miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7b-3p AKT2 0.239865279324672 0.00721479815526816 -0.340477996057433 3.62402949162022e-08 MirTarget -0.103250394013056 0.00819845290941259 NA NA NA hsa-miR-140-5p AKT2 0.504309496243674 3.09884038729031e-11 -0.340477996057433 3.62402949162022e-08 mirMAP -0.257894167615696 4.25294111137846e-09 NA NA NA hsa-miR-193a-3p AKT2 0.849206638484406 3.68101781083335e-14 -0.340477996057433 3.62402949162022e-08 miRanda -0.1602336102543 4.66296866332011e-08 NA NA NA hsa-miR-1976 AKT2 0.343475600930938 0.000360243844871748 -0.340477996057433 3.62402949162022e-08 miRNATAP -0.114100456416688 0.00148676672535644 NA NA NA hsa-miR-21-5p AKT2 2.51462371613332 3.30620591950316e-66 -0.340477996057433 3.62402949162022e-08 miRNAWalker2_validate -0.116002520060245 7.24256492760299e-10 NA NA NA hsa-miR-2355-5p AKT2 1.57515081110162 3.54962327490702e-48 -0.340477996057433 3.62402949162022e-08 mirMAP -0.158007486287123 5.63512797747714e-09 NA NA NA hsa-miR-24-3p AKT2 0.173813044685099 0.00565259443420961 -0.340477996057433 3.62402949162022e-08 mirMAP -0.145738275793208 0.0095430051404417 NA NA NA hsa-miR-330-5p AKT2 1.44960468659754 2.12131210588035e-45 -0.340477996057433 3.62402949162022e-08 miRanda -0.199850402161812 2.39463482226386e-12 NA NA NA hsa-miR-338-3p AKT2 0.906250377628867 2.76970900371139e-15 -0.340477996057433 3.62402949162022e-08 mirMAP -0.160942202850334 1.55482491354725e-08 NA NA NA hsa-miR-342-3p AKT2 1.4124432570595 1.07208971556131e-28 -0.340477996057433 3.62402949162022e-08 mirMAP -0.193694719446483 5.5338386148732e-16 NA NA NA hsa-miR-423-3p AKT2 0.460506077888547 3.44680149368459e-09 -0.340477996057433 3.62402949162022e-08 miRNAWalker2_validate -0.134093002116074 0.00224236224837297 NA NA NA hsa-miR-106b-5p AKT3 1.07509411417907 2.11739194181878e-36 -0.243988630870274 0.0117503955413685 miRNATAP -0.362551297020254 3.77551886386752e-11 NA NA NA hsa-miR-107 AKT3 0.140046250553248 0.0943611632552367 -0.243988630870274 0.0117503955413685 PITA;miRanda -0.284787420850406 8.53745778311515e-06 NA NA NA hsa-miR-146b-5p AKT3 1.40714170253819 2.9559871816487e-12 -0.243988630870274 0.0117503955413685 miRNAWalker2_validate -0.106480044558668 2.77668665683102e-05 NA NA NA hsa-miR-15a-5p AKT3 1.42663930007845 1.36006952074963e-57 -0.243988630870274 0.0117503955413685 miRNAWalker2_validate;miRTarBase;miRNATAP -0.209553352701426 2.74861510149098e-05 NA NA NA hsa-miR-15b-5p AKT3 0.773001494057531 1.71784656078957e-16 -0.243988630870274 0.0117503955413685 miRNATAP -0.179137071242714 0.00102312999530003 NA NA NA hsa-miR-16-5p AKT3 0.934012514027655 4.85417898318515e-24 -0.243988630870274 0.0117503955413685 miRNAWalker2_validate;miRTarBase;miRNATAP -0.174740148583929 0.00122158424330689 NA NA NA hsa-miR-17-3p AKT3 0.723795600017259 5.90151677164931e-18 -0.243988630870274 0.0117503955413685 miRNATAP -0.202376849787589 0.00088737719875351 NA NA NA hsa-miR-17-5p AKT3 0.494260110870015 3.8348005261e-09 -0.243988630870274 0.0117503955413685 TargetScan;miRNATAP -0.190824149294487 0.00237163147001594 NA NA NA hsa-miR-22-3p AKT3 0.198460552200729 0.00761005672059428 -0.243988630870274 0.0117503955413685 miRNATAP -0.407589872687642 1.12041867452881e-08 NA NA NA hsa-miR-29a-3p AKT3 -0.431613225927952 4.10166815070288e-08 -0.243988630870274 0.0117503955413685 miRNATAP -0.244491422189309 0.000269689815704259 NA NA NA hsa-miR-29b-3p AKT3 -0.228125979913806 0.0271621721891603 -0.243988630870274 0.0117503955413685 miRNATAP -0.247981734385757 1.40066355236384e-06 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-374b-5p AKT3 0.0804104684417872 0.365593963035077 -0.243988630870274 0.0117503955413685 mirMAP -0.250536892298211 3.33662467499594e-05 NA NA NA hsa-miR-421 AKT3 0.313155739887734 0.020433534776003 -0.243988630870274 0.0117503955413685 miRanda;mirMAP -0.144627984206661 0.000385343212972084 NA NA NA hsa-miR-542-3p AKT3 0.431147917094433 0.000254981247606435 -0.243988630870274 0.0117503955413685 miRanda -0.173551255334696 0.000111564350795738 NA NA NA hsa-miR-616-5p AKT3 0.913426384742148 3.78418389333709e-09 -0.243988630870274 0.0117503955413685 mirMAP -0.172749202880246 3.16635692442533e-07 NA NA NA hsa-miR-93-5p AKT3 1.37365940377595 2.37567548683245e-46 -0.243988630870274 0.0117503955413685 miRNATAP -0.172188027294336 0.000349761294454902 NA NA NA hsa-miR-361-3p ARRB1 1.08992546227594 1.13197240706704e-36 -0.321417777984933 0.000214269665514368 mirMAP -0.170559148667838 0.000661130052536384 NA NA NA hsa-miR-671-5p ARRB1 0.740296481994777 8.07053661008188e-07 -0.321417777984933 0.000214269665514368 MirTarget -0.131627473100232 3.41916562577045e-05 NA NA NA hsa-miR-125a-3p ARRB2 -0.372794471295036 0.000941729459601642 1.4017498012267 7.10108188101651e-55 miRanda -0.166622129531045 0.00139113510689173 NA NA NA hsa-miR-149-5p ARRB2 -1.95790336710741 8.46371715052367e-27 1.4017498012267 7.10108188101651e-55 miRNAWalker2_validate -0.222077489330306 6.83030441207317e-15 NA NA NA hsa-miR-199a-5p ARRB2 -1.64658415208633 1.01615659358973e-23 1.4017498012267 7.10108188101651e-55 MirTarget;miRanda -0.20829471914368 1.52906179663968e-10 NA NA NA hsa-miR-615-3p ARRB2 -0.777370544471479 2.08193713560545e-08 1.4017498012267 7.10108188101651e-55 miRNAWalker2_validate -0.121226149160178 0.00354621666132195 NA NA NA hsa-let-7a-3p ATF2 0.0677487960013088 0.460458477653989 -0.430671917958647 1.95972009533608e-05 MirTarget;mirMAP;miRNATAP -0.258206576796938 2.61705263820418e-05 NA NA NA hsa-let-7f-1-3p ATF2 0.477913872379336 4.46669616865068e-05 -0.430671917958647 1.95972009533608e-05 MirTarget;mirMAP -0.17834629067546 0.000534605693773569 NA NA NA hsa-miR-140-3p ATF2 0.989350547007025 6.14964028267239e-25 -0.430671917958647 1.95972009533608e-05 MirTarget;PITA;miRNATAP -0.164416457351873 0.00257839953228269 NA NA NA hsa-miR-15a-5p ATF2 1.42663930007845 1.36006952074963e-57 -0.430671917958647 1.95972009533608e-05 miRNAWalker2_validate -0.233760076403299 8.31704154782812e-06 NA NA NA hsa-miR-181a-5p ATF2 1.11111114875339 3.97880443756442e-29 -0.430671917958647 1.95972009533608e-05 mirMAP;miRNATAP -0.177371113322549 0.00063116587052713 NA NA NA hsa-miR-181b-5p ATF2 1.49054296272357 3.69051660739368e-41 -0.430671917958647 1.95972009533608e-05 mirMAP;miRNATAP -0.187569275587416 2.3264034331938e-05 NA NA NA hsa-miR-19b-3p ATF2 0.195940928879427 0.0300512922542325 -0.430671917958647 1.95972009533608e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.171622349992384 0.0062154989166173 NA NA NA hsa-miR-21-5p ATF2 2.51462371613332 3.30620591950316e-66 -0.430671917958647 1.95972009533608e-05 miRNAWalker2_validate -0.146377158546288 2.19887514179696e-06 NA NA NA hsa-miR-221-3p ATF2 0.337895669520713 0.0136448974691037 -0.430671917958647 1.95972009533608e-05 MirTarget -0.20430513138651 4.43575326168723e-07 NA NA NA hsa-miR-590-3p ATF2 1.13702599385212 3.53435739887793e-22 -0.430671917958647 1.95972009533608e-05 MirTarget;miRanda;mirMAP;miRNATAP -0.133368731251531 0.00299498751306343 NA NA NA hsa-miR-182-5p BDNF -0.608710746044567 0.0025264935278104 1.32053589639348 4.6461489093674e-09 MirTarget;miRNATAP -0.320911985212199 2.19358929074297e-07 NA NA NA hsa-miR-22-3p BDNF 0.198460552200729 0.00761005672059428 1.32053589639348 4.6461489093674e-09 miRNAWalker2_validate;miRTarBase -0.934418001650865 4.10404904290013e-08 NA NA NA hsa-miR-3065-3p BDNF -1.64500070417457 9.57561660036697e-16 1.32053589639348 4.6461489093674e-09 MirTarget;miRNATAP -0.173566329974244 0.00341422805602149 NA NA NA hsa-miR-30b-5p BDNF -1.18330589477119 6.8341618466966e-27 1.32053589639348 4.6461489093674e-09 miRNATAP -0.418679389730946 7.95864809848167e-05 NA NA NA hsa-miR-361-5p BDNF 0.0514169367202078 0.382929376393199 1.32053589639348 4.6461489093674e-09 PITA;miRanda;miRNATAP -0.579854997171823 0.00910447765702249 NA NA NA hsa-miR-3913-5p BDNF 0.136365354811444 0.24239516424369 1.32053589639348 4.6461489093674e-09 mirMAP -0.437476166734317 0.000137119405950826 NA NA NA hsa-miR-508-3p BDNF -3.41433288024917 3.47699261121175e-37 1.32053589639348 4.6461489093674e-09 PITA;miRNATAP -0.227379255506386 4.7723104940365e-08 NA NA NA hsa-miR-590-3p BRAF 1.13702599385212 3.53435739887793e-22 -0.358904733193809 0.000122580700403634 miRanda -0.12838824199161 0.00196280318625335 NA NA NA hsa-miR-188-5p CACNA1A -1.74586655806628 1.50431624674552e-28 0.765173433777082 1.54483969006519e-07 PITA -0.232111448061469 1.77324788361642e-06 NA NA NA hsa-miR-29b-2-5p CACNA1A -0.297854154636098 0.00260919277325581 0.765173433777082 1.54483969006519e-07 mirMAP -0.302170254841727 0.000255281986620536 NA NA NA hsa-miR-107 CACNA1C 0.140046250553248 0.0943611632552367 0.716850944863711 3.05841004806482e-06 miRNATAP -0.280232736753656 0.00695579078322016 NA NA NA hsa-miR-148b-5p CACNA1C 0.269550343699955 0.0383631776794927 0.716850944863711 3.05841004806482e-06 mirMAP -0.19888484559664 0.00353729941656481 NA NA NA hsa-miR-1976 CACNA1C 0.343475600930938 0.000360243844871748 0.716850944863711 3.05841004806482e-06 MirTarget -0.30623921542157 0.000577285938624593 NA NA NA hsa-miR-200b-3p CACNA1C -1.70383252137161 2.38979336321755e-30 0.716850944863711 3.05841004806482e-06 MirTarget;TargetScan -0.237632500916391 4.98563698264238e-06 NA NA NA hsa-miR-200c-3p CACNA1C -5.40303134829523 2.74173143360645e-94 0.716850944863711 3.05841004806482e-06 MirTarget -0.10962437576971 6.5015914856615e-06 NA NA NA hsa-miR-29a-3p CACNA1C -0.431613225927952 4.10166815070288e-08 0.716850944863711 3.05841004806482e-06 MirTarget -0.61299042815903 7.9381492619946e-09 NA NA NA hsa-miR-29b-3p CACNA1C -0.228125979913806 0.0271621721891603 0.716850944863711 3.05841004806482e-06 MirTarget -0.66278359984523 1.00373331576026e-16 NA NA NA hsa-miR-29c-3p CACNA1C -0.238671318446745 0.0141475322347596 0.716850944863711 3.05841004806482e-06 MirTarget -0.363671533379846 3.69082792482162e-05 NA NA NA hsa-miR-30a-5p CACNA1C -0.778411951775343 2.73322451127932e-16 0.716850944863711 3.05841004806482e-06 mirMAP -0.31739825851008 0.000236422721069026 NA NA NA hsa-miR-30b-5p CACNA1C -1.18330589477119 6.8341618466966e-27 0.716850944863711 3.05841004806482e-06 mirMAP -0.225243678379244 0.00173674933747375 NA NA NA hsa-miR-30c-5p CACNA1C -1.08783070774238 2.02505402525786e-24 0.716850944863711 3.05841004806482e-06 mirMAP -0.314876393162764 2.36816794847842e-05 NA NA NA hsa-miR-30e-5p CACNA1C -0.0905907245198101 0.21196704484334 0.716850944863711 3.05841004806482e-06 mirMAP -0.812090244216083 3.49865000084847e-12 NA NA NA hsa-miR-33a-5p CACNA1C -1.59840463890997 1.13487952314403e-18 0.716850944863711 3.05841004806482e-06 MirTarget -0.13376384917816 0.00297303215485129 NA NA NA hsa-miR-429 CACNA1C -2.16569233119434 2.66862243626443e-37 0.716850944863711 3.05841004806482e-06 MirTarget;PITA;miRanda;miRNATAP -0.180094102775902 5.71733551155507e-05 NA NA NA hsa-miR-532-5p CACNA1C -1.09700348358668 8.34836230254408e-26 0.716850944863711 3.05841004806482e-06 PITA -0.540285293106209 2.32345097195692e-13 NA NA NA hsa-miR-577 CACNA1C -1.48881999472397 7.03080165111147e-10 0.716850944863711 3.05841004806482e-06 PITA -0.1594221667964 3.66304212129454e-06 NA NA NA hsa-miR-589-3p CACNA1C -0.0184909376114044 0.903149951095234 0.716850944863711 3.05841004806482e-06 MirTarget;mirMAP -0.250658186560042 1.22899180400175e-05 NA NA NA hsa-miR-660-5p CACNA1C -1.20833564582661 8.48975910642834e-23 0.716850944863711 3.05841004806482e-06 MirTarget -0.368988445002518 8.64448263155945e-09 NA NA NA hsa-miR-671-3p CACNA1C -0.118856749340912 0.414450889866758 0.716850944863711 3.05841004806482e-06 miRNATAP -0.271968034983322 9.33887263620692e-06 NA NA NA hsa-miR-96-5p CACNA1C -1.00223771166604 3.91564621567028e-06 0.716850944863711 3.05841004806482e-06 MirTarget;TargetScan -0.210179857115136 1.11805539082502e-07 NA NA NA hsa-let-7i-5p CACNA1D 0.911372377723717 7.11483853341932e-31 -0.612508745037678 0.000684781886249508 miRNATAP -0.61354571397065 8.75500481556573e-08 NA NA NA hsa-miR-134-5p CACNA1D -0.940639322366899 1.24417590236773e-06 -0.612508745037678 0.000684781886249508 MirTarget -0.141493630329194 0.00543088872571502 NA NA NA hsa-miR-142-3p CACNA1D 1.88928758773299 2.72985643829893e-22 -0.612508745037678 0.000684781886249508 miRanda -0.224238417067122 2.3769949559846e-06 NA NA NA hsa-miR-150-5p CACNA1D 1.00371863159681 1.09871676395528e-09 -0.612508745037678 0.000684781886249508 MirTarget -0.234453233911558 6.90068794382855e-05 NA NA NA hsa-miR-326 CACNA1D 0.0283498662828876 0.83943976716391 -0.612508745037678 0.000684781886249508 miRanda -0.288801958926891 5.23021888591791e-05 NA NA NA hsa-miR-330-5p CACNA1D 1.44960468659754 2.12131210588035e-45 -0.612508745037678 0.000684781886249508 miRanda -0.442354469227209 1.2905780961971e-07 NA NA NA hsa-miR-342-3p CACNA1D 1.4124432570595 1.07208971556131e-28 -0.612508745037678 0.000684781886249508 miRanda -0.360673112049026 4.17275782409971e-07 NA NA NA hsa-miR-590-3p CACNA1D 1.13702599385212 3.53435739887793e-22 -0.612508745037678 0.000684781886249508 miRanda;miRNATAP -0.249190385659037 0.00184092638514649 NA NA NA hsa-miR-625-5p CACNA1D 0.153090549230629 0.330314026509869 -0.612508745037678 0.000684781886249508 MirTarget -0.232356143132043 0.000754920170573321 NA NA NA hsa-miR-629-5p CACNA1D 1.73389921851483 5.39614356468007e-48 -0.612508745037678 0.000684781886249508 MirTarget -0.302683296055868 2.57557910327263e-05 NA NA NA hsa-miR-141-3p CACNA1E -5.87110686537457 1.20877726722907e-85 0.398553815240906 0.0688348888728027 MirTarget;TargetScan;miRNATAP -0.139092782101113 6.31769156456469e-06 NA NA NA hsa-miR-375 CACNA1E -1.46468479447701 9.20596529469647e-07 0.398553815240906 0.0688348888728027 miRNATAP -0.15405367792066 9.825193694845e-05 NA NA NA hsa-miR-675-3p CACNA1E -2.3194779574848 3.36664460213368e-15 0.398553815240906 0.0688348888728027 mirMAP -0.155684324736379 7.02355449601718e-05 NA NA NA hsa-miR-96-5p CACNA1E -1.00223771166604 3.91564621567028e-06 0.398553815240906 0.0688348888728027 miRNATAP -0.155065286083701 0.00615668230092236 NA NA NA hsa-miR-32-5p CACNA1H 0.407826130035097 7.26884631998646e-06 -0.801360361084313 8.07455409380397e-07 miRNATAP -0.305729739293204 0.00213819387245507 NA NA NA hsa-miR-361-3p CACNA1H 1.08992546227594 1.13197240706704e-36 -0.801360361084313 8.07455409380397e-07 MirTarget;mirMAP -0.516926510836097 3.0002489672911e-08 NA NA NA hsa-miR-1271-5p CACNA2D2 0.900599702972936 3.07963385418853e-10 -2.97359586958262 9.62523438304323e-72 MirTarget -0.437675165557803 1.07492270942983e-08 NA NA NA hsa-miR-142-3p CACNA2D2 1.88928758773299 2.72985643829893e-22 -2.97359586958262 9.62523438304323e-72 miRanda -0.531379046024787 1.90882749546785e-25 NA NA NA hsa-miR-181a-5p CACNA2D2 1.11111114875339 3.97880443756442e-29 -2.97359586958262 9.62523438304323e-72 miRNATAP -0.936238517260206 7.06072352830771e-21 NA NA NA hsa-miR-181b-5p CACNA2D2 1.49054296272357 3.69051660739368e-41 -2.97359586958262 9.62523438304323e-72 miRNATAP -0.968241953867094 1.20904563694696e-31 NA NA NA hsa-miR-181c-5p CACNA2D2 0.762784646696248 4.48373118147729e-10 -2.97359586958262 9.62523438304323e-72 miRNATAP -0.304417587764172 0.000846016053905618 NA NA NA hsa-miR-193a-3p CACNA2D2 0.849206638484406 3.68101781083335e-14 -2.97359586958262 9.62523438304323e-72 miRanda -0.82170227815144 1.69436857052727e-18 NA NA NA hsa-miR-34a-5p CACNA2D2 1.07544567720768 1.81510842038009e-20 -2.97359586958262 9.62523438304323e-72 mirMAP -0.737742460040271 1.11756609739078e-16 NA NA NA hsa-miR-361-3p CACNA2D2 1.08992546227594 1.13197240706704e-36 -2.97359586958262 9.62523438304323e-72 MirTarget;PITA -1.29626344763609 3.24042597537265e-33 NA NA NA hsa-miR-423-5p CACNA2D2 0.250929012519631 0.00288495915028486 -2.97359586958262 9.62523438304323e-72 MirTarget;miRNATAP -0.529333845838783 0.000100994907654968 NA NA NA hsa-miR-590-3p CACNA2D2 1.13702599385212 3.53435739887793e-22 -2.97359586958262 9.62523438304323e-72 miRanda -0.827060210597833 6.77602405351639e-22 NA NA NA hsa-miR-193a-3p CACNA2D3 0.849206638484406 3.68101781083335e-14 -2.53002802123335 4.00725378236199e-41 miRanda -0.469155679464593 3.26493173322158e-06 NA NA NA hsa-miR-27a-3p CACNA2D3 0.558934437526245 1.44256383086177e-12 -2.53002802123335 4.00725378236199e-41 miRNATAP -0.659121586803351 5.42667766337126e-06 NA NA NA hsa-miR-28-5p CACNA2D3 0.461962042257226 3.32424690573327e-11 -2.53002802123335 4.00725378236199e-41 miRanda -0.722404065700237 1.34547781930939e-05 NA NA NA hsa-miR-590-3p CACNA2D3 1.13702599385212 3.53435739887793e-22 -2.53002802123335 4.00725378236199e-41 miRanda -0.578346837283348 3.9189851866749e-10 NA NA NA hsa-miR-335-5p CACNA2D4 -2.09515619961552 1.03765771499548e-25 1.51494222377785 5.78563668595922e-21 miRNAWalker2_validate -0.143184535800304 0.00118316807632756 NA NA NA hsa-miR-429 CACNA2D4 -2.16569233119434 2.66862243626443e-37 1.51494222377785 5.78563668595922e-21 miRanda -0.359425877453158 6.23386496416801e-14 NA NA NA hsa-miR-125a-5p CACNB1 -0.561874059994802 7.3931856356891e-13 0.995347113549349 2.70953748485674e-12 PITA;mirMAP;miRNATAP -0.28856733774665 0.00435266077610807 NA NA NA hsa-miR-125b-5p CACNB1 -0.825456421494266 2.13029877878434e-15 0.995347113549349 2.70953748485674e-12 mirMAP;miRNATAP -0.212256394253824 0.00468454512355501 NA NA NA hsa-miR-424-5p CACNB1 0.0100536033936258 0.949562147664211 0.995347113549349 2.70953748485674e-12 miRNATAP -0.149624591183141 0.00351110762587933 NA NA NA hsa-miR-429 CACNB1 -2.16569233119434 2.66862243626443e-37 0.995347113549349 2.70953748485674e-12 miRNATAP -0.204608087494493 1.16448804278534e-06 NA NA NA hsa-miR-500a-3p CACNB1 -1.41379327701944 2.73403824528455e-37 0.995347113549349 2.70953748485674e-12 miRNATAP -0.467247066182085 1.42937016850302e-13 NA NA NA hsa-miR-146b-3p CACNB2 1.20941495066078 2.12939149602665e-10 -0.0157801958018999 0.916697571102891 miRNATAP -0.22282097658098 9.03766101306947e-08 NA NA NA hsa-miR-182-5p CACNB2 -0.608710746044567 0.0025264935278104 -0.0157801958018999 0.916697571102891 miRNATAP -0.162885682813514 6.27610252496678e-05 NA NA NA hsa-miR-23a-3p CACNB2 0.761438723382355 4.09310879199257e-27 -0.0157801958018999 0.916697571102891 mirMAP -0.29543177121248 0.00706073398638458 NA NA NA hsa-miR-27a-3p CACNB2 0.558934437526245 1.44256383086177e-12 -0.0157801958018999 0.916697571102891 MirTarget;miRNATAP -0.278311103738221 0.00673447579857714 NA NA NA hsa-miR-29a-5p CACNB2 -0.519003718107105 1.03351148282116e-06 -0.0157801958018999 0.916697571102891 MirTarget -0.343180941454985 7.4272997865774e-06 NA NA NA hsa-miR-339-5p CACNB2 0.322848334531193 0.0117281778821612 -0.0157801958018999 0.916697571102891 miRNATAP -0.224846843641979 0.000499471585175419 NA NA NA hsa-miR-550a-3p CACNB2 1.11969632674498 4.64306608686e-12 -0.0157801958018999 0.916697571102891 MirTarget;miRNATAP -0.178230774279166 0.000903057059603279 NA NA NA hsa-miR-7-1-3p CACNB2 0.544601828025304 5.33830451326047e-07 -0.0157801958018999 0.916697571102891 mirMAP -0.226685301328774 0.00265805916873897 NA NA NA hsa-miR-96-5p CACNB2 -1.00223771166604 3.91564621567028e-06 -0.0157801958018999 0.916697571102891 miRNATAP -0.146166640702022 0.00015677815074989 NA NA NA hsa-miR-107 CACNB3 0.140046250553248 0.0943611632552367 0.346860498976578 0.000772774501205287 miRanda -0.269350176655345 8.76307379745337e-05 NA NA NA hsa-let-7a-5p CACNB4 0.0791334022258656 0.422980622613373 -2.31766445730623 3.718552097769e-34 TargetScan;miRNATAP -0.372783609072149 0.00175588731476672 NA NA NA hsa-let-7b-5p CACNB4 0.770868211539597 6.63408323707647e-21 -2.31766445730623 3.718552097769e-34 miRNATAP -1.04941159942161 3.92631192501053e-16 NA NA NA hsa-let-7d-5p CACNB4 -0.0696879530236796 0.333110939877203 -2.31766445730623 3.718552097769e-34 miRNATAP -0.436862999638193 0.00820391711045954 NA NA NA hsa-let-7i-5p CACNB4 0.911372377723717 7.11483853341932e-31 -2.31766445730623 3.718552097769e-34 miRNATAP -1.04632159239663 9.15115406078617e-16 NA NA NA hsa-miR-126-5p CACNB4 0.785607261431085 5.77058629454465e-13 -2.31766445730623 3.718552097769e-34 mirMAP -0.675224855289651 2.17378480532724e-11 NA NA NA hsa-miR-132-3p CACNB4 0.291409674711894 0.000912684337101876 -2.31766445730623 3.718552097769e-34 miRNATAP -0.586224793769825 9.22002465891536e-06 NA NA NA hsa-miR-142-5p CACNB4 1.88417391525707 1.2096808039882e-27 -2.31766445730623 3.718552097769e-34 mirMAP -0.344917938005076 1.44964877904195e-08 NA NA NA hsa-miR-146b-5p CACNB4 1.40714170253819 2.9559871816487e-12 -2.31766445730623 3.718552097769e-34 miRanda -0.209133634945668 0.000172089122293941 NA NA NA hsa-miR-155-5p CACNB4 3.26274490570809 5.06841441826518e-51 -2.31766445730623 3.718552097769e-34 mirMAP;miRNATAP -0.374557225450471 7.81788552879236e-18 NA NA NA hsa-miR-15a-5p CACNB4 1.42663930007845 1.36006952074963e-57 -2.31766445730623 3.718552097769e-34 miRNATAP -0.827291913413097 4.85208206579699e-15 NA NA NA hsa-miR-15b-3p CACNB4 1.49422666971434 5.44139893275088e-29 -2.31766445730623 3.718552097769e-34 mirMAP -0.464193129137105 3.30243850152448e-09 NA NA NA hsa-miR-15b-5p CACNB4 0.773001494057531 1.71784656078957e-16 -2.31766445730623 3.718552097769e-34 miRNATAP -0.687790852253177 4.21317474013148e-09 NA NA NA hsa-miR-16-1-3p CACNB4 1.51429140700091 3.17219833254498e-37 -2.31766445730623 3.718552097769e-34 mirMAP -0.565331870069973 7.33338290673347e-11 NA NA NA hsa-miR-16-5p CACNB4 0.934012514027655 4.85417898318515e-24 -2.31766445730623 3.718552097769e-34 miRNATAP -0.701108107664724 1.38226155643089e-09 NA NA NA hsa-miR-181a-5p CACNB4 1.11111114875339 3.97880443756442e-29 -2.31766445730623 3.718552097769e-34 mirMAP -0.821907177230157 2.3625371873217e-15 NA NA NA hsa-miR-181b-5p CACNB4 1.49054296272357 3.69051660739368e-41 -2.31766445730623 3.718552097769e-34 mirMAP -0.795687294332981 1.26391598420082e-19 NA NA NA hsa-miR-181c-5p CACNB4 0.762784646696248 4.48373118147729e-10 -2.31766445730623 3.718552097769e-34 mirMAP -0.431530603891958 2.89542941620943e-06 NA NA NA hsa-miR-196a-5p CACNB4 0.440858887700369 2.0077143292463e-05 -2.31766445730623 3.718552097769e-34 miRNATAP -0.692134053662827 2.74107323513441e-10 NA NA NA hsa-miR-196b-5p CACNB4 0.476515361561837 0.0161581243061122 -2.31766445730623 3.718552097769e-34 miRNATAP -0.22952565014504 8.62894870604737e-05 NA NA NA hsa-miR-20a-3p CACNB4 -0.112128426252791 0.346272219285942 -2.31766445730623 3.718552097769e-34 miRNATAP -0.325835541277928 0.000930633132790061 NA NA NA hsa-miR-223-5p CACNB4 0.929436407668104 3.15737560243324e-06 -2.31766445730623 3.718552097769e-34 mirMAP -0.163012968223126 0.00804863559361853 NA NA NA hsa-miR-25-3p CACNB4 1.12016166564779 3.79069348635778e-48 -2.31766445730623 3.718552097769e-34 mirMAP -1.11721776444596 3.94549279408017e-19 NA NA NA hsa-miR-32-5p CACNB4 0.407826130035097 7.26884631998646e-06 -2.31766445730623 3.718552097769e-34 mirMAP -0.41593844443147 0.00111983698070914 NA NA NA hsa-miR-320a CACNB4 0.412740558379182 2.02929519701706e-05 -2.31766445730623 3.718552097769e-34 PITA;miRanda -0.770257760357813 4.39162904771422e-11 NA NA NA hsa-miR-320b CACNB4 0.300497419754843 0.0245219177384172 -2.31766445730623 3.718552097769e-34 PITA;miRanda -0.432284895029318 5.53841802717516e-07 NA NA NA hsa-miR-330-3p CACNB4 0.912906550436308 3.35037014057665e-13 -2.31766445730623 3.718552097769e-34 mirMAP -0.489181889155113 6.32218877246713e-08 NA NA NA hsa-miR-338-3p CACNB4 0.906250377628867 2.76970900371139e-15 -2.31766445730623 3.718552097769e-34 PITA;miRanda;miRNATAP -0.479993918486573 6.58502608458311e-07 NA NA NA hsa-miR-338-5p CACNB4 0.628429807914222 1.27575140717947e-06 -2.31766445730623 3.718552097769e-34 mirMAP;miRNATAP -0.337089367997208 0.000183961745848056 NA NA NA hsa-miR-340-5p CACNB4 1.14479851941741 2.91936881701444e-15 -2.31766445730623 3.718552097769e-34 mirMAP -0.422848538586796 2.40483399042587e-08 NA NA NA hsa-miR-342-3p CACNB4 1.4124432570595 1.07208971556131e-28 -2.31766445730623 3.718552097769e-34 miRanda -0.516710869376405 3.36119974295574e-10 NA NA NA hsa-miR-374a-5p CACNB4 0.543061152108237 2.19403097299769e-14 -2.31766445730623 3.718552097769e-34 mirMAP -0.652127434304935 4.0717289214466e-05 NA NA NA hsa-miR-450b-5p CACNB4 0.404819502355575 0.00357671373841274 -2.31766445730623 3.718552097769e-34 miRNATAP -0.251888724322496 0.0026478883720068 NA NA NA hsa-miR-455-5p CACNB4 0.773674551205946 2.12957541541474e-09 -2.31766445730623 3.718552097769e-34 PITA;miRanda;miRNATAP -0.562226456791854 6.56408078353327e-11 NA NA NA hsa-miR-550a-3p CACNB4 1.11969632674498 4.64306608686e-12 -2.31766445730623 3.718552097769e-34 miRNATAP -0.259616521456787 0.000588069584433098 NA NA NA hsa-miR-590-3p CACNB4 1.13702599385212 3.53435739887793e-22 -2.31766445730623 3.718552097769e-34 miRanda;mirMAP;miRNATAP -0.433194565445131 2.79153075918271e-06 NA NA NA hsa-miR-92b-3p CACNB4 0.418630595140165 6.50466149211154e-05 -2.31766445730623 3.718552097769e-34 mirMAP -0.457246842411354 3.32688362057307e-05 NA NA NA hsa-let-7b-3p CACNG4 0.239865279324672 0.00721479815526816 -2.72392143749873 1.25557988574743e-18 MirTarget -0.74458996440698 0.000235519249504359 NA NA NA hsa-let-7f-1-3p CACNG4 0.477913872379336 4.46669616865068e-05 -2.72392143749873 1.25557988574743e-18 MirTarget -0.439074005363371 0.0081726455889241 NA NA NA hsa-let-7i-5p CACNG4 0.911372377723717 7.11483853341932e-31 -2.72392143749873 1.25557988574743e-18 miRNATAP -0.888364061328499 1.99857534291344e-05 NA NA NA hsa-miR-185-3p CACNG4 0.993379985307475 2.62011454953707e-13 -2.72392143749873 1.25557988574743e-18 mirMAP -0.711607186493302 2.5217623766325e-08 NA NA NA hsa-miR-186-5p CACNG4 0.507217561043443 9.04455748270995e-10 -2.72392143749873 1.25557988574743e-18 mirMAP -0.95422717350016 7.16952120660144e-06 NA NA NA hsa-miR-28-5p CACNG4 0.461962042257226 3.32424690573327e-11 -2.72392143749873 1.25557988574743e-18 miRanda -1.2791499624601 3.77796007410279e-07 NA NA NA hsa-miR-3127-5p CACNG4 0.952801473575318 5.81162987769266e-14 -2.72392143749873 1.25557988574743e-18 mirMAP -0.634619816520635 7.05440612276976e-06 NA NA NA hsa-miR-330-3p CACNG4 0.912906550436308 3.35037014057665e-13 -2.72392143749873 1.25557988574743e-18 mirMAP -0.49905769512148 0.000420899041978955 NA NA NA hsa-miR-590-3p CACNG4 1.13702599385212 3.53435739887793e-22 -2.72392143749873 1.25557988574743e-18 miRanda -0.592397576541091 3.59227725004413e-05 NA NA NA hsa-miR-616-5p CACNG4 0.913426384742148 3.78418389333709e-09 -2.72392143749873 1.25557988574743e-18 MirTarget;miRNATAP -0.584063150979398 3.03566262619089e-07 NA NA NA hsa-let-7c-5p CASP3 -0.293028324454433 0.00593011890352725 0.624242394440305 5.90002612682267e-19 MirTarget -0.150491988361227 8.20207927774945e-05 NA NA NA hsa-miR-139-5p CASP3 -0.704802495091118 2.36904108453776e-06 0.624242394440305 5.90002612682267e-19 miRanda -0.150517905192826 1.32408198037557e-08 NA NA NA hsa-miR-26b-5p CASP3 -0.251437253429904 0.00270935785098697 0.624242394440305 5.90002612682267e-19 miRNAWalker2_validate -0.127148355034747 0.00957021650716659 NA NA NA hsa-miR-30a-5p CASP3 -0.778411951775343 2.73322451127932e-16 0.624242394440305 5.90002612682267e-19 miRNATAP -0.345510630044846 9.70443157697282e-19 NA NA NA hsa-miR-30c-5p CASP3 -1.08783070774238 2.02505402525786e-24 0.624242394440305 5.90002612682267e-19 miRNATAP -0.225556550786425 8.74333982362343e-11 NA NA NA hsa-miR-30d-5p CASP3 -0.202727675788184 0.00659067084745794 0.624242394440305 5.90002612682267e-19 miRNAWalker2_validate;miRTarBase;miRNATAP -0.283929971801396 1.94904159154662e-07 NA NA NA hsa-miR-335-5p CD14 -2.09515619961552 1.03765771499548e-25 1.64098597710522 1.54362557798196e-27 miRNAWalker2_validate -0.120577681727453 0.0043688079040422 NA NA NA hsa-miR-204-5p CDC25B -1.67490789640238 9.14741888352476e-10 0.69512214216171 4.96228149795194e-11 miRNATAP -0.141516835038019 8.81206120698199e-12 NA NA NA hsa-miR-27b-3p CDC25B -0.699527231242518 1.07356023759234e-15 0.69512214216171 4.96228149795194e-11 miRNATAP -0.411464600584344 2.04191764957766e-10 NA NA NA hsa-miR-429 CDC25B -2.16569233119434 2.66862243626443e-37 0.69512214216171 4.96228149795194e-11 miRanda -0.22133165644704 3.48889283387863e-13 NA NA NA hsa-miR-106b-5p CHP2 1.07509411417907 2.11739194181878e-36 -4.85824590499015 3.05626798767572e-58 MirTarget -1.58995368270032 4.17510489844563e-15 NA NA NA hsa-miR-17-5p CHP2 0.494260110870015 3.8348005261e-09 -4.85824590499015 3.05626798767572e-58 MirTarget -1.05293982395628 6.26552263101198e-06 NA NA NA hsa-miR-20a-5p CHP2 0.702602695798242 4.06372887613329e-13 -4.85824590499015 3.05626798767572e-58 MirTarget -1.26631554399921 8.83278262712219e-11 NA NA NA hsa-miR-224-5p CHP2 2.84654230414912 3.0480927226395e-47 -4.85824590499015 3.05626798767572e-58 MirTarget -0.806037485399145 6.26769397013649e-23 NA NA NA hsa-miR-320a CHP2 0.412740558379182 2.02929519701706e-05 -4.85824590499015 3.05626798767572e-58 miRanda -0.731704395825421 0.000358100930886103 NA NA NA hsa-miR-93-5p CHP2 1.37365940377595 2.37567548683245e-46 -4.85824590499015 3.05626798767572e-58 MirTarget -1.74045083301575 3.782182814463e-25 NA NA NA hsa-miR-126-5p CHUK 0.785607261431085 5.77058629454465e-13 -0.85746072421144 8.10744991906236e-38 MirTarget;mirMAP;miRNATAP -0.141478846302423 0.000105653732136013 NA NA NA hsa-miR-15a-5p CHUK 1.42663930007845 1.36006952074963e-57 -0.85746072421144 8.10744991906236e-38 miRNAWalker2_validate;miRTarBase;MirTarget -0.318418636879753 7.69752994687939e-18 NA NA NA hsa-miR-15b-5p CHUK 0.773001494057531 1.71784656078957e-16 -0.85746072421144 8.10744991906236e-38 MirTarget -0.225889800417735 5.44303807977529e-08 NA NA NA hsa-miR-16-5p CHUK 0.934012514027655 4.85417898318515e-24 -0.85746072421144 8.10744991906236e-38 miRNAWalker2_validate;miRTarBase;MirTarget -0.228889855351981 2.57589362388376e-08 NA NA NA hsa-miR-195-5p CHUK 0.346502644882604 0.0092562828415903 -0.85746072421144 8.10744991906236e-38 miRNAWalker2_validate;MirTarget -0.157478463247597 2.5847715765755e-07 NA NA NA hsa-miR-223-3p CHUK 1.23291409735619 1.07767240442694e-17 -0.85746072421144 8.10744991906236e-38 miRNAWalker2_validate;miRTarBase -0.158778742351017 2.71041182397134e-09 NA NA NA hsa-miR-23a-3p CHUK 0.761438723382355 4.09310879199257e-27 -0.85746072421144 8.10744991906236e-38 MirTarget -0.426829131699392 2.80265744990605e-16 NA NA NA hsa-miR-342-3p CHUK 1.4124432570595 1.07208971556131e-28 -0.85746072421144 8.10744991906236e-38 miRanda -0.194422482412743 1.9269792265026e-11 NA NA NA hsa-miR-497-5p CHUK 0.227757383708836 0.0600073987853074 -0.85746072421144 8.10744991906236e-38 MirTarget -0.149867793994567 9.91621768564792e-06 NA NA NA hsa-miR-590-3p CHUK 1.13702599385212 3.53435739887793e-22 -0.85746072421144 8.10744991906236e-38 miRanda;mirMAP -0.204551923277616 2.23702640558868e-10 NA NA NA hsa-miR-590-5p CHUK 0.709763558412506 1.11883921359361e-11 -0.85746072421144 8.10744991906236e-38 miRanda -0.177887016696357 2.94637831990317e-06 NA NA NA hsa-miR-106b-5p CRK 1.07509411417907 2.11739194181878e-36 -0.167856948291274 0.0182238472740823 MirTarget;miRNATAP -0.203404916825311 5.88106836473179e-07 NA NA NA hsa-miR-15b-5p CRK 0.773001494057531 1.71784656078957e-16 -0.167856948291274 0.0182238472740823 miRNAWalker2_validate -0.139214010749078 0.00048419995648522 NA NA NA hsa-miR-17-5p CRK 0.494260110870015 3.8348005261e-09 -0.167856948291274 0.0182238472740823 MirTarget;TargetScan;miRNATAP -0.133673655845038 0.00366180497143377 NA NA NA hsa-miR-20a-5p CRK 0.702602695798242 4.06372887613329e-13 -0.167856948291274 0.0182238472740823 MirTarget;miRNATAP -0.167248466528753 1.68675522134757e-05 NA NA NA hsa-miR-590-3p CRK 1.13702599385212 3.53435739887793e-22 -0.167856948291274 0.0182238472740823 mirMAP -0.129122615906663 3.27654339394102e-05 NA NA NA hsa-miR-93-5p CRK 1.37365940377595 2.37567548683245e-46 -0.167856948291274 0.0182238472740823 MirTarget;miRNATAP -0.1262700213507 0.000342359161629049 NA NA NA hsa-let-7g-5p DUSP1 -0.739744008507763 1.07979566264383e-14 0.829179553419252 1.36605708029914e-08 miRNATAP -0.220944976363461 0.00781242962685664 NA NA NA hsa-miR-141-3p DUSP1 -5.87110686537457 1.20877726722907e-85 0.829179553419252 1.36605708029914e-08 TargetScan -0.139221230432874 1.3425203684815e-11 NA NA NA hsa-miR-199b-5p DUSP1 -2.39483476763681 1.04659509514884e-17 0.829179553419252 1.36605708029914e-08 miRanda -0.100585784667068 0.000409857357038969 NA NA NA hsa-miR-200b-3p DUSP1 -1.70383252137161 2.38979336321755e-30 0.829179553419252 1.36605708029914e-08 MirTarget;TargetScan -0.231406092644006 3.45168231961185e-06 NA NA NA hsa-miR-200c-3p DUSP1 -5.40303134829523 2.74173143360645e-94 0.829179553419252 1.36605708029914e-08 MirTarget;miRNATAP -0.159488521039758 2.62057975229539e-12 NA NA NA hsa-miR-22-5p DUSP1 -0.197038086012602 0.106234828461117 0.829179553419252 1.36605708029914e-08 MirTarget;miRNATAP -0.234208499829664 0.000524527178928252 NA NA NA hsa-miR-324-3p DUSP1 -0.197662887871899 0.0298845059559819 0.829179553419252 1.36605708029914e-08 MirTarget -0.414353111443053 4.57035828360551e-06 NA NA NA hsa-miR-425-3p DUSP1 -0.44141152584908 0.000179733368905558 0.829179553419252 1.36605708029914e-08 MirTarget -0.334422629669839 1.25244866856613e-06 NA NA NA hsa-miR-429 DUSP1 -2.16569233119434 2.66862243626443e-37 0.829179553419252 1.36605708029914e-08 MirTarget;PITA;miRanda;miRNATAP -0.236667359731704 2.37640346750526e-08 NA NA NA hsa-miR-361-5p DUSP10 0.0514169367202078 0.382929376393199 1.33331460699794 5.09141165255572e-28 miRanda -0.349337382344068 0.00615889271549384 NA NA NA hsa-miR-362-3p DUSP10 -0.753214251798232 3.0025661608035e-07 1.33331460699794 5.09141165255572e-28 MirTarget;PITA;miRanda;miRNATAP -0.248598693230777 6.01150074020519e-07 NA NA NA hsa-miR-363-3p DUSP10 -1.93551166555337 4.45368477487614e-32 1.33331460699794 5.09141165255572e-28 MirTarget -0.299406417177371 1.17835053146127e-14 NA NA NA hsa-miR-501-5p DUSP10 -1.1103073934745 1.81589804886553e-16 1.33331460699794 5.09141165255572e-28 PITA;miRNATAP -0.291272830203042 9.4321559126449e-09 NA NA NA hsa-miR-199a-5p DUSP14 -1.64658415208633 1.01615659358973e-23 0.715210166580319 4.23187675323074e-18 MirTarget;PITA;miRanda -0.126893419583788 2.33767042887576e-06 NA NA NA hsa-let-7d-5p DUSP16 -0.0696879530236796 0.333110939877203 -0.35719214305059 1.12877061615654e-08 miRNATAP -0.138380359940124 0.00531502614772482 NA NA NA hsa-let-7i-5p DUSP16 0.911372377723717 7.11483853341932e-31 -0.35719214305059 1.12877061615654e-08 miRNATAP -0.16684525994329 3.91303668177045e-05 NA NA NA hsa-miR-140-5p DUSP16 0.504309496243674 3.09884038729031e-11 -0.35719214305059 1.12877061615654e-08 miRNATAP -0.18495136538766 4.14573202671769e-05 NA NA NA hsa-miR-320a DUSP16 0.412740558379182 2.02929519701706e-05 -0.35719214305059 1.12877061615654e-08 MirTarget;miRanda;miRNATAP -0.161499713664576 6.27672882017876e-06 NA NA NA hsa-miR-342-3p DUSP16 1.4124432570595 1.07208971556131e-28 -0.35719214305059 1.12877061615654e-08 miRNATAP -0.128916080202544 2.43409887890348e-07 NA NA NA hsa-miR-361-5p DUSP16 0.0514169367202078 0.382929376393199 -0.35719214305059 1.12877061615654e-08 miRanda -0.202198873365609 0.000938481382399806 NA NA NA hsa-miR-374a-3p DUSP16 1.13863935833993 2.79089304015401e-44 -0.35719214305059 1.12877061615654e-08 mirMAP -0.208099216233919 2.03913457664817e-08 NA NA NA hsa-miR-15a-5p DUSP3 1.42663930007845 1.36006952074963e-57 -0.38729462678252 7.54451473756141e-11 MirTarget;miRNATAP -0.153825034952064 8.75928632172434e-07 NA NA NA hsa-miR-15b-5p DUSP3 0.773001494057531 1.71784656078957e-16 -0.38729462678252 7.54451473756141e-11 MirTarget;miRNATAP -0.132272505248754 0.000110238219685037 NA NA NA hsa-miR-320a DUSP3 0.412740558379182 2.02929519701706e-05 -0.38729462678252 7.54451473756141e-11 mirMAP -0.178517818929446 1.59147830752659e-07 NA NA NA hsa-let-7e-5p DUSP4 -0.727009689927955 1.30690859412163e-11 1.8496287419115 1.43503275739422e-30 miRNATAP -0.412981082578464 2.36328402814289e-06 NA NA NA hsa-let-7g-5p DUSP4 -0.739744008507763 1.07979566264383e-14 1.8496287419115 1.43503275739422e-30 miRNATAP -0.394474294794984 5.53668550071591e-05 NA NA NA hsa-miR-136-5p DUSP4 -1.67696564080585 1.99625416234538e-18 1.8496287419115 1.43503275739422e-30 mirMAP -0.205859435935055 1.75275666250006e-05 NA NA NA hsa-miR-192-3p DUSP4 0.156650099616707 0.483496040900362 1.8496287419115 1.43503275739422e-30 mirMAP -0.131227227596475 0.00282335252961006 NA NA NA hsa-miR-199a-5p DUSP4 -1.64658415208633 1.01615659358973e-23 1.8496287419115 1.43503275739422e-30 miRanda -0.189940199146953 0.000582864371547064 NA NA NA hsa-miR-200b-3p DUSP4 -1.70383252137161 2.38979336321755e-30 1.8496287419115 1.43503275739422e-30 mirMAP -0.410067793606557 1.37617209727113e-12 NA NA NA hsa-miR-200c-3p DUSP4 -5.40303134829523 2.74173143360645e-94 1.8496287419115 1.43503275739422e-30 mirMAP -0.215014579318185 8.55915857637034e-16 NA NA NA hsa-miR-23b-3p DUSP4 -0.533749586990474 2.46924776953771e-10 1.8496287419115 1.43503275739422e-30 mirMAP -0.608732725144679 5.31379272403955e-08 NA NA NA hsa-miR-30b-3p DUSP4 -1.64703050862226 1.89878531036464e-31 1.8496287419115 1.43503275739422e-30 MirTarget -0.539855789651663 1.76018502921981e-19 NA NA NA hsa-miR-429 DUSP4 -2.16569233119434 2.66862243626443e-37 1.8496287419115 1.43503275739422e-30 miRanda;mirMAP -0.423127871583041 3.35215606656149e-18 NA NA NA hsa-miR-23a-3p DUSP5 0.761438723382355 4.09310879199257e-27 -0.458548051928081 0.00161417046018326 MirTarget;miRNATAP -0.314400501698086 0.00312215468854531 NA NA NA hsa-miR-342-3p DUSP6 1.4124432570595 1.07208971556131e-28 -0.592951186102797 2.10566634911436e-08 PITA;miRanda -0.188525143750791 9.56645193811911e-06 NA NA NA hsa-miR-590-3p DUSP6 1.13702599385212 3.53435739887793e-22 -0.592951186102797 2.10566634911436e-08 PITA;miRanda;mirMAP -0.250108188612056 9.7449678704437e-08 NA NA NA hsa-let-7g-3p DUSP7 -0.265047454512772 0.0213585204640049 0.681962396123167 2.30625221329629e-13 MirTarget -0.150663689376634 0.0011212018842208 NA NA NA hsa-miR-141-3p DUSP7 -5.87110686537457 1.20877726722907e-85 0.681962396123167 2.30625221329629e-13 TargetScan -0.109178994180042 6.61325465279735e-17 NA NA NA hsa-miR-149-5p DUSP7 -1.95790336710741 8.46371715052367e-27 0.681962396123167 2.30625221329629e-13 mirMAP -0.135200695556371 3.30601703708426e-07 NA NA NA hsa-miR-193b-3p DUSP7 -0.273325765316079 0.104328826585392 0.681962396123167 2.30625221329629e-13 MirTarget -0.199257205508129 1.04328100993602e-10 NA NA NA hsa-miR-200b-3p DUSP7 -1.70383252137161 2.38979336321755e-30 0.681962396123167 2.30625221329629e-13 TargetScan -0.228265268735622 4.13659694745741e-13 NA NA NA hsa-miR-29a-3p DUSP7 -0.431613225927952 4.10166815070288e-08 0.681962396123167 2.30625221329629e-13 mirMAP -0.389682646388083 3.05227256170056e-09 NA NA NA hsa-miR-29b-3p DUSP7 -0.228125979913806 0.0271621721891603 0.681962396123167 2.30625221329629e-13 mirMAP -0.356702015592564 1.1144673485125e-12 NA NA NA hsa-miR-29c-3p DUSP7 -0.238671318446745 0.0141475322347596 0.681962396123167 2.30625221329629e-13 mirMAP -0.164956536810536 0.00267934248947584 NA NA NA hsa-miR-345-5p DUSP7 -0.953479075875024 8.95459389953487e-14 0.681962396123167 2.30625221329629e-13 mirMAP -0.107596194117961 0.00733614008546174 NA NA NA hsa-miR-362-5p DUSP7 -2.72767654824605 1.34821749679113e-49 0.681962396123167 2.30625221329629e-13 mirMAP -0.195974695450706 9.85643290941727e-17 NA NA NA hsa-miR-429 DUSP7 -2.16569233119434 2.66862243626443e-37 0.681962396123167 2.30625221329629e-13 miRanda;miRNATAP -0.17236074963459 2.44014333991056e-10 NA NA NA hsa-miR-532-3p DUSP7 -1.759223962964 7.9077916669414e-40 0.681962396123167 2.30625221329629e-13 mirMAP -0.25987571886536 2.08250938868974e-14 NA NA NA hsa-miR-625-5p DUSP7 0.153090549230629 0.330314026509869 0.681962396123167 2.30625221329629e-13 mirMAP -0.147426953837095 5.42812886627786e-05 NA NA NA hsa-miR-106b-5p DUSP8 1.07509411417907 2.11739194181878e-36 -0.864588664539548 1.95549068818336e-09 MirTarget;miRNATAP -0.444664883086789 1.45319918642226e-07 NA NA NA hsa-miR-130b-3p DUSP8 1.12788913578446 2.939369462276e-16 -0.864588664539548 1.95549068818336e-09 miRNAWalker2_validate -0.28344029995655 3.60780112882323e-07 NA NA NA hsa-miR-17-5p DUSP8 0.494260110870015 3.8348005261e-09 -0.864588664539548 1.95549068818336e-09 MirTarget;TargetScan;miRNATAP -0.46318838353781 9.74172897590046e-07 NA NA NA hsa-miR-186-5p DUSP8 0.507217561043443 9.04455748270995e-10 -0.864588664539548 1.95549068818336e-09 miRNAWalker2_validate -0.455016768678187 2.0224875070184e-06 NA NA NA hsa-miR-1976 DUSP8 0.343475600930938 0.000360243844871748 -0.864588664539548 1.95549068818336e-09 MirTarget -0.231619384316161 0.00619738496971928 NA NA NA hsa-miR-20a-5p DUSP8 0.702602695798242 4.06372887613329e-13 -0.864588664539548 1.95549068818336e-09 MirTarget;miRNATAP -0.337509479740046 3.05831591615928e-05 NA NA NA hsa-miR-21-5p DUSP8 2.51462371613332 3.30620591950316e-66 -0.864588664539548 1.95549068818336e-09 miRNAWalker2_validate;MirTarget -0.353087048469353 3.75665074357053e-16 NA NA NA hsa-miR-320a DUSP8 0.412740558379182 2.02929519701706e-05 -0.864588664539548 1.95549068818336e-09 miRNAWalker2_validate -0.403377252410527 1.07940167812861e-06 NA NA NA hsa-miR-342-5p DUSP8 1.37011183051517 4.99462376051624e-28 -0.864588664539548 1.95549068818336e-09 mirMAP -0.399026738066711 7.07845759492109e-12 NA NA NA hsa-miR-34a-5p DUSP8 1.07544567720768 1.81510842038009e-20 -0.864588664539548 1.95549068818336e-09 MirTarget -0.380922983442945 4.39369961233687e-09 NA NA NA hsa-miR-374a-5p DUSP8 0.543061152108237 2.19403097299769e-14 -0.864588664539548 1.95549068818336e-09 MirTarget -0.348269502035374 0.0017719557101136 NA NA NA hsa-miR-423-5p DUSP8 0.250929012519631 0.00288495915028486 -0.864588664539548 1.95549068818336e-09 MirTarget -0.328569268864522 0.000710844940487825 NA NA NA hsa-miR-450b-5p DUSP8 0.404819502355575 0.00357671373841274 -0.864588664539548 1.95549068818336e-09 miRNATAP -0.213628655638537 0.000243679118695275 NA NA NA hsa-miR-452-3p DUSP8 1.72039996672257 1.35748079442153e-22 -0.864588664539548 1.95549068818336e-09 mirMAP -0.259798787170392 1.7873132702483e-09 NA NA NA hsa-miR-590-5p DUSP8 0.709763558412506 1.11883921359361e-11 -0.864588664539548 1.95549068818336e-09 MirTarget;PITA;miRanda;miRNATAP -0.258882168502477 0.000617620672465011 NA NA NA hsa-miR-671-5p DUSP8 0.740296481994777 8.07053661008188e-07 -0.864588664539548 1.95549068818336e-09 mirMAP -0.266494553201409 5.98815474956724e-07 NA NA NA hsa-miR-93-5p DUSP8 1.37365940377595 2.37567548683245e-46 -0.864588664539548 1.95549068818336e-09 miRNAWalker2_validate;MirTarget;miRNATAP -0.481210488488138 1.79654240795378e-11 NA NA NA hsa-let-7b-5p DUSP9 0.770868211539597 6.63408323707647e-21 -8.47300465766044 6.20866415810405e-76 miRNATAP -3.27570644944728 5.71288963685996e-21 NA NA NA hsa-let-7i-5p DUSP9 0.911372377723717 7.11483853341932e-31 -8.47300465766044 6.20866415810405e-76 miRNATAP -2.94037788220768 1.78414580926698e-16 NA NA NA hsa-miR-106b-5p DUSP9 1.07509411417907 2.11739194181878e-36 -8.47300465766044 6.20866415810405e-76 mirMAP -2.73107298192139 2.52051463548103e-17 NA NA NA hsa-miR-132-3p DUSP9 0.291409674711894 0.000912684337101876 -8.47300465766044 6.20866415810405e-76 MirTarget;miRNATAP -1.41464909951851 0.000104968806610677 NA NA NA hsa-miR-17-5p DUSP9 0.494260110870015 3.8348005261e-09 -8.47300465766044 6.20866415810405e-76 mirMAP -1.47691010111931 8.3502605026207e-05 NA NA NA hsa-miR-194-5p DUSP9 0.62222617402691 0.00659826803316099 -8.47300465766044 6.20866415810405e-76 MirTarget;miRNATAP -0.410609318905252 0.00323914597880395 NA NA NA hsa-miR-20a-5p DUSP9 0.702602695798242 4.06372887613329e-13 -8.47300465766044 6.20866415810405e-76 mirMAP -2.04685418479619 6.27232813804845e-11 NA NA NA hsa-miR-338-3p DUSP9 0.906250377628867 2.76970900371139e-15 -8.47300465766044 6.20866415810405e-76 mirMAP -1.86168504094775 8.15769567401582e-13 NA NA NA hsa-miR-361-3p DUSP9 1.08992546227594 1.13197240706704e-36 -8.47300465766044 6.20866415810405e-76 mirMAP -3.02997274581526 5.00908950524437e-22 NA NA NA hsa-miR-452-5p DUSP9 2.05325688842141 2.82238393643084e-40 -8.47300465766044 6.20866415810405e-76 MirTarget -1.77222283436991 1.71235685621992e-25 NA NA NA hsa-miR-590-3p EGF 1.13702599385212 3.53435739887793e-22 -6.49821423238405 1.01144352508784e-64 miRanda -1.60204014811855 6.03930462045536e-16 NA NA NA hsa-miR-629-3p EGF 1.09330044556689 2.9533160808356e-14 -6.49821423238405 1.01144352508784e-64 miRNATAP -0.695727142965681 6.88083628515494e-05 NA NA NA hsa-miR-141-3p EGFR -5.87110686537457 1.20877726722907e-85 1.04566425778521 6.25371695782468e-12 MirTarget -0.142272170209372 5.89271101342102e-11 26025929 Treatment with the EGFR inhibitor AG1478 or overexpression of miR141 blocked the activity of ERK downstream of EGFR and inhibited KLF8-depndent cell invasiveness proliferation and viability in cell culture and invasive growth and lung metastasis in nude mice metastasis breast cancer hsa-miR-188-5p EGFR -1.74586655806628 1.50431624674552e-28 1.04566425778521 6.25371695782468e-12 mirMAP -0.266112483430454 2.11374456409575e-07 NA NA NA hsa-miR-199a-3p EGFR -1.61607426368083 1.97964980193147e-26 1.04566425778521 6.25371695782468e-12 mirMAP -0.201778068439938 0.000117100162581278 NA NA NA hsa-miR-199b-3p EGFR -1.61804389801139 1.97668652730486e-26 1.04566425778521 6.25371695782468e-12 mirMAP -0.201560537599491 0.000116841770931786 NA NA NA hsa-miR-27b-3p EGFR -0.699527231242518 1.07356023759234e-15 1.04566425778521 6.25371695782468e-12 MirTarget;miRNATAP -0.42975046882661 5.91405803681307e-06 NA NA NA hsa-miR-335-5p EGFR -2.09515619961552 1.03765771499548e-25 1.04566425778521 6.25371695782468e-12 miRNAWalker2_validate -0.130866439253699 0.00119751239304092 NA NA NA hsa-miR-362-5p EGFR -2.72767654824605 1.34821749679113e-49 1.04566425778521 6.25371695782468e-12 mirMAP -0.275325520610269 1.67616170773246e-12 NA NA NA hsa-miR-375 EGFR -1.46468479447701 9.20596529469647e-07 1.04566425778521 6.25371695782468e-12 miRanda -0.116635350053781 3.88231671031593e-05 NA NA NA hsa-miR-501-5p EGFR -1.1103073934745 1.81589804886553e-16 1.04566425778521 6.25371695782468e-12 mirMAP -0.351439828127429 5.20411928127982e-09 NA NA NA hsa-miR-654-3p EGFR -1.07948413911035 1.47901771988248e-07 1.04566425778521 6.25371695782468e-12 mirMAP -0.119137373119274 0.00494226674362834 NA NA NA hsa-miR-125a-5p ELK1 -0.561874059994802 7.3931856356891e-13 0.336289227504367 2.16498541381608e-10 miRanda -0.132903172942065 0.0003317935240418 NA NA NA hsa-miR-429 ELK1 -2.16569233119434 2.66862243626443e-37 0.336289227504367 2.16498541381608e-10 miRNATAP -0.116863518433536 7.56828088575439e-15 NA NA NA hsa-miR-660-5p ELK1 -1.20833564582661 8.48975910642834e-23 0.336289227504367 2.16498541381608e-10 MirTarget -0.137463435624553 5.718488787413e-10 NA NA NA hsa-let-7a-3p ELK4 0.0677487960013088 0.460458477653989 -0.29745212431442 0.00119959799351549 mirMAP -0.210361905947288 0.000158928056653216 NA NA NA hsa-let-7i-5p ELK4 0.911372377723717 7.11483853341932e-31 -0.29745212431442 0.00119959799351549 miRNATAP -0.154051111749496 0.00926024765178928 NA NA NA hsa-miR-106b-5p ELK4 1.07509411417907 2.11739194181878e-36 -0.29745212431442 0.00119959799351549 miRNATAP -0.356737614746947 6.97389986675183e-12 NA NA NA hsa-miR-148a-5p ELK4 0.415500302855613 0.000691460831436767 -0.29745212431442 0.00119959799351549 mirMAP -0.124267130567556 0.00265327292296932 NA NA NA hsa-miR-16-1-3p ELK4 1.51429140700091 3.17219833254498e-37 -0.29745212431442 0.00119959799351549 mirMAP -0.13700902455604 0.000391946648072831 NA NA NA hsa-miR-181a-5p ELK4 1.11111114875339 3.97880443756442e-29 -0.29745212431442 0.00119959799351549 mirMAP -0.14977262107914 0.00143942815755075 NA NA NA hsa-miR-181b-5p ELK4 1.49054296272357 3.69051660739368e-41 -0.29745212431442 0.00119959799351549 mirMAP -0.141804086100513 0.000429791523924003 NA NA NA hsa-miR-196a-5p ELK4 0.440858887700369 2.0077143292463e-05 -0.29745212431442 0.00119959799351549 miRNATAP -0.163641857225478 0.000792785723333561 NA NA NA hsa-miR-19a-3p ELK4 0.722913586880779 2.76301458932381e-10 -0.29745212431442 0.00119959799351549 mirMAP -0.120957241311661 0.00526399267237063 NA NA NA hsa-miR-19b-3p ELK4 0.195940928879427 0.0300512922542325 -0.29745212431442 0.00119959799351549 mirMAP -0.165355849948096 0.00353917208405045 NA NA NA hsa-miR-26b-5p ELK4 -0.251437253429904 0.00270935785098697 -0.29745212431442 0.00119959799351549 mirMAP -0.188671849181901 0.00196186288959499 NA NA NA hsa-miR-361-5p ELK4 0.0514169367202078 0.382929376393199 -0.29745212431442 0.00119959799351549 miRanda;mirMAP -0.395738612954118 6.65844005014745e-06 NA NA NA hsa-miR-365a-3p ELK4 0.80809616164259 2.36039522526e-12 -0.29745212431442 0.00119959799351549 mirMAP -0.184115533382066 1.41655912490033e-05 NA NA NA hsa-miR-590-3p ELK4 1.13702599385212 3.53435739887793e-22 -0.29745212431442 0.00119959799351549 miRanda;miRNATAP -0.119128647841391 0.00338532988877756 NA NA NA hsa-miR-590-5p ELK4 0.709763558412506 1.11883921359361e-11 -0.29745212431442 0.00119959799351549 mirMAP -0.151213739686029 0.00137407976993852 NA NA NA hsa-miR-92b-3p ELK4 0.418630595140165 6.50466149211154e-05 -0.29745212431442 0.00119959799351549 mirMAP -0.166368899683372 0.00054986142670669 NA NA NA hsa-miR-106a-5p FAS -0.830908656792615 2.67547872901508e-10 1.2781702198996 1.39159398357076e-35 miRNAWalker2_validate;miRTarBase -0.17563422723919 0.000166805410564044 22431000;27142596 miR 106a is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS; Bioinformatic analysis combining with validation experiments identified FAS as a direct target of miR-106a; Moreover a significant inverse correlation was found between miR-106a and FAS expression not only in gastric cancer cell lines but also in gastric cancer specimens; Taken together these findings suggest that ectopicly overexpressed miR-106a may play an oncogenic role in gastric carcinogenesis and impair extrinsic apoptotic pathway through targeting FAS;Functional experiment ascertained that miR-106a interacted with FAS and mediated caspase3 pathway tumorigenesis; gastric cancer;gastric cancer hsa-miR-23b-3p FAS -0.533749586990474 2.46924776953771e-10 1.2781702198996 1.39159398357076e-35 miRNATAP -0.365469144431479 5.00602609064883e-07 24356489 Moreover over-expression of Fas rescued the pro-proliferation effect of miR-23 indicating Fas is a direct mediator of miR-23 functions; Furthermore contrast to miR-23a/b which was up regulated the Fas expression level was down-regulated and inversely correlated with miR-23 in split radiation induced lymphoma tissue samples; Finally our data also indicates that miR-23a could repress Fas much more potent than miR-23b and the additional region besides conserved seed pairing enables miR-23a's higher regulation lymphoma hsa-let-7e-5p FASLG -0.727009689927955 1.30690859412163e-11 3.49526870659822 3.0591043026913e-47 miRNATAP -0.956759956622149 2.07254587441987e-12 NA NA NA hsa-let-7g-5p FASLG -0.739744008507763 1.07979566264383e-14 3.49526870659822 3.0591043026913e-47 miRNATAP -0.527566684352497 0.00071592111786537 NA NA NA hsa-miR-199a-5p FASLG -1.64658415208633 1.01615659358973e-23 3.49526870659822 3.0591043026913e-47 miRanda -0.587327373538791 5.90733830602172e-12 NA NA NA hsa-miR-362-3p FASLG -0.753214251798232 3.0025661608035e-07 3.49526870659822 3.0591043026913e-47 miRanda -0.346233134453532 0.00119742349456323 NA NA NA hsa-miR-126-5p FGF1 0.785607261431085 5.77058629454465e-13 -3.80115931488584 6.45925676739727e-49 mirMAP -0.412699157217257 0.00526602775124141 NA NA NA hsa-miR-146b-3p FGF1 1.20941495066078 2.12939149602665e-10 -3.80115931488584 6.45925676739727e-49 miRNATAP -0.412681804700488 8.7577650210875e-07 NA NA NA hsa-miR-16-1-3p FGF1 1.51429140700091 3.17219833254498e-37 -3.80115931488584 6.45925676739727e-49 mirMAP -0.964767375204906 2.41440232347677e-15 NA NA NA hsa-miR-186-5p FGF1 0.507217561043443 9.04455748270995e-10 -3.80115931488584 6.45925676739727e-49 mirMAP -1.1691556044543 1.5936381390255e-09 NA NA NA hsa-miR-18a-5p FGF1 0.936704393213466 1.05064580570579e-10 -3.80115931488584 6.45925676739727e-49 MirTarget -0.380773292559268 0.00062635862331619 NA NA NA hsa-miR-193a-3p FGF1 0.849206638484406 3.68101781083335e-14 -3.80115931488584 6.45925676739727e-49 PITA -0.799485713529985 1.34176070169954e-08 NA NA NA hsa-miR-21-5p FGF1 2.51462371613332 3.30620591950316e-66 -3.80115931488584 6.45925676739727e-49 MirTarget -1.0333718022015 1.64441254488335e-35 NA NA NA hsa-miR-2355-5p FGF1 1.57515081110162 3.54962327490702e-48 -3.80115931488584 6.45925676739727e-49 MirTarget -1.06613568021987 4.20053987792956e-17 NA NA NA hsa-miR-28-5p FGF1 0.461962042257226 3.32424690573327e-11 -3.80115931488584 6.45925676739727e-49 miRanda -0.947270161202561 5.17246250727041e-05 NA NA NA hsa-miR-320a FGF1 0.412740558379182 2.02929519701706e-05 -3.80115931488584 6.45925676739727e-49 miRanda -0.542494284439551 0.00150132216990968 NA NA NA hsa-miR-330-5p FGF1 1.44960468659754 2.12131210588035e-45 -3.80115931488584 6.45925676739727e-49 miRanda;miRNATAP -1.30237436907411 7.22656393944219e-23 NA NA NA hsa-miR-374a-3p FGF1 1.13863935833993 2.79089304015401e-44 -3.80115931488584 6.45925676739727e-49 mirMAP -1.40971713192021 1.79713277496189e-16 NA NA NA hsa-miR-3913-5p FGF1 0.136365354811444 0.24239516424369 -3.80115931488584 6.45925676739727e-49 mirMAP -0.458269193077043 0.00234831890309927 NA NA NA hsa-miR-484 FGF1 0.571987778099603 9.67278224458421e-10 -3.80115931488584 6.45925676739727e-49 MirTarget;PITA;miRNATAP -0.539151528053616 0.00200972026686984 NA NA NA hsa-miR-550a-5p FGF1 0.764341426122997 7.62129848116256e-09 -3.80115931488584 6.45925676739727e-49 MirTarget -0.542780642335613 1.80477226060982e-05 NA NA NA hsa-miR-576-5p FGF1 1.06681109513983 5.69294424466526e-24 -3.80115931488584 6.45925676739727e-49 PITA;mirMAP -1.26887442737172 6.80528442258741e-20 NA NA NA hsa-miR-590-5p FGF1 0.709763558412506 1.11883921359361e-11 -3.80115931488584 6.45925676739727e-49 MirTarget;miRanda;miRNATAP -0.760247687860989 6.80195819553776e-07 NA NA NA hsa-miR-629-5p FGF1 1.73389921851483 5.39614356468007e-48 -3.80115931488584 6.45925676739727e-49 MirTarget -1.38540287626161 3.01408249241889e-38 NA NA NA hsa-let-7e-5p FGF11 -0.727009689927955 1.30690859412163e-11 2.23617192158805 1.8788982620777e-26 mirMAP;miRNATAP -0.32446922393154 0.00441188606836517 NA NA NA hsa-let-7g-5p FGF11 -0.739744008507763 1.07979566264383e-14 2.23617192158805 1.8788982620777e-26 mirMAP;miRNATAP -0.714675969532457 9.32950813786375e-09 NA NA NA hsa-miR-10a-5p FGF11 -1.17164272592931 4.86621098042279e-24 2.23617192158805 1.8788982620777e-26 mirMAP -0.519537627190446 1.90326383611477e-07 NA NA NA hsa-miR-125a-5p FGF11 -0.561874059994802 7.3931856356891e-13 2.23617192158805 1.8788982620777e-26 mirMAP -0.491473322603107 0.00168737579895867 NA NA NA hsa-miR-125b-5p FGF11 -0.825456421494266 2.13029877878434e-15 2.23617192158805 1.8788982620777e-26 mirMAP -0.790229628434622 2.28241804372165e-12 NA NA NA hsa-miR-193b-3p FGF11 -0.273325765316079 0.104328826585392 2.23617192158805 1.8788982620777e-26 miRNAWalker2_validate -0.264997262620483 0.000378170532610284 NA NA NA hsa-miR-199a-5p FGF11 -1.64658415208633 1.01615659358973e-23 2.23617192158805 1.8788982620777e-26 miRanda -0.365321328288127 2.0503722571563e-07 NA NA NA hsa-miR-199b-5p FGF11 -2.39483476763681 1.04659509514884e-17 2.23617192158805 1.8788982620777e-26 miRanda -0.267087192579251 3.70589364602002e-10 NA NA NA hsa-miR-217 FGF11 -1.32414431829977 4.20138196453017e-06 2.23617192158805 1.8788982620777e-26 PITA;miRanda -0.217410327744056 3.17577593872614e-07 NA NA NA hsa-miR-324-5p FGF11 -0.487750893426456 3.74472736457965e-05 2.23617192158805 1.8788982620777e-26 miRanda -0.440327954994482 2.67066434439899e-05 NA NA NA hsa-miR-335-5p FGF11 -2.09515619961552 1.03765771499548e-25 2.23617192158805 1.8788982620777e-26 miRNAWalker2_validate;mirMAP -0.361050653609898 2.98033784759218e-10 NA NA NA hsa-miR-532-3p FGF11 -1.759223962964 7.9077916669414e-40 2.23617192158805 1.8788982620777e-26 mirMAP -0.722489323765386 5.00428763930247e-20 NA NA NA hsa-miR-107 FGF12 0.140046250553248 0.0943611632552367 -0.544326533476572 0.000268476484930876 miRanda -0.308318107900707 0.0020791655765071 NA NA NA hsa-miR-142-5p FGF12 1.88417391525707 1.2096808039882e-27 -0.544326533476572 0.000268476484930876 miRNATAP -0.318634287216316 6.22273374967518e-14 NA NA NA hsa-miR-17-5p FGF12 0.494260110870015 3.8348005261e-09 -0.544326533476572 0.000268476484930876 TargetScan -0.263868289343099 0.00688746603358349 NA NA NA hsa-miR-2355-3p FGF12 1.32757890426926 1.88016636795886e-18 -0.544326533476572 0.000268476484930876 MirTarget;miRNATAP -0.153811131758858 0.00389207620799374 NA NA NA hsa-miR-342-3p FGF12 1.4124432570595 1.07208971556131e-28 -0.544326533476572 0.000268476484930876 miRanda -0.356290596206616 1.17638486726232e-09 NA NA NA hsa-miR-455-5p FGF12 0.773674551205946 2.12957541541474e-09 -0.544326533476572 0.000268476484930876 miRanda -0.253534570625561 4.85862913572717e-05 NA NA NA hsa-miR-576-5p FGF12 1.06681109513983 5.69294424466526e-24 -0.544326533476572 0.000268476484930876 mirMAP -0.242190473439388 0.000932815704136755 NA NA NA hsa-miR-590-3p FGF12 1.13702599385212 3.53435739887793e-22 -0.544326533476572 0.000268476484930876 mirMAP -0.41088644924644 2.2750931713891e-10 NA NA NA hsa-miR-616-5p FGF12 0.913426384742148 3.78418389333709e-09 -0.544326533476572 0.000268476484930876 MirTarget -0.148821746829177 0.00515708784404577 NA NA NA hsa-miR-142-5p FGF13 1.88417391525707 1.2096808039882e-27 -0.355285378300594 0.0111820560270456 PITA -0.114950681929534 0.00514428395065014 NA NA NA hsa-miR-340-5p FGF13 1.14479851941741 2.91936881701444e-15 -0.355285378300594 0.0111820560270456 MirTarget -0.187712863175925 0.000225631107920348 NA NA NA hsa-miR-455-5p FGF13 0.773674551205946 2.12957541541474e-09 -0.355285378300594 0.0111820560270456 PITA;miRanda -0.213004300489336 0.000261097737029612 NA NA NA hsa-miR-7-1-3p FGF13 0.544601828025304 5.33830451326047e-07 -0.355285378300594 0.0111820560270456 MirTarget;mirMAP -0.279000874186576 6.71817165068062e-05 NA NA NA hsa-miR-103a-3p FGF18 0.779373475434461 7.37867196796994e-20 -1.06341529740156 1.38965890583684e-07 miRNATAP -0.447891739165942 0.00037020775263271 NA NA NA hsa-miR-107 FGF18 0.140046250553248 0.0943611632552367 -1.06341529740156 1.38965890583684e-07 miRNATAP -0.57929754380422 2.05446408358056e-05 NA NA NA hsa-miR-15a-5p FGF18 1.42663930007845 1.36006952074963e-57 -1.06341529740156 1.38965890583684e-07 miRNATAP -0.534405765807597 4.02497295632232e-07 NA NA NA hsa-miR-16-5p FGF18 0.934012514027655 4.85417898318515e-24 -1.06341529740156 1.38965890583684e-07 miRNATAP -0.347307673451457 0.00249430704083827 NA NA NA hsa-miR-21-5p FGF18 2.51462371613332 3.30620591950316e-66 -1.06341529740156 1.38965890583684e-07 miRNATAP -0.240173567040242 0.000131541472622255 NA NA NA hsa-miR-330-5p FGF18 1.44960468659754 2.12131210588035e-45 -1.06341529740156 1.38965890583684e-07 PITA;miRanda;miRNATAP -0.339622639535814 0.000407996785668723 NA NA NA hsa-miR-421 FGF18 0.313155739887734 0.020433534776003 -1.06341529740156 1.38965890583684e-07 miRanda -0.270977518576723 0.00177389655223298 NA NA NA hsa-miR-590-5p FGF18 0.709763558412506 1.11883921359361e-11 -1.06341529740156 1.38965890583684e-07 miRanda;miRNATAP -0.299844534788332 0.00454562101475503 NA NA NA hsa-let-7a-3p FGF2 0.0677487960013088 0.460458477653989 -0.589674911482514 4.9097503791125e-05 mirMAP -0.413855026311993 2.64122269531956e-06 NA NA NA hsa-miR-107 FGF2 0.140046250553248 0.0943611632552367 -0.589674911482514 4.9097503791125e-05 MirTarget;PITA;miRanda;miRNATAP -0.252364961790113 0.00988319837104476 NA NA NA hsa-miR-146a-5p FGF2 1.04938133739924 7.51013231709992e-12 -0.589674911482514 4.9097503791125e-05 mirMAP -0.210539194206361 3.35191542749017e-05 NA NA NA hsa-miR-15a-5p FGF2 1.42663930007845 1.36006952074963e-57 -0.589674911482514 4.9097503791125e-05 MirTarget;miRNATAP -0.255449530855187 0.000776459741728151 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-3p FGF2 1.49422666971434 5.44139893275088e-29 -0.589674911482514 4.9097503791125e-05 mirMAP -0.216697138822269 8.55843255884349e-05 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-1-3p FGF2 1.51429140700091 3.17219833254498e-37 -0.589674911482514 4.9097503791125e-05 mirMAP -0.163232052977134 0.00821869739056501 NA NA NA hsa-miR-16-2-3p FGF2 1.3046118743965 4.17207934608428e-19 -0.589674911482514 4.9097503791125e-05 mirMAP -0.186446224772941 0.000351536882101309 NA NA NA hsa-miR-16-5p FGF2 0.934012514027655 4.85417898318515e-24 -0.589674911482514 4.9097503791125e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.242955350739253 0.00300895920388753 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-192-5p FGF2 0.442478872410106 0.0669238175123954 -0.589674911482514 4.9097503791125e-05 miRNAWalker2_validate -0.102614170997363 0.00212550043678563 NA NA NA hsa-miR-19b-1-5p FGF2 0.66692013055553 1.55789130176287e-09 -0.589674911482514 4.9097503791125e-05 mirMAP -0.213543395777736 0.00295255172655819 NA NA NA hsa-miR-21-5p FGF2 2.51462371613332 3.30620591950316e-66 -0.589674911482514 4.9097503791125e-05 mirMAP -0.126618960975775 0.00490413708016251 NA NA NA hsa-miR-215-5p FGF2 1.57223951497888 6.18833867819653e-10 -0.589674911482514 4.9097503791125e-05 miRNAWalker2_validate -0.15555129616708 3.63011104027706e-07 NA NA NA hsa-miR-32-5p FGF2 0.407826130035097 7.26884631998646e-06 -0.589674911482514 4.9097503791125e-05 miRNAWalker2_validate -0.39260283335843 7.71884095801517e-06 NA NA NA hsa-miR-338-5p FGF2 0.628429807914222 1.27575140717947e-06 -0.589674911482514 4.9097503791125e-05 mirMAP -0.215263032074881 0.000575910517976575 NA NA NA hsa-miR-361-5p FGF2 0.0514169367202078 0.382929376393199 -0.589674911482514 4.9097503791125e-05 mirMAP -0.372320972807354 0.00839299302616162 NA NA NA hsa-miR-374a-3p FGF2 1.13863935833993 2.79089304015401e-44 -0.589674911482514 4.9097503791125e-05 mirMAP -0.301198297479784 0.0005177785699223 NA NA NA hsa-miR-374b-5p FGF2 0.0804104684417872 0.365593963035077 -0.589674911482514 4.9097503791125e-05 mirMAP -0.414924088923791 5.30808312664893e-06 NA NA NA hsa-miR-590-3p FGF2 1.13702599385212 3.53435739887793e-22 -0.589674911482514 4.9097503791125e-05 miRanda;mirMAP -0.223542377598034 0.000531270043941063 NA NA NA hsa-miR-590-5p FGF2 0.709763558412506 1.11883921359361e-11 -0.589674911482514 4.9097503791125e-05 miRanda;mirMAP -0.262470036573759 0.000472851744537926 NA NA NA hsa-miR-338-3p FGF5 0.906250377628867 2.76970900371139e-15 -1.83723658792888 9.61171733928648e-07 miRanda -0.523502317862385 0.00291245665472794 NA NA NA hsa-miR-455-5p FGF5 0.773674551205946 2.12957541541474e-09 -1.83723658792888 9.61171733928648e-07 miRanda -0.445706621017696 0.00510035663278383 NA NA NA hsa-miR-126-5p FGF7 0.785607261431085 5.77058629454465e-13 -1.97624310317764 2.86806708934501e-20 miRNATAP -0.35417145796188 0.00148560446741828 NA NA NA hsa-miR-155-5p FGF7 3.26274490570809 5.06841441826518e-51 -1.97624310317764 2.86806708934501e-20 miRNAWalker2_validate;miRTarBase;mirMAP;miRNATAP -0.209194847453416 1.86189427308698e-05 NA NA NA hsa-miR-15a-5p FGF7 1.42663930007845 1.36006952074963e-57 -1.97624310317764 2.86806708934501e-20 miRTarBase;miRNATAP -0.847236705144023 1.19914061552758e-13 NA NA NA hsa-miR-15b-5p FGF7 0.773001494057531 1.71784656078957e-16 -1.97624310317764 2.86806708934501e-20 miRNATAP -0.675844673945504 9.2634659069312e-08 NA NA NA hsa-miR-16-1-3p FGF7 1.51429140700091 3.17219833254498e-37 -1.97624310317764 2.86806708934501e-20 mirMAP -0.479652584917845 3.96398023440139e-07 NA NA NA hsa-miR-16-2-3p FGF7 1.3046118743965 4.17207934608428e-19 -1.97624310317764 2.86806708934501e-20 mirMAP -0.22562888615642 0.00555719154096863 NA NA NA hsa-miR-16-5p FGF7 0.934012514027655 4.85417898318515e-24 -1.97624310317764 2.86806708934501e-20 miRNATAP -0.562305081893864 8.31032538296145e-06 NA NA NA hsa-miR-20a-5p FGF7 0.702602695798242 4.06372887613329e-13 -1.97624310317764 2.86806708934501e-20 miRNAWalker2_validate -0.56349110002559 6.1764049927491e-06 NA NA NA hsa-miR-27a-3p FGF7 0.558934437526245 1.44256383086177e-12 -1.97624310317764 2.86806708934501e-20 MirTarget -0.491043390020319 0.00156230248699803 NA NA NA hsa-miR-340-5p FGF7 1.14479851941741 2.91936881701444e-15 -1.97624310317764 2.86806708934501e-20 mirMAP -0.369328887879201 7.08248065738976e-06 NA NA NA hsa-miR-374a-3p FGF7 1.13863935833993 2.79089304015401e-44 -1.97624310317764 2.86806708934501e-20 miRNATAP -0.593508361010668 9.50745159268841e-06 NA NA NA hsa-miR-452-5p FGF7 2.05325688842141 2.82238393643084e-40 -1.97624310317764 2.86806708934501e-20 mirMAP -0.373676554420803 1.20947812660623e-07 NA NA NA hsa-miR-455-3p FGF7 0.171798655137046 0.261841668213493 -1.97624310317764 2.86806708934501e-20 PITA;miRNATAP -0.304968993458052 0.00019698398945574 NA NA NA hsa-miR-486-5p FGF7 1.16748143760361 1.68410465883829e-08 -1.97624310317764 2.86806708934501e-20 MirTarget;miRanda -0.214937151224756 0.000278538413773526 NA NA NA hsa-miR-542-3p FGF7 0.431147917094433 0.000254981247606435 -1.97624310317764 2.86806708934501e-20 miRanda -0.315059448630938 0.00298991790572798 NA NA NA hsa-miR-590-3p FGF7 1.13702599385212 3.53435739887793e-22 -1.97624310317764 2.86806708934501e-20 PITA;miRanda;mirMAP;miRNATAP -0.368850958190117 0.000229960701103488 NA NA NA hsa-miR-590-5p FGF7 0.709763558412506 1.11883921359361e-11 -1.97624310317764 2.86806708934501e-20 PITA;miRanda -0.348010220978055 0.00292627950694944 NA NA NA hsa-miR-616-5p FGF7 0.913426384742148 3.78418389333709e-09 -1.97624310317764 2.86806708934501e-20 mirMAP -0.298120733208393 0.000201559767102017 NA NA NA hsa-miR-7-1-3p FGF7 0.544601828025304 5.33830451326047e-07 -1.97624310317764 2.86806708934501e-20 mirMAP -0.43572294285412 0.000128343842961541 NA NA NA hsa-miR-132-3p FGF9 0.291409674711894 0.000912684337101876 -7.89303410861971 6.51626529576473e-68 mirMAP -1.49278300216127 2.05673100310755e-05 NA NA NA hsa-miR-140-3p FGF9 0.989350547007025 6.14964028267239e-25 -7.89303410861971 6.51626529576473e-68 miRNATAP -2.36734754388086 1.68509808638843e-16 NA NA NA hsa-miR-140-5p FGF9 0.504309496243674 3.09884038729031e-11 -7.89303410861971 6.51626529576473e-68 miRNAWalker2_validate;PITA;miRanda;miRNATAP -2.14696810755974 4.91581299417391e-08 NA NA NA hsa-miR-142-3p FGF9 1.88928758773299 2.72985643829893e-22 -7.89303410861971 6.51626529576473e-68 miRanda -1.28510812329466 4.80178741191123e-20 NA NA NA hsa-miR-142-5p FGF9 1.88417391525707 1.2096808039882e-27 -7.89303410861971 6.51626529576473e-68 mirMAP -1.5849190428124 2.31403871037857e-25 NA NA NA hsa-miR-143-3p FGF9 0.544259011512089 1.71102635165867e-05 -7.89303410861971 6.51626529576473e-68 miRNATAP -0.918749044179476 0.000137890724045419 NA NA NA hsa-miR-155-5p FGF9 3.26274490570809 5.06841441826518e-51 -7.89303410861971 6.51626529576473e-68 miRNATAP -1.45574467015398 9.91351979840903e-43 NA NA NA hsa-miR-15a-5p FGF9 1.42663930007845 1.36006952074963e-57 -7.89303410861971 6.51626529576473e-68 miRNATAP -3.59565285580255 6.46550650472585e-46 NA NA NA hsa-miR-15b-5p FGF9 0.773001494057531 1.71784656078957e-16 -7.89303410861971 6.51626529576473e-68 miRNATAP -2.62381325572957 2.49932882811215e-18 NA NA NA hsa-miR-16-2-3p FGF9 1.3046118743965 4.17207934608428e-19 -7.89303410861971 6.51626529576473e-68 mirMAP -1.47968858497529 1.56368473036667e-14 NA NA NA hsa-miR-16-5p FGF9 0.934012514027655 4.85417898318515e-24 -7.89303410861971 6.51626529576473e-68 miRNATAP -2.93941999209394 8.19865698545329e-24 NA NA NA hsa-miR-181a-5p FGF9 1.11111114875339 3.97880443756442e-29 -7.89303410861971 6.51626529576473e-68 mirMAP -3.01683259489948 6.2935151356822e-31 NA NA NA hsa-miR-181b-5p FGF9 1.49054296272357 3.69051660739368e-41 -7.89303410861971 6.51626529576473e-68 mirMAP -2.88764658364589 2.42529744328292e-40 NA NA NA hsa-miR-181c-5p FGF9 0.762784646696248 4.48373118147729e-10 -7.89303410861971 6.51626529576473e-68 mirMAP -0.974034125284438 7.24711889757936e-05 NA NA NA hsa-miR-186-5p FGF9 0.507217561043443 9.04455748270995e-10 -7.89303410861971 6.51626529576473e-68 mirMAP -2.38550261599293 2.61095557708383e-11 NA NA NA hsa-miR-195-3p FGF9 0.808592887366705 6.8151241038711e-09 -7.89303410861971 6.51626529576473e-68 mirMAP;miRNATAP -1.1840868478066 3.6353294065925e-08 NA NA NA hsa-miR-195-5p FGF9 0.346502644882604 0.0092562828415903 -7.89303410861971 6.51626529576473e-68 miRNATAP -0.834949314691814 0.000307067445099101 NA NA NA hsa-miR-320a FGF9 0.412740558379182 2.02929519701706e-05 -7.89303410861971 6.51626529576473e-68 mirMAP;miRNATAP -1.74376828066047 2.39519261181127e-08 NA NA NA hsa-miR-320b FGF9 0.300497419754843 0.0245219177384172 -7.89303410861971 6.51626529576473e-68 mirMAP;miRNATAP -0.829189781584702 0.000327781913785607 NA NA NA hsa-miR-330-5p FGF9 1.44960468659754 2.12131210588035e-45 -7.89303410861971 6.51626529576473e-68 miRanda;miRNATAP -3.09466572534346 1.25369400690336e-40 NA NA NA hsa-miR-338-3p FGF9 0.906250377628867 2.76970900371139e-15 -7.89303410861971 6.51626529576473e-68 PITA;miRanda;miRNATAP -1.75095892002454 3.06094850352792e-12 NA NA NA hsa-miR-338-5p FGF9 0.628429807914222 1.27575140717947e-06 -7.89303410861971 6.51626529576473e-68 miRNATAP -1.18083105634736 6.1007334937809e-07 NA NA NA hsa-miR-374a-5p FGF9 0.543061152108237 2.19403097299769e-14 -7.89303410861971 6.51626529576473e-68 mirMAP -3.20984621216012 2.95766906510555e-15 NA NA NA hsa-miR-450b-5p FGF9 0.404819502355575 0.00357671373841274 -7.89303410861971 6.51626529576473e-68 mirMAP;miRNATAP -0.585609878563624 0.00843223916148081 NA NA NA hsa-miR-455-5p FGF9 0.773674551205946 2.12957541541474e-09 -7.89303410861971 6.51626529576473e-68 miRanda -2.01014500445414 1.06761241000351e-19 NA NA NA hsa-miR-486-5p FGF9 1.16748143760361 1.68410465883829e-08 -7.89303410861971 6.51626529576473e-68 miRanda;miRNATAP -0.665125032723195 4.27507860555687e-06 NA NA NA hsa-miR-590-3p FGF9 1.13702599385212 3.53435739887793e-22 -7.89303410861971 6.51626529576473e-68 miRanda;mirMAP -2.01793594346917 1.06482309489454e-17 NA NA NA hsa-miR-590-5p FGF9 0.709763558412506 1.11883921359361e-11 -7.89303410861971 6.51626529576473e-68 miRanda -1.77139537220211 2.97618057411205e-10 NA NA NA hsa-miR-106a-5p FGFR1 -0.830908656792615 2.67547872901508e-10 -0.0525238824904433 0.558795583881832 mirMAP -0.122312677751729 0.000796948557217005 NA NA NA hsa-miR-106b-5p FGFR1 1.07509411417907 2.11739194181878e-36 -0.0525238824904433 0.558795583881832 mirMAP -0.172801838537576 0.000867031520570411 NA NA NA hsa-miR-15a-5p FGFR1 1.42663930007845 1.36006952074963e-57 -0.0525238824904433 0.558795583881832 miRNATAP -0.155174390546639 0.0008156091626643 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-5p FGFR1 0.934012514027655 4.85417898318515e-24 -0.0525238824904433 0.558795583881832 miRTarBase;miRNATAP -0.147661895787119 0.00311233392470522 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-200a-5p FGFR1 -1.36295040293874 1.31587720312419e-22 -0.0525238824904433 0.558795583881832 mirMAP -0.11714731259483 0.000383511996434836 NA NA NA hsa-miR-455-5p FGFR1 0.773674551205946 2.12957541541474e-09 -0.0525238824904433 0.558795583881832 miRanda -0.135338346114823 0.000273762518549006 NA NA NA hsa-miR-744-5p FGFR1 -0.348985243196771 0.000187889982228835 -0.0525238824904433 0.558795583881832 miRNAWalker2_validate -0.146388006709524 0.00556141272629985 NA NA NA hsa-miR-93-5p FGFR1 1.37365940377595 2.37567548683245e-46 -0.0525238824904433 0.558795583881832 mirMAP -0.12587058194249 0.00478965048434933 NA NA NA hsa-let-7f-1-3p FGFR2 0.477913872379336 4.46669616865068e-05 -1.51421563934131 8.18226435279308e-18 mirMAP -0.459956632895475 7.61285152724438e-07 NA NA NA hsa-miR-107 FGFR2 0.140046250553248 0.0943611632552367 -1.51421563934131 8.18226435279308e-18 PITA;miRanda -0.437925872253477 0.000383864151891506 NA NA NA hsa-miR-146b-5p FGFR2 1.40714170253819 2.9559871816487e-12 -1.51421563934131 8.18226435279308e-18 miRanda -0.195329005140458 6.1791587336115e-05 NA NA NA hsa-miR-186-5p FGFR2 0.507217561043443 9.04455748270995e-10 -1.51421563934131 8.18226435279308e-18 miRNAWalker2_validate -0.658270917605348 3.90698190892792e-08 NA NA NA hsa-miR-193a-3p FGFR2 0.849206638484406 3.68101781083335e-14 -1.51421563934131 8.18226435279308e-18 miRanda -0.301820482762674 0.000602194355705739 NA NA NA hsa-miR-19b-1-5p FGFR2 0.66692013055553 1.55789130176287e-09 -1.51421563934131 8.18226435279308e-18 miRNAWalker2_validate;miRTarBase -0.282031805724181 0.00192425817708402 NA NA NA hsa-miR-330-5p FGFR2 1.44960468659754 2.12131210588035e-45 -1.51421563934131 8.18226435279308e-18 miRanda -0.664891022598281 1.62616877464583e-15 NA NA NA hsa-miR-338-3p FGFR2 0.906250377628867 2.76970900371139e-15 -1.51421563934131 8.18226435279308e-18 miRanda;miRNATAP -0.293371462535014 0.000601750978017947 NA NA NA hsa-miR-423-3p FGFR2 0.460506077888547 3.44680149368459e-09 -1.51421563934131 8.18226435279308e-18 PITA;miRNATAP -0.489761504946408 0.000152390546115974 NA NA NA hsa-miR-590-3p FGFR2 1.13702599385212 3.53435739887793e-22 -1.51421563934131 8.18226435279308e-18 miRanda -0.563054904471333 1.30676539898336e-12 NA NA NA hsa-miR-100-5p FGFR3 0.11286733449117 0.464055070627288 -0.904654482736578 8.36824652739321e-07 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.313875417771344 2.1395862881888e-06 25344675;26604796;26018508;23778527 MicroRNA 100 regulates pancreatic cancer cells growth and sensitivity to chemotherapy through targeting FGFR3; The predicted target of miR-100 fibroblast growth factor receptor 3 FGFR3 was downregulated by siRNA to examine its effect on pancreatic cancer cells; Luciferase essay showed FGFR3 was direct target of miR-100; FGFR3 was significantly downregulated by overexpressing miR-100 in pancreatic cancer cells and knocking down FGFR3 by siRNA exerted similar effect as miR-100; Our study demonstrated that miR-100 played an important role in pancreatic cancer development possibly through targeting FGFR3;Overexpression of miR 100 inhibits cell proliferation migration and chemosensitivity in human glioblastoma through FGFR3; Expression of fibroblast growth factor receptor 3 FGFR3 the bioinformatically predicted target of miR-100 was examined by Western blot in glioblastoma; FGFR3 was directly regulated by miR-100 in glioblastoma; Ectopically overexpressing FGFR3 was able to ameliorate the anticancer effects of upregulation of miR-100 on glioblastoma growth migration and chemosensitivity; Overexpressing miR-100 had anticancer effects on glioblastoma likely through regulation of FGFR3;Overexpression of miR 100 inhibits growth of osteosarcoma through FGFR3; Here we reported significantly higher levels of fibroblast growth factor receptor 3 FGFR3 and significantly lower levels of miR-100 in the OS specimen compared to those in the paired normal bone tissues; Bioinformatics analysis and luciferase reporter assay suggest that miR-100 binds to the 3'UTR of FGFR3 mRNA to prevent its translation; Taken together our data demonstrate that miR-100 may inhibit the growth of OS through FGFR3;Hypoxia regulates FGFR3 expression via HIF 1α and miR 100 and contributes to cell survival in non muscle invasive bladder cancer; We have previously investigated the role of microRNAs in bladder cancer and have shown that FGFR3 is a target of miR-100; In this study we investigated the effects of hypoxia on miR-100 and FGFR3 expression and the link between miR-100 and FGFR3 in hypoxia; Bladder cancer cell lines were exposed to normoxic or hypoxic conditions and examined for the expression of FGFR3 by quantitative PCR qPCR and western blotting and miR-100 by qPCR; The effect of FGFR3 and miR-100 on cell viability in two-dimensional 2-D and three-dimensional 3-D was examined by transfecting siRNA or mimic-100 respectively; Increased FGFR3 was also in part dependent on miR-100 levels which decreased in hypoxia; Hypoxia in part via suppression of miR-100 induces FGFR3 expression in bladder cancer both of which have an important role in maintaining cell viability under conditions of stress ;;;poor survival pancreatic cancer;glioblastoma;sarcoma;bladder cancer hsa-miR-142-3p FGFR3 1.88928758773299 2.72985643829893e-22 -0.904654482736578 8.36824652739321e-07 miRanda -0.280059637101442 7.39044053762073e-09 NA NA NA hsa-miR-19a-3p FGFR3 0.722913586880779 2.76301458932381e-10 -0.904654482736578 8.36824652739321e-07 mirMAP -0.264260219813925 0.00257802543229013 NA NA NA hsa-miR-590-3p FGFR3 1.13702599385212 3.53435739887793e-22 -0.904654482736578 8.36824652739321e-07 miRanda -0.407978649398992 5.16183297718401e-07 NA NA NA hsa-miR-378a-3p FLNA 0.287244802401236 0.0501155019984562 0.493050812934669 2.00509364955269e-05 miRNAWalker2_validate -0.149269549378477 0.000666251297060202 NA NA NA hsa-miR-155-5p FLNB 3.26274490570809 5.06841441826518e-51 -0.669582920719076 1.73608387359006e-09 miRNAWalker2_validate -0.167121421447989 2.5115576589042e-12 NA NA NA hsa-miR-16-2-3p FLNB 1.3046118743965 4.17207934608428e-19 -0.669582920719076 1.73608387359006e-09 mirMAP -0.212745731662037 1.07820856471299e-07 NA NA NA hsa-miR-193a-3p FLNB 0.849206638484406 3.68101781083335e-14 -0.669582920719076 1.73608387359006e-09 miRanda -0.141455457721811 0.00900455195531357 NA NA NA hsa-miR-22-5p FLNB -0.197038086012602 0.106234828461117 -0.669582920719076 1.73608387359006e-09 mirMAP -0.241223845309208 2.39972520368331e-06 NA NA NA hsa-miR-2355-3p FLNB 1.32757890426926 1.88016636795886e-18 -0.669582920719076 1.73608387359006e-09 mirMAP -0.170659957003205 2.01556094076184e-05 NA NA NA hsa-miR-421 FLNB 0.313155739887734 0.020433534776003 -0.669582920719076 1.73608387359006e-09 mirMAP -0.254599785491755 7.33565701961837e-08 NA NA NA hsa-miR-484 FLNB 0.571987778099603 9.67278224458421e-10 -0.669582920719076 1.73608387359006e-09 miRNAWalker2_validate -0.303576133264391 3.29829671875409e-06 NA NA NA hsa-miR-708-3p FLNB 0.83540388887946 3.55308012540402e-06 -0.669582920719076 1.73608387359006e-09 mirMAP -0.128503872497388 0.000172872520710635 NA NA NA hsa-miR-142-5p FOS 1.88417391525707 1.2096808039882e-27 -0.974446999749473 5.66907745776034e-06 PITA -0.178117621561725 0.00518382638888386 NA NA NA hsa-miR-155-5p FOS 3.26274490570809 5.06841441826518e-51 -0.974446999749473 5.66907745776034e-06 MirTarget -0.150038301184289 0.00139777456314595 23693020 Also S100P treatment stimulated the enrichment of c-Fos an AP-1 family member at the miR-155 host gene promoter site colon cancer hsa-miR-181b-5p FOS 1.49054296272357 3.69051660739368e-41 -0.974446999749473 5.66907745776034e-06 miRNATAP -0.271347246896234 0.0044547557143666 NA NA NA hsa-miR-221-3p FOS 0.337895669520713 0.0136448974691037 -0.974446999749473 5.66907745776034e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.233290497803943 0.00778137250101478 NA NA NA hsa-miR-590-3p FOS 1.13702599385212 3.53435739887793e-22 -0.974446999749473 5.66907745776034e-06 miRanda -0.282414279240017 0.00325837380552156 NA NA NA hsa-miR-130b-3p GADD45A 1.12788913578446 2.939369462276e-16 -0.71804270155153 2.2880912615879e-10 MirTarget;miRNATAP -0.192802325941396 1.24534330083127e-05 NA NA NA hsa-miR-146b-5p GADD45A 1.40714170253819 2.9559871816487e-12 -0.71804270155153 2.2880912615879e-10 miRanda -0.121731151301817 6.74215575167157e-05 NA NA NA hsa-miR-301a-3p GADD45A 0.259400847075798 0.0216890736701418 -0.71804270155153 2.2880912615879e-10 MirTarget;miRNATAP -0.161714923757434 0.00452184693981742 NA NA NA hsa-miR-361-3p GADD45A 1.08992546227594 1.13197240706704e-36 -0.71804270155153 2.2880912615879e-10 MirTarget -0.218642571070405 0.00105969438528677 NA NA NA hsa-miR-454-3p GADD45A 0.68285296887698 1.17407812677787e-08 -0.71804270155153 2.2880912615879e-10 MirTarget;miRNATAP -0.236333328240283 5.72279489466588e-06 NA NA NA hsa-miR-590-3p GADD45A 1.13702599385212 3.53435739887793e-22 -0.71804270155153 2.2880912615879e-10 miRanda;mirMAP -0.217410143684049 1.97603197692947e-05 NA NA NA hsa-miR-140-5p GADD45B 0.504309496243674 3.09884038729031e-11 -0.441816165211003 0.00276475211524877 miRanda -0.283153773830058 0.00746764408150905 NA NA NA hsa-miR-1976 GADD45B 0.343475600930938 0.000360243844871748 -0.441816165211003 0.00276475211524877 miRNATAP -0.307872195722378 0.000272522224222968 NA NA NA hsa-miR-324-3p GADD45B -0.197662887871899 0.0298845059559819 -0.441816165211003 0.00276475211524877 MirTarget;miRNATAP -0.247089916093826 0.00645517764784922 NA NA NA hsa-miR-181a-5p GADD45G 1.11111114875339 3.97880443756442e-29 -0.695169717761439 6.17291350390005e-05 miRNAWalker2_validate -0.308928800063779 0.00053609177523059 NA NA NA hsa-miR-1976 GADD45G 0.343475600930938 0.000360243844871748 -0.695169717761439 6.17291350390005e-05 MirTarget -0.324215450846578 0.00121322985194693 NA NA NA hsa-miR-320a GADD45G 0.412740558379182 2.02929519701706e-05 -0.695169717761439 6.17291350390005e-05 miRanda -0.461886062957496 2.61555335659708e-06 NA NA NA hsa-miR-200a-3p GNA12 -1.43409013664263 2.00188483717828e-20 0.209521247624396 0.000372562099180893 mirMAP -0.137905513266175 5.27609966806225e-13 NA NA NA hsa-miR-23b-3p GNA12 -0.533749586990474 2.46924776953771e-10 0.209521247624396 0.000372562099180893 miRNAWalker2_validate -0.165548753091661 1.03798541047073e-05 NA NA NA hsa-miR-30a-3p GNA12 -0.955360819934585 1.97009535429185e-20 0.209521247624396 0.000372562099180893 MirTarget -0.259340704924112 2.86694175785722e-20 NA NA NA hsa-miR-30d-3p GNA12 -0.249777194282131 0.00235356711813496 0.209521247624396 0.000372562099180893 MirTarget -0.21001252524179 8.70503892446178e-08 NA NA NA hsa-miR-30e-3p GNA12 -0.205602546270795 0.00132666419729688 0.209521247624396 0.000372562099180893 MirTarget -0.209999992994173 4.13369706317713e-05 NA NA NA hsa-miR-28-5p GNG12 0.461962042257226 3.32424690573327e-11 -0.585710433799246 5.64727247192656e-14 PITA;miRanda -0.213018744184183 0.000716637360164746 NA NA NA hsa-miR-455-5p GNG12 0.773674551205946 2.12957541541474e-09 -0.585710433799246 5.64727247192656e-14 miRanda -0.104628790500717 0.00192421839743675 NA NA NA hsa-miR-590-3p GNG12 1.13702599385212 3.53435739887793e-22 -0.585710433799246 5.64727247192656e-14 miRanda;mirMAP -0.166394460792321 2.45843912730583e-06 NA NA NA hsa-miR-590-5p GNG12 0.709763558412506 1.11883921359361e-11 -0.585710433799246 5.64727247192656e-14 PITA -0.136601828608981 0.000985486999487911 NA NA NA hsa-miR-146b-5p HSPA1A 1.40714170253819 2.9559871816487e-12 -0.64020574662548 4.33050315595494e-08 miRanda -0.100774220930939 0.00134241336925839 NA NA NA hsa-miR-15a-5p HSPA1A 1.42663930007845 1.36006952074963e-57 -0.64020574662548 4.33050315595494e-08 miRNAWalker2_validate -0.200521356105979 0.00117605579321497 NA NA NA hsa-miR-34a-5p HSPA1A 1.07544567720768 1.81510842038009e-20 -0.64020574662548 4.33050315595494e-08 miRNAWalker2_validate -0.144630862685635 0.00686125011632478 NA NA NA hsa-let-7b-5p HSPA1B 0.770868211539597 6.63408323707647e-21 -0.833325945205365 1.80868823915778e-11 miRNAWalker2_validate -0.372621996124776 3.72857263477259e-06 NA NA NA hsa-miR-106b-5p HSPA1B 1.07509411417907 2.11739194181878e-36 -0.833325945205365 1.80868823915778e-11 miRNAWalker2_validate -0.194229002060567 0.00907453619789648 NA NA NA hsa-miR-142-3p HSPA1B 1.88928758773299 2.72985643829893e-22 -0.833325945205365 1.80868823915778e-11 miRanda -0.118060996443274 0.000467619628931651 NA NA NA hsa-miR-16-5p HSPA1B 0.934012514027655 4.85417898318515e-24 -0.833325945205365 1.80868823915778e-11 miRNAWalker2_validate -0.197732319488363 0.00567109471981271 NA NA NA hsa-miR-25-3p HSPA1B 1.12016166564779 3.79069348635778e-48 -0.833325945205365 1.80868823915778e-11 miRNAWalker2_validate -0.340980401584586 1.61373694573659e-05 NA NA NA hsa-miR-330-5p HSPA1B 1.44960468659754 2.12131210588035e-45 -0.833325945205365 1.80868823915778e-11 miRNAWalker2_validate -0.303416294141616 2.83631323022372e-07 NA NA NA hsa-miR-34a-5p HSPA1B 1.07544567720768 1.81510842038009e-20 -0.833325945205365 1.80868823915778e-11 miRNAWalker2_validate -0.173728327720376 0.00244224025389069 NA NA NA hsa-miR-192-5p HSPA2 0.442478872410106 0.0669238175123954 -3.67641428358631 4.69927752496419e-71 miRNAWalker2_validate -0.430059967456078 2.81889223673421e-14 NA NA NA hsa-miR-215-5p HSPA2 1.57223951497888 6.18833867819653e-10 -3.67641428358631 4.69927752496419e-71 miRNAWalker2_validate -0.527088253068363 1.54074679364143e-25 NA NA NA hsa-miR-339-5p HSPA2 0.322848334531193 0.0117281778821612 -3.67641428358631 4.69927752496419e-71 miRanda -0.392762156968417 0.000380506294064636 NA NA NA hsa-miR-7-1-3p HSPA2 0.544601828025304 5.33830451326047e-07 -3.67641428358631 4.69927752496419e-71 mirMAP -0.718318540789555 1.51003460665391e-08 NA NA NA hsa-let-7b-5p HSPA8 0.770868211539597 6.63408323707647e-21 -0.818981584693764 5.40286607104388e-17 miRNAWalker2_validate -0.18834015253947 0.00392616884756114 NA NA NA hsa-miR-15b-5p HSPA8 0.773001494057531 1.71784656078957e-16 -0.818981584693764 5.40286607104388e-17 miRNAWalker2_validate -0.166810512647989 0.00396522804331029 NA NA NA hsa-miR-17-5p HSPA8 0.494260110870015 3.8348005261e-09 -0.818981584693764 5.40286607104388e-17 TargetScan -0.220220339025369 0.000916405636567628 NA NA NA hsa-miR-25-3p HSPA8 1.12016166564779 3.79069348635778e-48 -0.818981584693764 5.40286607104388e-17 miRNAWalker2_validate -0.278294299840686 1.14708384309286e-05 NA NA NA hsa-miR-320a HSPA8 0.412740558379182 2.02929519701706e-05 -0.818981584693764 5.40286607104388e-17 miRNAWalker2_validate -0.264784017410284 4.34559868702962e-06 NA NA NA hsa-miR-590-3p HSPA8 1.13702599385212 3.53435739887793e-22 -0.818981584693764 5.40286607104388e-17 PITA;miRanda -0.168019347021754 0.000195013238210649 NA NA NA hsa-miR-125a-5p IKBKG -0.561874059994802 7.3931856356891e-13 0.49642799282577 6.30392568162462e-12 miRanda -0.278136800860417 3.13020186123498e-08 NA NA NA hsa-miR-30d-3p IL1B -0.249777194282131 0.00235356711813496 0.452671620711598 0.021616046645869 MirTarget -0.351984998077896 0.0084154714072512 NA NA NA hsa-miR-17-3p IL1R1 0.723795600017259 5.90151677164931e-18 -0.474344231843599 4.16095974966973e-06 mirMAP -0.29448640551499 6.02783377610477e-06 NA NA NA hsa-miR-181a-5p IL1R1 1.11111114875339 3.97880443756442e-29 -0.474344231843599 4.16095974966973e-06 mirMAP -0.181663741757188 0.000629221572221257 NA NA NA hsa-miR-181b-5p IL1R1 1.49054296272357 3.69051660739368e-41 -0.474344231843599 4.16095974966973e-06 mirMAP -0.146779912464916 0.00130558816294013 NA NA NA hsa-miR-30a-3p IL1R1 -0.955360819934585 1.97009535429185e-20 -0.474344231843599 4.16095974966973e-06 mirMAP -0.203431063888192 0.000104910058488366 NA NA NA hsa-miR-30d-3p IL1R1 -0.249777194282131 0.00235356711813496 -0.474344231843599 4.16095974966973e-06 mirMAP -0.291676436549261 3.11895527929566e-05 NA NA NA hsa-miR-30e-3p IL1R1 -0.205602546270795 0.00132666419729688 -0.474344231843599 4.16095974966973e-06 mirMAP -0.321019827583332 0.000415299430775297 NA NA NA hsa-miR-940 JMJD7-PLA2G4B -0.160421460715008 0.279016637176929 0.151094662027853 0.188937979716058 miRNATAP -0.163357602541697 0.000249936751053691 NA NA NA hsa-miR-30a-5p JUN -0.778411951775343 2.73322451127932e-16 0.299129375328292 0.0179949924502712 miRNAWalker2_validate -0.220689109507382 0.00170903222537552 NA NA NA hsa-miR-186-5p JUND 0.507217561043443 9.04455748270995e-10 -0.194035034983125 0.0824745285106373 miRNAWalker2_validate -0.225236304088478 0.00206580824914203 NA NA NA hsa-miR-589-3p JUND -0.0184909376114044 0.903149951095234 -0.194035034983125 0.0824745285106373 MirTarget -0.113481999445318 0.00617468250857643 NA NA NA hsa-let-7a-3p KRAS 0.0677487960013088 0.460458477653989 -0.255817061539648 9.1459633191595e-05 mirMAP;miRNATAP -0.135776810220158 0.000642882403233645 24727325;20603437;24890702;23324806;21994416;23167843;27620744;20177422;25183481;22584434;18922928 Association study of the let 7 miRNA complementary site variant in the 3' untranslated region of the KRAS gene in stage III colon cancer NCCTG N0147 Clinical Trial; A let-7 microRNA-complementary site LCS6 polymorphism in the 3' untranslated region of the KRAS gene has been shown to disrupt let-7 binding and upregulate KRAS expression;A let 7 microRNA binding site polymorphism in 3' untranslated region of KRAS gene predicts response in wild type KRAS patients with metastatic colorectal cancer treated with cetuximab monotherapy; A polymorphism in a let-7 microRNA complementary site lcs6 in the KRAS 3' untranslated region UTR is associated with an increased cancer risk in non-small-cell lung cancer and reduced overall survival OS in oral cancers; the presence of KRAS let-7 lcs6 polymorphism was evaluated in 130 mCRC patients who were enrolled in a phase II study of cetuximab monotherapy IMCL-0144; KRAS let-7 lcs6 polymorphism was found to be related to object response rate ORR in mCRC patients whose tumors had KRASwt;Let 7 microRNA binding site polymorphism in the 3'UTR of KRAS and colorectal cancer outcome: a systematic review and meta analysis; There is a small but growing body of literature regarding the predictive utility of a Let-7 microRNA-binding-site polymorphism in the 3'-untranslated region UTR of KRAS KRAS-LCS6 for colorectal cancer outcome although the results are conflicting; A PubMed search was conducted to identify all studies reporting on KRAS let-7 microRNA-binding site polymorphism LCS6; rs61764370 and colorectal cancer outcome;The LCS6 polymorphism in the binding site of let 7 microRNA to the KRAS 3' untranslated region: its role in the efficacy of anti EGFR based therapy in metastatic colorectal cancer patients; The lethal-7 let-7 family of microRNAs regulates KRAS activity; We studied the association of the KRAS let-7 LCS6 polymorphism with the response in 100 refractory mCRC patients treated with anti-EGFR antibodies; The KRAS let-7 LCS6 polymorphism was genotyped using the BioMark system in blood and tumor DNA samples; The KRAS let-7 LCS6 G-allele showed a statistically significant association with nonresponse to anti-EGFR-based treatment: 31.9% of patients with the T/T genotype presented a complete or a partial response versus no patients with T/G or G/G genotypes P=0.004;A let 7 microRNA SNP in the KRAS 3'UTR is prognostic in early stage colorectal cancer; Recently a SNP in a lethal-7 let-7 miRNA complementary site LCS6 in the KRAS 3'untranslated region was suggested to affect survival in metastatic CRC;Let 7 miRNA binding site polymorphism in the KRAS 3'UTR; colorectal cancer screening population prevalence and influence on clinical outcome in patients with metastatic colorectal cancer treated with 5 fluorouracil and oxaliplatin +/ cetuximab; Recent studies have reported associations between a variant allele in a let-7 microRNA complementary site LCS6 within the 3'untranslated region 3'UTR of KRAS rs61764370 and clinical outcome in metastatic colorectal cancer mCRC patients receiving cetuximab;A let 7 microRNA binding site polymorphism in the KRAS 3'UTR is associated with increased risk and reduced survival for gallbladder cancer in North Indian population; The let-7 microRNAs play a key role in regulating KRAS expression and a polymorphism in 3' untranslated region rs61764370 T/G of KRAS leads to its higher expression;Genetic modulation of the Let 7 microRNA binding to KRAS 3' untranslated region and survival of metastatic colorectal cancer patients treated with salvage cetuximab irinotecan; There is increasing evidence that the Let-7 microRNA miRNA exerts an effect as a tumor suppressor by targeting the KRAS mRNA; The Let-7 complementary site LCS6 T>G variant in the KRAS 3'-untranslated region weakens Let-7 binding;A let 7 microRNA binding site polymorphism in KRAS predicts improved outcome in patients with metastatic colorectal cancer treated with salvage cetuximab/panitumumab monotherapy;High let 7a microRNA levels in KRAS mutated colorectal carcinomas may rescue anti EGFR therapy effects in patients with chemotherapy refractory metastatic disease; Preclinical and experimental data in vivo indicate that Lethal-7 Let-7 microRNA downregulates KRAS with antitumor effects in the presence of activating KRAS mutations; In 59 patients harboring KRAS mutations Let-7a levels were analyzed for association with overall survival OS and progression-free survival PFS times; An exploratory subgroup analysis was performed using the rs61764370 LCS6 T>G polymorphism that experimentally impairs Let-7 binding to KRAS mRNA; In patients with KRAS mutations Let-7a analysis may serve to identify subgroups of patients who may still benefit from EGFR inhibition and this may open up new perspectives for alternative treatment strategies;A SNP in a let 7 microRNA complementary site in the KRAS 3' untranslated region increases non small cell lung cancer risk; The purpose of this study was to identify single nucleotide polymorphisms SNP that could modify let-7 binding and to assess the effect of such SNPs on target gene regulation and risk for non-small cell lung cancer NSCLC let-7 complementary sites LCS were sequenced in the KRAS 3' untranslated region from 74 NSCLC cases to identify mutations and SNPs that correlated with NSCLC; The LCS6 variant allele in a KRAS miRANA complementary site is significantly associated with increased risk for NSCLC among moderate smokers and represents a new paradigm for let-7 miRNAs in lung cancer susceptibility staging;drug resistance;poor survival;;drug resistance;staging;poor survival;;poor survival;poor survival;;progression;poor survival; colon cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;bladder cancer;colorectal cancer;colorectal cancer;colorectal cancer;lung squamous cell cancer hsa-miR-140-3p KRAS 0.989350547007025 6.14964028267239e-25 -0.255817061539648 9.1459633191595e-05 MirTarget -0.108294077444579 0.00207293957432564 NA NA NA hsa-miR-193a-3p KRAS 0.849206638484406 3.68101781083335e-14 -0.255817061539648 9.1459633191595e-05 MirTarget;miRanda;miRNATAP -0.128321272108433 3.45488258543067e-05 NA NA NA hsa-miR-193a-5p KRAS 1.29777740059595 2.16815694068336e-39 -0.255817061539648 9.1459633191595e-05 miRNATAP -0.131260938035955 4.98455580646047e-05 NA NA NA hsa-miR-27a-3p KRAS 0.558934437526245 1.44256383086177e-12 -0.255817061539648 9.1459633191595e-05 miRNATAP -0.185157688434118 3.18082458260436e-05 24154848;25436011 microRNA 27a functions as a tumor suppressor in esophageal squamous cell carcinoma by targeting KRAS; Furthermore we demonstrated that miR-27a binds to the 3'-untranslated region UTR of KRAS and inhibits the expression of the KRAS protein; miR-27a levels were inversely correlated with levels of KRAS mRNA and protein in ESCC specimens; Our findings suggest for the first time that miR-27a suppresses tumorigenesis of ESCC by targeting KRAS;MicroRNA 27a directly targets KRAS to inhibit cell proliferation in esophageal squamous cell carcinoma; However the expression level of the target gene KRAS was upregulated and ESCC cell proliferation was significantly inhibited following miR-27a mimic or small interfering K-ras transfection; In conclusion the present study demonstrated that the expression level of miR-27a was low in ESCC and that miR-27a directly targets the KRAS gene resulting in inhibited cell proliferation in esophageal cancer tumorigenesis; esophageal cancer;esophageal cancer hsa-miR-542-3p KRAS 0.431147917094433 0.000254981247606435 -0.255817061539648 9.1459633191595e-05 miRanda -0.102463772502373 0.00079256513841055 NA NA NA hsa-miR-25-3p MAP2K4 1.12016166564779 3.79069348635778e-48 -0.256111529919685 1.19532429297845e-07 miRNATAP -0.15637315325387 1.88463023072568e-07 NA NA NA hsa-miR-27a-3p MAP2K4 0.558934437526245 1.44256383086177e-12 -0.256111529919685 1.19532429297845e-07 miRNATAP -0.180828613537995 3.45310093690847e-08 27594411;24556602 Androgen induced miR 27A acted as a tumor suppressor by targeting MAP2K4 and mediated prostate cancer progression;MicroRNA 27a promotes proliferation migration and invasion by targeting MAP2K4 in human osteosarcoma cells; In this study three biological programs were used to predict whether MAP2K4 was a target of miR-27a; Thus MAP2K4 is a potential target of miR-27a and can be directly regulated by miR-27a; After transfection of the miR-27a inhibitor into the MG63 cells the level of phospho-JNK1 and phospho-p38 increased by 25% and 29% respectively along with the up-regulation of MAP2K4 protein; This is the first study showing that miR-27a can function as an oncogene by targeting MAP2K4 in the osteosarcoma MG63 cell line; Inhibition of miR-27a increases MAP2K4 expression which in turn inhibits cell proliferation and migration through the JNK/p38 signaling pathway in MG63 cells progression; prostate cancer;sarcoma hsa-miR-92a-3p MAP2K4 0.178194888895831 0.0088835082650834 -0.256111529919685 1.19532429297845e-07 miRNATAP -0.11013137941053 0.00616391800414065 NA NA NA hsa-miR-342-3p MAP2K6 1.4124432570595 1.07208971556131e-28 -0.695630422742668 1.72641616875695e-12 miRanda -0.109985928803232 0.00675294799829099 NA NA NA hsa-miR-374a-5p MAP2K6 0.543061152108237 2.19403097299769e-14 -0.695630422742668 1.72641616875695e-12 MirTarget -0.219755553305824 0.00434501503544195 NA NA NA hsa-miR-590-3p MAP2K6 1.13702599385212 3.53435739887793e-22 -0.695630422742668 1.72641616875695e-12 miRanda -0.179629026820449 5.9131776024203e-05 NA NA NA hsa-miR-125a-5p MAP2K7 -0.561874059994802 7.3931856356891e-13 0.316094522329282 1.50617688805415e-07 miRNAWalker2_validate;PITA;miRanda;miRNATAP -0.119125963452203 0.0044661201240712 NA NA NA hsa-let-7i-5p MAP3K1 0.911372377723717 7.11483853341932e-31 -0.487131033823081 1.2688411385358e-08 miRNATAP -0.196043909449054 0.000448162305959391 NA NA NA hsa-miR-106b-5p MAP3K1 1.07509411417907 2.11739194181878e-36 -0.487131033823081 1.2688411385358e-08 miRNATAP -0.339365554394447 5.67573804750805e-12 NA NA NA hsa-miR-18a-5p MAP3K1 0.936704393213466 1.05064580570579e-10 -0.487131033823081 1.2688411385358e-08 miRNATAP -0.163443412739824 2.8788448227482e-07 NA NA NA hsa-miR-193a-3p MAP3K1 0.849206638484406 3.68101781083335e-14 -0.487131033823081 1.2688411385358e-08 PITA;miRanda -0.153819817096251 0.000195253844400114 NA NA NA hsa-miR-21-5p MAP3K1 2.51462371613332 3.30620591950316e-66 -0.487131033823081 1.2688411385358e-08 miRNAWalker2_validate -0.143107258105376 5.66741424922186e-08 NA NA NA hsa-miR-23a-3p MAP3K1 0.761438723382355 4.09310879199257e-27 -0.487131033823081 1.2688411385358e-08 miRNATAP -0.193247476855467 0.00236166325699634 NA NA NA hsa-miR-26b-5p MAP3K1 -0.251437253429904 0.00270935785098697 -0.487131033823081 1.2688411385358e-08 miRNATAP -0.153989552819669 0.00777650080781727 NA NA NA hsa-miR-339-5p MAP3K1 0.322848334531193 0.0117281778821612 -0.487131033823081 1.2688411385358e-08 miRanda -0.122674290211546 0.00108166176793396 NA NA NA hsa-miR-342-3p MAP3K1 1.4124432570595 1.07208971556131e-28 -0.487131033823081 1.2688411385358e-08 miRanda -0.158348740222488 4.16152497117428e-06 NA NA NA hsa-miR-34a-5p MAP3K1 1.07544567720768 1.81510842038009e-20 -0.487131033823081 1.2688411385358e-08 miRNAWalker2_validate -0.110162605565508 0.00492621267294008 NA NA NA hsa-miR-421 MAP3K1 0.313155739887734 0.020433534776003 -0.487131033823081 1.2688411385358e-08 miRanda -0.126382486849297 0.000581454820917654 NA NA NA hsa-miR-590-3p MAP3K1 1.13702599385212 3.53435739887793e-22 -0.487131033823081 1.2688411385358e-08 PITA;miRanda;mirMAP -0.192119509830085 4.35600462259978e-07 NA NA NA hsa-miR-590-5p MAP3K1 0.709763558412506 1.11883921359361e-11 -0.487131033823081 1.2688411385358e-08 PITA;miRanda;miRNATAP -0.224622763267165 3.83863864286806e-07 NA NA NA hsa-miR-616-5p MAP3K1 0.913426384742148 3.78418389333709e-09 -0.487131033823081 1.2688411385358e-08 miRNATAP -0.106621341105123 0.000531844771988709 NA NA NA hsa-miR-93-5p MAP3K1 1.37365940377595 2.37567548683245e-46 -0.487131033823081 1.2688411385358e-08 miRNATAP -0.120122654782916 0.00583925002065958 NA NA NA hsa-miR-106a-5p MAP3K11 -0.830908656792615 2.67547872901508e-10 0.760076784639225 2.54303177552805e-19 miRNATAP -0.139343290978966 0.000127825084255193 NA NA NA hsa-miR-125a-5p MAP3K11 -0.561874059994802 7.3931856356891e-13 0.760076784639225 2.54303177552805e-19 PITA;miRanda;miRNATAP -0.260296024304582 1.96882505292976e-05 NA NA NA hsa-miR-125b-5p MAP3K11 -0.825456421494266 2.13029877878434e-15 0.760076784639225 2.54303177552805e-19 miRNATAP -0.191389403456484 2.32529839559508e-05 24635082 Expression of the miRNA miR-125b and serine/threonine kinase mixed lineage kinase MLK3 was assessed in primary malignant melanoma tissues and several melanoma cell lines by quantitative reverse transcription PCR; The effect of MLK3 and miR-125b on cell proliferation was evaluated by MTS assay and cell invasion was evaluated by Transwell invasion assays; Targeting of MLK3 by miR-125b was evaluated using luciferase reporter assay and western blotting; Using bioinformatics we identified MLK3 as one potential target of miR-125b; miRNA transfection and luciferase assay confirmed that MLK3 was regulated by miR-125b at both the transcriptional and translational levels; MLK3 is a direct target of miR-125b malignant trasformation melanoma hsa-miR-199a-5p MAP3K11 -1.64658415208633 1.01615659358973e-23 0.760076784639225 2.54303177552805e-19 miRNAWalker2_validate;miRTarBase;PITA;miRanda;miRNATAP -0.114642496487847 3.70246017169146e-05 26717044;26885275 Overexpression of miR 199a 5p decreases esophageal cancer cell proliferation through repression of mitogen activated protein kinase kinase kinase 11 MAP3K11; MiR-199a-5p is predicted to bind mitogen-activated protein kinase kinase kinase 11 MAP3K11 mRNA with high affinity; Forced expression of miR-199a-5p in these cells leads to a decrease in the mRNA and protein levels of MAP3K11 due to decreased MAP3K11 mRNA stability; A direct binding interaction between miR-199a-5p and MAP3K11 mRNA is demonstrated using biotin pull-down assays and heterologous luciferase reporter constructs and confirmed by mutational analysis; These findings suggest that miR-199a-5p acts as a tumor suppressor in esophageal cancer cells and that its downregulation contributes to enhanced cellular proliferation by targeting MAP3K11;Further investigation reported that MLK3 was a direct target of miR-199a-5p; Moreover the expression level of miR-199a-5p was conversely correlated with MLK3 in bladder cancerous cells; In addition reintroduction of MLK3 was identified to promote the proliferation and inhibit the apoptotic rate of cells which have been altered by miR-199a-5p through activating the NF-κB pathway ; esophageal cancer;bladder cancer hsa-miR-20b-5p MAP3K11 -1.30218163823367 6.87172815978149e-17 0.760076784639225 2.54303177552805e-19 miRNATAP -0.160678791709719 6.17544987689337e-08 NA NA NA hsa-miR-106a-5p MAP3K12 -0.830908656792615 2.67547872901508e-10 1.04442324340402 3.61490977218789e-21 MirTarget -0.13365723765839 0.00553401964484034 NA NA NA hsa-miR-191-5p MAP3K12 -0.263975812132028 0.0050298924515329 1.04442324340402 3.61490977218789e-21 MirTarget -0.22347161266944 0.00124877540292679 NA NA NA hsa-miR-199a-5p MAP3K12 -1.64658415208633 1.01615659358973e-23 1.04442324340402 3.61490977218789e-21 miRanda;miRNATAP -0.106405064934857 0.00388771602603431 NA NA NA hsa-miR-20b-5p MAP3K12 -1.30218163823367 6.87172815978149e-17 1.04442324340402 3.61490977218789e-21 MirTarget -0.207591834283613 1.12983141066262e-07 NA NA NA hsa-miR-27b-3p MAP3K12 -0.699527231242518 1.07356023759234e-15 1.04442324340402 3.61490977218789e-21 miRNATAP -0.428328127811245 1.05513783587023e-09 NA NA NA hsa-miR-30a-5p MAP3K12 -0.778411951775343 2.73322451127932e-16 1.04442324340402 3.61490977218789e-21 MirTarget -0.470625854197693 1.02861049908265e-13 NA NA NA hsa-miR-30b-5p MAP3K12 -1.18330589477119 6.8341618466966e-27 1.04442324340402 3.61490977218789e-21 MirTarget -0.261758985090107 1.1646551724999e-06 NA NA NA hsa-miR-30c-5p MAP3K12 -1.08783070774238 2.02505402525786e-24 1.04442324340402 3.61490977218789e-21 MirTarget -0.378426179121637 6.64245901787797e-12 NA NA NA hsa-miR-30d-5p MAP3K12 -0.202727675788184 0.00659067084745794 1.04442324340402 3.61490977218789e-21 MirTarget -0.244130832293133 0.00560203557678898 NA NA NA hsa-miR-30e-5p MAP3K12 -0.0905907245198101 0.21196704484334 1.04442324340402 3.61490977218789e-21 MirTarget -0.620499548130932 2.06505455647933e-12 NA NA NA hsa-miR-324-3p MAP3K12 -0.197662887871899 0.0298845059559819 1.04442324340402 3.61490977218789e-21 MirTarget -0.263287404637376 0.000245101812959162 NA NA NA hsa-miR-429 MAP3K12 -2.16569233119434 2.66862243626443e-37 1.04442324340402 3.61490977218789e-21 miRNATAP -0.252729806822022 1.23291538072072e-14 NA NA NA hsa-miR-577 MAP3K12 -1.48881999472397 7.03080165111147e-10 1.04442324340402 3.61490977218789e-21 PITA -0.169949279598448 3.22760051768616e-11 NA NA NA hsa-miR-615-3p MAP3K12 -0.777370544471479 2.08193713560545e-08 1.04442324340402 3.61490977218789e-21 miRNATAP -0.138370958815344 0.00258200018751763 NA NA NA hsa-miR-671-3p MAP3K12 -0.118856749340912 0.414450889866758 1.04442324340402 3.61490977218789e-21 PITA -0.123530228671879 0.00842117683609931 NA NA NA hsa-miR-125b-5p MAP3K13 -0.825456421494266 2.13029877878434e-15 0.209933658790665 0.137301360590936 miRNATAP -0.342725505325529 1.41324899898414e-06 NA NA NA hsa-miR-130b-5p MAP3K13 0.92990617673277 3.75880436852717e-12 0.209933658790665 0.137301360590936 miRNATAP -0.156390741769799 0.00548692807578247 NA NA NA hsa-miR-149-5p MAP3K13 -1.95790336710741 8.46371715052367e-27 0.209933658790665 0.137301360590936 MirTarget -0.22709405877524 3.56412418918576e-09 NA NA NA hsa-miR-182-5p MAP3K13 -0.608710746044567 0.0025264935278104 0.209933658790665 0.137301360590936 mirMAP -0.100369220575898 0.00903098109717997 NA NA NA hsa-miR-183-5p MAP3K13 -1.21596931064487 1.31473205758898e-08 0.209933658790665 0.137301360590936 MirTarget;miRNATAP -0.100768471482234 0.00458513376341543 NA NA NA hsa-miR-22-5p MAP3K13 -0.197038086012602 0.106234828461117 0.209933658790665 0.137301360590936 mirMAP -0.222274993501971 0.000498709117390967 NA NA NA hsa-miR-24-3p MAP3K13 0.173813044685099 0.00565259443420961 0.209933658790665 0.137301360590936 MirTarget -0.553704519181937 9.64028903363571e-06 NA NA NA hsa-miR-27a-3p MAP3K13 0.558934437526245 1.44256383086177e-12 0.209933658790665 0.137301360590936 MirTarget -0.315158910763021 0.00103721821157912 NA NA NA hsa-miR-335-3p MAP3K13 -1.36498175550207 6.84287752180534e-13 0.209933658790665 0.137301360590936 mirMAP -0.106412057154587 0.00714651959303697 NA NA NA hsa-miR-339-5p MAP3K13 0.322848334531193 0.0117281778821612 0.209933658790665 0.137301360590936 miRanda -0.196055269709781 0.00122880699791909 NA NA NA hsa-miR-33a-5p MAP3K13 -1.59840463890997 1.13487952314403e-18 0.209933658790665 0.137301360590936 MirTarget -0.173402395354279 1.85536574131446e-05 NA NA NA hsa-miR-3913-5p MAP3K13 0.136365354811444 0.24239516424369 0.209933658790665 0.137301360590936 mirMAP -0.248874778597468 0.000395277869859954 NA NA NA hsa-miR-106a-5p MAP3K14 -0.830908656792615 2.67547872901508e-10 1.45318720445739 1.17584767098145e-30 MirTarget -0.260935740592544 3.40016905381867e-06 NA NA NA hsa-miR-20b-5p MAP3K14 -1.30218163823367 6.87172815978149e-17 1.45318720445739 1.17584767098145e-30 MirTarget -0.279425559529384 1.05548734889612e-09 NA NA NA hsa-miR-345-5p MAP3K14 -0.953479075875024 8.95459389953487e-14 1.45318720445739 1.17584767098145e-30 MirTarget -0.245817055552042 1.76279569036036e-05 NA NA NA hsa-miR-362-3p MAP3K14 -0.753214251798232 3.0025661608035e-07 1.45318720445739 1.17584767098145e-30 miRanda -0.169925700987714 0.00129039879476894 NA NA NA hsa-miR-429 MAP3K14 -2.16569233119434 2.66862243626443e-37 1.45318720445739 1.17584767098145e-30 miRNATAP -0.225255564123646 1.08811226987523e-08 NA NA NA hsa-miR-874-3p MAP3K14 -1.50243370621573 8.39418307315909e-25 1.45318720445739 1.17584767098145e-30 MirTarget -0.489327006006763 7.56144334910118e-28 NA NA NA hsa-miR-106b-5p MAP3K2 1.07509411417907 2.11739194181878e-36 -0.162416139107452 0.102046585126356 MirTarget;miRNATAP -0.267854730856697 2.63322355509647e-06 NA NA NA hsa-miR-181b-5p MAP3K2 1.49054296272357 3.69051660739368e-41 -0.162416139107452 0.102046585126356 mirMAP -0.113020492074016 0.00938328478474094 NA NA NA hsa-miR-181c-5p MAP3K2 0.762784646696248 4.48373118147729e-10 -0.162416139107452 0.102046585126356 mirMAP -0.135437779353472 0.00188963502421459 NA NA NA hsa-miR-19b-3p MAP3K2 0.195940928879427 0.0300512922542325 -0.162416139107452 0.102046585126356 MirTarget;mirMAP;miRNATAP -0.166381852671244 0.00640894735575749 NA NA NA hsa-miR-22-5p MAP3K2 -0.197038086012602 0.106234828461117 -0.162416139107452 0.102046585126356 MirTarget -0.138963505386906 0.00198782209984535 NA NA NA hsa-miR-26a-5p MAP3K2 -0.202091714279613 0.00166918288801054 -0.162416139107452 0.102046585126356 miRNAWalker2_validate;miRTarBase;mirMAP;miRNATAP -0.317170824293383 0.000227049628751462 NA NA NA hsa-miR-26b-5p MAP3K2 -0.251437253429904 0.00270935785098697 -0.162416139107452 0.102046585126356 mirMAP;miRNATAP -0.191684117371812 0.00347906177348765 NA NA NA hsa-miR-27a-3p MAP3K2 0.558934437526245 1.44256383086177e-12 -0.162416139107452 0.102046585126356 miRNATAP -0.320239401075758 1.6774119671258e-06 NA NA NA hsa-miR-27b-3p MAP3K2 -0.699527231242518 1.07356023759234e-15 -0.162416139107452 0.102046585126356 miRNATAP -0.197677677665725 0.00103727772942792 NA NA NA hsa-miR-28-5p MAP3K2 0.461962042257226 3.32424690573327e-11 -0.162416139107452 0.102046585126356 miRanda -0.229716235378459 0.00296317903095935 NA NA NA hsa-miR-30b-5p MAP3K2 -1.18330589477119 6.8341618466966e-27 -0.162416139107452 0.102046585126356 mirMAP;miRNATAP -0.168648933586495 0.000219667153538355 NA NA NA hsa-miR-455-5p MAP3K2 0.773674551205946 2.12957541541474e-09 -0.162416139107452 0.102046585126356 miRNATAP -0.117754174544957 0.0044326886025773 NA NA NA hsa-miR-92b-3p MAP3K2 0.418630595140165 6.50466149211154e-05 -0.162416139107452 0.102046585126356 miRNAWalker2_validate -0.156039394150691 0.00264579279779341 NA NA NA hsa-let-7i-5p MAP3K3 0.911372377723717 7.11483853341932e-31 -0.284369189864099 4.44443860177924e-07 miRNATAP -0.147986248438255 4.54603060887549e-05 NA NA NA hsa-miR-106b-5p MAP3K3 1.07509411417907 2.11739194181878e-36 -0.284369189864099 4.44443860177924e-07 MirTarget;miRNATAP -0.175275994282888 7.40973978572037e-08 NA NA NA hsa-miR-15a-5p MAP3K3 1.42663930007845 1.36006952074963e-57 -0.284369189864099 4.44443860177924e-07 MirTarget;miRNATAP -0.125259511543643 1.96693566818396e-05 NA NA NA hsa-miR-16-5p MAP3K3 0.934012514027655 4.85417898318515e-24 -0.284369189864099 4.44443860177924e-07 MirTarget;miRNATAP -0.118569859679141 0.000180208480412844 NA NA NA hsa-miR-17-5p MAP3K3 0.494260110870015 3.8348005261e-09 -0.284369189864099 4.44443860177924e-07 MirTarget;TargetScan;miRNATAP -0.102426229044085 0.00554590924512488 NA NA NA hsa-miR-181b-5p MAP3K3 1.49054296272357 3.69051660739368e-41 -0.284369189864099 4.44443860177924e-07 MirTarget;miRNATAP -0.120851510292426 9.50915273362935e-07 NA NA NA hsa-miR-193a-3p MAP3K3 0.849206638484406 3.68101781083335e-14 -0.284369189864099 4.44443860177924e-07 PITA;miRNATAP -0.11685396997679 1.31234595263309e-05 NA NA NA hsa-miR-22-3p MAP3K3 0.198460552200729 0.00761005672059428 -0.284369189864099 4.44443860177924e-07 MirTarget;miRNATAP -0.112860753859143 0.00830063014208163 NA NA NA hsa-miR-331-3p MAP3K3 0.431607034018882 6.83022920590941e-05 -0.284369189864099 4.44443860177924e-07 mirMAP -0.111140006936483 0.000106655622549072 NA NA NA hsa-miR-93-5p MAP3K3 1.37365940377595 2.37567548683245e-46 -0.284369189864099 4.44443860177924e-07 MirTarget;miRNATAP -0.136921836767676 1.05872790678578e-06 NA NA NA hsa-miR-107 MAP3K4 0.140046250553248 0.0943611632552367 -0.204162158260407 0.000105018735984799 miRanda -0.102013908103144 0.00367066748345889 NA NA NA hsa-miR-148a-3p MAP3K4 0.343233211643815 0.00402279073598165 -0.204162158260407 0.000105018735984799 miRNAWalker2_validate -0.134767517483741 1.7704731142728e-08 NA NA NA hsa-miR-15a-5p MAP3K4 1.42663930007845 1.36006952074963e-57 -0.204162158260407 0.000105018735984799 miRNATAP -0.134851760210604 6.11592510531981e-07 NA NA NA hsa-miR-15b-5p MAP3K4 0.773001494057531 1.71784656078957e-16 -0.204162158260407 0.000105018735984799 miRNATAP -0.152447261710111 1.98092501818382e-07 NA NA NA hsa-miR-16-5p MAP3K4 0.934012514027655 4.85417898318515e-24 -0.204162158260407 0.000105018735984799 miRNATAP -0.1597348682447 3.45014778177217e-08 NA NA NA hsa-miR-193a-3p MAP3K4 0.849206638484406 3.68101781083335e-14 -0.204162158260407 0.000105018735984799 miRanda -0.128587163869448 1.88149813254224e-07 NA NA NA hsa-miR-590-3p MAP3K4 1.13702599385212 3.53435739887793e-22 -0.204162158260407 0.000105018735984799 miRanda -0.103868333821052 6.58119694326677e-06 NA NA NA hsa-miR-93-5p MAP3K4 1.37365940377595 2.37567548683245e-46 -0.204162158260407 0.000105018735984799 miRNAWalker2_validate -0.111820590344008 1.82036499270624e-05 NA NA NA hsa-miR-362-5p MAP3K6 -2.72767654824605 1.34821749679113e-49 0.834481930418701 1.29350763121197e-14 miRNATAP -0.214063967645557 1.33734980154317e-14 NA NA NA hsa-let-7b-3p MAP3K8 0.239865279324672 0.00721479815526816 0.70586898760109 7.4113027577868e-10 MirTarget -0.228078393357235 0.00177948382202008 NA NA NA hsa-let-7g-3p MAP3K8 -0.265047454512772 0.0213585204640049 0.70586898760109 7.4113027577868e-10 MirTarget -0.243346531213977 1.38721703465977e-05 NA NA NA hsa-miR-139-5p MAP3K8 -0.704802495091118 2.36904108453776e-06 0.70586898760109 7.4113027577868e-10 miRanda -0.230294620518512 4.61840589864659e-08 NA NA NA hsa-miR-23b-3p MAP3K8 -0.533749586990474 2.46924776953771e-10 0.70586898760109 7.4113027577868e-10 MirTarget -0.513786736692421 2.25440463155563e-12 NA NA NA hsa-miR-429 MAP3K8 -2.16569233119434 2.66862243626443e-37 0.70586898760109 7.4113027577868e-10 PITA;miRanda -0.107116077851446 0.00160437374182256 NA NA NA hsa-miR-501-5p MAP3K8 -1.1103073934745 1.81589804886553e-16 0.70586898760109 7.4113027577868e-10 PITA;miRNATAP -0.179748574385748 8.20665921695507e-05 NA NA NA hsa-miR-30c-2-3p MAP4K1 -1.28402709024345 6.77577627955178e-25 2.92477149324563 1.34843106874198e-39 MirTarget -1.00770517858648 7.07138735147638e-26 NA NA NA hsa-let-7a-3p MAP4K3 0.0677487960013088 0.460458477653989 -0.971052528474908 2.53011271984349e-40 mirMAP -0.200418566951564 5.9639054069377e-05 NA NA NA hsa-let-7b-3p MAP4K3 0.239865279324672 0.00721479815526816 -0.971052528474908 2.53011271984349e-40 mirMAP -0.178222514931009 0.000507244139187473 NA NA NA hsa-let-7b-5p MAP4K3 0.770868211539597 6.63408323707647e-21 -0.971052528474908 2.53011271984349e-40 MirTarget;miRNATAP -0.391784466210261 9.72081821913323e-15 NA NA NA hsa-let-7f-1-3p MAP4K3 0.477913872379336 4.46669616865068e-05 -0.971052528474908 2.53011271984349e-40 mirMAP -0.188082807963955 5.99084455551617e-06 NA NA NA hsa-let-7i-5p MAP4K3 0.911372377723717 7.11483853341932e-31 -0.971052528474908 2.53011271984349e-40 MirTarget;miRNATAP -0.371119725439651 4.82088239496791e-13 NA NA NA hsa-miR-142-3p MAP4K3 1.88928758773299 2.72985643829893e-22 -0.971052528474908 2.53011271984349e-40 miRanda;miRNATAP -0.170035504777401 4.91604300328222e-16 NA NA NA hsa-miR-155-5p MAP4K3 3.26274490570809 5.06841441826518e-51 -0.971052528474908 2.53011271984349e-40 MirTarget -0.191285639972811 4.26783782089423e-32 NA NA NA hsa-miR-186-5p MAP4K3 0.507217561043443 9.04455748270995e-10 -0.971052528474908 2.53011271984349e-40 miRNATAP -0.342620280538364 9.18847788668572e-11 NA NA NA hsa-miR-196a-5p MAP4K3 0.440858887700369 2.0077143292463e-05 -0.971052528474908 2.53011271984349e-40 MirTarget;miRNATAP -0.196334041734475 6.29380095048926e-06 NA NA NA hsa-miR-19a-3p MAP4K3 0.722913586880779 2.76301458932381e-10 -0.971052528474908 2.53011271984349e-40 MirTarget -0.185723648006845 1.36234148027563e-06 NA NA NA hsa-miR-19b-3p MAP4K3 0.195940928879427 0.0300512922542325 -0.971052528474908 2.53011271984349e-40 MirTarget -0.167671971085468 0.00096423729971868 NA NA NA hsa-miR-21-3p MAP4K3 1.78837590049697 1.41655409877312e-33 -0.971052528474908 2.53011271984349e-40 MirTarget -0.257671741459184 2.92741358630793e-23 NA NA NA hsa-miR-338-3p MAP4K3 0.906250377628867 2.76970900371139e-15 -0.971052528474908 2.53011271984349e-40 MirTarget;PITA;miRanda -0.186137677312771 8.01097917455242e-07 NA NA NA hsa-miR-338-5p MAP4K3 0.628429807914222 1.27575140717947e-06 -0.971052528474908 2.53011271984349e-40 PITA;mirMAP -0.135541207858281 0.000117204639810885 NA NA NA hsa-miR-340-5p MAP4K3 1.14479851941741 2.91936881701444e-15 -0.971052528474908 2.53011271984349e-40 MirTarget -0.165431458381899 2.29209455922946e-08 NA NA NA hsa-miR-342-3p MAP4K3 1.4124432570595 1.07208971556131e-28 -0.971052528474908 2.53011271984349e-40 miRanda -0.279909582729645 2.64159241614996e-19 NA NA NA hsa-miR-374a-5p MAP4K3 0.543061152108237 2.19403097299769e-14 -0.971052528474908 2.53011271984349e-40 MirTarget;mirMAP -0.372862548823694 1.06502805590964e-09 NA NA NA hsa-miR-590-3p MAP4K3 1.13702599385212 3.53435739887793e-22 -0.971052528474908 2.53011271984349e-40 PITA;miRanda;mirMAP -0.242139137206975 8.43751657482759e-12 NA NA NA hsa-let-7e-5p MAP4K4 -0.727009689927955 1.30690859412163e-11 1.24904174638485 3.69490965321647e-48 MirTarget -0.137133541236333 0.00584987465465593 NA NA NA hsa-let-7g-5p MAP4K4 -0.739744008507763 1.07979566264383e-14 1.24904174638485 3.69490965321647e-48 MirTarget -0.25049455671514 4.88762367439522e-06 NA NA NA hsa-miR-10a-5p MAP4K4 -1.17164272592931 4.86621098042279e-24 1.24904174638485 3.69490965321647e-48 MirTarget -0.335995258822098 2.20104402694884e-15 NA NA NA hsa-miR-10b-5p MAP4K4 -0.89971464210447 1.18190532299934e-20 1.24904174638485 3.69490965321647e-48 MirTarget -0.256813919271581 1.34515147188653e-06 NA NA NA hsa-miR-141-3p MAP4K4 -5.87110686537457 1.20877726722907e-85 1.24904174638485 3.69490965321647e-48 TargetScan -0.163758393474838 5.04414153021105e-39 24013097 To understand how miR-141 mediates the phenotype of pancreatic cancer cells a bioinformatics tool was used to identify MAP4K4 as a potential target of miR-141; The Dual-Luciferase reporter gene assay showed that miR-141 binds directly to the 3'-untranslated region 3'UTR of MAP4K4 to inhibit MAP4K4 expression; Western blot and quantitative real-time PCR qRT-PCR analyses revealed that MAP4K4 expression was inversely correlated with miR-141 expression both in pancreatic cancer samples and cell lines; In a nude mouse xenograft model both overexpression of miR-141 and knockdown of MAP4K4 significantly repressed pancreatic cancer cell growth; Therefore we conclude that miR-141 targets MAP4K4 acts as a tumor suppressor in pancreatic cancer cells and may serve as a novel therapeutic agent for miRNA-based pancreatic cancer therapy pancreatic cancer hsa-miR-182-5p MAP4K4 -0.608710746044567 0.0025264935278104 1.24904174638485 3.69490965321647e-48 MirTarget -0.11637593847097 1.48878220763866e-05 NA NA NA hsa-miR-200b-3p MAP4K4 -1.70383252137161 2.38979336321755e-30 1.24904174638485 3.69490965321647e-48 TargetScan -0.38552291419866 4.6642573051171e-38 NA NA NA hsa-miR-204-5p MAP4K4 -1.67490789640238 9.14741888352476e-10 1.24904174638485 3.69490965321647e-48 MirTarget -0.110076079385775 9.07867822153059e-09 NA NA NA hsa-miR-23b-3p MAP4K4 -0.533749586990474 2.46924776953771e-10 1.24904174638485 3.69490965321647e-48 MirTarget;miRNATAP -0.296857389684021 2.71251120397588e-06 NA NA NA hsa-miR-29a-3p MAP4K4 -0.431613225927952 4.10166815070288e-08 1.24904174638485 3.69490965321647e-48 miRNATAP -0.359112075101684 1.39428263719726e-07 NA NA NA hsa-miR-29b-3p MAP4K4 -0.228125979913806 0.0271621721891603 1.24904174638485 3.69490965321647e-48 miRNATAP -0.213622874334498 5.72632626275131e-05 NA NA NA hsa-miR-29c-3p MAP4K4 -0.238671318446745 0.0141475322347596 1.24904174638485 3.69490965321647e-48 miRNATAP -0.258834717916052 4.04093179464934e-06 NA NA NA hsa-miR-3065-3p MAP4K4 -1.64500070417457 9.57561660036697e-16 1.24904174638485 3.69490965321647e-48 miRNATAP -0.177262101079474 7.95562292414901e-13 NA NA NA hsa-miR-33a-5p MAP4K4 -1.59840463890997 1.13487952314403e-18 1.24904174638485 3.69490965321647e-48 MirTarget -0.166691321207768 3.4613126460314e-09 NA NA NA hsa-miR-429 MAP4K4 -2.16569233119434 2.66862243626443e-37 1.24904174638485 3.69490965321647e-48 PITA;miRanda;miRNATAP -0.316275017292497 3.24037719012273e-34 NA NA NA hsa-miR-96-5p MAP4K4 -1.00223771166604 3.91564621567028e-06 1.24904174638485 3.69490965321647e-48 TargetScan -0.139459163672259 3.42474311620274e-08 NA NA NA hsa-let-7a-3p MAPK1 0.0677487960013088 0.460458477653989 0.0752350253994916 0.244227817396104 mirMAP -0.120937214673988 0.00189910022756462 NA NA NA hsa-miR-221-3p MAPK1 0.337895669520713 0.0136448974691037 0.0752350253994916 0.244227817396104 mirMAP -0.18533006750384 1.05774724669662e-13 NA NA NA hsa-miR-222-3p MAPK1 0.214811008033524 0.0965295551752457 0.0752350253994916 0.244227817396104 mirMAP -0.111381984547009 4.49766515770734e-05 NA NA NA hsa-miR-29a-3p MAPK1 -0.431613225927952 4.10166815070288e-08 0.0752350253994916 0.244227817396104 mirMAP -0.199785129647306 6.26938786529944e-06 NA NA NA hsa-miR-29c-3p MAPK1 -0.238671318446745 0.0141475322347596 0.0752350253994916 0.244227817396104 mirMAP -0.118476374132015 0.00117661250325827 NA NA NA hsa-miR-30b-5p MAPK1 -1.18330589477119 6.8341618466966e-27 0.0752350253994916 0.244227817396104 mirMAP -0.126400578163208 1.7728740776704e-05 NA NA NA hsa-miR-130b-3p MAPK10 1.12788913578446 2.939369462276e-16 -1.21487132791135 4.28083849239698e-29 miRNATAP -0.426865766422543 6.2125228747084e-24 NA NA NA hsa-miR-146b-5p MAPK10 1.40714170253819 2.9559871816487e-12 -1.21487132791135 4.28083849239698e-29 miRanda -0.238154498396656 2.40916717729571e-15 NA NA NA hsa-miR-193a-3p MAPK10 0.849206638484406 3.68101781083335e-14 -1.21487132791135 4.28083849239698e-29 miRanda;miRNATAP -0.477791684724428 3.60529507654292e-19 NA NA NA hsa-miR-19a-3p MAPK10 0.722913586880779 2.76301458932381e-10 -1.21487132791135 4.28083849239698e-29 miRNATAP -0.350806870796812 1.13510508025726e-10 NA NA NA hsa-miR-19b-3p MAPK10 0.195940928879427 0.0300512922542325 -1.21487132791135 4.28083849239698e-29 miRNATAP -0.309366846213377 1.96850100098747e-05 NA NA NA hsa-miR-221-3p MAPK10 0.337895669520713 0.0136448974691037 -1.21487132791135 4.28083849239698e-29 miRNATAP -0.257156072087272 4.41278059795946e-08 NA NA NA hsa-miR-222-3p MAPK10 0.214811008033524 0.0965295551752457 -1.21487132791135 4.28083849239698e-29 miRNATAP -0.299797013226272 1.63347653838624e-09 NA NA NA hsa-miR-29b-3p MAPK10 -0.228125979913806 0.0271621721891603 -1.21487132791135 4.28083849239698e-29 miRNATAP -0.196078455627514 0.00205832566182426 24767251 The percentage of positive myeloid cell leukemia sequence 1 ATG9A and MAPK10 protein expression and low miR-29b mRNA expression were significantly higher in cases with clinical stage III and IV ovarian cancer than in cases with clinical stage II ovarian cancer; Univariate Kaplan-Meier analysis showed a negative correlation between MAPK10 or ATG9A protein expression and overall as well as progression-free survival whereas a positive correlation was observed between miR-29b mRNA expression and overall as well as progression-free survival; Multivariate Cox regression analysis showed that elevated MAPK10 or ATG9A protein and lowered miR-29b mRNA expression in ovarian carcinoma was an independent poor prognostic predictor; Our study suggested that miR-29b mRNA MAPK10 protein expression and ATG9A protein expression are closely related to chemosensitivity of ovarian carcinoma staging;progression;poor survival ovarian cancer hsa-miR-301a-3p MAPK10 0.259400847075798 0.0216890736701418 -1.21487132791135 4.28083849239698e-29 miRNATAP -0.206875912734593 0.000352634513303849 NA NA NA hsa-miR-330-3p MAPK10 0.912906550436308 3.35037014057665e-13 -1.21487132791135 4.28083849239698e-29 PITA;miRNATAP -0.23056537801525 6.24801819994022e-06 NA NA NA hsa-miR-454-3p MAPK10 0.68285296887698 1.17407812677787e-08 -1.21487132791135 4.28083849239698e-29 miRNATAP -0.340810695000248 7.01951489670639e-11 NA NA NA hsa-miR-590-3p MAPK10 1.13702599385212 3.53435739887793e-22 -1.21487132791135 4.28083849239698e-29 miRanda;mirMAP -0.400723704396593 1.46142734104843e-15 NA NA NA hsa-miR-590-5p MAPK10 0.709763558412506 1.11883921359361e-11 -1.21487132791135 4.28083849239698e-29 PITA;miRanda;miRNATAP -0.384956181913074 9.15169986554425e-11 NA NA NA hsa-miR-24-3p MAPK14 0.173813044685099 0.00565259443420961 -0.1906269679268 0.000282305210520484 miRNAWalker2_validate;miRTarBase;MirTarget -0.144363998896302 0.00209395672973458 NA NA NA hsa-miR-200b-3p MAPK7 -1.70383252137161 2.38979336321755e-30 0.545125095097417 7.92822788207773e-14 MirTarget -0.15268467667014 9.70896212580208e-10 NA NA NA hsa-miR-429 MAPK7 -2.16569233119434 2.66862243626443e-37 0.545125095097417 7.92822788207773e-14 MirTarget;miRanda -0.1182132722965 3.90175865535515e-08 NA NA NA hsa-let-7a-3p MAPK8 0.0677487960013088 0.460458477653989 -0.750160075359857 1.06943990640368e-11 mirMAP -0.224745732614521 0.00113114965599641 NA NA NA hsa-let-7f-1-3p MAPK8 0.477913872379336 4.46669616865068e-05 -0.750160075359857 1.06943990640368e-11 mirMAP -0.198193629510422 0.000578100841933834 NA NA NA hsa-miR-130b-3p MAPK8 1.12788913578446 2.939369462276e-16 -0.750160075359857 1.06943990640368e-11 mirMAP -0.300046383602671 1.12283314104074e-12 NA NA NA hsa-miR-140-3p MAPK8 0.989350547007025 6.14964028267239e-25 -0.750160075359857 1.06943990640368e-11 miRNAWalker2_validate -0.21607071391855 0.000381512783937793 NA NA NA hsa-miR-16-2-3p MAPK8 1.3046118743965 4.17207934608428e-19 -0.750160075359857 1.06943990640368e-11 mirMAP -0.230603960728852 7.35216005494181e-09 NA NA NA hsa-miR-193b-3p MAPK8 -0.273325765316079 0.104328826585392 -0.750160075359857 1.06943990640368e-11 miRNAWalker2_validate -0.115617600028936 0.00194240080077243 NA NA NA hsa-miR-22-5p MAPK8 -0.197038086012602 0.106234828461117 -0.750160075359857 1.06943990640368e-11 mirMAP -0.269908296695586 1.14728279558826e-07 NA NA NA hsa-miR-374a-3p MAPK8 1.13863935833993 2.79089304015401e-44 -0.750160075359857 1.06943990640368e-11 mirMAP -0.289709574010348 1.55055266358389e-05 NA NA NA hsa-miR-590-3p MAPK8 1.13702599385212 3.53435739887793e-22 -0.750160075359857 1.06943990640368e-11 miRNATAP -0.262993606467664 1.07257214255814e-07 NA NA NA hsa-miR-185-3p MAPK8IP1 0.993379985307475 2.62011454953707e-13 -1.08468640758566 2.74073530482085e-19 MirTarget -0.238867167367021 2.02303185760754e-06 NA NA NA hsa-miR-330-5p MAPK8IP1 1.44960468659754 2.12131210588035e-45 -1.08468640758566 2.74073530482085e-19 miRanda -0.407143436784904 2.43861684937416e-12 NA NA NA hsa-let-7b-5p MAPK8IP2 0.770868211539597 6.63408323707647e-21 -0.744915198293831 0.000375412272928943 mirMAP -0.387121667243577 0.00391964626976041 NA NA NA hsa-miR-15a-5p MAPK8IP2 1.42663930007845 1.36006952074963e-57 -0.744915198293831 0.000375412272928943 mirMAP -0.373019228266851 0.000643173050992463 NA NA NA hsa-miR-10a-5p MAPK8IP3 -1.17164272592931 4.86621098042279e-24 1.72945880249415 1.69257321876691e-24 mirMAP -0.266437092971109 0.000980778846665864 NA NA NA hsa-miR-10b-5p MAPK8IP3 -0.89971464210447 1.18190532299934e-20 1.72945880249415 1.69257321876691e-24 mirMAP -0.498597960390398 2.9320964080353e-07 NA NA NA hsa-miR-125a-3p MAPK8IP3 -0.372794471295036 0.000941729459601642 1.72945880249415 1.69257321876691e-24 miRanda -0.280406834295084 0.00168038199136028 NA NA NA hsa-miR-149-5p MAPK8IP3 -1.95790336710741 8.46371715052367e-27 1.72945880249415 1.69257321876691e-24 mirMAP -0.335500843136706 1.05652952755146e-11 NA NA NA hsa-miR-194-3p MAPK8IP3 -0.0573594560647068 0.802137112420482 1.72945880249415 1.69257321876691e-24 mirMAP -0.127164015899036 0.00436249236355155 NA NA NA hsa-miR-218-5p MAPK8IP3 -0.81077534785501 3.0631582201951e-08 1.72945880249415 1.69257321876691e-24 miRNATAP -0.293330768203959 1.15043596988258e-05 NA NA NA hsa-miR-27b-3p MAPK8IP3 -0.699527231242518 1.07356023759234e-15 1.72945880249415 1.69257321876691e-24 miRNATAP -0.417997388248378 0.000159228132960572 NA NA NA hsa-miR-30b-3p MAPK8IP3 -1.64703050862226 1.89878531036464e-31 1.72945880249415 1.69257321876691e-24 mirMAP -0.55475647502585 2.43114375941666e-19 NA NA NA hsa-miR-324-3p MAPK8IP3 -0.197662887871899 0.0298845059559819 1.72945880249415 1.69257321876691e-24 MirTarget -0.644367243943014 3.91028260651655e-09 NA NA NA hsa-miR-326 MAPK8IP3 0.0283498662828876 0.83943976716391 1.72945880249415 1.69257321876691e-24 mirMAP -0.35458670192896 6.70917068969851e-07 NA NA NA hsa-miR-429 MAPK8IP3 -2.16569233119434 2.66862243626443e-37 1.72945880249415 1.69257321876691e-24 miRNATAP -0.19545586740701 0.000199971519583226 NA NA NA hsa-miR-432-5p MAPK8IP3 -0.381985611608938 0.0372906502320596 1.72945880249415 1.69257321876691e-24 mirMAP -0.181556873756027 0.00121443915537451 NA NA NA hsa-miR-539-5p MAPK8IP3 -1.44841597031461 8.25650852878567e-11 1.72945880249415 1.69257321876691e-24 mirMAP -0.320841155366026 1.65407843009545e-13 NA NA NA hsa-miR-664a-5p MAPK8IP3 -0.618481839889218 7.01961389909184e-09 1.72945880249415 1.69257321876691e-24 mirMAP -0.570500439591759 2.75891805605616e-10 NA NA NA hsa-miR-766-3p MAPK8IP3 -0.230617949950715 0.0566289375252083 1.72945880249415 1.69257321876691e-24 mirMAP -0.275460358627804 0.000944453195034454 NA NA NA hsa-miR-940 MAPK8IP3 -0.160421460715008 0.279016637176929 1.72945880249415 1.69257321876691e-24 miRNATAP -0.218591786092322 0.00213408217796347 NA NA NA hsa-miR-24-3p MAPK9 0.173813044685099 0.00565259443420961 0.14417034408476 0.00521298953478229 miRNATAP -0.189071350720719 3.44779387721655e-05 NA NA NA hsa-miR-27b-3p MAPK9 -0.699527231242518 1.07356023759234e-15 0.14417034408476 0.00521298953478229 miRNAWalker2_validate -0.147750560718002 1.80817169396102e-06 NA NA NA hsa-miR-10a-5p MAPT -1.17164272592931 4.86621098042279e-24 1.34064328469193 4.24878924335179e-07 mirMAP -0.483251882070288 4.82306820710105e-05 NA NA NA hsa-miR-132-3p MAPT 0.291409674711894 0.000912684337101876 1.34064328469193 4.24878924335179e-07 MirTarget -0.815520574313925 1.18664369730182e-06 NA NA NA hsa-miR-212-3p MAPT 0.140490094813501 0.298248972687012 1.34064328469193 4.24878924335179e-07 MirTarget -0.370675561721841 0.000856033251537895 NA NA NA hsa-miR-214-5p MAPT -1.44418790803397 1.50873538772684e-16 1.34064328469193 4.24878924335179e-07 MirTarget -0.248019329808962 0.00221283060889407 NA NA NA hsa-miR-29a-5p MAPT -0.519003718107105 1.03351148282116e-06 1.34064328469193 4.24878924335179e-07 MirTarget;miRNATAP -0.531781638240117 0.00011451276119204 NA NA NA hsa-miR-335-5p MAPT -2.09515619961552 1.03765771499548e-25 1.34064328469193 4.24878924335179e-07 mirMAP -0.430892082790895 1.99148427661765e-10 NA NA NA hsa-miR-495-3p MAPT -0.742293735164333 7.11373308013543e-05 1.34064328469193 4.24878924335179e-07 mirMAP -0.330736815011742 4.27227492122652e-05 NA NA NA hsa-miR-766-3p MAPT -0.230617949950715 0.0566289375252083 1.34064328469193 4.24878924335179e-07 MirTarget -0.650363982758668 8.48211695544875e-08 NA NA NA hsa-miR-874-3p MAPT -1.50243370621573 8.39418307315909e-25 1.34064328469193 4.24878924335179e-07 MirTarget -0.244365347659355 0.0097483745290343 NA NA NA hsa-miR-96-5p MAPT -1.00223771166604 3.91564621567028e-06 1.34064328469193 4.24878924335179e-07 mirMAP -0.574096074213295 4.28822725069891e-18 NA NA NA hsa-let-7g-5p MEF2C -0.739744008507763 1.07979566264383e-14 1.18850699554719 2.40959602606182e-26 miRNATAP -0.272958164350605 4.65433739770141e-05 NA NA NA hsa-miR-10a-3p MEF2C -1.40380922426511 3.42207767326254e-23 1.18850699554719 2.40959602606182e-26 miRNATAP -0.307379556664331 2.11651647351234e-12 NA NA NA hsa-miR-135b-5p MEF2C -1.12731059106515 6.06922867778145e-08 1.18850699554719 2.40959602606182e-26 MirTarget -0.111900975352609 0.000402096203229912 NA NA NA hsa-miR-182-5p MEF2C -0.608710746044567 0.0025264935278104 1.18850699554719 2.40959602606182e-26 MirTarget;miRNATAP -0.171559504305642 1.33108594982931e-07 NA NA NA hsa-miR-183-5p MEF2C -1.21596931064487 1.31473205758898e-08 1.18850699554719 2.40959602606182e-26 MirTarget;miRNATAP -0.209154679494919 1.60648867035922e-12 NA NA NA hsa-miR-188-5p MEF2C -1.74586655806628 1.50431624674552e-28 1.18850699554719 2.40959602606182e-26 MirTarget;PITA -0.348160502587731 4.04167915865852e-20 NA NA NA hsa-miR-203a-3p MEF2C -2.25533513338731 1.77332845294014e-21 1.18850699554719 2.40959602606182e-26 MirTarget -0.106889922680087 4.64475916222576e-05 NA NA NA hsa-miR-22-5p MEF2C -0.197038086012602 0.106234828461117 1.18850699554719 2.40959602606182e-26 MirTarget -0.259893839727512 1.81358000769052e-06 NA NA NA hsa-miR-26a-1-3p MEF2C -1.56107117111696 6.75439319582901e-15 1.18850699554719 2.40959602606182e-26 mirMAP -0.142058438174891 1.25153998197996e-05 NA NA NA hsa-miR-27b-3p MEF2C -0.699527231242518 1.07356023759234e-15 1.18850699554719 2.40959602606182e-26 miRNATAP -0.224358726325294 0.00237863238448176 NA NA NA hsa-miR-30a-3p MEF2C -0.955360819934585 1.97009535429185e-20 1.18850699554719 2.40959602606182e-26 MirTarget;miRNATAP -0.297000024813056 9.4364202553592e-07 NA NA NA hsa-miR-30d-3p MEF2C -0.249777194282131 0.00235356711813496 1.18850699554719 2.40959602606182e-26 MirTarget;miRNATAP -0.289079352432669 0.000406383907330825 NA NA NA hsa-miR-30e-3p MEF2C -0.205602546270795 0.00132666419729688 1.18850699554719 2.40959602606182e-26 MirTarget;mirMAP -0.277429532374048 0.00900418609244386 NA NA NA hsa-miR-335-3p MEF2C -1.36498175550207 6.84287752180534e-13 1.18850699554719 2.40959602606182e-26 MirTarget;mirMAP -0.136046969410522 5.63817605330981e-05 NA NA NA hsa-miR-362-3p MEF2C -0.753214251798232 3.0025661608035e-07 1.18850699554719 2.40959602606182e-26 MirTarget;miRNATAP -0.270258269273666 2.32783054923247e-09 NA NA NA hsa-miR-429 MEF2C -2.16569233119434 2.66862243626443e-37 1.18850699554719 2.40959602606182e-26 miRanda;miRNATAP -0.264043518828834 4.56610441104887e-15 NA NA NA hsa-miR-501-5p MEF2C -1.1103073934745 1.81589804886553e-16 1.18850699554719 2.40959602606182e-26 MirTarget;PITA;miRNATAP -0.301901113651573 5.91470381512689e-11 NA NA NA hsa-miR-96-5p MEF2C -1.00223771166604 3.91564621567028e-06 1.18850699554719 2.40959602606182e-26 miRNATAP -0.211032432945519 3.79508371648235e-12 NA NA NA hsa-miR-125a-3p MKNK1 -0.372794471295036 0.000941729459601642 0.625970759793597 6.39042580852115e-27 miRanda -0.104430255401374 0.000689920273827596 NA NA NA hsa-miR-29a-5p MKNK1 -0.519003718107105 1.03351148282116e-06 0.625970759793597 6.39042580852115e-27 mirMAP -0.106545238784441 0.000975382859870778 NA NA NA hsa-miR-423-5p MKNK2 0.250929012519631 0.00288495915028486 0.161234868146632 0.0177386470681207 miRNAWalker2_validate;MirTarget -0.189853304802446 1.87128166636973e-05 NA NA NA hsa-let-7b-5p MRAS 0.770868211539597 6.63408323707647e-21 -0.554669193598587 1.52363396365892e-08 mirMAP -0.23615819907007 0.000193405187111281 NA NA NA hsa-miR-15a-5p MRAS 1.42663930007845 1.36006952074963e-57 -0.554669193598587 1.52363396365892e-08 miRNATAP -0.231362633411201 6.99096086029183e-06 NA NA NA hsa-miR-16-5p MRAS 0.934012514027655 4.85417898318515e-24 -0.554669193598587 1.52363396365892e-08 miRNATAP -0.152352262008386 0.00643137849661952 NA NA NA hsa-miR-330-5p MRAS 1.44960468659754 2.12131210588035e-45 -0.554669193598587 1.52363396365892e-08 miRanda -0.160562688895322 0.000591299493148386 NA NA NA hsa-miR-338-3p MRAS 0.906250377628867 2.76970900371139e-15 -0.554669193598587 1.52363396365892e-08 miRanda -0.176764185931236 0.000119202735511636 NA NA NA hsa-let-7g-5p MYC -0.739744008507763 1.07979566264383e-14 1.69954133129988 7.75526107259408e-27 miRNAWalker2_validate;miRTarBase -0.398905767136213 2.71236287032834e-05 NA NA NA hsa-miR-135a-5p MYC -2.13422485001223 6.29449029671498e-14 1.69954133129988 7.75526107259408e-27 miRNAWalker2_validate -0.108827259333515 0.000903589484065675 23176581 Moreover based on the results of this analysis we investigated whether miR-135a targeted the c-MYC gene in RCC; Gain-of-function and luciferase reporter assays showed that c-MYC was directly regulated by miR-135a in RCC cells kidney renal cell cancer hsa-miR-335-5p MYC -2.09515619961552 1.03765771499548e-25 1.69954133129988 7.75526107259408e-27 miRNAWalker2_validate -0.216426299788151 7.62566723121896e-07 NA NA NA hsa-miR-429 MYC -2.16569233119434 2.66862243626443e-37 1.69954133129988 7.75526107259408e-27 miRNAWalker2_validate -0.389721783902253 2.72292816859272e-16 21684154;24633485 miR 429 modulates the expression of c myc in human gastric carcinoma cells; SGC-7901 gastric cancer cells were transfected with miR-429 mimics and endogenous c-myc expression was detected by western blots; We performed functional assays using the 3'UTR of the c-myc gene as a miR-429 target in a luciferase reporter assay system; miR-429 significantly downregulated endogenous c-myc expression in SGC-7901 cells; Action of miR/429 on c-myc 3'UTR was confirmed; c-myc is an important miR-429 target gene;It is known that miR-429 is down-regulated and functions as a tumor suppressor by targeting c-myc and PLGG1 in gastric and breast cancer ; gastric cancer;sarcoma hsa-miR-744-5p MYC -0.348985243196771 0.000187889982228835 1.69954133129988 7.75526107259408e-27 miRNAWalker2_validate -0.377458526504721 0.000190443255959769 24991193 Decrease expression of microRNA 744 promotes cell proliferation by targeting c Myc in human hepatocellular carcinoma; Quantitative reverse-transcription polymerase chain reaction qRT-PCR was conducted to detect the expression of miR-744 and Immunohistochemistry was performed to detect expression of c-Myc in HCC specimens and adjacent normal tissues; Luciferase reporter assays was performed to confirm whether miR-744 regulated the expression of c-Myc; Luciferase assay and Western blot analysis revealed that c-Myc is a direct target of miR-744; Down-regulation of miR-744 and up-regulation of c-Myc were detected in HCC specimens compared with adjacent normal tissues; Moreover restoration of miR-744 rescues c-Myc induced HCC proliferation; Our data suggest that miR-744 exerts its tumor suppressor function by targeting c-Myc leading to the inhibition of HCC cell growth liver cancer hsa-let-7a-3p NF1 0.0677487960013088 0.460458477653989 -0.278582655858325 3.19619777018965e-05 mirMAP -0.16583406341185 4.5517347241611e-05 NA NA NA hsa-let-7f-1-3p NF1 0.477913872379336 4.46669616865068e-05 -0.278582655858325 3.19619777018965e-05 mirMAP -0.113626683455709 0.000862952146948667 NA NA NA hsa-miR-103a-3p NF1 0.779373475434461 7.37867196796994e-20 -0.278582655858325 3.19619777018965e-05 MirTarget -0.132358328711865 0.0013497057752787 NA NA NA hsa-miR-128-3p NF1 0.475045893035043 2.6255647468e-06 -0.278582655858325 3.19619777018965e-05 MirTarget -0.11265279417326 0.00198752649104985 NA NA NA hsa-miR-15a-5p NF1 1.42663930007845 1.36006952074963e-57 -0.278582655858325 3.19619777018965e-05 MirTarget -0.158221764357537 5.06318712030949e-06 NA NA NA hsa-miR-15b-5p NF1 0.773001494057531 1.71784656078957e-16 -0.278582655858325 3.19619777018965e-05 MirTarget -0.136525136861035 0.000313808033418001 NA NA NA hsa-miR-193a-3p NF1 0.849206638484406 3.68101781083335e-14 -0.278582655858325 3.19619777018965e-05 miRanda -0.178191979159234 1.44209785114945e-08 NA NA NA hsa-miR-27a-3p NF1 0.558934437526245 1.44256383086177e-12 -0.278582655858325 3.19619777018965e-05 MirTarget -0.291452353781108 7.83292657919896e-11 NA NA NA hsa-miR-28-5p NF1 0.461962042257226 3.32424690573327e-11 -0.278582655858325 3.19619777018965e-05 miRanda -0.261029606371927 4.95406042023725e-07 NA NA NA hsa-miR-330-5p NF1 1.44960468659754 2.12131210588035e-45 -0.278582655858325 3.19619777018965e-05 miRanda -0.116269768237763 0.00021849086941097 NA NA NA hsa-miR-590-3p NF1 1.13702599385212 3.53435739887793e-22 -0.278582655858325 3.19619777018965e-05 MirTarget;PITA;miRanda;miRNATAP -0.120520490418901 4.5428332941545e-05 NA NA NA hsa-miR-590-5p NF1 0.709763558412506 1.11883921359361e-11 -0.278582655858325 3.19619777018965e-05 miRanda -0.146874585973214 1.90748914030311e-05 NA NA NA hsa-miR-200b-5p NFATC2 -1.46985752435972 3.43232443788022e-27 0.449362525468644 0.0189141879480816 mirMAP -0.195303131766132 0.00675711085179978 NA NA NA hsa-miR-30b-5p NFATC2 -1.18330589477119 6.8341618466966e-27 0.449362525468644 0.0189141879480816 MirTarget;mirMAP -0.463461325382204 1.11191040571271e-07 NA NA NA hsa-miR-30c-5p NFATC2 -1.08783070774238 2.02505402525786e-24 0.449362525468644 0.0189141879480816 MirTarget;mirMAP -0.271805009769506 0.00325762769077695 NA NA NA hsa-miR-29b-3p NFATC4 -0.228125979913806 0.0271621721891603 0.47344681025823 0.000946723727006422 miRNATAP -0.402505484576897 1.23032680444856e-07 NA NA NA hsa-miR-29c-3p NFATC4 -0.238671318446745 0.0141475322347596 0.47344681025823 0.000946723727006422 miRNATAP -0.265114702444064 0.00120757439920213 NA NA NA hsa-miR-3607-3p NFATC4 -0.529788328085356 0.00511771034738625 0.47344681025823 0.000946723727006422 miRNATAP -0.24036070829863 4.41456153455456e-09 NA NA NA hsa-miR-532-5p NFATC4 -1.09700348358668 8.34836230254408e-26 0.47344681025823 0.000946723727006422 mirMAP -0.404648362035331 4.91036144881753e-09 NA NA NA hsa-miR-625-5p NFATC4 0.153090549230629 0.330314026509869 0.47344681025823 0.000946723727006422 mirMAP -0.201502679108411 0.000224845731258786 NA NA NA hsa-miR-629-3p NFATC4 1.09330044556689 2.9533160808356e-14 0.47344681025823 0.000946723727006422 mirMAP -0.150504690909161 0.00533757723845502 NA NA NA hsa-miR-501-5p NFKB2 -1.1103073934745 1.81589804886553e-16 1.15445646421959 1.69452430081858e-27 PITA;miRNATAP -0.166482149434142 0.000211423931031999 NA NA NA hsa-let-7g-5p NGF -0.739744008507763 1.07979566264383e-14 1.68176218451818 4.25883926715749e-21 MirTarget -0.604104636667389 5.7443559092026e-09 NA NA NA hsa-miR-429 NGF -2.16569233119434 2.66862243626443e-37 1.68176218451818 4.25883926715749e-21 miRanda -0.274846404242145 4.10102515693054e-07 NA NA NA hsa-let-7b-5p NLK 0.770868211539597 6.63408323707647e-21 -0.415191050072129 3.56761964031379e-14 miRNATAP -0.213142443996496 1.59741249912824e-09 NA NA NA hsa-let-7i-5p NLK 0.911372377723717 7.11483853341932e-31 -0.415191050072129 3.56761964031379e-14 miRNATAP -0.15295813080395 2.30171838649547e-05 NA NA NA hsa-miR-101-3p NLK 0.683973909682285 2.88573524246948e-15 -0.415191050072129 3.56761964031379e-14 MirTarget;miRNATAP -0.133297067953379 0.000121545107269618 24189458 MiR 101 functions as a tumor suppressor by directly targeting nemo like kinase in liver cancer; Ectopic expression of miRNA mimics suggested that miR-101 could suppress NLK in HCC cells; Notably ectopic miR-101 expression repressed cancer cell growth and proliferation and imitated NLK knockdown effect on HCC cells; In conclusion we suggest that miR-101 functions as a tumor suppressor by regulating abnormal NLK activity in liver liver cancer hsa-miR-140-5p NLK 0.504309496243674 3.09884038729031e-11 -0.415191050072129 3.56761964031379e-14 MirTarget;PITA;miRanda;miRNATAP -0.11126456870982 0.00601003022746845 NA NA NA hsa-miR-181a-5p NLK 1.11111114875339 3.97880443756442e-29 -0.415191050072129 3.56761964031379e-14 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.129246509443587 6.73584541111371e-06 NA NA NA hsa-miR-181b-5p NLK 1.49054296272357 3.69051660739368e-41 -0.415191050072129 3.56761964031379e-14 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.123014704665365 5.43054049724413e-07 NA NA NA hsa-miR-19a-3p NLK 0.722913586880779 2.76301458932381e-10 -0.415191050072129 3.56761964031379e-14 miRNATAP -0.11681032889775 1.00048435447221e-05 NA NA NA hsa-miR-19b-3p NLK 0.195940928879427 0.0300512922542325 -0.415191050072129 3.56761964031379e-14 miRNATAP -0.112498547421501 0.00124622865639122 NA NA NA hsa-miR-23a-3p NLK 0.761438723382355 4.09310879199257e-27 -0.415191050072129 3.56761964031379e-14 miRNAWalker2_validate;MirTarget -0.26618905195001 3.62422734867895e-11 NA NA NA hsa-miR-24-3p NLK 0.173813044685099 0.00565259443420961 -0.415191050072129 3.56761964031379e-14 miRNATAP -0.186569360466789 0.00022297719711918 NA NA NA hsa-miR-25-3p NLK 1.12016166564779 3.79069348635778e-48 -0.415191050072129 3.56761964031379e-14 MirTarget;miRNATAP -0.248032048255658 3.93931440544525e-13 NA NA NA hsa-miR-27a-3p NLK 0.558934437526245 1.44256383086177e-12 -0.415191050072129 3.56761964031379e-14 miRNATAP -0.229917022523536 1.26715697659659e-09 NA NA NA hsa-miR-28-5p NLK 0.461962042257226 3.32424690573327e-11 -0.415191050072129 3.56761964031379e-14 miRanda -0.213854603663167 1.00934235622274e-06 NA NA NA hsa-miR-32-5p NLK 0.407826130035097 7.26884631998646e-06 -0.415191050072129 3.56761964031379e-14 MirTarget;miRNATAP -0.115912233572337 0.000694797834639195 NA NA NA hsa-miR-330-5p NLK 1.44960468659754 2.12131210588035e-45 -0.415191050072129 3.56761964031379e-14 MirTarget;PITA;miRanda;miRNATAP -0.119824580519251 5.32913342569724e-06 NA NA NA hsa-miR-342-3p NLK 1.4124432570595 1.07208971556131e-28 -0.415191050072129 3.56761964031379e-14 miRanda -0.106193658441937 1.96644391627061e-06 NA NA NA hsa-miR-576-5p NLK 1.06681109513983 5.69294424466526e-24 -0.415191050072129 3.56761964031379e-14 MirTarget;PITA -0.145124878973303 9.73821201873753e-08 NA NA NA hsa-miR-590-3p NLK 1.13702599385212 3.53435739887793e-22 -0.415191050072129 3.56761964031379e-14 PITA;miRanda;mirMAP;miRNATAP -0.118746280650687 1.60415916418526e-06 NA NA NA hsa-miR-590-5p NLK 0.709763558412506 1.11883921359361e-11 -0.415191050072129 3.56761964031379e-14 miRanda -0.130841023902023 5.79659168032456e-06 NA NA NA hsa-miR-92a-3p NLK 0.178194888895831 0.0088835082650834 -0.415191050072129 3.56761964031379e-14 MirTarget;miRNATAP -0.137090969174483 0.00328930488596389 NA NA NA hsa-miR-92b-3p NLK 0.418630595140165 6.50466149211154e-05 -0.415191050072129 3.56761964031379e-14 miRNAWalker2_validate;MirTarget;miRNATAP -0.102401695791903 0.00055081635376696 NA NA NA hsa-miR-93-5p NR4A1 1.37365940377595 2.37567548683245e-46 -1.28964885901639 4.74745690194872e-08 miRNAWalker2_validate -0.647466848675217 4.3635401018505e-08 NA NA NA hsa-miR-26a-5p NRAS -0.202091714279613 0.00166918288801054 0.34448791512356 4.92740995926564e-07 mirMAP;miRNATAP -0.190676842662057 0.00158798186993403 26458859 MiR 26a enhances the sensitivity of gastric cancer cells to cisplatin by targeting NRAS and E2F2; Our results suggest that miR-26a can improve the sensitivity of GC cells to cisplatin-based chemotherapies through targeting NRAS and E2F2 and provide the first evidence of the potential utility of miR-26a as a sensitizer in chemotherapy for GC gastric cancer hsa-miR-27b-3p NRAS -0.699527231242518 1.07356023759234e-15 0.34448791512356 4.92740995926564e-07 miRNATAP -0.133554182026992 0.00155260770161313 NA NA NA hsa-miR-29a-3p NRAS -0.431613225927952 4.10166815070288e-08 0.34448791512356 4.92740995926564e-07 miRNATAP -0.260252250919602 4.11630497908065e-08 NA NA NA hsa-miR-29c-3p NRAS -0.238671318446745 0.0141475322347596 0.34448791512356 4.92740995926564e-07 miRNATAP -0.171085903480696 1.27586236636451e-05 NA NA NA hsa-miR-502-3p NRAS -1.10416310320528 1.55354569985732e-22 0.34448791512356 4.92740995926564e-07 MirTarget -0.127167715752408 5.47705696881981e-05 NA NA NA hsa-miR-142-3p NTF3 1.88928758773299 2.72985643829893e-22 -0.668855124592218 0.000140030636687871 miRanda -0.192970372635885 3.40296027412e-05 NA NA NA hsa-miR-21-5p NTF3 2.51462371613332 3.30620591950316e-66 -0.668855124592218 0.000140030636687871 miRTarBase;miRNATAP -0.202004999552495 0.000189117552740546 NA NA NA hsa-miR-221-3p NTF3 0.337895669520713 0.0136448974691037 -0.668855124592218 0.000140030636687871 miRNATAP -0.191983307441267 0.00712732397760743 NA NA NA hsa-miR-222-3p NTF3 0.214811008033524 0.0965295551752457 -0.668855124592218 0.000140030636687871 miRNATAP -0.286460458871947 0.000146481856047174 NA NA NA hsa-miR-590-3p NTF3 1.13702599385212 3.53435739887793e-22 -0.668855124592218 0.000140030636687871 miRanda -0.280720029817671 0.000312503544564494 NA NA NA hsa-miR-590-5p NTF3 0.709763558412506 1.11883921359361e-11 -0.668855124592218 0.000140030636687871 PITA;miRanda;miRNATAP -0.379489466442206 2.6461671900719e-05 NA NA NA hsa-miR-16-1-3p NTRK1 1.51429140700091 3.17219833254498e-37 -2.16917617916044 3.29741000934657e-22 mirMAP -0.547850527770562 3.2373436730389e-08 NA NA NA hsa-miR-185-3p NTRK1 0.993379985307475 2.62011454953707e-13 -2.16917617916044 3.29741000934657e-22 MirTarget -0.306701824990764 0.00125082909655452 NA NA NA hsa-miR-1271-5p NTRK2 0.900599702972936 3.07963385418853e-10 -2.73321393169747 3.3903895709546e-27 mirMAP -0.279489318800296 0.00692601449421045 NA NA NA hsa-miR-130b-3p NTRK2 1.12788913578446 2.939369462276e-16 -2.73321393169747 3.3903895709546e-27 mirMAP -0.726248428792849 1.06613529740873e-12 NA NA NA hsa-miR-130b-5p NTRK2 0.92990617673277 3.75880436852717e-12 -2.73321393169747 3.3903895709546e-27 mirMAP -0.664853909431365 5.97557240278784e-10 NA NA NA hsa-miR-140-3p NTRK2 0.989350547007025 6.14964028267239e-25 -2.73321393169747 3.3903895709546e-27 PITA -0.519386335791164 0.000414092080713394 NA NA NA hsa-miR-140-5p NTRK2 0.504309496243674 3.09884038729031e-11 -2.73321393169747 3.3903895709546e-27 miRanda -0.602681306142158 0.00214343631834989 NA NA NA hsa-miR-142-3p NTRK2 1.88928758773299 2.72985643829893e-22 -2.73321393169747 3.3903895709546e-27 miRanda -0.535926145944065 2.20805593228617e-14 NA NA NA hsa-miR-142-5p NTRK2 1.88417391525707 1.2096808039882e-27 -2.73321393169747 3.3903895709546e-27 mirMAP -0.630558350878623 2.91820135052768e-16 NA NA NA hsa-miR-146b-5p NTRK2 1.40714170253819 2.9559871816487e-12 -2.73321393169747 3.3903895709546e-27 PITA;miRanda -0.530011528937097 3.93751534627944e-14 NA NA NA hsa-miR-148a-5p NTRK2 0.415500302855613 0.000691460831436767 -2.73321393169747 3.3903895709546e-27 mirMAP -0.405140262998007 0.00102752820872671 NA NA NA hsa-miR-150-5p NTRK2 1.00371863159681 1.09871676395528e-09 -2.73321393169747 3.3903895709546e-27 mirMAP -0.350808561928945 8.73868933597758e-05 NA NA NA hsa-miR-155-5p NTRK2 3.26274490570809 5.06841441826518e-51 -2.73321393169747 3.3903895709546e-27 mirMAP -0.523772868638065 9.71166995832331e-21 NA NA NA hsa-miR-15b-3p NTRK2 1.49422666971434 5.44139893275088e-29 -2.73321393169747 3.3903895709546e-27 mirMAP -0.883103230853508 3.54431200556926e-19 NA NA NA hsa-miR-17-3p NTRK2 0.723795600017259 5.90151677164931e-18 -2.73321393169747 3.3903895709546e-27 miRNATAP -0.896939124509083 1.53151658135195e-07 NA NA NA hsa-miR-181a-5p NTRK2 1.11111114875339 3.97880443756442e-29 -2.73321393169747 3.3903895709546e-27 mirMAP -0.733342857770367 1.20516883867811e-07 NA NA NA hsa-miR-181b-5p NTRK2 1.49054296272357 3.69051660739368e-41 -2.73321393169747 3.3903895709546e-27 mirMAP -0.862482081682885 1.35863838260511e-13 NA NA NA hsa-miR-185-5p NTRK2 1.05056378692621 1.31174187880682e-22 -2.73321393169747 3.3903895709546e-27 mirMAP -0.903531978686805 2.07831492195628e-12 NA NA NA hsa-miR-186-5p NTRK2 0.507217561043443 9.04455748270995e-10 -2.73321393169747 3.3903895709546e-27 mirMAP -0.751111378776912 2.81517737650002e-05 NA NA NA hsa-miR-21-5p NTRK2 2.51462371613332 3.30620591950316e-66 -2.73321393169747 3.3903895709546e-27 mirMAP -0.866304204214476 4.74626449144815e-29 NA NA NA hsa-miR-22-3p NTRK2 0.198460552200729 0.00761005672059428 -2.73321393169747 3.3903895709546e-27 miRNATAP -0.940887284040991 4.26647718326073e-06 27662840 NTRK2 is an oncogene and associated with microRNA 22 regulation in human gastric cancer cell lines; The upstream regulator of NTRK2 microRNA-22 miR-22 was evaluated by dual-luciferase assay; In miR-22-upregulated MKN-28 and SNU-719 cells NTRK2 was further overexpressed to evaluate functional interaction between miR-22 and NTRK2 in GC; MiR-22 was verified to be an inverse upstream regulator of NTRK2; NTRK2 is an oncogene and reversely associated with miR-22 in regulating in vitro cancer development in GC gastric cancer hsa-miR-224-3p NTRK2 0.918780460857403 2.47005991706282e-07 -2.73321393169747 3.3903895709546e-27 mirMAP -0.296880246942849 0.000601419642883547 NA NA NA hsa-miR-28-3p NTRK2 1.01277915413238 1.8655970171461e-43 -2.73321393169747 3.3903895709546e-27 mirMAP -1.55284291020704 3.13155796248004e-19 NA NA NA hsa-miR-301a-3p NTRK2 0.259400847075798 0.0216890736701418 -2.73321393169747 3.3903895709546e-27 mirMAP -0.404742958628509 0.00266401330037096 NA NA NA hsa-miR-32-5p NTRK2 0.407826130035097 7.26884631998646e-06 -2.73321393169747 3.3903895709546e-27 mirMAP -0.598949064606831 0.000301224488907791 NA NA NA hsa-miR-330-5p NTRK2 1.44960468659754 2.12131210588035e-45 -2.73321393169747 3.3903895709546e-27 miRanda -0.967842612453671 5.88353202789705e-15 NA NA NA hsa-miR-339-5p NTRK2 0.322848334531193 0.0117281778821612 -2.73321393169747 3.3903895709546e-27 miRanda -0.535957387929389 5.05171729322507e-06 NA NA NA hsa-miR-340-5p NTRK2 1.14479851941741 2.91936881701444e-15 -2.73321393169747 3.3903895709546e-27 mirMAP -0.399071788262657 6.273974375913e-05 NA NA NA hsa-miR-342-3p NTRK2 1.4124432570595 1.07208971556131e-28 -2.73321393169747 3.3903895709546e-27 miRanda -0.756935028269671 9.6439214022446e-13 NA NA NA hsa-miR-374a-5p NTRK2 0.543061152108237 2.19403097299769e-14 -2.73321393169747 3.3903895709546e-27 mirMAP -0.782462980478737 0.000158244892407905 NA NA NA hsa-miR-452-3p NTRK2 1.72039996672257 1.35748079442153e-22 -2.73321393169747 3.3903895709546e-27 mirMAP -0.530028502444608 3.6645564067277e-11 NA NA NA hsa-miR-452-5p NTRK2 2.05325688842141 2.82238393643084e-40 -2.73321393169747 3.3903895709546e-27 mirMAP -0.627797662843897 5.64553003041051e-14 NA NA NA hsa-miR-454-3p NTRK2 0.68285296887698 1.17407812677787e-08 -2.73321393169747 3.3903895709546e-27 mirMAP -0.687524402930162 1.88953043418862e-08 NA NA NA hsa-miR-576-5p NTRK2 1.06681109513983 5.69294424466526e-24 -2.73321393169747 3.3903895709546e-27 PITA;mirMAP -0.776948309330999 3.45345465514776e-09 NA NA NA hsa-miR-590-3p NTRK2 1.13702599385212 3.53435739887793e-22 -2.73321393169747 3.3903895709546e-27 PITA;miRanda;mirMAP -1.00386450655333 3.56539151155473e-18 NA NA NA hsa-miR-590-5p NTRK2 0.709763558412506 1.11883921359361e-11 -2.73321393169747 3.3903895709546e-27 miRanda;mirMAP -0.969172844259923 1.50709586782717e-12 NA NA NA hsa-miR-140-3p PAK2 0.989350547007025 6.14964028267239e-25 -0.0396753863732426 0.470587814692617 MirTarget;PITA;miRNATAP -0.103698735378074 0.000365655454195812 NA NA NA hsa-miR-26a-5p PAK2 -0.202091714279613 0.00166918288801054 -0.0396753863732426 0.470587814692617 MirTarget;miRNATAP -0.16141245794453 0.000654700712994406 NA NA NA hsa-miR-361-5p PAK2 0.0514169367202078 0.382929376393199 -0.0396753863732426 0.470587814692617 mirMAP -0.178324393753364 0.000649974256073914 NA NA NA hsa-miR-335-3p PDGFA -1.36498175550207 6.84287752180534e-13 0.784073561233544 6.85051005668436e-15 mirMAP -0.123406397724081 2.37431234661371e-05 NA NA NA hsa-let-7g-5p PDGFB -0.739744008507763 1.07979566264383e-14 0.514864266712336 1.3417847330971e-06 miRNATAP -0.206195775236675 0.000576759591890832 NA NA NA hsa-miR-29a-3p PDGFB -0.431613225927952 4.10166815070288e-08 0.514864266712336 1.3417847330971e-06 MirTarget;miRNATAP -0.476936960397935 7.15396531394664e-11 NA NA NA hsa-miR-29b-3p PDGFB -0.228125979913806 0.0271621721891603 0.514864266712336 1.3417847330971e-06 MirTarget;miRNATAP -0.405612933369531 4.60127322330892e-13 NA NA NA hsa-miR-335-5p PDGFB -2.09515619961552 1.03765771499548e-25 0.514864266712336 1.3417847330971e-06 mirMAP -0.118392042230392 1.77239536755918e-05 NA NA NA hsa-miR-362-3p PDGFB -0.753214251798232 3.0025661608035e-07 0.514864266712336 1.3417847330971e-06 miRanda -0.149895887453564 0.000254386338042802 NA NA NA hsa-let-7b-5p PDGFRA 0.770868211539597 6.63408323707647e-21 -3.78993218513957 5.84256232656759e-33 miRNAWalker2_validate -0.744189949569241 0.000853482541380744 NA NA NA hsa-miR-106b-5p PDGFRA 1.07509411417907 2.11739194181878e-36 -3.78993218513957 5.84256232656759e-33 MirTarget;miRNATAP -1.52699938391706 7.64844256452476e-15 NA NA NA hsa-miR-130b-3p PDGFRA 1.12788913578446 2.939369462276e-16 -3.78993218513957 5.84256232656759e-33 MirTarget;miRNATAP -0.367163537880206 0.00634739389951908 NA NA NA hsa-miR-142-5p PDGFRA 1.88417391525707 1.2096808039882e-27 -3.78993218513957 5.84256232656759e-33 PITA;mirMAP;miRNATAP -0.473816152387234 3.28987725776332e-06 NA NA NA hsa-miR-16-1-3p PDGFRA 1.51429140700091 3.17219833254498e-37 -3.78993218513957 5.84256232656759e-33 MirTarget -0.936133152915647 8.28916380630762e-11 NA NA NA hsa-miR-17-5p PDGFRA 0.494260110870015 3.8348005261e-09 -3.78993218513957 5.84256232656759e-33 MirTarget;TargetScan;miRNATAP -1.12023059618189 6.47834222552057e-07 NA NA NA hsa-miR-181a-5p PDGFRA 1.11111114875339 3.97880443756442e-29 -3.78993218513957 5.84256232656759e-33 MirTarget;miRNATAP -1.13167968181832 1.00578978735371e-10 NA NA NA hsa-miR-181b-5p PDGFRA 1.49054296272357 3.69051660739368e-41 -3.78993218513957 5.84256232656759e-33 MirTarget;miRNATAP -1.0831393363512 3.58334758184159e-13 NA NA NA hsa-miR-186-5p PDGFRA 0.507217561043443 9.04455748270995e-10 -3.78993218513957 5.84256232656759e-33 MirTarget -0.76722366281197 0.00085346453663738 NA NA NA hsa-miR-193a-3p PDGFRA 0.849206638484406 3.68101781083335e-14 -3.78993218513957 5.84256232656759e-33 miRanda -0.670433703095133 5.33609287809933e-05 NA NA NA hsa-miR-196a-5p PDGFRA 0.440858887700369 2.0077143292463e-05 -3.78993218513957 5.84256232656759e-33 MirTarget;miRNATAP -0.807966664131365 1.24871502376204e-05 NA NA NA hsa-miR-20a-5p PDGFRA 0.702602695798242 4.06372887613329e-13 -3.78993218513957 5.84256232656759e-33 MirTarget;miRNATAP -1.0995133850917 7.76850607822403e-09 NA NA NA hsa-miR-224-5p PDGFRA 2.84654230414912 3.0480927226395e-47 -3.78993218513957 5.84256232656759e-33 MirTarget -0.560824939024689 9.29216493461181e-12 NA NA NA hsa-miR-27a-3p PDGFRA 0.558934437526245 1.44256383086177e-12 -3.78993218513957 5.84256232656759e-33 MirTarget;miRNATAP -0.88742400202454 0.000202616724972923 NA NA NA hsa-miR-28-5p PDGFRA 0.461962042257226 3.32424690573327e-11 -3.78993218513957 5.84256232656759e-33 miRanda -0.92447717530526 0.000728496310352206 NA NA NA hsa-miR-330-5p PDGFRA 1.44960468659754 2.12131210588035e-45 -3.78993218513957 5.84256232656759e-33 miRanda -0.905908236362134 2.16923297258051e-08 NA NA NA hsa-miR-338-3p PDGFRA 0.906250377628867 2.76970900371139e-15 -3.78993218513957 5.84256232656759e-33 miRanda -0.637819265775912 7.72917116687921e-05 NA NA NA hsa-miR-338-5p PDGFRA 0.628429807914222 1.27575140717947e-06 -3.78993218513957 5.84256232656759e-33 mirMAP;miRNATAP -0.450795738987696 0.00269083695175716 NA NA NA hsa-miR-342-3p PDGFRA 1.4124432570595 1.07208971556131e-28 -3.78993218513957 5.84256232656759e-33 MirTarget;miRanda;miRNATAP -0.694461078438614 4.90067077355219e-07 NA NA NA hsa-miR-34a-5p PDGFRA 1.07544567720768 1.81510842038009e-20 -3.78993218513957 5.84256232656759e-33 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.873046587006104 1.72995840633287e-08 22750848 Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network glioblastoma hsa-miR-374a-5p PDGFRA 0.543061152108237 2.19403097299769e-14 -3.78993218513957 5.84256232656759e-33 mirMAP -0.874227666145286 0.000973487956615665 NA NA NA hsa-miR-454-3p PDGFRA 0.68285296887698 1.17407812677787e-08 -3.78993218513957 5.84256232656759e-33 MirTarget;miRNATAP -0.564425512169116 0.00036544900032461 NA NA NA hsa-miR-455-5p PDGFRA 0.773674551205946 2.12957541541474e-09 -3.78993218513957 5.84256232656759e-33 MirTarget;PITA;miRanda -0.947080211002297 3.30515111107968e-11 NA NA NA hsa-miR-542-3p PDGFRA 0.431147917094433 0.000254981247606435 -3.78993218513957 5.84256232656759e-33 miRanda -0.442130370438674 0.00699356752210394 NA NA NA hsa-miR-576-5p PDGFRA 1.06681109513983 5.69294424466526e-24 -3.78993218513957 5.84256232656759e-33 mirMAP -1.09144002614137 6.09402828933535e-11 NA NA NA hsa-miR-590-3p PDGFRA 1.13702599385212 3.53435739887793e-22 -3.78993218513957 5.84256232656759e-33 miRanda;mirMAP -0.970020105353422 1.43465903827534e-10 NA NA NA hsa-miR-590-5p PDGFRA 0.709763558412506 1.11883921359361e-11 -3.78993218513957 5.84256232656759e-33 miRanda -0.805041348062301 6.78234301048255e-06 NA NA NA hsa-miR-616-5p PDGFRA 0.913426384742148 3.78418389333709e-09 -3.78993218513957 5.84256232656759e-33 mirMAP -0.558608482543338 5.68208963722558e-06 NA NA NA hsa-miR-7-1-3p PDGFRA 0.544601828025304 5.33830451326047e-07 -3.78993218513957 5.84256232656759e-33 mirMAP -0.741792492104915 2.27057862094563e-05 NA NA NA hsa-miR-93-5p PDGFRA 1.37365940377595 2.37567548683245e-46 -3.78993218513957 5.84256232656759e-33 MirTarget;miRNATAP -1.44923917304051 3.40005219888479e-18 NA NA NA hsa-miR-29a-3p PDGFRB -0.431613225927952 4.10166815070288e-08 0.733059789264273 9.08256836273142e-08 miRNATAP -0.452409180680295 2.53894645761997e-06 NA NA NA hsa-miR-29b-3p PDGFRB -0.228125979913806 0.0271621721891603 0.733059789264273 9.08256836273142e-08 miRNATAP -0.473479216745421 9.29300376624436e-11 NA NA NA hsa-miR-29c-3p PDGFRB -0.238671318446745 0.0141475322347596 0.733059789264273 9.08256836273142e-08 miRNATAP -0.358531848837518 5.48317704341144e-06 NA NA NA hsa-miR-664a-3p PDGFRB -0.019312777079624 0.825861598748857 0.733059789264273 9.08256836273142e-08 MirTarget -0.347941365487638 8.25629516369049e-05 NA NA NA hsa-miR-106b-5p PLA2G12A 1.07509411417907 2.11739194181878e-36 -0.398969072863746 5.55717944273617e-08 mirMAP -0.318990060549306 2.29217198651414e-14 NA NA NA hsa-miR-140-5p PLA2G12A 0.504309496243674 3.09884038729031e-11 -0.398969072863746 5.55717944273617e-08 miRanda -0.188599257543893 0.000382484546134811 NA NA NA hsa-miR-142-5p PLA2G12A 1.88417391525707 1.2096808039882e-27 -0.398969072863746 5.55717944273617e-08 mirMAP -0.138073144669251 9.04790839331805e-11 NA NA NA hsa-miR-150-5p PLA2G12A 1.00371863159681 1.09871676395528e-09 -0.398969072863746 5.55717944273617e-08 mirMAP -0.14806285256437 5.07167045463163e-10 NA NA NA hsa-miR-16-2-3p PLA2G12A 1.3046118743965 4.17207934608428e-19 -0.398969072863746 5.55717944273617e-08 mirMAP -0.111423414392617 2.54085038058137e-05 NA NA NA hsa-miR-17-3p PLA2G12A 0.723795600017259 5.90151677164931e-18 -0.398969072863746 5.55717944273617e-08 mirMAP -0.246147322379887 1.06111832675154e-07 NA NA NA hsa-miR-17-5p PLA2G12A 0.494260110870015 3.8348005261e-09 -0.398969072863746 5.55717944273617e-08 mirMAP -0.172159927457143 0.000360024830260926 NA NA NA hsa-miR-181a-5p PLA2G12A 1.11111114875339 3.97880443756442e-29 -0.398969072863746 5.55717944273617e-08 mirMAP -0.208596329981168 2.61179244938667e-08 NA NA NA hsa-miR-181b-5p PLA2G12A 1.49054296272357 3.69051660739368e-41 -0.398969072863746 5.55717944273617e-08 mirMAP -0.191772279611356 2.18947515885896e-09 NA NA NA hsa-miR-181c-5p PLA2G12A 0.762784646696248 4.48373118147729e-10 -0.398969072863746 5.55717944273617e-08 mirMAP -0.120873469964364 0.0002220646158873 NA NA NA hsa-miR-186-5p PLA2G12A 0.507217561043443 9.04455748270995e-10 -0.398969072863746 5.55717944273617e-08 mirMAP -0.167023490324012 0.00062699328283718 NA NA NA hsa-miR-20a-5p PLA2G12A 0.702602695798242 4.06372887613329e-13 -0.398969072863746 5.55717944273617e-08 mirMAP -0.131580419112628 0.00139337128447633 NA NA NA hsa-miR-330-3p PLA2G12A 0.912906550436308 3.35037014057665e-13 -0.398969072863746 5.55717944273617e-08 miRNATAP -0.145697955190855 5.6577432220273e-06 NA NA NA hsa-miR-374a-3p PLA2G12A 1.13863935833993 2.79089304015401e-44 -0.398969072863746 5.55717944273617e-08 mirMAP -0.14651878955133 0.000919658365223926 NA NA NA hsa-miR-590-3p PLA2G12A 1.13702599385212 3.53435739887793e-22 -0.398969072863746 5.55717944273617e-08 PITA;miRanda;miRNATAP -0.144365381787861 9.87289711374494e-06 NA NA NA hsa-miR-625-3p PLA2G12A 1.09679549288964 4.60800634006165e-20 -0.398969072863746 5.55717944273617e-08 mirMAP -0.225068546092664 8.61375480674311e-13 NA NA NA hsa-miR-92b-3p PLA2G12A 0.418630595140165 6.50466149211154e-05 -0.398969072863746 5.55717944273617e-08 miRNAWalker2_validate -0.195561990632176 4.06793360999897e-07 NA NA NA hsa-miR-93-5p PLA2G12A 1.37365940377595 2.37567548683245e-46 -0.398969072863746 5.55717944273617e-08 mirMAP -0.163143512838149 9.92914696804009e-06 NA NA NA hsa-miR-30c-2-3p PLA2G2D -1.28402709024345 6.77577627955178e-25 3.25786426267112 1.63883282978629e-21 mirMAP -1.4911913745295 5.06954471302161e-27 NA NA NA hsa-miR-1301-3p PLA2G4A 0.393537638993954 0.000390498879474539 -1.85529407773687 1.9717892081168e-32 MirTarget -0.276077994739491 0.00127728289438848 NA NA NA hsa-miR-142-3p PLA2G4A 1.88928758773299 2.72985643829893e-22 -1.85529407773687 1.9717892081168e-32 miRanda -0.176304107715065 0.000110262875817659 NA NA NA hsa-miR-144-3p PLA2G4A 1.4617706700291 9.18139413836375e-11 -1.85529407773687 1.9717892081168e-32 MirTarget -0.132461250631428 0.00125728302023368 NA NA NA hsa-miR-146b-5p PLA2G4A 1.40714170253819 2.9559871816487e-12 -1.85529407773687 1.9717892081168e-32 miRNAWalker2_validate -0.158304464185306 0.000517342945920931 NA NA NA hsa-miR-181a-5p PLA2G4A 1.11111114875339 3.97880443756442e-29 -1.85529407773687 1.9717892081168e-32 MirTarget -0.547914249646334 2.17897779368898e-10 NA NA NA hsa-miR-181b-5p PLA2G4A 1.49054296272357 3.69051660739368e-41 -1.85529407773687 1.9717892081168e-32 MirTarget -0.580974807139508 1.44687429049341e-15 NA NA NA hsa-miR-181d-5p PLA2G4A 1.00720380524132 6.04219503683814e-14 -1.85529407773687 1.9717892081168e-32 MirTarget -0.188540383634248 0.00595973754453785 NA NA NA hsa-miR-361-5p PLA2G4A 0.0514169367202078 0.382929376393199 -1.85529407773687 1.9717892081168e-32 miRanda -0.504250919786896 0.00245854577917651 NA NA NA hsa-miR-374a-5p PLA2G4A 0.543061152108237 2.19403097299769e-14 -1.85529407773687 1.9717892081168e-32 mirMAP -0.477322231169729 0.000249501916746624 NA NA NA hsa-miR-374b-5p PLA2G4A 0.0804104684417872 0.365593963035077 -1.85529407773687 1.9717892081168e-32 mirMAP -0.293947726971175 0.006867825439803 NA NA NA hsa-miR-590-3p PLA2G4A 1.13702599385212 3.53435739887793e-22 -1.85529407773687 1.9717892081168e-32 miRanda -0.489193495036296 4.85569925069997e-11 NA NA NA hsa-miR-125a-5p PLA2G5 -0.561874059994802 7.3931856356891e-13 2.9004312005942 1.2325420826324e-27 miRanda -1.07156821996216 4.64642714926677e-08 NA NA NA hsa-miR-429 PLA2G5 -2.16569233119434 2.66862243626443e-37 2.9004312005942 1.2325420826324e-27 miRanda -0.668499359545984 7.01186997138673e-17 NA NA NA hsa-miR-324-5p PLA2G6 -0.487750893426456 3.74472736457965e-05 0.682316411790433 7.33596322664269e-06 miRanda -0.282227835071844 6.91880555505667e-05 NA NA NA hsa-let-7a-3p PPM1A 0.0677487960013088 0.460458477653989 -0.724374009523378 1.40844886573211e-22 MirTarget;miRNATAP -0.12609628914907 0.00877023075588994 NA NA NA hsa-let-7f-1-3p PPM1A 0.477913872379336 4.46669616865068e-05 -0.724374009523378 1.40844886573211e-22 MirTarget -0.173895564277273 1.24580782112235e-05 NA NA NA hsa-miR-106b-5p PPM1A 1.07509411417907 2.11739194181878e-36 -0.724374009523378 1.40844886573211e-22 mirMAP -0.508904065043376 9.58075978222543e-35 NA NA NA hsa-miR-140-3p PPM1A 0.989350547007025 6.14964028267239e-25 -0.724374009523378 1.40844886573211e-22 miRNATAP -0.232330659374413 2.48041413838018e-08 NA NA NA hsa-miR-142-5p PPM1A 1.88417391525707 1.2096808039882e-27 -0.724374009523378 1.40844886573211e-22 mirMAP -0.203522009342941 1.15538434287259e-20 NA NA NA hsa-miR-146b-3p PPM1A 1.20941495066078 2.12939149602665e-10 -0.724374009523378 1.40844886573211e-22 miRNATAP -0.175302788753197 1.83657657440242e-16 NA NA NA hsa-miR-146b-5p PPM1A 1.40714170253819 2.9559871816487e-12 -0.724374009523378 1.40844886573211e-22 miRanda;miRNATAP -0.171172547715675 7.49575236788357e-18 NA NA NA hsa-miR-15a-5p PPM1A 1.42663930007845 1.36006952074963e-57 -0.724374009523378 1.40844886573211e-22 MirTarget;miRNATAP -0.348758812787318 3.35716120010474e-19 NA NA NA hsa-miR-15b-5p PPM1A 0.773001494057531 1.71784656078957e-16 -0.724374009523378 1.40844886573211e-22 MirTarget;miRNATAP -0.353161688756451 1.22906690903355e-16 NA NA NA hsa-miR-16-1-3p PPM1A 1.51429140700091 3.17219833254498e-37 -0.724374009523378 1.40844886573211e-22 mirMAP -0.231598401965502 6.55105601353076e-13 NA NA NA hsa-miR-16-5p PPM1A 0.934012514027655 4.85417898318515e-24 -0.724374009523378 1.40844886573211e-22 MirTarget;miRNATAP -0.288897300617134 1.8136393000922e-11 NA NA NA hsa-miR-17-5p PPM1A 0.494260110870015 3.8348005261e-09 -0.724374009523378 1.40844886573211e-22 TargetScan;mirMAP -0.259684316822225 2.90024438116045e-07 NA NA NA hsa-miR-186-5p PPM1A 0.507217561043443 9.04455748270995e-10 -0.724374009523378 1.40844886573211e-22 mirMAP;miRNATAP -0.286994543555984 1.81834076442425e-08 NA NA NA hsa-miR-195-5p PPM1A 0.346502644882604 0.0092562828415903 -0.724374009523378 1.40844886573211e-22 MirTarget;miRNATAP -0.153731604013256 2.10740111247198e-06 NA NA NA hsa-miR-21-3p PPM1A 1.78837590049697 1.41655409877312e-33 -0.724374009523378 1.40844886573211e-22 MirTarget -0.25036282110828 4.70682427550702e-24 NA NA NA hsa-miR-224-3p PPM1A 0.918780460857403 2.47005991706282e-07 -0.724374009523378 1.40844886573211e-22 mirMAP -0.110030686681389 8.50377910272956e-06 NA NA NA hsa-miR-23a-3p PPM1A 0.761438723382355 4.09310879199257e-27 -0.724374009523378 1.40844886573211e-22 mirMAP -0.463340619594927 3.52353814415827e-17 NA NA NA hsa-miR-28-3p PPM1A 1.01277915413238 1.8655970171461e-43 -0.724374009523378 1.40844886573211e-22 miRNATAP -0.424517467584145 2.38953388588425e-17 NA NA NA hsa-miR-320a PPM1A 0.412740558379182 2.02929519701706e-05 -0.724374009523378 1.40844886573211e-22 miRanda -0.278795133163395 1.92461159171974e-10 NA NA NA hsa-miR-320b PPM1A 0.300497419754843 0.0245219177384172 -0.724374009523378 1.40844886573211e-22 miRanda -0.181400713792338 1.60617741832262e-08 NA NA NA hsa-miR-340-5p PPM1A 1.14479851941741 2.91936881701444e-15 -0.724374009523378 1.40844886573211e-22 mirMAP -0.165523915738345 4.69965245960309e-09 NA NA NA hsa-miR-34a-5p PPM1A 1.07544567720768 1.81510842038009e-20 -0.724374009523378 1.40844886573211e-22 miRNATAP -0.286519000782632 2.51050945892129e-17 NA NA NA hsa-miR-3613-5p PPM1A 1.6648190889407 3.78720979041391e-41 -0.724374009523378 1.40844886573211e-22 miRNATAP -0.292047591504981 1.24644501824276e-23 NA NA NA hsa-miR-374a-5p PPM1A 0.543061152108237 2.19403097299769e-14 -0.724374009523378 1.40844886573211e-22 mirMAP -0.267712011512275 6.22074221218278e-06 NA NA NA hsa-miR-484 PPM1A 0.571987778099603 9.67278224458421e-10 -0.724374009523378 1.40844886573211e-22 miRNAWalker2_validate -0.255966918631027 1.26686063636602e-08 NA NA NA hsa-miR-497-5p PPM1A 0.227757383708836 0.0600073987853074 -0.724374009523378 1.40844886573211e-22 MirTarget;miRNATAP -0.1572785989804 1.1530791694905e-05 NA NA NA hsa-miR-542-3p PPM1A 0.431147917094433 0.000254981247606435 -0.724374009523378 1.40844886573211e-22 MirTarget -0.115616816432826 0.00169600041864999 NA NA NA hsa-miR-584-5p PPM1A 2.09455345496517 1.01738783798409e-51 -0.724374009523378 1.40844886573211e-22 MirTarget -0.132028584526311 6.27322786938119e-07 NA NA NA hsa-miR-590-3p PPM1A 1.13702599385212 3.53435739887793e-22 -0.724374009523378 1.40844886573211e-22 miRanda;mirMAP -0.228794904592211 1.59082761793213e-11 NA NA NA hsa-miR-590-5p PPM1A 0.709763558412506 1.11883921359361e-11 -0.724374009523378 1.40844886573211e-22 miRanda -0.204304890521267 3.4881413372186e-07 NA NA NA hsa-miR-7-1-3p PPM1A 0.544601828025304 5.33830451326047e-07 -0.724374009523378 1.40844886573211e-22 mirMAP -0.176142676778124 7.63337997642866e-06 NA NA NA hsa-miR-93-5p PPM1A 1.37365940377595 2.37567548683245e-46 -0.724374009523378 1.40844886573211e-22 mirMAP -0.328522731928976 1.87788018279568e-18 NA NA NA hsa-miR-106b-5p PPM1B 1.07509411417907 2.11739194181878e-36 -0.631688423216255 3.05747952200374e-33 miRNAWalker2_validate -0.310651168206583 7.05212786831084e-23 NA NA NA hsa-miR-126-5p PPM1B 0.785607261431085 5.77058629454465e-13 -0.631688423216255 3.05747952200374e-33 mirMAP -0.137908162701389 8.98455987626051e-07 NA NA NA hsa-miR-130b-3p PPM1B 1.12788913578446 2.939369462276e-16 -0.631688423216255 3.05747952200374e-33 mirMAP -0.114843231146186 1.48726748339106e-07 NA NA NA hsa-miR-181a-5p PPM1B 1.11111114875339 3.97880443756442e-29 -0.631688423216255 3.05747952200374e-33 mirMAP;miRNATAP -0.210433560365701 1.91605402429923e-13 NA NA NA hsa-miR-181b-5p PPM1B 1.49054296272357 3.69051660739368e-41 -0.631688423216255 3.05747952200374e-33 mirMAP;miRNATAP -0.207557583502996 9.91626500577035e-18 NA NA NA hsa-miR-181c-5p PPM1B 0.762784646696248 4.48373118147729e-10 -0.631688423216255 3.05747952200374e-33 miRNATAP -0.106097412847508 2.86013249892566e-05 NA NA NA hsa-miR-186-5p PPM1B 0.507217561043443 9.04455748270995e-10 -0.631688423216255 3.05747952200374e-33 MirTarget;mirMAP;miRNATAP -0.126152262787542 0.000890690390631633 26494000 miR 186 downregulates protein phosphatase PPM1B in bladder cancer and mediates G1 S phase transition; HT-1376 and RT4 cells were transduced to stably overexpress PPM1B and its predicted regulator miR-186; The results revealed that PPM1B was frequently downregulated in bladder cancer cells at both protein and messenger RNA mRNA levels whereas miR-186 was upregulated; Further analyses showed that miR-186 promoted G1-S transition by targeting PPM1B at its 3'-untranslated region 3'UTR; Conversely ectopic expression of PPM1B significantly suppressed proliferation and tumorigenicity in bladder cancer cells in vitro and in vivo thereby neutralizing the oncogenic effect of miR-186; This study has identified PPM1B and miR-186 as potential diagnostic markers in bladder cancer; Promotion of PPM1B and suppression of miR-186 may offer effective therapeutic strategies in the treatment of bladder cancer bladder cancer hsa-miR-320a PPM1B 0.412740558379182 2.02929519701706e-05 -0.631688423216255 3.05747952200374e-33 MirTarget;PITA;miRanda;miRNATAP -0.121652244096334 0.00020361080724021 NA NA NA hsa-miR-338-3p PPM1B 0.906250377628867 2.76970900371139e-15 -0.631688423216255 3.05747952200374e-33 PITA;miRanda -0.14717765247345 2.21750561739204e-08 NA NA NA hsa-miR-338-5p PPM1B 0.628429807914222 1.27575140717947e-06 -0.631688423216255 3.05747952200374e-33 PITA;mirMAP;miRNATAP -0.10709956006836 1.33638469433176e-05 NA NA NA hsa-miR-340-5p PPM1B 1.14479851941741 2.91936881701444e-15 -0.631688423216255 3.05747952200374e-33 mirMAP -0.101956898298547 1.0396266420614e-06 NA NA NA hsa-miR-342-3p PPM1B 1.4124432570595 1.07208971556131e-28 -0.631688423216255 3.05747952200374e-33 miRanda -0.123801407002041 4.95522816727433e-08 NA NA NA hsa-miR-361-3p PPM1B 1.08992546227594 1.13197240706704e-36 -0.631688423216255 3.05747952200374e-33 miRNATAP -0.179274835994475 4.66019089920475e-08 NA NA NA hsa-miR-374a-5p PPM1B 0.543061152108237 2.19403097299769e-14 -0.631688423216255 3.05747952200374e-33 MirTarget;mirMAP -0.128874450516135 0.00326674853482677 NA NA NA hsa-miR-542-3p PPM1B 0.431147917094433 0.000254981247606435 -0.631688423216255 3.05747952200374e-33 miRanda -0.120327898759739 7.02588653822345e-06 NA NA NA hsa-miR-590-3p PPM1B 1.13702599385212 3.53435739887793e-22 -0.631688423216255 3.05747952200374e-33 PITA;miRanda;mirMAP;miRNATAP -0.168084379526153 1.41041373282849e-11 NA NA NA hsa-miR-590-5p PPM1B 0.709763558412506 1.11883921359361e-11 -0.631688423216255 3.05747952200374e-33 miRanda -0.150149174417784 3.22557467207922e-07 NA NA NA hsa-miR-30a-5p PPP3CA -0.778411951775343 2.73322451127932e-16 0.0721387123808759 0.234245285293813 miRNAWalker2_validate;miRNATAP -0.118629097747329 0.000383615066757291 NA NA NA hsa-miR-107 PPP3CB 0.140046250553248 0.0943611632552367 -0.487246812937051 5.19737132609125e-20 miRanda -0.100574744257312 0.00721500275471322 NA NA NA hsa-miR-15a-5p PPP3CB 1.42663930007845 1.36006952074963e-57 -0.487246812937051 5.19737132609125e-20 miRNATAP -0.192283738442317 1.15661216413766e-11 NA NA NA hsa-miR-15b-5p PPP3CB 0.773001494057531 1.71784656078957e-16 -0.487246812937051 5.19737132609125e-20 miRNATAP -0.136453760306784 1.39939898640127e-05 NA NA NA hsa-miR-16-5p PPP3CB 0.934012514027655 4.85417898318515e-24 -0.487246812937051 5.19737132609125e-20 miRNATAP -0.134414377057782 1.56084628439769e-05 NA NA NA hsa-miR-330-5p PPP3CB 1.44960468659754 2.12131210588035e-45 -0.487246812937051 5.19737132609125e-20 MirTarget;PITA;miRanda -0.152969334053742 2.9174642891742e-09 NA NA NA hsa-miR-452-5p PPP3CB 2.05325688842141 2.82238393643084e-40 -0.487246812937051 5.19737132609125e-20 MirTarget;miRNATAP -0.117886106917456 6.18756426826884e-12 NA NA NA hsa-miR-590-3p PPP3CB 1.13702599385212 3.53435739887793e-22 -0.487246812937051 5.19737132609125e-20 miRanda -0.12233415261172 5.67792394940471e-07 NA NA NA hsa-miR-500a-3p PPP3CC -1.41379327701944 2.73403824528455e-37 0.254109049885576 7.06908011746755e-08 MirTarget;miRNATAP -0.121534092684039 4.7654464774239e-09 NA NA NA hsa-miR-27b-3p PPP3R1 -0.699527231242518 1.07356023759234e-15 0.157646059727901 0.00380302425401831 miRNATAP -0.147266842249843 7.02192582599604e-06 NA NA NA hsa-miR-30a-5p PPP3R1 -0.778411951775343 2.73322451127932e-16 0.157646059727901 0.00380302425401831 miRNAWalker2_validate;MirTarget;miRNATAP -0.144832345464806 1.24508531197761e-06 NA NA NA hsa-miR-30b-5p PPP3R1 -1.18330589477119 6.8341618466966e-27 0.157646059727901 0.00380302425401831 MirTarget -0.144184046476476 4.67346408532333e-09 NA NA NA hsa-miR-30d-5p PPP3R1 -0.202727675788184 0.00659067084745794 0.157646059727901 0.00380302425401831 MirTarget;miRNATAP -0.210347143440493 1.4459363165293e-07 NA NA NA hsa-miR-330-5p PPP5C 1.44960468659754 2.12131210588035e-45 -0.208736359602647 1.31113110454698e-05 miRanda -0.126974840000988 8.91944658822681e-09 NA NA NA hsa-miR-16-2-3p PRKACB 1.3046118743965 4.17207934608428e-19 -0.68047992720199 6.2289588419962e-18 mirMAP -0.110421791682537 0.000180893091391508 NA NA NA hsa-miR-17-5p PRKACB 0.494260110870015 3.8348005261e-09 -0.68047992720199 6.2289588419962e-18 TargetScan -0.177111212378275 0.000974492661946987 NA NA NA hsa-miR-18a-5p PRKACB 0.936704393213466 1.05064580570579e-10 -0.68047992720199 6.2289588419962e-18 miRNATAP -0.129810473204045 2.02983188773094e-05 NA NA NA hsa-miR-193a-3p PRKACB 0.849206638484406 3.68101781083335e-14 -0.68047992720199 6.2289588419962e-18 miRanda -0.152325629995289 0.000102213273809685 NA NA NA hsa-miR-19a-3p PRKACB 0.722913586880779 2.76301458932381e-10 -0.68047992720199 6.2289588419962e-18 MirTarget;miRNATAP -0.149521467816826 0.000117450056574833 NA NA NA hsa-miR-19b-3p PRKACB 0.195940928879427 0.0300512922542325 -0.68047992720199 6.2289588419962e-18 miRNAWalker2_validate;MirTarget;miRNATAP -0.151382160966433 0.0030186219386488 NA NA NA hsa-miR-34a-5p PRKACB 1.07544567720768 1.81510842038009e-20 -0.68047992720199 6.2289588419962e-18 miRNATAP -0.155553394908043 2.5599855449644e-05 NA NA NA hsa-miR-590-3p PRKACB 1.13702599385212 3.53435739887793e-22 -0.68047992720199 6.2289588419962e-18 MirTarget;PITA;miRanda;miRNATAP -0.170298039845818 2.59547529658115e-06 NA NA NA hsa-miR-590-5p PRKACB 0.709763558412506 1.11883921359361e-11 -0.68047992720199 6.2289588419962e-18 miRanda -0.122511813057726 0.00404292608644287 NA NA NA hsa-miR-93-5p PRKACB 1.37365940377595 2.37567548683245e-46 -0.68047992720199 6.2289588419962e-18 miRNAWalker2_validate -0.230489200796702 1.41605310708363e-08 NA NA NA hsa-miR-142-5p PRKCA 1.88417391525707 1.2096808039882e-27 -1.40949595564765 3.30510040485645e-31 mirMAP -0.203326926537334 1.32429030012509e-07 NA NA NA hsa-miR-146a-5p PRKCA 1.04938133739924 7.51013231709992e-12 -1.40949595564765 3.30510040485645e-31 mirMAP -0.138636449569245 0.00290151925750071 NA NA NA hsa-miR-150-5p PRKCA 1.00371863159681 1.09871676395528e-09 -1.40949595564765 3.30510040485645e-31 mirMAP -0.141463696474327 0.00116284963615584 NA NA NA hsa-miR-17-3p PRKCA 0.723795600017259 5.90151677164931e-18 -1.40949595564765 3.30510040485645e-31 miRNAWalker2_validate -0.55301268177802 1.37146521298911e-11 NA NA NA hsa-miR-181a-5p PRKCA 1.11111114875339 3.97880443756442e-29 -1.40949595564765 3.30510040485645e-31 mirMAP -0.540264161188695 1.18526956498458e-16 NA NA NA hsa-miR-181b-5p PRKCA 1.49054296272357 3.69051660739368e-41 -1.40949595564765 3.30510040485645e-31 mirMAP -0.473733908349652 2.1676855775351e-17 NA NA NA hsa-miR-181c-5p PRKCA 0.762784646696248 4.48373118147729e-10 -1.40949595564765 3.30510040485645e-31 mirMAP -0.256287812602341 1.11910895047438e-05 NA NA NA hsa-miR-186-5p PRKCA 0.507217561043443 9.04455748270995e-10 -1.40949595564765 3.30510040485645e-31 miRNATAP -0.239864584666343 0.00624473839846306 NA NA NA hsa-miR-19b-1-5p PRKCA 0.66692013055553 1.55789130176287e-09 -1.40949595564765 3.30510040485645e-31 mirMAP -0.193605809138291 0.00310670883960429 NA NA NA hsa-miR-224-5p PRKCA 2.84654230414912 3.0480927226395e-47 -1.40949595564765 3.30510040485645e-31 mirMAP -0.224468346181721 5.75169704731423e-13 NA NA NA hsa-miR-2355-3p PRKCA 1.32757890426926 1.88016636795886e-18 -1.40949595564765 3.30510040485645e-31 mirMAP -0.261610517007587 1.83229270594567e-08 NA NA NA hsa-miR-3170 PRKCA 0.664452094631118 2.78926402033808e-05 -1.40949595564765 3.30510040485645e-31 mirMAP -0.143525555001005 0.00205070350789402 NA NA NA hsa-miR-330-3p PRKCA 0.912906550436308 3.35037014057665e-13 -1.40949595564765 3.30510040485645e-31 mirMAP -0.261128612369017 5.50369517469821e-06 NA NA NA hsa-miR-340-5p PRKCA 1.14479851941741 2.91936881701444e-15 -1.40949595564765 3.30510040485645e-31 mirMAP -0.258076358061294 7.18198801898922e-08 NA NA NA hsa-miR-374a-3p PRKCA 1.13863935833993 2.79089304015401e-44 -1.40949595564765 3.30510040485645e-31 mirMAP -0.684628765839887 6.42429291388675e-20 NA NA NA hsa-miR-374a-5p PRKCA 0.543061152108237 2.19403097299769e-14 -1.40949595564765 3.30510040485645e-31 mirMAP -0.522893225273422 1.47637062832505e-07 NA NA NA hsa-miR-452-5p PRKCA 2.05325688842141 2.82238393643084e-40 -1.40949595564765 3.30510040485645e-31 mirMAP -0.33224472833984 1.34300342334138e-16 NA NA NA hsa-miR-590-3p PRKCA 1.13702599385212 3.53435739887793e-22 -1.40949595564765 3.30510040485645e-31 PITA;miRanda;mirMAP;miRNATAP -0.332392461839564 9.25847276505916e-09 NA NA NA hsa-miR-592 PRKCA 2.6404220268798 8.81369998128794e-32 -1.40949595564765 3.30510040485645e-31 miRNATAP -0.172568846986646 3.52884206079864e-09 NA NA NA hsa-miR-200b-3p PRKCB -1.70383252137161 2.38979336321755e-30 0.583904117599654 0.000239395825023428 MirTarget -0.161635318424647 0.00276990701776461 NA NA NA hsa-miR-27b-3p PRKCB -0.699527231242518 1.07356023759234e-15 0.583904117599654 0.000239395825023428 MirTarget;miRNATAP -0.381848642069096 8.29210459175488e-05 NA NA NA hsa-miR-30a-3p PRKCB -0.955360819934585 1.97009535429185e-20 0.583904117599654 0.000239395825023428 mirMAP -0.27445649163855 0.000675651397734009 NA NA NA hsa-miR-30b-5p PRKCB -1.18330589477119 6.8341618466966e-27 0.583904117599654 0.000239395825023428 mirMAP -0.43302228945984 2.35087485736611e-09 NA NA NA hsa-miR-30c-5p PRKCB -1.08783070774238 2.02505402525786e-24 0.583904117599654 0.000239395825023428 mirMAP -0.200266218821399 0.00954411836448046 NA NA NA hsa-miR-30d-3p PRKCB -0.249777194282131 0.00235356711813496 0.583904117599654 0.000239395825023428 mirMAP -0.527711285390385 8.06872957758744e-07 NA NA NA hsa-miR-30d-5p PRKCB -0.202727675788184 0.00659067084745794 0.583904117599654 0.000239395825023428 mirMAP -0.615678537820375 1.81242737170691e-07 NA NA NA hsa-miR-361-5p PRKCB 0.0514169367202078 0.382929376393199 0.583904117599654 0.000239395825023428 MirTarget;miRanda;miRNATAP -0.499291115851109 0.00117224790143438 NA NA NA hsa-miR-429 PRKCB -2.16569233119434 2.66862243626443e-37 0.583904117599654 0.000239395825023428 MirTarget;miRanda;miRNATAP -0.192274100704377 2.89126645159923e-05 NA NA NA hsa-miR-126-5p PRKX 0.785607261431085 5.77058629454465e-13 -0.824466674997549 1.24178637796187e-14 MirTarget;miRNATAP -0.225620112374926 3.14306953584905e-05 NA NA NA hsa-miR-128-3p PRKX 0.475045893035043 2.6255647468e-06 -0.824466674997549 1.24178637796187e-14 MirTarget -0.354668377255749 1.84548885162361e-09 NA NA NA hsa-miR-140-3p PRKX 0.989350547007025 6.14964028267239e-25 -0.824466674997549 1.24178637796187e-14 mirMAP -0.238393239812655 5.88038969986026e-05 NA NA NA hsa-miR-143-5p PRKX 0.297037599500085 0.0442949119420742 -0.824466674997549 1.24178637796187e-14 miRNATAP -0.112746271955476 0.00680173941413137 NA NA NA hsa-miR-144-3p PRKX 1.4617706700291 9.18139413836375e-11 -0.824466674997549 1.24178637796187e-14 MirTarget -0.13272578965549 3.71142728059944e-07 NA NA NA hsa-miR-148a-3p PRKX 0.343233211643815 0.00402279073598165 -0.824466674997549 1.24178637796187e-14 MirTarget -0.26948947078394 1.06219908024953e-07 NA NA NA hsa-miR-148b-3p PRKX 0.346011252093377 4.27203463315056e-06 -0.824466674997549 1.24178637796187e-14 MirTarget -0.318456532820279 8.82988200529867e-05 NA NA NA hsa-miR-148b-5p PRKX 0.269550343699955 0.0383631776794927 -0.824466674997549 1.24178637796187e-14 mirMAP -0.130567047783336 0.0074991694843521 NA NA NA hsa-miR-16-1-3p PRKX 1.51429140700091 3.17219833254498e-37 -0.824466674997549 1.24178637796187e-14 MirTarget -0.360359060096853 1.04124203973636e-15 NA NA NA hsa-miR-16-2-3p PRKX 1.3046118743965 4.17207934608428e-19 -0.824466674997549 1.24178637796187e-14 MirTarget;mirMAP -0.185239493595492 2.50440890419259e-06 NA NA NA hsa-miR-181a-5p PRKX 1.11111114875339 3.97880443756442e-29 -0.824466674997549 1.24178637796187e-14 mirMAP -0.354450125800361 1.7110841075268e-10 NA NA NA hsa-miR-181b-5p PRKX 1.49054296272357 3.69051660739368e-41 -0.824466674997549 1.24178637796187e-14 mirMAP -0.309398411713712 7.9863573419145e-11 NA NA NA hsa-miR-195-3p PRKX 0.808592887366705 6.8151241038711e-09 -0.824466674997549 1.24178637796187e-14 MirTarget;mirMAP -0.150691727177806 0.000502555427500189 NA NA NA hsa-miR-19a-3p PRKX 0.722913586880779 2.76301458932381e-10 -0.824466674997549 1.24178637796187e-14 miRNATAP -0.145006279305195 0.00566274166698371 NA NA NA hsa-miR-218-5p PRKX -0.81077534785501 3.0631582201951e-08 -0.824466674997549 1.24178637796187e-14 miRNATAP -0.123260848996704 0.002728147543298 NA NA NA hsa-miR-224-5p PRKX 2.84654230414912 3.0480927226395e-47 -0.824466674997549 1.24178637796187e-14 mirMAP -0.102297987942287 0.000128251231211549 NA NA NA hsa-miR-23a-3p PRKX 0.761438723382355 4.09310879199257e-27 -0.824466674997549 1.24178637796187e-14 mirMAP -0.324733496416332 5.67635968371776e-05 NA NA NA hsa-miR-27a-3p PRKX 0.558934437526245 1.44256383086177e-12 -0.824466674997549 1.24178637796187e-14 MirTarget;miRNATAP -0.250273883699444 0.000969807865024322 NA NA NA hsa-miR-29c-3p PRKX -0.238671318446745 0.0141475322347596 -0.824466674997549 1.24178637796187e-14 mirMAP -0.174256475739199 0.00607897894760014 NA NA NA hsa-miR-330-3p PRKX 0.912906550436308 3.35037014057665e-13 -0.824466674997549 1.24178637796187e-14 MirTarget -0.212099933368802 9.66208692931154e-06 NA NA NA hsa-miR-374a-3p PRKX 1.13863935833993 2.79089304015401e-44 -0.824466674997549 1.24178637796187e-14 mirMAP -0.39192911160223 1.37147903262365e-09 NA NA NA hsa-miR-421 PRKX 0.313155739887734 0.020433534776003 -0.824466674997549 1.24178637796187e-14 miRanda -0.209773371514651 6.65889163437683e-06 NA NA NA hsa-miR-576-5p PRKX 1.06681109513983 5.69294424466526e-24 -0.824466674997549 1.24178637796187e-14 mirMAP -0.187960886178378 0.000516056334679525 NA NA NA hsa-miR-590-3p PRKX 1.13702599385212 3.53435739887793e-22 -0.824466674997549 1.24178637796187e-14 mirMAP -0.299538297188508 4.45201426482462e-10 NA NA NA hsa-miR-625-3p PRKX 1.09679549288964 4.60800634006165e-20 -0.824466674997549 1.24178637796187e-14 mirMAP -0.135091209992979 0.00538503960183476 NA NA NA hsa-miR-616-5p PTPN5 0.913426384742148 3.78418389333709e-09 0.121238387929123 0.681738111414474 miRNATAP -0.275976041969196 0.00820388312129026 NA NA NA hsa-miR-10b-3p PTPN7 -0.8205021989966 7.84331443044781e-21 1.92198850968161 1.21832321163533e-20 MirTarget -0.912075161420712 5.86860189272797e-13 NA NA NA hsa-miR-125a-3p PTPN7 -0.372794471295036 0.000941729459601642 1.92198850968161 1.21832321163533e-20 miRanda -0.308858581816962 0.00408127675620263 NA NA NA hsa-miR-335-5p PTPN7 -2.09515619961552 1.03765771499548e-25 1.92198850968161 1.21832321163533e-20 miRNAWalker2_validate -0.203133854410654 0.000311410942359244 NA NA NA hsa-miR-188-5p PTPRR -1.74586655806628 1.50431624674552e-28 1.08277651605957 5.20204472589646e-08 MirTarget;PITA -0.353263707252923 9.09773761465836e-08 NA NA NA hsa-miR-30a-3p PTPRR -0.955360819934585 1.97009535429185e-20 1.08277651605957 5.20204472589646e-08 MirTarget -0.36091005198226 0.000414907658046319 NA NA NA hsa-miR-429 PTPRR -2.16569233119434 2.66862243626443e-37 1.08277651605957 5.20204472589646e-08 miRanda -0.271308258097824 2.97270696825509e-06 NA NA NA hsa-miR-342-3p RAC3 1.4124432570595 1.07208971556131e-28 -1.40504132869683 4.24492750834751e-13 miRanda -0.303985376974766 0.000136219209735901 NA NA NA hsa-miR-146b-3p RAF1 1.20941495066078 2.12939149602665e-10 -0.729326295365523 1.03493473489106e-42 MirTarget;PITA;miRNATAP -0.126960331865385 9.60010767311038e-15 NA NA NA hsa-miR-15a-5p RAF1 1.42663930007845 1.36006952074963e-57 -0.729326295365523 1.03493473489106e-42 MirTarget;miRNATAP -0.324293625748972 2.12345656575569e-29 NA NA NA hsa-miR-15b-5p RAF1 0.773001494057531 1.71784656078957e-16 -0.729326295365523 1.03493473489106e-42 MirTarget;miRNATAP -0.217283143578276 6.68293363881507e-11 NA NA NA hsa-miR-16-5p RAF1 0.934012514027655 4.85417898318515e-24 -0.729326295365523 1.03493473489106e-42 MirTarget;miRNATAP -0.2832583907681 1.12454604973701e-18 26527888 Besides we identify that Raf1 is a direct target of miR-15a/b miR-16 and miR-195 by dual luciferase reporter assay thyroid cancer hsa-miR-186-5p RAF1 0.507217561043443 9.04455748270995e-10 -0.729326295365523 1.03493473489106e-42 miRNAWalker2_validate -0.248932939680122 1.31766215047697e-10 NA NA NA hsa-miR-195-5p RAF1 0.346502644882604 0.0092562828415903 -0.729326295365523 1.03493473489106e-42 miRTarBase;MirTarget;miRNATAP -0.106749755319653 1.79108008549216e-05 26527888;21350001;27153315;23760062 miR 195 is a key regulator of Raf1 in thyroid cancer; Besides we identify that Raf1 is a direct target of miR-15a/b miR-16 and miR-195 by dual luciferase reporter assay; Furthermore exogenous overexpression of miR-195 significantly inhibits the protein expression of Raf1 and blocks the thyroid cancer cell proliferation;Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer;IGF2BP2 promotes colorectal cancer cell proliferation and survival through interfering with RAF 1 degradation by miR 195; Molecular function analyses revealed that IGF2BP2 regulates RAF1 expression through blocking its degradation by miR-195;Upregulation of miR 195 increases the sensitivity of breast cancer cells to Adriamycin treatment through inhibition of Raf 1; The data showed that miR-195 expression was low in breast cancer cells and multidrug-resistant breast cancer tissues which was associated with reduced Raf-1 expression in vitro and ex vivo; Induction of miR-195 expression promoted tumor cell apoptosis and inhibited breast cancer cell viability but induced the sensitivity of breast cancer cells to Adriamycin treatment and was associated with inhibition of Raf-1 expression in breast cancer cells; Moreover knockdown of Raf-1 expression had similar effects of miR-195 mimics on breast cancer cells both of which were able to suppress Bcl-2 and P-glycoprotein expression in breast cancer cells; The data from the current study demonstrated that expression of miR-195 was inversely associated with Raf-1 expression in breast cancer cell lines and tissue specimens and that Raf-1 is the target gene of miR-195 ;;poor survival; thyroid cancer;breast cancer;colorectal cancer;breast cancer hsa-miR-19a-3p RAF1 0.722913586880779 2.76301458932381e-10 -0.729326295365523 1.03493473489106e-42 MirTarget;miRNATAP -0.154284306170029 3.61502307447547e-08 NA NA NA hsa-miR-19b-3p RAF1 0.195940928879427 0.0300512922542325 -0.729326295365523 1.03493473489106e-42 MirTarget;miRNATAP -0.115125075816159 0.00199179078014951 NA NA NA hsa-miR-331-3p RAF1 0.431607034018882 6.83022920590941e-05 -0.729326295365523 1.03493473489106e-42 MirTarget;miRNATAP -0.158262304030351 1.65741452145876e-07 NA NA NA hsa-miR-484 RAF1 0.571987778099603 9.67278224458421e-10 -0.729326295365523 1.03493473489106e-42 MirTarget -0.240322437451901 1.50205113397331e-12 NA NA NA hsa-miR-497-5p RAF1 0.227757383708836 0.0600073987853074 -0.729326295365523 1.03493473489106e-42 miRTarBase;MirTarget;miRNATAP -0.119677885863477 1.30076085946277e-05 21350001 Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer breast cancer hsa-miR-590-3p RAF1 1.13702599385212 3.53435739887793e-22 -0.729326295365523 1.03493473489106e-42 miRanda -0.179633605652733 4.3114164233555e-12 NA NA NA hsa-miR-93-3p RAF1 0.379664250785728 9.76327751780657e-05 -0.729326295365523 1.03493473489106e-42 miRNATAP -0.192339109650426 1.01632622523622e-08 NA NA NA hsa-miR-942-5p RAF1 0.978672610596303 3.12802933163696e-12 -0.729326295365523 1.03493473489106e-42 MirTarget -0.130737374750736 7.69722175616835e-09 NA NA NA hsa-miR-101-5p RAP1B -0.710089604234471 1.19159750684491e-09 0.286208775671425 7.37540638959961e-08 MirTarget -0.109458505991147 9.08978722827426e-06 24697700 Functional analysis of miR 101 3p and Rap1b involved in hepatitis B virus related hepatocellular carcinoma pathogenesis liver cancer hsa-miR-27b-3p RAP1B -0.699527231242518 1.07356023759234e-15 0.286208775671425 7.37540638959961e-08 MirTarget -0.176368695618954 4.57827183852651e-08 NA NA NA hsa-miR-30a-5p RAP1B -0.778411951775343 2.73322451127932e-16 0.286208775671425 7.37540638959961e-08 MirTarget;miRNATAP -0.157900294407933 8.71698303133625e-08 NA NA NA hsa-miR-30b-5p RAP1B -1.18330589477119 6.8341618466966e-27 0.286208775671425 7.37540638959961e-08 MirTarget -0.116076136600269 2.44395548782544e-06 NA NA NA hsa-miR-30c-5p RAP1B -1.08783070774238 2.02505402525786e-24 0.286208775671425 7.37540638959961e-08 MirTarget;miRNATAP -0.107723639556347 2.89701994201079e-05 NA NA NA hsa-miR-30d-5p RAP1B -0.202727675788184 0.00659067084745794 0.286208775671425 7.37540638959961e-08 MirTarget;miRNATAP -0.149796748802348 0.000185581330380838 NA NA NA hsa-miR-106a-5p RAPGEF2 -0.830908656792615 2.67547872901508e-10 0.257118292682138 0.00311796201950167 MirTarget;miRNATAP -0.137354933670238 0.000105829238871902 NA NA NA hsa-miR-106b-5p RAPGEF2 1.07509411417907 2.11739194181878e-36 0.257118292682138 0.00311796201950167 MirTarget;miRNATAP -0.17370167339893 0.000586113531104199 NA NA NA hsa-miR-149-5p RAPGEF2 -1.95790336710741 8.46371715052367e-27 0.257118292682138 0.00311796201950167 miRNAWalker2_validate -0.160220392774287 1.03342096120273e-11 NA NA NA hsa-miR-193a-3p RAPGEF2 0.849206638484406 3.68101781083335e-14 0.257118292682138 0.00311796201950167 miRanda -0.169988847038492 3.54725082959381e-05 NA NA NA hsa-miR-19b-3p RAPGEF2 0.195940928879427 0.0300512922542325 0.257118292682138 0.00311796201950167 MirTarget;miRNATAP -0.220282506341214 3.5345013401841e-05 NA NA NA hsa-miR-24-3p RAPGEF2 0.173813044685099 0.00565259443420961 0.257118292682138 0.00311796201950167 MirTarget;miRNATAP -0.248651940248025 0.00140161013493328 NA NA NA hsa-miR-335-3p RAPGEF2 -1.36498175550207 6.84287752180534e-13 0.257118292682138 0.00311796201950167 mirMAP -0.121782308832049 4.30981352064229e-07 NA NA NA hsa-miR-335-5p RAPGEF2 -2.09515619961552 1.03765771499548e-25 0.257118292682138 0.00311796201950167 miRNAWalker2_validate -0.126920471154976 8.01257131025073e-09 NA NA NA hsa-miR-339-5p RAPGEF2 0.322848334531193 0.0117281778821612 0.257118292682138 0.00311796201950167 MirTarget;PITA -0.211934019304515 8.62461175143465e-09 NA NA NA hsa-miR-379-5p RAPGEF2 -0.844571840578256 4.56275837943769e-06 0.257118292682138 0.00311796201950167 miRNATAP -0.10596439250984 3.35811489182769e-05 NA NA NA hsa-miR-615-3p RAPGEF2 -0.777370544471479 2.08193713560545e-08 0.257118292682138 0.00311796201950167 miRNAWalker2_validate -0.103369381481096 0.00232984600974382 NA NA NA hsa-miR-24-3p RASA1 0.173813044685099 0.00565259443420961 0.0217286156818641 0.75657862415223 MirTarget;miRNATAP -0.320385426359283 1.81314237484709e-07 NA NA NA hsa-miR-26a-5p RASA1 -0.202091714279613 0.00166918288801054 0.0217286156818641 0.75657862415223 miRNAWalker2_validate -0.182327992810041 0.00264769232284362 NA NA NA hsa-miR-30b-5p RASA1 -1.18330589477119 6.8341618466966e-27 0.0217286156818641 0.75657862415223 MirTarget -0.128210708164226 6.18645358602785e-05 NA NA NA hsa-miR-30b-5p RASA2 -1.18330589477119 6.8341618466966e-27 -0.155624188098594 0.195395998553973 mirMAP -0.177814784836538 0.00131875058405262 NA NA NA hsa-miR-106b-5p RASGRF2 1.07509411417907 2.11739194181878e-36 -0.161186180108779 0.261117228287715 MirTarget -0.40247570153502 9.83767139579981e-07 NA NA NA hsa-miR-146b-5p RASGRF2 1.40714170253819 2.9559871816487e-12 -0.161186180108779 0.261117228287715 miRanda -0.196529611245711 1.31111712072467e-07 NA NA NA hsa-miR-17-5p RASGRF2 0.494260110870015 3.8348005261e-09 -0.161186180108779 0.261117228287715 MirTarget;TargetScan -0.271656502011799 0.00342072931959185 NA NA NA hsa-miR-182-5p RASGRF2 -0.608710746044567 0.0025264935278104 -0.161186180108779 0.261117228287715 mirMAP -0.171751087687878 8.67724615166908e-06 NA NA NA hsa-miR-28-5p RASGRF2 0.461962042257226 3.32424690573327e-11 -0.161186180108779 0.261117228287715 miRanda -0.409446533227333 0.000232341243378579 NA NA NA hsa-miR-421 RASGRF2 0.313155739887734 0.020433534776003 -0.161186180108779 0.261117228287715 miRanda;mirMAP -0.18846514780393 0.00178172434768131 NA NA NA hsa-miR-590-3p RASGRF2 1.13702599385212 3.53435739887793e-22 -0.161186180108779 0.261117228287715 MirTarget;miRanda -0.205219058897356 0.00113417568115945 NA NA NA hsa-miR-590-5p RASGRF2 0.709763558412506 1.11883921359361e-11 -0.161186180108779 0.261117228287715 miRanda -0.19856058327869 0.00695333530181574 NA NA NA hsa-miR-664a-3p RASGRF2 -0.019312777079624 0.825861598748857 -0.161186180108779 0.261117228287715 mirMAP -0.247653262246371 0.00655023804824046 NA NA NA hsa-miR-93-5p RASGRF2 1.37365940377595 2.37567548683245e-46 -0.161186180108779 0.261117228287715 MirTarget -0.205862485013484 0.00393310909917406 NA NA NA hsa-miR-221-3p RASGRP1 0.337895669520713 0.0136448974691037 -0.16513553750872 0.228493491156229 MirTarget -0.228029513724262 3.05823699260709e-05 NA NA NA hsa-miR-2355-3p RASGRP1 1.32757890426926 1.88016636795886e-18 -0.16513553750872 0.228493491156229 MirTarget -0.181112949286381 0.000174129414860136 NA NA NA hsa-miR-324-3p RASGRP2 -0.197662887871899 0.0298845059559819 0.898317692830448 5.31223171890133e-10 PITA -0.358794785893776 7.13151243987706e-05 NA NA NA hsa-miR-199a-5p RASGRP3 -1.64658415208633 1.01615659358973e-23 1.00655968098869 8.4255907167779e-28 miRanda -0.135668029138639 1.28544339252798e-05 NA NA NA hsa-miR-199b-5p RASGRP3 -2.39483476763681 1.04659509514884e-17 1.00655968098869 8.4255907167779e-28 miRanda -0.136039714409104 2.1046829766018e-13 NA NA NA hsa-miR-362-3p RASGRP3 -0.753214251798232 3.0025661608035e-07 1.00655968098869 8.4255907167779e-28 miRanda -0.18918287165185 5.17882895854091e-07 NA NA NA hsa-miR-589-3p RASGRP3 -0.0184909376114044 0.903149951095234 1.00655968098869 8.4255907167779e-28 mirMAP -0.118420434580306 0.00143733546029292 NA NA NA hsa-miR-30b-3p RASGRP4 -1.64703050862226 1.89878531036464e-31 2.06336765912974 4.01956478625706e-40 MirTarget -0.560900719729812 3.08136423056342e-21 NA NA NA hsa-miR-577 RASGRP4 -1.48881999472397 7.03080165111147e-10 2.06336765912974 4.01956478625706e-40 miRNATAP -0.244791285106805 1.99817241505552e-10 NA NA NA hsa-miR-30e-5p RELA -0.0905907245198101 0.21196704484334 0.305834629484614 4.05322273913174e-11 miRNAWalker2_validate -0.103369294516701 0.00471206012122476 NA NA NA hsa-miR-125a-5p RPS6KA1 -0.561874059994802 7.3931856356891e-13 -0.433399736446167 2.70094734091811e-08 MirTarget;PITA;miRanda -0.143926345210058 0.00836948308852458 NA NA NA hsa-miR-20a-5p RPS6KA1 0.702602695798242 4.06372887613329e-13 -0.433399736446167 2.70094734091811e-08 miRNATAP -0.142778602196398 0.00110068159758392 NA NA NA hsa-miR-330-5p RPS6KA1 1.44960468659754 2.12131210588035e-45 -0.433399736446167 2.70094734091811e-08 miRanda -0.100083238991652 0.00716514477264792 NA NA NA hsa-miR-93-5p RPS6KA1 1.37365940377595 2.37567548683245e-46 -0.433399736446167 2.70094734091811e-08 miRNATAP -0.136988620554412 0.000519864798722955 NA NA NA hsa-miR-130b-5p RPS6KA2 0.92990617673277 3.75880436852717e-12 -0.212211114338083 0.0475241240943583 mirMAP -0.177208577567739 2.9086708991819e-05 NA NA NA hsa-miR-17-5p RPS6KA2 0.494260110870015 3.8348005261e-09 -0.212211114338083 0.0475241240943583 TargetScan -0.223467482842844 0.00125580166887693 NA NA NA hsa-miR-185-3p RPS6KA2 0.993379985307475 2.62011454953707e-13 -0.212211114338083 0.0475241240943583 MirTarget -0.172188563819846 4.57331956946955e-05 NA NA NA hsa-miR-193b-3p RPS6KA2 -0.273325765316079 0.104328826585392 -0.212211114338083 0.0475241240943583 mirMAP -0.254245075710105 5.62254173997602e-14 NA NA NA hsa-miR-19a-3p RPS6KA2 0.722913586880779 2.76301458932381e-10 -0.212211114338083 0.0475241240943583 MirTarget -0.146854125264348 0.00350582708389517 NA NA NA hsa-miR-21-3p RPS6KA2 1.78837590049697 1.41655409877312e-33 -0.212211114338083 0.0475241240943583 MirTarget -0.131230323868777 0.000243180115333484 NA NA NA hsa-miR-3127-5p RPS6KA2 0.952801473575318 5.81162987769266e-14 -0.212211114338083 0.0475241240943583 mirMAP -0.130757843393535 0.00506553280635018 NA NA NA hsa-miR-378a-3p RPS6KA2 0.287244802401236 0.0501155019984562 -0.212211114338083 0.0475241240943583 MirTarget -0.249486334772224 2.18584952163243e-10 NA NA NA hsa-miR-378c RPS6KA2 0.755048315231594 3.56147090439556e-06 -0.212211114338083 0.0475241240943583 MirTarget -0.176896357089749 6.79794300094522e-07 NA NA NA hsa-miR-589-5p RPS6KA2 0.696241532021631 5.26958362886071e-16 -0.212211114338083 0.0475241240943583 mirMAP -0.366271008637334 1.72508460204289e-08 NA NA NA hsa-miR-106b-5p RPS6KA3 1.07509411417907 2.11739194181878e-36 -0.0569263656430596 0.481222370733631 miRNATAP -0.153826494720885 0.00097792160434743 NA NA NA hsa-miR-181c-5p RPS6KA3 0.762784646696248 4.48373118147729e-10 -0.0569263656430596 0.481222370733631 MirTarget;mirMAP;miRNATAP -0.101641507041936 0.00409231381726318 NA NA NA hsa-miR-363-3p RPS6KA4 -1.93551166555337 4.45368477487614e-32 0.571305054593926 4.412641535984e-15 MirTarget -0.102088987404786 8.2393764749968e-06 NA NA NA hsa-miR-106b-5p RPS6KA5 1.07509411417907 2.11739194181878e-36 -0.524687913716405 9.16547275577838e-07 MirTarget -0.408363675899646 2.79452612966452e-11 NA NA NA hsa-miR-107 RPS6KA5 0.140046250553248 0.0943611632552367 -0.524687913716405 9.16547275577838e-07 miRanda -0.355669952040441 6.17781498204591e-07 NA NA NA hsa-miR-128-3p RPS6KA5 0.475045893035043 2.6255647468e-06 -0.524687913716405 9.16547275577838e-07 miRNAWalker2_validate;MirTarget -0.233102379663276 6.43223297079214e-05 NA NA NA hsa-miR-130b-3p RPS6KA5 1.12788913578446 2.939369462276e-16 -0.524687913716405 9.16547275577838e-07 MirTarget -0.18859838807281 4.39088660454195e-06 NA NA NA hsa-miR-142-5p RPS6KA5 1.88417391525707 1.2096808039882e-27 -0.524687913716405 9.16547275577838e-07 MirTarget;PITA;mirMAP;miRNATAP -0.123475394256131 9.21719556242586e-05 NA NA NA hsa-miR-152-3p RPS6KA5 0.187079360533734 0.052276214844753 -0.524687913716405 9.16547275577838e-07 MirTarget -0.29127635627813 2.45834582206198e-06 NA NA NA hsa-miR-18a-5p RPS6KA5 0.936704393213466 1.05064580570579e-10 -0.524687913716405 9.16547275577838e-07 MirTarget -0.194891810783998 8.74035180397566e-07 NA NA NA hsa-miR-27a-3p RPS6KA5 0.558934437526245 1.44256383086177e-12 -0.524687913716405 9.16547275577838e-07 miRNAWalker2_validate;MirTarget;miRNATAP -0.265273919142115 0.000320796661632922 NA NA NA hsa-miR-28-5p RPS6KA5 0.461962042257226 3.32424690573327e-11 -0.524687913716405 9.16547275577838e-07 miRanda -0.406566848558933 1.16506436493846e-06 NA NA NA hsa-miR-331-5p RPS6KA5 0.661186030542026 1.83628790002785e-08 -0.524687913716405 9.16547275577838e-07 PITA -0.219873044420029 2.16644774476384e-05 NA NA NA hsa-miR-342-3p RPS6KA5 1.4124432570595 1.07208971556131e-28 -0.524687913716405 9.16547275577838e-07 PITA;miRanda;miRNATAP -0.116263924077993 0.00709954259671371 NA NA NA hsa-miR-421 RPS6KA5 0.313155739887734 0.020433534776003 -0.524687913716405 9.16547275577838e-07 miRanda -0.12392648125523 0.00680035867884612 NA NA NA hsa-miR-590-3p RPS6KA5 1.13702599385212 3.53435739887793e-22 -0.524687913716405 9.16547275577838e-07 miRanda -0.231485620338418 9.79452844893123e-07 NA NA NA hsa-miR-93-5p RPS6KA5 1.37365940377595 2.37567548683245e-46 -0.524687913716405 9.16547275577838e-07 miRNAWalker2_validate;MirTarget -0.182409842823443 0.000724274657700497 NA NA NA hsa-miR-1271-5p RPS6KA6 0.900599702972936 3.07963385418853e-10 -5.02319609647308 2.00514288352531e-35 MirTarget -0.526970657354953 0.00189389477393479 NA NA NA hsa-miR-15a-5p RPS6KA6 1.42663930007845 1.36006952074963e-57 -5.02319609647308 2.00514288352531e-35 MirTarget -2.53085785588334 1.26093387994038e-32 NA NA NA hsa-miR-15b-5p RPS6KA6 0.773001494057531 1.71784656078957e-16 -5.02319609647308 2.00514288352531e-35 MirTarget -1.99934410555447 2.48804031191179e-16 NA NA NA hsa-miR-16-5p RPS6KA6 0.934012514027655 4.85417898318515e-24 -5.02319609647308 2.00514288352531e-35 MirTarget -2.16602770116441 1.23379955733856e-19 NA NA NA hsa-miR-17-5p RPS6KA6 0.494260110870015 3.8348005261e-09 -5.02319609647308 2.00514288352531e-35 TargetScan -1.69854589208916 3.39759866761013e-09 NA NA NA hsa-miR-192-3p RPS6KA6 0.156650099616707 0.483496040900362 -5.02319609647308 2.00514288352531e-35 MirTarget -0.33484926706264 0.00285293688546284 NA NA NA hsa-miR-195-5p RPS6KA6 0.346502644882604 0.0092562828415903 -5.02319609647308 2.00514288352531e-35 MirTarget -0.745611028885755 6.17026051423213e-05 NA NA NA hsa-miR-19a-3p RPS6KA6 0.722913586880779 2.76301458932381e-10 -5.02319609647308 2.00514288352531e-35 MirTarget -1.30081845054165 3.7558599964014e-10 NA NA NA hsa-miR-19b-3p RPS6KA6 0.195940928879427 0.0300512922542325 -5.02319609647308 2.00514288352531e-35 MirTarget -1.21825669990333 1.00629204767186e-05 NA NA NA hsa-miR-374a-5p RPS6KA6 0.543061152108237 2.19403097299769e-14 -5.02319609647308 2.00514288352531e-35 MirTarget -1.94743185919819 6.17504231911122e-09 NA NA NA hsa-miR-374b-3p RPS6KA6 0.611842481331529 3.85718194756943e-07 -5.02319609647308 2.00514288352531e-35 MirTarget -0.740672664375455 0.000438072946812851 NA NA NA hsa-miR-497-5p RPS6KA6 0.227757383708836 0.0600073987853074 -5.02319609647308 2.00514288352531e-35 MirTarget -0.624919365272913 0.00247184613892212 NA NA NA hsa-miR-590-3p RPS6KA6 1.13702599385212 3.53435739887793e-22 -5.02319609647308 2.00514288352531e-35 MirTarget;miRanda;mirMAP;miRNATAP -1.66662709717755 1.36127745738836e-18 NA NA NA hsa-miR-106b-5p RRAS2 1.07509411417907 2.11739194181878e-36 -0.44234311736897 6.43194882105622e-09 miRNATAP -0.124383561814842 0.00594749690734943 NA NA NA hsa-miR-140-3p RRAS2 0.989350547007025 6.14964028267239e-25 -0.44234311736897 6.43194882105622e-09 MirTarget;PITA;miRNATAP -0.245191563810215 1.8200293337363e-09 NA NA NA hsa-miR-20a-5p RRAS2 0.702602695798242 4.06372887613329e-13 -0.44234311736897 6.43194882105622e-09 miRNATAP -0.170571071949194 6.41677814266269e-05 NA NA NA hsa-miR-23a-3p RRAS2 0.761438723382355 4.09310879199257e-27 -0.44234311736897 6.43194882105622e-09 MirTarget;miRNATAP -0.206152149089032 0.00025734992372647 NA NA NA hsa-miR-320a RRAS2 0.412740558379182 2.02929519701706e-05 -0.44234311736897 6.43194882105622e-09 miRanda -0.117093853573067 0.00795461126952592 NA NA NA hsa-miR-93-5p RRAS2 1.37365940377595 2.37567548683245e-46 -0.44234311736897 6.43194882105622e-09 miRNAWalker2_validate -0.146914012234231 0.000140590207004362 NA NA NA hsa-miR-22-5p SOS1 -0.197038086012602 0.106234828461117 0.165657937822672 0.00695508624793917 miRNATAP -0.1259671249937 4.71993758199897e-06 NA NA NA hsa-miR-27b-3p SOS1 -0.699527231242518 1.07356023759234e-15 0.165657937822672 0.00695508624793917 MirTarget;miRNATAP -0.147080230611449 7.31565228121447e-05 NA NA NA hsa-miR-30b-5p SOS1 -1.18330589477119 6.8341618466966e-27 0.165657937822672 0.00695508624793917 mirMAP -0.138149072736721 7.79904823834726e-07 NA NA NA hsa-miR-361-5p SOS1 0.0514169367202078 0.382929376393199 0.165657937822672 0.00695508624793917 miRanda -0.17245343753156 0.00341644954529283 NA NA NA hsa-miR-130b-3p SOS2 1.12788913578446 2.939369462276e-16 -0.603803978860436 7.13914474388309e-16 miRNATAP -0.219389641555847 2.49951089457902e-14 NA NA NA hsa-miR-146b-5p SOS2 1.40714170253819 2.9559871816487e-12 -0.603803978860436 7.13914474388309e-16 miRanda -0.147776164302161 1.19506749629666e-13 NA NA NA hsa-miR-15a-5p SOS2 1.42663930007845 1.36006952074963e-57 -0.603803978860436 7.13914474388309e-16 miRNATAP -0.253370307078702 1.58238296990946e-10 NA NA NA hsa-miR-15b-5p SOS2 0.773001494057531 1.71784656078957e-16 -0.603803978860436 7.13914474388309e-16 miRNATAP -0.335211578081185 2.30658617778889e-15 NA NA NA hsa-miR-16-5p SOS2 0.934012514027655 4.85417898318515e-24 -0.603803978860436 7.13914474388309e-16 miRNATAP -0.24200816200432 1.67224378158762e-08 NA NA NA hsa-miR-193a-3p SOS2 0.849206638484406 3.68101781083335e-14 -0.603803978860436 7.13914474388309e-16 PITA;miRanda;miRNATAP -0.269886140589803 4.58383896803507e-14 NA NA NA hsa-miR-21-5p SOS2 2.51462371613332 3.30620591950316e-66 -0.603803978860436 7.13914474388309e-16 miRNATAP -0.237021856922544 1.01167070366515e-26 NA NA NA hsa-miR-301a-3p SOS2 0.259400847075798 0.0216890736701418 -0.603803978860436 7.13914474388309e-16 miRNATAP -0.116740679991895 0.00226202627325341 NA NA NA hsa-miR-320a SOS2 0.412740558379182 2.02929519701706e-05 -0.603803978860436 7.13914474388309e-16 miRanda;miRNATAP -0.205432651949533 2.81576440891282e-06 NA NA NA hsa-miR-320b SOS2 0.300497419754843 0.0245219177384172 -0.603803978860436 7.13914474388309e-16 miRanda;miRNATAP -0.152878780959194 1.68250949578106e-06 NA NA NA hsa-miR-454-3p SOS2 0.68285296887698 1.17407812677787e-08 -0.603803978860436 7.13914474388309e-16 miRNATAP -0.1714669429965 9.02571972797797e-07 NA NA NA hsa-miR-590-3p SOS2 1.13702599385212 3.53435739887793e-22 -0.603803978860436 7.13914474388309e-16 miRanda;mirMAP -0.229417057761137 7.37633999411141e-12 NA NA NA hsa-miR-590-5p SOS2 0.709763558412506 1.11883921359361e-11 -0.603803978860436 7.13914474388309e-16 PITA;miRanda;miRNATAP -0.223093386542166 1.51960822756839e-08 NA NA NA hsa-miR-1976 SRF 0.343475600930938 0.000360243844871748 0.0819836984569005 0.359642649488868 mirMAP -0.154027119270723 0.00253927393846877 NA NA NA hsa-miR-29a-5p SRF -0.519003718107105 1.03351148282116e-06 0.0819836984569005 0.359642649488868 mirMAP -0.133706227470386 0.00349306208927298 NA NA NA hsa-miR-140-5p STK3 0.504309496243674 3.09884038729031e-11 -0.540359724243562 2.30136904058358e-19 PITA;miRanda -0.159340764921247 0.000404919787031997 NA NA NA hsa-miR-28-3p STK3 1.01277915413238 1.8655970171461e-43 -0.540359724243562 2.30136904058358e-19 MirTarget;PITA -0.198020481982223 1.94817986558897e-06 NA NA NA hsa-miR-342-3p STK3 1.4124432570595 1.07208971556131e-28 -0.540359724243562 2.30136904058358e-19 miRanda -0.12033810280856 1.36505230755684e-06 NA NA NA hsa-miR-130a-3p STK4 -0.667386596699886 1.34029167767774e-10 0.812587681451308 9.24559425127492e-33 MirTarget;mirMAP -0.150595146243729 0.000105265135826938 NA NA NA hsa-miR-139-5p STK4 -0.704802495091118 2.36904108453776e-06 0.812587681451308 9.24559425127492e-33 miRanda -0.167272662538038 4.28071599198894e-10 NA NA NA hsa-miR-199a-5p STK4 -1.64658415208633 1.01615659358973e-23 0.812587681451308 9.24559425127492e-33 MirTarget;PITA;miRanda;miRNATAP -0.104969524328074 6.82040198362499e-06 NA NA NA hsa-miR-200a-5p STK4 -1.36295040293874 1.31587720312419e-22 0.812587681451308 9.24559425127492e-33 MirTarget -0.183794923274184 1.11662460725027e-11 NA NA NA hsa-miR-200b-3p STK4 -1.70383252137161 2.38979336321755e-30 0.812587681451308 9.24559425127492e-33 MirTarget -0.211400064540612 1.88154390793387e-18 NA NA NA hsa-miR-200b-5p STK4 -1.46985752435972 3.43232443788022e-27 0.812587681451308 9.24559425127492e-33 MirTarget -0.203110608289506 9.84387964390789e-14 NA NA NA hsa-miR-200c-3p STK4 -5.40303134829523 2.74173143360645e-94 0.812587681451308 9.24559425127492e-33 MirTarget -0.112899861655554 1.39768123125122e-24 NA NA NA hsa-miR-23b-3p STK4 -0.533749586990474 2.46924776953771e-10 0.812587681451308 9.24559425127492e-33 MirTarget;miRNATAP -0.260460395571831 4.34542494357977e-08 NA NA NA hsa-miR-3065-3p STK4 -1.64500070417457 9.57561660036697e-16 0.812587681451308 9.24559425127492e-33 miRNATAP -0.130463352401494 3.53260050857078e-12 NA NA NA hsa-miR-30a-3p STK4 -0.955360819934585 1.97009535429185e-20 0.812587681451308 9.24559425127492e-33 mirMAP -0.340407888136901 1.73194936770955e-21 NA NA NA hsa-miR-30b-3p STK4 -1.64703050862226 1.89878531036464e-31 0.812587681451308 9.24559425127492e-33 MirTarget -0.235606196500993 1.40891013553816e-20 NA NA NA hsa-miR-30b-5p STK4 -1.18330589477119 6.8341618466966e-27 0.812587681451308 9.24559425127492e-33 mirMAP -0.306506286975994 8.96305672286683e-21 NA NA NA hsa-miR-30c-2-3p STK4 -1.28402709024345 6.77577627955178e-25 0.812587681451308 9.24559425127492e-33 MirTarget -0.354458666348077 6.80043237079793e-38 NA NA NA hsa-miR-30c-5p STK4 -1.08783070774238 2.02505402525786e-24 0.812587681451308 9.24559425127492e-33 mirMAP -0.285074522756459 2.0296965155174e-16 NA NA NA hsa-miR-30d-3p STK4 -0.249777194282131 0.00235356711813496 0.812587681451308 9.24559425127492e-33 mirMAP -0.322860692759468 7.48372429238388e-11 NA NA NA hsa-miR-30d-5p STK4 -0.202727675788184 0.00659067084745794 0.812587681451308 9.24559425127492e-33 mirMAP -0.268736756279182 1.35864047556866e-06 NA NA NA hsa-miR-30e-3p STK4 -0.205602546270795 0.00132666419729688 0.812587681451308 9.24559425127492e-33 mirMAP -0.261792966485923 6.33484563047979e-05 NA NA NA hsa-miR-361-5p STK4 0.0514169367202078 0.382929376393199 0.812587681451308 9.24559425127492e-33 mirMAP -0.202892193826623 0.00510831228547249 NA NA NA hsa-miR-362-5p STK4 -2.72767654824605 1.34821749679113e-49 0.812587681451308 9.24559425127492e-33 mirMAP -0.183909199883309 1.04071423214531e-24 NA NA NA hsa-miR-429 STK4 -2.16569233119434 2.66862243626443e-37 0.812587681451308 9.24559425127492e-33 MirTarget;miRanda;miRNATAP -0.200797731102117 5.91117655030092e-23 NA NA NA hsa-miR-500a-5p STK4 -1.28374735824553 1.95870374809798e-20 0.812587681451308 9.24559425127492e-33 MirTarget -0.181990304046837 3.68241449887039e-11 NA NA NA hsa-miR-501-5p STK4 -1.1103073934745 1.81589804886553e-16 0.812587681451308 9.24559425127492e-33 MirTarget;miRNATAP -0.193643595834238 1.18325325383517e-11 NA NA NA hsa-miR-664a-5p STK4 -0.618481839889218 7.01961389909184e-09 0.812587681451308 9.24559425127492e-33 MirTarget -0.140167469776626 0.000227652382392364 NA NA NA hsa-miR-101-3p STMN1 0.683973909682285 2.88573524246948e-15 -0.379239140717412 5.65514332376252e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.352338281577742 2.48839972423566e-12 NA NA NA hsa-miR-107 STMN1 0.140046250553248 0.0943611632552367 -0.379239140717412 5.65514332376252e-06 miRanda -0.172808970302353 0.00210892135772784 NA NA NA hsa-miR-30a-5p STMN1 -0.778411951775343 2.73322451127932e-16 -0.379239140717412 5.65514332376252e-06 miRNAWalker2_validate -0.154925923640725 0.000957095805120043 NA NA NA hsa-miR-338-3p STMN1 0.906250377628867 2.76970900371139e-15 -0.379239140717412 5.65514332376252e-06 miRanda -0.112104832695127 0.00403093086882041 NA NA NA hsa-let-7a-3p TAOK1 0.0677487960013088 0.460458477653989 -0.885269663736398 2.07708545034354e-08 MirTarget;miRNATAP -0.345049251609267 0.000408943202551259 NA NA NA hsa-let-7f-1-3p TAOK1 0.477913872379336 4.46669616865068e-05 -0.885269663736398 2.07708545034354e-08 MirTarget -0.237864593525433 0.00362824005630619 NA NA NA hsa-let-7i-5p TAOK1 0.911372377723717 7.11483853341932e-31 -0.885269663736398 2.07708545034354e-08 miRNATAP -0.374644341348092 0.000279643459302264 NA NA NA hsa-miR-106b-5p TAOK1 1.07509411417907 2.11739194181878e-36 -0.885269663736398 2.07708545034354e-08 miRNATAP -0.767844003266648 7.58735069817086e-18 NA NA NA hsa-miR-130b-3p TAOK1 1.12788913578446 2.939369462276e-16 -0.885269663736398 2.07708545034354e-08 mirMAP -0.329044023676209 5.93300076456951e-08 NA NA NA hsa-miR-130b-5p TAOK1 0.92990617673277 3.75880436852717e-12 -0.885269663736398 2.07708545034354e-08 mirMAP -0.19634980919304 0.00226292072364286 NA NA NA hsa-miR-140-3p TAOK1 0.989350547007025 6.14964028267239e-25 -0.885269663736398 2.07708545034354e-08 mirMAP -0.316713232989481 0.000234008161390274 NA NA NA hsa-miR-148a-5p TAOK1 0.415500302855613 0.000691460831436767 -0.885269663736398 2.07708545034354e-08 mirMAP -0.235690973658393 0.00111259393553611 NA NA NA hsa-miR-15a-5p TAOK1 1.42663930007845 1.36006952074963e-57 -0.885269663736398 2.07708545034354e-08 MirTarget -0.494926040545806 1.58973871788468e-09 NA NA NA hsa-miR-15b-3p TAOK1 1.49422666971434 5.44139893275088e-29 -0.885269663736398 2.07708545034354e-08 mirMAP -0.194753370408959 0.00138935221671725 NA NA NA hsa-miR-15b-5p TAOK1 0.773001494057531 1.71784656078957e-16 -0.885269663736398 2.07708545034354e-08 MirTarget -0.361662710175697 6.37344068157531e-05 NA NA NA hsa-miR-16-5p TAOK1 0.934012514027655 4.85417898318515e-24 -0.885269663736398 2.07708545034354e-08 MirTarget;miRNATAP -0.260344387705761 0.00386067315183018 NA NA NA hsa-miR-17-5p TAOK1 0.494260110870015 3.8348005261e-09 -0.885269663736398 2.07708545034354e-08 TargetScan;miRNATAP -0.292399197067879 0.00520192682481724 NA NA NA hsa-miR-181a-5p TAOK1 1.11111114875339 3.97880443756442e-29 -0.885269663736398 2.07708545034354e-08 mirMAP;miRNATAP -0.349469374144055 1.91655592881862e-05 NA NA NA hsa-miR-181b-5p TAOK1 1.49054296272357 3.69051660739368e-41 -0.885269663736398 2.07708545034354e-08 mirMAP;miRNATAP -0.361913394232753 2.08638734271552e-07 NA NA NA hsa-miR-181c-5p TAOK1 0.762784646696248 4.48373118147729e-10 -0.885269663736398 2.07708545034354e-08 mirMAP;miRNATAP -0.184827508522484 0.00932987001574384 NA NA NA hsa-miR-185-5p TAOK1 1.05056378692621 1.31174187880682e-22 -0.885269663736398 2.07708545034354e-08 mirMAP -0.240073930708533 0.00197771770457847 NA NA NA hsa-miR-18a-5p TAOK1 0.936704393213466 1.05064580570579e-10 -0.885269663736398 2.07708545034354e-08 MirTarget;miRNATAP -0.374804237649575 1.16717128080791e-10 NA NA NA hsa-miR-193a-3p TAOK1 0.849206638484406 3.68101781083335e-14 -0.885269663736398 2.07708545034354e-08 MirTarget;miRNATAP -0.397423210875142 1.39867604792322e-07 NA NA NA hsa-miR-193a-5p TAOK1 1.29777740059595 2.16815694068336e-39 -0.885269663736398 2.07708545034354e-08 TargetScan;miRNATAP -0.424552456447096 6.86213558854944e-08 NA NA NA hsa-miR-195-5p TAOK1 0.346502644882604 0.0092562828415903 -0.885269663736398 2.07708545034354e-08 MirTarget -0.258450232902536 0.00010006465250757 NA NA NA hsa-miR-196a-5p TAOK1 0.440858887700369 2.0077143292463e-05 -0.885269663736398 2.07708545034354e-08 miRNATAP -0.260641160299062 0.00229985175802091 NA NA NA hsa-miR-19a-3p TAOK1 0.722913586880779 2.76301458932381e-10 -0.885269663736398 2.07708545034354e-08 MirTarget;miRNATAP -0.314066638157774 3.04752791566313e-05 NA NA NA hsa-miR-19b-3p TAOK1 0.195940928879427 0.0300512922542325 -0.885269663736398 2.07708545034354e-08 MirTarget;miRNATAP -0.374003800301485 0.000153346075482186 NA NA NA hsa-miR-20a-5p TAOK1 0.702602695798242 4.06372887613329e-13 -0.885269663736398 2.07708545034354e-08 miRNATAP -0.355051259222971 6.07463563076455e-05 NA NA NA hsa-miR-21-3p TAOK1 1.78837590049697 1.41655409877312e-33 -0.885269663736398 2.07708545034354e-08 mirMAP -0.152537863974323 0.00484535963690137 NA NA NA hsa-miR-221-3p TAOK1 0.337895669520713 0.0136448974691037 -0.885269663736398 2.07708545034354e-08 miRNATAP -0.243946018557516 0.000160079668444225 NA NA NA hsa-miR-24-3p TAOK1 0.173813044685099 0.00565259443420961 -0.885269663736398 2.07708545034354e-08 MirTarget;miRNATAP -0.7640758800664 7.47430132629758e-08 NA NA NA hsa-miR-27a-3p TAOK1 0.558934437526245 1.44256383086177e-12 -0.885269663736398 2.07708545034354e-08 MirTarget -0.632115784149404 4.64938014394078e-09 NA NA NA hsa-miR-331-5p TAOK1 0.661186030542026 1.83628790002785e-08 -0.885269663736398 2.07708545034354e-08 mirMAP -0.229891220971413 0.00303188170612939 NA NA NA hsa-miR-339-5p TAOK1 0.322848334531193 0.0117281778821612 -0.885269663736398 2.07708545034354e-08 miRanda -0.235587218932357 0.000673820273069158 NA NA NA hsa-miR-340-5p TAOK1 1.14479851941741 2.91936881701444e-15 -0.885269663736398 2.07708545034354e-08 mirMAP -0.216129261478626 0.000220700967357424 NA NA NA hsa-miR-342-3p TAOK1 1.4124432570595 1.07208971556131e-28 -0.885269663736398 2.07708545034354e-08 miRanda -0.219734253511167 0.000597085994973847 NA NA NA hsa-miR-374a-3p TAOK1 1.13863935833993 2.79089304015401e-44 -0.885269663736398 2.07708545034354e-08 mirMAP -0.31813175387607 0.000865360506621408 NA NA NA hsa-miR-452-5p TAOK1 2.05325688842141 2.82238393643084e-40 -0.885269663736398 2.07708545034354e-08 MirTarget;miRNATAP -0.238362920742496 2.0474890700766e-06 NA NA NA hsa-miR-455-5p TAOK1 0.773674551205946 2.12957541541474e-09 -0.885269663736398 2.07708545034354e-08 MirTarget;miRNATAP -0.263307360944777 8.41614810970603e-05 NA NA NA hsa-miR-542-3p TAOK1 0.431147917094433 0.000254981247606435 -0.885269663736398 2.07708545034354e-08 miRanda -0.206807154923377 0.00595810081892307 NA NA NA hsa-miR-590-3p TAOK1 1.13702599385212 3.53435739887793e-22 -0.885269663736398 2.07708545034354e-08 miRanda;mirMAP -0.338315429443758 1.52733527342343e-06 NA NA NA hsa-miR-625-3p TAOK1 1.09679549288964 4.60800634006165e-20 -0.885269663736398 2.07708545034354e-08 mirMAP -0.245288107162038 0.000461144537115281 NA NA NA hsa-miR-625-5p TAOK1 0.153090549230629 0.330314026509869 -0.885269663736398 2.07708545034354e-08 MirTarget -0.186261893750505 0.00241524738556465 NA NA NA hsa-miR-93-5p TAOK1 1.37365940377595 2.37567548683245e-46 -0.885269663736398 2.07708545034354e-08 miRNATAP -0.363024090998496 5.22587391797302e-06 NA NA NA hsa-miR-106b-5p TAOK3 1.07509411417907 2.11739194181878e-36 -0.133327533932978 0.0165498197905255 MirTarget -0.157466964029026 7.28423774869867e-07 NA NA NA hsa-miR-361-5p TAOK3 0.0514169367202078 0.382929376393199 -0.133327533932978 0.0165498197905255 miRanda -0.165970071176773 0.00181448142922833 NA NA NA hsa-miR-139-5p TGFB1 -0.704802495091118 2.36904108453776e-06 1.54700279831576 2.78812914754058e-38 miRanda -0.229663915619583 2.28216718397939e-06 NA NA NA hsa-miR-744-5p TGFB1 -0.348985243196771 0.000187889982228835 1.54700279831576 2.78812914754058e-38 miRNAWalker2_validate;miRNATAP -0.399940904532963 3.45780106724256e-07 NA NA NA hsa-miR-107 TGFB2 0.140046250553248 0.0943611632552367 -0.469336292045935 0.000490251477006724 miRanda -0.559933447086514 2.03481629875917e-10 NA NA NA hsa-miR-130b-3p TGFB2 1.12788913578446 2.939369462276e-16 -0.469336292045935 0.000490251477006724 MirTarget;miRNATAP -0.156580751578969 0.00249097420975105 NA NA NA hsa-miR-142-5p TGFB2 1.88417391525707 1.2096808039882e-27 -0.469336292045935 0.000490251477006724 mirMAP -0.127254748923374 0.00130803131995633 NA NA NA hsa-miR-148a-3p TGFB2 0.343233211643815 0.00402279073598165 -0.469336292045935 0.000490251477006724 MirTarget;miRNATAP -0.246846036181106 7.29697456550998e-05 NA NA NA hsa-miR-148b-3p TGFB2 0.346011252093377 4.27203463315056e-06 -0.469336292045935 0.000490251477006724 MirTarget -0.360468526268224 0.000268375188449583 NA NA NA hsa-miR-193b-3p TGFB2 -0.273325765316079 0.104328826585392 -0.469336292045935 0.000490251477006724 MirTarget;miRNATAP -0.167973598355945 0.000145171044419197 NA NA NA hsa-miR-21-5p TGFB2 2.51462371613332 3.30620591950316e-66 -0.469336292045935 0.000490251477006724 miRNAWalker2_validate -0.131173211686422 0.00157690783662872 NA NA NA hsa-miR-29b-3p TGFB2 -0.228125979913806 0.0271621721891603 -0.469336292045935 0.000490251477006724 miRTarBase;MirTarget;miRNATAP -0.289170386615493 6.28377322853352e-05 NA NA NA hsa-miR-331-5p TGFB2 0.661186030542026 1.83628790002785e-08 -0.469336292045935 0.000490251477006724 miRNATAP -0.235323703080359 0.000288389309217486 NA NA NA hsa-miR-361-5p TGFB2 0.0514169367202078 0.382929376393199 -0.469336292045935 0.000490251477006724 miRNATAP -0.593277310323935 4.29304373395412e-06 NA NA NA hsa-miR-362-3p TGFB2 -0.753214251798232 3.0025661608035e-07 -0.469336292045935 0.000490251477006724 miRanda -0.151802483500752 0.00324883313613339 NA NA NA hsa-miR-374b-5p TGFB2 0.0804104684417872 0.365593963035077 -0.469336292045935 0.000490251477006724 mirMAP -0.302286565852539 0.000359174717531722 NA NA NA hsa-miR-454-3p TGFB2 0.68285296887698 1.17407812677787e-08 -0.469336292045935 0.000490251477006724 MirTarget;miRNATAP -0.186190333634062 0.00234395713860443 NA NA NA hsa-miR-590-3p TGFB2 1.13702599385212 3.53435739887793e-22 -0.469336292045935 0.000490251477006724 mirMAP -0.293207073092184 6.78797834982813e-07 NA NA NA hsa-miR-590-5p TGFB2 0.709763558412506 1.11883921359361e-11 -0.469336292045935 0.000490251477006724 miRanda;miRNATAP -0.256415439338522 0.000214547512438195 NA NA NA hsa-miR-616-5p TGFB2 0.913426384742148 3.78418389333709e-09 -0.469336292045935 0.000490251477006724 mirMAP -0.229064681057646 1.30218112799715e-06 NA NA NA hsa-miR-10a-5p TGFB3 -1.17164272592931 4.86621098042279e-24 0.891364650319448 3.84674758127802e-13 miRNAWalker2_validate -0.195492012609065 0.000520343467974493 NA NA NA hsa-miR-29b-3p TGFB3 -0.228125979913806 0.0271621721891603 0.891364650319448 3.84674758127802e-13 miRTarBase -0.21513711549002 0.00161883134704875 NA NA NA hsa-let-7d-5p TGFBR1 -0.0696879530236796 0.333110939877203 -0.139407625805428 0.0562036856015428 miRNAWalker2_validate;miRNATAP -0.161415640377896 0.0044449462418102 NA NA NA hsa-miR-101-3p TGFBR1 0.683973909682285 2.88573524246948e-15 -0.139407625805428 0.0562036856015428 miRNAWalker2_validate;miRNATAP -0.167025520155563 0.000175230182764941 NA NA NA hsa-miR-101-5p TGFBR1 -0.710089604234471 1.19159750684491e-09 -0.139407625805428 0.0562036856015428 mirMAP -0.104223311111533 0.00191673760816897 NA NA NA hsa-miR-126-5p TGFBR1 0.785607261431085 5.77058629454465e-13 -0.139407625805428 0.0562036856015428 mirMAP;miRNATAP -0.122965557743085 0.000540912677005276 NA NA NA hsa-miR-128-3p TGFBR1 0.475045893035043 2.6255647468e-06 -0.139407625805428 0.0562036856015428 miRNAWalker2_validate;miRTarBase -0.125843981727141 0.00136614048950141 NA NA NA hsa-miR-338-5p TGFBR1 0.628429807914222 1.27575140717947e-06 -0.139407625805428 0.0562036856015428 PITA;mirMAP;miRNATAP -0.117931437209265 0.000139480841045501 NA NA NA hsa-miR-361-5p TGFBR1 0.0514169367202078 0.382929376393199 -0.139407625805428 0.0562036856015428 miRanda;mirMAP;miRNATAP -0.260839310266332 0.000182561053501575 NA NA NA hsa-miR-374b-5p TGFBR1 0.0804104684417872 0.365593963035077 -0.139407625805428 0.0562036856015428 mirMAP -0.123179331066532 0.00702262805352141 NA NA NA hsa-miR-98-5p TGFBR1 0.0569715596189075 0.450575962846765 -0.139407625805428 0.0562036856015428 miRNAWalker2_validate -0.208111603369397 0.000107570382009014 NA NA NA hsa-miR-106b-5p TGFBR2 1.07509411417907 2.11739194181878e-36 -0.392800266100506 0.000685075520210389 miRNATAP -0.349038258399988 1.61435063203469e-07 NA NA NA hsa-miR-130b-3p TGFBR2 1.12788913578446 2.939369462276e-16 -0.392800266100506 0.000685075520210389 miRNAWalker2_validate;miRNATAP -0.185326136530808 2.70386843045027e-05 25024357 Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC lung squamous cell cancer hsa-miR-18a-5p TGFBR2 0.936704393213466 1.05064580570579e-10 -0.392800266100506 0.000685075520210389 miRNAWalker2_validate -0.16961355943703 7.30860641372394e-05 NA NA NA hsa-miR-21-5p TGFBR2 2.51462371613332 3.30620591950316e-66 -0.392800266100506 0.000685075520210389 miRNAWalker2_validate;miRTarBase;miRNATAP -0.16629341994918 2.46933773961822e-06 24037531 Androgen receptor and microRNA 21 axis downregulates transforming growth factor beta receptor II TGFBR2 expression in prostate cancer; Our results revealed that miR-21 suppresses TGFBR2 levels by binding to its 3'-UTR and AR signaling further potentiates this effect in both untransformed and transformed human prostate epithelial cells as well as in human prostate cancers; Manipulation of androgen signaling or the expression levels of AR or miR-21 negatively altered TGFBR2 expression in untransformed and transformed human prostate epithelial cells human prostate cancer xenografts and mouse prostate glands; Together these results suggest that the AR and miR-21 axis exerts its oncogenic effects in prostate tumors by downregulating TGFBR2 hence inhibiting the tumor-suppressive activity of TGFβ pathway prostate cancer hsa-miR-590-3p TGFBR2 1.13702599385212 3.53435739887793e-22 -0.392800266100506 0.000685075520210389 miRanda -0.227093418005756 7.99092099509756e-06 NA NA NA hsa-miR-590-5p TGFBR2 0.709763558412506 1.11883921359361e-11 -0.392800266100506 0.000685075520210389 miRNAWalker2_validate;miRTarBase;PITA;miRanda;miRNATAP -0.231380291088817 9.82241155278765e-05 NA NA NA hsa-miR-93-5p TGFBR2 1.37365940377595 2.37567548683245e-46 -0.392800266100506 0.000685075520210389 miRNAWalker2_validate;miRNATAP -0.168687997812164 0.00362979330118336 NA NA NA hsa-let-7e-5p TNFRSF1A -0.727009689927955 1.30690859412163e-11 1.05144580156796 6.15984515961538e-37 miRNAWalker2_validate -0.243475340326271 9.72227511621154e-08 NA NA NA hsa-miR-29a-3p TNFRSF1A -0.431613225927952 4.10166815070288e-08 1.05144580156796 6.15984515961538e-37 MirTarget;miRNATAP -0.221660330239268 0.000574068692698324 NA NA NA hsa-miR-29c-3p TNFRSF1A -0.238671318446745 0.0141475322347596 1.05144580156796 6.15984515961538e-37 MirTarget;miRNATAP -0.166214002162491 0.00165168684467284 NA NA NA hsa-miR-10b-5p TP53 -0.89971464210447 1.18190532299934e-20 0.517978122391951 5.84571553070906e-18 miRNAWalker2_validate;miRTarBase -0.178289673371273 1.01311520211069e-07 NA NA NA hsa-miR-125a-5p TP53 -0.561874059994802 7.3931856356891e-13 0.517978122391951 5.84571553070906e-18 miRNAWalker2_validate;miRTarBase;miRanda -0.169369198879199 8.24720080675124e-05 26389681;21777146;23079745 Mechanistically inactivation of miR-125a during cervical carcinogenesis was caused by HPV suppression of p53 expression;In addition wild-type p53 mRNA and protein expression was increased by hsa-miR-125a-5p overexpression; Moreover blocking wild-type p53 attenuated the effect of hsa-miR-125a-5p on apoptosis; In loss-of-function experiments wild-type p53 mRNA and protein expression was decreased by blocking hsa-miR-125a-5p; The effect of hsa-miR-125a-5p inhibitor on apoptosis was also weakened by blocking wild-type p53;Furthermore treatment of HCC cells with 5-aza-2'-deoxycytidine or ectopic expression of wildtype but not mutated p53 restored miR-125a-5p and miR-125b expression and inhibited tumor cell growth suggesting their regulation by promoter methylation and p53 activity tumorigenesis;; cervical and endocervical cancer;lung cancer;liver cancer hsa-miR-125b-5p TP53 -0.825456421494266 2.13029877878434e-15 0.517978122391951 5.84571553070906e-18 miRNAWalker2_validate;miRTarBase -0.164499575889924 1.96885947372224e-07 24846940;26335100;24137477;26686386;24402874;21399871;23585871;24762088;24169356;23079745 The results revealed that hsa-miR-125b may regulate multiple biological processes and signal transduction pathways and drug-resistant occurrence is associated with cell proliferation cell apoptosis cell cycle and signaling pathways including MAPK Wnt and p53;The carboxy terminal domain of connexin 43 CT Cx43 modulates the expression of p53 by altering miR 125b expression in low grade human breast cancers; In addition CT-Cx43 was exogenously expressed in the breast cancer-derived cell line MCF-7 and its effect on the expression of miR-125b and its downstream target p53 were evaluated as well as its effect on cellular proliferation and death using MTT and LDH assays respectively; Interestingly we found that miR-125b a negative regulator of p53 exhibited an inverse expression relationship with CT-Cx43 in the breast cancer samples tested;TP53 and hsa-miR-125b were observed to form a self-adaptation association;In this study we have investigated the delivery and transfection of wild-type wt- p53 and microRNA-125b miR-125b expressing plasmid DNA in SK-LU-1 human lung adenocarcinoma cells as well as in KrasG12D/p53fl/fl KP genetically engineered mouse model of lung cancer;miR-34a is directly regulated by p53 and acts as tumor suppressor while miR-125b plays a significant role in immune response and apoptosis;In vitro assays revealed that overexpression of miR-125b repressed the endogenous level of p53 protein in human colorectal cancer cells;In this study we further extend our studies by showing that miR-125b represses the protein product of the ink4a/ARF locus p14ARF in two prostate cancer cell lines LNCaP wild type-p53 and 22Rv1 both wild type and mutant p53 as well as in the PC-346C prostate cancer xenograft model that lentivirally overexpressed miR-125b;A stable overexpression of miR-125b in human melanoma cell line Mel-Juso resulted in a G0/G1 cell cycle block and emergence of large cells expressing senescence markers: senescence-associated beta-galactosidase p21 p27 and p53;MiR 125b acts as an oncogene in glioblastoma cells and inhibits cell apoptosis through p53 and p38MAPK independent pathways; Further studies reveal that p53 is regulated by miR-125b; However downregulation of the endogenous miR-125b also results in p53-independent apoptotic pathway leading to apoptosis in p53 mutated U251 cells and p53 knockdown U87 cells;Furthermore treatment of HCC cells with 5-aza-2'-deoxycytidine or ectopic expression of wildtype but not mutated p53 restored miR-125a-5p and miR-125b expression and inhibited tumor cell growth suggesting their regulation by promoter methylation and p53 activity; To show the clinical significance of these findings mutations in the DNA binding domain of p53 and promoter methylation of miR-125b were investigated; Four out of nine patients with induced SIRT7 carried mutations in the p53 gene and one patient showed hypermethylation of the miR-125b promoter region ;;;;immune resistance;;;;; gastric cancer;breast cancer;pancreatic cancer;lung cancer;cervical and endocervical cancer;colorectal cancer;prostate cancer;melanoma;glioblastoma;liver cancer hsa-miR-30d-5p TP53 -0.202727675788184 0.00659067084745794 0.517978122391951 5.84571553070906e-18 miRNAWalker2_validate -0.234010250909245 4.72794888119438e-07 NA NA NA hsa-miR-214-5p TRAF2 -1.44418790803397 1.50873538772684e-16 1.00837223645711 2.28827353275856e-27 MirTarget -0.125451680485327 3.28324341648322e-05 NA NA NA hsa-miR-532-3p TRAF2 -1.759223962964 7.9077916669414e-40 1.00837223645711 2.28827353275856e-27 MirTarget -0.198817577762592 4.73764851958879e-08 NA NA NA hsa-miR-15a-5p TRAF6 1.42663930007845 1.36006952074963e-57 -0.154756221076495 0.0251134821615502 MirTarget -0.131672628775391 0.000220807225625882 NA NA NA hsa-miR-15b-5p TRAF6 0.773001494057531 1.71784656078957e-16 -0.154756221076495 0.0251134821615502 MirTarget -0.202598937613954 1.20911977647419e-07 NA NA NA hsa-miR-16-5p TRAF6 0.934012514027655 4.85417898318515e-24 -0.154756221076495 0.0251134821615502 MirTarget -0.114963949953757 0.00280625554679509 NA NA NA