miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-21-5p TET1 2.32007501846389 3.08394781855554e-137 -0.560839118524932 2.47023070053678e-06 miRNAWalker2_validate -0.219366694016521 3.08336716646783e-09 NA NA NA hsa-miR-29a-3p TET1 -0.699539666833076 1.13935003139957e-13 -0.560839118524932 2.47023070053678e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.121055322616723 0.00497623456890235 27555295;25367851;25616722 Furthermore data from bioinformatic analysis validated by dual-luciferase reporter gene assay showed that ten eleven translocation 1 TET1 was a direct target of miR-29a and over-expression of TET1 inhibited cell proliferation and migration which could be induced by the up-regulation of miR-29a; MiR-29a targets TET1 down regulates its expression and thus promotes EMT in breast cancer; Altogether we demonstrate that miR-29a acts as a tumor activator by targeting TET1 and induces cell proliferation and EMT in breast cancer;Negative feedback of miR 29 family TET1 involves in hepatocellular cancer; MiR-29b was proved to inhibit metastasis through the targeting of TET1 indicating that downregulation of miR-29 may involve in HCC carcinogenesis and progression through potentiation of TET1 expression;Erratum to: Negative feedback of miR 29 family TET1 involves in hepatocellular cancer; miR-29b was proved to inhibit metastasis through the targeting of TET1 indicating that downregulation of miR-29 may involve in HCC carcinogenesis and progression through potentiation of TET1 expression ;metastasis;progression;tumorigenesis;metastasis;progression;tumorigenesis breast cancer;liver cancer;liver cancer hsa-miR-29b-3p TET1 0.438847962603729 6.46722433236121e-05 -0.560839118524932 2.47023070053678e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.16104208480761 1.50396462937635e-05 25367851;25616722 Negative feedback of miR 29 family TET1 involves in hepatocellular cancer; MiR-29b was proved to inhibit metastasis through the targeting of TET1 indicating that downregulation of miR-29 may involve in HCC carcinogenesis and progression through potentiation of TET1 expression;Erratum to: Negative feedback of miR 29 family TET1 involves in hepatocellular cancer; miR-29b was proved to inhibit metastasis through the targeting of TET1 indicating that downregulation of miR-29 may involve in HCC carcinogenesis and progression through potentiation of TET1 expression metastasis;progression;tumorigenesis;metastasis;progression;tumorigenesis liver cancer;liver cancer hsa-miR-29c-3p TET1 -0.0652732378039769 0.563774115756922 -0.560839118524932 2.47023070053678e-06 MirTarget;miRNATAP -0.411917359075481 7.16963817256472e-32 NA NA NA hsa-miR-342-3p TET1 1.21944481975657 6.81914373001202e-19 -0.560839118524932 2.47023070053678e-06 miRanda -0.1159129829026 7.11329052918399e-05 NA NA NA hsa-miR-103a-3p TET2 0.610673390034345 1.63113920514646e-12 -0.357293733576945 3.41027192099165e-06 mirMAP -0.273473295415981 3.62416731194085e-20 NA NA NA hsa-miR-106b-5p TET2 1.22477789913175 2.31787213143326e-32 -0.357293733576945 3.41027192099165e-06 miRNATAP -0.13027326178245 1.11442929114585e-07 NA NA NA hsa-miR-107 TET2 0.678998026350662 2.56224148930538e-16 -0.357293733576945 3.41027192099165e-06 miRanda;mirMAP -0.206819897455082 3.6463002671312e-11 NA NA NA hsa-miR-146b-5p TET2 0.631041661167954 6.20366593452965e-08 -0.357293733576945 3.41027192099165e-06 miRanda -0.113714204080657 4.21073911874e-07 NA NA NA hsa-miR-181a-5p TET2 0.635863607630183 6.72486918157744e-11 -0.357293733576945 3.41027192099165e-06 MirTarget -0.106794212539232 7.31174277487782e-05 NA NA NA hsa-miR-20a-5p TET2 0.44979911120222 0.000602386964327228 -0.357293733576945 3.41027192099165e-06 miRNATAP -0.132886848210391 2.76466797966637e-11 NA NA NA hsa-miR-25-3p TET2 -0.00546790775985073 0.944061771389468 -0.357293733576945 3.41027192099165e-06 MirTarget -0.11724255654162 0.000624974703639989 NA NA NA hsa-miR-340-5p TET2 1.0857159627596 4.94471062546756e-24 -0.357293733576945 3.41027192099165e-06 mirMAP -0.127561811759648 9.47804856331414e-08 NA NA NA hsa-miR-361-5p TET2 -0.0996867547900457 0.095428250126326 -0.357293733576945 3.41027192099165e-06 miRanda;miRNATAP -0.283426265499888 2.14734084668446e-10 NA NA NA hsa-miR-589-5p TET2 0.367182541239722 1.67804815542873e-05 -0.357293733576945 3.41027192099165e-06 MirTarget -0.147452038672605 1.93445444469936e-06 NA NA NA hsa-miR-93-5p TET2 1.01788600209314 1.24312921618126e-21 -0.357293733576945 3.41027192099165e-06 miRNATAP -0.168170433572032 2.49349635176241e-12 NA NA NA hsa-let-7a-5p TET3 -0.210286642041636 0.0072546234707717 0.667896834715368 1.68552708580427e-14 TargetScan -0.134542203787478 0.000549915187020363 NA NA NA hsa-miR-139-5p TET3 -3.25846663863766 2.62018989415003e-112 0.667896834715368 1.68552708580427e-14 miRanda -0.156108284825354 2.08942379158764e-18 NA NA NA hsa-miR-140-3p TET3 -1.25844395244141 5.29222651039892e-33 0.667896834715368 1.68552708580427e-14 miRNATAP -0.196668429959442 7.21376110342369e-13 NA NA NA