miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-125b-5p AKT1 -1.94393269763542 2.78180543229264e-58 0.675644771423915 4.31393881321574e-23 miRNAWalker2_validate;miRTarBase -0.198341990959858 1.58124486218174e-28 NA NA NA hsa-miR-143-3p AKT1 -1.23248181631499 4.74160976678504e-28 0.675644771423915 4.31393881321574e-23 miRNAWalker2_validate -0.113351907486334 3.74647210660112e-08 NA NA NA hsa-miR-24-3p AKT2 -0.120123317289941 0.21432376743243 -0.0243409112523851 0.696831042278932 mirMAP -0.108581040434418 8.76204903485834e-07 NA NA NA hsa-miR-30e-3p AKT2 -0.708952170420973 1.05866470714978e-22 -0.0243409112523851 0.696831042278932 mirMAP -0.10769217628588 0.000202699653075448 NA NA NA hsa-miR-106b-5p AKT3 1.22477789913175 2.31787213143326e-32 -1.39153139819913 1.56022353185962e-23 miRNATAP -0.328917679851073 3.2761525214021e-13 NA NA NA hsa-miR-107 AKT3 0.678998026350662 2.56224148930538e-16 -1.39153139819913 1.56022353185962e-23 PITA;miRanda -0.322045444014362 3.05085750718847e-08 NA NA NA hsa-miR-15a-5p AKT3 0.812445324157528 4.50263417099822e-20 -1.39153139819913 1.56022353185962e-23 miRNAWalker2_validate;miRTarBase;miRNATAP -0.50537113863267 1.94212195956378e-21 NA NA NA hsa-miR-15b-5p AKT3 0.788659356634696 1.13678211092534e-11 -1.39153139819913 1.56022353185962e-23 miRNATAP -0.193152993862959 3.52162993117826e-06 NA NA NA hsa-miR-16-5p AKT3 0.46835991343556 1.91125356547776e-06 -1.39153139819913 1.56022353185962e-23 miRNAWalker2_validate;miRTarBase;miRNATAP -0.137142128931012 0.00593844300257035 NA NA NA hsa-miR-181a-5p AKT3 0.635863607630183 6.72486918157744e-11 -1.39153139819913 1.56022353185962e-23 miRNATAP -0.151700435123375 0.00241569058552761 NA NA NA hsa-miR-181b-5p AKT3 1.22749257795094 1.21998198830919e-27 -1.39153139819913 1.56022353185962e-23 miRNATAP -0.228362092376509 5.2632904676588e-08 NA NA NA hsa-miR-20a-5p AKT3 0.44979911120222 0.000602386964327228 -1.39153139819913 1.56022353185962e-23 miRNATAP -0.142287905559561 0.000137185408492637 NA NA NA hsa-miR-29b-2-5p AKT3 -0.263499971180298 0.0400001755611965 -1.39153139819913 1.56022353185962e-23 mirMAP -0.174192327083419 4.9828909918003e-06 NA NA NA hsa-miR-29b-3p AKT3 0.438847962603729 6.46722433236121e-05 -1.39153139819913 1.56022353185962e-23 miRNATAP -0.240095261108435 6.25012390753699e-08 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-29c-3p AKT3 -0.0652732378039769 0.563774115756922 -1.39153139819913 1.56022353185962e-23 miRNAWalker2_validate;miRNATAP -0.188130633733952 1.47230271027192e-05 NA NA NA hsa-miR-340-5p AKT3 1.0857159627596 4.94471062546756e-24 -1.39153139819913 1.56022353185962e-23 mirMAP -0.283834227072162 1.26866636163553e-10 NA NA NA hsa-miR-769-5p AKT3 0.564871766265874 8.16695101656941e-10 -1.39153139819913 1.56022353185962e-23 PITA;miRNATAP -0.188201328225218 0.000387633821142586 NA NA NA hsa-miR-93-5p AKT3 1.01788600209314 1.24312921618126e-21 -1.39153139819913 1.56022353185962e-23 miRNATAP -0.358774978428685 5.45504344144073e-16 NA NA NA hsa-miR-141-3p ARRB1 2.99777540204168 1.26370498493024e-78 -1.06393291402185 2.28886647765329e-23 MirTarget -0.169399514712247 7.04141832845205e-16 NA NA NA hsa-miR-146b-5p ARRB1 0.631041661167954 6.20366593452965e-08 -1.06393291402185 2.28886647765329e-23 miRanda -0.234378234308438 1.38470425775337e-13 NA NA NA hsa-miR-185-3p ARRB1 0.86591374114446 7.8790769678542e-10 -1.06393291402185 2.28886647765329e-23 MirTarget -0.166486935705204 4.27275331097731e-10 NA NA NA hsa-miR-186-5p ARRB1 -0.426987301460247 1.04129380549315e-05 -1.06393291402185 2.28886647765329e-23 miRNAWalker2_validate -0.225251438358519 5.19669948086572e-09 NA NA NA hsa-miR-200a-3p ARRB1 2.55218480823434 2.96135446816238e-51 -1.06393291402185 2.28886647765329e-23 MirTarget -0.11307553284225 5.52871088016413e-08 NA NA NA hsa-miR-324-3p ARRB1 0.404877731996915 0.000340036423920834 -1.06393291402185 2.28886647765329e-23 MirTarget -0.234248659277062 1.06664997452734e-12 NA NA NA hsa-miR-331-3p ARRB1 0.74441480542886 1.17071235477799e-07 -1.06393291402185 2.28886647765329e-23 MirTarget;miRNATAP -0.158301414680792 2.02060604835873e-09 NA NA NA hsa-miR-455-3p ARRB1 0.678392920628872 0.000327758844555877 -1.06393291402185 2.28886647765329e-23 MirTarget -0.210530348256382 6.52002953506511e-28 NA NA NA hsa-miR-671-5p ARRB1 1.55248047544015 7.7377784125886e-33 -1.06393291402185 2.28886647765329e-23 MirTarget -0.255594117563698 3.16668373323573e-20 NA NA NA hsa-miR-92a-3p ARRB1 -0.342420481092807 0.000732275969501111 -1.06393291402185 2.28886647765329e-23 miRNAWalker2_validate -0.212590274381006 8.46478321672934e-09 NA NA NA hsa-miR-98-5p ARRB1 0.656336869298973 9.03113188590466e-15 -1.06393291402185 2.28886647765329e-23 miRNAWalker2_validate -0.265039212188585 1.27014785161319e-09 NA NA NA hsa-miR-140-3p ATF2 -1.25844395244141 5.29222651039892e-33 -0.526197310314373 1.91997984112617e-07 MirTarget;PITA;miRNATAP -0.166236312082199 1.656661080244e-07 NA NA NA hsa-miR-15a-5p ATF2 0.812445324157528 4.50263417099822e-20 -0.526197310314373 1.91997984112617e-07 miRNAWalker2_validate -0.357209405082962 3.17144140577998e-21 NA NA NA hsa-miR-181a-5p ATF2 0.635863607630183 6.72486918157744e-11 -0.526197310314373 1.91997984112617e-07 mirMAP;miRNATAP -0.275655700176318 3.25056114494222e-15 NA NA NA hsa-miR-181b-5p ATF2 1.22749257795094 1.21998198830919e-27 -0.526197310314373 1.91997984112617e-07 mirMAP;miRNATAP -0.242609990251896 1.87882820169588e-16 NA NA NA hsa-miR-181c-5p ATF2 0.574847839298605 4.51287502066478e-07 -0.526197310314373 1.91997984112617e-07 mirMAP;miRNATAP -0.163465374342035 6.83965645814107e-08 NA NA NA hsa-miR-19a-3p ATF2 0.817507952171848 3.76285090469625e-08 -0.526197310314373 1.91997984112617e-07 MirTarget;miRNATAP -0.104880819897631 6.18713149818057e-06 NA NA NA hsa-miR-21-5p ATF2 2.32007501846389 3.08394781855554e-137 -0.526197310314373 1.91997984112617e-07 miRNAWalker2_validate -0.231001727277097 1.50432513865861e-13 NA NA NA hsa-miR-221-3p ATF2 -0.317970198201501 0.00910855267413448 -0.526197310314373 1.91997984112617e-07 MirTarget -0.164933797555005 6.40232509155629e-09 NA NA NA hsa-miR-26a-5p ATF2 -0.481180084102235 1.82368246174758e-10 -0.526197310314373 1.91997984112617e-07 MirTarget;miRNATAP -0.136339162056602 0.00311093260377358 NA NA NA hsa-miR-361-5p ATF2 -0.0996867547900457 0.095428250126326 -0.526197310314373 1.91997984112617e-07 miRanda -0.473542579976889 4.72282680855827e-16 NA NA NA hsa-miR-374a-5p ATF2 -0.239709888246804 0.00309819667153627 -0.526197310314373 1.91997984112617e-07 mirMAP -0.142980511322363 0.000948593180528854 NA NA NA hsa-miR-142-5p BDNF 1.16509303143593 1.96641162209073e-13 -1.60102244727579 3.13378744159785e-14 mirMAP -0.203218784089295 7.99082093515086e-06 NA NA NA hsa-miR-148a-5p BDNF 0.572692271754695 2.14306251522796e-06 -1.60102244727579 3.13378744159785e-14 mirMAP -0.397766884665729 3.21732972253681e-11 NA NA NA hsa-miR-155-5p BDNF 1.09766314984151 4.55650930885814e-15 -1.60102244727579 3.13378744159785e-14 miRNATAP -0.268404245015568 1.69880913103772e-07 NA NA NA hsa-miR-15a-5p BDNF 0.812445324157528 4.50263417099822e-20 -1.60102244727579 3.13378744159785e-14 MirTarget;miRNATAP -0.270462236614116 0.000896358870417413 26581909 MicroRNA 15a 5p suppresses cancer proliferation and division in human hepatocellular carcinoma by targeting BDNF; BDNF was then overexpressed in HepG2 and SNU-182 cells to evaluate its selective effect on miR-15a-5p in HCC modulation; MiR-15a-5p selectively and negatively regulated BDNF at both gene and protein levels in HCC cells; Forced overexpression of BDNF effectively reversed the tumor suppressive functions of miR-15a-5p on HCC proliferation and cell division in vitro; Our study demonstrated that miR-15a-5p is a tumor suppressor in HCC and its regulation is through BDNF in HCC liver cancer hsa-miR-16-5p BDNF 0.46835991343556 1.91125356547776e-06 -1.60102244727579 3.13378744159785e-14 MirTarget;miRNATAP -0.207572734514068 0.0054038108129975 NA NA NA hsa-miR-182-5p BDNF 2.36408084103818 2.60011457600281e-72 -1.60102244727579 3.13378744159785e-14 MirTarget;miRNATAP -0.234588678348713 3.99165896393269e-06 NA NA NA hsa-miR-210-3p BDNF 2.38367203491819 3.73261999106754e-22 -1.60102244727579 3.13378744159785e-14 miRNAWalker2_validate;miRTarBase -0.115495455176462 6.58638340303894e-05 NA NA NA hsa-miR-30e-5p BDNF 0.293491764699475 0.000372291967271834 -1.60102244727579 3.13378744159785e-14 miRNATAP -0.400421315846613 7.13698491153316e-06 NA NA NA hsa-miR-589-3p BDNF 0.0263457630961427 0.866577983997705 -1.60102244727579 3.13378744159785e-14 MirTarget -0.125027718317622 0.00920347953748705 NA NA NA hsa-miR-589-5p BDNF 0.367182541239722 1.67804815542873e-05 -1.60102244727579 3.13378744159785e-14 miRNATAP -0.314299850428925 0.00026517944556323 NA NA NA hsa-miR-590-3p BDNF 1.27438512890514 1.03164723481469e-23 -1.60102244727579 3.13378744159785e-14 miRanda;mirMAP;miRNATAP -0.314287602443717 7.91546458232199e-08 NA NA NA hsa-miR-7-1-3p BDNF 0.686579567507582 1.20731554448806e-07 -1.60102244727579 3.13378744159785e-14 MirTarget -0.157643440663764 0.00510952033279118 NA NA NA hsa-miR-146b-5p BRAF 0.631041661167954 6.20366593452965e-08 -0.221283775228288 0.00867803746223788 miRanda -0.110412388583119 7.02387106261161e-06 21874046;26883911;20406109;21537871 Additionally the activation of thyroid most common oncogenes RET/PTC3 and BRAF in PCCL3 cells upregulated miR-146b-5p expression;miR-146b-5p positively regulates migration and invasion of thyroid normal and tumor follicular cells independently from their original mutation either BRAF or RET/PTC through a mechanism that involves the actin cytoskeleton but not an increased capacity of matrix degradation;The miR-146b expression levels in PTCs with BRAF mutation were significantly higher than those without this mutation p < 0.0001;Among BRAF-positive tumors overexpression of miR-146b was associated with aggressive behavior suggesting that it may further refine the prognostic importance of BRAF ;;; thyroid cancer;thyroid cancer;thyroid cancer;thyroid cancer hsa-miR-199a-5p BRAF -0.314703593105081 0.00909304983051124 -0.221283775228288 0.00867803746223788 miRanda -0.11377610292301 1.89244658267459e-06 NA NA NA hsa-miR-199b-5p BRAF -1.37022396448377 3.25758057539223e-26 -0.221283775228288 0.00867803746223788 miRanda -0.103977173726598 1.44472266502555e-06 NA NA NA hsa-miR-29b-2-5p CACNA1A -0.263499971180298 0.0400001755611965 -0.0151396440243155 0.913309714170893 mirMAP -0.323015310350027 7.05293599956319e-19 NA NA NA hsa-miR-331-3p CACNA1A 0.74441480542886 1.17071235477799e-07 -0.0151396440243155 0.913309714170893 mirMAP -0.155229351275828 3.69185798351185e-06 NA NA NA hsa-miR-339-5p CACNA1A -0.211548290465418 0.0685885445822389 -0.0151396440243155 0.913309714170893 mirMAP -0.117971240950979 0.0040942067869691 NA NA NA hsa-miR-342-5p CACNA1A 1.49554286219821 1.56221300255782e-22 -0.0151396440243155 0.913309714170893 mirMAP -0.141957417667434 2.51091886948897e-06 NA NA NA hsa-miR-125a-5p CACNA1B -0.635694700253268 3.6703235721638e-11 1.04977639737129 0.000114751575534089 MirTarget;miRanda;miRNATAP -0.266362618014135 0.00592661426010657 NA NA NA hsa-miR-335-5p CACNA1B -2.61355235628987 2.6462884165886e-51 1.04977639737129 0.000114751575534089 miRNAWalker2_validate -0.167340866920994 0.000966752678690897 NA NA NA hsa-let-7a-3p CACNA1C 0.466622567891891 3.70886257943079e-07 -0.825897678032819 4.27711725647878e-10 MirTarget -0.23768074059835 1.68220008416103e-06 NA NA NA hsa-let-7f-1-3p CACNA1C 0.37532726250321 0.00156021688753682 -0.825897678032819 4.27711725647878e-10 MirTarget -0.187880705200136 1.41721808672007e-06 NA NA NA hsa-miR-107 CACNA1C 0.678998026350662 2.56224148930538e-16 -0.825897678032819 4.27711725647878e-10 miRNATAP -0.456595358277975 1.66936245094072e-17 NA NA NA hsa-miR-186-5p CACNA1C -0.426987301460247 1.04129380549315e-05 -0.825897678032819 4.27711725647878e-10 mirMAP -0.27023712609733 8.63501026971349e-09 NA NA NA hsa-miR-192-5p CACNA1C 1.33366224451777 9.5116159697107e-29 -0.825897678032819 4.27711725647878e-10 mirMAP -0.221846320829899 1.44398361538273e-09 NA NA NA hsa-miR-1976 CACNA1C 0.289190368864725 0.00167092758216584 -0.825897678032819 4.27711725647878e-10 MirTarget -0.199621017922728 6.23726897560991e-05 NA NA NA hsa-miR-19a-3p CACNA1C 0.817507952171848 3.76285090469625e-08 -0.825897678032819 4.27711725647878e-10 MirTarget -0.248485311375199 1.40425100679398e-16 NA NA NA hsa-miR-19b-1-5p CACNA1C 0.647704962003062 3.07687667945597e-07 -0.825897678032819 4.27711725647878e-10 MirTarget -0.228323772421057 1.5988850419234e-10 NA NA NA hsa-miR-19b-3p CACNA1C 0.139124391010031 0.255658553872934 -0.825897678032819 4.27711725647878e-10 MirTarget -0.252380402042717 1.03972172913245e-11 NA NA NA hsa-miR-200b-3p CACNA1C 2.11744072703209 1.66710572104191e-43 -0.825897678032819 4.27711725647878e-10 MirTarget;TargetScan -0.118126560258071 2.93890482056991e-05 NA NA NA hsa-miR-200c-3p CACNA1C 2.07038651806183 6.84613386286599e-51 -0.825897678032819 4.27711725647878e-10 MirTarget -0.177083982550756 1.05519360943015e-08 NA NA NA hsa-miR-29b-3p CACNA1C 0.438847962603729 6.46722433236121e-05 -0.825897678032819 4.27711725647878e-10 MirTarget -0.259865351375545 3.11832394073589e-10 NA NA NA hsa-miR-30d-5p CACNA1C -0.247082219011045 0.00406717930063148 -0.825897678032819 4.27711725647878e-10 mirMAP -0.14414147851522 0.0071262449699794 NA NA NA hsa-miR-30e-5p CACNA1C 0.293491764699475 0.000372291967271834 -0.825897678032819 4.27711725647878e-10 mirMAP -0.285550031794163 2.70493849552241e-07 NA NA NA hsa-miR-320b CACNA1C 0.412787504747938 0.00113457276903985 -0.825897678032819 4.27711725647878e-10 miRNATAP -0.169140677632998 2.88573573244433e-06 NA NA NA hsa-miR-330-5p CACNA1C 0.626063225953928 3.42215028606779e-09 -0.825897678032819 4.27711725647878e-10 miRanda -0.295847809581919 3.33575570685743e-12 NA NA NA hsa-miR-33a-5p CACNA1C 1.35185127289399 9.80509199125785e-12 -0.825897678032819 4.27711725647878e-10 MirTarget -0.182848245440103 1.2278223642344e-15 NA NA NA hsa-miR-342-3p CACNA1C 1.21944481975657 6.81914373001202e-19 -0.825897678032819 4.27711725647878e-10 MirTarget;PITA;miRanda;miRNATAP -0.118486033175114 0.000279535425664094 NA NA NA hsa-miR-361-3p CACNA1C -0.0370446538644886 0.624902392829872 -0.825897678032819 4.27711725647878e-10 MirTarget -0.279760591195035 4.30022587395922e-06 NA NA NA hsa-miR-429 CACNA1C 2.84108892259147 3.88520896426515e-64 -0.825897678032819 4.27711725647878e-10 MirTarget;PITA;miRanda;miRNATAP -0.158582393705344 2.56283711392604e-10 NA NA NA hsa-miR-484 CACNA1C 0.349444060004737 0.00154491249625173 -0.825897678032819 4.27711725647878e-10 PITA;miRNATAP -0.323682586577132 2.46488737085131e-15 NA NA NA hsa-miR-532-5p CACNA1C 0.0386976222860582 0.682018574136515 -0.825897678032819 4.27711725647878e-10 PITA -0.336790244194034 2.86275205432301e-12 NA NA NA hsa-miR-589-3p CACNA1C 0.0263457630961427 0.866577983997705 -0.825897678032819 4.27711725647878e-10 MirTarget;mirMAP -0.148992374274382 5.64115768176244e-07 NA NA NA hsa-miR-660-5p CACNA1C 0.406910761707485 0.000156175371762464 -0.825897678032819 4.27711725647878e-10 MirTarget -0.243781292366972 7.99435270674794e-09 NA NA NA hsa-miR-7-1-3p CACNA1C 0.686579567507582 1.20731554448806e-07 -0.825897678032819 4.27711725647878e-10 MirTarget -0.162196647273659 3.52001204749273e-06 NA NA NA hsa-miR-93-3p CACNA1C 0.627759242044891 3.62527588304617e-06 -0.825897678032819 4.27711725647878e-10 mirMAP -0.306530526498449 1.17195569542657e-20 NA NA NA hsa-miR-96-5p CACNA1C 3.24596558166606 1.92296159041707e-98 -0.825897678032819 4.27711725647878e-10 MirTarget;TargetScan -0.16303248428651 4.80189450318412e-10 NA NA NA hsa-let-7a-2-3p CACNA1D -1.30646060964956 1.05363588067753e-14 1.29741717389352 5.48962840197304e-09 MirTarget -0.200685258644728 7.95064613687094e-06 NA NA NA hsa-let-7g-3p CACNA1D 0.5854327663695 0.000371711766083627 1.29741717389352 5.48962840197304e-09 MirTarget;miRNATAP -0.153235809783822 0.00101502613973484 NA NA NA hsa-let-7g-5p CACNA1D 0.0200025784917734 0.791635298815256 1.29741717389352 5.48962840197304e-09 miRNATAP -0.27830156925647 0.00676350100343291 NA NA NA hsa-let-7i-5p CACNA1D -0.333419326258177 3.56960810786801e-08 1.29741717389352 5.48962840197304e-09 miRNATAP -1.2302458547488 7.41596698559184e-23 NA NA NA hsa-miR-142-3p CACNA1D 1.53951237846104 2.06769936282034e-17 1.29741717389352 5.48962840197304e-09 miRanda -0.243146870022136 3.77680441252497e-09 NA NA NA hsa-miR-145-5p CACNA1D -2.62703571936687 7.64402900188551e-88 1.29741717389352 5.48962840197304e-09 MirTarget;miRNATAP -0.169999006636138 0.00110885711768601 NA NA NA hsa-miR-148a-5p CACNA1D 0.572692271754695 2.14306251522796e-06 1.29741717389352 5.48962840197304e-09 MirTarget;miRNATAP -0.217923447268264 0.000588112949220923 NA NA NA hsa-miR-150-5p CACNA1D -0.832049526091211 3.45299201139224e-05 1.29741717389352 5.48962840197304e-09 MirTarget -0.251931260482449 2.3828429991798e-11 NA NA NA hsa-miR-17-3p CACNA1D 0.721439431208839 7.95900548819742e-10 1.29741717389352 5.48962840197304e-09 MirTarget;miRNATAP -0.533829693287071 6.54503530861845e-17 NA NA NA hsa-miR-326 CACNA1D -1.54449030848141 1.04703417845594e-17 1.29741717389352 5.48962840197304e-09 miRanda -0.128719988868852 0.0021007274452313 NA NA NA hsa-miR-330-5p CACNA1D 0.626063225953928 3.42215028606779e-09 1.29741717389352 5.48962840197304e-09 miRanda -0.218564074288422 0.00247419747014884 NA NA NA hsa-miR-495-3p CACNA1D -1.67685437612894 1.70634429769052e-34 1.29741717389352 5.48962840197304e-09 MirTarget -0.158818773013771 0.00332258978011207 NA NA NA hsa-miR-582-5p CACNA1D 0.201134299470983 0.149482495292227 1.29741717389352 5.48962840197304e-09 miRNATAP -0.197459158205497 0.000399522877494154 NA NA NA hsa-miR-590-3p CACNA1D 1.27438512890514 1.03164723481469e-23 1.29741717389352 5.48962840197304e-09 miRanda;miRNATAP -0.412318410908047 1.42395192187719e-11 NA NA NA hsa-let-7a-5p CACNA1E -0.210286642041636 0.0072546234707717 1.4605560700465 2.1876957327321e-14 TargetScan;miRNATAP -0.25123738870204 0.00336810425517113 NA NA NA hsa-let-7b-5p CACNA1E -0.54215483448257 7.21347617597858e-08 1.4605560700465 2.1876957327321e-14 miRNATAP -0.343897563417041 1.56890640326598e-07 NA NA NA hsa-miR-101-5p CACNA1E -0.924339097794373 3.12609538539163e-15 1.4605560700465 2.1876957327321e-14 mirMAP -0.294546929573369 1.33189837953622e-07 NA NA NA hsa-miR-125a-5p CACNA1E -0.635694700253268 3.6703235721638e-11 1.4605560700465 2.1876957327321e-14 miRanda -0.528784570867115 6.17227765744719e-15 NA NA NA hsa-miR-195-3p CACNA1E -1.49582726452416 6.53261924105147e-40 1.4605560700465 2.1876957327321e-14 mirMAP -0.315308163797935 1.61195600598951e-08 NA NA NA hsa-miR-195-5p CACNA1E -1.47508108420708 2.20685847368258e-38 1.4605560700465 2.1876957327321e-14 MirTarget -0.264839934095179 1.97124908297633e-06 NA NA NA hsa-miR-30a-3p CACNA1E -1.08956435286856 1.10750674569595e-12 1.4605560700465 2.1876957327321e-14 MirTarget;mirMAP;miRNATAP -0.19382034069223 5.84003071616823e-06 NA NA NA hsa-miR-30b-3p CACNA1E -0.536462824497982 2.41814659272548e-05 1.4605560700465 2.1876957327321e-14 mirMAP -0.265986226486925 3.71541733706038e-07 NA NA NA hsa-miR-320a CACNA1E -0.287921276129346 0.00141693637596294 1.4605560700465 2.1876957327321e-14 miRanda;miRNATAP -0.225661806905697 0.00232202314381689 NA NA NA hsa-miR-335-3p CACNA1E -1.88448538773649 2.09538234398335e-32 1.4605560700465 2.1876957327321e-14 mirMAP -0.107364673416966 0.00768303724672809 NA NA NA hsa-miR-338-3p CACNA1E 0.0799903526884966 0.575137668326679 1.4605560700465 2.1876957327321e-14 miRanda;mirMAP -0.200705286597237 1.66272725942448e-05 NA NA NA hsa-miR-365a-3p CACNA1E -1.45032725192851 2.37888098061118e-37 1.4605560700465 2.1876957327321e-14 mirMAP -0.41709566557267 4.84675259531117e-14 NA NA NA hsa-miR-497-5p CACNA1E -1.4667331575679 5.49909921822638e-36 1.4605560700465 2.1876957327321e-14 MirTarget -0.336578290578085 4.69817040567113e-10 NA NA NA hsa-miR-664a-5p CACNA1E -0.292101258420761 0.00739803623640728 1.4605560700465 2.1876957327321e-14 mirMAP -0.281701302780535 4.1868260332209e-06 NA NA NA hsa-miR-151a-3p CACNA1G 0.3530403796941 3.45015092968892e-05 -1.37568574377156 8.21308100897495e-10 MirTarget -0.492274734317043 5.7254303806427e-08 NA NA NA hsa-miR-326 CACNA1G -1.54449030848141 1.04703417845594e-17 -1.37568574377156 8.21308100897495e-10 miRanda -0.1442291544107 0.00062401573369392 NA NA NA hsa-miR-362-5p CACNA1G -0.248676340901797 0.0726089851456282 -1.37568574377156 8.21308100897495e-10 miRNATAP -0.221058233808127 7.77479925141436e-05 NA NA NA hsa-miR-590-3p CACNA1G 1.27438512890514 1.03164723481469e-23 -1.37568574377156 8.21308100897495e-10 miRanda -0.629153469381859 2.12000379452695e-25 NA NA NA hsa-miR-590-5p CACNA1G 0.746515607868274 8.51300479640125e-09 -1.37568574377156 8.21308100897495e-10 miRanda -0.641590472783762 5.97036182339086e-29 NA NA NA hsa-miR-629-3p CACNA1G 1.25035919247365 3.91361135469024e-14 -1.37568574377156 8.21308100897495e-10 MirTarget -0.552026991509045 2.61097645396351e-33 NA NA NA hsa-miR-96-5p CACNA1G 3.24596558166606 1.92296159041707e-98 -1.37568574377156 8.21308100897495e-10 TargetScan -0.431573427571995 4.13927647444552e-23 NA NA NA hsa-miR-361-3p CACNA1H -0.0370446538644886 0.624902392829872 1.2275733664474 5.57239910647907e-07 MirTarget;mirMAP -0.431509304837243 0.000127805832052856 NA NA NA hsa-miR-92a-3p CACNA1H -0.342420481092807 0.000732275969501111 1.2275733664474 5.57239910647907e-07 miRNATAP -0.690420944906455 4.06449296268774e-17 NA NA NA hsa-let-7g-3p CACNA1I 0.5854327663695 0.000371711766083627 0.620827459542368 0.00606944413887044 miRNATAP -0.135648226142051 0.00396537506850092 NA NA NA hsa-miR-324-3p CACNA1I 0.404877731996915 0.000340036423920834 0.620827459542368 0.00606944413887044 miRNAWalker2_validate;mirMAP -0.194994087143432 0.00455086053628205 NA NA NA hsa-miR-92a-3p CACNA1I -0.342420481092807 0.000732275969501111 0.620827459542368 0.00606944413887044 MirTarget;miRNATAP -0.209870878487545 0.00624668079692095 NA NA NA hsa-let-7a-3p CACNA2D1 0.466622567891891 3.70886257943079e-07 -3.13664353232148 8.51761818806015e-30 mirMAP -0.286467697689714 0.00747539259133579 NA NA NA hsa-miR-103a-3p CACNA2D1 0.610673390034345 1.63113920514646e-12 -3.13664353232148 8.51761818806015e-30 miRNATAP -1.21526913962917 9.32955230409536e-29 NA NA NA hsa-miR-107 CACNA2D1 0.678998026350662 2.56224148930538e-16 -3.13664353232148 8.51761818806015e-30 PITA;miRanda;miRNATAP -0.967605309511263 4.55718090372256e-17 NA NA NA hsa-miR-141-3p CACNA2D1 2.99777540204168 1.26370498493024e-78 -3.13664353232148 8.51761818806015e-30 TargetScan -0.686981792019036 4.96940699743537e-38 NA NA NA hsa-miR-155-5p CACNA2D1 1.09766314984151 4.55650930885814e-15 -3.13664353232148 8.51761818806015e-30 mirMAP -0.376732401198525 4.13841886665867e-08 NA NA NA hsa-miR-16-2-3p CACNA2D1 0.286355254959005 0.0256946046884474 -3.13664353232148 8.51761818806015e-30 mirMAP -0.28357821776823 0.000235151193979218 NA NA NA hsa-miR-181a-5p CACNA2D1 0.635863607630183 6.72486918157744e-11 -3.13664353232148 8.51761818806015e-30 mirMAP -0.714116420602914 5.45738350883517e-13 NA NA NA hsa-miR-181b-5p CACNA2D1 1.22749257795094 1.21998198830919e-27 -3.13664353232148 8.51761818806015e-30 mirMAP -0.776942666978216 5.71635163699034e-21 NA NA NA hsa-miR-181c-5p CACNA2D1 0.574847839298605 4.51287502066478e-07 -3.13664353232148 8.51761818806015e-30 mirMAP -0.498805170213326 5.13805667633702e-09 NA NA NA hsa-miR-182-5p CACNA2D1 2.36408084103818 2.60011457600281e-72 -3.13664353232148 8.51761818806015e-30 miRNATAP -0.50122250597948 1.08020836557635e-13 NA NA NA hsa-miR-200b-3p CACNA2D1 2.11744072703209 1.66710572104191e-43 -3.13664353232148 8.51761818806015e-30 TargetScan -0.611285006989797 4.91380566101455e-25 NA NA NA hsa-miR-21-3p CACNA2D1 2.17476065946878 5.15299442583591e-75 -3.13664353232148 8.51761818806015e-30 mirMAP -0.425146647588401 1.45632639267905e-08 NA NA NA hsa-miR-30d-3p CACNA2D1 0.264544633563642 0.00755023189129747 -3.13664353232148 8.51761818806015e-30 mirMAP -0.502922018171615 4.02129581282517e-07 NA NA NA hsa-miR-330-3p CACNA2D1 0.432728362037032 0.00041335506960812 -3.13664353232148 8.51761818806015e-30 mirMAP -0.307535804675269 0.000151899067701482 NA NA NA hsa-miR-338-3p CACNA2D1 0.0799903526884966 0.575137668326679 -3.13664353232148 8.51761818806015e-30 miRanda -0.289173396389102 2.67511810031932e-05 NA NA NA hsa-miR-590-3p CACNA2D1 1.27438512890514 1.03164723481469e-23 -3.13664353232148 8.51761818806015e-30 mirMAP -0.604759125784101 6.92397520040584e-15 NA NA NA hsa-miR-96-5p CACNA2D1 3.24596558166606 1.92296159041707e-98 -3.13664353232148 8.51761818806015e-30 TargetScan;miRNATAP -0.587322748547346 1.33430099096002e-26 NA NA NA hsa-miR-1271-5p CACNA2D2 -1.08290983583835 3.85149976357318e-12 0.520191856000968 0.0224604042502349 MirTarget -0.296566289135204 2.16815150984347e-09 NA NA NA hsa-miR-142-3p CACNA2D2 1.53951237846104 2.06769936282034e-17 0.520191856000968 0.0224604042502349 miRanda -0.315574702105467 3.4278496730612e-14 NA NA NA hsa-miR-181a-5p CACNA2D2 0.635863607630183 6.72486918157744e-11 0.520191856000968 0.0224604042502349 miRNATAP -0.36605805105881 4.00467835129977e-06 NA NA NA hsa-miR-181b-5p CACNA2D2 1.22749257795094 1.21998198830919e-27 0.520191856000968 0.0224604042502349 miRNATAP -0.388176260128488 6.11814565966903e-09 NA NA NA hsa-miR-205-5p CACNA2D2 -1.70057043266505 1.20976599540743e-09 0.520191856000968 0.0224604042502349 miRNATAP -0.114792729291005 3.09088850806225e-05 NA NA NA hsa-miR-22-5p CACNA2D2 0.238328801322329 0.0377496760295305 0.520191856000968 0.0224604042502349 mirMAP -0.539751278293511 9.49482740257468e-16 NA NA NA hsa-miR-361-3p CACNA2D2 -0.0370446538644886 0.624902392829872 0.520191856000968 0.0224604042502349 MirTarget;PITA -0.514168528646382 7.23036939758475e-07 NA NA NA hsa-miR-432-5p CACNA2D2 -1.27705834793565 1.47191322114198e-20 0.520191856000968 0.0224604042502349 mirMAP -0.185853264744759 0.000865010895036189 NA NA NA hsa-miR-455-3p CACNA2D2 0.678392920628872 0.000327758844555877 0.520191856000968 0.0224604042502349 PITA;miRNATAP -0.428864374578241 7.71596415872339e-27 NA NA NA hsa-miR-532-5p CACNA2D2 0.0386976222860582 0.682018574136515 0.520191856000968 0.0224604042502349 PITA;miRNATAP -0.934080145382912 2.55988709174463e-31 NA NA NA hsa-miR-539-5p CACNA2D2 -1.28530285996605 1.62620330363951e-14 0.520191856000968 0.0224604042502349 miRNATAP -0.154342429693703 0.000807918607303374 NA NA NA hsa-miR-582-5p CACNA2D2 0.201134299470983 0.149482495292227 0.520191856000968 0.0224604042502349 PITA;miRNATAP -0.368407328698615 5.31892572141833e-11 NA NA NA hsa-miR-590-3p CACNA2D2 1.27438512890514 1.03164723481469e-23 0.520191856000968 0.0224604042502349 miRanda -0.408180098033577 4.72369544247662e-11 NA NA NA hsa-miR-654-3p CACNA2D2 -1.20494927978695 4.07682448923698e-16 0.520191856000968 0.0224604042502349 miRNATAP -0.138474109906314 0.00763283404321654 NA NA NA hsa-miR-193a-3p CACNA2D3 0.310617999804917 0.00477640270974957 -0.594228318106601 0.00283872336537229 miRanda -0.271933378046547 1.15861428807383e-05 NA NA NA hsa-miR-429 CACNA2D3 2.84108892259147 3.88520896426515e-64 -0.594228318106601 0.00283872336537229 miRanda -0.172954610693339 4.31660482370429e-06 NA NA NA hsa-miR-590-3p CACNA2D3 1.27438512890514 1.03164723481469e-23 -0.594228318106601 0.00283872336537229 miRanda -0.286333307499272 1.49166145427565e-07 NA NA NA hsa-miR-615-3p CACNA2D3 0.659240580933614 0.000360214386152507 -0.594228318106601 0.00283872336537229 miRanda -0.169974059811725 3.80948804633589e-06 NA NA NA hsa-miR-429 CACNA2D4 2.84108892259147 3.88520896426515e-64 -0.487016307401622 1.87890750129587e-06 miRanda -0.116251771905887 1.68988958973746e-09 NA NA NA hsa-miR-125a-5p CACNB1 -0.635694700253268 3.6703235721638e-11 0.237971194965167 0.0394225044037745 PITA;mirMAP;miRNATAP -0.117573477505178 0.00406787987812899 NA NA NA hsa-miR-146b-3p CACNB2 -0.260891807886908 0.0211838235241739 -0.730656210065775 1.97395429366425e-05 miRNATAP -0.292311828355023 1.69564797031388e-08 NA NA NA hsa-miR-181a-5p CACNB2 0.635863607630183 6.72486918157744e-11 -0.730656210065775 1.97395429366425e-05 miRNATAP -0.336919435067309 1.63572245673905e-08 NA NA NA hsa-miR-181b-5p CACNB2 1.22749257795094 1.21998198830919e-27 -0.730656210065775 1.97395429366425e-05 miRNATAP -0.295387931960751 4.39515011156399e-09 NA NA NA hsa-miR-199a-5p CACNB2 -0.314703593105081 0.00909304983051124 -0.730656210065775 1.97395429366425e-05 miRanda;miRNATAP -0.12857813674804 0.00859602326510568 NA NA NA hsa-miR-199b-5p CACNB2 -1.37022396448377 3.25758057539223e-26 -0.730656210065775 1.97395429366425e-05 miRanda;miRNATAP -0.126396782465302 0.00424529254392808 NA NA NA hsa-miR-200c-5p CACNB2 1.72523090857052 4.04399802119594e-33 -0.730656210065775 1.97395429366425e-05 MirTarget;miRNATAP -0.124517472883284 0.00213097713649977 NA NA NA hsa-miR-23a-3p CACNB2 -0.217176729033818 0.00962615056202409 -0.730656210065775 1.97395429366425e-05 mirMAP -0.238017672788277 0.000753825187705407 NA NA NA hsa-miR-23b-3p CACNB2 -0.363202401123049 0.000265305319764878 -0.730656210065775 1.97395429366425e-05 mirMAP -0.254296604926363 1.68196328599892e-05 NA NA NA hsa-miR-27a-3p CACNB2 0.388496361379095 1.42373532086331e-05 -0.730656210065775 1.97395429366425e-05 MirTarget;miRNATAP -0.261226078306034 7.18692498787269e-05 NA NA NA hsa-miR-27b-3p CACNB2 -0.0796803270437447 0.410503155574393 -0.730656210065775 1.97395429366425e-05 MirTarget;miRNATAP -0.265976879621405 1.3114366695915e-05 NA NA NA hsa-miR-340-5p CACNB2 1.0857159627596 4.94471062546756e-24 -0.730656210065775 1.97395429366425e-05 miRNATAP -0.275345746218975 2.32560960905998e-07 NA NA NA hsa-miR-361-5p CACNB2 -0.0996867547900457 0.095428250126326 -0.730656210065775 1.97395429366425e-05 miRanda -0.302371290877208 0.00256840850083373 NA NA NA hsa-miR-369-3p CACNB2 0.0880848299432269 0.48519534195924 -0.730656210065775 1.97395429366425e-05 PITA -0.261114310141144 2.34498062708304e-08 NA NA NA hsa-miR-370-3p CACNB2 -0.678485107633497 3.08223718122071e-07 -0.730656210065775 1.97395429366425e-05 MirTarget -0.194930116051635 1.07273675073799e-05 NA NA NA hsa-miR-374a-5p CACNB2 -0.239709888246804 0.00309819667153627 -0.730656210065775 1.97395429366425e-05 MirTarget -0.190806091583228 0.0091709066276553 NA NA NA hsa-miR-374b-5p CACNB2 -0.466781429946153 1.17238311619116e-08 -0.730656210065775 1.97395429366425e-05 MirTarget -0.18902173986677 0.00864565828218012 NA NA NA hsa-miR-381-3p CACNB2 -1.28028930293369 1.61402949866141e-23 -0.730656210065775 1.97395429366425e-05 MirTarget -0.118432362795988 0.0082729372343986 NA NA NA hsa-miR-590-3p CACNB2 1.27438512890514 1.03164723481469e-23 -0.730656210065775 1.97395429366425e-05 mirMAP -0.193344977854738 4.10616836243959e-05 NA NA NA hsa-miR-615-3p CACNB2 0.659240580933614 0.000360214386152507 -0.730656210065775 1.97395429366425e-05 miRanda -0.221989893932224 1.67215773379731e-12 NA NA NA hsa-miR-93-3p CACNB2 0.627759242044891 3.62527588304617e-06 -0.730656210065775 1.97395429366425e-05 MirTarget;miRNATAP -0.153598663229109 0.000383484531739499 NA NA NA hsa-miR-140-3p CACNB3 -1.25844395244141 5.29222651039892e-33 1.46776600105089 1.46068987438074e-50 PITA;miRNATAP -0.309608087063313 4.051699534977e-22 NA NA NA hsa-miR-150-5p CACNB3 -0.832049526091211 3.45299201139224e-05 1.46776600105089 1.46068987438074e-50 miRNATAP -0.133908871602773 1.88025496909564e-14 NA NA NA hsa-miR-186-5p CACNB3 -0.426987301460247 1.04129380549315e-05 1.46776600105089 1.46068987438074e-50 miRNATAP -0.193187283350733 1.50543575138671e-07 NA NA NA hsa-miR-196b-5p CACNB3 -0.302231359742807 0.0833893928085868 1.46776600105089 1.46068987438074e-50 miRNAWalker2_validate -0.126384292005885 5.16183619722105e-10 NA NA NA hsa-miR-335-5p CACNB3 -2.61355235628987 2.6462884165886e-51 1.46776600105089 1.46068987438074e-50 miRNAWalker2_validate -0.149702354514404 4.8882086502149e-15 NA NA NA hsa-let-7d-5p CACNB4 0.410958462607207 6.07808182756787e-06 -1.55153828539339 8.66363537242103e-21 miRNATAP -0.356473484682481 2.27862695381485e-08 NA NA NA hsa-let-7g-3p CACNB4 0.5854327663695 0.000371711766083627 -1.55153828539339 8.66363537242103e-21 miRNATAP -0.17357491296528 8.02317287371751e-07 NA NA NA hsa-miR-107 CACNB4 0.678998026350662 2.56224148930538e-16 -1.55153828539339 8.66363537242103e-21 miRanda -0.574796115532615 3.76137508930618e-17 NA NA NA hsa-miR-155-5p CACNB4 1.09766314984151 4.55650930885814e-15 -1.55153828539339 8.66363537242103e-21 mirMAP;miRNATAP -0.169250941445408 3.42892308399245e-05 NA NA NA hsa-miR-15a-5p CACNB4 0.812445324157528 4.50263417099822e-20 -1.55153828539339 8.66363537242103e-21 miRNATAP -0.524547853479935 1.53351417197502e-16 NA NA NA hsa-miR-15b-3p CACNB4 1.12898579025388 1.18050912917317e-14 -1.55153828539339 8.66363537242103e-21 mirMAP -0.339644978690773 9.66511641236255e-19 NA NA NA hsa-miR-15b-5p CACNB4 0.788659356634696 1.13678211092534e-11 -1.55153828539339 8.66363537242103e-21 miRNATAP -0.375467581173958 1.68208248002754e-14 NA NA NA hsa-miR-16-1-3p CACNB4 1.30142784811196 2.53343713753744e-29 -1.55153828539339 8.66363537242103e-21 mirMAP -0.410360224712748 6.07859996148842e-16 NA NA NA hsa-miR-16-5p CACNB4 0.46835991343556 1.91125356547776e-06 -1.55153828539339 8.66363537242103e-21 miRNATAP -0.376905051796708 1.28916976549026e-10 NA NA NA hsa-miR-181a-5p CACNB4 0.635863607630183 6.72486918157744e-11 -1.55153828539339 8.66363537242103e-21 mirMAP -0.227669649090504 0.000123567105655215 NA NA NA hsa-miR-181b-5p CACNB4 1.22749257795094 1.21998198830919e-27 -1.55153828539339 8.66363537242103e-21 mirMAP -0.287553929399977 7.69373535029832e-09 NA NA NA hsa-miR-181c-5p CACNB4 0.574847839298605 4.51287502066478e-07 -1.55153828539339 8.66363537242103e-21 mirMAP -0.231503089233447 5.15098254577036e-06 NA NA NA hsa-miR-182-5p CACNB4 2.36408084103818 2.60011457600281e-72 -1.55153828539339 8.66363537242103e-21 miRNATAP -0.160616053986078 7.11532513599297e-05 NA NA NA hsa-miR-183-5p CACNB4 2.95681814393872 1.09965777344285e-92 -1.55153828539339 8.66363537242103e-21 miRNATAP -0.239521601010266 1.40564551535371e-11 NA NA NA hsa-miR-221-3p CACNB4 -0.317970198201501 0.00910855267413448 -1.55153828539339 8.66363537242103e-21 miRNATAP -0.134405182841756 0.0049836032896013 NA NA NA hsa-miR-25-3p CACNB4 -0.00546790775985073 0.944061771389468 -1.55153828539339 8.66363537242103e-21 mirMAP -0.374971070329035 6.09807378546358e-07 NA NA NA hsa-miR-30e-5p CACNB4 0.293491764699475 0.000372291967271834 -1.55153828539339 8.66363537242103e-21 mirMAP -0.195274145348511 0.00598434412603084 NA NA NA hsa-miR-32-5p CACNB4 1.38676603945192 2.29428299685976e-34 -1.55153828539339 8.66363537242103e-21 mirMAP -0.302572293583101 6.32822909633069e-10 NA NA NA hsa-miR-320b CACNB4 0.412787504747938 0.00113457276903985 -1.55153828539339 8.66363537242103e-21 PITA;miRanda -0.206767989256463 7.02950279283953e-06 NA NA NA hsa-miR-330-3p CACNB4 0.432728362037032 0.00041335506960812 -1.55153828539339 8.66363537242103e-21 mirMAP -0.171477653161448 0.000366794186952017 NA NA NA hsa-miR-338-3p CACNB4 0.0799903526884966 0.575137668326679 -1.55153828539339 8.66363537242103e-21 PITA;miRanda;miRNATAP -0.163564772832202 6.14807345725303e-05 NA NA NA hsa-miR-340-5p CACNB4 1.0857159627596 4.94471062546756e-24 -1.55153828539339 8.66363537242103e-21 mirMAP -0.162404592210826 0.00215131143445412 NA NA NA hsa-miR-429 CACNB4 2.84108892259147 3.88520896426515e-64 -1.55153828539339 8.66363537242103e-21 PITA;miRanda;miRNATAP -0.218364425149989 7.04069249222511e-12 NA NA NA hsa-miR-455-5p CACNB4 0.284641224662773 0.0357572339594277 -1.55153828539339 8.66363537242103e-21 PITA;miRanda;miRNATAP -0.213153704977884 6.55962418213265e-07 NA NA NA hsa-miR-505-3p CACNB4 -0.530462599544864 7.71645736541597e-05 -1.55153828539339 8.66363537242103e-21 miRNATAP -0.169371643058834 8.97947893276895e-05 NA NA NA hsa-miR-532-5p CACNB4 0.0386976222860582 0.682018574136515 -1.55153828539339 8.66363537242103e-21 miRNATAP -0.29908699598404 1.30988421619076e-06 NA NA NA hsa-miR-590-3p CACNB4 1.27438512890514 1.03164723481469e-23 -1.55153828539339 8.66363537242103e-21 miRanda;mirMAP;miRNATAP -0.322100793327516 3.07723041503642e-12 NA NA NA hsa-miR-708-3p CACNB4 0.478640655706813 2.13865852505288e-05 -1.55153828539339 8.66363537242103e-21 mirMAP -0.144297187299673 0.00524191730109406 NA NA NA hsa-miR-92a-3p CACNB4 -0.342420481092807 0.000732275969501111 -1.55153828539339 8.66363537242103e-21 mirMAP -0.310043051991962 6.05725375318814e-08 NA NA NA hsa-miR-92b-3p CACNB4 1.30248132773644 9.42428674470985e-25 -1.55153828539339 8.66363537242103e-21 mirMAP -0.331548974356554 5.28939816843406e-14 NA NA NA hsa-miR-96-5p CACNB4 3.24596558166606 1.92296159041707e-98 -1.55153828539339 8.66363537242103e-21 TargetScan;miRNATAP -0.22030994152209 3.5598621080731e-11 NA NA NA hsa-miR-491-5p CACNG1 -1.04307210952796 1.14586501470398e-15 1.8711950939276 2.7149648014842e-09 miRanda -0.238801118409132 0.00394330910337491 NA NA NA hsa-miR-590-5p CACNG1 0.746515607868274 8.51300479640125e-09 1.8711950939276 2.7149648014842e-09 miRanda -0.525395340259112 2.05314146340077e-10 NA NA NA hsa-let-7f-1-3p CACNG4 0.37532726250321 0.00156021688753682 2.21159891256783 3.76360584804154e-13 MirTarget -0.237800583538535 0.00860722377400527 NA NA NA hsa-let-7i-5p CACNG4 -0.333419326258177 3.56960810786801e-08 2.21159891256783 3.76360584804154e-13 miRNATAP -0.806195689887048 4.56780275024607e-06 NA NA NA hsa-miR-186-5p CACNG4 -0.426987301460247 1.04129380549315e-05 2.21159891256783 3.76360584804154e-13 mirMAP -1.0085863621128 3.57675304447423e-21 NA NA NA hsa-miR-18a-5p CACNG4 0.969066793715868 1.69069796425892e-08 2.21159891256783 3.76360584804154e-13 mirMAP -0.479660977852052 1.65065818706956e-15 NA NA NA hsa-miR-28-5p CACNG4 -0.14267073663385 0.0497619246260571 2.21159891256783 3.76360584804154e-13 miRanda -0.632449765922558 1.63314781237986e-05 NA NA NA hsa-miR-29a-3p CACNG4 -0.699539666833076 1.13935003139957e-13 2.21159891256783 3.76360584804154e-13 miRNATAP -0.519431319019904 2.77239408127337e-06 NA NA NA hsa-miR-29b-3p CACNG4 0.438847962603729 6.46722433236121e-05 2.21159891256783 3.76360584804154e-13 miRNATAP -0.30385862718963 0.00160635010734061 NA NA NA hsa-miR-335-5p CACNG4 -2.61355235628987 2.6462884165886e-51 2.21159891256783 3.76360584804154e-13 miRNAWalker2_validate;mirMAP -0.148521805566539 0.00971039985566161 NA NA NA hsa-miR-582-3p CACNG4 0.126152488945932 0.333088461939587 2.21159891256783 3.76360584804154e-13 miRNATAP -0.297057041596848 0.000259299774288824 NA NA NA hsa-miR-590-3p CACNG4 1.27438512890514 1.03164723481469e-23 2.21159891256783 3.76360584804154e-13 miRanda -0.261553367118529 0.00206354560188718 NA NA NA hsa-let-7a-5p CASP3 -0.210286642041636 0.0072546234707717 0.666045797044402 6.39452182888629e-31 miRNAWalker2_validate;MirTarget;TargetScan;miRNATAP -0.195644898270621 4.6747877969906e-14 NA NA NA hsa-let-7b-5p CASP3 -0.54215483448257 7.21347617597858e-08 0.666045797044402 6.39452182888629e-31 MirTarget;miRNATAP -0.135377392684109 1.39837315047849e-11 NA NA NA hsa-let-7c-5p CASP3 -1.9415540533505 9.55250745007793e-48 0.666045797044402 6.39452182888629e-31 MirTarget -0.131994349405243 7.44021418353714e-21 NA NA NA hsa-miR-101-3p CASP3 -0.126035286271986 0.145997832808138 0.666045797044402 6.39452182888629e-31 MirTarget -0.205647208491522 1.01890278591706e-18 NA NA NA hsa-miR-139-5p CASP3 -3.25846663863766 2.62018989415003e-112 0.666045797044402 6.39452182888629e-31 miRanda -0.133754697836399 1.82907069570434e-29 NA NA NA hsa-miR-195-3p CASP3 -1.49582726452416 6.53261924105147e-40 0.666045797044402 6.39452182888629e-31 MirTarget -0.161373451028419 9.65654022351954e-22 NA NA NA hsa-miR-30a-5p CASP3 -0.392489994825279 0.00954894667761676 0.666045797044402 6.39452182888629e-31 miRNATAP -0.146653827176832 2.4661703600601e-29 NA NA NA hsa-miR-30c-5p CASP3 -0.393222674580066 8.06961465717306e-05 0.666045797044402 6.39452182888629e-31 miRNATAP -0.111784978428745 4.21945016044375e-08 NA NA NA hsa-let-7a-5p CDC25B -0.210286642041636 0.0072546234707717 0.886543805261515 7.65591725785136e-15 miRNAWalker2_validate -0.431940489849114 7.06528609848609e-18 NA NA NA hsa-miR-26b-5p CDC25B -0.331527896896866 0.000551258576575092 0.886543805261515 7.65591725785136e-15 miRNAWalker2_validate -0.109974098209589 0.00808270963890976 NA NA NA hsa-miR-361-5p CDC42 -0.0996867547900457 0.095428250126326 0.173789856138974 9.56157991686127e-05 miRanda -0.123274419160974 1.83111084046675e-06 NA NA NA hsa-miR-15a-5p CHUK 0.812445324157528 4.50263417099822e-20 -0.0655383466936339 0.252025603609673 miRNAWalker2_validate;miRTarBase;MirTarget -0.135155500445723 3.1799004977298e-10 NA NA NA hsa-miR-106b-5p CRK 1.22477789913175 2.31787213143326e-32 -0.64575500517913 2.67214525485761e-24 MirTarget;miRNATAP -0.194767338857783 1.07319106731581e-21 NA NA NA hsa-miR-146b-5p CRK 0.631041661167954 6.20366593452965e-08 -0.64575500517913 2.67214525485761e-24 MirTarget -0.135759100302402 5.74316897923704e-13 NA NA NA hsa-miR-20a-5p CRK 0.44979911120222 0.000602386964327228 -0.64575500517913 2.67214525485761e-24 MirTarget;miRNATAP -0.122410695990798 3.33057644676874e-13 NA NA NA hsa-miR-361-5p CRK -0.0996867547900457 0.095428250126326 -0.64575500517913 2.67214525485761e-24 miRanda;mirMAP -0.285260704357054 2.82489326858884e-14 NA NA NA hsa-miR-374a-5p CRK -0.239709888246804 0.00309819667153627 -0.64575500517913 2.67214525485761e-24 mirMAP -0.125606336516347 5.63446649866704e-06 NA NA NA hsa-miR-93-5p CRK 1.01788600209314 1.24312921618126e-21 -0.64575500517913 2.67214525485761e-24 MirTarget;miRNATAP -0.159898864219448 2.46288879800237e-15 NA NA NA hsa-let-7g-5p DUSP1 0.0200025784917734 0.791635298815256 -2.09516763518402 5.67014496179034e-44 miRNATAP -0.246297672689931 0.000710764303222867 NA NA NA hsa-miR-141-3p DUSP1 2.99777540204168 1.26370498493024e-78 -2.09516763518402 5.67014496179034e-44 TargetScan -0.440500474854258 4.67394231028638e-52 NA NA NA hsa-miR-148a-3p DUSP1 0.706969798912638 5.52538085480485e-09 -2.09516763518402 5.67014496179034e-44 miRNATAP -0.37123829571265 2.57636448853645e-17 NA NA NA hsa-miR-186-5p DUSP1 -0.426987301460247 1.04129380549315e-05 -2.09516763518402 5.67014496179034e-44 mirMAP -0.207057393048969 0.000231729479931182 NA NA NA hsa-miR-200b-3p DUSP1 2.11744072703209 1.66710572104191e-43 -2.09516763518402 5.67014496179034e-44 MirTarget;TargetScan -0.374890795121428 1.11762164968543e-30 NA NA NA hsa-miR-200c-3p DUSP1 2.07038651806183 6.84613386286599e-51 -2.09516763518402 5.67014496179034e-44 MirTarget;miRNATAP -0.461418642771936 8.7350380053437e-39 NA NA NA hsa-miR-324-3p DUSP1 0.404877731996915 0.000340036423920834 -2.09516763518402 5.67014496179034e-44 MirTarget -0.513444502845107 4.22374955560465e-28 NA NA NA hsa-miR-331-5p DUSP1 0.682437632502949 4.10871642662371e-11 -2.09516763518402 5.67014496179034e-44 PITA;miRNATAP -0.469067201437578 6.76654396280139e-20 NA NA NA hsa-miR-425-3p DUSP1 0.748638310915183 3.35875635079574e-11 -2.09516763518402 5.67014496179034e-44 MirTarget -0.398927925643984 2.06133886807476e-17 NA NA NA hsa-miR-429 DUSP1 2.84108892259147 3.88520896426515e-64 -2.09516763518402 5.67014496179034e-44 MirTarget;PITA;miRanda;miRNATAP -0.372780864262415 2.28853225919904e-38 NA NA NA hsa-miR-186-5p DUSP10 -0.426987301460247 1.04129380549315e-05 0.0751042476673573 0.518967701012418 mirMAP -0.121616747654674 0.00312603552439163 NA NA NA hsa-miR-25-3p DUSP10 -0.00546790775985073 0.944061771389468 0.0751042476673573 0.518967701012418 MirTarget;miRNATAP -0.171167024444357 0.000914403628865271 NA NA NA hsa-miR-92a-3p DUSP10 -0.342420481092807 0.000732275969501111 0.0751042476673573 0.518967701012418 MirTarget;miRNATAP -0.232593692029626 2.63872566908125e-09 24332650 DUSP10 is responsible for miR-92a induced JNK signalling and cell proliferation pancreatic cancer hsa-miR-98-5p DUSP10 0.656336869298973 9.03113188590466e-15 0.0751042476673573 0.518967701012418 miRNAWalker2_validate -0.190857555005881 4.07346673768446e-05 NA NA NA hsa-let-7d-5p DUSP16 0.410958462607207 6.07808182756787e-06 -0.00309802634061906 0.972233283825713 miRNATAP -0.160804506818637 1.46996434249487e-06 NA NA NA hsa-let-7i-5p DUSP16 -0.333419326258177 3.56960810786801e-08 -0.00309802634061906 0.972233283825713 miRNATAP -0.291284572337423 7.38521602227816e-09 NA NA NA hsa-miR-125a-3p DUSP16 -0.176412960953959 0.10108079286419 -0.00309802634061906 0.972233283825713 miRanda -0.135536777135669 1.72546820764117e-06 NA NA NA hsa-miR-140-5p DUSP16 -0.755971041589807 9.68060922934542e-14 -0.00309802634061906 0.972233283825713 miRNATAP -0.169799719646446 7.99001714099057e-09 NA NA NA hsa-miR-361-5p DUSP16 -0.0996867547900457 0.095428250126326 -0.00309802634061906 0.972233283825713 miRanda -0.448437407979716 1.01914609061645e-18 NA NA NA hsa-miR-374a-3p DUSP16 0.34122393953022 2.28714105382856e-05 -0.00309802634061906 0.972233283825713 mirMAP -0.121561570004941 0.00134338923676851 NA NA NA hsa-miR-342-3p DUSP22 1.21944481975657 6.81914373001202e-19 -0.773518937744533 4.22966569757524e-36 miRanda -0.125547682347853 4.58737162646531e-16 NA NA NA hsa-miR-96-5p DUSP22 3.24596558166606 1.92296159041707e-98 -0.773518937744533 4.22966569757524e-36 TargetScan -0.120897910850384 1.88401790769886e-22 NA NA NA hsa-miR-141-3p DUSP3 2.99777540204168 1.26370498493024e-78 -0.527416845652245 2.0194487779533e-21 MirTarget;TargetScan;miRNATAP -0.119241384977083 5.00857115800078e-29 NA NA NA hsa-miR-3913-5p DUSP3 0.71890413546147 2.61153227160465e-13 -0.527416845652245 2.0194487779533e-21 MirTarget -0.123719647296765 1.97437439670673e-10 NA NA NA hsa-let-7g-5p DUSP4 0.0200025784917734 0.791635298815256 -0.0640801861695559 0.746957922486221 miRNATAP -0.438120852251272 1.25131251110546e-06 NA NA NA hsa-let-7i-5p DUSP4 -0.333419326258177 3.56960810786801e-08 -0.0640801861695559 0.746957922486221 miRNATAP -0.711831573120273 2.3299595313391e-10 NA NA NA hsa-miR-136-5p DUSP4 0.0557692528524285 0.703264372780941 -0.0640801861695559 0.746957922486221 mirMAP -0.132157750762097 0.00453750076082347 NA NA NA hsa-miR-185-5p DUSP4 0.482334746589337 3.68475879959415e-09 -0.0640801861695559 0.746957922486221 MirTarget -0.429961097593508 1.92389041356864e-07 NA NA NA hsa-miR-193a-3p DUSP4 0.310617999804917 0.00477640270974957 -0.0640801861695559 0.746957922486221 mirMAP -0.285358268482688 3.6914172133754e-06 NA NA NA hsa-miR-193b-3p DUSP4 -0.0550374855074773 0.65382485898551 -0.0640801861695559 0.746957922486221 mirMAP -0.313549591454369 1.33931913656912e-08 NA NA NA hsa-miR-23a-3p DUSP4 -0.217176729033818 0.00962615056202409 -0.0640801861695559 0.746957922486221 mirMAP -0.574843706633431 9.76376881578124e-13 NA NA NA hsa-miR-23b-3p DUSP4 -0.363202401123049 0.000265305319764878 -0.0640801861695559 0.746957922486221 mirMAP -0.401450516993045 3.30380842761377e-09 NA NA NA hsa-miR-26b-3p DUSP4 -0.62588114643887 3.30712936204727e-06 -0.0640801861695559 0.746957922486221 mirMAP -0.133771558661218 0.00792927763232393 NA NA NA hsa-miR-29b-1-5p DUSP4 0.0164831140865254 0.909727358526678 -0.0640801861695559 0.746957922486221 mirMAP -0.138064484877667 0.00338174033738499 NA NA NA hsa-miR-30b-3p DUSP4 -0.536462824497982 2.41814659272548e-05 -0.0640801861695559 0.746957922486221 MirTarget -0.269586086555162 4.54742300569889e-07 NA NA NA hsa-miR-320b DUSP4 0.412787504747938 0.00113457276903985 -0.0640801861695559 0.746957922486221 PITA;miRanda;mirMAP -0.249556111676658 3.3372326722629e-06 NA NA NA hsa-miR-452-5p DUSP4 -2.48486455572568 1.24430987974325e-33 -0.0640801861695559 0.746957922486221 mirMAP -0.168546342430895 8.96343246877319e-08 NA NA NA hsa-miR-589-3p DUSP4 0.0263457630961427 0.866577983997705 -0.0640801861695559 0.746957922486221 mirMAP -0.259107924308665 4.19577656489378e-09 NA NA NA hsa-miR-590-3p DUSP4 1.27438512890514 1.03164723481469e-23 -0.0640801861695559 0.746957922486221 mirMAP -0.406582668923767 3.93394793269308e-14 NA NA NA hsa-miR-628-5p DUSP4 0.107482129280898 0.569748271582925 -0.0640801861695559 0.746957922486221 mirMAP -0.117721300556605 0.0010593357150172 NA NA NA hsa-miR-181b-5p DUSP5 1.22749257795094 1.21998198830919e-27 0.414112199348983 0.000808154115185925 miRNATAP -0.11072139322231 0.00243615525830258 NA NA NA hsa-miR-23a-3p DUSP5 -0.217176729033818 0.00962615056202409 0.414112199348983 0.000808154115185925 MirTarget;miRNATAP -0.380526496637486 3.45923564555459e-14 NA NA NA hsa-miR-23b-3p DUSP5 -0.363202401123049 0.000265305319764878 0.414112199348983 0.000808154115185925 MirTarget;miRNATAP -0.202690682001753 1.86292773257031e-06 NA NA NA hsa-miR-25-3p DUSP5 -0.00546790775985073 0.944061771389468 0.414112199348983 0.000808154115185925 MirTarget;miRNATAP -0.297074388815999 5.5452015904367e-08 NA NA NA hsa-miR-27a-3p DUSP5 0.388496361379095 1.42373532086331e-05 0.414112199348983 0.000808154115185925 miRNAWalker2_validate;miRNATAP -0.330054031946048 2.02275713053923e-12 NA NA NA hsa-miR-27b-3p DUSP5 -0.0796803270437447 0.410503155574393 0.414112199348983 0.000808154115185925 miRNAWalker2_validate;miRNATAP -0.22412416863783 3.23990727508526e-07 NA NA NA hsa-miR-324-5p DUSP5 0.211552647440779 0.139408130311654 0.414112199348983 0.000808154115185925 miRanda -0.200619402388931 8.33547620535916e-12 NA NA NA hsa-miR-590-5p DUSP5 0.746515607868274 8.51300479640125e-09 0.414112199348983 0.000808154115185925 PITA;miRanda;miRNATAP -0.226087216837393 2.00060203715214e-12 NA NA NA hsa-miR-92a-3p DUSP5 -0.342420481092807 0.000732275969501111 0.414112199348983 0.000808154115185925 MirTarget;miRNATAP -0.32936888689028 1.45544693715002e-15 NA NA NA hsa-miR-342-3p DUSP6 1.21944481975657 6.81914373001202e-19 -1.66407181311899 8.17228231309969e-41 PITA;miRanda -0.222339440435746 1.94431655220102e-12 NA NA NA hsa-miR-590-3p DUSP6 1.27438512890514 1.03164723481469e-23 -1.66407181311899 8.17228231309969e-41 PITA;miRanda;mirMAP -0.246149773662277 4.37177854970617e-12 NA NA NA hsa-miR-29c-3p DUSP7 -0.0652732378039769 0.563774115756922 -0.391669761231966 3.14415555786095e-09 mirMAP -0.145599622244029 3.33943490476462e-13 NA NA NA hsa-miR-342-3p DUSP7 1.21944481975657 6.81914373001202e-19 -0.391669761231966 3.14415555786095e-09 mirMAP -0.152777046688625 6.44852776381819e-22 NA NA NA hsa-miR-130b-3p DUSP8 1.38122163823846 1.00932179737836e-26 -0.0861015997642132 0.460259030583654 miRNAWalker2_validate -0.113894305224814 0.000154851554945599 NA NA NA hsa-miR-186-5p DUSP8 -0.426987301460247 1.04129380549315e-05 -0.0861015997642132 0.460259030583654 miRNAWalker2_validate -0.137622425552037 0.000831981876759652 NA NA NA hsa-miR-24-3p DUSP8 -0.120123317289941 0.21432376743243 -0.0861015997642132 0.460259030583654 MirTarget;miRNATAP -0.233275790415313 1.49340227132337e-08 NA NA NA hsa-miR-30e-3p DUSP8 -0.708952170420973 1.05866470714978e-22 -0.0861015997642132 0.460259030583654 MirTarget -0.258171013235441 1.79167656733558e-06 NA NA NA hsa-miR-374b-5p DUSP8 -0.466781429946153 1.17238311619116e-08 -0.0861015997642132 0.460259030583654 MirTarget;miRNATAP -0.145088629267518 0.00290476839038099 NA NA NA hsa-miR-505-5p DUSP8 -0.842640534241897 4.43022473091907e-09 -0.0861015997642132 0.460259030583654 mirMAP -0.102307941973792 0.000210825392292539 NA NA NA hsa-let-7a-5p DUSP9 -0.210286642041636 0.0072546234707717 -0.136517617593393 0.640584048605586 TargetScan;miRNATAP -0.926120717665059 3.28471212802163e-13 NA NA NA hsa-let-7b-5p DUSP9 -0.54215483448257 7.21347617597858e-08 -0.136517617593393 0.640584048605586 miRNATAP -0.6899905956995 1.88109897764507e-12 NA NA NA hsa-miR-30a-3p DUSP9 -1.08956435286856 1.10750674569595e-12 -0.136517617593393 0.640584048605586 MirTarget -0.469681581632371 1.62179951925266e-13 NA NA NA hsa-miR-338-3p DUSP9 0.0799903526884966 0.575137668326679 -0.136517617593393 0.640584048605586 mirMAP -0.226688265130853 0.00125302346223235 NA NA NA hsa-miR-142-3p ECSIT 1.53951237846104 2.06769936282034e-17 0.0614886872007059 0.445514358148401 miRanda -0.101181824994462 6.33982764733079e-12 NA NA NA hsa-miR-590-3p EGF 1.27438512890514 1.03164723481469e-23 -1.56299913658955 5.86935289521553e-09 miRanda -0.381992230343087 2.5216093989528e-07 NA NA NA hsa-miR-629-3p EGF 1.25035919247365 3.91361135469024e-14 -1.56299913658955 5.86935289521553e-09 miRNATAP -0.198651351598521 0.000506937207678382 NA NA NA hsa-miR-107 EGFR 0.678998026350662 2.56224148930538e-16 -3.35228711557446 2.81857446737209e-45 miRanda -0.619981893208437 1.16509488926421e-09 NA NA NA hsa-miR-128-3p EGFR 0.90296715955238 9.925204823863e-23 -3.35228711557446 2.81857446737209e-45 miRNAWalker2_validate;miRTarBase -0.403877837900024 9.67805623106623e-06 NA NA NA hsa-miR-141-3p EGFR 2.99777540204168 1.26370498493024e-78 -3.35228711557446 2.81857446737209e-45 MirTarget -0.586858650420638 4.17631860777935e-36 26025929 Treatment with the EGFR inhibitor AG1478 or overexpression of miR141 blocked the activity of ERK downstream of EGFR and inhibited KLF8-depndent cell invasiveness proliferation and viability in cell culture and invasive growth and lung metastasis in nude mice metastasis breast cancer hsa-miR-141-5p EGFR 2.38411349683216 4.56310582620282e-58 -3.35228711557446 2.81857446737209e-45 MirTarget -0.540232230964423 7.07290618976338e-25 26025929 Treatment with the EGFR inhibitor AG1478 or overexpression of miR141 blocked the activity of ERK downstream of EGFR and inhibited KLF8-depndent cell invasiveness proliferation and viability in cell culture and invasive growth and lung metastasis in nude mice metastasis breast cancer hsa-miR-192-5p EGFR 1.33366224451777 9.5116159697107e-29 -3.35228711557446 2.81857446737209e-45 mirMAP -0.290600739714254 2.7733146554232e-05 NA NA NA hsa-miR-200a-3p EGFR 2.55218480823434 2.96135446816238e-51 -3.35228711557446 2.81857446737209e-45 MirTarget -0.529702964197266 2.19864859009139e-30 26184032;19671845 MicroRNA 200a Targets EGFR and c Met to Inhibit Migration Invasion and Gefitinib Resistance in Non Small Cell Lung Cancer; In this study we found that miR-200a is downregulated in NSCLC cells where it directly targets the 3'-UTR of both EGFR and c-Met mRNA; Overexpression of miR-200a in NSCLC cells significantly downregulates both EGFR and c-Met levels and severely inhibits cell migration and invasion;Protein expression and signaling pathway modulation as well as intracellular distribution of EGFR and ERRFI-1 were validated through Western blot analysis and confocal microscopy whereas ERRFI-1 direct target of miR-200 members was validated by using the wild-type and mutant 3'-untranslated region/ERRFI-1/luciferse reporters; We identified a tight association between the expression of miRNAs of the miR-200 family epithelial phenotype and sensitivity to EGFR inhibitors-induced growth inhibition in bladder carcinoma cell lines; The changes in EGFR sensitivity by silencing or forced expression of ERRFI-1 or by miR-200 expression have also been validated in additional cell lines UMUC5 and T24; Members of the miR-200 family appear to control the EMT process and sensitivity to EGFR therapy in bladder cancer cells and the expression of miR-200 is sufficient to restore EGFR dependency at least in some of the mesenchymal bladder cancer cells drug resistance;cell migration; lung squamous cell cancer;bladder cancer hsa-miR-21-5p EGFR 2.32007501846389 3.08394781855554e-137 -3.35228711557446 2.81857446737209e-45 miRNAWalker2_validate;miRTarBase -0.671030468978973 2.34536849626451e-18 24198203;20113523;24012640;24331411;26563758;19597153;26026961;20048743 In radically resected NSCLC patients the expression levels of miR-21 10b in patients with EGFR mutation were much higher than those without mutation;Thus the miR-21 inhibitor might interrupt the activity of EGFR pathways independently of PTEN status;Further the expression of miR-21 is regulated by EGFR via the activation of β-catenin and AP-1; These data indicate that a feedback loop exists between miR-21 and EGFR; These results clarify a novel association between miR-21 and EGFR in the regulation of cancer cell progression;MiR 21 overexpression is associated with acquired resistance of EGFR TKI in non small cell lung cancer;Higher expression levels of miR-21 AmiR-27a and miR-218 detected in this study suggest potential roles of these miRNAs in primary resistance to EGFR-TKI in advanced NSCLC patients with EGFR exon 19 deletion mutations;MiR 21 is an EGFR regulated anti apoptotic factor in lung cancer in never smokers; The changes in expression of some of these miRNAs including miR-21 were more remarkable in cases with EGFR mutations than in those without these mutations; In the never-smoker-derived lung adenocarcinoma cell line H3255 with mutant EGFR and high levels of p-EGFR and miR-21 antisense inhibition of miR-21 enhanced AG1478-induced apoptosis; In a never-smoker-derived adenocarcinoma cell line H441 with wild-type EGFR the antisense miR-21 not only showed the additive effect with AG1478 but also induced apoptosis by itself; These results suggest that aberrantly increased expression of miR-21 which is enhanced further by the activated EGFR signaling pathway plays a significant role in lung carcinogenesis in never-smokers as well as in smokers and is a potential therapeutic target in both EGFR-mutant and wild-type cases;Nickel may contribute to EGFR mutation and synergistically promotes tumor invasion in EGFR mutated lung cancer via nickel induced microRNA 21 expression;Downregulation of miR 21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status ;;progression;drug resistance;staging;drug resistance;tumorigenesis;; lung squamous cell cancer;glioblastoma;glioblastoma;lung squamous cell cancer;lung squamous cell cancer;lung cancer;lung cancer;glioblastoma hsa-miR-29b-2-5p EGFR -0.263499971180298 0.0400001755611965 -3.35228711557446 2.81857446737209e-45 mirMAP -0.64036074154032 1.49079407610376e-22 NA NA NA hsa-miR-30a-5p EGFR -0.392489994825279 0.00954894667761676 -3.35228711557446 2.81857446737209e-45 miRNAWalker2_validate -0.182034532010776 0.0013553693971936 NA NA NA hsa-miR-340-5p EGFR 1.0857159627596 4.94471062546756e-24 -3.35228711557446 2.81857446737209e-45 mirMAP -0.347908635889104 8.12198670456393e-06 NA NA NA hsa-miR-342-3p EGFR 1.21944481975657 6.81914373001202e-19 -3.35228711557446 2.81857446737209e-45 miRanda -0.737335841516313 4.52090989396721e-36 NA NA NA hsa-miR-375 EGFR 2.09893673049766 1.68351780396203e-16 -3.35228711557446 2.81857446737209e-45 miRanda -0.424868499428666 2.03176717536657e-41 NA NA NA hsa-miR-3913-5p EGFR 0.71890413546147 2.61153227160465e-13 -3.35228711557446 2.81857446737209e-45 mirMAP -0.573576131982504 2.54015647019285e-11 NA NA NA hsa-miR-590-3p EGFR 1.27438512890514 1.03164723481469e-23 -3.35228711557446 2.81857446737209e-45 mirMAP -0.178661531450736 0.00972280347923564 NA NA NA hsa-miR-7-1-3p EGFR 0.686579567507582 1.20731554448806e-07 -3.35228711557446 2.81857446737209e-45 mirMAP -0.355654663689424 5.93286075856605e-08 NA NA NA hsa-miR-769-5p EGFR 0.564871766265874 8.16695101656941e-10 -3.35228711557446 2.81857446737209e-45 mirMAP -0.281258757298563 0.00254804504969195 NA NA NA hsa-miR-107 ELK4 0.678998026350662 2.56224148930538e-16 -0.295067420379196 0.00481351425113707 miRNATAP -0.116968927140669 0.00632390151098228 NA NA NA hsa-miR-181a-5p ELK4 0.635863607630183 6.72486918157744e-11 -0.295067420379196 0.00481351425113707 mirMAP -0.151067838548123 3.49540655160677e-05 NA NA NA hsa-miR-181b-5p ELK4 1.22749257795094 1.21998198830919e-27 -0.295067420379196 0.00481351425113707 mirMAP -0.105841098010704 0.000605461541433292 NA NA NA hsa-miR-181c-5p ELK4 0.574847839298605 4.51287502066478e-07 -0.295067420379196 0.00481351425113707 mirMAP -0.133640922148853 1.96205500954828e-05 NA NA NA hsa-miR-361-5p ELK4 -0.0996867547900457 0.095428250126326 -0.295067420379196 0.00481351425113707 miRanda;mirMAP -0.343834175310923 1.45214874461312e-08 NA NA NA hsa-miR-369-3p ELK4 0.0880848299432269 0.48519534195924 -0.295067420379196 0.00481351425113707 mirMAP -0.10307681057764 0.000318559291899688 NA NA NA hsa-miR-3913-5p ELK4 0.71890413546147 2.61153227160465e-13 -0.295067420379196 0.00481351425113707 mirMAP -0.213416591857415 2.86377149653729e-09 NA NA NA hsa-miR-660-5p ELK4 0.406910761707485 0.000156175371762464 -0.295067420379196 0.00481351425113707 mirMAP -0.141603087346672 2.07864834260602e-05 NA NA NA hsa-let-7a-5p FAS -0.210286642041636 0.0072546234707717 -0.759637724162876 2.18688041634812e-12 TargetScan -0.147010045095826 0.00234531576557678 NA NA NA hsa-miR-338-3p FAS 0.0799903526884966 0.575137668326679 -0.759637724162876 2.18688041634812e-12 miRanda -0.16768795837118 1.3473835302647e-10 NA NA NA hsa-miR-98-5p FAS 0.656336869298973 9.03113188590466e-15 -0.759637724162876 2.18688041634812e-12 miRNAWalker2_validate -0.147800482737569 0.000760862411963529 NA NA NA hsa-let-7a-5p FASLG -0.210286642041636 0.0072546234707717 0.202786291597416 0.303256769370056 TargetScan;miRNATAP -0.254557236142898 0.0033640838487851 NA NA NA hsa-let-7b-5p FASLG -0.54215483448257 7.21347617597858e-08 0.202786291597416 0.303256769370056 miRNATAP -0.244673453612857 0.000244706869361269 NA NA NA hsa-let-7e-5p FASLG 0.261471269338985 0.00191077095550257 0.202786291597416 0.303256769370056 miRNATAP -0.337100053640702 2.69864596660333e-05 NA NA NA hsa-miR-16-1-3p FGF1 1.30142784811196 2.53343713753744e-29 -2.3363200609921 2.42261900591497e-58 mirMAP -0.581904531746624 8.04220781640102e-38 NA NA NA hsa-miR-186-5p FGF1 -0.426987301460247 1.04129380549315e-05 -2.3363200609921 2.42261900591497e-58 mirMAP -0.143723594837616 0.00933754138773196 NA NA NA hsa-miR-18a-5p FGF1 0.969066793715868 1.69069796425892e-08 -2.3363200609921 2.42261900591497e-58 MirTarget -0.308725947141596 9.70167258927243e-25 NA NA NA hsa-miR-193a-3p FGF1 0.310617999804917 0.00477640270974957 -2.3363200609921 2.42261900591497e-58 PITA -0.19690022881916 5.07868444768763e-05 NA NA NA hsa-miR-21-5p FGF1 2.32007501846389 3.08394781855554e-137 -2.3363200609921 2.42261900591497e-58 MirTarget -0.371477796734357 9.2806521720649e-15 NA NA NA hsa-miR-29a-5p FGF1 0.334183773952055 0.00445137265870197 -2.3363200609921 2.42261900591497e-58 mirMAP -0.152220555461099 0.000862510868875038 NA NA NA hsa-miR-320b FGF1 0.412787504747938 0.00113457276903985 -2.3363200609921 2.42261900591497e-58 miRanda -0.230047658868655 4.79239651855213e-08 NA NA NA hsa-miR-330-5p FGF1 0.626063225953928 3.42215028606779e-09 -2.3363200609921 2.42261900591497e-58 miRanda;miRNATAP -0.320213335163115 1.22351851936422e-10 NA NA NA hsa-miR-361-5p FGF1 -0.0996867547900457 0.095428250126326 -2.3363200609921 2.42261900591497e-58 miRanda -0.324186160458905 0.000365896398010837 NA NA NA hsa-miR-3913-5p FGF1 0.71890413546147 2.61153227160465e-13 -2.3363200609921 2.42261900591497e-58 mirMAP -0.147478952504203 0.00632555140399931 NA NA NA hsa-miR-429 FGF1 2.84108892259147 3.88520896426515e-64 -2.3363200609921 2.42261900591497e-58 miRNATAP -0.325212393355327 4.60753740095485e-30 NA NA NA hsa-miR-484 FGF1 0.349444060004737 0.00154491249625173 -2.3363200609921 2.42261900591497e-58 MirTarget;PITA;miRNATAP -0.350837387269644 2.42230585979755e-13 NA NA NA hsa-miR-532-3p FGF1 -0.395473145042459 0.00686714288452761 -2.3363200609921 2.42261900591497e-58 miRNATAP -0.135400728049064 0.000208318514603032 NA NA NA hsa-miR-550a-5p FGF1 -0.12364998419382 0.410467966112492 -2.3363200609921 2.42261900591497e-58 MirTarget -0.124015992653408 0.000650072833531158 NA NA NA hsa-miR-576-5p FGF1 0.0649387707567879 0.588791966096287 -2.3363200609921 2.42261900591497e-58 PITA;mirMAP -0.195551405525261 1.13745464101402e-05 NA NA NA hsa-miR-590-5p FGF1 0.746515607868274 8.51300479640125e-09 -2.3363200609921 2.42261900591497e-58 MirTarget;miRanda;miRNATAP -0.370669749508457 2.36068553671594e-20 NA NA NA hsa-miR-625-5p FGF1 0.728939236913178 5.97591217674307e-08 -2.3363200609921 2.42261900591497e-58 MirTarget -0.241254403404484 2.5870605302491e-09 NA NA NA hsa-miR-629-5p FGF1 0.42411327890895 2.46262300605706e-05 -2.3363200609921 2.42261900591497e-58 MirTarget -0.28293563961806 8.96106894697866e-08 NA NA NA hsa-miR-200b-3p FGF10 2.11744072703209 1.66710572104191e-43 -3.32771291998068 2.19492306477012e-23 TargetScan -0.477562798964516 3.55044319062017e-11 NA NA NA hsa-let-7a-5p FGF11 -0.210286642041636 0.0072546234707717 -0.654203699022933 6.56875051109305e-06 TargetScan;mirMAP;miRNATAP -0.267012754520769 3.15077825833402e-05 NA NA NA hsa-let-7b-5p FGF11 -0.54215483448257 7.21347617597858e-08 -0.654203699022933 6.56875051109305e-06 mirMAP;miRNATAP -0.138105904475298 0.00527683385622591 NA NA NA hsa-miR-331-3p FGF11 0.74441480542886 1.17071235477799e-07 -0.654203699022933 6.56875051109305e-06 miRNATAP -0.11808385160736 0.000829591224831171 NA NA NA hsa-miR-142-5p FGF12 1.16509303143593 1.96641162209073e-13 -0.643446523257955 0.000892623765099953 miRNATAP -0.125050416843925 0.00249966609947065 NA NA NA hsa-miR-17-5p FGF12 0.599531757298529 1.07318660415906e-05 -0.643446523257955 0.000892623765099953 TargetScan -0.150807716699532 0.00194136781001414 NA NA NA hsa-miR-200b-3p FGF12 2.11744072703209 1.66710572104191e-43 -0.643446523257955 0.000892623765099953 TargetScan -0.165329959072644 5.71604844896826e-05 NA NA NA hsa-miR-429 FGF12 2.84108892259147 3.88520896426515e-64 -0.643446523257955 0.000892623765099953 miRNATAP -0.122602237479307 0.000847169715536382 NA NA NA hsa-miR-455-5p FGF12 0.284641224662773 0.0357572339594277 -0.643446523257955 0.000892623765099953 miRanda -0.362285996207897 7.81172946390217e-14 NA NA NA hsa-miR-542-3p FGF12 0.568822103820889 8.5699075257651e-07 -0.643446523257955 0.000892623765099953 miRanda -0.186594268922009 0.00113571395430377 NA NA NA hsa-miR-141-3p FGF13 2.99777540204168 1.26370498493024e-78 -0.873614793965912 3.10323995957847e-07 TargetScan -0.151235108253828 5.55097538879746e-06 NA NA NA hsa-miR-142-5p FGF13 1.16509303143593 1.96641162209073e-13 -0.873614793965912 3.10323995957847e-07 PITA -0.171463579066746 2.60043790328601e-06 NA NA NA hsa-miR-200a-5p FGF13 2.58844508672328 1.79650654234569e-56 -0.873614793965912 3.10323995957847e-07 MirTarget;miRNATAP -0.144569347995968 1.56153098119586e-05 NA NA NA hsa-miR-590-3p FGF13 1.27438512890514 1.03164723481469e-23 -0.873614793965912 3.10323995957847e-07 miRanda -0.139748708534672 0.00308905149188458 NA NA NA hsa-miR-590-3p FGF14 1.27438512890514 1.03164723481469e-23 -0.743601748556524 2.04913944157729e-05 miRanda -0.437013841225084 1.73317372660872e-20 NA NA NA hsa-miR-96-5p FGF14 3.24596558166606 1.92296159041707e-98 -0.743601748556524 2.04913944157729e-05 TargetScan -0.186868577790991 5.83679167463715e-08 NA NA NA hsa-miR-15b-5p FGF18 0.788659356634696 1.13678211092534e-11 0.356025539172725 0.0347430848266563 miRNATAP -0.278632009163133 1.22698938766975e-08 NA NA NA hsa-miR-16-5p FGF18 0.46835991343556 1.91125356547776e-06 0.356025539172725 0.0347430848266563 miRNATAP -0.407440682812312 2.18411630304885e-12 NA NA NA hsa-miR-200b-3p FGF18 2.11744072703209 1.66710572104191e-43 0.356025539172725 0.0347430848266563 TargetScan -0.225608292610904 1.9483944408265e-10 NA NA NA hsa-miR-200c-3p FGF18 2.07038651806183 6.84613386286599e-51 0.356025539172725 0.0347430848266563 miRNATAP -0.297918294437242 1.5236208240269e-14 NA NA NA hsa-miR-326 FGF18 -1.54449030848141 1.04703417845594e-17 0.356025539172725 0.0347430848266563 PITA;miRanda;miRNATAP -0.120554064884584 0.000122916185329087 NA NA NA hsa-miR-330-5p FGF18 0.626063225953928 3.42215028606779e-09 0.356025539172725 0.0347430848266563 PITA;miRanda;miRNATAP -0.264450945601235 9.7958776270154e-07 NA NA NA hsa-miR-362-5p FGF18 -0.248676340901797 0.0726089851456282 0.356025539172725 0.0347430848266563 miRNATAP -0.160150519329221 0.000123017502928388 NA NA NA hsa-miR-424-5p FGF18 0.420789584199235 0.00480101660479489 0.356025539172725 0.0347430848266563 miRNATAP -0.118258719392065 0.00224759503637084 NA NA NA hsa-miR-429 FGF18 2.84108892259147 3.88520896426515e-64 0.356025539172725 0.0347430848266563 miRNATAP -0.192282799804847 1.28904804259296e-09 NA NA NA hsa-miR-505-3p FGF18 -0.530462599544864 7.71645736541597e-05 0.356025539172725 0.0347430848266563 miRNATAP -0.37019252141977 1.51921477550048e-18 NA NA NA hsa-miR-590-5p FGF18 0.746515607868274 8.51300479640125e-09 0.356025539172725 0.0347430848266563 miRanda;miRNATAP -0.439643988772613 1.86198557821583e-24 NA NA NA hsa-miR-9-5p FGF18 0.734772328078424 0.00261982843636383 0.356025539172725 0.0347430848266563 miRNATAP -0.200718216328244 4.25037312625656e-18 NA NA NA hsa-let-7a-3p FGF2 0.466622567891891 3.70886257943079e-07 -3.62110997961421 1.11252046868458e-69 mirMAP -0.291818855316242 0.000475924803881402 NA NA NA hsa-let-7f-1-3p FGF2 0.37532726250321 0.00156021688753682 -3.62110997961421 1.11252046868458e-69 mirMAP -0.20077854516594 0.00221318919252559 NA NA NA hsa-miR-103a-3p FGF2 0.610673390034345 1.63113920514646e-12 -3.62110997961421 1.11252046868458e-69 miRNAWalker2_validate;MirTarget;miRNATAP -0.723924551136195 6.60361690701997e-17 NA NA NA hsa-miR-107 FGF2 0.678998026350662 2.56224148930538e-16 -3.62110997961421 1.11252046868458e-69 MirTarget;PITA;miRanda;miRNATAP -0.796465331145451 7.23286562379616e-19 NA NA NA hsa-miR-142-3p FGF2 1.53951237846104 2.06769936282034e-17 -3.62110997961421 1.11252046868458e-69 miRanda -0.17283302588329 2.98031372863511e-05 NA NA NA hsa-miR-155-5p FGF2 1.09766314984151 4.55650930885814e-15 -3.62110997961421 1.11252046868458e-69 miRNAWalker2_validate;mirMAP -0.14901722637598 0.00579079439331683 NA NA NA hsa-miR-15a-5p FGF2 0.812445324157528 4.50263417099822e-20 -3.62110997961421 1.11252046868458e-69 MirTarget;miRNATAP -0.693907136905669 1.18654679034038e-16 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-3p FGF2 1.12898579025388 1.18050912917317e-14 -3.62110997961421 1.11252046868458e-69 mirMAP -0.416639852881488 2.41684465169063e-16 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-5p FGF2 0.788659356634696 1.13678211092534e-11 -3.62110997961421 1.11252046868458e-69 MirTarget;miRNATAP -0.416542064799323 1.32439928134663e-10 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-1-3p FGF2 1.30142784811196 2.53343713753744e-29 -3.62110997961421 1.11252046868458e-69 mirMAP -0.618895974599859 1.26519964172122e-20 NA NA NA hsa-miR-16-2-3p FGF2 0.286355254959005 0.0256946046884474 -3.62110997961421 1.11252046868458e-69 mirMAP -0.190718116559883 0.00155781442617599 NA NA NA hsa-miR-16-5p FGF2 0.46835991343556 1.91125356547776e-06 -3.62110997961421 1.11252046868458e-69 miRNAWalker2_validate;MirTarget;miRNATAP -0.334764026766057 1.68868207410758e-05 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-181a-5p FGF2 0.635863607630183 6.72486918157744e-11 -3.62110997961421 1.11252046868458e-69 mirMAP -0.445820481795785 9.84329484201549e-09 NA NA NA hsa-miR-181b-5p FGF2 1.22749257795094 1.21998198830919e-27 -3.62110997961421 1.11252046868458e-69 mirMAP -0.542719617785167 6.40042754935602e-17 NA NA NA hsa-miR-181c-5p FGF2 0.574847839298605 4.51287502066478e-07 -3.62110997961421 1.11252046868458e-69 mirMAP -0.226227363468224 0.00075162633624824 NA NA NA hsa-miR-192-5p FGF2 1.33366224451777 9.5116159697107e-29 -3.62110997961421 1.11252046868458e-69 miRNAWalker2_validate -0.492571390734632 6.64406170620692e-16 NA NA NA hsa-miR-19b-1-5p FGF2 0.647704962003062 3.07687667945597e-07 -3.62110997961421 1.11252046868458e-69 mirMAP -0.220669191860133 0.000256708213140997 NA NA NA hsa-miR-200b-3p FGF2 2.11744072703209 1.66710572104191e-43 -3.62110997961421 1.11252046868458e-69 mirMAP -0.474105291344653 1.09246839719196e-24 NA NA NA hsa-miR-200c-3p FGF2 2.07038651806183 6.84613386286599e-51 -3.62110997961421 1.11252046868458e-69 mirMAP -0.615252170517975 1.40903756446366e-34 NA NA NA hsa-miR-21-3p FGF2 2.17476065946878 5.15299442583591e-75 -3.62110997961421 1.11252046868458e-69 mirMAP -0.712905950790447 1.55737305852276e-36 NA NA NA hsa-miR-21-5p FGF2 2.32007501846389 3.08394781855554e-137 -3.62110997961421 1.11252046868458e-69 mirMAP -1.0007316696677 9.45001605861665e-53 NA NA NA hsa-miR-32-5p FGF2 1.38676603945192 2.29428299685976e-34 -3.62110997961421 1.11252046868458e-69 miRNAWalker2_validate -0.601478209606274 2.96886796474821e-21 NA NA NA hsa-miR-330-3p FGF2 0.432728362037032 0.00041335506960812 -3.62110997961421 1.11252046868458e-69 mirMAP -0.190108192654775 0.00276026518304351 NA NA NA hsa-miR-429 FGF2 2.84108892259147 3.88520896426515e-64 -3.62110997961421 1.11252046868458e-69 mirMAP -0.50658475327409 1.36690059845309e-35 NA NA NA hsa-miR-503-5p FGF2 1.89861508626371 8.64468509978193e-28 -3.62110997961421 1.11252046868458e-69 miRNAWalker2_validate -0.318786957596351 2.28520886786229e-13 NA NA NA hsa-miR-590-3p FGF2 1.27438512890514 1.03164723481469e-23 -3.62110997961421 1.11252046868458e-69 miRanda;mirMAP -0.434908422832851 8.74942691621125e-13 NA NA NA hsa-miR-590-5p FGF2 0.746515607868274 8.51300479640125e-09 -3.62110997961421 1.11252046868458e-69 miRanda;mirMAP -0.340101326786598 5.86637073853323e-09 NA NA NA hsa-miR-93-3p FGF2 0.627759242044891 3.62527588304617e-06 -3.62110997961421 1.11252046868458e-69 mirMAP -0.374363069604572 2.04134280501924e-11 NA NA NA hsa-let-7a-3p FGF7 0.466622567891891 3.70886257943079e-07 -2.04584639946267 6.89325129361849e-43 MirTarget;miRNATAP -0.291554234913666 5.86497309861538e-07 NA NA NA hsa-miR-107 FGF7 0.678998026350662 2.56224148930538e-16 -2.04584639946267 6.89325129361849e-43 PITA;miRanda;miRNATAP -0.546294975137966 4.4731046654949e-18 NA NA NA hsa-miR-15a-5p FGF7 0.812445324157528 4.50263417099822e-20 -2.04584639946267 6.89325129361849e-43 miRTarBase;miRNATAP -0.531335245933583 1.07978052597967e-19 NA NA NA hsa-miR-15b-5p FGF7 0.788659356634696 1.13678211092534e-11 -2.04584639946267 6.89325129361849e-43 miRNATAP -0.294334950139095 9.5895878173005e-11 NA NA NA hsa-miR-16-1-3p FGF7 1.30142784811196 2.53343713753744e-29 -2.04584639946267 6.89325129361849e-43 mirMAP -0.437128601027858 6.61913037421969e-21 NA NA NA hsa-miR-16-2-3p FGF7 0.286355254959005 0.0256946046884474 -2.04584639946267 6.89325129361849e-43 mirMAP -0.225774074048836 7.90334438903079e-08 NA NA NA hsa-miR-16-5p FGF7 0.46835991343556 1.91125356547776e-06 -2.04584639946267 6.89325129361849e-43 miRNATAP -0.294993672554423 5.86741065196244e-08 NA NA NA hsa-miR-20a-5p FGF7 0.44979911120222 0.000602386964327228 -2.04584639946267 6.89325129361849e-43 miRNAWalker2_validate -0.243033729024757 2.41787962262626e-09 NA NA NA hsa-miR-30d-3p FGF7 0.264544633563642 0.00755023189129747 -2.04584639946267 6.89325129361849e-43 miRNATAP -0.316263621956414 5.48336610985585e-09 NA NA NA hsa-miR-320b FGF7 0.412787504747938 0.00113457276903985 -2.04584639946267 6.89325129361849e-43 miRanda -0.139459566850431 0.00108196556023217 NA NA NA hsa-miR-340-5p FGF7 1.0857159627596 4.94471062546756e-24 -2.04584639946267 6.89325129361849e-43 mirMAP -0.279133011350609 9.24446622871117e-09 NA NA NA hsa-miR-429 FGF7 2.84108892259147 3.88520896426515e-64 -2.04584639946267 6.89325129361849e-43 miRNATAP -0.366295181453287 6.14104708947163e-38 NA NA NA hsa-miR-484 FGF7 0.349444060004737 0.00154491249625173 -2.04584639946267 6.89325129361849e-43 PITA -0.168542958718501 0.000557416327492428 NA NA NA hsa-miR-590-3p FGF7 1.27438512890514 1.03164723481469e-23 -2.04584639946267 6.89325129361849e-43 PITA;miRanda;mirMAP;miRNATAP -0.299954971963049 2.12582339280064e-12 NA NA NA hsa-miR-590-5p FGF7 0.746515607868274 8.51300479640125e-09 -2.04584639946267 6.89325129361849e-43 PITA;miRanda -0.248349796532555 1.32069527646423e-09 NA NA NA hsa-miR-7-1-3p FGF7 0.686579567507582 1.20731554448806e-07 -2.04584639946267 6.89325129361849e-43 mirMAP -0.291915571429539 8.2244137316862e-13 NA NA NA hsa-miR-15a-5p FGF9 0.812445324157528 4.50263417099822e-20 -2.4852262043005 1.90052930236681e-24 miRNATAP -0.453532492537739 1.81189938850602e-06 NA NA NA hsa-miR-16-5p FGF9 0.46835991343556 1.91125356547776e-06 -2.4852262043005 1.90052930236681e-24 miRNATAP -0.265584515990919 0.00235373908707608 NA NA NA hsa-miR-181b-5p FGF9 1.22749257795094 1.21998198830919e-27 -2.4852262043005 1.90052930236681e-24 mirMAP -0.251706769659496 0.000662639171300449 NA NA NA hsa-miR-182-5p FGF9 2.36408084103818 2.60011457600281e-72 -2.4852262043005 1.90052930236681e-24 miRTarBase;miRNATAP -0.452581728187924 1.53870203091154e-14 NA NA NA hsa-miR-183-5p FGF9 2.95681814393872 1.09965777344285e-92 -2.4852262043005 1.90052930236681e-24 miRNATAP -0.421051105687966 5.55191507820402e-16 NA NA NA hsa-miR-429 FGF9 2.84108892259147 3.88520896426515e-64 -2.4852262043005 1.90052930236681e-24 miRanda -0.319482141660943 1.05794965240276e-11 NA NA NA hsa-miR-590-3p FGF9 1.27438512890514 1.03164723481469e-23 -2.4852262043005 1.90052930236681e-24 miRanda;mirMAP -0.208237924178229 0.00252074976910256 NA NA NA hsa-miR-96-5p FGF9 3.24596558166606 1.92296159041707e-98 -2.4852262043005 1.90052930236681e-24 TargetScan;miRNATAP -0.44484666162403 4.74837998245841e-20 NA NA NA hsa-miR-106a-5p FGFR1 0.574594373206545 0.000145868284001732 -1.14663914385064 6.08915041092458e-18 mirMAP -0.140764850201839 4.05395479162201e-06 NA NA NA hsa-miR-106b-5p FGFR1 1.22477789913175 2.31787213143326e-32 -1.14663914385064 6.08915041092458e-18 mirMAP -0.187712904592992 1.40602847883516e-05 NA NA NA hsa-miR-15a-5p FGFR1 0.812445324157528 4.50263417099822e-20 -1.14663914385064 6.08915041092458e-18 miRNATAP -0.158299254797074 0.00214218396058389 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-5p FGFR1 0.788659356634696 1.13678211092534e-11 -1.14663914385064 6.08915041092458e-18 miRNATAP -0.1205608912803 0.00233144736273568 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-5p FGFR1 0.46835991343556 1.91125356547776e-06 -1.14663914385064 6.08915041092458e-18 miRTarBase;miRNATAP -0.183714075820348 9.67034011184e-05 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-200a-5p FGFR1 2.58844508672328 1.79650654234569e-56 -1.14663914385064 6.08915041092458e-18 mirMAP -0.215721842068481 1.13267932151434e-16 NA NA NA hsa-miR-200b-5p FGFR1 1.43091697052145 2.07975242866479e-22 -1.14663914385064 6.08915041092458e-18 mirMAP -0.16607698201377 1.28945935874685e-07 NA NA NA hsa-miR-20b-5p FGFR1 0.78236583455125 8.7938334801223e-05 -1.14663914385064 6.08915041092458e-18 mirMAP -0.115810849796481 5.3473776263928e-07 NA NA NA hsa-miR-301a-3p FGFR1 1.32170168375632 2.12280368957514e-15 -1.14663914385064 6.08915041092458e-18 mirMAP -0.10939487939016 7.18051162231598e-05 NA NA NA hsa-miR-330-3p FGFR1 0.432728362037032 0.00041335506960812 -1.14663914385064 6.08915041092458e-18 PITA;miRNATAP -0.10383346919971 0.00691823598065563 NA NA NA hsa-miR-330-5p FGFR1 0.626063225953928 3.42215028606779e-09 -1.14663914385064 6.08915041092458e-18 miRanda;miRNATAP -0.200093067000453 4.15731266944936e-06 NA NA NA hsa-miR-455-5p FGFR1 0.284641224662773 0.0357572339594277 -1.14663914385064 6.08915041092458e-18 miRanda -0.107782773565761 0.0016907871459656 NA NA NA hsa-miR-590-3p FGFR1 1.27438512890514 1.03164723481469e-23 -1.14663914385064 6.08915041092458e-18 miRanda;mirMAP -0.232790337775512 2.91176217126465e-10 NA NA NA hsa-miR-93-5p FGFR1 1.01788600209314 1.24312921618126e-21 -1.14663914385064 6.08915041092458e-18 mirMAP -0.155396198762809 0.000265353923933065 NA NA NA hsa-miR-107 FGFR2 0.678998026350662 2.56224148930538e-16 -0.775141603791194 2.04453402884716e-05 PITA;miRanda -0.355887284370132 1.72803357435902e-06 NA NA NA hsa-miR-193a-3p FGFR2 0.310617999804917 0.00477640270974957 -0.775141603791194 2.04453402884716e-05 miRanda -0.294573603452518 2.04016256999751e-07 NA NA NA hsa-miR-369-3p FGFR2 0.0880848299432269 0.48519534195924 -0.775141603791194 2.04453402884716e-05 miRNATAP -0.134882932202002 0.00703831397411665 NA NA NA hsa-miR-423-3p FGFR2 0.338351552541003 0.000947983901628776 -0.775141603791194 2.04453402884716e-05 PITA;miRNATAP -0.1727701841783 0.00483828495442655 NA NA NA hsa-miR-590-3p FGFR2 1.27438512890514 1.03164723481469e-23 -0.775141603791194 2.04453402884716e-05 miRanda -0.203907123628065 4.71460047941147e-05 NA NA NA hsa-miR-100-5p FGFR3 -1.89453309391092 5.00588682382388e-51 1.86754699235588 2.21866053477893e-14 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.235261430958759 0.000205428105475304 25344675;26604796;26018508;23778527 MicroRNA 100 regulates pancreatic cancer cells growth and sensitivity to chemotherapy through targeting FGFR3; The predicted target of miR-100 fibroblast growth factor receptor 3 FGFR3 was downregulated by siRNA to examine its effect on pancreatic cancer cells; Luciferase essay showed FGFR3 was direct target of miR-100; FGFR3 was significantly downregulated by overexpressing miR-100 in pancreatic cancer cells and knocking down FGFR3 by siRNA exerted similar effect as miR-100; Our study demonstrated that miR-100 played an important role in pancreatic cancer development possibly through targeting FGFR3;Overexpression of miR 100 inhibits cell proliferation migration and chemosensitivity in human glioblastoma through FGFR3; Expression of fibroblast growth factor receptor 3 FGFR3 the bioinformatically predicted target of miR-100 was examined by Western blot in glioblastoma; FGFR3 was directly regulated by miR-100 in glioblastoma; Ectopically overexpressing FGFR3 was able to ameliorate the anticancer effects of upregulation of miR-100 on glioblastoma growth migration and chemosensitivity; Overexpressing miR-100 had anticancer effects on glioblastoma likely through regulation of FGFR3;Overexpression of miR 100 inhibits growth of osteosarcoma through FGFR3; Here we reported significantly higher levels of fibroblast growth factor receptor 3 FGFR3 and significantly lower levels of miR-100 in the OS specimen compared to those in the paired normal bone tissues; Bioinformatics analysis and luciferase reporter assay suggest that miR-100 binds to the 3'UTR of FGFR3 mRNA to prevent its translation; Taken together our data demonstrate that miR-100 may inhibit the growth of OS through FGFR3;Hypoxia regulates FGFR3 expression via HIF 1α and miR 100 and contributes to cell survival in non muscle invasive bladder cancer; We have previously investigated the role of microRNAs in bladder cancer and have shown that FGFR3 is a target of miR-100; In this study we investigated the effects of hypoxia on miR-100 and FGFR3 expression and the link between miR-100 and FGFR3 in hypoxia; Bladder cancer cell lines were exposed to normoxic or hypoxic conditions and examined for the expression of FGFR3 by quantitative PCR qPCR and western blotting and miR-100 by qPCR; The effect of FGFR3 and miR-100 on cell viability in two-dimensional 2-D and three-dimensional 3-D was examined by transfecting siRNA or mimic-100 respectively; Increased FGFR3 was also in part dependent on miR-100 levels which decreased in hypoxia; Hypoxia in part via suppression of miR-100 induces FGFR3 expression in bladder cancer both of which have an important role in maintaining cell viability under conditions of stress ;;;poor survival pancreatic cancer;glioblastoma;sarcoma;bladder cancer hsa-miR-142-3p FGFR3 1.53951237846104 2.06769936282034e-17 1.86754699235588 2.21866053477893e-14 miRanda -0.186690154425788 4.78356753122835e-05 NA NA NA hsa-miR-19a-3p FGFR3 0.817507952171848 3.76285090469625e-08 1.86754699235588 2.21866053477893e-14 mirMAP -0.197762599825557 0.000503996109696735 NA NA NA hsa-miR-19b-3p FGFR3 0.139124391010031 0.255658553872934 1.86754699235588 2.21866053477893e-14 mirMAP -0.298900555145995 1.74346769891144e-05 NA NA NA hsa-miR-24-3p FGFR3 -0.120123317289941 0.21432376743243 1.86754699235588 2.21866053477893e-14 MirTarget;miRNATAP -0.593260915828542 1.24772160110599e-11 NA NA NA hsa-miR-337-3p FGFR3 -2.14274617598363 2.70942896809734e-43 1.86754699235588 2.21866053477893e-14 MirTarget -0.276342803887382 8.88392937600617e-08 NA NA NA hsa-miR-455-3p FGFR3 0.678392920628872 0.000327758844555877 1.86754699235588 2.21866053477893e-14 PITA -0.311970748789501 2.16597532806041e-12 NA NA NA hsa-miR-532-5p FGFR3 0.0386976222860582 0.682018574136515 1.86754699235588 2.21866053477893e-14 mirMAP -0.285596505551977 0.00164247472635195 NA NA NA hsa-miR-99a-5p FGFR3 -2.25079447371102 1.14086813185885e-54 1.86754699235588 2.21866053477893e-14 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.320837636799125 4.30235413296182e-09 23409016;24456664;23298836 Photofrin based photodynamic therapy and miR 99a transfection inhibited FGFR3 and PI3K/Akt signaling mechanisms to control growth of human glioblastoma In vitro and in vivo; Further photofrin based PDT followed by miR-99a transfection dramatically increased miR-99a expression and also increased apoptosis in glioblastoma cell cultures and drastically reduced tumor growth in athymic nude mice due to down regulation of fibroblast growth factor receptor 3 FGFR3 and PI3K/Akt signaling mechanisms leading to inhibition of cell proliferation and induction of molecular mechanisms of apoptosis;miR 99a promotes proliferation targeting FGFR3 in human epithelial ovarian cancer cells; Importantly fibroblast growth factor receptor 3 FGFR3 predicted to be one target gene of miR-99a using computational algorithms was higher in expression in EOC cells; Subsequently FGFR3 was proved to be direct target of miR-99a by dual luciferase assay; Furthermore overexpression of miR-99a dramatically suppressed expression level of FGFR3 at both mRNA and protein levels proving FGFR3 to be inversely correlated with miR-99a; Finally overexpression of miR-99a could significantly inhibit EOC cell proliferation in vitro by decreasing the expression of FGFR3 which also reduced the EOC cell growth after siRNA knockdown; Conclusively miR-99a expression was remarkably downregulated in serums tissues and cell and suppresses EOC cell proliferation by targeting FGFR3 suggesting miR-99a as a prospective prognosis marker and potential tumor suppressor for EOC therapeutics;The tumorigenic FGFR3 TACC3 gene fusion escapes miR 99a regulation in glioblastoma; The fusion caused by tandem duplication on 4p16.3 led to the loss of the 3'-UTR of FGFR3 blocking gene regulation of miR-99a and enhancing expression of the fusion gene ;worse prognosis; glioblastoma;ovarian cancer;glioblastoma hsa-miR-326 FGFR4 -1.54449030848141 1.04703417845594e-17 1.53418109992094 1.4752304353364e-09 miRanda;miRNATAP -0.170195226279497 0.000361551375916332 NA NA NA hsa-miR-491-5p FGFR4 -1.04307210952796 1.14586501470398e-15 1.53418109992094 1.4752304353364e-09 miRanda -0.298147283214882 7.57138894516634e-06 NA NA NA hsa-miR-149-5p FLNA 0.218233101703391 0.261629158371175 -0.588648086634478 1.12488656429227e-08 miRNAWalker2_validate -0.104936764513895 7.86778756479402e-09 NA NA NA hsa-miR-16-5p FLNA 0.46835991343556 1.91125356547776e-06 -0.588648086634478 1.12488656429227e-08 miRNAWalker2_validate -0.172916693939482 1.57998325738482e-06 NA NA NA hsa-miR-200c-3p FLNA 2.07038651806183 6.84613386286599e-51 -0.588648086634478 1.12488656429227e-08 miRNAWalker2_validate -0.200293197507804 3.85868552345297e-17 NA NA NA hsa-let-7c-5p FLNB -1.9415540533505 9.55250745007793e-48 0.411917423584987 1.38597258696823e-05 miRNAWalker2_validate -0.115803027940097 4.14187891331327e-07 NA NA NA hsa-miR-155-5p FLNB 1.09766314984151 4.55650930885814e-15 0.411917423584987 1.38597258696823e-05 miRNAWalker2_validate -0.162105330554931 7.83062477234271e-13 NA NA NA hsa-miR-22-5p FLNB 0.238328801322329 0.0377496760295305 0.411917423584987 1.38597258696823e-05 mirMAP -0.198687801749331 1.68458410389996e-12 NA NA NA hsa-miR-532-5p FLNB 0.0386976222860582 0.682018574136515 0.411917423584987 1.38597258696823e-05 mirMAP -0.221702137120282 1.15856855812428e-10 NA NA NA hsa-miR-582-3p FLNB 0.126152488945932 0.333088461939587 0.411917423584987 1.38597258696823e-05 mirMAP -0.140291693114414 1.76547105822434e-08 NA NA NA hsa-miR-582-5p FLNB 0.201134299470983 0.149482495292227 0.411917423584987 1.38597258696823e-05 miRNATAP -0.143884652032171 8.58854341418221e-10 NA NA NA hsa-miR-142-3p FLNC 1.53951237846104 2.06769936282034e-17 -2.00753417382474 1.80597405022656e-29 miRanda -0.240476394290762 1.06946167914816e-12 NA NA NA hsa-miR-19a-3p FLNC 0.817507952171848 3.76285090469625e-08 -2.00753417382474 1.80597405022656e-29 miRNATAP -0.354356793574727 1.32344686907557e-17 NA NA NA hsa-miR-19b-3p FLNC 0.139124391010031 0.255658553872934 -2.00753417382474 1.80597405022656e-29 miRNATAP -0.371662579324767 3.80037186329658e-13 NA NA NA hsa-miR-320b FLNC 0.412787504747938 0.00113457276903985 -2.00753417382474 1.80597405022656e-29 PITA;miRanda;miRNATAP -0.294929260196682 3.06936909649809e-09 NA NA NA hsa-miR-330-5p FLNC 0.626063225953928 3.42215028606779e-09 -2.00753417382474 1.80597405022656e-29 miRanda -0.468147821965326 1.13652766780054e-15 NA NA NA hsa-miR-342-3p FLNC 1.21944481975657 6.81914373001202e-19 -2.00753417382474 1.80597405022656e-29 miRanda;miRNATAP -0.448119463414152 1.69722682527763e-24 NA NA NA hsa-miR-454-3p FLNC 1.28177672191095 6.84024979484587e-21 -2.00753417382474 1.80597405022656e-29 miRNAWalker2_validate -0.485402592144174 2.88640634695113e-28 NA NA NA hsa-miR-142-5p FOS 1.16509303143593 1.96641162209073e-13 -2.7451718741702 2.64568082199498e-43 PITA -0.12207759286834 0.00640616480771789 NA NA NA hsa-miR-155-5p FOS 1.09766314984151 4.55650930885814e-15 -2.7451718741702 2.64568082199498e-43 MirTarget -0.240444909500681 1.82003092155439e-06 23693020 Also S100P treatment stimulated the enrichment of c-Fos an AP-1 family member at the miR-155 host gene promoter site colon cancer hsa-miR-181a-5p FOS 0.635863607630183 6.72486918157744e-11 -2.7451718741702 2.64568082199498e-43 miRNAWalker2_validate;miRTarBase;miRNATAP -0.410948031055006 1.7230387501528e-08 NA NA NA hsa-miR-181b-5p FOS 1.22749257795094 1.21998198830919e-27 -2.7451718741702 2.64568082199498e-43 miRNATAP -0.461169479158613 4.35706262719131e-14 NA NA NA hsa-miR-181c-5p FOS 0.574847839298605 4.51287502066478e-07 -2.7451718741702 2.64568082199498e-43 miRNATAP -0.297666073945719 2.06076630907263e-06 NA NA NA hsa-miR-192-5p FOS 1.33366224451777 9.5116159697107e-29 -2.7451718741702 2.64568082199498e-43 miRNAWalker2_validate -0.573943949936604 3.18133466007259e-24 NA NA NA hsa-miR-29b-3p FOS 0.438847962603729 6.46722433236121e-05 -2.7451718741702 2.64568082199498e-43 miRNAWalker2_validate;MirTarget;miRNATAP -0.323186683829661 7.1570553399104e-07 NA NA NA hsa-miR-3065-3p FOS 1.62787885002468 6.81477830005026e-19 -2.7451718741702 2.64568082199498e-43 MirTarget;miRNATAP -0.192321809403356 4.786045679399e-07 NA NA NA hsa-miR-501-3p FOS 0.0448022813406874 0.711710441403614 -2.7451718741702 2.64568082199498e-43 MirTarget;PITA;miRNATAP -0.268860579047235 6.00625856694287e-06 NA NA NA hsa-miR-502-3p FOS 0.11461741546458 0.276553832470138 -2.7451718741702 2.64568082199498e-43 MirTarget;PITA;miRNATAP -0.211273151818318 0.00209393237707859 NA NA NA hsa-miR-576-5p FOS 0.0649387707567879 0.588791966096287 -2.7451718741702 2.64568082199498e-43 PITA -0.293798710471614 9.14658380731072e-07 NA NA NA hsa-miR-589-3p FOS 0.0263457630961427 0.866577983997705 -2.7451718741702 2.64568082199498e-43 MirTarget -0.25439843426902 5.26315554700153e-08 NA NA NA hsa-miR-590-3p FOS 1.27438512890514 1.03164723481469e-23 -2.7451718741702 2.64568082199498e-43 miRanda -0.566395526805679 6.60790668638515e-24 NA NA NA hsa-miR-148b-3p GADD45A 1.0552576751879 1.6679285705231e-29 -0.208892067351644 0.0348101740051854 MirTarget -0.231496451348305 2.77073546077852e-11 NA NA NA hsa-miR-331-5p GADD45A 0.682437632502949 4.10871642662371e-11 -0.208892067351644 0.0348101740051854 PITA;miRNATAP -0.123517623290777 0.000150251086827537 NA NA NA hsa-miR-1976 GADD45B 0.289190368864725 0.00167092758216584 0.00189543029343842 0.986264142476403 miRNATAP -0.184077522593828 6.9983734252811e-06 NA NA NA hsa-miR-324-3p GADD45B 0.404877731996915 0.000340036423920834 0.00189543029343842 0.986264142476403 MirTarget;miRNATAP -0.272759607730261 8.22009676059255e-17 NA NA NA hsa-miR-590-3p GADD45B 1.27438512890514 1.03164723481469e-23 0.00189543029343842 0.986264142476403 miRanda -0.144434950089762 1.57603896644092e-06 NA NA NA hsa-miR-1468-5p GADD45G -1.39112473580933 7.93337422009489e-22 1.62405350947909 6.25407490128674e-20 MirTarget -0.329853422258391 1.46530042095361e-15 NA NA NA hsa-miR-1976 GADD45G 0.289190368864725 0.00167092758216584 1.62405350947909 6.25407490128674e-20 MirTarget -0.31549221771233 3.22063864824767e-06 NA NA NA hsa-miR-107 GNG12 0.678998026350662 2.56224148930538e-16 -1.00662202078145 1.13075382846906e-21 miRanda -0.551701699322264 2.91176766840327e-39 NA NA NA hsa-miR-30d-3p GNG12 0.264544633563642 0.00755023189129747 -1.00662202078145 1.13075382846906e-21 mirMAP -0.208468484284917 2.20758275785736e-08 NA NA NA hsa-miR-374a-5p GNG12 -0.239709888246804 0.00309819667153627 -1.00662202078145 1.13075382846906e-21 mirMAP -0.224009250033915 9.67825178709072e-07 NA NA NA hsa-miR-374b-5p GNG12 -0.466781429946153 1.17238311619116e-08 -1.00662202078145 1.13075382846906e-21 mirMAP -0.149043145224379 0.000959250373367468 NA NA NA hsa-miR-423-5p GNG12 -0.0644843381453004 0.462275547464843 -1.00662202078145 1.13075382846906e-21 miRNAWalker2_validate -0.232418945817642 3.66766754252117e-08 NA NA NA hsa-miR-429 GNG12 2.84108892259147 3.88520896426515e-64 -1.00662202078145 1.13075382846906e-21 miRanda -0.170551562257512 1.90032220822832e-17 NA NA NA hsa-miR-455-5p GNG12 0.284641224662773 0.0357572339594277 -1.00662202078145 1.13075382846906e-21 miRanda -0.136447911297092 5.25157686814491e-07 NA NA NA hsa-miR-508-3p GNG12 0.260698649973977 0.189926238144551 -1.00662202078145 1.13075382846906e-21 mirMAP -0.121287386585328 6.28721215718235e-11 NA NA NA hsa-miR-542-3p GNG12 0.568822103820889 8.5699075257651e-07 -1.00662202078145 1.13075382846906e-21 miRanda -0.112752886973826 0.000401656809905115 NA NA NA hsa-miR-590-3p GNG12 1.27438512890514 1.03164723481469e-23 -1.00662202078145 1.13075382846906e-21 miRanda;mirMAP -0.230577467147612 2.85613249871964e-15 NA NA NA hsa-miR-590-5p GNG12 0.746515607868274 8.51300479640125e-09 -1.00662202078145 1.13075382846906e-21 PITA -0.177407665286786 2.67698443222439e-10 NA NA NA hsa-miR-96-5p GNG12 3.24596558166606 1.92296159041707e-98 -1.00662202078145 1.13075382846906e-21 TargetScan -0.177675699622518 2.20766570176543e-17 NA NA NA hsa-miR-100-5p GRB2 -1.89453309391092 5.00588682382388e-51 0.639828372471576 5.6864573011903e-23 miRNAWalker2_validate -0.156661486141178 3.5519143452408e-21 NA NA NA hsa-miR-378a-3p GRB2 -1.79882978380301 1.05005373951733e-38 0.639828372471576 5.6864573011903e-23 miRNAWalker2_validate;MirTarget;miRNATAP -0.128042134644829 1.17944311772052e-16 NA NA NA hsa-miR-378c GRB2 -1.79697571999492 1.07363220292403e-41 0.639828372471576 5.6864573011903e-23 MirTarget;miRNATAP -0.126006904107165 4.99041375742704e-15 NA NA NA hsa-let-7a-5p HRAS -0.210286642041636 0.0072546234707717 0.871315771945202 9.54693368299171e-15 miRNAWalker2_validate;miRTarBase -0.156144832596741 0.00194814074250424 20607356;23134218;18344688;20033209;19323605 Transfection of let-7 miRNA reduced expression of pan-RAS N-RAS and K-RAS in the glioblastoma cells;MicroRNA let 7a inhibits the proliferation and invasion of nonsmall cell lung cancer cell line 95D by regulating K Ras and HMGA2 gene expression; K-RAS and HMGA2 mRNA levels were significantly higher in the let-7a overexpressed group than those in the let-7a inhibited group p < 0.05; However the protein levels of K-RAS and HMGA2 were significantly lower in the let-7a overexpressed group than those in the let-7a inhibited group p < 0.05; We suppose that let-7a inhibits the proliferation and invasion of the cell line 95D by regulating the translation of K-RAS and HMGA2 mRNA not the transcription of the mRNA itself;Using an established orthotopic mouse lung cancer model we show that intranasal let-7 administration reduces tumor formation in vivo in the lungs of animals expressing a G12D activating mutation for the K-ras oncogene;k-Ras and c-Myc two key oncogenes in lung cancer have been found to be targeted by let-7 in vitro; The aim of the present study is to determine the effect of let-7a a member of let-7 family on the growth of lung cancer in vivo and to investigate whether let-7-induced suppression of k-Ras and c-Myc is involved in lung cancer; Overexpression of let-7a can inhibit the growth of lung cancer transplanted subcutaneously in nude mice by suppression of k-Ras and c-Myc;Because let-7 microRNA targets the K-ras oncogene we aimed to characterize let-7 expression and function in PDAC in vitro and in vivo; Restoring let-7 levels in cancer-derived cell lines strongly inhibits cell proliferation K-ras expression and mitogen-activated protein kinase activation but fails to impede tumor growth progression after intratumoral gene transfer or after implantation of Capan-1 cells stably overexpressing let-7 microRNA ;;;;progression glioblastoma;lung squamous cell cancer;lung cancer;lung cancer;pancreatic cancer hsa-let-7b-5p HRAS -0.54215483448257 7.21347617597858e-08 0.871315771945202 9.54693368299171e-15 miRTarBase -0.245640732103343 1.64072414700874e-10 20607356;20881268;18344688;20033209;19323605 Transfection of let-7 miRNA reduced expression of pan-RAS N-RAS and K-RAS in the glioblastoma cells;On the basis of these data we suggest that the downregulation of let-7b and let-7e targeting K-ras and the upregulation of miR-17* a CRC marker could be considered as candidate molecular markers of cetuximab resistance;Using an established orthotopic mouse lung cancer model we show that intranasal let-7 administration reduces tumor formation in vivo in the lungs of animals expressing a G12D activating mutation for the K-ras oncogene;k-Ras and c-Myc two key oncogenes in lung cancer have been found to be targeted by let-7 in vitro; The aim of the present study is to determine the effect of let-7a a member of let-7 family on the growth of lung cancer in vivo and to investigate whether let-7-induced suppression of k-Ras and c-Myc is involved in lung cancer;Because let-7 microRNA targets the K-ras oncogene we aimed to characterize let-7 expression and function in PDAC in vitro and in vivo; Restoring let-7 levels in cancer-derived cell lines strongly inhibits cell proliferation K-ras expression and mitogen-activated protein kinase activation but fails to impede tumor growth progression after intratumoral gene transfer or after implantation of Capan-1 cells stably overexpressing let-7 microRNA ;drug resistance;;;progression glioblastoma;colorectal cancer;lung cancer;lung cancer;pancreatic cancer hsa-miR-143-3p HRAS -1.23248181631499 4.74160976678504e-28 0.871315771945202 9.54693368299171e-15 miRNAWalker2_validate;miRTarBase -0.13171025180707 9.59955008801748e-05 21276449 The Evi1 microRNA 143 K Ras axis in colon cancer colon cancer hsa-miR-766-3p HRAS 0.496790679032227 8.22686414022553e-05 0.871315771945202 9.54693368299171e-15 MirTarget -0.107283016649624 0.000532542374235056 NA NA NA hsa-miR-125a-5p HSPA1A -0.635694700253268 3.6703235721638e-11 0.650265491816123 1.60469692704019e-09 miRanda -0.110598396139594 0.00410538659594579 NA NA NA hsa-miR-146a-5p HSPA1A 0.102405752365098 0.486975378688068 0.650265491816123 1.60469692704019e-09 miRNAWalker2_validate -0.111071511727877 1.0988067435835e-05 NA NA NA hsa-miR-335-5p HSPA1A -2.61355235628987 2.6462884165886e-51 0.650265491816123 1.60469692704019e-09 miRNAWalker2_validate -0.106074197289326 1.29519353600891e-07 NA NA NA hsa-let-7b-5p HSPA1B -0.54215483448257 7.21347617597858e-08 0.487404167271908 3.10487024426853e-07 miRNAWalker2_validate -0.115193235024296 0.000389906123305959 NA NA NA hsa-miR-10b-5p HSPA1B -2.10996264627796 7.36811595736367e-72 0.487404167271908 3.10487024426853e-07 miRNAWalker2_validate -0.186926841902028 1.16037013127619e-13 NA NA NA hsa-miR-125b-5p HSPA1B -1.94393269763542 2.78180543229264e-58 0.487404167271908 3.10487024426853e-07 miRNAWalker2_validate -0.190455328857887 2.27088038037002e-14 NA NA NA hsa-miR-22-3p HSPA1B -0.505819481364718 1.90494905330622e-13 0.487404167271908 3.10487024426853e-07 miRNAWalker2_validate -0.124293625628995 0.00907700544970058 NA NA NA hsa-miR-34c-5p HSPA1B -0.0896438810345765 0.557016551646841 0.487404167271908 3.10487024426853e-07 miRanda;miRNATAP -0.10296398168385 1.74597675166807e-06 NA NA NA hsa-miR-215-5p HSPA2 -1.35643065897947 2.3180023440257e-20 0.395066833217632 0.0221152535314528 miRNAWalker2_validate -0.185911823762757 2.32718316247645e-06 NA NA NA hsa-miR-217 HSPA2 -0.616728851115349 8.64977119332241e-05 0.395066833217632 0.0221152535314528 miRanda -0.101250621627192 0.00708316619569834 NA NA NA hsa-miR-339-5p HSPA2 -0.211548290465418 0.0685885445822389 0.395066833217632 0.0221152535314528 miRanda -0.131837538800332 0.00991807655697385 NA NA NA hsa-miR-500a-3p HSPA2 0.139523673241448 0.185528510741158 0.395066833217632 0.0221152535314528 miRNATAP -0.441646847255014 1.77678606323452e-15 NA NA NA hsa-miR-26a-5p HSPA8 -0.481180084102235 1.82368246174758e-10 0.408688935330554 2.12830173898248e-07 miRNAWalker2_validate -0.391939203554511 1.37216021957359e-29 NA NA NA hsa-miR-146b-5p IKBKB 0.631041661167954 6.20366593452965e-08 0.273066826249678 0.00234033685126725 miRanda -0.152908526927625 4.45729055656516e-09 NA NA NA hsa-miR-151a-3p IKBKB 0.3530403796941 3.45015092968892e-05 0.273066826249678 0.00234033685126725 miRNAWalker2_validate -0.109349947297392 0.0025250144404732 NA NA NA hsa-miR-28-5p IKBKB -0.14267073663385 0.0497619246260571 0.273066826249678 0.00234033685126725 miRanda -0.249159305195741 4.36298401628208e-09 NA NA NA hsa-miR-324-5p IKBKB 0.211552647440779 0.139408130311654 0.273066826249678 0.00234033685126725 miRanda -0.118429787871439 3.07201825932054e-08 NA NA NA hsa-miR-330-5p IKBKB 0.626063225953928 3.42215028606779e-09 0.273066826249678 0.00234033685126725 miRanda -0.115452535316074 6.19261343388698e-05 NA NA NA hsa-miR-590-3p IKBKB 1.27438512890514 1.03164723481469e-23 0.273066826249678 0.00234033685126725 miRanda;mirMAP -0.100127823485223 4.7662908944255e-05 NA NA NA hsa-miR-125a-5p IKBKG -0.635694700253268 3.6703235721638e-11 0.490716396303581 1.1441359682473e-11 miRanda -0.228007302003838 2.38576015741085e-19 NA NA NA hsa-miR-140-5p IKBKG -0.755971041589807 9.68060922934542e-14 0.490716396303581 1.1441359682473e-11 miRanda -0.125852887257061 2.14634764656029e-07 NA NA NA hsa-miR-3607-3p IKBKG 0.00697875745616461 0.972073275173643 0.490716396303581 1.1441359682473e-11 mirMAP -0.123479124494569 5.75170407705992e-24 NA NA NA hsa-miR-130b-5p IL1R1 1.0573161199584 2.55177349228739e-12 -1.34299021321699 3.96277058038665e-24 mirMAP -0.134792075843703 9.62989300771142e-06 NA NA NA hsa-miR-17-3p IL1R1 0.721439431208839 7.95900548819742e-10 -1.34299021321699 3.96277058038665e-24 mirMAP -0.264058620225795 1.43612311566876e-11 NA NA NA hsa-miR-192-5p IL1R1 1.33366224451777 9.5116159697107e-29 -1.34299021321699 3.96277058038665e-24 miRNAWalker2_validate -0.29199087319334 3.85990473776844e-15 NA NA NA hsa-miR-30d-3p IL1R1 0.264544633563642 0.00755023189129747 -1.34299021321699 3.96277058038665e-24 mirMAP -0.226015646684785 1.68705773637213e-06 NA NA NA hsa-miR-590-3p IL1R1 1.27438512890514 1.03164723481469e-23 -1.34299021321699 3.96277058038665e-24 miRanda;miRNATAP -0.200131921987377 7.85936325921516e-08 NA NA NA hsa-miR-330-5p JMJD7-PLA2G4B 0.626063225953928 3.42215028606779e-09 -0.263856973511927 0.00391874846287315 miRNATAP -0.231724089285207 1.24674326027351e-15 NA NA NA hsa-miR-141-3p JUN 2.99777540204168 1.26370498493024e-78 -1.36309173493779 4.05020743854001e-29 miRNATAP -0.26513026030347 4.33514873445987e-29 NA NA NA hsa-miR-155-5p JUN 1.09766314984151 4.55650930885814e-15 -1.36309173493779 4.05020743854001e-29 miRNAWalker2_validate;miRTarBase -0.151050894850655 5.76726631886013e-07 23693020 In the present study we demonstrated for the first time that activation of RAGE by S100P regulates oncogenic microRNA-155 miR-155 expression through Activator Protein-1 AP-1 stimulation in colon cancer cells colon cancer hsa-miR-16-5p JUN 0.46835991343556 1.91125356547776e-06 -1.36309173493779 4.05020743854001e-29 miRNAWalker2_validate -0.336111932326481 7.47849859844435e-15 NA NA NA hsa-miR-200a-3p JUN 2.55218480823434 2.96135446816238e-51 -1.36309173493779 4.05020743854001e-29 miRNATAP -0.179081800592841 4.16743748553287e-14 NA NA NA hsa-miR-200b-3p JUN 2.11744072703209 1.66710572104191e-43 -1.36309173493779 4.05020743854001e-29 MirTarget;TargetScan -0.16460620647419 5.28647088864828e-10 NA NA NA hsa-miR-200c-3p JUN 2.07038651806183 6.84613386286599e-51 -1.36309173493779 4.05020743854001e-29 MirTarget -0.273188681953389 1.78966606345752e-21 NA NA NA hsa-miR-32-5p JUN 1.38676603945192 2.29428299685976e-34 -1.36309173493779 4.05020743854001e-29 miRNATAP -0.263951179853313 2.73587232573327e-13 NA NA NA hsa-miR-342-3p JUN 1.21944481975657 6.81914373001202e-19 -1.36309173493779 4.05020743854001e-29 miRNAWalker2_validate -0.199604605467411 5.91888161762324e-11 NA NA NA hsa-miR-429 JUN 2.84108892259147 3.88520896426515e-64 -1.36309173493779 4.05020743854001e-29 MirTarget;PITA;miRanda;miRNATAP -0.17100165827497 4.02284319393828e-13 NA NA NA hsa-miR-455-3p JUN 0.678392920628872 0.000327758844555877 -1.36309173493779 4.05020743854001e-29 miRNATAP -0.147720631567845 5.98195601818343e-11 NA NA NA hsa-miR-590-3p JUN 1.27438512890514 1.03164723481469e-23 -1.36309173493779 4.05020743854001e-29 miRanda -0.306481168731635 1.59764946185952e-19 NA NA NA hsa-miR-92a-3p JUN -0.342420481092807 0.000732275969501111 -1.36309173493779 4.05020743854001e-29 miRNATAP -0.138285339206201 0.00119119178853874 NA NA NA hsa-miR-92b-3p JUN 1.30248132773644 9.42428674470985e-25 -1.36309173493779 4.05020743854001e-29 miRNATAP -0.135248670230231 4.27496884553493e-05 NA NA NA hsa-miR-93-5p JUN 1.01788600209314 1.24312921618126e-21 -1.36309173493779 4.05020743854001e-29 miRNAWalker2_validate -0.216264935663652 4.08318210776355e-08 NA NA NA hsa-miR-186-5p JUND -0.426987301460247 1.04129380549315e-05 -0.393103146575286 8.20715845474359e-05 miRNAWalker2_validate -0.260220307114409 9.50423191232725e-14 NA NA NA hsa-miR-589-3p JUND 0.0263457630961427 0.866577983997705 -0.393103146575286 8.20715845474359e-05 MirTarget -0.160605027568062 3.9128110608734e-13 NA NA NA hsa-miR-140-3p KRAS -1.25844395244141 5.29222651039892e-33 0.46818988509622 3.00748217900386e-10 MirTarget -0.245149449217664 6.89860831179258e-27 NA NA NA hsa-miR-143-3p KRAS -1.23248181631499 4.74160976678504e-28 0.46818988509622 3.00748217900386e-10 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.124135749972866 1.80319700574441e-08 22804917;27725862;19137007;26581910;23173124;26824186;21197560 In KRAS mutated tumours increased miR-200b and decreased miR-143 expression were associated with a good PFS;The expression of miR-143 is often down-regulated and it might play an important role by targeting KRAS in colorectal cancer CRC; Dual-luciferase reporter assays were performed to validate whether KRAS was regulated by miR-143; Dual-luciferase assays indicated that KRAS was a direct target of miR-143 as subsequently demonstrated by qPCR and western blot analysis showing that infection of SW480 cells with Ad-ZD55-miR-143 resulted in the down-regulation of KRAS at both mRNA and protein levels;Role of miR 143 targeting KRAS in colorectal tumorigenesis; In particular among a panel of presumed targets generated by in silico analysis that may interact with these aberrantly expressed miRNAs KRAS oncogene has been further experimentally validated as the target of miR-143; First an inverse correlation between KRAS protein and miR-143 in vivo was found; Second KRAS expression in Lovo cells was significantly abolished by treatment with miR-143 mimic whereas miR-143 inhibitor increased KRAS protein level; Third luciferase reporter assay confirmed that miR-143 directly recognize the 3'-untranslated region of KRAS transcripts; Finally inhibition of KRAS expression by miR-143 inhibits constitutive phosphorylation of ERK1/2; Taken together the present study provides the first evidences that miR-143 is significant in suppressing colorectal cancer cell growth through inhibition of KRAS translation;MicroRNA 143 replenishment re sensitizes colorectal cancer cells harboring mutant but not wild type KRAS to paclitaxel treatment; Our results showed that miR-143 but not let-7b increased sensitization of KRAS mutant tumor cells to paclitaxel; Furthermore transfection of miR-143 but not let-7b mimic negatively regulated the expression of mutant but not wild-type KRAS; Combination of miR-143 mimic and paclitaxel induced the onset of apoptosis and reverted in vitro metastatic properties migration and invasion in KRAS mutant tumor cells; MiR-143 thus can be used as a chemosensitizer for the treatment of KRAS mutant tumors and warrants further investigations in in vitro and pre-clinical in vivo models;In turn the level of miR-143 in CRC cells decreasing the amount of MACC1 metastasis-associated in colon cancer-1 and oncogenic KRAS protein may be utilized as a prognostic marker;Stable miR-143 or miR-145 overexpression increased cell sensitivity to cetuximab resulting in a significant increase of cetuximab-mediated ADCC independently of KRAS status;miR 143 decreases prostate cancer cells proliferation and migration and enhances their sensitivity to docetaxel through suppression of KRAS; The expression level of miR-143 and its target gene KRAS were measured by realtime PCR and western blotting respectively; Our results revealed an inverse correlation of expression between miR-143 and KRAS protein in prostate cancer samples Pearson's correlation scatter plots: R = -0.707 P < 0.05; These findings suggest that miR-143 plays an important role in prostate cancer proliferation migration and chemosensitivity by suppressing KRAS and subsequent inactivation of MAPK pathway which provides a potential development of a new approach for the treatment of prostate cancer ;;tumorigenesis;;metastasis;; colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colon cancer;prostate cancer hsa-miR-195-3p KRAS -1.49582726452416 6.53261924105147e-40 0.46818988509622 3.00748217900386e-10 mirMAP -0.144084535908296 1.9114583860958e-11 NA NA NA hsa-miR-30d-5p KRAS -0.247082219011045 0.00406717930063148 0.46818988509622 3.00748217900386e-10 mirMAP;miRNATAP -0.13177346252977 1.09256098608436e-05 NA NA NA hsa-miR-542-3p KRAS 0.568822103820889 8.5699075257651e-07 0.46818988509622 3.00748217900386e-10 miRanda -0.123003016716369 2.33095765684339e-08 NA NA NA hsa-miR-101-3p MAP2K1 -0.126035286271986 0.145997832808138 -0.185433389862149 0.000727711407664528 miRNAWalker2_validate -0.158307400181186 2.0108100169932e-13 NA NA NA hsa-miR-181a-5p MAP2K1 0.635863607630183 6.72486918157744e-11 -0.185433389862149 0.000727711407664528 miRNAWalker2_validate -0.103686555340189 5.16890556712928e-08 NA NA NA hsa-miR-361-5p MAP2K1 -0.0996867547900457 0.095428250126326 -0.185433389862149 0.000727711407664528 miRanda -0.121080950243885 0.000149537457617663 NA NA NA hsa-miR-542-3p MAP2K1 0.568822103820889 8.5699075257651e-07 -0.185433389862149 0.000727711407664528 miRanda -0.113613468340007 1.26995828232255e-12 NA NA NA hsa-let-7b-5p MAP2K2 -0.54215483448257 7.21347617597858e-08 0.61941089334837 7.64917587016439e-15 miRNAWalker2_validate -0.171851964586426 2.69292025446759e-10 NA NA NA hsa-let-7b-3p MAP2K3 -0.778498268330274 1.04357662300776e-10 -0.147252768703865 0.0438058263552004 MirTarget;miRNATAP -0.133045038200244 6.2773121994202e-11 NA NA NA hsa-miR-25-3p MAP2K4 -0.00546790775985073 0.944061771389468 -0.220647015187585 0.00691779367927608 miRNATAP -0.23828840862771 3.23384047073026e-11 NA NA NA hsa-miR-27a-3p MAP2K4 0.388496361379095 1.42373532086331e-05 -0.220647015187585 0.00691779367927608 miRNATAP -0.205664450684214 3.2695548450062e-11 27594411;24556602 Androgen induced miR 27A acted as a tumor suppressor by targeting MAP2K4 and mediated prostate cancer progression;MicroRNA 27a promotes proliferation migration and invasion by targeting MAP2K4 in human osteosarcoma cells; In this study three biological programs were used to predict whether MAP2K4 was a target of miR-27a; Thus MAP2K4 is a potential target of miR-27a and can be directly regulated by miR-27a; After transfection of the miR-27a inhibitor into the MG63 cells the level of phospho-JNK1 and phospho-p38 increased by 25% and 29% respectively along with the up-regulation of MAP2K4 protein; This is the first study showing that miR-27a can function as an oncogene by targeting MAP2K4 in the osteosarcoma MG63 cell line; Inhibition of miR-27a increases MAP2K4 expression which in turn inhibits cell proliferation and migration through the JNK/p38 signaling pathway in MG63 cells progression; prostate cancer;sarcoma hsa-miR-27b-3p MAP2K4 -0.0796803270437447 0.410503155574393 -0.220647015187585 0.00691779367927608 miRNATAP -0.164900985321039 1.12856188627898e-08 NA NA NA hsa-miR-32-5p MAP2K4 1.38676603945192 2.29428299685976e-34 -0.220647015187585 0.00691779367927608 miRNATAP -0.123640504611593 1.59016943179027e-07 NA NA NA hsa-miR-374a-3p MAP2K4 0.34122393953022 2.28714105382856e-05 -0.220647015187585 0.00691779367927608 mirMAP -0.226080249038704 5.86858672054893e-11 NA NA NA hsa-miR-374b-5p MAP2K4 -0.466781429946153 1.17238311619116e-08 -0.220647015187585 0.00691779367927608 miRNATAP -0.200185650984664 3.59810136469139e-09 NA NA NA hsa-miR-542-3p MAP2K4 0.568822103820889 8.5699075257651e-07 -0.220647015187585 0.00691779367927608 PITA;miRanda -0.110782351542386 4.10491410826527e-06 NA NA NA hsa-miR-92a-3p MAP2K4 -0.342420481092807 0.000732275969501111 -0.220647015187585 0.00691779367927608 miRNATAP -0.130595748708446 2.13649714390319e-06 NA NA NA hsa-miR-146b-5p MAP2K5 0.631041661167954 6.20366593452965e-08 -0.43716537294647 8.05712553474393e-17 miRanda -0.102511963097713 3.10162737887723e-11 NA NA NA hsa-miR-590-3p MAP2K5 1.27438512890514 1.03164723481469e-23 -0.43716537294647 8.05712553474393e-17 miRanda -0.136911601205228 1.04338626551923e-21 NA NA NA hsa-miR-342-3p MAP2K6 1.21944481975657 6.81914373001202e-19 -1.13554802248427 3.68383482181241e-19 miRanda -0.135623662091665 1.79118376872771e-05 NA NA NA hsa-miR-125a-5p MAP2K7 -0.635694700253268 3.6703235721638e-11 0.139691176196235 0.0272367482773536 miRNAWalker2_validate;PITA;miRanda;miRNATAP -0.127904700455212 8.45212671241737e-09 NA NA NA hsa-miR-125b-5p MAP2K7 -1.94393269763542 2.78180543229264e-58 0.139691176196235 0.0272367482773536 miRNATAP -0.123174346532377 7.045606121122e-14 27226726 miR 125b inhibited epithelial mesenchymal transition of triple negative breast cancer by targeting MAP2K7; Upregulation of MAP2K7 in miR-125b-overexpressing Hs578T cells partly rescued the migration and invasion suppression of miR-125b; Furthermore MAP2K7 was overexpressed in TNBC samples compared with normal tissues and negatively correlated with miR-125b expression; In light of these findings miR-125b emerged as a tumor suppressor in TNBC by targeting MAP2K7 to inhibit EMT breast cancer hsa-miR-1271-5p MAP2K7 -1.08290983583835 3.85149976357318e-12 0.139691176196235 0.0272367482773536 mirMAP -0.101662430480549 9.16609179723631e-14 NA NA NA hsa-miR-148b-3p MAP2K7 1.0552576751879 1.6679285705231e-29 0.139691176196235 0.0272367482773536 mirMAP -0.103352675221667 3.727674507691e-06 NA NA NA hsa-miR-2355-5p MAP2K7 -0.221733044425126 0.0231054202524677 0.139691176196235 0.0272367482773536 mirMAP -0.16515848521989 5.36093828958094e-14 NA NA NA hsa-miR-331-3p MAP2K7 0.74441480542886 1.17071235477799e-07 0.139691176196235 0.0272367482773536 PITA;miRNATAP -0.114161679453077 3.84486827220987e-14 NA NA NA hsa-let-7d-5p MAP3K1 0.410958462607207 6.07808182756787e-06 -0.163521491329447 0.167268025811007 miRNATAP -0.226027442785467 3.65751997211353e-07 NA NA NA hsa-let-7i-5p MAP3K1 -0.333419326258177 3.56960810786801e-08 -0.163521491329447 0.167268025811007 miRNATAP -0.23744742722582 0.000436444258409537 NA NA NA hsa-miR-106b-5p MAP3K1 1.22477789913175 2.31787213143326e-32 -0.163521491329447 0.167268025811007 miRNATAP -0.384974614993792 1.0045377090923e-25 NA NA NA hsa-miR-17-5p MAP3K1 0.599531757298529 1.07318660415906e-05 -0.163521491329447 0.167268025811007 TargetScan;miRNATAP -0.310104556968725 3.91907919004493e-27 NA NA NA hsa-miR-186-5p MAP3K1 -0.426987301460247 1.04129380549315e-05 -0.163521491329447 0.167268025811007 miRNATAP -0.253077873014471 1.0879444559356e-09 NA NA NA hsa-miR-18a-5p MAP3K1 0.969066793715868 1.69069796425892e-08 -0.163521491329447 0.167268025811007 miRNATAP -0.316610440339497 2.14317799336319e-46 NA NA NA hsa-miR-193a-3p MAP3K1 0.310617999804917 0.00477640270974957 -0.163521491329447 0.167268025811007 PITA;miRanda -0.127721648566783 0.000530888625023873 NA NA NA hsa-miR-19a-3p MAP3K1 0.817507952171848 3.76285090469625e-08 -0.163521491329447 0.167268025811007 miRNATAP -0.235745066021849 6.42725569797822e-19 NA NA NA hsa-miR-19b-3p MAP3K1 0.139124391010031 0.255658553872934 -0.163521491329447 0.167268025811007 miRNATAP -0.210088718195511 1.71710812666064e-10 NA NA NA hsa-miR-20a-5p MAP3K1 0.44979911120222 0.000602386964327228 -0.163521491329447 0.167268025811007 miRNATAP -0.321445896731414 7.01265550703887e-27 NA NA NA hsa-miR-338-3p MAP3K1 0.0799903526884966 0.575137668326679 -0.163521491329447 0.167268025811007 miRanda -0.148565945701495 1.52804170403501e-07 NA NA NA hsa-miR-339-5p MAP3K1 -0.211548290465418 0.0685885445822389 -0.163521491329447 0.167268025811007 miRanda -0.130296015671691 0.00019225115462755 NA NA NA hsa-miR-423-3p MAP3K1 0.338351552541003 0.000947983901628776 -0.163521491329447 0.167268025811007 miRNAWalker2_validate -0.177022276770259 7.61573013155125e-06 NA NA NA hsa-miR-455-3p MAP3K1 0.678392920628872 0.000327758844555877 -0.163521491329447 0.167268025811007 PITA;miRNATAP -0.109905081507907 2.42093880306182e-07 NA NA NA hsa-miR-590-3p MAP3K1 1.27438512890514 1.03164723481469e-23 -0.163521491329447 0.167268025811007 PITA;miRanda;mirMAP -0.190862786902978 3.29431603222709e-09 NA NA NA hsa-miR-590-5p MAP3K1 0.746515607868274 8.51300479640125e-09 -0.163521491329447 0.167268025811007 PITA;miRanda;miRNATAP -0.247925212460521 4.86337696373428e-16 NA NA NA hsa-miR-9-5p MAP3K1 0.734772328078424 0.00261982843636383 -0.163521491329447 0.167268025811007 miRNATAP -0.14428718873248 5.67486049474687e-19 NA NA NA hsa-miR-93-5p MAP3K1 1.01788600209314 1.24312921618126e-21 -0.163521491329447 0.167268025811007 miRNATAP -0.387746485239839 6.04898341920525e-27 NA NA NA hsa-miR-125a-5p MAP3K11 -0.635694700253268 3.6703235721638e-11 0.295956668578404 1.92022980376064e-05 PITA;miRanda;miRNATAP -0.208877092985834 4.70871654248418e-18 NA NA NA hsa-miR-125b-5p MAP3K11 -1.94393269763542 2.78180543229264e-58 0.295956668578404 1.92022980376064e-05 miRNATAP -0.128315711210625 1.42018928052251e-12 24635082 Expression of the miRNA miR-125b and serine/threonine kinase mixed lineage kinase MLK3 was assessed in primary malignant melanoma tissues and several melanoma cell lines by quantitative reverse transcription PCR; The effect of MLK3 and miR-125b on cell proliferation was evaluated by MTS assay and cell invasion was evaluated by Transwell invasion assays; Targeting of MLK3 by miR-125b was evaluated using luciferase reporter assay and western blotting; Using bioinformatics we identified MLK3 as one potential target of miR-125b; miRNA transfection and luciferase assay confirmed that MLK3 was regulated by miR-125b at both the transcriptional and translational levels; MLK3 is a direct target of miR-125b malignant trasformation melanoma hsa-miR-143-5p MAP3K11 -1.08813426434718 6.46387834906802e-10 0.295956668578404 1.92022980376064e-05 miRNATAP -0.115367393813087 1.29909586231416e-18 NA NA NA hsa-miR-199a-5p MAP3K11 -0.314703593105081 0.00909304983051124 0.295956668578404 1.92022980376064e-05 miRNAWalker2_validate;miRTarBase;PITA;miRanda;miRNATAP -0.112620727242619 9.20870693414466e-09 26717044;26885275 Overexpression of miR 199a 5p decreases esophageal cancer cell proliferation through repression of mitogen activated protein kinase kinase kinase 11 MAP3K11; MiR-199a-5p is predicted to bind mitogen-activated protein kinase kinase kinase 11 MAP3K11 mRNA with high affinity; Forced expression of miR-199a-5p in these cells leads to a decrease in the mRNA and protein levels of MAP3K11 due to decreased MAP3K11 mRNA stability; A direct binding interaction between miR-199a-5p and MAP3K11 mRNA is demonstrated using biotin pull-down assays and heterologous luciferase reporter constructs and confirmed by mutational analysis; These findings suggest that miR-199a-5p acts as a tumor suppressor in esophageal cancer cells and that its downregulation contributes to enhanced cellular proliferation by targeting MAP3K11;Further investigation reported that MLK3 was a direct target of miR-199a-5p; Moreover the expression level of miR-199a-5p was conversely correlated with MLK3 in bladder cancerous cells; In addition reintroduction of MLK3 was identified to promote the proliferation and inhibit the apoptotic rate of cells which have been altered by miR-199a-5p through activating the NF-κB pathway ; esophageal cancer;bladder cancer hsa-miR-491-5p MAP3K11 -1.04307210952796 1.14586501470398e-15 0.295956668578404 1.92022980376064e-05 miRanda -0.147777973015974 9.64530625404376e-17 NA NA NA hsa-miR-106a-5p MAP3K12 0.574594373206545 0.000145868284001732 0.000401227302291751 0.99702138751066 MirTarget -0.179644432596702 5.89653285287624e-14 NA NA NA hsa-miR-106b-5p MAP3K12 1.22477789913175 2.31787213143326e-32 0.000401227302291751 0.99702138751066 MirTarget -0.290783135183762 5.48436837640914e-18 NA NA NA hsa-miR-130a-3p MAP3K12 -1.15024914519431 6.51290317952496e-19 0.000401227302291751 0.99702138751066 MirTarget;miRNATAP -0.160093448716746 6.78213412742952e-09 NA NA NA hsa-miR-130b-3p MAP3K12 1.38122163823846 1.00932179737836e-26 0.000401227302291751 0.99702138751066 MirTarget;miRNATAP -0.271313212647082 1.12152699032173e-23 NA NA NA hsa-miR-140-5p MAP3K12 -0.755971041589807 9.68060922934542e-14 0.000401227302291751 0.99702138751066 miRanda -0.26660537661619 4.35275604188887e-14 NA NA NA hsa-miR-143-5p MAP3K12 -1.08813426434718 6.46387834906802e-10 0.000401227302291751 0.99702138751066 MirTarget;miRNATAP -0.112780181708085 3.96515144973058e-08 NA NA NA hsa-miR-17-5p MAP3K12 0.599531757298529 1.07318660415906e-05 0.000401227302291751 0.99702138751066 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.322283290500137 7.11451135445355e-36 NA NA NA hsa-miR-186-5p MAP3K12 -0.426987301460247 1.04129380549315e-05 0.000401227302291751 0.99702138751066 MirTarget -0.444175041760165 3.82943435627693e-34 NA NA NA hsa-miR-19a-3p MAP3K12 0.817507952171848 3.76285090469625e-08 0.000401227302291751 0.99702138751066 MirTarget -0.223711617749487 1.20637239882546e-20 NA NA NA hsa-miR-19b-3p MAP3K12 0.139124391010031 0.255658553872934 0.000401227302291751 0.99702138751066 MirTarget -0.258125353016626 2.35079983484182e-18 NA NA NA hsa-miR-20a-5p MAP3K12 0.44979911120222 0.000602386964327228 0.000401227302291751 0.99702138751066 miRNAWalker2_validate;miRTarBase;MirTarget -0.205948937747095 9.2159412566019e-14 NA NA NA hsa-miR-22-3p MAP3K12 -0.505819481364718 1.90494905330622e-13 0.000401227302291751 0.99702138751066 MirTarget -0.194087884465857 0.000267484800405072 NA NA NA hsa-miR-27a-3p MAP3K12 0.388496361379095 1.42373532086331e-05 0.000401227302291751 0.99702138751066 miRNATAP -0.296411493948551 2.91331164135371e-13 NA NA NA hsa-miR-27b-3p MAP3K12 -0.0796803270437447 0.410503155574393 0.000401227302291751 0.99702138751066 miRNATAP -0.142354789382235 0.000189913807792354 NA NA NA hsa-miR-301a-3p MAP3K12 1.32170168375632 2.12280368957514e-15 0.000401227302291751 0.99702138751066 MirTarget;miRNATAP -0.163543345325316 3.0953171350708e-14 NA NA NA hsa-miR-30e-5p MAP3K12 0.293491764699475 0.000372291967271834 0.000401227302291751 0.99702138751066 MirTarget -0.409705733141508 8.32930926430052e-21 NA NA NA hsa-miR-324-3p MAP3K12 0.404877731996915 0.000340036423920834 0.000401227302291751 0.99702138751066 MirTarget -0.283931471722403 5.26139513983153e-19 NA NA NA hsa-miR-590-3p MAP3K12 1.27438512890514 1.03164723481469e-23 0.000401227302291751 0.99702138751066 miRanda -0.313676311945879 4.22370033619891e-28 NA NA NA hsa-miR-671-3p MAP3K12 0.35164403523086 0.00407349401262717 0.000401227302291751 0.99702138751066 PITA -0.213193458151032 8.49187285398559e-13 NA NA NA hsa-miR-93-5p MAP3K12 1.01788600209314 1.24312921618126e-21 0.000401227302291751 0.99702138751066 MirTarget -0.255003275391893 1.78498315558922e-14 NA NA NA hsa-miR-101-3p MAP3K13 -0.126035286271986 0.145997832808138 -0.143115944600636 0.27821448586369 MirTarget;miRNATAP -0.140527236663429 0.00746320371679239 NA NA NA hsa-miR-106b-5p MAP3K13 1.22477789913175 2.31787213143326e-32 -0.143115944600636 0.27821448586369 miRNATAP -0.1198678701998 0.00446681628441864 NA NA NA hsa-miR-181a-5p MAP3K13 0.635863607630183 6.72486918157744e-11 -0.143115944600636 0.27821448586369 mirMAP -0.145512313880266 0.00157972613383151 NA NA NA hsa-miR-20a-5p MAP3K13 0.44979911120222 0.000602386964327228 -0.143115944600636 0.27821448586369 miRNATAP -0.188876706274703 3.37812777034402e-08 NA NA NA hsa-miR-320a MAP3K13 -0.287921276129346 0.00141693637596294 -0.143115944600636 0.27821448586369 mirMAP -0.169711553851779 0.000731679311606292 NA NA NA hsa-miR-3913-5p MAP3K13 0.71890413546147 2.61153227160465e-13 -0.143115944600636 0.27821448586369 mirMAP -0.135282068980821 0.00300632254712987 NA NA NA hsa-miR-542-3p MAP3K13 0.568822103820889 8.5699075257651e-07 -0.143115944600636 0.27821448586369 MirTarget -0.10987094372456 0.00481838547182098 NA NA NA hsa-miR-93-5p MAP3K13 1.01788600209314 1.24312921618126e-21 -0.143115944600636 0.27821448586369 miRNAWalker2_validate;miRNATAP -0.174007041117719 2.60545607627547e-05 NA NA NA hsa-miR-331-3p MAP3K14 0.74441480542886 1.17071235477799e-07 -0.382347455234441 4.23425075991379e-06 MirTarget -0.148338380185048 1.0581376256797e-13 NA NA NA hsa-miR-345-5p MAP3K14 0.639728356429512 0.00013070715719672 -0.382347455234441 4.23425075991379e-06 MirTarget -0.119214954004009 1.4484437317052e-12 NA NA NA hsa-miR-874-3p MAP3K14 -0.513415443180424 1.49285755109414e-06 -0.382347455234441 4.23425075991379e-06 MirTarget -0.132080548476967 7.02111806746594e-07 NA NA NA hsa-miR-101-3p MAP3K2 -0.126035286271986 0.145997832808138 -0.231552627390085 0.0197411056315087 MirTarget -0.177778207660126 6.4380627565255e-06 NA NA NA hsa-miR-106b-5p MAP3K2 1.22477789913175 2.31787213143326e-32 -0.231552627390085 0.0197411056315087 MirTarget;miRNATAP -0.239527414872011 1.91272893467726e-14 NA NA NA hsa-miR-181a-5p MAP3K2 0.635863607630183 6.72486918157744e-11 -0.231552627390085 0.0197411056315087 mirMAP -0.247639042516789 4.8705280163965e-13 NA NA NA hsa-miR-181b-5p MAP3K2 1.22749257795094 1.21998198830919e-27 -0.231552627390085 0.0197411056315087 mirMAP -0.208671069593092 5.39435739818906e-13 NA NA NA hsa-miR-181c-5p MAP3K2 0.574847839298605 4.51287502066478e-07 -0.231552627390085 0.0197411056315087 mirMAP -0.189699386490183 1.23778001033825e-10 NA NA NA hsa-miR-19a-3p MAP3K2 0.817507952171848 3.76285090469625e-08 -0.231552627390085 0.0197411056315087 MirTarget;mirMAP;miRNATAP -0.119463251652124 1.26759961596498e-07 NA NA NA hsa-miR-19b-3p MAP3K2 0.139124391010031 0.255658553872934 -0.231552627390085 0.0197411056315087 MirTarget;mirMAP;miRNATAP -0.124652698055499 7.28078827569227e-06 NA NA NA hsa-miR-20a-5p MAP3K2 0.44979911120222 0.000602386964327228 -0.231552627390085 0.0197411056315087 MirTarget;miRNATAP -0.255571942382276 4.08739740912086e-24 NA NA NA hsa-miR-21-5p MAP3K2 2.32007501846389 3.08394781855554e-137 -0.231552627390085 0.0197411056315087 miRNAWalker2_validate;mirMAP -0.117694966119235 0.000139697716851587 NA NA NA hsa-miR-221-3p MAP3K2 -0.317970198201501 0.00910855267413448 -0.231552627390085 0.0197411056315087 MirTarget -0.122038096644395 1.18578693839484e-05 NA NA NA hsa-miR-26a-5p MAP3K2 -0.481180084102235 1.82368246174758e-10 -0.231552627390085 0.0197411056315087 miRNAWalker2_validate;miRTarBase;mirMAP;miRNATAP -0.249251282514959 2.52892170417058e-08 NA NA NA hsa-miR-320a MAP3K2 -0.287921276129346 0.00141693637596294 -0.231552627390085 0.0197411056315087 miRanda;mirMAP -0.140636197484446 0.000200223112735656 NA NA NA hsa-miR-340-5p MAP3K2 1.0857159627596 4.94471062546756e-24 -0.231552627390085 0.0197411056315087 MirTarget;mirMAP -0.236910583006213 7.23872399266098e-15 NA NA NA hsa-miR-374a-5p MAP3K2 -0.239709888246804 0.00309819667153627 -0.231552627390085 0.0197411056315087 MirTarget -0.185415351040063 1.08203001370786e-05 NA NA NA hsa-miR-3913-5p MAP3K2 0.71890413546147 2.61153227160465e-13 -0.231552627390085 0.0197411056315087 miRNATAP -0.249445672174692 1.81544455938967e-13 NA NA NA hsa-miR-455-5p MAP3K2 0.284641224662773 0.0357572339594277 -0.231552627390085 0.0197411056315087 miRNATAP -0.176778083606606 1.10288331223083e-12 NA NA NA hsa-miR-93-5p MAP3K2 1.01788600209314 1.24312921618126e-21 -0.231552627390085 0.0197411056315087 MirTarget;miRNATAP -0.248369883382793 6.35632977105162e-16 NA NA NA hsa-miR-106b-5p MAP3K3 1.22477789913175 2.31787213143326e-32 -0.734541340963792 2.63872799634068e-34 MirTarget;miRNATAP -0.170728200663524 3.28602912783938e-18 NA NA NA hsa-miR-141-3p MAP3K3 2.99777540204168 1.26370498493024e-78 -0.734541340963792 2.63872799634068e-34 miRNATAP -0.165901727144462 2.60406258844207e-47 NA NA NA hsa-miR-15a-5p MAP3K3 0.812445324157528 4.50263417099822e-20 -0.734541340963792 2.63872799634068e-34 MirTarget;miRNATAP -0.14118449639202 2.26501961954578e-09 NA NA NA hsa-miR-181a-5p MAP3K3 0.635863607630183 6.72486918157744e-11 -0.734541340963792 2.63872799634068e-34 MirTarget;miRNATAP -0.108143031695775 6.77119723332027e-07 NA NA NA hsa-miR-181b-5p MAP3K3 1.22749257795094 1.21998198830919e-27 -0.734541340963792 2.63872799634068e-34 MirTarget;miRNATAP -0.125883960844978 5.34411360251018e-12 NA NA NA hsa-miR-181c-5p MAP3K3 0.574847839298605 4.51287502066478e-07 -0.734541340963792 2.63872799634068e-34 MirTarget;miRNATAP -0.115905271147182 4.58773058590452e-10 NA NA NA hsa-miR-181d-5p MAP3K3 0.782618466877349 1.2821116358212e-09 -0.734541340963792 2.63872799634068e-34 MirTarget -0.115472658761802 1.40981230517464e-12 NA NA NA hsa-miR-182-5p MAP3K3 2.36408084103818 2.60011457600281e-72 -0.734541340963792 2.63872799634068e-34 miRNATAP -0.174662362093805 3.2021058811911e-34 NA NA NA hsa-miR-200a-3p MAP3K3 2.55218480823434 2.96135446816238e-51 -0.734541340963792 2.63872799634068e-34 miRNATAP -0.135063200600891 7.18528329824784e-32 NA NA NA hsa-miR-429 MAP3K3 2.84108892259147 3.88520896426515e-64 -0.734541340963792 2.63872799634068e-34 miRNATAP -0.134843971111218 3.2531482493031e-32 NA NA NA hsa-miR-93-5p MAP3K3 1.01788600209314 1.24312921618126e-21 -0.734541340963792 2.63872799634068e-34 MirTarget;miRNATAP -0.160498027832055 1.09215948052099e-16 NA NA NA hsa-miR-96-5p MAP3K3 3.24596558166606 1.92296159041707e-98 -0.734541340963792 2.63872799634068e-34 MirTarget;TargetScan;miRNATAP -0.161945661566676 2.81030045385988e-43 NA NA NA hsa-miR-107 MAP3K4 0.678998026350662 2.56224148930538e-16 -0.409370614866226 3.01293825668498e-13 miRanda -0.123381406126255 9.02156666730562e-08 NA NA NA hsa-miR-15a-5p MAP3K4 0.812445324157528 4.50263417099822e-20 -0.409370614866226 3.01293825668498e-13 miRNATAP -0.132909986145834 5.35155559950516e-10 NA NA NA hsa-miR-106b-5p MAP3K5 1.22477789913175 2.31787213143326e-32 -1.14088601125645 1.72781404202526e-25 miRNATAP -0.243740085642228 7.82679748909641e-12 NA NA NA hsa-miR-200b-3p MAP3K5 2.11744072703209 1.66710572104191e-43 -1.14088601125645 1.72781404202526e-25 TargetScan -0.203449016952416 4.00360408784291e-18 NA NA NA hsa-miR-20a-5p MAP3K5 0.44979911120222 0.000602386964327228 -1.14088601125645 1.72781404202526e-25 miRNATAP -0.12255133168485 2.98165333047376e-05 NA NA NA hsa-miR-30a-5p MAP3K5 -0.392489994825279 0.00954894667761676 -1.14088601125645 1.72781404202526e-25 miRNATAP -0.117261776543982 3.89527729687589e-06 NA NA NA hsa-miR-30c-5p MAP3K5 -0.393222674580066 8.06961465717306e-05 -1.14088601125645 1.72781404202526e-25 miRNATAP -0.101952290279721 0.00856067766415811 NA NA NA hsa-miR-30d-5p MAP3K5 -0.247082219011045 0.00406717930063148 -1.14088601125645 1.72781404202526e-25 miRNATAP -0.130463174746757 0.00386641351541823 NA NA NA hsa-miR-429 MAP3K5 2.84108892259147 3.88520896426515e-64 -1.14088601125645 1.72781404202526e-25 PITA;miRanda;miRNATAP -0.186993561689497 3.71856058490676e-19 NA NA NA hsa-miR-93-5p MAP3K5 1.01788600209314 1.24312921618126e-21 -1.14088601125645 1.72781404202526e-25 miRNATAP -0.259432108883113 1.19925945168051e-13 NA NA NA hsa-miR-103a-3p MAP3K7 0.610673390034345 1.63113920514646e-12 -0.143716552142434 0.0267403723117399 miRNAWalker2_validate -0.184281845409368 2.38036238656993e-13 NA NA NA hsa-let-7a-3p MAP3K8 0.466622567891891 3.70886257943079e-07 -1.2874759183903 1.74321074366661e-26 MirTarget -0.224424344267259 1.2825693481559e-06 NA NA NA hsa-let-7g-3p MAP3K8 0.5854327663695 0.000371711766083627 -1.2874759183903 1.74321074366661e-26 MirTarget -0.10760155056318 3.18496079975434e-05 NA NA NA hsa-miR-106b-5p MAP3K8 1.22477789913175 2.31787213143326e-32 -1.2874759183903 1.74321074366661e-26 MirTarget;miRNATAP -0.148295412689426 0.000196793191277802 NA NA NA hsa-miR-128-3p MAP3K8 0.90296715955238 9.925204823863e-23 -1.2874759183903 1.74321074366661e-26 MirTarget -0.156937321050053 0.00055226583272107 NA NA NA hsa-miR-181a-5p MAP3K8 0.635863607630183 6.72486918157744e-11 -1.2874759183903 1.74321074366661e-26 MirTarget -0.156593826708062 0.000323093224261249 NA NA NA hsa-miR-181b-5p MAP3K8 1.22749257795094 1.21998198830919e-27 -1.2874759183903 1.74321074366661e-26 MirTarget -0.201957949176776 3.34904751860882e-08 NA NA NA hsa-miR-375 MAP3K8 2.09893673049766 1.68351780396203e-16 -1.2874759183903 1.74321074366661e-26 miRNAWalker2_validate -0.164213371246878 1.02420593264318e-24 NA NA NA hsa-miR-429 MAP3K8 2.84108892259147 3.88520896426515e-64 -1.2874759183903 1.74321074366661e-26 PITA;miRanda -0.164071361638277 2.14043089054769e-12 NA NA NA hsa-miR-590-3p MAP3K8 1.27438512890514 1.03164723481469e-23 -1.2874759183903 1.74321074366661e-26 miRanda;mirMAP -0.111653995775446 0.00112385259937563 NA NA NA hsa-miR-590-5p MAP3K8 0.746515607868274 8.51300479640125e-09 -1.2874759183903 1.74321074366661e-26 PITA;miRanda -0.128951000035324 8.06039825822545e-05 NA NA NA hsa-miR-93-5p MAP3K8 1.01788600209314 1.24312921618126e-21 -1.2874759183903 1.74321074366661e-26 MirTarget;miRNATAP -0.173824550870182 8.92199887176378e-06 NA NA NA hsa-let-7i-5p MAP4K3 -0.333419326258177 3.56960810786801e-08 -0.207683535177747 0.00251574295917218 MirTarget;miRNATAP -0.241344706486217 5.60298675930292e-10 NA NA NA hsa-miR-155-5p MAP4K3 1.09766314984151 4.55650930885814e-15 -0.207683535177747 0.00251574295917218 MirTarget -0.114377067975298 2.70196577084248e-12 NA NA NA hsa-miR-340-5p MAP4K3 1.0857159627596 4.94471062546756e-24 -0.207683535177747 0.00251574295917218 MirTarget -0.141914021069627 2.02308293303953e-11 NA NA NA hsa-miR-374a-5p MAP4K3 -0.239709888246804 0.00309819667153627 -0.207683535177747 0.00251574295917218 MirTarget;mirMAP -0.148018766645916 3.65801151048859e-07 NA NA NA hsa-miR-98-5p MAP4K3 0.656336869298973 9.03113188590466e-15 -0.207683535177747 0.00251574295917218 MirTarget -0.116455319798151 2.25185172059652e-05 NA NA NA hsa-let-7a-5p MAP4K4 -0.210286642041636 0.0072546234707717 -0.308580581654411 0.00014813484298229 MirTarget;TargetScan -0.182576400524269 3.27672133618795e-07 NA NA NA hsa-miR-141-3p MAP4K4 2.99777540204168 1.26370498493024e-78 -0.308580581654411 0.00014813484298229 TargetScan -0.134453890562392 4.95116248896509e-18 24013097 To understand how miR-141 mediates the phenotype of pancreatic cancer cells a bioinformatics tool was used to identify MAP4K4 as a potential target of miR-141; The Dual-Luciferase reporter gene assay showed that miR-141 binds directly to the 3'-untranslated region 3'UTR of MAP4K4 to inhibit MAP4K4 expression; Western blot and quantitative real-time PCR qRT-PCR analyses revealed that MAP4K4 expression was inversely correlated with miR-141 expression both in pancreatic cancer samples and cell lines; In a nude mouse xenograft model both overexpression of miR-141 and knockdown of MAP4K4 significantly repressed pancreatic cancer cell growth; Therefore we conclude that miR-141 targets MAP4K4 acts as a tumor suppressor in pancreatic cancer cells and may serve as a novel therapeutic agent for miRNA-based pancreatic cancer therapy pancreatic cancer hsa-miR-182-5p MAP4K4 2.36408084103818 2.60011457600281e-72 -0.308580581654411 0.00014813484298229 MirTarget -0.147351716984953 1.33660645444299e-14 NA NA NA hsa-miR-200b-3p MAP4K4 2.11744072703209 1.66710572104191e-43 -0.308580581654411 0.00014813484298229 TargetScan -0.169304068185926 7.98066390013092e-24 NA NA NA hsa-miR-29b-3p MAP4K4 0.438847962603729 6.46722433236121e-05 -0.308580581654411 0.00014813484298229 miRNATAP -0.194411136833782 8.02514331040552e-15 NA NA NA hsa-miR-29c-3p MAP4K4 -0.0652732378039769 0.563774115756922 -0.308580581654411 0.00014813484298229 miRNATAP -0.308750097827958 6.14405720130319e-39 NA NA NA hsa-miR-429 MAP4K4 2.84108892259147 3.88520896426515e-64 -0.308580581654411 0.00014813484298229 PITA;miRanda;miRNATAP -0.109688597683786 6.15288697896005e-13 NA NA NA hsa-miR-96-5p MAP4K4 3.24596558166606 1.92296159041707e-98 -0.308580581654411 0.00014813484298229 TargetScan -0.10479933354992 4.99971379946185e-11 NA NA NA hsa-miR-29c-3p MAPK1 -0.0652732378039769 0.563774115756922 -0.282469104608855 4.85723866828359e-06 mirMAP -0.107930467813368 8.09848447187363e-09 NA NA NA hsa-miR-361-5p MAPK1 -0.0996867547900457 0.095428250126326 -0.282469104608855 4.85723866828359e-06 PITA;miRanda;mirMAP -0.263780179525808 1.39108568009728e-13 NA NA NA hsa-miR-3913-5p MAPK1 0.71890413546147 2.61153227160465e-13 -0.282469104608855 4.85723866828359e-06 mirMAP -0.145979254174869 5.54224263447113e-12 NA NA NA hsa-miR-660-5p MAPK1 0.406910761707485 0.000156175371762464 -0.282469104608855 4.85723866828359e-06 mirMAP -0.144747929471906 1.05117786154161e-13 NA NA NA hsa-miR-130b-3p MAPK10 1.38122163823846 1.00932179737836e-26 -2.40438462003309 4.2516538591888e-32 miRNATAP -0.311198542431805 1.15998229401123e-08 NA NA NA hsa-miR-19a-3p MAPK10 0.817507952171848 3.76285090469625e-08 -2.40438462003309 4.2516538591888e-32 miRNATAP -0.222702615462015 4.17842244233184e-06 NA NA NA hsa-miR-19b-3p MAPK10 0.139124391010031 0.255658553872934 -2.40438462003309 4.2516538591888e-32 miRNATAP -0.182028621380633 0.00223666160802019 NA NA NA hsa-miR-29b-3p MAPK10 0.438847962603729 6.46722433236121e-05 -2.40438462003309 4.2516538591888e-32 miRNATAP -0.214951327451731 0.00114851870928561 24767251 The percentage of positive myeloid cell leukemia sequence 1 ATG9A and MAPK10 protein expression and low miR-29b mRNA expression were significantly higher in cases with clinical stage III and IV ovarian cancer than in cases with clinical stage II ovarian cancer; Univariate Kaplan-Meier analysis showed a negative correlation between MAPK10 or ATG9A protein expression and overall as well as progression-free survival whereas a positive correlation was observed between miR-29b mRNA expression and overall as well as progression-free survival; Multivariate Cox regression analysis showed that elevated MAPK10 or ATG9A protein and lowered miR-29b mRNA expression in ovarian carcinoma was an independent poor prognostic predictor; Our study suggested that miR-29b mRNA MAPK10 protein expression and ATG9A protein expression are closely related to chemosensitivity of ovarian carcinoma staging;progression;poor survival ovarian cancer hsa-miR-301a-3p MAPK10 1.32170168375632 2.12280368957514e-15 -2.40438462003309 4.2516538591888e-32 miRNATAP -0.20354840914367 2.22032173676851e-06 NA NA NA hsa-miR-30d-3p MAPK10 0.264544633563642 0.00755023189129747 -2.40438462003309 4.2516538591888e-32 mirMAP -0.192664485965265 0.00899807954985931 NA NA NA hsa-miR-330-3p MAPK10 0.432728362037032 0.00041335506960812 -2.40438462003309 4.2516538591888e-32 PITA;miRNATAP -0.240537820613709 6.0605250152691e-05 NA NA NA hsa-miR-429 MAPK10 2.84108892259147 3.88520896426515e-64 -2.40438462003309 4.2516538591888e-32 miRNATAP -0.366481358214565 1.02092652001284e-20 NA NA NA hsa-miR-454-3p MAPK10 1.28177672191095 6.84024979484587e-21 -2.40438462003309 4.2516538591888e-32 miRNATAP -0.269274577449595 2.23366460726875e-07 NA NA NA hsa-miR-455-5p MAPK10 0.284641224662773 0.0357572339594277 -2.40438462003309 4.2516538591888e-32 miRanda -0.2052531701295 0.000129116493384105 NA NA NA hsa-miR-590-3p MAPK10 1.27438512890514 1.03164723481469e-23 -2.40438462003309 4.2516538591888e-32 miRanda;mirMAP -0.323164263319335 2.39879463887196e-08 NA NA NA hsa-miR-590-5p MAPK10 0.746515607868274 8.51300479640125e-09 -2.40438462003309 4.2516538591888e-32 PITA;miRanda;miRNATAP -0.208756960356003 0.000174508852265274 NA NA NA hsa-miR-125a-5p MAPK12 -0.635694700253268 3.6703235721638e-11 0.115659878295223 0.383319017822158 miRNATAP -0.202093170321227 1.58081689346245e-05 NA NA NA hsa-miR-335-5p MAPK13 -2.61355235628987 2.6462884165886e-51 1.49058465220791 9.34310856898705e-63 mirMAP -0.153169246178821 2.74313989203629e-18 NA NA NA hsa-miR-21-5p MAPK14 2.32007501846389 3.08394781855554e-137 -0.284160448012007 6.36269794096921e-09 mirMAP -0.113666961486213 5.43544541750221e-14 NA NA NA hsa-miR-361-5p MAPK14 -0.0996867547900457 0.095428250126326 -0.284160448012007 6.36269794096921e-09 miRanda -0.112257209621889 8.80745814280997e-05 NA NA NA hsa-miR-197-3p MAPK3 -0.526589453596294 3.61594599437195e-06 -0.0806112580526674 0.201094437565328 miRNATAP -0.106370513582673 1.47526386613596e-08 NA NA NA hsa-miR-330-5p MAPK7 0.626063225953928 3.42215028606779e-09 -0.0179281009146832 0.754367808771292 miRanda -0.10080122901497 3.29223775972861e-08 NA NA NA hsa-miR-107 MAPK8 0.678998026350662 2.56224148930538e-16 -0.297398434625207 0.00492168724399827 miRNATAP -0.17791631045835 3.75913999690967e-05 NA NA NA hsa-miR-140-3p MAPK8 -1.25844395244141 5.29222651039892e-33 -0.297398434625207 0.00492168724399827 miRNAWalker2_validate -0.18488366577202 2.13922359684877e-08 NA NA NA hsa-miR-214-3p MAPK8 -0.523705501275844 0.000211299789901139 -0.297398434625207 0.00492168724399827 miRNAWalker2_validate -0.131663145030191 2.77448993612092e-07 19859982 HeLa cells that stably overexpress miR-214 downregulate the expression of MEK3 and JNK1 at both mRNA and protein levels; Further investigation revealed that miR-214 regulates the expression of MEK3 and JNK1 by targeting the 3'UTRs of these genes; Collectively these results suggest that miR-214 negatively regulates HeLa cell proliferation by targeting the noncoding regions of MEK3 and JNK1 mRNAs cervical and endocervical cancer hsa-miR-22-5p MAPK8 0.238328801322329 0.0377496760295305 -0.297398434625207 0.00492168724399827 mirMAP -0.111645018994966 0.000421521825972328 NA NA NA hsa-miR-361-5p MAPK8 -0.0996867547900457 0.095428250126326 -0.297398434625207 0.00492168724399827 PITA;miRanda;mirMAP -0.36263548128247 3.21553639920568e-09 NA NA NA hsa-miR-191-3p MAPK8IP1 0.925247604011397 2.59555142048271e-07 -0.0168668510841377 0.897348900767282 miRNAWalker2_validate -0.10131783642082 6.64364530202967e-05 NA NA NA hsa-miR-24-3p MAPK8IP1 -0.120123317289941 0.21432376743243 -0.0168668510841377 0.897348900767282 MirTarget;miRNATAP -0.339614852076351 1.34880256118183e-13 NA NA NA hsa-miR-330-5p MAPK8IP1 0.626063225953928 3.42215028606779e-09 -0.0168668510841377 0.897348900767282 miRanda -0.165460937944867 7.90898797424296e-05 NA NA NA hsa-miR-505-5p MAPK8IP1 -0.842640534241897 4.43022473091907e-09 -0.0168668510841377 0.897348900767282 MirTarget -0.172523389623125 2.11538182598633e-08 NA NA NA hsa-miR-125b-2-3p MAPK8IP2 -1.92374904783012 2.30779527653582e-38 2.4681485681513 1.70865425093233e-31 mirMAP -0.538785101256277 7.39054878744941e-31 NA NA NA hsa-miR-125b-5p MAPK8IP2 -1.94393269763542 2.78180543229264e-58 2.4681485681513 1.70865425093233e-31 mirMAP -0.649280521563951 4.06420077312955e-31 NA NA NA hsa-miR-130a-3p MAPK8IP2 -1.15024914519431 6.51290317952496e-19 2.4681485681513 1.70865425093233e-31 mirMAP -0.481572210986163 6.98428856481368e-18 NA NA NA hsa-miR-150-5p MAPK8IP2 -0.832049526091211 3.45299201139224e-05 2.4681485681513 1.70865425093233e-31 mirMAP -0.184636982098902 6.60471580787698e-07 NA NA NA hsa-miR-195-5p MAPK8IP2 -1.47508108420708 2.20685847368258e-38 2.4681485681513 1.70865425093233e-31 mirMAP -0.299833382584574 1.92477179326268e-06 NA NA NA hsa-miR-214-3p MAPK8IP2 -0.523705501275844 0.000211299789901139 2.4681485681513 1.70865425093233e-31 mirMAP -0.418003315642038 2.01377067184472e-15 NA NA NA hsa-miR-22-5p MAPK8IP2 0.238328801322329 0.0377496760295305 2.4681485681513 1.70865425093233e-31 mirMAP -0.245392273222251 0.000188428913127602 NA NA NA hsa-miR-24-3p MAPK8IP2 -0.120123317289941 0.21432376743243 2.4681485681513 1.70865425093233e-31 mirMAP -0.428790934959349 3.53995993355977e-08 NA NA NA hsa-miR-363-3p MAPK8IP2 -0.0402062060863897 0.833024617256265 2.4681485681513 1.70865425093233e-31 mirMAP -0.159016383335593 5.74060733411535e-05 NA NA NA hsa-miR-432-5p MAPK8IP2 -1.27705834793565 1.47191322114198e-20 2.4681485681513 1.70865425093233e-31 mirMAP -0.492906256875487 6.81949803972231e-21 NA NA NA hsa-miR-497-5p MAPK8IP2 -1.4667331575679 5.49909921822638e-36 2.4681485681513 1.70865425093233e-31 mirMAP -0.270921269792498 1.0440010688695e-05 NA NA NA hsa-miR-10b-5p MAPK8IP3 -2.10996264627796 7.36811595736367e-72 0.532750388429446 8.5941775911158e-07 mirMAP -0.124157461990045 1.76943842485894e-05 NA NA NA hsa-miR-22-3p MAPK8IP3 -0.505819481364718 1.90494905330622e-13 0.532750388429446 8.5941775911158e-07 MirTarget -0.433517330463164 3.5899886248563e-16 NA NA NA hsa-miR-30b-3p MAPK8IP3 -0.536462824497982 2.41814659272548e-05 0.532750388429446 8.5941775911158e-07 mirMAP -0.103973285759802 0.00041123775615424 NA NA NA hsa-miR-324-3p MAPK8IP3 0.404877731996915 0.000340036423920834 0.532750388429446 8.5941775911158e-07 MirTarget -0.20859984184555 1.79650475382634e-10 NA NA NA hsa-miR-326 MAPK8IP3 -1.54449030848141 1.04703417845594e-17 0.532750388429446 8.5941775911158e-07 mirMAP -0.214574967646561 9.32117376209734e-28 NA NA NA hsa-miR-330-5p MAPK8IP3 0.626063225953928 3.42215028606779e-09 0.532750388429446 8.5941775911158e-07 mirMAP -0.162939137685789 2.99853203407126e-06 NA NA NA hsa-miR-539-5p MAPK8IP3 -1.28530285996605 1.62620330363951e-14 0.532750388429446 8.5941775911158e-07 mirMAP -0.241812993877637 5.11434962228949e-30 NA NA NA hsa-miR-766-3p MAPK8IP3 0.496790679032227 8.22686414022553e-05 0.532750388429446 8.5941775911158e-07 mirMAP -0.228292915940052 3.99330098144211e-15 NA NA NA hsa-let-7i-5p MAPK9 -0.333419326258177 3.56960810786801e-08 0.291220683716117 6.17961998679004e-06 miRNATAP -0.306833929478603 2.50065627421339e-17 NA NA NA hsa-miR-20a-5p MAPK9 0.44979911120222 0.000602386964327228 0.291220683716117 6.17961998679004e-06 miRNAWalker2_validate;miRNATAP -0.149791797617831 1.16802726117118e-19 NA NA NA hsa-miR-361-5p MAPK9 -0.0996867547900457 0.095428250126326 0.291220683716117 6.17961998679004e-06 miRanda -0.302539307267532 3.19615101156316e-16 NA NA NA hsa-miR-374a-5p MAPK9 -0.239709888246804 0.00309819667153627 0.291220683716117 6.17961998679004e-06 mirMAP -0.208569547789819 1.38505915980085e-14 NA NA NA hsa-miR-374b-5p MAPK9 -0.466781429946153 1.17238311619116e-08 0.291220683716117 6.17961998679004e-06 mirMAP -0.162602292754305 1.32462729456077e-09 NA NA NA hsa-miR-92a-3p MAPK9 -0.342420481092807 0.000732275969501111 0.291220683716117 6.17961998679004e-06 miRNAWalker2_validate -0.159802962706798 1.32672396914361e-13 NA NA NA hsa-miR-125b-5p MAPKAPK2 -1.94393269763542 2.78180543229264e-58 1.0251614728704 1.42861021749993e-41 MirTarget;mirMAP -0.18586611487326 2.23783505848978e-19 NA NA NA hsa-miR-495-3p MAPKAPK2 -1.67685437612894 1.70634429769052e-34 1.0251614728704 1.42861021749993e-41 mirMAP -0.142926123975903 4.80846007926985e-14 NA NA NA hsa-miR-1271-5p MAPT -1.08290983583835 3.85149976357318e-12 -0.125705967593898 0.64555550336755 mirMAP -0.356892668944988 1.80100955291692e-09 NA NA NA hsa-miR-132-3p MAPT -0.0365213889238607 0.668598301088667 -0.125705967593898 0.64555550336755 MirTarget -0.442056965841922 6.17526022344575e-05 NA NA NA hsa-miR-140-3p MAPT -1.25844395244141 5.29222651039892e-33 -0.125705967593898 0.64555550336755 mirMAP -0.534315383125933 3.23397603064239e-10 NA NA NA hsa-miR-146b-3p MAPT -0.260891807886908 0.0211838235241739 -0.125705967593898 0.64555550336755 miRNATAP -0.777432246691656 6.98578093980296e-22 NA NA NA hsa-miR-146b-5p MAPT 0.631041661167954 6.20366593452965e-08 -0.125705967593898 0.64555550336755 PITA;miRNATAP -0.835044269820334 3.90382930358291e-27 NA NA NA hsa-miR-150-5p MAPT -0.832049526091211 3.45299201139224e-05 -0.125705967593898 0.64555550336755 mirMAP -0.254809852352586 3.16706082237023e-08 NA NA NA hsa-miR-17-3p MAPT 0.721439431208839 7.95900548819742e-10 -0.125705967593898 0.64555550336755 mirMAP -0.907188557018318 9.33289199336475e-33 NA NA NA hsa-miR-181a-5p MAPT 0.635863607630183 6.72486918157744e-11 -0.125705967593898 0.64555550336755 miRNATAP -0.433386494323195 5.16020356881357e-06 NA NA NA hsa-miR-181b-5p MAPT 1.22749257795094 1.21998198830919e-27 -0.125705967593898 0.64555550336755 miRNATAP -0.538093782052545 1.44906611773212e-11 NA NA NA hsa-miR-212-3p MAPT 0.24081906669865 0.0571447155653209 -0.125705967593898 0.64555550336755 MirTarget -0.516724966116714 3.67510844840074e-12 NA NA NA hsa-miR-24-3p MAPT -0.120123317289941 0.21432376743243 -0.125705967593898 0.64555550336755 mirMAP -1.07262676674646 3.13635093094976e-30 NA NA NA hsa-miR-27a-3p MAPT 0.388496361379095 1.42373532086331e-05 -0.125705967593898 0.64555550336755 miRNATAP -0.887495940157438 5.62096681028266e-18 NA NA NA hsa-miR-27b-3p MAPT -0.0796803270437447 0.410503155574393 -0.125705967593898 0.64555550336755 miRNATAP -0.497491322275073 2.69455181442262e-07 NA NA NA hsa-miR-27b-5p MAPT 0.478244809913032 2.28657237923291e-06 -0.125705967593898 0.64555550336755 mirMAP -0.558444012789245 1.08427650813845e-09 NA NA NA hsa-miR-28-5p MAPT -0.14267073663385 0.0497619246260571 -0.125705967593898 0.64555550336755 mirMAP -1.05719797085297 1.32790959528459e-16 NA NA NA hsa-miR-29a-5p MAPT 0.334183773952055 0.00445137265870197 -0.125705967593898 0.64555550336755 MirTarget;miRNATAP -0.539674238732501 8.79215790829553e-12 NA NA NA hsa-miR-320b MAPT 0.412787504747938 0.00113457276903985 -0.125705967593898 0.64555550336755 miRanda -0.347203415430207 2.60187962612857e-06 NA NA NA hsa-miR-361-5p MAPT -0.0996867547900457 0.095428250126326 -0.125705967593898 0.64555550336755 miRanda -0.614288217371122 0.000111862775962441 NA NA NA hsa-miR-484 MAPT 0.349444060004737 0.00154491249625173 -0.125705967593898 0.64555550336755 mirMAP -0.420029045310662 6.67968749329013e-07 NA NA NA hsa-miR-505-5p MAPT -0.842640534241897 4.43022473091907e-09 -0.125705967593898 0.64555550336755 MirTarget -0.750821456081803 1.95924663922257e-33 NA NA NA hsa-miR-582-3p MAPT 0.126152488945932 0.333088461939587 -0.125705967593898 0.64555550336755 PITA;miRNATAP -0.451124762157128 2.51964133450341e-10 NA NA NA hsa-miR-589-3p MAPT 0.0263457630961427 0.866577983997705 -0.125705967593898 0.64555550336755 mirMAP -0.544819726498102 8.60596903818403e-20 NA NA NA hsa-miR-589-5p MAPT 0.367182541239722 1.67804815542873e-05 -0.125705967593898 0.64555550336755 mirMAP -0.828872158558218 2.05477179127849e-14 NA NA NA hsa-miR-766-3p MAPT 0.496790679032227 8.22686414022553e-05 -0.125705967593898 0.64555550336755 MirTarget -0.739775556928591 8.98632971186051e-25 NA NA NA hsa-miR-93-3p MAPT 0.627759242044891 3.62527588304617e-06 -0.125705967593898 0.64555550336755 mirMAP -0.592931732703939 1.41043240189295e-18 NA NA NA hsa-miR-28-5p MAX -0.14267073663385 0.0497619246260571 0.189520873245771 3.41527676404311e-05 miRanda -0.126434947821145 4.87379608519139e-09 NA NA NA hsa-let-7a-3p MEF2C 0.466622567891891 3.70886257943079e-07 -1.3628193091141 3.63471865869307e-46 MirTarget;miRNATAP -0.16548607197299 1.08470988876985e-05 NA NA NA hsa-miR-107 MEF2C 0.678998026350662 2.56224148930538e-16 -1.3628193091141 3.63471865869307e-46 miRanda -0.28940850428767 1.40757479153585e-12 NA NA NA hsa-miR-130b-5p MEF2C 1.0573161199584 2.55177349228739e-12 -1.3628193091141 3.63471865869307e-46 MirTarget;miRNATAP -0.108712679053942 1.44994498282299e-06 NA NA NA hsa-miR-182-5p MEF2C 2.36408084103818 2.60011457600281e-72 -1.3628193091141 3.63471865869307e-46 MirTarget;miRNATAP -0.300723563792995 4.32642954345554e-39 NA NA NA hsa-miR-183-5p MEF2C 2.95681814393872 1.09965777344285e-92 -1.3628193091141 3.63471865869307e-46 MirTarget;miRNATAP -0.304597174462637 1.85002963697187e-52 NA NA NA hsa-miR-18a-5p MEF2C 0.969066793715868 1.69069796425892e-08 -1.3628193091141 3.63471865869307e-46 MirTarget -0.127566112747227 1.28918194375564e-10 NA NA NA hsa-miR-194-5p MEF2C 0.467781870340114 1.0386810618625e-07 -1.3628193091141 3.63471865869307e-46 miRNATAP -0.239864455000625 8.16622655421491e-10 NA NA NA hsa-miR-19a-3p MEF2C 0.817507952171848 3.76285090469625e-08 -1.3628193091141 3.63471865869307e-46 miRNATAP -0.176087579666608 1.19118685814738e-14 NA NA NA hsa-miR-19b-3p MEF2C 0.139124391010031 0.255658553872934 -1.3628193091141 3.63471865869307e-46 miRNATAP -0.132895247463557 2.6359055404439e-06 NA NA NA hsa-miR-200c-5p MEF2C 1.72523090857052 4.04399802119594e-33 -1.3628193091141 3.63471865869307e-46 MirTarget -0.260314239644814 1.3530551956641e-29 NA NA NA hsa-miR-203a-3p MEF2C 1.67084394806148 6.06522273352132e-14 -1.3628193091141 3.63471865869307e-46 MirTarget -0.128156321887287 1.53815639692546e-17 NA NA NA hsa-miR-21-5p MEF2C 2.32007501846389 3.08394781855554e-137 -1.3628193091141 3.63471865869307e-46 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.349922334680877 1.22856305351208e-30 NA NA NA hsa-miR-30d-3p MEF2C 0.264544633563642 0.00755023189129747 -1.3628193091141 3.63471865869307e-46 MirTarget;miRNATAP -0.166688140873718 1.92585854992162e-06 NA NA NA hsa-miR-324-3p MEF2C 0.404877731996915 0.000340036423920834 -1.3628193091141 3.63471865869307e-46 miRNATAP -0.169155401334933 2.86884452711424e-08 NA NA NA hsa-miR-331-5p MEF2C 0.682437632502949 4.10871642662371e-11 -1.3628193091141 3.63471865869307e-46 PITA -0.220828207388833 2.27305400974549e-11 NA NA NA hsa-miR-3613-5p MEF2C 1.11067990676844 4.33424951743633e-21 -1.3628193091141 3.63471865869307e-46 MirTarget;miRNATAP -0.130717519201622 5.22473857587581e-06 NA NA NA hsa-miR-425-5p MEF2C 0.719898949241718 6.01079610190374e-08 -1.3628193091141 3.63471865869307e-46 MirTarget;miRNATAP -0.154475790790347 1.91092887552441e-09 NA NA NA hsa-miR-429 MEF2C 2.84108892259147 3.88520896426515e-64 -1.3628193091141 3.63471865869307e-46 miRanda;miRNATAP -0.268097792284511 4.40553586167332e-50 NA NA NA hsa-miR-590-3p MEF2C 1.27438512890514 1.03164723481469e-23 -1.3628193091141 3.63471865869307e-46 mirMAP -0.148396053659386 7.88756831947677e-08 NA NA NA hsa-miR-590-5p MEF2C 0.746515607868274 8.51300479640125e-09 -1.3628193091141 3.63471865869307e-46 MirTarget;PITA;miRanda;miRNATAP -0.135223142310521 3.11744878473778e-07 NA NA NA hsa-miR-92a-3p MEF2C -0.342420481092807 0.000732275969501111 -1.3628193091141 3.63471865869307e-46 miRNAWalker2_validate -0.136275062585738 6.70515483640626e-05 NA NA NA hsa-miR-96-5p MEF2C 3.24596558166606 1.92296159041707e-98 -1.3628193091141 3.63471865869307e-46 miRNATAP -0.28116413771846 1.32376660175131e-50 NA NA NA hsa-miR-17-5p MKNK2 0.599531757298529 1.07318660415906e-05 0.0137795715779827 0.872309059382961 MirTarget;TargetScan;miRNATAP -0.160887023535462 2.76312801167811e-14 NA NA NA hsa-miR-20a-5p MKNK2 0.44979911120222 0.000602386964327228 0.0137795715779827 0.872309059382961 MirTarget;miRNATAP -0.100125847981658 6.89107118087187e-06 NA NA NA hsa-miR-21-5p MKNK2 2.32007501846389 3.08394781855554e-137 0.0137795715779827 0.872309059382961 miRNAWalker2_validate -0.112053298236543 2.51599581837069e-05 NA NA NA hsa-miR-27a-3p MKNK2 0.388496361379095 1.42373532086331e-05 0.0137795715779827 0.872309059382961 miRNAWalker2_validate;MirTarget;miRNATAP -0.134178650737207 4.13766667314125e-05 NA NA NA hsa-miR-27b-3p MKNK2 -0.0796803270437447 0.410503155574393 0.0137795715779827 0.872309059382961 MirTarget;miRNATAP -0.182269972370325 1.60605390308252e-09 NA NA NA hsa-miR-324-3p MKNK2 0.404877731996915 0.000340036423920834 0.0137795715779827 0.872309059382961 miRNAWalker2_validate -0.171635197343602 2.31053190233907e-11 NA NA NA hsa-miR-370-3p MKNK2 -0.678485107633497 3.08223718122071e-07 0.0137795715779827 0.872309059382961 MirTarget -0.100280192914736 5.28510585822082e-06 NA NA NA hsa-miR-576-5p MKNK2 0.0649387707567879 0.588791966096287 0.0137795715779827 0.872309059382961 mirMAP -0.150276494084243 5.97970976846092e-10 NA NA NA hsa-miR-874-3p MKNK2 -0.513415443180424 1.49285755109414e-06 0.0137795715779827 0.872309059382961 MirTarget -0.130331188184928 1.81496089329327e-06 NA NA NA hsa-miR-92a-3p MKNK2 -0.342420481092807 0.000732275969501111 0.0137795715779827 0.872309059382961 miRNAWalker2_validate -0.238226359870774 5.65087343247316e-17 NA NA NA hsa-miR-98-5p MKNK2 0.656336869298973 9.03113188590466e-15 0.0137795715779827 0.872309059382961 miRNAWalker2_validate -0.144529481387907 2.3879324774737e-05 NA NA NA hsa-let-7e-5p MRAS 0.261471269338985 0.00191077095550257 -2.33160876190743 5.5050134478505e-74 mirMAP -0.192389755360429 0.000819872247169388 NA NA NA hsa-miR-15a-5p MRAS 0.812445324157528 4.50263417099822e-20 -2.33160876190743 5.5050134478505e-74 miRNATAP -0.294536375038997 3.00707532146686e-08 NA NA NA hsa-miR-182-5p MRAS 2.36408084103818 2.60011457600281e-72 -2.33160876190743 5.5050134478505e-74 miRNATAP -0.524902959445825 1.41898946761564e-64 NA NA NA hsa-miR-29b-3p MRAS 0.438847962603729 6.46722433236121e-05 -2.33160876190743 5.5050134478505e-74 mirMAP -0.174910948134691 6.4488306106908e-05 NA NA NA hsa-miR-29c-3p MRAS -0.0652732378039769 0.563774115756922 -2.33160876190743 5.5050134478505e-74 mirMAP -0.272543828832133 1.27963297041164e-10 NA NA NA hsa-miR-3065-3p MRAS 1.62787885002468 6.81477830005026e-19 -2.33160876190743 5.5050134478505e-74 miRNATAP -0.192864005915779 2.71114562092703e-14 NA NA NA hsa-miR-30d-3p MRAS 0.264544633563642 0.00755023189129747 -2.33160876190743 5.5050134478505e-74 mirMAP -0.181655430735092 0.000198117921927286 NA NA NA hsa-miR-342-3p MRAS 1.21944481975657 6.81914373001202e-19 -2.33160876190743 5.5050134478505e-74 mirMAP -0.416322453382336 1.00207978880137e-36 NA NA NA hsa-miR-429 MRAS 2.84108892259147 3.88520896426515e-64 -2.33160876190743 5.5050134478505e-74 miRanda;miRNATAP -0.296364992468048 8.90534224451228e-31 NA NA NA hsa-miR-7-1-3p MRAS 0.686579567507582 1.20731554448806e-07 -2.33160876190743 5.5050134478505e-74 mirMAP -0.200268196549368 4.94694923734357e-08 NA NA NA hsa-miR-96-5p MRAS 3.24596558166606 1.92296159041707e-98 -2.33160876190743 5.5050134478505e-74 TargetScan;miRNATAP -0.416938612016912 1.97469399011339e-58 NA NA NA hsa-miR-21-5p MYC 2.32007501846389 3.08394781855554e-137 -1.13124656428776 3.22608205108151e-16 miRNAWalker2_validate -0.270190862069706 5.76701615920235e-10 22072622 In contrast the levels of β-catenin TCF/LEF activity and the expression of c-Myc Cyclin-D which are increased in CSCs are also augmented in miR-21 overexpressing colon cancer cells accompanied by an increased sphere forming ability in vitro and tumor formation in SCID mice colon cancer hsa-miR-34a-5p MYC 0.129201805242403 0.133261654068224 -1.13124656428776 3.22608205108151e-16 miRNAWalker2_validate;miRTarBase -0.216308870548993 0.000129276161670072 25572695;25686834;21460242;22159222;23640973;22830357;22235332 The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;miR 34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c Myc pathway;Myc mediated repression of microRNA 34a promotes high grade transformation of B cell lymphoma by dysregulation of FoxP1;MicroRNA 34a suppresses malignant transformation by targeting c Myc transcriptional complexes in human renal cell carcinoma; We investigated the functional effects of microRNA-34a miR-34a on c-Myc transcriptional complexes in renal cell carcinoma; miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region which was revealed by luciferase reporter assays; Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription indicating a novel role of miR-34a in the regulation of transcription by c-Myc;Among them miR-34a was also associated with poor prognosis in 2 independent series of leukemic and nodal MCL and in cooperation with high expression of the MYC oncogene;We report that miR-34a did not inhibit cell proliferation notwithstanding a marked down-regulation of c-MYC;MicroRNA 34a modulates c Myc transcriptional complexes to suppress malignancy in human prostate cancer cells; We studied the functional effects of miR-34a on c-Myc transcriptional complexes in PC-3 prostate cancer cells; miR-34a downregulated expression of c-Myc oncogene by targeting its 3' UTR as shown by luciferase reporter assays; This is the first report to document that miR-34a suppresses assembly and function of the c-Myc-Skp2-Miz1 complex that activates RhoA and the c-Myc-pTEFB complex that elongates transcription of various genes suggesting a novel role of miR-34a in the regulation of transcription by c-Myc complex ;;;malignant trasformation;worse prognosis;; bladder cancer;liver cancer;B cell lymphoma;kidney renal cell cancer;lymphoma;lymphoma;prostate cancer hsa-miR-429 MYC 2.84108892259147 3.88520896426515e-64 -1.13124656428776 3.22608205108151e-16 miRNAWalker2_validate -0.108453248703558 4.76591679996824e-05 21684154;24633485 miR 429 modulates the expression of c myc in human gastric carcinoma cells; SGC-7901 gastric cancer cells were transfected with miR-429 mimics and endogenous c-myc expression was detected by western blots; We performed functional assays using the 3'UTR of the c-myc gene as a miR-429 target in a luciferase reporter assay system; miR-429 significantly downregulated endogenous c-myc expression in SGC-7901 cells; Action of miR/429 on c-myc 3'UTR was confirmed; c-myc is an important miR-429 target gene;It is known that miR-429 is down-regulated and functions as a tumor suppressor by targeting c-myc and PLGG1 in gastric and breast cancer ; gastric cancer;sarcoma hsa-miR-103a-3p NF1 0.610673390034345 1.63113920514646e-12 -0.394546709839459 1.88157518863882e-05 MirTarget -0.298258204057073 7.68296810837731e-17 NA NA NA hsa-miR-107 NF1 0.678998026350662 2.56224148930538e-16 -0.394546709839459 1.88157518863882e-05 MirTarget;PITA;miRanda;miRNATAP -0.213773039066899 1.27282989374285e-08 NA NA NA hsa-miR-128-3p NF1 0.90296715955238 9.925204823863e-23 -0.394546709839459 1.88157518863882e-05 MirTarget -0.202019431505486 1.54710819140338e-09 NA NA NA hsa-miR-146b-5p NF1 0.631041661167954 6.20366593452965e-08 -0.394546709839459 1.88157518863882e-05 miRanda -0.199151597034007 8.6341967962311e-14 NA NA NA hsa-miR-148a-5p NF1 0.572692271754695 2.14306251522796e-06 -0.394546709839459 1.88157518863882e-05 MirTarget -0.175869814732318 1.05874103404454e-11 NA NA NA hsa-miR-15a-5p NF1 0.812445324157528 4.50263417099822e-20 -0.394546709839459 1.88157518863882e-05 MirTarget -0.308769926485221 3.26409823531366e-19 NA NA NA hsa-miR-16-1-3p NF1 1.30142784811196 2.53343713753744e-29 -0.394546709839459 1.88157518863882e-05 MirTarget -0.106075229157645 0.000154108549001089 NA NA NA hsa-miR-27a-3p NF1 0.388496361379095 1.42373532086331e-05 -0.394546709839459 1.88157518863882e-05 MirTarget -0.181895208507095 2.5659715334711e-07 NA NA NA hsa-miR-27b-3p NF1 -0.0796803270437447 0.410503155574393 -0.394546709839459 1.88157518863882e-05 MirTarget -0.109344267200185 0.000896087377699338 NA NA NA hsa-miR-340-5p NF1 1.0857159627596 4.94471062546756e-24 -0.394546709839459 1.88157518863882e-05 mirMAP -0.253924743873191 2.1923712592731e-19 NA NA NA hsa-miR-361-5p NF1 -0.0996867547900457 0.095428250126326 -0.394546709839459 1.88157518863882e-05 miRanda -0.427396849502152 8.30070228967362e-16 NA NA NA hsa-miR-362-5p NF1 -0.248676340901797 0.0726089851456282 -0.394546709839459 1.88157518863882e-05 mirMAP -0.163315496679587 5.33921764267452e-13 NA NA NA hsa-miR-455-5p NF1 0.284641224662773 0.0357572339594277 -0.394546709839459 1.88157518863882e-05 miRanda -0.202769455211226 1.03483221954599e-18 NA NA NA hsa-miR-182-5p NFATC2 2.36408084103818 2.60011457600281e-72 -1.56755219359383 1.9388283538799e-13 mirMAP -0.319993630027942 3.80744800734882e-10 NA NA NA hsa-miR-185-5p NFATC2 0.482334746589337 3.68475879959415e-09 -1.56755219359383 1.9388283538799e-13 MirTarget -0.480154397877674 9.64194904728437e-08 NA NA NA hsa-miR-19a-3p NFATC2 0.817507952171848 3.76285090469625e-08 -1.56755219359383 1.9388283538799e-13 mirMAP -0.325063324024532 3.38278468154619e-11 NA NA NA hsa-miR-19b-3p NFATC2 0.139124391010031 0.255658553872934 -1.56755219359383 1.9388283538799e-13 mirMAP -0.287342497987003 2.05092326956767e-06 NA NA NA hsa-miR-200b-5p NFATC2 1.43091697052145 2.07975242866479e-22 -1.56755219359383 1.9388283538799e-13 mirMAP -0.148120269747522 0.0033400668976821 NA NA NA hsa-miR-320b NFATC2 0.412787504747938 0.00113457276903985 -1.56755219359383 1.9388283538799e-13 MirTarget -0.160231542240436 0.00642139736942507 NA NA NA hsa-miR-340-5p NFATC2 1.0857159627596 4.94471062546756e-24 -1.56755219359383 1.9388283538799e-13 miRNATAP -0.377355443179726 1.70562760392822e-08 NA NA NA hsa-miR-3613-5p NFATC2 1.11067990676844 4.33424951743633e-21 -1.56755219359383 1.9388283538799e-13 mirMAP -0.344189531636949 1.85303094879685e-08 NA NA NA hsa-miR-423-5p NFATC2 -0.0644843381453004 0.462275547464843 -1.56755219359383 1.9388283538799e-13 PITA -0.329350686391576 0.000107038916546868 NA NA NA hsa-miR-590-3p NFATC2 1.27438512890514 1.03164723481469e-23 -1.56755219359383 1.9388283538799e-13 mirMAP -0.207787840865524 0.000469613853353843 NA NA NA hsa-miR-130b-5p NFATC4 1.0573161199584 2.55177349228739e-12 0.464846681575293 0.00077326896248743 mirMAP -0.273306003041798 2.37279973423709e-19 NA NA NA hsa-miR-150-5p NFATC4 -0.832049526091211 3.45299201139224e-05 0.464846681575293 0.00077326896248743 mirMAP -0.127353989190525 5.08033729715864e-08 NA NA NA hsa-miR-15b-3p NFATC4 1.12898579025388 1.18050912917317e-14 0.464846681575293 0.00077326896248743 mirMAP -0.238062507407611 4.12345167097552e-14 NA NA NA hsa-miR-181a-2-3p NFATC4 -0.0718643470098321 0.422077954889554 0.464846681575293 0.00077326896248743 mirMAP -0.265900817473076 5.67846111588394e-07 NA NA NA hsa-miR-185-3p NFATC4 0.86591374114446 7.8790769678542e-10 0.464846681575293 0.00077326896248743 MirTarget -0.221463917308086 4.38182247561287e-11 NA NA NA hsa-miR-2355-5p NFATC4 -0.221733044425126 0.0231054202524677 0.464846681575293 0.00077326896248743 MirTarget -0.314673921460914 7.76236682155888e-11 NA NA NA hsa-miR-29a-3p NFATC4 -0.699539666833076 1.13935003139957e-13 0.464846681575293 0.00077326896248743 miRNATAP -0.159424686343472 0.00138862402245239 NA NA NA hsa-miR-29b-3p NFATC4 0.438847962603729 6.46722433236121e-05 0.464846681575293 0.00077326896248743 miRNATAP -0.122774285938033 0.00449585095871782 NA NA NA hsa-miR-3607-3p NFATC4 0.00697875745616461 0.972073275173643 0.464846681575293 0.00077326896248743 miRNATAP -0.103148919948283 1.40847070939603e-05 NA NA NA hsa-miR-361-3p NFATC4 -0.0370446538644886 0.624902392829872 0.464846681575293 0.00077326896248743 mirMAP -0.221299437804629 0.000469274259610322 NA NA NA hsa-miR-484 NFATC4 0.349444060004737 0.00154491249625173 0.464846681575293 0.00077326896248743 MirTarget;miRNATAP -0.195541918029345 5.21748391548856e-06 NA NA NA hsa-miR-532-5p NFATC4 0.0386976222860582 0.682018574136515 0.464846681575293 0.00077326896248743 mirMAP -0.351153097111496 2.13922805026231e-12 NA NA NA hsa-miR-629-3p NFATC4 1.25035919247365 3.91361135469024e-14 0.464846681575293 0.00077326896248743 mirMAP -0.222553384296637 1.10177313904365e-14 NA NA NA hsa-miR-193b-3p NFKB2 -0.0550374855074773 0.65382485898551 0.702078446168725 2.89928548024604e-17 miRNAWalker2_validate -0.127046916566181 7.04088494909192e-08 NA NA NA hsa-miR-491-5p NFKB2 -1.04307210952796 1.14586501470398e-15 0.702078446168725 2.89928548024604e-17 miRanda -0.166200727380588 2.18421847197831e-14 NA NA NA hsa-let-7d-5p NGF 0.410958462607207 6.07808182756787e-06 -0.787725123054401 9.35669050853888e-08 MirTarget -0.171326999284145 0.00225973911147285 NA NA NA hsa-miR-429 NGF 2.84108892259147 3.88520896426515e-64 -0.787725123054401 9.35669050853888e-08 miRanda -0.12206490353919 1.36541405382157e-05 NA NA NA hsa-let-7i-5p NLK -0.333419326258177 3.56960810786801e-08 0.568183653225175 4.68554951142873e-14 miRNATAP -0.413862391863088 2.49706725878225e-22 NA NA NA hsa-miR-132-3p NLK -0.0365213889238607 0.668598301088667 0.568183653225175 4.68554951142873e-14 miRNATAP -0.147434106687348 1.72134800695252e-06 NA NA NA hsa-miR-139-5p NLK -3.25846663863766 2.62018989415003e-112 0.568183653225175 4.68554951142873e-14 miRanda -0.103239444031536 3.35421799377228e-11 NA NA NA hsa-miR-140-5p NLK -0.755971041589807 9.68060922934542e-14 0.568183653225175 4.68554951142873e-14 MirTarget;PITA;miRanda;miRNATAP -0.139208185186153 3.98951586060413e-08 NA NA NA hsa-miR-146b-5p NLK 0.631041661167954 6.20366593452965e-08 0.568183653225175 4.68554951142873e-14 miRanda -0.130772865651309 3.748420957412e-09 NA NA NA hsa-miR-152-3p NLK -0.26603867075042 0.0063861560676033 0.568183653225175 4.68554951142873e-14 MirTarget -0.121964596915363 5.58054397729548e-06 NA NA NA hsa-miR-195-3p NLK -1.49582726452416 6.53261924105147e-40 0.568183653225175 4.68554951142873e-14 mirMAP -0.145388282098103 3.0064135076299e-11 NA NA NA hsa-miR-199b-5p NLK -1.37022396448377 3.25758057539223e-26 0.568183653225175 4.68554951142873e-14 MirTarget;PITA;miRanda;miRNATAP -0.130208304038465 2.10468258720444e-11 NA NA NA hsa-miR-217 NLK -0.616728851115349 8.64977119332241e-05 0.568183653225175 4.68554951142873e-14 miRanda -0.107421092941157 6.83560697467638e-11 NA NA NA hsa-miR-221-3p NLK -0.317970198201501 0.00910855267413448 0.568183653225175 4.68554951142873e-14 MirTarget;miRNATAP -0.160004395790496 4.50992101797211e-14 NA NA NA hsa-miR-24-3p NLK -0.120123317289941 0.21432376743243 0.568183653225175 4.68554951142873e-14 miRNATAP -0.110962647460226 4.40407432880344e-05 NA NA NA hsa-miR-25-3p NLK -0.00546790775985073 0.944061771389468 0.568183653225175 4.68554951142873e-14 MirTarget;miRNATAP -0.106492227212925 0.0017026454555609 NA NA NA hsa-miR-26a-5p NLK -0.481180084102235 1.82368246174758e-10 0.568183653225175 4.68554951142873e-14 miRNATAP -0.184587948058077 8.44159773363628e-08 NA NA NA hsa-miR-27a-3p NLK 0.388496361379095 1.42373532086331e-05 0.568183653225175 4.68554951142873e-14 miRNATAP -0.108956811004123 0.000196776667929282 NA NA NA hsa-miR-27b-3p NLK -0.0796803270437447 0.410503155574393 0.568183653225175 4.68554951142873e-14 miRNATAP -0.115578430021538 2.04956118003642e-05 NA NA NA hsa-miR-28-5p NLK -0.14267073663385 0.0497619246260571 0.568183653225175 4.68554951142873e-14 miRanda -0.182841180159811 4.4803820168759e-07 NA NA NA hsa-miR-381-3p NLK -1.28028930293369 1.61402949866141e-23 0.568183653225175 4.68554951142873e-14 MirTarget -0.176789380063327 1.23463667918594e-19 NA NA NA hsa-miR-455-5p NLK 0.284641224662773 0.0357572339594277 0.568183653225175 4.68554951142873e-14 MirTarget;PITA;miRanda;miRNATAP -0.123543532954721 1.15133287100025e-10 NA NA NA hsa-miR-485-3p NLK -0.866822427729628 4.5194665263492e-11 0.568183653225175 4.68554951142873e-14 MirTarget;PITA;miRNATAP -0.115025747481124 5.816614344041e-09 NA NA NA hsa-miR-92a-3p NLK -0.342420481092807 0.000732275969501111 0.568183653225175 4.68554951142873e-14 MirTarget;miRNATAP -0.108248489207265 2.75005198560074e-05 NA NA NA hsa-let-7d-5p NR4A1 0.410958462607207 6.07808182756787e-06 -1.94844386566107 4.44471295400257e-27 miRNAWalker2_validate -0.392348094917098 2.16168423920223e-08 NA NA NA hsa-miR-324-5p NR4A1 0.211552647440779 0.139408130311654 -1.94844386566107 4.44471295400257e-27 miRanda -0.316675057081773 8.15079425391408e-13 NA NA NA hsa-miR-93-5p NR4A1 1.01788600209314 1.24312921618126e-21 -1.94844386566107 4.44471295400257e-27 miRNAWalker2_validate -0.261546738240957 8.05513957986116e-06 NA NA NA hsa-miR-26a-5p NRAS -0.481180084102235 1.82368246174758e-10 0.183758021967058 0.0269071454303856 mirMAP;miRNATAP -0.171830491303475 4.57786379954293e-06 26458859 MiR 26a enhances the sensitivity of gastric cancer cells to cisplatin by targeting NRAS and E2F2; Our results suggest that miR-26a can improve the sensitivity of GC cells to cisplatin-based chemotherapies through targeting NRAS and E2F2 and provide the first evidence of the potential utility of miR-26a as a sensitizer in chemotherapy for GC gastric cancer hsa-miR-29a-3p NRAS -0.699539666833076 1.13935003139957e-13 0.183758021967058 0.0269071454303856 miRNATAP -0.131093968344875 1.07589675767432e-05 NA NA NA hsa-miR-29c-3p NRAS -0.0652732378039769 0.563774115756922 0.183758021967058 0.0269071454303856 miRNATAP -0.211489064949879 1.38049039033829e-17 NA NA NA hsa-miR-381-3p NRAS -1.28028930293369 1.61402949866141e-23 0.183758021967058 0.0269071454303856 mirMAP -0.110038347690747 3.16999123322707e-07 NA NA NA hsa-miR-142-3p NTF3 1.53951237846104 2.06769936282034e-17 -2.35193065681614 1.75397805257351e-24 miRanda -0.25559087299935 4.55546500058392e-09 NA NA NA hsa-miR-200b-3p NTF3 2.11744072703209 1.66710572104191e-43 -2.35193065681614 1.75397805257351e-24 TargetScan -0.321874947951398 1.05323715646676e-10 NA NA NA hsa-miR-200c-3p NTF3 2.07038651806183 6.84613386286599e-51 -2.35193065681614 1.75397805257351e-24 miRNAWalker2_validate;miRNATAP -0.405535845133949 1.08735324650309e-13 NA NA NA hsa-miR-21-5p NTF3 2.32007501846389 3.08394781855554e-137 -2.35193065681614 1.75397805257351e-24 miRTarBase;miRNATAP -0.481266108265449 4.86045305948914e-11 NA NA NA hsa-miR-429 NTF3 2.84108892259147 3.88520896426515e-64 -2.35193065681614 1.75397805257351e-24 PITA;miRanda;miRNATAP -0.318352061640753 7.25173081695566e-13 NA NA NA hsa-miR-590-3p NTF3 1.27438512890514 1.03164723481469e-23 -2.35193065681614 1.75397805257351e-24 miRanda -0.327104104078733 4.60676593188325e-07 NA NA NA hsa-miR-590-5p NTF3 0.746515607868274 8.51300479640125e-09 -2.35193065681614 1.75397805257351e-24 PITA;miRanda;miRNATAP -0.249639896667382 5.92923109438771e-05 NA NA NA hsa-miR-107 NTRK2 0.678998026350662 2.56224148930538e-16 -4.03565225718056 9.2986992242195e-64 PITA;miRanda -0.836390405916991 1.12926053720617e-15 NA NA NA hsa-miR-130b-3p NTRK2 1.38122163823846 1.00932179737836e-26 -4.03565225718056 9.2986992242195e-64 mirMAP -0.769347321078169 1.17967706482035e-32 NA NA NA hsa-miR-130b-5p NTRK2 1.0573161199584 2.55177349228739e-12 -4.03565225718056 9.2986992242195e-64 mirMAP -0.488025092950443 1.17958520925326e-17 NA NA NA hsa-miR-142-3p NTRK2 1.53951237846104 2.06769936282034e-17 -4.03565225718056 9.2986992242195e-64 miRanda -0.311735989864694 5.64944316358857e-11 NA NA NA hsa-miR-142-5p NTRK2 1.16509303143593 1.96641162209073e-13 -4.03565225718056 9.2986992242195e-64 mirMAP -0.267780450784351 1.15450126012637e-06 NA NA NA hsa-miR-146b-5p NTRK2 0.631041661167954 6.20366593452965e-08 -4.03565225718056 9.2986992242195e-64 PITA;miRanda -0.314474616023657 3.27685992622639e-05 NA NA NA hsa-miR-148a-5p NTRK2 0.572692271754695 2.14306251522796e-06 -4.03565225718056 9.2986992242195e-64 mirMAP -0.198050799697867 0.00696218497554125 NA NA NA hsa-miR-151a-5p NTRK2 0.509210376738198 3.17540030607215e-07 -4.03565225718056 9.2986992242195e-64 miRNATAP -0.780564562612712 3.70349058685946e-19 NA NA NA hsa-miR-155-5p NTRK2 1.09766314984151 4.55650930885814e-15 -4.03565225718056 9.2986992242195e-64 mirMAP -0.41539155563853 1.85377330452013e-11 NA NA NA hsa-miR-15b-3p NTRK2 1.12898579025388 1.18050912917317e-14 -4.03565225718056 9.2986992242195e-64 mirMAP -0.562890529553338 5.4599239852998e-22 NA NA NA hsa-miR-17-3p NTRK2 0.721439431208839 7.95900548819742e-10 -4.03565225718056 9.2986992242195e-64 miRNATAP -0.45111098908225 1.45919732139291e-09 NA NA NA hsa-miR-181a-5p NTRK2 0.635863607630183 6.72486918157744e-11 -4.03565225718056 9.2986992242195e-64 mirMAP -0.680395100851069 2.6766742709822e-14 NA NA NA hsa-miR-181b-5p NTRK2 1.22749257795094 1.21998198830919e-27 -4.03565225718056 9.2986992242195e-64 mirMAP -0.779842929679368 9.18504195603619e-26 NA NA NA hsa-miR-182-5p NTRK2 2.36408084103818 2.60011457600281e-72 -4.03565225718056 9.2986992242195e-64 mirMAP -0.570548474380832 3.49801193738836e-21 NA NA NA hsa-miR-185-5p NTRK2 0.482334746589337 3.68475879959415e-09 -4.03565225718056 9.2986992242195e-64 mirMAP -0.870491482821692 3.554861973461e-16 NA NA NA hsa-miR-200c-3p NTRK2 2.07038651806183 6.84613386286599e-51 -4.03565225718056 9.2986992242195e-64 miRNAWalker2_validate;miRTarBase -0.540459062838814 7.12630091174492e-20 23209748;23074172 miR 200c sensitizes breast cancer cells to doxorubicin treatment by decreasing TrkB and Bmi1 expression;miR-200c also targets TrkB a mediator of resistance to anoikis ;drug resistance breast cancer;ovarian cancer hsa-miR-21-5p NTRK2 2.32007501846389 3.08394781855554e-137 -4.03565225718056 9.2986992242195e-64 mirMAP -1.20592530757402 1.06429280476928e-57 NA NA NA hsa-miR-27b-5p NTRK2 0.478244809913032 2.28657237923291e-06 -4.03565225718056 9.2986992242195e-64 mirMAP -0.459936572788305 1.37095676083519e-07 NA NA NA hsa-miR-301a-3p NTRK2 1.32170168375632 2.12280368957514e-15 -4.03565225718056 9.2986992242195e-64 mirMAP -0.591414503280674 3.56317078452758e-31 NA NA NA hsa-miR-32-5p NTRK2 1.38676603945192 2.29428299685976e-34 -4.03565225718056 9.2986992242195e-64 mirMAP -0.661395204008918 3.13696590151528e-19 NA NA NA hsa-miR-330-5p NTRK2 0.626063225953928 3.42215028606779e-09 -4.03565225718056 9.2986992242195e-64 miRanda -0.478715290991117 7.66297627939398e-09 NA NA NA hsa-miR-33a-5p NTRK2 1.35185127289399 9.80509199125785e-12 -4.03565225718056 9.2986992242195e-64 mirMAP -0.330110530234138 1.17990045018443e-13 NA NA NA hsa-miR-340-5p NTRK2 1.0857159627596 4.94471062546756e-24 -4.03565225718056 9.2986992242195e-64 mirMAP -0.658186289275308 1.12023703246196e-16 NA NA NA hsa-miR-342-3p NTRK2 1.21944481975657 6.81914373001202e-19 -4.03565225718056 9.2986992242195e-64 miRanda -0.259575565229622 4.07249780461087e-05 NA NA NA hsa-miR-362-5p NTRK2 -0.248676340901797 0.0726089851456282 -4.03565225718056 9.2986992242195e-64 mirMAP -0.211021259711251 0.00102124609335382 NA NA NA hsa-miR-429 NTRK2 2.84108892259147 3.88520896426515e-64 -4.03565225718056 9.2986992242195e-64 PITA;miRanda;miRNATAP -0.51698534306774 1.82175500468262e-27 NA NA NA hsa-miR-454-3p NTRK2 1.28177672191095 6.84024979484587e-21 -4.03565225718056 9.2986992242195e-64 mirMAP -0.612915092365335 8.08891527812014e-23 NA NA NA hsa-miR-455-3p NTRK2 0.678392920628872 0.000327758844555877 -4.03565225718056 9.2986992242195e-64 mirMAP -0.199163639140476 2.0930591380016e-05 NA NA NA hsa-miR-532-5p NTRK2 0.0386976222860582 0.682018574136515 -4.03565225718056 9.2986992242195e-64 PITA -0.521210748289278 3.09260110111958e-08 NA NA NA hsa-miR-576-5p NTRK2 0.0649387707567879 0.588791966096287 -4.03565225718056 9.2986992242195e-64 PITA;mirMAP -0.278348766635835 0.000174544446483956 NA NA NA hsa-miR-590-3p NTRK2 1.27438512890514 1.03164723481469e-23 -4.03565225718056 9.2986992242195e-64 PITA;miRanda;mirMAP -0.630708695964853 1.65227664250245e-19 NA NA NA hsa-miR-590-5p NTRK2 0.746515607868274 8.51300479640125e-09 -4.03565225718056 9.2986992242195e-64 miRanda;mirMAP -0.533409974311982 1.82799161345103e-15 NA NA NA hsa-let-7i-5p PAK1 -0.333419326258177 3.56960810786801e-08 0.689577121383134 3.29086569405593e-11 miRNATAP -0.205590450324816 0.000613477641577343 NA NA NA hsa-miR-199a-3p PAK1 -0.174830922802531 0.138748242352612 0.689577121383134 3.29086569405593e-11 PITA -0.112484835583981 0.000232116385033466 NA NA NA hsa-miR-199a-5p PAK1 -0.314703593105081 0.00909304983051124 0.689577121383134 3.29086569405593e-11 miRanda -0.141163072158186 2.14274398700042e-06 NA NA NA hsa-miR-199b-3p PAK1 -0.173412359075504 0.143232985227463 0.689577121383134 3.29086569405593e-11 PITA -0.111647781149534 0.000247102113603849 NA NA NA hsa-miR-199b-5p PAK1 -1.37022396448377 3.25758057539223e-26 0.689577121383134 3.29086569405593e-11 miRanda -0.172814671194024 1.07117680121655e-10 NA NA NA hsa-miR-140-3p PAK2 -1.25844395244141 5.29222651039892e-33 0.161029955747728 0.0079135487503 MirTarget;PITA;miRNATAP -0.178278329352708 7.31154043475859e-22 NA NA NA hsa-miR-26a-5p PAK2 -0.481180084102235 1.82368246174758e-10 0.161029955747728 0.0079135487503 MirTarget;miRNATAP -0.187919188954162 4.38967274156601e-12 NA NA NA hsa-miR-361-5p PAK2 -0.0996867547900457 0.095428250126326 0.161029955747728 0.0079135487503 mirMAP -0.202229020706329 8.03135763719411e-09 NA NA NA hsa-let-7d-5p PDGFA 0.410958462607207 6.07808182756787e-06 -1.03194821362155 2.98319775634862e-27 miRNAWalker2_validate -0.111085037882515 0.0028367772618075 NA NA NA hsa-miR-331-5p PDGFA 0.682437632502949 4.10871642662371e-11 -1.03194821362155 2.98319775634862e-27 PITA;miRNATAP -0.22667510028007 1.7281960179029e-12 NA NA NA hsa-miR-484 PDGFA 0.349444060004737 0.00154491249625173 -1.03194821362155 2.98319775634862e-27 PITA;miRNATAP -0.214059857890823 1.54568697231701e-12 NA NA NA hsa-miR-590-3p PDGFA 1.27438512890514 1.03164723481469e-23 -1.03194821362155 2.98319775634862e-27 miRanda -0.165100330465473 7.8988455074446e-10 NA NA NA hsa-miR-590-5p PDGFA 0.746515607868274 8.51300479640125e-09 -1.03194821362155 2.98319775634862e-27 miRanda -0.119998279179232 3.27111011320567e-06 NA NA NA hsa-let-7d-5p PDGFB 0.410958462607207 6.07808182756787e-06 0.0445377066563912 0.601024636333503 miRNATAP -0.127460924180761 6.8859001946812e-05 NA NA NA hsa-let-7g-5p PDGFB 0.0200025784917734 0.791635298815256 0.0445377066563912 0.601024636333503 miRNATAP -0.148185313332358 0.000134872450400757 NA NA NA hsa-let-7i-5p PDGFB -0.333419326258177 3.56960810786801e-08 0.0445377066563912 0.601024636333503 miRNATAP -0.131426457663067 0.00682130071674743 NA NA NA hsa-miR-146b-3p PDGFB -0.260891807886908 0.0211838235241739 0.0445377066563912 0.601024636333503 miRNAWalker2_validate -0.113394049081063 1.0320398497476e-05 NA NA NA hsa-miR-17-5p PDGFB 0.599531757298529 1.07318660415906e-05 0.0445377066563912 0.601024636333503 TargetScan -0.107407253083859 4.08751757932673e-07 NA NA NA hsa-miR-29a-3p PDGFB -0.699539666833076 1.13935003139957e-13 0.0445377066563912 0.601024636333503 MirTarget;miRNATAP -0.128475198337676 2.5654295496112e-05 NA NA NA hsa-let-7a-3p PDGFRA 0.466622567891891 3.70886257943079e-07 -1.84169721584144 2.50038285124215e-31 mirMAP -0.329460092115081 6.44888590147222e-08 NA NA NA hsa-miR-106a-5p PDGFRA 0.574594373206545 0.000145868284001732 -1.84169721584144 2.50038285124215e-31 MirTarget;miRNATAP -0.114055302211927 0.0021406545639755 NA NA NA hsa-miR-106b-5p PDGFRA 1.22477789913175 2.31787213143326e-32 -1.84169721584144 2.50038285124215e-31 MirTarget;miRNATAP -0.488023399387153 1.85919087848084e-21 NA NA NA hsa-miR-130b-3p PDGFRA 1.38122163823846 1.00932179737836e-26 -1.84169721584144 2.50038285124215e-31 MirTarget;miRNATAP -0.205861486268687 1.18866735754345e-06 NA NA NA hsa-miR-141-3p PDGFRA 2.99777540204168 1.26370498493024e-78 -1.84169721584144 2.50038285124215e-31 MirTarget -0.465703815469129 7.78017639246501e-55 NA NA NA hsa-miR-149-5p PDGFRA 0.218233101703391 0.261629158371175 -1.84169721584144 2.50038285124215e-31 MirTarget;miRNATAP -0.10186586746034 0.000432641759044271 NA NA NA hsa-miR-16-1-3p PDGFRA 1.30142784811196 2.53343713753744e-29 -1.84169721584144 2.50038285124215e-31 MirTarget -0.445034147047717 7.48526207581866e-20 NA NA NA hsa-miR-17-5p PDGFRA 0.599531757298529 1.07318660415906e-05 -1.84169721584144 2.50038285124215e-31 MirTarget;TargetScan;miRNATAP -0.230385311598016 1.83020228188668e-08 NA NA NA hsa-miR-181b-5p PDGFRA 1.22749257795094 1.21998198830919e-27 -1.84169721584144 2.50038285124215e-31 MirTarget;miRNATAP -0.19733318786805 4.51362347726677e-05 NA NA NA hsa-miR-181c-5p PDGFRA 0.574847839298605 4.51287502066478e-07 -1.84169721584144 2.50038285124215e-31 MirTarget;miRNATAP -0.199505884862497 4.93594812999378e-05 NA NA NA hsa-miR-181d-5p PDGFRA 0.782618466877349 1.2821116358212e-09 -1.84169721584144 2.50038285124215e-31 MirTarget -0.209000657310327 1.2726595161397e-06 NA NA NA hsa-miR-182-5p PDGFRA 2.36408084103818 2.60011457600281e-72 -1.84169721584144 2.50038285124215e-31 miRNATAP -0.488133036134936 5.32981617385656e-39 NA NA NA hsa-miR-193a-3p PDGFRA 0.310617999804917 0.00477640270974957 -1.84169721584144 2.50038285124215e-31 miRanda -0.236933469215575 3.5076412689528e-06 NA NA NA hsa-miR-200a-3p PDGFRA 2.55218480823434 2.96135446816238e-51 -1.84169721584144 2.50038285124215e-31 MirTarget -0.404359885272289 5.76229938736958e-42 NA NA NA hsa-miR-20a-5p PDGFRA 0.44979911120222 0.000602386964327228 -1.84169721584144 2.50038285124215e-31 MirTarget;miRNATAP -0.252447130222501 3.08338747587722e-09 NA NA NA hsa-miR-20b-5p PDGFRA 0.78236583455125 8.7938334801223e-05 -1.84169721584144 2.50038285124215e-31 MirTarget;miRNATAP -0.120554127383801 1.73060256254725e-05 NA NA NA hsa-miR-29b-2-5p PDGFRA -0.263499971180298 0.0400001755611965 -1.84169721584144 2.50038285124215e-31 mirMAP -0.308292211262466 1.26968663702118e-12 NA NA NA hsa-miR-29b-3p PDGFRA 0.438847962603729 6.46722433236121e-05 -1.84169721584144 2.50038285124215e-31 MirTarget -0.500389516534886 1.15065170563473e-23 NA NA NA hsa-miR-29c-3p PDGFRA -0.0652732378039769 0.563774115756922 -1.84169721584144 2.50038285124215e-31 MirTarget -0.350109088283135 1.37340184176404e-12 NA NA NA hsa-miR-301a-3p PDGFRA 1.32170168375632 2.12280368957514e-15 -1.84169721584144 2.50038285124215e-31 MirTarget;miRNATAP -0.255990348992222 8.11143570915912e-15 NA NA NA hsa-miR-320b PDGFRA 0.412787504747938 0.00113457276903985 -1.84169721584144 2.50038285124215e-31 miRanda -0.183733564050286 3.69207458785768e-05 NA NA NA hsa-miR-330-5p PDGFRA 0.626063225953928 3.42215028606779e-09 -1.84169721584144 2.50038285124215e-31 miRanda -0.192776801359275 0.000261739400977773 NA NA NA hsa-miR-338-3p PDGFRA 0.0799903526884966 0.575137668326679 -1.84169721584144 2.50038285124215e-31 miRanda -0.319924077772208 1.84779948590881e-16 NA NA NA hsa-miR-339-5p PDGFRA -0.211548290465418 0.0685885445822389 -1.84169721584144 2.50038285124215e-31 miRanda -0.18956471906179 9.38243938310758e-05 NA NA NA hsa-miR-33a-5p PDGFRA 1.35185127289399 9.80509199125785e-12 -1.84169721584144 2.50038285124215e-31 MirTarget;miRNATAP -0.153487879078261 6.47868493614725e-08 NA NA NA hsa-miR-342-3p PDGFRA 1.21944481975657 6.81914373001202e-19 -1.84169721584144 2.50038285124215e-31 MirTarget;miRanda;miRNATAP -0.370862046281642 3.2391388940783e-21 NA NA NA hsa-miR-34a-5p PDGFRA 0.129201805242403 0.133261654068224 -1.84169721584144 2.50038285124215e-31 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.257308196495663 9.23678964579895e-05 22750848 Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network glioblastoma hsa-miR-429 PDGFRA 2.84108892259147 3.88520896426515e-64 -1.84169721584144 2.50038285124215e-31 miRanda;miRNATAP -0.373691764862624 4.97896969778458e-36 NA NA NA hsa-miR-454-3p PDGFRA 1.28177672191095 6.84024979484587e-21 -1.84169721584144 2.50038285124215e-31 MirTarget;miRNATAP -0.35092972448673 9.46773059007511e-19 NA NA NA hsa-miR-590-3p PDGFRA 1.27438512890514 1.03164723481469e-23 -1.84169721584144 2.50038285124215e-31 miRanda;mirMAP -0.264364229545702 3.69842178603011e-09 NA NA NA hsa-miR-590-5p PDGFRA 0.746515607868274 8.51300479640125e-09 -1.84169721584144 2.50038285124215e-31 miRanda -0.212109048295796 7.97276608700393e-07 NA NA NA hsa-miR-664a-3p PDGFRA -0.237699857923843 0.0197071390183375 -1.84169721584144 2.50038285124215e-31 mirMAP -0.180157525965088 0.00115407518602231 NA NA NA hsa-miR-7-1-3p PDGFRA 0.686579567507582 1.20731554448806e-07 -1.84169721584144 2.50038285124215e-31 mirMAP -0.307956291240907 5.06202621843896e-13 NA NA NA hsa-miR-93-5p PDGFRA 1.01788600209314 1.24312921618126e-21 -1.84169721584144 2.50038285124215e-31 MirTarget;miRNATAP -0.499449521835939 3.61616920956413e-23 NA NA NA hsa-miR-96-5p PDGFRA 3.24596558166606 1.92296159041707e-98 -1.84169721584144 2.50038285124215e-31 TargetScan;miRNATAP -0.477431215706839 8.10828261241382e-56 NA NA NA hsa-miR-29a-3p PDGFRB -0.699539666833076 1.13935003139957e-13 -0.363053423609744 0.000930448280520273 miRNATAP -0.173489965488495 1.08203138499797e-05 NA NA NA hsa-miR-29b-3p PDGFRB 0.438847962603729 6.46722433236121e-05 -0.363053423609744 0.000930448280520273 miRNATAP -0.37404884670886 1.21864334087282e-29 NA NA NA hsa-miR-29c-3p PDGFRB -0.0652732378039769 0.563774115756922 -0.363053423609744 0.000930448280520273 miRNATAP -0.131693600188518 7.8570505856864e-05 NA NA NA hsa-miR-3127-5p PDGFRB 0.903405128081314 1.1325923598273e-12 -0.363053423609744 0.000930448280520273 mirMAP -0.190856341471899 4.71469241759899e-11 NA NA NA hsa-miR-338-3p PDGFRB 0.0799903526884966 0.575137668326679 -0.363053423609744 0.000930448280520273 miRanda -0.135507787608143 2.53645768220537e-07 NA NA NA hsa-miR-342-3p PDGFRB 1.21944481975657 6.81914373001202e-19 -0.363053423609744 0.000930448280520273 miRanda -0.120554527834238 6.56852598546147e-06 NA NA NA hsa-miR-361-3p PDGFRB -0.0370446538644886 0.624902392829872 -0.363053423609744 0.000930448280520273 MirTarget -0.332024100699143 2.34711270011442e-11 NA NA NA hsa-miR-484 PDGFRB 0.349444060004737 0.00154491249625173 -0.363053423609744 0.000930448280520273 mirMAP -0.17421282482312 2.9286066688125e-07 NA NA NA hsa-miR-664a-3p PDGFRB -0.237699857923843 0.0197071390183375 -0.363053423609744 0.000930448280520273 MirTarget -0.173222382702463 2.70287047774181e-06 NA NA NA hsa-miR-335-5p PLA2G10 -2.61355235628987 2.6462884165886e-51 2.58043646182214 4.92737062096255e-20 miRNAWalker2_validate -0.240771211021386 6.4577488535009e-06 NA NA NA hsa-miR-106b-5p PLA2G12A 1.22477789913175 2.31787213143326e-32 -0.0767339324942657 0.320227624149064 mirMAP -0.183165390972991 4.54130357375406e-14 NA NA NA hsa-miR-140-5p PLA2G12A -0.755971041589807 9.68060922934542e-14 -0.0767339324942657 0.320227624149064 miRanda -0.111542024637763 1.35365987147148e-05 NA NA NA hsa-miR-142-5p PLA2G12A 1.16509303143593 1.96641162209073e-13 -0.0767339324942657 0.320227624149064 mirMAP -0.164913109247326 4.6875674436803e-25 NA NA NA hsa-miR-150-5p PLA2G12A -0.832049526091211 3.45299201139224e-05 -0.0767339324942657 0.320227624149064 mirMAP -0.111662148908207 3.06157352459707e-18 NA NA NA hsa-miR-17-3p PLA2G12A 0.721439431208839 7.95900548819742e-10 -0.0767339324942657 0.320227624149064 mirMAP -0.253144933851736 4.89224736100484e-32 NA NA NA hsa-miR-17-5p PLA2G12A 0.599531757298529 1.07318660415906e-05 -0.0767339324942657 0.320227624149064 mirMAP -0.127012977325803 3.04058434715778e-11 NA NA NA hsa-miR-181a-5p PLA2G12A 0.635863607630183 6.72486918157744e-11 -0.0767339324942657 0.320227624149064 mirMAP -0.134430081680054 5.19065518814422e-07 NA NA NA hsa-miR-181b-5p PLA2G12A 1.22749257795094 1.21998198830919e-27 -0.0767339324942657 0.320227624149064 mirMAP -0.120036146387448 1.07543463907263e-07 NA NA NA hsa-miR-181c-5p PLA2G12A 0.574847839298605 4.51287502066478e-07 -0.0767339324942657 0.320227624149064 mirMAP -0.100247651965663 1.33006792327325e-05 NA NA NA hsa-miR-20a-5p PLA2G12A 0.44979911120222 0.000602386964327228 -0.0767339324942657 0.320227624149064 mirMAP -0.175197436263123 6.04261955331153e-19 NA NA NA hsa-miR-340-5p PLA2G12A 1.0857159627596 4.94471062546756e-24 -0.0767339324942657 0.320227624149064 mirMAP -0.150943983546617 2.10910414124104e-10 NA NA NA hsa-miR-374a-3p PLA2G12A 0.34122393953022 2.28714105382856e-05 -0.0767339324942657 0.320227624149064 mirMAP -0.186349201857001 1.16022667976458e-08 NA NA NA hsa-miR-590-3p PLA2G12A 1.27438512890514 1.03164723481469e-23 -0.0767339324942657 0.320227624149064 PITA;miRanda;miRNATAP -0.102840132884099 1.06330234376856e-06 NA NA NA hsa-miR-93-5p PLA2G12A 1.01788600209314 1.24312921618126e-21 -0.0767339324942657 0.320227624149064 mirMAP -0.16549588295931 4.93444853641411e-12 NA NA NA hsa-miR-338-3p PLA2G2D 0.0799903526884966 0.575137668326679 0.903280745620558 0.00272639495429831 mirMAP -0.305823183035727 2.42881736158958e-05 NA NA NA hsa-miR-491-5p PLA2G2D -1.04307210952796 1.14586501470398e-15 0.903280745620558 0.00272639495429831 miRanda -0.303164177428281 0.000114708849288704 NA NA NA hsa-let-7d-5p PLA2G3 0.410958462607207 6.07808182756787e-06 -0.0228531479929619 0.949949867171402 MirTarget -0.390954081984527 0.00443149825913952 NA NA NA hsa-miR-98-5p PLA2G3 0.656336869298973 9.03113188590466e-15 -0.0228531479929619 0.949949867171402 MirTarget -0.648796955398098 8.08248391006914e-06 NA NA NA hsa-miR-1301-3p PLA2G4A 1.80754972811286 2.96809840886499e-36 -2.53505849018895 2.47040724186526e-47 MirTarget -0.203345804091857 1.5174493413245e-06 NA NA NA hsa-miR-181b-5p PLA2G4A 1.22749257795094 1.21998198830919e-27 -2.53505849018895 2.47040724186526e-47 MirTarget -0.153639845367177 0.00515313352093704 NA NA NA hsa-miR-181c-5p PLA2G4A 0.574847839298605 4.51287502066478e-07 -2.53505849018895 2.47040724186526e-47 MirTarget -0.154311584569564 0.00569702831812597 NA NA NA hsa-miR-128-3p PLA2G5 0.90296715955238 9.925204823863e-23 -1.74013770344495 1.68659762319176e-24 miRNAWalker2_validate -0.343165736360574 6.67242916325325e-08 NA NA NA hsa-miR-330-5p PLA2G5 0.626063225953928 3.42215028606779e-09 -1.74013770344495 1.68659762319176e-24 miRanda -0.327612442041135 4.95284334111594e-09 NA NA NA hsa-miR-429 PLA2G5 2.84108892259147 3.88520896426515e-64 -1.74013770344495 1.68659762319176e-24 miRanda -0.333900447814793 4.56777352167666e-25 NA NA NA hsa-miR-590-3p PLA2G5 1.27438512890514 1.03164723481469e-23 -1.74013770344495 1.68659762319176e-24 miRanda;miRNATAP -0.259835376156245 5.88331349780208e-08 NA NA NA hsa-miR-590-5p PLA2G5 0.746515607868274 8.51300479640125e-09 -1.74013770344495 1.68659762319176e-24 miRanda -0.191992596578893 2.94285112416766e-05 NA NA NA hsa-miR-106b-5p PPM1A 1.22477789913175 2.31787213143326e-32 -0.332441598633123 9.27107504543357e-08 mirMAP -0.203311791845623 1.18302995986783e-25 NA NA NA hsa-miR-107 PPM1A 0.678998026350662 2.56224148930538e-16 -0.332441598633123 9.27107504543357e-08 miRanda -0.165122102825924 7.04263138467542e-11 NA NA NA hsa-miR-140-3p PPM1A -1.25844395244141 5.29222651039892e-33 -0.332441598633123 9.27107504543357e-08 miRNATAP -0.162374115725534 3.86701779184273e-17 NA NA NA hsa-miR-142-5p PPM1A 1.16509303143593 1.96641162209073e-13 -0.332441598633123 9.27107504543357e-08 mirMAP -0.103745007461897 2.66951825256063e-15 NA NA NA hsa-miR-146b-3p PPM1A -0.260891807886908 0.0211838235241739 -0.332441598633123 9.27107504543357e-08 miRNATAP -0.191834471816729 2.40778834041484e-25 NA NA NA hsa-miR-146b-5p PPM1A 0.631041661167954 6.20366593452965e-08 -0.332441598633123 9.27107504543357e-08 miRanda;miRNATAP -0.233675115582338 4.49685149707849e-41 NA NA NA hsa-miR-148a-5p PPM1A 0.572692271754695 2.14306251522796e-06 -0.332441598633123 9.27107504543357e-08 mirMAP -0.141849431738637 3.38687141764239e-16 NA NA NA hsa-miR-15a-5p PPM1A 0.812445324157528 4.50263417099822e-20 -0.332441598633123 9.27107504543357e-08 MirTarget;miRNATAP -0.19235820062422 1.94612786843608e-16 NA NA NA hsa-miR-16-1-3p PPM1A 1.30142784811196 2.53343713753744e-29 -0.332441598633123 9.27107504543357e-08 mirMAP -0.107366199111624 1.22723236804135e-08 NA NA NA hsa-miR-17-5p PPM1A 0.599531757298529 1.07318660415906e-05 -0.332441598633123 9.27107504543357e-08 TargetScan;mirMAP -0.127628121217336 1.23502921313336e-16 NA NA NA hsa-miR-340-5p PPM1A 1.0857159627596 4.94471062546756e-24 -0.332441598633123 9.27107504543357e-08 mirMAP -0.164338293385432 7.92699873902545e-18 NA NA NA hsa-miR-361-5p PPM1A -0.0996867547900457 0.095428250126326 -0.332441598633123 9.27107504543357e-08 miRanda -0.28618125744874 1.59506719168705e-15 NA NA NA hsa-miR-369-3p PPM1A 0.0880848299432269 0.48519534195924 -0.332441598633123 9.27107504543357e-08 MirTarget -0.113721363285154 1.92591579245551e-11 NA NA NA hsa-miR-374a-5p PPM1A -0.239709888246804 0.00309819667153627 -0.332441598633123 9.27107504543357e-08 mirMAP -0.171702150929929 7.41450827246935e-11 NA NA NA hsa-miR-500a-5p PPM1A 0.209805801129289 0.119177819862398 -0.332441598633123 9.27107504543357e-08 mirMAP -0.135345133818973 1.48555309093397e-17 NA NA NA hsa-miR-532-5p PPM1A 0.0386976222860582 0.682018574136515 -0.332441598633123 9.27107504543357e-08 miRNATAP -0.181875705412719 5.68287548274831e-16 NA NA NA hsa-miR-542-3p PPM1A 0.568822103820889 8.5699075257651e-07 -0.332441598633123 9.27107504543357e-08 MirTarget -0.138881726731707 2.50635300668202e-14 NA NA NA hsa-miR-93-5p PPM1A 1.01788600209314 1.24312921618126e-21 -0.332441598633123 9.27107504543357e-08 mirMAP -0.185796777346844 3.7800370221847e-22 NA NA NA hsa-miR-181a-5p PPM1B 0.635863607630183 6.72486918157744e-11 -0.232519112711385 5.57129693670307e-07 mirMAP;miRNATAP -0.106731137185058 3.30256228654691e-11 NA NA NA hsa-miR-361-5p PPM1B -0.0996867547900457 0.095428250126326 -0.232519112711385 5.57129693670307e-07 miRanda -0.119627078863263 9.83030425896607e-06 NA NA NA hsa-miR-542-3p PPM1B 0.568822103820889 8.5699075257651e-07 -0.232519112711385 5.57129693670307e-07 miRanda -0.103215006415713 2.65095950433855e-14 NA NA NA hsa-let-7f-5p PPP3CA 0.12216148416417 0.221351291433294 -0.544246415257643 5.77237427579346e-09 miRNATAP -0.102194254433793 0.00165189815382032 NA NA NA hsa-miR-106b-5p PPP3CA 1.22477789913175 2.31787213143326e-32 -0.544246415257643 5.77237427579346e-09 miRNATAP -0.163746270795427 4.48730421523751e-08 NA NA NA hsa-miR-17-3p PPP3CA 0.721439431208839 7.95900548819742e-10 -0.544246415257643 5.77237427579346e-09 MirTarget -0.124078923715287 5.08318296663462e-06 NA NA NA hsa-miR-194-5p PPP3CA 0.467781870340114 1.0386810618625e-07 -0.544246415257643 5.77237427579346e-09 MirTarget -0.132376274530416 0.000303144003211118 NA NA NA hsa-miR-20a-5p PPP3CA 0.44979911120222 0.000602386964327228 -0.544246415257643 5.77237427579346e-09 miRNATAP -0.110326267376209 6.81988772591416e-06 NA NA NA hsa-miR-21-5p PPP3CA 2.32007501846389 3.08394781855554e-137 -0.544246415257643 5.77237427579346e-09 miRNATAP -0.171857455775929 3.70280677648987e-09 NA NA NA hsa-miR-340-5p PPP3CA 1.0857159627596 4.94471062546756e-24 -0.544246415257643 5.77237427579346e-09 mirMAP -0.176067551771713 1.43168876315375e-09 NA NA NA hsa-miR-361-5p PPP3CA -0.0996867547900457 0.095428250126326 -0.544246415257643 5.77237427579346e-09 miRanda -0.244052441662145 8.38230854446672e-06 NA NA NA hsa-miR-93-5p PPP3CA 1.01788600209314 1.24312921618126e-21 -0.544246415257643 5.77237427579346e-09 miRNATAP -0.162948227314112 3.15959129159339e-08 NA NA NA hsa-miR-107 PPP3CB 0.678998026350662 2.56224148930538e-16 -0.507852474824067 3.82558012937129e-19 miRanda -0.128823034238509 4.39638835494672e-08 NA NA NA hsa-miR-146b-5p PPP3CB 0.631041661167954 6.20366593452965e-08 -0.507852474824067 3.82558012937129e-19 miRanda -0.171198371090796 2.36585494803099e-25 NA NA NA hsa-miR-15a-5p PPP3CB 0.812445324157528 4.50263417099822e-20 -0.507852474824067 3.82558012937129e-19 miRNATAP -0.126089090631579 8.14069089424982e-09 NA NA NA hsa-miR-340-5p PPP3CB 1.0857159627596 4.94471062546756e-24 -0.507852474824067 3.82558012937129e-19 MirTarget -0.156446625862705 8.32036945224755e-19 NA NA NA hsa-miR-361-5p PPP3CB -0.0996867547900457 0.095428250126326 -0.507852474824067 3.82558012937129e-19 miRanda -0.218861370922051 6.00579314883281e-11 NA NA NA hsa-miR-101-3p PPP3R1 -0.126035286271986 0.145997832808138 -0.297052041419911 9.95522907099635e-08 miRNATAP -0.187171459954337 1.17776284425277e-17 NA NA NA hsa-miR-181c-5p PPP3R1 0.574847839298605 4.51287502066478e-07 -0.297052041419911 9.95522907099635e-08 MirTarget;miRNATAP -0.125950184238424 2.66954355100233e-14 NA NA NA hsa-miR-26a-5p PPP3R1 -0.481180084102235 1.82368246174758e-10 -0.297052041419911 9.95522907099635e-08 MirTarget;miRNATAP -0.15120972679612 1.94023722332139e-09 NA NA NA hsa-miR-30a-5p PPP3R1 -0.392489994825279 0.00954894667761676 -0.297052041419911 9.95522907099635e-08 miRNAWalker2_validate;MirTarget;miRNATAP -0.13382780475557 1.01801426792285e-27 NA NA NA hsa-miR-193a-5p PPP5C -1.1508321886378 7.11949564429669e-37 0.678409140831224 4.81970996779213e-39 TargetScan;miRNATAP -0.101669929030198 2.1418702146228e-07 NA NA NA hsa-miR-141-3p PRKACB 2.99777540204168 1.26370498493024e-78 -0.383846400368397 0.0117591306589187 MirTarget;TargetScan;miRNATAP -0.14986275424127 3.7367241254854e-07 NA NA NA hsa-miR-17-5p PRKACB 0.599531757298529 1.07318660415906e-05 -0.383846400368397 0.0117591306589187 TargetScan -0.167470485926017 1.11326049159611e-05 NA NA NA hsa-miR-18a-5p PRKACB 0.969066793715868 1.69069796425892e-08 -0.383846400368397 0.0117591306589187 miRNATAP -0.109828861303179 0.000270889162356874 NA NA NA hsa-miR-19a-3p PRKACB 0.817507952171848 3.76285090469625e-08 -0.383846400368397 0.0117591306589187 MirTarget;miRNATAP -0.144307019920445 3.41593280940585e-05 NA NA NA hsa-miR-19b-3p PRKACB 0.139124391010031 0.255658553872934 -0.383846400368397 0.0117591306589187 miRNAWalker2_validate;MirTarget;miRNATAP -0.13474256019019 0.00164169207970928 NA NA NA hsa-miR-200b-3p PRKACB 2.11744072703209 1.66710572104191e-43 -0.383846400368397 0.0117591306589187 MirTarget;TargetScan -0.128358992363134 6.97422500356901e-05 NA NA NA hsa-miR-200c-3p PRKACB 2.07038651806183 6.84613386286599e-51 -0.383846400368397 0.0117591306589187 MirTarget;miRNATAP -0.165596646495394 2.94921644943646e-06 NA NA NA hsa-miR-30d-3p PRKACB 0.264544633563642 0.00755023189129747 -0.383846400368397 0.0117591306589187 mirMAP -0.251818481172515 1.82407867076559e-06 NA NA NA hsa-miR-340-5p PRKACB 1.0857159627596 4.94471062546756e-24 -0.383846400368397 0.0117591306589187 mirMAP -0.151842813986032 0.001373090709035 NA NA NA hsa-miR-361-5p PRKACB -0.0996867547900457 0.095428250126326 -0.383846400368397 0.0117591306589187 miRanda -0.31917046064862 0.000326749716630808 NA NA NA hsa-miR-362-5p PRKACB -0.248676340901797 0.0726089851456282 -0.383846400368397 0.0117591306589187 PITA -0.175108655019306 3.25359783331258e-06 NA NA NA hsa-miR-532-5p PRKACB 0.0386976222860582 0.682018574136515 -0.383846400368397 0.0117591306589187 PITA -0.167904290632964 0.00255889279358267 NA NA NA hsa-miR-93-5p PRKACB 1.01788600209314 1.24312921618126e-21 -0.383846400368397 0.0117591306589187 miRNAWalker2_validate -0.337877597223658 9.95580809015501e-13 NA NA NA hsa-miR-181b-5p PRKCA 1.22749257795094 1.21998198830919e-27 -1.70723657875247 1.7688165305473e-34 mirMAP -0.11742885805708 0.0062191009662321 NA NA NA hsa-miR-181c-5p PRKCA 0.574847839298605 4.51287502066478e-07 -1.70723657875247 1.7688165305473e-34 mirMAP -0.151937361609795 0.00048559417186175 NA NA NA hsa-miR-183-5p PRKCA 2.95681814393872 1.09965777344285e-92 -1.70723657875247 1.7688165305473e-34 miRNATAP -0.382401275003301 4.39521361355191e-39 NA NA NA hsa-miR-193b-3p PRKCA -0.0550374855074773 0.65382485898551 -1.70723657875247 1.7688165305473e-34 miRNAWalker2_validate -0.158591304154604 9.61914010087921e-05 NA NA NA hsa-miR-194-5p PRKCA 0.467781870340114 1.0386810618625e-07 -1.70723657875247 1.7688165305473e-34 mirMAP -0.194734764385864 0.000579018161354159 NA NA NA hsa-miR-200b-3p PRKCA 2.11744072703209 1.66710572104191e-43 -1.70723657875247 1.7688165305473e-34 TargetScan -0.338107140907763 7.43601898887161e-30 NA NA NA hsa-miR-200c-3p PRKCA 2.07038651806183 6.84613386286599e-51 -1.70723657875247 1.7688165305473e-34 miRNATAP -0.384868851727468 4.79014422420278e-32 NA NA NA hsa-miR-29b-2-5p PRKCA -0.263499971180298 0.0400001755611965 -1.70723657875247 1.7688165305473e-34 mirMAP -0.365220324605892 6.60788568306249e-22 NA NA NA hsa-miR-30d-3p PRKCA 0.264544633563642 0.00755023189129747 -1.70723657875247 1.7688165305473e-34 mirMAP -0.185045137833304 0.000246654172160224 NA NA NA hsa-miR-339-5p PRKCA -0.211548290465418 0.0685885445822389 -1.70723657875247 1.7688165305473e-34 mirMAP -0.116903398908303 0.00661066095178211 NA NA NA hsa-miR-340-5p PRKCA 1.0857159627596 4.94471062546756e-24 -1.70723657875247 1.7688165305473e-34 mirMAP -0.157880969288124 0.000482930053726641 NA NA NA hsa-miR-375 PRKCA 2.09893673049766 1.68351780396203e-16 -1.70723657875247 1.7688165305473e-34 miRNAWalker2_validate -0.240131861837491 2.29799527522168e-39 NA NA NA hsa-miR-429 PRKCA 2.84108892259147 3.88520896426515e-64 -1.70723657875247 1.7688165305473e-34 miRanda;miRNATAP -0.302006017947741 7.14515269636082e-30 NA NA NA hsa-miR-141-5p PRKCB 2.38411349683216 4.56310582620282e-58 -0.447147877250759 0.0168049140120418 mirMAP -0.127187131565152 0.00154757873879663 NA NA NA hsa-miR-200b-3p PRKCB 2.11744072703209 1.66710572104191e-43 -0.447147877250759 0.0168049140120418 MirTarget -0.185811618752792 2.61023291805883e-06 NA NA NA hsa-miR-200c-3p PRKCB 2.07038651806183 6.84613386286599e-51 -0.447147877250759 0.0168049140120418 MirTarget;miRNATAP -0.190171510726694 1.24294313881003e-05 NA NA NA hsa-miR-29b-2-5p PRKCB -0.263499971180298 0.0400001755611965 -0.447147877250759 0.0168049140120418 mirMAP -0.248738713275143 5.96583916655133e-07 NA NA NA hsa-miR-30b-5p PRKCB -0.46540603860146 2.4709940429591e-05 -0.447147877250759 0.0168049140120418 mirMAP -0.181899501701348 0.00172429854651836 NA NA NA hsa-miR-30c-5p PRKCB -0.393222674580066 8.06961465717306e-05 -0.447147877250759 0.0168049140120418 mirMAP -0.266676621567604 3.26692465594906e-05 NA NA NA hsa-miR-30d-3p PRKCB 0.264544633563642 0.00755023189129747 -0.447147877250759 0.0168049140120418 mirMAP -0.176195796338334 0.00676988213351706 NA NA NA hsa-miR-338-3p PRKCB 0.0799903526884966 0.575137668326679 -0.447147877250759 0.0168049140120418 miRanda -0.216031823790678 1.44429456470486e-06 NA NA NA hsa-miR-429 PRKCB 2.84108892259147 3.88520896426515e-64 -0.447147877250759 0.0168049140120418 MirTarget;miRanda;miRNATAP -0.177108211107202 5.14864677602474e-07 NA NA NA hsa-miR-664a-3p PRKCB -0.237699857923843 0.0197071390183375 -0.447147877250759 0.0168049140120418 mirMAP -0.30918523276408 8.70938453871888e-07 NA NA NA hsa-miR-182-5p PRKX 2.36408084103818 2.60011457600281e-72 -0.32229806441307 0.0153896096972611 mirMAP -0.175194994974604 2.67502751484288e-08 NA NA NA hsa-miR-29b-3p PRKX 0.438847962603729 6.46722433236121e-05 -0.32229806441307 0.0153896096972611 mirMAP -0.120330213613139 0.0037387071410825 NA NA NA hsa-miR-29c-3p PRKX -0.0652732378039769 0.563774115756922 -0.32229806441307 0.0153896096972611 mirMAP -0.38827959473025 7.47361121556913e-23 NA NA NA hsa-miR-375 PRKX 2.09893673049766 1.68351780396203e-16 -0.32229806441307 0.0153896096972611 miRNAWalker2_validate;miRanda -0.207392873270567 7.07421795114455e-35 NA NA NA hsa-miR-625-3p PRKX 0.0779480073849017 0.444334811113011 -0.32229806441307 0.0153896096972611 mirMAP -0.146145038207053 0.00114969241015916 NA NA NA hsa-miR-335-5p PTPN7 -2.61355235628987 2.6462884165886e-51 1.11717276563442 3.54528943195632e-13 miRNAWalker2_validate -0.13210856069372 4.66746395404188e-06 NA NA NA hsa-miR-101-3p RAC1 -0.126035286271986 0.145997832808138 0.176628662773421 0.000153658997491136 miRNAWalker2_validate;MirTarget -0.139972978942608 1.93650351223228e-14 25202416;24649082;25057058 In previous studies the role of miRNA-101 miR-101 in tumors has been identified as a tumor suppressor and until now the role of miR-101 and Rac1 in thyroid cancer has remained undefined; Rac1 was demonstrated to be negatively regulated by miR-101 at the post-transcriptional level via a specific target site within the 3' untranslated region by dual-luciferase reporter assay; The expression of Rac1 was also observed to inversely correlate with miR-101 expression in PTC tissues; knockdown of Rac1 by shRNA inhibited thyroid cancer cell migration and invasion resembling that of miR-101 overexpression; Thus these findings suggested that miR-101 acts as a novel suppressor by targeting the Rac1 gene and inhibiting thyroid cancer cell migration and invasion;miR 101 inhibits cell proliferation by targeting Rac1 in papillary thyroid carcinoma; In the present study we investigated the role of microRNA-101 miR-101 in PTC via targeting of Ras-related C3 botulinum toxin substrate 1 Rac1; Moreover algorithm-based and experimental strategies verified Rac1 as a direct target of miR-101 in the K1 cell line; Taken together these findings suggest that miR-101 inhibited PTC growth via the downregulation of Rac1 expression providing a better understanding of miRNA-modulated signaling networks for future cancer therapeutics;Mir-101 inhibitors significantly increased the luciferase activities of RAC1 3'UTR; Overexpression of mir-101 increased the expression of RAC1 while inhibition of mir-101 suppressed RAC1 expression; mir-101 can suppress RAC1 gene expression by targeting the specific sequence of RAC1 3'UTR cell migration;; thyroid cancer;thyroid cancer;colorectal cancer hsa-miR-193b-3p RAC2 -0.0550374855074773 0.65382485898551 0.739175691283857 1.48014827234175e-09 miRNAWalker2_validate -0.163439972898065 2.05534635731132e-06 NA NA NA hsa-miR-491-5p RAC2 -1.04307210952796 1.14586501470398e-15 0.739175691283857 1.48014827234175e-09 miRanda -0.170510866222564 9.84222871672058e-08 NA NA NA hsa-miR-125a-5p RAC3 -0.635694700253268 3.6703235721638e-11 1.34875128530309 1.88353993751843e-24 PITA -0.214154670070607 8.31103753734932e-06 NA NA NA hsa-miR-3913-5p RAP1A 0.71890413546147 2.61153227160465e-13 -0.206644199882094 4.0406371408911e-05 mirMAP -0.121546969384821 1.58087504282888e-12 NA NA NA hsa-miR-106b-5p RAPGEF2 1.22477789913175 2.31787213143326e-32 -1.07954431946973 1.09869317643974e-45 MirTarget;miRNATAP -0.252954960272669 5.19239743427734e-24 NA NA NA hsa-miR-141-3p RAPGEF2 2.99777540204168 1.26370498493024e-78 -1.07954431946973 1.09869317643974e-45 MirTarget;TargetScan;miRNATAP -0.190427522928983 4.04692361635089e-37 NA NA NA hsa-miR-155-5p RAPGEF2 1.09766314984151 4.55650930885814e-15 -1.07954431946973 1.09869317643974e-45 miRNAWalker2_validate;MirTarget -0.113336778641952 3.7999484659377e-09 NA NA NA hsa-miR-15a-5p RAPGEF2 0.812445324157528 4.50263417099822e-20 -1.07954431946973 1.09869317643974e-45 miRNATAP -0.342899258068773 3.06744175511745e-31 NA NA NA hsa-miR-15b-5p RAPGEF2 0.788659356634696 1.13678211092534e-11 -1.07954431946973 1.09869317643974e-45 miRNATAP -0.118450940622669 4.07723725031684e-07 NA NA NA hsa-miR-19a-3p RAPGEF2 0.817507952171848 3.76285090469625e-08 -1.07954431946973 1.09869317643974e-45 MirTarget;miRNATAP -0.118588927801747 8.02218358351405e-11 NA NA NA hsa-miR-200a-3p RAPGEF2 2.55218480823434 2.96135446816238e-51 -1.07954431946973 1.09869317643974e-45 MirTarget;miRNATAP -0.167119036962075 1.78754985294303e-29 NA NA NA hsa-miR-200b-3p RAPGEF2 2.11744072703209 1.66710572104191e-43 -1.07954431946973 1.09869317643974e-45 MirTarget;TargetScan -0.179237551056118 2.21593713134509e-27 NA NA NA hsa-miR-200c-3p RAPGEF2 2.07038651806183 6.84613386286599e-51 -1.07954431946973 1.09869317643974e-45 MirTarget;miRNATAP -0.202553658903887 6.1626718024825e-29 NA NA NA hsa-miR-20a-5p RAPGEF2 0.44979911120222 0.000602386964327228 -1.07954431946973 1.09869317643974e-45 MirTarget;miRNATAP -0.151992641461687 2.31002548704563e-13 NA NA NA hsa-miR-27a-3p RAPGEF2 0.388496361379095 1.42373532086331e-05 -1.07954431946973 1.09869317643974e-45 MirTarget;miRNATAP -0.108734314536718 0.000419487339919895 NA NA NA hsa-miR-429 RAPGEF2 2.84108892259147 3.88520896426515e-64 -1.07954431946973 1.09869317643974e-45 MirTarget;PITA;miRanda;miRNATAP -0.17437988631643 1.29609092060223e-32 NA NA NA hsa-miR-590-3p RAPGEF2 1.27438512890514 1.03164723481469e-23 -1.07954431946973 1.09869317643974e-45 miRanda -0.123351269628208 1.96123471349299e-08 NA NA NA hsa-miR-93-5p RAPGEF2 1.01788600209314 1.24312921618126e-21 -1.07954431946973 1.09869317643974e-45 MirTarget;miRNATAP -0.257767192325044 9.85916934775099e-26 NA NA NA hsa-miR-130b-3p RASA1 1.38122163823846 1.00932179737836e-26 -0.294730586920749 0.000766494242183886 MirTarget -0.157001695187525 2.656679234595e-12 NA NA NA hsa-miR-146b-5p RASA1 0.631041661167954 6.20366593452965e-08 -0.294730586920749 0.000766494242183886 miRanda -0.203932611810145 6.33379413307804e-16 NA NA NA hsa-miR-21-5p RASA1 2.32007501846389 3.08394781855554e-137 -0.294730586920749 0.000766494242183886 miRNATAP -0.149767999849588 3.5184635352839e-08 25663768;27101583 RKO cells were transfected with vectors overexpressing or down-regulating either miR-21 or RASA1; Furthermore a luciferase reporter assay was used to determine whether RASA1 is a gene target of miR-21; RASA1 protein levels were significantly decreased in RKO cells compared with the other 5 colon cancer cell lines and RASA1 was confirmed as a target gene of miR-21; Interestingly RASA1 mRNA and protein levels in pre-miR-21-LV up-regulation of miR-21 cells were lower than those in anti-miR-21-LV down-regulation of miR-21 cells P < 0.05; RASA1 is a target gene of miR-21 which promotes malignant behaviors of RKO cells through regulation of RASA1 expression;Circulating MicroRNA 21 Is Involved in Lymph Node Metastasis in Cervical Cancer by Targeting RASA1; Then cervical cancer cell lines HeLa HPV-18 DNA E6/E7RNA and HT-3 HPV DNA E6/E7RNA were used to confirm the interaction between miR-21 and RASA1; MicroRNA-21 reduces RASA1 expression in cervical cancer cell lines and promotes cervical cancer cell migration via RASA1 malignant trasformation;metastasis;cell migration colon cancer;cervical and endocervical cancer hsa-miR-223-3p RASA1 -0.966406159689943 7.90612601654887e-12 -0.294730586920749 0.000766494242183886 MirTarget -0.105611829493872 4.47427896765755e-07 25867276 C/EBP β activated microRNA 223 promotes tumour growth through targeting RASA1 in human colorectal cancer; The levels of RASA1 and miR-223 were analysed by real-time PCR western blotting or in situ immunofluorescence analyses; Upregulation of miR-223 was detected in CRC tissues P<0.01 and was involved in downregulation of RASA1 in CRC tissues; Furthermore the direct inhibition of RASA1 translation by miR-223 and the activation of miR-223 by CCAAT/enhancer binding protein-β C/EBP-β were evaluated in CRC cells; These results identify that C/EBP-β-activated miR-223 contributes to tumour growth by targeting RASA1 in CRC and miR-223-targeted inhibitors may have clinical promise for CRC treatment via suppression of miR-223 colorectal cancer hsa-miR-24-3p RASA1 -0.120123317289941 0.21432376743243 -0.294730586920749 0.000766494242183886 MirTarget;miRNATAP -0.116393363039335 0.000190718929248217 NA NA NA hsa-miR-361-5p RASA1 -0.0996867547900457 0.095428250126326 -0.294730586920749 0.000766494242183886 miRanda -0.25940588477942 3.46447520199015e-07 NA NA NA hsa-miR-590-3p RASA1 1.27438512890514 1.03164723481469e-23 -0.294730586920749 0.000766494242183886 miRanda -0.113657556893731 2.19835293993174e-06 NA NA NA hsa-miR-590-5p RASA1 0.746515607868274 8.51300479640125e-09 -0.294730586920749 0.000766494242183886 miRNATAP -0.127710176275603 2.39199694449279e-08 NA NA NA hsa-miR-92a-3p RASA1 -0.342420481092807 0.000732275969501111 -0.294730586920749 0.000766494242183886 miRNAWalker2_validate -0.197972114017812 1.61082929422124e-11 NA NA NA hsa-miR-141-3p RASA2 2.99777540204168 1.26370498493024e-78 -0.987338236523419 4.85695047036301e-10 TargetScan -0.114558440879572 0.000231326184807738 NA NA NA hsa-miR-200b-3p RASA2 2.11744072703209 1.66710572104191e-43 -0.987338236523419 4.85695047036301e-10 TargetScan -0.116042713824606 0.000635084861671019 NA NA NA hsa-miR-125a-5p RASGRF1 -0.635694700253268 3.6703235721638e-11 0.743117588404357 0.000669318514784322 MirTarget;miRanda -0.382319549021974 7.38192594590505e-07 NA NA NA hsa-miR-139-5p RASGRF1 -3.25846663863766 2.62018989415003e-112 0.743117588404357 0.000669318514784322 MirTarget;miRanda -0.135490498006884 0.00264937757767138 NA NA NA hsa-miR-29b-2-5p RASGRF1 -0.263499971180298 0.0400001755611965 0.743117588404357 0.000669318514784322 mirMAP -0.567611118498592 2.55345673613819e-23 NA NA NA hsa-let-7a-3p RASGRF2 0.466622567891891 3.70886257943079e-07 -1.50231288432749 1.31976412389238e-25 mirMAP -0.30132867141085 4.05100292988474e-08 NA NA NA hsa-miR-106a-5p RASGRF2 0.574594373206545 0.000145868284001732 -1.50231288432749 1.31976412389238e-25 MirTarget -0.139221611908457 3.06466373890191e-05 NA NA NA hsa-miR-106b-5p RASGRF2 1.22477789913175 2.31787213143326e-32 -1.50231288432749 1.31976412389238e-25 MirTarget -0.668275349253694 4.76505202716724e-51 NA NA NA hsa-miR-132-3p RASGRF2 -0.0365213889238607 0.668598301088667 -1.50231288432749 1.31976412389238e-25 mirMAP -0.320540348787789 7.60624790957772e-08 NA NA NA hsa-miR-146b-5p RASGRF2 0.631041661167954 6.20366593452965e-08 -1.50231288432749 1.31976412389238e-25 miRanda -0.240514941866759 2.28675484666249e-08 NA NA NA hsa-miR-17-5p RASGRF2 0.599531757298529 1.07318660415906e-05 -1.50231288432749 1.31976412389238e-25 MirTarget;TargetScan -0.421485497153145 4.5074670966001e-32 NA NA NA hsa-miR-182-5p RASGRF2 2.36408084103818 2.60011457600281e-72 -1.50231288432749 1.31976412389238e-25 mirMAP -0.332608173999958 4.42625198160884e-22 NA NA NA hsa-miR-20a-5p RASGRF2 0.44979911120222 0.000602386964327228 -1.50231288432749 1.31976412389238e-25 MirTarget -0.494800335331337 3.12844113623072e-41 NA NA NA hsa-miR-30d-3p RASGRF2 0.264544633563642 0.00755023189129747 -1.50231288432749 1.31976412389238e-25 mirMAP -0.494555232364555 6.19734061181368e-23 NA NA NA hsa-miR-320b RASGRF2 0.412787504747938 0.00113457276903985 -1.50231288432749 1.31976412389238e-25 miRNATAP -0.208686805496719 1.82353808343774e-07 NA NA NA hsa-miR-324-5p RASGRF2 0.211552647440779 0.139408130311654 -1.50231288432749 1.31976412389238e-25 miRNATAP -0.185725603372822 1.44152524752021e-07 NA NA NA hsa-miR-330-3p RASGRF2 0.432728362037032 0.00041335506960812 -1.50231288432749 1.31976412389238e-25 mirMAP -0.213211207472309 3.29302050130744e-07 NA NA NA hsa-miR-429 RASGRF2 2.84108892259147 3.88520896426515e-64 -1.50231288432749 1.31976412389238e-25 miRanda -0.374968653023569 2.6237327482128e-45 NA NA NA hsa-miR-590-3p RASGRF2 1.27438512890514 1.03164723481469e-23 -1.50231288432749 1.31976412389238e-25 MirTarget;miRanda -0.359075593709517 2.04366570773543e-19 NA NA NA hsa-miR-590-5p RASGRF2 0.746515607868274 8.51300479640125e-09 -1.50231288432749 1.31976412389238e-25 miRanda -0.326677798408005 1.14170926955472e-17 NA NA NA hsa-miR-93-5p RASGRF2 1.01788600209314 1.24312921618126e-21 -1.50231288432749 1.31976412389238e-25 MirTarget -0.672023575826152 1.50545432642199e-53 NA NA NA hsa-miR-486-5p RASGRP1 -3.87258704301474 1.22658629378451e-80 0.973407990771331 1.43757924621451e-07 miRanda -0.106236099814952 0.000171212137177818 NA NA NA hsa-miR-758-3p RASGRP1 -0.968261853361846 4.7142782277017e-12 0.973407990771331 1.43757924621451e-07 MirTarget -0.118953001204405 0.00845960520405056 NA NA NA hsa-miR-324-3p RASGRP2 0.404877731996915 0.000340036423920834 -1.0884359274312 5.62935468005693e-10 PITA -0.426569825202945 7.49847398087328e-16 NA NA NA hsa-miR-484 RASGRP2 0.349444060004737 0.00154491249625173 -1.0884359274312 5.62935468005693e-10 PITA -0.437929458450205 6.73502282336069e-16 NA NA NA hsa-miR-30b-3p RASGRP4 -0.536462824497982 2.41814659272548e-05 -0.655281786974586 6.53684341783125e-09 MirTarget -0.179467867827442 4.45509637425569e-09 NA NA NA hsa-miR-491-5p RELB -1.04307210952796 1.14586501470398e-15 0.883073704327104 2.10221009080292e-17 miRanda -0.192570395706725 1.85094526168156e-12 NA NA NA hsa-miR-125a-5p RPS6KA1 -0.635694700253268 3.6703235721638e-11 1.00256510904029 1.46599111482776e-34 MirTarget;PITA;miRanda -0.106622289814942 0.000408128374437011 NA NA NA hsa-miR-125b-5p RPS6KA1 -1.94393269763542 2.78180543229264e-58 1.00256510904029 1.46599111482776e-34 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.138027596245383 6.3071430728344e-10 NA NA NA hsa-miR-139-5p RPS6KA1 -3.25846663863766 2.62018989415003e-112 1.00256510904029 1.46599111482776e-34 miRanda -0.156690112707771 7.04064981880923e-20 NA NA NA hsa-miR-335-3p RPS6KA1 -1.88448538773649 2.09538234398335e-32 1.00256510904029 1.46599111482776e-34 MirTarget -0.144963406126286 6.42280497225378e-17 NA NA NA hsa-let-7g-3p RPS6KA2 0.5854327663695 0.000371711766083627 -1.06112701609507 1.34339346025472e-29 MirTarget -0.111600921985962 2.77540875129883e-08 NA NA NA hsa-miR-130b-5p RPS6KA2 1.0573161199584 2.55177349228739e-12 -1.06112701609507 1.34339346025472e-29 mirMAP -0.171926517516172 1.08296122809856e-15 NA NA NA hsa-miR-17-5p RPS6KA2 0.599531757298529 1.07318660415906e-05 -1.06112701609507 1.34339346025472e-29 TargetScan -0.222822755541125 9.19238138746822e-21 NA NA NA hsa-miR-185-3p RPS6KA2 0.86591374114446 7.8790769678542e-10 -1.06112701609507 1.34339346025472e-29 MirTarget -0.148831770250574 2.9912494378753e-10 NA NA NA hsa-miR-193a-3p RPS6KA2 0.310617999804917 0.00477640270974957 -1.06112701609507 1.34339346025472e-29 mirMAP -0.173249397713506 8.96777762296435e-09 NA NA NA hsa-miR-19a-3p RPS6KA2 0.817507952171848 3.76285090469625e-08 -1.06112701609507 1.34339346025472e-29 MirTarget -0.179126566533993 2.87975380365162e-16 NA NA NA hsa-miR-19b-3p RPS6KA2 0.139124391010031 0.255658553872934 -1.06112701609507 1.34339346025472e-29 MirTarget -0.161006226162469 2.86515716406055e-09 NA NA NA hsa-miR-200b-3p RPS6KA2 2.11744072703209 1.66710572104191e-43 -1.06112701609507 1.34339346025472e-29 TargetScan -0.19593222828491 2.13416782438513e-22 NA NA NA hsa-miR-200c-3p RPS6KA2 2.07038651806183 6.84613386286599e-51 -1.06112701609507 1.34339346025472e-29 miRNATAP -0.281022132531582 1.82177016356237e-38 NA NA NA hsa-miR-21-3p RPS6KA2 2.17476065946878 5.15299442583591e-75 -1.06112701609507 1.34339346025472e-29 MirTarget -0.24334264336363 1.98040233570223e-22 NA NA NA hsa-miR-30b-5p RPS6KA2 -0.46540603860146 2.4709940429591e-05 -1.06112701609507 1.34339346025472e-29 MirTarget -0.110298603171651 0.000253431254273401 NA NA NA hsa-miR-30d-5p RPS6KA2 -0.247082219011045 0.00406717930063148 -1.06112701609507 1.34339346025472e-29 MirTarget;miRNATAP -0.148759301389742 0.000132297251897939 NA NA NA hsa-miR-30e-5p RPS6KA2 0.293491764699475 0.000372291967271834 -1.06112701609507 1.34339346025472e-29 MirTarget -0.213399770733942 1.2882063036701e-07 NA NA NA hsa-miR-3127-5p RPS6KA2 0.903405128081314 1.1325923598273e-12 -1.06112701609507 1.34339346025472e-29 mirMAP -0.254813783564397 6.3212055626234e-24 NA NA NA hsa-miR-429 RPS6KA2 2.84108892259147 3.88520896426515e-64 -1.06112701609507 1.34339346025472e-29 miRanda;miRNATAP -0.191117874968675 1.07705854301622e-26 NA NA NA hsa-miR-589-5p RPS6KA2 0.367182541239722 1.67804815542873e-05 -1.06112701609507 1.34339346025472e-29 mirMAP -0.294301339039086 2.54864043107873e-14 NA NA NA hsa-miR-93-3p RPS6KA2 0.627759242044891 3.62527588304617e-06 -1.06112701609507 1.34339346025472e-29 MirTarget -0.194961316172869 5.99811603663702e-16 NA NA NA hsa-let-7e-5p RPS6KA3 0.261471269338985 0.00191077095550257 -1.37237205082117 2.11044411412942e-35 miRNATAP -0.157060484548625 0.000871275403936363 NA NA NA hsa-miR-103a-3p RPS6KA3 0.610673390034345 1.63113920514646e-12 -1.37237205082117 2.11044411412942e-35 MirTarget -0.445736137422984 6.6306047939867e-24 NA NA NA hsa-miR-106b-5p RPS6KA3 1.22477789913175 2.31787213143326e-32 -1.37237205082117 2.11044411412942e-35 miRNATAP -0.162439827717479 1.00251039325415e-05 NA NA NA hsa-miR-107 RPS6KA3 0.678998026350662 2.56224148930538e-16 -1.37237205082117 2.11044411412942e-35 MirTarget;PITA;miRanda;miRNATAP -0.265777635777206 1.41892389468232e-08 NA NA NA hsa-miR-15a-5p RPS6KA3 0.812445324157528 4.50263417099822e-20 -1.37237205082117 2.11044411412942e-35 MirTarget;miRNATAP -0.358183106164086 9.94945208595321e-17 NA NA NA hsa-miR-181a-5p RPS6KA3 0.635863607630183 6.72486918157744e-11 -1.37237205082117 2.11044411412942e-35 MirTarget;mirMAP;miRNATAP -0.197115676665566 9.09685071705532e-07 NA NA NA hsa-miR-181b-5p RPS6KA3 1.22749257795094 1.21998198830919e-27 -1.37237205082117 2.11044411412942e-35 MirTarget;mirMAP;miRNATAP -0.207881783481224 7.32003086534495e-10 NA NA NA hsa-miR-181c-5p RPS6KA3 0.574847839298605 4.51287502066478e-07 -1.37237205082117 2.11044411412942e-35 MirTarget;mirMAP;miRNATAP -0.121420661637188 0.000442040350968237 NA NA NA hsa-miR-181d-5p RPS6KA3 0.782618466877349 1.2821116358212e-09 -1.37237205082117 2.11044411412942e-35 MirTarget -0.126354396119077 3.1383002502487e-05 NA NA NA hsa-miR-183-5p RPS6KA3 2.95681814393872 1.09965777344285e-92 -1.37237205082117 2.11044411412942e-35 MirTarget;miRNATAP -0.221655186837094 1.11615961728505e-20 NA NA NA hsa-miR-200b-3p RPS6KA3 2.11744072703209 1.66710572104191e-43 -1.37237205082117 2.11044411412942e-35 MirTarget;TargetScan -0.241869137597393 3.09939082839428e-24 NA NA NA hsa-miR-200c-3p RPS6KA3 2.07038651806183 6.84613386286599e-51 -1.37237205082117 2.11044411412942e-35 MirTarget;miRNATAP -0.26058220909184 2.84165141998717e-23 NA NA NA hsa-miR-21-5p RPS6KA3 2.32007501846389 3.08394781855554e-137 -1.37237205082117 2.11044411412942e-35 miRNAWalker2_validate;mirMAP;miRNATAP -0.318123624363205 1.65398865078165e-19 NA NA NA hsa-miR-29b-2-5p RPS6KA3 -0.263499971180298 0.0400001755611965 -1.37237205082117 2.11044411412942e-35 mirMAP -0.163218321920653 1.05519620181758e-07 NA NA NA hsa-miR-30d-3p RPS6KA3 0.264544633563642 0.00755023189129747 -1.37237205082117 2.11044411412942e-35 mirMAP -0.110742420352922 0.00578076092410611 NA NA NA hsa-miR-340-5p RPS6KA3 1.0857159627596 4.94471062546756e-24 -1.37237205082117 2.11044411412942e-35 mirMAP -0.187838161869725 1.46589562184612e-07 NA NA NA hsa-miR-429 RPS6KA3 2.84108892259147 3.88520896426515e-64 -1.37237205082117 2.11044411412942e-35 MirTarget;PITA;miRanda;miRNATAP -0.220289857421514 3.31100891599358e-25 NA NA NA hsa-miR-93-5p RPS6KA3 1.01788600209314 1.24312921618126e-21 -1.37237205082117 2.11044411412942e-35 miRNATAP -0.21802591930108 1.4162839807829e-09 NA NA NA hsa-miR-193a-5p RPS6KA4 -1.1508321886378 7.11949564429669e-37 0.564835045163318 2.91803903145565e-12 PITA -0.112101668908984 0.000157582839804012 NA NA NA hsa-miR-106b-5p RPS6KA5 1.22477789913175 2.31787213143326e-32 -0.957245810152851 9.30300768011881e-15 MirTarget -0.421049904430568 2.54672708914805e-27 NA NA NA hsa-miR-107 RPS6KA5 0.678998026350662 2.56224148930538e-16 -0.957245810152851 9.30300768011881e-15 miRanda -0.404244372085897 1.21332847118918e-15 NA NA NA hsa-miR-128-3p RPS6KA5 0.90296715955238 9.925204823863e-23 -0.957245810152851 9.30300768011881e-15 miRNAWalker2_validate;MirTarget -0.328500457130653 3.53414568600708e-13 NA NA NA hsa-miR-130b-3p RPS6KA5 1.38122163823846 1.00932179737836e-26 -0.957245810152851 9.30300768011881e-15 MirTarget -0.255073516295642 1.56071868032921e-15 NA NA NA hsa-miR-142-5p RPS6KA5 1.16509303143593 1.96641162209073e-13 -0.957245810152851 9.30300768011881e-15 MirTarget;PITA;mirMAP;miRNATAP -0.108727779307052 4.64549573846482e-05 NA NA NA hsa-miR-17-5p RPS6KA5 0.599531757298529 1.07318660415906e-05 -0.957245810152851 9.30300768011881e-15 MirTarget;TargetScan -0.283861497330741 2.98697815722827e-20 NA NA NA hsa-miR-18a-5p RPS6KA5 0.969066793715868 1.69069796425892e-08 -0.957245810152851 9.30300768011881e-15 MirTarget -0.304839062313663 1.17673769849974e-37 NA NA NA hsa-miR-19a-3p RPS6KA5 0.817507952171848 3.76285090469625e-08 -0.957245810152851 9.30300768011881e-15 miRNAWalker2_validate;MirTarget -0.244710469137084 3.97231002877077e-18 NA NA NA hsa-miR-19b-3p RPS6KA5 0.139124391010031 0.255658553872934 -0.957245810152851 9.30300768011881e-15 MirTarget -0.200106566424413 1.09129203989307e-08 NA NA NA hsa-miR-20a-5p RPS6KA5 0.44979911120222 0.000602386964327228 -0.957245810152851 9.30300768011881e-15 MirTarget -0.357007182065465 1.83337049286795e-29 NA NA NA hsa-miR-27a-3p RPS6KA5 0.388496361379095 1.42373532086331e-05 -0.957245810152851 9.30300768011881e-15 miRNAWalker2_validate;MirTarget;miRNATAP -0.3644473821031 1.57338554407526e-14 NA NA NA hsa-miR-27b-3p RPS6KA5 -0.0796803270437447 0.410503155574393 -0.957245810152851 9.30300768011881e-15 MirTarget;miRNATAP -0.126335572995288 0.00472139119057141 NA NA NA hsa-miR-28-5p RPS6KA5 -0.14267073663385 0.0497619246260571 -0.957245810152851 9.30300768011881e-15 miRanda -0.174299109370714 0.00356769791900598 NA NA NA hsa-miR-301a-3p RPS6KA5 1.32170168375632 2.12280368957514e-15 -0.957245810152851 9.30300768011881e-15 MirTarget -0.164384416135025 8.3794124104287e-11 NA NA NA hsa-miR-331-5p RPS6KA5 0.682437632502949 4.10871642662371e-11 -0.957245810152851 9.30300768011881e-15 PITA -0.128053145402977 0.00198925517237408 NA NA NA hsa-miR-340-5p RPS6KA5 1.0857159627596 4.94471062546756e-24 -0.957245810152851 9.30300768011881e-15 MirTarget -0.288947562043836 6.60425561874486e-14 NA NA NA hsa-miR-454-3p RPS6KA5 1.28177672191095 6.84024979484587e-21 -0.957245810152851 9.30300768011881e-15 MirTarget -0.170639515653708 2.85123144769256e-08 NA NA NA hsa-miR-590-3p RPS6KA5 1.27438512890514 1.03164723481469e-23 -0.957245810152851 9.30300768011881e-15 miRanda -0.207308482842253 1.38509524995858e-09 NA NA NA hsa-miR-93-5p RPS6KA5 1.01788600209314 1.24312921618126e-21 -0.957245810152851 9.30300768011881e-15 miRNAWalker2_validate;MirTarget -0.416250528066542 1.44198081944263e-27 NA NA NA hsa-miR-942-5p RPS6KA5 0.0274758353801279 0.842368857038259 -0.957245810152851 9.30300768011881e-15 MirTarget -0.116731015743642 0.000187124106275122 NA NA NA hsa-miR-15a-5p RPS6KA6 0.812445324157528 4.50263417099822e-20 -0.511255169559984 0.0373906669865375 MirTarget -0.637819902436688 5.07170804664232e-12 NA NA NA hsa-miR-15b-5p RPS6KA6 0.788659356634696 1.13678211092534e-11 -0.511255169559984 0.0373906669865375 MirTarget -0.228976933141519 0.00141289791914474 NA NA NA hsa-miR-17-5p RPS6KA6 0.599531757298529 1.07318660415906e-05 -0.511255169559984 0.0373906669865375 TargetScan -0.235591344457259 0.000128008040272393 NA NA NA hsa-miR-19a-3p RPS6KA6 0.817507952171848 3.76285090469625e-08 -0.511255169559984 0.0373906669865375 MirTarget -0.194741831996197 0.000530948142416833 NA NA NA hsa-miR-374a-5p RPS6KA6 -0.239709888246804 0.00309819667153627 -0.511255169559984 0.0373906669865375 MirTarget -0.351158498776282 0.000779488589640656 NA NA NA hsa-miR-374b-5p RPS6KA6 -0.466781429946153 1.17238311619116e-08 -0.511255169559984 0.0373906669865375 MirTarget -0.266178330056691 0.00967645872612687 NA NA NA hsa-miR-532-5p RPS6KA6 0.0386976222860582 0.682018574136515 -0.511255169559984 0.0373906669865375 MirTarget;PITA;miRNATAP -0.493703576177767 3.0511809768509e-08 NA NA NA hsa-miR-590-3p RPS6KA6 1.27438512890514 1.03164723481469e-23 -0.511255169559984 0.0373906669865375 MirTarget;miRanda;mirMAP;miRNATAP -0.324054984263013 1.44112437247895e-06 NA NA NA hsa-miR-889-3p RPS6KA6 -0.377352927733213 0.00501260024755438 -0.511255169559984 0.0373906669865375 MirTarget -0.194094317734353 0.00198895476553661 NA NA NA hsa-miR-29b-3p RRAS2 0.438847962603729 6.46722433236121e-05 -1.34328469535129 7.92387097337765e-28 miRNATAP -0.1353086916827 0.000630070720017472 NA NA NA hsa-miR-29c-3p RRAS2 -0.0652732378039769 0.563774115756922 -1.34328469535129 7.92387097337765e-28 miRNATAP -0.275043338749693 5.7212064860036e-13 NA NA NA hsa-miR-429 RRAS2 2.84108892259147 3.88520896426515e-64 -1.34328469535129 7.92387097337765e-28 PITA;miRanda -0.157362353521412 3.91853907751419e-11 NA NA NA hsa-miR-107 SOS1 0.678998026350662 2.56224148930538e-16 -0.877855751541721 1.03695500778597e-32 miRNATAP -0.147394654065725 2.31192726053177e-06 NA NA NA hsa-miR-16-1-3p SOS1 1.30142784811196 2.53343713753744e-29 -0.877855751541721 1.03695500778597e-32 mirMAP -0.107043157753765 3.80189774791566e-06 NA NA NA hsa-miR-181a-5p SOS1 0.635863607630183 6.72486918157744e-11 -0.877855751541721 1.03695500778597e-32 MirTarget;miRNATAP -0.159742255037842 1.79079079153389e-09 NA NA NA hsa-miR-181b-5p SOS1 1.22749257795094 1.21998198830919e-27 -0.877855751541721 1.03695500778597e-32 MirTarget;miRNATAP -0.145535984933139 7.83280749467566e-11 NA NA NA hsa-miR-181c-5p SOS1 0.574847839298605 4.51287502066478e-07 -0.877855751541721 1.03695500778597e-32 MirTarget;miRNATAP -0.128681631990538 1.68288122680838e-08 NA NA NA hsa-miR-181d-5p SOS1 0.782618466877349 1.2821116358212e-09 -0.877855751541721 1.03695500778597e-32 MirTarget -0.116569643832434 6.10109884911499e-09 NA NA NA hsa-miR-182-5p SOS1 2.36408084103818 2.60011457600281e-72 -0.877855751541721 1.03695500778597e-32 miRNATAP -0.133258609259375 1.37594627633909e-13 NA NA NA hsa-miR-361-5p SOS1 -0.0996867547900457 0.095428250126326 -0.877855751541721 1.03695500778597e-32 miRanda -0.165292469967548 0.000212244095536951 NA NA NA hsa-miR-429 SOS1 2.84108892259147 3.88520896426515e-64 -0.877855751541721 1.03695500778597e-32 miRanda;miRNATAP -0.114619423820961 9.86568637608249e-16 NA NA NA hsa-miR-542-3p SOS1 0.568822103820889 8.5699075257651e-07 -0.877855751541721 1.03695500778597e-32 miRanda -0.156663695721104 2.52964146595814e-12 NA NA NA hsa-miR-96-5p SOS1 3.24596558166606 1.92296159041707e-98 -0.877855751541721 1.03695500778597e-32 TargetScan;miRNATAP -0.114957974727393 1.33288008849377e-14 NA NA NA hsa-miR-130b-3p SOS2 1.38122163823846 1.00932179737836e-26 -0.693584357428233 2.85648006434693e-23 miRNATAP -0.109371088184118 2.82016388666753e-09 NA NA NA hsa-miR-146b-5p SOS2 0.631041661167954 6.20366593452965e-08 -0.693584357428233 2.85648006434693e-23 miRanda -0.18410115041905 2.89003141851973e-19 NA NA NA hsa-miR-15a-5p SOS2 0.812445324157528 4.50263417099822e-20 -0.693584357428233 2.85648006434693e-23 miRNATAP -0.260459131538532 1.04889039594078e-22 NA NA NA hsa-miR-21-5p SOS2 2.32007501846389 3.08394781855554e-137 -0.693584357428233 2.85648006434693e-23 miRNATAP -0.267389788495656 7.45996997519246e-36 NA NA NA hsa-miR-148b-3p SRF 1.0552576751879 1.6679285705231e-29 -0.414569756408626 1.82567718697938e-09 mirMAP -0.180996979037813 1.04284776424205e-13 NA NA NA hsa-miR-331-3p SRF 0.74441480542886 1.17071235477799e-07 -0.414569756408626 1.82567718697938e-09 miRNAWalker2_validate;mirMAP;miRNATAP -0.120911115613783 3.5273234485926e-13 NA NA NA hsa-miR-342-3p SRF 1.21944481975657 6.81914373001202e-19 -0.414569756408626 1.82567718697938e-09 PITA;miRanda -0.14299360426747 9.14773704987504e-18 NA NA NA hsa-miR-625-5p SRF 0.728939236913178 5.97591217674307e-08 -0.414569756408626 1.82567718697938e-09 MirTarget;mirMAP -0.124881934691529 3.55139242836515e-12 NA NA NA hsa-miR-361-5p STK4 -0.0996867547900457 0.095428250126326 0.174560984522386 0.00453493886022429 mirMAP -0.113189353242031 0.00157853348428608 NA NA NA hsa-miR-101-3p STMN1 -0.126035286271986 0.145997832808138 1.51200856817845 5.00282620356561e-37 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.206488142431526 2.95441587979858e-05 NA NA NA hsa-miR-139-5p STMN1 -3.25846663863766 2.62018989415003e-112 1.51200856817845 5.00282620356561e-37 miRanda -0.33498087386875 3.46506333135609e-43 NA NA NA hsa-miR-199a-5p STMN1 -0.314703593105081 0.00909304983051124 1.51200856817845 5.00282620356561e-37 miRanda -0.294071773797758 2.66081445424217e-17 NA NA NA hsa-miR-199b-5p STMN1 -1.37022396448377 3.25758057539223e-26 1.51200856817845 5.00282620356561e-37 miRanda -0.325095602582006 1.26338057505946e-25 NA NA NA hsa-miR-26a-5p STMN1 -0.481180084102235 1.82368246174758e-10 1.51200856817845 5.00282620356561e-37 miRNATAP -0.295578654201372 1.3958477274648e-07 NA NA NA hsa-miR-30a-5p STMN1 -0.392489994825279 0.00954894667761676 1.51200856817845 5.00282620356561e-37 miRNAWalker2_validate -0.220284724118633 1.87166775321937e-15 NA NA NA hsa-miR-34c-5p STMN1 -0.0896438810345765 0.557016551646841 1.51200856817845 5.00282620356561e-37 miRanda -0.178376115109944 1.46231792176924e-10 NA NA NA hsa-miR-106b-5p TAOK1 1.22477789913175 2.31787213143326e-32 -1.02699433731773 5.06740042441332e-08 miRNATAP -0.507815363125686 1.57345941062925e-17 NA NA NA hsa-miR-140-3p TAOK1 -1.25844395244141 5.29222651039892e-33 -1.02699433731773 5.06740042441332e-08 mirMAP -0.316447298082481 9.49017800864487e-08 NA NA NA hsa-miR-148a-5p TAOK1 0.572692271754695 2.14306251522796e-06 -1.02699433731773 5.06740042441332e-08 mirMAP -0.290209420854102 5.37003781680781e-08 NA NA NA hsa-miR-15a-5p TAOK1 0.812445324157528 4.50263417099822e-20 -1.02699433731773 5.06740042441332e-08 MirTarget -0.685528444055849 2.2105092551722e-22 NA NA NA hsa-miR-17-5p TAOK1 0.599531757298529 1.07318660415906e-05 -1.02699433731773 5.06740042441332e-08 TargetScan;miRNATAP -0.178344606386514 0.000176586480502379 NA NA NA hsa-miR-181a-5p TAOK1 0.635863607630183 6.72486918157744e-11 -1.02699433731773 5.06740042441332e-08 mirMAP;miRNATAP -0.461832805612015 1.87861325291914e-12 NA NA NA hsa-miR-181b-5p TAOK1 1.22749257795094 1.21998198830919e-27 -1.02699433731773 5.06740042441332e-08 mirMAP;miRNATAP -0.412769965228793 8.01004360435263e-14 NA NA NA hsa-miR-181c-5p TAOK1 0.574847839298605 4.51287502066478e-07 -1.02699433731773 5.06740042441332e-08 mirMAP;miRNATAP -0.333537394662204 3.55023814834419e-09 NA NA NA hsa-miR-185-5p TAOK1 0.482334746589337 3.68475879959415e-09 -1.02699433731773 5.06740042441332e-08 mirMAP -0.453525224530462 9.08640005452886e-09 NA NA NA hsa-miR-18a-5p TAOK1 0.969066793715868 1.69069796425892e-08 -1.02699433731773 5.06740042441332e-08 MirTarget;miRNATAP -0.242306979841869 7.7801284064685e-11 NA NA NA hsa-miR-19a-3p TAOK1 0.817507952171848 3.76285090469625e-08 -1.02699433731773 5.06740042441332e-08 MirTarget;miRNATAP -0.253645587011759 4.1863509971017e-09 NA NA NA hsa-miR-19b-3p TAOK1 0.139124391010031 0.255658553872934 -1.02699433731773 5.06740042441332e-08 MirTarget;miRNATAP -0.225733013814529 2.19445806475523e-05 NA NA NA hsa-miR-200b-3p TAOK1 2.11744072703209 1.66710572104191e-43 -1.02699433731773 5.06740042441332e-08 MirTarget;TargetScan;mirMAP -0.220708220833645 3.52423430114308e-08 NA NA NA hsa-miR-200c-3p TAOK1 2.07038651806183 6.84613386286599e-51 -1.02699433731773 5.06740042441332e-08 MirTarget;mirMAP;miRNATAP -0.172415220398364 9.65606194605702e-05 NA NA NA hsa-miR-20a-5p TAOK1 0.44979911120222 0.000602386964327228 -1.02699433731773 5.06740042441332e-08 miRNATAP -0.432041524278286 6.0010992442255e-19 NA NA NA hsa-miR-221-3p TAOK1 -0.317970198201501 0.00910855267413448 -1.02699433731773 5.06740042441332e-08 miRNATAP -0.295261963575208 2.6972697488059e-08 NA NA NA hsa-miR-26a-5p TAOK1 -0.481180084102235 1.82368246174758e-10 -1.02699433731773 5.06740042441332e-08 mirMAP;miRNATAP -0.337670843698201 8.5612860435101e-05 NA NA NA hsa-miR-27a-3p TAOK1 0.388496361379095 1.42373532086331e-05 -1.02699433731773 5.06740042441332e-08 MirTarget -0.270129012716078 0.0002039360733636 NA NA NA hsa-miR-27b-3p TAOK1 -0.0796803270437447 0.410503155574393 -1.02699433731773 5.06740042441332e-08 MirTarget -0.19670605532357 0.00363026180715099 NA NA NA hsa-miR-29a-3p TAOK1 -0.699539666833076 1.13935003139957e-13 -1.02699433731773 5.06740042441332e-08 mirMAP -0.350900554429577 2.50228403660843e-07 NA NA NA hsa-miR-29c-3p TAOK1 -0.0652732378039769 0.563774115756922 -1.02699433731773 5.06740042441332e-08 mirMAP -0.276390524657399 1.56278389135256e-06 NA NA NA hsa-miR-30a-5p TAOK1 -0.392489994825279 0.00954894667761676 -1.02699433731773 5.06740042441332e-08 MirTarget;miRNATAP -0.141846962961417 0.000954693163264327 NA NA NA hsa-miR-320a TAOK1 -0.287921276129346 0.00141693637596294 -1.02699433731773 5.06740042441332e-08 mirMAP;miRNATAP -0.299823267440813 3.33563387478858e-05 NA NA NA hsa-miR-340-5p TAOK1 1.0857159627596 4.94471062546756e-24 -1.02699433731773 5.06740042441332e-08 mirMAP -0.486457682860569 5.46565929394642e-17 NA NA NA hsa-miR-34c-3p TAOK1 0.213037310586265 0.144107566901292 -1.02699433731773 5.06740042441332e-08 mirMAP -0.120496572874847 0.00805811429498616 NA NA NA hsa-miR-34c-5p TAOK1 -0.0896438810345765 0.557016551646841 -1.02699433731773 5.06740042441332e-08 miRanda -0.151891701559095 0.000389962592007923 NA NA NA hsa-miR-369-3p TAOK1 0.0880848299432269 0.48519534195924 -1.02699433731773 5.06740042441332e-08 MirTarget;miRNATAP -0.165135663751789 0.00148704092755728 NA NA NA hsa-miR-374a-3p TAOK1 0.34122393953022 2.28714105382856e-05 -1.02699433731773 5.06740042441332e-08 mirMAP -0.306161171045681 0.00015615160084389 NA NA NA hsa-miR-374a-5p TAOK1 -0.239709888246804 0.00309819667153627 -1.02699433731773 5.06740042441332e-08 mirMAP -0.33627744454826 3.04629355572021e-05 NA NA NA hsa-miR-429 TAOK1 2.84108892259147 3.88520896426515e-64 -1.02699433731773 5.06740042441332e-08 MirTarget;mirMAP;miRNATAP -0.210385158373156 3.79964347855044e-09 NA NA NA hsa-miR-455-5p TAOK1 0.284641224662773 0.0357572339594277 -1.02699433731773 5.06740042441332e-08 MirTarget;miRNATAP -0.398809123050824 3.02339849137006e-17 NA NA NA hsa-miR-542-3p TAOK1 0.568822103820889 8.5699075257651e-07 -1.02699433731773 5.06740042441332e-08 miRanda -0.316352333622867 1.38699554348889e-08 NA NA NA hsa-miR-93-5p TAOK1 1.01788600209314 1.24312921618126e-21 -1.02699433731773 5.06740042441332e-08 miRNATAP -0.483677496002684 1.79084690959384e-16 NA NA NA hsa-miR-96-5p TAOK1 3.24596558166606 1.92296159041707e-98 -1.02699433731773 5.06740042441332e-08 miRNAWalker2_validate;TargetScan;miRNATAP -0.170489830318717 5.21335545807262e-06 NA NA NA hsa-miR-17-5p TAOK2 0.599531757298529 1.07318660415906e-05 0.433430948462074 3.95755269074194e-12 TargetScan -0.11902723255065 2.39686020761695e-14 NA NA NA hsa-miR-28-3p TAOK2 -0.815347900986328 3.29387468083828e-30 0.433430948462074 3.95755269074194e-12 PITA -0.292807349831553 1.99239383072334e-24 NA NA NA hsa-miR-28-5p TAOK2 -0.14267073663385 0.0497619246260571 0.433430948462074 3.95755269074194e-12 miRanda -0.25995291139941 1.14651902610124e-18 NA NA NA hsa-miR-491-5p TAOK2 -1.04307210952796 1.14586501470398e-15 0.433430948462074 3.95755269074194e-12 miRanda -0.109440957445309 1.84466812740148e-11 NA NA NA hsa-miR-92a-3p TAOK2 -0.342420481092807 0.000732275969501111 0.433430948462074 3.95755269074194e-12 miRNAWalker2_validate -0.206138530615459 4.37519045918653e-23 NA NA NA hsa-miR-106b-5p TAOK3 1.22477789913175 2.31787213143326e-32 -0.0997061412913478 0.094834962825228 MirTarget -0.102832086370392 5.39382470675258e-08 NA NA NA hsa-miR-107 TAOK3 0.678998026350662 2.56224148930538e-16 -0.0997061412913478 0.094834962825228 miRanda -0.108624738589844 7.51497724022426e-06 NA NA NA hsa-miR-361-5p TAOK3 -0.0996867547900457 0.095428250126326 -0.0997061412913478 0.094834962825228 miRanda -0.171809281659199 6.62428418070009e-07 NA NA NA hsa-miR-93-5p TAOK3 1.01788600209314 1.24312921618126e-21 -0.0997061412913478 0.094834962825228 MirTarget -0.12381310301614 2.35774662361942e-11 NA NA NA hsa-miR-744-5p TGFB1 0.114590984077262 0.312916425462546 0.9572932995293 2.60884198670166e-26 miRNAWalker2_validate;miRNATAP -0.166126823806423 2.82828117413693e-09 NA NA NA hsa-miR-107 TGFB2 0.678998026350662 2.56224148930538e-16 -0.568239705690126 0.00206510120463672 miRanda -0.401875565283925 8.76701815465238e-08 NA NA NA hsa-miR-141-3p TGFB2 2.99777540204168 1.26370498493024e-78 -0.568239705690126 0.00206510120463672 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.201139839320628 1.72029232417547e-08 NA NA NA hsa-miR-148b-3p TGFB2 1.0552576751879 1.6679285705231e-29 -0.568239705690126 0.00206510120463672 MirTarget -0.422618628558287 7.82755899138552e-11 NA NA NA hsa-miR-149-5p TGFB2 0.218233101703391 0.261629158371175 -0.568239705690126 0.00206510120463672 MirTarget;miRNATAP -0.129221359501958 7.02534131250114e-05 NA NA NA hsa-miR-193a-3p TGFB2 0.310617999804917 0.00477640270974957 -0.568239705690126 0.00206510120463672 MirTarget;miRanda;miRNATAP -0.385790006047712 1.31529188795393e-11 NA NA NA hsa-miR-193b-3p TGFB2 -0.0550374855074773 0.65382485898551 -0.568239705690126 0.00206510120463672 MirTarget;miRNATAP -0.171503498781225 0.000913844156376696 NA NA NA hsa-miR-200a-3p TGFB2 2.55218480823434 2.96135446816238e-51 -0.568239705690126 0.00206510120463672 MirTarget;miRNATAP -0.157197308079383 7.61768751897913e-06 25813153 Tumor suppressive microRNA 200a inhibits renal cell carcinoma development by directly targeting TGFB2; By performing quantitative real-time PCR ELISA and luciferase reporter assays transforming growth factor beta2 TGFB2 was validated as a direct target gene of miR-200a; Moreover siRNA-mediated knockdown of TGFB2 partially phenocopied the effect of miR-200a overexpression; These results suggest that miR-200a suppresses RCC development via directly targeting TGFB2 indicating that miR-200a may present a novel target for diagnostic and therapeutic strategies in RCC kidney renal cell cancer hsa-miR-29b-3p TGFB2 0.438847962603729 6.46722433236121e-05 -0.568239705690126 0.00206510120463672 miRTarBase;MirTarget;miRNATAP -0.435812547346718 1.64777033866721e-14 NA NA NA hsa-miR-29c-3p TGFB2 -0.0652732378039769 0.563774115756922 -0.568239705690126 0.00206510120463672 MirTarget;miRNATAP -0.393270636676739 1.42982951467692e-12 NA NA NA hsa-miR-301a-3p TGFB2 1.32170168375632 2.12280368957514e-15 -0.568239705690126 0.00206510120463672 MirTarget;miRNATAP -0.168650734197616 6.85924013793372e-06 NA NA NA hsa-miR-330-3p TGFB2 0.432728362037032 0.00041335506960812 -0.568239705690126 0.00206510120463672 miRNATAP -0.169099911709115 0.00123359688318399 NA NA NA hsa-miR-330-5p TGFB2 0.626063225953928 3.42215028606779e-09 -0.568239705690126 0.00206510120463672 miRanda -0.231096330328837 9.82035598821339e-05 NA NA NA hsa-miR-331-5p TGFB2 0.682437632502949 4.10871642662371e-11 -0.568239705690126 0.00206510120463672 miRNATAP -0.256828592209254 2.39839780265118e-05 NA NA NA hsa-miR-375 TGFB2 2.09893673049766 1.68351780396203e-16 -0.568239705690126 0.00206510120463672 miRNAWalker2_validate -0.118032596246175 1.14664596099986e-06 NA NA NA hsa-miR-429 TGFB2 2.84108892259147 3.88520896426515e-64 -0.568239705690126 0.00206510120463672 miRNATAP -0.113931562701627 0.00112595441618086 NA NA NA hsa-miR-454-3p TGFB2 1.28177672191095 6.84024979484587e-21 -0.568239705690126 0.00206510120463672 MirTarget;miRNATAP -0.21652241903686 1.80168797038491e-06 NA NA NA hsa-miR-590-3p TGFB2 1.27438512890514 1.03164723481469e-23 -0.568239705690126 0.00206510120463672 mirMAP -0.218778123275247 1.55472558560304e-05 NA NA NA hsa-miR-590-5p TGFB2 0.746515607868274 8.51300479640125e-09 -0.568239705690126 0.00206510120463672 miRanda;miRNATAP -0.127583678067132 0.00859946694127918 NA NA NA hsa-let-7a-3p TGFB3 0.466622567891891 3.70886257943079e-07 0.82398957056453 1.83180841509129e-11 MirTarget -0.23002281448221 5.95409654478238e-07 NA NA NA hsa-let-7f-1-3p TGFB3 0.37532726250321 0.00156021688753682 0.82398957056453 1.83180841509129e-11 MirTarget -0.195594535331808 6.10557486170201e-08 NA NA NA hsa-miR-151a-5p TGFB3 0.509210376738198 3.17540030607215e-07 0.82398957056453 1.83180841509129e-11 MirTarget -0.460270915838936 5.41462985077644e-29 NA NA NA hsa-miR-26b-3p TGFB3 -0.62588114643887 3.30712936204727e-06 0.82398957056453 1.83180841509129e-11 MirTarget -0.166318643088715 1.09180542813277e-07 NA NA NA hsa-miR-29a-3p TGFB3 -0.699539666833076 1.13935003139957e-13 0.82398957056453 1.83180841509129e-11 miRNAWalker2_validate -0.215592947893623 1.26387377494944e-06 NA NA NA hsa-miR-29b-3p TGFB3 0.438847962603729 6.46722433236121e-05 0.82398957056453 1.83180841509129e-11 miRTarBase -0.300724044682202 2.93536952356929e-15 NA NA NA hsa-miR-511-5p TGFB3 -2.27545475897362 3.84085514050558e-36 0.82398957056453 1.83180841509129e-11 MirTarget -0.161630488068991 4.28099557548626e-13 NA NA NA hsa-miR-590-3p TGFB3 1.27438512890514 1.03164723481469e-23 0.82398957056453 1.83180841509129e-11 miRanda -0.276040958504426 1.7943368211393e-16 NA NA NA hsa-miR-629-3p TGFB3 1.25035919247365 3.91361135469024e-14 0.82398957056453 1.83180841509129e-11 MirTarget -0.184738491466436 9.18913270065683e-13 NA NA NA hsa-let-7a-5p TGFBR1 -0.210286642041636 0.0072546234707717 -0.276773756857041 0.00374479166499862 TargetScan;miRNATAP -0.135014125369019 0.00134477571196012 27234654 rs868 is contained in a let-7 miRNA binding site in the 3'UTR of TGFBR1 which might provide a functional basis for the association in MSS HNPCC colorectal cancer hsa-miR-101-3p TGFBR1 -0.126035286271986 0.145997832808138 -0.276773756857041 0.00374479166499862 miRNAWalker2_validate;miRNATAP -0.226110526180146 2.07174805788194e-09 NA NA NA hsa-miR-128-3p TGFBR1 0.90296715955238 9.925204823863e-23 -0.276773756857041 0.00374479166499862 miRNAWalker2_validate;miRTarBase -0.157338866756433 5.76850179866576e-06 NA NA NA hsa-miR-200b-3p TGFBR1 2.11744072703209 1.66710572104191e-43 -0.276773756857041 0.00374479166499862 mirMAP -0.133382190063293 2.90573705377005e-11 20498632 Inhibition of TGFbeta receptor 1 TGFBR1 in these cells induced MET and reduction of prometastatic miR-21 but caused an increase of the miR-200 family thyroid cancer hsa-miR-320a TGFBR1 -0.287921276129346 0.00141693637596294 -0.276773756857041 0.00374479166499862 PITA;miRanda;miRNATAP -0.136624380256683 0.000172858923508737 NA NA NA hsa-miR-338-3p TGFBR1 0.0799903526884966 0.575137668326679 -0.276773756857041 0.00374479166499862 miRanda -0.16505256729074 3.45773945956773e-13 NA NA NA hsa-miR-340-5p TGFBR1 1.0857159627596 4.94471062546756e-24 -0.276773756857041 0.00374479166499862 mirMAP -0.126480744659732 2.00427959104962e-05 NA NA NA hsa-miR-361-5p TGFBR1 -0.0996867547900457 0.095428250126326 -0.276773756857041 0.00374479166499862 miRanda;mirMAP;miRNATAP -0.343826208469508 4.82441885336511e-10 NA NA NA hsa-miR-429 TGFBR1 2.84108892259147 3.88520896426515e-64 -0.276773756857041 0.00374479166499862 miRanda;miRNATAP -0.101210444459427 1.79034747294782e-08 NA NA NA hsa-miR-98-5p TGFBR1 0.656336869298973 9.03113188590466e-15 -0.276773756857041 0.00374479166499862 miRNAWalker2_validate -0.153945603415794 5.62215521493057e-05 NA NA NA hsa-miR-106a-5p TGFBR2 0.574594373206545 0.000145868284001732 -2.39529308737339 4.9899056025782e-85 miRTarBase;miRNATAP -0.167004125374202 5.11178559030175e-08 22912877 MiR-106a inhibits the expression of transforming growth factor-β receptor 2 TGFBR2 leading to increased CRC cell migration and invasion cell migration colorectal cancer hsa-miR-106b-5p TGFBR2 1.22477789913175 2.31787213143326e-32 -2.39529308737339 4.9899056025782e-85 miRNATAP -0.583213497349775 2.44964235169299e-45 NA NA NA hsa-miR-107 TGFBR2 0.678998026350662 2.56224148930538e-16 -2.39529308737339 4.9899056025782e-85 miRanda;miRNATAP -0.530917906321599 1.66581882091816e-22 NA NA NA hsa-miR-130b-3p TGFBR2 1.38122163823846 1.00932179737836e-26 -2.39529308737339 4.9899056025782e-85 miRNAWalker2_validate;miRNATAP -0.355697993280506 3.73635681408915e-25 25024357 Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC lung squamous cell cancer hsa-miR-17-5p TGFBR2 0.599531757298529 1.07318660415906e-05 -2.39529308737339 4.9899056025782e-85 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.344837157501155 3.26279419912174e-25 25011053;27120811 We demonstrate that miR-17 overexpression interferes with the TGFβ-EMT axis and hinders RCC sphere formation; and validated TGFBR2 as a direct and biologically relevant target during this process;MiR-17-5p was found to bind to the 3'UTR of TGFBR2 mRNA and further validation of this specific binding was performed through a reporter assay; An inverse correlation between miR-17-5p and TGFBR2 protein was observed in gastric cancer tissues; Cell studies revealed that miR-17-5p negatively regulated TGFBR2 expression by directly binding to the 3'UTR of TGFBR2 mRNA thereby promoting cell growth and migration; The results of our study suggest a novel regulatory network in gastric cancer mediated by miR-17-5p and TGFBR2 and may indicate that TGFBR2 could serve as a new therapeutic target in gastric cancer ; kidney renal cell cancer;gastric cancer hsa-miR-18a-5p TGFBR2 0.969066793715868 1.69069796425892e-08 -2.39529308737339 4.9899056025782e-85 miRNAWalker2_validate -0.233316456798081 1.26332307500906e-18 NA NA NA hsa-miR-19a-3p TGFBR2 0.817507952171848 3.76285090469625e-08 -2.39529308737339 4.9899056025782e-85 miRNAWalker2_validate;miRNATAP -0.295433323573397 3.17340161137166e-22 NA NA NA hsa-miR-19b-3p TGFBR2 0.139124391010031 0.255658553872934 -2.39529308737339 4.9899056025782e-85 miRNAWalker2_validate;miRNATAP -0.23529469963531 5.83073772392392e-10 NA NA NA hsa-miR-20a-5p TGFBR2 0.44979911120222 0.000602386964327228 -2.39529308737339 4.9899056025782e-85 miRNAWalker2_validate;miRTarBase;miRNATAP -0.346418250547717 1.79003902635661e-23 NA NA NA hsa-miR-20b-5p TGFBR2 0.78236583455125 8.7938334801223e-05 -2.39529308737339 4.9899056025782e-85 miRNATAP -0.101055475114644 1.4278146071271e-05 NA NA NA hsa-miR-21-5p TGFBR2 2.32007501846389 3.08394781855554e-137 -2.39529308737339 4.9899056025782e-85 miRNAWalker2_validate;miRTarBase;miRNATAP -0.537594809270263 3.47307989185754e-40 24037531 Androgen receptor and microRNA 21 axis downregulates transforming growth factor beta receptor II TGFBR2 expression in prostate cancer; Our results revealed that miR-21 suppresses TGFBR2 levels by binding to its 3'-UTR and AR signaling further potentiates this effect in both untransformed and transformed human prostate epithelial cells as well as in human prostate cancers; Manipulation of androgen signaling or the expression levels of AR or miR-21 negatively altered TGFBR2 expression in untransformed and transformed human prostate epithelial cells human prostate cancer xenografts and mouse prostate glands; Together these results suggest that the AR and miR-21 axis exerts its oncogenic effects in prostate tumors by downregulating TGFBR2 hence inhibiting the tumor-suppressive activity of TGFβ pathway prostate cancer hsa-miR-301a-3p TGFBR2 1.32170168375632 2.12280368957514e-15 -2.39529308737339 4.9899056025782e-85 miRNATAP -0.317266296975964 1.73201531962553e-32 25551793 MicroRNA 301a promotes migration and invasion by targeting TGFBR2 in human colorectal cancer; TGFBR2 was identified to be the downstream target of miR-301a; Knockdown of TGFBR2 in cells treated by miR-301a inhibitor elevated the previously abrogated migration and invasion; Our data indicated that miR-301a correlated with the metastatic and invasive ability in human colorectal cancers and miR-301a exerted its role as oncogene by targeting TGFBR2 colorectal cancer hsa-miR-320b TGFBR2 0.412787504747938 0.00113457276903985 -2.39529308737339 4.9899056025782e-85 miRanda;miRNATAP -0.208017816637935 1.58734456312155e-08 NA NA NA hsa-miR-340-5p TGFBR2 1.0857159627596 4.94471062546756e-24 -2.39529308737339 4.9899056025782e-85 mirMAP -0.314168975517319 6.41119882395371e-14 NA NA NA hsa-miR-429 TGFBR2 2.84108892259147 3.88520896426515e-64 -2.39529308737339 4.9899056025782e-85 miRNATAP -0.404995702801572 1.14853648012577e-64 NA NA NA hsa-miR-454-3p TGFBR2 1.28177672191095 6.84024979484587e-21 -2.39529308737339 4.9899056025782e-85 miRNATAP -0.384614615164931 1.36686238358356e-32 NA NA NA hsa-miR-590-3p TGFBR2 1.27438512890514 1.03164723481469e-23 -2.39529308737339 4.9899056025782e-85 miRanda -0.338025545666787 3.04278770804611e-20 NA NA NA hsa-miR-590-5p TGFBR2 0.746515607868274 8.51300479640125e-09 -2.39529308737339 4.9899056025782e-85 miRNAWalker2_validate;miRTarBase;PITA;miRanda;miRNATAP -0.286652524899627 4.12566791851325e-16 NA NA NA hsa-miR-9-5p TGFBR2 0.734772328078424 0.00261982843636383 -2.39529308737339 4.9899056025782e-85 miRNATAP -0.11967052909348 2.52866655443074e-10 25024357 Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC lung squamous cell cancer hsa-miR-92a-3p TGFBR2 -0.342420481092807 0.000732275969501111 -2.39529308737339 4.9899056025782e-85 miRNAWalker2_validate -0.223515332507838 1.18491745689284e-06 NA NA NA hsa-miR-93-5p TGFBR2 1.01788600209314 1.24312921618126e-21 -2.39529308737339 4.9899056025782e-85 miRNAWalker2_validate;miRNATAP -0.609999323446729 8.30075605455623e-52 NA NA NA hsa-miR-146b-5p TRAF6 0.631041661167954 6.20366593452965e-08 -0.693006487455714 8.36029646109838e-25 miRNAWalker2_validate;MirTarget;PITA;miRanda;miRNATAP -0.147419231815741 1.69701717952743e-13 NA NA NA hsa-miR-15a-5p TRAF6 0.812445324157528 4.50263417099822e-20 -0.693006487455714 8.36029646109838e-25 MirTarget -0.281543879576705 2.4361850704736e-28 NA NA NA hsa-miR-340-5p TRAF6 1.0857159627596 4.94471062546756e-24 -0.693006487455714 8.36029646109838e-25 mirMAP -0.193902971481124 3.9737617749051e-20 NA NA NA hsa-miR-429 TRAF6 2.84108892259147 3.88520896426515e-64 -0.693006487455714 8.36029646109838e-25 miRanda -0.100224938591585 9.10568402232155e-15 NA NA NA hsa-miR-660-5p TRAF6 0.406910761707485 0.000156175371762464 -0.693006487455714 8.36029646109838e-25 MirTarget -0.203257926054558 4.25893866635695e-21 NA NA NA