miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-200c-3p ABL2 3.50132673580082 2.42716349086937e-15 -0.318835189302919 0.0455399452105181 MirTarget -0.151868587711699 2.33456607871419e-21 NA NA NA hsa-miR-200c-3p ACTC1 3.50132673580082 2.42716349086937e-15 -7.18598491180022 4.5953181070502e-12 MirTarget -1.33961147875603 5.78382641132517e-39 NA NA NA hsa-miR-200c-3p ADAMTS3 3.50132673580082 2.42716349086937e-15 -1.18158075880111 0.00447810281876853 miRNATAP -0.412864046827974 4.8774551323927e-23 NA NA NA hsa-miR-200c-3p ADCY2 3.50132673580082 2.42716349086937e-15 -3.86571368883929 3.85227988382588e-11 MirTarget;miRNATAP -0.439764377269818 9.87649048383691e-13 NA NA NA hsa-miR-200c-3p AFF3 3.50132673580082 2.42716349086937e-15 -5.00307584182747 3.17401839817713e-23 MirTarget;miRNATAP -0.594392924880098 8.99521592502589e-30 NA NA NA hsa-miR-101-3p AKT3 0.522819989585461 0.00375627731618038 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.334857831597034 0.000597756240419548 NA NA NA hsa-miR-106a-5p AKT3 2.48882002962836 1.99757727374521e-12 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.236478824223264 6.56988295029948e-07 NA NA NA hsa-miR-106b-5p AKT3 2.46782146831112 1.36171495805632e-23 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.521755012930227 1.0756262414999e-15 NA NA NA hsa-miR-107 AKT3 1.30977326593435 1.30372468603965e-11 -1.94162990884529 4.54380296394505e-08 PITA;miRanda -0.438321009170574 6.41595199298462e-07 NA NA NA hsa-miR-15a-5p AKT3 2.34669284378787 1.69544424500258e-23 -1.94162990884529 4.54380296394505e-08 miRNAWalker2_validate;miRTarBase;miRNATAP -0.653282073492048 2.38693369892811e-22 NA NA NA hsa-miR-15b-5p AKT3 1.57112623124278 9.14247846750597e-13 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.4862313443712 1.80429141906685e-10 NA NA NA hsa-miR-16-5p AKT3 1.75824877145857 1.68592440033108e-16 -1.94162990884529 4.54380296394505e-08 miRNAWalker2_validate;miRTarBase;miRNATAP -0.527819854451446 1.06852141480407e-11 NA NA NA hsa-miR-17-3p AKT3 2.2704817679209 1.1667437320211e-22 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.393678889428456 2.72155279297878e-08 NA NA NA hsa-miR-17-5p AKT3 3.2710598467455 9.93128340539455e-27 -1.94162990884529 4.54380296394505e-08 TargetScan;miRNATAP -0.385876321416217 1.42856705542315e-13 NA NA NA hsa-miR-181a-5p AKT3 2.29556023480783 1.8138457900616e-21 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.283343247743329 3.77571043690309e-05 NA NA NA hsa-miR-181b-5p AKT3 2.49307679431293 3.92829250217627e-20 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.273550202394616 7.65012329836386e-06 NA NA NA hsa-miR-181c-5p AKT3 1.58587920618301 1.57506918816933e-10 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.234902996176996 0.000670085449584041 NA NA NA hsa-miR-20a-5p AKT3 3.15577933619191 4.19753346442454e-25 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.397380097014522 3.56434655429537e-14 NA NA NA hsa-miR-20b-5p AKT3 2.07706563022469 1.10107236083433e-05 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.159136097484426 1.15057100055016e-05 NA NA NA hsa-miR-22-3p AKT3 1.21545661147757 1.61670170137775e-13 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.356198759053997 0.000637369773108939 NA NA NA hsa-miR-29b-2-5p AKT3 0.910668640983475 0.00666655585493488 -1.94162990884529 4.54380296394505e-08 mirMAP -0.413342005890553 1.74596670459023e-16 NA NA NA hsa-miR-29b-3p AKT3 1.65828197923813 1.02676780888141e-09 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.328715384299769 1.41956551647306e-07 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-29c-3p AKT3 -0.00968972577705429 0.97099586346872 -1.94162990884529 4.54380296394505e-08 miRNAWalker2_validate;miRNATAP -0.256484648428124 9.16722320814547e-05 NA NA NA hsa-miR-3065-5p AKT3 2.74629919868982 1.86846589298284e-08 -1.94162990884529 4.54380296394505e-08 mirMAP -0.196776388311872 4.09483787014971e-06 NA NA NA hsa-miR-32-3p AKT3 2.02436999565685 5.94091197945307e-09 -1.94162990884529 4.54380296394505e-08 mirMAP -0.274043726011417 8.75730973684685e-07 NA NA NA hsa-miR-320a AKT3 0.438165828017084 0.0390159073347133 -1.94162990884529 4.54380296394505e-08 PITA;miRanda;miRNATAP -0.539139659729602 3.01448987258332e-11 NA NA NA hsa-miR-320b AKT3 1.55692969039548 1.41071034251915e-08 -1.94162990884529 4.54380296394505e-08 PITA;miRanda;miRNATAP -0.376164976249955 1.04134326075959e-09 NA NA NA hsa-miR-335-3p AKT3 3.08791651139852 5.31309869723517e-12 -1.94162990884529 4.54380296394505e-08 mirMAP -0.222130607012057 2.63416728864213e-09 NA NA NA hsa-miR-33a-3p AKT3 1.72765312072219 1.51784443453521e-07 -1.94162990884529 4.54380296394505e-08 mirMAP -0.325733544419159 9.28241682908522e-09 NA NA NA hsa-miR-362-3p AKT3 2.0756816987665 3.89026064579331e-12 -1.94162990884529 4.54380296394505e-08 miRanda -0.16536843343699 0.0049777492806053 NA NA NA hsa-miR-362-5p AKT3 1.59303749908759 9.582675908797e-08 -1.94162990884529 4.54380296394505e-08 PITA;TargetScan;miRNATAP -0.201169258976553 0.000472996311050305 NA NA NA hsa-miR-374a-5p AKT3 0.484615721953736 0.0042981729815149 -1.94162990884529 4.54380296394505e-08 mirMAP -0.289501808595266 0.00547104114009117 NA NA NA hsa-miR-421 AKT3 1.17791565395543 6.78526676976629e-06 -1.94162990884529 4.54380296394505e-08 miRanda;mirMAP -0.270003673244585 4.40560995362011e-05 NA NA NA hsa-miR-501-3p AKT3 1.83132758513743 1.10971547702065e-10 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.357094776714992 1.69773165528929e-09 NA NA NA hsa-miR-502-3p AKT3 1.50560877085049 1.2647489756373e-11 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.326505295822604 2.04961437337709e-05 NA NA NA hsa-miR-505-3p AKT3 1.45322244209148 8.86597629645867e-10 -1.94162990884529 4.54380296394505e-08 mirMAP -0.409352554521824 1.03207996907079e-08 22051041 We also find that Akt3 correlate inversely with miR-505 modulates drug sensitivity in MCF7-ADR breast cancer hsa-miR-769-5p AKT3 1.82023760596845 9.6815886564134e-14 -1.94162990884529 4.54380296394505e-08 PITA;miRNATAP -0.445071301297515 6.71512496875401e-11 NA NA NA hsa-miR-93-5p AKT3 3.03961860136032 1.11672209617395e-24 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.494281511913237 1.38435165024812e-20 NA NA NA hsa-miR-200c-3p AMOTL2 3.50132673580082 2.42716349086937e-15 -1.01147657574476 0.000152881926388237 MirTarget;miRNATAP -0.221900222592948 5.9023125330058e-16 NA NA NA hsa-miR-200c-3p ANKH 3.50132673580082 2.42716349086937e-15 -0.383033248037803 0.21653677802021 miRNATAP -0.293704999353824 4.38875978160917e-21 NA NA NA hsa-miR-200c-3p AP1S2 3.50132673580082 2.42716349086937e-15 -1.3126608153732 9.8644272412276e-09 MirTarget;miRNATAP -0.377382973437296 3.78470396738381e-76 NA NA NA hsa-miR-200c-3p ARHGAP20 3.50132673580082 2.42716349086937e-15 -3.51958526332557 1.95510990509183e-16 MirTarget;miRNATAP -0.506742392754481 2.98862963888212e-31 NA NA NA hsa-miR-200c-3p ARHGAP28 3.50132673580082 2.42716349086937e-15 -1.53718262476907 0.000527104725118492 MirTarget -0.204349679908854 1.23254912467264e-05 NA NA NA hsa-miR-200c-3p ARHGAP6 3.50132673580082 2.42716349086937e-15 -3.24747805818142 5.3316262029649e-12 MirTarget -0.119631574014 0.0192045055385265 NA NA NA hsa-miR-200c-3p ARHGEF17 3.50132673580082 2.42716349086937e-15 -1.19273341470048 1.04178493154994e-08 miRNATAP -0.235823385660431 1.17810613529354e-29 NA NA NA hsa-miR-200c-3p ARL10 3.50132673580082 2.42716349086937e-15 -1.12227531152641 0.00197533796722557 mirMAP -0.287585642120829 1.2253094566474e-14 NA NA NA hsa-miR-200c-3p ASAP1 3.50132673580082 2.42716349086937e-15 0.0593314983478699 0.779444757742406 MirTarget;miRNATAP -0.163513046625557 4.35908270922895e-14 NA NA NA hsa-miR-200c-3p ATXN1 3.50132673580082 2.42716349086937e-15 -1.5104377454496 2.95939614593378e-08 MirTarget;miRNATAP -0.244443711486558 3.1156591845051e-18 NA NA NA hsa-miR-200c-3p BACH2 3.50132673580082 2.42716349086937e-15 -1.52271748612635 0.00133867288726185 mirMAP -0.543118577995022 3.61874329395113e-31 NA NA NA hsa-miR-200c-3p BASP1 3.50132673580082 2.42716349086937e-15 -0.115765471779633 0.797246530625034 miRNATAP -0.189407017412651 6.11095304259437e-05 NA NA NA hsa-miR-200c-3p BCL2 3.50132673580082 2.42716349086937e-15 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase;mirMAP -0.190113918290914 1.87463163361428e-10 NA NA NA hsa-miR-200c-3p BEND4 3.50132673580082 2.42716349086937e-15 -1.96898871811517 7.28857253483474e-05 mirMAP -0.318293614323673 8.49110039241365e-10 NA NA NA hsa-miR-200c-3p BNC2 3.50132673580082 2.42716349086937e-15 -2.95176911794991 3.46014802400024e-09 MirTarget -0.700058514263773 1.38610836642505e-48 NA NA NA hsa-miR-146b-5p BRAF 1.75587235896724 1.15724631266659e-07 -0.0380624164019494 0.839544086141468 miRanda -0.146633871679738 3.64395605099119e-08 21874046;26883911;20406109;21537871 Additionally the activation of thyroid most common oncogenes RET/PTC3 and BRAF in PCCL3 cells upregulated miR-146b-5p expression;miR-146b-5p positively regulates migration and invasion of thyroid normal and tumor follicular cells independently from their original mutation either BRAF or RET/PTC through a mechanism that involves the actin cytoskeleton but not an increased capacity of matrix degradation;The miR-146b expression levels in PTCs with BRAF mutation were significantly higher than those without this mutation p < 0.0001;Among BRAF-positive tumors overexpression of miR-146b was associated with aggressive behavior suggesting that it may further refine the prognostic importance of BRAF ;;; thyroid cancer;thyroid cancer;thyroid cancer;thyroid cancer hsa-miR-199a-5p BRAF 0.592984035153911 0.0674836634175293 -0.0380624164019494 0.839544086141468 miRanda -0.100551330747605 0.000311009640639109 NA NA NA hsa-miR-200c-3p C11orf87 3.50132673580082 2.42716349086937e-15 -1.54750698600423 0.0118571289052622 miRNATAP -0.339559370670116 1.28086252300675e-07 NA NA NA hsa-miR-200c-3p C17orf51 3.50132673580082 2.42716349086937e-15 -0.678914258700408 0.0225411911064938 mirMAP -0.276482032662449 3.7103405322735e-20 NA NA NA hsa-miR-103a-3p CAB39 1.44083190496858 1.53799939616416e-13 -0.477158523544161 0.00138539746274052 MirTarget;miRNATAP -0.172743294933037 1.59792620328537e-06 NA NA NA hsa-miR-151a-3p CAB39 1.24018761527407 1.08839919675408e-07 -0.477158523544161 0.00138539746274052 MirTarget -0.108706219270977 0.000381713653378672 NA NA NA hsa-miR-320a CAB39 0.438165828017084 0.0390159073347133 -0.477158523544161 0.00138539746274052 MirTarget;PITA;miRanda;miRNATAP -0.143026874546394 2.76474182066111e-05 NA NA NA hsa-miR-425-5p CAB39 3.07071373939774 4.02947460586085e-25 -0.477158523544161 0.00138539746274052 MirTarget -0.113641248897846 5.96290649580998e-07 NA NA NA hsa-miR-155-5p CAB39L 1.20164021433135 0.00086170622431261 -1.32713099101099 0.0016286153077432 miRNAWalker2_validate -0.465068952849233 1.19895211489865e-17 NA NA NA hsa-miR-214-5p CAB39L 0.962365243662358 0.0069147776948866 -1.32713099101099 0.0016286153077432 MirTarget -0.199486122647592 0.000482891477634037 NA NA NA hsa-miR-342-3p CAB39L 1.49115144672245 1.43879249744621e-07 -1.32713099101099 0.0016286153077432 miRanda -0.345811625519967 9.98604734821319e-07 NA NA NA hsa-miR-362-3p CAB39L 2.0756816987665 3.89026064579331e-12 -1.32713099101099 0.0016286153077432 miRanda -0.233526737377569 0.000701131740966757 NA NA NA hsa-miR-539-5p CAB39L 0.95216780650456 0.00284373332122135 -1.32713099101099 0.0016286153077432 mirMAP -0.156191725914134 0.0154148730579171 NA NA NA hsa-miR-590-3p CAB39L 2.59289455139753 1.03200520972022e-21 -1.32713099101099 0.0016286153077432 miRanda -0.271432757362025 0.000233995683821118 NA NA NA hsa-miR-590-5p CAB39L 3.18300989862077 2.06813568597893e-26 -1.32713099101099 0.0016286153077432 miRanda -0.216240907453537 0.00104450011172972 NA NA NA hsa-miR-7-1-3p CAB39L 1.84950311431067 1.25300363397654e-13 -1.32713099101099 0.0016286153077432 mirMAP -0.346297894182823 1.3001850315113e-05 NA NA NA hsa-miR-200c-3p CACNA1C 3.50132673580082 2.42716349086937e-15 -2.53203105122136 8.2041496030931e-11 MirTarget -0.436093474539072 1.71924843611962e-28 NA NA NA hsa-miR-200c-3p CALU 3.50132673580082 2.42716349086937e-15 -0.148100201074846 0.463184247628706 MirTarget -0.230686970082118 1.2951659506794e-31 NA NA NA hsa-miR-200c-3p CBL 3.50132673580082 2.42716349086937e-15 -0.309132961135003 0.0648412067348561 MirTarget;mirMAP -0.105782323761434 1.02635974205051e-09 NA NA NA hsa-miR-200c-3p CDK6 3.50132673580082 2.42716349086937e-15 -0.774202349805119 0.064787030605636 mirMAP -0.320385878451071 9.82419842455136e-14 NA NA NA hsa-miR-200c-3p CELF2 3.50132673580082 2.42716349086937e-15 -3.04719737979328 4.72041352009215e-15 mirMAP;miRNATAP -0.507522314324143 2.26364434641141e-39 NA NA NA hsa-miR-200c-3p CFL2 3.50132673580082 2.42716349086937e-15 -2.61712932503392 6.6876672984936e-21 MirTarget;miRNATAP -0.47775192139898 1.87065344817105e-77 23497265 We characterized one of the target genes of miR-200c CFL2 and demonstrated that CFL2 is overexpressed in aggressive breast cancer cell lines and can be significantly down-regulated by exogenous miR-200c breast cancer hsa-miR-200c-3p CHRDL1 3.50132673580082 2.42716349086937e-15 -6.14628787036669 1.26356425887682e-13 MirTarget -0.98650234374657 4.70579040070454e-32 NA NA NA hsa-miR-200c-3p CHST11 3.50132673580082 2.42716349086937e-15 0.53998313547079 0.231103989518921 mirMAP -0.40264937459085 1.14560011127373e-18 NA NA NA hsa-miR-200c-3p CIITA 3.50132673580082 2.42716349086937e-15 -0.0228897168841891 0.959678389546489 mirMAP -0.202127971747454 2.01835562533023e-05 NA NA NA hsa-miR-200c-3p CLIC4 3.50132673580082 2.42716349086937e-15 -1.72389310060141 6.21382968572505e-08 MirTarget;miRNATAP -0.456334265563461 6.59418212524645e-52 NA NA NA hsa-miR-200c-3p CLIP2 3.50132673580082 2.42716349086937e-15 -0.796927760614636 0.00157984633892106 MirTarget;miRNATAP -0.175775545212805 1.72562779319927e-11 NA NA NA hsa-miR-200c-3p CNN3 3.50132673580082 2.42716349086937e-15 -0.662842637540786 0.00534632089235666 MirTarget;miRNATAP -0.201796950162607 9.38690932877399e-17 NA NA NA hsa-miR-200c-3p CNTFR 3.50132673580082 2.42716349086937e-15 -3.85610534555259 4.26251450212736e-08 miRNATAP -0.437014825669292 4.0789929368456e-09 NA NA NA hsa-miR-200c-3p CNTN1 3.50132673580082 2.42716349086937e-15 -4.98280431564283 1.02293078354206e-09 MirTarget;miRNATAP -0.740154385698551 1.87627897077188e-18 NA NA NA hsa-miR-200c-3p CNTN4 3.50132673580082 2.42716349086937e-15 -3.05744404253524 2.33735855987774e-12 miRNATAP -0.190477586382324 5.13970306737113e-05 NA NA NA hsa-miR-200c-3p COL4A3 3.50132673580082 2.42716349086937e-15 -3.13816823718198 5.72507717181151e-07 miRNATAP -0.321328173209356 1.3577907991277e-06 NA NA NA hsa-miR-200c-3p COPS8 3.50132673580082 2.42716349086937e-15 -0.274921408047149 0.0139072510052669 MirTarget -0.109525312584179 9.05459223082766e-23 NA NA NA hsa-miR-200c-3p CORO1C 3.50132673580082 2.42716349086937e-15 -1.12142787999647 2.05016310243217e-07 MirTarget;miRNATAP -0.288905329274373 4.99892523482563e-44 NA NA NA hsa-miR-200c-3p CREB5 3.50132673580082 2.42716349086937e-15 -2.27679484644664 4.56595042875634e-09 miRNATAP -0.470215746107068 2.55597087862817e-34 NA NA NA hsa-miR-200c-3p CYP1B1 3.50132673580082 2.42716349086937e-15 -2.81828860701069 1.61767262798723e-06 miRNATAP -0.551390909310453 4.13814066664356e-20 25860934 Loss of miR 200c up regulates CYP1B1 and confers docetaxel resistance in renal cell carcinoma; Additionally miR-200c which is significantly down-regulated in RCC regulates CYP1B1 expression and activity; An inverse association was also observed between the expression levels of miR-200c and CYP1B1 protein in RCC tissues; Restoration of docetaxel resistance by exogenous expression of CYP1B1 in miR-200c-over-expressing cells indicates that CYP1B1 is a functional target of miR-200c; These results suggest that CYP1B1 up-regulation mediated by low miR-200c is one of the mechanisms underlying resistance of RCC cells to docetaxel; Therefore expression of CYP1B1 and miR-200c in RCC may be useful as a prediction for docetaxel response drug resistance kidney renal cell cancer hsa-miR-200c-3p CYTH3 3.50132673580082 2.42716349086937e-15 -0.272207622459217 0.193434635786576 MirTarget -0.171003717286142 1.06988133428323e-15 NA NA NA hsa-miR-200c-3p DACT1 3.50132673580082 2.42716349086937e-15 -1.78085143314576 2.05886005067419e-05 miRNATAP -0.468544911780467 1.83843895910496e-29 NA NA NA hsa-miR-200c-3p DCBLD2 3.50132673580082 2.42716349086937e-15 -0.127512036942836 0.735967995495379 MirTarget -0.310752657713804 7.31627359199509e-16 NA NA NA hsa-miR-101-3p DDIT4 0.522819989585461 0.00375627731618038 0.717938757137077 0.0430461225180125 miRNAWalker2_validate;MirTarget;miRNATAP -0.355155844720243 0.00021315858646136 NA NA NA hsa-miR-181c-5p DDIT4 1.58587920618301 1.57506918816933e-10 0.717938757137077 0.0430461225180125 MirTarget -0.145077871296069 0.0335547857337937 NA NA NA hsa-miR-181d-5p DDIT4 1.52204912185579 9.2693319057748e-08 0.717938757137077 0.0430461225180125 MirTarget -0.127310279952917 0.0330653294977689 NA NA NA hsa-miR-30b-5p DDIT4 0.800822374912712 0.000133601914525413 0.717938757137077 0.0430461225180125 MirTarget -0.231516620607933 0.00481015325205432 NA NA NA hsa-miR-30c-5p DDIT4 0.778774633108 0.000285599212429136 0.717938757137077 0.0430461225180125 MirTarget;miRNATAP -0.189580566588003 0.0182756104343371 NA NA NA hsa-miR-30d-5p DDIT4 0.675423997639582 0.00270618816039773 0.717938757137077 0.0430461225180125 MirTarget;miRNATAP -0.233442309312649 0.00227699320721357 NA NA NA hsa-miR-30e-5p DDIT4 1.23904909539663 1.35561917122157e-09 0.717938757137077 0.0430461225180125 MirTarget -0.279318696597116 0.000764635783021267 NA NA NA hsa-miR-32-5p DDIT4 2.34056473219422 6.24134585974322e-20 0.717938757137077 0.0430461225180125 miRNATAP -0.250841298923405 8.90809727205639e-05 NA NA NA hsa-miR-200c-3p DDIT4L 3.50132673580082 2.42716349086937e-15 -1.9019553090965 0.000465737260753943 MirTarget -0.467650323407764 4.09937437157122e-17 NA NA NA hsa-miR-200c-3p DENND5A 3.50132673580082 2.42716349086937e-15 -1.18678560113232 3.24357450546046e-11 MirTarget -0.249801332535579 7.95460413188994e-48 NA NA NA hsa-miR-200c-3p DENND5B 3.50132673580082 2.42716349086937e-15 -1.35091655519941 9.63273930805463e-05 MirTarget;miRNATAP -0.388782737688361 1.06463025647737e-29 NA NA NA hsa-miR-200c-3p DIAPH2 3.50132673580082 2.42716349086937e-15 -0.88549037173207 0.000371181170963573 mirMAP -0.107512804024802 4.18557089948089e-05 NA NA NA hsa-miR-200c-3p DIXDC1 3.50132673580082 2.42716349086937e-15 -3.01066558370526 1.36952954348107e-19 MirTarget -0.51565835630041 5.52676022504697e-59 NA NA NA hsa-miR-200c-3p DLC1 3.50132673580082 2.42716349086937e-15 -1.80446027708783 9.14505487509203e-10 miRNATAP -0.196371174380724 2.83097145908007e-10 NA NA NA hsa-miR-200c-3p DMD 3.50132673580082 2.42716349086937e-15 -3.69368719337714 3.87883942927561e-15 miRNATAP -0.530227342483484 2.76303130186155e-28 NA NA NA hsa-miR-200c-3p DNAJB5 3.50132673580082 2.42716349086937e-15 -2.65207059462743 2.68507855515511e-15 miRNATAP -0.523417573865588 8.66882403219181e-62 NA NA NA hsa-miR-200c-3p DOCK4 3.50132673580082 2.42716349086937e-15 -0.482456191440432 0.0791191956674349 MirTarget -0.216394616263008 1.42811223993013e-14 NA NA NA hsa-miR-200c-3p DRP2 3.50132673580082 2.42716349086937e-15 -1.34779224755633 0.000228883511200255 mirMAP -0.3120874276009 8.16166065202024e-17 NA NA NA hsa-miR-200c-3p DST 3.50132673580082 2.42716349086937e-15 -1.11542714896545 9.14769438027749e-05 mirMAP -0.104545025716321 0.000541561844338111 NA NA NA hsa-miR-200c-3p DTNA 3.50132673580082 2.42716349086937e-15 -4.06049121456747 1.59577306327407e-12 MirTarget -0.646651183559355 1.51981975883497e-28 NA NA NA hsa-miR-200c-3p DUSP1 3.50132673580082 2.42716349086937e-15 -3.47418646928724 1.98436002754553e-20 MirTarget;miRNATAP -0.31571143226552 4.3503827266648e-15 NA NA NA hsa-miR-200c-3p DYNC1I1 3.50132673580082 2.42716349086937e-15 -2.0457299899893 0.00010088277927843 MirTarget -0.198092464250846 0.000383313936695602 NA NA NA hsa-miR-200c-3p DZIP1 3.50132673580082 2.42716349086937e-15 -1.57008196403815 1.8435672027566e-05 MirTarget -0.337163109371172 1.97667084535266e-19 NA NA NA hsa-miR-200c-3p EDNRA 3.50132673580082 2.42716349086937e-15 -2.18719306101688 8.33789654397051e-10 miRNAWalker2_validate;miRNATAP -0.429900561340471 6.58562337198449e-34 NA NA NA hsa-miR-103a-3p EIF4B 1.44083190496858 1.53799939616416e-13 -0.83546386425099 1.60081741236658e-10 MirTarget;miRNATAP -0.12384012181884 0.000120527401673825 NA NA NA hsa-miR-107 EIF4B 1.30977326593435 1.30372468603965e-11 -0.83546386425099 1.60081741236658e-10 MirTarget;PITA;miRanda;miRNATAP -0.116267081967539 0.000376104753401664 NA NA NA hsa-miR-15a-5p EIF4B 2.34669284378787 1.69544424500258e-23 -0.83546386425099 1.60081741236658e-10 miRNATAP -0.115102898094679 8.58712735181583e-06 NA NA NA hsa-miR-15b-5p EIF4B 1.57112623124278 9.14247846750597e-13 -0.83546386425099 1.60081741236658e-10 miRNATAP -0.108417564399088 0.000145863770523161 NA NA NA hsa-miR-16-5p EIF4B 1.75824877145857 1.68592440033108e-16 -0.83546386425099 1.60081741236658e-10 miRNAWalker2_validate;MirTarget;miRNATAP -0.116626867681087 6.27326636466319e-05 NA NA NA hsa-miR-185-5p EIF4B 2.34016206907488 1.17481626642022e-26 -0.83546386425099 1.60081741236658e-10 MirTarget -0.163628340278415 2.05665506314812e-09 NA NA NA hsa-miR-193a-3p EIF4B 1.60460546928078 2.86169793322984e-07 -0.83546386425099 1.60081741236658e-10 miRanda -0.129748653727289 7.39065685686338e-11 NA NA NA hsa-miR-193b-3p EIF4B 2.25711804611899 4.1940744806631e-14 -0.83546386425099 1.60081741236658e-10 miRNAWalker2_validate -0.131575191324763 1.39505544343809e-10 NA NA NA hsa-miR-25-3p EIF4B 1.36472605225697 4.83790725935681e-11 -0.83546386425099 1.60081741236658e-10 miRNAWalker2_validate -0.106392733880944 0.000481532722887453 NA NA NA hsa-miR-342-3p EIF4B 1.49115144672245 1.43879249744621e-07 -0.83546386425099 1.60081741236658e-10 miRanda -0.126332356229928 1.1049251414087e-08 NA NA NA hsa-miR-362-3p EIF4B 2.0756816987665 3.89026064579331e-12 -0.83546386425099 1.60081741236658e-10 miRanda -0.161499044149002 1.7968030077065e-14 NA NA NA hsa-miR-423-3p EIF4B 2.57855385753676 9.19765570228097e-24 -0.83546386425099 1.60081741236658e-10 miRNAWalker2_validate -0.131931378309889 1.88384562098769e-08 NA NA NA hsa-miR-424-5p EIF4B 1.61930224569578 1.89642549274994e-10 -0.83546386425099 1.60081741236658e-10 miRNATAP -0.129745405637866 1.30304622694912e-07 NA NA NA hsa-miR-484 EIF4B 1.81844463411787 1.82951571230938e-15 -0.83546386425099 1.60081741236658e-10 miRNAWalker2_validate -0.115522506643854 2.13739109619376e-05 NA NA NA hsa-miR-532-3p EIF4B 1.96631878320218 4.53421954361695e-13 -0.83546386425099 1.60081741236658e-10 miRNATAP -0.138783439415054 9.6358571664864e-10 NA NA NA hsa-miR-590-3p EIF4B 2.59289455139753 1.03200520972022e-21 -0.83546386425099 1.60081741236658e-10 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.10810967510776 2.80808517421654e-06 NA NA NA hsa-miR-200c-3p ELL2 3.50132673580082 2.42716349086937e-15 -1.08408930026814 1.18240618311454e-05 MirTarget -0.125624172249391 1.49662582237983e-06 NA NA NA hsa-miR-200c-3p ENTPD1 3.50132673580082 2.42716349086937e-15 -1.12219223948292 8.05257550730918e-10 MirTarget;mirMAP -0.242553477574852 1.25234085734162e-42 NA NA NA hsa-miR-200c-3p ERC1 3.50132673580082 2.42716349086937e-15 -1.0981015647741 3.01720605629387e-09 mirMAP -0.169927644147619 4.90694981992114e-19 NA NA NA hsa-miR-200c-3p ETS1 3.50132673580082 2.42716349086937e-15 -0.699528618233348 0.00228038287696191 MirTarget;miRNATAP -0.128822600745719 7.61112410894651e-08 NA NA NA hsa-miR-200c-3p ETV5 3.50132673580082 2.42716349086937e-15 0.236527120804439 0.423051410174547 MirTarget;miRNATAP -0.203619656408979 2.22974291370174e-11 27276064 Another study suggested that ERM expression was regulated directly by miR-200c and had a critical role in miR-200c suppressing cell migration cell migration breast cancer hsa-miR-200c-3p EXT1 3.50132673580082 2.42716349086937e-15 0.128948722299907 0.573712409186736 mirMAP -0.120220274695418 4.78122263653565e-07 NA NA NA hsa-miR-200c-3p F2RL2 3.50132673580082 2.42716349086937e-15 -0.074170778593706 0.882857232515843 MirTarget -0.402243298496942 5.13495429583168e-15 NA NA NA hsa-miR-200c-3p FAT3 3.50132673580082 2.42716349086937e-15 -2.79096679677476 3.40343867448209e-06 MirTarget;miRNATAP -0.234039279680735 0.000251033036038252 NA NA NA hsa-miR-200c-3p FBLN5 3.50132673580082 2.42716349086937e-15 -2.7572810002915 1.11240697718667e-13 miRNAWalker2_validate;miRTarBase -0.400109932439159 7.56529266726843e-26 NA NA NA hsa-miR-200c-3p FGD1 3.50132673580082 2.42716349086937e-15 -0.0471679512075118 0.859636723526689 miRNATAP -0.176696411492912 1.39557182757149e-10 NA NA NA hsa-miR-200c-3p FGF18 3.50132673580082 2.42716349086937e-15 -1.42483047022124 0.00103718898766565 miRNATAP -0.257330688592158 1.44969551897125e-08 NA NA NA hsa-miR-200c-3p FGF2 3.50132673580082 2.42716349086937e-15 -3.45935256477983 3.20406041037898e-17 mirMAP -0.581898672989235 1.2281612826909e-47 NA NA NA hsa-miR-200c-3p FHL1 3.50132673580082 2.42716349086937e-15 -4.79489740738213 4.58621609455402e-20 MirTarget -0.777950964097711 1.07858115739551e-52 NA NA NA hsa-miR-200c-3p FHOD1 3.50132673580082 2.42716349086937e-15 0.606822113176475 0.000711612899453606 miRNAWalker2_validate -0.107419840638149 9.12437900743461e-09 22144583 MicroRNA 200c represses migration and invasion of breast cancer cells by targeting actin regulatory proteins FHOD1 and PPM1F; We identified FHOD1 and PPM1F direct regulators of the actin cytoskeleton as novel targets of miR-200c; Remarkably expression levels of FHOD1 and PPM1F were inversely correlated with the level of miR-200c in breast cancer cell lines breast cancer patient samples and 58 cancer cell lines of various origins breast cancer hsa-miR-200c-3p FKBP14 3.50132673580082 2.42716349086937e-15 0.0327877092565507 0.867884467649625 mirMAP -0.116653645937896 1.1313070245364e-08 NA NA NA hsa-miR-200c-3p FLI1 3.50132673580082 2.42716349086937e-15 -1.10881984531465 6.56713737767845e-05 MirTarget;miRNATAP -0.315112566669429 2.08862569284463e-30 NA NA NA hsa-miR-200c-3p FLNA 3.50132673580082 2.42716349086937e-15 -2.62738684988354 4.5847076562045e-13 miRNAWalker2_validate -0.573278326556171 6.53243471319789e-65 NA NA NA hsa-miR-200c-3p FN1 3.50132673580082 2.42716349086937e-15 -0.407678263046535 0.457934813442308 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.661896693895972 1.64136219365611e-35 NA NA NA hsa-miR-200c-3p FOXF1 3.50132673580082 2.42716349086937e-15 -3.59969497191247 8.05975763421163e-22 MirTarget -0.332527775439702 1.38577657244357e-16 NA NA NA hsa-miR-200c-3p FSTL1 3.50132673580082 2.42716349086937e-15 -1.20409366079041 3.08470468877507e-05 MirTarget -0.363468259803467 2.09035802399296e-38 NA NA NA hsa-miR-200c-3p FUNDC2 3.50132673580082 2.42716349086937e-15 -0.540715808942645 1.0105042632278e-05 mirMAP -0.121594306752915 5.89365481587959e-23 NA NA NA hsa-miR-200c-3p FYN 3.50132673580082 2.42716349086937e-15 -1.46508592139092 9.74677213788621e-08 miRNATAP -0.35092340815277 3.35510281801253e-39 NA NA NA hsa-miR-200c-3p FZD4 3.50132673580082 2.42716349086937e-15 -0.82842258037894 0.00067769989049317 mirMAP -0.112009526076228 1.27368925786649e-05 NA NA NA hsa-miR-200c-3p GATA4 3.50132673580082 2.42716349086937e-15 0.21063442916978 0.736053452717422 MirTarget;miRNATAP -0.254174058833087 0.000106333228523155 NA NA NA hsa-miR-200c-3p GEM 3.50132673580082 2.42716349086937e-15 -3.69134770515528 5.61525969896728e-16 MirTarget;miRNATAP -0.59591901710192 2.64134984555771e-39 NA NA NA hsa-miR-200c-3p GFI1 3.50132673580082 2.42716349086937e-15 0.348773110565043 0.374815763211957 miRNATAP -0.13817000467087 0.000831176064758985 NA NA NA hsa-miR-200c-3p GFRA1 3.50132673580082 2.42716349086937e-15 -4.99535302188274 6.14065741522982e-16 mirMAP -0.326378196591011 1.11002175660837e-06 NA NA NA hsa-miR-200c-3p GJA3 3.50132673580082 2.42716349086937e-15 0.723342716596257 0.205005185873009 mirMAP -0.159359701759363 0.00815220732632135 NA NA NA hsa-miR-200c-3p GJC1 3.50132673580082 2.42716349086937e-15 -0.972020676723743 0.00222017431601357 MirTarget;miRNATAP -0.312348068065492 1.57157651177237e-22 NA NA NA hsa-miR-200c-3p GLI3 3.50132673580082 2.42716349086937e-15 -0.852256004040062 0.0202428205589312 miRNATAP -0.215624593712126 1.72674225472266e-08 NA NA NA hsa-miR-200c-3p GLIS2 3.50132673580082 2.42716349086937e-15 -0.610818722003668 0.0527901481345749 miRNATAP -0.314830299269461 1.99437681270576e-23 NA NA NA hsa-miR-200c-3p GLRX 3.50132673580082 2.42716349086937e-15 -0.275147826859437 0.316770480646163 MirTarget -0.167349180181311 4.33729502224369e-09 NA NA NA hsa-miR-200c-3p GNG4 3.50132673580082 2.42716349086937e-15 0.216159437363437 0.744682539041036 mirMAP -0.415747931208297 1.50663821120222e-09 NA NA NA hsa-miR-200c-3p GPM6A 3.50132673580082 2.42716349086937e-15 -4.42956657098415 1.14589092196157e-14 miRNATAP -0.612078374655501 3.81550733224843e-25 NA NA NA hsa-miR-200c-3p GPR146 3.50132673580082 2.42716349086937e-15 -1.48603298566623 8.59493020531833e-12 miRNATAP -0.180580311996315 2.30119345589293e-15 NA NA NA hsa-miR-200c-3p GPRASP2 3.50132673580082 2.42716349086937e-15 -1.4590659609289 3.45285620607504e-12 MirTarget -0.184563271399617 3.21750849985113e-17 NA NA NA hsa-miR-200c-3p GREM1 3.50132673580082 2.42716349086937e-15 0.08752650759248 0.914525538097529 MirTarget -0.651094007307394 5.51115376486247e-15 NA NA NA hsa-miR-200c-3p HCFC2 3.50132673580082 2.42716349086937e-15 -0.813476452597869 3.14714018131552e-07 miRNATAP -0.124569233080298 4.14807035121159e-14 NA NA NA hsa-miR-200c-3p HDAC4 3.50132673580082 2.42716349086937e-15 -1.80036091395253 1.96398022917234e-18 miRNATAP -0.259928770853832 5.69329528676252e-36 NA NA NA hsa-miR-106b-3p HIF1A 1.74115042407425 7.96524575137272e-14 -0.0887083952652183 0.694448347585856 miRNAWalker2_validate -0.115876573349366 0.01114041942823 NA NA NA hsa-miR-106b-5p HIF1A 2.46782146831112 1.36171495805632e-23 -0.0887083952652183 0.694448347585856 MirTarget -0.22506470406352 5.67731754915871e-08 NA NA NA hsa-miR-107 HIF1A 1.30977326593435 1.30372468603965e-11 -0.0887083952652183 0.694448347585856 miRNAWalker2_validate;miRTarBase;miRanda -0.123422589068387 0.0264755744668062 NA NA NA hsa-miR-151a-3p HIF1A 1.24018761527407 1.08839919675408e-07 -0.0887083952652183 0.694448347585856 MirTarget -0.16533909856988 0.000338305910074446 NA NA NA hsa-miR-20a-5p HIF1A 3.15577933619191 4.19753346442454e-25 -0.0887083952652183 0.694448347585856 miRNAWalker2_validate;miRTarBase;MirTarget -0.115406855575695 0.000600547799598935 22901144 Correlation analysis showed that the key miRNAs miR-20a and miR-20b negatively correlated with the target proteins VEGF-A and HIF-1alpha breast cancer hsa-miR-28-5p HIF1A 0.230152919654905 0.0742909586754846 -0.0887083952652183 0.694448347585856 miRanda -0.410823482574077 2.0450455286232e-06 NA NA NA hsa-miR-330-3p HIF1A 0.876747334239085 0.00073709016089703 -0.0887083952652183 0.694448347585856 MirTarget;PITA -0.100136266436928 0.0170482873133228 NA NA NA hsa-miR-361-5p HIF1A 0.971859117235239 5.30236555707088e-09 -0.0887083952652183 0.694448347585856 miRanda -0.240248110278126 0.00022502129165918 NA NA NA hsa-miR-660-5p HIF1A 1.82692095272076 1.92040083607196e-13 -0.0887083952652183 0.694448347585856 MirTarget -0.138381785632354 0.00119715434144136 NA NA NA hsa-miR-93-5p HIF1A 3.03961860136032 1.11672209617395e-24 -0.0887083952652183 0.694448347585856 MirTarget -0.194707893705988 1.28811205175096e-08 NA NA NA hsa-miR-200c-3p HIPK3 3.50132673580082 2.42716349086937e-15 -1.74508965708072 2.92750932105647e-06 MirTarget -0.181375750035182 4.43648446216615e-06 NA NA NA hsa-miR-200c-3p HIVEP3 3.50132673580082 2.42716349086937e-15 0.0288071997334853 0.920325184162576 miRNATAP -0.205021380547737 4.48369730907305e-12 NA NA NA hsa-miR-200c-3p HLF 3.50132673580082 2.42716349086937e-15 -5.48181644757567 4.24267397704754e-28 MirTarget;miRNATAP -0.598575582470935 4.30883090987262e-30 NA NA NA hsa-miR-200c-3p HPS5 3.50132673580082 2.42716349086937e-15 -0.387841491492044 0.0146097312589973 MirTarget -0.118001047291785 4.68258293953271e-13 NA NA NA hsa-miR-200c-3p HS3ST3A1 3.50132673580082 2.42716349086937e-15 -0.129308279745747 0.831566302453219 MirTarget -0.629342883381929 2.19650792869416e-25 NA NA NA hsa-miR-200c-3p HUNK 3.50132673580082 2.42716349086937e-15 -2.26986927474702 1.0712218399358e-05 mirMAP -0.232558300822558 2.06932756428887e-05 NA NA NA hsa-miR-200c-3p IFIT5 3.50132673580082 2.42716349086937e-15 -0.142910091937379 0.549505921470859 miRNATAP -0.130149067809263 1.62593220739266e-07 NA NA NA hsa-let-7a-3p IGF1 1.42015538786275 7.03375209382654e-13 -3.75951127345565 1.26264890381366e-10 mirMAP -0.92426917804667 5.0725450948492e-11 NA NA NA hsa-let-7a-5p IGF1 0.618599506841644 2.76973453058748e-05 -3.75951127345565 1.26264890381366e-10 TargetScan -1.35484578107079 3.03432417502265e-12 NA NA NA hsa-let-7b-3p IGF1 0.868207752019623 1.30460056774366e-05 -3.75951127345565 1.26264890381366e-10 mirMAP -0.806527950481254 1.86996353532323e-08 NA NA NA hsa-let-7f-1-3p IGF1 1.55054488387679 7.31326775537952e-11 -3.75951127345565 1.26264890381366e-10 mirMAP -0.53583367534408 1.14955943868674e-05 NA NA NA hsa-miR-103a-2-5p IGF1 2.47599305985086 7.933028987326e-11 -3.75951127345565 1.26264890381366e-10 mirMAP -0.672288935268143 1.21134250789966e-16 NA NA NA hsa-miR-129-5p IGF1 -0.524170159980738 0.222582956006346 -3.75951127345565 1.26264890381366e-10 MirTarget;PITA;miRanda -0.24872412851026 0.000279350666200339 NA NA NA hsa-miR-130a-3p IGF1 2.02021855058359 1.26427102520415e-11 -3.75951127345565 1.26264890381366e-10 MirTarget -0.315325422858442 0.000861190344159203 NA NA NA hsa-miR-130b-3p IGF1 3.5350292994509 1.73934183852569e-27 -3.75951127345565 1.26264890381366e-10 MirTarget -0.781941096991651 4.63853079450254e-23 NA NA NA hsa-miR-148a-5p IGF1 1.16173838132242 0.000148929299881612 -3.75951127345565 1.26264890381366e-10 mirMAP -0.212992981754178 0.0236997428556886 NA NA NA hsa-miR-15b-3p IGF1 2.33847028227712 4.29662877950836e-19 -3.75951127345565 1.26264890381366e-10 mirMAP -1.14217010288885 5.28861971423639e-31 NA NA NA hsa-miR-16-1-3p IGF1 2.56983217111073 3.02262181237943e-20 -3.75951127345565 1.26264890381366e-10 mirMAP -0.921958602704484 2.5787665170735e-21 NA NA NA hsa-miR-181a-5p IGF1 2.29556023480783 1.8138457900616e-21 -3.75951127345565 1.26264890381366e-10 mirMAP -0.642043297035051 1.32592036628183e-08 NA NA NA hsa-miR-181b-5p IGF1 2.49307679431293 3.92829250217627e-20 -3.75951127345565 1.26264890381366e-10 mirMAP -0.697159274066391 2.64064192584975e-12 NA NA NA hsa-miR-181c-5p IGF1 1.58587920618301 1.57506918816933e-10 -3.75951127345565 1.26264890381366e-10 mirMAP -0.418006737238249 0.00025755851863695 NA NA NA hsa-miR-186-5p IGF1 1.47445398888668 3.0781726595413e-15 -3.75951127345565 1.26264890381366e-10 mirMAP -1.20504446214237 1.61828209547411e-16 NA NA NA hsa-miR-19a-3p IGF1 3.42309334186656 3.02671914353412e-28 -3.75951127345565 1.26264890381366e-10 MirTarget -0.788529625251502 2.31580352219079e-21 NA NA NA hsa-miR-19b-1-5p IGF1 2.57951428759379 4.31576118703427e-20 -3.75951127345565 1.26264890381366e-10 mirMAP -0.995592930242643 1.89907484758614e-25 NA NA NA hsa-miR-19b-3p IGF1 2.49529833021187 1.57028265846699e-23 -3.75951127345565 1.26264890381366e-10 MirTarget -1.0369004238185 3.24569264936101e-23 NA NA NA hsa-miR-20a-3p IGF1 2.92621109947706 2.49504904635375e-17 -3.75951127345565 1.26264890381366e-10 mirMAP -0.809636638775284 3.3899709447565e-25 NA NA NA hsa-miR-224-3p IGF1 1.87536386559317 6.15140969394846e-05 -3.75951127345565 1.26264890381366e-10 mirMAP -0.362328718988192 1.01049263740062e-08 NA NA NA hsa-miR-26b-5p IGF1 0.885393662798425 3.2116297961629e-06 -3.75951127345565 1.26264890381366e-10 mirMAP -0.940665920848216 3.14292070875382e-10 NA NA NA hsa-miR-27a-3p IGF1 1.66542180327138 4.93775737894805e-13 -3.75951127345565 1.26264890381366e-10 miRNAWalker2_validate;miRTarBase -0.651692554274928 7.73576562076687e-08 NA NA NA hsa-miR-29b-3p IGF1 1.65828197923813 1.02676780888141e-09 -3.75951127345565 1.26264890381366e-10 MirTarget -0.519110555190393 5.59140789276621e-07 25592039 Luciferase reporter assays were conducted to determine the association between miR-29b and the insulin-like growth factor 1 IGF1 3' untranslated region 3'UTR; IGF1 an activator of PI3K/Akt signaling was confirmed as a novel target of miR-29b colorectal cancer hsa-miR-301a-3p IGF1 2.81024345929638 2.29784847962242e-17 -3.75951127345565 1.26264890381366e-10 MirTarget -0.801898835472881 2.70419582744703e-21 NA NA NA hsa-miR-3065-5p IGF1 2.74629919868982 1.86846589298284e-08 -3.75951127345565 1.26264890381366e-10 mirMAP -0.340906479396581 1.44245852597366e-06 NA NA NA hsa-miR-32-3p IGF1 2.02436999565685 5.94091197945307e-09 -3.75951127345565 1.26264890381366e-10 mirMAP -0.670318737511073 1.52748719371215e-13 NA NA NA hsa-miR-320a IGF1 0.438165828017084 0.0390159073347133 -3.75951127345565 1.26264890381366e-10 miRNATAP -0.87110280497324 9.95766777508728e-11 NA NA NA hsa-miR-320b IGF1 1.55692969039548 1.41071034251915e-08 -3.75951127345565 1.26264890381366e-10 miRNATAP -0.993279990978514 6.22780218264885e-24 NA NA NA hsa-miR-33a-3p IGF1 1.72765312072219 1.51784443453521e-07 -3.75951127345565 1.26264890381366e-10 MirTarget -0.862622681654972 2.52525229105421e-21 NA NA NA hsa-miR-3607-3p IGF1 2.68532138541128 5.66716351955047e-14 -3.75951127345565 1.26264890381366e-10 mirMAP -0.646493669321152 1.00233762873621e-16 NA NA NA hsa-miR-361-5p IGF1 0.971859117235239 5.30236555707088e-09 -3.75951127345565 1.26264890381366e-10 PITA;mirMAP -1.48168691679158 5.53863901928066e-19 NA NA NA hsa-miR-374b-3p IGF1 0.930487774873495 2.74420094310516e-05 -3.75951127345565 1.26264890381366e-10 mirMAP -0.498455115159369 0.000129551554566347 NA NA NA hsa-miR-3913-5p IGF1 2.44353493655328 8.95279496632448e-15 -3.75951127345565 1.26264890381366e-10 mirMAP -0.584661382885468 7.3573353974355e-11 NA NA NA hsa-miR-421 IGF1 1.17791565395543 6.78526676976629e-06 -3.75951127345565 1.26264890381366e-10 PITA -0.696572691037999 1.11839961387445e-10 NA NA NA hsa-miR-452-5p IGF1 1.37180058737183 0.00171494843537772 -3.75951127345565 1.26264890381366e-10 MirTarget;mirMAP -0.239891308263067 0.000253591244736158 NA NA NA hsa-miR-454-3p IGF1 2.47234127820054 1.12878018736016e-21 -3.75951127345565 1.26264890381366e-10 MirTarget -0.897384141255581 2.08224455125487e-17 NA NA NA hsa-miR-486-5p IGF1 -0.194913133034028 0.607377798807705 -3.75951127345565 1.26264890381366e-10 PITA;miRNATAP -0.336416232300254 9.17459110593128e-06 NA NA NA hsa-miR-576-5p IGF1 2.20467023993664 3.4053475193793e-19 -3.75951127345565 1.26264890381366e-10 PITA;mirMAP;miRNATAP -1.00551072603292 1.14064166854676e-20 NA NA NA hsa-miR-590-3p IGF1 2.59289455139753 1.03200520972022e-21 -3.75951127345565 1.26264890381366e-10 MirTarget;miRanda;mirMAP;miRNATAP -0.845684857318828 5.27514597787573e-17 NA NA NA hsa-miR-592 IGF1 1.51765968871077 0.000636335248013204 -3.75951127345565 1.26264890381366e-10 mirMAP -0.450455314337535 2.70073065710591e-12 NA NA NA hsa-miR-629-5p IGF1 2.10182419359635 1.51788571125757e-15 -3.75951127345565 1.26264890381366e-10 mirMAP -0.693559501922869 2.74994850835533e-11 NA NA NA hsa-miR-664a-3p IGF1 0.634721925861133 0.00520070178640421 -3.75951127345565 1.26264890381366e-10 mirMAP -0.350873716989665 0.00610206128936229 NA NA NA hsa-miR-940 IGF1 3.21011374578759 2.7923171128495e-14 -3.75951127345565 1.26264890381366e-10 MirTarget;PITA;miRNATAP -0.715084793572266 1.27978685880086e-25 NA NA NA hsa-miR-200c-3p IGSF10 3.50132673580082 2.42716349086937e-15 -5.30237641574688 9.03000767899905e-16 MirTarget -0.543470626925824 8.24252002226486e-15 NA NA NA hsa-miR-200c-3p IL6ST 3.50132673580082 2.42716349086937e-15 -2.09967019941458 1.93264814611531e-05 mirMAP -0.351735931542591 6.11651430778903e-12 NA NA NA hsa-miR-200c-3p ITGA1 3.50132673580082 2.42716349086937e-15 -1.43194652766846 3.62878143052896e-06 MirTarget -0.340248985237553 3.10844394076231e-28 NA NA NA hsa-miR-200c-3p ITPR1 3.50132673580082 2.42716349086937e-15 -2.58213364075087 3.81753054779227e-18 miRNATAP -0.31074820203156 1.2207549117247e-23 NA NA NA hsa-miR-200c-3p ITPR2 3.50132673580082 2.42716349086937e-15 -0.177554271932524 0.436106439712671 MirTarget -0.148029930319774 3.31118529911441e-10 NA NA NA hsa-miR-200c-3p JAZF1 3.50132673580082 2.42716349086937e-15 -1.91995536790338 5.72076669427973e-12 MirTarget;miRNATAP -0.417363984218602 1.18716870274506e-56 NA NA NA hsa-miR-200c-3p JUN 3.50132673580082 2.42716349086937e-15 -2.04611084807692 9.1524625995215e-13 MirTarget -0.195019704023245 1.57363395803084e-10 NA NA NA hsa-miR-200c-3p KCNJ2 3.50132673580082 2.42716349086937e-15 -0.281197518883409 0.36164514317052 miRNATAP -0.124610651814908 0.000116946913854337 NA NA NA hsa-miR-200c-3p KCNK2 3.50132673580082 2.42716349086937e-15 -3.96205468288205 7.92099572968654e-12 miRNATAP -0.50213809450649 1.09916918435836e-16 NA NA NA hsa-miR-200c-3p KCNQ4 3.50132673580082 2.42716349086937e-15 -2.63982014948538 9.7947726847549e-09 miRNATAP -0.358302675169609 9.31183107328647e-14 NA NA NA hsa-miR-200c-3p KCTD15 3.50132673580082 2.42716349086937e-15 -1.06705874417742 0.00366825813765896 MirTarget;miRNATAP -0.220435916662502 8.7146531556752e-09 NA NA NA hsa-miR-200c-3p KDR 3.50132673580082 2.42716349086937e-15 -0.809645188569233 0.00140156336172476 miRNATAP -0.100553706909197 0.000169957263481419 24205206 MiR 200c increases the radiosensitivity of non small cell lung cancer cell line A549 by targeting VEGF VEGFR2 pathway; MiR-200c at the nexus of epithelial-mesenchymal transition EMT is predicted to target VEGFR2; The purpose of this study is to test the hypothesis that regulation of VEGFR2 pathway by miR-200c could modulate the radiosensitivity of cancer cells; Bioinformatic analysis luciferase reporter assays and biochemical assays were carried out to validate VEGFR2 as a direct target of miR-200c; We identified VEGFR2 as a novel target of miR-200c lung squamous cell cancer hsa-miR-200c-3p KIAA1462 3.50132673580082 2.42716349086937e-15 -1.7207439664468 1.06773819784283e-07 MirTarget -0.390952395751051 2.06195319565717e-34 NA NA NA hsa-miR-200c-3p KIF13A 3.50132673580082 2.42716349086937e-15 -1.2222279491778 3.03312683064576e-07 miRNATAP -0.122766402832361 1.18858226926387e-06 NA NA NA hsa-miR-200c-3p KLF10 3.50132673580082 2.42716349086937e-15 -1.1318994696032 3.44782858605802e-06 miRNATAP -0.184441147618597 3.18068583459059e-13 NA NA NA hsa-miR-200c-3p KLF11 3.50132673580082 2.42716349086937e-15 -0.893024981436906 6.97406562236998e-06 miRNAWalker2_validate -0.110383564384376 1.28195112464854e-07 NA NA NA hsa-miR-200c-3p KLF13 3.50132673580082 2.42716349086937e-15 -1.16141618366409 1.36372480238947e-05 miRNATAP -0.223148359199938 4.62619342254457e-16 NA NA NA hsa-miR-200c-3p KLF4 3.50132673580082 2.42716349086937e-15 -2.66899133268835 3.11667300306613e-16 MirTarget;miRNATAP -0.109582875233884 0.00217318206296219 NA NA NA hsa-miR-200c-3p KLF9 3.50132673580082 2.42716349086937e-15 -2.78806270116525 1.14874620908535e-18 miRNAWalker2_validate;miRTarBase;miRNATAP -0.399931620637291 7.36174043539773e-36 NA NA NA hsa-miR-200c-3p KLHDC1 3.50132673580082 2.42716349086937e-15 -1.73790146573647 5.50971604888164e-11 MirTarget -0.116365121245843 4.36458789969234e-05 NA NA NA hsa-miR-200c-3p LAMC1 3.50132673580082 2.42716349086937e-15 -0.820359806292778 9.59613230767155e-05 MirTarget;miRNATAP -0.189567753679175 8.99034744541273e-19 NA NA NA hsa-miR-200c-3p LATS2 3.50132673580082 2.42716349086937e-15 -1.50195936145544 2.88260453000506e-11 miRNATAP -0.25601848144934 2.48894504027114e-29 NA NA NA hsa-miR-200c-3p LHFP 3.50132673580082 2.42716349086937e-15 -1.83125704677191 4.20141501543429e-10 MirTarget;miRNATAP -0.360296521299789 2.49193500017075e-35 NA NA NA hsa-miR-200c-3p LIX1L 3.50132673580082 2.42716349086937e-15 -1.29493279298234 2.01115053124561e-08 MirTarget -0.343384608216057 3.2644648024768e-57 NA NA NA hsa-miR-200c-3p LPAR1 3.50132673580082 2.42716349086937e-15 -1.92450185312715 3.73367853480122e-09 miRNAWalker2_validate;MirTarget;miRNATAP -0.184541391970303 1.02192042157423e-07 NA NA NA hsa-miR-200c-3p LPIN1 3.50132673580082 2.42716349086937e-15 -0.89601675169461 0.000133989377531311 MirTarget -0.167389112818983 6.05721390462058e-12 NA NA NA hsa-miR-200c-3p MAF 3.50132673580082 2.42716349086937e-15 -1.28341922239874 0.00015825213662883 miRNATAP -0.35679417285462 9.60044419984967e-26 NA NA NA hsa-miR-200c-3p MAP2 3.50132673580082 2.42716349086937e-15 -0.753572928246066 0.0970780637395552 MirTarget;miRNATAP -0.257792003422747 5.10723168629245e-08 NA NA NA hsa-miR-140-3p MAPK1 0.0608890720479334 0.727716871248724 -0.300413846088826 0.0202503240217449 PITA;miRNATAP -0.126850675206772 0.000457308593536618 NA NA NA hsa-miR-30c-5p MAPK1 0.778774633108 0.000285599212429136 -0.300413846088826 0.0202503240217449 mirMAP -0.161696427374548 1.83237959021178e-08 NA NA NA hsa-miR-30e-5p MAPK1 1.23904909539663 1.35561917122157e-09 -0.300413846088826 0.0202503240217449 mirMAP -0.123981973754552 3.68994437193015e-05 NA NA NA hsa-miR-34a-5p MAPK1 1.9016323452565 1.43092834643601e-14 -0.300413846088826 0.0202503240217449 mirMAP -0.113934200811126 2.89029232507908e-06 NA NA NA hsa-miR-200c-3p MARCH1 3.50132673580082 2.42716349086937e-15 0.249895584717324 0.347593448523703 MirTarget -0.18533085182802 1.3644751877114e-11 NA NA NA hsa-miR-200c-3p MARCH8 3.50132673580082 2.42716349086937e-15 -0.883350326074423 0.00115126355540274 MirTarget -0.122969126976633 1.72281063834122e-05 NA NA NA hsa-miR-200c-3p MBNL1 3.50132673580082 2.42716349086937e-15 -1.03715217368983 1.91023114600054e-14 miRNATAP -0.146834845139787 2.78385451063201e-26 NA NA NA hsa-miR-200c-3p MCFD2 3.50132673580082 2.42716349086937e-15 -0.273710952309139 0.0802130111446696 MirTarget -0.12819612269317 8.21003055750594e-16 NA NA NA hsa-miR-200c-3p MEF2D 3.50132673580082 2.42716349086937e-15 -1.254473345286 3.30937184393369e-26 mirMAP -0.141713246594008 1.44643390522484e-30 NA NA NA hsa-miR-200c-3p MEGF10 3.50132673580082 2.42716349086937e-15 -0.573869708612628 0.230704357125925 MirTarget -0.148472724346704 0.0032645910758475 NA NA NA hsa-miR-200c-3p MEX3B 3.50132673580082 2.42716349086937e-15 0.132596726412779 0.712673599662109 miRNATAP -0.211675745417146 1.51022537157754e-08 NA NA NA hsa-miR-200c-3p MFAP5 3.50132673580082 2.42716349086937e-15 -4.35255383201982 2.63926165947326e-07 miRNATAP -0.904430228024108 2.48772724952338e-26 NA NA NA hsa-miR-200c-3p MITF 3.50132673580082 2.42716349086937e-15 -2.11043666647908 2.14681139044162e-09 miRNATAP -0.370919113758088 3.74236352265043e-25 NA NA NA hsa-miR-200c-3p MMD 3.50132673580082 2.42716349086937e-15 -0.0500962943374854 0.870546787744501 miRNATAP -0.308170884248988 9.44343148595576e-24 NA NA NA hsa-miR-200c-3p MMGT1 3.50132673580082 2.42716349086937e-15 -0.68742046704414 1.47427584314027e-05 MirTarget -0.136129522367508 5.42287995510645e-17 NA NA NA hsa-miR-200c-3p MPDZ 3.50132673580082 2.42716349086937e-15 -1.47308852519181 6.37797234153348e-08 MirTarget -0.205162160438677 5.35039020193225e-13 NA NA NA hsa-miR-200c-3p MRVI1 3.50132673580082 2.42716349086937e-15 -3.20095302741943 3.61514805440821e-17 MirTarget -0.427481623224712 8.25619928188081e-28 NA NA NA hsa-miR-200c-3p MSN 3.50132673580082 2.42716349086937e-15 -0.85546319996218 0.0136615174636227 miRNAWalker2_validate;miRTarBase;MirTarget -0.394048408331182 7.19357787283363e-31 NA NA NA hsa-miR-200c-3p MSRB3 3.50132673580082 2.42716349086937e-15 -3.32124931554379 1.17358848755899e-14 mirMAP -0.636225939222873 9.31523742862297e-54 NA NA NA hsa-miR-200c-3p MTAP 3.50132673580082 2.42716349086937e-15 -0.408994822912712 0.41815782159096 MirTarget -0.216008458217344 4.55752299665167e-05 NA NA NA hsa-miR-200c-3p MYO5A 3.50132673580082 2.42716349086937e-15 -0.274576441491861 0.311620335084615 mirMAP -0.235049265780314 1.34071002498579e-17 NA NA NA hsa-miR-200c-3p NALCN 3.50132673580082 2.42716349086937e-15 -1.70339745207592 0.000986552762067509 MirTarget -0.198470253596997 0.000282759198742808 NA NA NA hsa-miR-200c-3p NCAM1 3.50132673580082 2.42716349086937e-15 -5.46812766536887 2.35522582039703e-18 miRTarBase -0.866990545789506 1.62442785889179e-44 NA NA NA hsa-miR-200c-3p NCS1 3.50132673580082 2.42716349086937e-15 -1.7356703955299 3.35229307090603e-12 miRNATAP -0.304535657151827 1.94257399715938e-34 NA NA NA hsa-miR-200c-3p NDN 3.50132673580082 2.42716349086937e-15 -1.97097807251037 3.42025004662974e-07 MirTarget;miRNATAP -0.21963095607133 7.55469106933536e-08 NA NA NA hsa-miR-200c-3p NDST1 3.50132673580082 2.42716349086937e-15 -0.250883286824299 0.176743296307116 miRNATAP -0.121801461619426 2.14091669862434e-10 NA NA NA hsa-miR-200c-3p NEGR1 3.50132673580082 2.42716349086937e-15 -4.77810063590076 6.81978052859699e-19 miRNATAP -0.681089626504163 8.64401576200308e-36 NA NA NA hsa-miR-200c-3p NEK9 3.50132673580082 2.42716349086937e-15 -0.68505771922002 5.87748183701095e-07 MirTarget -0.101670615640732 9.27048246413276e-13 NA NA NA hsa-miR-200c-3p NFASC 3.50132673580082 2.42716349086937e-15 -2.95717922837883 4.31475260476481e-14 miRNATAP -0.304840184738999 2.10611001389752e-13 23185507 miR 200c targets a NF κB up regulated TrkB/NTF3 autocrine signaling loop to enhance anoikis sensitivity in triple negative breast cancer breast cancer hsa-miR-200c-3p NFIA 3.50132673580082 2.42716349086937e-15 -2.09936885926166 1.0458025267903e-15 MirTarget;miRNATAP -0.200285957581366 6.83765670745436e-13 NA NA NA hsa-miR-200c-3p NFIB 3.50132673580082 2.42716349086937e-15 -1.72909658442002 3.18902339154006e-09 miRNATAP -0.213084274434391 3.61043657901559e-12 NA NA NA hsa-miR-200c-3p NOG 3.50132673580082 2.42716349086937e-15 -1.04996957338848 0.0827224388167783 MirTarget;miRNATAP -0.376049889176797 2.18212060301929e-09 NA NA NA hsa-miR-200c-3p NOVA1 3.50132673580082 2.42716349086937e-15 -4.21914714578111 7.21315612695789e-16 MirTarget;miRNATAP -0.420421113341647 4.0648338601721e-14 NA NA NA hsa-miR-200c-3p NPC1 3.50132673580082 2.42716349086937e-15 -0.0845907427747106 0.656311240831085 MirTarget -0.123577565385806 3.00645786245411e-10 NA NA NA hsa-miR-200c-3p NR3C1 3.50132673580082 2.42716349086937e-15 -1.29490546417786 3.89055618845506e-05 miRNATAP -0.314248714852543 4.66913145651316e-23 NA NA NA hsa-miR-200c-3p NR5A2 3.50132673580082 2.42716349086937e-15 -1.30745675590419 3.0949312510936e-06 miRNATAP -0.120332151497725 5.22354106198246e-05 NA NA NA hsa-miR-200c-3p NRG1 3.50132673580082 2.42716349086937e-15 -1.2378190219847 0.0741741552249905 miRNATAP -0.385142513117602 1.00816945988738e-07 NA NA NA hsa-miR-200c-3p NRIP3 3.50132673580082 2.42716349086937e-15 0.266916024330568 0.374772934924586 mirMAP -0.114212099439722 0.00029942373521186 NA NA NA hsa-miR-200c-3p NTRK2 3.50132673580082 2.42716349086937e-15 -3.4444884279512 9.02401971614574e-08 miRNAWalker2_validate;miRTarBase -0.558218294130396 5.1648144515451e-17 23209748;23074172 miR 200c sensitizes breast cancer cells to doxorubicin treatment by decreasing TrkB and Bmi1 expression;miR-200c also targets TrkB a mediator of resistance to anoikis ;drug resistance breast cancer;ovarian cancer hsa-miR-200c-3p OSTM1 3.50132673580082 2.42716349086937e-15 -0.771975269003669 5.13573784724769e-06 MirTarget -0.194766497800319 2.66480355003549e-31 NA NA NA hsa-miR-200c-3p PALM2-AKAP2 3.50132673580082 2.42716349086937e-15 -1.62425751829219 3.00539592164251e-07 miRNATAP -0.423109617127978 1.14386142925674e-43 NA NA NA hsa-miR-200c-3p PAM 3.50132673580082 2.42716349086937e-15 -1.35766444679164 1.04680437362722e-07 miRNATAP -0.266951913565069 4.25654425779481e-25 NA NA NA hsa-miR-200c-3p PARD3B 3.50132673580082 2.42716349086937e-15 -2.99814829542465 1.05899403250138e-11 MirTarget;miRNATAP -0.267343590479044 1.34152057681657e-08 NA NA NA hsa-miR-200c-3p PCDH10 3.50132673580082 2.42716349086937e-15 -3.23750023602778 3.50143209305191e-07 MirTarget -0.525549846290652 1.40969347650151e-15 NA NA NA hsa-miR-200c-3p PCDH19 3.50132673580082 2.42716349086937e-15 -2.41945740586477 5.73468735015548e-07 miRNATAP -0.156524617218137 0.00246792299295543 NA NA NA hsa-miR-200c-3p PCSK2 3.50132673580082 2.42716349086937e-15 -6.63257584033356 1.5810712933526e-27 miRNATAP -0.387549940282484 1.11101205605129e-08 NA NA NA hsa-miR-200c-3p PDE4D 3.50132673580082 2.42716349086937e-15 -2.16999194209536 1.89831164898157e-16 mirMAP -0.184616201011291 6.88048055797604e-11 NA NA NA hsa-miR-200c-3p PDE5A 3.50132673580082 2.42716349086937e-15 -2.72242827068326 2.90742264752214e-19 miRNATAP -0.300696725838192 4.90943616505544e-21 NA NA NA hsa-miR-186-5p PDPK1 1.47445398888668 3.0781726595413e-15 -0.446682027133002 0.00835125010618968 mirMAP -0.125708876159213 0.00333632806915964 NA NA NA hsa-miR-22-5p PDPK1 1.88011544159252 1.63978222572222e-16 -0.446682027133002 0.00835125010618968 miRNATAP -0.181020438712566 1.45237356289081e-07 NA NA NA hsa-miR-29b-3p PDPK1 1.65828197923813 1.02676780888141e-09 -0.446682027133002 0.00835125010618968 mirMAP -0.109518325633884 0.000211964623360266 NA NA NA hsa-miR-342-3p PDPK1 1.49115144672245 1.43879249744621e-07 -0.446682027133002 0.00835125010618968 mirMAP -0.109793629457974 0.000113758361154384 NA NA NA hsa-miR-374a-3p PDPK1 0.533309330504947 0.00192918429705142 -0.446682027133002 0.00835125010618968 mirMAP -0.118308754113252 0.0142261349514195 NA NA NA hsa-miR-200c-3p PEG10 3.50132673580082 2.42716349086937e-15 -1.94098497488928 0.00571305721030311 mirMAP -0.229152283070274 0.00203538645560581 NA NA NA hsa-miR-326 PGF 0.715313016136042 0.0610265683213359 0.82580882918736 0.0169544692696931 mirMAP -0.162219493325868 0.000221458535925083 NA NA NA hsa-miR-421 PGF 1.17791565395543 6.78526676976629e-06 0.82580882918736 0.0169544692696931 miRanda -0.141102218221589 0.0272665155908835 NA NA NA hsa-miR-200c-3p PHLDB1 3.50132673580082 2.42716349086937e-15 -0.688909556015726 0.00122355801941463 MirTarget;miRNATAP -0.192312421062445 6.25242384626231e-19 NA NA NA hsa-miR-126-5p PIK3CA 0.895338176458417 2.33372756450713e-05 -0.151828236462886 0.321284398928338 mirMAP -0.103377544898631 0.00298975306098663 NA NA NA hsa-miR-186-5p PIK3CA 1.47445398888668 3.0781726595413e-15 -0.151828236462886 0.321284398928338 mirMAP -0.101671973753504 0.00842161241015832 NA NA NA hsa-miR-320a PIK3CA 0.438165828017084 0.0390159073347133 -0.151828236462886 0.321284398928338 miRanda -0.153857910084833 9.6763748473785e-06 NA NA NA hsa-miR-10b-5p PIK3CD -0.155951595811628 0.555006386998027 -0.775351667927902 0.021645534884375 miRNAWalker2_validate -0.175760207889201 0.004748835358114 NA NA NA hsa-miR-1468-5p PIK3CD 0.0469536064343461 0.881810795145912 -0.775351667927902 0.021645534884375 MirTarget -0.223784917601258 1.49208556354691e-05 NA NA NA hsa-miR-29c-3p PIK3CD -0.00968972577705429 0.97099586346872 -0.775351667927902 0.021645534884375 mirMAP -0.250794863940076 4.41169066967662e-05 NA NA NA hsa-miR-30b-3p PIK3CD 0.834142820354026 0.000972582820878813 -0.775351667927902 0.021645534884375 MirTarget -0.531045557079738 2.22640594160628e-17 NA NA NA hsa-miR-30b-5p PIK3CD 0.800822374912712 0.000133601914525413 -0.775351667927902 0.021645534884375 MirTarget -0.411457344396036 9.99002635635066e-08 NA NA NA hsa-miR-30c-5p PIK3CD 0.778774633108 0.000285599212429136 -0.775351667927902 0.021645534884375 MirTarget;miRNATAP -0.461850084291099 7.5210996634642e-10 NA NA NA hsa-miR-30d-5p PIK3CD 0.675423997639582 0.00270618816039773 -0.775351667927902 0.021645534884375 MirTarget;miRNATAP -0.733785480070449 9.30689014359708e-27 NA NA NA hsa-miR-30e-5p PIK3CD 1.23904909539663 1.35561917122157e-09 -0.775351667927902 0.021645534884375 MirTarget -0.597650735147178 7.00788139486401e-15 NA NA NA hsa-miR-320a PIK3CD 0.438165828017084 0.0390159073347133 -0.775351667927902 0.021645534884375 miRanda -0.437629854617933 1.07773535518864e-08 NA NA NA hsa-miR-320b PIK3CD 1.55692969039548 1.41071034251915e-08 -0.775351667927902 0.021645534884375 miRanda -0.282783919094812 1.19379715607107e-06 NA NA NA hsa-miR-324-5p PIK3CD 2.95683728155095 1.32960514360912e-20 -0.775351667927902 0.021645534884375 miRanda -0.265511883710764 4.30342749668002e-08 NA NA NA hsa-miR-3913-5p PIK3CD 2.44353493655328 8.95279496632448e-15 -0.775351667927902 0.021645534884375 mirMAP -0.395313104822511 3.24743386923115e-15 NA NA NA hsa-miR-421 PIK3CD 1.17791565395543 6.78526676976629e-06 -0.775351667927902 0.021645534884375 miRanda -0.235490163150307 0.000146542275873157 NA NA NA hsa-miR-484 PIK3CD 1.81844463411787 1.82951571230938e-15 -0.775351667927902 0.021645534884375 MirTarget;miRNATAP -0.387158078139352 1.61214627982237e-08 NA NA NA hsa-miR-148b-3p PIK3CG 1.97815018171325 6.07715327281595e-26 -1.04493260087656 0.00941484120426313 miRNAWalker2_validate -0.598035215538084 7.05982657783629e-10 NA NA NA hsa-miR-26b-5p PIK3CG 0.885393662798425 3.2116297961629e-06 -1.04493260087656 0.00941484120426313 miRNAWalker2_validate -0.252635166842034 0.0140326902426817 NA NA NA hsa-miR-335-3p PIK3CG 3.08791651139852 5.31309869723517e-12 -1.04493260087656 0.00941484120426313 mirMAP -0.182751911295676 1.44284270796844e-05 NA NA NA hsa-miR-3607-3p PIK3CG 2.68532138541128 5.66716351955047e-14 -1.04493260087656 0.00941484120426313 mirMAP -0.166734433414221 0.00216182223501734 NA NA NA hsa-miR-421 PIK3CG 1.17791565395543 6.78526676976629e-06 -1.04493260087656 0.00941484120426313 miRanda -0.208294811185602 0.00505346682917229 NA NA NA hsa-miR-590-3p PIK3CG 2.59289455139753 1.03200520972022e-21 -1.04493260087656 0.00941484120426313 miRanda -0.160421801003692 0.0232620908281926 NA NA NA hsa-miR-101-5p PIK3R1 0.782067874775122 0.00443725251526842 -1.16357283690918 1.63774086027679e-06 MirTarget -0.115568250605295 0.00948870207662742 NA NA NA hsa-miR-103a-3p PIK3R1 1.44083190496858 1.53799939616416e-13 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.175702483843164 0.00322284399016944 NA NA NA hsa-miR-106b-5p PIK3R1 2.46782146831112 1.36171495805632e-23 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.24930934707311 3.35624085651532e-08 NA NA NA hsa-miR-107 PIK3R1 1.30977326593435 1.30372468603965e-11 -1.16357283690918 1.63774086027679e-06 MirTarget;PITA;miRanda;miRNATAP -0.201353514049413 0.000854368494298006 NA NA NA hsa-miR-127-5p PIK3R1 1.19850695520181 4.10976607177645e-05 -1.16357283690918 1.63774086027679e-06 MirTarget;PITA;miRNATAP -0.164276045731973 4.35688271416755e-05 24004856 Integrated gene network analysis and text mining revealing PIK3R1 regulated by miR 127 in human bladder cancer; These findings provide new insights into the role of miRNAs in the pathway of cancer and give us a hypothesis that miR-127 might play a similar role in regulation and control of PIK3R1 bladder cancer hsa-miR-128-3p PIK3R1 1.63756041666078 6.79626586407187e-14 -1.16357283690918 1.63774086027679e-06 MirTarget -0.134770050316621 0.0111594593028352 25962360 miR 128 3p suppresses hepatocellular carcinoma proliferation by regulating PIK3R1 and is correlated with the prognosis of HCC patients; Mechanistically miR-128-3p was confirmed to regulate PIK3R1 p85α expression thereby suppressing phosphatidylinositol 3-kinase PI3K/AKT pathway activation using qRT-PCR and western blot analysis; Hence we conclude that miR-128-3p which is frequently downregulated in HCC inhibits HCC progression by regulating PIK3R1 and PI3K/AKT activation and is a prognostic marker for HCC patients worse prognosis;progression liver cancer hsa-miR-1301-3p PIK3R1 2.54959518791507 5.26618591274892e-18 -1.16357283690918 1.63774086027679e-06 MirTarget -0.146009716288673 0.000153002833756534 NA NA NA hsa-miR-132-3p PIK3R1 0.156276992635384 0.408190812100704 -1.16357283690918 1.63774086027679e-06 MirTarget -0.197496588157407 0.00191277589406782 NA NA NA hsa-miR-15a-5p PIK3R1 2.34669284378787 1.69544424500258e-23 -1.16357283690918 1.63774086027679e-06 MirTarget -0.142181030175195 0.00308171212654804 NA NA NA hsa-miR-15b-5p PIK3R1 1.57112623124278 9.14247846750597e-13 -1.16357283690918 1.63774086027679e-06 MirTarget -0.203388250610072 0.000112366544945594 NA NA NA hsa-miR-16-2-3p PIK3R1 2.31623086727196 4.29838149388188e-20 -1.16357283690918 1.63774086027679e-06 MirTarget -0.207543782293348 3.49270114018875e-06 NA NA NA hsa-miR-16-5p PIK3R1 1.75824877145857 1.68592440033108e-16 -1.16357283690918 1.63774086027679e-06 MirTarget -0.20266090985161 0.000166722510489398 NA NA NA hsa-miR-17-5p PIK3R1 3.2710598467455 9.93128340539455e-27 -1.16357283690918 1.63774086027679e-06 MirTarget;TargetScan;miRNATAP -0.194269031204595 7.03363082546611e-08 NA NA NA hsa-miR-185-5p PIK3R1 2.34016206907488 1.17481626642022e-26 -1.16357283690918 1.63774086027679e-06 miRNATAP -0.305558512858305 1.29388513669652e-09 NA NA NA hsa-miR-186-5p PIK3R1 1.47445398888668 3.0781726595413e-15 -1.16357283690918 1.63774086027679e-06 mirMAP -0.274872917366815 8.27585129634137e-06 NA NA NA hsa-miR-188-5p PIK3R1 2.52825126596644 6.78099435999778e-14 -1.16357283690918 1.63774086027679e-06 MirTarget -0.185661747772095 2.50402606338374e-07 NA NA NA hsa-miR-199a-3p PIK3R1 0.640600337515787 0.0380326905134914 -1.16357283690918 1.63774086027679e-06 miRNATAP -0.156998919927599 4.11373421997523e-05 NA NA NA hsa-miR-199b-3p PIK3R1 0.643923492750702 0.0371742251925406 -1.16357283690918 1.63774086027679e-06 miRNATAP -0.157124307871095 4.00275047495595e-05 NA NA NA hsa-miR-20a-5p PIK3R1 3.15577933619191 4.19753346442454e-25 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.184775072209508 3.70396511881761e-07 NA NA NA hsa-miR-21-5p PIK3R1 2.73773305747971 1.38864982139576e-43 -1.16357283690918 1.63774086027679e-06 miRNAWalker2_validate;MirTarget;miRNATAP -0.344443286817705 1.08270725892964e-10 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-212-3p PIK3R1 0.357878936470387 0.232446214501331 -1.16357283690918 1.63774086027679e-06 MirTarget -0.126995222417611 0.00147059810557586 NA NA NA hsa-miR-22-5p PIK3R1 1.88011544159252 1.63978222572222e-16 -1.16357283690918 1.63774086027679e-06 mirMAP -0.292552038138818 3.89552165607854e-09 NA NA NA hsa-miR-221-3p PIK3R1 0.451556679024397 0.0909808299917811 -1.16357283690918 1.63774086027679e-06 MirTarget -0.108240747635063 0.015387314456947 NA NA NA hsa-miR-222-3p PIK3R1 0.851783756239071 0.00266783568486918 -1.16357283690918 1.63774086027679e-06 MirTarget -0.122260306324505 0.00346350093932025 NA NA NA hsa-miR-29a-3p PIK3R1 -0.35074463683376 0.161238718982428 -1.16357283690918 1.63774086027679e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.197768036084372 3.04095884680599e-05 NA NA NA hsa-miR-29b-3p PIK3R1 1.65828197923813 1.02676780888141e-09 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.226570180742736 9.59427672061032e-08 NA NA NA hsa-miR-3065-5p PIK3R1 2.74629919868982 1.86846589298284e-08 -1.16357283690918 1.63774086027679e-06 MirTarget;mirMAP;miRNATAP -0.121456370441073 3.04699134862982e-05 NA NA NA hsa-miR-369-3p PIK3R1 0.946781510019564 0.00134850306966842 -1.16357283690918 1.63774086027679e-06 PITA -0.165045838001649 3.68847028364345e-05 NA NA NA hsa-miR-409-3p PIK3R1 0.877551657794358 0.00171210686733898 -1.16357283690918 1.63774086027679e-06 mirMAP -0.105859697586648 0.0126015776971144 NA NA NA hsa-miR-424-5p PIK3R1 1.61930224569578 1.89642549274994e-10 -1.16357283690918 1.63774086027679e-06 MirTarget -0.203727044936863 7.79524954848401e-06 NA NA NA hsa-miR-450b-5p PIK3R1 1.69244418548325 1.68064054148881e-10 -1.16357283690918 1.63774086027679e-06 miRNATAP -0.119371689321084 0.0066882062526509 NA NA NA hsa-miR-455-3p PIK3R1 3.06093594997644 3.54590649799868e-16 -1.16357283690918 1.63774086027679e-06 MirTarget;PITA;miRNATAP -0.151223028806072 5.34851043578223e-07 NA NA NA hsa-miR-485-3p PIK3R1 0.442820096243914 0.166634696770945 -1.16357283690918 1.63774086027679e-06 mirMAP -0.104228852223792 0.00542492277409986 NA NA NA hsa-miR-493-5p PIK3R1 0.847772103665986 0.00528678068747754 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.141629319654 0.000286613564823519 NA NA NA hsa-miR-532-3p PIK3R1 1.96631878320218 4.53421954361695e-13 -1.16357283690918 1.63774086027679e-06 MirTarget -0.183574493282594 1.45132602336302e-05 NA NA NA hsa-miR-584-5p PIK3R1 2.7326672683732 9.92677936962233e-12 -1.16357283690918 1.63774086027679e-06 mirMAP -0.136506526285572 1.76178566940588e-06 NA NA NA hsa-miR-589-3p PIK3R1 2.51971841868825 2.39125940264107e-11 -1.16357283690918 1.63774086027679e-06 mirMAP -0.146863008859422 2.43953052082368e-05 NA NA NA hsa-miR-590-3p PIK3R1 2.59289455139753 1.03200520972022e-21 -1.16357283690918 1.63774086027679e-06 miRanda;mirMAP -0.251414695908109 2.6774008322444e-09 NA NA NA hsa-miR-590-5p PIK3R1 3.18300989862077 2.06813568597893e-26 -1.16357283690918 1.63774086027679e-06 MirTarget;PITA;miRanda;miRNATAP -0.233958943001206 5.13569363038349e-10 NA NA NA hsa-miR-629-3p PIK3R1 2.36570947321815 1.33458201201618e-11 -1.16357283690918 1.63774086027679e-06 MirTarget -0.157530213698435 2.37486100403133e-05 NA NA NA hsa-miR-93-5p PIK3R1 3.03961860136032 1.11672209617395e-24 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.155676924698248 3.5347453293642e-05 NA NA NA hsa-miR-96-5p PIK3R1 4.89433085814374 1.92000659886961e-31 -1.16357283690918 1.63774086027679e-06 TargetScan;miRNATAP -0.102966561567807 0.000122371084822612 NA NA NA hsa-miR-1271-5p PIK3R3 0.970418832993172 0.000609742584380688 -0.627704444396048 0.00578594022892978 mirMAP -0.151257171385516 9.56593049733625e-05 NA NA NA hsa-miR-181a-5p PIK3R3 2.29556023480783 1.8138457900616e-21 -0.627704444396048 0.00578594022892978 MirTarget;miRNATAP -0.108906602043709 0.0127134423930606 NA NA NA hsa-miR-18a-3p PIK3R3 2.14813400940323 2.23460809936028e-06 -0.627704444396048 0.00578594022892978 miRNAWalker2_validate -0.10342220794232 0.000634896497880219 NA NA NA hsa-miR-19a-3p PIK3R3 3.42309334186656 3.02671914353412e-28 -0.627704444396048 0.00578594022892978 MirTarget;miRNATAP -0.120784849374387 0.0002630092907536 NA NA NA hsa-miR-19b-3p PIK3R3 2.49529833021187 1.57028265846699e-23 -0.627704444396048 0.00578594022892978 MirTarget;miRNATAP -0.146052627292238 0.000482454548266062 NA NA NA hsa-miR-222-5p PIK3R3 1.25632771414778 0.000138653440511922 -0.627704444396048 0.00578594022892978 mirMAP -0.146201383530692 9.47483044017924e-06 NA NA NA hsa-miR-26b-5p PIK3R3 0.885393662798425 3.2116297961629e-06 -0.627704444396048 0.00578594022892978 miRNATAP -0.184498425433638 0.00145436639404193 NA NA NA hsa-miR-29b-1-5p PIK3R3 1.55384379072167 4.76870585070176e-05 -0.627704444396048 0.00578594022892978 mirMAP -0.182944374912975 8.7655907053222e-10 NA NA NA hsa-miR-365a-3p PIK3R3 -0.0388985816963467 0.859114494267351 -0.627704444396048 0.00578594022892978 MirTarget -0.222976439335601 9.85809729911043e-06 NA NA NA hsa-miR-511-5p PIK3R3 1.04499312543772 0.00234126154508174 -0.627704444396048 0.00578594022892978 MirTarget -0.132527709680848 3.18921565069019e-05 25608840 MiR 511 inhibits growth and metastasis of human hepatocellular carcinoma cells by targeting PIK3R3; We further demonstrated that miR-511 suppressed HCC cell proliferation migration and invasion by repressing PIK3R3 expression metastasis liver cancer hsa-miR-92a-3p PIK3R3 2.06460102658973 1.44784291084757e-19 -0.627704444396048 0.00578594022892978 MirTarget;miRNATAP -0.185970971603602 5.73870254874264e-05 NA NA NA hsa-miR-107 PIK3R5 1.30977326593435 1.30372468603965e-11 -0.990769658200862 0.00792713202187119 miRanda -0.533513362792699 4.18278914923372e-09 NA NA NA hsa-miR-125a-3p PIK3R5 1.24490295132072 5.26925231010328e-06 -0.990769658200862 0.00792713202187119 miRanda -0.135508023882326 0.0399369211652034 NA NA NA hsa-miR-125a-5p PIK3R5 0.599529391575274 0.0102300147180307 -0.990769658200862 0.00792713202187119 MirTarget;miRanda -0.398754902125041 2.22481895610409e-07 NA NA NA hsa-miR-182-5p PIK3R5 3.53923166221814 5.07781258121574e-21 -0.990769658200862 0.00792713202187119 MirTarget -0.391730270801049 4.50362857100536e-19 NA NA NA hsa-miR-185-5p PIK3R5 2.34016206907488 1.17481626642022e-26 -0.990769658200862 0.00792713202187119 MirTarget -0.277336834855249 0.000367374066791577 NA NA NA hsa-miR-18a-3p PIK3R5 2.14813400940323 2.23460809936028e-06 -0.990769658200862 0.00792713202187119 MirTarget -0.132688083528877 0.0077571943603639 NA NA NA hsa-miR-330-5p PIK3R5 1.15100069700871 4.85551805046014e-07 -0.990769658200862 0.00792713202187119 MirTarget;miRanda -0.220865262481851 0.00496435762424894 NA NA NA hsa-miR-944 PIK3R5 2.91186649218281 1.31574753528144e-06 -0.990769658200862 0.00792713202187119 mirMAP -0.201291119960673 1.82909637448261e-11 NA NA NA hsa-miR-200c-3p PLCL1 3.50132673580082 2.42716349086937e-15 -2.35657424868599 1.25135556692163e-13 MirTarget -0.408828817205366 2.17160107267565e-38 NA NA NA hsa-miR-200c-3p PLK2 3.50132673580082 2.42716349086937e-15 -0.184734083567005 0.553818611811747 miRNATAP -0.153685938478197 2.41030637915006e-06 NA NA NA hsa-miR-200c-3p PLXNA4 3.50132673580082 2.42716349086937e-15 -2.25456361904941 4.96438419774251e-05 miRNATAP -0.679926341659152 5.4086890819909e-36 NA NA NA hsa-miR-200c-3p PLXNC1 3.50132673580082 2.42716349086937e-15 -0.532339572840622 0.284697523094741 miRNATAP -0.428294069530617 2.38986484144414e-17 NA NA NA hsa-miR-200c-3p PPARGC1A 3.50132673580082 2.42716349086937e-15 -4.12246484079635 1.21340396096287e-10 mirMAP -0.483417114278318 7.39173001877038e-13 NA NA NA hsa-miR-200c-3p PPM1F 3.50132673580082 2.42716349086937e-15 -0.484267586694392 0.00139346420727647 miRNAWalker2_validate;MirTarget;miRNATAP -0.133273390159974 4.78555485126521e-18 22144583 MicroRNA 200c represses migration and invasion of breast cancer cells by targeting actin regulatory proteins FHOD1 and PPM1F; We identified FHOD1 and PPM1F direct regulators of the actin cytoskeleton as novel targets of miR-200c; Remarkably expression levels of FHOD1 and PPM1F were inversely correlated with the level of miR-200c in breast cancer cell lines breast cancer patient samples and 58 cancer cell lines of various origins breast cancer hsa-miR-200c-3p PPP2R2C 3.50132673580082 2.42716349086937e-15 -0.795459846555288 0.266159255773917 miRNATAP -0.306291787073106 4.49365552911052e-05 NA NA NA hsa-miR-200c-3p PRDM1 3.50132673580082 2.42716349086937e-15 -0.799773282697487 0.0106840144209139 miRNATAP -0.101768221707449 0.00210189024339143 NA NA NA hsa-miR-200c-3p PRDM16 3.50132673580082 2.42716349086937e-15 -2.56004666228196 1.1360029849919e-06 MirTarget;miRNATAP -0.298506679024547 7.59595353156344e-08 NA NA NA hsa-let-7a-3p PRKAA2 1.42015538786275 7.03375209382654e-13 -3.1651157275578 4.06046613880045e-09 mirMAP -0.368546290584595 0.00514409913387135 NA NA NA hsa-let-7b-3p PRKAA2 0.868207752019623 1.30460056774366e-05 -3.1651157275578 4.06046613880045e-09 mirMAP -0.262674016711226 0.0494116538292108 NA NA NA hsa-let-7d-5p PRKAA2 1.33236798905207 1.1741085658466e-13 -3.1651157275578 4.06046613880045e-09 MirTarget -0.722750408548456 4.99138878435736e-07 NA NA NA hsa-let-7f-1-3p PRKAA2 1.55054488387679 7.31326775537952e-11 -3.1651157275578 4.06046613880045e-09 mirMAP -0.46638995733722 3.18954726371122e-05 NA NA NA hsa-let-7f-5p PRKAA2 0.495648727272215 0.00355972741198794 -3.1651157275578 4.06046613880045e-09 MirTarget -0.311815532548627 0.0490723533883445 NA NA NA hsa-let-7g-5p PRKAA2 1.20061455355116 1.50237505511483e-12 -3.1651157275578 4.06046613880045e-09 MirTarget -0.829014454032662 5.47891741707445e-08 NA NA NA hsa-let-7i-5p PRKAA2 0.412877696970403 0.00622731051981756 -3.1651157275578 4.06046613880045e-09 MirTarget -0.607502181924338 0.000681606877218508 NA NA NA hsa-miR-103a-2-5p PRKAA2 2.47599305985086 7.933028987326e-11 -3.1651157275578 4.06046613880045e-09 mirMAP -0.273304170202619 0.000379680069074106 NA NA NA hsa-miR-106b-5p PRKAA2 2.46782146831112 1.36171495805632e-23 -3.1651157275578 4.06046613880045e-09 mirMAP -0.449758621112524 9.45695175297387e-06 NA NA NA hsa-miR-125a-5p PRKAA2 0.599529391575274 0.0102300147180307 -3.1651157275578 4.06046613880045e-09 PITA -0.365087293868699 0.00135901058962619 NA NA NA hsa-miR-126-5p PRKAA2 0.895338176458417 2.33372756450713e-05 -3.1651157275578 4.06046613880045e-09 mirMAP -0.499415855416577 6.2491772215473e-05 NA NA NA hsa-miR-130b-3p PRKAA2 3.5350292994509 1.73934183852569e-27 -3.1651157275578 4.06046613880045e-09 MirTarget -0.30993060839259 4.53844629194696e-05 NA NA NA hsa-miR-141-3p PRKAA2 5.02396127982626 2.19224509139725e-24 -3.1651157275578 4.06046613880045e-09 mirMAP -0.311674641790567 3.76173236669185e-10 NA NA NA hsa-miR-142-5p PRKAA2 1.17581605694506 0.0018174701991234 -3.1651157275578 4.06046613880045e-09 mirMAP -0.307256732153854 1.00914367535293e-05 NA NA NA hsa-miR-146a-5p PRKAA2 1.19829319599115 0.00157081974524452 -3.1651157275578 4.06046613880045e-09 MirTarget -0.298359820970352 1.6416322978257e-05 NA NA NA hsa-miR-146b-5p PRKAA2 1.75587235896724 1.15724631266659e-07 -3.1651157275578 4.06046613880045e-09 MirTarget -0.311641849597315 7.38240690301751e-05 NA NA NA hsa-miR-15b-3p PRKAA2 2.33847028227712 4.29662877950836e-19 -3.1651157275578 4.06046613880045e-09 mirMAP -0.477684703528837 7.08126425805273e-07 NA NA NA hsa-miR-16-2-3p PRKAA2 2.31623086727196 4.29838149388188e-20 -3.1651157275578 4.06046613880045e-09 mirMAP -0.627940578646649 2.13766832392934e-10 NA NA NA hsa-miR-17-5p PRKAA2 3.2710598467455 9.93128340539455e-27 -3.1651157275578 4.06046613880045e-09 mirMAP -0.365611825057462 6.28601305540822e-06 NA NA NA hsa-miR-181a-2-3p PRKAA2 2.19062681262366 3.81790102612782e-13 -3.1651157275578 4.06046613880045e-09 mirMAP -0.446762077174767 1.28755345125413e-07 NA NA NA hsa-miR-181a-5p PRKAA2 2.29556023480783 1.8138457900616e-21 -3.1651157275578 4.06046613880045e-09 mirMAP -0.652763486781636 2.45814293770857e-10 NA NA NA hsa-miR-181b-5p PRKAA2 2.49307679431293 3.92829250217627e-20 -3.1651157275578 4.06046613880045e-09 mirMAP -0.553820083358037 1.79038809431955e-09 NA NA NA hsa-miR-182-5p PRKAA2 3.53923166221814 5.07781258121574e-21 -3.1651157275578 4.06046613880045e-09 miRNAWalker2_validate;MirTarget;mirMAP -0.331706760870251 5.94483360132956e-07 NA NA NA hsa-miR-186-5p PRKAA2 1.47445398888668 3.0781726595413e-15 -3.1651157275578 4.06046613880045e-09 MirTarget -0.526806950486461 0.000138268992490229 NA NA NA hsa-miR-192-5p PRKAA2 2.69002528723195 1.22990188194432e-16 -3.1651157275578 4.06046613880045e-09 miRNAWalker2_validate -0.161378715666907 0.0407539432354523 NA NA NA hsa-miR-19a-3p PRKAA2 3.42309334186656 3.02671914353412e-28 -3.1651157275578 4.06046613880045e-09 mirMAP -0.379428611341206 1.66931323472125e-06 NA NA NA hsa-miR-19b-3p PRKAA2 2.49529833021187 1.57028265846699e-23 -3.1651157275578 4.06046613880045e-09 mirMAP -0.447494148517396 8.06927629243583e-06 NA NA NA hsa-miR-200a-3p PRKAA2 4.59434485520731 6.38952518573476e-18 -3.1651157275578 4.06046613880045e-09 mirMAP -0.252415609716866 8.38336062600942e-08 NA NA NA hsa-miR-200b-3p PRKAA2 3.78235093249346 3.18343003239465e-14 -3.1651157275578 4.06046613880045e-09 MirTarget -0.261801092835381 2.7256487514151e-07 NA NA NA hsa-miR-200c-3p PRKAA2 3.50132673580082 2.42716349086937e-15 -3.1651157275578 4.06046613880045e-09 MirTarget -0.3165574137351 2.9537182424848e-08 NA NA NA hsa-miR-203a-3p PRKAA2 3.12352008343999 9.49391438647189e-07 -3.1651157275578 4.06046613880045e-09 MirTarget -0.114021445045374 0.00543014379350566 NA NA NA hsa-miR-20a-5p PRKAA2 3.15577933619191 4.19753346442454e-25 -3.1651157275578 4.06046613880045e-09 mirMAP -0.371335239957246 5.16233816597501e-06 NA NA NA hsa-miR-21-3p PRKAA2 2.19296355304364 4.63665722759779e-15 -3.1651157275578 4.06046613880045e-09 mirMAP -0.424686931257561 3.18678833497258e-06 NA NA NA hsa-miR-22-5p PRKAA2 1.88011544159252 1.63978222572222e-16 -3.1651157275578 4.06046613880045e-09 mirMAP -0.640613793079929 8.15181736251034e-09 NA NA NA hsa-miR-23a-3p PRKAA2 1.00493340843378 2.55313889288924e-08 -3.1651157275578 4.06046613880045e-09 mirMAP -0.717245625409375 7.83285299814301e-07 NA NA NA hsa-miR-26a-2-3p PRKAA2 0.823520019989974 0.00017092160823769 -3.1651157275578 4.06046613880045e-09 mirMAP -0.408717713181205 0.000788807753650383 NA NA NA hsa-miR-26a-5p PRKAA2 0.0464832722967259 0.752628386912329 -3.1651157275578 4.06046613880045e-09 mirMAP -0.397860835240243 0.0313650980967207 NA NA NA hsa-miR-26b-5p PRKAA2 0.885393662798425 3.2116297961629e-06 -3.1651157275578 4.06046613880045e-09 mirMAP -0.764962785810813 2.83597630191631e-08 NA NA NA hsa-miR-27b-5p PRKAA2 0.393316367667332 0.051702301924024 -3.1651157275578 4.06046613880045e-09 MirTarget;miRNATAP -0.383639737600614 0.0037825291986155 NA NA NA hsa-miR-29b-2-5p PRKAA2 0.910668640983475 0.00666655585493488 -3.1651157275578 4.06046613880045e-09 mirMAP -0.279808749959182 0.00038252900575232 NA NA NA hsa-miR-301a-3p PRKAA2 2.81024345929638 2.29784847962242e-17 -3.1651157275578 4.06046613880045e-09 MirTarget -0.231119799911066 0.0045176787682093 NA NA NA hsa-miR-30b-5p PRKAA2 0.800822374912712 0.000133601914525413 -3.1651157275578 4.06046613880045e-09 MirTarget -0.288057119153475 0.0233572155059335 NA NA NA hsa-miR-30c-5p PRKAA2 0.778774633108 0.000285599212429136 -3.1651157275578 4.06046613880045e-09 MirTarget -0.356922096763827 0.00395922355020181 NA NA NA hsa-miR-30d-3p PRKAA2 0.977747550180601 4.3048212205381e-05 -3.1651157275578 4.06046613880045e-09 MirTarget;miRNATAP -0.240071186464927 0.0307082267542837 NA NA NA hsa-miR-30d-5p PRKAA2 0.675423997639582 0.00270618816039773 -3.1651157275578 4.06046613880045e-09 MirTarget -0.271897797341097 0.0216937703176945 NA NA NA hsa-miR-30e-5p PRKAA2 1.23904909539663 1.35561917122157e-09 -3.1651157275578 4.06046613880045e-09 MirTarget -0.575531898888406 6.37486734638196e-06 NA NA NA hsa-miR-31-5p PRKAA2 3.59165123035072 2.27423212057482e-07 -3.1651157275578 4.06046613880045e-09 MirTarget -0.151730039535611 0.000135936484549104 NA NA NA hsa-miR-32-3p PRKAA2 2.02436999565685 5.94091197945307e-09 -3.1651157275578 4.06046613880045e-09 MirTarget -0.205177944089292 0.0165918636397811 NA NA NA hsa-miR-330-3p PRKAA2 0.876747334239085 0.00073709016089703 -3.1651157275578 4.06046613880045e-09 MirTarget -0.286102780581204 0.00506815071493037 NA NA NA hsa-miR-331-3p PRKAA2 2.28379581858927 1.99663919173155e-18 -3.1651157275578 4.06046613880045e-09 MirTarget -0.364561950555569 0.000185201672784168 NA NA NA hsa-miR-335-3p PRKAA2 3.08791651139852 5.31309869723517e-12 -3.1651157275578 4.06046613880045e-09 MirTarget -0.217607069917347 0.000151452265177902 NA NA NA hsa-miR-335-5p PRKAA2 1.77247705492746 2.22457658872091e-06 -3.1651157275578 4.06046613880045e-09 MirTarget;miRNATAP -0.189757321047362 0.00673896582128403 NA NA NA hsa-miR-33a-3p PRKAA2 1.72765312072219 1.51784443453521e-07 -3.1651157275578 4.06046613880045e-09 mirMAP -0.197716151311991 0.0240888641750769 NA NA NA hsa-miR-342-3p PRKAA2 1.49115144672245 1.43879249744621e-07 -3.1651157275578 4.06046613880045e-09 PITA -0.365301673219482 7.27987168209179e-05 NA NA NA hsa-miR-34a-5p PRKAA2 1.9016323452565 1.43092834643601e-14 -3.1651157275578 4.06046613880045e-09 miRNATAP -0.697992393841294 7.93258270698692e-12 NA NA NA hsa-miR-374a-3p PRKAA2 0.533309330504947 0.00192918429705142 -3.1651157275578 4.06046613880045e-09 mirMAP -0.468265324710388 0.0026860278599259 NA NA NA hsa-miR-429 PRKAA2 4.48815175680773 2.44117492218206e-17 -3.1651157275578 4.06046613880045e-09 MirTarget;miRNATAP -0.234368381119893 8.26598458529829e-07 NA NA NA hsa-miR-454-3p PRKAA2 2.47234127820054 1.12878018736016e-21 -3.1651157275578 4.06046613880045e-09 MirTarget -0.516124002344748 2.14118798191959e-07 NA NA NA hsa-miR-500a-5p PRKAA2 1.72110365584658 3.0807246212659e-10 -3.1651157275578 4.06046613880045e-09 mirMAP -0.291639409971857 0.00221883780805263 NA NA NA hsa-miR-576-5p PRKAA2 2.20467023993664 3.4053475193793e-19 -3.1651157275578 4.06046613880045e-09 mirMAP -0.576206223473929 1.6711936398277e-08 NA NA NA hsa-miR-582-5p PRKAA2 0.609226359812689 0.032988717891497 -3.1651157275578 4.06046613880045e-09 mirMAP -0.270459108094453 0.00363606827304358 NA NA NA hsa-miR-589-5p PRKAA2 1.71990116752371 8.310889042056e-14 -3.1651157275578 4.06046613880045e-09 MirTarget -0.376078241087496 0.00080032835281227 NA NA NA hsa-miR-590-3p PRKAA2 2.59289455139753 1.03200520972022e-21 -3.1651157275578 4.06046613880045e-09 mirMAP;miRNATAP -0.430999919941564 6.04499840743536e-06 NA NA NA hsa-miR-664a-3p PRKAA2 0.634721925861133 0.00520070178640421 -3.1651157275578 4.06046613880045e-09 MirTarget -0.510084786462165 1.19979296115228e-05 NA NA NA hsa-miR-7-1-3p PRKAA2 1.84950311431067 1.25300363397654e-13 -3.1651157275578 4.06046613880045e-09 MirTarget;mirMAP -0.360511833799086 0.000488208563484811 NA NA NA hsa-miR-93-5p PRKAA2 3.03961860136032 1.11672209617395e-24 -3.1651157275578 4.06046613880045e-09 mirMAP -0.360317996321163 1.81157969199634e-05 NA NA NA hsa-miR-944 PRKAA2 2.91186649218281 1.31574753528144e-06 -3.1651157275578 4.06046613880045e-09 mirMAP -0.304599294327695 3.71005202161829e-12 NA NA NA hsa-miR-96-5p PRKAA2 4.89433085814374 1.92000659886961e-31 -3.1651157275578 4.06046613880045e-09 TargetScan -0.301126902372243 4.20848274807667e-07 NA NA NA hsa-miR-98-5p PRKAA2 1.11154309866014 1.24143909012085e-08 -3.1651157275578 4.06046613880045e-09 miRNAWalker2_validate;MirTarget -0.364025165304353 0.00705071490635534 NA NA NA hsa-miR-200c-3p PRKACB 3.50132673580082 2.42716349086937e-15 -1.11910356116881 7.24897707751757e-07 MirTarget;miRNATAP -0.125201076382777 1.50017445380767e-07 NA NA NA hsa-miR-200c-3p PRKAR2B 3.50132673580082 2.42716349086937e-15 -2.6424142214808 7.30155345842383e-13 miRNATAP -0.267488379876048 7.71967366135021e-12 NA NA NA hsa-miR-200c-3p PRKCA 3.50132673580082 2.42716349086937e-15 -1.04253532292201 0.000330447904822586 miRNATAP -0.158977004957444 1.80034178057763e-07 NA NA NA hsa-miR-200c-3p PRKCB 3.50132673580082 2.42716349086937e-15 -3.26032077132529 1.38524824909011e-12 MirTarget;miRNATAP -0.48715771688849 5.01263551249731e-25 NA NA NA hsa-miR-200c-3p PRKG1 3.50132673580082 2.42716349086937e-15 -3.08984703833363 4.55204333556294e-10 miRNATAP -0.562636021923416 1.62782418772395e-29 NA NA NA hsa-miR-200c-3p PRLR 3.50132673580082 2.42716349086937e-15 -0.790590749858476 0.188888563043757 mirMAP -0.150743243476538 0.0177144148281411 NA NA NA hsa-miR-200c-3p PSIP1 3.50132673580082 2.42716349086937e-15 -0.69271775262539 0.00369263349962018 MirTarget;miRNATAP -0.170802465591392 4.23477325340041e-12 NA NA NA hsa-miR-200c-3p PTHLH 3.50132673580082 2.42716349086937e-15 -0.637337427958821 0.359541326845111 MirTarget -0.321174456367142 1.03989013458563e-05 NA NA NA hsa-miR-200c-3p PTPN21 3.50132673580082 2.42716349086937e-15 -1.00705050330315 2.27967729064557e-07 miRNATAP -0.118883981502558 6.41241001696586e-09 NA NA NA hsa-miR-200c-3p PTPRD 3.50132673580082 2.42716349086937e-15 -3.62979486144354 1.88740064210481e-09 miRNAWalker2_validate -0.631789922953883 8.61910701410587e-25 NA NA NA hsa-miR-200c-3p PTPRZ1 3.50132673580082 2.42716349086937e-15 -3.06984706543687 0.00081651312572712 MirTarget;miRNATAP -0.421932299469652 1.27346651460668e-05 NA NA NA hsa-miR-200c-3p PYGO1 3.50132673580082 2.42716349086937e-15 -2.10178219794221 4.03238443886891e-05 mirMAP -0.410995557662133 7.28369892582507e-15 NA NA NA hsa-miR-200c-3p RASSF2 3.50132673580082 2.42716349086937e-15 -1.41203583911444 3.41019630784437e-05 miRNAWalker2_validate -0.163814129885691 5.29293063059862e-06 NA NA NA hsa-miR-200c-3p RASSF8 3.50132673580082 2.42716349086937e-15 -1.48887021923134 4.62579164697906e-06 miRNATAP -0.314866562878241 1.49954673919764e-21 NA NA NA hsa-miR-200c-3p RBM20 3.50132673580082 2.42716349086937e-15 -2.46227191748389 1.31938346873951e-07 MirTarget -0.267854349947843 5.72459825885424e-08 NA NA NA hsa-miR-200c-3p RECK 3.50132673580082 2.42716349086937e-15 -2.38610578026315 7.82688892259109e-14 miRNATAP -0.450430701110267 5.413160156224e-48 27574450;24647918 MiR 200c promotes bladder cancer cell migration and invasion by directly targeting RECK; The luciferase reporter assay showed that RECK was a direct target of miR-200c;Finally we demonstrated that expression of miR-200c in H460 cells suppressed cell growth by targeting RECK followed by activation of the JNK signaling pathway and ER stress; Collectively these data show that miR-200c expression sensitizes H460 cells to RESV and this is likely due to RECK expression cell migration; bladder cancer;lung cancer hsa-miR-200c-3p REEP1 3.50132673580082 2.42716349086937e-15 -4.34753961523252 3.78306600846853e-15 MirTarget;miRNATAP -0.60798144951987 9.68205191169038e-27 NA NA NA hsa-miR-200c-3p RELN 3.50132673580082 2.42716349086937e-15 -4.70097153618157 2.41994737445055e-14 MirTarget -0.654129820157615 6.78543521649521e-25 NA NA NA hsa-miR-200c-3p RFTN2 3.50132673580082 2.42716349086937e-15 -1.41911132096922 1.31506326408267e-08 MirTarget -0.168323840026862 1.47293350292805e-10 NA NA NA hsa-miR-200c-3p RGL1 3.50132673580082 2.42716349086937e-15 -1.51925487686695 6.14848968356696e-09 MirTarget;miRNATAP -0.267570265729395 7.95898817127779e-24 NA NA NA hsa-let-7i-5p RICTOR 0.412877696970403 0.00622731051981756 -0.0636558558251128 0.690801456304219 MirTarget;miRNATAP -0.181498389332032 0.000474512978277903 NA NA NA hsa-miR-139-5p RICTOR -1.52606598644743 1.20474151350665e-08 -0.0636558558251128 0.690801456304219 MirTarget;PITA;miRanda -0.117309140283128 3.26793845059091e-05 NA NA NA hsa-miR-140-3p RICTOR 0.0608890720479334 0.727716871248724 -0.0636558558251128 0.690801456304219 MirTarget;PITA;miRNATAP -0.139944872162773 0.00177546724259963 NA NA NA hsa-miR-218-5p RICTOR -0.573801507392184 0.0551983860126703 -0.0636558558251128 0.690801456304219 miRNAWalker2_validate;miRTarBase;miRNATAP -0.128099349308607 5.27766413859692e-07 NA NA NA hsa-miR-495-3p RICTOR -0.0847115949846082 0.763475496144456 -0.0636558558251128 0.690801456304219 MirTarget -0.143309782555465 1.46249599436837e-07 NA NA NA hsa-miR-497-5p RICTOR 0.0257087130056286 0.918145413833358 -0.0636558558251128 0.690801456304219 MirTarget;miRNATAP -0.107838893771902 0.000492230040753755 NA NA NA hsa-miR-660-5p RICTOR 1.82692095272076 1.92040083607196e-13 -0.0636558558251128 0.690801456304219 MirTarget -0.125254027693193 3.16011915894253e-05 NA NA NA hsa-miR-200c-3p RIMKLB 3.50132673580082 2.42716349086937e-15 -0.825833788774339 0.00780804620647977 MirTarget;miRNATAP -0.172631359326516 1.02643399584783e-07 NA NA NA hsa-miR-200c-3p RIMS2 3.50132673580082 2.42716349086937e-15 -2.03271632474241 0.00172161214577439 MirTarget -0.16389295395964 0.0172649663912246 NA NA NA hsa-miR-200c-3p RIN2 3.50132673580082 2.42716349086937e-15 0.108109453171399 0.623647304950009 miRNAWalker2_validate -0.104557875226358 5.52655449672694e-06 NA NA NA hsa-miR-200c-3p RND3 3.50132673580082 2.42716349086937e-15 -1.48017982993852 1.2895596822753e-07 MirTarget;miRNATAP -0.16584902775001 2.0865793459284e-08 23821457 MicroRNA 200c regulates the sensitivity of chemotherapy of gastric cancer SGC7901/DDP cells by directly targeting RhoE gastric cancer hsa-miR-125b-5p RPS6KA1 -1.16462950151259 0.000288900271798384 1.34988540411024 1.15370611659724e-11 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.13692356644705 6.2422468067932e-06 NA NA NA hsa-miR-139-5p RPS6KA1 -1.52606598644743 1.20474151350665e-08 1.34988540411024 1.15370611659724e-11 miRanda -0.104159748301514 0.00411281450359946 NA NA NA hsa-let-7g-3p RPS6KA2 3.26398061402445 3.96263126107645e-25 -1.89918037721253 3.87074381310148e-13 MirTarget -0.246721753553459 3.41630640648566e-10 NA NA NA hsa-miR-1271-5p RPS6KA2 0.970418832993172 0.000609742584380688 -1.89918037721253 3.87074381310148e-13 mirMAP -0.20251993530887 9.27638787048565e-06 NA NA NA hsa-miR-130b-5p RPS6KA2 2.9963110846538 1.98883029416455e-18 -1.89918037721253 3.87074381310148e-13 mirMAP -0.235363829031829 1.54980286279085e-10 NA NA NA hsa-miR-17-5p RPS6KA2 3.2710598467455 9.93128340539455e-27 -1.89918037721253 3.87074381310148e-13 TargetScan -0.308938986160142 1.53086675306477e-15 NA NA NA hsa-miR-181a-2-3p RPS6KA2 2.19062681262366 3.81790102612782e-13 -1.89918037721253 3.87074381310148e-13 mirMAP -0.185814296672575 8.43603766197703e-06 NA NA NA hsa-miR-185-3p RPS6KA2 2.3922478518806 1.3373426768452e-14 -1.89918037721253 3.87074381310148e-13 MirTarget -0.23896304263491 2.26811072773796e-09 NA NA NA hsa-miR-193a-3p RPS6KA2 1.60460546928078 2.86169793322984e-07 -1.89918037721253 3.87074381310148e-13 mirMAP -0.182027317307988 8.38861562840483e-06 NA NA NA hsa-miR-193b-3p RPS6KA2 2.25711804611899 4.1940744806631e-14 -1.89918037721253 3.87074381310148e-13 mirMAP -0.311500359089077 3.53991075205589e-14 NA NA NA hsa-miR-19a-3p RPS6KA2 3.42309334186656 3.02671914353412e-28 -1.89918037721253 3.87074381310148e-13 MirTarget -0.274673751333933 6.75653405295878e-13 NA NA NA hsa-miR-19b-3p RPS6KA2 2.49529833021187 1.57028265846699e-23 -1.89918037721253 3.87074381310148e-13 MirTarget -0.319321802710713 4.74464788644084e-11 NA NA NA hsa-miR-200c-3p RPS6KA2 3.50132673580082 2.42716349086937e-15 -1.89918037721253 3.87074381310148e-13 miRNATAP -0.129334089352011 4.4517289901593e-06 NA NA NA hsa-miR-21-3p RPS6KA2 2.19296355304364 4.63665722759779e-15 -1.89918037721253 3.87074381310148e-13 MirTarget -0.272784541769791 7.52288789174635e-10 NA NA NA hsa-miR-26b-5p RPS6KA2 0.885393662798425 3.2116297961629e-06 -1.89918037721253 3.87074381310148e-13 miRNATAP -0.227177310507267 0.000899668091721707 NA NA NA hsa-miR-3065-5p RPS6KA2 2.74629919868982 1.86846589298284e-08 -1.89918037721253 3.87074381310148e-13 mirMAP -0.129392772331137 5.16506987695122e-05 NA NA NA hsa-miR-30e-5p RPS6KA2 1.23904909539663 1.35561917122157e-09 -1.89918037721253 3.87074381310148e-13 MirTarget -0.167397027801108 0.00795729353132801 NA NA NA hsa-miR-3127-5p RPS6KA2 1.51846438737133 3.59571251672767e-07 -1.89918037721253 3.87074381310148e-13 mirMAP -0.13587142025251 0.00161943122406181 NA NA NA hsa-miR-532-3p RPS6KA2 1.96631878320218 4.53421954361695e-13 -1.89918037721253 3.87074381310148e-13 MirTarget;mirMAP -0.217249391578203 2.76835498444362e-06 NA NA NA hsa-miR-589-5p RPS6KA2 1.71990116752371 8.310889042056e-14 -1.89918037721253 3.87074381310148e-13 mirMAP -0.333681503852927 7.42768576140755e-10 NA NA NA hsa-miR-93-3p RPS6KA2 2.85383869771942 5.64481766902125e-23 -1.89918037721253 3.87074381310148e-13 MirTarget -0.236183258286661 2.11710105875058e-08 NA NA NA hsa-let-7d-5p RPS6KA3 1.33236798905207 1.1741085658466e-13 -0.370806818018999 0.0220707753218686 miRNATAP -0.114489938702704 0.00756705340948625 NA NA NA hsa-miR-136-5p RPS6KA3 2.09637138292451 1.50140005592201e-10 -0.370806818018999 0.0220707753218686 mirMAP -0.117791568961288 3.67256904611671e-07 NA NA NA hsa-miR-181a-5p RPS6KA3 2.29556023480783 1.8138457900616e-21 -0.370806818018999 0.0220707753218686 MirTarget;mirMAP;miRNATAP -0.121039283729606 8.78983023529811e-05 NA NA NA hsa-miR-181c-5p RPS6KA3 1.58587920618301 1.57506918816933e-10 -0.370806818018999 0.0220707753218686 MirTarget;mirMAP;miRNATAP -0.137925322197845 7.60328156936309e-06 NA NA NA hsa-miR-186-5p RPS6KA3 1.47445398888668 3.0781726595413e-15 -0.370806818018999 0.0220707753218686 MirTarget;mirMAP;miRNATAP -0.111734638474146 0.00635139835787659 NA NA NA hsa-miR-21-5p RPS6KA3 2.73773305747971 1.38864982139576e-43 -0.370806818018999 0.0220707753218686 miRNAWalker2_validate;mirMAP;miRNATAP -0.115651579127679 0.00124546897217506 NA NA NA hsa-miR-320a RPS6KA3 0.438165828017084 0.0390159073347133 -0.370806818018999 0.0220707753218686 miRNAWalker2_validate;miRanda -0.105734074591902 0.00443346974555563 NA NA NA hsa-miR-1271-5p RPS6KA6 0.970418832993172 0.000609742584380688 -0.643070571271251 0.264542356112038 MirTarget -0.28783551839478 0.00344430588607334 NA NA NA hsa-miR-199a-3p RPS6KA6 0.640600337515787 0.0380326905134914 -0.643070571271251 0.264542356112038 MirTarget -0.494218120175028 2.93790214049553e-08 NA NA NA hsa-miR-199b-3p RPS6KA6 0.643923492750702 0.0371742251925406 -0.643070571271251 0.264542356112038 MirTarget -0.493553319945077 2.99976098785352e-08 NA NA NA hsa-miR-217 RPS6KA6 0.608024397387488 0.199352491710517 -0.643070571271251 0.264542356112038 miRanda -0.218929391103907 0.000280286435780485 NA NA NA hsa-miR-338-5p RPS6KA6 -0.577691606146419 0.0472212680542825 -0.643070571271251 0.264542356112038 MirTarget -0.211094505598065 0.0294237857264803 NA NA NA hsa-miR-424-5p RPS6KA6 1.61930224569578 1.89642549274994e-10 -0.643070571271251 0.264542356112038 MirTarget -0.275006218909343 0.0107505875800356 NA NA NA hsa-miR-655-3p RPS6KA6 0.485339318272148 0.137014658258732 -0.643070571271251 0.264542356112038 MirTarget -0.294210829929277 0.000704709579255314 NA NA NA hsa-miR-708-3p RPS6KA6 2.80907765282502 3.07460722669281e-14 -0.643070571271251 0.264542356112038 MirTarget -0.173132616422874 0.017829398044062 NA NA NA hsa-miR-200c-3p RUSC2 3.50132673580082 2.42716349086937e-15 -1.59852075923141 8.04308093421491e-11 miRNATAP -0.332927858785705 2.94321058698259e-44 NA NA NA hsa-miR-200c-3p SCHIP1 3.50132673580082 2.42716349086937e-15 -1.15670143162604 1.15787017339655e-06 miRNATAP -0.248243798490195 3.81900317798344e-25 NA NA NA hsa-miR-200c-3p SCN2A 3.50132673580082 2.42716349086937e-15 -1.29167455183038 0.0301757402573598 MirTarget;miRNATAP -0.260085919342346 3.27763228347355e-05 NA NA NA hsa-miR-200c-3p SCN3A 3.50132673580082 2.42716349086937e-15 -2.32699009748223 7.40591172107087e-07 mirMAP -0.315258532252987 1.58612630302652e-10 NA NA NA hsa-miR-200c-3p SCUBE3 3.50132673580082 2.42716349086937e-15 -2.48127471582544 2.66234551923326e-07 mirMAP -0.385334863448361 1.41921436053361e-14 NA NA NA hsa-miR-200c-3p SDC2 3.50132673580082 2.42716349086937e-15 -2.00706478458987 1.28300608152733e-09 miRNATAP -0.331251769489888 1.17181582498384e-22 NA NA NA hsa-miR-200c-3p SEC23A 3.50132673580082 2.42716349086937e-15 -0.851484611346241 3.97374078989646e-06 MirTarget;miRNATAP -0.213188508576225 1.57444863860176e-31 21593139 A computational analysis predicted the 3'-UTR of the SEC23A gene as a potential target for both miR-375 and miR-200c; Here we show that the 3'-UTR of SEC23A mRNA is indeed a target for miR-375 and miR-200c and that both miRNAs downregulate Sec23A protein expression when ectopically expressed in human 293T cells; In primary samples of CaP we found a direct correlation between reduction of SEC23A mRNA and overexpression of miR-375 but not of miR-200c prostate cancer hsa-miR-200c-3p SEMA6D 3.50132673580082 2.42716349086937e-15 -1.94164031321549 1.1489424743785e-07 miRNATAP -0.25083186056663 6.73131670333037e-11 NA NA NA hsa-miR-200c-3p SERINC1 3.50132673580082 2.42716349086937e-15 -1.06295473287643 5.49350211423462e-13 MirTarget;miRNATAP -0.121663127328767 3.49946305209744e-15 NA NA NA hsa-miR-200c-3p SETD7 3.50132673580082 2.42716349086937e-15 -1.13463057726458 1.78342966519954e-10 miRNATAP -0.160518940134969 2.72739618225597e-18 NA NA NA hsa-miR-200c-3p SFMBT2 3.50132673580082 2.42716349086937e-15 -1.41454985454287 0.000416308526551551 mirMAP -0.349056411453125 1.56123571326781e-17 NA NA NA hsa-miR-200c-3p SGCD 3.50132673580082 2.42716349086937e-15 -3.54960120603853 1.88168939363754e-09 mirMAP -0.674570017915175 5.40649659440121e-30 NA NA NA hsa-miR-200c-3p SGIP1 3.50132673580082 2.42716349086937e-15 -0.435449323177095 0.231015167394361 MirTarget -0.324279345851272 1.23552072204793e-18 NA NA NA hsa-miR-200c-3p SGPP1 3.50132673580082 2.42716349086937e-15 -0.148910476883497 0.606055761679441 MirTarget -0.17336001507914 7.1513549714889e-09 NA NA NA hsa-miR-200c-3p SH3PXD2A 3.50132673580082 2.42716349086937e-15 -0.987155493438988 1.02406192375196e-05 miRNATAP -0.103026328658852 1.33396126608335e-05 NA NA NA hsa-miR-200c-3p SHE 3.50132673580082 2.42716349086937e-15 -2.12174612226388 6.45456472105851e-13 mirMAP -0.346237361482731 2.73958243144482e-31 NA NA NA hsa-miR-200c-3p SIRPA 3.50132673580082 2.42716349086937e-15 -0.55339733363088 0.119266182012343 MirTarget -0.382259349502016 1.54540408894156e-27 NA NA NA hsa-miR-200c-3p SLC16A12 3.50132673580082 2.42716349086937e-15 -0.975164130666574 0.0455225768500397 mirMAP;miRNATAP -0.312853270378774 6.26610008780758e-10 NA NA NA hsa-miR-200c-3p SLC16A2 3.50132673580082 2.42716349086937e-15 -1.53927355158781 4.3817377775803e-06 miRNATAP -0.39526770609163 6.41326684117318e-33 NA NA NA hsa-miR-200c-3p SLC1A2 3.50132673580082 2.42716349086937e-15 -1.63926856184029 0.00011983867188635 MirTarget;miRNATAP -0.273838691448261 7.59924661422873e-10 NA NA NA hsa-miR-200c-3p SLC30A4 3.50132673580082 2.42716349086937e-15 -1.12863913918651 0.00370195756593126 mirMAP -0.373474811983133 1.75276250787592e-21 NA NA NA hsa-miR-200c-3p SLC35B4 3.50132673580082 2.42716349086937e-15 -0.0558520609113842 0.697638933075465 MirTarget -0.116261042575822 1.73957643663548e-15 NA NA NA hsa-miR-200c-3p SLC39A8 3.50132673580082 2.42716349086937e-15 0.248276675119964 0.380319177862353 MirTarget -0.186297567113022 1.88652901799459e-10 NA NA NA hsa-miR-200c-3p SLC6A17 3.50132673580082 2.42716349086937e-15 0.941104200796897 0.0568131902197341 mirMAP;miRNATAP -0.338531774539117 3.42406203332552e-11 NA NA NA hsa-miR-200c-3p SNAI2 3.50132673580082 2.42716349086937e-15 -0.280307189347724 0.489884936104145 miRNATAP -0.183480437180395 1.58844201912264e-05 NA NA NA hsa-miR-200c-3p SNAP25 3.50132673580082 2.42716349086937e-15 -1.14591384974572 0.0327342558924054 MirTarget;miRNATAP -0.463254365225422 2.23415552337194e-17 NA NA NA hsa-miR-200c-3p SOX6 3.50132673580082 2.42716349086937e-15 -2.16170894059309 7.49520430040923e-06 mirMAP;miRNATAP -0.138254970031974 0.00723892899868318 NA NA NA hsa-miR-200c-3p SPRED1 3.50132673580082 2.42716349086937e-15 -0.64004595524649 0.00626859347930208 miRNATAP -0.179812130749086 7.93557682460323e-14 NA NA NA hsa-miR-200c-3p SRF 3.50132673580082 2.42716349086937e-15 -1.54762802860391 1.84904741152095e-30 miRNATAP -0.164183916101306 6.86000844726545e-31 NA NA NA hsa-miR-200c-3p SSBP2 3.50132673580082 2.42716349086937e-15 -1.50095838408439 5.47169471767289e-08 mirMAP -0.195372913363616 1.4641661073489e-11 NA NA NA hsa-miR-200c-3p SSFA2 3.50132673580082 2.42716349086937e-15 -0.51178832437508 0.043734278908624 MirTarget -0.106538225510806 6.40312293136217e-05 NA NA NA hsa-miR-200c-3p ST3GAL2 3.50132673580082 2.42716349086937e-15 -0.445772259800494 0.0300266062096944 MirTarget;miRNATAP -0.230409451920264 3.75845543120383e-30 NA NA NA hsa-miR-200c-3p ST6GAL2 3.50132673580082 2.42716349086937e-15 -1.3142379434542 0.0257348756173388 mirMAP -0.261766619296355 2.3628803892543e-05 NA NA NA hsa-miR-200c-3p ST8SIA2 3.50132673580082 2.42716349086937e-15 1.00416696041788 0.0930911785259641 mirMAP -0.213312503342201 0.000707863570829797 NA NA NA hsa-miR-200c-3p STARD8 3.50132673580082 2.42716349086937e-15 -1.75930604958348 9.33516853968586e-11 mirMAP -0.379204663888607 9.45016942553162e-48 NA NA NA hsa-miR-200c-3p SULF1 3.50132673580082 2.42716349086937e-15 0.171691676108908 0.757613998121678 MirTarget;miRNATAP -0.49902968093352 7.30785365573536e-19 NA NA NA hsa-miR-200c-3p SV2B 3.50132673580082 2.42716349086937e-15 -2.33341367960543 7.07116491599061e-05 mirMAP -0.600923702564399 2.71705555424813e-24 NA NA NA hsa-miR-200c-3p SYDE1 3.50132673580082 2.42716349086937e-15 -0.810810064122849 0.0022212919239998 MirTarget;miRNATAP -0.364874012707535 2.34902550550674e-48 NA NA NA hsa-miR-200c-3p SYNC 3.50132673580082 2.42716349086937e-15 -0.957409925380232 0.0645528551303327 MirTarget -0.270682536919566 5.75769267580588e-07 NA NA NA hsa-miR-200c-3p SYT11 3.50132673580082 2.42716349086937e-15 -2.11616848018482 5.62916826382274e-11 mirMAP -0.470440774817395 4.40014158696989e-53 NA NA NA hsa-miR-200c-3p TBX18 3.50132673580082 2.42716349086937e-15 -2.20112491662338 0.00124808322159382 MirTarget -0.476341627053578 1.65785424624472e-11 NA NA NA hsa-miR-200c-3p TCF4 3.50132673580082 2.42716349086937e-15 -1.61270531688003 6.6047419057989e-09 mirMAP;miRNATAP -0.315861779424697 8.06031609720187e-30 NA NA NA hsa-miR-200c-3p TCF7L1 3.50132673580082 2.42716349086937e-15 -1.29563210038614 0.00022110689990566 miRNAWalker2_validate -0.321512044267134 2.09544895880279e-19 NA NA NA hsa-miR-200c-3p TCP11L1 3.50132673580082 2.42716349086937e-15 -0.403764783267501 0.0968250910404959 MirTarget -0.241285719807731 3.40514116790965e-23 NA NA NA hsa-miR-200c-3p TEAD1 3.50132673580082 2.42716349086937e-15 -1.49495998391161 1.96516757915294e-13 miRNATAP -0.192783618175601 7.30243782570054e-20 NA NA NA hsa-miR-200c-3p TES 3.50132673580082 2.42716349086937e-15 -1.08685329583047 1.15308429217781e-07 MirTarget -0.119205847148141 3.61522992706086e-08 NA NA NA hsa-miR-200c-3p TFEC 3.50132673580082 2.42716349086937e-15 0.01663444290745 0.970577333140702 MirTarget -0.381763051019323 8.25525605424634e-17 NA NA NA hsa-miR-200c-3p TFPI 3.50132673580082 2.42716349086937e-15 -1.31178861447988 0.000159567700514258 MirTarget -0.206080737807578 1.47781165026496e-08 NA NA NA hsa-miR-200c-3p THEMIS 3.50132673580082 2.42716349086937e-15 -1.30669866510856 0.0118699940008927 mirMAP -0.306491960115639 1.52135462691567e-08 NA NA NA hsa-miR-200c-3p THRA 3.50132673580082 2.42716349086937e-15 -1.80486534711542 1.86472212451361e-16 mirMAP -0.221707189223359 2.68678169555829e-22 NA NA NA hsa-miR-200c-3p TIMP2 3.50132673580082 2.42716349086937e-15 -1.7485334269093 7.3578966378154e-06 miRTarBase -0.476890623570835 8.82517913264524e-36 NA NA NA hsa-miR-200c-3p TLN1 3.50132673580082 2.42716349086937e-15 -1.45515106009239 3.18740725534339e-16 miRNATAP -0.28504098114337 3.94646937052157e-66 NA NA NA hsa-miR-200c-3p TLN2 3.50132673580082 2.42716349086937e-15 -1.13678695432202 2.37164982459728e-06 miRNATAP -0.138116523337088 5.16279101952154e-08 NA NA NA hsa-miR-200c-3p TMEM170B 3.50132673580082 2.42716349086937e-15 -0.889417316317811 0.00246966185092237 miRNATAP -0.128416783647493 3.31261227696871e-05 NA NA NA hsa-miR-200c-3p TNFRSF11B 3.50132673580082 2.42716349086937e-15 0.521283699352378 0.32045562869016 miRNATAP -0.251159746127495 4.76271904987642e-06 NA NA NA hsa-miR-200c-3p TRIL 3.50132673580082 2.42716349086937e-15 -1.46802493073098 2.0969564350264e-05 MirTarget -0.296795562953484 5.36511563035758e-17 NA NA NA hsa-miR-200c-3p TRIM44 3.50132673580082 2.42716349086937e-15 -0.65549929625214 0.0026112531188157 MirTarget -0.148947024228969 4.02379735360466e-11 NA NA NA hsa-miR-200c-3p TSC22D1 3.50132673580082 2.42716349086937e-15 -1.75361245196073 6.61831957327972e-18 MirTarget;miRNATAP -0.127542242232715 6.8318793631812e-09 NA NA NA hsa-miR-200c-3p TUBB2A 3.50132673580082 2.42716349086937e-15 -0.677785072656842 0.0628952222897361 MirTarget;miRNATAP -0.301714284442487 4.90632032076582e-16 NA NA NA hsa-miR-200c-3p TUBB3 3.50132673580082 2.42716349086937e-15 2.12658714594088 1.45483266022161e-07 miRNAWalker2_validate;miRTarBase -0.103328819446613 0.0171800160429241 23074172;23394580 miR-200c increases sensitivity to taxanes in vitro by targeting class III β-tubulin gene TUBB3 a tubulin known to mediate chemoresistance;This study assessed the role of miR-200c as regulator of class III β-tubulin TUBB3 a factor associated with drug-resistance and poor prognosis in ovarian cancer; Crosslinking-coupled affinity purification method and ribonucleic-immunoprecipitation assay were used to characterise the complexes between miR-200c HuR and 3'UTR region of TUBB3 mRNA; Nanofluidic technology and immunohistochemistry were used to analyze the expression of HuR TUBB3 and miR-200c in 220 ovarian cancer patients; In A2780 cells miR-200c targeted TUBB3 3'UTR while a positive correlation was observed between miR-200c and TUBB3 expression in most of the other cell lines; This study suggests a model for the combined regulatory activity of miR-200c and HuR on TUBB3 expression in ovarian cancer drug resistance;worse prognosis;drug resistance ovarian cancer;ovarian cancer hsa-miR-26a-5p ULK1 0.0464832722967259 0.752628386912329 0.168631118107132 0.26676283173824 miRNATAP -0.17543741443891 0.000545660569952753 NA NA NA hsa-miR-338-5p ULK1 -0.577691606146419 0.0472212680542825 0.168631118107132 0.26676283173824 PITA -0.136183558809384 5.60724774968058e-08 NA NA NA hsa-let-7d-5p ULK2 1.33236798905207 1.1741085658466e-13 -0.582426572411284 0.00379371000646104 MirTarget -0.111425190965775 0.0372609723503154 NA NA NA hsa-let-7e-5p ULK2 0.860104282510173 6.04758298373779e-05 -0.582426572411284 0.00379371000646104 MirTarget -0.106151678752928 0.0198281047608298 NA NA NA hsa-let-7f-1-3p ULK2 1.55054488387679 7.31326775537952e-11 -0.582426572411284 0.00379371000646104 MirTarget -0.125305835260512 0.00247463325840322 NA NA NA hsa-let-7g-5p ULK2 1.20061455355116 1.50237505511483e-12 -0.582426572411284 0.00379371000646104 MirTarget -0.165050528466831 0.00363550241375785 NA NA NA hsa-let-7i-5p ULK2 0.412877696970403 0.00622731051981756 -0.582426572411284 0.00379371000646104 MirTarget -0.172181963679009 0.00898713806249386 NA NA NA hsa-miR-140-5p ULK2 0.844753502512594 3.73722278438606e-05 -0.582426572411284 0.00379371000646104 miRanda -0.184727637468753 9.90523092823506e-05 NA NA NA hsa-miR-186-5p ULK2 1.47445398888668 3.0781726595413e-15 -0.582426572411284 0.00379371000646104 MirTarget -0.157734543365668 0.00196013457709713 NA NA NA hsa-miR-22-3p ULK2 1.21545661147757 1.61670170137775e-13 -0.582426572411284 0.00379371000646104 MirTarget -0.16192209246504 0.00556684151656764 NA NA NA hsa-miR-26a-5p ULK2 0.0464832722967259 0.752628386912329 -0.582426572411284 0.00379371000646104 MirTarget -0.137064696597495 0.0436845224449156 NA NA NA hsa-miR-26b-5p ULK2 0.885393662798425 3.2116297961629e-06 -0.582426572411284 0.00379371000646104 MirTarget -0.240421415650889 2.31215037237229e-06 26920049 MiR 26b inhibits autophagy by targeting ULK2 in prostate cancer cells; We found that miR-26b inhibited autophagy in PC-3 and C4-2 cells through down-regulation of ULK2 expression; Dual luciferase reporter assays showed that miR-26b binds the 3'UTR of ULK2 suggesting that ULK2 is a direct target of miR-26b; Real-time PCR and Western blot analysis confirmed that over-expression of miR-26b reduced ULK2 mRNA and protein levels; Taken together our findings indicate that mir-26b inhibits autophagy through targeting ULK2 which is up-regulated in PCa prostate cancer hsa-miR-361-5p ULK2 0.971859117235239 5.30236555707088e-09 -0.582426572411284 0.00379371000646104 miRanda;miRNATAP -0.119325589320004 0.0417407337553628 NA NA NA hsa-miR-362-3p ULK2 2.0756816987665 3.89026064579331e-12 -0.582426572411284 0.00379371000646104 miRNATAP -0.107486427614139 0.00106480930288894 NA NA NA hsa-miR-576-5p ULK2 2.20467023993664 3.4053475193793e-19 -0.582426572411284 0.00379371000646104 mirMAP -0.157539740944837 3.14539499378473e-05 NA NA NA hsa-miR-582-5p ULK2 0.609226359812689 0.032988717891497 -0.582426572411284 0.00379371000646104 miRNATAP -0.156069010259381 4.20782665050971e-06 NA NA NA hsa-miR-590-3p ULK2 2.59289455139753 1.03200520972022e-21 -0.582426572411284 0.00379371000646104 mirMAP -0.16610742386826 2.02217872445913e-06 NA NA NA hsa-miR-125b-5p ULK3 -1.16462950151259 0.000288900271798384 0.488619672684837 0.00278933779897925 miRNAWalker2_validate -0.134861810614726 2.44640037676076e-08 NA NA NA hsa-miR-200c-3p VASH1 3.50132673580082 2.42716349086937e-15 -0.337969458904786 0.116732741160964 MirTarget;miRNATAP -0.240437294328506 6.72808562672583e-30 NA NA NA hsa-miR-200c-3p VAT1L 3.50132673580082 2.42716349086937e-15 -1.21093342860372 0.00422286393153055 MirTarget;miRNATAP -0.302839487155164 4.55742927477905e-12 NA NA NA hsa-miR-1-3p VEGFA -3.48370702447685 1.98579484008516e-13 0.471653090802802 0.0989904385682923 MirTarget -0.202978528176548 1.57292170658149e-13 24966896 The ectopic expression of miR-1 and miR-145 in NOZ cells significantly inhibited cell viability and colony formation P<0.01 and reduced gene expression of VEGF-A and AXL bladder cancer hsa-miR-133a-3p VEGFA -3.38501431117712 1.32336729742128e-13 0.471653090802802 0.0989904385682923 miRNAWalker2_validate -0.190996958246616 2.70660605752725e-11 NA NA NA hsa-miR-134-5p VEGFA 0.141163006984518 0.655334296084178 0.471653090802802 0.0989904385682923 miRNAWalker2_validate;miRTarBase;MirTarget -0.180227374251871 3.58435465670397e-05 NA NA NA hsa-miR-145-5p VEGFA -1.55259331973517 9.97889123247165e-07 0.471653090802802 0.0989904385682923 miRNAWalker2_validate;miRTarBase -0.277645238248207 4.72205041776188e-11 24966896;24781864;22472569 The ectopic expression of miR-1 and miR-145 in NOZ cells significantly inhibited cell viability and colony formation P<0.01 and reduced gene expression of VEGF-A and AXL;Overexpression of miR-145 in thyroid cancer cell lines resulted in: decreased cell proliferation migration invasion VEGF secretion and E-cadherin expression; In vivo miR-145 overexpression decreased tumor growth and metastasis in a xenograft mouse model and VEGF secretion;Furthermore the results showed that vascular endothelial growth factor VEGF expression was down-regulated in osteosarcoma cells after miR-145 transfection; On the basis of these results we performed the luciferase assay and verified that miR-145 could down-regulate VEGF at the translational level by partially binding to VEGF 3' untranslated region 3'UTR; One of the mechanisms is the down-regulation of VEGF expression by miR-145 by binding to the 3'UTR of VEGF mRNA specifically ;metastasis; bladder cancer;thyroid cancer;sarcoma hsa-miR-150-5p VEGFA -0.105827294491332 0.799351458244375 0.471653090802802 0.0989904385682923 miRNAWalker2_validate;miRTarBase -0.164137084593398 6.0374913950269e-07 NA NA NA hsa-miR-195-5p VEGFA -1.44753678070504 8.70594292149271e-09 0.471653090802802 0.0989904385682923 miRNAWalker2_validate;miRTarBase;MirTarget -0.21863878149299 5.11037236008283e-05 27574422;23468064;26823724 In this study we used a new cationic peptide disulfide cross-linked stearylated polyarginine peptide modified with histidine H3R5 as a reducible vector cell penetrating peptide-modified aptamer ST21 with specific binding to HCC cells to conjugate to peptide H3R5 as the targeting probe miRNA-195 miR195 as a powerful gene drug to inhibit VEGF and fasudil to suppress vasculogenic mimicry by blocking ROCK2 all of which were simultaneously encapsulated in the same nanoparticles;Furthermore we revealed that miR-195 down-regulation resulted in enhanced VEGF levels in the tumor microenvironment which subsequently activated VEGF receptor 2 signaling in endothelial cells and thereby promoted angiogenesis;MiR 195 is a key negative regulator of hepatocellular carcinoma metastasis by targeting FGF2 and VEGFA; Luciferase reporter and ELISA assay prove that hematogenous metastasis related genes including FGF2 and VEGFA are the target genes of miR-195; Taken together our results suggest that miR-195 a tumor suppressor miRNA contributes to the lung metastasis of HCC by negatively regulating FGF2 and VEGFA providing key implications of miR-195 for the therapeutic intervention of HCC ;;metastasis liver cancer;liver cancer;liver cancer hsa-miR-199a-5p VEGFA 0.592984035153911 0.0674836634175293 0.471653090802802 0.0989904385682923 miRanda;miRNATAP -0.205612739501636 1.1489897892283e-06 25444917 In addition co-transfection with miR-199a mimic reversed the CCL5-mediated VEGF expression and angiogenesis in vitro and in vivo sarcoma hsa-miR-199b-5p VEGFA 0.218704279044827 0.519493319158441 0.471653090802802 0.0989904385682923 miRanda -0.175899050515122 1.43171320791549e-05 NA NA NA hsa-miR-29a-3p VEGFA -0.35074463683376 0.161238718982428 0.471653090802802 0.0989904385682923 MirTarget -0.313847513848792 9.68544057650496e-09 24209632 miR 29a suppresses growth and invasion of gastric cancer cells in vitro by targeting VEGF A; Furthermore western blot combined with the luciferase reporter assays demonstrate that vascular endothelial growth factor A VEGF-A is direct target of miR-29a; This is the first time miR-29a was found to suppress the tumor microvessel density in gastric cancer by targeting VEGF-A gastric cancer hsa-miR-342-3p VEGFA 1.49115144672245 1.43879249744621e-07 0.471653090802802 0.0989904385682923 miRanda;miRNATAP -0.166390639835536 0.000539599594707828 23408138 Statistically significant associations were observed between miR-342 and ER HER2 and vascular endothelial growth factor VEGF status in the human breast cancer samples and the levels of miR-342 gradually increased as ERα mRNA expression increased breast cancer hsa-miR-374b-5p VEGFA 0.0654362503857184 0.722673188879465 0.471653090802802 0.0989904385682923 MirTarget -0.254824056474554 0.000792850845311603 NA NA NA hsa-miR-655-3p VEGFA 0.485339318272148 0.137014658258732 0.471653090802802 0.0989904385682923 MirTarget -0.164823030617487 0.000126415331270495 NA NA NA hsa-miR-128-3p VEGFC 1.63756041666078 6.79626586407187e-14 -0.457873556695705 0.178610332401836 miRNAWalker2_validate;MirTarget -0.377058704312277 2.16798927147771e-07 26722309;25001183 miR 128 downregulation promotes growth and metastasis of bladder cancer cells and involves VEGF C upregulation; To investigate the regulation of miR-128 on VEGF-C expression and their effects on proliferation and metastasis of bladder cancer T24 and 5637 BC cells were transfected with pre-miR-128 anti-miR-128 and their respective negative control; miR-128 was downregulated in BC tissues and cell lines while the expression levels of VEGF-C were upregulated; The present results indicated that miR-128 negatively regulated VEGF-C expression in BC T24 and 5637 BC cells; VEGF-C is a direct target of miR-128 in BC cells;Interestingly ectopic miR-128 overexpression could significantly inhibit vascular endothelial growth factor VEGF-C expression and reduce the activity of a luciferase reporter containing the VEGF-C 3'-untranslated region; These findings suggest that miR-128 could play a role in NSCLC tumourigenesis at least in part by modulation of angiogenesis and lymphangiogenesis through targeting VEGF-C and could simultaneously block ERK AKT and p38 signalling pathways metastasis; bladder cancer;lung squamous cell cancer hsa-miR-27b-3p VEGFC 0.196007704287769 0.295630157035388 -0.457873556695705 0.178610332401836 MirTarget -0.184894953706514 0.038219701457811 23593282 We identified vascular endothelial growth factor C VEGFC as a novel target gene of miR-27b and determined that miR-27b functioned as an inhibitor of tumor progression and angiogenesis through targeting VEGFC in CRC; In summary an anti-tumor role for miR-27b and its novel target VEGFC in vivo could lead to tumor necrosis and provide a rationale for developing miR-27b as a therapeutic agent progression colorectal cancer hsa-miR-200c-3p VLDLR 3.50132673580082 2.42716349086937e-15 -1.24679016115614 0.000599286809743815 miRNATAP -0.181156675550554 2.12066097629121e-06 NA NA NA hsa-miR-200c-3p WASF3 3.50132673580082 2.42716349086937e-15 -1.29629914639685 0.000157361069159746 miRNATAP -0.125405782043077 0.000560608863782371 NA NA NA hsa-miR-200c-3p WIPF1 3.50132673580082 2.42716349086937e-15 -1.36396473341553 1.25828143739996e-05 MirTarget;miRNATAP -0.423943530965805 5.3342529515542e-46 NA NA NA hsa-miR-200c-3p WWC3 3.50132673580082 2.42716349086937e-15 -0.363513383213509 0.0875393935590409 MirTarget;miRNATAP -0.151520683382364 4.5850235687298e-12 NA NA NA hsa-miR-200c-3p XG 3.50132673580082 2.42716349086937e-15 -0.480004516902474 0.430428286478353 MirTarget -0.162986926918824 0.0111722348707166 NA NA NA hsa-miR-200c-3p YAP1 3.50132673580082 2.42716349086937e-15 -0.819514922156015 7.72909626929227e-05 MirTarget -0.104660951992012 1.60861074970143e-06 NA NA NA hsa-miR-200c-3p ZCCHC24 3.50132673580082 2.42716349086937e-15 -2.70719377368971 1.38525107553668e-17 MirTarget;miRNATAP -0.469547451027985 6.2189554143374e-53 NA NA NA hsa-miR-200c-3p ZDHHC15 3.50132673580082 2.42716349086937e-15 -2.821890119317 1.80193983474815e-08 MirTarget -0.368797952315401 2.17957524144729e-12 NA NA NA hsa-miR-200c-3p ZEB1 3.50132673580082 2.42716349086937e-15 -2.59416392469398 4.19342616481451e-16 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.486626185857263 7.57364095800154e-58 27666124;24710933;23754305;24615544;24424572;24186205;21682933;22407310;27717206;23626803 miR 200c regulates crizotinib resistant ALK positive lung cancer cells by reversing epithelial mesenchymal transition via targeting ZEB1;miR-200c has been shown to regulate the epithelial-mesenchymal transition EMT by inhibiting ZEB1 and ZEB2 expression in breast cancer cells; This study further examined the role of miR-200c in the invasion and metastasis of breast cancer that goes beyond the regulation on ZEB1 and ZEB2 expression;Overexpression of miR-200c in SN12-PM6 and 786-0 cells was concurrent with downregulation of ZEB1 and upregulation of E-cadherin mRNA and protein; Thus our study demonstrated that miR-200c decreases the metastatic ability of renal carcinoma cells by upregulating E-cadherin through ZEB1 and that modulating the expression of miR-200c could influence Akt protein levels;MiR 200c suppresses TGF β signaling and counteracts trastuzumab resistance and metastasis by targeting ZNF217 and ZEB1 in breast cancer; MiR-200c which was the most significantly downregulated miRNA in trastuzumab-resistant cells restored trastuzumab sensitivity and suppressed invasion of breast cancer cells by concurrently targeting ZNF217 a transcriptional activator of TGF-β and ZEB1 a known mediator of TGF-β signaling; Given the reported backward inhibition of miR-200c by ZEB1 ZNF217 also exerts a feedback suppression of miR-200c via TGF-β/ZEB1 signaling; Restoration of miR-200c silencing of ZEB1 or ZNF217 or blockade of TGF-β signaling increased trastuzumab sensitivity and suppressed invasiveness of breast cancer cells;Accordingly the enforced expression of miR-200c and mir-141 resulted in a significant upregulation in E-cadherin expression contrary to the significant downregulation in ZEB1 expression in 3 cell lines UTSCC-24A UTSCC-24B and UTSCC-6A cells;Furthermore miR-200c was found to be important in modulating ZEB1 upregulation by ERG;Of this family miR-200c has garnered particular attention as a consequence of its ability to target ZEB1 and ZEB2 mediators of epithelial- mesenchymal transition;miR 200c inhibits invasion and migration in human colon cancer cells SW480/620 by targeting ZEB1; Among those dysregulated microRNAs miR-200c was speculated to inhibit metastasis by targeting ZEB1; Overexpression of miR-200c was concurrent with downregulation of ZEB1 mRNA and protein; Taken together our study demonstrated that miR-200c inhibits metastatic ability by targeting ZEB1 in colon cancer cells SW480/620 and suggested that modulation of miR-200c could serve as therapeutic tool for inhibiting metastasis in colorectal cancer;Epigenetic Silencing of miR 200c in Breast Cancer Is Associated with Aggressiveness and Is Modulated by ZEB1;Concomitant with the increase in miR-200b and miR-200c ZEB1 expression was decreased and cells appeared more epithelial in morphology and were sensitized to TAM and fulvestrant inhibition ;metastasis;;metastasis;drug resistance;;;;metastasis;; lung cancer;breast cancer;kidney renal cell cancer;breast cancer;head and neck cancer;prostate cancer;breast cancer;colon cancer;breast cancer;breast cancer hsa-miR-200c-3p ZEB2 3.50132673580082 2.42716349086937e-15 -2.26388876645177 1.13775147583663e-12 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.505461667418299 3.51768104787574e-66 24710933;26935975;21682933;25052237;18925646;24885194 miR-200c has been shown to regulate the epithelial-mesenchymal transition EMT by inhibiting ZEB1 and ZEB2 expression in breast cancer cells; This study further examined the role of miR-200c in the invasion and metastasis of breast cancer that goes beyond the regulation on ZEB1 and ZEB2 expression;MicroRNA 200c inhibits the metastasis of non small cell lung cancer cells by targeting ZEB2 an epithelial mesenchymal transition regulator;Of this family miR-200c has garnered particular attention as a consequence of its ability to target ZEB1 and ZEB2 mediators of epithelial- mesenchymal transition;miR 200c modulates ovarian cancer cell metastasis potential by targeting zinc finger E box binding homeobox 2 ZEB2 expression; Luciferase reporter assay confirmed the target of miR-200c as ZEB2; Furthermore miR-200c expression inhibited ovarian cancer cell ES-2 migration and invasion capacity by suppression of ZEB2 expression p < 0.01; Thus targeting of miR-200c or ZEB2 may serve as a potential therapeutic strategy for control of ovarian cancer;We established by quantitative RT-PCR that in CCCs in which miR-141 and miR-200c were down-regulated ZFHX1B a transcriptional repressor for CDH1/E-cadherin tended to be up-regulated; On the basis of these findings we suggest that down-regulation of miR-141 and miR-200c in CCCs might be involved in suppression of CDH1/E-cadherin transcription via up-regulation of ZFHX1B;Two gastric cancer cell lines were treated with IGF-I to induce EMT and levels of transcription factor ZEB2 and microRNA-200c miR-200c were measured; Furthermore both Akt/ERK inhibitors and knockdown of Akt/ERK gene reversed IGF-I-induced ZEB2 up-regulation and EMT through up-regulation of miR-200c suggesting the involvement of an Akt/ERK-miR-200c-ZEB2 axis in IGF-I-induced EMT metastasis;metastasis;;metastasis;; breast cancer;lung squamous cell cancer;breast cancer;ovarian cancer;kidney renal cell cancer;gastric cancer hsa-miR-200c-3p ZFHX4 3.50132673580082 2.42716349086937e-15 -2.72243653694716 1.46650038380412e-06 miRNATAP -0.601417439334846 3.8300230069112e-26 NA NA NA hsa-miR-200c-3p ZFP37 3.50132673580082 2.42716349086937e-15 -0.810062916275531 0.0701924167642926 mirMAP -0.130123457665786 0.00587641944702704 NA NA NA hsa-miR-200c-3p ZFPM2 3.50132673580082 2.42716349086937e-15 -3.29884457958359 4.34537841593148e-12 miRNAWalker2_validate;miRTarBase;miRNATAP -0.611029488221047 1.66969606835284e-38 NA NA NA hsa-miR-200c-3p ZNF280B 3.50132673580082 2.42716349086937e-15 -1.31579833605866 0.00759832510998532 mirMAP -0.223075615143802 1.67943626937628e-05 NA NA NA hsa-miR-200c-3p ZNF423 3.50132673580082 2.42716349086937e-15 -1.58042037965747 5.91645417503201e-05 MirTarget -0.120332911159474 0.00403100341741656 NA NA NA hsa-miR-200c-3p ZNF516 3.50132673580082 2.42716349086937e-15 -1.70455112707834 2.41525896684444e-07 mirMAP;miRNATAP -0.14419629195539 4.04656572140796e-05 NA NA NA hsa-miR-200c-3p ZNF532 3.50132673580082 2.42716349086937e-15 -0.642348594400126 0.00482300004408463 MirTarget;miRNATAP -0.180943492548472 9.78355396595791e-15 NA NA NA