.30809852131513e-35 NA NA NA hsa-miR-186-5p DUSP3 1.47445398888668 3.0781726595413e-15 -1.04472877082381 6.16231013810421e-12 mirMAP -0.319617294134481 3.44572069773868e-17 NA NA NA hsa-miR-197-3p DUSP3 1.75733174019505 8.88576793100499e-13 -1.04472877082381 6.16231013810421e-12 mirMAP -0.194923995098165 2.7078022780967e-11 NA NA NA hsa-miR-200a-3p DUSP3 4.59434485520731 6.38952518573476e-18 -1.04472877082381 6.16231013810421e-12 MirTarget;miRNATAP -0.161254083403431 3.26337884340941e-39 NA NA NA hsa-miR-28-5p DUSP3 0.230152919654905 0.0742909586754846 -1.04472877082381 6.16231013810421e-12 mirMAP -0.230354286210765 0.000123198018898744 NA NA NA hsa-miR-30d-3p DUSP3 0.977747550180601 4.3048212205381e-05 -1.04472877082381 6.16231013810421e-12 mirMAP -0.250379278871646 1.58321533248443e-16 NA NA NA hsa-miR-30e-3p DUSP3 -0.215663037684509 0.235375122783546 -1.04472877082381 6.16231013810421e-12 mirMAP -0.278979924765578 1.09010975302132e-11 NA NA NA hsa-miR-3127-5p DUSP3 1.51846438737133 3.59571251672767e-07 -1.04472877082381 6.16231013810421e-12 MirTarget -0.161370077148719 3.79457637537592e-11 NA NA NA hsa-miR-320a DUSP3 0.438165828017084 0.0390159073347133 -1.04472877082381 6.16231013810421e-12 mirMAP -0.27445413293545 2.08356190937694e-15 NA NA NA hsa-miR-320b DUSP3 1.55692969039548 1.41071034251915e-08 -1.04472877082381 6.16231013810421e-12 mirMAP -0.202591431203834 1.10142806388598e-14 NA NA NA hsa-miR-361-5p DUSP3 0.971859117235239 5.30236555707088e-09 -1.04472877082381 6.16231013810421e-12 miRNAWalker2_validate;miRanda -0.435412615761459 1.83775689535804e-24 NA NA NA hsa-miR-3913-5p DUSP3 2.44353493655328 8.95279496632448e-15 -1.04472877082381 6.16231013810421e-12 MirTarget -0.235886312753144 7.4904399900709e-26 NA NA NA hsa-miR-421 DUSP3 1.17791565395543 6.78526676976629e-06 -1.04472877082381 6.16231013810421e-12 miRNAWalker2_validate -0.125887950718521 9.55325168359982e-06 NA NA NA hsa-miR-429 DUSP3 4.48815175680773 2.44117492218206e-17 -1.04472877082381 6.16231013810421e-12 miRNATAP -0.162537985400869 2.56776004463461e-39 NA NA NA hsa-miR-484 DUSP3 1.81844463411787 1.82951571230938e-15 -1.04472877082381 6.16231013810421e-12 mirMAP -0.278851285171467 7.95384813286986e-20 NA NA NA hsa-miR-590-3p DUSP3 2.59289455139753 1.03200520972022e-21 -1.04472877082381 6.16231013810421e-12 MirTarget;miRanda;mirMAP -0.186381942262881 2.22181177299252e-12 NA NA NA hsa-miR-708-5p DUSP3 3.38051631555486 5.12590198690777e-18 -1.04472877082381 6.16231013810421e-12 mirMAP -0.119082024648545 4.39781330963206e-11 NA NA NA hsa-miR-193a-3p DUSP4 1.60460546928078 2.86169793322984e-07 -0.553674836164674 0.121037429306323 mirMAP -0.140999551914163 0.00983156604033444 NA NA NA hsa-miR-181c-5p DUSP5 1.58587920618301 1.57506918816933e-10 -1.96829039841284 2.18733446918558e-08 miRNATAP -0.20274810899757 0.00310970109356186 NA NA NA hsa-miR-25-3p DUSP5 1.36472605225697 4.83790725935681e-11 -1.96829039841284 2.18733446918558e-08 MirTarget;miRNATAP -0.33868384712119 3.39936241184058e-05 NA NA NA hsa-miR-324-5p DUSP5 2.95683728155095 1.32960514360912e-20 -1.96829039841284 2.18733446918558e-08 miRanda -0.235893529137662 4.73041303795146e-06 NA NA NA hsa-miR-331-3p DUSP5 2.28379581858927 1.99663919173155e-18 -1.96829039841284 2.18733446918558e-08 MirTarget;miRNATAP -0.257753844643743 4.91731935679242e-05 NA NA NA hsa-miR-363-3p DUSP5 1.50575300026701 0.00020976164678918 -1.96829039841284 2.18733446918558e-08 MirTarget -0.171215656455567 4.80739135821854e-05 NA NA NA hsa-miR-590-5p DUSP5 3.18300989862077 2.06813568597893e-26 -1.96829039841284 2.18733446918558e-08 PITA;miRanda;miRNATAP -0.166208147545032 0.00290620645051229 NA NA NA hsa-miR-92a-3p DUSP5 2.06460102658973 1.44784291084757e-19 -1.96829039841284 2.18733446918558e-08 MirTarget;miRNATAP -0.296931445901779 4.23215704961429e-05 NA NA NA hsa-miR-92b-3p DUSP5 1.20409245530001 3.41055816361655e-06 -1.96829039841284 2.18733446918558e-08 MirTarget;miRNATAP -0.218867120446703 0.000941066196127522 NA NA NA hsa-miR-342-3p DUSP6 1.49115144672245 1.43879249744621e-07 -0.400194587052505 0.171488713470446 PITA;miRanda -0.204233650547802 3.12630544123288e-05 NA NA NA hsa-miR-107 DUSP7 1.30977326593435 1.30372468603965e-11 0.251956742030193 0.415548070412105 miRanda -0.221868954193808 0.00356953466862555 NA NA NA hsa-miR-10a-5p DUSP7 1.15016989191194 0.00372037233992369 0.251956742030193 0.415548070412105 mirMAP -0.118890321257816 0.00152510431759678 NA NA NA hsa-miR-125a-5p DUSP7 0.599529391575274 0.0102300147180307 0.251956742030193 0.415548070412105 miRanda -0.252487441058183 8.00110477560952e-05 NA NA NA hsa-miR-200b-3p DUSP7 3.78235093249346 3.18343003239465e-14 0.251956742030193 0.415548070412105 TargetScan -0.131626510982377 4.79792601423783e-06 NA NA NA hsa-miR-29c-3p DUSP7 -0.00968972577705429 0.97099586346872 0.251956742030193 0.415548070412105 mirMAP -0.227513166047293 5.04062372091396e-05 NA NA NA hsa-miR-3200-3p DUSP7 2.70510522077868 1.90469509928484e-08 0.251956742030193 0.415548070412105 mirMAP -0.179627116348571 1.94204635602447e-08 NA NA NA hsa-miR-326 DUSP7 0.715313016136042 0.0610265683213359 0.251956742030193 0.415548070412105 miRanda;mirMAP -0.25125230170386 6.89930355608225e-11 NA NA NA hsa-miR-335-5p DUSP7 1.77247705492746 2.22457658872091e-06 0.251956742030193 0.415548070412105 mirMAP -0.138697867709391 0.000422271673351041 NA NA NA hsa-miR-345-5p DUSP7 3.63532310411307 2.2698112107996e-21 0.251956742030193 0.415548070412105 mirMAP -0.145852666839742 7.83280679100116e-05 NA NA NA hsa-miR-362-5p DUSP7 1.59303749908759 9.582675908797e-08 0.251956742030193 0.415548070412105 mirMAP -0.26281327140013 7.25935539976836e-08 NA NA NA hsa-miR-421 DUSP7 1.17791565395543 6.78526676976629e-06 0.251956742030193 0.415548070412105 mirMAP -0.160170474303481 0.00488240042465467 NA NA NA hsa-miR-429 DUSP7 4.48815175680773 2.44117492218206e-17 0.251956742030193 0.415548070412105 miRanda;miRNATAP -0.126985601108761 2.19007180557901e-06 NA NA NA hsa-miR-532-3p DUSP7 1.96631878320218 4.53421954361695e-13 0.251956742030193 0.415548070412105 mirMAP -0.152898240001147 0.00436589609648947 NA NA NA hsa-miR-93-3p DUSP7 2.85383869771942 5.64481766902125e-23 0.251956742030193 0.415548070412105 mirMAP -0.159205125628175 0.00115557304326708 NA NA NA hsa-miR-106a-5p DUSP8 2.48882002962836 1.99757727374521e-12 -2.17002902781112 4.33786956113647e-11 MirTarget;miRNATAP -0.171366168804113 0.000125708868957992 NA NA NA hsa-miR-106b-5p DUSP8 2.46782146831112 1.36171495805632e-23 -2.17002902781112 4.33786956113647e-11 MirTarget;miRNATAP -0.410896225236437 2.36798161212342e-11 NA NA NA hsa-miR-1226-3p DUSP8 1.38118928579963 0.000205503474787488 -2.17002902781112 4.33786956113647e-11 mirMAP -0.18969697903723 0.000133018663652407 NA NA NA hsa-miR-130b-3p DUSP8 3.5350292994509 1.73934183852569e-27 -2.17002902781112 4.33786956113647e-11 miRNAWalker2_validate -0.272513561304296 3.70007401234902e-09 NA NA NA hsa-miR-148b-5p DUSP8 2.18024067300781 2.84770452413262e-14 -2.17002902781112 4.33786956113647e-11 mirMAP -0.321573633059071 2.41429931128124e-08 NA NA NA hsa-miR-17-5p DUSP8 3.2710598467455 9.93128340539455e-27 -2.17002902781112 4.33786956113647e-11 MirTarget;TargetScan;miRNATAP -0.27451324921957 2.82970370630617e-08 NA NA NA hsa-miR-185-3p DUSP8 2.3922478518806 1.3373426768452e-14 -2.17002902781112 4.33786956113647e-11 MirTarget -0.292910129532831 5.0454750028453e-09 NA NA NA hsa-miR-186-5p DUSP8 1.47445398888668 3.0781726595413e-15 -2.17002902781112 4.33786956113647e-11 miRNAWalker2_validate -0.47457346326056 1.66508483838079e-08 NA NA NA hsa-miR-18a-3p DUSP8 2.14813400940323 2.23460809936028e-06 -2.17002902781112 4.33786956113647e-11 mirMAP -0.126829157867463 0.00471428312205408 NA NA NA hsa-miR-1976 DUSP8 2.06550563678192 7.81396978619772e-18 -2.17002902781112 4.33786956113647e-11 MirTarget -0.326734072195072 4.70200681563067e-07 NA NA NA hsa-miR-20a-5p DUSP8 3.15577933619191 4.19753346442454e-25 -2.17002902781112 4.33786956113647e-11 MirTarget;miRNATAP -0.276645167586975 2.72543238714428e-08 NA NA NA hsa-miR-20b-5p DUSP8 2.07706563022469 1.10107236083433e-05 -2.17002902781112 4.33786956113647e-11 MirTarget;miRNATAP -0.101059122492511 0.00304482634665555 NA NA NA hsa-miR-21-5p DUSP8 2.73773305747971 1.38864982139576e-43 -2.17002902781112 4.33786956113647e-11 miRNAWalker2_validate;MirTarget -0.321318969065561 1.51976619875534e-05 NA NA NA hsa-miR-24-3p DUSP8 0.99989036772428 1.35595013650376e-07 -2.17002902781112 4.33786956113647e-11 MirTarget;miRNATAP -0.221148441937274 0.00994819570506222 NA NA NA hsa-miR-30b-3p DUSP8 0.834142820354026 0.000972582820878813 -2.17002902781112 4.33786956113647e-11 MirTarget -0.21317919003302 0.000983331948507059 NA NA NA hsa-miR-30d-3p DUSP8 0.977747550180601 4.3048212205381e-05 -2.17002902781112 4.33786956113647e-11 MirTarget;miRNATAP -0.226056193621441 0.000890035252235895 NA NA NA hsa-miR-30e-3p DUSP8 -0.215663037684509 0.235375122783546 -2.17002902781112 4.33786956113647e-11 MirTarget -0.305591397580463 0.000770298751661023 NA NA NA hsa-miR-320a DUSP8 0.438165828017084 0.0390159073347133 -2.17002902781112 4.33786956113647e-11 miRNAWalker2_validate -0.244274271447045 0.00158500441625888 NA NA NA hsa-miR-335-5p DUSP8 1.77247705492746 2.22457658872091e-06 -2.17002902781112 4.33786956113647e-11 mirMAP -0.129789115077203 0.00254000026263886 NA NA NA hsa-miR-342-5p DUSP8 1.74634624752902 3.89286511372155e-11 -2.17002902781112 4.33786956113647e-11 mirMAP -0.168492465736919 0.00540199842850723 NA NA NA hsa-miR-34a-5p DUSP8 1.9016323452565 1.43092834643601e-14 -2.17002902781112 4.33786956113647e-11 MirTarget -0.349194381507623 3.49403240680451e-08 NA NA NA hsa-miR-378c DUSP8 -0.14996196896414 0.564266703940495 -2.17002902781112 4.33786956113647e-11 miRNATAP -0.242606626135413 0.000111823398917625 NA NA NA hsa-miR-423-5p DUSP8 0.963563145758616 9.86109015204915e-07 -2.17002902781112 4.33786956113647e-11 MirTarget -0.478276472677194 4.2345752708924e-09 NA NA NA hsa-miR-429 DUSP8 4.48815175680773 2.44117492218206e-17 -2.17002902781112 4.33786956113647e-11 miRanda;miRNATAP -0.161716908637393 2.77220738078371e-08 NA NA NA hsa-miR-450b-5p DUSP8 1.69244418548325 1.68064054148881e-10 -2.17002902781112 4.33786956113647e-11 miRNATAP -0.218059299197764 0.000295309030822977 NA NA NA hsa-miR-452-3p DUSP8 2.42521958420768 4.08754552781156e-07 -2.17002902781112 4.33786956113647e-11 mirMAP -0.128321323815167 0.000132124936537621 NA NA NA hsa-miR-505-5p DUSP8 1.89243395287645 9.82003586561819e-12 -2.17002902781112 4.33786956113647e-11 mirMAP -0.337194731995205 2.43260399514129e-09 NA NA NA hsa-miR-582-3p DUSP8 0.00876844181512659 0.977126166214707 -2.17002902781112 4.33786956113647e-11 mirMAP -0.229644601375194 1.56956425648502e-05 NA NA NA hsa-miR-590-5p DUSP8 3.18300989862077 2.06813568597893e-26 -2.17002902781112 4.33786956113647e-11 MirTarget;PITA;miRanda;miRNATAP -0.330218223931402 1.60046750377914e-10 NA NA NA hsa-miR-625-5p DUSP8 1.42540152147292 1.95797147911206e-06 -2.17002902781112 4.33786956113647e-11 MirTarget -0.308500913889848 1.37839469332864e-07 NA NA NA hsa-miR-664a-5p DUSP8 0.505019913598436 0.032933350691651 -2.17002902781112 4.33786956113647e-11 mirMAP -0.280803085718235 4.87249246487942e-05 NA NA NA hsa-miR-671-5p DUSP8 2.97733652243246 1.21148452344738e-23 -2.17002902781112 4.33786956113647e-11 mirMAP -0.394420854600146 1.70722993347988e-13 NA NA NA hsa-miR-93-5p DUSP8 3.03961860136032 1.11672209617395e-24 -2.17002902781112 4.33786956113647e-11 miRNAWalker2_validate;MirTarget;miRNATAP -0.305490185597748 2.31067249400746e-09 NA NA NA hsa-miR-125a-5p EGFR 0.599529391575274 0.0102300147180307 -0.229170429190265 0.593897211976523 mirMAP -0.455142512240812 2.58435389092739e-07 19881956;27094723;24484870 We report that EGFR signaling leads to transcriptional repression of the miRNA miR-125a through the ETS family transcription factor PEA3;Suppression of microRNA 125a 5p upregulates the TAZ EGFR signaling pathway and promotes retinoblastoma proliferation; Moreover the overexpression of miR-125a-5p led to a decrease in TAZ expression and downstream EGFR signaling pathway activation both in vitro and vivo; Finally TAZ overexpression in retinoblastoma cells overexpressing miR-125a-5p restored retinoblastoma cell proliferation and EGFR pathway activation; Taken together our data demonstrated that miR-125a-5p functions as an important tumor suppressor that suppresses the EGFR pathway by targeting TAZ to inhibit tumor progression in retinoblastoma;miR 125a regulates cell cycle proliferation and apoptosis by targeting the ErbB pathway in acute myeloid leukemia; Profiling revealed the ErbB pathway as significantly decreased with ectopic miR-125a; Either ectopic expression of miR-125a or inhibition of ErbB via Mubritinib resulted in inhibition of cell cycle proliferation and progression with enhanced apoptosis revealing ErbB inhibitors as potential novel therapeutic agents for treating miR-125a-low AML ;progression;progression ovarian cancer;retinoblastoma;acute myeloid leukemia hsa-miR-140-5p EGFR 0.844753502512594 3.73722278438606e-05 -0.229170429190265 0.593897211976523 miRanda -0.290336016621899 0.00422174515988415 NA NA NA hsa-miR-148b-5p EGFR 2.18024067300781 2.84770452413262e-14 -0.229170429190265 0.593897211976523 mirMAP -0.287604854162764 0.000103760310070035 NA NA NA hsa-miR-186-5p EGFR 1.47445398888668 3.0781726595413e-15 -0.229170429190265 0.593897211976523 mirMAP -0.330064150409367 0.0023537398913317 NA NA NA hsa-miR-200a-3p EGFR 4.59434485520731 6.38952518573476e-18 -0.229170429190265 0.593897211976523 MirTarget -0.167369688006813 6.24721098372953e-06 19671845;26184032 Protein expression and signaling pathway modulation as well as intracellular distribution of EGFR and ERRFI-1 were validated through Western blot analysis and confocal microscopy whereas ERRFI-1 direct target of miR-200 members was validated by using the wild-type and mutant 3'-untranslated region/ERRFI-1/luciferse reporters; We identified a tight association between the expression of miRNAs of the miR-200 family epithelial phenotype and sensitivity to EGFR inhibitors-induced growth inhibition in bladder carcinoma cell lines; The changes in EGFR sensitivity by silencing or forced expression of ERRFI-1 or by miR-200 expression have also been validated in additional cell lines UMUC5 and T24; Members of the miR-200 family appear to control the EMT process and sensitivity to EGFR therapy in bladder cancer cells and the expression of miR-200 is sufficient to restore EGFR dependency at least in some of the mesenchymal bladder cancer cells;MicroRNA 200a Targets EGFR and c Met to Inhibit Migration Invasion and Gefitinib Resistance in Non Small Cell Lung Cancer; In this study we found that miR-200a is downregulated in NSCLC cells where it directly targets the 3'-UTR of both EGFR and c-Met mRNA; Overexpression of miR-200a in NSCLC cells significantly downregulates both EGFR and c-Met levels and severely inhibits cell migration and invasion ;drug resistance;cell migration bladder cancer;lung squamous cell cancer hsa-miR-29b-2-5p EGFR 0.910668640983475 0.00666655585493488 -0.229170429190265 0.593897211976523 mirMAP -0.416042511145117 5.70054998722675e-12 NA NA NA hsa-miR-30d-3p EGFR 0.977747550180601 4.3048212205381e-05 -0.229170429190265 0.593897211976523 mirMAP -0.297777237144485 0.000583685262316395 NA NA NA hsa-miR-362-5p EGFR 1.59303749908759 9.582675908797e-08 -0.229170429190265 0.593897211976523 mirMAP -0.241167685764662 0.00042775566379085 NA NA NA hsa-miR-374a-3p EGFR 0.533309330504947 0.00192918429705142 -0.229170429190265 0.593897211976523 mirMAP -0.472580799180365 0.000102592756227524 NA NA NA hsa-miR-374b-3p EGFR 0.930487774873495 2.74420094310516e-05 -0.229170429190265 0.593897211976523 mirMAP -0.31457186042627 0.000782176493255895 NA NA NA hsa-miR-3913-5p EGFR 2.44353493655328 8.95279496632448e-15 -0.229170429190265 0.593897211976523 mirMAP -0.259753924250973 7.19865795250564e-05 NA NA NA hsa-miR-7-1-3p EGFR 1.84950311431067 1.25300363397654e-13 -0.229170429190265 0.593897211976523 mirMAP -0.211992850385644 0.00900776269242333 NA NA NA hsa-miR-145-5p ELK4 -1.55259331973517 9.97889123247165e-07 -0.0594945014335 0.719948449635534 miRNATAP -0.103136119229449 3.14804749977247e-05 NA NA NA hsa-miR-195-3p ELK4 -0.658653229922836 0.0142127125129199 -0.0594945014335 0.719948449635534 mirMAP -0.108935047545339 0.000317524811176623 NA NA NA hsa-miR-29a-5p ELK4 1.46749674755271 3.34605004270294e-07 -0.0594945014335 0.719948449635534 mirMAP -0.132409557646135 4.49696024063371e-06 NA NA NA hsa-miR-30a-5p ELK4 -0.878357906436456 0.000509952992366057 -0.0594945014335 0.719948449635534 mirMAP -0.106353445793397 0.000748835466966222 NA NA NA hsa-miR-338-3p ELK4 0.453166438193782 0.144583389707558 -0.0594945014335 0.719948449635534 MirTarget;miRanda -0.148480999752756 5.0215513293591e-09 NA NA NA hsa-miR-342-3p ELK4 1.49115144672245 1.43879249744621e-07 -0.0594945014335 0.719948449635534 mirMAP -0.107290678418464 0.000111060467713661 NA NA NA hsa-miR-365a-3p ELK4 -0.0388985816963467 0.859114494267351 -0.0594945014335 0.719948449635534 mirMAP -0.101670194661552 0.00578592696327382 NA NA NA hsa-let-7a-5p FAS 0.618599506841644 2.76973453058748e-05 -0.893121037137088 0.00675655818216232 TargetScan -0.294996828851615 0.0073114418152214 NA NA NA hsa-miR-106a-5p FAS 2.48882002962836 1.99757727374521e-12 -0.893121037137088 0.00675655818216232 miRNAWalker2_validate;miRTarBase -0.286433262215431 2.93487884151059e-11 22431000;27142596 miR 106a is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS; Bioinformatic analysis combining with validation experiments identified FAS as a direct target of miR-106a; Moreover a significant inverse correlation was found between miR-106a and FAS expression not only in gastric cancer cell lines but also in gastric cancer specimens; Taken together these findings suggest that ectopicly overexpressed miR-106a may play an oncogenic role in gastric carcinogenesis and impair extrinsic apoptotic pathway through targeting FAS;Functional experiment ascertained that miR-106a interacted with FAS and mediated caspase3 pathway tumorigenesis; gastric cancer;gastric cancer hsa-miR-23b-3p FAS -0.251132426825047 0.150200321210792 -0.893121037137088 0.00675655818216232 miRNATAP -0.391116610184141 2.37246599324584e-05 24356489 Moreover over-expression of Fas rescued the pro-proliferation effect of miR-23 indicating Fas is a direct mediator of miR-23 functions; Furthermore contrast to miR-23a/b which was up regulated the Fas expression level was down-regulated and inversely correlated with miR-23 in split radiation induced lymphoma tissue samples; Finally our data also indicates that miR-23a could repress Fas much more potent than miR-23b and the additional region besides conserved seed pairing enables miR-23a's higher regulation lymphoma hsa-miR-361-5p FAS 0.971859117235239 5.30236555707088e-09 -0.893121037137088 0.00675655818216232 miRanda -0.765596610913641 1.34005865686507e-16 NA NA NA hsa-miR-491-5p FAS 0.615770352820862 0.0418295628761654 -0.893121037137088 0.00675655818216232 miRanda -0.202143347610942 0.000355416125267629 NA NA NA hsa-miR-590-5p FAS 3.18300989862077 2.06813568597893e-26 -0.893121037137088 0.00675655818216232 miRanda -0.26445516527792 2.22188286955534e-07 NA NA NA hsa-miR-98-5p FAS 1.11154309866014 1.24143909012085e-08 -0.893121037137088 0.00675655818216232 miRNAWalker2_validate -0.770550954607501 1.78193866759893e-23 NA NA NA hsa-let-7e-5p FASLG 0.860104282510173 6.04758298373779e-05 -0.196180452389551 0.711804379159628 miRNATAP -0.681095573446369 7.73237301751494e-09 NA NA NA hsa-miR-126-5p FGF1 0.895338176458417 2.33372756450713e-05 -0.0184880339301951 0.962515192576832 mirMAP -0.257052884478014 0.00418426830473386 NA NA NA hsa-miR-16-1-3p FGF1 2.56983217111073 3.02262181237943e-20 -0.0184880339301951 0.962515192576832 mirMAP -0.342294668806123 2.38586503825089e-07 NA NA NA hsa-miR-186-5p FGF1 1.47445398888668 3.0781726595413e-15 -0.0184880339301951 0.962515192576832 mirMAP -0.591026951034186 1.46187678760819e-09 NA NA NA hsa-miR-18a-5p FGF1 3.78535678765353 3.72446596213886e-26 -0.0184880339301951 0.962515192576832 MirTarget -0.264847474948657 3.88610261864251e-07 NA NA NA hsa-miR-205-5p FGF1 4.1389800495524 2.05488295686453e-12 -0.0184880339301951 0.962515192576832 mirMAP -0.157775223845845 3.59117960754949e-07 NA NA NA hsa-miR-26b-3p FGF1 2.18464160365372 2.11543189388328e-18 -0.0184880339301951 0.962515192576832 MirTarget -0.423230901828247 4.44177310978311e-09 NA NA NA hsa-miR-320a FGF1 0.438165828017084 0.0390159073347133 -0.0184880339301951 0.962515192576832 miRanda -0.541959251848306 9.85803319868347e-10 NA NA NA hsa-miR-320b FGF1 1.55692969039548 1.41071034251915e-08 -0.0184880339301951 0.962515192576832 miRanda -0.407239237545482 1.30349593223329e-09 NA NA NA hsa-miR-330-5p FGF1 1.15100069700871 4.85551805046014e-07 -0.0184880339301951 0.962515192576832 miRanda;miRNATAP -0.439171157719847 7.15817077978881e-08 NA NA NA hsa-miR-361-5p FGF1 0.971859117235239 5.30236555707088e-09 -0.0184880339301951 0.962515192576832 miRanda -0.85349859964158 1.1628109767779e-14 NA NA NA hsa-miR-3913-5p FGF1 2.44353493655328 8.95279496632448e-15 -0.0184880339301951 0.962515192576832 mirMAP -0.302608268342126 3.69363193887853e-07 NA NA NA hsa-miR-429 FGF1 4.48815175680773 2.44117492218206e-17 -0.0184880339301951 0.962515192576832 miRNATAP -0.267128349292686 9.69262295730924e-16 NA NA NA hsa-miR-484 FGF1 1.81844463411787 1.82951571230938e-15 -0.0184880339301951 0.962515192576832 MirTarget;PITA;miRNATAP -0.394116689453691 8.31708710335926e-07 NA NA NA hsa-miR-532-3p FGF1 1.96631878320218 4.53421954361695e-13 -0.0184880339301951 0.962515192576832 miRNATAP -0.440506181753794 4.21772989420151e-11 NA NA NA hsa-miR-550a-5p FGF1 2.11025227932763 6.94489556637146e-12 -0.0184880339301951 0.962515192576832 MirTarget -0.275012193152473 4.64050292544223e-06 NA NA NA hsa-miR-576-5p FGF1 2.20467023993664 3.4053475193793e-19 -0.0184880339301951 0.962515192576832 PITA;mirMAP -0.300128298067083 4.75057034180223e-05 NA NA NA hsa-miR-590-5p FGF1 3.18300989862077 2.06813568597893e-26 -0.0184880339301951 0.962515192576832 MirTarget;miRanda;miRNATAP -0.343013546630031 1.40984845888558e-08 NA NA NA hsa-miR-944 FGF1 2.91186649218281 1.31574753528144e-06 -0.0184880339301951 0.962515192576832 mirMAP -0.186547406811606 3.74734066850436e-09 NA NA NA hsa-miR-125b-5p FGF11 -1.16462950151259 0.000288900271798384 2.36629832780319 2.81026571264635e-10 mirMAP -0.245248887594589 1.73977327404226e-05 NA NA NA hsa-miR-195-5p FGF11 -1.44753678070504 8.70594292149271e-09 2.36629832780319 2.81026571264635e-10 mirMAP -0.349749547573844 1.22998816790053e-06 NA NA NA hsa-let-7f-1-3p FGF12 1.55054488387679 7.31326775537952e-11 -0.105634203581597 0.830798911418477 MirTarget -0.333111119559479 0.00101034935003356 NA NA NA hsa-miR-29a-5p FGF12 1.46749674755271 3.34605004270294e-07 -0.105634203581597 0.830798911418477 MirTarget -0.321702074213926 0.00020374538956914 NA NA NA hsa-miR-455-5p FGF12 2.2582442061694 1.43472128037398e-13 -0.105634203581597 0.830798911418477 miRanda -0.240066682606252 0.00156512301970859 NA NA NA hsa-let-7a-3p FGF13 1.42015538786275 7.03375209382654e-13 -2.79657067303141 1.56359356599715e-14 MirTarget;miRNATAP -0.476927207954888 9.11116431267741e-08 NA NA NA hsa-let-7b-3p FGF13 0.868207752019623 1.30460056774366e-05 -2.79657067303141 1.56359356599715e-14 MirTarget;miRNATAP -0.330311915944346 0.000291860606001036 NA NA NA hsa-let-7f-1-3p FGF13 1.55054488387679 7.31326775537952e-11 -2.79657067303141 1.56359356599715e-14 MirTarget -0.449044682518558 3.65397965548342e-09 NA NA NA hsa-let-7g-3p FGF13 3.26398061402445 3.96263126107645e-25 -2.79657067303141 1.56359356599715e-14 miRNATAP -0.407085198701305 7.16106489006225e-14 NA NA NA hsa-miR-141-3p FGF13 5.02396127982626 2.19224509139725e-24 -2.79657067303141 1.56359356599715e-14 TargetScan -0.302898746415501 8.87758287571865e-20 NA NA NA hsa-miR-200a-5p FGF13 3.86316681673704 1.81076942093171e-15 -2.79657067303141 1.56359356599715e-14 MirTarget;miRNATAP -0.21982450079845 5.72965300252089e-10 NA NA NA hsa-miR-200b-5p FGF13 2.54484902707822 1.59240467582976e-06 -2.79657067303141 1.56359356599715e-14 MirTarget -0.225797054463804 1.92722376445309e-09 NA NA NA hsa-miR-3065-3p FGF13 2.16221780121195 9.65525739884541e-09 -2.79657067303141 1.56359356599715e-14 MirTarget;miRNATAP -0.190085596758735 5.63840821082238e-05 NA NA NA hsa-miR-3065-5p FGF13 2.74629919868982 1.86846589298284e-08 -2.79657067303141 1.56359356599715e-14 MirTarget;mirMAP;miRNATAP -0.209349645962154 2.57152126823624e-06 NA NA NA hsa-miR-31-3p FGF13 2.70807981248858 8.84479434501203e-05 -2.79657067303141 1.56359356599715e-14 miRNATAP -0.185125316927806 4.97759365271198e-11 NA NA NA hsa-miR-34c-5p FGF13 2.07190852984647 7.35776320806257e-08 -2.79657067303141 1.56359356599715e-14 miRanda -0.174558299761964 0.00042811021121569 NA NA NA hsa-miR-421 FGF13 1.17791565395543 6.78526676976629e-06 -2.79657067303141 1.56359356599715e-14 MirTarget;PITA;miRanda;miRNATAP -0.272548837534654 7.748381820303e-05 NA NA NA hsa-miR-429 FGF13 4.48815175680773 2.44117492218206e-17 -2.79657067303141 1.56359356599715e-14 miRNATAP -0.206395285212018 1.65735860319463e-10 NA NA NA hsa-miR-455-5p FGF13 2.2582442061694 1.43472128037398e-13 -2.79657067303141 1.56359356599715e-14 PITA;miRanda -0.308345140645582 7.0083826972615e-08 NA NA NA hsa-miR-511-5p FGF13 1.04499312543772 0.00234126154508174 -2.79657067303141 1.56359356599715e-14 MirTarget -0.14578918114989 0.00585401970078833 NA NA NA hsa-miR-590-3p FGF13 2.59289455139753 1.03200520972022e-21 -2.79657067303141 1.56359356599715e-14 miRanda -0.50056116303806 4.23454497035437e-15 NA NA NA hsa-miR-7-1-3p FGF13 1.84950311431067 1.25300363397654e-13 -2.79657067303141 1.56359356599715e-14 MirTarget;mirMAP -0.404511369528413 7.64132929406128e-09 NA NA NA hsa-miR-421 FGF14 1.17791565395543 6.78526676976629e-06 -1.46844557178328 0.00268591599153301 miRanda -0.637683195269129 4.6282816865839e-13 NA NA NA hsa-miR-590-3p FGF14 2.59289455139753 1.03200520972022e-21 -1.46844557178328 0.00268591599153301 miRanda -0.549518148621001 6.75806376569127e-11 NA NA NA hsa-miR-96-5p FGF14 4.89433085814374 1.92000659886961e-31 -1.46844557178328 0.00268591599153301 TargetScan -0.32531579054151 7.90142217061031e-10 NA NA NA hsa-miR-103a-3p FGF18 1.44083190496858 1.53799939616416e-13 -1.42483047022124 0.00103718898766565 miRNATAP -0.356068506298048 0.000774817673325315 NA NA NA hsa-miR-107 FGF18 1.30977326593435 1.30372468603965e-11 -1.42483047022124 0.00103718898766565 miRNATAP -0.425066640569775 7.22213089698089e-05 NA NA NA hsa-miR-15a-5p FGF18 2.34669284378787 1.69544424500258e-23 -1.42483047022124 0.00103718898766565 miRNATAP -0.464224982406698 3.74903170207201e-08 NA NA NA hsa-miR-15b-5p FGF18 1.57112623124278 9.14247846750597e-13 -1.42483047022124 0.00103718898766565 miRNATAP -0.618422336678395 1.80376185685917e-11 NA NA NA hsa-miR-16-5p FGF18 1.75824877145857 1.68592440033108e-16 -1.42483047022124 0.00103718898766565 miRNATAP -0.716652518248879 1.53715937075798e-14 NA NA NA hsa-miR-200b-3p FGF18 3.78235093249346 3.18343003239465e-14 -1.42483047022124 0.00103718898766565 TargetScan -0.155406687950871 0.000140098893382056 NA NA NA hsa-miR-200c-3p FGF18 3.50132673580082 2.42716349086937e-15 -1.42483047022124 0.00103718898766565 miRNATAP -0.257330688592158 1.44969551897125e-08 NA NA NA hsa-miR-21-5p FGF18 2.73773305747971 1.38864982139576e-43 -1.42483047022124 0.00103718898766565 miRNATAP -0.441803837579941 4.23160631739167e-06 NA NA NA hsa-miR-330-5p FGF18 1.15100069700871 4.85551805046014e-07 -1.42483047022124 0.00103718898766565 PITA;miRanda;miRNATAP -0.343613128640874 0.000170129552940752 NA NA NA hsa-miR-424-5p FGF18 1.61930224569578 1.89642549274994e-10 -1.42483047022124 0.00103718898766565 miRNATAP -0.26186546069637 0.00131478568853092 NA NA NA hsa-miR-429 FGF18 4.48815175680773 2.44117492218206e-17 -1.42483047022124 0.00103718898766565 miRNATAP -0.135424427434448 0.000379262258909638 NA NA NA hsa-miR-505-3p FGF18 1.45322244209148 8.86597629645867e-10 -1.42483047022124 0.00103718898766565 miRNATAP -0.493018097870616 1.21245467333208e-08 NA NA NA hsa-miR-590-5p FGF18 3.18300989862077 2.06813568597893e-26 -1.42483047022124 0.00103718898766565 miRanda;miRNATAP -0.376932190079452 2.06770613305322e-08 NA NA NA hsa-let-7a-3p FGF2 1.42015538786275 7.03375209382654e-13 -3.45935256477983 3.20406041037898e-17 mirMAP -0.57039623316549 1.64408016446008e-08 NA NA NA hsa-let-7b-3p FGF2 0.868207752019623 1.30460056774366e-05 -3.45935256477983 3.20406041037898e-17 mirMAP -0.530485029047925 2.33230657638534e-07 NA NA NA hsa-let-7f-1-3p FGF2 1.55054488387679 7.31326775537952e-11 -3.45935256477983 3.20406041037898e-17 mirMAP -0.403619323347166 3.50383349222099e-06 NA NA NA hsa-miR-103a-3p FGF2 1.44083190496858 1.53799939616416e-13 -3.45935256477983 3.20406041037898e-17 miRNAWalker2_validate;MirTarget;miRNATAP -0.951198901738798 5.80167380051094e-22 NA NA NA hsa-miR-107 FGF2 1.30977326593435 1.30372468603965e-11 -3.45935256477983 3.20406041037898e-17 MirTarget;PITA;miRanda;miRNATAP -0.746537045946991 3.12339725479843e-13 NA NA NA hsa-miR-10b-3p FGF2 0.77597971642517 0.00264877454133753 -3.45935256477983 3.20406041037898e-17 mirMAP -0.38765486044307 1.00531657460278e-06 NA NA NA hsa-miR-1226-3p FGF2 1.38118928579963 0.000205503474787488 -3.45935256477983 3.20406041037898e-17 MirTarget -0.406312709645584 4.86442323802081e-11 NA NA NA hsa-miR-144-3p FGF2 0.658119849508907 0.146943823997989 -3.45935256477983 3.20406041037898e-17 MirTarget -0.150660886736508 0.00130127640996876 NA NA NA hsa-miR-148a-5p FGF2 1.16173838132242 0.000148929299881612 -3.45935256477983 3.20406041037898e-17 mirMAP -0.175801486236704 0.00879070967495281 NA NA NA hsa-miR-15a-5p FGF2 2.34669284378787 1.69544424500258e-23 -3.45935256477983 3.20406041037898e-17 MirTarget;miRNATAP -0.8665754259228 1.51865052824555e-28 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-3p FGF2 2.33847028227712 4.29662877950836e-19 -3.45935256477983 3.20406041037898e-17 mirMAP -0.698237395560323 2.98047943363042e-22 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-5p FGF2 1.57112623124278 9.14247846750597e-13 -3.45935256477983 3.20406041037898e-17 MirTarget;miRNATAP -0.772339849603923 2.2379572945642e-18 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-1-3p FGF2 2.56983217111073 3.02262181237943e-20 -3.45935256477983 3.20406041037898e-17 mirMAP -0.706717215195114 8.84760087286705e-25 NA NA NA hsa-miR-16-2-3p FGF2 2.31623086727196 4.29838149388188e-20 -3.45935256477983 3.20406041037898e-17 mirMAP -0.642959805706348 1.63529117433717e-17 NA NA NA hsa-miR-16-5p FGF2 1.75824877145857 1.68592440033108e-16 -3.45935256477983 3.20406041037898e-17 miRNAWalker2_validate;MirTarget;miRNATAP -0.791482784689716 1.7414135213028e-18 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-181a-5p FGF2 2.29556023480783 1.8138457900616e-21 -3.45935256477983 3.20406041037898e-17 mirMAP -0.525450431942733 5.3421915793276e-11 NA NA NA hsa-miR-181b-5p FGF2 2.49307679431293 3.92829250217627e-20 -3.45935256477983 3.20406041037898e-17 mirMAP -0.487813576366985 7.1537699850524e-12 NA NA NA hsa-miR-181c-5p FGF2 1.58587920618301 1.57506918816933e-10 -3.45935256477983 3.20406041037898e-17 mirMAP -0.402853563332211 6.66481994248428e-07 NA NA NA hsa-miR-186-5p FGF2 1.47445398888668 3.0781726595413e-15 -3.45935256477983 3.20406041037898e-17 miRNAWalker2_validate;mirMAP -0.865396245604199 9.71640315277788e-17 NA NA NA hsa-miR-192-5p FGF2 2.69002528723195 1.22990188194432e-16 -3.45935256477983 3.20406041037898e-17 miRNAWalker2_validate -0.55945113419736 8.27439417486679e-22 NA NA NA hsa-miR-19b-1-5p FGF2 2.57951428759379 4.31576118703427e-20 -3.45935256477983 3.20406041037898e-17 mirMAP -0.684742945615863 1.47856020889472e-23 NA NA NA hsa-miR-200b-3p FGF2 3.78235093249346 3.18343003239465e-14 -3.45935256477983 3.20406041037898e-17 mirMAP -0.442848247331966 6.36624370256829e-33 NA NA NA hsa-miR-200c-3p FGF2 3.50132673580082 2.42716349086937e-15 -3.45935256477983 3.20406041037898e-17 mirMAP -0.581898672989235 1.2281612826909e-47 NA NA NA hsa-miR-20a-3p FGF2 2.92621109947706 2.49504904635375e-17 -3.45935256477983 3.20406041037898e-17 mirMAP -0.521338868643764 2.37178789361296e-20 NA NA NA hsa-miR-21-3p FGF2 2.19296355304364 4.63665722759779e-15 -3.45935256477983 3.20406041037898e-17 mirMAP -0.389762818312192 3.3064358783093e-08 NA NA NA hsa-miR-21-5p FGF2 2.73773305747971 1.38864982139576e-43 -3.45935256477983 3.20406041037898e-17 mirMAP -0.590129232102637 2.05709217680526e-10 NA NA NA hsa-miR-215-5p FGF2 2.30755467422978 2.38476032118039e-06 -3.45935256477983 3.20406041037898e-17 miRNAWalker2_validate -0.234704807386955 3.03139328926694e-08 NA NA NA hsa-miR-32-5p FGF2 2.34056473219422 6.24134585974322e-20 -3.45935256477983 3.20406041037898e-17 miRNAWalker2_validate -0.528631961245202 2.37324737115731e-12 NA NA NA hsa-miR-330-3p FGF2 0.876747334239085 0.00073709016089703 -3.45935256477983 3.20406041037898e-17 mirMAP -0.408493425882602 1.96553818290449e-07 NA NA NA hsa-miR-335-3p FGF2 3.08791651139852 5.31309869723517e-12 -3.45935256477983 3.20406041037898e-17 mirMAP -0.283343671500426 1.16812423839489e-10 NA NA NA hsa-miR-335-5p FGF2 1.77247705492746 2.22457658872091e-06 -3.45935256477983 3.20406041037898e-17 miRNATAP -0.204481115239778 0.000164239409089154 NA NA NA hsa-miR-361-5p FGF2 0.971859117235239 5.30236555707088e-09 -3.45935256477983 3.20406041037898e-17 mirMAP -1.05676685455326 5.59900406122503e-19 NA NA NA hsa-miR-429 FGF2 4.48815175680773 2.44117492218206e-17 -3.45935256477983 3.20406041037898e-17 mirMAP -0.410445998774638 1.8378122494787e-32 NA NA NA hsa-miR-450b-5p FGF2 1.69244418548325 1.68064054148881e-10 -3.45935256477983 3.20406041037898e-17 mirMAP -0.300742012229277 7.83074250991869e-05 NA NA NA hsa-miR-452-5p FGF2 1.37180058737183 0.00171494843537772 -3.45935256477983 3.20406041037898e-17 mirMAP -0.212195200331281 5.19684741170909e-06 NA NA NA hsa-miR-503-5p FGF2 3.66513190181895 6.60300917645278e-21 -3.45935256477983 3.20406041037898e-17 miRNAWalker2_validate -0.407288478531313 2.50922381458507e-15 NA NA NA hsa-miR-589-3p FGF2 2.51971841868825 2.39125940264107e-11 -3.45935256477983 3.20406041037898e-17 mirMAP -0.381356804586547 1.66276905891645e-10 NA NA NA hsa-miR-590-3p FGF2 2.59289455139753 1.03200520972022e-21 -3.45935256477983 3.20406041037898e-17 miRanda;mirMAP -0.518258185319804 1.08846109843951e-12 NA NA NA hsa-miR-590-5p FGF2 3.18300989862077 2.06813568597893e-26 -3.45935256477983 3.20406041037898e-17 miRanda;mirMAP -0.632565141691195 1.29154238410301e-23 NA NA NA hsa-miR-664a-3p FGF2 0.634721925861133 0.00520070178640421 -3.45935256477983 3.20406041037898e-17 mirMAP -0.355728775133404 9.0166815375644e-05 NA NA NA hsa-miR-92a-3p FGF2 2.06460102658973 1.44784291084757e-19 -3.45935256477983 3.20406041037898e-17 miRNAWalker2_validate -0.899992154982756 2.08015519442665e-28 NA NA NA hsa-miR-93-3p FGF2 2.85383869771942 5.64481766902125e-23 -3.45935256477983 3.20406041037898e-17 mirMAP -0.750363342236745 4.93373884627099e-33 NA NA NA hsa-miR-944 FGF2 2.91186649218281 1.31574753528144e-06 -3.45935256477983 3.20406041037898e-17 MirTarget -0.33196588658737 1.10637179732889e-23 NA NA NA hsa-let-7a-5p FGF5 0.618599506841644 2.76973453058748e-05 0.295109479545415 0.629573395554456 TargetScan -0.91814617286066 5.32530775182813e-06 NA NA NA hsa-miR-16-1-3p FGF5 2.56983217111073 3.02262181237943e-20 0.295109479545415 0.629573395554456 mirMAP -0.338734686460559 0.00113538866111799 NA NA NA hsa-miR-30b-5p FGF5 0.800822374912712 0.000133601914525413 0.295109479545415 0.629573395554456 mirMAP -0.600640883736003 1.90348300406499e-05 NA NA NA hsa-miR-30c-5p FGF5 0.778774633108 0.000285599212429136 0.295109479545415 0.629573395554456 mirMAP -0.92040630911618 9.17796831458907e-12 NA NA NA hsa-miR-30d-5p FGF5 0.675423997639582 0.00270618816039773 0.295109479545415 0.629573395554456 mirMAP -1.13295918526447 3.0017545458782e-19 NA NA NA hsa-miR-30e-5p FGF5 1.23904909539663 1.35561917122157e-09 0.295109479545415 0.629573395554456 mirMAP -1.15649538412346 5.357826498539e-17 NA NA NA hsa-miR-33a-3p FGF5 1.72765312072219 1.51784443453521e-07 0.295109479545415 0.629573395554456 mirMAP -0.539068199759696 2.08072885141182e-08 NA NA NA hsa-miR-3607-3p FGF5 2.68532138541128 5.66716351955047e-14 0.295109479545415 0.629573395554456 miRNATAP -0.234633949263568 0.00441910591787781 NA NA NA hsa-miR-361-5p FGF5 0.971859117235239 5.30236555707088e-09 0.295109479545415 0.629573395554456 miRanda -0.526008521902236 0.00299705315333712 NA NA NA hsa-miR-3913-5p FGF5 2.44353493655328 8.95279496632448e-15 0.295109479545415 0.629573395554456 mirMAP -0.454773813139765 9.34182245565845e-07 NA NA NA hsa-miR-425-5p FGF5 3.07071373939774 4.02947460586085e-25 0.295109479545415 0.629573395554456 mirMAP -0.36043366586368 0.000119548832083508 NA NA NA hsa-miR-582-5p FGF5 0.609226359812689 0.032988717891497 0.295109479545415 0.629573395554456 mirMAP -0.50108445051561 1.06699099148979e-06 NA NA NA hsa-let-7a-3p FGF7 1.42015538786275 7.03375209382654e-13 -3.51313263207438 7.95527572408387e-12 MirTarget;miRNATAP -0.868051763208098 2.15246923266363e-12 NA NA NA hsa-let-7b-3p FGF7 0.868207752019623 1.30460056774366e-05 -3.51313263207438 7.95527572408387e-12 MirTarget;miRNATAP -0.686098645885029 5.95476501085241e-08 NA NA NA hsa-let-7f-1-3p FGF7 1.55054488387679 7.31326775537952e-11 -3.51313263207438 7.95527572408387e-12 MirTarget -0.422294734283416 9.10473994373525e-05 NA NA NA hsa-miR-107 FGF7 1.30977326593435 1.30372468603965e-11 -3.51313263207438 7.95527572408387e-12 PITA;miRanda;miRNATAP -1.33350776374428 6.88980795931608e-28 NA NA NA hsa-miR-125a-3p FGF7 1.24490295132072 5.26925231010328e-06 -3.51313263207438 7.95527572408387e-12 miRanda -0.36428154542973 7.97695913996567e-05 NA NA NA hsa-miR-126-5p FGF7 0.895338176458417 2.33372756450713e-05 -3.51313263207438 7.95527572408387e-12 miRNATAP -0.50607130713236 2.39566802274335e-05 NA NA NA hsa-miR-15a-5p FGF7 2.34669284378787 1.69544424500258e-23 -3.51313263207438 7.95527572408387e-12 miRTarBase;miRNATAP -1.05153766439707 1.95358882887929e-27 NA NA NA hsa-miR-15b-5p FGF7 1.57112623124278 9.14247846750597e-13 -3.51313263207438 7.95527572408387e-12 miRNATAP -1.2675059921588 1.34716750524093e-33 NA NA NA hsa-miR-16-1-3p FGF7 2.56983217111073 3.02262181237943e-20 -3.51313263207438 7.95527572408387e-12 mirMAP -0.962633495741247 1.30046319779539e-30 NA NA NA hsa-miR-16-2-3p FGF7 2.31623086727196 4.29838149388188e-20 -3.51313263207438 7.95527572408387e-12 mirMAP -1.03435039613724 1.94620052074685e-30 NA NA NA hsa-miR-16-5p FGF7 1.75824877145857 1.68592440033108e-16 -3.51313263207438 7.95527572408387e-12 miRNATAP -1.28612319073303 4.51638848249496e-33 NA NA NA hsa-miR-18a-3p FGF7 2.14813400940323 2.23460809936028e-06 -3.51313263207438 7.95527572408387e-12 MirTarget -0.556498884313971 2.26092390202209e-16 NA NA NA hsa-miR-20a-5p FGF7 3.15577933619191 4.19753346442454e-25 -3.51313263207438 7.95527572408387e-12 miRNAWalker2_validate -0.868623781957236 1.39584172420003e-32 NA NA NA hsa-miR-26b-5p FGF7 0.885393662798425 3.2116297961629e-06 -3.51313263207438 7.95527572408387e-12 mirMAP -0.847719846249514 1.19855193491048e-10 NA NA NA hsa-miR-27a-3p FGF7 1.66542180327138 4.93775737894805e-13 -3.51313263207438 7.95527572408387e-12 MirTarget -0.496262584130317 3.80940705649825e-06 NA NA NA hsa-miR-30d-3p FGF7 0.977747550180601 4.3048212205381e-05 -3.51313263207438 7.95527572408387e-12 miRNATAP -0.98464350645187 2.65309361395091e-22 NA NA NA hsa-miR-31-5p FGF7 3.59165123035072 2.27423212057482e-07 -3.51313263207438 7.95527572408387e-12 MirTarget -0.242511081652209 1.15595308501103e-10 NA NA NA hsa-miR-320a FGF7 0.438165828017084 0.0390159073347133 -3.51313263207438 7.95527572408387e-12 miRanda -0.863658740998593 2.38979957240199e-13 NA NA NA hsa-miR-320b FGF7 1.55692969039548 1.41071034251915e-08 -3.51313263207438 7.95527572408387e-12 miRanda -0.8900673002199 8.8221661934298e-25 NA NA NA hsa-miR-33a-3p FGF7 1.72765312072219 1.51784443453521e-07 -3.51313263207438 7.95527572408387e-12 mirMAP -0.869749595956586 2.33649296944708e-28 NA NA NA hsa-miR-3607-3p FGF7 2.68532138541128 5.66716351955047e-14 -3.51313263207438 7.95527572408387e-12 mirMAP -0.64929482323457 8.99724661665848e-22 NA NA NA hsa-miR-361-5p FGF7 0.971859117235239 5.30236555707088e-09 -3.51313263207438 7.95527572408387e-12 PITA;miRanda;miRNATAP -1.56289686557936 1.23555434322998e-27 NA NA NA hsa-miR-374a-3p FGF7 0.533309330504947 0.00192918429705142 -3.51313263207438 7.95527572408387e-12 miRNATAP -0.673095249598969 6.22712424951211e-06 NA NA NA hsa-miR-421 FGF7 1.17791565395543 6.78526676976629e-06 -3.51313263207438 7.95527572408387e-12 miRanda -0.61796765882037 8.36534413441402e-11 NA NA NA hsa-miR-429 FGF7 4.48815175680773 2.44117492218206e-17 -3.51313263207438 7.95527572408387e-12 miRNATAP -0.443581603298994 3.06942783866656e-24 NA NA NA hsa-miR-452-5p FGF7 1.37180058737183 0.00171494843537772 -3.51313263207438 7.95527572408387e-12 mirMAP -0.249611725832981 1.47380993562818e-05 NA NA NA hsa-miR-455-3p FGF7 3.06093594997644 3.54590649799868e-16 -3.51313263207438 7.95527572408387e-12 PITA;miRNATAP -0.607725997000264 1.53851303208614e-22 NA NA NA hsa-miR-484 FGF7 1.81844463411787 1.82951571230938e-15 -3.51313263207438 7.95527572408387e-12 PITA -0.960272098641967 1.85266514198687e-20 NA NA NA hsa-miR-486-5p FGF7 -0.194913133034028 0.607377798807705 -3.51313263207438 7.95527572408387e-12 MirTarget;miRanda -0.350475600632684 1.38246507581354e-07 NA NA NA hsa-miR-501-5p FGF7 1.93654809410041 1.3779381780759e-10 -3.51313263207438 7.95527572408387e-12 PITA;mirMAP -0.377449765945373 8.38821662648711e-06 NA NA NA hsa-miR-582-3p FGF7 0.00876844181512659 0.977126166214707 -3.51313263207438 7.95527572408387e-12 PITA;miRNATAP -0.444512234576302 7.58144669390707e-08 NA NA NA hsa-miR-590-3p FGF7 2.59289455139753 1.03200520972022e-21 -3.51313263207438 7.95527572408387e-12 PITA;miRanda;mirMAP;miRNATAP -0.837742801847946 1.56917534011074e-21 NA NA NA hsa-miR-590-5p FGF7 3.18300989862077 2.06813568597893e-26 -3.51313263207438 7.95527572408387e-12 PITA;miRanda -0.82452421363643 1.87090418897067e-26 NA NA NA hsa-miR-7-1-3p FGF7 1.84950311431067 1.25300363397654e-13 -3.51313263207438 7.95527572408387e-12 mirMAP -0.853688804833789 4.05730521370535e-19 NA NA NA hsa-miR-944 FGF7 2.91186649218281 1.31574753528144e-06 -3.51313263207438 7.95527572408387e-12 mirMAP -0.392489693630891 1.34607680998663e-21 NA NA NA hsa-miR-142-3p FGF9 2.75247908790621 1.45636065474764e-12 -4.26095125698269 8.03301928631002e-16 miRanda -0.304602080556944 3.74420488921244e-06 NA NA NA hsa-miR-142-5p FGF9 1.17581605694506 0.0018174701991234 -4.26095125698269 8.03301928631002e-16 mirMAP -0.238268156517486 0.000658901150979571 NA NA NA hsa-miR-15a-5p FGF9 2.34669284378787 1.69544424500258e-23 -4.26095125698269 8.03301928631002e-16 miRNATAP -0.613515930639976 6.81151068408031e-09 NA NA NA hsa-miR-15b-5p FGF9 1.57112623124278 9.14247846750597e-13 -4.26095125698269 8.03301928631002e-16 miRNATAP -0.802569271834457 3.63021724126861e-12 NA NA NA hsa-miR-16-2-3p FGF9 2.31623086727196 4.29838149388188e-20 -4.26095125698269 8.03301928631002e-16 mirMAP -0.800367524866385 2.04134354031929e-16 NA NA NA hsa-miR-16-5p FGF9 1.75824877145857 1.68592440033108e-16 -4.26095125698269 8.03301928631002e-16 miRNATAP -0.883505660298818 5.27035859785824e-14 NA NA NA hsa-miR-181a-5p FGF9 2.29556023480783 1.8138457900616e-21 -4.26095125698269 8.03301928631002e-16 mirMAP -0.489899182058424 2.6269594131992e-06 NA NA NA hsa-miR-181b-5p FGF9 2.49307679431293 3.92829250217627e-20 -4.26095125698269 8.03301928631002e-16 mirMAP -0.508260400727932 3.82554365417734e-08 NA NA NA hsa-miR-182-5p FGF9 3.53923166221814 5.07781258121574e-21 -4.26095125698269 8.03301928631002e-16 miRTarBase;miRNATAP -0.199763187583912 0.00291090860779188 NA NA NA hsa-miR-183-5p FGF9 4.19757025992371 4.79612296318304e-26 -4.26095125698269 8.03301928631002e-16 miRNATAP -0.247497021287039 7.27398434498139e-05 NA NA NA hsa-miR-186-5p FGF9 1.47445398888668 3.0781726595413e-15 -4.26095125698269 8.03301928631002e-16 mirMAP -0.699532502904695 3.5394259788128e-07 NA NA NA hsa-miR-205-5p FGF9 4.1389800495524 2.05488295686453e-12 -4.26095125698269 8.03301928631002e-16 miRNATAP -0.326036683952424 1.66736877723578e-14 NA NA NA hsa-miR-212-3p FGF9 0.357878936470387 0.232446214501331 -4.26095125698269 8.03301928631002e-16 mirMAP -0.242923523642108 0.00659695119245421 NA NA NA hsa-miR-26b-5p FGF9 0.885393662798425 3.2116297961629e-06 -4.26095125698269 8.03301928631002e-16 miRNAWalker2_validate -0.463461132249546 0.00089179354119325 NA NA NA hsa-miR-32-3p FGF9 2.02436999565685 5.94091197945307e-09 -4.26095125698269 8.03301928631002e-16 mirMAP -0.424513773785253 5.42028936260741e-07 NA NA NA hsa-miR-320b FGF9 1.55692969039548 1.41071034251915e-08 -4.26095125698269 8.03301928631002e-16 mirMAP;miRNATAP -0.355538591217071 0.000183486822496139 NA NA NA hsa-miR-330-5p FGF9 1.15100069700871 4.85551805046014e-07 -4.26095125698269 8.03301928631002e-16 miRanda;miRNATAP -0.423366003580199 0.000230055048357782 NA NA NA hsa-miR-3607-3p FGF9 2.68532138541128 5.66716351955047e-14 -4.26095125698269 8.03301928631002e-16 miRNATAP -0.24313494691515 0.000999639918173201 NA NA NA hsa-miR-424-5p FGF9 1.61930224569578 1.89642549274994e-10 -4.26095125698269 8.03301928631002e-16 miRNATAP -0.58737553539275 6.18032575679243e-09 NA NA NA hsa-miR-450b-5p FGF9 1.69244418548325 1.68064054148881e-10 -4.26095125698269 8.03301928631002e-16 mirMAP;miRNATAP -0.340701382488691 0.000517592246201871 NA NA NA hsa-miR-455-5p FGF9 2.2582442061694 1.43472128037398e-13 -4.26095125698269 8.03301928631002e-16 miRanda -0.514569349219032 5.600682082645e-10 NA NA NA hsa-miR-500a-5p FGF9 1.72110365584658 3.0807246212659e-10 -4.26095125698269 8.03301928631002e-16 miRNATAP -0.305215850049758 0.00136645365694185 NA NA NA hsa-miR-501-3p FGF9 1.83132758513743 1.10971547702065e-10 -4.26095125698269 8.03301928631002e-16 miRNATAP -0.275213501706133 0.00266614535053256 NA NA NA hsa-miR-502-3p FGF9 1.50560877085049 1.2647489756373e-11 -4.26095125698269 8.03301928631002e-16 miRNATAP -0.472515714777411 5.16045988653371e-05 NA NA NA hsa-miR-590-3p FGF9 2.59289455139753 1.03200520972022e-21 -4.26095125698269 8.03301928631002e-16 miRanda;mirMAP -0.634218650148273 1.44459862312323e-11 NA NA NA hsa-miR-590-5p FGF9 3.18300989862077 2.06813568597893e-26 -4.26095125698269 8.03301928631002e-16 miRanda -0.585459859087567 2.600352130665e-12 NA NA NA hsa-miR-744-3p FGF9 2.7517405670917 4.22040908411227e-14 -4.26095125698269 8.03301928631002e-16 miRNATAP -0.478257215030822 4.08425547781364e-12 NA NA NA hsa-miR-944 FGF9 2.91186649218281 1.31574753528144e-06 -4.26095125698269 8.03301928631002e-16 mirMAP -0.299847632396488 8.53539059567662e-12 NA NA NA hsa-miR-96-5p FGF9 4.89433085814374 1.92000659886961e-31 -4.26095125698269 8.03301928631002e-16 TargetScan;miRNATAP -0.27635466915326 3.67018504641498e-06 NA NA NA hsa-miR-106a-5p FGFR1 2.48882002962836 1.99757727374521e-12 -2.87837421637657 3.11921581471297e-13 mirMAP -0.384049482399962 3.23721514703937e-13 NA NA NA hsa-miR-106b-5p FGFR1 2.46782146831112 1.36171495805632e-23 -2.87837421637657 3.11921581471297e-13 mirMAP -0.786989656536899 1.34893666834924e-28 NA NA NA hsa-miR-10a-5p FGFR1 1.15016989191194 0.00372037233992369 -2.87837421637657 3.11921581471297e-13 miRNAWalker2_validate -0.337275460563786 2.76715914740678e-12 21738581 Predicted target mRNAs FGFR1 miR-10 and MLH1 miR-155 were found downregulated pancreatic cancer hsa-miR-135b-5p FGFR1 3.62510365056501 1.09148980810091e-10 -2.87837421637657 3.11921581471297e-13 mirMAP -0.256448226944969 3.75332453789719e-13 NA NA NA hsa-miR-15a-5p FGFR1 2.34669284378787 1.69544424500258e-23 -2.87837421637657 3.11921581471297e-13 miRNATAP -0.754714476564242 1.61012864706111e-23 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-5p FGFR1 1.57112623124278 9.14247846750597e-13 -2.87837421637657 3.11921581471297e-13 miRNATAP -0.775708333138364 1.99211850175655e-20 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-5p FGFR1 1.75824877145857 1.68592440033108e-16 -2.87837421637657 3.11921581471297e-13 miRTarBase;miRNATAP -0.872588788016778 5.80543636431341e-25 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-17-5p FGFR1 3.2710598467455 9.93128340539455e-27 -2.87837421637657 3.11921581471297e-13 mirMAP -0.561714096530076 1.45885352023962e-22 NA NA NA hsa-miR-181b-5p FGFR1 2.49307679431293 3.92829250217627e-20 -2.87837421637657 3.11921581471297e-13 miRNAWalker2_validate -0.302065593540415 1.18303842029487e-05 NA NA NA hsa-miR-200a-5p FGFR1 3.86316681673704 1.81076942093171e-15 -2.87837421637657 3.11921581471297e-13 mirMAP -0.445799640285698 2.0477017707227e-35 NA NA NA hsa-miR-200b-5p FGFR1 2.54484902707822 1.59240467582976e-06 -2.87837421637657 3.11921581471297e-13 mirMAP -0.423363595037777 9.00824115860094e-28 NA NA NA hsa-miR-20a-5p FGFR1 3.15577933619191 4.19753346442454e-25 -2.87837421637657 3.11921581471297e-13 mirMAP -0.555458710370069 9.61690870294644e-22 NA NA NA hsa-miR-20b-5p FGFR1 2.07706563022469 1.10107236083433e-05 -2.87837421637657 3.11921581471297e-13 mirMAP -0.209937819299542 2.53129403166548e-07 NA NA NA hsa-miR-301a-3p FGFR1 2.81024345929638 2.29784847962242e-17 -2.87837421637657 3.11921581471297e-13 mirMAP -0.457918632801525 5.01605114375097e-15 NA NA NA hsa-miR-3065-5p FGFR1 2.74629919868982 1.86846589298284e-08 -2.87837421637657 3.11921581471297e-13 mirMAP -0.223732992343918 3.37250597920076e-06 NA NA NA hsa-miR-330-3p FGFR1 0.876747334239085 0.00073709016089703 -2.87837421637657 3.11921581471297e-13 PITA;miRNATAP -0.559474382786579 2.73100688103047e-14 NA NA NA hsa-miR-330-5p FGFR1 1.15100069700871 4.85551805046014e-07 -2.87837421637657 3.11921581471297e-13 miRanda;miRNATAP -0.598697666333084 6.64556149251227e-13 NA NA NA hsa-miR-335-3p FGFR1 3.08791651139852 5.31309869723517e-12 -2.87837421637657 3.11921581471297e-13 mirMAP -0.228197239098805 6.49231469692864e-08 NA NA NA hsa-miR-361-5p FGFR1 0.971859117235239 5.30236555707088e-09 -2.87837421637657 3.11921581471297e-13 miRanda -0.92653502351532 4.53500138468749e-16 NA NA NA hsa-miR-455-5p FGFR1 2.2582442061694 1.43472128037398e-13 -2.87837421637657 3.11921581471297e-13 miRanda -0.195533414771426 0.00177055042135951 NA NA NA hsa-miR-532-5p FGFR1 1.55697650978597 1.57884735535196e-11 -2.87837421637657 3.11921581471297e-13 PITA -0.322395452372313 0.000108234147627559 NA NA NA hsa-miR-590-3p FGFR1 2.59289455139753 1.03200520972022e-21 -2.87837421637657 3.11921581471297e-13 miRanda;mirMAP -0.57572040519455 4.81539975802524e-17 NA NA NA hsa-miR-744-5p FGFR1 1.48254348878737 3.23019501613577e-09 -2.87837421637657 3.11921581471297e-13 miRNAWalker2_validate -0.538473651654813 1.02221972010418e-12 NA NA NA hsa-miR-93-5p FGFR1 3.03961860136032 1.11672209617395e-24 -2.87837421637657 3.11921581471297e-13 mirMAP -0.600996333108956 4.3413966207049e-24 NA NA NA hsa-let-7a-3p FGFR2 1.42015538786275 7.03375209382654e-13 -1.10510536599184 0.0128825317606034 miRNATAP -0.403668699840633 0.000151473399712384 NA NA NA hsa-let-7b-3p FGFR2 0.868207752019623 1.30460056774366e-05 -1.10510536599184 0.0128825317606034 mirMAP;miRNATAP -0.309687251123528 0.00423048135274253 NA NA NA hsa-miR-107 FGFR2 1.30977326593435 1.30372468603965e-11 -1.10510536599184 0.0128825317606034 PITA;miRanda -0.398153526215925 0.00027439034373613 NA NA NA hsa-miR-126-5p FGFR2 0.895338176458417 2.33372756450713e-05 -1.10510536599184 0.0128825317606034 mirMAP;miRNATAP -0.403452572621652 6.82252178653857e-05 NA NA NA hsa-miR-186-5p FGFR2 1.47445398888668 3.0781726595413e-15 -1.10510536599184 0.0128825317606034 miRNAWalker2_validate -0.471854892718397 2.53033898213571e-05 NA NA NA hsa-miR-193a-3p FGFR2 1.60460546928078 2.86169793322984e-07 -1.10510536599184 0.0128825317606034 miRanda -0.184992348766107 0.00659604280779591 NA NA NA hsa-miR-19b-1-5p FGFR2 2.57951428759379 4.31576118703427e-20 -1.10510536599184 0.0128825317606034 miRNAWalker2_validate;miRTarBase -0.4345309219133 4.77765562006864e-09 NA NA NA hsa-miR-324-5p FGFR2 2.95683728155095 1.32960514360912e-20 -1.10510536599184 0.0128825317606034 miRanda -0.24680525694008 0.000127710806173706 NA NA NA hsa-miR-338-3p FGFR2 0.453166438193782 0.144583389707558 -1.10510536599184 0.0128825317606034 miRanda;miRNATAP -0.263518769420772 0.000141261313872914 NA NA NA hsa-miR-423-3p FGFR2 2.57855385753676 9.19765570228097e-24 -1.10510536599184 0.0128825317606034 PITA;miRNATAP -0.233949308012158 0.00330874395567353 NA NA NA hsa-miR-590-3p FGFR2 2.59289455139753 1.03200520972022e-21 -1.10510536599184 0.0128825317606034 miRanda -0.311141579023723 6.00872154446622e-05 NA NA NA hsa-miR-628-5p FGFR2 0.799263053510813 2.28892357418044e-05 -1.10510536599184 0.0128825317606034 PITA;miRNATAP -0.568329203893148 5.54144600332728e-07 NA NA NA hsa-miR-100-5p FGFR3 -1.48442967087177 1.5610956769298e-05 1.15552976289114 0.0896174662454542 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.39236626068709 3.31966324164684e-05 23778527;25344675;26604796;26018508 Hypoxia regulates FGFR3 expression via HIF 1α and miR 100 and contributes to cell survival in non muscle invasive bladder cancer; We have previously investigated the role of microRNAs in bladder cancer and have shown that FGFR3 is a target of miR-100; In this study we investigated the effects of hypoxia on miR-100 and FGFR3 expression and the link between miR-100 and FGFR3 in hypoxia; Bladder cancer cell lines were exposed to normoxic or hypoxic conditions and examined for the expression of FGFR3 by quantitative PCR qPCR and western blotting and miR-100 by qPCR; The effect of FGFR3 and miR-100 on cell viability in two-dimensional 2-D and three-dimensional 3-D was examined by transfecting siRNA or mimic-100 respectively; Increased FGFR3 was also in part dependent on miR-100 levels which decreased in hypoxia; Hypoxia in part via suppression of miR-100 induces FGFR3 expression in bladder cancer both of which have an important role in maintaining cell viability under conditions of stress;MicroRNA 100 regulates pancreatic cancer cells growth and sensitivity to chemotherapy through targeting FGFR3; The predicted target of miR-100 fibroblast growth factor receptor 3 FGFR3 was downregulated by siRNA to examine its effect on pancreatic cancer cells; Luciferase essay showed FGFR3 was direct target of miR-100; FGFR3 was significantly downregulated by overexpressing miR-100 in pancreatic cancer cells and knocking down FGFR3 by siRNA exerted similar effect as miR-100; Our study demonstrated that miR-100 played an important role in pancreatic cancer development possibly through targeting FGFR3;Overexpression of miR 100 inhibits cell proliferation migration and chemosensitivity in human glioblastoma through FGFR3; Expression of fibroblast growth factor receptor 3 FGFR3 the bioinformatically predicted target of miR-100 was examined by Western blot in glioblastoma; FGFR3 was directly regulated by miR-100 in glioblastoma; Ectopically overexpressing FGFR3 was able to ameliorate the anticancer effects of upregulation of miR-100 on glioblastoma growth migration and chemosensitivity; Overexpressing miR-100 had anticancer effects on glioblastoma likely through regulation of FGFR3;Overexpression of miR 100 inhibits growth of osteosarcoma through FGFR3; Here we reported significantly higher levels of fibroblast growth factor receptor 3 FGFR3 and significantly lower levels of miR-100 in the OS specimen compared to those in the paired normal bone tissues; Bioinformatics analysis and luciferase reporter assay suggest that miR-100 binds to the 3'UTR of FGFR3 mRNA to prevent its translation; Taken together our data demonstrate that miR-100 may inhibit the growth of OS through FGFR3 poor survival;;; bladder cancer;pancreatic cancer;glioblastoma;sarcoma hsa-miR-142-3p FGFR3 2.75247908790621 1.45636065474764e-12 1.15552976289114 0.0896174662454542 miRanda -0.216798137380456 0.00854904538212289 NA NA NA hsa-miR-99a-5p FGFR3 -1.90541207788117 1.19082238183432e-05 1.15552976289114 0.0896174662454542 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.278809233789285 0.00018764039323491 23409016;24456664;23298836 Photofrin based photodynamic therapy and miR 99a transfection inhibited FGFR3 and PI3K/Akt signaling mechanisms to control growth of human glioblastoma In vitro and in vivo; Further photofrin based PDT followed by miR-99a transfection dramatically increased miR-99a expression and also increased apoptosis in glioblastoma cell cultures and drastically reduced tumor growth in athymic nude mice due to down regulation of fibroblast growth factor receptor 3 FGFR3 and PI3K/Akt signaling mechanisms leading to inhibition of cell proliferation and induction of molecular mechanisms of apoptosis;miR 99a promotes proliferation targeting FGFR3 in human epithelial ovarian cancer cells; Importantly fibroblast growth factor receptor 3 FGFR3 predicted to be one target gene of miR-99a using computational algorithms was higher in expression in EOC cells; Subsequently FGFR3 was proved to be direct target of miR-99a by dual luciferase assay; Furthermore overexpression of miR-99a dramatically suppressed expression level of FGFR3 at both mRNA and protein levels proving FGFR3 to be inversely correlated with miR-99a; Finally overexpression of miR-99a could significantly inhibit EOC cell proliferation in vitro by decreasing the expression of FGFR3 which also reduced the EOC cell growth after siRNA knockdown; Conclusively miR-99a expression was remarkably downregulated in serums tissues and cell and suppresses EOC cell proliferation by targeting FGFR3 suggesting miR-99a as a prospective prognosis marker and potential tumor suppressor for EOC therapeutics;The tumorigenic FGFR3 TACC3 gene fusion escapes miR 99a regulation in glioblastoma; The fusion caused by tandem duplication on 4p16.3 led to the loss of the 3'-UTR of FGFR3 blocking gene regulation of miR-99a and enhancing expression of the fusion gene ;worse prognosis; glioblastoma;ovarian cancer;glioblastoma hsa-let-7b-5p FLNA 0.604314269683977 0.00140009936153214 -2.62738684988354 4.5847076562045e-13 miRNAWalker2_validate -0.403177193243923 2.55918754075918e-05 NA NA NA hsa-miR-149-5p FLNA 2.94200492826326 4.93436498919036e-14 -2.62738684988354 4.5847076562045e-13 miRNAWalker2_validate -0.416191196137286 1.5962274408455e-22 NA NA NA hsa-miR-16-5p FLNA 1.75824877145857 1.68592440033108e-16 -2.62738684988354 4.5847076562045e-13 miRNAWalker2_validate -0.821633719130985 2.66124157726764e-26 NA NA NA hsa-miR-193b-3p FLNA 2.25711804611899 4.1940744806631e-14 -2.62738684988354 4.5847076562045e-13 miRNAWalker2_validate -0.15583811174074 0.00802902833961969 NA NA NA hsa-miR-200c-3p FLNA 3.50132673580082 2.42716349086937e-15 -2.62738684988354 4.5847076562045e-13 miRNAWalker2_validate -0.573278326556171 6.53243471319789e-65 NA NA NA hsa-miR-20a-5p FLNA 3.15577933619191 4.19753346442454e-25 -2.62738684988354 4.5847076562045e-13 miRNAWalker2_validate -0.564800020648001 6.19255464701142e-27 NA NA NA hsa-miR-324-5p FLNA 2.95683728155095 1.32960514360912e-20 -2.62738684988354 4.5847076562045e-13 miRNAWalker2_validate -0.59678532241766 1.71478663638803e-32 NA NA NA hsa-miR-331-3p FLNA 2.28379581858927 1.99663919173155e-18 -2.62738684988354 4.5847076562045e-13 miRNAWalker2_validate -0.745555941056727 9.58027751437445e-34 NA NA NA hsa-miR-378a-3p FLNA -0.10995720000828 0.716188270032681 -2.62738684988354 4.5847076562045e-13 miRNAWalker2_validate -0.491191935825633 1.88782049586854e-17 NA NA NA hsa-miR-484 FLNA 1.81844463411787 1.82951571230938e-15 -2.62738684988354 4.5847076562045e-13 miRNAWalker2_validate -0.831848183638064 2.17819747551506e-31 NA NA NA hsa-miR-92a-3p FLNA 2.06460102658973 1.44784291084757e-19 -2.62738684988354 4.5847076562045e-13 miRNAWalker2_validate -0.811332613287438 2.90624250691799e-30 NA NA NA hsa-let-7c-5p FLNB -2.07847142524506 5.51224567263294e-09 0.258056001614433 0.225745048816205 miRNAWalker2_validate -0.137529348169388 9.59645768630222e-07 NA NA NA hsa-miR-145-5p FLNB -1.55259331973517 9.97889123247165e-07 0.258056001614433 0.225745048816205 MirTarget;miRNATAP -0.102386339271664 0.00137994907691718 NA NA NA hsa-miR-493-5p FLNB 0.847772103665986 0.00528678068747754 0.258056001614433 0.225745048816205 mirMAP -0.121690310599879 0.000321210755599252 NA NA NA hsa-miR-19a-3p FLNC 3.42309334186656 3.02671914353412e-28 -5.35559193544998 4.14193594656507e-16 miRNATAP -0.956044859412079 3.55529902948285e-24 NA NA NA hsa-miR-19b-3p FLNC 2.49529833021187 1.57028265846699e-23 -5.35559193544998 4.14193594656507e-16 miRNATAP -1.30952642296644 9.16288456061389e-29 NA NA NA hsa-miR-320a FLNC 0.438165828017084 0.0390159073347133 -5.35559193544998 4.14193594656507e-16 PITA;miRanda;miRNATAP -1.17117905222032 1.51170997695725e-14 NA NA NA hsa-miR-320b FLNC 1.55692969039548 1.41071034251915e-08 -5.35559193544998 4.14193594656507e-16 PITA;miRanda;miRNATAP -1.0505598034493 2.20614638122585e-20 NA NA NA hsa-miR-326 FLNC 0.715313016136042 0.0610265683213359 -5.35559193544998 4.14193594656507e-16 miRanda -0.241421856871445 0.00550024083741663 NA NA NA hsa-miR-330-5p FLNC 1.15100069700871 4.85551805046014e-07 -5.35559193544998 4.14193594656507e-16 miRanda -1.13713440185912 2.48558963920034e-16 NA NA NA hsa-miR-454-3p FLNC 2.47234127820054 1.12878018736016e-21 -5.35559193544998 4.14193594656507e-16 miRNAWalker2_validate -1.33005883038113 5.44970907807184e-30 NA NA NA hsa-miR-455-5p FLNC 2.2582442061694 1.43472128037398e-13 -5.35559193544998 4.14193594656507e-16 miRanda -0.463238876179597 9.28870312024586e-06 NA NA NA hsa-miR-592 FLNC 1.51765968871077 0.000636335248013204 -5.35559193544998 4.14193594656507e-16 mirMAP -0.687401133697104 1.0567525348937e-21 NA NA NA hsa-miR-142-5p FOS 1.17581605694506 0.0018174701991234 -3.39745351917485 1.25524442357693e-17 PITA -0.168953006320546 0.00138415874660884 NA NA NA hsa-miR-155-5p FOS 1.20164021433135 0.00086170622431261 -3.39745351917485 1.25524442357693e-17 MirTarget -0.192743317837579 0.000474239003861496 23693020 Also S100P treatment stimulated the enrichment of c-Fos an AP-1 family member at the miR-155 host gene promoter site colon cancer hsa-miR-181a-5p FOS 2.29556023480783 1.8138457900616e-21 -3.39745351917485 1.25524442357693e-17 miRNAWalker2_validate;miRTarBase;miRNATAP -0.406931044177245 2.15032589233814e-07 NA NA NA hsa-miR-181b-5p FOS 2.49307679431293 3.92829250217627e-20 -3.39745351917485 1.25524442357693e-17 miRNATAP -0.347263888028368 6.97361305464486e-07 NA NA NA hsa-miR-181c-5p FOS 1.58587920618301 1.57506918816933e-10 -3.39745351917485 1.25524442357693e-17 miRNATAP -0.389336160042193 7.46012681409647e-07 NA NA NA hsa-miR-192-5p FOS 2.69002528723195 1.22990188194432e-16 -3.39745351917485 1.25524442357693e-17 miRNAWalker2_validate -0.247944413799652 2.71034229894278e-05 NA NA NA hsa-miR-199a-3p FOS 0.640600337515787 0.0380326905134914 -3.39745351917485 1.25524442357693e-17 MirTarget;PITA -0.193748215738404 0.00283127005200651 NA NA NA hsa-miR-199b-3p FOS 0.643923492750702 0.0371742251925406 -3.39745351917485 1.25524442357693e-17 MirTarget;PITA;miRNATAP -0.193944745208572 0.00278339966177455 NA NA NA hsa-miR-222-3p FOS 0.851783756239071 0.00266783568486918 -3.39745351917485 1.25524442357693e-17 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.233914002507589 0.000901382653088722 NA NA NA hsa-miR-29b-3p FOS 1.65828197923813 1.02676780888141e-09 -3.39745351917485 1.25524442357693e-17 miRNAWalker2_validate;MirTarget;miRNATAP -0.19998058463295 0.00584509977497633 NA NA NA hsa-miR-3065-3p FOS 2.16221780121195 9.65525739884541e-09 -3.39745351917485 1.25524442357693e-17 MirTarget;miRNATAP -0.186726493959471 0.000334737358276023 NA NA NA hsa-miR-335-5p FOS 1.77247705492746 2.22457658872091e-06 -3.39745351917485 1.25524442357693e-17 miRNAWalker2_validate -0.179920825828979 0.000646944858498294 NA NA NA hsa-miR-361-5p FOS 0.971859117235239 5.30236555707088e-09 -3.39745351917485 1.25524442357693e-17 miRanda -0.484687813338039 5.02065687497632e-05 NA NA NA hsa-miR-362-3p FOS 2.0756816987665 3.89026064579331e-12 -3.39745351917485 1.25524442357693e-17 miRanda -0.338731817794186 4.09940306270337e-07 NA NA NA hsa-miR-424-3p FOS 0.991234037658669 0.000358786932730602 -3.39745351917485 1.25524442357693e-17 MirTarget;miRNATAP -0.215990598190096 0.0027604322604624 NA NA NA hsa-miR-501-3p FOS 1.83132758513743 1.10971547702065e-10 -3.39745351917485 1.25524442357693e-17 MirTarget;PITA;miRNATAP -0.26869102191487 9.6048953777837e-05 NA NA NA hsa-miR-502-3p FOS 1.50560877085049 1.2647489756373e-11 -3.39745351917485 1.25524442357693e-17 MirTarget;PITA;miRNATAP -0.409606540747994 3.08619071848891e-06 NA NA NA hsa-miR-576-5p FOS 2.20467023993664 3.4053475193793e-19 -3.39745351917485 1.25524442357693e-17 PITA -0.371990925678645 1.58603505214874e-06 NA NA NA hsa-miR-589-3p FOS 2.51971841868825 2.39125940264107e-11 -3.39745351917485 1.25524442357693e-17 MirTarget -0.271360671556706 3.63028731887112e-06 NA NA NA hsa-miR-590-3p FOS 2.59289455139753 1.03200520972022e-21 -3.39745351917485 1.25524442357693e-17 miRanda -0.527553188053258 6.91172092082184e-14 NA NA NA hsa-miR-130b-3p GADD45A 3.5350292994509 1.73934183852569e-27 -0.835839078652441 0.000140836693353512 MirTarget;miRNATAP -0.17218937101763 1.35434055056965e-08 NA NA NA hsa-miR-148b-3p GADD45A 1.97815018171325 6.07715327281595e-26 -0.835839078652441 0.000140836693353512 MirTarget -0.24164313540326 6.68989940877406e-06 NA NA NA hsa-miR-301a-3p GADD45A 2.81024345929638 2.29784847962242e-17 -0.835839078652441 0.000140836693353512 MirTarget;miRNATAP -0.112998413130989 0.000548458732723422 NA NA NA hsa-miR-324-5p GADD45A 2.95683728155095 1.32960514360912e-20 -0.835839078652441 0.000140836693353512 miRanda -0.112457495567732 0.000439233642516274 NA NA NA hsa-miR-421 GADD45A 1.17791565395543 6.78526676976629e-06 -0.835839078652441 0.000140836693353512 miRanda -0.133567846694638 0.00100215803079645 NA NA NA hsa-miR-454-3p GADD45A 2.47234127820054 1.12878018736016e-21 -0.835839078652441 0.000140836693353512 MirTarget;miRNATAP -0.123232081874385 0.00233561552908576 NA NA NA hsa-miR-590-3p GADD45A 2.59289455139753 1.03200520972022e-21 -0.835839078652441 0.000140836693353512 miRanda;mirMAP -0.116878603221423 0.00246827969058347 NA NA NA hsa-miR-1976 GADD45B 2.06550563678192 7.81396978619772e-18 -2.10522351126521 1.24009438337654e-11 miRNATAP -0.438571553390836 3.56919131064351e-13 NA NA NA hsa-miR-324-3p GADD45B 2.08739139768981 3.11885987067952e-13 -2.10522351126521 1.24009438337654e-11 MirTarget;miRNATAP -0.529388083839586 5.82182378729412e-27 NA NA NA hsa-miR-590-3p GADD45B 2.59289455139753 1.03200520972022e-21 -2.10522351126521 1.24009438337654e-11 miRanda -0.441564740260131 2.37587329223105e-16 NA NA NA hsa-miR-1976 GADD45G 2.06550563678192 7.81396978619772e-18 -1.14052103223901 0.000287911213048388 MirTarget -0.223301232794066 0.000270386119057603 NA NA NA hsa-miR-320a GADD45G 0.438165828017084 0.0390159073347133 -1.14052103223901 0.000287911213048388 miRanda -0.202148212458203 0.00541824995825031 NA NA NA hsa-miR-320b GADD45G 1.55692969039548 1.41071034251915e-08 -1.14052103223901 0.000287911213048388 miRanda -0.18771629419395 0.000624415279589848 NA NA NA hsa-miR-429 GADD45G 4.48815175680773 2.44117492218206e-17 -1.14052103223901 0.000287911213048388 miRNATAP -0.111263953867699 5.40997990169216e-05 NA NA NA hsa-miR-141-3p GNA12 5.02396127982626 2.19224509139725e-24 -0.327866213861197 0.0839906551813244 mirMAP -0.159733729112464 9.55959524392438e-22 NA NA NA hsa-miR-15a-5p GNA12 2.34669284378787 1.69544424500258e-23 -0.327866213861197 0.0839906551813244 MirTarget -0.215311052450744 3.71511576989072e-09 NA NA NA hsa-miR-15b-5p GNA12 1.57112623124278 9.14247846750597e-13 -0.327866213861197 0.0839906551813244 MirTarget -0.157437448444998 0.000107114121274889 NA NA NA hsa-miR-16-5p GNA12 1.75824877145857 1.68592440033108e-16 -0.327866213861197 0.0839906551813244 MirTarget -0.146402910320401 0.000431269055557148 NA NA NA hsa-miR-181c-5p GNA12 1.58587920618301 1.57506918816933e-10 -0.327866213861197 0.0839906551813244 mirMAP -0.139123898696493 0.000120953087051844 NA NA NA hsa-miR-1976 GNA12 2.06550563678192 7.81396978619772e-18 -0.327866213861197 0.0839906551813244 miRNATAP -0.113194350728467 0.00209082281274727 NA NA NA hsa-miR-200a-3p GNA12 4.59434485520731 6.38952518573476e-18 -0.327866213861197 0.0839906551813244 mirMAP -0.168030535972189 1.50517967977493e-27 NA NA NA hsa-miR-23b-3p GNA12 -0.251132426825047 0.150200321210792 -0.327866213861197 0.0839906551813244 miRNAWalker2_validate -0.195824609597045 0.000229772988348895 NA NA NA hsa-miR-30d-3p GNA12 0.977747550180601 4.3048212205381e-05 -0.327866213861197 0.0839906551813244 MirTarget -0.213956637025955 1.45368101118543e-08 NA NA NA hsa-miR-30e-3p GNA12 -0.215663037684509 0.235375122783546 -0.327866213861197 0.0839906551813244 MirTarget -0.269301274868991 9.95556029232702e-08 NA NA NA hsa-miR-320a GNA12 0.438165828017084 0.0390159073347133 -0.327866213861197 0.0839906551813244 mirMAP -0.285897506619717 1.87175560728399e-11 NA NA NA hsa-miR-320b GNA12 1.55692969039548 1.41071034251915e-08 -0.327866213861197 0.0839906551813244 mirMAP -0.131314535331568 6.13804343086984e-05 NA NA NA hsa-miR-33a-3p GNA12 1.72765312072219 1.51784443453521e-07 -0.327866213861197 0.0839906551813244 mirMAP -0.135208016347045 6.58132930873379e-06 NA NA NA hsa-miR-3913-5p GNA12 2.44353493655328 8.95279496632448e-15 -0.327866213861197 0.0839906551813244 mirMAP -0.184838234724502 7.9458249613759e-11 NA NA NA hsa-miR-423-5p GNA12 0.963563145758616 9.86109015204915e-07 -0.327866213861197 0.0839906551813244 MirTarget -0.313582129416695 4.9368208830366e-12 NA NA NA hsa-miR-93-5p GNA12 3.03961860136032 1.11672209617395e-24 -0.327866213861197 0.0839906551813244 miRNAWalker2_validate -0.148951657753972 2.52100329582818e-07 NA NA NA hsa-miR-98-5p GNA12 1.11154309866014 1.24143909012085e-08 -0.327866213861197 0.0839906551813244 miRNAWalker2_validate -0.193794535751143 2.93494434374653e-05 NA NA NA hsa-miR-107 GNG12 1.30977326593435 1.30372468603965e-11 -1.00694431810149 1.61985728260734e-06 miRanda -0.325194911035192 2.35617021655576e-10 NA NA NA hsa-miR-126-5p GNG12 0.895338176458417 2.33372756450713e-05 -1.00694431810149 1.61985728260734e-06 mirMAP -0.216265925507577 7.06592392108692e-06 NA NA NA hsa-miR-140-5p GNG12 0.844753502512594 3.73722278438606e-05 -1.00694431810149 1.61985728260734e-06 PITA;miRanda -0.215923167393918 1.48186394256009e-05 NA NA NA hsa-miR-186-5p GNG12 1.47445398888668 3.0781726595413e-15 -1.00694431810149 1.61985728260734e-06 miRNAWalker2_validate -0.290324396097542 4.28690446751612e-08 NA NA NA hsa-miR-30d-3p GNG12 0.977747550180601 4.3048212205381e-05 -1.00694431810149 1.61985728260734e-06 mirMAP -0.268445146648906 1.78296007701357e-10 NA NA NA hsa-miR-30e-3p GNG12 -0.215663037684509 0.235375122783546 -1.00694431810149 1.61985728260734e-06 mirMAP -0.232213452778567 4.65209274857153e-05 NA NA NA hsa-miR-374a-5p GNG12 0.484615721953736 0.0042981729815149 -1.00694431810149 1.61985728260734e-06 mirMAP -0.213351975656957 0.000483455395337009 NA NA NA hsa-miR-409-5p GNG12 1.56949123847358 5.91654175754272e-07 -1.00694431810149 1.61985728260734e-06 PITA -0.165828998572686 9.83801581754514e-07 NA NA NA hsa-miR-423-5p GNG12 0.963563145758616 9.86109015204915e-07 -1.00694431810149 1.61985728260734e-06 miRNAWalker2_validate -0.340366952806888 2.37757447594555e-11 NA NA NA hsa-miR-429 GNG12 4.48815175680773 2.44117492218206e-17 -1.00694431810149 1.61985728260734e-06 miRanda -0.161475795423235 1.09474596004218e-19 NA NA NA hsa-miR-508-3p GNG12 1.05493034310846 0.0393857095042515 -1.00694431810149 1.61985728260734e-06 mirMAP -0.109947026301814 5.08686689387732e-08 NA NA NA hsa-miR-542-3p GNG12 1.18832665895751 1.98700670691565e-07 -1.00694431810149 1.61985728260734e-06 miRanda -0.168110144177005 0.000154291626655441 NA NA NA hsa-miR-590-3p GNG12 2.59289455139753 1.03200520972022e-21 -1.00694431810149 1.61985728260734e-06 miRanda;mirMAP -0.204473638976492 2.35752221652166e-08 NA NA NA hsa-miR-590-5p GNG12 3.18300989862077 2.06813568597893e-26 -1.00694431810149 1.61985728260734e-06 PITA -0.219549663318668 1.24972971345505e-11 NA NA NA hsa-miR-96-5p GNG12 4.89433085814374 1.92000659886961e-31 -1.00694431810149 1.61985728260734e-06 TargetScan -0.203127178908812 7.44354635001805e-20 NA NA NA hsa-miR-320a GRB2 0.438165828017084 0.0390159073347133 0.0788721517658564 0.390920910556044 MirTarget;miRanda;mirMAP;miRNATAP -0.105017257701224 3.72382950677321e-07 NA NA NA hsa-miR-143-3p HRAS -2.5789192793377 1.55518999614836e-14 0.623195449314017 0.00175543589552248 miRNAWalker2_validate;miRTarBase -0.162589208332201 3.09270971499286e-09 21276449 The Evi1 microRNA 143 K Ras axis in colon cancer colon cancer hsa-miR-423-5p HSPA1L 0.963563145758616 9.86109015204915e-07 -0.640026608609516 0.000137141838435733 miRNATAP -0.113989397364638 0.00586156954155358 NA NA NA hsa-miR-590-3p HSPA1L 2.59289455139753 1.03200520972022e-21 -0.640026608609516 0.000137141838435733 miRanda -0.143604652892098 8.86951476251724e-07 NA NA NA hsa-miR-192-5p HSPA2 2.69002528723195 1.22990188194432e-16 -2.1645580340455 4.46196299882315e-11 miRNAWalker2_validate -0.208321478474037 1.40388272164444e-05 NA NA NA hsa-miR-339-5p HSPA2 2.68710938429893 3.03134080808154e-16 -2.1645580340455 4.46196299882315e-11 miRanda -0.301242248192111 1.23028890882003e-10 NA NA NA hsa-miR-450b-5p HSPA2 1.69244418548325 1.68064054148881e-10 -2.1645580340455 4.46196299882315e-11 miRNATAP -0.172206107686634 0.00429757268740456 NA NA NA hsa-miR-500a-3p HSPA2 1.47161373123699 5.30571342631915e-09 -2.1645580340455 4.46196299882315e-11 miRNATAP -0.257946308248826 4.68817512328947e-05 NA NA NA hsa-miR-7-1-3p HSPA2 1.84950311431067 1.25300363397654e-13 -2.1645580340455 4.46196299882315e-11 mirMAP -0.310425120846618 8.21369341096794e-07 NA NA NA hsa-miR-96-5p HSPA2 4.89433085814374 1.92000659886961e-31 -2.1645580340455 4.46196299882315e-11 TargetScan -0.260251407371469 4.45804235107461e-13 NA NA NA hsa-miR-10a-5p HSPA8 1.15016989191194 0.00372037233992369 -0.345676743146896 0.0777824648559953 miRNAWalker2_validate -0.165320511903093 1.02204917301732e-12 NA NA NA hsa-miR-151a-5p HSPA8 2.32422038747303 2.66226949101065e-18 -0.345676743146896 0.0777824648559953 miRNAWalker2_validate -0.101226606355912 0.00305226795858916 NA NA NA hsa-miR-320a HSPA8 0.438165828017084 0.0390159073347133 -0.345676743146896 0.0777824648559953 miRNAWalker2_validate -0.232386770478539 1.70721687673412e-07 NA NA NA hsa-miR-429 HSPA8 4.48815175680773 2.44117492218206e-17 -0.345676743146896 0.0777824648559953 miRNATAP -0.108772293254945 9.33193134970045e-11 NA NA NA hsa-miR-146b-5p IKBKB 1.75587235896724 1.15724631266659e-07 -0.00227190214342876 0.988714147115007 miRanda -0.12253940493918 7.13410135054121e-08 NA NA NA hsa-miR-30d-3p IL1B 0.977747550180601 4.3048212205381e-05 0.039301070315787 0.942663363341787 MirTarget -0.351425913519885 0.00142656977660209 NA NA NA hsa-miR-130b-5p IL1R1 2.9963110846538 1.98883029416455e-18 -0.754392858754991 0.00819157634786962 mirMAP -0.265810866002561 8.60645196440847e-12 NA NA NA hsa-miR-17-3p IL1R1 2.2704817679209 1.1667437320211e-22 -0.754392858754991 0.00819157634786962 mirMAP -0.457437413596706 7.7813507528449e-17 NA NA NA hsa-miR-181b-5p IL1R1 2.49307679431293 3.92829250217627e-20 -0.754392858754991 0.00819157634786962 mirMAP -0.144149390460215 0.00312034364681948 NA NA NA hsa-miR-186-5p IL1R1 1.47445398888668 3.0781726595413e-15 -0.754392858754991 0.00819157634786962 mirMAP -0.413980327390447 6.22085295917803e-09 NA NA NA hsa-miR-192-5p IL1R1 2.69002528723195 1.22990188194432e-16 -0.754392858754991 0.00819157634786962 miRNAWalker2_validate -0.18623904564978 4.77161512216095e-06 NA NA NA hsa-miR-197-3p IL1R1 1.75733174019505 8.88576793100499e-13 -0.754392858754991 0.00819157634786962 miRNAWalker2_validate -0.245286619557537 6.97172291808552e-06 NA NA NA hsa-miR-24-3p IL1R1 0.99989036772428 1.35595013650376e-07 -0.754392858754991 0.00819157634786962 miRNATAP -0.329790317110319 4.8735388331152e-06 NA NA NA hsa-miR-26b-5p IL1R1 0.885393662798425 3.2116297961629e-06 -0.754392858754991 0.00819157634786962 mirMAP -0.287058738544535 7.46900640431975e-05 NA NA NA hsa-miR-30d-3p IL1R1 0.977747550180601 4.3048212205381e-05 -0.754392858754991 0.00819157634786962 mirMAP -0.207730148083987 0.000312780009684164 NA NA NA hsa-miR-335-3p IL1R1 3.08791651139852 5.31309869723517e-12 -0.754392858754991 0.00819157634786962 mirMAP -0.128248188751599 1.75690264294768e-05 NA NA NA hsa-miR-361-5p IL1R1 0.971859117235239 5.30236555707088e-09 -0.754392858754991 0.00819157634786962 miRanda -0.498319115587793 9.79775892914811e-10 NA NA NA hsa-miR-590-3p IL1R1 2.59289455139753 1.03200520972022e-21 -0.754392858754991 0.00819157634786962 miRanda;miRNATAP -0.268420918425037 5.48871203423167e-08 NA NA NA hsa-miR-944 IL1R1 2.91186649218281 1.31574753528144e-06 -0.754392858754991 0.00819157634786962 mirMAP -0.118403143401936 3.14768683036805e-07 NA NA NA hsa-miR-101-3p JUN 0.522819989585461 0.00375627731618038 -2.04611084807692 9.1524625995215e-13 miRNAWalker2_validate -0.362533052186516 4.72957409908478e-06 NA NA NA hsa-miR-141-3p JUN 5.02396127982626 2.19224509139725e-24 -2.04611084807692 9.1524625995215e-13 miRNATAP -0.202238939720509 1.9524950223322e-14 NA NA NA hsa-miR-149-5p JUN 2.94200492826326 4.93436498919036e-14 -2.04611084807692 9.1524625995215e-13 miRNAWalker2_validate;miRNATAP -0.155172431476894 9.83577829040368e-06 NA NA NA hsa-miR-15a-5p JUN 2.34669284378787 1.69544424500258e-23 -2.04611084807692 9.1524625995215e-13 miRNAWalker2_validate -0.322829003344663 1.37042285263916e-08 NA NA NA hsa-miR-16-5p JUN 1.75824877145857 1.68592440033108e-16 -2.04611084807692 9.1524625995215e-13 miRNAWalker2_validate -0.384340701644607 1.66878593693069e-09 NA NA NA hsa-miR-200a-3p JUN 4.59434485520731 6.38952518573476e-18 -2.04611084807692 9.1524625995215e-13 miRNATAP -0.185345884656907 9.93412020536435e-14 NA NA NA hsa-miR-200b-3p JUN 3.78235093249346 3.18343003239465e-14 -2.04611084807692 9.1524625995215e-13 MirTarget;TargetScan -0.190113959616059 1.82414115729818e-12 NA NA NA hsa-miR-200c-3p JUN 3.50132673580082 2.42716349086937e-15 -2.04611084807692 9.1524625995215e-13 MirTarget -0.195019704023245 1.57363395803084e-10 NA NA NA hsa-miR-26b-5p JUN 0.885393662798425 3.2116297961629e-06 -2.04611084807692 9.1524625995215e-13 miRNAWalker2_validate -0.246116506815496 0.00101325681187835 21901137;27078844 When c-Jun N-terminal kinase activity was inhibited using SP600125 expression of miR-26b was induced following γ-irradiation in H1299 cells;MicroRNA 26b inhibits tumor metastasis by targeting the KPNA2/c jun pathway in human gastric cancer ;metastasis lung cancer;gastric cancer hsa-miR-29c-3p JUN -0.00968972577705429 0.97099586346872 -2.04611084807692 9.1524625995215e-13 miRNAWalker2_validate -0.270579553256343 3.66051574994211e-07 NA NA NA hsa-miR-32-5p JUN 2.34056473219422 6.24134585974322e-20 -2.04611084807692 9.1524625995215e-13 miRNATAP -0.413566434466745 1.10620082409085e-15 NA NA NA hsa-miR-342-3p JUN 1.49115144672245 1.43879249744621e-07 -2.04611084807692 9.1524625995215e-13 miRNAWalker2_validate -0.133321520548688 0.00731127636739181 NA NA NA hsa-miR-34a-3p JUN 1.75590866103657 8.02801510630657e-09 -2.04611084807692 9.1524625995215e-13 MirTarget -0.279858707540387 3.1061995990995e-08 NA NA NA hsa-miR-429 JUN 4.48815175680773 2.44117492218206e-17 -2.04611084807692 9.1524625995215e-13 MirTarget;PITA;miRanda;miRNATAP -0.188635161083758 5.14832375488061e-14 NA NA NA hsa-miR-455-3p JUN 3.06093594997644 3.54590649799868e-16 -2.04611084807692 9.1524625995215e-13 miRNATAP -0.112839225766699 0.00201102151546805 NA NA NA hsa-miR-501-5p JUN 1.93654809410041 1.3779381780759e-10 -2.04611084807692 9.1524625995215e-13 MirTarget;PITA;miRNATAP -0.24236112135519 2.74349787240435e-07 NA NA NA hsa-miR-542-3p JUN 1.18832665895751 1.98700670691565e-07 -2.04611084807692 9.1524625995215e-13 miRanda -0.2224781000711 0.000312275738377628 NA NA NA hsa-miR-590-3p JUN 2.59289455139753 1.03200520972022e-21 -2.04611084807692 9.1524625995215e-13 miRanda -0.362021445664138 5.65305416742662e-13 NA NA NA hsa-miR-92a-3p JUN 2.06460102658973 1.44784291084757e-19 -2.04611084807692 9.1524625995215e-13 miRNATAP -0.395074792110845 1.74644010636679e-11 NA NA NA hsa-miR-93-5p JUN 3.03961860136032 1.11672209617395e-24 -2.04611084807692 9.1524625995215e-13 miRNAWalker2_validate -0.361575830576226 1.64388759918119e-16 NA NA NA hsa-miR-940 JUN 3.21011374578759 2.7923171128495e-14 -2.04611084807692 9.1524625995215e-13 MirTarget;PITA;miRNATAP -0.231773307807484 3.31037401763421e-11 NA NA NA hsa-miR-101-3p MAP2K1 0.522819989585461 0.00375627731618038 0.329146605656592 0.0110879553061078 miRNAWalker2_validate -0.179174585612232 2.32589570104786e-07 NA NA NA hsa-miR-30c-5p MAP2K1 0.778774633108 0.000285599212429136 0.329146605656592 0.0110879553061078 miRNAWalker2_validate -0.1435696131991 6.86626187272449e-07 NA NA NA hsa-miR-107 MAP2K3 1.30977326593435 1.30372468603965e-11 -0.371592359447536 0.0240168762541208 miRNATAP -0.136064340361546 0.00076977280228005 NA NA NA hsa-miR-107 MAP2K5 1.30977326593435 1.30372468603965e-11 -0.370420848933653 0.000676233259814945 miRanda -0.116846926963285 1.15385584632172e-05 NA NA NA hsa-miR-125a-5p MAP3K1 0.599529391575274 0.0102300147180307 0.427069954621904 0.0352041986280003 miRNAWalker2_validate -0.126195148873375 0.00275477598947122 NA NA NA hsa-miR-106b-5p MAP3K12 2.46782146831112 1.36171495805632e-23 -0.856121644680553 0.00031269192719719 MirTarget -0.210234099741897 1.88683018324808e-06 NA NA NA hsa-miR-130a-3p MAP3K12 2.02021855058359 1.26427102520415e-11 -0.856121644680553 0.00031269192719719 MirTarget;miRNATAP -0.170506780539444 5.62397112344327e-06 NA NA NA hsa-miR-130b-3p MAP3K12 3.5350292994509 1.73934183852569e-27 -0.856121644680553 0.00031269192719719 MirTarget;miRNATAP -0.129710644904985 8.91972645943553e-05 NA NA NA hsa-miR-17-5p MAP3K12 3.2710598467455 9.93128340539455e-27 -0.856121644680553 0.00031269192719719 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.242118349756834 2.81444245647764e-12 NA NA NA hsa-miR-186-5p MAP3K12 1.47445398888668 3.0781726595413e-15 -0.856121644680553 0.00031269192719719 MirTarget -0.288039081795024 1.49544766147262e-06 NA NA NA hsa-miR-19a-3p MAP3K12 3.42309334186656 3.02671914353412e-28 -0.856121644680553 0.00031269192719719 MirTarget -0.213814868418388 3.84048551402459e-10 NA NA NA hsa-miR-19b-3p MAP3K12 2.49529833021187 1.57028265846699e-23 -0.856121644680553 0.00031269192719719 MirTarget -0.275415870805036 1.67206865768792e-10 NA NA NA hsa-miR-20a-5p MAP3K12 3.15577933619191 4.19753346442454e-25 -0.856121644680553 0.00031269192719719 miRNAWalker2_validate;miRTarBase;MirTarget -0.220597301553485 3.17888742719191e-10 NA NA NA hsa-miR-26b-5p MAP3K12 0.885393662798425 3.2116297961629e-06 -0.856121644680553 0.00031269192719719 miRNAWalker2_validate -0.208728182302643 0.000578893162578219 NA NA NA hsa-miR-27a-3p MAP3K12 1.66542180327138 4.93775737894805e-13 -0.856121644680553 0.00031269192719719 miRNATAP -0.253574872722183 1.66099827078101e-07 NA NA NA hsa-miR-27b-3p MAP3K12 0.196007704287769 0.295630157035388 -0.856121644680553 0.00031269192719719 miRNATAP -0.169002104388256 0.00684605130645394 NA NA NA hsa-miR-301a-3p MAP3K12 2.81024345929638 2.29784847962242e-17 -0.856121644680553 0.00031269192719719 MirTarget;miRNATAP -0.118009870275415 0.000846834851864276 NA NA NA hsa-miR-324-3p MAP3K12 2.08739139768981 3.11885987067952e-13 -0.856121644680553 0.00031269192719719 MirTarget -0.145870638545058 0.000193175805021989 NA NA NA hsa-miR-454-3p MAP3K12 2.47234127820054 1.12878018736016e-21 -0.856121644680553 0.00031269192719719 MirTarget -0.180462792719081 3.43423586229214e-05 NA NA NA hsa-miR-590-3p MAP3K12 2.59289455139753 1.03200520972022e-21 -0.856121644680553 0.00031269192719719 miRanda -0.282249194475568 4.59506431254292e-12 NA NA NA hsa-miR-671-3p MAP3K12 2.20199226665068 7.0886613366934e-16 -0.856121644680553 0.00031269192719719 PITA -0.161029066287111 7.96698146294939e-05 NA NA NA hsa-miR-93-5p MAP3K12 3.03961860136032 1.11672209617395e-24 -0.856121644680553 0.00031269192719719 MirTarget -0.158274914682431 1.51067270273959e-05 NA NA NA hsa-miR-125b-5p MAP3K13 -1.16462950151259 0.000288900271798384 0.0789266280328784 0.789464978516727 miRNATAP -0.122469019003326 0.00561332960537856 NA NA NA hsa-miR-1271-5p MAP3K13 0.970418832993172 0.000609742584380688 0.0789266280328784 0.789464978516727 mirMAP -0.133482053224248 0.0081378639238516 NA NA NA hsa-miR-139-5p MAP3K13 -1.52606598644743 1.20474151350665e-08 0.0789266280328784 0.789464978516727 miRanda -0.137909637651281 0.00876039575222123 NA NA NA hsa-miR-374a-3p MAP3K13 0.533309330504947 0.00192918429705142 0.0789266280328784 0.789464978516727 mirMAP -0.287204848309896 0.000608084670797659 NA NA NA hsa-miR-539-5p MAP3K13 0.95216780650456 0.00284373332122135 0.0789266280328784 0.789464978516727 mirMAP -0.132037334925622 0.00326664521674991 NA NA NA hsa-miR-106b-5p MAP3K14 2.46782146831112 1.36171495805632e-23 -0.929542138683687 1.31735308419243e-05 MirTarget -0.19000303078406 1.7530926860456e-06 NA NA NA hsa-miR-17-5p MAP3K14 3.2710598467455 9.93128340539455e-27 -0.929542138683687 1.31735308419243e-05 MirTarget -0.10840260212945 0.000682220817217628 NA NA NA hsa-miR-185-3p MAP3K14 2.3922478518806 1.3373426768452e-14 -0.929542138683687 1.31735308419243e-05 MirTarget -0.129581834416974 6.081635091056e-05 NA NA NA hsa-miR-2110 MAP3K14 1.16625590651194 6.4784195289885e-05 -0.929542138683687 1.31735308419243e-05 MirTarget -0.119162411446147 0.00175262129581408 NA NA NA hsa-miR-331-3p MAP3K14 2.28379581858927 1.99663919173155e-18 -0.929542138683687 1.31735308419243e-05 MirTarget -0.177987296479208 2.93504280390057e-06 NA NA NA hsa-miR-34a-5p MAP3K14 1.9016323452565 1.43092834643601e-14 -0.929542138683687 1.31735308419243e-05 MirTarget -0.168509021928338 3.5079349902853e-05 NA NA NA hsa-miR-423-5p MAP3K14 0.963563145758616 9.86109015204915e-07 -0.929542138683687 1.31735308419243e-05 MirTarget -0.153326623515501 0.003656927634938 NA NA NA hsa-miR-429 MAP3K14 4.48815175680773 2.44117492218206e-17 -0.929542138683687 1.31735308419243e-05 miRNATAP -0.149133359352813 2.41419963094442e-16 NA NA NA hsa-miR-874-3p MAP3K14 1.95617235160298 2.0152613104032e-12 -0.929542138683687 1.31735308419243e-05 MirTarget -0.1737967270095 1.57895892349653e-06 NA NA NA hsa-miR-93-5p MAP3K14 3.03961860136032 1.11672209617395e-24 -0.929542138683687 1.31735308419243e-05 MirTarget -0.141287388297998 1.8190573493729e-05 NA NA NA hsa-let-7d-5p MAP3K2 1.33236798905207 1.1741085658466e-13 -0.461416176318694 0.0183069160365383 miRNATAP -0.304432029364471 2.31119655915906e-09 NA NA NA hsa-let-7g-3p MAP3K2 3.26398061402445 3.96263126107645e-25 -0.461416176318694 0.0183069160365383 miRNATAP -0.106502441499704 0.000238622404684433 NA NA NA hsa-let-7g-5p MAP3K2 1.20061455355116 1.50237505511483e-12 -0.461416176318694 0.0183069160365383 miRNATAP -0.284492513028896 1.752693936145e-07 NA NA NA hsa-miR-101-3p MAP3K2 0.522819989585461 0.00375627731618038 -0.461416176318694 0.0183069160365383 MirTarget -0.238800744160363 5.64551832737733e-06 NA NA NA hsa-miR-106b-5p MAP3K2 2.46782146831112 1.36171495805632e-23 -0.461416176318694 0.0183069160365383 MirTarget;miRNATAP -0.181743383956942 4.74182801305582e-07 NA NA NA hsa-miR-10b-5p MAP3K2 -0.155951595811628 0.555006386998027 -0.461416176318694 0.0183069160365383 miRNATAP -0.100219598413816 0.00538727822002406 NA NA NA hsa-miR-126-5p MAP3K2 0.895338176458417 2.33372756450713e-05 -0.461416176318694 0.0183069160365383 MirTarget -0.13266891909913 0.00298054700203414 NA NA NA hsa-miR-130b-5p MAP3K2 2.9963110846538 1.98883029416455e-18 -0.461416176318694 0.0183069160365383 mirMAP;miRNATAP -0.119609983914889 9.81792540412671e-06 NA NA NA hsa-miR-136-5p MAP3K2 2.09637138292451 1.50140005592201e-10 -0.461416176318694 0.0183069160365383 mirMAP -0.107573790955084 0.000135491247234798 NA NA NA hsa-miR-139-5p MAP3K2 -1.52606598644743 1.20474151350665e-08 -0.461416176318694 0.0183069160365383 miRanda;mirMAP -0.105360111178832 0.00248543801341473 NA NA NA hsa-miR-148b-5p MAP3K2 2.18024067300781 2.84770452413262e-14 -0.461416176318694 0.0183069160365383 mirMAP -0.155816578950761 3.59932709964038e-06 NA NA NA hsa-miR-17-5p MAP3K2 3.2710598467455 9.93128340539455e-27 -0.461416176318694 0.0183069160365383 MirTarget;TargetScan;miRNATAP -0.148586195507011 2.38128311467665e-07 NA NA NA hsa-miR-181a-5p MAP3K2 2.29556023480783 1.8138457900616e-21 -0.461416176318694 0.0183069160365383 mirMAP -0.138656769022448 0.000204891734034693 NA NA NA hsa-miR-181c-5p MAP3K2 1.58587920618301 1.57506918816933e-10 -0.461416176318694 0.0183069160365383 mirMAP -0.189021078301154 3.54230528779156e-07 NA NA NA hsa-miR-186-5p MAP3K2 1.47445398888668 3.0781726595413e-15 -0.461416176318694 0.0183069160365383 MirTarget;miRNATAP -0.241908074823309 7.9467681082853e-07 27498924 MicroRNA 186 suppresses cell proliferation and metastasis through targeting MAP3K2 in non small cell lung cancer; Furthermore we observed tthat the overexpression of MAP3K2 partially reversed the inhibitory effect of miR-186 on the proliferation and metastasis of A549 and HCC827 cell lines; Taken together our data indicated that miR-186 regulates lung cancer growth and metastasis through suppressing MAP3K2 expression at least partly metastasis lung squamous cell cancer hsa-miR-19a-3p MAP3K2 3.42309334186656 3.02671914353412e-28 -0.461416176318694 0.0183069160365383 MirTarget;mirMAP;miRNATAP -0.162225855161647 7.5323032520182e-09 NA NA NA hsa-miR-19b-3p MAP3K2 2.49529833021187 1.57028265846699e-23 -0.461416176318694 0.0183069160365383 MirTarget;mirMAP;miRNATAP -0.20691598951051 5.34415182587082e-09 NA NA NA hsa-miR-20a-5p MAP3K2 3.15577933619191 4.19753346442454e-25 -0.461416176318694 0.0183069160365383 MirTarget;miRNATAP -0.16826097936579 5.29308813947138e-09 NA NA NA hsa-miR-26a-2-3p MAP3K2 0.823520019989974 0.00017092160823769 -0.461416176318694 0.0183069160365383 mirMAP -0.137980256626112 0.00149423056366842 NA NA NA hsa-miR-26b-5p MAP3K2 0.885393662798425 3.2116297961629e-06 -0.461416176318694 0.0183069160365383 mirMAP;miRNATAP -0.156985010228015 0.00159969557710814 NA NA NA hsa-miR-28-5p MAP3K2 0.230152919654905 0.0742909586754846 -0.461416176318694 0.0183069160365383 miRanda -0.214332039714555 0.00466979679009669 NA NA NA hsa-miR-30b-5p MAP3K2 0.800822374912712 0.000133601914525413 -0.461416176318694 0.0183069160365383 mirMAP;miRNATAP -0.226731927302893 4.05476188280687e-07 NA NA NA hsa-miR-30c-5p MAP3K2 0.778774633108 0.000285599212429136 -0.461416176318694 0.0183069160365383 mirMAP;miRNATAP -0.301031008102674 2.97622740671034e-12 NA NA NA hsa-miR-30d-3p MAP3K2 0.977747550180601 4.3048212205381e-05 -0.461416176318694 0.0183069160365383 MirTarget -0.157216732721821 6.46641672557055e-05 NA NA NA hsa-miR-30d-5p MAP3K2 0.675423997639582 0.00270618816039773 -0.461416176318694 0.0183069160365383 mirMAP;miRNATAP -0.16326539405572 0.000100872779348169 NA NA NA hsa-miR-30e-5p MAP3K2 1.23904909539663 1.35561917122157e-09 -0.461416176318694 0.0183069160365383 mirMAP -0.255395478274143 1.55341284012735e-08 NA NA NA hsa-miR-320a MAP3K2 0.438165828017084 0.0390159073347133 -0.461416176318694 0.0183069160365383 miRanda;mirMAP -0.161476053306402 0.00031178761078448 NA NA NA hsa-miR-338-3p MAP3K2 0.453166438193782 0.144583389707558 -0.461416176318694 0.0183069160365383 miRNATAP -0.101871403344537 0.000825957460518608 NA NA NA hsa-miR-342-3p MAP3K2 1.49115144672245 1.43879249744621e-07 -0.461416176318694 0.0183069160365383 MirTarget;miRanda -0.137689892987922 2.69296195744114e-05 NA NA NA hsa-miR-34a-3p MAP3K2 1.75590866103657 8.02801510630657e-09 -0.461416176318694 0.0183069160365383 mirMAP -0.125323236814494 0.000218844943648558 NA NA NA hsa-miR-3913-5p MAP3K2 2.44353493655328 8.95279496632448e-15 -0.461416176318694 0.0183069160365383 miRNATAP -0.129961465572235 1.25457668900959e-05 NA NA NA hsa-miR-409-5p MAP3K2 1.56949123847358 5.91654175754272e-07 -0.461416176318694 0.0183069160365383 PITA -0.112889589253174 0.000328103094704494 NA NA NA hsa-miR-576-5p MAP3K2 2.20467023993664 3.4053475193793e-19 -0.461416176318694 0.0183069160365383 mirMAP -0.152475954139324 3.29568800400124e-05 NA NA NA hsa-miR-590-5p MAP3K2 3.18300989862077 2.06813568597893e-26 -0.461416176318694 0.0183069160365383 mirMAP -0.122845208169746 5.29723230714607e-05 NA NA NA hsa-miR-664a-3p MAP3K2 0.634721925861133 0.00520070178640421 -0.461416176318694 0.0183069160365383 mirMAP -0.201228098053755 1.19877670049176e-06 NA NA NA hsa-miR-93-5p MAP3K2 3.03961860136032 1.11672209617395e-24 -0.461416176318694 0.0183069160365383 MirTarget;miRNATAP -0.191368202581511 9.54384262850605e-11 NA NA NA hsa-let-7a-5p MAP3K3 0.618599506841644 2.76973453058748e-05 -0.867302315651695 4.69975718275905e-09 TargetScan;miRNATAP -0.26724561209896 6.18919027443841e-08 NA NA NA hsa-let-7b-5p MAP3K3 0.604314269683977 0.00140009936153214 -0.867302315651695 4.69975718275905e-09 miRNATAP -0.203475957483893 1.07260875312669e-07 NA NA NA hsa-let-7e-5p MAP3K3 0.860104282510173 6.04758298373779e-05 -0.867302315651695 4.69975718275905e-09 miRNATAP -0.193307311389442 7.37864461362761e-09 NA NA NA hsa-let-7f-5p MAP3K3 0.495648727272215 0.00355972741198794 -0.867302315651695 4.69975718275905e-09 miRNATAP -0.173464095265936 5.74246058544155e-05 NA NA NA hsa-let-7g-5p MAP3K3 1.20061455355116 1.50237505511483e-12 -0.867302315651695 4.69975718275905e-09 miRNATAP -0.359833220584565 8.44884738207879e-19 NA NA NA hsa-miR-106b-5p MAP3K3 2.46782146831112 1.36171495805632e-23 -0.867302315651695 4.69975718275905e-09 MirTarget;miRNATAP -0.292252262164011 6.88242631090465e-29 NA NA NA hsa-miR-107 MAP3K3 1.30977326593435 1.30372468603965e-11 -0.867302315651695 4.69975718275905e-09 PITA;miRanda;miRNATAP -0.325473046185407 4.21511962455708e-20 NA NA NA hsa-miR-141-3p MAP3K3 5.02396127982626 2.19224509139725e-24 -0.867302315651695 4.69975718275905e-09 miRNATAP -0.172869710454037 2.24127810311963e-43 NA NA NA hsa-miR-15a-5p MAP3K3 2.34669284378787 1.69544424500258e-23 -0.867302315651695 4.69975718275905e-09 MirTarget;miRNATAP -0.219612239690275 1.5228566528174e-14 NA NA NA hsa-miR-15b-5p MAP3K3 1.57112623124278 9.14247846750597e-13 -0.867302315651695 4.69975718275905e-09 MirTarget;miRNATAP -0.263811408563671 2.85413546917115e-17 NA NA NA hsa-miR-16-5p MAP3K3 1.75824877145857 1.68592440033108e-16 -0.867302315651695 4.69975718275905e-09 MirTarget;miRNATAP -0.224301757183537 3.94518248762126e-12 NA NA NA hsa-miR-17-5p MAP3K3 3.2710598467455 9.93128340539455e-27 -0.867302315651695 4.69975718275905e-09 MirTarget;TargetScan;miRNATAP -0.171611128780925 2.22614886704407e-15 NA NA NA hsa-miR-181a-5p MAP3K3 2.29556023480783 1.8138457900616e-21 -0.867302315651695 4.69975718275905e-09 MirTarget;miRNATAP -0.168464288336381 2.79957629707404e-09 NA NA NA hsa-miR-181b-5p MAP3K3 2.49307679431293 3.92829250217627e-20 -0.867302315651695 4.69975718275905e-09 MirTarget;miRNATAP -0.168561067534273 1.88740760503556e-11 NA NA NA hsa-miR-181c-5p MAP3K3 1.58587920618301 1.57506918816933e-10 -0.867302315651695 4.69975718275905e-09 MirTarget;miRNATAP -0.140503122259482 8.71150290649878e-07 NA NA NA hsa-miR-181d-5p MAP3K3 1.52204912185579 9.2693319057748e-08 -0.867302315651695 4.69975718275905e-09 MirTarget -0.135610473494314 5.26133028493809e-08 NA NA NA hsa-miR-182-5p MAP3K3 3.53923166221814 5.07781258121574e-21 -0.867302315651695 4.69975718275905e-09 miRNATAP -0.192247148692721 4.9074620442185e-29 NA NA NA hsa-miR-185-3p MAP3K3 2.3922478518806 1.3373426768452e-14 -0.867302315651695 4.69975718275905e-09 MirTarget -0.179661486614505 2.50800624598875e-16 NA NA NA hsa-miR-188-5p MAP3K3 2.52825126596644 6.78099435999778e-14 -0.867302315651695 4.69975718275905e-09 MirTarget;PITA;miRNATAP -0.113484223347038 2.6600591008806e-07 NA NA NA hsa-miR-193b-3p MAP3K3 2.25711804611899 4.1940744806631e-14 -0.867302315651695 4.69975718275905e-09 miRNAWalker2_validate;miRNATAP -0.120233120905124 2.70836986301579e-07 NA NA NA hsa-miR-194-5p MAP3K3 1.8992998339217 3.76507853301977e-10 -0.867302315651695 4.69975718275905e-09 miRNATAP -0.190921704069272 3.77942465212339e-17 NA NA NA hsa-miR-200a-3p MAP3K3 4.59434485520731 6.38952518573476e-18 -0.867302315651695 4.69975718275905e-09 miRNATAP -0.160800318099066 3.36580546873237e-42 NA NA NA hsa-miR-20a-5p MAP3K3 3.15577933619191 4.19753346442454e-25 -0.867302315651695 4.69975718275905e-09 MirTarget;miRNATAP -0.168195883644734 1.323867471843e-14 NA NA NA hsa-miR-2110 MAP3K3 1.16625590651194 6.4784195289885e-05 -0.867302315651695 4.69975718275905e-09 MirTarget -0.181255387444676 3.2386012789048e-12 NA NA NA hsa-miR-22-3p MAP3K3 1.21545661147757 1.61670170137775e-13 -0.867302315651695 4.69975718275905e-09 MirTarget;miRNATAP -0.125026120161726 0.00409501096109959 NA NA NA hsa-miR-23a-3p MAP3K3 1.00493340843378 2.55313889288924e-08 -0.867302315651695 4.69975718275905e-09 miRNATAP -0.13954802389965 0.000499995767713376 NA NA NA hsa-miR-23b-3p MAP3K3 -0.251132426825047 0.150200321210792 -0.867302315651695 4.69975718275905e-09 miRNATAP -0.113848808257563 0.00718050447286822 NA NA NA hsa-miR-28-5p MAP3K3 0.230152919654905 0.0742909586754846 -0.867302315651695 4.69975718275905e-09 MirTarget;PITA;miRanda;miRNATAP -0.210264267106694 0.000293317698661936 NA NA NA hsa-miR-29c-3p MAP3K3 -0.00968972577705429 0.97099586346872 -0.867302315651695 4.69975718275905e-09 mirMAP -0.151784580378555 2.04854239588177e-08 NA NA NA hsa-miR-330-3p MAP3K3 0.876747334239085 0.00073709016089703 -0.867302315651695 4.69975718275905e-09 mirMAP -0.217641560585133 8.93370339675348e-16 NA NA NA hsa-miR-331-3p MAP3K3 2.28379581858927 1.99663919173155e-18 -0.867302315651695 4.69975718275905e-09 mirMAP -0.26611512896316 6.31555082312646e-26 NA NA NA hsa-miR-33a-5p MAP3K3 3.79671563098419 1.15966309820345e-18 -0.867302315651695 4.69975718275905e-09 miRNATAP -0.160771736245397 9.09072759810643e-22 NA NA NA hsa-miR-423-5p MAP3K3 0.963563145758616 9.86109015204915e-07 -0.867302315651695 4.69975718275905e-09 PITA -0.317411273690967 2.74605197787487e-19 NA NA NA hsa-miR-429 MAP3K3 4.48815175680773 2.44117492218206e-17 -0.867302315651695 4.69975718275905e-09 miRNATAP -0.16431749982348 9.65750710740757e-44 NA NA NA hsa-miR-484 MAP3K3 1.81844463411787 1.82951571230938e-15 -0.867302315651695 4.69975718275905e-09 miRNATAP -0.300806816911617 6.87539891923824e-25 NA NA NA hsa-miR-505-3p MAP3K3 1.45322244209148 8.86597629645867e-10 -0.867302315651695 4.69975718275905e-09 miRNATAP -0.216568359354003 1.84178674843211e-13 NA NA NA hsa-miR-625-5p MAP3K3 1.42540152147292 1.95797147911206e-06 -0.867302315651695 4.69975718275905e-09 mirMAP -0.102788686820081 9.35514296646218e-05 NA NA NA hsa-miR-7-1-3p MAP3K3 1.84950311431067 1.25300363397654e-13 -0.867302315651695 4.69975718275905e-09 mirMAP -0.152412741279134 5.52336803591396e-08 NA NA NA hsa-miR-93-5p MAP3K3 3.03961860136032 1.11672209617395e-24 -0.867302315651695 4.69975718275905e-09 MirTarget;miRNATAP -0.224954459213565 9.74928657973139e-25 NA NA NA hsa-miR-96-5p MAP3K3 4.89433085814374 1.92000659886961e-31 -0.867302315651695 4.69975718275905e-09 MirTarget;TargetScan;miRNATAP -0.170021725288454 3.35899506427254e-28 NA NA NA hsa-miR-146b-5p MAP3K5 1.75587235896724 1.15724631266659e-07 -0.326146383467623 0.136909878119612 miRanda -0.170579105282158 4.2352802656353e-08 NA NA NA hsa-miR-199a-3p MAP3K5 0.640600337515787 0.0380326905134914 -0.326146383467623 0.136909878119612 PITA;miRNATAP -0.200960942189267 2.69788478393824e-09 NA NA NA hsa-miR-199a-5p MAP3K5 0.592984035153911 0.0674836634175293 -0.326146383467623 0.136909878119612 miRanda -0.12929375468602 7.07278456431251e-05 NA NA NA hsa-miR-199b-3p MAP3K5 0.643923492750702 0.0371742251925406 -0.326146383467623 0.136909878119612 PITA;miRNATAP -0.200769612876652 2.72260696854605e-09 NA NA NA hsa-miR-362-5p MAP3K6 1.59303749908759 9.582675908797e-08 -0.334985116569597 0.114600454695748 miRNATAP -0.171702996639165 3.06585199699914e-07 NA NA NA hsa-miR-592 MAP3K6 1.51765968871077 0.000636335248013204 -0.334985116569597 0.114600454695748 miRNATAP -0.141076903000968 8.31598045913215e-10 NA NA NA hsa-miR-92a-3p MAP3K6 2.06460102658973 1.44784291084757e-19 -0.334985116569597 0.114600454695748 miRNAWalker2_validate -0.15760778564572 0.000253193546088826 NA NA NA hsa-let-7a-3p MAP3K8 1.42015538786275 7.03375209382654e-13 -1.43093126329932 2.28044616882222e-08 MirTarget -0.240675318544026 0.000109636106602171 NA NA NA hsa-let-7g-3p MAP3K8 3.26398061402445 3.96263126107645e-25 -1.43093126329932 2.28044616882222e-08 MirTarget -0.120232623785086 0.00186435703214504 NA NA NA hsa-miR-106b-5p MAP3K8 2.46782146831112 1.36171495805632e-23 -1.43093126329932 2.28044616882222e-08 MirTarget;miRNATAP -0.14992622452974 0.00197254303801923 NA NA NA hsa-miR-128-3p MAP3K8 1.63756041666078 6.79626586407187e-14 -1.43093126329932 2.28044616882222e-08 MirTarget -0.208757620591552 0.000195572846241693 NA NA NA hsa-miR-17-5p MAP3K8 3.2710598467455 9.93128340539455e-27 -1.43093126329932 2.28044616882222e-08 miRNAWalker2_validate;MirTarget;TargetScan;miRNATAP -0.189373143109406 7.66688851383567e-07 NA NA NA hsa-miR-181a-5p MAP3K8 2.29556023480783 1.8138457900616e-21 -1.43093126329932 2.28044616882222e-08 MirTarget -0.162516771732996 0.00109320784662558 NA NA NA hsa-miR-181b-5p MAP3K8 2.49307679431293 3.92829250217627e-20 -1.43093126329932 2.28044616882222e-08 MirTarget -0.206644143407751 2.69216513871258e-06 NA NA NA hsa-miR-181c-5p MAP3K8 1.58587920618301 1.57506918816933e-10 -1.43093126329932 2.28044616882222e-08 MirTarget -0.131401994767643 0.00850427546462977 NA NA NA hsa-miR-181d-5p MAP3K8 1.52204912185579 9.2693319057748e-08 -1.43093126329932 2.28044616882222e-08 MirTarget -0.159085392847114 0.000257955115373206 NA NA NA hsa-miR-20a-5p MAP3K8 3.15577933619191 4.19753346442454e-25 -1.43093126329932 2.28044616882222e-08 MirTarget;miRNATAP -0.171865785330246 8.79487089089068e-06 NA NA NA hsa-miR-576-5p MAP3K8 2.20467023993664 3.4053475193793e-19 -1.43093126329932 2.28044616882222e-08 mirMAP -0.133745470179108 0.00649009111717066 NA NA NA hsa-miR-590-3p MAP3K8 2.59289455139753 1.03200520972022e-21 -1.43093126329932 2.28044616882222e-08 miRanda;mirMAP -0.153554611257788 0.000723487126692692 NA NA NA hsa-miR-590-5p MAP3K8 3.18300989862077 2.06813568597893e-26 -1.43093126329932 2.28044616882222e-08 PITA;miRanda -0.112483102697594 0.00563922578241451 NA NA NA hsa-miR-93-5p MAP3K8 3.03961860136032 1.11672209617395e-24 -1.43093126329932 2.28044616882222e-08 MirTarget;miRNATAP -0.138545821439185 0.000536121660489137 NA NA NA hsa-let-7a-2-3p MAP4K3 0.0400317820791161 0.91528727576685 0.275826390045942 0.153316320484152 MirTarget -0.14496874171326 5.05793708005272e-09 NA NA NA hsa-let-7c-5p MAP4K3 -2.07847142524506 5.51224567263294e-09 0.275826390045942 0.153316320484152 MirTarget -0.142244327084053 1.97891026159632e-08 23981581 MicroRNA let 7c inhibits migration and invasion of human non small cell lung cancer by targeting ITGB3 and MAP4K3; We then analyzed the potential targets of let-7c and found that ITGB3 and MAP4K3 were directly repressed by let-7c; Collectively our results suggest that let-7c by degrading ITGB3 and MAP4K3 prevents NSCLC metastasis metastasis lung squamous cell cancer hsa-let-7i-5p MAP4K3 0.412877696970403 0.00622731051981756 0.275826390045942 0.153316320484152 MirTarget;miRNATAP -0.391284379656709 2.44032046804112e-10 NA NA NA hsa-miR-142-3p MAP4K3 2.75247908790621 1.45636065474764e-12 0.275826390045942 0.153316320484152 miRanda;miRNATAP -0.156013130358579 7.61973746493151e-12 NA NA NA hsa-miR-155-5p MAP4K3 1.20164021433135 0.00086170622431261 0.275826390045942 0.153316320484152 MirTarget -0.228397657249775 1.55288401167598e-20 NA NA NA hsa-miR-199a-5p MAP4K3 0.592984035153911 0.0674836634175293 0.275826390045942 0.153316320484152 MirTarget;PITA;miRanda;miRNATAP -0.143617398946173 4.59924915300592e-07 NA NA NA hsa-miR-21-3p MAP4K3 2.19296355304364 4.63665722759779e-15 0.275826390045942 0.153316320484152 MirTarget -0.161447188706184 4.41030765682235e-07 NA NA NA hsa-miR-22-5p MAP4K3 1.88011544159252 1.63978222572222e-16 0.275826390045942 0.153316320484152 MirTarget -0.158414328114104 5.91676655898138e-05 NA NA NA hsa-miR-338-3p MAP4K3 0.453166438193782 0.144583389707558 0.275826390045942 0.153316320484152 MirTarget;PITA;miRanda -0.148357269972547 6.33147417310059e-07 NA NA NA hsa-miR-338-5p MAP4K3 -0.577691606146419 0.0472212680542825 0.275826390045942 0.153316320484152 PITA;mirMAP -0.155380788514006 1.2714283356826e-06 NA NA NA hsa-miR-340-5p MAP4K3 0.30282999308409 0.157744789519131 0.275826390045942 0.153316320484152 MirTarget -0.1562332612209 0.000357859221329456 NA NA NA hsa-miR-342-3p MAP4K3 1.49115144672245 1.43879249744621e-07 0.275826390045942 0.153316320484152 miRanda -0.192769510575037 1.64908310786901e-09 NA NA NA hsa-miR-374b-5p MAP4K3 0.0654362503857184 0.722673188879465 0.275826390045942 0.153316320484152 MirTarget;mirMAP;miRNATAP -0.138052223846382 0.00717799372729892 NA NA NA hsa-let-7d-5p MAP4K4 1.33236798905207 1.1741085658466e-13 0.130872521838526 0.522814141079271 MirTarget -0.198750067189594 0.00022699131054403 NA NA NA hsa-let-7e-5p MAP4K4 0.860104282510173 6.04758298373779e-05 0.130872521838526 0.522814141079271 MirTarget -0.119087580512201 0.00984403186595838 NA NA NA hsa-let-7f-5p MAP4K4 0.495648727272215 0.00355972741198794 0.130872521838526 0.522814141079271 MirTarget -0.292964362118374 4.93387794947104e-07 NA NA NA hsa-let-7g-5p MAP4K4 1.20061455355116 1.50237505511483e-12 0.130872521838526 0.522814141079271 MirTarget -0.439713732262393 2.99464463920395e-15 NA NA NA hsa-miR-10a-5p MAP4K4 1.15016989191194 0.00372037233992369 0.130872521838526 0.522814141079271 MirTarget -0.147822440715928 1.38217913768422e-09 NA NA NA hsa-miR-10b-5p MAP4K4 -0.155951595811628 0.555006386998027 0.130872521838526 0.522814141079271 MirTarget -0.186567135923217 5.38078541006639e-07 NA NA NA hsa-miR-1226-3p MAP4K4 1.38118928579963 0.000205503474787488 0.130872521838526 0.522814141079271 MirTarget -0.133768544746054 8.15532368306926e-06 NA NA NA hsa-miR-141-3p MAP4K4 5.02396127982626 2.19224509139725e-24 0.130872521838526 0.522814141079271 TargetScan -0.132557176493888 5.6923535135779e-13 24013097 To understand how miR-141 mediates the phenotype of pancreatic cancer cells a bioinformatics tool was used to identify MAP4K4 as a potential target of miR-141; The Dual-Luciferase reporter gene assay showed that miR-141 binds directly to the 3'-untranslated region 3'UTR of MAP4K4 to inhibit MAP4K4 expression; Western blot and quantitative real-time PCR qRT-PCR analyses revealed that MAP4K4 expression was inversely correlated with miR-141 expression both in pancreatic cancer samples and cell lines; In a nude mouse xenograft model both overexpression of miR-141 and knockdown of MAP4K4 significantly repressed pancreatic cancer cell growth; Therefore we conclude that miR-141 targets MAP4K4 acts as a tumor suppressor in pancreatic cancer cells and may serve as a novel therapeutic agent for miRNA-based pancreatic cancer therapy pancreatic cancer hsa-miR-148b-5p MAP4K4 2.18024067300781 2.84770452413262e-14 0.130872521838526 0.522814141079271 MirTarget -0.13216506501608 0.000178925982292735 NA NA NA hsa-miR-182-5p MAP4K4 3.53923166221814 5.07781258121574e-21 0.130872521838526 0.522814141079271 MirTarget -0.104709849442277 2.49586396666125e-05 NA NA NA hsa-miR-200b-3p MAP4K4 3.78235093249346 3.18343003239465e-14 0.130872521838526 0.522814141079271 TargetScan -0.150524412042051 4.50161990761318e-16 NA NA NA hsa-miR-23b-3p MAP4K4 -0.251132426825047 0.150200321210792 0.130872521838526 0.522814141079271 MirTarget;miRNATAP -0.237050684746564 3.39825283367143e-05 NA NA NA hsa-miR-29b-3p MAP4K4 1.65828197923813 1.02676780888141e-09 0.130872521838526 0.522814141079271 miRNATAP -0.152753836011035 1.7327794425752e-05 NA NA NA hsa-miR-29c-3p MAP4K4 -0.00968972577705429 0.97099586346872 0.130872521838526 0.522814141079271 miRNATAP -0.384526157305092 3.29921056086997e-28 NA NA NA hsa-miR-34a-5p MAP4K4 1.9016323452565 1.43092834643601e-14 0.130872521838526 0.522814141079271 MirTarget -0.259802212401119 8.07915118814483e-12 NA NA NA hsa-miR-361-5p MAP4K4 0.971859117235239 5.30236555707088e-09 0.130872521838526 0.522814141079271 miRanda -0.199103406325361 0.000758971606377554 NA NA NA hsa-miR-429 MAP4K4 4.48815175680773 2.44117492218206e-17 0.130872521838526 0.522814141079271 PITA;miRanda;miRNATAP -0.133654772417723 1.30714123303273e-14 NA NA NA hsa-miR-582-3p MAP4K4 0.00876844181512659 0.977126166214707 0.130872521838526 0.522814141079271 MirTarget -0.132192875191942 4.15168166148956e-05 NA NA NA hsa-miR-98-5p MAP4K4 1.11154309866014 1.24143909012085e-08 0.130872521838526 0.522814141079271 MirTarget -0.268019490076261 6.77902640815989e-08 NA NA NA hsa-miR-140-3p MAPK1 0.0608890720479334 0.727716871248724 -0.300413846088826 0.0202503240217449 PITA;miRNATAP -0.126850675206772 0.000457308593536618 NA NA NA hsa-miR-30c-5p MAPK1 0.778774633108 0.000285599212429136 -0.300413846088826 0.0202503240217449 mirMAP -0.161696427374548 1.83237959021178e-08 NA NA NA hsa-miR-30e-5p MAPK1 1.23904909539663 1.35561917122157e-09 -0.300413846088826 0.0202503240217449 mirMAP -0.123981973754552 3.68994437193015e-05 NA NA NA hsa-miR-34a-5p MAPK1 1.9016323452565 1.43092834643601e-14 -0.300413846088826 0.0202503240217449 mirMAP -0.113934200811126 2.89029232507908e-06 NA NA NA hsa-miR-130a-3p MAPK10 2.02021855058359 1.26427102520415e-11 -1.39613685607096 0.000971935890100464 miRNATAP -0.425271273370886 1.25010595009869e-10 NA NA NA hsa-miR-130b-3p MAPK10 3.5350292994509 1.73934183852569e-27 -1.39613685607096 0.000971935890100464 miRNATAP -0.157308872211673 0.00795632424961394 NA NA NA hsa-miR-146b-5p MAPK10 1.75587235896724 1.15724631266659e-07 -1.39613685607096 0.000971935890100464 miRanda -0.590131350156063 2.34286000506143e-24 NA NA NA hsa-miR-193a-3p MAPK10 1.60460546928078 2.86169793322984e-07 -1.39613685607096 0.000971935890100464 miRanda;miRNATAP -0.42329172270216 2.92418176925891e-11 NA NA NA hsa-miR-19a-3p MAPK10 3.42309334186656 3.02671914353412e-28 -1.39613685607096 0.000971935890100464 miRNATAP -0.250292411807473 4.93781898025515e-05 NA NA NA hsa-miR-19b-3p MAPK10 2.49529833021187 1.57028265846699e-23 -1.39613685607096 0.000971935890100464 miRNATAP -0.229843185806225 0.00332174049363652 NA NA NA hsa-miR-221-3p MAPK10 0.451556679024397 0.0909808299917811 -1.39613685607096 0.000971935890100464 miRNATAP -0.397173855876525 2.05290544452981e-07 NA NA NA hsa-miR-222-3p MAPK10 0.851783756239071 0.00266783568486918 -1.39613685607096 0.000971935890100464 miRNATAP -0.438283382047286 7.66762618038364e-10 NA NA NA hsa-miR-29a-3p MAPK10 -0.35074463683376 0.161238718982428 -1.39613685607096 0.000971935890100464 miRNATAP -0.454036231063091 2.56598108627441e-08 NA NA NA hsa-miR-454-3p MAPK10 2.47234127820054 1.12878018736016e-21 -1.39613685607096 0.000971935890100464 miRNATAP -0.209297634977375 0.00734798897159457 NA NA NA hsa-miR-455-5p MAPK10 2.2582442061694 1.43472128037398e-13 -1.39613685607096 0.000971935890100464 miRanda -0.32061697262034 7.65297587236286e-07 NA NA NA hsa-miR-590-3p MAPK10 2.59289455139753 1.03200520972022e-21 -1.39613685607096 0.000971935890100464 miRanda;mirMAP -0.317298220210079 1.7873353325919e-05 NA NA NA hsa-miR-590-5p MAPK10 3.18300989862077 2.06813568597893e-26 -1.39613685607096 0.000971935890100464 PITA;miRanda;miRNATAP -0.243164269697615 0.00024023443868175 NA NA NA hsa-let-7a-5p MAPK11 0.618599506841644 2.76973453058748e-05 -0.196415230656332 0.448327489263399 miRNAWalker2_validate -0.307003566466655 0.000342197753908208 NA NA NA hsa-miR-125a-5p MAPK12 0.599529391575274 0.0102300147180307 0.275993547616267 0.337663040254231 miRNATAP -0.20965473468004 0.000440693435433499 NA NA NA hsa-miR-125a-5p MAPK14 0.599529391575274 0.0102300147180307 -0.303640775567793 0.00978869421579312 PITA;miRanda;miRNATAP -0.124626568360645 2.34301936142697e-07 NA NA NA hsa-miR-128-3p MAPK14 1.63756041666078 6.79626586407187e-14 -0.303640775567793 0.00978869421579312 MirTarget -0.123697475515887 8.13597348141631e-07 NA NA NA hsa-miR-185-5p MAPK14 2.34016206907488 1.17481626642022e-26 -0.303640775567793 0.00978869421579312 miRNATAP -0.102052885005283 2.68112109007415e-05 NA NA NA hsa-miR-186-5p MAPK14 1.47445398888668 3.0781726595413e-15 -0.303640775567793 0.00978869421579312 mirMAP -0.145764601926808 6.78661707873898e-07 NA NA NA hsa-miR-320a MAPK14 0.438165828017084 0.0390159073347133 -0.303640775567793 0.00978869421579312 PITA;miRanda -0.141203542311255 1.09004547156543e-07 NA NA NA hsa-miR-361-5p MAPK14 0.971859117235239 5.30236555707088e-09 -0.303640775567793 0.00978869421579312 miRanda -0.12419245062687 0.000245845933637211 NA NA NA hsa-miR-125a-5p MAPK8 0.599529391575274 0.0102300147180307 -0.0756707943151755 0.760488436744535 miRNAWalker2_validate -0.204776391145867 6.53898244404679e-05 NA NA NA hsa-miR-195-3p MAPK8 -0.658653229922836 0.0142127125129199 -0.0756707943151755 0.760488436744535 mirMAP -0.125052773381987 0.00597119043582991 NA NA NA hsa-miR-30c-5p MAPK8 0.778774633108 0.000285599212429136 -0.0756707943151755 0.760488436744535 mirMAP -0.232507239110947 2.92068982830542e-05 NA NA NA hsa-miR-30e-5p MAPK8 1.23904909539663 1.35561917122157e-09 -0.0756707943151755 0.760488436744535 mirMAP -0.151898721585445 0.00886264348901288 NA NA NA hsa-miR-183-5p MAPK8IP1 4.19757025992371 4.79612296318304e-26 -1.24040596315331 5.44300964997354e-05 MirTarget;miRNATAP -0.118078537156352 0.000824760711314737 NA NA NA hsa-miR-24-3p MAPK8IP1 0.99989036772428 1.35595013650376e-07 -1.24040596315331 5.44300964997354e-05 MirTarget;miRNATAP -0.274027806786403 0.000487813792924133 NA NA NA hsa-miR-193a-3p MAPK8IP3 1.60460546928078 2.86169793322984e-07 0.354659217776788 0.141055880768316 miRanda -0.124721802893315 0.000679886889228232 NA NA NA hsa-miR-221-5p MAPK8IP3 -0.745357436702497 0.081887809839391 0.354659217776788 0.141055880768316 miRNATAP -0.188820738000543 3.25909404579727e-12 NA NA NA hsa-miR-766-3p MAPK8IP3 1.2456012547833 6.44584025471128e-06 0.354659217776788 0.141055880768316 mirMAP -0.201668936765515 1.1675214085758e-06 NA NA NA hsa-miR-361-5p MAPK9 0.971859117235239 5.30236555707088e-09 -0.269800666047329 0.00867453220223943 miRanda -0.122061441096387 3.51350695967922e-05 NA NA NA hsa-miR-125a-5p MAPKAPK2 0.599529391575274 0.0102300147180307 -0.224125552106657 0.0644502467861093 MirTarget;mirMAP -0.101734713265786 4.60987327357687e-05 NA NA NA hsa-miR-324-3p MAPKAPK2 2.08739139768981 3.11885987067952e-13 -0.224125552106657 0.0644502467861093 MirTarget -0.111754881090397 1.08981200782298e-08 NA NA NA hsa-miR-146b-3p MAPT 1.10569195233795 0.000660632782194023 -2.57854469569689 1.03709852332835e-08 miRNATAP -0.269220025751039 7.04672618702033e-05 NA NA NA hsa-miR-146b-5p MAPT 1.75587235896724 1.15724631266659e-07 -2.57854469569689 1.03709852332835e-08 PITA;miRNATAP -0.347355181117666 1.01741747020915e-07 NA NA NA hsa-miR-150-5p MAPT -0.105827294491332 0.799351458244375 -2.57854469569689 1.03709852332835e-08 mirMAP -0.179232639789578 0.000755019025486864 NA NA NA hsa-miR-17-3p MAPT 2.2704817679209 1.1667437320211e-22 -2.57854469569689 1.03709852332835e-08 mirMAP -0.248577237266801 0.00646130635492934 NA NA NA hsa-miR-181a-5p MAPT 2.29556023480783 1.8138457900616e-21 -2.57854469569689 1.03709852332835e-08 miRNATAP -0.523252068610867 1.38863402788777e-09 NA NA NA hsa-miR-181b-5p MAPT 2.49307679431293 3.92829250217627e-20 -2.57854469569689 1.03709852332835e-08 miRNATAP -0.465105925724328 1.50266587973775e-09 NA NA NA hsa-miR-2355-3p MAPT 1.2671753520641 5.70559238344897e-05 -2.57854469569689 1.03709852332835e-08 miRNATAP -0.336736435218348 2.42834898867295e-06 NA NA NA hsa-miR-24-3p MAPT 0.99989036772428 1.35595013650376e-07 -2.57854469569689 1.03709852332835e-08 mirMAP -0.838996987599714 1.4261287729144e-13 NA NA NA hsa-miR-27a-3p MAPT 1.66542180327138 4.93775737894805e-13 -2.57854469569689 1.03709852332835e-08 miRNATAP -0.926609198238851 1.6802019001214e-25 NA NA NA hsa-miR-27b-5p MAPT 0.393316367667332 0.051702301924024 -2.57854469569689 1.03709852332835e-08 mirMAP -0.377118190616119 0.000646560517078597 NA NA NA hsa-miR-29a-5p MAPT 1.46749674755271 3.34605004270294e-07 -2.57854469569689 1.03709852332835e-08 MirTarget;miRNATAP -0.548014398658762 3.60153288925154e-12 NA NA NA hsa-miR-31-5p MAPT 3.59165123035072 2.27423212057482e-07 -2.57854469569689 1.03709852332835e-08 mirMAP -0.183365570226388 2.56493480135665e-08 NA NA NA hsa-miR-320b MAPT 1.55692969039548 1.41071034251915e-08 -2.57854469569689 1.03709852332835e-08 miRanda -0.265238116522948 0.000855956944796598 NA NA NA hsa-miR-342-3p MAPT 1.49115144672245 1.43879249744621e-07 -2.57854469569689 1.03709852332835e-08 MirTarget;miRanda -0.244001231043647 0.00158548247752853 NA NA NA hsa-miR-34a-5p MAPT 1.9016323452565 1.43092834643601e-14 -2.57854469569689 1.03709852332835e-08 MirTarget;miRNATAP -0.387660765401499 7.71091072422528e-06 NA NA NA hsa-miR-34c-5p MAPT 2.07190852984647 7.35776320806257e-08 -2.57854469569689 1.03709852332835e-08 miRNAWalker2_validate;MirTarget;miRanda;miRNATAP -0.196985313395094 0.0011247026871084 23423488 Luciferase activity assay confirmed that the 3'-UTR of MAPT mRNA contains a functional miR-34c-5p binding site; Overexpression of miR-34c-5p significantly downregulated MAPT protein expression and increased the chemosensitivity of paclitaxel-resistant gastric cancer cells; DNA methylation dysregulation of miR-34c-5p and MAPT expression are critical factors in the chemoresistance of gastric cancer to paclitaxel drug resistance gastric cancer hsa-miR-362-3p MAPT 2.0756816987665 3.89026064579331e-12 -2.57854469569689 1.03709852332835e-08 MirTarget -0.204017235148501 0.00642520376795725 NA NA NA hsa-miR-484 MAPT 1.81844463411787 1.82951571230938e-15 -2.57854469569689 1.03709852332835e-08 mirMAP -0.245980604796571 0.00912144424691879 NA NA NA hsa-miR-582-3p MAPT 0.00876844181512659 0.977126166214707 -2.57854469569689 1.03709852332835e-08 PITA;miRNATAP -0.226463526870471 0.00184413564495213 NA NA NA hsa-miR-766-3p MAPT 1.2456012547833 6.44584025471128e-06 -2.57854469569689 1.03709852332835e-08 MirTarget -0.233174392869908 0.00345805701492362 NA NA NA hsa-miR-874-3p MAPT 1.95617235160298 2.0152613104032e-12 -2.57854469569689 1.03709852332835e-08 MirTarget -0.348140480152003 6.66343265454813e-06 NA NA NA hsa-miR-944 MAPT 2.91186649218281 1.31574753528144e-06 -2.57854469569689 1.03709852332835e-08 mirMAP -0.260852678135799 1.02400529811885e-12 NA NA NA hsa-miR-96-5p MAPT 4.89433085814374 1.92000659886961e-31 -2.57854469569689 1.03709852332835e-08 mirMAP -0.137767116789319 0.00615899410928196 NA NA NA hsa-miR-28-5p MAX 0.230152919654905 0.0742909586754846 -0.300810607733172 0.00220412918683644 miRanda -0.121010016036467 0.00138402325810049 NA NA NA hsa-let-7a-3p MEF2C 1.42015538786275 7.03375209382654e-13 -2.13436808535659 1.07833769123274e-14 MirTarget;miRNATAP -0.456270819893371 9.72465081371634e-12 NA NA NA hsa-let-7a-5p MEF2C 0.618599506841644 2.76973453058748e-05 -2.13436808535659 1.07833769123274e-14 TargetScan;miRNATAP -0.5234421287863 2.23312387878142e-08 NA NA NA hsa-let-7b-3p MEF2C 0.868207752019623 1.30460056774366e-05 -2.13436808535659 1.07833769123274e-14 MirTarget;miRNATAP -0.316844333440093 4.16607759485225e-06 NA NA NA hsa-let-7b-5p MEF2C 0.604314269683977 0.00140009936153214 -2.13436808535659 1.07833769123274e-14 miRNAWalker2_validate;miRNATAP -0.414181911605398 1.10373371445485e-08 NA NA NA hsa-let-7e-5p MEF2C 0.860104282510173 6.04758298373779e-05 -2.13436808535659 1.07833769123274e-14 miRNATAP -0.289013976085589 6.17805595658533e-06 NA NA NA hsa-let-7f-1-3p MEF2C 1.55054488387679 7.31326775537952e-11 -2.13436808535659 1.07833769123274e-14 MirTarget -0.266673834549629 4.61590308899395e-06 NA NA NA hsa-let-7f-5p MEF2C 0.495648727272215 0.00355972741198794 -2.13436808535659 1.07833769123274e-14 miRNATAP -0.247167885372456 0.00263223329061998 NA NA NA hsa-let-7g-5p MEF2C 1.20061455355116 1.50237505511483e-12 -2.13436808535659 1.07833769123274e-14 miRNATAP -0.553031058329655 1.76527598007424e-12 NA NA NA hsa-miR-103a-2-5p MEF2C 2.47599305985086 7.933028987326e-11 -2.13436808535659 1.07833769123274e-14 MirTarget -0.314529303870119 5.09232562133424e-16 NA NA NA hsa-miR-107 MEF2C 1.30977326593435 1.30372468603965e-11 -2.13436808535659 1.07833769123274e-14 miRanda -0.533309905550351 5.17272495930481e-15 NA NA NA hsa-miR-125a-3p MEF2C 1.24490295132072 5.26925231010328e-06 -2.13436808535659 1.07833769123274e-14 MirTarget;PITA;miRanda -0.228422585099096 4.52403420580576e-06 NA NA NA hsa-miR-1296-5p MEF2C 1.20556568733873 8.93601534401924e-06 -2.13436808535659 1.07833769123274e-14 MirTarget -0.298906118198994 1.80670588298551e-09 NA NA NA hsa-miR-130b-5p MEF2C 2.9963110846538 1.98883029416455e-18 -2.13436808535659 1.07833769123274e-14 MirTarget;miRNATAP -0.385111662250087 1.16279385730019e-24 NA NA NA hsa-miR-135b-5p MEF2C 3.62510365056501 1.09148980810091e-10 -2.13436808535659 1.07833769123274e-14 MirTarget -0.180815149379872 2.81146361223425e-13 NA NA NA hsa-miR-182-5p MEF2C 3.53923166221814 5.07781258121574e-21 -2.13436808535659 1.07833769123274e-14 MirTarget;miRNATAP -0.364343251860128 6.0726616709347e-29 NA NA NA hsa-miR-183-5p MEF2C 4.19757025992371 4.79612296318304e-26 -2.13436808535659 1.07833769123274e-14 MirTarget;miRNATAP -0.366772331401485 2.92162029797906e-34 NA NA NA hsa-miR-186-5p MEF2C 1.47445398888668 3.0781726595413e-15 -2.13436808535659 1.07833769123274e-14 miRNATAP -0.57179653374938 2.40383841050251e-16 NA NA NA hsa-miR-188-5p MEF2C 2.52825126596644 6.78099435999778e-14 -2.13436808535659 1.07833769123274e-14 MirTarget;PITA -0.292360284944456 1.41621052256493e-12 NA NA NA hsa-miR-18a-3p MEF2C 2.14813400940323 2.23460809936028e-06 -2.13436808535659 1.07833769123274e-14 MirTarget;miRNATAP -0.271568729087656 2.08364883465035e-13 NA NA NA hsa-miR-18a-5p MEF2C 3.78535678765353 3.72446596213886e-26 -2.13436808535659 1.07833769123274e-14 MirTarget -0.32753184721059 5.0041292600236e-19 NA NA NA hsa-miR-194-5p MEF2C 1.8992998339217 3.76507853301977e-10 -2.13436808535659 1.07833769123274e-14 miRNATAP -0.286415328426924 5.8412897687808e-11 NA NA NA hsa-miR-19a-3p MEF2C 3.42309334186656 3.02671914353412e-28 -2.13436808535659 1.07833769123274e-14 miRNATAP -0.388037041193279 8.70704028468689e-23 NA NA NA hsa-miR-19b-3p MEF2C 2.49529833021187 1.57028265846699e-23 -2.13436808535659 1.07833769123274e-14 miRNATAP -0.517491629210605 1.52152308001336e-25 NA NA NA hsa-miR-200c-5p MEF2C 2.95761105443819 3.11105707262802e-11 -2.13436808535659 1.07833769123274e-14 MirTarget -0.399158758331012 4.6703090597844e-43 NA NA NA hsa-miR-203a-3p MEF2C 3.12352008343999 9.49391438647189e-07 -2.13436808535659 1.07833769123274e-14 MirTarget -0.186497961293881 6.50003682267059e-20 NA NA NA hsa-miR-21-5p MEF2C 2.73773305747971 1.38864982139576e-43 -2.13436808535659 1.07833769123274e-14 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.349224895568138 2.20173424114234e-08 NA NA NA hsa-miR-224-3p MEF2C 1.87536386559317 6.15140969394846e-05 -2.13436808535659 1.07833769123274e-14 MirTarget;mirMAP -0.184969473076766 7.80600181379277e-10 NA NA NA hsa-miR-2355-5p MEF2C 1.32510310704724 8.25139516692683e-07 -2.13436808535659 1.07833769123274e-14 MirTarget -0.158565472059937 0.00181527876663172 NA NA NA hsa-miR-23a-3p MEF2C 1.00493340843378 2.55313889288924e-08 -2.13436808535659 1.07833769123274e-14 MirTarget;miRNATAP -0.566571138334224 1.99511788596001e-14 NA NA NA hsa-miR-26b-5p MEF2C 0.885393662798425 3.2116297961629e-06 -2.13436808535659 1.07833769123274e-14 miRNAWalker2_validate;miRNATAP -0.473806729217027 2.70501621357962e-11 NA NA NA hsa-miR-27a-3p MEF2C 1.66542180327138 4.93775737894805e-13 -2.13436808535659 1.07833769123274e-14 miRNATAP -0.407740195375108 9.41346876092027e-13 NA NA NA hsa-miR-27b-3p MEF2C 0.196007704287769 0.295630157035388 -2.13436808535659 1.07833769123274e-14 miRNATAP -0.237786374937992 0.00142852292617996 NA NA NA hsa-miR-3065-5p MEF2C 2.74629919868982 1.86846589298284e-08 -2.13436808535659 1.07833769123274e-14 MirTarget;mirMAP -0.243615651513731 1.97947910914591e-13 NA NA NA hsa-miR-30d-3p MEF2C 0.977747550180601 4.3048212205381e-05 -2.13436808535659 1.07833769123274e-14 MirTarget;miRNATAP -0.33036226968269 6.0789906420311e-09 NA NA NA hsa-miR-32-3p MEF2C 2.02436999565685 5.94091197945307e-09 -2.13436808535659 1.07833769123274e-14 mirMAP -0.299150975663722 5.99195973268478e-12 NA NA NA hsa-miR-320a MEF2C 0.438165828017084 0.0390159073347133 -2.13436808535659 1.07833769123274e-14 miRanda -0.246858002294213 0.000156472805396268 NA NA NA hsa-miR-320b MEF2C 1.55692969039548 1.41071034251915e-08 -2.13436808535659 1.07833769123274e-14 miRanda -0.385899526385525 8.74872987099461e-16 NA NA NA hsa-miR-324-3p MEF2C 2.08739139768981 3.11885987067952e-13 -2.13436808535659 1.07833769123274e-14 miRNATAP -0.466588941305981 4.79399309627887e-26 NA NA NA hsa-miR-330-3p MEF2C 0.876747334239085 0.00073709016089703 -2.13436808535659 1.07833769123274e-14 MirTarget;PITA;miRNATAP -0.336537651930933 1.01622058233661e-10 NA NA NA hsa-miR-331-5p MEF2C 2.17414714166315 1.54547681391888e-18 -2.13436808535659 1.07833769123274e-14 PITA -0.532390529993853 1.96388747914755e-24 NA NA NA hsa-miR-335-3p MEF2C 3.08791651139852 5.31309869723517e-12 -2.13436808535659 1.07833769123274e-14 MirTarget;mirMAP -0.193189694376631 4.83768631067688e-11 NA NA NA hsa-miR-33a-3p MEF2C 1.72765312072219 1.51784443453521e-07 -2.13436808535659 1.07833769123274e-14 MirTarget;mirMAP;miRNATAP -0.316851615472401 9.46883249069393e-13 NA NA NA hsa-miR-34c-3p MEF2C 2.41359195938096 3.46966584087088e-10 -2.13436808535659 1.07833769123274e-14 miRNATAP -0.129018431719358 0.000383791003170081 NA NA NA hsa-miR-3613-5p MEF2C 2.64358387329263 1.0373753017245e-24 -2.13436808535659 1.07833769123274e-14 MirTarget;miRNATAP -0.443515091077908 7.51605429695137e-19 NA NA NA hsa-miR-362-3p MEF2C 2.0756816987665 3.89026064579331e-12 -2.13436808535659 1.07833769123274e-14 MirTarget;miRNATAP -0.226871201615162 8.71827950533544e-07 NA NA NA hsa-miR-421 MEF2C 1.17791565395543 6.78526676976629e-06 -2.13436808535659 1.07833769123274e-14 PITA;miRanda;miRNATAP -0.292034095414821 1.73895708128044e-08 NA NA NA hsa-miR-425-5p MEF2C 3.07071373939774 4.02947460586085e-25 -2.13436808535659 1.07833769123274e-14 MirTarget;miRNATAP -0.414268036414958 2.66045895838954e-23 NA NA NA hsa-miR-429 MEF2C 4.48815175680773 2.44117492218206e-17 -2.13436808535659 1.07833769123274e-14 miRanda;miRNATAP -0.280879258963218 3.37208411035422e-34 NA NA NA hsa-miR-450b-5p MEF2C 1.69244418548325 1.68064054148881e-10 -2.13436808535659 1.07833769123274e-14 MirTarget;PITA;miRNATAP -0.178000280414794 0.000486005354423729 NA NA NA hsa-miR-452-5p MEF2C 1.37180058737183 0.00171494843537772 -2.13436808535659 1.07833769123274e-14 MirTarget;miRNATAP -0.131935407930639 2.34433143741073e-05 NA NA NA hsa-miR-501-5p MEF2C 1.93654809410041 1.3779381780759e-10 -2.13436808535659 1.07833769123274e-14 MirTarget;PITA;miRNATAP -0.30614644859885 1.20385959819436e-11 NA NA NA hsa-miR-550a-3p MEF2C 1.78308792532884 2.47673569057582e-07 -2.13436808535659 1.07833769123274e-14 MirTarget -0.251169581269115 1.21508874382851e-08 NA NA NA hsa-miR-590-3p MEF2C 2.59289455139753 1.03200520972022e-21 -2.13436808535659 1.07833769123274e-14 mirMAP -0.409022278037662 1.78038855545118e-17 NA NA NA hsa-miR-590-5p MEF2C 3.18300989862077 2.06813568597893e-26 -2.13436808535659 1.07833769123274e-14 MirTarget;PITA;miRanda;miRNATAP -0.427390087188316 3.94248317603339e-24 NA NA NA hsa-miR-7-1-3p MEF2C 1.84950311431067 1.25300363397654e-13 -2.13436808535659 1.07833769123274e-14 MirTarget;mirMAP -0.37614371689288 8.34528664222258e-13 NA NA NA hsa-miR-744-3p MEF2C 2.7517405670917 4.22040908411227e-14 -2.13436808535659 1.07833769123274e-14 MirTarget;miRNATAP -0.372239155094599 3.60537280520191e-27 NA NA NA hsa-miR-92a-3p MEF2C 2.06460102658973 1.44784291084757e-19 -2.13436808535659 1.07833769123274e-14 miRNAWalker2_validate -0.604855822797725 1.02342466200202e-28 NA NA NA hsa-miR-940 MEF2C 3.21011374578759 2.7923171128495e-14 -2.13436808535659 1.07833769123274e-14 PITA;miRNATAP -0.30422536293461 3.57998581036699e-20 NA NA NA hsa-miR-944 MEF2C 2.91186649218281 1.31574753528144e-06 -2.13436808535659 1.07833769123274e-14 mirMAP -0.223297332816327 5.65903433378841e-24 NA NA NA hsa-miR-96-5p MEF2C 4.89433085814374 1.92000659886961e-31 -2.13436808535659 1.07833769123274e-14 miRNATAP -0.361919122234323 1.73921049453885e-36 NA NA NA hsa-miR-125b-5p MKNK2 -1.16462950151259 0.000288900271798384 -0.00870530165369132 0.959744888779092 miRNAWalker2_validate;MirTarget -0.149975714389938 3.23501736210473e-09 NA NA NA hsa-miR-214-5p MKNK2 0.962365243662358 0.0069147776948866 -0.00870530165369132 0.959744888779092 MirTarget -0.130118075865085 1.40634574805351e-08 NA NA NA hsa-miR-370-3p MKNK2 0.342556854360961 0.289563705563924 -0.00870530165369132 0.959744888779092 MirTarget -0.117423840908683 8.98149579919249e-06 NA NA NA hsa-miR-495-3p MKNK2 -0.0847115949846082 0.763475496144456 -0.00870530165369132 0.959744888779092 MirTarget -0.100642270393116 0.000693867618634643 NA NA NA hsa-let-7a-5p MRAS 0.618599506841644 2.76973453058748e-05 -1.30047814978706 1.21141012267765e-05 mirMAP -0.737681667973198 2.65059909084462e-14 NA NA NA hsa-let-7b-5p MRAS 0.604314269683977 0.00140009936153214 -1.30047814978706 1.21141012267765e-05 mirMAP -0.421401696370699 3.34272798505785e-08 NA NA NA hsa-let-7e-5p MRAS 0.860104282510173 6.04758298373779e-05 -1.30047814978706 1.21141012267765e-05 mirMAP -0.309417830323945 4.12675966259557e-06 NA NA NA hsa-let-7f-5p MRAS 0.495648727272215 0.00355972741198794 -1.30047814978706 1.21141012267765e-05 mirMAP -0.408058271047108 1.92710243502986e-06 NA NA NA hsa-let-7g-5p MRAS 1.20061455355116 1.50237505511483e-12 -1.30047814978706 1.21141012267765e-05 mirMAP -0.599701377167044 3.15678660013671e-13 NA NA NA hsa-miR-103a-2-5p MRAS 2.47599305985086 7.933028987326e-11 -1.30047814978706 1.21141012267765e-05 mirMAP -0.25217082871927 1.19283853976295e-09 NA NA NA hsa-miR-130b-5p MRAS 2.9963110846538 1.98883029416455e-18 -1.30047814978706 1.21141012267765e-05 mirMAP -0.289897227649461 1.13137652927431e-12 NA NA NA hsa-miR-135b-5p MRAS 3.62510365056501 1.09148980810091e-10 -1.30047814978706 1.21141012267765e-05 miRNATAP -0.180245710762348 5.14985019200415e-12 NA NA NA hsa-miR-15a-5p MRAS 2.34669284378787 1.69544424500258e-23 -1.30047814978706 1.21141012267765e-05 miRNATAP -0.45980337367306 5.76913835322092e-16 NA NA NA hsa-miR-15b-5p MRAS 1.57112623124278 9.14247846750597e-13 -1.30047814978706 1.21141012267765e-05 miRNATAP -0.434429767439064 6.05126114923253e-12 NA NA NA hsa-miR-16-5p MRAS 1.75824877145857 1.68592440033108e-16 -1.30047814978706 1.21141012267765e-05 miRNATAP -0.454395779907281 1.77488308069132e-12 NA NA NA hsa-miR-182-5p MRAS 3.53923166221814 5.07781258121574e-21 -1.30047814978706 1.21141012267765e-05 miRNATAP -0.350262585535789 7.07903170837591e-24 NA NA NA hsa-miR-26b-5p MRAS 0.885393662798425 3.2116297961629e-06 -1.30047814978706 1.21141012267765e-05 miRNATAP -0.584244090580643 2.90430804252354e-15 NA NA NA hsa-miR-29b-3p MRAS 1.65828197923813 1.02676780888141e-09 -1.30047814978706 1.21141012267765e-05 mirMAP -0.303920389894105 4.23528221680215e-09 NA NA NA hsa-miR-29c-3p MRAS -0.00968972577705429 0.97099586346872 -1.30047814978706 1.21141012267765e-05 mirMAP -0.287995222844604 1.02353082231546e-07 NA NA NA hsa-miR-3065-3p MRAS 2.16221780121195 9.65525739884541e-09 -1.30047814978706 1.21141012267765e-05 miRNATAP -0.148546650601488 7.9750551259462e-05 NA NA NA hsa-miR-3065-5p MRAS 2.74629919868982 1.86846589298284e-08 -1.30047814978706 1.21141012267765e-05 mirMAP -0.118166519830265 0.000944780125505612 NA NA NA hsa-miR-30d-3p MRAS 0.977747550180601 4.3048212205381e-05 -1.30047814978706 1.21141012267765e-05 mirMAP -0.526035636041477 1.35954231297635e-19 NA NA NA hsa-miR-30e-3p MRAS -0.215663037684509 0.235375122783546 -1.30047814978706 1.21141012267765e-05 mirMAP -0.428667444839994 8.53486300853544e-08 NA NA NA hsa-miR-32-3p MRAS 2.02436999565685 5.94091197945307e-09 -1.30047814978706 1.21141012267765e-05 mirMAP -0.256609855895682 2.70603187488454e-08 NA NA NA hsa-miR-324-5p MRAS 2.95683728155095 1.32960514360912e-20 -1.30047814978706 1.21141012267765e-05 miRanda -0.27549030650863 1.12663330164637e-10 NA NA NA hsa-miR-330-5p MRAS 1.15100069700871 4.85551805046014e-07 -1.30047814978706 1.21141012267765e-05 miRanda -0.27628519059916 1.02211579014909e-05 NA NA NA hsa-miR-335-3p MRAS 3.08791651139852 5.31309869723517e-12 -1.30047814978706 1.21141012267765e-05 mirMAP -0.186397976666785 1.86081571959519e-09 NA NA NA hsa-miR-33a-3p MRAS 1.72765312072219 1.51784443453521e-07 -1.30047814978706 1.21141012267765e-05 mirMAP -0.365378725110188 3.28248890077898e-15 NA NA NA hsa-miR-423-5p MRAS 0.963563145758616 9.86109015204915e-07 -1.30047814978706 1.21141012267765e-05 miRNATAP -0.542171663981532 3.35780208769606e-14 NA NA NA hsa-miR-429 MRAS 4.48815175680773 2.44117492218206e-17 -1.30047814978706 1.21141012267765e-05 miRanda;miRNATAP -0.305396439739903 6.04252534633424e-37 NA NA NA hsa-miR-582-5p MRAS 0.609226359812689 0.032988717891497 -1.30047814978706 1.21141012267765e-05 mirMAP -0.337091970550026 1.25452329198951e-11 NA NA NA hsa-miR-652-3p MRAS 2.16948080686801 4.80670949499399e-18 -1.30047814978706 1.21141012267765e-05 miRNAWalker2_validate -0.42170915650208 6.48104470006076e-15 NA NA NA hsa-miR-7-1-3p MRAS 1.84950311431067 1.25300363397654e-13 -1.30047814978706 1.21141012267765e-05 mirMAP -0.298257826702854 1.00988026513502e-07 NA NA NA hsa-miR-96-5p MRAS 4.89433085814374 1.92000659886961e-31 -1.30047814978706 1.21141012267765e-05 TargetScan;miRNATAP -0.302216752307352 4.73723387400993e-22 NA NA NA hsa-miR-98-5p MRAS 1.11154309866014 1.24143909012085e-08 -1.30047814978706 1.21141012267765e-05 mirMAP -0.423067513772563 6.05526058843975e-09 NA NA NA hsa-let-7f-5p MYC 0.495648727272215 0.00355972741198794 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.302610362502413 0.00593577090066522 NA NA NA hsa-let-7g-5p MYC 1.20061455355116 1.50237505511483e-12 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate;miRTarBase -0.647634835001101 8.67569135821405e-10 NA NA NA hsa-miR-320a MYC 0.438165828017084 0.0390159073347133 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.270203083250914 0.00203008366284758 25736597 Furthermore progesterone P4 promoted the expression of miR-320a by repressing c-Myc expression while estrogen E2 exerted the opposite effect breast cancer hsa-miR-320b MYC 1.55692969039548 1.41071034251915e-08 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.211227042104883 0.00142753396089349 26487644 miR 320b suppresses cell proliferation by targeting c Myc in human colorectal cancer cells; Overexpression of miR-320b in CRC cells was statistically correlated with a decrease of cell growth in vitro and in vivo while c-MYC was identified as a target gene of miR-320b in CRC; Furthermore it was found that up-regulation of c-Myc can attenuate the effects induced by miR-320b; Our identification of c-MYC as a target gene of miR-320b provides new insights into the pathophysiology of CRC proliferation and identifies miR-320b as a novel therapeutic target for the treatment of CRC colorectal cancer hsa-miR-335-5p MYC 1.77247705492746 2.22457658872091e-06 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.15527675337735 0.00141118517916367 NA NA NA hsa-miR-34a-5p MYC 1.9016323452565 1.43092834643601e-14 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate;miRTarBase -0.359767953473847 5.62932761832786e-07 25572695;25686834;21460242;22159222;23640973;22830357;22235332 The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;miR 34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c Myc pathway;Myc mediated repression of microRNA 34a promotes high grade transformation of B cell lymphoma by dysregulation of FoxP1;MicroRNA 34a suppresses malignant transformation by targeting c Myc transcriptional complexes in human renal cell carcinoma; We investigated the functional effects of microRNA-34a miR-34a on c-Myc transcriptional complexes in renal cell carcinoma; miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region which was revealed by luciferase reporter assays; Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription indicating a novel role of miR-34a in the regulation of transcription by c-Myc;Among them miR-34a was also associated with poor prognosis in 2 independent series of leukemic and nodal MCL and in cooperation with high expression of the MYC oncogene;We report that miR-34a did not inhibit cell proliferation notwithstanding a marked down-regulation of c-MYC;MicroRNA 34a modulates c Myc transcriptional complexes to suppress malignancy in human prostate cancer cells; We studied the functional effects of miR-34a on c-Myc transcriptional complexes in PC-3 prostate cancer cells; miR-34a downregulated expression of c-Myc oncogene by targeting its 3' UTR as shown by luciferase reporter assays; This is the first report to document that miR-34a suppresses assembly and function of the c-Myc-Skp2-Miz1 complex that activates RhoA and the c-Myc-pTEFB complex that elongates transcription of various genes suggesting a novel role of miR-34a in the regulation of transcription by c-Myc complex ;;;malignant trasformation;worse prognosis;; bladder cancer;liver cancer;B cell lymphoma;kidney renal cell cancer;lymphoma;lymphoma;prostate cancer hsa-miR-423-5p MYC 0.963563145758616 9.86109015204915e-07 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.592117097378242 1.10389937335588e-10 NA NA NA hsa-miR-429 MYC 4.48815175680773 2.44117492218206e-17 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.269400502460394 6.09134482841112e-17 21684154;24633485 miR 429 modulates the expression of c myc in human gastric carcinoma cells; SGC-7901 gastric cancer cells were transfected with miR-429 mimics and endogenous c-myc expression was detected by western blots; We performed functional assays using the 3'UTR of the c-myc gene as a miR-429 target in a luciferase reporter assay system; miR-429 significantly downregulated endogenous c-myc expression in SGC-7901 cells; Action of miR/429 on c-myc 3'UTR was confirmed; c-myc is an important miR-429 target gene;It is known that miR-429 is down-regulated and functions as a tumor suppressor by targeting c-myc and PLGG1 in gastric and breast cancer ; gastric cancer;sarcoma hsa-miR-744-5p MYC 1.48254348878737 3.23019501613577e-09 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.254793177391621 0.000439915184612437 24991193 Decrease expression of microRNA 744 promotes cell proliferation by targeting c Myc in human hepatocellular carcinoma; Quantitative reverse-transcription polymerase chain reaction qRT-PCR was conducted to detect the expression of miR-744 and Immunohistochemistry was performed to detect expression of c-Myc in HCC specimens and adjacent normal tissues; Luciferase reporter assays was performed to confirm whether miR-744 regulated the expression of c-Myc; Luciferase assay and Western blot analysis revealed that c-Myc is a direct target of miR-744; Down-regulation of miR-744 and up-regulation of c-Myc were detected in HCC specimens compared with adjacent normal tissues; Moreover restoration of miR-744 rescues c-Myc induced HCC proliferation; Our data suggest that miR-744 exerts its tumor suppressor function by targeting c-Myc leading to the inhibition of HCC cell growth liver cancer hsa-miR-98-5p MYC 1.11154309866014 1.24143909012085e-08 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate;miRTarBase -0.602921793997467 5.7325871539819e-11 NA NA NA hsa-miR-139-5p NF1 -1.52606598644743 1.20474151350665e-08 0.0732194429255477 0.645307074955048 miRanda -0.110526489258454 8.37834467200425e-05 NA NA NA hsa-miR-146b-5p NF1 1.75587235896724 1.15724631266659e-07 0.0732194429255477 0.645307074955048 miRanda -0.127547138294409 1.4081291682613e-08 NA NA NA hsa-miR-29a-5p NF1 1.46749674755271 3.34605004270294e-07 0.0732194429255477 0.645307074955048 MirTarget;miRNATAP -0.129236767489049 2.95778906260816e-06 NA NA NA hsa-miR-30a-5p NF1 -0.878357906436456 0.000509952992366057 0.0732194429255477 0.645307074955048 MirTarget;mirMAP;miRNATAP -0.122903163063386 4.5532399319875e-05 NA NA NA hsa-miR-362-3p NF1 2.0756816987665 3.89026064579331e-12 0.0732194429255477 0.645307074955048 miRanda -0.121933419104743 1.95266011585564e-06 NA NA NA hsa-miR-130b-5p NFATC2 2.9963110846538 1.98883029416455e-18 -2.09940213646525 2.77134949511158e-05 MirTarget -0.272734196833187 9.99532798497572e-05 NA NA NA hsa-miR-16-2-3p NFATC2 2.31623086727196 4.29838149388188e-20 -2.09940213646525 2.77134949511158e-05 mirMAP -0.346662368458709 0.000179256594294205 NA NA NA hsa-miR-182-5p NFATC2 3.53923166221814 5.07781258121574e-21 -2.09940213646525 2.77134949511158e-05 mirMAP -0.274974364845855 7.50815876894642e-06 NA NA NA hsa-miR-185-5p NFATC2 2.34016206907488 1.17481626642022e-26 -2.09940213646525 2.77134949511158e-05 MirTarget -0.377810783509097 0.000327278994012812 NA NA NA hsa-miR-186-5p NFATC2 1.47445398888668 3.0781726595413e-15 -2.09940213646525 2.77134949511158e-05 mirMAP -0.437555927141547 0.000604504699648039 NA NA NA hsa-miR-19a-3p NFATC2 3.42309334186656 3.02671914353412e-28 -2.09940213646525 2.77134949511158e-05 mirMAP -0.373437340706404 2.96351119749213e-07 NA NA NA hsa-miR-19b-3p NFATC2 2.49529833021187 1.57028265846699e-23 -2.09940213646525 2.77134949511158e-05 mirMAP -0.469765074696736 3.34509012953115e-07 NA NA NA hsa-miR-200b-5p NFATC2 2.54484902707822 1.59240467582976e-06 -2.09940213646525 2.77134949511158e-05 mirMAP -0.146133495085517 0.00444174699182292 NA NA NA hsa-miR-26b-3p NFATC2 2.18464160365372 2.11543189388328e-18 -2.09940213646525 2.77134949511158e-05 MirTarget -0.44806551147109 1.62954234122775e-06 NA NA NA hsa-miR-27b-5p NFATC2 0.393316367667332 0.051702301924024 -2.09940213646525 2.77134949511158e-05 mirMAP -0.365339117485442 0.00275776764973734 NA NA NA hsa-miR-29a-5p NFATC2 1.46749674755271 3.34605004270294e-07 -2.09940213646525 2.77134949511158e-05 mirMAP;miRNATAP -0.294077626911206 0.000928666235522722 NA NA NA hsa-miR-30c-5p NFATC2 0.778774633108 0.000285599212429136 -2.09940213646525 2.77134949511158e-05 MirTarget;mirMAP -0.368293366563006 0.00123567961865253 NA NA NA hsa-miR-30e-5p NFATC2 1.23904909539663 1.35561917122157e-09 -2.09940213646525 2.77134949511158e-05 MirTarget -0.336147434109482 0.00451047767094652 NA NA NA hsa-miR-320a NFATC2 0.438165828017084 0.0390159073347133 -2.09940213646525 2.77134949511158e-05 MirTarget -0.350663524320559 0.00250598418881894 NA NA NA hsa-miR-320b NFATC2 1.55692969039548 1.41071034251915e-08 -2.09940213646525 2.77134949511158e-05 MirTarget -0.249445194387165 0.00451696496700399 NA NA NA hsa-miR-34a-3p NFATC2 1.75590866103657 8.02801510630657e-09 -2.09940213646525 2.77134949511158e-05 mirMAP -0.301138281046132 0.000597201447878319 NA NA NA hsa-miR-3607-3p NFATC2 2.68532138541128 5.66716351955047e-14 -2.09940213646525 2.77134949511158e-05 MirTarget;mirMAP -0.321712713536906 1.93008019978856e-06 NA NA NA hsa-miR-3613-5p NFATC2 2.64358387329263 1.0373753017245e-24 -2.09940213646525 2.77134949511158e-05 mirMAP -0.582140424179043 1.2743589534383e-10 NA NA NA hsa-miR-484 NFATC2 1.81844463411787 1.82951571230938e-15 -2.09940213646525 2.77134949511158e-05 MirTarget -0.38479959768158 0.000202349753737943 NA NA NA hsa-miR-590-3p NFATC2 2.59289455139753 1.03200520972022e-21 -2.09940213646525 2.77134949511158e-05 mirMAP -0.321676608175333 0.000262933617887873 NA NA NA hsa-miR-7-1-3p NFATC2 1.84950311431067 1.25300363397654e-13 -2.09940213646525 2.77134949511158e-05 mirMAP -0.263604719151409 0.00578811798609279 NA NA NA hsa-miR-130b-5p NFATC4 2.9963110846538 1.98883029416455e-18 -1.80092988307702 3.48834735342005e-10 mirMAP -0.137235836741862 0.000756045425262512 NA NA NA hsa-miR-15b-3p NFATC4 2.33847028227712 4.29662877950836e-19 -1.80092988307702 3.48834735342005e-10 mirMAP -0.42678455481147 1.50897022571625e-17 NA NA NA hsa-miR-181a-2-3p NFATC4 2.19062681262366 3.81790102612782e-13 -1.80092988307702 3.48834735342005e-10 mirMAP -0.195817485216201 1.65164425285929e-05 NA NA NA hsa-miR-181a-5p NFATC4 2.29556023480783 1.8138457900616e-21 -1.80092988307702 3.48834735342005e-10 mirMAP -0.232958279655687 3.02940033007413e-05 NA NA NA hsa-miR-181b-5p NFATC4 2.49307679431293 3.92829250217627e-20 -1.80092988307702 3.48834735342005e-10 mirMAP -0.262874063527659 1.04543846165047e-07 NA NA NA hsa-miR-185-3p NFATC4 2.3922478518806 1.3373426768452e-14 -1.80092988307702 3.48834735342005e-10 MirTarget -0.271046230259512 4.4211964130384e-10 NA NA NA hsa-miR-2355-5p NFATC4 1.32510310704724 8.25139516692683e-07 -1.80092988307702 3.48834735342005e-10 MirTarget -0.365394782747818 7.50941976584262e-13 NA NA NA hsa-miR-29b-3p NFATC4 1.65828197923813 1.02676780888141e-09 -1.80092988307702 3.48834735342005e-10 miRNATAP -0.215973494706709 2.3206094912252e-05 NA NA NA hsa-miR-320b NFATC4 1.55692969039548 1.41071034251915e-08 -1.80092988307702 3.48834735342005e-10 miRanda;mirMAP -0.260870260943582 2.24547536842287e-07 NA NA NA hsa-miR-34c-5p NFATC4 2.07190852984647 7.35776320806257e-08 -1.80092988307702 3.48834735342005e-10 miRanda -0.136831648591325 0.000394221428295672 NA NA NA hsa-miR-3607-3p NFATC4 2.68532138541128 5.66716351955047e-14 -1.80092988307702 3.48834735342005e-10 miRNATAP -0.251671136039063 8.25714813158393e-11 NA NA NA hsa-miR-361-3p NFATC4 1.07367425434318 1.73142774168958e-09 -1.80092988307702 3.48834735342005e-10 mirMAP -0.397492986056446 3.76815247508252e-07 NA NA NA hsa-miR-423-5p NFATC4 0.963563145758616 9.86109015204915e-07 -1.80092988307702 3.48834735342005e-10 miRNATAP -0.289483218215484 5.20887036793855e-05 NA NA NA hsa-miR-484 NFATC4 1.81844463411787 1.82951571230938e-15 -1.80092988307702 3.48834735342005e-10 MirTarget;miRNATAP -0.319008427014768 8.35906924043843e-08 NA NA NA hsa-miR-625-5p NFATC4 1.42540152147292 1.95797147911206e-06 -1.80092988307702 3.48834735342005e-10 mirMAP -0.255935845388402 5.19970914763295e-07 NA NA NA hsa-miR-629-3p NFATC4 2.36570947321815 1.33458201201618e-11 -1.80092988307702 3.48834735342005e-10 mirMAP -0.317779815801302 3.14548353729131e-13 NA NA NA hsa-miR-940 NFATC4 3.21011374578759 2.7923171128495e-14 -1.80092988307702 3.48834735342005e-10 miRNATAP -0.168817588938824 1.62478907216658e-06 NA NA NA hsa-miR-450b-5p NFKB1 1.69244418548325 1.68064054148881e-10 -0.64818153460532 4.948433163113e-05 MirTarget;PITA -0.124463449584444 1.35101416784659e-05 NA NA NA hsa-miR-92a-3p NFKB1 2.06460102658973 1.44784291084757e-19 -0.64818153460532 4.948433163113e-05 miRNAWalker2_validate -0.146602812476967 6.42472618908431e-06 NA NA NA hsa-miR-98-5p NFKB2 1.11154309866014 1.24143909012085e-08 -0.0592537499915524 0.723006005363602 miRNAWalker2_validate -0.13772366738974 0.000761879003380977 NA NA NA hsa-let-7a-5p NGF 0.618599506841644 2.76973453058748e-05 -2.40747957908931 8.29529053936123e-07 MirTarget;TargetScan -0.725600120025055 8.99703032904097e-06 NA NA NA hsa-let-7b-5p NGF 0.604314269683977 0.00140009936153214 -2.40747957908931 8.29529053936123e-07 MirTarget -0.445902124296935 0.000457128474125706 NA NA NA hsa-let-7d-5p NGF 1.33236798905207 1.1741085658466e-13 -2.40747957908931 8.29529053936123e-07 MirTarget -0.678554815907685 1.63174808684775e-07 NA NA NA hsa-let-7e-5p NGF 0.860104282510173 6.04758298373779e-05 -2.40747957908931 8.29529053936123e-07 MirTarget -0.426192872238101 0.000127971345995895 NA NA NA hsa-let-7f-5p NGF 0.495648727272215 0.00355972741198794 -2.40747957908931 8.29529053936123e-07 MirTarget -0.599266844830758 2.3727191387735e-05 NA NA NA hsa-let-7g-5p NGF 1.20061455355116 1.50237505511483e-12 -2.40747957908931 8.29529053936123e-07 MirTarget -1.06245785714021 3.64026543085871e-15 NA NA NA hsa-miR-125a-3p NGF 1.24490295132072 5.26925231010328e-06 -2.40747957908931 8.29529053936123e-07 miRanda -0.250797549188537 0.00395961103629666 NA NA NA hsa-miR-320a NGF 0.438165828017084 0.0390159073347133 -2.40747957908931 8.29529053936123e-07 miRanda -0.444107483987704 8.7035614427142e-05 NA NA NA hsa-miR-320b NGF 1.55692969039548 1.41071034251915e-08 -2.40747957908931 8.29529053936123e-07 miRanda -0.423772071383533 6.50389232533904e-07 NA NA NA hsa-miR-423-5p NGF 0.963563145758616 9.86109015204915e-07 -2.40747957908931 8.29529053936123e-07 MirTarget;miRNATAP -0.803354433746443 1.32594577043773e-11 NA NA NA hsa-miR-429 NGF 4.48815175680773 2.44117492218206e-17 -2.40747957908931 8.29529053936123e-07 miRanda -0.382290239888962 2.67088438561565e-20 NA NA NA hsa-miR-98-5p NGF 1.11154309866014 1.24143909012085e-08 -2.40747957908931 8.29529053936123e-07 MirTarget -0.660953034981452 3.88812196488546e-08 NA NA NA hsa-miR-152-3p NLK -0.0480232621705712 0.844347735441565 0.7741568824418 1.00090143680282e-07 MirTarget -0.132317012289272 5.31854788819065e-06 NA NA NA hsa-miR-221-3p NLK 0.451556679024397 0.0909808299917811 0.7741568824418 1.00090143680282e-07 MirTarget;miRNATAP -0.191070870391673 2.07162907329332e-13 NA NA NA hsa-miR-222-3p NLK 0.851783756239071 0.00266783568486918 0.7741568824418 1.00090143680282e-07 MirTarget;miRNATAP -0.161713318218648 4.46385425959352e-11 NA NA NA hsa-miR-222-5p NLK 1.25632771414778 0.000138653440511922 0.7741568824418 1.00090143680282e-07 MirTarget -0.102776820884223 1.32608917229093e-06 NA NA NA hsa-miR-23a-3p NLK 1.00493340843378 2.55313889288924e-08 0.7741568824418 1.00090143680282e-07 miRNAWalker2_validate;MirTarget -0.117869946714833 0.00269411132634791 NA NA NA hsa-miR-27a-3p NLK 1.66542180327138 4.93775737894805e-13 0.7741568824418 1.00090143680282e-07 miRNATAP -0.107481035847716 0.000355550273210407 NA NA NA hsa-let-7d-5p NR4A1 1.33236798905207 1.1741085658466e-13 -4.37235366597705 9.50064560522938e-27 miRNAWalker2_validate -0.607753554509923 9.77690185266994e-08 NA NA NA hsa-miR-125a-3p NR4A1 1.24490295132072 5.26925231010328e-06 -4.37235366597705 9.50064560522938e-27 miRanda -0.253206793926018 0.00093511286530804 26782438 There were no significant correlations between miR-125 expression and other clinicopathological features including tumor size histological grade hormone receptor status Her-2 status and lymph node metastasis metastasis;tumor size breast cancer hsa-miR-196a-5p NR4A1 1.52993069622497 0.00397268663639603 -4.37235366597705 9.50064560522938e-27 miRNAWalker2_validate -0.15198162396951 0.000112144770862419 NA NA NA hsa-miR-324-5p NR4A1 2.95683728155095 1.32960514360912e-20 -4.37235366597705 9.50064560522938e-27 miRanda -0.416525208476142 1.71884245649331e-11 NA NA NA hsa-miR-335-5p NR4A1 1.77247705492746 2.22457658872091e-06 -4.37235366597705 9.50064560522938e-27 miRNAWalker2_validate -0.154428679787295 0.00549636446023487 NA NA NA hsa-miR-361-5p NR4A1 0.971859117235239 5.30236555707088e-09 -4.37235366597705 9.50064560522938e-27 miRanda -0.737728322507883 3.01478134123423e-09 NA NA NA hsa-miR-362-3p NR4A1 2.0756816987665 3.89026064579331e-12 -4.37235366597705 9.50064560522938e-27 miRanda -0.195713614861691 0.00592846562436674 NA NA NA hsa-miR-542-3p NR4A1 1.18832665895751 1.98700670691565e-07 -4.37235366597705 9.50064560522938e-27 PITA;miRanda -0.249806826064396 0.00638202164861832 NA NA NA hsa-miR-93-5p NR4A1 3.03961860136032 1.11672209617395e-24 -4.37235366597705 9.50064560522938e-27 miRNAWalker2_validate -0.442106606247051 1.73647020314414e-11 NA NA NA hsa-miR-29c-3p NRAS -0.00968972577705429 0.97099586346872 0.638705716882092 3.80929355945655e-05 miRNATAP -0.151007715222895 7.79757166468808e-08 NA NA NA hsa-miR-664a-3p NRAS 0.634721925861133 0.00520070178640421 0.638705716882092 3.80929355945655e-05 MirTarget -0.156789929856636 2.10592676639858e-06 NA NA NA hsa-miR-142-3p NTF3 2.75247908790621 1.45636065474764e-12 -3.30762378554694 2.95059143066034e-13 miRanda -0.289559750333271 2.18084109404098e-07 NA NA NA hsa-miR-21-5p NTF3 2.73773305747971 1.38864982139576e-43 -3.30762378554694 2.95059143066034e-13 miRTarBase;miRNATAP -0.718377718022019 1.14136463226806e-12 NA NA NA hsa-miR-221-3p NTF3 0.451556679024397 0.0909808299917811 -3.30762378554694 2.95059143066034e-13 miRNATAP -0.464707209676713 2.88362012880969e-08 NA NA NA hsa-miR-222-3p NTF3 0.851783756239071 0.00266783568486918 -3.30762378554694 2.95059143066034e-13 miRNATAP -0.529220907365481 1.05244018417693e-11 NA NA NA hsa-miR-421 NTF3 1.17791565395543 6.78526676976629e-06 -3.30762378554694 2.95059143066034e-13 miRanda -0.227952411175781 0.00806835785015479 NA NA NA hsa-miR-590-3p NTF3 2.59289455139753 1.03200520972022e-21 -3.30762378554694 2.95059143066034e-13 miRanda -0.340175587260053 2.82489458563848e-05 NA NA NA hsa-miR-590-5p NTF3 3.18300989862077 2.06813568597893e-26 -3.30762378554694 2.95059143066034e-13 PITA;miRanda;miRNATAP -0.33125375143849 4.71667151153976e-06 NA NA NA hsa-miR-107 NTRK2 1.30977326593435 1.30372468603965e-11 -3.4444884279512 9.02401971614574e-08 PITA;miRanda -1.10328807131129 2.46161403963682e-12 NA NA NA hsa-miR-125a-3p NTRK2 1.24490295132072 5.26925231010328e-06 -3.4444884279512 9.02401971614574e-08 miRanda -0.376033016875365 0.00107171920041796 NA NA NA hsa-miR-126-5p NTRK2 0.895338176458417 2.33372756450713e-05 -3.4444884279512 9.02401971614574e-08 mirMAP -0.461947070179665 0.00199468881131289 NA NA NA hsa-miR-130b-3p NTRK2 3.5350292994509 1.73934183852569e-27 -3.4444884279512 9.02401971614574e-08 mirMAP -0.655009379767134 1.53407544109055e-13 NA NA NA hsa-miR-130b-5p NTRK2 2.9963110846538 1.98883029416455e-18 -3.4444884279512 9.02401971614574e-08 mirMAP -0.664721546737953 6.35250159481337e-14 NA NA NA hsa-miR-151a-5p NTRK2 2.32422038747303 2.66226949101065e-18 -3.4444884279512 9.02401971614574e-08 miRNATAP -0.871234808600496 3.71142225770198e-15 NA NA NA hsa-miR-15b-3p NTRK2 2.33847028227712 4.29662877950836e-19 -3.4444884279512 9.02401971614574e-08 mirMAP -0.78865263855268 3.47760542097815e-12 NA NA NA hsa-miR-17-3p NTRK2 2.2704817679209 1.1667437320211e-22 -3.4444884279512 9.02401971614574e-08 miRNATAP -0.986404899520973 5.60866733893115e-15 NA NA NA hsa-miR-181a-5p NTRK2 2.29556023480783 1.8138457900616e-21 -3.4444884279512 9.02401971614574e-08 mirMAP -0.641712336343684 2.29468859355526e-07 NA NA NA hsa-miR-181b-5p NTRK2 2.49307679431293 3.92829250217627e-20 -3.4444884279512 9.02401971614574e-08 mirMAP -0.623644911740744 1.48869667340713e-08 NA NA NA hsa-miR-181c-5p NTRK2 1.58587920618301 1.57506918816933e-10 -3.4444884279512 9.02401971614574e-08 mirMAP -0.487056006099362 9.7916777419054e-05 NA NA NA hsa-miR-182-5p NTRK2 3.53923166221814 5.07781258121574e-21 -3.4444884279512 9.02401971614574e-08 mirMAP -0.542854638305866 3.89545557204651e-12 NA NA NA hsa-miR-185-5p NTRK2 2.34016206907488 1.17481626642022e-26 -3.4444884279512 9.02401971614574e-08 mirMAP -0.908221744534185 1.04154350912728e-11 NA NA NA hsa-miR-186-5p NTRK2 1.47445398888668 3.0781726595413e-15 -3.4444884279512 9.02401971614574e-08 mirMAP -1.08361132863423 2.28591646607224e-11 NA NA NA hsa-miR-200c-3p NTRK2 3.50132673580082 2.42716349086937e-15 -3.4444884279512 9.02401971614574e-08 miRNAWalker2_validate;miRTarBase -0.558218294130396 5.1648144515451e-17 23209748;23074172 miR 200c sensitizes breast cancer cells to doxorubicin treatment by decreasing TrkB and Bmi1 expression;miR-200c also targets TrkB a mediator of resistance to anoikis ;drug resistance breast cancer;ovarian cancer hsa-miR-20a-3p NTRK2 2.92621109947706 2.49504904635375e-17 -3.4444884279512 9.02401971614574e-08 mirMAP -0.638958030834559 4.2820526373737e-13 NA NA NA hsa-miR-21-5p NTRK2 2.73773305747971 1.38864982139576e-43 -3.4444884279512 9.02401971614574e-08 mirMAP -0.426222870969759 0.00330777931884449 NA NA NA hsa-miR-22-3p NTRK2 1.21545661147757 1.61670170137775e-13 -3.4444884279512 9.02401971614574e-08 miRNATAP -0.792113978350115 2.65895272261461e-05 27662840 NTRK2 is an oncogene and associated with microRNA 22 regulation in human gastric cancer cell lines; The upstream regulator of NTRK2 microRNA-22 miR-22 was evaluated by dual-luciferase assay; In miR-22-upregulated MKN-28 and SNU-719 cells NTRK2 was further overexpressed to evaluate functional interaction between miR-22 and NTRK2 in GC; MiR-22 was verified to be an inverse upstream regulator of NTRK2; NTRK2 is an oncogene and reversely associated with miR-22 in regulating in vitro cancer development in GC gastric cancer hsa-miR-224-3p NTRK2 1.87536386559317 6.15140969394846e-05 -3.4444884279512 9.02401971614574e-08 mirMAP -0.251953296536257 0.000320280319633908 NA NA NA hsa-miR-26b-5p NTRK2 0.885393662798425 3.2116297961629e-06 -3.4444884279512 9.02401971614574e-08 mirMAP -0.918548097668709 2.31015434348151e-08 NA NA NA hsa-miR-29a-5p NTRK2 1.46749674755271 3.34605004270294e-07 -3.4444884279512 9.02401971614574e-08 mirMAP -0.413787908321922 0.000315700519378732 NA NA NA hsa-miR-301a-3p NTRK2 2.81024345929638 2.29784847962242e-17 -3.4444884279512 9.02401971614574e-08 mirMAP -0.744969523901533 2.39919848998948e-15 NA NA NA hsa-miR-3065-5p NTRK2 2.74629919868982 1.86846589298284e-08 -3.4444884279512 9.02401971614574e-08 mirMAP -0.286324800403609 0.00023527787223171 NA NA NA hsa-miR-30b-5p NTRK2 0.800822374912712 0.000133601914525413 -3.4444884279512 9.02401971614574e-08 mirMAP -0.546689649319654 0.00029099120653431 NA NA NA hsa-miR-30c-5p NTRK2 0.778774633108 0.000285599212429136 -3.4444884279512 9.02401971614574e-08 mirMAP -0.689336493365858 2.58508921415882e-06 NA NA NA hsa-miR-30d-3p NTRK2 0.977747550180601 4.3048212205381e-05 -3.4444884279512 9.02401971614574e-08 mirMAP -0.665503813522632 3.72555641617031e-07 NA NA NA hsa-miR-30d-5p NTRK2 0.675423997639582 0.00270618816039773 -3.4444884279512 9.02401971614574e-08 mirMAP -0.687091926033502 8.8466750322348e-07 NA NA NA hsa-miR-30e-3p NTRK2 -0.215663037684509 0.235375122783546 -3.4444884279512 9.02401971614574e-08 mirMAP -0.560142851781332 0.00151121456503575 NA NA NA hsa-miR-30e-5p NTRK2 1.23904909539663 1.35561917122157e-09 -3.4444884279512 9.02401971614574e-08 mirMAP -0.997379711717577 3.00290798335836e-11 NA NA NA hsa-miR-32-3p NTRK2 2.02436999565685 5.94091197945307e-09 -3.4444884279512 9.02401971614574e-08 mirMAP -0.59869849424457 2.50361692819518e-09 NA NA NA hsa-miR-32-5p NTRK2 2.34056473219422 6.24134585974322e-20 -3.4444884279512 9.02401971614574e-08 mirMAP -0.794984558850216 6.67646054442438e-12 NA NA NA hsa-miR-320a NTRK2 0.438165828017084 0.0390159073347133 -3.4444884279512 9.02401971614574e-08 mirMAP -0.708471038497037 2.00258734327495e-06 NA NA NA hsa-miR-320b NTRK2 1.55692969039548 1.41071034251915e-08 -3.4444884279512 9.02401971614574e-08 mirMAP -0.748159964114521 1.79959199577157e-11 NA NA NA hsa-miR-326 NTRK2 0.715313016136042 0.0610265683213359 -3.4444884279512 9.02401971614574e-08 miRanda -0.314908565253097 0.000146783251679974 NA NA NA hsa-miR-330-5p NTRK2 1.15100069700871 4.85551805046014e-07 -3.4444884279512 9.02401971614574e-08 miRanda -0.797396566610236 3.87824675584644e-09 NA NA NA hsa-miR-335-3p NTRK2 3.08791651139852 5.31309869723517e-12 -3.4444884279512 9.02401971614574e-08 mirMAP -0.325799033294531 1.77950710082574e-06 NA NA NA hsa-miR-335-5p NTRK2 1.77247705492746 2.22457658872091e-06 -3.4444884279512 9.02401971614574e-08 miRNAWalker2_validate -0.306339245672051 0.000234367118729164 NA NA NA hsa-miR-339-5p NTRK2 2.68710938429893 3.03134080808154e-16 -3.4444884279512 9.02401971614574e-08 miRanda -0.473102823273484 2.60419080375085e-07 NA NA NA hsa-miR-33a-5p NTRK2 3.79671563098419 1.15966309820345e-18 -3.4444884279512 9.02401971614574e-08 mirMAP -0.446714130551512 3.20996972838069e-09 NA NA NA hsa-miR-34a-3p NTRK2 1.75590866103657 8.02801510630657e-09 -3.4444884279512 9.02401971614574e-08 mirMAP -0.545493213319934 1.33340706209908e-06 NA NA NA hsa-miR-361-5p NTRK2 0.971859117235239 5.30236555707088e-09 -3.4444884279512 9.02401971614574e-08 miRanda;mirMAP -1.17870891609401 2.52271895231875e-10 NA NA NA hsa-miR-362-5p NTRK2 1.59303749908759 9.582675908797e-08 -3.4444884279512 9.02401971614574e-08 mirMAP -0.34256739087268 0.0010450304175508 NA NA NA hsa-miR-421 NTRK2 1.17791565395543 6.78526676976629e-06 -3.4444884279512 9.02401971614574e-08 mirMAP -0.388652077576734 0.00124164792398222 NA NA NA hsa-miR-429 NTRK2 4.48815175680773 2.44117492218206e-17 -3.4444884279512 9.02401971614574e-08 PITA;miRanda;miRNATAP -0.439212754909065 2.46588001463114e-15 NA NA NA hsa-miR-454-3p NTRK2 2.47234127820054 1.12878018736016e-21 -3.4444884279512 9.02401971614574e-08 mirMAP -0.84994308142847 3.69480447340161e-13 NA NA NA hsa-miR-455-3p NTRK2 3.06093594997644 3.54590649799868e-16 -3.4444884279512 9.02401971614574e-08 mirMAP -0.417652226788031 2.01737423577491e-07 NA NA NA hsa-miR-501-5p NTRK2 1.93654809410041 1.3779381780759e-10 -3.4444884279512 9.02401971614574e-08 mirMAP -0.515062812169395 9.14107888272414e-07 NA NA NA hsa-miR-532-5p NTRK2 1.55697650978597 1.57884735535196e-11 -3.4444884279512 9.02401971614574e-08 PITA -0.662294968429731 6.6852568807782e-07 NA NA NA hsa-miR-576-5p NTRK2 2.20467023993664 3.4053475193793e-19 -3.4444884279512 9.02401971614574e-08 PITA;mirMAP -0.790847254437626 6.52457580482194e-11 NA NA NA hsa-miR-590-3p NTRK2 2.59289455139753 1.03200520972022e-21 -3.4444884279512 9.02401971614574e-08 PITA;miRanda;mirMAP -0.620306339153694 4.06542783004907e-08 NA NA NA hsa-miR-590-5p NTRK2 3.18300989862077 2.06813568597893e-26 -3.4444884279512 9.02401971614574e-08 miRanda;mirMAP -0.735662775454248 1.39412676341035e-13 NA NA NA hsa-miR-940 NTRK2 3.21011374578759 2.7923171128495e-14 -3.4444884279512 9.02401971614574e-08 PITA -0.574117798651102 9.91369577061371e-14 NA NA NA hsa-let-7e-5p PAK1 0.860104282510173 6.04758298373779e-05 -0.260585931173264 0.175229696873286 miRNATAP -0.1369917481953 0.00153436045412213 NA NA NA hsa-miR-320b PDGFA 1.55692969039548 1.41071034251915e-08 -0.102054427352152 0.706957288628846 miRanda -0.127864638339372 0.00663582990083202 NA NA NA hsa-miR-331-5p PDGFA 2.17414714166315 1.54547681391888e-18 -0.102054427352152 0.706957288628846 PITA;miRNATAP -0.160783001474425 0.00212874646023858 NA NA NA hsa-miR-421 PDGFA 1.17791565395543 6.78526676976629e-06 -0.102054427352152 0.706957288628846 miRanda -0.169357059547879 0.000668658673908117 NA NA NA hsa-miR-484 PDGFA 1.81844463411787 1.82951571230938e-15 -0.102054427352152 0.706957288628846 PITA;miRNATAP -0.163420399065966 0.00333081226843222 NA NA NA hsa-miR-590-3p PDGFA 2.59289455139753 1.03200520972022e-21 -0.102054427352152 0.706957288628846 miRanda -0.133975078033997 0.0047011572526004 NA NA NA hsa-miR-590-5p PDGFA 3.18300989862077 2.06813568597893e-26 -0.102054427352152 0.706957288628846 miRanda -0.136216823398504 0.00126211188867757 NA NA NA hsa-let-7a-5p PDGFB 0.618599506841644 2.76973453058748e-05 0.496610054270869 0.0653962924185686 TargetScan;miRNATAP -0.34611820876839 0.000105030069604701 NA NA NA hsa-let-7f-5p PDGFB 0.495648727272215 0.00355972741198794 0.496610054270869 0.0653962924185686 miRNATAP -0.230786895213123 0.00294626570770709 NA NA NA hsa-let-7g-5p PDGFB 1.20061455355116 1.50237505511483e-12 0.496610054270869 0.0653962924185686 miRNATAP -0.228771312890516 0.00256055086878667 NA NA NA hsa-miR-29b-2-5p PDGFB 0.910668640983475 0.00666655585493488 0.496610054270869 0.0653962924185686 mirMAP -0.139091152849383 0.000325402180502362 NA NA NA hsa-miR-29c-3p PDGFB -0.00968972577705429 0.97099586346872 0.496610054270869 0.0653962924185686 MirTarget;miRNATAP -0.136061870879976 0.00568361134251952 NA NA NA hsa-let-7a-3p PDGFRA 1.42015538786275 7.03375209382654e-13 -2.37640583073564 1.39737819859365e-09 mirMAP -0.548764001510131 6.84820893227166e-09 NA NA NA hsa-let-7b-3p PDGFRA 0.868207752019623 1.30460056774366e-05 -2.37640583073564 1.39737819859365e-09 mirMAP -0.344538450812629 0.000386110125844406 NA NA NA hsa-let-7b-5p PDGFRA 0.604314269683977 0.00140009936153214 -2.37640583073564 1.39737819859365e-09 miRNAWalker2_validate -0.521190235799922 3.3085772165913e-07 NA NA NA hsa-let-7f-1-3p PDGFRA 1.55054488387679 7.31326775537952e-11 -2.37640583073564 1.39737819859365e-09 mirMAP -0.255636194946609 0.00187448794686435 NA NA NA hsa-let-7g-3p PDGFRA 3.26398061402445 3.96263126107645e-25 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.513984859053283 2.05725197047486e-19 NA NA NA hsa-miR-106a-5p PDGFRA 2.48882002962836 1.99757727374521e-12 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.371298633316283 8.91032038900892e-13 NA NA NA hsa-miR-106b-5p PDGFRA 2.46782146831112 1.36171495805632e-23 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.735956870099196 1.34297971882591e-25 NA NA NA hsa-miR-129-5p PDGFRA -0.524170159980738 0.222582956006346 -2.37640583073564 1.39737819859365e-09 miRanda;mirMAP;miRNATAP -0.128621152047043 0.0051316212954247 NA NA NA hsa-miR-130a-3p PDGFRA 2.02021855058359 1.26427102520415e-11 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.233330487651072 0.000224564945662775 NA NA NA hsa-miR-130b-3p PDGFRA 3.5350292994509 1.73934183852569e-27 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.443010230539233 1.9085252314885e-16 NA NA NA hsa-miR-141-3p PDGFRA 5.02396127982626 2.19224509139725e-24 -2.37640583073564 1.39737819859365e-09 MirTarget -0.379513640202387 7.11112956696243e-28 NA NA NA hsa-miR-149-5p PDGFRA 2.94200492826326 4.93436498919036e-14 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.2660799579696 1.94629645007035e-08 NA NA NA hsa-miR-16-1-3p PDGFRA 2.56983217111073 3.02262181237943e-20 -2.37640583073564 1.39737819859365e-09 MirTarget -0.523089278771913 2.57639641644736e-15 NA NA NA hsa-miR-17-5p PDGFRA 3.2710598467455 9.93128340539455e-27 -2.37640583073564 1.39737819859365e-09 MirTarget;TargetScan;miRNATAP -0.553748753585946 1.23397121105114e-22 NA NA NA hsa-miR-181b-5p PDGFRA 2.49307679431293 3.92829250217627e-20 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.246762118189355 0.000291477558580384 NA NA NA hsa-miR-182-5p PDGFRA 3.53923166221814 5.07781258121574e-21 -2.37640583073564 1.39737819859365e-09 miRNATAP -0.375439590705967 2.48477058044486e-15 NA NA NA hsa-miR-186-5p PDGFRA 1.47445398888668 3.0781726595413e-15 -2.37640583073564 1.39737819859365e-09 MirTarget -0.700421064109499 1.35088148765239e-12 NA NA NA hsa-miR-196a-5p PDGFRA 1.52993069622497 0.00397268663639603 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.124523334352829 0.000586053454058574 NA NA NA hsa-miR-196b-5p PDGFRA 1.71646270856386 4.37735885910369e-09 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.290309745460117 7.22286389037591e-06 NA NA NA hsa-miR-200a-3p PDGFRA 4.59434485520731 6.38952518573476e-18 -2.37640583073564 1.39737819859365e-09 MirTarget -0.30020684009978 2.24739680558458e-19 NA NA NA hsa-miR-20a-5p PDGFRA 3.15577933619191 4.19753346442454e-25 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.536531231590286 6.48676718494673e-21 NA NA NA hsa-miR-20b-5p PDGFRA 2.07706563022469 1.10107236083433e-05 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.200276264854919 5.98530623190359e-07 NA NA NA hsa-miR-2110 PDGFRA 1.16625590651194 6.4784195289885e-05 -2.37640583073564 1.39737819859365e-09 MirTarget -0.367427900079696 1.6178582537556e-07 NA NA NA hsa-miR-224-5p PDGFRA 2.94107125335675 5.72194099515157e-08 -2.37640583073564 1.39737819859365e-09 MirTarget -0.18329230997559 1.26828530884065e-07 NA NA NA hsa-miR-24-3p PDGFRA 0.99989036772428 1.35595013650376e-07 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.445666887182499 1.04888902991557e-05 NA NA NA hsa-miR-26b-5p PDGFRA 0.885393662798425 3.2116297961629e-06 -2.37640583073564 1.39737819859365e-09 miRNAWalker2_validate;MirTarget;mirMAP;miRNATAP -0.434540118830339 1.79640152621153e-05 NA NA NA hsa-miR-27a-3p PDGFRA 1.66542180327138 4.93775737894805e-13 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.231732831890339 0.00480656820974615 NA NA NA hsa-miR-29b-2-5p PDGFRA 0.910668640983475 0.00666655585493488 -2.37640583073564 1.39737819859365e-09 mirMAP -0.249967909040798 1.27931881284481e-05 NA NA NA hsa-miR-29b-3p PDGFRA 1.65828197923813 1.02676780888141e-09 -2.37640583073564 1.39737819859365e-09 MirTarget -0.200668467003426 0.00420946019654394 NA NA NA hsa-miR-301a-3p PDGFRA 2.81024345929638 2.29784847962242e-17 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.508684565933966 4.36558822645561e-19 NA NA NA hsa-miR-3065-5p PDGFRA 2.74629919868982 1.86846589298284e-08 -2.37640583073564 1.39737819859365e-09 mirMAP -0.166254695248905 0.00048554613178076 NA NA NA hsa-miR-320a PDGFRA 0.438165828017084 0.0390159073347133 -2.37640583073564 1.39737819859365e-09 miRanda -0.402889384468968 1.02856691876917e-05 NA NA NA hsa-miR-320b PDGFRA 1.55692969039548 1.41071034251915e-08 -2.37640583073564 1.39737819859365e-09 miRanda -0.519602099473307 1.42131525257444e-14 NA NA NA hsa-miR-330-5p PDGFRA 1.15100069700871 4.85551805046014e-07 -2.37640583073564 1.39737819859365e-09 miRanda -0.45163495328704 5.41294182541652e-08 NA NA NA hsa-miR-335-3p PDGFRA 3.08791651139852 5.31309869723517e-12 -2.37640583073564 1.39737819859365e-09 mirMAP -0.14687583518123 0.000466962608053098 NA NA NA hsa-miR-339-5p PDGFRA 2.68710938429893 3.03134080808154e-16 -2.37640583073564 1.39737819859365e-09 miRanda -0.338543405646925 1.34989847950552e-09 NA NA NA hsa-miR-33a-5p PDGFRA 3.79671563098419 1.15966309820345e-18 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.396871470489045 1.19728989197256e-18 NA NA NA hsa-miR-34a-5p PDGFRA 1.9016323452565 1.43092834643601e-14 -2.37640583073564 1.39737819859365e-09 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.295453243484317 9.87541559838975e-05 22750848 Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network glioblastoma hsa-miR-34c-5p PDGFRA 2.07190852984647 7.35776320806257e-08 -2.37640583073564 1.39737819859365e-09 MirTarget;PITA;miRanda;miRNATAP -0.225762830573297 1.74081263395182e-05 NA NA NA hsa-miR-362-3p PDGFRA 2.0756816987665 3.89026064579331e-12 -2.37640583073564 1.39737819859365e-09 miRanda -0.2120805244561 0.00115047466173652 NA NA NA hsa-miR-374a-5p PDGFRA 0.484615721953736 0.0042981729815149 -2.37640583073564 1.39737819859365e-09 mirMAP -0.336442959314977 0.00360859152849973 NA NA NA hsa-miR-421 PDGFRA 1.17791565395543 6.78526676976629e-06 -2.37640583073564 1.39737819859365e-09 PITA;miRanda;miRNATAP -0.474589953500027 4.96575533912116e-11 NA NA NA hsa-miR-429 PDGFRA 4.48815175680773 2.44117492218206e-17 -2.37640583073564 1.39737819859365e-09 miRanda;miRNATAP -0.283783064999005 4.47719067465487e-17 NA NA NA hsa-miR-454-3p PDGFRA 2.47234127820054 1.12878018736016e-21 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.54069398402006 3.51649522550592e-14 NA NA NA hsa-miR-491-5p PDGFRA 0.615770352820862 0.0418295628761654 -2.37640583073564 1.39737819859365e-09 MirTarget;PITA;miRanda;miRNATAP -0.259675783066868 0.000149579704439114 NA NA NA hsa-miR-550a-5p PDGFRA 2.11025227932763 6.94489556637146e-12 -2.37640583073564 1.39737819859365e-09 MirTarget -0.450686953718593 5.51129161245862e-14 NA NA NA hsa-miR-576-5p PDGFRA 2.20467023993664 3.4053475193793e-19 -2.37640583073564 1.39737819859365e-09 mirMAP -0.494558915423906 2.30135204635613e-11 NA NA NA hsa-miR-589-3p PDGFRA 2.51971841868825 2.39125940264107e-11 -2.37640583073564 1.39737819859365e-09 mirMAP -0.375875993689772 1.70404670310081e-11 NA NA NA hsa-miR-590-3p PDGFRA 2.59289455139753 1.03200520972022e-21 -2.37640583073564 1.39737819859365e-09 miRanda;mirMAP -0.493181031896196 4.96463414718196e-13 NA NA NA hsa-miR-590-5p PDGFRA 3.18300989862077 2.06813568597893e-26 -2.37640583073564 1.39737819859365e-09 miRanda -0.507406338027508 3.77905121698734e-17 NA NA NA hsa-miR-7-1-3p PDGFRA 1.84950311431067 1.25300363397654e-13 -2.37640583073564 1.39737819859365e-09 mirMAP -0.533746456815578 4.42305082401204e-13 NA NA NA hsa-miR-93-5p PDGFRA 3.03961860136032 1.11672209617395e-24 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.564676380038124 7.42892698232966e-22 NA NA NA hsa-miR-944 PDGFRA 2.91186649218281 1.31574753528144e-06 -2.37640583073564 1.39737819859365e-09 mirMAP -0.271450894098107 7.2626459248576e-18 NA NA NA hsa-miR-96-5p PDGFRA 4.89433085814374 1.92000659886961e-31 -2.37640583073564 1.39737819859365e-09 TargetScan;miRNATAP -0.372021838983214 1.0707043407444e-18 NA NA NA hsa-miR-224-5p PDGFRB 2.94107125335675 5.72194099515157e-08 -1.03522303801072 0.00301738788961229 miRNAWalker2_validate -0.147943334000896 1.16237114575095e-06 NA NA NA hsa-miR-24-3p PDGFRB 0.99989036772428 1.35595013650376e-07 -1.03522303801072 0.00301738788961229 MirTarget -0.297654000867495 0.000814454894038923 NA NA NA hsa-miR-29b-3p PDGFRB 1.65828197923813 1.02676780888141e-09 -1.03522303801072 0.00301738788961229 miRNATAP -0.292671948645054 1.48415268440158e-06 NA NA NA hsa-miR-29c-3p PDGFRB -0.00968972577705429 0.97099586346872 -1.03522303801072 0.00301738788961229 miRNATAP -0.359274369001045 1.19150158465265e-08 NA NA NA hsa-miR-3127-5p PDGFRB 1.51846438737133 3.59571251672767e-07 -1.03522303801072 0.00301738788961229 mirMAP -0.437942367228042 7.35571780732733e-16 NA NA NA hsa-miR-34a-5p PDGFRB 1.9016323452565 1.43092834643601e-14 -1.03522303801072 0.00301738788961229 MirTarget -0.3682858109356 2.13745951637981e-08 24837198 MicroRNA 34A inhibits the growth invasion and metastasis of gastric cancer by targeting PDGFR and MET expression; In this study our aim was to identify the miRNAs that target PDGFR-α/β and to study the functions of these miRNAs miR-34a was predicted to target PDGFR and luciferase reporter assays showed that miR-34a could directly target PDGFR; Moreover the cancer-associated cell signalling pathway was studied and we found that miR-34a could inhibit Akt PKB protein kinase B phosphorylation which was restored by the overexpression of both PDGFR and MET; In conclusion miR-34a may act as a potential tumour suppressor in gastric cancer and is associated with the mechanisms of gastric cancer metastasis; miR-34a can inhibit gastric cancer tumourigenesis by targeting PDGFR and MET through the PI3K phosphoinositide 3-kinase/Akt pathway metastasis gastric cancer hsa-miR-361-3p PDGFRB 1.07367425434318 1.73142774168958e-09 -1.03522303801072 0.00301738788961229 MirTarget -0.272631369423021 0.00390272618180474 NA NA NA hsa-miR-421 PDGFRB 1.17791565395543 6.78526676976629e-06 -1.03522303801072 0.00301738788961229 miRanda -0.344304119846965 6.47537980961128e-08 NA NA NA hsa-miR-484 PDGFRB 1.81844463411787 1.82951571230938e-15 -1.03522303801072 0.00301738788961229 mirMAP -0.430712318832622 1.16944218559625e-09 NA NA NA hsa-miR-486-5p PDGFRB -0.194913133034028 0.607377798807705 -1.03522303801072 0.00301738788961229 miRanda -0.172192912820644 0.000110418260727812 NA NA NA hsa-miR-491-5p PDGFRB 0.615770352820862 0.0418295628761654 -1.03522303801072 0.00301738788961229 miRanda -0.236736729792446 7.68579463655803e-05 NA NA NA hsa-miR-664a-3p PDGFRB 0.634721925861133 0.00520070178640421 -1.03522303801072 0.00301738788961229 MirTarget -0.524307398841617 6.92902562319671e-13 NA NA NA hsa-miR-9-5p PDGFRB 1.02304182473283 0.042901377604859 -1.03522303801072 0.00301738788961229 MirTarget;miRNATAP -0.128055325842353 0.000120423195513495 NA NA NA hsa-miR-140-5p PLA2G12A 0.844753502512594 3.73722278438606e-05 -0.226923565397224 0.110320132886187 miRanda -0.14801862288608 8.44927388616416e-06 NA NA NA hsa-miR-142-3p PLA2G12A 2.75247908790621 1.45636065474764e-12 -0.226923565397224 0.110320132886187 miRanda -0.132479438643194 1.31230119499281e-15 NA NA NA hsa-miR-142-5p PLA2G12A 1.17581605694506 0.0018174701991234 -0.226923565397224 0.110320132886187 mirMAP -0.152006113752674 2.16543248749224e-18 NA NA NA hsa-miR-29a-5p PLA2G12A 1.46749674755271 3.34605004270294e-07 -0.226923565397224 0.110320132886187 mirMAP -0.162300143536253 2.86585419004462e-11 NA NA NA hsa-miR-361-5p PLA2G2A 0.971859117235239 5.30236555707088e-09 -3.40473736904758 6.12351716198306e-05 miRanda -1.54030311209047 2.69460491948461e-10 NA NA NA hsa-miR-491-5p PLA2G2A 0.615770352820862 0.0418295628761654 -3.40473736904758 6.12351716198306e-05 miRanda -0.808306666640749 2.54440652464924e-08 NA NA NA hsa-miR-15a-5p PLA2G2D 2.34669284378787 1.69544424500258e-23 -1.02276507955976 0.189798951526849 miRNAWalker2_validate -0.404850472000017 0.00807397819916615 NA NA NA hsa-miR-16-1-3p PLA2G2D 2.56983217111073 3.02262181237943e-20 -1.02276507955976 0.189798951526849 mirMAP -0.48415802760318 0.000261010539116146 NA NA NA hsa-miR-125b-5p PLA2G2F -1.16462950151259 0.000288900271798384 3.13177891691247 0.00146365751535567 mirMAP -0.775103233945353 1.21552641246288e-07 NA NA NA hsa-miR-18a-3p PLA2G2F 2.14813400940323 2.23460809936028e-06 3.13177891691247 0.00146365751535567 mirMAP -0.485063580878413 0.000219436625550264 NA NA NA hsa-miR-2355-5p PLA2G2F 1.32510310704724 8.25139516692683e-07 3.13177891691247 0.00146365751535567 MirTarget -0.725846284205262 3.52692947225181e-05 NA NA NA hsa-miR-1301-3p PLA2G4A 2.54959518791507 5.26618591274892e-18 -1.76911972497501 1.36780052043494e-06 MirTarget -0.271432528908166 2.86828986780574e-06 NA NA NA hsa-miR-142-3p PLA2G4A 2.75247908790621 1.45636065474764e-12 -1.76911972497501 1.36780052043494e-06 miRanda -0.13710181671413 0.00221782421174375 NA NA NA hsa-miR-146b-5p PLA2G4A 1.75587235896724 1.15724631266659e-07 -1.76911972497501 1.36780052043494e-06 miRNAWalker2_validate -0.138508703164524 0.00953802605681816 NA NA NA hsa-miR-181a-5p PLA2G4A 2.29556023480783 1.8138457900616e-21 -1.76911972497501 1.36780052043494e-06 MirTarget -0.210530558529152 0.00302794528753118 NA NA NA hsa-miR-181c-5p PLA2G4A 1.58587920618301 1.57506918816933e-10 -1.76911972497501 1.36780052043494e-06 MirTarget -0.263675364814697 0.000199093485008343 NA NA NA hsa-miR-181d-5p PLA2G4A 1.52204912185579 9.2693319057748e-08 -1.76911972497501 1.36780052043494e-06 MirTarget -0.190977664531932 0.00213336065376659 NA NA NA hsa-miR-33a-3p PLA2G4A 1.72765312072219 1.51784443453521e-07 -1.76911972497501 1.36780052043494e-06 MirTarget -0.156816958703784 0.00805830236676267 NA NA NA hsa-miR-361-5p PLA2G4A 0.971859117235239 5.30236555707088e-09 -1.76911972497501 1.36780052043494e-06 miRanda -0.44352221685407 3.38401198401618e-05 NA NA NA hsa-miR-362-3p PLA2G4A 2.0756816987665 3.89026064579331e-12 -1.76911972497501 1.36780052043494e-06 miRanda -0.344359237218545 7.62718654263185e-09 NA NA NA hsa-miR-590-3p PLA2G4A 2.59289455139753 1.03200520972022e-21 -1.76911972497501 1.36780052043494e-06 miRanda -0.330281844381331 2.6395869433225e-07 NA NA NA hsa-miR-664a-3p PLA2G4E 0.634721925861133 0.00520070178640421 -0.457051657544898 0.526340607142826 mirMAP -0.528605473505062 0.000587247707984126 NA NA NA hsa-miR-125a-5p PLA2G5 0.599529391575274 0.0102300147180307 -2.98039017984699 5.45430675918713e-08 miRanda -0.43402319502752 0.000171953535886849 NA NA NA hsa-miR-128-3p PLA2G5 1.63756041666078 6.79626586407187e-14 -2.98039017984699 5.45430675918713e-08 miRNAWalker2_validate -1.13154129122494 4.25362784424371e-23 NA NA NA hsa-miR-330-5p PLA2G5 1.15100069700871 4.85551805046014e-07 -2.98039017984699 5.45430675918713e-08 miRanda -0.87956954375258 9.6120825351781e-15 NA NA NA hsa-miR-339-5p PLA2G5 2.68710938429893 3.03134080808154e-16 -2.98039017984699 5.45430675918713e-08 miRanda -0.538476541600716 3.05043859695343e-12 NA NA NA hsa-miR-361-5p PLA2G5 0.971859117235239 5.30236555707088e-09 -2.98039017984699 5.45430675918713e-08 miRanda -1.68294189322315 8.66159008701736e-29 NA NA NA hsa-miR-429 PLA2G5 4.48815175680773 2.44117492218206e-17 -2.98039017984699 5.45430675918713e-08 miRanda -0.491944311759968 7.17164621174772e-27 NA NA NA hsa-miR-589-3p PLA2G5 2.51971841868825 2.39125940264107e-11 -2.98039017984699 5.45430675918713e-08 MirTarget -0.606412431420136 3.35739867930122e-15 NA NA NA hsa-miR-590-3p PLA2G5 2.59289455139753 1.03200520972022e-21 -2.98039017984699 5.45430675918713e-08 miRanda;miRNATAP -0.839581331965807 2.56966308437666e-19 NA NA NA hsa-miR-590-5p PLA2G5 3.18300989862077 2.06813568597893e-26 -2.98039017984699 5.45430675918713e-08 miRanda -0.832629471378237 5.18479097856289e-24 NA NA NA hsa-miR-2355-3p PLA2G6 1.2671753520641 5.70559238344897e-05 0.223163826700851 0.393344374716363 MirTarget -0.267411816628485 2.66963375924508e-11 NA NA NA hsa-miR-126-5p PPM1A 0.895338176458417 2.33372756450713e-05 -0.394847284284923 0.000386558346157747 mirMAP -0.127869228196242 3.65744174223156e-07 NA NA NA hsa-miR-140-3p PPM1A 0.0608890720479334 0.727716871248724 -0.394847284284923 0.000386558346157747 miRNATAP -0.147219643416574 2.05573550539347e-06 NA NA NA hsa-miR-186-5p PPM1A 1.47445398888668 3.0781726595413e-15 -0.394847284284923 0.000386558346157747 mirMAP;miRNATAP -0.123282836930579 1.01951962543458e-05 NA NA NA hsa-miR-30a-5p PPM1A -0.878357906436456 0.000509952992366057 -0.394847284284923 0.000386558346157747 miRNATAP -0.10452279116903 6.92936451057101e-07 NA NA NA hsa-miR-30c-5p PPM1A 0.778774633108 0.000285599212429136 -0.394847284284923 0.000386558346157747 miRNATAP -0.105217376464015 2.50951731367666e-05 NA NA NA hsa-miR-374a-5p PPM1A 0.484615721953736 0.0042981729815149 -0.394847284284923 0.000386558346157747 mirMAP -0.116425194118682 0.000275790548225878 NA NA NA hsa-miR-484 PPM1A 1.81844463411787 1.82951571230938e-15 -0.394847284284923 0.000386558346157747 miRNAWalker2_validate -0.100919564857223 8.73686371580467e-06 NA NA NA hsa-let-7f-5p PPP3CA 0.495648727272215 0.00355972741198794 -0.281979431665802 0.0843014975757299 miRNATAP -0.145174821876866 0.00196996187493329 NA NA NA hsa-let-7g-5p PPP3CA 1.20061455355116 1.50237505511483e-12 -0.281979431665802 0.0843014975757299 miRNATAP -0.256650979931267 1.4045207283454e-08 NA NA NA hsa-miR-106a-5p PPP3CA 2.48882002962836 1.99757727374521e-12 -0.281979431665802 0.0843014975757299 miRNATAP -0.11191172835948 1.79556273427309e-07 NA NA NA hsa-miR-106b-5p PPP3CA 2.46782146831112 1.36171495805632e-23 -0.281979431665802 0.0843014975757299 miRNATAP -0.184105953911301 6.84398280050895e-10 NA NA NA hsa-miR-17-3p PPP3CA 2.2704817679209 1.1667437320211e-22 -0.281979431665802 0.0843014975757299 MirTarget -0.131133816129638 4.79999765543855e-05 NA NA NA hsa-miR-186-5p PPP3CA 1.47445398888668 3.0781726595413e-15 -0.281979431665802 0.0843014975757299 mirMAP -0.185694598107894 5.66511837519636e-06 NA NA NA hsa-miR-194-5p PPP3CA 1.8992998339217 3.76507853301977e-10 -0.281979431665802 0.0843014975757299 MirTarget -0.17070662815415 7.35898582017249e-12 NA NA NA hsa-miR-20a-5p PPP3CA 3.15577933619191 4.19753346442454e-25 -0.281979431665802 0.0843014975757299 miRNATAP -0.109419648077418 6.17460161232474e-06 NA NA NA hsa-miR-20b-5p PPP3CA 2.07706563022469 1.10107236083433e-05 -0.281979431665802 0.0843014975757299 miRNATAP -0.113387749946454 1.85473104688059e-12 NA NA NA hsa-miR-30c-5p PPP3CA 0.778774633108 0.000285599212429136 -0.281979431665802 0.0843014975757299 miRNATAP -0.212081199369466 4.85681407465908e-09 NA NA NA hsa-miR-30d-5p PPP3CA 0.675423997639582 0.00270618816039773 -0.281979431665802 0.0843014975757299 miRNATAP -0.142883121139453 4.34068465949306e-05 NA NA NA hsa-miR-501-3p PPP3CA 1.83132758513743 1.10971547702065e-10 -0.281979431665802 0.0843014975757299 MirTarget;PITA;miRNATAP -0.114452652427796 2.34298968304304e-05 NA NA NA hsa-miR-502-3p PPP3CA 1.50560877085049 1.2647489756373e-11 -0.281979431665802 0.0843014975757299 MirTarget;PITA;miRNATAP -0.15529134445823 7.08901270771209e-06 NA NA NA hsa-miR-664a-3p PPP3CA 0.634721925861133 0.00520070178640421 -0.281979431665802 0.0843014975757299 mirMAP -0.150747155909677 1.3336356409105e-05 NA NA NA hsa-miR-7-1-3p PPP3CA 1.84950311431067 1.25300363397654e-13 -0.281979431665802 0.0843014975757299 MirTarget;mirMAP -0.119727173710851 9.40140707131449e-05 NA NA NA hsa-miR-93-3p PPP3CA 2.85383869771942 5.64481766902125e-23 -0.281979431665802 0.0843014975757299 miRNATAP -0.152353546507485 2.15079066361371e-09 NA NA NA hsa-miR-93-5p PPP3CA 3.03961860136032 1.11672209617395e-24 -0.281979431665802 0.0843014975757299 miRNATAP -0.156066415468858 2.44288871078656e-10 NA NA NA hsa-miR-107 PPP3CB 1.30977326593435 1.30372468603965e-11 -1.03671584843429 6.12489584217064e-15 miRanda -0.224024061633064 1.13198598297881e-11 NA NA NA hsa-miR-15a-5p PPP3CB 2.34669284378787 1.69544424500258e-23 -1.03671584843429 6.12489584217064e-15 miRNATAP -0.188034579267018 6.2219880807044e-13 NA NA NA hsa-miR-15b-5p PPP3CB 1.57112623124278 9.14247846750597e-13 -1.03671584843429 6.12489584217064e-15 miRNATAP -0.245380830384666 5.15260568991425e-18 NA NA NA hsa-miR-16-5p PPP3CB 1.75824877145857 1.68592440033108e-16 -1.03671584843429 6.12489584217064e-15 miRNATAP -0.219222038672189 7.36535140884335e-14 NA NA NA hsa-miR-20a-3p PPP3CB 2.92621109947706 2.49504904635375e-17 -1.03671584843429 6.12489584217064e-15 miRNATAP -0.113868623377048 9.37084199962394e-10 NA NA NA hsa-miR-26b-5p PPP3CB 0.885393662798425 3.2116297961629e-06 -1.03671584843429 6.12489584217064e-15 MirTarget;miRNATAP -0.129362759155204 0.000196474595826764 NA NA NA hsa-miR-30c-5p PPP3CB 0.778774633108 0.000285599212429136 -1.03671584843429 6.12489584217064e-15 miRNATAP -0.165551300673001 5.92944884537219e-08 NA NA NA hsa-miR-30d-5p PPP3CB 0.675423997639582 0.00270618816039773 -1.03671584843429 6.12489584217064e-15 miRNATAP -0.128345099197797 1.20380214861929e-05 NA NA NA hsa-miR-320a PPP3CB 0.438165828017084 0.0390159073347133 -1.03671584843429 6.12489584217064e-15 miRanda -0.133683103961461 1.89473747516991e-05 NA NA NA hsa-miR-320b PPP3CB 1.55692969039548 1.41071034251915e-08 -1.03671584843429 6.12489584217064e-15 miRanda -0.157984627594008 1.12882018634839e-11 NA NA NA hsa-miR-330-5p PPP3CB 1.15100069700871 4.85551805046014e-07 -1.03671584843429 6.12489584217064e-15 MirTarget;PITA;miRanda -0.122279132326624 1.90117350044819e-05 NA NA NA hsa-miR-339-5p PPP3CB 2.68710938429893 3.03134080808154e-16 -1.03671584843429 6.12489584217064e-15 miRanda -0.129274316344838 1.00359131009696e-11 NA NA NA hsa-miR-361-5p PPP3CB 0.971859117235239 5.30236555707088e-09 -1.03671584843429 6.12489584217064e-15 miRanda -0.319599472524393 7.32960352437588e-17 NA NA NA hsa-miR-421 PPP3CB 1.17791565395543 6.78526676976629e-06 -1.03671584843429 6.12489584217064e-15 miRanda -0.107753543524587 1.70411972807069e-05 NA NA NA hsa-miR-429 PPP3CB 4.48815175680773 2.44117492218206e-17 -1.03671584843429 6.12489584217064e-15 miRanda -0.104170748345545 1.10824048087982e-19 NA NA NA hsa-miR-501-5p PPP3CB 1.93654809410041 1.3779381780759e-10 -1.03671584843429 6.12489584217064e-15 PITA;miRNATAP -0.110941325807012 4.19796167603695e-07 NA NA NA hsa-miR-590-3p PPP3CB 2.59289455139753 1.03200520972022e-21 -1.03671584843429 6.12489584217064e-15 miRanda -0.160737546369274 6.57567642585996e-12 NA NA NA hsa-miR-7-1-3p PPP3CB 1.84950311431067 1.25300363397654e-13 -1.03671584843429 6.12489584217064e-15 mirMAP -0.170702158890249 1.5272735318301e-11 NA NA NA hsa-miR-361-5p PPP3CC 0.971859117235239 5.30236555707088e-09 -0.895441456978914 1.07671854464434e-07 miRanda -0.275565592476708 1.65394541713718e-08 NA NA NA hsa-miR-500a-3p PPP3CC 1.47161373123699 5.30571342631915e-09 -0.895441456978914 1.07671854464434e-07 MirTarget;miRNATAP -0.11299814981742 0.000453955248711429 NA NA NA hsa-miR-502-3p PPP3CC 1.50560877085049 1.2647489756373e-11 -0.895441456978914 1.07671854464434e-07 MirTarget;PITA;miRNATAP -0.137316418088144 0.000157963764790067 NA NA NA hsa-miR-101-3p PPP3R1 0.522819989585461 0.00375627731618038 -0.0284423401171923 0.760566460331176 miRNATAP -0.130896280595902 1.18496266678438e-07 NA NA NA hsa-let-7a-3p PRKACB 1.42015538786275 7.03375209382654e-13 -1.11910356116881 7.24897707751757e-07 MirTarget;mirMAP;miRNATAP -0.21962130459547 5.79651670137419e-05 NA NA NA hsa-let-7b-3p PRKACB 0.868207752019623 1.30460056774366e-05 -1.11910356116881 7.24897707751757e-07 MirTarget;mirMAP;miRNATAP -0.185130585565506 0.000844018426388941 NA NA NA hsa-let-7d-3p PRKACB 0.837345596411224 1.39469480391458e-05 -1.11910356116881 7.24897707751757e-07 MirTarget -0.193122206370836 0.000761987397647901 NA NA NA hsa-let-7f-1-3p PRKACB 1.55054488387679 7.31326775537952e-11 -1.11910356116881 7.24897707751757e-07 MirTarget;mirMAP -0.13342047017702 0.00451064067873152 NA NA NA hsa-miR-126-5p PRKACB 0.895338176458417 2.33372756450713e-05 -1.11910356116881 7.24897707751757e-07 mirMAP -0.171245788041164 0.00102349617124601 NA NA NA hsa-miR-141-3p PRKACB 5.02396127982626 2.19224509139725e-24 -1.11910356116881 7.24897707751757e-07 MirTarget;TargetScan;miRNATAP -0.131248917259806 2.40182503281301e-10 NA NA NA hsa-miR-16-2-3p PRKACB 2.31623086727196 4.29838149388188e-20 -1.11910356116881 7.24897707751757e-07 mirMAP -0.211513116774948 3.56654687944943e-07 NA NA NA hsa-miR-17-5p PRKACB 3.2710598467455 9.93128340539455e-27 -1.11910356116881 7.24897707751757e-07 TargetScan -0.195594044734934 5.04690942157379e-09 NA NA NA hsa-miR-182-5p PRKACB 3.53923166221814 5.07781258121574e-21 -1.11910356116881 7.24897707751757e-07 MirTarget;miRNATAP -0.141282769334308 3.27226662914892e-07 NA NA NA hsa-miR-183-5p PRKACB 4.19757025992371 4.79612296318304e-26 -1.11910356116881 7.24897707751757e-07 MirTarget -0.132170429294976 3.08274590025093e-07 NA NA NA hsa-miR-18a-5p PRKACB 3.78535678765353 3.72446596213886e-26 -1.11910356116881 7.24897707751757e-07 miRNATAP -0.170312158994311 1.8268780409686e-08 NA NA NA hsa-miR-193a-3p PRKACB 1.60460546928078 2.86169793322984e-07 -1.11910356116881 7.24897707751757e-07 miRanda -0.185097829574766 8.14913568795542e-08 NA NA NA hsa-miR-19a-3p PRKACB 3.42309334186656 3.02671914353412e-28 -1.11910356116881 7.24897707751757e-07 MirTarget;miRNATAP -0.217127685863828 2.72225260525319e-11 NA NA NA hsa-miR-19b-3p PRKACB 2.49529833021187 1.57028265846699e-23 -1.11910356116881 7.24897707751757e-07 miRNAWalker2_validate;MirTarget;miRNATAP -0.267352556269149 9.00420806048956e-11 NA NA NA hsa-miR-200c-3p PRKACB 3.50132673580082 2.42716349086937e-15 -1.11910356116881 7.24897707751757e-07 MirTarget;miRNATAP -0.125201076382777 1.50017445380767e-07 NA NA NA hsa-miR-2110 PRKACB 1.16625590651194 6.4784195289885e-05 -1.11910356116881 7.24897707751757e-07 MirTarget -0.106141262528439 0.00882154187258127 NA NA NA hsa-miR-3065-5p PRKACB 2.74629919868982 1.86846589298284e-08 -1.11910356116881 7.24897707751757e-07 MirTarget -0.103807774563958 0.000132862723321062 NA NA NA hsa-miR-30d-3p PRKACB 0.977747550180601 4.3048212205381e-05 -1.11910356116881 7.24897707751757e-07 mirMAP -0.230639716646997 4.57613056559806e-07 NA NA NA hsa-miR-32-3p PRKACB 2.02436999565685 5.94091197945307e-09 -1.11910356116881 7.24897707751757e-07 mirMAP;miRNATAP -0.100714992594509 0.00471640544853458 NA NA NA hsa-miR-339-5p PRKACB 2.68710938429893 3.03134080808154e-16 -1.11910356116881 7.24897707751757e-07 miRanda -0.145165623596419 6.50854523117634e-06 NA NA NA hsa-miR-34a-5p PRKACB 1.9016323452565 1.43092834643601e-14 -1.11910356116881 7.24897707751757e-07 miRNATAP -0.238915288481547 2.59419071561778e-08 NA NA NA hsa-miR-361-5p PRKACB 0.971859117235239 5.30236555707088e-09 -1.11910356116881 7.24897707751757e-07 miRanda -0.178114095699739 0.00724869450353386 NA NA NA hsa-miR-362-3p PRKACB 2.0756816987665 3.89026064579331e-12 -1.11910356116881 7.24897707751757e-07 PITA;miRanda;miRNATAP -0.2320492729467 2.29661541166603e-10 NA NA NA hsa-miR-362-5p PRKACB 1.59303749908759 9.582675908797e-08 -1.11910356116881 7.24897707751757e-07 PITA -0.194987590184185 6.59081906609811e-08 NA NA NA hsa-miR-3653-3p PRKACB 1.85886928622326 2.98407490336841e-08 -1.11910356116881 7.24897707751757e-07 MirTarget -0.105612181380441 0.00210192398606289 NA NA NA hsa-miR-532-5p PRKACB 1.55697650978597 1.57884735535196e-11 -1.11910356116881 7.24897707751757e-07 PITA -0.27784223940084 1.83614058183971e-09 NA NA NA hsa-miR-590-3p PRKACB 2.59289455139753 1.03200520972022e-21 -1.11910356116881 7.24897707751757e-07 MirTarget;PITA;miRanda;miRNATAP -0.20137371596257 3.58630956215221e-07 NA NA NA hsa-miR-590-5p PRKACB 3.18300989862077 2.06813568597893e-26 -1.11910356116881 7.24897707751757e-07 miRanda -0.22361088291547 1.69108646897883e-10 NA NA NA hsa-miR-7-1-3p PRKACB 1.84950311431067 1.25300363397654e-13 -1.11910356116881 7.24897707751757e-07 mirMAP -0.160819398581311 0.000186176032630634 NA NA NA hsa-miR-708-3p PRKACB 2.80907765282502 3.07460722669281e-14 -1.11910356116881 7.24897707751757e-07 mirMAP -0.107628106192083 0.000190951072862047 NA NA NA hsa-miR-93-5p PRKACB 3.03961860136032 1.11672209617395e-24 -1.11910356116881 7.24897707751757e-07 miRNAWalker2_validate -0.194608106414379 2.15593790853491e-08 NA NA NA hsa-miR-96-5p PRKACB 4.89433085814374 1.92000659886961e-31 -1.11910356116881 7.24897707751757e-07 miRNATAP -0.144257226112366 5.04306410867738e-09 NA NA NA hsa-miR-142-5p PRKCA 1.17581605694506 0.0018174701991234 -1.04253532292201 0.000330447904822586 mirMAP -0.155281859758494 2.83714874751982e-05 NA NA NA hsa-miR-146a-5p PRKCA 1.19829319599115 0.00157081974524452 -1.04253532292201 0.000330447904822586 mirMAP -0.131710886401928 0.000370553312736514 NA NA NA hsa-miR-146b-5p PRKCA 1.75587235896724 1.15724631266659e-07 -1.04253532292201 0.000330447904822586 mirMAP -0.178218054737334 2.01234944480139e-05 NA NA NA hsa-miR-150-5p PRKCA -0.105827294491332 0.799351458244375 -1.04253532292201 0.000330447904822586 mirMAP -0.124697814540873 0.00022848052592286 NA NA NA hsa-miR-17-3p PRKCA 2.2704817679209 1.1667437320211e-22 -1.04253532292201 0.000330447904822586 miRNAWalker2_validate -0.163389027302081 0.00492702694664717 NA NA NA hsa-miR-181a-5p PRKCA 2.29556023480783 1.8138457900616e-21 -1.04253532292201 0.000330447904822586 mirMAP -0.332076264197257 1.58885695452918e-09 NA NA NA hsa-miR-181b-5p PRKCA 2.49307679431293 3.92829250217627e-20 -1.04253532292201 0.000330447904822586 mirMAP -0.255352495229191 2.20407502467148e-07 NA NA NA hsa-miR-181c-5p PRKCA 1.58587920618301 1.57506918816933e-10 -1.04253532292201 0.000330447904822586 mirMAP -0.187181736198993 0.000814130560426752 NA NA NA hsa-miR-183-5p PRKCA 4.19757025992371 4.79612296318304e-26 -1.04253532292201 0.000330447904822586 miRNATAP -0.167765439348368 3.7027196892035e-07 NA NA NA hsa-miR-186-5p PRKCA 1.47445398888668 3.0781726595413e-15 -1.04253532292201 0.000330447904822586 miRNATAP -0.372737117584225 3.41129073481267e-07 NA NA NA hsa-miR-193b-3p PRKCA 2.25711804611899 4.1940744806631e-14 -1.04253532292201 0.000330447904822586 miRNAWalker2_validate -0.184015097403191 5.6276271806172e-05 NA NA NA hsa-miR-193b-5p PRKCA 1.59567208918739 4.89398272459427e-08 -1.04253532292201 0.000330447904822586 mirMAP -0.144499830970602 0.00240910945358069 NA NA NA hsa-miR-1976 PRKCA 2.06550563678192 7.81396978619772e-18 -1.04253532292201 0.000330447904822586 miRNATAP -0.17995688234711 0.00150164194068263 NA NA NA hsa-miR-19b-1-5p PRKCA 2.57951428759379 4.31576118703427e-20 -1.04253532292201 0.000330447904822586 mirMAP -0.172921934994649 0.000451924002079924 NA NA NA hsa-miR-200b-3p PRKCA 3.78235093249346 3.18343003239465e-14 -1.04253532292201 0.000330447904822586 TargetScan -0.114961109829389 2.45352651543255e-05 NA NA NA hsa-miR-200c-3p PRKCA 3.50132673580082 2.42716349086937e-15 -1.04253532292201 0.000330447904822586 miRNATAP -0.158977004957444 1.80034178057763e-07 NA NA NA hsa-miR-214-3p PRKCA -0.176344800034733 0.642485503428886 -1.04253532292201 0.000330447904822586 mirMAP -0.126245731078837 0.000711043186976772 NA NA NA hsa-miR-22-5p PRKCA 1.88011544159252 1.63978222572222e-16 -1.04253532292201 0.000330447904822586 mirMAP -0.258621101167742 1.45994385651039e-05 NA NA NA hsa-miR-24-2-5p PRKCA 2.07171035460647 3.15853539996136e-16 -1.04253532292201 0.000330447904822586 miRNAWalker2_validate -0.190869345201713 0.000384051796932142 22911661 Preferential star strand biogenesis of pre miR 24 2 targets PKC alpha and suppresses cell survival in MCF 7 breast cancer cells poor survival breast cancer hsa-miR-339-5p PRKCA 2.68710938429893 3.03134080808154e-16 -1.04253532292201 0.000330447904822586 mirMAP -0.146901538113986 0.000377758588526939 NA NA NA hsa-miR-3607-3p PRKCA 2.68532138541128 5.66716351955047e-14 -1.04253532292201 0.000330447904822586 mirMAP -0.141547181715678 0.000312501141538225 NA NA NA hsa-miR-362-5p PRKCA 1.59303749908759 9.582675908797e-08 -1.04253532292201 0.000330447904822586 TargetScan;miRNATAP -0.155938176693359 0.000821123203239911 NA NA NA hsa-miR-369-3p PRKCA 0.946781510019564 0.00134850306966842 -1.04253532292201 0.000330447904822586 PITA;miRNATAP -0.153415665611504 0.0013232753592926 NA NA NA hsa-miR-381-3p PRKCA -0.0821432056113931 0.752465205603634 -1.04253532292201 0.000330447904822586 mirMAP -0.182718955463403 0.000792478176257635 NA NA NA hsa-miR-429 PRKCA 4.48815175680773 2.44117492218206e-17 -1.04253532292201 0.000330447904822586 miRanda;miRNATAP -0.108496235247986 1.950717922572e-05 NA NA NA hsa-miR-450b-5p PRKCA 1.69244418548325 1.68064054148881e-10 -1.04253532292201 0.000330447904822586 PITA;mirMAP;miRNATAP -0.164559118659435 0.00164963824183995 NA NA NA hsa-miR-500a-5p PRKCA 1.72110365584658 3.0807246212659e-10 -1.04253532292201 0.000330447904822586 miRNATAP -0.224298470556856 8.73025451195054e-06 NA NA NA hsa-miR-501-5p PRKCA 1.93654809410041 1.3779381780759e-10 -1.04253532292201 0.000330447904822586 miRNATAP -0.160491119587112 0.000665161220237392 NA NA NA hsa-miR-505-3p PRKCA 1.45322244209148 8.86597629645867e-10 -1.04253532292201 0.000330447904822586 miRNAWalker2_validate -0.17319300539973 0.00317185860747904 NA NA NA hsa-miR-505-5p PRKCA 1.89243395287645 9.82003586561819e-12 -1.04253532292201 0.000330447904822586 mirMAP -0.170760296141889 0.000583545058780229 NA NA NA hsa-miR-532-3p PRKCA 1.96631878320218 4.53421954361695e-13 -1.04253532292201 0.000330447904822586 mirMAP;miRNATAP -0.153994961004655 0.00236643084778704 NA NA NA hsa-miR-590-3p PRKCA 2.59289455139753 1.03200520972022e-21 -1.04253532292201 0.000330447904822586 PITA;miRanda;mirMAP;miRNATAP -0.257692443896068 3.43649017566933e-07 NA NA NA hsa-miR-92a-3p PRKCA 2.06460102658973 1.44784291084757e-19 -1.04253532292201 0.000330447904822586 miRNAWalker2_validate -0.177264968474978 0.0028853007950597 NA NA NA hsa-miR-93-3p PRKCA 2.85383869771942 5.64481766902125e-23 -1.04253532292201 0.000330447904822586 mirMAP -0.164593044407034 0.000371570157401047 NA NA NA hsa-miR-129-5p PRKCB -0.524170159980738 0.222582956006346 -3.26032077132529 1.38524824909011e-12 miRanda;mirMAP -0.174875281711081 0.00126377112961492 NA NA NA hsa-miR-141-5p PRKCB 3.81419396518882 3.21977359736126e-18 -3.26032077132529 1.38524824909011e-12 mirMAP -0.448157631252767 6.03056466923945e-21 NA NA NA hsa-miR-16-2-3p PRKCB 2.31623086727196 4.29838149388188e-20 -3.26032077132529 1.38524824909011e-12 mirMAP -0.508156111029493 2.858696818642e-09 NA NA NA hsa-miR-186-5p PRKCB 1.47445398888668 3.0781726595413e-15 -3.26032077132529 1.38524824909011e-12 mirMAP -0.79180135498475 1.36020814670637e-11 NA NA NA hsa-miR-194-5p PRKCB 1.8992998339217 3.76507853301977e-10 -3.26032077132529 1.38524824909011e-12 miRNATAP -0.485081827287577 2.16525492854143e-11 NA NA NA hsa-miR-200b-3p PRKCB 3.78235093249346 3.18343003239465e-14 -3.26032077132529 1.38524824909011e-12 MirTarget -0.450279840251611 3.58923445938153e-27 NA NA NA hsa-miR-200c-3p PRKCB 3.50132673580082 2.42716349086937e-15 -3.26032077132529 1.38524824909011e-12 MirTarget;miRNATAP -0.48715771688849 5.01263551249731e-25 NA NA NA hsa-miR-23a-3p PRKCB 1.00493340843378 2.55313889288924e-08 -3.26032077132529 1.38524824909011e-12 mirMAP -0.422834753714352 0.000810959402297788 NA NA NA hsa-miR-24-3p PRKCB 0.99989036772428 1.35595013650376e-07 -3.26032077132529 1.38524824909011e-12 miRNATAP -0.496540154032259 3.34685620532722e-05 NA NA NA hsa-miR-26b-5p PRKCB 0.885393662798425 3.2116297961629e-06 -3.26032077132529 1.38524824909011e-12 mirMAP -0.316938073060502 0.0085744560045255 NA NA NA hsa-miR-29b-2-5p PRKCB 0.910668640983475 0.00666655585493488 -3.26032077132529 1.38524824909011e-12 mirMAP -0.34510237827648 3.08410596869229e-07 NA NA NA hsa-miR-30b-5p PRKCB 0.800822374912712 0.000133601914525413 -3.26032077132529 1.38524824909011e-12 mirMAP -0.425134820547528 9.53655468608799e-05 NA NA NA hsa-miR-30c-5p PRKCB 0.778774633108 0.000285599212429136 -3.26032077132529 1.38524824909011e-12 mirMAP -0.468954366973799 1.00031056614682e-05 NA NA NA hsa-miR-30d-3p PRKCB 0.977747550180601 4.3048212205381e-05 -3.26032077132529 1.38524824909011e-12 mirMAP -0.529262539307465 2.03079793114812e-08 NA NA NA hsa-miR-30d-5p PRKCB 0.675423997639582 0.00270618816039773 -3.26032077132529 1.38524824909011e-12 mirMAP -0.603674275615055 1.78624617709124e-09 NA NA NA hsa-miR-330-5p PRKCB 1.15100069700871 4.85551805046014e-07 -3.26032077132529 1.38524824909011e-12 miRanda -0.265696306996962 0.00757029049385514 NA NA NA hsa-miR-335-3p PRKCB 3.08791651139852 5.31309869723517e-12 -3.26032077132529 1.38524824909011e-12 mirMAP -0.330098295724148 1.15037296640229e-11 NA NA NA hsa-miR-335-5p PRKCB 1.77247705492746 2.22457658872091e-06 -3.26032077132529 1.38524824909011e-12 mirMAP -0.231797522536577 0.000116559468268159 NA NA NA hsa-miR-3607-3p PRKCB 2.68532138541128 5.66716351955047e-14 -3.26032077132529 1.38524824909011e-12 miRNATAP -0.309871089079837 9.51108883796167e-07 NA NA NA hsa-miR-361-5p PRKCB 0.971859117235239 5.30236555707088e-09 -3.26032077132529 1.38524824909011e-12 MirTarget;miRanda;miRNATAP -1.08630383105364 2.58179254217249e-16 NA NA NA hsa-miR-429 PRKCB 4.48815175680773 2.44117492218206e-17 -3.26032077132529 1.38524824909011e-12 MirTarget;miRanda;miRNATAP -0.42521096062837 6.46582126393278e-28 NA NA NA hsa-miR-450b-5p PRKCB 1.69244418548325 1.68064054148881e-10 -3.26032077132529 1.38524824909011e-12 miRNATAP -0.300053601902219 0.00039020696289519 NA NA NA hsa-miR-452-3p PRKCB 2.42521958420768 4.08754552781156e-07 -3.26032077132529 1.38524824909011e-12 mirMAP -0.174939955360914 0.000207028768427815 NA NA NA hsa-miR-484 PRKCB 1.81844463411787 1.82951571230938e-15 -3.26032077132529 1.38524824909011e-12 MirTarget;miRNATAP -0.703163397284051 1.07982697132474e-13 NA NA NA hsa-miR-491-5p PRKCB 0.615770352820862 0.0418295628761654 -3.26032077132529 1.38524824909011e-12 miRanda -0.381404660757775 2.20068611106109e-06 NA NA NA hsa-miR-589-3p PRKCB 2.51971841868825 2.39125940264107e-11 -3.26032077132529 1.38524824909011e-12 mirMAP -0.452218517865859 7.06052991667871e-12 NA NA NA hsa-miR-589-5p PRKCB 1.71990116752371 8.310889042056e-14 -3.26032077132529 1.38524824909011e-12 mirMAP -0.544486942502154 1.22125132593852e-08 NA NA NA hsa-miR-590-3p PRKCB 2.59289455139753 1.03200520972022e-21 -3.26032077132529 1.38524824909011e-12 mirMAP -0.388404821887359 2.22817064825303e-06 NA NA NA hsa-miR-590-5p PRKCB 3.18300989862077 2.06813568597893e-26 -3.26032077132529 1.38524824909011e-12 miRanda -0.553979313426607 1.10231423603006e-14 NA NA NA hsa-miR-7-1-3p PRKCB 1.84950311431067 1.25300363397654e-13 -3.26032077132529 1.38524824909011e-12 mirMAP -0.468511892026853 1.14425525890782e-07 NA NA NA hsa-miR-7-5p PRKCB 2.28980165299999 1.5131097560452e-07 -3.26032077132529 1.38524824909011e-12 MirTarget;miRNATAP -0.171892302839442 0.00201428643670522 NA NA NA hsa-miR-944 PRKCB 2.91186649218281 1.31574753528144e-06 -3.26032077132529 1.38524824909011e-12 mirMAP -0.173419280691746 6.46731956750453e-06 NA NA NA hsa-let-7g-3p PTPN5 3.26398061402445 3.96263126107645e-25 -1.66770458890508 0.000678949052449137 MirTarget -0.537789717555005 4.65217094549626e-14 NA NA NA hsa-miR-128-3p PTPN5 1.63756041666078 6.79626586407187e-14 -1.66770458890508 0.000678949052449137 MirTarget -0.491452489145822 3.42502836149422e-06 NA NA NA hsa-miR-144-3p PTPN5 0.658119849508907 0.146943823997989 -1.66770458890508 0.000678949052449137 miRNATAP -0.161180076845923 0.00296192965970391 NA NA NA hsa-miR-330-5p PTPN5 1.15100069700871 4.85551805046014e-07 -1.66770458890508 0.000678949052449137 miRanda -0.494279981805842 1.51613618964279e-06 NA NA NA hsa-miR-429 PTPN5 4.48815175680773 2.44117492218206e-17 -1.66770458890508 0.000678949052449137 miRanda -0.2511684789396 3.47712640175414e-09 NA NA NA hsa-miR-744-3p PTPN5 2.7517405670917 4.22040908411227e-14 -1.66770458890508 0.000678949052449137 MirTarget -0.459501034038899 1.00875566177259e-13 NA NA NA hsa-miR-940 PTPN5 3.21011374578759 2.7923171128495e-14 -1.66770458890508 0.000678949052449137 miRNATAP -0.360368570231897 8.69168801299338e-10 NA NA NA hsa-miR-10b-3p PTPN7 0.77597971642517 0.00264877454133753 -0.306177995364629 0.485362950469759 MirTarget -0.317022729428456 0.000107699865368638 NA NA NA hsa-miR-331-3p PTPN7 2.28379581858927 1.99663919173155e-18 -0.306177995364629 0.485362950469759 MirTarget -0.468992260784253 1.05935865547261e-09 NA NA NA hsa-miR-335-5p PTPN7 1.77247705492746 2.22457658872091e-06 -0.306177995364629 0.485362950469759 miRNAWalker2_validate -0.170258572287091 0.002324439817221 NA NA NA hsa-miR-425-5p PTPN7 3.07071373939774 4.02947460586085e-25 -0.306177995364629 0.485362950469759 MirTarget -0.27929406271086 3.14412800230957e-05 NA NA NA hsa-miR-484 PTPN7 1.81844463411787 1.82951571230938e-15 -0.306177995364629 0.485362950469759 mirMAP -0.302077419683276 0.000783423345400774 NA NA NA hsa-miR-150-5p PTPRR -0.105827294491332 0.799351458244375 1.7591256704943 0.0121053826049444 miRNAWalker2_validate -0.247935101704252 0.00239620904249678 NA NA NA hsa-miR-338-3p PTPRR 0.453166438193782 0.144583389707558 1.7591256704943 0.0121053826049444 miRanda -0.331156160103156 0.00252200246638463 NA NA NA hsa-miR-374b-5p RAC1 0.0654362503857184 0.722673188879465 0.221936454340431 0.051549220692643 mirMAP -0.101573831955509 0.000746852128506454 NA NA NA hsa-miR-375 RAC2 1.13910305294079 0.0512283522214186 0.0225400305534329 0.947191555182511 miRanda -0.111974015284125 5.98476138848745e-05 NA NA NA hsa-let-7a-3p RAP1A 1.42015538786275 7.03375209382654e-13 -1.0434884652411 1.94863584356979e-14 mirMAP -0.224724794924004 8.95540940127091e-12 NA NA NA hsa-let-7b-3p RAP1A 0.868207752019623 1.30460056774366e-05 -1.0434884652411 1.94863584356979e-14 mirMAP -0.101197716480348 0.0029967877921152 NA NA NA hsa-miR-101-5p RAP1A 0.782067874775122 0.00443725251526842 -1.0434884652411 1.94863584356979e-14 MirTarget -0.13103442258546 1.91947268044239e-07 NA NA NA hsa-miR-125a-5p RAP1A 0.599529391575274 0.0102300147180307 -1.0434884652411 1.94863584356979e-14 miRanda -0.120822313738346 3.16483745923974e-05 NA NA NA hsa-miR-149-5p RAP1A 2.94200492826326 4.93436498919036e-14 -1.0434884652411 1.94863584356979e-14 MirTarget;miRNATAP -0.106140260829361 1.27806775160534e-10 NA NA NA hsa-miR-16-1-3p RAP1A 2.56983217111073 3.02262181237943e-20 -1.0434884652411 1.94863584356979e-14 MirTarget -0.196961148602664 1.22905853869133e-17 NA NA NA hsa-miR-16-2-3p RAP1A 2.31623086727196 4.29838149388188e-20 -1.0434884652411 1.94863584356979e-14 MirTarget;mirMAP -0.173549845840885 5.56374526112486e-12 NA NA NA hsa-miR-186-5p RAP1A 1.47445398888668 3.0781726595413e-15 -1.0434884652411 1.94863584356979e-14 mirMAP -0.204598710416168 4.80532165007133e-09 NA NA NA hsa-miR-19a-3p RAP1A 3.42309334186656 3.02671914353412e-28 -1.0434884652411 1.94863584356979e-14 MirTarget;miRNATAP -0.16815717960042 1.30227368899674e-17 NA NA NA hsa-miR-19b-3p RAP1A 2.49529833021187 1.57028265846699e-23 -1.0434884652411 1.94863584356979e-14 MirTarget;miRNATAP -0.215451937444313 4.11793601184036e-18 NA NA NA hsa-miR-25-3p RAP1A 1.36472605225697 4.83790725935681e-11 -1.0434884652411 1.94863584356979e-14 mirMAP -0.230057213097495 2.26977159326414e-13 NA NA NA hsa-miR-26a-2-3p RAP1A 0.823520019989974 0.00017092160823769 -1.0434884652411 1.94863584356979e-14 MirTarget -0.138689266178359 7.61798152695236e-06 NA NA NA hsa-miR-26b-5p RAP1A 0.885393662798425 3.2116297961629e-06 -1.0434884652411 1.94863584356979e-14 MirTarget;miRNATAP -0.163040362705406 4.24517403285822e-06 NA NA NA hsa-miR-32-5p RAP1A 2.34056473219422 6.24134585974322e-20 -1.0434884652411 1.94863584356979e-14 mirMAP;miRNATAP -0.190660947454226 1.01725447373065e-14 NA NA NA hsa-miR-320a RAP1A 0.438165828017084 0.0390159073347133 -1.0434884652411 1.94863584356979e-14 MirTarget;PITA;miRanda;miRNATAP -0.21602759664377 6.95103599006302e-12 NA NA NA hsa-miR-320b RAP1A 1.55692969039548 1.41071034251915e-08 -1.0434884652411 1.94863584356979e-14 MirTarget;PITA;miRanda;miRNATAP -0.16423312802573 5.48401921536116e-12 NA NA NA hsa-miR-324-5p RAP1A 2.95683728155095 1.32960514360912e-20 -1.0434884652411 1.94863584356979e-14 miRanda -0.153641776425352 7.54744772252417e-15 NA NA NA hsa-miR-362-3p RAP1A 2.0756816987665 3.89026064579331e-12 -1.0434884652411 1.94863584356979e-14 miRanda -0.11220810269389 7.49219849039476e-07 NA NA NA hsa-miR-3913-5p RAP1A 2.44353493655328 8.95279496632448e-15 -1.0434884652411 1.94863584356979e-14 mirMAP -0.191495114855697 1.03372355391545e-20 NA NA NA hsa-miR-429 RAP1A 4.48815175680773 2.44117492218206e-17 -1.0434884652411 1.94863584356979e-14 miRanda -0.119129230968671 1.02711682003224e-24 NA NA NA hsa-miR-501-3p RAP1A 1.83132758513743 1.10971547702065e-10 -1.0434884652411 1.94863584356979e-14 TargetScan;miRNATAP -0.113815693051489 9.49341834246497e-07 NA NA NA hsa-miR-590-3p RAP1A 2.59289455139753 1.03200520972022e-21 -1.0434884652411 1.94863584356979e-14 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.141676976493134 4.57436054034706e-09 NA NA NA hsa-miR-590-5p RAP1A 3.18300989862077 2.06813568597893e-26 -1.0434884652411 1.94863584356979e-14 miRanda -0.15348101987022 6.65517116991475e-13 NA NA NA hsa-miR-625-3p RAP1A 1.18769734290812 2.47200238827911e-06 -1.0434884652411 1.94863584356979e-14 mirMAP -0.112213454103308 2.43830810284901e-05 NA NA NA hsa-miR-660-5p RAP1A 1.82692095272076 1.92040083607196e-13 -1.0434884652411 1.94863584356979e-14 MirTarget;miRNATAP -0.170753703159053 6.16218370126605e-11 NA NA NA hsa-miR-664a-3p RAP1A 0.634721925861133 0.00520070178640421 -1.0434884652411 1.94863584356979e-14 mirMAP -0.189816392665286 1.09988671069259e-10 NA NA NA hsa-miR-7-1-3p RAP1A 1.84950311431067 1.25300363397654e-13 -1.0434884652411 1.94863584356979e-14 mirMAP -0.149042260688725 1.17362806253114e-08 NA NA NA hsa-miR-877-5p RAP1A 2.94916202082736 1.8151927276044e-13 -1.0434884652411 1.94863584356979e-14 mirMAP -0.111721180135264 8.82048176615582e-10 NA NA NA hsa-miR-92a-3p RAP1A 2.06460102658973 1.44784291084757e-19 -1.0434884652411 1.94863584356979e-14 mirMAP;miRNATAP -0.223541569866338 6.32044230210158e-16 NA NA NA hsa-miR-127-5p RAPGEF2 1.19850695520181 4.10976607177645e-05 -0.523133971893087 0.000808633238641125 MirTarget;PITA;miRNATAP -0.106428292527708 3.25324281744357e-05 NA NA NA hsa-miR-155-5p RAPGEF2 1.20164021433135 0.00086170622431261 -0.523133971893087 0.000808633238641125 miRNAWalker2_validate;MirTarget -0.14507831307013 1.07612712759592e-12 NA NA NA hsa-miR-193a-3p RAPGEF2 1.60460546928078 2.86169793322984e-07 -0.523133971893087 0.000808633238641125 miRanda -0.118198300083844 6.00198875343166e-07 NA NA NA hsa-miR-19a-3p RAPGEF2 3.42309334186656 3.02671914353412e-28 -0.523133971893087 0.000808633238641125 MirTarget;miRNATAP -0.117658574476224 1.79851464668763e-07 NA NA NA hsa-miR-19b-3p RAPGEF2 2.49529833021187 1.57028265846699e-23 -0.523133971893087 0.000808633238641125 MirTarget;miRNATAP -0.141795598597451 6.66219294992226e-07 NA NA NA hsa-miR-27a-3p RAPGEF2 1.66542180327138 4.93775737894805e-13 -0.523133971893087 0.000808633238641125 MirTarget;miRNATAP -0.135025587199448 2.35752076145205e-05 NA NA NA hsa-miR-339-5p RAPGEF2 2.68710938429893 3.03134080808154e-16 -0.523133971893087 0.000808633238641125 MirTarget;PITA -0.10580749874606 1.52471667392419e-06 NA NA NA hsa-miR-369-3p RAPGEF2 0.946781510019564 0.00134850306966842 -0.523133971893087 0.000808633238641125 MirTarget;PITA;miRNATAP -0.100567200656152 8.15309617582138e-05 NA NA NA hsa-miR-511-5p RAPGEF2 1.04499312543772 0.00234126154508174 -0.523133971893087 0.000808633238641125 MirTarget -0.108689689422386 6.04396905387887e-07 NA NA NA hsa-miR-590-3p RAPGEF2 2.59289455139753 1.03200520972022e-21 -0.523133971893087 0.000808633238641125 miRanda -0.116957475239568 1.71911511996314e-05 NA NA NA hsa-miR-30c-5p RASA1 0.778774633108 0.000285599212429136 -0.0207024925540615 0.910533635152395 miRNAWalker2_validate;MirTarget;miRNATAP -0.14388971632777 0.000504818574153645 NA NA NA hsa-miR-320a RASA1 0.438165828017084 0.0390159073347133 -0.0207024925540615 0.910533635152395 MirTarget;PITA;miRanda;miRNATAP -0.156593432428182 0.000194139100509342 NA NA NA hsa-miR-29b-2-5p RASGRF1 0.910668640983475 0.00666655585493488 1.27370554930097 0.01316303188544 mirMAP -0.253288449141953 0.000619811640224574 NA NA NA hsa-miR-320a RASGRF1 0.438165828017084 0.0390159073347133 1.27370554930097 0.01316303188544 miRanda -0.374514134461256 0.0015229444580916 NA NA NA hsa-let-7a-3p RASGRF2 1.42015538786275 7.03375209382654e-13 -0.959101466033611 0.00295453490406439 mirMAP -0.354340266719315 4.37397814040873e-06 NA NA NA hsa-miR-103a-2-5p RASGRF2 2.47599305985086 7.933028987326e-11 -0.959101466033611 0.00295453490406439 mirMAP -0.303701392890361 8.83465131281723e-12 NA NA NA hsa-miR-106a-5p RASGRF2 2.48882002962836 1.99757727374521e-12 -0.959101466033611 0.00295453490406439 MirTarget -0.253504555445005 2.23776501835649e-09 NA NA NA hsa-miR-106b-5p RASGRF2 2.46782146831112 1.36171495805632e-23 -0.959101466033611 0.00295453490406439 MirTarget -0.489650883516531 3.88966956864674e-17 NA NA NA hsa-miR-1266-5p RASGRF2 1.3763848124288 0.000876906064212958 -0.959101466033611 0.00295453490406439 MirTarget -0.160320352078417 2.05739533143518e-05 NA NA NA hsa-miR-129-5p RASGRF2 -0.524170159980738 0.222582956006346 -0.959101466033611 0.00295453490406439 mirMAP -0.129844885064158 0.000460642814601332 NA NA NA hsa-miR-144-3p RASGRF2 0.658119849508907 0.146943823997989 -0.959101466033611 0.00295453490406439 MirTarget -0.103815914082991 0.00353526087266036 NA NA NA hsa-miR-17-5p RASGRF2 3.2710598467455 9.93128340539455e-27 -0.959101466033611 0.00295453490406439 MirTarget;TargetScan -0.388507484141023 5.81881938546046e-17 NA NA NA hsa-miR-182-5p RASGRF2 3.53923166221814 5.07781258121574e-21 -0.959101466033611 0.00295453490406439 mirMAP -0.280032478581552 3.94983090544796e-13 NA NA NA hsa-miR-20a-5p RASGRF2 3.15577933619191 4.19753346442454e-25 -0.959101466033611 0.00295453490406439 MirTarget -0.384082682232264 2.28016569629488e-16 NA NA NA hsa-miR-20b-5p RASGRF2 2.07706563022469 1.10107236083433e-05 -0.959101466033611 0.00295453490406439 MirTarget -0.141765383171134 1.33829153900026e-05 NA NA NA hsa-miR-224-5p RASGRF2 2.94107125335675 5.72194099515157e-08 -0.959101466033611 0.00295453490406439 MirTarget -0.132472394468524 2.53083760354603e-06 NA NA NA hsa-miR-3065-5p RASGRF2 2.74629919868982 1.86846589298284e-08 -0.959101466033611 0.00295453490406439 mirMAP -0.207531450630493 5.32321107917532e-08 NA NA NA hsa-miR-30d-3p RASGRF2 0.977747550180601 4.3048212205381e-05 -0.959101466033611 0.00295453490406439 mirMAP -0.410211731840294 1.66853922844251e-10 NA NA NA hsa-miR-30e-3p RASGRF2 -0.215663037684509 0.235375122783546 -0.959101466033611 0.00295453490406439 mirMAP -0.245989417875303 0.00490846179850226 NA NA NA hsa-miR-320a RASGRF2 0.438165828017084 0.0390159073347133 -0.959101466033611 0.00295453490406439 miRNATAP -0.361437594493406 9.27311188942508e-07 NA NA NA hsa-miR-320b RASGRF2 1.55692969039548 1.41071034251915e-08 -0.959101466033611 0.00295453490406439 miRNATAP -0.383429578468431 2.99151617711296e-12 NA NA NA hsa-miR-324-5p RASGRF2 2.95683728155095 1.32960514360912e-20 -0.959101466033611 0.00295453490406439 miRNATAP -0.321261382335988 2.59014816441969e-12 NA NA NA hsa-miR-330-3p RASGRF2 0.876747334239085 0.00073709016089703 -0.959101466033611 0.00295453490406439 mirMAP -0.300392316226483 4.73745675980151e-07 NA NA NA hsa-miR-34a-3p RASGRF2 1.75590866103657 8.02801510630657e-09 -0.959101466033611 0.00295453490406439 mirMAP -0.243930495689873 1.30413895856795e-05 NA NA NA hsa-miR-421 RASGRF2 1.17791565395543 6.78526676976629e-06 -0.959101466033611 0.00295453490406439 miRanda;mirMAP -0.31493429928954 8.95779155643084e-08 NA NA NA hsa-miR-429 RASGRF2 4.48815175680773 2.44117492218206e-17 -0.959101466033611 0.00295453490406439 miRanda -0.200335097247864 3.96990043767509e-13 NA NA NA hsa-miR-491-5p RASGRF2 0.615770352820862 0.0418295628761654 -0.959101466033611 0.00295453490406439 miRanda -0.173260821253958 0.00181016260712164 NA NA NA hsa-miR-590-3p RASGRF2 2.59289455139753 1.03200520972022e-21 -0.959101466033611 0.00295453490406439 MirTarget;miRanda -0.342244796870533 7.80361504056741e-10 NA NA NA hsa-miR-590-5p RASGRF2 3.18300989862077 2.06813568597893e-26 -0.959101466033611 0.00295453490406439 miRanda -0.329198065863786 2.91399002348044e-11 NA NA NA hsa-miR-664a-3p RASGRF2 0.634721925861133 0.00520070178640421 -0.959101466033611 0.00295453490406439 mirMAP -0.246555400374732 0.000355617089927053 NA NA NA hsa-miR-93-5p RASGRF2 3.03961860136032 1.11672209617395e-24 -0.959101466033611 0.00295453490406439 MirTarget -0.403876760673153 4.83197709143151e-17 NA NA NA hsa-let-7a-5p RASGRP1 0.618599506841644 2.76973453058748e-05 0.191950588717897 0.655147955221155 MirTarget;TargetScan;miRNATAP -0.392494685914432 0.00597286583942776 NA NA NA hsa-let-7e-5p RASGRP1 0.860104282510173 6.04758298373779e-05 0.191950588717897 0.655147955221155 MirTarget;miRNATAP -0.583845569747264 8.68830027695287e-10 NA NA NA hsa-miR-30d-3p RASGRP1 0.977747550180601 4.3048212205381e-05 0.191950588717897 0.655147955221155 MirTarget -0.322587105988672 0.000191032301156401 NA NA NA hsa-miR-30e-3p RASGRP1 -0.215663037684509 0.235375122783546 0.191950588717897 0.655147955221155 MirTarget -0.302011426146603 0.00923112985675683 NA NA NA hsa-miR-320a RASGRP1 0.438165828017084 0.0390159073347133 0.191950588717897 0.655147955221155 miRanda -0.352883335036029 0.000331039020053233 NA NA NA hsa-miR-429 RASGRP1 4.48815175680773 2.44117492218206e-17 0.191950588717897 0.655147955221155 miRanda -0.156681950877704 2.73949847524052e-05 NA NA NA hsa-miR-582-5p RASGRP1 0.609226359812689 0.032988717891497 0.191950588717897 0.655147955221155 MirTarget -0.416220512178729 6.4599758610322e-09 NA NA NA hsa-miR-98-5p RASGRP1 1.11154309866014 1.24143909012085e-08 0.191950588717897 0.655147955221155 MirTarget -0.417025513810675 7.36774536256623e-05 NA NA NA hsa-miR-324-3p RASGRP2 2.08739139768981 3.11885987067952e-13 -3.16857887195918 2.09718322290424e-14 PITA -0.736048773206101 5.1111254858267e-29 NA NA NA hsa-miR-484 RASGRP2 1.81844463411787 1.82951571230938e-15 -3.16857887195918 2.09718322290424e-14 PITA -0.619332238576668 5.24531090786405e-13 NA NA NA hsa-miR-940 RASGRP2 3.21011374578759 2.7923171128495e-14 -3.16857887195918 2.09718322290424e-14 MirTarget;PITA;miRNATAP -0.521374023201122 1.22092840074636e-26 NA NA NA hsa-miR-324-3p RASGRP3 2.08739139768981 3.11885987067952e-13 -0.0443708040963782 0.850285116887387 MirTarget -0.168294979807098 1.11811257190529e-05 NA NA NA hsa-miR-28-5p RASGRP4 0.230152919654905 0.0742909586754846 -1.81932059503105 2.30066832429026e-06 miRanda -0.440690225574773 0.0034855563518016 NA NA NA hsa-miR-30b-3p RASGRP4 0.834142820354026 0.000972582820878813 -1.81932059503105 2.30066832429026e-06 MirTarget -0.65125310483836 1.05989377102438e-19 NA NA NA hsa-miR-34a-5p RASGRP4 1.9016323452565 1.43092834643601e-14 -1.81932059503105 2.30066832429026e-06 MirTarget -0.421860932834008 7.68217450355339e-09 NA NA NA hsa-miR-125b-5p RPS6KA1 -1.16462950151259 0.000288900271798384 1.34988540411024 1.15370611659724e-11 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.13692356644705 6.2422468067932e-06 NA NA NA hsa-miR-139-5p RPS6KA1 -1.52606598644743 1.20474151350665e-08 1.34988540411024 1.15370611659724e-11 miRanda -0.104159748301514 0.00411281450359946 NA NA NA hsa-let-7g-3p RPS6KA2 3.26398061402445 3.96263126107645e-25 -1.89918037721253 3.87074381310148e-13 MirTarget -0.246721753553459 3.41630640648566e-10 NA NA NA hsa-miR-1271-5p RPS6KA2 0.970418832993172 0.000609742584380688 -1.89918037721253 3.87074381310148e-13 mirMAP -0.20251993530887 9.27638787048565e-06 NA NA NA hsa-miR-130b-5p RPS6KA2 2.9963110846538 1.98883029416455e-18 -1.89918037721253 3.87074381310148e-13 mirMAP -0.235363829031829 1.54980286279085e-10 NA NA NA hsa-miR-17-5p RPS6KA2 3.2710598467455 9.93128340539455e-27 -1.89918037721253 3.87074381310148e-13 TargetScan -0.308938986160142 1.53086675306477e-15 NA NA NA hsa-miR-181a-2-3p RPS6KA2 2.19062681262366 3.81790102612782e-13 -1.89918037721253 3.87074381310148e-13 mirMAP -0.185814296672575 8.43603766197703e-06 NA NA NA hsa-miR-185-3p RPS6KA2 2.3922478518806 1.3373426768452e-14 -1.89918037721253 3.87074381310148e-13 MirTarget -0.23896304263491 2.26811072773796e-09 NA NA NA hsa-miR-193a-3p RPS6KA2 1.60460546928078 2.86169793322984e-07 -1.89918037721253 3.87074381310148e-13 mirMAP -0.182027317307988 8.38861562840483e-06 NA NA NA hsa-miR-193b-3p RPS6KA2 2.25711804611899 4.1940744806631e-14 -1.89918037721253 3.87074381310148e-13 mirMAP -0.311500359089077 3.53991075205589e-14 NA NA NA hsa-miR-19a-3p RPS6KA2 3.42309334186656 3.02671914353412e-28 -1.89918037721253 3.87074381310148e-13 MirTarget -0.274673751333933 6.75653405295878e-13 NA NA NA hsa-miR-19b-3p RPS6KA2 2.49529833021187 1.57028265846699e-23 -1.89918037721253 3.87074381310148e-13 MirTarget -0.319321802710713 4.74464788644084e-11 NA NA NA hsa-miR-200c-3p RPS6KA2 3.50132673580082 2.42716349086937e-15 -1.89918037721253 3.87074381310148e-13 miRNATAP -0.129334089352011 4.4517289901593e-06 NA NA NA hsa-miR-21-3p RPS6KA2 2.19296355304364 4.63665722759779e-15 -1.89918037721253 3.87074381310148e-13 MirTarget -0.272784541769791 7.52288789174635e-10 NA NA NA hsa-miR-26b-5p RPS6KA2 0.885393662798425 3.2116297961629e-06 -1.89918037721253 3.87074381310148e-13 miRNATAP -0.227177310507267 0.000899668091721707 NA NA NA hsa-miR-3065-5p RPS6KA2 2.74629919868982 1.86846589298284e-08 -1.89918037721253 3.87074381310148e-13 mirMAP -0.129392772331137 5.16506987695122e-05 NA NA NA hsa-miR-30e-5p RPS6KA2 1.23904909539663 1.35561917122157e-09 -1.89918037721253 3.87074381310148e-13 MirTarget -0.167397027801108 0.00795729353132801 NA NA NA hsa-miR-3127-5p RPS6KA2 1.51846438737133 3.59571251672767e-07 -1.89918037721253 3.87074381310148e-13 mirMAP -0.13587142025251 0.00161943122406181 NA NA NA hsa-miR-532-3p RPS6KA2 1.96631878320218 4.53421954361695e-13 -1.89918037721253 3.87074381310148e-13 MirTarget;mirMAP -0.217249391578203 2.76835498444362e-06 NA NA NA hsa-miR-589-5p RPS6KA2 1.71990116752371 8.310889042056e-14 -1.89918037721253 3.87074381310148e-13 mirMAP -0.333681503852927 7.42768576140755e-10 NA NA NA hsa-miR-93-3p RPS6KA2 2.85383869771942 5.64481766902125e-23 -1.89918037721253 3.87074381310148e-13 MirTarget -0.236183258286661 2.11710105875058e-08 NA NA NA hsa-let-7d-5p RPS6KA3 1.33236798905207 1.1741085658466e-13 -0.370806818018999 0.0220707753218686 miRNATAP -0.114489938702704 0.00756705340948625 NA NA NA hsa-miR-136-5p RPS6KA3 2.09637138292451 1.50140005592201e-10 -0.370806818018999 0.0220707753218686 mirMAP -0.117791568961288 3.67256904611671e-07 NA NA NA hsa-miR-181a-5p RPS6KA3 2.29556023480783 1.8138457900616e-21 -0.370806818018999 0.0220707753218686 MirTarget;mirMAP;miRNATAP -0.121039283729606 8.78983023529811e-05 NA NA NA hsa-miR-181c-5p RPS6KA3 1.58587920618301 1.57506918816933e-10 -0.370806818018999 0.0220707753218686 MirTarget;mirMAP;miRNATAP -0.137925322197845 7.60328156936309e-06 NA NA NA hsa-miR-186-5p RPS6KA3 1.47445398888668 3.0781726595413e-15 -0.370806818018999 0.0220707753218686 MirTarget;mirMAP;miRNATAP -0.111734638474146 0.00635139835787659 NA NA NA hsa-miR-21-5p RPS6KA3 2.73773305747971 1.38864982139576e-43 -0.370806818018999 0.0220707753218686 miRNAWalker2_validate;mirMAP;miRNATAP -0.115651579127679 0.00124546897217506 NA NA NA hsa-miR-320a RPS6KA3 0.438165828017084 0.0390159073347133 -0.370806818018999 0.0220707753218686 miRNAWalker2_validate;miRanda -0.105734074591902 0.00443346974555563 NA NA NA hsa-miR-25-3p RPS6KA4 1.36472605225697 4.83790725935681e-11 0.691826748311756 7.91091742889804e-05 MirTarget -0.145771432406332 0.000304038062710177 NA NA NA hsa-miR-363-3p RPS6KA4 1.50575300026701 0.00020976164678918 0.691826748311756 7.91091742889804e-05 MirTarget -0.119696919430121 5.65615975795963e-09 NA NA NA hsa-miR-423-5p RPS6KA4 0.963563145758616 9.86109015204915e-07 0.691826748311756 7.91091742889804e-05 MirTarget -0.122065107603161 0.00474772215273447 NA NA NA hsa-miR-106b-5p RPS6KA5 2.46782146831112 1.36171495805632e-23 -1.70962855889487 4.52042697209154e-09 MirTarget -0.164628915684484 0.00292025561584619 NA NA NA hsa-miR-10b-3p RPS6KA5 0.77597971642517 0.00264877454133753 -1.70962855889487 4.52042697209154e-09 MirTarget -0.183937322489807 0.000935254548911832 NA NA NA hsa-miR-128-3p RPS6KA5 1.63756041666078 6.79626586407187e-14 -1.70962855889487 4.52042697209154e-09 miRNAWalker2_validate;MirTarget -0.196429963930607 0.00219250450812251 NA NA NA hsa-miR-130a-3p RPS6KA5 2.02021855058359 1.26427102520415e-11 -1.70962855889487 4.52042697209154e-09 MirTarget -0.2394477302706 2.68600380502292e-07 NA NA NA hsa-miR-130b-3p RPS6KA5 3.5350292994509 1.73934183852569e-27 -1.70962855889487 4.52042697209154e-09 MirTarget -0.16085369813362 9.3524660055839e-05 NA NA NA hsa-miR-142-5p RPS6KA5 1.17581605694506 0.0018174701991234 -1.70962855889487 4.52042697209154e-09 MirTarget;PITA;mirMAP;miRNATAP -0.10937951853429 0.00392133535700338 NA NA NA hsa-miR-148a-3p RPS6KA5 1.26728238710376 2.52325607402829e-06 -1.70962855889487 4.52042697209154e-09 miRNAWalker2_validate;miRTarBase;MirTarget -0.140257061314002 0.00809054476069603 20406806 MiR 148a attenuates paclitaxel resistance of hormone refractory drug resistant prostate cancer PC3 cells by regulating MSK1 expression; Computer-aided algorithms predicted mitogen- and stress-activated protein kinase MSK1 as a potential target of miR-148a; Indeed miR-148a overexpression decreased expression of MSK1; Using luciferase reporter assays we identified MSK1 as a direct target of miR-148a; MiR-148a reduced MSK1 expression by directly targeting its 3'-UTR in PC3PR cells; Furthermore MSK1 knockdown reduced paclitaxel-resistance of PC3PR cells indicating that miR-148a attenuates paclitaxel-resistance of hormone-refractory drug-resistant PC3PR cells in part by regulating MSK1 expression drug resistance prostate cancer hsa-miR-148b-3p RPS6KA5 1.97815018171325 6.07715327281595e-26 -1.70962855889487 4.52042697209154e-09 MirTarget -0.270725249004095 0.000184908570985868 NA NA NA hsa-miR-17-5p RPS6KA5 3.2710598467455 9.93128340539455e-27 -1.70962855889487 4.52042697209154e-09 MirTarget;TargetScan -0.173158104675667 8.14165092616476e-05 NA NA NA hsa-miR-18a-5p RPS6KA5 3.78535678765353 3.72446596213886e-26 -1.70962855889487 4.52042697209154e-09 MirTarget -0.156521279378493 8.025505543386e-05 NA NA NA hsa-miR-199a-5p RPS6KA5 0.592984035153911 0.0674836634175293 -1.70962855889487 4.52042697209154e-09 miRanda -0.235108660725906 7.88901578000281e-08 NA NA NA hsa-miR-199b-5p RPS6KA5 0.218704279044827 0.519493319158441 -1.70962855889487 4.52042697209154e-09 miRanda -0.221459920945231 1.24945283500248e-07 NA NA NA hsa-miR-19a-3p RPS6KA5 3.42309334186656 3.02671914353412e-28 -1.70962855889487 4.52042697209154e-09 miRNAWalker2_validate;MirTarget -0.20300260101966 2.21807853590169e-06 NA NA NA hsa-miR-19b-3p RPS6KA5 2.49529833021187 1.57028265846699e-23 -1.70962855889487 4.52042697209154e-09 MirTarget -0.24092736920896 9.05787955794495e-06 NA NA NA hsa-miR-20a-3p RPS6KA5 2.92621109947706 2.49504904635375e-17 -1.70962855889487 4.52042697209154e-09 miRNATAP -0.117628717271585 0.00416390296700751 NA NA NA hsa-miR-20a-5p RPS6KA5 3.15577933619191 4.19753346442454e-25 -1.70962855889487 4.52042697209154e-09 MirTarget -0.186783012178187 2.35642199090142e-05 NA NA NA hsa-miR-23a-3p RPS6KA5 1.00493340843378 2.55313889288924e-08 -1.70962855889487 4.52042697209154e-09 mirMAP -0.331361890973973 2.68353866335746e-05 NA NA NA hsa-miR-27a-3p RPS6KA5 1.66542180327138 4.93775737894805e-13 -1.70962855889487 4.52042697209154e-09 miRNAWalker2_validate;MirTarget;miRNATAP -0.336072714288731 2.26919901812192e-08 NA NA NA hsa-miR-28-5p RPS6KA5 0.230152919654905 0.0742909586754846 -1.70962855889487 4.52042697209154e-09 miRanda -0.315380639309258 0.00612212557450078 NA NA NA hsa-miR-301a-3p RPS6KA5 2.81024345929638 2.29784847962242e-17 -1.70962855889487 4.52042697209154e-09 MirTarget -0.135405462031699 0.00210009061693288 NA NA NA hsa-miR-335-3p RPS6KA5 3.08791651139852 5.31309869723517e-12 -1.70962855889487 4.52042697209154e-09 mirMAP -0.110704455210691 0.000375162763804628 NA NA NA hsa-miR-342-3p RPS6KA5 1.49115144672245 1.43879249744621e-07 -1.70962855889487 4.52042697209154e-09 PITA;miRanda;miRNATAP -0.184364781261536 0.000220853821053261 NA NA NA hsa-miR-454-3p RPS6KA5 2.47234127820054 1.12878018736016e-21 -1.70962855889487 4.52042697209154e-09 MirTarget -0.209228333353288 0.000114927249403912 NA NA NA hsa-miR-493-5p RPS6KA5 0.847772103665986 0.00528678068747754 -1.70962855889487 4.52042697209154e-09 MirTarget -0.217680162131994 3.6405359626477e-06 NA NA NA hsa-miR-590-3p RPS6KA5 2.59289455139753 1.03200520972022e-21 -1.70962855889487 4.52042697209154e-09 miRanda -0.180375618305625 0.00049963455228842 NA NA NA hsa-miR-664a-3p RPS6KA5 0.634721925861133 0.00520070178640421 -1.70962855889487 4.52042697209154e-09 MirTarget;mirMAP -0.242094424839758 0.000129230079593435 NA NA NA hsa-miR-93-5p RPS6KA5 3.03961860136032 1.11672209617395e-24 -1.70962855889487 4.52042697209154e-09 miRNAWalker2_validate;MirTarget -0.168904593981227 0.00021386518322506 NA NA NA hsa-miR-942-5p RPS6KA5 2.35195531153712 5.45059325728841e-16 -1.70962855889487 4.52042697209154e-09 MirTarget -0.139362741646398 0.00355057544255994 NA NA NA hsa-miR-1271-5p RPS6KA6 0.970418832993172 0.000609742584380688 -0.643070571271251 0.264542356112038 MirTarget -0.28783551839478 0.00344430588607334 NA NA NA hsa-miR-199a-3p RPS6KA6 0.640600337515787 0.0380326905134914 -0.643070571271251 0.264542356112038 MirTarget -0.494218120175028 2.93790214049553e-08 NA NA NA hsa-miR-199b-3p RPS6KA6 0.643923492750702 0.0371742251925406 -0.643070571271251 0.264542356112038 MirTarget -0.493553319945077 2.99976098785352e-08 NA NA NA hsa-miR-217 RPS6KA6 0.608024397387488 0.199352491710517 -0.643070571271251 0.264542356112038 miRanda -0.218929391103907 0.000280286435780485 NA NA NA hsa-miR-655-3p RPS6KA6 0.485339318272148 0.137014658258732 -0.643070571271251 0.264542356112038 MirTarget -0.294210829929277 0.000704709579255314 NA NA NA hsa-miR-1306-3p RRAS 1.7835592527682 5.37873730566685e-08 -1.13229828735822 2.92783846173343e-05 MirTarget -0.342468358104518 1.07516903906357e-16 NA NA NA hsa-miR-34a-5p RRAS 1.9016323452565 1.43092834643601e-14 -1.13229828735822 2.92783846173343e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.265547196825665 2.42146653994062e-07 NA NA NA hsa-miR-491-5p RRAS 0.615770352820862 0.0418295628761654 -1.13229828735822 2.92783846173343e-05 miRanda;miRNATAP -0.168893307778227 0.000304382875911956 NA NA NA hsa-miR-106b-5p RRAS2 2.46782146831112 1.36171495805632e-23 -0.336573394273787 0.157806837161319 miRNATAP -0.123529820016572 0.00536363783110175 NA NA NA hsa-miR-23b-3p RRAS2 -0.251132426825047 0.150200321210792 -0.336573394273787 0.157806837161319 MirTarget -0.251243741073941 0.000167519448808664 NA NA NA hsa-miR-29c-3p RRAS2 -0.00968972577705429 0.97099586346872 -0.336573394273787 0.157806837161319 miRNATAP -0.246106967000447 8.92437448436791e-09 NA NA NA hsa-miR-30c-5p RRAS2 0.778774633108 0.000285599212429136 -0.336573394273787 0.157806837161319 miRNATAP -0.224804628188931 2.59774897524192e-05 NA NA NA hsa-miR-30d-5p RRAS2 0.675423997639582 0.00270618816039773 -0.336573394273787 0.157806837161319 miRNATAP -0.270482191429642 9.49506233839001e-08 NA NA NA hsa-miR-320a RRAS2 0.438165828017084 0.0390159073347133 -0.336573394273787 0.157806837161319 miRanda -0.189633132897342 0.000505503813738761 NA NA NA hsa-miR-33a-3p RRAS2 1.72765312072219 1.51784443453521e-07 -0.336573394273787 0.157806837161319 MirTarget -0.122485392721008 0.00123341311117024 NA NA NA hsa-miR-429 RRAS2 4.48815175680773 2.44117492218206e-17 -0.336573394273787 0.157806837161319 PITA;miRanda -0.131885659535421 1.05798206265027e-10 NA NA NA hsa-miR-93-5p RRAS2 3.03961860136032 1.11672209617395e-24 -0.336573394273787 0.157806837161319 miRNAWalker2_validate -0.112014989761344 0.00224791308670307 NA NA NA hsa-miR-132-3p SOS1 0.156276992635384 0.408190812100704 -0.16498215834071 0.203173827793335 miRNATAP -0.124479028859718 0.000189720665201441 NA NA NA hsa-miR-140-3p SOS1 0.0608890720479334 0.727716871248724 -0.16498215834071 0.203173827793335 miRNATAP -0.101782613385997 0.00502361468434803 NA NA NA hsa-miR-23a-3p SOS1 1.00493340843378 2.55313889288924e-08 -0.16498215834071 0.203173827793335 mirMAP -0.129314634656678 0.000166578408604821 NA NA NA hsa-miR-26a-2-3p SOS1 0.823520019989974 0.00017092160823769 -0.16498215834071 0.203173827793335 mirMAP -0.118538447529583 3.24943288286622e-05 NA NA NA hsa-miR-27a-3p SOS1 1.66542180327138 4.93775737894805e-13 -0.16498215834071 0.203173827793335 MirTarget;miRNATAP -0.122545061941616 3.0550593865242e-06 NA NA NA hsa-miR-30a-5p SOS1 -0.878357906436456 0.000509952992366057 -0.16498215834071 0.203173827793335 mirMAP;miRNATAP -0.11057365509939 6.32062418728583e-06 NA NA NA hsa-miR-140-5p SOS2 0.844753502512594 3.73722278438606e-05 -0.541773165962052 3.38343002773895e-05 miRanda -0.175305178985449 9.75022022997209e-09 NA NA NA hsa-miR-146b-5p SOS2 1.75587235896724 1.15724631266659e-07 -0.541773165962052 3.38343002773895e-05 miRanda -0.115152479666608 5.46824888444679e-10 NA NA NA hsa-miR-15a-5p SOS2 2.34669284378787 1.69544424500258e-23 -0.541773165962052 3.38343002773895e-05 miRNATAP -0.100823047270651 8.09178891804544e-05 NA NA NA hsa-miR-193a-3p SOS2 1.60460546928078 2.86169793322984e-07 -0.541773165962052 3.38343002773895e-05 PITA;miRanda;miRNATAP -0.115828791088816 4.45409413355469e-09 NA NA NA hsa-miR-199a-5p SOS2 0.592984035153911 0.0674836634175293 -0.541773165962052 3.38343002773895e-05 PITA;miRanda;miRNATAP -0.106315824647688 3.80818848808324e-08 NA NA NA hsa-miR-199b-5p SOS2 0.218704279044827 0.519493319158441 -0.541773165962052 3.38343002773895e-05 PITA;miRanda;miRNATAP -0.110351567625311 2.11664365720639e-09 NA NA NA hsa-miR-21-5p SOS2 2.73773305747971 1.38864982139576e-43 -0.541773165962052 3.38343002773895e-05 miRNATAP -0.17866087041205 3.99766997060001e-10 NA NA NA hsa-miR-424-5p SOS2 1.61930224569578 1.89642549274994e-10 -0.541773165962052 3.38343002773895e-05 miRNATAP -0.10457735471019 1.79360950512032e-05 NA NA NA hsa-miR-454-3p SOS2 2.47234127820054 1.12878018736016e-21 -0.541773165962052 3.38343002773895e-05 miRNATAP -0.106988836200975 7.58489665683655e-06 NA NA NA hsa-miR-493-5p SOS2 0.847772103665986 0.00528678068747754 -0.541773165962052 3.38343002773895e-05 miRNATAP -0.107549440318842 2.05055453955094e-07 NA NA NA hsa-miR-590-3p SOS2 2.59289455139753 1.03200520972022e-21 -0.541773165962052 3.38343002773895e-05 miRanda;mirMAP -0.115775809148697 3.43791025032322e-07 NA NA NA hsa-miR-590-5p SOS2 3.18300989862077 2.06813568597893e-26 -0.541773165962052 3.38343002773895e-05 PITA;miRanda;miRNATAP -0.105807242898967 1.7586879655633e-07 NA NA NA hsa-miR-101-3p SRF 0.522819989585461 0.00375627731618038 -1.54762802860391 1.84904741152095e-30 miRNATAP -0.201059518932614 2.19574274282453e-07 NA NA NA hsa-miR-10a-5p SRF 1.15016989191194 0.00372037233992369 -1.54762802860391 1.84904741152095e-30 mirMAP -0.1020805104791 3.76329675676264e-09 NA NA NA hsa-miR-125a-5p SRF 0.599529391575274 0.0102300147180307 -1.54762802860391 1.84904741152095e-30 mirMAP -0.13579699660111 5.58208979872605e-06 NA NA NA hsa-miR-130b-3p SRF 3.5350292994509 1.73934183852569e-27 -1.54762802860391 1.84904741152095e-30 mirMAP -0.175779554785613 8.42992584119779e-20 NA NA NA hsa-miR-130b-5p SRF 2.9963110846538 1.98883029416455e-18 -1.54762802860391 1.84904741152095e-30 mirMAP -0.168099001011298 4.32006326144185e-18 NA NA NA hsa-miR-148a-3p SRF 1.26728238710376 2.52325607402829e-06 -1.54762802860391 1.84904741152095e-30 mirMAP -0.109513629301619 1.96401417529461e-05 NA NA NA hsa-miR-148b-3p SRF 1.97815018171325 6.07715327281595e-26 -1.54762802860391 1.84904741152095e-30 mirMAP -0.364963492212976 4.02917858746474e-28 NA NA NA hsa-miR-148b-5p SRF 2.18024067300781 2.84770452413262e-14 -1.54762802860391 1.84904741152095e-30 mirMAP -0.180028933328062 1.68065148623513e-13 NA NA NA hsa-miR-185-3p SRF 2.3922478518806 1.3373426768452e-14 -1.54762802860391 1.84904741152095e-30 MirTarget;miRNATAP -0.178300843535103 2.49598110041878e-17 NA NA NA hsa-miR-1976 SRF 2.06550563678192 7.81396978619772e-18 -1.54762802860391 1.84904741152095e-30 mirMAP -0.219668134615276 6.93580819992573e-16 NA NA NA hsa-miR-200a-3p SRF 4.59434485520731 6.38952518573476e-18 -1.54762802860391 1.84904741152095e-30 miRTarBase -0.146541248340303 4.81881096872603e-37 NA NA NA hsa-miR-200b-3p SRF 3.78235093249346 3.18343003239465e-14 -1.54762802860391 1.84904741152095e-30 TargetScan -0.158205333233583 4.7777810324846e-37 NA NA NA hsa-miR-200c-3p SRF 3.50132673580082 2.42716349086937e-15 -1.54762802860391 1.84904741152095e-30 miRNATAP -0.164183916101306 6.86000844726545e-31 NA NA NA hsa-miR-26b-5p SRF 0.885393662798425 3.2116297961629e-06 -1.54762802860391 1.84904741152095e-30 miRNAWalker2_validate -0.18662598239394 3.10308190445638e-07 NA NA NA hsa-miR-30b-3p SRF 0.834142820354026 0.000972582820878813 -1.54762802860391 1.84904741152095e-30 MirTarget -0.132078375080874 1.68733914987766e-06 NA NA NA hsa-miR-320a SRF 0.438165828017084 0.0390159073347133 -1.54762802860391 1.84904741152095e-30 miRNAWalker2_validate;miRanda -0.137568838125847 3.18388785666443e-05 NA NA NA hsa-miR-320b SRF 1.55692969039548 1.41071034251915e-08 -1.54762802860391 1.84904741152095e-30 miRanda -0.17540876488179 8.71314542975458e-13 NA NA NA hsa-miR-324-3p SRF 2.08739139768981 3.11885987067952e-13 -1.54762802860391 1.84904741152095e-30 miRNAWalker2_validate -0.192906721001229 4.3507802906846e-17 NA NA NA hsa-miR-324-5p SRF 2.95683728155095 1.32960514360912e-20 -1.54762802860391 1.84904741152095e-30 MirTarget;PITA;miRanda;miRNATAP -0.172000617644768 2.01943812306396e-17 NA NA NA hsa-miR-331-3p SRF 2.28379581858927 1.99663919173155e-18 -1.54762802860391 1.84904741152095e-30 miRNAWalker2_validate;mirMAP;miRNATAP -0.202691252728234 4.78395539286845e-16 NA NA NA hsa-miR-423-5p SRF 0.963563145758616 9.86109015204915e-07 -1.54762802860391 1.84904741152095e-30 miRNATAP -0.278169091472521 5.45144815280581e-16 NA NA NA hsa-miR-429 SRF 4.48815175680773 2.44117492218206e-17 -1.54762802860391 1.84904741152095e-30 PITA;miRanda;miRNATAP -0.150830858998984 5.26635334187113e-39 NA NA NA hsa-miR-454-3p SRF 2.47234127820054 1.12878018736016e-21 -1.54762802860391 1.84904741152095e-30 mirMAP -0.220010843114143 7.33924660960164e-18 NA NA NA hsa-miR-484 SRF 1.81844463411787 1.82951571230938e-15 -1.54762802860391 1.84904741152095e-30 miRNAWalker2_validate -0.245504194874069 1.03435721154639e-17 NA NA NA hsa-miR-532-3p SRF 1.96631878320218 4.53421954361695e-13 -1.54762802860391 1.84904741152095e-30 MirTarget;miRNATAP -0.199673415072917 1.9228831047526e-16 NA NA NA hsa-miR-590-3p SRF 2.59289455139753 1.03200520972022e-21 -1.54762802860391 1.84904741152095e-30 miRanda -0.191385822753815 6.5328494244198e-15 NA NA NA hsa-miR-92a-3p SRF 2.06460102658973 1.44784291084757e-19 -1.54762802860391 1.84904741152095e-30 miRNAWalker2_validate -0.228562429194699 1.20668279234375e-15 NA NA NA hsa-miR-125a-5p STK3 0.599529391575274 0.0102300147180307 0.157754074583901 0.310254102765732 miRanda -0.13587832062123 2.21374644392661e-05 NA NA NA hsa-miR-28-3p STK3 -0.411384408160536 0.0101470262574251 0.157754074583901 0.310254102765732 MirTarget;PITA -0.155202128918813 0.00109276407887798 NA NA NA hsa-miR-29b-2-5p STK3 0.910668640983475 0.00666655585493488 0.157754074583901 0.310254102765732 MirTarget -0.195013061955265 6.37818523255653e-20 NA NA NA hsa-miR-582-5p STK3 0.609226359812689 0.032988717891497 0.157754074583901 0.310254102765732 MirTarget -0.134638518110038 2.17281536954597e-07 NA NA NA hsa-let-7d-5p TAOK1 1.33236798905207 1.1741085658466e-13 -0.507192494879209 0.107943198436468 miRNATAP -0.268769303342535 0.00127270675849272 NA NA NA hsa-miR-130a-3p TAOK1 2.02021855058359 1.26427102520415e-11 -0.507192494879209 0.107943198436468 mirMAP -0.174008102400034 0.000483911614507779 NA NA NA hsa-miR-139-5p TAOK1 -1.52606598644743 1.20474151350665e-08 -0.507192494879209 0.107943198436468 PITA;miRanda;mirMAP;miRNATAP -0.178085679546931 0.0015133320873855 NA NA NA hsa-miR-140-3p TAOK1 0.0608890720479334 0.727716871248724 -0.507192494879209 0.107943198436468 mirMAP -0.328695856391433 0.000201418941905065 NA NA NA hsa-miR-140-5p TAOK1 0.844753502512594 3.73722278438606e-05 -0.507192494879209 0.107943198436468 miRanda -0.245159751415159 0.000990905014973656 NA NA NA hsa-miR-15a-5p TAOK1 2.34669284378787 1.69544424500258e-23 -0.507192494879209 0.107943198436468 MirTarget -0.283422483112676 3.74881842413832e-06 NA NA NA hsa-miR-17-5p TAOK1 3.2710598467455 9.93128340539455e-27 -0.507192494879209 0.107943198436468 TargetScan;miRNATAP -0.153986701331569 0.00100478800185784 NA NA NA hsa-miR-181a-5p TAOK1 2.29556023480783 1.8138457900616e-21 -0.507192494879209 0.107943198436468 mirMAP;miRNATAP -0.32357322539166 5.89553930466738e-08 NA NA NA hsa-miR-181b-5p TAOK1 2.49307679431293 3.92829250217627e-20 -0.507192494879209 0.107943198436468 mirMAP;miRNATAP -0.193834694377948 0.00030409894344575 NA NA NA hsa-miR-181c-5p TAOK1 1.58587920618301 1.57506918816933e-10 -0.507192494879209 0.107943198436468 mirMAP;miRNATAP -0.256947082139066 1.9325403921677e-05 NA NA NA hsa-miR-186-5p TAOK1 1.47445398888668 3.0781726595413e-15 -0.507192494879209 0.107943198436468 mirMAP -0.248171986148354 0.00185095707924979 NA NA NA hsa-miR-199a-5p TAOK1 0.592984035153911 0.0674836634175293 -0.507192494879209 0.107943198436468 MirTarget;miRanda;miRNATAP -0.213966507779866 4.67632147069258e-06 NA NA NA hsa-miR-199b-5p TAOK1 0.218704279044827 0.519493319158441 -0.507192494879209 0.107943198436468 MirTarget;miRanda;miRNATAP -0.225696331499143 4.09973029589153e-07 NA NA NA hsa-miR-19a-3p TAOK1 3.42309334186656 3.02671914353412e-28 -0.507192494879209 0.107943198436468 MirTarget;miRNATAP -0.208140676895728 5.03591851056606e-06 NA NA NA hsa-miR-19b-3p TAOK1 2.49529833021187 1.57028265846699e-23 -0.507192494879209 0.107943198436468 MirTarget;miRNATAP -0.255135857897608 9.68330716809757e-06 NA NA NA hsa-miR-20a-5p TAOK1 3.15577933619191 4.19753346442454e-25 -0.507192494879209 0.107943198436468 miRNATAP -0.20601065675461 1.11587712838998e-05 NA NA NA hsa-miR-217 TAOK1 0.608024397387488 0.199352491710517 -0.507192494879209 0.107943198436468 miRanda -0.107510864569322 0.00114020603561642 NA NA NA hsa-miR-26a-2-3p TAOK1 0.823520019989974 0.00017092160823769 -0.507192494879209 0.107943198436468 mirMAP -0.319771361358014 4.36466340722033e-06 NA NA NA hsa-miR-26b-5p TAOK1 0.885393662798425 3.2116297961629e-06 -0.507192494879209 0.107943198436468 mirMAP;miRNATAP -0.276323484601423 0.000564077625941661 NA NA NA hsa-miR-29a-5p TAOK1 1.46749674755271 3.34605004270294e-07 -0.507192494879209 0.107943198436468 mirMAP -0.272437906668054 7.22995437358246e-07 NA NA NA hsa-miR-29b-2-5p TAOK1 0.910668640983475 0.00666655585493488 -0.507192494879209 0.107943198436468 MirTarget -0.167290604997312 0.000219965970350209 NA NA NA hsa-miR-30a-5p TAOK1 -0.878357906436456 0.000509952992366057 -0.507192494879209 0.107943198436468 MirTarget;miRNATAP -0.254950527143589 2.1306055229929e-05 NA NA NA hsa-miR-30b-5p TAOK1 0.800822374912712 0.000133601914525413 -0.507192494879209 0.107943198436468 miRNAWalker2_validate;MirTarget -0.202902966718696 0.00540808967730264 NA NA NA hsa-miR-30c-5p TAOK1 0.778774633108 0.000285599212429136 -0.507192494879209 0.107943198436468 MirTarget;miRNATAP -0.393088767180948 2.22809077065898e-08 NA NA NA hsa-miR-30e-5p TAOK1 1.23904909539663 1.35561917122157e-09 -0.507192494879209 0.107943198436468 MirTarget -0.243805508627126 0.000945197060910665 NA NA NA hsa-miR-320a TAOK1 0.438165828017084 0.0390159073347133 -0.507192494879209 0.107943198436468 mirMAP;miRNATAP -0.22065124484923 0.00230394910529653 NA NA NA hsa-miR-342-3p TAOK1 1.49115144672245 1.43879249744621e-07 -0.507192494879209 0.107943198436468 miRanda -0.271530957663835 2.46477363406945e-07 NA NA NA hsa-miR-362-3p TAOK1 2.0756816987665 3.89026064579331e-12 -0.507192494879209 0.107943198436468 miRanda -0.153719425349972 0.00280954899444899 NA NA NA hsa-miR-374a-3p TAOK1 0.533309330504947 0.00192918429705142 -0.507192494879209 0.107943198436468 mirMAP -0.236717981342401 0.00840654744679859 NA NA NA hsa-miR-454-3p TAOK1 2.47234127820054 1.12878018736016e-21 -0.507192494879209 0.107943198436468 mirMAP -0.251322285945211 1.23299644926126e-05 NA NA NA hsa-miR-455-5p TAOK1 2.2582442061694 1.43472128037398e-13 -0.507192494879209 0.107943198436468 MirTarget;miRNATAP -0.136413731983923 0.00496485341026221 NA NA NA hsa-miR-497-5p TAOK1 0.0257087130056286 0.918145413833358 -0.507192494879209 0.107943198436468 MirTarget -0.161862674692382 0.00843097118854252 NA NA NA hsa-miR-576-5p TAOK1 2.20467023993664 3.4053475193793e-19 -0.507192494879209 0.107943198436468 mirMAP -0.242923287014187 4.12227228632544e-05 NA NA NA hsa-miR-582-5p TAOK1 0.609226359812689 0.032988717891497 -0.507192494879209 0.107943198436468 MirTarget;miRNATAP -0.138058184976218 0.00992058604615985 NA NA NA hsa-miR-655-3p TAOK1 0.485339318272148 0.137014658258732 -0.507192494879209 0.107943198436468 MirTarget -0.12406124804622 0.00927053934297078 NA NA NA hsa-miR-664a-3p TAOK1 0.634721925861133 0.00520070178640421 -0.507192494879209 0.107943198436468 mirMAP -0.303339964618602 5.88424174960209e-06 NA NA NA hsa-miR-93-5p TAOK1 3.03961860136032 1.11672209617395e-24 -0.507192494879209 0.107943198436468 miRNATAP -0.164637947672854 0.00069289382730846 NA NA NA hsa-miR-106b-5p TAOK3 2.46782146831112 1.36171495805632e-23 -0.262240708594527 0.078726261746428 MirTarget -0.108006722301559 9.09540773541038e-05 NA NA NA hsa-miR-17-5p TAOK3 3.2710598467455 9.93128340539455e-27 -0.262240708594527 0.078726261746428 MirTarget;TargetScan -0.111252240376683 3.660685745056e-07 NA NA NA hsa-miR-19b-1-5p TAOK3 2.57951428759379 4.31576118703427e-20 -0.262240708594527 0.078726261746428 MirTarget -0.112005327153532 7.37331295319271e-06 NA NA NA hsa-miR-20a-5p TAOK3 3.15577933619191 4.19753346442454e-25 -0.262240708594527 0.078726261746428 MirTarget -0.118724882960096 6.58184108462706e-08 NA NA NA hsa-miR-93-5p TAOK3 3.03961860136032 1.11672209617395e-24 -0.262240708594527 0.078726261746428 MirTarget -0.125241236169725 3.0915765193195e-08 NA NA NA hsa-miR-744-5p TGFB1 1.48254348878737 3.23019501613577e-09 -0.000200257511168367 0.999409206375481 miRNAWalker2_validate;miRNATAP -0.229419410482444 6.9384219754003e-06 NA NA NA hsa-miR-107 TGFB2 1.30977326593435 1.30372468603965e-11 -1.19931727990522 0.00330886829654418 miRanda -0.51939474457829 1.98547903259176e-07 NA NA NA hsa-miR-126-5p TGFB2 0.895338176458417 2.33372756450713e-05 -1.19931727990522 0.00330886829654418 mirMAP -0.25743093726133 0.00599073764101041 NA NA NA hsa-miR-130b-3p TGFB2 3.5350292994509 1.73934183852569e-27 -1.19931727990522 0.00330886829654418 MirTarget;miRNATAP -0.344962470893237 7.65363506175553e-10 NA NA NA hsa-miR-141-3p TGFB2 5.02396127982626 2.19224509139725e-24 -1.19931727990522 0.00330886829654418 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.360699351018386 8.70106540908034e-24 NA NA NA hsa-miR-148a-3p TGFB2 1.26728238710376 2.52325607402829e-06 -1.19931727990522 0.00330886829654418 MirTarget;miRNATAP -0.286009485859132 8.40361643900754e-05 NA NA NA hsa-miR-148b-3p TGFB2 1.97815018171325 6.07715327281595e-26 -1.19931727990522 0.00330886829654418 MirTarget -0.76533615341931 3.3613707731401e-15 NA NA NA hsa-miR-149-5p TGFB2 2.94200492826326 4.93436498919036e-14 -1.19931727990522 0.00330886829654418 MirTarget;miRNATAP -0.268302009449797 3.19540597089803e-08 NA NA NA hsa-miR-186-5p TGFB2 1.47445398888668 3.0781726595413e-15 -1.19931727990522 0.00330886829654418 mirMAP -0.621355169758057 1.07645506474653e-09 NA NA NA hsa-miR-200a-3p TGFB2 4.59434485520731 6.38952518573476e-18 -1.19931727990522 0.00330886829654418 MirTarget;miRNATAP -0.349625252947739 2.44117272738656e-25 25813153 Tumor suppressive microRNA 200a inhibits renal cell carcinoma development by directly targeting TGFB2; By performing quantitative real-time PCR ELISA and luciferase reporter assays transforming growth factor beta2 TGFB2 was validated as a direct target gene of miR-200a; Moreover siRNA-mediated knockdown of TGFB2 partially phenocopied the effect of miR-200a overexpression; These results suggest that miR-200a suppresses RCC development via directly targeting TGFB2 indicating that miR-200a may present a novel target for diagnostic and therapeutic strategies in RCC kidney renal cell cancer hsa-miR-203a-3p TGFB2 3.12352008343999 9.49391438647189e-07 -1.19931727990522 0.00330886829654418 MirTarget -0.137892151335788 5.76268091391752e-06 NA NA NA hsa-miR-29b-3p TGFB2 1.65828197923813 1.02676780888141e-09 -1.19931727990522 0.00330886829654418 miRTarBase;MirTarget;miRNATAP -0.231729413265765 0.0012231669483933 NA NA NA hsa-miR-29c-3p TGFB2 -0.00968972577705429 0.97099586346872 -1.19931727990522 0.00330886829654418 MirTarget;miRNATAP -0.531424404132598 2.96641887384219e-13 NA NA NA hsa-miR-301a-3p TGFB2 2.81024345929638 2.29784847962242e-17 -1.19931727990522 0.00330886829654418 MirTarget;miRNATAP -0.322704555190408 7.77034372961379e-08 NA NA NA hsa-miR-32-3p TGFB2 2.02436999565685 5.94091197945307e-09 -1.19931727990522 0.00330886829654418 mirMAP -0.27315114570865 1.69846948907938e-05 NA NA NA hsa-miR-320a TGFB2 0.438165828017084 0.0390159073347133 -1.19931727990522 0.00330886829654418 miRanda -0.39585907442477 2.33018021074793e-05 NA NA NA hsa-miR-320b TGFB2 1.55692969039548 1.41071034251915e-08 -1.19931727990522 0.00330886829654418 miRanda -0.298228917269413 2.53643349382992e-05 NA NA NA hsa-miR-324-5p TGFB2 2.95683728155095 1.32960514360912e-20 -1.19931727990522 0.00330886829654418 miRanda -0.302705023736643 2.71602770897574e-07 NA NA NA hsa-miR-330-3p TGFB2 0.876747334239085 0.00073709016089703 -1.19931727990522 0.00330886829654418 miRNATAP -0.457254743325048 1.06037579343258e-09 NA NA NA hsa-miR-330-5p TGFB2 1.15100069700871 4.85551805046014e-07 -1.19931727990522 0.00330886829654418 miRanda -0.360450971736555 2.54978879561545e-05 NA NA NA hsa-miR-331-5p TGFB2 2.17414714166315 1.54547681391888e-18 -1.19931727990522 0.00330886829654418 miRNATAP -0.239937976385475 0.00244538329219784 NA NA NA hsa-miR-335-3p TGFB2 3.08791651139852 5.31309869723517e-12 -1.19931727990522 0.00330886829654418 mirMAP -0.22185528629857 1.89547879442152e-07 NA NA NA hsa-miR-335-5p TGFB2 1.77247705492746 2.22457658872091e-06 -1.19931727990522 0.00330886829654418 miRNAWalker2_validate -0.252111592909568 1.14412319370904e-06 NA NA NA hsa-miR-33a-3p TGFB2 1.72765312072219 1.51784443453521e-07 -1.19931727990522 0.00330886829654418 MirTarget;mirMAP -0.371056624502634 8.36332661191753e-09 NA NA NA hsa-miR-361-5p TGFB2 0.971859117235239 5.30236555707088e-09 -1.19931727990522 0.00330886829654418 miRNATAP -0.810004741713957 2.97484706931026e-12 NA NA NA hsa-miR-362-3p TGFB2 2.0756816987665 3.89026064579331e-12 -1.19931727990522 0.00330886829654418 miRanda -0.218398256631292 0.00107142313440827 NA NA NA hsa-miR-362-5p TGFB2 1.59303749908759 9.582675908797e-08 -1.19931727990522 0.00330886829654418 MirTarget -0.222085312260446 0.000683040393757458 NA NA NA hsa-miR-429 TGFB2 4.48815175680773 2.44117492218206e-17 -1.19931727990522 0.00330886829654418 miRNATAP -0.354478665199625 1.01610694076904e-25 NA NA NA hsa-miR-454-3p TGFB2 2.47234127820054 1.12878018736016e-21 -1.19931727990522 0.00330886829654418 MirTarget;miRNATAP -0.36249217687122 1.13442108861214e-06 NA NA NA hsa-miR-500a-5p TGFB2 1.72110365584658 3.0807246212659e-10 -1.19931727990522 0.00330886829654418 mirMAP -0.230492171637341 0.0012015489418391 NA NA NA hsa-miR-500b-5p TGFB2 1.72172606292185 3.06592098153205e-10 -1.19931727990522 0.00330886829654418 MirTarget -0.231076703558946 0.00116359223151538 NA NA NA hsa-miR-590-3p TGFB2 2.59289455139753 1.03200520972022e-21 -1.19931727990522 0.00330886829654418 mirMAP -0.266142801996328 0.000194961333085026 NA NA NA hsa-miR-590-5p TGFB2 3.18300989862077 2.06813568597893e-26 -1.19931727990522 0.00330886829654418 miRanda;miRNATAP -0.324271064441974 3.01832441227307e-07 NA NA NA hsa-miR-944 TGFB2 2.91186649218281 1.31574753528144e-06 -1.19931727990522 0.00330886829654418 mirMAP -0.180206577855112 5.25792273122866e-08 NA NA NA hsa-let-7a-3p TGFB3 1.42015538786275 7.03375209382654e-13 -1.92191802151593 4.13522948700016e-07 MirTarget -0.381916955776687 3.24138794334629e-05 NA NA NA hsa-miR-10a-5p TGFB3 1.15016989191194 0.00372037233992369 -1.92191802151593 4.13522948700016e-07 miRNAWalker2_validate -0.418366510356312 7.09740564892359e-21 NA NA NA hsa-miR-151a-5p TGFB3 2.32422038747303 2.66226949101065e-18 -1.92191802151593 4.13522948700016e-07 MirTarget -0.825941146129225 4.42377138616228e-42 NA NA NA hsa-miR-26b-3p TGFB3 2.18464160365372 2.11543189388328e-18 -1.92191802151593 4.13522948700016e-07 MirTarget -0.677656521133706 2.42952260248002e-23 NA NA NA hsa-miR-29b-3p TGFB3 1.65828197923813 1.02676780888141e-09 -1.92191802151593 4.13522948700016e-07 miRTarBase -0.399950302957701 1.59835018316921e-09 NA NA NA hsa-miR-590-3p TGFB3 2.59289455139753 1.03200520972022e-21 -1.92191802151593 4.13522948700016e-07 miRanda -0.525346026949253 7.10585127062809e-16 NA NA NA hsa-miR-629-3p TGFB3 2.36570947321815 1.33458201201618e-11 -1.92191802151593 4.13522948700016e-07 MirTarget -0.297411694512799 3.147434114319e-07 NA NA NA hsa-let-7a-5p TGFBR1 0.618599506841644 2.76973453058748e-05 -0.531745632851025 0.0111481565689226 TargetScan;miRNATAP -0.244428925468535 0.000440383623292106 27234654 rs868 is contained in a let-7 miRNA binding site in the 3'UTR of TGFBR1 which might provide a functional basis for the association in MSS HNPCC colorectal cancer hsa-let-7b-5p TGFBR1 0.604314269683977 0.00140009936153214 -0.531745632851025 0.0111481565689226 miRNATAP -0.164395211205111 0.002334077702266 27234654 rs868 is contained in a let-7 miRNA binding site in the 3'UTR of TGFBR1 which might provide a functional basis for the association in MSS HNPCC; In luciferase assays the risk-associated allele for rs868 was associated with half the luciferase expression in the presence of miRNA let-7b-5p compared with protective allele suggesting more binding of let-7b-5p and less TGFBR1 expression colorectal cancer hsa-let-7d-5p TGFBR1 1.33236798905207 1.1741085658466e-13 -0.531745632851025 0.0111481565689226 miRNAWalker2_validate;miRNATAP -0.249677273322744 5.91436156062502e-06 NA NA NA hsa-let-7e-5p TGFBR1 0.860104282510173 6.04758298373779e-05 -0.531745632851025 0.0111481565689226 miRNATAP -0.165779353656999 0.000445651685953496 NA NA NA hsa-let-7f-5p TGFBR1 0.495648727272215 0.00355972741198794 -0.531745632851025 0.0111481565689226 miRNATAP -0.212539435969951 0.000421071580866339 NA NA NA hsa-let-7g-5p TGFBR1 1.20061455355116 1.50237505511483e-12 -0.531745632851025 0.0111481565689226 miRNATAP -0.498242721643013 1.58222259474873e-18 NA NA NA hsa-miR-101-3p TGFBR1 0.522819989585461 0.00375627731618038 -0.531745632851025 0.0111481565689226 miRNAWalker2_validate;miRNATAP -0.356084641759078 1.678272043475e-10 NA NA NA hsa-miR-126-5p TGFBR1 0.895338176458417 2.33372756450713e-05 -0.531745632851025 0.0111481565689226 mirMAP;miRNATAP -0.153123735128566 0.00137633400200009 NA NA NA hsa-miR-128-3p TGFBR1 1.63756041666078 6.79626586407187e-14 -0.531745632851025 0.0111481565689226 miRNAWalker2_validate;miRTarBase -0.248098643403413 2.90608464652714e-08 NA NA NA hsa-miR-130b-3p TGFBR1 3.5350292994509 1.73934183852569e-27 -0.531745632851025 0.0111481565689226 miRNATAP -0.134668437053487 3.34039315804437e-06 NA NA NA hsa-miR-16-2-3p TGFBR1 2.31623086727196 4.29838149388188e-20 -0.531745632851025 0.0111481565689226 mirMAP -0.118014665876922 0.00216991899384218 NA NA NA hsa-miR-181c-5p TGFBR1 1.58587920618301 1.57506918816933e-10 -0.531745632851025 0.0111481565689226 mirMAP;miRNATAP -0.16918051477343 2.32913877572708e-05 NA NA NA hsa-miR-186-5p TGFBR1 1.47445398888668 3.0781726595413e-15 -0.531745632851025 0.0111481565689226 mirMAP -0.261901522962087 6.15270096138054e-07 NA NA NA hsa-miR-200b-3p TGFBR1 3.78235093249346 3.18343003239465e-14 -0.531745632851025 0.0111481565689226 mirMAP -0.185163040320424 3.55754064059769e-23 20498632 Inhibition of TGFbeta receptor 1 TGFBR1 in these cells induced MET and reduction of prometastatic miR-21 but caused an increase of the miR-200 family thyroid cancer hsa-miR-2110 TGFBR1 1.16625590651194 6.4784195289885e-05 -0.531745632851025 0.0111481565689226 miRNATAP -0.203122265430452 3.02839928126399e-08 NA NA NA hsa-miR-301a-3p TGFBR1 2.81024345929638 2.29784847962242e-17 -0.531745632851025 0.0111481565689226 miRNATAP -0.188558650494062 6.94428278524489e-10 NA NA NA hsa-miR-32-3p TGFBR1 2.02436999565685 5.94091197945307e-09 -0.531745632851025 0.0111481565689226 mirMAP;miRNATAP -0.116207615183923 0.000365699800115398 NA NA NA hsa-miR-3200-3p TGFBR1 2.70510522077868 1.90469509928484e-08 -0.531745632851025 0.0111481565689226 miRNATAP -0.120700105473579 2.69621919466987e-08 NA NA NA hsa-miR-320a TGFBR1 0.438165828017084 0.0390159073347133 -0.531745632851025 0.0111481565689226 PITA;miRanda;miRNATAP -0.326176915517583 4.1064210958607e-12 NA NA NA hsa-miR-320b TGFBR1 1.55692969039548 1.41071034251915e-08 -0.531745632851025 0.0111481565689226 PITA;miRanda;miRNATAP -0.191128801910238 1.11537638054288e-07 NA NA NA hsa-miR-330-3p TGFBR1 0.876747334239085 0.00073709016089703 -0.531745632851025 0.0111481565689226 mirMAP;miRNATAP -0.231238826647919 1.69019842696319e-09 NA NA NA hsa-miR-331-3p TGFBR1 2.28379581858927 1.99663919173155e-18 -0.531745632851025 0.0111481565689226 PITA;miRNATAP -0.227588969955072 5.92157067223612e-10 NA NA NA hsa-miR-361-5p TGFBR1 0.971859117235239 5.30236555707088e-09 -0.531745632851025 0.0111481565689226 miRanda;mirMAP;miRNATAP -0.327512599032841 4.9385335452745e-08 NA NA NA hsa-miR-374a-5p TGFBR1 0.484615721953736 0.0042981729815149 -0.531745632851025 0.0111481565689226 mirMAP -0.1725550403971 0.00437986725180039 NA NA NA hsa-miR-429 TGFBR1 4.48815175680773 2.44117492218206e-17 -0.531745632851025 0.0111481565689226 miRanda;miRNATAP -0.169764852224625 2.30995613689702e-22 NA NA NA hsa-miR-454-3p TGFBR1 2.47234127820054 1.12878018736016e-21 -0.531745632851025 0.0111481565689226 mirMAP;miRNATAP -0.205677505304361 6.16209314820036e-08 NA NA NA hsa-miR-500a-5p TGFBR1 1.72110365584658 3.0807246212659e-10 -0.531745632851025 0.0111481565689226 mirMAP -0.111391945877042 0.0022402772038843 NA NA NA hsa-miR-576-5p TGFBR1 2.20467023993664 3.4053475193793e-19 -0.531745632851025 0.0111481565689226 mirMAP -0.201284779052 2.74992936654638e-07 NA NA NA hsa-miR-589-3p TGFBR1 2.51971841868825 2.39125940264107e-11 -0.531745632851025 0.0111481565689226 mirMAP -0.104859492543737 0.000438540974273448 NA NA NA hsa-miR-590-3p TGFBR1 2.59289455139753 1.03200520972022e-21 -0.531745632851025 0.0111481565689226 PITA;miRanda;mirMAP;miRNATAP -0.139228339501584 0.000139021577037225 NA NA NA hsa-miR-590-5p TGFBR1 3.18300989862077 2.06813568597893e-26 -0.531745632851025 0.0111481565689226 PITA;miRanda -0.158386241001983 1.04882834086946e-06 NA NA NA hsa-miR-664a-3p TGFBR1 0.634721925861133 0.00520070178640421 -0.531745632851025 0.0111481565689226 mirMAP -0.321621318973717 1.70943055444078e-13 NA NA NA hsa-miR-769-5p TGFBR1 1.82023760596845 9.6815886564134e-14 -0.531745632851025 0.0111481565689226 PITA;miRNATAP -0.228524293799953 9.85398652877069e-09 NA NA NA hsa-miR-944 TGFBR1 2.91186649218281 1.31574753528144e-06 -0.531745632851025 0.0111481565689226 PITA;mirMAP -0.104949150832685 4.75355134217921e-10 NA NA NA hsa-miR-96-5p TGFBR1 4.89433085814374 1.92000659886961e-31 -0.531745632851025 0.0111481565689226 TargetScan;miRNATAP -0.138876787398621 7.90055950171446e-10 NA NA NA hsa-miR-98-5p TGFBR1 1.11154309866014 1.24143909012085e-08 -0.531745632851025 0.0111481565689226 miRNAWalker2_validate -0.401926180925558 8.43130029155261e-16 NA NA NA hsa-miR-106a-5p TGFBR2 2.48882002962836 1.99757727374521e-12 -1.5612933795263 2.09571393414153e-11 miRTarBase;miRNATAP -0.174237668172683 2.7024970040951e-08 22912877 MiR-106a inhibits the expression of transforming growth factor-β receptor 2 TGFBR2 leading to increased CRC cell migration and invasion cell migration colorectal cancer hsa-miR-106b-5p TGFBR2 2.46782146831112 1.36171495805632e-23 -1.5612933795263 2.09571393414153e-11 miRNATAP -0.446340567749987 1.4640429348369e-26 NA NA NA hsa-miR-107 TGFBR2 1.30977326593435 1.30372468603965e-11 -1.5612933795263 2.09571393414153e-11 miRanda;miRNATAP -0.33082940368913 1.15759545655126e-08 NA NA NA hsa-miR-130a-3p TGFBR2 2.02021855058359 1.26427102520415e-11 -1.5612933795263 2.09571393414153e-11 miRNATAP -0.187222356261558 5.74404160623046e-07 NA NA NA hsa-miR-130b-3p TGFBR2 3.5350292994509 1.73934183852569e-27 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate;miRNATAP -0.279678154840768 1.9762101701233e-18 25024357 Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC lung squamous cell cancer hsa-miR-17-5p TGFBR2 3.2710598467455 9.93128340539455e-27 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.302277707820119 6.79145607037112e-19 25011053;27120811 We demonstrate that miR-17 overexpression interferes with the TGFβ-EMT axis and hinders RCC sphere formation; and validated TGFBR2 as a direct and biologically relevant target during this process;MiR-17-5p was found to bind to the 3'UTR of TGFBR2 mRNA and further validation of this specific binding was performed through a reporter assay; An inverse correlation between miR-17-5p and TGFBR2 protein was observed in gastric cancer tissues; Cell studies revealed that miR-17-5p negatively regulated TGFBR2 expression by directly binding to the 3'UTR of TGFBR2 mRNA thereby promoting cell growth and migration; The results of our study suggest a novel regulatory network in gastric cancer mediated by miR-17-5p and TGFBR2 and may indicate that TGFBR2 could serve as a new therapeutic target in gastric cancer ; kidney renal cell cancer;gastric cancer hsa-miR-186-5p TGFBR2 1.47445398888668 3.0781726595413e-15 -1.5612933795263 2.09571393414153e-11 miRNATAP -0.383453901935314 9.23917606419292e-11 NA NA NA hsa-miR-18a-5p TGFBR2 3.78535678765353 3.72446596213886e-26 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate -0.25381972833671 2.41323249210829e-16 NA NA NA hsa-miR-19a-3p TGFBR2 3.42309334186656 3.02671914353412e-28 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate;miRNATAP -0.277232207383645 1.48488496649533e-16 NA NA NA hsa-miR-19b-3p TGFBR2 2.49529833021187 1.57028265846699e-23 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate;miRNATAP -0.351923320676886 1.03809079896527e-16 NA NA NA hsa-miR-20a-5p TGFBR2 3.15577933619191 4.19753346442454e-25 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate;miRTarBase;miRNATAP -0.29433840605417 1.11976352607645e-17 NA NA NA hsa-miR-20b-5p TGFBR2 2.07706563022469 1.10107236083433e-05 -1.5612933795263 2.09571393414153e-11 miRNATAP -0.105991731825053 9.98951097559816e-06 NA NA NA hsa-miR-21-5p TGFBR2 2.73773305747971 1.38864982139576e-43 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate;miRTarBase;miRNATAP -0.1959869038848 0.000202473977886908 24037531 Androgen receptor and microRNA 21 axis downregulates transforming growth factor beta receptor II TGFBR2 expression in prostate cancer; Our results revealed that miR-21 suppresses TGFBR2 levels by binding to its 3'-UTR and AR signaling further potentiates this effect in both untransformed and transformed human prostate epithelial cells as well as in human prostate cancers; Manipulation of androgen signaling or the expression levels of AR or miR-21 negatively altered TGFBR2 expression in untransformed and transformed human prostate epithelial cells human prostate cancer xenografts and mouse prostate glands; Together these results suggest that the AR and miR-21 axis exerts its oncogenic effects in prostate tumors by downregulating TGFBR2 hence inhibiting the tumor-suppressive activity of TGFβ pathway prostate cancer hsa-miR-29b-2-5p TGFBR2 0.910668640983475 0.00666655585493488 -1.5612933795263 2.09571393414153e-11 mirMAP -0.106614907621936 0.00190433915326164 NA NA NA hsa-miR-301a-3p TGFBR2 2.81024345929638 2.29784847962242e-17 -1.5612933795263 2.09571393414153e-11 miRNATAP -0.303245579782603 4.36341401740489e-19 25551793 MicroRNA 301a promotes migration and invasion by targeting TGFBR2 in human colorectal cancer; TGFBR2 was identified to be the downstream target of miR-301a; Knockdown of TGFBR2 in cells treated by miR-301a inhibitor elevated the previously abrogated migration and invasion; Our data indicated that miR-301a correlated with the metastatic and invasive ability in human colorectal cancers and miR-301a exerted its role as oncogene by targeting TGFBR2 colorectal cancer hsa-miR-320a TGFBR2 0.438165828017084 0.0390159073347133 -1.5612933795263 2.09571393414153e-11 miRanda;miRNATAP -0.147256255771787 0.0072521693939925 NA NA NA hsa-miR-320b TGFBR2 1.55692969039548 1.41071034251915e-08 -1.5612933795263 2.09571393414153e-11 miRanda;miRNATAP -0.259785049714809 1.72104577406335e-10 NA NA NA hsa-miR-335-3p TGFBR2 3.08791651139852 5.31309869723517e-12 -1.5612933795263 2.09571393414153e-11 mirMAP -0.116451466105744 2.86501897855708e-06 NA NA NA hsa-miR-335-5p TGFBR2 1.77247705492746 2.22457658872091e-06 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate -0.108328975461909 0.000362366652132911 NA NA NA hsa-miR-33a-3p TGFBR2 1.72765312072219 1.51784443453521e-07 -1.5612933795263 2.09571393414153e-11 mirMAP -0.218324746449326 5.80693592871469e-09 NA NA NA hsa-miR-429 TGFBR2 4.48815175680773 2.44117492218206e-17 -1.5612933795263 2.09571393414153e-11 miRNATAP -0.182453703283022 7.13137317316041e-20 NA NA NA hsa-miR-454-3p TGFBR2 2.47234127820054 1.12878018736016e-21 -1.5612933795263 2.09571393414153e-11 miRNATAP -0.334757039971147 2.96928366293251e-15 NA NA NA hsa-miR-501-3p TGFBR2 1.83132758513743 1.10971547702065e-10 -1.5612933795263 2.09571393414153e-11 TargetScan -0.239042838968307 1.06476001924321e-09 NA NA NA hsa-miR-508-3p TGFBR2 1.05493034310846 0.0393857095042515 -1.5612933795263 2.09571393414153e-11 miRNATAP -0.119214194503115 1.55583026735658e-07 NA NA NA hsa-miR-590-3p TGFBR2 2.59289455139753 1.03200520972022e-21 -1.5612933795263 2.09571393414153e-11 miRanda -0.298641027773627 2.0141780556407e-13 NA NA NA hsa-miR-590-5p TGFBR2 3.18300989862077 2.06813568597893e-26 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate;miRTarBase;PITA;miRanda;miRNATAP -0.294796030766598 2.66958610835318e-16 NA NA NA hsa-miR-9-5p TGFBR2 1.02304182473283 0.042901377604859 -1.5612933795263 2.09571393414153e-11 miRNATAP -0.120425377888386 8.76751437160767e-08 25024357 Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC lung squamous cell cancer hsa-miR-92a-3p TGFBR2 2.06460102658973 1.44784291084757e-19 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate -0.402171657787311 8.61853387794715e-18 NA NA NA hsa-miR-93-5p TGFBR2 3.03961860136032 1.11672209617395e-24 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate;miRNATAP -0.345215781740609 4.92958365930485e-23 NA NA NA hsa-miR-203a-3p TNF 3.12352008343999 9.49391438647189e-07 0.168287325738871 0.711715304997615 miRTarBase -0.111842196318691 0.000983994485349752 NA NA NA hsa-miR-320a TNF 0.438165828017084 0.0390159073347133 0.168287325738871 0.711715304997615 miRanda -0.394855461451853 0.0001481103227567 NA NA NA hsa-miR-361-5p TNF 0.971859117235239 5.30236555707088e-09 0.168287325738871 0.711715304997615 miRanda -0.363396990950332 0.00589234482466197 NA NA NA hsa-miR-429 TNF 4.48815175680773 2.44117492218206e-17 0.168287325738871 0.711715304997615 miRNATAP -0.169293563460319 1.87983425787946e-05 NA NA NA hsa-miR-222-3p TP53 0.851783756239071 0.00266783568486918 0.17313275059387 0.48779406985331 miRNAWalker2_validate -0.116904656132339 0.00589565055970469 NA NA NA