miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7b-5p AIFM1 0.0582902155815681 0.781400138984745 -0.329550499905558 0.0674559184109906 miRNATAP -0.191354974755116 0.00202142122613475 NA NA NA hsa-let-7i-5p AIFM1 0.798954594465461 2.99735653959449e-05 -0.329550499905558 0.0674559184109906 miRNATAP -0.232193884359356 0.000490983449999865 NA NA NA hsa-miR-125b-5p AIFM1 -0.509303501421334 0.133265526313161 -0.329550499905558 0.0674559184109906 miRNATAP -0.223254137922591 7.72555568716759e-10 NA NA NA hsa-miR-199a-5p AIFM1 0.371973504507027 0.232661597228763 -0.329550499905558 0.0674559184109906 miRanda -0.206809881643961 2.68432595992921e-07 NA NA NA hsa-miR-21-5p AKT2 1.75445050487988 2.41825549682022e-23 -0.0135478038511252 0.922701697200587 miRNAWalker2_validate -0.147206602823392 0.00352458167442573 NA NA NA hsa-miR-29b-3p AKT2 -0.230693226193598 0.367461626035234 -0.0135478038511252 0.922701697200587 MirTarget -0.141689777106604 0.000224365237662475 26512921;26564501;24076586 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3;The expression of miR-29b was significantly upregualted by cisplatin treatmentwhile its target gene AKT2 was downregulated;Furthermore a feed-back loop comprising of c-Myc miR-29 family and Akt2 were found in myeloid leukemogenesis ;; ovarian cancer;gastric cancer;acute myeloid leukemia hsa-miR-106b-5p AKT3 1.70863907461894 2.04074794107142e-08 -0.748577301508132 0.0693608036068007 miRNATAP -0.368902671357459 6.63579377990938e-05 NA NA NA hsa-miR-107 AKT3 0.904627575346218 4.67936495073904e-05 -0.748577301508132 0.0693608036068007 PITA;miRanda -0.596025797372068 4.38261497597827e-06 NA NA NA hsa-miR-15b-5p AKT3 1.62046407540723 5.42152621571078e-09 -0.748577301508132 0.0693608036068007 miRNATAP -0.359857777182961 0.000407223981183838 NA NA NA hsa-miR-16-5p AKT3 1.00515772948091 5.33912942007619e-06 -0.748577301508132 0.0693608036068007 miRNAWalker2_validate;miRTarBase;miRNATAP -0.473860841884761 0.000305952592817196 NA NA NA hsa-miR-17-3p AKT3 1.31126744284937 3.24768335024185e-07 -0.748577301508132 0.0693608036068007 miRNATAP -0.520864813647553 2.25932722443508e-06 NA NA NA hsa-miR-17-5p AKT3 1.65862087862483 8.45603406215941e-08 -0.748577301508132 0.0693608036068007 TargetScan;miRNATAP -0.276276453758938 0.00270096970703173 NA NA NA hsa-miR-29a-3p AKT3 -0.113012156986374 0.615005009685815 -0.748577301508132 0.0693608036068007 miRNATAP -0.408748871699734 0.00212322174807936 NA NA NA hsa-miR-29b-3p AKT3 -0.230693226193598 0.367461626035234 -0.748577301508132 0.0693608036068007 miRNATAP -0.338134432146425 0.00361456599882575 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-32-3p AKT3 0.583525764322974 0.11837203008551 -0.748577301508132 0.0693608036068007 mirMAP -0.324144417685552 0.000230218736536503 NA NA NA hsa-miR-320b AKT3 1.11183660885284 0.000497971211648503 -0.748577301508132 0.0693608036068007 PITA;miRanda;miRNATAP -0.263235906209639 0.00390234919135454 NA NA NA hsa-miR-335-3p AKT3 2.5197689063267 2.20084506976733e-09 -0.748577301508132 0.0693608036068007 mirMAP -0.224460236877792 0.000742588100170571 NA NA NA hsa-miR-33a-3p AKT3 0.347011402017138 0.321709379745392 -0.748577301508132 0.0693608036068007 mirMAP -0.376513667394311 1.68302152281553e-05 NA NA NA hsa-miR-362-3p AKT3 -0.0349414695893027 0.913780708043777 -0.748577301508132 0.0693608036068007 miRanda -0.37545416085904 3.60412362584734e-05 NA NA NA hsa-miR-362-5p AKT3 -0.354508685915981 0.354912078595613 -0.748577301508132 0.0693608036068007 PITA;TargetScan;miRNATAP -0.231850776707854 0.00252522310690117 NA NA NA hsa-miR-501-3p AKT3 0.731876211669996 0.0270421347018303 -0.748577301508132 0.0693608036068007 miRNATAP -0.389710500003727 8.30408434984544e-06 NA NA NA hsa-miR-502-3p AKT3 -0.16442685491191 0.557471818466728 -0.748577301508132 0.0693608036068007 miRNATAP -0.502835122914366 1.28261107693995e-06 NA NA NA hsa-miR-505-3p AKT3 0.82660100642669 0.00111666333288398 -0.748577301508132 0.0693608036068007 mirMAP -0.351999859841566 0.0023495079245673 22051041 We also find that Akt3 correlate inversely with miR-505 modulates drug sensitivity in MCF7-ADR breast cancer hsa-miR-548v AKT3 -0.156004387355895 0.708665170641638 -0.748577301508132 0.0693608036068007 miRNATAP -0.26608196493585 0.000310856014668821 NA NA NA hsa-miR-577 AKT3 0.911619788986754 0.2256062124148 -0.748577301508132 0.0693608036068007 mirMAP -0.230357457399908 2.14832389488646e-09 NA NA NA hsa-miR-616-5p AKT3 0.834052908652744 0.0347835664029363 -0.748577301508132 0.0693608036068007 mirMAP -0.265580906698402 0.000411824587413266 NA NA NA hsa-miR-23a-3p APAF1 1.10685926969665 3.16223452471768e-08 0.298695417693903 0.227685316305025 miRNATAP -0.491899186506395 3.94456341577364e-09 24992592;24249161 Luciferase assay was performed to verify a putative target site of miR-23a in the 3'-UTR of apoptosis protease activating factor 1 APAF1 mRNA; The expression levels of miR-23a and APAF1 in CRC cell lines SW480 and SW620 and clinical samples were assessed using reverse transcription-quantitative real-time PCR RT-qPCR and Western blot; Moreover miR-23a up-regulation was coupled with APAF1 down-regulation in CRC tissue samples;We found that the expression of miR-23a was increased and the level of apoptosis-activating factor-1 APAF-1 was decreased in 5-FU-treated colon cancer cells compared to untreated cells; APAF-1 as a target gene of miR-23a was identified and miR-23a antisense-induced increase in the activation of caspase-9 was observed ; colorectal cancer;colorectal cancer hsa-miR-23b-3p APAF1 -0.286465516491361 0.18664668472995 0.298695417693903 0.227685316305025 miRNATAP -0.541460697050492 5.01748351159025e-12 NA NA NA hsa-miR-27a-3p APAF1 1.29886998470345 2.68986118553486e-08 0.298695417693903 0.227685316305025 miRNATAP -0.390173318022615 4.7184175078605e-08 NA NA NA hsa-miR-27b-3p APAF1 0.0836323965901755 0.725273923274 0.298695417693903 0.227685316305025 miRNATAP -0.477647814500079 2.53647023848586e-11 NA NA NA hsa-miR-708-3p APAF1 0.623782703831307 0.275355868302311 0.298695417693903 0.227685316305025 mirMAP -0.239415264582338 2.50187362969727e-17 NA NA NA hsa-miR-944 APAF1 3.33123095809751 0.0177835044930391 0.298695417693903 0.227685316305025 miRNATAP -0.133026823389135 2.79320179778191e-24 NA NA NA hsa-miR-125a-3p ATM 1.19506542853853 0.00164364545717311 -0.394769053567885 0.0834135681853264 miRanda -0.132495092210333 0.00187961461837904 NA NA NA hsa-miR-203a-3p ATM 1.44736908507496 0.0394116388736904 -0.394769053567885 0.0834135681853264 MirTarget -0.138506783210379 2.82519981053352e-10 24145123;27542403 miR 203 induces oxaliplatin resistance in colorectal cancer cells by negatively regulating ATM kinase; In silico analysis identified ataxia telangiectasia mutated ATM a primary mediator of the DNA damage response as a potential target of miR-203; Using TCGA database we identified a significant reverse correlation of miR-203 and ATM expression in CRC tissues; We validated ATM as a bona fide target of miR-203 in CRC cells; Mutation of the putative miR-203 binding site in the 3' untranslated region 3'UTR of the ATM mRNA abolished the inhibitory effect of miR-203 on ATM;MiR 203 inhibits tumor invasion and metastasis in gastric cancer by ATM; Our results showed that miR-203 was significantly downregulated in gastric cancer tissues and cells while ataxia telangiectasia mutated kinase ATM was upregulated in gastric cancer tissues and cells and was directly regulated by miR-203; ATM knockdown phenocopied the effect of miR-203 overexpression drug resistance;metastasis colorectal cancer;gastric cancer hsa-miR-590-5p ATM 1.04171442093217 0.000272475544954865 -0.394769053567885 0.0834135681853264 mirMAP -0.169733213019369 0.00247037314325533 NA NA NA hsa-miR-30a-5p BAX -1.71922855140016 3.20574349285256e-07 1.23402997413945 2.35105004724979e-11 miRNAWalker2_validate -0.14794228476148 0.000184560208965232 NA NA NA hsa-miR-365a-3p BAX -0.891537000455889 0.0025537650440002 1.23402997413945 2.35105004724979e-11 miRNAWalker2_validate -0.185079422057606 5.80881818302673e-05 24216611 MiR 365 induces gemcitabine resistance in pancreatic cancer cells by targeting the adaptor protein SHC1 and pro apoptotic regulator BAX drug resistance pancreatic cancer hsa-miR-15b-3p BCL2 1.75738933306437 3.00554466232543e-08 -1.09374208002759 0.00317080214601605 mirMAP -0.23817009094778 0.00334370547706688 25594541;26915294;26884837;18449891 MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MiR 15b mediates liver cancer cells proliferation through targeting BCL 2; MiR-15b overexpression downregulated BCL2 mRNA and protein expression obviously P < 0.05; On the contrary miR-15b inhibitor transfection markedly reduced miR-15b expression in liver cancer cells P < 0.05 promoted tumor cell proliferation and increased BCL2 mRNA and protein expression; MiR-15b can inhibit HepG2 cell proliferation and down-regulate BCL2 mRNA and protein expression;miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2 ;poor survival;;drug resistance breast cancer;lung cancer;liver cancer;gastric cancer hsa-miR-16-2-3p BCL2 1.8048179609245 2.83095715136409e-09 -1.09374208002759 0.00317080214601605 mirMAP -0.256921078159685 0.0022954047853729 NA NA NA hsa-miR-200a-5p BCL2 1.50371809098978 0.00263602434344863 -1.09374208002759 0.00317080214601605 mirMAP -0.211128800630803 4.95343554899065e-05 NA NA NA hsa-miR-200b-3p BCL2 0.974577911407732 0.0595020056914543 -1.09374208002759 0.00317080214601605 miRNAWalker2_validate;miRTarBase;TargetScan;mirMAP -0.182246427033851 0.000341103736622929 NA NA NA hsa-miR-200b-5p BCL2 0.969871521250413 0.0530500454130183 -1.09374208002759 0.00317080214601605 mirMAP -0.205249290010733 0.000189759214886854 NA NA NA hsa-miR-200c-3p BCL2 1.28185685499076 0.00369777635539177 -1.09374208002759 0.00317080214601605 miRNAWalker2_validate;miRTarBase;mirMAP -0.226804029845278 0.000126679308092617 NA NA NA hsa-miR-20a-3p BCL2 1.13957127410163 0.000451087640268489 -1.09374208002759 0.00317080214601605 mirMAP -0.220252577355485 0.00668844206923876 NA NA NA hsa-miR-21-5p BCL2 1.75445050487988 2.41825549682022e-23 -1.09374208002759 0.00317080214601605 miRNAWalker2_validate;miRTarBase -0.574405109042944 2.28190201261615e-05 21468550;25994220;25381586;26555418;23359184;22964582;21376256 BCL-2 up-regulation could be achieved by miR-21 overexpression which prevented T24 cells from apoptosis induced by doxorubicin; Furthermore the miR-21 induced BCL-2 up-regulation could be cancelled by the PI3K inhibitor LY294002;Meanwhile miR-21 loss reduced STAT3 and Bcl-2 activation causing an increase in the apoptosis of tumour cells in CAC mice;Changes in the sensitivity of osteosarcoma cells to CDDP were examined after transfection with miR-21 mimics or anti-miR-21 or bcl-2 siRNA in combination with CDDP;The expression of Bax Bcl-2 and miR-21 in parental and paclitaxel-resistant cells was detected by RT-PCR and Western blotting;Resveratrol induces apoptosis of pancreatic cancers cells by inhibiting miR 21 regulation of BCL 2 expression; We also used Western blot to measure BCL-2 protein levels after down-regulation of miR-21 expression; Besides down-regulation of miR-21 expression can inhibit BCL-2 expression in PANC-1 CFPAC-1 and MIA Paca-2 cells; Over-expression of miR-21 expression can reverse down-regulation of BCL-2 expression and apoptosis induced by resveratrol; In this study we demonstrated that the effect of resveratrol on apoptosis is due to inhibiting miR-21 regulation of BCL-2 expression;Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;Bcl 2 upregulation induced by miR 21 via a direct interaction is associated with apoptosis and chemoresistance in MIA PaCa 2 pancreatic cancer cells; However the roles and mechanisms of miRNA miR-21 in regulation of Bcl-2 in pancreatic cancer remain to be elucidated; Then luciferase activity was observed after miR-21 mimics and pRL-TK plasmids containing wild-type and mutant 3'UTRs of Bcl-2 mRNA were co-transfected; Cells transfected with miR-21 inhibitor revealed an opposite trend. There was a significant increase in luciferase activity in the cells transfected with the wild-type pRL-TK plasmid in contrast to those transfected with the mutant one indicating that miR-21 promotes Bcl-2 expression by binding directly to the 3'UTR of Bcl-2 mRNA; Upregulation of Bcl-2 directly induced by miR-21 is associated with apoptosis chemoresistance and proliferation of MIA PaCa-2 pancreatic cancer cells ;;;;;;drug resistance bladder cancer;colorectal cancer;sarcoma;breast cancer;pancreatic cancer;lung cancer;pancreatic cancer hsa-miR-29a-5p BCL2 0.585084040404152 0.023014129158495 -1.09374208002759 0.00317080214601605 mirMAP -0.284870122627372 0.0062184185769466 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29 liver cancer hsa-miR-335-3p BCL2 2.5197689063267 2.20084506976733e-09 -1.09374208002759 0.00317080214601605 mirMAP -0.166369508302009 0.00598265233221658 NA NA NA hsa-miR-429 BCL2 1.40182602301928 0.00900426780286475 -1.09374208002759 0.00317080214601605 miRNAWalker2_validate;miRTarBase;PITA;mirMAP -0.202333078759473 3.04924059291668e-05 23999873;26513239;26511969 MiR 429 up regulation induces apoptosis and suppresses invasion by targeting Bcl 2 and SP 1 in esophageal carcinoma; Subsequent Western blotting and luciferase reporter assays showed that miR-429 can bind to putative binding sites within the Bcl-2 and SP1 mRNA 3' untranslated regions UTRs to reduce their expression; Up-regulation of miR-429 inhibits invasion and promotes apoptosis in EC cells by targeting Bcl-2 and SP1; Our findings suggest that Bcl-2 and SP1 may serve as major targets of miR-429;MiR 429 Induces Gastric Carcinoma Cell Apoptosis Through Bcl 2; Here we studied the levels of miR-429 and anti-apoptotic protein Bcl-2 in GC specimens; We performed bioinformatics analyses and used luciferase-reporter assay to analyze the relationship between miR-429 and Bcl-2 in GC cells; MiR-429 levels were significantly decreased and Bcl-2 levels were significantly increased in GC specimens compared to the paired adjacent non-tumor gastric tissue; Moreover the levels of miR-429 and Bcl-2 inversely correlated in GC specimens; Bioinformatics analyses showed that miR-429 targeted the 3'-UTR of Bcl-2 mRNA to inhibit its translation which was confirmed by luciferase-reporter assay;MiR 429 induces apoptosis of glioblastoma cell through Bcl 2; Here we analyzed the levels of miR-429 and anti-apoptotic protein Bcl-2 in GBM specimens; We combined bioinformatics analyses and luciferase reporter assay to determine the relationship between miR-429 and Bcl-2 in GBM cells; We found that miR-429 levels were significantly decreased and Bcl-2 levels were significantly increased in GBM specimens compared to the paired adjacent non-tumor brain tissue; Moreover the levels of miR-429 and Bcl-2 inversely correlated; MiR-429 targeted the 3'-UTR of Bcl-2 mRNA to inhibit its translation ;; esophageal cancer;gastric cancer;glioblastoma hsa-miR-455-5p BCL2 1.20462751989145 6.74386011867484e-05 -1.09374208002759 0.00317080214601605 mirMAP -0.354129750010572 3.78782094978964e-05 NA NA NA hsa-miR-577 BCL2 0.911619788986754 0.2256062124148 -1.09374208002759 0.00317080214601605 PITA -0.10050287983592 0.00537086108513998 NA NA NA hsa-miR-7-5p BCL2 1.63575693499363 0.0124424214624534 -1.09374208002759 0.00317080214601605 miRNAWalker2_validate;miRTarBase;mirMAP -0.142794989912626 0.000680645769025094 26464649;25862909;21750649 Western blotting was used to evaluate the effect of miR-7 on Bcl2 in A549 and H460 cells; Moreover subsequent experiments showed that BCL-2 was downregulated by miR-7 at both transcriptional and translational levels; This study further extends the biological role of miR-7 in NSCLC A549 and H460 cells and identifies BCL-2 as a novel target possibly involved in miR-7-mediated growth suppression and apoptosis induction of NSCLC cells;miR-7 overexpression correlated with diminished BCL2 expression but there was no relationship between miR-7 and EGFR expression neither in tumour samples nor in the cell lines; Of the two postulated miR-7 target genes we examined BCL2 but not EGFR seems to be a possible miR-7 target in OC;Bioinformatics predictions revealed a potential binding site of miR-7 on 3'UTR of BCL-2 and it was further confirmed by luciferase assay; Moreover subsequent experiments showed that BCL-2 was downregulated by miR-7 at both transcriptional and translational levels; These results suggest that miR-7 regulates the expression of BCL-2 through direct 3'UTR interactions ;; lung squamous cell cancer;ovarian cancer;lung squamous cell cancer hsa-let-7b-5p BCL2L1 0.0582902155815681 0.781400138984745 0.213751739166448 0.395782450784369 miRNATAP -0.314285217081765 0.000268924662830079 26915294;20347499 As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;The let 7 family of microRNAs inhibits Bcl xL expression and potentiates sorafenib induced apoptosis in human hepatocellular carcinoma; The effect of let-7 on Bcl-xL expression was examined by Western blot and a reporter assay; Microarray analysis followed by in silico target prediction identified let-7 microRNAs as being downregulated in Huh7 hepatoma cells in comparison with primary human hepatocytes as well as possessing a putative target site in the bcl-xl mRNA poor survival; lung cancer;liver cancer hsa-let-7c-5p BCL2L1 -0.503482361446512 0.206848395212976 0.213751739166448 0.395782450784369 miRNAWalker2_validate;miRTarBase -0.198493465039984 6.59628301755695e-06 20347499 Over-expression of let-7c or let-7g led to a clear decrease of Bcl-xL expression in Huh7 and HepG2 cell lines; Reporter assays revealed direct post-transcriptional regulation involving let-7c or let-7g and the 3'-untranslated region of bcl-xl mRNA liver cancer hsa-miR-149-5p BCL2L1 0.706277554734069 0.296848731347677 0.213751739166448 0.395782450784369 mirMAP -0.173000301400021 4.12180118165392e-12 NA NA NA hsa-miR-214-3p BCL2L1 1.01201534142544 0.00625092909225755 0.213751739166448 0.395782450784369 mirMAP -0.12678075713813 0.00823737366000966 NA NA NA hsa-miR-23b-3p BCL2L1 -0.286465516491361 0.18664668472995 0.213751739166448 0.395782450784369 miRNAWalker2_validate -0.389042865664013 2.23464331013867e-06 NA NA NA hsa-miR-491-5p CAPN1 -0.693578126269305 0.0313646742330058 0.46710889632859 0.0478649092769723 miRanda -0.184673486668961 0.000496187970468952 NA NA NA hsa-miR-107 CAPN2 0.904627575346218 4.67936495073904e-05 -0.586663057719878 0.00617400395352454 miRanda -0.197768883350134 0.00394907266083995 NA NA NA hsa-miR-320a CAPN2 0.593888711838028 0.011897419390526 -0.586663057719878 0.00617400395352454 miRanda -0.258289986910646 6.42445165326642e-05 NA NA NA hsa-miR-320b CAPN2 1.11183660885284 0.000497971211648503 -0.586663057719878 0.00617400395352454 miRanda -0.164820430492686 0.000480039367141294 NA NA NA hsa-miR-421 CAPN2 1.80720854070385 1.59709651202848e-07 -0.586663057719878 0.00617400395352454 miRanda -0.181112317538687 2.00714893454957e-05 NA NA NA hsa-miR-125b-5p CASP10 -0.509303501421334 0.133265526313161 0.324838353536535 0.449881772912426 mirMAP -0.449087306744439 3.61566839470125e-07 NA NA NA hsa-miR-129-5p CASP10 -2.56914016541176 2.36237896095709e-06 0.324838353536535 0.449881772912426 mirMAP -0.153611209701923 0.00569612745338825 NA NA NA hsa-miR-145-3p CASP10 -1.64531410450617 1.69916538962193e-05 0.324838353536535 0.449881772912426 mirMAP -0.218540289944103 0.00524822997508139 NA NA NA hsa-miR-145-5p CASP10 -1.75133578902314 1.54965572197748e-05 0.324838353536535 0.449881772912426 mirMAP -0.212093598244869 0.00404223124849514 NA NA NA hsa-miR-34c-3p CASP10 2.25273698056457 9.06191072601281e-05 0.324838353536535 0.449881772912426 mirMAP -0.31620449305764 4.34162369825633e-10 NA NA NA hsa-miR-452-5p CASP10 2.08756506185889 0.000258095769002813 0.324838353536535 0.449881772912426 mirMAP -0.282928083510076 2.93087174018704e-08 NA NA NA hsa-miR-744-3p CASP10 1.40439584998788 0.000973603203532439 0.324838353536535 0.449881772912426 mirMAP -0.351511141760014 4.23229368717493e-07 NA NA NA hsa-miR-23b-3p CASP7 -0.286465516491361 0.18664668472995 0.221699714130274 0.301273280139001 MirTarget -0.193386816394858 0.00670740113208553 NA NA NA hsa-miR-9-3p CASP7 0.330346058941473 0.541111939982661 0.221699714130274 0.301273280139001 MirTarget -0.101221266430696 0.000505068364865864 NA NA NA hsa-miR-129-5p CASP8 -2.56914016541176 2.36237896095709e-06 1.08073884606891 5.24067403889636e-07 miRanda -0.14203060790996 3.69274761688692e-07 NA NA NA hsa-miR-143-3p CASP8 -0.661937718854688 0.0483213962135842 1.08073884606891 5.24067403889636e-07 MirTarget -0.193498599025905 3.01762109778414e-05 NA NA NA hsa-miR-193b-3p CASP9 0.281752012268679 0.451258902263119 -0.314756842171161 0.110040278687801 miRNAWalker2_validate -0.173981251979618 2.15802379337291e-06 NA NA NA hsa-miR-130a-3p CFLAR 0.146223920674657 0.633739795905839 0.0720322851418542 0.738188372927117 mirMAP -0.143102232833246 0.0042096005919206 NA NA NA hsa-miR-130b-3p CFLAR 1.32714007211004 4.78676252285191e-05 0.0720322851418542 0.738188372927117 mirMAP -0.210127485723908 3.30780313901517e-06 NA NA NA hsa-miR-15b-5p CFLAR 1.62046407540723 5.42152621571078e-09 0.0720322851418542 0.738188372927117 mirMAP -0.216364599318049 3.69635651871987e-05 NA NA NA hsa-miR-301a-3p CFLAR 1.44721900431161 6.35068481036652e-06 0.0720322851418542 0.738188372927117 mirMAP -0.200905622703673 1.22637297314175e-05 NA NA NA hsa-miR-9-5p CFLAR -0.195328736653048 0.761470692992178 0.0720322851418542 0.738188372927117 mirMAP -0.129368546803925 1.64710267403862e-08 NA NA NA hsa-miR-152-3p CHUK 0.436002345388935 0.161701199884702 -0.111597771177896 0.436110414435051 MirTarget -0.173337618013613 3.78615463498576e-08 NA NA NA hsa-miR-195-5p CHUK -0.907998841926297 0.00150511564650591 -0.111597771177896 0.436110414435051 miRNAWalker2_validate;MirTarget -0.133199766126432 0.000124702259663161 NA NA NA hsa-miR-23a-3p CHUK 1.10685926969665 3.16223452471768e-08 -0.111597771177896 0.436110414435051 MirTarget -0.16996459977061 0.000556739825154491 NA NA NA hsa-miR-23b-3p CHUK -0.286465516491361 0.18664668472995 -0.111597771177896 0.436110414435051 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.186735010864747 6.42002077885917e-05 NA NA NA hsa-miR-342-3p CHUK 0.318119432680668 0.269150960124243 -0.111597771177896 0.436110414435051 miRanda -0.186912661037413 4.74504057766316e-08 NA NA NA hsa-miR-497-5p CHUK -0.801030912431774 0.00360386743876612 -0.111597771177896 0.436110414435051 MirTarget -0.109322835458534 0.00272843002977532 NA NA NA hsa-miR-15b-3p CSF2RB 1.75738933306437 3.00554466232543e-08 -0.200137813184114 0.596568526131504 mirMAP -0.312420406243405 0.000120694089204471 NA NA NA hsa-miR-30b-3p CSF2RB -0.266398938200332 0.400847813143994 -0.200137813184114 0.596568526131504 MirTarget -0.245556903717171 0.003931259065523 NA NA NA hsa-miR-452-3p CSF2RB 2.2028815467959 0.00185370432491004 -0.200137813184114 0.596568526131504 mirMAP -0.133306575465583 0.0015572310697747 NA NA NA hsa-miR-342-3p CYCS 0.318119432680668 0.269150960124243 0.195262771266198 0.359129576262205 mirMAP -0.206285282933732 7.83163671388272e-05 NA NA NA hsa-miR-342-3p DFFA 0.318119432680668 0.269150960124243 0.0120370172509965 0.934238830694791 mirMAP -0.102006639384243 0.00439905570386533 NA NA NA hsa-miR-199a-5p DFFB 0.371973504507027 0.232661597228763 0.212840421957756 0.407842476169045 miRanda -0.20194549347049 0.000557924406397779 NA NA NA hsa-miR-199b-5p DFFB 0.124595928096068 0.678156859366405 0.212840421957756 0.407842476169045 miRanda -0.161280275487813 0.00849920247295308 NA NA NA hsa-miR-365a-3p DFFB -0.891537000455889 0.0025537650440002 0.212840421957756 0.407842476169045 MirTarget -0.41279484896589 1.43247424506894e-12 NA NA NA hsa-miR-130b-3p ENDOD1 1.32714007211004 4.78676252285191e-05 0.173942577209361 0.52051984762621 MirTarget -0.221529929695622 0.0001138681713791 NA NA NA hsa-miR-16-1-3p ENDOD1 1.43227522002564 3.70920454953168e-08 0.173942577209361 0.52051984762621 mirMAP -0.213654091575809 0.00290185056658808 NA NA NA hsa-miR-181b-5p ENDOD1 1.64216500592669 1.89228845300725e-08 0.173942577209361 0.52051984762621 MirTarget -0.173013375351316 0.00661465257144989 NA NA NA hsa-miR-181c-5p ENDOD1 0.336826967681288 0.112932307913601 0.173942577209361 0.52051984762621 MirTarget -0.265174587977321 0.00393087804819997 NA NA NA hsa-miR-181d-5p ENDOD1 0.65192727601808 0.0143398117228333 0.173942577209361 0.52051984762621 MirTarget -0.214053420402313 0.00307279912997386 NA NA NA hsa-miR-19a-3p ENDOD1 1.26669687448473 0.000105972838514412 0.173942577209361 0.52051984762621 mirMAP -0.271910605269385 1.74353363266121e-06 NA NA NA hsa-miR-19b-3p ENDOD1 0.759818275708988 0.00652779573186786 0.173942577209361 0.52051984762621 mirMAP -0.330017482149238 9.60364137393709e-07 NA NA NA hsa-miR-20a-3p ENDOD1 1.13957127410163 0.000451087640268489 0.173942577209361 0.52051984762621 MirTarget -0.237417432714634 4.07430637853666e-05 NA NA NA hsa-miR-26b-3p ENDOD1 -0.0103961389461977 0.965770899625511 0.173942577209361 0.52051984762621 mirMAP -0.389217407061445 7.7901649421167e-07 NA NA NA hsa-miR-301a-3p ENDOD1 1.44721900431161 6.35068481036652e-06 0.173942577209361 0.52051984762621 MirTarget -0.174551469878144 0.00291477854957477 NA NA NA hsa-miR-326 ENDOD1 -0.429748586406214 0.2629894124021 0.173942577209361 0.52051984762621 miRanda -0.179053179666302 0.000372552467984529 NA NA NA hsa-miR-335-3p ENDOD1 2.5197689063267 2.20084506976733e-09 0.173942577209361 0.52051984762621 MirTarget -0.17740021575613 3.89969765893599e-05 NA NA NA hsa-miR-3607-3p ENDOD1 0.522750552658156 0.0842510989344654 0.173942577209361 0.52051984762621 MirTarget;miRNATAP -0.251093379289001 6.74689951520392e-05 NA NA NA hsa-miR-361-5p ENDOD1 0.407725414130987 0.0181260969156347 0.173942577209361 0.52051984762621 MirTarget;miRanda -0.416537686793062 0.00024695083695521 NA NA NA hsa-miR-3613-5p ENDOD1 1.11821523851438 0.000249706750761735 0.173942577209361 0.52051984762621 MirTarget -0.254290031486541 3.59830825075084e-05 NA NA NA hsa-miR-450b-5p ENDOD1 0.46157963033014 0.13273722727895 0.173942577209361 0.52051984762621 MirTarget;mirMAP -0.172393535004454 0.0060845153825999 NA NA NA hsa-miR-454-3p ENDOD1 0.625199142970745 0.0134890997402741 0.173942577209361 0.52051984762621 MirTarget -0.40647578762712 4.22203950311284e-08 NA NA NA hsa-miR-589-3p ENDOD1 1.01962606923682 0.00577853347252709 0.173942577209361 0.52051984762621 mirMAP -0.22624680676427 8.66124289089138e-06 NA NA NA hsa-miR-589-5p ENDOD1 0.702695092403762 0.00395772685954799 0.173942577209361 0.52051984762621 MirTarget -0.317235684709577 4.95639850060221e-05 NA NA NA hsa-miR-590-3p ENDOD1 1.11654983899947 0.000160782154924864 0.173942577209361 0.52051984762621 miRanda -0.270082396760333 2.04706660293418e-05 NA NA NA hsa-miR-149-5p EXOG 0.706277554734069 0.296848731347677 -0.162295093538277 0.334751390384514 MirTarget -0.100190512100333 2.75690635023969e-09 NA NA NA hsa-miR-24-3p EXOG 1.08578167539644 6.18549359075268e-07 -0.162295093538277 0.334751390384514 MirTarget -0.205017755650949 0.000120305772178939 NA NA NA hsa-miR-129-5p FADD -2.56914016541176 2.36237896095709e-06 1.34054312587879 0.000321450092241079 miRanda -0.174823490854185 0.000319064240302471 NA NA NA hsa-miR-7-5p FADD 1.63575693499363 0.0124424214624534 1.34054312587879 0.000321450092241079 miRNAWalker2_validate -0.123581882815797 0.00376774438421864 NA NA NA hsa-miR-106a-5p FAS -0.173255688252641 0.642872703263671 0.657268335933371 0.0207009292820455 miRNAWalker2_validate;miRTarBase -0.15547134509945 0.00429149494899305 22431000;27142596 miR 106a is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS; Bioinformatic analysis combining with validation experiments identified FAS as a direct target of miR-106a; Moreover a significant inverse correlation was found between miR-106a and FAS expression not only in gastric cancer cell lines but also in gastric cancer specimens; Taken together these findings suggest that ectopicly overexpressed miR-106a may play an oncogenic role in gastric carcinogenesis and impair extrinsic apoptotic pathway through targeting FAS;Functional experiment ascertained that miR-106a interacted with FAS and mediated caspase3 pathway tumorigenesis; gastric cancer;gastric cancer hsa-miR-129-5p FAS -2.56914016541176 2.36237896095709e-06 0.657268335933371 0.0207009292820455 miRanda -0.124419506861282 0.000695154070004086 NA NA NA hsa-miR-92b-3p FASLG 1.33518446513417 1.45350885391576e-06 0.493896235569131 0.390001245956277 miRNATAP -0.542744180708012 0.000155394781632395 NA NA NA hsa-miR-125a-3p IKBKB 1.19506542853853 0.00164364545717311 0.134870081917275 0.507473312093685 miRanda -0.128753900358831 0.000649508610645324 NA NA NA hsa-miR-543 IKBKB 0.0323775903217254 0.929458442755522 0.134870081917275 0.507473312093685 miRanda -0.128643682904471 0.00308168626813573 NA NA NA hsa-miR-125a-5p IKBKG -0.878090699011564 0.000213630844319685 0.482871701565075 0.00797160760932323 miRanda -0.235137534713953 1.20912221589607e-05 NA NA NA hsa-miR-148a-3p IKBKG -1.53721533763578 3.55533747293117e-05 0.482871701565075 0.00797160760932323 mirMAP -0.11630876600781 0.000633185783589711 NA NA NA hsa-miR-191-5p IL1A 0.964929997847221 0.000706019788557095 3.98706567663546 1.16849910667626e-05 miRNAWalker2_validate -0.695822638582492 0.00261744460155118 NA NA NA hsa-miR-200a-3p IL1A 0.717826667295984 0.193912116506827 3.98706567663546 1.16849910667626e-05 MirTarget -0.340606001845334 0.00439380383654693 NA NA NA hsa-miR-30a-5p IL1A -1.71922855140016 3.20574349285256e-07 3.98706567663546 1.16849910667626e-05 MirTarget -0.814660149177838 1.64588406524699e-05 NA NA NA hsa-miR-30b-5p IL1A -0.430720743745757 0.0593564057320791 3.98706567663546 1.16849910667626e-05 MirTarget -0.946999569898049 0.00123879394096619 NA NA NA hsa-miR-30c-5p IL1A -0.983130268805942 4.60419218706127e-05 3.98706567663546 1.16849910667626e-05 MirTarget -1.11897157505593 3.38735639049494e-05 NA NA NA hsa-miR-30d-5p IL1A -0.5492586056147 0.0140125082460125 3.98706567663546 1.16849910667626e-05 MirTarget -1.69859525858947 4.69234742994376e-09 NA NA NA hsa-miR-30e-5p IL1A -0.573784818166736 0.0112497802572927 3.98706567663546 1.16849910667626e-05 MirTarget -0.834034959769621 0.0048151786715307 NA NA NA hsa-miR-532-5p IL1A 0.313080805824184 0.252248939356301 3.98706567663546 1.16849910667626e-05 MirTarget -1.08391384408926 6.80635936079074e-06 NA NA NA hsa-miR-664a-3p IL1A -0.83041219170254 0.000136267547251167 3.98706567663546 1.16849910667626e-05 MirTarget -0.897367435115216 0.00322501864839319 NA NA NA hsa-miR-30a-3p IL1B -1.73205137750899 3.2425754511091e-07 1.26826196984759 0.0328751494712569 MirTarget -0.435934837553166 0.000319780723167766 NA NA NA hsa-miR-126-5p IL1R1 0.41765430251855 0.0753161203651532 -0.906995887568108 0.0047158045114454 mirMAP -0.261436359372816 0.00849952221113025 NA NA NA hsa-miR-130b-5p IL1R1 0.701350393759937 0.0510142718395002 -0.906995887568108 0.0047158045114454 mirMAP -0.368233556139774 2.48100078929972e-09 NA NA NA hsa-miR-17-3p IL1R1 1.31126744284937 3.24768335024185e-07 -0.906995887568108 0.0047158045114454 mirMAP -0.693802269428868 9.46806918483647e-18 NA NA NA hsa-miR-186-5p IL1R1 0.149964130725901 0.434709542998771 -0.906995887568108 0.0047158045114454 mirMAP -0.443167338337515 0.000291088595010789 NA NA NA hsa-miR-197-3p IL1R1 0.888854270009261 0.000195183808214449 -0.906995887568108 0.0047158045114454 miRNAWalker2_validate -0.49613040391323 1.22192346297885e-07 NA NA NA hsa-miR-24-3p IL1R1 1.08578167539644 6.18549359075268e-07 -0.906995887568108 0.0047158045114454 miRNATAP -0.424471721385594 3.86777071307179e-05 NA NA NA hsa-miR-26b-5p IL1R1 -0.301646326928219 0.160081421968103 -0.906995887568108 0.0047158045114454 mirMAP -0.459757391461702 1.97133609463222e-05 NA NA NA hsa-miR-30d-3p IL1R1 -0.545113326540761 0.0433733076874155 -0.906995887568108 0.0047158045114454 mirMAP -0.230736331537232 0.00720309202491904 NA NA NA hsa-miR-335-3p IL1R1 2.5197689063267 2.20084506976733e-09 -0.906995887568108 0.0047158045114454 mirMAP -0.316316666355703 3.02394356078111e-10 NA NA NA hsa-miR-361-5p IL1R1 0.407725414130987 0.0181260969156347 -0.906995887568108 0.0047158045114454 miRanda -0.649361583840372 1.38224165077047e-06 NA NA NA hsa-miR-3662 IL1R1 1.82780708047676 0.0054036501346178 -0.906995887568108 0.0047158045114454 mirMAP -0.139395164254141 0.00185011658369509 NA NA NA hsa-miR-590-3p IL1R1 1.11654983899947 0.000160782154924864 -0.906995887568108 0.0047158045114454 miRanda;miRNATAP -0.32389995746728 2.02766398681884e-05 NA NA NA hsa-miR-107 IL1RAP 0.904627575346218 4.67936495073904e-05 1.19905493101495 0.00708677122236795 miRanda -0.72498660799915 2.20472801659065e-07 NA NA NA hsa-miR-139-5p IL1RAP -1.83374360776637 1.22019901002824e-09 1.19905493101495 0.00708677122236795 miRanda -0.272547372839431 0.00746891159879681 NA NA NA hsa-miR-140-5p IL1RAP 0.208193069681326 0.303002433893804 1.19905493101495 0.00708677122236795 miRanda -0.512055041931575 0.00149509182166155 NA NA NA hsa-miR-186-5p IL1RAP 0.149964130725901 0.434709542998771 1.19905493101495 0.00708677122236795 mirMAP -0.537551690584275 0.00161371725040932 NA NA NA hsa-miR-190a-5p IL1RAP -0.735154513525545 0.0662435769685494 1.19905493101495 0.00708677122236795 MirTarget -0.388835397731966 6.50096005244398e-07 NA NA NA hsa-miR-192-5p IL1RAP 0.0809146624034405 0.941057093528709 1.19905493101495 0.00708677122236795 miRNAWalker2_validate -0.26340817515093 1.8269423898969e-24 NA NA NA hsa-miR-215-5p IL1RAP 0.715250240418615 0.573784317311889 1.19905493101495 0.00708677122236795 miRNAWalker2_validate -0.213341497430021 3.63405666713444e-21 NA NA NA hsa-miR-29a-3p IL1RAP -0.113012156986374 0.615005009685815 1.19905493101495 0.00708677122236795 MirTarget;miRNATAP -0.544976271762727 0.000147042224820427 NA NA NA hsa-miR-29b-3p IL1RAP -0.230693226193598 0.367461626035234 1.19905493101495 0.00708677122236795 MirTarget;miRNATAP -0.388175128819188 0.00207019887859382 NA NA NA hsa-miR-29c-3p IL1RAP -1.62454036584589 5.38376515586029e-07 1.19905493101495 0.00708677122236795 MirTarget;miRNATAP -0.389730731662364 4.02368962835987e-05 NA NA NA hsa-miR-335-3p IL1RAP 2.5197689063267 2.20084506976733e-09 1.19905493101495 0.00708677122236795 mirMAP -0.196692209121667 0.00677610742244957 NA NA NA hsa-miR-362-3p IL1RAP -0.0349414695893027 0.913780708043777 1.19905493101495 0.00708677122236795 miRanda -0.316916214451342 0.00145990514687848 NA NA NA hsa-miR-375 IL1RAP -2.94506033785642 0.00570147601654791 1.19905493101495 0.00708677122236795 miRNAWalker2_validate;miRanda -0.230371011043722 3.36076494532311e-17 NA NA NA hsa-miR-577 IL1RAP 0.911619788986754 0.2256062124148 1.19905493101495 0.00708677122236795 mirMAP -0.21893322278354 2.22851674765636e-07 NA NA NA hsa-miR-7-1-3p IL1RAP 0.709309110750947 0.0412301737463194 1.19905493101495 0.00708677122236795 MirTarget -0.420546367243074 3.15641182707541e-06 NA NA NA hsa-miR-95-3p IL1RAP 1.04418546668769 0.0239737000737066 1.19905493101495 0.00708677122236795 MirTarget -0.179669790121027 0.00932523018097376 NA NA NA hsa-miR-3065-5p IRAK2 -0.241623656423063 0.633116553078159 1.3633351101708 0.00182765976046462 mirMAP -0.173330265376889 0.00653878581349746 NA NA NA hsa-miR-34c-5p IRAK2 2.20632574870337 0.000379662996168678 1.3633351101708 0.00182765976046462 miRanda -0.190933511899634 0.000123781852765921 NA NA NA hsa-miR-205-5p IRAK3 3.13520672931882 0.0293226471971167 -1.28292278880275 0.00693377483778813 mirMAP -0.126832150752964 2.76094312601068e-08 NA NA NA hsa-miR-20a-3p IRAK3 1.13957127410163 0.000451087640268489 -1.28292278880275 0.00693377483778813 mirMAP -0.411339623078655 6.35608203513098e-05 NA NA NA hsa-miR-224-3p IRAK3 1.52422171450716 0.00650463542340912 -1.28292278880275 0.00693377483778813 mirMAP -0.287944944449608 9.58373092963594e-06 NA NA NA hsa-miR-3200-3p IRAK3 0.93510295722357 0.0984236007399256 -1.28292278880275 0.00693377483778813 mirMAP -0.214678925912326 0.0012779879321413 NA NA NA hsa-miR-324-5p IRAK3 1.08820215809537 3.11674414561836e-05 -1.28292278880275 0.00693377483778813 miRanda -0.439994098624388 0.000617531696828729 NA NA NA hsa-miR-335-3p IRAK3 2.5197689063267 2.20084506976733e-09 -1.28292278880275 0.00693377483778813 mirMAP -0.267472860372498 0.000518863463965078 NA NA NA hsa-miR-33a-5p IRAK3 0.407757858040717 0.321429014317207 -1.28292278880275 0.00693377483778813 mirMAP -0.373889424975974 4.55782863945046e-06 NA NA NA hsa-miR-361-5p IRAK3 0.407725414130987 0.0181260969156347 -1.28292278880275 0.00693377483778813 miRanda;mirMAP -0.664237197745782 0.00103666478118959 NA NA NA hsa-miR-421 IRAK3 1.80720854070385 1.59709651202848e-07 -1.28292278880275 0.00693377483778813 miRanda;mirMAP -0.257256919163978 0.00737409919690172 NA NA NA hsa-miR-452-3p IRAK3 2.2028815467959 0.00185370432491004 -1.28292278880275 0.00693377483778813 mirMAP -0.287307763504979 3.49213014236789e-08 NA NA NA hsa-miR-708-3p IRAK3 0.623782703831307 0.275355868302311 -1.28292278880275 0.00693377483778813 mirMAP -0.174467830506568 0.00329971006032172 NA NA NA hsa-miR-9-3p IRAK3 0.330346058941473 0.541111939982661 -1.28292278880275 0.00693377483778813 mirMAP -0.236303779612564 0.000292753822407025 NA NA NA hsa-miR-92a-3p IRAK3 1.2209325870225 6.8757197708107e-06 -1.28292278880275 0.00693377483778813 mirMAP -0.544355040380052 7.82819003811389e-06 NA NA NA hsa-miR-944 IRAK3 3.33123095809751 0.0177835044930391 -1.28292278880275 0.00693377483778813 mirMAP -0.159410366044099 8.27508903217135e-09 NA NA NA hsa-miR-16-2-3p IRAK4 1.8048179609245 2.83095715136409e-09 -0.464919789184711 0.00231754450519384 mirMAP -0.109660736850925 0.00139428143173774 NA NA NA hsa-miR-320b IRAK4 1.11183660885284 0.000497971211648503 -0.464919789184711 0.00231754450519384 miRanda -0.111853523804352 0.000853309263704889 NA NA NA hsa-miR-421 IRAK4 1.80720854070385 1.59709651202848e-07 -0.464919789184711 0.00231754450519384 miRanda -0.104423408894593 0.000588902634194444 NA NA NA hsa-miR-17-3p MAP3K14 1.31126744284937 3.24768335024185e-07 -0.259250519497319 0.26795775361 MirTarget -0.190284157688133 0.00260851214537523 NA NA NA hsa-miR-17-5p MAP3K14 1.65862087862483 8.45603406215941e-08 -0.259250519497319 0.26795775361 MirTarget -0.141133091627603 0.00671504081676105 NA NA NA hsa-miR-185-3p MAP3K14 1.33711019171256 3.45756583967985e-05 -0.259250519497319 0.26795775361 MirTarget -0.248869688925321 4.8658984259307e-07 NA NA NA hsa-miR-345-5p MAP3K14 1.83686164833727 1.1036889735857e-08 -0.259250519497319 0.26795775361 MirTarget -0.131943070340609 0.00816023179144145 NA NA NA hsa-miR-429 MAP3K14 1.40182602301928 0.00900426780286475 -0.259250519497319 0.26795775361 miRNATAP -0.101734240054609 0.000846699347081948 NA NA NA hsa-miR-542-3p MAP3K14 0.757649022262991 0.00210575463285599 -0.259250519497319 0.26795775361 miRanda -0.191756297239305 0.00447914443598292 27107696 miR 542 3p suppresses invasion and metastasis by targeting the proto oncogene serine/threonine protein kinase PIM1 in melanoma; The proto-oncogene serine/threonine protein kinase PIM1 was identified as a direct target of miR-542-3p using luciferase reporter assay qRT-PCR and western blot analyses metastasis melanoma hsa-miR-29b-2-5p MYD88 -1.7015307882027 2.84239251703401e-10 0.54749642729313 0.0107730270296967 MirTarget -0.142082363879052 0.00927935909323925 NA NA NA hsa-miR-365a-3p MYD88 -0.891537000455889 0.0025537650440002 0.54749642729313 0.0107730270296967 MirTarget -0.197752525582106 0.000111325434456547 NA NA NA hsa-miR-3065-5p NFKBIA -0.241623656423063 0.633116553078159 0.315554814210481 0.271073728411717 MirTarget -0.112423562227453 0.00640620267431026 NA NA NA hsa-let-7f-5p NGF 0.634633924115866 0.0344982923411787 -0.0044354260251589 0.994557609636983 MirTarget -0.455658818520987 0.00313618077968416 NA NA NA hsa-let-7g-5p NGF 0.325297685027927 0.241142963826631 -0.0044354260251589 0.994557609636983 MirTarget -0.833551967281976 3.8902528304102e-07 NA NA NA hsa-miR-423-5p NGF 0.832613878736338 0.000791321227103338 -0.0044354260251589 0.994557609636983 MirTarget;miRNATAP -0.706016056377721 0.0001322029752225 NA NA NA hsa-miR-429 NGF 1.40182602301928 0.00900426780286475 -0.0044354260251589 0.994557609636983 miRanda -0.396695496445767 2.17739891550587e-06 NA NA NA hsa-miR-126-5p PIK3CA 0.41765430251855 0.0753161203651532 0.181162005416898 0.379919524282219 mirMAP -0.230165325454576 0.000229328041159233 NA NA NA hsa-miR-146a-5p PIK3CA 1.82051649415508 2.03651725047679e-05 0.181162005416898 0.379919524282219 mirMAP -0.130514283326015 8.03472410512393e-05 NA NA NA hsa-miR-148a-5p PIK3CA -0.69329616490858 0.0793012233740369 0.181162005416898 0.379919524282219 mirMAP -0.160710142606256 9.74691916818117e-06 NA NA NA hsa-miR-148b-3p PIK3CA 0.295175884456199 0.17466422420702 0.181162005416898 0.379919524282219 miRNAWalker2_validate -0.270665697414514 6.25461929338548e-05 NA NA NA hsa-miR-186-5p PIK3CA 0.149964130725901 0.434709542998771 0.181162005416898 0.379919524282219 mirMAP -0.283664174467296 0.000254482000083255 NA NA NA hsa-miR-29b-1-5p PIK3CA 0.606560155953522 0.116355599574769 0.181162005416898 0.379919524282219 mirMAP -0.105962073023743 0.00514891759991948 NA NA NA hsa-miR-320b PIK3CA 1.11183660885284 0.000497971211648503 0.181162005416898 0.379919524282219 miRanda -0.131928082159166 0.00355606170878243 NA NA NA hsa-miR-335-5p PIK3CA 1.59953351087307 5.56170899867314e-05 0.181162005416898 0.379919524282219 miRNAWalker2_validate -0.142668444274705 6.55217134166698e-05 NA NA NA hsa-miR-338-5p PIK3CA -1.19659203838734 0.0100316010080496 0.181162005416898 0.379919524282219 mirMAP -0.128160056012068 3.12181075963217e-05 NA NA NA hsa-miR-501-5p PIK3CA 0.266919328110625 0.454779001968586 0.181162005416898 0.379919524282219 mirMAP -0.184484665922465 4.78508048904086e-06 NA NA NA hsa-miR-7-1-3p PIK3CA 0.709309110750947 0.0412301737463194 0.181162005416898 0.379919524282219 mirMAP -0.18347710340594 9.07765701687707e-06 NA NA NA hsa-miR-130a-3p PIK3CB 0.146223920674657 0.633739795905839 0.248944033508746 0.180378115579181 miRNATAP -0.141347568269357 0.0010035949231668 NA NA NA hsa-miR-1468-5p PIK3CD -1.88350218312373 3.31332405201189e-05 0.391814669139483 0.253077445924908 MirTarget -0.217696918010317 3.06934786857079e-05 NA NA NA hsa-miR-30b-3p PIK3CD -0.266398938200332 0.400847813143994 0.391814669139483 0.253077445924908 MirTarget -0.431008741394064 8.57729594514163e-09 NA NA NA hsa-miR-30b-5p PIK3CD -0.430720743745757 0.0593564057320791 0.391814669139483 0.253077445924908 MirTarget -0.481822586915696 5.93876910377637e-06 NA NA NA hsa-miR-30d-5p PIK3CD -0.5492586056147 0.0140125082460125 0.391814669139483 0.253077445924908 MirTarget;miRNATAP -0.669349357920634 2.53796175626459e-10 NA NA NA hsa-miR-616-5p PIK3CD 0.834052908652744 0.0347835664029363 0.391814669139483 0.253077445924908 MirTarget -0.171408745877689 0.0062816347712319 NA NA NA hsa-miR-7-5p PIK3CD 1.63575693499363 0.0124424214624534 0.391814669139483 0.253077445924908 miRTarBase;MirTarget;miRNATAP -0.205801781586893 4.40558507915807e-08 22234835 We first screened and identified a novel miR-7 target phosphoinositide 3-kinase catalytic subunit delta PIK3CD; A correlation between miR-7 and PIK3CD expression was also confirmed in clinical samples of HCC; By targeting PIK3CD mTOR and p70S6K miR-7 efficiently regulates the PI3K/Akt pathway liver cancer hsa-miR-103a-3p PIK3R1 0.840525139266028 5.83536475789158e-07 -1.09428616452248 2.46783518047221e-05 MirTarget;miRNATAP -0.323457232113071 0.0039447769693221 NA NA NA hsa-miR-106b-5p PIK3R1 1.70863907461894 2.04074794107142e-08 -1.09428616452248 2.46783518047221e-05 MirTarget;miRNATAP -0.253346436583178 1.72729352701852e-05 NA NA NA hsa-miR-107 PIK3R1 0.904627575346218 4.67936495073904e-05 -1.09428616452248 2.46783518047221e-05 MirTarget;PITA;miRanda;miRNATAP -0.238654922729134 0.0046938788179217 NA NA NA hsa-miR-128-3p PIK3R1 0.98280381420517 5.77641850797209e-05 -1.09428616452248 2.46783518047221e-05 MirTarget -0.253825409257793 0.000861541031670611 25962360 miR 128 3p suppresses hepatocellular carcinoma proliferation by regulating PIK3R1 and is correlated with the prognosis of HCC patients; Mechanistically miR-128-3p was confirmed to regulate PIK3R1 p85α expression thereby suppressing phosphatidylinositol 3-kinase PI3K/AKT pathway activation using qRT-PCR and western blot analysis; Hence we conclude that miR-128-3p which is frequently downregulated in HCC inhibits HCC progression by regulating PIK3R1 and PI3K/AKT activation and is a prognostic marker for HCC patients worse prognosis;progression liver cancer hsa-miR-144-3p PIK3R1 -0.13309578176575 0.798245647923351 -1.09428616452248 2.46783518047221e-05 mirMAP -0.138673461850839 0.000126186382128809 NA NA NA hsa-miR-15b-5p PIK3R1 1.62046407540723 5.42152621571078e-09 -1.09428616452248 2.46783518047221e-05 MirTarget -0.323211150072369 4.46298725379362e-07 NA NA NA hsa-miR-16-2-3p PIK3R1 1.8048179609245 2.83095715136409e-09 -1.09428616452248 2.46783518047221e-05 MirTarget -0.270383492169966 3.99207467881518e-06 NA NA NA hsa-miR-16-5p PIK3R1 1.00515772948091 5.33912942007619e-06 -1.09428616452248 2.46783518047221e-05 MirTarget -0.405416526556489 9.69480909855754e-07 NA NA NA hsa-miR-17-5p PIK3R1 1.65862087862483 8.45603406215941e-08 -1.09428616452248 2.46783518047221e-05 MirTarget;TargetScan;miRNATAP -0.192199170444737 0.00107429271534319 NA NA NA hsa-miR-182-5p PIK3R1 0.887369486030646 0.0310640781418789 -1.09428616452248 2.46783518047221e-05 miRNATAP -0.160218491940506 0.000398426335382569 NA NA NA hsa-miR-185-5p PIK3R1 1.14351510556643 1.07346945085714e-08 -1.09428616452248 2.46783518047221e-05 miRNATAP -0.41775889137189 4.21636400438791e-06 NA NA NA hsa-miR-188-5p PIK3R1 1.35426907033843 0.00038346077691455 -1.09428616452248 2.46783518047221e-05 MirTarget -0.162900447887926 0.000775923703794411 NA NA NA hsa-miR-200b-3p PIK3R1 0.974577911407732 0.0595020056914543 -1.09428616452248 2.46783518047221e-05 mirMAP -0.103803538669649 0.00409847558383849 NA NA NA hsa-miR-200c-3p PIK3R1 1.28185685499076 0.00369777635539177 -1.09428616452248 2.46783518047221e-05 mirMAP -0.143316221972735 0.00063899158230993 NA NA NA hsa-miR-20a-5p PIK3R1 1.4503375861709 5.7813456424762e-07 -1.09428616452248 2.46783518047221e-05 MirTarget;miRNATAP -0.175478538743826 0.0056099063555159 NA NA NA hsa-miR-21-5p PIK3R1 1.75445050487988 2.41825549682022e-23 -1.09428616452248 2.46783518047221e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.306402457018565 0.00154965993784699 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-212-3p PIK3R1 0.960352937108106 0.00133449812322732 -1.09428616452248 2.46783518047221e-05 MirTarget -0.22956448368642 0.000224776230276284 NA NA NA hsa-miR-22-5p PIK3R1 0.804348748654247 0.000804065112767412 -1.09428616452248 2.46783518047221e-05 mirMAP -0.271562984507077 0.000499671844853285 NA NA NA hsa-miR-221-3p PIK3R1 1.33496247538338 3.82022531235275e-07 -1.09428616452248 2.46783518047221e-05 MirTarget -0.313499877783358 5.35467630228685e-06 NA NA NA hsa-miR-222-3p PIK3R1 1.39382731585819 9.98182478024671e-07 -1.09428616452248 2.46783518047221e-05 MirTarget -0.284754511073413 7.61572703183408e-06 NA NA NA hsa-miR-3065-5p PIK3R1 -0.241623656423063 0.633116553078159 -1.09428616452248 2.46783518047221e-05 MirTarget;mirMAP;miRNATAP -0.124182539774803 0.00105993614946939 NA NA NA hsa-miR-32-3p PIK3R1 0.583525764322974 0.11837203008551 -1.09428616452248 2.46783518047221e-05 mirMAP -0.17265888879632 0.00228085828010069 NA NA NA hsa-miR-320b PIK3R1 1.11183660885284 0.000497971211648503 -1.09428616452248 2.46783518047221e-05 miRNATAP -0.162259703959997 0.00544641812773208 NA NA NA hsa-miR-324-3p PIK3R1 1.04940352369965 0.000387716796520961 -1.09428616452248 2.46783518047221e-05 MirTarget;PITA;miRNATAP -0.184232658949902 0.00347746569584922 NA NA NA hsa-miR-330-3p PIK3R1 0.798460296022179 0.00746538156533435 -1.09428616452248 2.46783518047221e-05 MirTarget;PITA;miRNATAP -0.26440540068663 2.08637052595379e-05 NA NA NA hsa-miR-335-3p PIK3R1 2.5197689063267 2.20084506976733e-09 -1.09428616452248 2.46783518047221e-05 mirMAP -0.148076206465714 0.000495756694433814 NA NA NA hsa-miR-424-5p PIK3R1 1.08509868581983 0.000420473853818268 -1.09428616452248 2.46783518047221e-05 MirTarget -0.287369315123124 1.32105570633977e-06 NA NA NA hsa-miR-429 PIK3R1 1.40182602301928 0.00900426780286475 -1.09428616452248 2.46783518047221e-05 mirMAP;miRNATAP -0.126994249956039 0.00022771493817442 NA NA NA hsa-miR-455-3p PIK3R1 2.29532323519288 1.85675588946527e-07 -1.09428616452248 2.46783518047221e-05 MirTarget;PITA;miRNATAP -0.181586331748295 8.05157474846207e-06 NA NA NA hsa-miR-542-3p PIK3R1 0.757649022262991 0.00210575463285599 -1.09428616452248 2.46783518047221e-05 MirTarget;PITA;miRanda -0.239065351988831 0.0017318237826115 NA NA NA hsa-miR-584-5p PIK3R1 1.68234626630933 0.000166828539264215 -1.09428616452248 2.46783518047221e-05 mirMAP -0.129450210806705 0.00170622715972499 NA NA NA hsa-miR-590-3p PIK3R1 1.11654983899947 0.000160782154924864 -1.09428616452248 2.46783518047221e-05 miRanda;mirMAP -0.266046553887174 1.8351581859886e-05 NA NA NA hsa-miR-590-5p PIK3R1 1.04171442093217 0.000272475544954865 -1.09428616452248 2.46783518047221e-05 MirTarget;PITA;miRanda;miRNATAP -0.297910761408884 3.33366270664506e-06 NA NA NA hsa-miR-629-3p PIK3R1 1.40326397107309 9.7803063526732e-05 -1.09428616452248 2.46783518047221e-05 MirTarget -0.16619442916244 0.00118253063445621 NA NA NA hsa-miR-96-5p PIK3R1 1.14243043653372 0.00942969392739105 -1.09428616452248 2.46783518047221e-05 TargetScan;miRNATAP -0.193630203103858 1.00718533638407e-05 NA NA NA hsa-miR-30a-5p PIK3R2 -1.71922855140016 3.20574349285256e-07 0.00922907299312037 0.961081205853821 miRNATAP -0.137164224996737 0.000346855164996688 NA NA NA hsa-miR-1271-5p PIK3R3 1.15538250415776 0.00207865862606828 -0.662491536689023 0.0210304127874503 mirMAP -0.197799197361284 0.00028487328401707 NA NA NA hsa-miR-185-3p PIK3R3 1.33711019171256 3.45756583967985e-05 -0.662491536689023 0.0210304127874503 MirTarget -0.200301326896551 0.00130353125166929 NA NA NA hsa-miR-511-5p PIK3R3 0.542335183701817 0.127507740178883 -0.662491536689023 0.0210304127874503 MirTarget -0.231823970894027 4.82261601939889e-05 25608840 MiR 511 inhibits growth and metastasis of human hepatocellular carcinoma cells by targeting PIK3R3; We further demonstrated that miR-511 suppressed HCC cell proliferation migration and invasion by repressing PIK3R3 expression metastasis liver cancer hsa-miR-708-3p PIK3R3 0.623782703831307 0.275355868302311 -0.662491536689023 0.0210304127874503 mirMAP -0.147502347303041 2.93933869168246e-05 NA NA NA hsa-miR-182-5p PIK3R5 0.887369486030646 0.0310640781418789 -0.106061319644644 0.802628610118832 MirTarget -0.363007599134275 3.56264538888151e-07 NA NA NA hsa-miR-18a-3p PIK3R5 2.35188582849667 1.39401350286321e-08 -0.106061319644644 0.802628610118832 MirTarget -0.215221108190999 0.00210782353217643 NA NA NA hsa-miR-106b-5p PPP3CA 1.70863907461894 2.04074794107142e-08 -0.311261735064956 0.0874904847441977 miRNATAP -0.177382254092271 1.11662949783484e-05 NA NA NA hsa-miR-142-5p PPP3CA 1.55592486377018 6.69269968016779e-06 -0.311261735064956 0.0874904847441977 PITA;mirMAP;miRNATAP -0.110997481793963 0.00234330425678312 NA NA NA hsa-miR-340-5p PPP3CA -0.164941927483643 0.529910509321278 -0.311261735064956 0.0874904847441977 mirMAP -0.181573032833897 0.000232248398119678 NA NA NA hsa-miR-361-5p PPP3CA 0.407725414130987 0.0181260969156347 -0.311261735064956 0.0874904847441977 miRanda -0.225189217128007 0.0033708826866865 NA NA NA hsa-miR-374b-3p PPP3CA 0.999491658196932 0.00126937019814872 -0.311261735064956 0.0874904847441977 MirTarget -0.164661177292416 0.000153667800685453 NA NA NA hsa-miR-590-5p PPP3CA 1.04171442093217 0.000272475544954865 -0.311261735064956 0.0874904847441977 PITA;miRanda;miRNATAP -0.120747875637189 0.00696948367873323 NA NA NA hsa-miR-940 PPP3CA 1.64406174271686 0.000690854900107004 -0.311261735064956 0.0874904847441977 miRNATAP -0.111531019863646 0.000298626343209584 NA NA NA hsa-miR-107 PPP3CB 0.904627575346218 4.67936495073904e-05 -0.544004942139345 9.04819078192179e-05 miRanda -0.142015238506317 0.00140035242278882 NA NA NA hsa-miR-15a-5p PPP3CB 1.03783090449383 7.40334108980898e-07 -0.544004942139345 9.04819078192179e-05 miRNATAP -0.163057694878539 0.000473345260508312 NA NA NA hsa-miR-15b-5p PPP3CB 1.62046407540723 5.42152621571078e-09 -0.544004942139345 9.04819078192179e-05 miRNATAP -0.186954475055184 2.5872809097186e-08 NA NA NA hsa-miR-16-5p PPP3CB 1.00515772948091 5.33912942007619e-06 -0.544004942139345 9.04819078192179e-05 miRNATAP -0.20524854257795 2.83538301027824e-06 NA NA NA hsa-miR-20a-3p PPP3CB 1.13957127410163 0.000451087640268489 -0.544004942139345 9.04819078192179e-05 miRNATAP -0.125773580763174 2.60598588386373e-05 NA NA NA hsa-miR-339-5p PPP3CB 0.770566566962108 0.00816529093411862 -0.544004942139345 9.04819078192179e-05 miRanda -0.140550747992229 3.00402583828723e-05 NA NA NA hsa-miR-7-1-3p PPP3CB 0.709309110750947 0.0412301737463194 -0.544004942139345 9.04819078192179e-05 mirMAP -0.112769612670814 6.65442420729316e-05 NA NA NA hsa-miR-101-3p PPP3R1 -0.451263906815861 0.0283387250173031 0.365031614184003 0.00208633293716482 miRNATAP -0.129816071813413 0.00164042594155264 NA NA NA hsa-miR-26a-5p PPP3R1 -0.384110714440647 0.0442498636014044 0.365031614184003 0.00208633293716482 MirTarget;miRNATAP -0.142127049894375 0.00146987441972325 NA NA NA hsa-miR-625-5p PRKACA 0.537211086526376 0.203801009380384 -0.0978746557285595 0.44498806360937 MirTarget -0.131652673177358 1.09755795457608e-10 NA NA NA hsa-let-7f-1-3p PRKACB 1.28704406797397 1.17954701106157e-06 -2.00320334289066 3.9598668244402e-09 MirTarget;mirMAP -0.314793266126612 0.000724594726922014 NA NA NA hsa-miR-141-3p PRKACB 1.45548825076434 0.00115958850961764 -2.00320334289066 3.9598668244402e-09 MirTarget;TargetScan;miRNATAP -0.197564834301336 0.000353082319368401 NA NA NA hsa-miR-146b-5p PRKACB 1.547491371264 6.06614361290688e-08 -2.00320334289066 3.9598668244402e-09 miRanda -0.225282836158709 0.00882894958009726 NA NA NA hsa-miR-16-2-3p PRKACB 1.8048179609245 2.83095715136409e-09 -2.00320334289066 3.9598668244402e-09 mirMAP -0.306924849458949 0.000109522279734088 NA NA NA hsa-miR-17-5p PRKACB 1.65862087862483 8.45603406215941e-08 -2.00320334289066 3.9598668244402e-09 TargetScan -0.352359251315541 6.11316064096321e-06 NA NA NA hsa-miR-183-5p PRKACB 1.65900927871187 0.000522025364980187 -2.00320334289066 3.9598668244402e-09 MirTarget -0.181167666603194 0.000458522643446536 NA NA NA hsa-miR-18a-5p PRKACB 2.20211504140984 1.78678887916334e-09 -2.00320334289066 3.9598668244402e-09 miRNATAP -0.316335887919593 1.04839236101925e-06 NA NA NA hsa-miR-200c-3p PRKACB 1.28185685499076 0.00369777635539177 -2.00320334289066 3.9598668244402e-09 MirTarget;miRNATAP -0.207576946884606 0.000221208096678535 NA NA NA hsa-miR-2110 PRKACB 0.759864042760204 0.0723961390557655 -2.00320334289066 3.9598668244402e-09 MirTarget -0.183383468055812 0.00233810067736044 NA NA NA hsa-miR-330-3p PRKACB 0.798460296022179 0.00746538156533435 -2.00320334289066 3.9598668244402e-09 MirTarget -0.302274508758057 0.000317953568855911 NA NA NA hsa-miR-361-5p PRKACB 0.407725414130987 0.0181260969156347 -2.00320334289066 3.9598668244402e-09 miRanda -0.504068079086418 0.000769646776305189 NA NA NA hsa-miR-421 PRKACB 1.80720854070385 1.59709651202848e-07 -2.00320334289066 3.9598668244402e-09 PITA;miRanda -0.335137675315492 1.50625671113954e-06 NA NA NA hsa-miR-590-5p PRKACB 1.04171442093217 0.000272475544954865 -2.00320334289066 3.9598668244402e-09 miRanda -0.271769978727668 0.00186178178431082 NA NA NA hsa-miR-93-5p PRKACB 1.7515174434778 1.59386482413883e-08 -2.00320334289066 3.9598668244402e-09 miRNAWalker2_validate -0.293844505175028 0.000169582064126035 NA NA NA hsa-miR-96-5p PRKACB 1.14243043653372 0.00942969392739105 -2.00320334289066 3.9598668244402e-09 miRNATAP -0.170553493993393 0.00429769927359632 NA NA NA hsa-miR-107 PRKAR1A 0.904627575346218 4.67936495073904e-05 -0.261184869472083 0.054030676709783 miRanda -0.207698852168786 7.16194344210351e-07 NA NA NA hsa-miR-16-5p PRKAR1A 1.00515772948091 5.33912942007619e-06 -0.261184869472083 0.054030676709783 miRNAWalker2_validate -0.115179013016791 0.00723464540139017 NA NA NA hsa-miR-186-5p PRKAR1A 0.149964130725901 0.434709542998771 -0.261184869472083 0.054030676709783 mirMAP -0.194228181056638 0.000123242397936607 NA NA NA hsa-miR-590-3p PRKAR1A 1.11654983899947 0.000160782154924864 -0.261184869472083 0.054030676709783 miRanda;mirMAP -0.101445127776819 0.00143270696911459 NA NA NA hsa-miR-590-5p PRKAR1A 1.04171442093217 0.000272475544954865 -0.261184869472083 0.054030676709783 miRanda -0.130718971976049 6.49091634277093e-05 NA NA NA hsa-let-7a-3p PRKAR2A 0.503048155002889 0.0411145454335299 -0.666395730088886 0.00288924292930231 mirMAP -0.171437002730096 0.00904277111739313 NA NA NA hsa-miR-146b-5p PRKAR2A 1.547491371264 6.06614361290688e-08 -0.666395730088886 0.00288924292930231 miRanda -0.240483022224169 7.29411765911574e-06 NA NA NA hsa-miR-155-5p PRKAR2A 1.28707757465885 8.6344688246758e-05 -0.666395730088886 0.00288924292930231 miRNAWalker2_validate -0.134008640508635 0.00539507207316991 NA NA NA hsa-miR-16-5p PRKAR2A 1.00515772948091 5.33912942007619e-06 -0.666395730088886 0.00288924292930231 miRNAWalker2_validate -0.207678908855717 0.003857231053268 NA NA NA hsa-miR-193b-5p PRKAR2A 0.609581100028941 0.13923921336815 -0.666395730088886 0.00288924292930231 mirMAP -0.163479364217959 1.94623324174598e-05 NA NA NA hsa-miR-21-5p PRKAR2A 1.75445050487988 2.41825549682022e-23 -0.666395730088886 0.00288924292930231 mirMAP -0.368520996816281 5.78384748671194e-06 NA NA NA hsa-miR-342-5p PRKAR2A 0.692955062695486 0.030998736359949 -0.666395730088886 0.00288924292930231 miRNATAP -0.279955905439209 6.45816341333199e-09 NA NA NA hsa-miR-3607-3p PRKAR2A 0.522750552658156 0.0842510989344654 -0.666395730088886 0.00288924292930231 mirMAP -0.185766423696095 0.000431146684646817 NA NA NA hsa-miR-3913-5p PRKAR2A 0.878857760706319 0.00310224428304055 -0.666395730088886 0.00288924292930231 mirMAP -0.157706887180414 0.00346452240723279 NA NA NA hsa-miR-708-3p PRKAR2A 0.623782703831307 0.275355868302311 -0.666395730088886 0.00288924292930231 mirMAP -0.152767847410853 1.65731543794426e-08 NA NA NA hsa-let-7a-3p PRKAR2B 0.503048155002889 0.0411145454335299 -2.31198613740557 1.61040825618149e-06 mirMAP -0.471808257381173 0.00105229078353615 NA NA NA hsa-let-7b-3p PRKAR2B 0.21838629112113 0.296038413622566 -2.31198613740557 1.61040825618149e-06 mirMAP -0.75084135025624 9.81880505110698e-06 NA NA NA hsa-let-7f-1-3p PRKAR2B 1.28704406797397 1.17954701106157e-06 -2.31198613740557 1.61040825618149e-06 mirMAP -0.764528974742934 1.29333946371905e-09 NA NA NA hsa-miR-107 PRKAR2B 0.904627575346218 4.67936495073904e-05 -2.31198613740557 1.61040825618149e-06 miRanda -0.758118622628174 1.0243663351818e-06 NA NA NA hsa-miR-200b-3p PRKAR2B 0.974577911407732 0.0595020056914543 -2.31198613740557 1.61040825618149e-06 TargetScan -0.341423530167314 2.56289480842019e-07 NA NA NA hsa-miR-200c-3p PRKAR2B 1.28185685499076 0.00369777635539177 -2.31198613740557 1.61040825618149e-06 miRNATAP -0.465335692985934 1.01730200009054e-09 NA NA NA hsa-miR-3065-5p PRKAR2B -0.241623656423063 0.633116553078159 -2.31198613740557 1.61040825618149e-06 miRNATAP -0.208480402728595 0.0034742658894993 NA NA NA hsa-miR-335-3p PRKAR2B 2.5197689063267 2.20084506976733e-09 -2.31198613740557 1.61040825618149e-06 mirMAP -0.380221012249217 1.31488396083242e-06 NA NA NA hsa-miR-429 PRKAR2B 1.40182602301928 0.00900426780286475 -2.31198613740557 1.61040825618149e-06 PITA;miRanda;miRNATAP -0.369375352905238 4.36044370799977e-09 NA NA NA hsa-miR-590-3p PRKAR2B 1.11654983899947 0.000160782154924864 -2.31198613740557 1.61040825618149e-06 miRNAWalker2_validate;miRanda -0.536291339909839 3.80317491329214e-06 NA NA NA hsa-miR-92a-3p PRKAR2B 1.2209325870225 6.8757197708107e-06 -2.31198613740557 1.61040825618149e-06 miRNATAP -0.779891965016439 2.15980932687562e-10 NA NA NA hsa-miR-92b-3p PRKAR2B 1.33518446513417 1.45350885391576e-06 -2.31198613740557 1.61040825618149e-06 miRNATAP -0.447001178066512 0.000312365822832101 NA NA NA hsa-miR-29b-3p PRKX -0.230693226193598 0.367461626035234 0.935407411100726 0.00677599594067682 mirMAP -0.295729445077546 0.00247925909788979 NA NA NA hsa-miR-29c-3p PRKX -1.62454036584589 5.38376515586029e-07 0.935407411100726 0.00677599594067682 mirMAP -0.21153018883656 0.00447069863244723 NA NA NA hsa-miR-375 PRKX -2.94506033785642 0.00570147601654791 0.935407411100726 0.00677599594067682 miRNAWalker2_validate;miRanda -0.117495305006097 1.46576878210263e-07 NA NA NA hsa-miR-101-5p RELA -0.567139223563276 0.0306291767849722 0.140295374000207 0.30305268869391 mirMAP -0.114893897809984 0.00171325410868005 NA NA NA hsa-miR-30e-5p RELA -0.573784818166736 0.0112497802572927 0.140295374000207 0.30305268869391 miRNAWalker2_validate -0.152968732905743 0.000301446483160409 NA NA NA hsa-miR-129-5p TNFRSF10A -2.56914016541176 2.36237896095709e-06 1.1281325350254 7.06622121173794e-05 miRanda -0.152320428719599 3.6346498987375e-05 NA NA NA hsa-miR-145-5p TNFRSF10A -1.75133578902314 1.54965572197748e-05 1.1281325350254 7.06622121173794e-05 MirTarget -0.149945853805366 0.00246019679293889 NA NA NA hsa-miR-129-5p TNFSF10 -2.56914016541176 2.36237896095709e-06 2.04795111795554 4.27678125264408e-07 miRanda -0.159446744636556 0.0031250454523856 NA NA NA hsa-miR-139-5p TNFSF10 -1.83374360776637 1.22019901002824e-09 2.04795111795554 4.27678125264408e-07 miRanda -0.265030965603103 0.00515179692371939 NA NA NA hsa-miR-362-3p TNFSF10 -0.0349414695893027 0.913780708043777 2.04795111795554 4.27678125264408e-07 miRanda -0.297111694649573 0.00134455834390954 NA NA NA hsa-miR-320a TRADD 0.593888711838028 0.011897419390526 0.142849160995165 0.455488050060669 miRanda -0.17984037721139 0.00179026006697006 NA NA NA hsa-miR-101-3p XIAP -0.451263906815861 0.0283387250173031 0.188695357914383 0.26752656530042 miRNAWalker2_validate -0.164231452524637 0.00565130321818158 NA NA NA hsa-miR-23a-3p XIAP 1.10685926969665 3.16223452471768e-08 0.188695357914383 0.26752656530042 MirTarget;miRNATAP -0.166198298730543 0.00490865346531272 26439986 Moreover miR-23a expression correlated inversely with the expression of target gene X-linked inhibitor of apoptosis protein XIAP but positively with the caspase-3/7 activity liver cancer hsa-miR-23b-3p XIAP -0.286465516491361 0.18664668472995 0.188695357914383 0.26752656530042 MirTarget;miRNATAP -0.150748366360872 0.0075327317682592 NA NA NA hsa-miR-27a-3p XIAP 1.29886998470345 2.68986118553486e-08 0.188695357914383 0.26752656530042 miRNATAP -0.148384475407046 0.00308776419703669 26662313 miR 27a regulates the sensitivity of breast cancer cells to cisplatin treatment via BAK SMAC/DIABLO XIAP axis; After further investigation we indicated that the knockdown of miR-27a promoted the apoptosis via mitochondrial pathway in T-47D cells treated with CDDP depending on the BAK-second mitochondria-derived activator of caspase/direct IAP binding protein with low pI SMAC/DIABLO-X-linked inhibitor of apoptosis XIAP axis breast cancer hsa-miR-27b-3p XIAP 0.0836323965901755 0.725273923274 0.188695357914383 0.26752656530042 miRNATAP -0.174677599302474 0.000614822065631208 NA NA NA hsa-miR-340-5p XIAP -0.164941927483643 0.529910509321278 0.188695357914383 0.26752656530042 mirMAP;miRNATAP -0.153023334325064 0.000895304263874043 NA NA NA hsa-miR-766-3p XIAP 0.362693027508444 0.224058260234353 0.188695357914383 0.26752656530042 mirMAP -0.124700847404795 0.00203195232365125 NA NA NA