miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-107 ACVR1 1.49443409571439 0.000130594521065411 -0.764724776821659 0.0438868126863281 miRanda -0.125887519879979 0.0228848814777652 NA NA NA hsa-miR-142-3p ACVR1 4.35304505457969 3.10014573651358e-10 -0.764724776821659 0.0438868126863281 miRanda -0.172852838404982 4.63924834277727e-09 NA NA NA hsa-miR-148b-3p ACVR1 1.75622244535669 8.84414356040579e-08 -0.764724776821659 0.0438868126863281 MirTarget -0.319622886255051 7.58896425406712e-07 NA NA NA hsa-miR-16-2-3p ACVR1 3.79845098071094 1.49120139344659e-13 -0.764724776821659 0.0438868126863281 mirMAP -0.11880854807492 0.00314941500903322 NA NA NA hsa-miR-186-5p ACVR1 0.445443449112564 0.185447310527704 -0.764724776821659 0.0438868126863281 miRNAWalker2_validate -0.299272079307512 3.58485999458496e-06 NA NA NA hsa-miR-197-3p ACVR1 1.23723883665376 0.0073292027020411 -0.764724776821659 0.0438868126863281 miRNAWalker2_validate -0.105952833384726 0.0237414019775754 NA NA NA hsa-miR-19b-3p ACVR1 1.67581705793313 0.000858910586302716 -0.764724776821659 0.0438868126863281 miRNAWalker2_validate -0.16301819600189 0.000121791619431487 NA NA NA hsa-miR-30b-5p ACVR1 0.0238659735605804 0.953223658270319 -0.764724776821659 0.0438868126863281 MirTarget -0.17035386927547 0.00144204580990362 NA NA NA hsa-miR-30c-5p ACVR1 0.38723991118075 0.348605235643473 -0.764724776821659 0.0438868126863281 MirTarget;miRNATAP -0.172942931996027 0.000999505213029316 NA NA NA hsa-miR-30d-5p ACVR1 0.302504510257496 0.380193536606962 -0.764724776821659 0.0438868126863281 MirTarget;miRNATAP -0.135526542294846 0.0338073131299299 NA NA NA hsa-miR-30e-5p ACVR1 0.780047227271616 0.0346714425913016 -0.764724776821659 0.0438868126863281 MirTarget -0.289901156255877 6.44315458744234e-07 NA NA NA hsa-miR-320a ACVR1 -0.912036444869976 0.0565555443926988 -0.764724776821659 0.0438868126863281 miRanda -0.131608474562726 0.00356300072233225 NA NA NA hsa-miR-338-3p ACVR1 0.447551118940466 0.558485097370031 -0.764724776821659 0.0438868126863281 MirTarget;PITA;miRanda;miRNATAP -0.112641819426467 5.38951169521245e-05 NA NA NA hsa-miR-362-3p ACVR1 0.679952485897744 0.226148468488576 -0.764724776821659 0.0438868126863281 miRanda -0.143373806608195 0.000183139629382229 NA NA NA hsa-miR-454-3p ACVR1 1.40269869979902 0.00366085847011367 -0.764724776821659 0.0438868126863281 MirTarget;miRNATAP -0.122567492407184 0.00598777141747361 NA NA NA hsa-miR-590-3p ACVR1 2.35429565068338 2.79601879608564e-06 -0.764724776821659 0.0438868126863281 miRanda -0.213928432421181 2.87018618272604e-07 NA NA NA hsa-let-7d-5p ACVR1C 0.831142050231414 0.0126955498524287 1.69358470328878 0.118696484182973 MirTarget;miRNATAP -0.371336403983045 0.0493624582879621 NA NA NA hsa-let-7e-5p ACVR1C -0.111012524740586 0.814744515884005 1.69358470328878 0.118696484182973 MirTarget;miRNATAP -0.526388663406781 5.39996367642266e-05 NA NA NA hsa-let-7g-5p ACVR1C 0.857251702023746 0.00647597344297273 1.69358470328878 0.118696484182973 MirTarget;miRNATAP -0.477932486113053 0.0170541516919522 NA NA NA hsa-miR-129-5p ACVR1C -2.66843722411409 0.00695783358331245 1.69358470328878 0.118696484182973 miRanda -0.176558357357172 0.00497788706986173 NA NA NA hsa-miR-130a-5p ACVR1C 1.58028512890005 0.024346333013728 1.69358470328878 0.118696484182973 miRNATAP -0.283702911585428 0.00143520521462514 NA NA NA hsa-miR-181b-5p ACVR1C 1.11397227523501 0.0273417050354018 1.69358470328878 0.118696484182973 miRNATAP -0.309360477736448 0.0116556742362251 NA NA NA hsa-miR-181c-5p ACVR1C -0.302833440762172 0.537532549455539 1.69358470328878 0.118696484182973 miRNATAP -0.28007699326565 0.0271446780471679 NA NA NA hsa-miR-26b-5p ACVR1C 0.314414148564179 0.461628303578321 1.69358470328878 0.118696484182973 MirTarget;miRNATAP -0.306419146406598 0.0364255571848354 NA NA NA hsa-miR-335-3p ACVR1C 1.19503568251824 0.0938852560631551 1.69358470328878 0.118696484182973 MirTarget -0.174687342227282 0.0435764325104022 NA NA NA hsa-miR-7-1-3p ACVR1C 1.43074343339835 0.00471215970502094 1.69358470328878 0.118696484182973 mirMAP -0.2582450322942 0.034526630951187 NA NA NA hsa-let-7i-5p ACVR2A 0.0473185312396307 0.869714142234765 -0.445065558149398 0.276091557573621 miRNATAP -0.207079520090979 0.0125640684340953 NA NA NA hsa-miR-142-3p ACVR2A 4.35304505457969 3.10014573651358e-10 -0.445065558149398 0.276091557573621 MirTarget;PITA;miRanda;miRNATAP -0.11373526951566 0.000425474664105896 NA NA NA hsa-miR-181a-5p ACVR2A 1.25558293560636 0.00748975499703878 -0.445065558149398 0.276091557573621 MirTarget;miRNATAP -0.104421444220041 0.0349078591194672 NA NA NA hsa-miR-193b-5p ACVR2A 0.448438597554777 0.565875535989548 -0.445065558149398 0.276091557573621 MirTarget -0.127241351706988 1.40836327276366e-05 NA NA NA hsa-miR-21-5p ACVR2A 2.65163477806992 6.72089787690756e-16 -0.445065558149398 0.276091557573621 miRNATAP -0.240840909377618 0.000401712397836834 NA NA NA hsa-miR-27a-3p ACVR2A 1.76094007417453 0.000216137556256765 -0.445065558149398 0.276091557573621 miRNATAP -0.137083224856059 0.00462635846190231 NA NA NA hsa-miR-29a-3p ACVR2A -0.638239697975974 0.251923581881716 -0.445065558149398 0.276091557573621 miRNATAP -0.177427149767841 1.71531401479103e-05 NA NA NA hsa-miR-29a-5p ACVR2A 0.0748295222568571 0.884125894063293 -0.445065558149398 0.276091557573621 mirMAP;miRNATAP -0.207760139267172 3.52568750633372e-06 NA NA NA hsa-miR-29b-3p ACVR2A 0.666547117072858 0.234055379278093 -0.445065558149398 0.276091557573621 miRNATAP -0.184897401721193 6.41112984142575e-06 NA NA NA hsa-miR-331-5p ACVR2A 1.02712086964089 0.0262526092356277 -0.445065558149398 0.276091557573621 PITA -0.109522149160177 0.0297559757600178 NA NA NA hsa-let-7b-3p ACVR2B 0.589364128513318 0.200507534602851 -0.465773014962998 0.347299892011966 MirTarget -0.228531189240534 0.000185124223183222 NA NA NA hsa-let-7f-1-3p ACVR2B 1.61507869803314 0.00069342464777815 -0.465773014962998 0.347299892011966 MirTarget -0.196322516424578 0.000876968490228771 NA NA NA hsa-miR-142-5p ACVR2B 3.95552531913424 1.49536283724079e-08 -0.465773014962998 0.347299892011966 PITA -0.173339765985091 7.86351099002201e-06 NA NA NA hsa-miR-342-5p ACVR2B 1.3865615438184 0.0153598969109545 -0.465773014962998 0.347299892011966 miRNATAP -0.180372232758672 0.000217363334100315 NA NA NA hsa-miR-455-3p ACVR2B 2.1864857056272 0.00137304627957677 -0.465773014962998 0.347299892011966 miRNATAP -0.138020916274632 0.000685269147463274 NA NA NA hsa-miR-455-5p ACVR2B -0.317715589860275 0.616296031007863 -0.465773014962998 0.347299892011966 PITA -0.160562082356719 0.000275840585572924 NA NA NA hsa-let-7a-5p BMP2 0.148081801547773 0.645305441523746 0.595740898970527 0.596139083918881 TargetScan -0.42600513523593 0.0366775047671551 NA NA NA hsa-miR-106a-5p BMP2 3.98693608217557 9.37722470816656e-07 0.595740898970527 0.596139083918881 miRNATAP -0.284756722505656 0.000196543267629134 NA NA NA hsa-miR-362-3p BMP2 0.679952485897744 0.226148468488576 0.595740898970527 0.596139083918881 miRanda -0.390686913840248 0.000600723221602875 NA NA NA hsa-miR-378c BMP2 0.449601775771001 0.4993814483956 0.595740898970527 0.596139083918881 miRNATAP -0.281129605798991 0.00340183029023861 NA NA NA hsa-miR-429 BMP2 6.39965293994036 1.96920201593608e-18 0.595740898970527 0.596139083918881 miRNATAP -0.316552444908905 0.000105772353880714 NA NA NA hsa-miR-142-3p BMP4 4.35304505457969 3.10014573651358e-10 -1.94703268163709 0.0822008874653257 PITA;miRanda -0.375958312329309 2.16964863280377e-05 NA NA NA hsa-miR-590-3p BMP4 2.35429565068338 2.79601879608564e-06 -1.94703268163709 0.0822008874653257 miRanda -0.369298014297492 0.00319363636714979 NA NA NA hsa-miR-125a-3p BMP7 -0.0748960586927341 0.920735897434087 2.47007870640865 0.141831667873887 miRanda -0.602397019762289 1.60854190307016e-06 NA NA NA hsa-miR-30a-5p BMP7 -0.768430903969183 0.320487552854215 2.47007870640865 0.141831667873887 mirMAP;miRNATAP -0.837637094666436 2.22227369883976e-12 NA NA NA hsa-miR-338-3p BMP7 0.447551118940466 0.558485097370031 2.47007870640865 0.141831667873887 miRanda -0.675850252283759 3.5099234776835e-08 NA NA NA hsa-miR-616-5p BMP7 2.48416313933027 0.00318247475868827 2.47007870640865 0.141831667873887 mirMAP -0.305709380897436 0.0309538280482594 NA NA NA hsa-miR-142-3p BMP8A 4.35304505457969 3.10014573651358e-10 -0.908883846447831 0.149406718545684 miRNAWalker2_validate -0.151623785619638 0.0024673264370693 NA NA NA hsa-miR-30e-3p BMP8A -0.0362193022195196 0.932577027239525 -0.908883846447831 0.149406718545684 MirTarget -0.272991487072419 0.00121157832661015 NA NA NA hsa-miR-326 BMP8A 1.76645822596029 0.0367310428720192 -0.908883846447831 0.149406718545684 miRanda -0.120244523761685 0.00459378828407528 NA NA NA hsa-miR-330-5p BMP8A 2.25110496739954 0.000275527655397415 -0.908883846447831 0.149406718545684 miRanda -0.141064278836011 0.0139965406922921 NA NA NA hsa-miR-423-5p BMP8A 0.227366878624794 0.5653498335202 -0.908883846447831 0.149406718545684 MirTarget -0.183678196894596 0.0460179597781925 NA NA NA hsa-miR-125a-3p BMP8B -0.0748960586927341 0.920735897434087 2.55233654308544 0.000406125109313419 miRanda -0.132890299961019 0.0157961128424701 NA NA NA hsa-miR-125a-5p BMP8B -1.32352790615388 0.00714301627309467 2.55233654308544 0.000406125109313419 miRanda -0.21763357986147 0.00972666932519359 NA NA NA hsa-miR-150-5p BMP8B 1.76769157530064 0.0593795975117846 2.55233654308544 0.000406125109313419 mirMAP -0.101569952393627 0.020776607076679 NA NA NA hsa-miR-181a-5p BMP8B 1.25558293560636 0.00748975499703878 2.55233654308544 0.000406125109313419 mirMAP -0.174411820910534 0.0488363550243845 NA NA NA hsa-miR-181b-5p BMP8B 1.11397227523501 0.0273417050354018 2.55233654308544 0.000406125109313419 mirMAP -0.194068988394633 0.0182517761069697 NA NA NA hsa-miR-181c-5p BMP8B -0.302833440762172 0.537532549455539 2.55233654308544 0.000406125109313419 mirMAP -0.178337622034896 0.0358007082300119 NA NA NA hsa-miR-26b-5p BMP8B 0.314414148564179 0.461628303578321 2.55233654308544 0.000406125109313419 miRNAWalker2_validate -0.338787540773238 0.000511841503220318 NA NA NA hsa-miR-455-5p BMP8B -0.317715589860275 0.616296031007863 2.55233654308544 0.000406125109313419 miRanda -0.189702790864636 0.00364777683255093 NA NA NA hsa-miR-942-5p BMPR1A 3.36242661558642 1.89848306955335e-10 -1.11691578284957 0.0207420280657074 MirTarget -0.115821943076165 0.0223255431579815 NA NA NA hsa-miR-142-5p BMPR1B 3.95552531913424 1.49536283724079e-08 -1.52134988166544 0.343393213784145 mirMAP -0.734195251953472 3.70209244281447e-09 NA NA NA hsa-miR-146b-5p BMPR1B 1.87569569182453 0.000737241069698886 -1.52134988166544 0.343393213784145 miRanda -0.666457773194095 3.90750084541049e-05 NA NA NA hsa-miR-150-5p BMPR1B 1.76769157530064 0.0593795975117846 -1.52134988166544 0.343393213784145 MirTarget -0.474315918794335 6.64615777439564e-07 NA NA NA hsa-miR-205-5p BMPR1B 8.08298115900323 3.83045179398654e-07 -1.52134988166544 0.343393213784145 miRNATAP -0.30696104798101 2.09869521416875e-08 NA NA NA hsa-miR-23a-3p BMPR1B 0.925125296618358 0.0127293543936914 -1.52134988166544 0.343393213784145 mirMAP -0.604519323094653 0.0151563609476042 NA NA NA hsa-miR-23b-3p BMPR1B -0.581135273821923 0.190478897170459 -1.52134988166544 0.343393213784145 mirMAP -0.738278706558228 0.000346932652828484 NA NA NA hsa-miR-24-3p BMPR1B 1.55853749533999 0.000524726461381821 -1.52134988166544 0.343393213784145 miRNATAP -0.553792517791316 0.00634597891344123 NA NA NA hsa-miR-374a-5p BMPR1B 0.278549982012055 0.45888283715888 -1.52134988166544 0.343393213784145 MirTarget -0.875519236735069 0.000361012347481395 NA NA NA hsa-miR-590-3p BMPR1B 2.35429565068338 2.79601879608564e-06 -1.52134988166544 0.343393213784145 miRanda;mirMAP -0.552426048195125 0.00204524961517634 NA NA NA hsa-miR-629-3p BMPR1B 3.48282157979573 4.9176538695908e-08 -1.52134988166544 0.343393213784145 MirTarget -0.416162287016012 0.00285439024103792 NA NA NA hsa-let-7a-3p BMPR2 0.82512001802525 0.0468122405194487 -1.12630218798609 0.00109088044133536 MirTarget;miRNATAP -0.114706586890353 0.0164442212871709 NA NA NA hsa-let-7f-1-3p BMPR2 1.61507869803314 0.00069342464777815 -1.12630218798609 0.00109088044133536 MirTarget -0.123298671912875 0.00285602396296033 NA NA NA hsa-miR-106b-5p BMPR2 2.80565545918114 1.14547999022566e-09 -1.12630218798609 0.00109088044133536 MirTarget;miRNATAP -0.118630186532809 0.0044306068125726 NA NA NA hsa-miR-146b-3p BMPR2 1.34608871980101 0.00935728391852709 -1.12630218798609 0.00109088044133536 MirTarget;PITA -0.129887166168285 0.0005867601546192 NA NA NA hsa-miR-148b-3p BMPR2 1.75622244535669 8.84414356040579e-08 -1.12630218798609 0.00109088044133536 mirMAP -0.196466429101429 0.000987067706586972 NA NA NA hsa-miR-16-2-3p BMPR2 3.79845098071094 1.49120139344659e-13 -1.12630218798609 0.00109088044133536 mirMAP -0.146205885014432 6.2092491962501e-05 NA NA NA hsa-miR-17-5p BMPR2 2.3269271449522 2.13987445663942e-05 -1.12630218798609 0.00109088044133536 miRNAWalker2_validate;MirTarget;TargetScan;miRNATAP -0.123193636647238 0.000494673489159658 NA NA NA hsa-miR-19b-3p BMPR2 1.67581705793313 0.000858910586302716 -1.12630218798609 0.00109088044133536 miRNAWalker2_validate;MirTarget;miRNATAP -0.150829353350739 9.76501280448681e-05 NA NA NA hsa-miR-20a-5p BMPR2 2.13553469875764 0.000181201072324354 -1.12630218798609 0.00109088044133536 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.109933280976769 0.0012552170058051 NA NA NA hsa-miR-21-5p BMPR2 2.65163477806992 6.72089787690756e-16 -1.12630218798609 0.00109088044133536 miRNAWalker2_validate;miRTarBase;MirTarget -0.1214041231959 0.0368710131324604 NA NA NA hsa-miR-25-3p BMPR2 1.12623030168869 0.00311079344417173 -1.12630218798609 0.00109088044133536 miRNATAP -0.161936056023317 0.00181112605669761 NA NA NA hsa-miR-30b-5p BMPR2 0.0238659735605804 0.953223658270319 -1.12630218798609 0.00109088044133536 mirMAP -0.165651429980918 0.000678402541773278 NA NA NA hsa-miR-30e-5p BMPR2 0.780047227271616 0.0346714425913016 -1.12630218798609 0.00109088044133536 mirMAP -0.152650979111587 0.00461355244700787 NA NA NA hsa-miR-32-5p BMPR2 2.93035124381469 5.00149131394151e-10 -1.12630218798609 0.00109088044133536 miRNATAP -0.152990695015064 0.000157914766251291 NA NA NA hsa-miR-590-3p BMPR2 2.35429565068338 2.79601879608564e-06 -1.12630218798609 0.00109088044133536 MirTarget;miRanda;mirMAP;miRNATAP -0.180484987835457 2.26482768248502e-06 NA NA NA hsa-miR-590-5p BMPR2 1.51400888103768 0.0023888567923017 -1.12630218798609 0.00109088044133536 MirTarget;PITA;miRNATAP -0.148168305174109 0.000153211214789233 NA NA NA hsa-miR-92a-3p BMPR2 1.87892405805529 1.27013821556583e-05 -1.12630218798609 0.00109088044133536 miRNAWalker2_validate;miRNATAP -0.198526920027066 1.013641786486e-05 NA NA NA hsa-miR-93-3p BMPR2 2.62833115374128 2.28843227834337e-07 -1.12630218798609 0.00109088044133536 miRNAWalker2_validate -0.111582243298826 0.00334043843071077 NA NA NA hsa-miR-93-5p BMPR2 2.65964181833033 2.58315947526774e-08 -1.12630218798609 0.00109088044133536 miRNAWalker2_validate;MirTarget;miRNATAP -0.125581481915172 0.00184301830288687 NA NA NA hsa-miR-103a-3p CD274 0.990919087251708 0.00468308601422847 2.22279412449515 0.0516111370736547 miRNAWalker2_validate -0.483901377020577 0.010127083096146 NA NA NA hsa-miR-106a-5p CD274 3.98693608217557 9.37722470816656e-07 2.22279412449515 0.0516111370736547 MirTarget;miRNATAP -0.236984996685837 0.00244589289765692 NA NA NA hsa-miR-182-5p CD274 5.86988712704738 1.22411588571584e-15 2.22279412449515 0.0516111370736547 mirMAP -0.339706442437269 4.80944840181619e-05 NA NA NA hsa-miR-200a-3p CD274 6.336081120041 4.024313571871e-16 2.22279412449515 0.0516111370736547 MirTarget -0.349325798251526 8.24128678574652e-06 NA NA NA hsa-miR-20b-5p CD274 4.5662923200279 4.75238200639144e-05 2.22279412449515 0.0516111370736547 MirTarget;miRNATAP -0.192258791595886 0.000703899942107355 24468585 These findings suggest that miR-20b -21 and -130b up-regulated in colorectal cancer through inhibiting the expression of PTEN result in B7-H1 over-expression in colorectal cancer colorectal cancer hsa-miR-324-5p CD274 1.31253452379847 0.0116806680545163 2.22279412449515 0.0516111370736547 miRanda -0.47313482826795 0.000139757569599412 NA NA NA hsa-miR-429 CD274 6.39965293994036 1.96920201593608e-18 2.22279412449515 0.0516111370736547 miRanda -0.414756964042163 4.97744617535068e-07 NA NA NA hsa-miR-497-5p CD274 -1.44150596209372 0.0225146607606395 2.22279412449515 0.0516111370736547 MirTarget -0.383087599725002 0.000175050271995498 NA NA NA hsa-miR-93-5p CD274 2.65964181833033 2.58315947526774e-08 2.22279412449515 0.0516111370736547 MirTarget;miRNATAP -0.455113489627987 0.000638032417442551 NA NA NA hsa-miR-107 CDKN2B 1.49443409571439 0.000130594521065411 3.0483618600868 0.000209973570530815 PITA -0.451661629246362 0.000176451976452473 NA NA NA hsa-miR-125a-3p CDKN2B -0.0748960586927341 0.920735897434087 3.0483618600868 0.000209973570530815 miRanda -0.281235486977565 5.87183094847568e-06 NA NA NA hsa-miR-125a-5p CDKN2B -1.32352790615388 0.00714301627309467 3.0483618600868 0.000209973570530815 miRanda -0.607767279625756 7.34559713840635e-11 NA NA NA hsa-miR-126-5p CDKN2B -0.420466581381807 0.329972801718418 3.0483618600868 0.000209973570530815 mirMAP -0.384730895689604 0.000468547465389506 NA NA NA hsa-miR-19a-3p CDKN2B 2.17020503944519 0.00122084653711062 3.0483618600868 0.000209973570530815 mirMAP -0.141040432258969 0.0437577677669512 NA NA NA hsa-miR-19b-3p CDKN2B 1.67581705793313 0.000858910586302716 3.0483618600868 0.000209973570530815 mirMAP -0.211754835088046 0.0238928593989622 NA NA NA hsa-miR-217 CDKN2B -0.378397407994341 0.717408682071252 3.0483618600868 0.000209973570530815 miRanda -0.146340892670124 0.0011879794504395 NA NA NA hsa-miR-28-5p CDKN2B -0.815636722979196 0.0221199948901761 3.0483618600868 0.000209973570530815 miRanda -0.813818647185525 5.20786465614388e-10 NA NA NA hsa-miR-335-3p CDKN2B 1.19503568251824 0.0938852560631551 3.0483618600868 0.000209973570530815 mirMAP -0.230132652662327 0.000461918630662828 NA NA NA hsa-miR-374b-5p CDKN2B -0.114749866169918 0.764888930049438 3.0483618600868 0.000209973570530815 miRNAWalker2_validate -0.427660032295754 0.000588414390873068 NA NA NA hsa-miR-375 CDKN2B 3.3784490463318 0.0449946294355695 3.0483618600868 0.000209973570530815 miRNAWalker2_validate;miRNATAP -0.135134550270944 7.98570366612466e-07 NA NA NA hsa-miR-450b-5p CDKN2B 0.445103105471153 0.416021465008949 3.0483618600868 0.000209973570530815 mirMAP -0.269827235831244 0.00178266967612344 NA NA NA hsa-miR-495-3p CDKN2B -1.28495103468384 0.0979462503954353 3.0483618600868 0.000209973570530815 MirTarget -0.177011624965662 0.00348969353672305 NA NA NA hsa-miR-501-3p CDKN2B 1.72239979688923 0.0075900263732748 3.0483618600868 0.000209973570530815 PITA -0.382280585734888 9.20643371704555e-08 NA NA NA hsa-miR-501-5p CDKN2B 1.0411896821345 0.0777206709183552 3.0483618600868 0.000209973570530815 mirMAP -0.353195575048531 8.09502902784753e-06 NA NA NA hsa-miR-502-3p CDKN2B -0.102232623565007 0.80889202592629 3.0483618600868 0.000209973570530815 PITA -0.501828823781054 7.10109662589701e-06 NA NA NA hsa-miR-576-5p CDKN2B 1.30320223793746 0.00648929463912994 3.0483618600868 0.000209973570530815 MirTarget -0.24385227531482 0.0135759150509429 NA NA NA hsa-miR-582-5p CDKN2B 0.685177900016753 0.447761540297692 3.0483618600868 0.000209973570530815 miRNATAP -0.142565867298399 0.00622437078082883 NA NA NA hsa-miR-671-5p CDKN2B 1.48527046124636 0.00686722328347111 3.0483618600868 0.000209973570530815 PITA -0.353451371274366 3.22699968328056e-05 NA NA NA hsa-miR-7-1-3p CDKN2B 1.43074343339835 0.00471215970502094 3.0483618600868 0.000209973570530815 MirTarget -0.357518494533497 0.000112620950429957 NA NA NA hsa-let-7f-5p CHRD 0.971961126099146 0.0240319857511033 -4.86956541563963 3.90165713744332e-06 MirTarget;miRNATAP -0.339788516779306 0.0171481040668123 NA NA NA hsa-let-7g-3p CHRD 2.09736290930341 5.30067796437833e-05 -4.86956541563963 3.90165713744332e-06 MirTarget -0.2436040724261 0.0369202267768653 NA NA NA hsa-miR-21-3p CREBBP 3.50297439576639 6.39946844099206e-10 -0.3958302023172 0.180670093990074 MirTarget -0.1378273582574 1.08112070034993e-06 NA NA NA hsa-miR-590-3p CREBBP 2.35429565068338 2.79601879608564e-06 -0.3958302023172 0.180670093990074 PITA;miRanda;mirMAP;miRNATAP -0.100352894791816 0.00219317602458258 NA NA NA hsa-let-7d-5p DCN 0.831142050231414 0.0126955498524287 -5.57812539480817 9.99722934741756e-08 MirTarget -0.693674106936328 0.000170980727532721 NA NA NA hsa-let-7g-5p DCN 0.857251702023746 0.00647597344297273 -5.57812539480817 9.99722934741756e-08 MirTarget -0.508204108340296 0.00996310545099632 NA NA NA hsa-miR-3065-5p DCN 2.14185373842821 0.0609400502269891 -5.57812539480817 9.99722934741756e-08 mirMAP -0.138818256337503 0.0358238119275122 NA NA NA hsa-miR-374b-3p DCN 0.501845732983925 0.343338908602826 -5.57812539480817 9.99722934741756e-08 MirTarget -0.284282235371128 0.0147683242188491 NA NA NA hsa-miR-421 DCN 1.97624148591545 0.000915838012451138 -5.57812539480817 9.99722934741756e-08 miRanda -0.27580685200609 0.00668381401976743 NA NA NA hsa-miR-501-5p DCN 1.0411896821345 0.0777206709183552 -5.57812539480817 9.99722934741756e-08 mirMAP -0.35541924818636 0.000536225854622283 NA NA NA hsa-miR-590-3p DCN 2.35429565068338 2.79601879608564e-06 -5.57812539480817 9.99722934741756e-08 MirTarget;PITA;miRanda;mirMAP -0.417033846886242 0.000464733684797091 NA NA NA hsa-miR-7-1-3p DCN 1.43074343339835 0.00471215970502094 -5.57812539480817 9.99722934741756e-08 mirMAP -0.331009545534078 0.00582260375259807 NA NA NA hsa-let-7a-5p E2F5 0.148081801547773 0.645305441523746 -0.639266662126547 0.416174414596425 MirTarget;TargetScan;miRNATAP -0.325132871878297 0.0224852990644336 NA NA NA hsa-let-7b-5p E2F5 -0.189422992330471 0.651878220048983 -0.639266662126547 0.416174414596425 miRNAWalker2_validate;MirTarget;miRNATAP -0.276412801214816 0.0102070191276974 NA NA NA hsa-let-7f-5p E2F5 0.971961126099146 0.0240319857511033 -0.639266662126547 0.416174414596425 MirTarget;miRNATAP -0.353852840088557 0.000664150120910199 NA NA NA hsa-let-7i-5p E2F5 0.0473185312396307 0.869714142234765 -0.639266662126547 0.416174414596425 MirTarget;miRNATAP -0.494751518747998 0.00193678048367326 NA NA NA hsa-miR-1-3p E2F5 -3.85397883903804 6.93274972711165e-06 -0.639266662126547 0.416174414596425 MirTarget -0.151433993301856 0.00306193575274417 NA NA NA hsa-miR-142-3p E2F5 4.35304505457969 3.10014573651358e-10 -0.639266662126547 0.416174414596425 miRanda -0.168926633694876 0.00689492861438165 NA NA NA hsa-miR-199b-5p E2F5 -0.53728867775768 0.476885702455766 -0.639266662126547 0.416174414596425 miRanda -0.126013460892835 0.0331182843237222 NA NA NA hsa-miR-205-5p E2F5 8.08298115900323 3.83045179398654e-07 -0.639266662126547 0.416174414596425 miRNAWalker2_validate;miRTarBase;miRNATAP -0.184708069923657 2.74621532953329e-12 21454583 The expression levels of E2F1 and E2F5 were correlated inversely with that of miR-205 in melanoma cell lines; miR-205 significantly suppressed the luciferase activity of reporter plasmids containing the 3'-UTR sequences complementary to either E2F1 or E2F5; Overexpression of miR-205 in melanoma cells reduced E2F1 and E2F5 protein levels melanoma hsa-miR-34c-5p E2F5 2.64675661251039 0.0157394735757952 -0.639266662126547 0.416174414596425 MirTarget;PITA;miRanda;miRNATAP -0.157867299377243 8.51362892001314e-05 NA NA NA hsa-miR-148a-3p EP300 1.1031350648218 0.052038169812979 0.224331914964019 0.578934208058052 miRNATAP -0.104185690998739 0.00975228544208279 NA NA NA hsa-miR-26b-5p EP300 0.314414148564179 0.461628303578321 0.224331914964019 0.578934208058052 miRNAWalker2_validate;miRNATAP -0.133193686886669 0.0139568858207426 NA NA NA hsa-miR-30c-5p EP300 0.38723991118075 0.348605235643473 0.224331914964019 0.578934208058052 miRNAWalker2_validate -0.18542784496307 0.000897194160521004 NA NA NA hsa-miR-339-5p EP300 1.23326828594484 0.0307501214818698 0.224331914964019 0.578934208058052 miRanda -0.199156483102611 4.47682764951844e-07 NA NA NA hsa-miR-342-3p EP300 1.31107714473009 0.0207211910724662 0.224331914964019 0.578934208058052 MirTarget;PITA;miRanda;miRNATAP -0.115722711407846 0.00406603413994019 NA NA NA hsa-miR-361-3p EP300 0.805698609170807 0.0418491665498322 0.224331914964019 0.578934208058052 PITA -0.135942435196129 0.0200803551179427 NA NA NA hsa-miR-374b-5p EP300 -0.114749866169918 0.764888930049438 0.224331914964019 0.578934208058052 mirMAP;miRNATAP -0.159199926258203 0.00855691297646884 NA NA NA hsa-miR-590-3p EP300 2.35429565068338 2.79601879608564e-06 0.224331914964019 0.578934208058052 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.136964991854083 0.00229030845745203 NA NA NA hsa-miR-338-5p FST -0.108304629897487 0.894675560494607 0.339383376453495 0.848677738498008 MirTarget -0.456182858493687 0.000213836155315545 NA NA NA hsa-let-7g-5p GDF6 0.857251702023746 0.00647597344297273 -1.55269438174044 0.352529357077876 MirTarget;miRNATAP -0.899439728625514 0.00341856573105334 NA NA NA hsa-miR-141-3p GDF6 7.30474126597325 1.45115996357606e-24 -1.55269438174044 0.352529357077876 TargetScan -0.301334268738362 0.0138982872642358 NA NA NA hsa-miR-200b-3p GDF6 5.56167217794639 6.43540045061709e-16 -1.55269438174044 0.352529357077876 TargetScan -0.609131046562882 2.49506902870059e-06 NA NA NA hsa-miR-30a-3p GDF6 -1.22212086897848 0.167565797592104 -1.55269438174044 0.352529357077876 miRNATAP -0.228161926773645 0.0329530910063898 NA NA NA hsa-miR-30d-3p GDF6 -0.0740421896025512 0.857423650167556 -1.55269438174044 0.352529357077876 miRNATAP -0.565739990285752 0.0153716911083853 NA NA NA hsa-miR-3607-3p GDF6 1.38015131722213 0.0240067155694847 -1.55269438174044 0.352529357077876 MirTarget;miRNATAP -0.400439942474613 0.00976032234657523 NA NA NA hsa-miR-429 GDF6 6.39965293994036 1.96920201593608e-18 -1.55269438174044 0.352529357077876 PITA;miRanda;miRNATAP -0.536897304948851 9.0270313133678e-06 NA NA NA hsa-miR-532-3p GDF6 0.643755490841218 0.214842585969913 -1.55269438174044 0.352529357077876 PITA;miRNATAP -0.59653841850623 0.00112382468971625 NA NA NA hsa-miR-589-3p GDF6 1.33205316880069 0.052632683806148 -1.55269438174044 0.352529357077876 MirTarget -0.302894250812025 0.0291850731522832 NA NA NA hsa-miR-192-5p ID1 1.77716187978541 0.113485496183047 0.324775311059279 0.675429586210614 miRNAWalker2_validate -0.136145277295878 0.000450814998396788 NA NA NA hsa-miR-338-5p ID1 -0.108304629897487 0.894675560494607 0.324775311059279 0.675429586210614 MirTarget;PITA;miRNATAP -0.12259161910328 0.0233648776303904 NA NA NA hsa-let-7a-3p ID2 0.82512001802525 0.0468122405194487 -1.44903761787758 0.028108297351186 miRNATAP -0.332304595270933 0.000255934152081128 NA NA NA hsa-miR-139-5p ID2 -2.09475477693654 0.000382570602748311 -1.44903761787758 0.028108297351186 miRanda -0.170162907716332 0.00711830840129372 NA NA NA hsa-miR-27a-3p ID2 1.76094007417453 0.000216137556256765 -1.44903761787758 0.028108297351186 MirTarget;miRNATAP -0.360335443916806 3.57937005002133e-06 NA NA NA hsa-miR-320b ID2 0.20205459771295 0.727216419960509 -1.44903761787758 0.028108297351186 miRanda -0.141657358225024 0.0297816707699256 NA NA NA hsa-miR-330-3p ID2 2.49094236945806 0.000129367003214715 -1.44903761787758 0.028108297351186 MirTarget;PITA;miRNATAP -0.211998117870452 0.000199415670908787 NA NA NA hsa-miR-335-3p ID2 1.19503568251824 0.0938852560631551 -1.44903761787758 0.028108297351186 MirTarget -0.185872652315649 0.000380455687029298 NA NA NA hsa-miR-455-3p ID2 2.1864857056272 0.00137304627957677 -1.44903761787758 0.028108297351186 MirTarget;PITA;miRNATAP -0.159086590304116 0.003512126153271 NA NA NA hsa-miR-199b-5p ID3 -0.53728867775768 0.476885702455766 -1.40559952582626 0.0534907770827384 miRanda -0.157482471011185 0.00400077975763686 NA NA NA hsa-miR-3065-3p ID3 1.89496019576082 0.0308154823923145 -1.40559952582626 0.0534907770827384 miRNATAP -0.215967073130937 3.19710859005257e-06 NA NA NA hsa-miR-142-3p ID4 4.35304505457969 3.10014573651358e-10 -3.02399196922847 0.00313330221036494 miRanda -0.30254821236955 0.000206809160411308 NA NA NA hsa-miR-203a-3p ID4 6.35084246337388 7.89944323347948e-08 -3.02399196922847 0.00313330221036494 MirTarget -0.255138480807206 6.89558932429307e-08 NA NA NA hsa-miR-27a-3p ID4 1.76094007417453 0.000216137556256765 -3.02399196922847 0.00313330221036494 miRNAWalker2_validate -0.428032886588549 0.000450255785596306 NA NA NA hsa-miR-330-5p ID4 2.25110496739954 0.000275527655397415 -3.02399196922847 0.00313330221036494 miRanda -0.444975540249968 1.51075784512091e-06 NA NA NA hsa-miR-342-3p ID4 1.31107714473009 0.0207211910724662 -3.02399196922847 0.00313330221036494 MirTarget;PITA;miRanda -0.338565401869944 0.00099424882959107 24475217 miR 342 regulates BRCA1 expression through modulation of ID4 in breast cancer; To investigate at functional level the role of miR-342 in the pathogenesis of breast cancer we focused our attention on its "in silico" predicted putative target gene ID4 a transcription factor of the helix-loop-helix protein family whose expression is inversely correlated with that of ER; We functionally validated the interaction between ID4 and miR-342 in a reporter Luciferase system; Based on these findings we hypothesized that regulation of ID4 mediated by miR-342 could be involved in the pathogenesis of breast cancer by downregulating BRCA1 expression; Overexpression of miR-342 in these cells reduced ID4 and increased BRCA1 expression supporting a possible role of this mechanism in breast cancer; In the ER-positive MCF7 and in the BRCA1-mutant HCC1937 cell lines miR-342 over-expression only reduced ID4 breast cancer hsa-miR-629-3p ID4 3.48282157979573 4.9176538695908e-08 -3.02399196922847 0.00313330221036494 MirTarget -0.356897688909299 6.00540805343868e-05 NA NA NA hsa-miR-125a-5p IFNG -1.32352790615388 0.00714301627309467 3.94104665711828 0.00510150901825191 miRanda -0.637406884218199 8.76838777034272e-05 NA NA NA hsa-miR-369-3p IFNG 0.369191262196168 0.638760863212543 3.94104665711828 0.00510150901825191 PITA;miRNATAP -0.305363909941883 0.00283324153759366 NA NA NA hsa-miR-409-3p IFNG 0.293056353099264 0.67815482695354 3.94104665711828 0.00510150901825191 miRNAWalker2_validate -0.434967349237788 0.000124210543621997 NA NA NA hsa-miR-429 IFNG 6.39965293994036 1.96920201593608e-18 3.94104665711828 0.00510150901825191 miRanda -0.299498705059905 0.00377911708833624 NA NA NA hsa-miR-10a-3p INHBA 0.970411431936568 0.31667483998251 0.597174749350624 0.643310167999085 mirMAP -0.228868949828328 0.00288571997624358 NA NA NA hsa-miR-10b-5p INHBA -3.08172917642729 4.22675074435126e-09 0.597174749350624 0.643310167999085 miRNAWalker2_validate -0.375135520462904 0.00596419514318865 NA NA NA hsa-miR-125b-2-3p INHBA -1.75609980210443 0.122616157214143 0.597174749350624 0.643310167999085 mirMAP -0.157944790930006 0.0138376865661889 NA NA NA hsa-miR-148b-3p INHBA 1.75622244535669 8.84414356040579e-08 0.597174749350624 0.643310167999085 miRNAWalker2_validate -0.667439513931159 0.00272176813701307 NA NA NA hsa-miR-16-2-3p INHBA 3.79845098071094 1.49120139344659e-13 0.597174749350624 0.643310167999085 mirMAP -0.460254491787022 0.000754313391824958 NA NA NA hsa-miR-181c-5p INHBA -0.302833440762172 0.537532549455539 0.597174749350624 0.643310167999085 mirMAP -0.327187664106844 0.0295723539209472 NA NA NA hsa-miR-195-3p INHBA -2.39100534119332 0.000185405399054065 0.597174749350624 0.643310167999085 mirMAP -0.359920153494247 0.00156804274458257 NA NA NA hsa-miR-200b-3p INHBA 5.56167217794639 6.43540045061709e-16 0.597174749350624 0.643310167999085 TargetScan -0.556231875088492 1.97398662453022e-08 NA NA NA hsa-miR-224-3p INHBA 2.84876340814503 0.000179138399939161 0.597174749350624 0.643310167999085 mirMAP -0.244901176503382 0.0107132106449266 NA NA NA hsa-miR-26a-5p INHBA -0.352368463397074 0.362040749917446 0.597174749350624 0.643310167999085 mirMAP -0.482333762837731 0.0121541790978987 NA NA NA hsa-miR-3065-5p INHBA 2.14185373842821 0.0609400502269891 0.597174749350624 0.643310167999085 mirMAP -0.362079017770634 4.04665334650244e-06 NA NA NA hsa-miR-30b-5p INHBA 0.0238659735605804 0.953223658270319 0.597174749350624 0.643310167999085 mirMAP -0.641790503573834 0.00040859319409002 NA NA NA hsa-miR-30c-5p INHBA 0.38723991118075 0.348605235643473 0.597174749350624 0.643310167999085 mirMAP -0.829638986336471 2.85124185439564e-06 NA NA NA hsa-miR-30d-5p INHBA 0.302504510257496 0.380193536606962 0.597174749350624 0.643310167999085 mirMAP -0.810002974024271 0.000171793130428081 NA NA NA hsa-miR-30e-5p INHBA 0.780047227271616 0.0346714425913016 0.597174749350624 0.643310167999085 mirMAP -1.27059538225699 7.92305049877725e-11 NA NA NA hsa-miR-3607-3p INHBA 1.38015131722213 0.0240067155694847 0.597174749350624 0.643310167999085 mirMAP -0.386722991000475 0.00117665769481931 NA NA NA hsa-miR-374a-5p INHBA 0.278549982012055 0.45888283715888 0.597174749350624 0.643310167999085 mirMAP -0.531291535768356 0.00725261558931535 NA NA NA hsa-miR-374b-5p INHBA -0.114749866169918 0.764888930049438 0.597174749350624 0.643310167999085 mirMAP -0.397382374555169 0.0408507665343398 NA NA NA hsa-miR-664a-3p INHBA 0.249882351950296 0.56171157318348 0.597174749350624 0.643310167999085 mirMAP -0.466978716274 0.00658510269681794 NA NA NA hsa-let-7b-3p INHBB 0.589364128513318 0.200507534602851 -1.97271756685436 0.104497007694944 mirMAP -0.463652659221676 0.0021376185872136 NA NA NA hsa-let-7f-1-3p INHBB 1.61507869803314 0.00069342464777815 -1.97271756685436 0.104497007694944 mirMAP -0.404972481178029 0.00541675367886755 NA NA NA hsa-miR-149-5p INHBB 1.18551753240939 0.197439607622379 -1.97271756685436 0.104497007694944 miRNATAP -0.311217107683418 2.76274284748989e-05 NA NA NA hsa-miR-34c-5p INHBB 2.64675661251039 0.0157394735757952 -1.97271756685436 0.104497007694944 miRanda;miRNATAP -0.140882165290134 0.024781810834991 NA NA NA hsa-miR-944 INHBB 7.20925181386398 0.000823207457340648 -1.97271756685436 0.104497007694944 PITA;miRNATAP -0.308259024282992 2.31374161115698e-16 NA NA NA hsa-miR-34c-5p LEFTY1 2.64675661251039 0.0157394735757952 -3.84752015475725 0.0102616402154264 miRanda -0.191448006205679 0.0136317827110864 NA NA NA hsa-miR-338-3p LEFTY2 0.447551118940466 0.558485097370031 -8.66797951018688 5.56505297736723e-07 miRanda -0.335229774792844 0.0105440699603547 NA NA NA hsa-miR-339-5p LEFTY2 1.23326828594484 0.0307501214818698 -8.66797951018688 5.56505297736723e-07 miRanda -0.686073023431591 8.44843734028557e-05 NA NA NA hsa-miR-421 LEFTY2 1.97624148591545 0.000915838012451138 -8.66797951018688 5.56505297736723e-07 miRanda -0.627276884060026 0.000170299323727752 NA NA NA hsa-miR-141-3p LTBP1 7.30474126597325 1.45115996357606e-24 -2.15558708391926 0.00223591567779578 MirTarget -0.123615104125198 0.0175201097951623 NA NA NA hsa-miR-142-5p LTBP1 3.95552531913424 1.49536283724079e-08 -2.15558708391926 0.00223591567779578 PITA -0.182567913642117 0.00113007383986416 NA NA NA hsa-miR-148b-3p LTBP1 1.75622244535669 8.84414356040579e-08 -2.15558708391926 0.00223591567779578 MirTarget -0.375783645725841 0.00215660060435271 NA NA NA hsa-miR-200a-3p LTBP1 6.336081120041 4.024313571871e-16 -2.15558708391926 0.00223591567779578 MirTarget -0.109072348275159 0.0264517346565534 NA NA NA hsa-miR-29b-1-5p LTBP1 0.33698032160171 0.598092174563471 -2.15558708391926 0.00223591567779578 MirTarget -0.150062087396103 0.0181429284860624 NA NA NA hsa-miR-429 LTBP1 6.39965293994036 1.96920201593608e-18 -2.15558708391926 0.00223591567779578 miRanda;miRNATAP -0.104560275036067 0.0444037963112563 NA NA NA hsa-miR-148b-3p MAPK1 1.75622244535669 8.84414356040579e-08 0.0128019530419543 0.96439785606773 mirMAP -0.139901367015828 0.00442278516722453 NA NA NA hsa-miR-29b-2-5p MAPK1 -0.596051745078872 0.189540844841389 0.0128019530419543 0.96439785606773 mirMAP -0.150888486209755 2.15475742904008e-05 NA NA NA hsa-miR-29c-3p MAPK1 -0.414153610337085 0.529344128062017 0.0128019530419543 0.96439785606773 mirMAP -0.121961986993 4.61168241690927e-07 NA NA NA hsa-miR-30b-5p MAPK1 0.0238659735605804 0.953223658270319 0.0128019530419543 0.96439785606773 mirMAP -0.107494044816223 0.00753809874561411 NA NA NA hsa-miR-30e-5p MAPK1 0.780047227271616 0.0346714425913016 0.0128019530419543 0.96439785606773 mirMAP -0.116090988644527 0.00885887810727849 NA NA NA hsa-miR-3913-5p MAPK1 0.145645056779437 0.734844256690741 0.0128019530419543 0.96439785606773 mirMAP -0.108088444698366 0.00439552964093496 NA NA NA hsa-miR-335-5p MYC 0.167216045757305 0.803897055331049 -0.745260197790044 0.453852120838847 miRNAWalker2_validate -0.177349242383061 0.0350467132879494 NA NA NA hsa-miR-34a-5p MYC 0.830377770217786 0.0477544831885907 -0.745260197790044 0.453852120838847 miRNAWalker2_validate;miRTarBase -0.427487830189717 0.00161403194033986 25572695;25686834;21460242;22159222;23640973;22830357;22235332 The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;miR 34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c Myc pathway;Myc mediated repression of microRNA 34a promotes high grade transformation of B cell lymphoma by dysregulation of FoxP1;MicroRNA 34a suppresses malignant transformation by targeting c Myc transcriptional complexes in human renal cell carcinoma; We investigated the functional effects of microRNA-34a miR-34a on c-Myc transcriptional complexes in renal cell carcinoma; miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region which was revealed by luciferase reporter assays; Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription indicating a novel role of miR-34a in the regulation of transcription by c-Myc;Among them miR-34a was also associated with poor prognosis in 2 independent series of leukemic and nodal MCL and in cooperation with high expression of the MYC oncogene;We report that miR-34a did not inhibit cell proliferation notwithstanding a marked down-regulation of c-MYC;MicroRNA 34a modulates c Myc transcriptional complexes to suppress malignancy in human prostate cancer cells; We studied the functional effects of miR-34a on c-Myc transcriptional complexes in PC-3 prostate cancer cells; miR-34a downregulated expression of c-Myc oncogene by targeting its 3' UTR as shown by luciferase reporter assays; This is the first report to document that miR-34a suppresses assembly and function of the c-Myc-Skp2-Miz1 complex that activates RhoA and the c-Myc-pTEFB complex that elongates transcription of various genes suggesting a novel role of miR-34a in the regulation of transcription by c-Myc complex ;;;malignant trasformation;worse prognosis;; bladder cancer;liver cancer;B cell lymphoma;kidney renal cell cancer;lymphoma;lymphoma;prostate cancer hsa-miR-429 MYC 6.39965293994036 1.96920201593608e-18 -0.745260197790044 0.453852120838847 miRNAWalker2_validate -0.351232938868747 9.84375821791447e-07 21684154;24633485 miR 429 modulates the expression of c myc in human gastric carcinoma cells; SGC-7901 gastric cancer cells were transfected with miR-429 mimics and endogenous c-myc expression was detected by western blots; We performed functional assays using the 3'UTR of the c-myc gene as a miR-429 target in a luciferase reporter assay system; miR-429 significantly downregulated endogenous c-myc expression in SGC-7901 cells; Action of miR/429 on c-myc 3'UTR was confirmed; c-myc is an important miR-429 target gene;It is known that miR-429 is down-regulated and functions as a tumor suppressor by targeting c-myc and PLGG1 in gastric and breast cancer ; gastric cancer;sarcoma hsa-miR-101-3p NOG -1.12421603598195 0.0200907284788457 -1.21608867705426 0.353623614382544 miRNATAP -0.588806463252439 0.000125537379245868 NA NA NA hsa-miR-142-5p NOG 3.95552531913424 1.49536283724079e-08 -1.21608867705426 0.353623614382544 miRNATAP -0.522147752334842 3.37362248010374e-07 NA NA NA hsa-miR-200b-3p NOG 5.56167217794639 6.43540045061709e-16 -1.21608867705426 0.353623614382544 MirTarget;TargetScan -0.209041601335479 0.0424697035199917 NA NA NA hsa-miR-362-3p NOG 0.679952485897744 0.226148468488576 -1.21608867705426 0.353623614382544 miRanda;miRNATAP -0.276871154011234 0.0383498324644039 NA NA NA hsa-miR-188-5p PITX2 1.39111178824125 0.0251592818948912 4.53127310697722 0.041781323864126 PITA -0.728008208319922 0.000353396687418111 NA NA NA hsa-miR-217 PITX2 -0.378397407994341 0.717408682071252 4.53127310697722 0.041781323864126 miRanda -0.417759942604483 0.000567867786887708 NA NA NA hsa-miR-30a-3p PITX2 -1.22212086897848 0.167565797592104 4.53127310697722 0.041781323864126 miRNATAP -0.746671574404835 1.01775167632319e-07 NA NA NA hsa-miR-501-5p PITX2 1.0411896821345 0.0777206709183552 4.53127310697722 0.041781323864126 PITA;miRNATAP -0.494912501921518 0.0215121053530382 NA NA NA hsa-miR-425-5p PPP2CB 3.15197291080781 3.16652350906107e-07 -1.25447828974493 1.05312923428955e-05 miRNAWalker2_validate -0.110681790089799 1.64448494638146e-05 NA NA NA hsa-miR-590-3p PPP2CB 2.35429565068338 2.79601879608564e-06 -1.25447828974493 1.05312923428955e-05 miRanda -0.128757858804767 5.16847568396067e-05 NA NA NA hsa-miR-125a-5p PPP2R1B -1.32352790615388 0.00714301627309467 0.535943295428266 0.162251997298493 PITA;miRanda -0.114930033410317 0.00930190483964423 NA NA NA hsa-miR-30e-3p PPP2R1B -0.0362193022195196 0.932577027239525 0.535943295428266 0.162251997298493 mirMAP -0.109171912123649 0.0336857613488188 NA NA NA hsa-miR-452-5p PPP2R1B 2.45466810475361 0.00114794259949532 0.535943295428266 0.162251997298493 MirTarget -0.106017919286185 0.000183245518742969 NA NA NA hsa-miR-590-3p RBL1 2.35429565068338 2.79601879608564e-06 2.78412826041908 1.63046325304296e-06 miRanda;mirMAP -0.146406335107204 0.0267326933843168 NA NA NA hsa-let-7f-2-3p RBL2 1.02768112108475 0.0787293499732611 -0.290362042828854 0.459600981952894 MirTarget -0.110938571443043 0.00433507096732033 NA NA NA hsa-miR-106b-5p RBL2 2.80565545918114 1.14547999022566e-09 -0.290362042828854 0.459600981952894 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.152134757968797 0.00122146155020016 NA NA NA hsa-miR-130a-5p RBL2 1.58028512890005 0.024346333013728 -0.290362042828854 0.459600981952894 MirTarget -0.10715821321623 0.000810244476557906 NA NA NA hsa-miR-32-3p RBL2 2.20477794939766 0.0392771274032852 -0.290362042828854 0.459600981952894 miRNATAP -0.128572933697516 0.000405541163046317 NA NA NA hsa-miR-335-3p RBL2 1.19503568251824 0.0938852560631551 -0.290362042828854 0.459600981952894 MirTarget -0.116365907107437 0.000164887689801712 NA NA NA hsa-miR-335-5p RBL2 0.167216045757305 0.803897055331049 -0.290362042828854 0.459600981952894 miRNAWalker2_validate -0.145019980739739 9.04060047371642e-06 NA NA NA hsa-miR-590-3p RBL2 2.35429565068338 2.79601879608564e-06 -0.290362042828854 0.459600981952894 miRanda -0.194960999183418 6.4906101255289e-06 NA NA NA hsa-miR-664a-3p ROCK1 0.249882351950296 0.56171157318348 -0.508459228982796 0.157162538507041 mirMAP -0.102372137778216 0.0323715103346566 NA NA NA hsa-let-7a-3p ROCK2 0.82512001802525 0.0468122405194487 -0.982794429557542 0.144534846884159 mirMAP -0.287135080994927 0.00198598698276818 NA NA NA hsa-miR-142-3p ROCK2 4.35304505457969 3.10014573651358e-10 -0.982794429557542 0.144534846884159 PITA;miRanda;miRNATAP -0.159877164823284 0.00282210588614417 NA NA NA hsa-miR-142-5p ROCK2 3.95552531913424 1.49536283724079e-08 -0.982794429557542 0.144534846884159 PITA -0.117236282243549 0.028405742008836 NA NA NA hsa-miR-224-3p ROCK2 2.84876340814503 0.000179138399939161 -0.982794429557542 0.144534846884159 mirMAP -0.138248944552857 0.00579163824403207 NA NA NA hsa-miR-3607-3p ROCK2 1.38015131722213 0.0240067155694847 -0.982794429557542 0.144534846884159 mirMAP -0.228150377670738 0.000240782728860781 NA NA NA hsa-miR-590-3p ROCK2 2.35429565068338 2.79601879608564e-06 -0.982794429557542 0.144534846884159 miRanda;mirMAP -0.284800877986152 0.000141234831462107 NA NA NA hsa-miR-107 RPS6KB1 1.49443409571439 0.000130594521065411 0.147277461109991 0.600506468158798 PITA;miRanda -0.111469431880308 0.00608626394063609 NA NA NA hsa-miR-186-5p RPS6KB1 0.445443449112564 0.185447310527704 0.147277461109991 0.600506468158798 MirTarget;miRNATAP -0.188202471127657 8.10651969496359e-05 NA NA NA hsa-miR-125a-5p RPS6KB2 -1.32352790615388 0.00714301627309467 0.879028619054892 0.0118268028070626 miRanda -0.169895564703728 2.13927288529754e-05 NA NA NA hsa-miR-30a-5p SMAD1 -0.768430903969183 0.320487552854215 -0.661773172110887 0.109183209000537 miRNAWalker2_validate;miRTarBase -0.136305243025811 5.1078361443971e-06 NA NA NA hsa-miR-30c-5p SMAD1 0.38723991118075 0.348605235643473 -0.661773172110887 0.109183209000537 miRNAWalker2_validate;miRTarBase -0.118219273416957 0.0397672591212022 NA NA NA hsa-miR-590-5p SMAD1 1.51400888103768 0.0023888567923017 -0.661773172110887 0.109183209000537 miRanda -0.106193842693607 0.0238833385538224 NA NA NA hsa-miR-374b-5p SMAD2 -0.114749866169918 0.764888930049438 0.04613352062659 0.893023563998003 MirTarget -0.129583837300731 0.0115512001155785 NA NA NA hsa-let-7g-3p SMAD3 2.09736290930341 5.30067796437833e-05 0.160014583572917 0.778517282766047 mirMAP -0.257984897034794 2.44423650375142e-05 NA NA NA hsa-miR-17-5p SMAD3 2.3269271449522 2.13987445663942e-05 0.160014583572917 0.778517282766047 miRNAWalker2_validate -0.165009353618131 0.00461261808419179 NA NA NA hsa-miR-186-5p SMAD3 0.445443449112564 0.185447310527704 0.160014583572917 0.778517282766047 mirMAP -0.742764319550064 2.12349457043014e-15 NA NA NA hsa-miR-188-5p SMAD3 1.39111178824125 0.0251592818948912 0.160014583572917 0.778517282766047 PITA -0.238758119317103 3.46346507109757e-06 NA NA NA hsa-miR-20a-3p SMAD3 1.9920766549842 0.000624458530894697 0.160014583572917 0.778517282766047 MirTarget -0.113586093609298 0.0394412989574893 NA NA NA hsa-miR-28-5p SMAD3 -0.815636722979196 0.0221199948901761 0.160014583572917 0.778517282766047 miRNATAP -0.238288702750939 0.00948140473131226 NA NA NA hsa-miR-29b-2-5p SMAD3 -0.596051745078872 0.189540844841389 0.160014583572917 0.778517282766047 mirMAP -0.33018047859631 3.00181288669247e-06 NA NA NA hsa-miR-30a-3p SMAD3 -1.22212086897848 0.167565797592104 0.160014583572917 0.778517282766047 mirMAP -0.125743455849957 0.000500972339732145 NA NA NA hsa-miR-30d-3p SMAD3 -0.0740421896025512 0.857423650167556 0.160014583572917 0.778517282766047 mirMAP -0.265215856067837 0.000784444342632096 NA NA NA hsa-miR-32-3p SMAD3 2.20477794939766 0.0392771274032852 0.160014583572917 0.778517282766047 mirMAP -0.139443193805526 0.00854369021916498 NA NA NA hsa-miR-335-3p SMAD3 1.19503568251824 0.0938852560631551 0.160014583572917 0.778517282766047 mirMAP -0.150203529209219 0.000833797912476475 NA NA NA hsa-miR-335-5p SMAD3 0.167216045757305 0.803897055331049 0.160014583572917 0.778517282766047 miRNAWalker2_validate -0.170051000133026 0.000363968836124472 NA NA NA hsa-miR-345-5p SMAD3 2.77314563304336 4.34343702412489e-05 0.160014583572917 0.778517282766047 mirMAP -0.193422457386819 3.24971867546412e-05 NA NA NA hsa-miR-501-5p SMAD3 1.0411896821345 0.0777206709183552 0.160014583572917 0.778517282766047 mirMAP -0.280514332977103 1.82290826802372e-07 NA NA NA hsa-miR-576-5p SMAD3 1.30320223793746 0.00648929463912994 0.160014583572917 0.778517282766047 mirMAP -0.143556531357487 0.0337207679032995 NA NA NA hsa-miR-589-3p SMAD3 1.33205316880069 0.052632683806148 0.160014583572917 0.778517282766047 mirMAP -0.202014876353946 1.49389042617214e-05 NA NA NA hsa-miR-616-5p SMAD3 2.48416313933027 0.00318247475868827 0.160014583572917 0.778517282766047 mirMAP -0.241397292057418 2.69938790277874e-07 NA NA NA hsa-miR-671-5p SMAD3 1.48527046124636 0.00686722328347111 0.160014583572917 0.778517282766047 MirTarget -0.193412590030654 0.000928749665735432 NA NA NA hsa-miR-7-1-3p SMAD3 1.43074343339835 0.00471215970502094 0.160014583572917 0.778517282766047 mirMAP -0.168365832898427 0.00819700709319524 NA NA NA hsa-miR-769-5p SMAD3 0.41777775802937 0.343089124193569 0.160014583572917 0.778517282766047 miRNATAP -0.366412732630904 4.82674495052425e-07 NA NA NA hsa-miR-21-3p SMAD4 3.50297439576639 6.39946844099206e-10 -1.1222647897474 0.00638923144286853 mirMAP -0.112729088104479 0.00502861854832022 NA NA NA hsa-miR-27a-3p SMAD4 1.76094007417453 0.000216137556256765 -1.1222647897474 0.00638923144286853 MirTarget -0.132335336531126 0.00695151522053189 NA NA NA hsa-miR-32-5p SMAD4 2.93035124381469 5.00149131394151e-10 -1.1222647897474 0.00638923144286853 mirMAP -0.119614186597926 0.0138442807407647 NA NA NA hsa-miR-590-3p SMAD4 2.35429565068338 2.79601879608564e-06 -1.1222647897474 0.00638923144286853 MirTarget;PITA;miRanda;miRNATAP -0.108763251915953 0.0183914722302907 NA NA NA hsa-miR-142-3p SMAD5 4.35304505457969 3.10014573651358e-10 -0.853949329748655 0.0112109152915372 miRanda -0.111458600261676 2.68471648745391e-05 NA NA NA hsa-miR-148b-3p SMAD5 1.75622244535669 8.84414356040579e-08 -0.853949329748655 0.0112109152915372 MirTarget -0.187860765240565 0.00120747050981635 NA NA NA hsa-miR-155-5p SMAD5 2.81443182173772 7.42530504828797e-05 -0.853949329748655 0.0112109152915372 miRNAWalker2_validate;miRTarBase -0.11374059022423 1.54512459183245e-05 20133617 Targeting of SMAD5 links microRNA 155 to the TGF beta pathway and lymphomagenesis; Using unbiased genome-wide approaches in DLBCL we discovered that the oncogenic microRNA-155 miR-155 directly targets the bone morphogenetic protein BMP-responsive transcriptional factor SMAD5; In confirmatory experiments RNAi-based SMAD5 knockdown recapitulated in vitro and in vivo the effects miR-155 overexpression; Furthermore in primary DLBCLs miR-155 overexpression inhibited SMAD5 expression and disrupted its activity as defined by individual and global analyses of its transcriptional targets; Together our data helped explain miR-155 function highlighted a hitherto unappreciated role of SMAD5 in lymphoma biology and defined a unique mechanism used by cancer cells to escape TGF-beta's growth-inhibitory effects lymphoma hsa-miR-374b-5p SMAD5 -0.114749866169918 0.764888930049438 -0.853949329748655 0.0112109152915372 mirMAP -0.113890764454251 0.0245972061559062 NA NA NA hsa-miR-7-1-3p SMAD5 1.43074343339835 0.00471215970502094 -0.853949329748655 0.0112109152915372 MirTarget;mirMAP -0.125172771217674 0.000874421069844358 NA NA NA hsa-miR-330-5p SMAD6 2.25110496739954 0.000275527655397415 -0.725649172744241 0.290132180635957 miRanda -0.184917477614592 0.00299016941550084 NA NA NA hsa-miR-590-3p SMAD6 2.35429565068338 2.79601879608564e-06 -0.725649172744241 0.290132180635957 miRanda -0.267326610379956 0.000457963476050754 NA NA NA hsa-miR-106a-5p SMAD7 3.98693608217557 9.37722470816656e-07 -0.95880969992043 0.0366992059513236 miRNATAP -0.149963254737491 1.31781139734866e-06 NA NA NA hsa-miR-106b-5p SMAD7 2.80565545918114 1.14547999022566e-09 -0.95880969992043 0.0366992059513236 miRNATAP -0.153866006306842 0.00543882440686572 27619676;25286029;22286770 MiR 106b promotes migration and invasion through enhancing EMT via downregulation of Smad 7 in Kazakh's esophageal squamous cell carcinoma; To understand the regulation between miR-106b and Smad 7 qRT-PCR and western blot were performed; Smad 7 was confirmed as a downstream target of miR-106b in our experimental setting; Our results indicated that miR-106b can promote migration and invasion of ESCC cells through enhancing EMT process via downregulation of Smad 7 suggesting that miR-106b can be a potential molecular phenotype in ESCC metastases;Smad7 which inhibits transforming growth factor-β TGF-β/Smad signaling as a target of the miR-106b family was downregulated in CD44+ cells;The miR 106b 25 cluster targets Smad7 activates TGF β signaling and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancer metastasis;; esophageal cancer;gastric cancer;breast cancer hsa-miR-15b-5p SMAD7 3.32329949959268 8.40210501034588e-13 -0.95880969992043 0.0366992059513236 miRNAWalker2_validate;MirTarget;miRNATAP -0.12276933574354 0.0240265474350386 NA NA NA hsa-miR-16-5p SMAD7 2.93575808220754 2.15436817162977e-10 -0.95880969992043 0.0366992059513236 miRNAWalker2_validate;MirTarget;miRNATAP -0.11042422783014 0.0454276198480881 NA NA NA hsa-miR-200b-3p SMAD7 5.56167217794639 6.43540045061709e-16 -0.95880969992043 0.0366992059513236 TargetScan;mirMAP -0.134092196812711 0.00017837402933657 NA NA NA hsa-miR-25-3p SMAD7 1.12623030168869 0.00311079344417173 -0.95880969992043 0.0366992059513236 miRNAWalker2_validate;MirTarget;miRNATAP -0.211174530736138 0.00218469576403061 23435373 MicroRNA 25 functions as a potential tumor suppressor in colon cancer by targeting Smad7; Furthermore bioinformatic predictions and experimental validation were used to identify Smad7 as a direct target of miR-25; Functional reverse experiments indicated that the antitumor effects of miR-25 were probably mediated by its repression of Smad7; These results suggest that miR-25 may function as a tumor suppressor by targeting Smad7 in colon cancer colon cancer hsa-miR-32-5p SMAD7 2.93035124381469 5.00149131394151e-10 -0.95880969992043 0.0366992059513236 MirTarget;miRNATAP -0.150227679757323 0.00543246914204553 NA NA NA hsa-miR-34a-5p SMAD7 0.830377770217786 0.0477544831885907 -0.95880969992043 0.0366992059513236 MirTarget -0.162394705492837 0.00963037319305692 NA NA NA hsa-miR-363-3p SMAD7 4.27232887548977 8.53979362839458e-06 -0.95880969992043 0.0366992059513236 MirTarget;miRNATAP -0.129488951229613 8.8174349390813e-07 NA NA NA hsa-miR-590-3p SMAD7 2.35429565068338 2.79601879608564e-06 -0.95880969992043 0.0366992059513236 miRanda -0.142111999176971 0.00557772133316168 NA NA NA hsa-miR-93-5p SMAD7 2.65964181833033 2.58315947526774e-08 -0.95880969992043 0.0366992059513236 miRNATAP -0.112312147157656 0.0366812627519062 25371073 Mothers against decapentaplegic homolog 7 Smad7 as an essential molecular protein for nuclear accumulation of β-catenin in the canonical Wnt signaling pathway is predicted as a putative target gene of miR-93 by the silico method and demonstrated that it may be suppressed by targeting its 3'UTR; These findings showed that miR-93 suppresses colorectal cancer development via downregulating Wnt/β-catenin at least in part by targeting Smad7 colorectal cancer hsa-miR-96-5p SMAD7 5.62521466029286 1.54938806718028e-10 -0.95880969992043 0.0366992059513236 TargetScan;miRNATAP -0.109077445631336 0.00187568919830877 NA NA NA hsa-let-7a-3p SMAD9 0.82512001802525 0.0468122405194487 -2.7376389652288 0.0192963522776041 mirMAP -0.442472512268732 0.00636653266609344 NA NA NA hsa-let-7f-1-3p SMAD9 1.61507869803314 0.00069342464777815 -2.7376389652288 0.0192963522776041 mirMAP -0.643058456662211 3.71020269166814e-06 NA NA NA hsa-miR-142-5p SMAD9 3.95552531913424 1.49536283724079e-08 -2.7376389652288 0.0192963522776041 mirMAP -0.455702968071563 6.87114862979984e-07 NA NA NA hsa-miR-155-5p SMAD9 2.81443182173772 7.42530504828797e-05 -2.7376389652288 0.0192963522776041 mirMAP -0.494912373572471 5.52020257308744e-08 NA NA NA hsa-miR-2355-5p SMAD9 0.418226038913005 0.502149040287915 -2.7376389652288 0.0192963522776041 MirTarget -0.354388746551621 0.000914872258809983 NA NA NA hsa-miR-27a-3p SMAD9 1.76094007417453 0.000216137556256765 -2.7376389652288 0.0192963522776041 MirTarget;miRNATAP -0.476677374881021 0.000614418699263425 NA NA NA hsa-miR-3065-5p SMAD9 2.14185373842821 0.0609400502269891 -2.7376389652288 0.0192963522776041 mirMAP -0.170622567202665 0.0185889320946337 NA NA NA hsa-miR-320c SMAD9 -0.10618808730545 0.854002814666472 -2.7376389652288 0.0192963522776041 MirTarget;miRanda -0.254690136563853 0.0314608616435477 NA NA NA hsa-miR-330-3p SMAD9 2.49094236945806 0.000129367003214715 -2.7376389652288 0.0192963522776041 mirMAP;miRNATAP -0.307590268767431 0.00246486779468069 NA NA NA hsa-miR-3682-3p SMAD9 1.83244576389151 0.0295200056820549 -2.7376389652288 0.0192963522776041 mirMAP -0.194190812232067 0.0484999440530096 NA NA NA hsa-miR-452-3p SMAD9 2.97956996345436 0.000203580834647624 -2.7376389652288 0.0192963522776041 MirTarget -0.269259115360015 0.00104911081565079 NA NA NA hsa-miR-590-3p SMAD9 2.35429565068338 2.79601879608564e-06 -2.7376389652288 0.0192963522776041 mirMAP -0.466193095735401 0.000359685283692022 NA NA NA hsa-miR-625-3p SMAD9 1.75291360644906 0.000840901646169228 -2.7376389652288 0.0192963522776041 mirMAP -0.295543877919876 0.0197436119264055 NA NA NA hsa-miR-629-3p SMAD9 3.48282157979573 4.9176538695908e-08 -2.7376389652288 0.0192963522776041 MirTarget -0.317166674054093 0.00186461760079121 NA NA NA hsa-miR-944 SMAD9 7.20925181386398 0.000823207457340648 -2.7376389652288 0.0192963522776041 mirMAP -0.140004647532406 0.000216024062053183 NA NA NA hsa-miR-125a-5p SMURF1 -1.32352790615388 0.00714301627309467 0.37231414680435 0.273627297997747 MirTarget;PITA;miRanda -0.164265398621157 2.25749305046991e-05 NA NA NA hsa-miR-505-5p SMURF1 -0.548246528900629 0.331409094367131 0.37231414680435 0.273627297997747 MirTarget -0.130251797014335 0.0001242339477502 NA NA NA hsa-miR-92b-3p SMURF1 1.69303761469782 0.0103484911955574 0.37231414680435 0.273627297997747 miRNATAP -0.115623085220887 5.84662448355788e-05 NA NA NA hsa-miR-181b-5p SP1 1.11397227523501 0.0273417050354018 0.159929753261176 0.539653320387308 mirMAP -0.16244900785389 1.23268296448896e-08 NA NA NA hsa-miR-186-5p SP1 0.445443449112564 0.185447310527704 0.159929753261176 0.539653320387308 miRNAWalker2_validate -0.173654685943994 8.59024450148812e-05 NA NA NA hsa-miR-324-5p SP1 1.31253452379847 0.0116806680545163 0.159929753261176 0.539653320387308 PITA -0.105352867542711 0.000170061785235409 26177288 Downregulation of ETS1 and SP1 mediated the inhibitory function of miR-324-5p on HCC migration and invasion liver cancer hsa-miR-335-5p SP1 0.167216045757305 0.803897055331049 0.159929753261176 0.539653320387308 miRNAWalker2_validate -0.10287381677363 1.73733819355203e-06 23740614;21822301 Luciferase reporter assay and Western blot were to verify Bcl-w and SP1 as potential major target genes of miR-335; These results indicated that upregulation of miR-335 can simultaneously suppress the invasiveness and promote apoptosis of lung cancer cell A549 and H1299 by targeting Bcl-w and SP1;MicroRNA 335 acts as a metastasis suppressor in gastric cancer by targeting Bcl w and specificity protein 1; Taken together our results provide evidence that miR-335 might function as a metastasis suppressor in gastric cancer by targeting SP1 directly and indirectly through the Bcl-w-induced phosphoinositide 3-kinase-Akt-Sp1 pathway ;metastasis lung cancer;gastric cancer hsa-miR-374a-3p SP1 0.465360399099794 0.305267458251279 0.159929753261176 0.539653320387308 mirMAP -0.11312774518121 0.00048897969800879 NA NA NA hsa-miR-99b-5p SP1 -0.796155507439137 0.153001114953768 0.159929753261176 0.539653320387308 miRNAWalker2_validate -0.133488124573425 2.75438359703961e-07 NA NA NA hsa-miR-28-5p TFDP1 -0.815636722979196 0.0221199948901761 1.50707697289792 0.000113581984949159 miRanda -0.157053305977995 0.0136634788866607 NA NA NA hsa-miR-30a-3p TFDP1 -1.22212086897848 0.167565797592104 1.50707697289792 0.000113581984949159 MirTarget;miRNATAP -0.117651521698128 2.15488096931028e-06 NA NA NA hsa-miR-30a-5p TFDP1 -0.768430903969183 0.320487552854215 1.50707697289792 0.000113581984949159 MirTarget;miRNATAP -0.149270840448017 1.41969345460429e-07 NA NA NA hsa-miR-374b-5p TFDP1 -0.114749866169918 0.764888930049438 1.50707697289792 0.000113581984949159 MirTarget -0.124240657647707 0.036127077097449 NA NA NA hsa-miR-491-5p TFDP1 0.569358547192776 0.313310594748302 1.50707697289792 0.000113581984949159 miRanda -0.117208486553406 0.00358853398486073 NA NA NA hsa-miR-141-3p TGFB2 7.30474126597325 1.45115996357606e-24 -1.43663821995393 0.208151431685717 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.215624739416799 0.00999464963415708 NA NA NA hsa-miR-142-3p TGFB2 4.35304505457969 3.10014573651358e-10 -1.43663821995393 0.208151431685717 miRNATAP -0.239982637825598 0.00829657759355293 NA NA NA hsa-miR-148b-3p TGFB2 1.75622244535669 8.84414356040579e-08 -1.43663821995393 0.208151431685717 MirTarget -0.652112155639784 0.000929853930431754 NA NA NA hsa-miR-200a-3p TGFB2 6.336081120041 4.024313571871e-16 -1.43663821995393 0.208151431685717 MirTarget;miRNATAP -0.351128170275698 7.00885632360109e-06 25813153 Tumor suppressive microRNA 200a inhibits renal cell carcinoma development by directly targeting TGFB2; By performing quantitative real-time PCR ELISA and luciferase reporter assays transforming growth factor beta2 TGFB2 was validated as a direct target gene of miR-200a; Moreover siRNA-mediated knockdown of TGFB2 partially phenocopied the effect of miR-200a overexpression; These results suggest that miR-200a suppresses RCC development via directly targeting TGFB2 indicating that miR-200a may present a novel target for diagnostic and therapeutic strategies in RCC kidney renal cell cancer hsa-miR-203a-3p TGFB2 6.35084246337388 7.89944323347948e-08 -1.43663821995393 0.208151431685717 MirTarget -0.267521839692763 3.62940840958117e-07 NA NA NA hsa-miR-2277-5p TGFB2 3.02139935290539 0.0134629626930938 -1.43663821995393 0.208151431685717 MirTarget -0.249573719882911 0.00777879243940924 NA NA NA hsa-miR-362-3p TGFB2 0.679952485897744 0.226148468488576 -1.43663821995393 0.208151431685717 miRanda -0.252409907074068 0.0301240629015872 NA NA NA hsa-miR-362-5p TGFB2 -1.22309034685697 0.0452665543907975 -1.43663821995393 0.208151431685717 MirTarget -0.314690950040788 0.00297612558507577 NA NA NA hsa-miR-375 TGFB2 3.3784490463318 0.0449946294355695 -1.43663821995393 0.208151431685717 miRNAWalker2_validate -0.113027113272895 0.00302877404950613 NA NA NA hsa-miR-429 TGFB2 6.39965293994036 1.96920201593608e-18 -1.43663821995393 0.208151431685717 miRNATAP -0.317868138018968 0.000128726503171991 NA NA NA hsa-miR-454-3p TGFB2 1.40269869979902 0.00366085847011367 -1.43663821995393 0.208151431685717 MirTarget;miRNATAP -0.327134482586007 0.0150919225078625 NA NA NA hsa-miR-500a-5p TGFB2 0.0170829425378565 0.973960207660626 -1.43663821995393 0.208151431685717 mirMAP -0.329451267369997 0.00832586461531593 NA NA NA hsa-miR-500b-5p TGFB2 0.0167434146432646 0.974498641907253 -1.43663821995393 0.208151431685717 MirTarget -0.327405186316064 0.00868447231417683 NA NA NA hsa-miR-616-5p TGFB2 2.48416313933027 0.00318247475868827 -1.43663821995393 0.208151431685717 mirMAP -0.189478149280231 0.0488014870593231 NA NA NA hsa-miR-9-3p TGFB2 1.69328215716742 0.125170982657059 -1.43663821995393 0.208151431685717 MirTarget -0.125746331392832 0.0346375662627605 NA NA NA hsa-let-7f-1-3p TGFB3 1.61507869803314 0.00069342464777815 -2.17732916051247 0.00128816902304754 MirTarget -0.28544584743246 0.000437940636180159 NA NA NA hsa-miR-151a-5p TGFB3 1.0755926560327 0.00684662665520532 -2.17732916051247 0.00128816902304754 MirTarget -0.500615620870658 2.12682352848945e-07 NA NA NA hsa-miR-629-3p TGFB3 3.48282157979573 4.9176538695908e-08 -2.17732916051247 0.00128816902304754 MirTarget -0.241806561248301 3.8838732840276e-05 NA NA NA hsa-let-7b-5p TGFBR1 -0.189422992330471 0.651878220048983 -0.505713612135208 0.324744061078335 miRNATAP -0.242601587479934 0.000517890990887836 27234654 rs868 is contained in a let-7 miRNA binding site in the 3'UTR of TGFBR1 which might provide a functional basis for the association in MSS HNPCC; In luciferase assays the risk-associated allele for rs868 was associated with half the luciferase expression in the presence of miRNA let-7b-5p compared with protective allele suggesting more binding of let-7b-5p and less TGFBR1 expression colorectal cancer hsa-let-7c-5p TGFBR1 -2.03831836681378 0.0228401148731997 -0.505713612135208 0.324744061078335 miRNAWalker2_validate;miRTarBase -0.141642653096274 9.4282969596595e-06 NA NA NA hsa-let-7g-5p TGFBR1 0.857251702023746 0.00647597344297273 -0.505713612135208 0.324744061078335 miRNATAP -0.267873123242374 0.00450205280436413 NA NA NA hsa-miR-101-3p TGFBR1 -1.12421603598195 0.0200907284788457 -0.505713612135208 0.324744061078335 miRNAWalker2_validate;miRNATAP -0.25766117737473 1.65614003073399e-05 NA NA NA hsa-miR-101-5p TGFBR1 -1.41522721523565 0.0166784131265028 -0.505713612135208 0.324744061078335 mirMAP -0.147066901987004 0.00277627040116552 NA NA NA hsa-miR-128-3p TGFBR1 1.36248409467631 0.00408435995818078 -0.505713612135208 0.324744061078335 miRNAWalker2_validate;miRTarBase -0.218506283449698 0.000352839376558225 NA NA NA hsa-miR-130b-3p TGFBR1 3.9204771543282 1.2714917955808e-11 -0.505713612135208 0.324744061078335 miRNATAP -0.119162445421437 0.0143458308514524 NA NA NA hsa-miR-186-5p TGFBR1 0.445443449112564 0.185447310527704 -0.505713612135208 0.324744061078335 mirMAP -0.227217146959954 0.0101798716638516 NA NA NA hsa-miR-200b-3p TGFBR1 5.56167217794639 6.43540045061709e-16 -0.505713612135208 0.324744061078335 mirMAP -0.254716587127543 6.86106889972148e-11 20498632 Inhibition of TGFbeta receptor 1 TGFBR1 in these cells induced MET and reduction of prometastatic miR-21 but caused an increase of the miR-200 family thyroid cancer hsa-miR-3065-5p TGFBR1 2.14185373842821 0.0609400502269891 -0.505713612135208 0.324744061078335 mirMAP -0.111612566907259 0.000387470900601915 NA NA NA hsa-miR-361-5p TGFBR1 0.00649167180664723 0.985202350239079 -0.505713612135208 0.324744061078335 miRanda;mirMAP;miRNATAP -0.236124496506177 0.00538272648027843 NA NA NA hsa-miR-374a-5p TGFBR1 0.278549982012055 0.45888283715888 -0.505713612135208 0.324744061078335 mirMAP -0.235099661936825 0.0027662227971746 NA NA NA hsa-miR-374b-5p TGFBR1 -0.114749866169918 0.764888930049438 -0.505713612135208 0.324744061078335 mirMAP -0.196695985221129 0.0107478368749896 NA NA NA hsa-miR-429 TGFBR1 6.39965293994036 1.96920201593608e-18 -0.505713612135208 0.324744061078335 miRanda;miRNATAP -0.219958031472476 1.89353165194703e-09 NA NA NA hsa-miR-452-5p TGFBR1 2.45466810475361 0.00114794259949532 -0.505713612135208 0.324744061078335 mirMAP -0.12029641667783 0.00160222545222133 NA NA NA hsa-miR-106a-5p TGFBR2 3.98693608217557 9.37722470816656e-07 -2.73335386207413 1.90521047769449e-05 miRTarBase;miRNATAP -0.150075579446973 0.000678032994747311 22912877 MiR-106a inhibits the expression of transforming growth factor-β receptor 2 TGFBR2 leading to increased CRC cell migration and invasion cell migration colorectal cancer hsa-miR-106b-5p TGFBR2 2.80565545918114 1.14547999022566e-09 -2.73335386207413 1.90521047769449e-05 miRNATAP -0.322471465860215 3.16067025691578e-05 NA NA NA hsa-miR-130b-3p TGFBR2 3.9204771543282 1.2714917955808e-11 -2.73335386207413 1.90521047769449e-05 miRNAWalker2_validate;miRNATAP -0.213593769351299 0.000481445052465677 25024357 Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC lung squamous cell cancer hsa-miR-17-5p TGFBR2 2.3269271449522 2.13987445663942e-05 -2.73335386207413 1.90521047769449e-05 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.215187086531778 0.00117456700436254 25011053;27120811 We demonstrate that miR-17 overexpression interferes with the TGFβ-EMT axis and hinders RCC sphere formation; and validated TGFBR2 as a direct and biologically relevant target during this process;MiR-17-5p was found to bind to the 3'UTR of TGFBR2 mRNA and further validation of this specific binding was performed through a reporter assay; An inverse correlation between miR-17-5p and TGFBR2 protein was observed in gastric cancer tissues; Cell studies revealed that miR-17-5p negatively regulated TGFBR2 expression by directly binding to the 3'UTR of TGFBR2 mRNA thereby promoting cell growth and migration; The results of our study suggest a novel regulatory network in gastric cancer mediated by miR-17-5p and TGFBR2 and may indicate that TGFBR2 could serve as a new therapeutic target in gastric cancer ; kidney renal cell cancer;gastric cancer hsa-miR-18a-5p TGFBR2 3.90770175770219 9.15298615034137e-10 -2.73335386207413 1.90521047769449e-05 miRNAWalker2_validate -0.135343234498317 0.0158042568581437 NA NA NA hsa-miR-19a-3p TGFBR2 2.17020503944519 0.00122084653711062 -2.73335386207413 1.90521047769449e-05 miRNAWalker2_validate;miRNATAP -0.114838162156062 0.0351708776182258 NA NA NA hsa-miR-19b-3p TGFBR2 1.67581705793313 0.000858910586302716 -2.73335386207413 1.90521047769449e-05 miRNAWalker2_validate;miRNATAP -0.234916804375819 0.0012466880966742 NA NA NA hsa-miR-20a-5p TGFBR2 2.13553469875764 0.000181201072324354 -2.73335386207413 1.90521047769449e-05 miRNAWalker2_validate;miRTarBase;miRNATAP -0.20359230487236 0.00142468050698815 NA NA NA hsa-miR-23a-3p TGFBR2 0.925125296618358 0.0127293543936914 -2.73335386207413 1.90521047769449e-05 miRNATAP -0.3112107869471 0.00186820770972094 NA NA NA hsa-miR-23b-3p TGFBR2 -0.581135273821923 0.190478897170459 -2.73335386207413 1.90521047769449e-05 miRNATAP -0.396202249615838 1.57688737786639e-06 NA NA NA hsa-miR-33a-3p TGFBR2 2.06269680799532 0.00156436055383943 -2.73335386207413 1.90521047769449e-05 mirMAP -0.339046189283903 6.57537246748805e-10 NA NA NA hsa-miR-340-5p TGFBR2 1.41210478721579 0.00958612942879818 -2.73335386207413 1.90521047769449e-05 mirMAP -0.166384599375896 0.0138225168393814 NA NA NA hsa-miR-429 TGFBR2 6.39965293994036 1.96920201593608e-18 -2.73335386207413 1.90521047769449e-05 miRNATAP -0.154633278802292 0.00105886610005129 NA NA NA hsa-miR-454-3p TGFBR2 1.40269869979902 0.00366085847011367 -2.73335386207413 1.90521047769449e-05 miRNATAP -0.167813642713129 0.0280513088873595 NA NA NA hsa-miR-502-5p TGFBR2 -0.614788359240004 0.318237800399635 -2.73335386207413 1.90521047769449e-05 miRNATAP -0.208965899672639 0.000640450504063216 NA NA NA hsa-miR-590-3p TGFBR2 2.35429565068338 2.79601879608564e-06 -2.73335386207413 1.90521047769449e-05 miRanda -0.257641439028576 0.000348477751441795 NA NA NA hsa-miR-590-5p TGFBR2 1.51400888103768 0.0023888567923017 -2.73335386207413 1.90521047769449e-05 miRNAWalker2_validate;miRTarBase;PITA;miRanda;miRNATAP -0.215019200724794 0.00350246324243056 NA NA NA hsa-miR-9-3p TGFBR2 1.69328215716742 0.125170982657059 -2.73335386207413 1.90521047769449e-05 miRNATAP -0.160602299630754 1.35393247444156e-06 NA NA NA hsa-miR-9-5p TGFBR2 1.79620806707734 0.14526963042518 -2.73335386207413 1.90521047769449e-05 miRNATAP -0.159363587250353 4.39117866793099e-08 25024357 Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC lung squamous cell cancer hsa-miR-92a-3p TGFBR2 1.87892405805529 1.27013821556583e-05 -2.73335386207413 1.90521047769449e-05 miRNAWalker2_validate -0.35871093164404 2.09836401920038e-05 NA NA NA hsa-miR-93-5p TGFBR2 2.65964181833033 2.58315947526774e-08 -2.73335386207413 1.90521047769449e-05 miRNAWalker2_validate;miRNATAP -0.331832507260209 9.43453774065979e-06 NA NA NA hsa-let-7a-5p THBS1 0.148081801547773 0.645305441523746 -3.75129916683394 0.000103499881096753 miRNAWalker2_validate;TargetScan -0.497243904586914 0.00492292853577542 NA NA NA hsa-let-7b-5p THBS1 -0.189422992330471 0.651878220048983 -3.75129916683394 0.000103499881096753 miRNAWalker2_validate -0.295885346124448 0.027277440657787 NA NA NA hsa-let-7d-5p THBS1 0.831142050231414 0.0126955498524287 -3.75129916683394 0.000103499881096753 miRNAWalker2_validate -0.35203665179998 0.0381821983604575 NA NA NA hsa-miR-16-1-3p THBS1 2.83281226969693 7.54359864580834e-09 -3.75129916683394 0.000103499881096753 MirTarget -0.643028399066049 3.09438933664662e-09 NA NA NA hsa-miR-17-5p THBS1 2.3269271449522 2.13987445663942e-05 -3.75129916683394 0.000103499881096753 miRNAWalker2_validate -0.267945077391595 0.00757970547802144 NA NA NA hsa-miR-182-5p THBS1 5.86988712704738 1.22411588571584e-15 -3.75129916683394 0.000103499881096753 MirTarget -0.241099584124763 0.000765040193303936 24053448 Effects of anti miR 182 on TSP 1 expression in human colon cancer cells: there is a sense in antisense?; We investigate on the molecular mechanism by which miR-182 could regulate thrombospondin-1 TSP-1 expression a protein downregulated in CRC and inversely correlated with tumor vascularity and metastasis; miR-182 over-expressed in colorectal cancer CRC has like predictive target thrombospondin-1 TSP-1 a protein inversely correlated with tumor vascularity and metastasis that results downregulated in different types of cancer including CRC; We found that TSP-1 increased after transfection with anti-miR-182 and we showed that miR-182 targets TSP-1 3'UTR-mRNA in both cells; Our data suggest that miR-182 targets the anti-angiogenic factor TSP-1 and that anti-miR-182 determines an upregulation of TSP-1 expression in colon cancer cells metastasis colon cancer hsa-miR-186-5p THBS1 0.445443449112564 0.185447310527704 -3.75129916683394 0.000103499881096753 mirMAP -0.462978112860335 0.00599316633809753 NA NA NA hsa-miR-19a-3p THBS1 2.17020503944519 0.00122084653711062 -3.75129916683394 0.000103499881096753 MirTarget;mirMAP -0.199426716244453 0.0152276681051316 NA NA NA hsa-miR-19b-3p THBS1 1.67581705793313 0.000858910586302716 -3.75129916683394 0.000103499881096753 MirTarget;mirMAP -0.333448340944079 0.00241856130914615 NA NA NA hsa-miR-200a-5p THBS1 6.52092140839401 5.73108242597059e-22 -3.75129916683394 0.000103499881096753 MirTarget -0.485719624657622 5.54901388898712e-11 NA NA NA hsa-miR-200b-5p THBS1 6.81954246537908 6.31100593281326e-24 -3.75129916683394 0.000103499881096753 MirTarget -0.501001329221048 9.13787343375865e-12 NA NA NA hsa-miR-20a-5p THBS1 2.13553469875764 0.000181201072324354 -3.75129916683394 0.000103499881096753 miRNAWalker2_validate -0.307672252327679 0.00140150807491854 NA NA NA hsa-miR-3065-5p THBS1 2.14185373842821 0.0609400502269891 -3.75129916683394 0.000103499881096753 MirTarget -0.227705987060518 0.000143233633612563 NA NA NA hsa-miR-32-5p THBS1 2.93035124381469 5.00149131394151e-10 -3.75129916683394 0.000103499881096753 mirMAP -0.296572650133784 0.0100039646653493 NA NA NA hsa-miR-33a-3p THBS1 2.06269680799532 0.00156436055383943 -3.75129916683394 0.000103499881096753 MirTarget;mirMAP -0.24999380439174 0.00320886077009575 NA NA NA hsa-miR-375 THBS1 3.3784490463318 0.0449946294355695 -3.75129916683394 0.000103499881096753 miRanda -0.104064726462059 0.00140403889155616 NA NA NA hsa-miR-500a-5p THBS1 0.0170829425378565 0.973960207660626 -3.75129916683394 0.000103499881096753 mirMAP -0.360122797705364 0.000716954259923395 NA NA NA hsa-miR-576-5p THBS1 1.30320223793746 0.00648929463912994 -3.75129916683394 0.000103499881096753 mirMAP -0.371752416748424 0.00133090246897115 NA NA NA hsa-miR-590-3p THBS1 2.35429565068338 2.79601879608564e-06 -3.75129916683394 0.000103499881096753 miRanda -0.305195275125083 0.00517237635189344 NA NA NA hsa-miR-616-5p THBS1 2.48416313933027 0.00318247475868827 -3.75129916683394 0.000103499881096753 mirMAP -0.253411231221945 0.00197529844240196 NA NA NA hsa-miR-92a-3p THBS1 1.87892405805529 1.27013821556583e-05 -3.75129916683394 0.000103499881096753 miRNAWalker2_validate -0.313123627363836 0.0148198638493974 NA NA NA hsa-miR-106a-5p THBS2 3.98693608217557 9.37722470816656e-07 -2.62795619060355 0.00635907547670508 MirTarget -0.336063474905193 2.56551669416365e-07 NA NA NA hsa-miR-106b-5p THBS2 2.80565545918114 1.14547999022566e-09 -2.62795619060355 0.00635907547670508 MirTarget -0.754072944240837 2.88430240077148e-11 NA NA NA hsa-miR-142-5p THBS2 3.95552531913424 1.49536283724079e-08 -2.62795619060355 0.00635907547670508 mirMAP -0.208949988681772 0.00645371511907511 NA NA NA hsa-miR-146b-5p THBS2 1.87569569182453 0.000737241069698886 -2.62795619060355 0.00635907547670508 miRanda -0.216014529457816 0.0285101129782403 NA NA NA hsa-miR-16-2-3p THBS2 3.79845098071094 1.49120139344659e-13 -2.62795619060355 0.00635907547670508 mirMAP -0.678064085425023 1.06849736981054e-11 NA NA NA hsa-miR-17-5p THBS2 2.3269271449522 2.13987445663942e-05 -2.62795619060355 0.00635907547670508 MirTarget;TargetScan -0.460832414079987 2.70142073659636e-06 NA NA NA hsa-miR-182-5p THBS2 5.86988712704738 1.22411588571584e-15 -2.62795619060355 0.00635907547670508 MirTarget;miRNATAP -0.185107388497314 0.00936294018881331 NA NA NA hsa-miR-20a-5p THBS2 2.13553469875764 0.000181201072324354 -2.62795619060355 0.00635907547670508 MirTarget -0.415858722079042 1.12986282215266e-05 NA NA NA hsa-miR-20b-5p THBS2 4.5662923200279 4.75238200639144e-05 -2.62795619060355 0.00635907547670508 MirTarget -0.199742215607688 2.8796635402953e-05 NA NA NA hsa-miR-29b-3p THBS2 0.666547117072858 0.234055379278093 -2.62795619060355 0.00635907547670508 MirTarget -0.229102488868415 0.0201260250926879 NA NA NA hsa-miR-32-3p THBS2 2.20477794939766 0.0392771274032852 -2.62795619060355 0.00635907547670508 miRNATAP -0.311183273683396 0.000549233998665121 NA NA NA hsa-miR-335-3p THBS2 1.19503568251824 0.0938852560631551 -2.62795619060355 0.00635907547670508 MirTarget;mirMAP -0.238234138626814 0.00191001264899203 NA NA NA hsa-miR-3614-5p THBS2 4.50236405439456 2.75644515847367e-07 -2.62795619060355 0.00635907547670508 miRNATAP -0.20657913597438 0.000767513919935484 NA NA NA hsa-miR-590-3p THBS2 2.35429565068338 2.79601879608564e-06 -2.62795619060355 0.00635907547670508 miRanda;mirMAP -0.366044680216134 0.000684664156327022 NA NA NA hsa-miR-590-5p THBS2 1.51400888103768 0.0023888567923017 -2.62795619060355 0.00635907547670508 miRanda -0.401872758797421 0.000247068390424525 NA NA NA hsa-miR-93-5p THBS2 2.65964181833033 2.58315947526774e-08 -2.62795619060355 0.00635907547670508 MirTarget -0.540936215734632 1.26073372180003e-06 NA NA NA hsa-miR-96-5p THBS2 5.62521466029286 1.54938806718028e-10 -2.62795619060355 0.00635907547670508 TargetScan;miRNATAP -0.298099877132397 5.09583790054224e-05 NA NA NA hsa-miR-423-5p THBS3 0.227366878624794 0.5653498335202 -1.57702454993947 0.000336933739949757 PITA;miRNATAP -0.133376765620382 0.0391467361119457 NA NA NA hsa-miR-550a-5p THBS3 1.21781238856895 0.0613791144699551 -1.57702454993947 0.000336933739949757 MirTarget -0.103051342949095 0.00766263723128083 NA NA NA hsa-miR-142-3p THBS4 4.35304505457969 3.10014573651358e-10 -4.07728930016853 0.00235648126729039 miRanda -0.355816324499892 0.000893784144159221 NA NA NA hsa-miR-320b THBS4 0.20205459771295 0.727216419960509 -4.07728930016853 0.00235648126729039 miRanda -0.376591407193519 0.0045449911696931 NA NA NA hsa-miR-320c THBS4 -0.10618808730545 0.854002814666472 -4.07728930016853 0.00235648126729039 miRanda -0.378120083552424 0.00534438405126932 NA NA NA hsa-miR-361-5p TNF 0.00649167180664723 0.985202350239079 2.70587865709665 0.00827809785812044 miRanda -0.699393715835311 3.55980064084335e-05 NA NA NA hsa-miR-429 TNF 6.39965293994036 1.96920201593608e-18 2.70587865709665 0.00827809785812044 miRNATAP -0.166672367413636 0.0271661300621378 NA NA NA hsa-miR-654-3p TNF -1.00320329950348 0.243908885746048 2.70587865709665 0.00827809785812044 miRNATAP -0.184952039903252 0.006307888857058 NA NA NA hsa-let-7a-3p ZFYVE16 0.82512001802525 0.0468122405194487 -0.258716574920315 0.365988686389883 MirTarget;mirMAP;miRNATAP -0.170912861749384 1.07335028178481e-05 NA NA NA hsa-let-7f-1-3p ZFYVE16 1.61507869803314 0.00069342464777815 -0.258716574920315 0.365988686389883 MirTarget;mirMAP -0.139117709102028 3.68760710387035e-05 NA NA NA hsa-miR-221-3p ZFYVE16 0.94082283577318 0.174749164179978 -0.258716574920315 0.365988686389883 MirTarget -0.143554177116192 2.2255337462971e-10 NA NA NA hsa-miR-222-3p ZFYVE16 1.54730827524553 0.0223014220569407 -0.258716574920315 0.365988686389883 miRNAWalker2_validate;MirTarget -0.131338724635918 1.64775781925967e-08 NA NA NA hsa-miR-374a-5p ZFYVE16 0.278549982012055 0.45888283715888 -0.258716574920315 0.365988686389883 mirMAP -0.109324767341783 0.0121872642924793 NA NA NA hsa-miR-374b-5p ZFYVE16 -0.114749866169918 0.764888930049438 -0.258716574920315 0.365988686389883 mirMAP -0.186735994055013 9.96799953414659e-06 NA NA NA hsa-miR-590-3p ZFYVE16 2.35429565068338 2.79601879608564e-06 -0.258716574920315 0.365988686389883 miRanda -0.120473023123952 0.000133438569444141 NA NA NA hsa-miR-106a-5p ZFYVE9 3.98693608217557 9.37722470816656e-07 -1.00532799582371 0.0462675236152702 MirTarget;miRNATAP -0.123467025158733 0.000328319720625363 NA NA NA hsa-miR-194-5p ZFYVE9 0.691219038144468 0.523143086635506 -1.00532799582371 0.0462675236152702 MirTarget -0.185031753630134 3.38705999024904e-13 NA NA NA hsa-miR-429 ZFYVE9 6.39965293994036 1.96920201593608e-18 -1.00532799582371 0.0462675236152702 miRNATAP -0.106411673524847 0.00390021553053892 NA NA NA hsa-miR-454-3p ZFYVE9 1.40269869979902 0.00366085847011367 -1.00532799582371 0.0462675236152702 MirTarget;miRNATAP -0.159966899402511 0.00709347333104225 NA NA NA