miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-148a-3p A4GNT -0.748702855596996 3.93313343865641e-07 -1.23788904255124 0.00041788399420954 MirTarget -0.727930454392835 1.19337356882915e-10 NA NA NA hsa-miR-27b-3p AAGAB -0.823491817819754 9.20935302746823e-14 0.452586391901909 1.6681499731678e-13 MirTarget -0.1257366499343 2.69803797606813e-06 NA NA NA hsa-miR-20a-5p ABHD2 0.854326758727003 5.04256669663285e-07 -1.20462139360653 3.09717296882448e-15 miRNATAP -0.280755866928053 1.59918873748929e-10 NA NA NA hsa-miR-20a-5p ABHD5 0.854326758727003 5.04256669663285e-07 -0.597165516206204 1.07129426217362e-09 MirTarget -0.124155074971842 9.40698978083883e-06 NA NA NA hsa-miR-20a-5p ACER3 0.854326758727003 5.04256669663285e-07 0.019931089805842 0.84603738107892 mirMAP -0.123555370663773 1.73924053330843e-05 NA NA NA hsa-miR-148a-3p ACHE -0.748702855596996 3.93313343865641e-07 0.0664775463470139 0.84521711408755 miRNATAP -0.644498628240824 3.7505390632337e-09 NA NA NA hsa-miR-20a-5p ACOX1 0.854326758727003 5.04256669663285e-07 -1.15808823365487 5.04381483675569e-16 mirMAP -0.146498998226335 0.000460144478820645 NA NA NA hsa-miR-192-5p ACPP -0.50188499512787 0.00344713341196035 -0.469596543578405 0.142691148120666 MirTarget -0.440640771483494 9.58060705830871e-07 NA NA NA hsa-miR-148a-3p ACSL4 -0.748702855596996 3.93313343865641e-07 2.07128895001209 1.06074462060898e-08 miRNATAP -0.646374144431349 5.43959417232703e-08 NA NA NA hsa-miR-20a-5p ACSL6 0.854326758727003 5.04256669663285e-07 0.391527588368073 0.264580316303862 mirMAP -0.211210152354206 0.033875040869321 NA NA NA hsa-miR-20a-5p ACTR3C 0.854326758727003 5.04256669663285e-07 -0.985194095129949 4.59271183901734e-09 mirMAP -0.213829247859042 8.91705073520534e-06 NA NA NA hsa-miR-148a-3p ACVR1 -0.748702855596996 3.93313343865641e-07 -0.436041316598948 1.42037811134341e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.127757812095218 0.000102607735840908 NA NA NA hsa-miR-92a-1-5p ACY1 0.389443191151075 0.0644925359204601 -1.03779253032075 2.08076971716154e-10 MirTarget -0.150705845314542 9.12802425574096e-05 NA NA NA hsa-miR-148a-3p ADAM10 -0.748702855596996 3.93313343865641e-07 -0.00403457779534389 0.978295883029657 MirTarget -0.110219431820108 0.02275270707882 NA NA NA hsa-miR-148a-3p ADAM19 -0.748702855596996 3.93313343865641e-07 -0.32160702928448 0.0232139582513919 mirMAP -0.325649695504387 5.14611973715324e-13 NA NA NA hsa-miR-148a-3p ADAM22 -0.748702855596996 3.93313343865641e-07 1.16776109376783 0.000384818007613429 MirTarget;miRNATAP -0.570717351275375 9.08076638454519e-08 NA NA NA hsa-miR-148a-3p ADAM23 -0.748702855596996 3.93313343865641e-07 1.53172738337562 0.000126500167051167 MirTarget -0.471790043846003 0.000320728545434591 NA NA NA hsa-miR-20a-5p ADAM9 0.854326758727003 5.04256669663285e-07 0.469254461950823 0.0058074096052033 miRNATAP -0.235866281897525 8.13909538840547e-07 NA NA NA hsa-miR-27b-3p ADAMTS10 -0.823491817819754 9.20935302746823e-14 0.72666035489938 0.0018715247175307 MirTarget;miRNATAP -0.258537966322947 0.0105853013951589 NA NA NA hsa-miR-148a-3p ADAMTS15 -0.748702855596996 3.93313343865641e-07 -0.880416409258241 0.00205636793456789 MirTarget;miRNATAP -0.407109521853394 1.22320303172348e-05 NA NA NA hsa-miR-148a-3p ADAMTS18 -0.748702855596996 3.93313343865641e-07 1.43554458022524 5.55511372449862e-06 miRNATAP -0.208100007448669 0.0466744182094337 NA NA NA hsa-miR-148a-3p ADAMTS5 -0.748702855596996 3.93313343865641e-07 -0.158955986983549 0.364991157590809 miRNATAP -0.306850769456875 5.57468547782841e-08 NA NA NA hsa-miR-20a-5p ADAMTS5 0.854326758727003 5.04256669663285e-07 -0.158955986983549 0.364991157590809 miRNATAP -0.16016847364099 0.00122472300616835 NA NA NA hsa-miR-27b-3p ADAMTS6 -0.823491817819754 9.20935302746823e-14 0.701299206204912 0.00474632625270224 miRNATAP -0.259661369852688 0.0156682886243402 NA NA NA hsa-miR-192-5p ADARB1 -0.50188499512787 0.00344713341196035 -0.132229476875825 0.222084732765285 mirMAP -0.127398503530106 2.81068891888585e-05 NA NA NA hsa-miR-20a-5p ADARB1 0.854326758727003 5.04256669663285e-07 -0.132229476875825 0.222084732765285 MirTarget -0.112052206383323 0.000235724844781083 NA NA NA hsa-miR-27b-3p ADCY3 -0.823491817819754 9.20935302746823e-14 0.145108134687769 0.339294243758741 miRNATAP -0.164435507463425 0.0118469252612308 NA NA NA hsa-miR-27b-3p ADCY6 -0.823491817819754 9.20935302746823e-14 1.2491833959113 3.10957713063109e-35 MirTarget;miRNATAP -0.211478858423228 6.61477941867918e-06 NA NA NA hsa-miR-148a-3p ADM2 -0.748702855596996 3.93313343865641e-07 1.7229047600607 3.16835442282685e-11 mirMAP -0.426317474351994 7.21843489038708e-07 NA NA NA hsa-miR-148a-3p ADPRH -0.748702855596996 3.93313343865641e-07 -0.127900064307657 0.267398619612325 MirTarget -0.246854409712485 1.81775560789359e-11 NA NA NA hsa-miR-20a-5p ADRA2A 0.854326758727003 5.04256669663285e-07 -0.755954292905646 0.0255837717858082 miRNATAP -0.403357526197757 2.40618643447532e-05 NA NA NA hsa-miR-192-5p AFAP1 -0.50188499512787 0.00344713341196035 0.333594871057281 0.0594854227669168 mirMAP -0.48561537237124 1.2156716957883e-24 NA NA NA hsa-miR-192-5p AFAP1L1 -0.50188499512787 0.00344713341196035 0.539121502171087 1.03832634002658e-05 miRNAWalker2_validate -0.178239775876725 2.48832203322505e-07 NA NA NA hsa-miR-192-5p AFF2 -0.50188499512787 0.00344713341196035 1.39588537883969 0.000457287577801629 mirMAP -0.511809488487438 5.61390476636637e-06 NA NA NA hsa-miR-20a-5p AFF4 0.854326758727003 5.04256669663285e-07 -0.640374726233926 1.97427244265237e-11 miRNATAP -0.128546625882855 2.71936066374717e-06 NA NA NA hsa-miR-27b-3p AGRN -0.823491817819754 9.20935302746823e-14 0.715007721538266 3.92826741843964e-07 MirTarget;miRNATAP -0.234750701169806 0.000126157039693138 NA NA NA hsa-miR-148a-3p AHDC1 -0.748702855596996 3.93313343865641e-07 -0.233452674379399 0.0262629700720901 miRNATAP -0.118432059847956 0.000531083692723168 NA NA NA hsa-miR-20a-5p AHRR 0.854326758727003 5.04256669663285e-07 0.374731818843264 0.0937279302372394 MirTarget -0.128518879972634 0.0428800248545702 NA NA NA hsa-miR-20a-5p AKAP13 0.854326758727003 5.04256669663285e-07 -0.316044656326872 0.00142457099117573 MirTarget;mirMAP;miRNATAP -0.12287674826508 1.06980359153594e-05 NA NA NA hsa-miR-92a-1-5p AKAP6 0.389443191151075 0.0644925359204601 -0.968677768825482 1.23169099553274e-07 MirTarget -0.284322583421952 1.50270922382404e-11 NA NA NA hsa-miR-192-5p AKAP7 -0.50188499512787 0.00344713341196035 -0.934162506524967 8.3523005694695e-09 miRNAWalker2_validate -0.116255612050066 0.01300691891511 NA NA NA hsa-miR-20a-5p AKT3 0.854326758727003 5.04256669663285e-07 -0.658799312069129 0.000471762262250455 miRNATAP -0.294574079686222 2.60181650003526e-08 NA NA NA hsa-miR-20a-5p AKTIP 0.854326758727003 5.04256669663285e-07 -0.372267282592632 0.000538928886172555 MirTarget;miRNATAP -0.250968335671779 1.42167261059228e-17 NA NA NA hsa-miR-20a-5p ALDH1A3 0.854326758727003 5.04256669663285e-07 -2.13218776108874 9.32543225662656e-10 mirMAP -0.584921054666842 3.66358641228591e-09 NA NA NA hsa-miR-20a-5p ALDH3A2 0.854326758727003 5.04256669663285e-07 -0.549782198205341 0.000215333966024332 mirMAP -0.104054385711556 0.0140413640546679 NA NA NA hsa-miR-148a-3p AMZ1 -0.748702855596996 3.93313343865641e-07 -1.27523518848137 0.00014004218753246 mirMAP -0.439309250759227 6.17486486218864e-05 NA NA NA hsa-miR-148a-3p ANK2 -0.748702855596996 3.93313343865641e-07 -0.936784357118896 8.39839404737194e-05 MirTarget;miRNATAP -0.442851290420514 9.87487353462611e-09 NA NA NA hsa-miR-20a-5p ANKIB1 0.854326758727003 5.04256669663285e-07 0.067345906471652 0.505512136479813 miRNATAP -0.113921563191973 5.98025631506191e-05 NA NA NA hsa-miR-148a-3p ANKRD27 -0.748702855596996 3.93313343865641e-07 0.900670804616695 4.42329061698872e-15 mirMAP -0.177436391740684 3.94392699827362e-06 NA NA NA hsa-miR-27b-3p ANKRD27 -0.823491817819754 9.20935302746823e-14 0.900670804616695 4.42329061698872e-15 MirTarget -0.291289051724581 7.18671140773929e-09 NA NA NA hsa-miR-20a-5p ANKRD29 0.854326758727003 5.04256669663285e-07 1.13442887011441 3.88269238474571e-05 MirTarget -0.339619682018072 1.42784915371571e-05 NA NA NA hsa-miR-20a-5p ANKRD50 0.854326758727003 5.04256669663285e-07 -0.252776516079819 0.0443267488846649 MirTarget;miRNATAP -0.204431209041044 5.30055881780065e-09 NA NA NA hsa-miR-148a-3p ANKRD52 -0.748702855596996 3.93313343865641e-07 1.45719998646575 1.747377108051e-36 mirMAP;miRNATAP -0.254983576295231 2.94153541356069e-10 NA NA NA hsa-miR-192-5p ANKRD52 -0.50188499512787 0.00344713341196035 1.45719998646575 1.747377108051e-36 mirMAP -0.161920111656283 5.09500737908452e-06 NA NA NA hsa-miR-27b-3p ANKRD52 -0.823491817819754 9.20935302746823e-14 1.45719998646575 1.747377108051e-36 miRNAWalker2_validate -0.284938653452139 1.13235136495351e-07 NA NA NA hsa-miR-148a-3p ANKS6 -0.748702855596996 3.93313343865641e-07 0.759243866236994 0.0152104928778901 mirMAP -0.627092112569914 4.43139828118081e-10 NA NA NA hsa-miR-192-5p ANLN -0.50188499512787 0.00344713341196035 3.88656909930585 1.21152402703192e-46 miRNAWalker2_validate -0.203999078919904 0.0182411785223461 NA NA NA hsa-miR-20a-5p ANO6 0.854326758727003 5.04256669663285e-07 -0.291765828721766 0.00463644529629324 MirTarget -0.106904979606777 0.00023908900938888 NA NA NA hsa-miR-148a-3p ANXA4 -0.748702855596996 3.93313343865641e-07 -0.204045790335896 0.167003285162076 MirTarget -0.35947112824918 1.42075019192064e-14 NA NA NA hsa-miR-192-5p AP1S2 -0.50188499512787 0.00344713341196035 -0.395973387919881 0.000493972914950454 miRNAWalker2_validate -0.327460865551955 3.57573083470452e-27 NA NA NA hsa-miR-192-5p AP3M2 -0.50188499512787 0.00344713341196035 0.873042146815553 2.35328106646397e-15 miRNAWalker2_validate -0.278654218086517 2.0527304232252e-19 NA NA NA hsa-miR-20a-5p APBB2 0.854326758727003 5.04256669663285e-07 -0.236685537022579 0.0308537760053906 MirTarget;miRNATAP -0.191936597293415 2.83430270311816e-10 NA NA NA hsa-miR-106b-5p APC 0.648901865047099 8.24870862047885e-09 -0.178106776451097 0.0679159506996304 miRNAWalker2_validate;miRTarBase -0.152406181389829 0.000242059519728295 23087084 miR 106b downregulates adenomatous polyposis coli and promotes cell proliferation in human hepatocellular carcinoma; Moreover we demonstrated that miR-106b downregulates APC expression by directly targeting the 3'-untranslated region of APC messenger RNA; Taken together our results suggest that miR-106b plays an important role in promoting the proliferation of human hepatoma cells and presents a novel mechanism of micro RNA-mediated direct suppression of APC expression in cancer cells liver cancer hsa-miR-21-5p APC 1.51084295924322 1.54551622173259e-34 -0.178106776451097 0.0679159506996304 miRNAWalker2_validate -0.170963654395431 1.15664392926358e-06 23773491;24832083 The prognostic significance of APC gene mutation and miR 21 expression in advanced stage colorectal cancer; The aim of this study was to analyse the association of APC gene mutation and miR-21 expression with clinical outcome in CRC patients; APC gene mutation and expression of APC and miR-21 were analysed by direct DNA sequencing and real-time reverse transcription polymerase chain reaction; APC gene expression was low in CRC and negatively correlated with miR-21 expression and gene mutation; In Taiwan downregulation of the APC gene in CRC correlated with gene mutation and miR-21 upregulation; APC mutation and miR-21 expression could be used to predict the clinical outcome of CRC especially in patients with advanced disease;MicroRNA 21 promotes tumour malignancy via increased nuclear translocation of β catenin and predicts poor outcome in APC mutated but not in APC wild type colorectal cancer; However in our preliminary data the prognostic value of miR-21 levels was observed only in adenomatous polyposis coli APC-mutated tumours not in APC-wild-type tumours; We enrolled 165 colorectal tumour to determine APC mutation miR-21 levels and nuclear β-catenin expression by direct sequencing real-time PCR and immunohistochemistry staging; colorectal cancer;colorectal cancer hsa-miR-20a-5p APCDD1 0.854326758727003 5.04256669663285e-07 -1.30282968453375 0.000425498278202489 MirTarget -0.340479221311948 0.00121126699273569 NA NA NA hsa-miR-20a-5p AR 0.854326758727003 5.04256669663285e-07 -2.65514434874701 6.79656050811819e-11 mirMAP -0.725850826781021 3.75624697520003e-10 NA NA NA hsa-miR-148a-3p ARAP2 -0.748702855596996 3.93313343865641e-07 -1.13466869294013 1.21001797842144e-11 MirTarget -0.263514528901823 2.11834622572004e-06 NA NA NA hsa-miR-20a-5p ARAP2 0.854326758727003 5.04256669663285e-07 -1.13466869294013 1.21001797842144e-11 MirTarget -0.20944314137112 1.44427566523601e-05 NA NA NA hsa-miR-192-5p ARF3 -0.50188499512787 0.00344713341196035 0.177253463256622 0.00421607027312191 mirMAP -0.138664075567025 1.8621761611359e-16 NA NA NA hsa-miR-27b-3p ARF3 -0.823491817819754 9.20935302746823e-14 0.177253463256622 0.00421607027312191 MirTarget -0.149025281031523 1.19134496034957e-08 NA NA NA hsa-miR-27b-3p ARHGAP12 -0.823491817819754 9.20935302746823e-14 0.0370899211582838 0.722482993769925 miRNATAP -0.108189350969651 0.0158461411311389 NA NA NA hsa-miR-20a-5p ARHGAP23 0.854326758727003 5.04256669663285e-07 -0.144534678234969 0.329845622280863 mirMAP -0.179798589478187 1.58782570453225e-05 NA NA NA hsa-miR-20a-5p ARHGAP24 0.854326758727003 5.04256669663285e-07 -0.989759863701917 1.90104401611984e-08 MirTarget -0.239221669437707 1.94621639898914e-06 NA NA NA hsa-miR-103a-3p ARHGAP5 0.765568928457606 3.05497476509383e-12 -0.390501975399923 8.01729872271933e-05 MirTarget -0.190378797120845 9.62393438802819e-06 NA NA NA hsa-miR-155-5p ARHGAP5 0.0108524225071784 0.95651331033505 -0.390501975399923 8.01729872271933e-05 mirMAP -0.106689067532435 1.07117354005012e-05 NA NA NA hsa-miR-15a-5p ARHGAP5 0.349521211668244 0.000770735998804736 -0.390501975399923 8.01729872271933e-05 MirTarget;miRNATAP -0.140114967228855 0.00276448285918912 NA NA NA hsa-miR-16-1-3p ARHGAP5 0.392360028038559 0.00112481918108198 -0.390501975399923 8.01729872271933e-05 MirTarget -0.10655854170515 0.00823158833704956 NA NA NA hsa-miR-17-5p ARHGAP5 0.698861147045461 2.43854106455398e-05 -0.390501975399923 8.01729872271933e-05 miRNAWalker2_validate -0.168233712468027 4.06938935137717e-09 NA NA NA hsa-miR-181a-5p ARHGAP5 0.250113435902954 0.0551933249319293 -0.390501975399923 8.01729872271933e-05 mirMAP -0.178285338979484 1.42745874554536e-06 NA NA NA hsa-miR-181b-5p ARHGAP5 0.488256489401108 0.00105321129419701 -0.390501975399923 8.01729872271933e-05 mirMAP -0.156486821983914 1.13906378427161e-06 NA NA NA hsa-miR-18a-5p ARHGAP5 0.918028187958706 1.90229510425322e-05 -0.390501975399923 8.01729872271933e-05 MirTarget -0.139657415536736 1.92972267421708e-10 NA NA NA hsa-miR-19a-3p ARHGAP5 1.01712596153672 2.57753201450625e-07 -0.390501975399923 8.01729872271933e-05 miRNATAP -0.102176278799659 2.18507337800794e-05 NA NA NA hsa-miR-19b-3p ARHGAP5 0.601279551368824 0.00016685097085251 -0.390501975399923 8.01729872271933e-05 miRNATAP -0.126249258755046 2.62351845075989e-05 NA NA NA hsa-miR-421 ARHGAP5 0.941856334694081 6.12167297054077e-08 -0.390501975399923 8.01729872271933e-05 PITA;miRanda;mirMAP;miRNATAP -0.100369042715833 0.000260906838220345 NA NA NA hsa-miR-500a-5p ARHGAP5 0.797906382969156 9.15958171084226e-08 -0.390501975399923 8.01729872271933e-05 mirMAP -0.130200028078366 4.44416835178627e-05 NA NA NA hsa-miR-501-5p ARHGAP5 1.15231083477882 2.98906150004088e-10 -0.390501975399923 8.01729872271933e-05 PITA;mirMAP -0.135613237661836 1.27605396391392e-07 NA NA NA hsa-miR-590-5p ARHGAP5 -0.103355559980404 0.310027295317092 -0.390501975399923 8.01729872271933e-05 miRanda -0.125900328591526 0.00896894861120512 NA NA NA hsa-miR-192-5p ARHGEF10 -0.50188499512787 0.00344713341196035 0.0457284063732661 0.788871825212443 miRNAWalker2_validate -0.424443709514871 3.75969294346877e-20 NA NA NA hsa-miR-148a-3p ARHGEF17 -0.748702855596996 3.93313343865641e-07 0.063804626387558 0.699136901516712 miRNATAP -0.457419364506958 7.79553515305781e-19 NA NA NA hsa-miR-27b-3p ARHGEF37 -0.823491817819754 9.20935302746823e-14 1.10732664939969 7.07735549130854e-06 MirTarget -0.257123731542649 0.0167140143678827 NA NA NA hsa-miR-192-5p ARID5B -0.50188499512787 0.00344713341196035 -0.51790455974164 0.000116493206015505 mirMAP -0.160948774805613 2.38284113447348e-05 NA NA NA hsa-miR-20a-5p ARL10 0.854326758727003 5.04256669663285e-07 -0.416388129451091 0.0155583304348665 mirMAP -0.101112777931085 0.0387491076874815 NA NA NA hsa-miR-20a-5p ARL13B 0.854326758727003 5.04256669663285e-07 -0.316629429743313 0.0119647415921429 MirTarget -0.114333354634642 0.00134104046938039 NA NA NA hsa-miR-192-5p ARL4C -0.50188499512787 0.00344713341196035 -0.828784149026158 1.2682062092253e-05 miRNAWalker2_validate -0.445961050684204 1.44230749334181e-17 NA NA NA hsa-miR-20a-5p ARL4C 0.854326758727003 5.04256669663285e-07 -0.828784149026158 1.2682062092253e-05 MirTarget;miRNATAP -0.110688777952846 0.0418836797572384 NA NA NA hsa-miR-192-5p ARNTL2 -0.50188499512787 0.00344713341196035 0.0223855120215825 0.941117167316514 miRNAWalker2_validate -0.265231940122221 0.00196654272615323 NA NA NA hsa-miR-20a-5p ARSD 0.854326758727003 5.04256669663285e-07 -1.15703048361889 2.52321723033514e-14 mirMAP -0.325380843692538 4.50390878399019e-14 NA NA NA hsa-miR-20a-5p ASPA 0.854326758727003 5.04256669663285e-07 -2.87708424623409 2.78732403857851e-24 mirMAP -0.228916734793071 0.007122528796685 NA NA NA hsa-miR-192-5p ASPH -0.50188499512787 0.00344713341196035 0.471205919674361 0.00524665556215563 miRNAWalker2_validate -0.106928181337855 0.0260299670438736 NA NA NA hsa-miR-20a-5p ATE1 0.854326758727003 5.04256669663285e-07 -0.60221529485003 0.000898690867899849 MirTarget -0.113270446654085 0.0284492547112625 NA NA NA hsa-miR-148a-3p ATG4D -0.748702855596996 3.93313343865641e-07 0.238017440609291 0.0358760810215454 MirTarget -0.177564676097827 1.28064680165471e-06 NA NA NA hsa-miR-20a-5p ATL3 0.854326758727003 5.04256669663285e-07 0.128948695025344 0.252547833929954 miRNAWalker2_validate;MirTarget;miRNATAP -0.195920409876506 3.53974812154164e-10 NA NA NA hsa-miR-192-5p ATP10D -0.50188499512787 0.00344713341196035 -0.428042218506426 0.00646320508391909 miRNAWalker2_validate -0.125699577457152 0.00485942347009186 NA NA NA hsa-miR-148a-3p ATP11A -0.748702855596996 3.93313343865641e-07 0.189226775577938 0.159981440120013 MirTarget -0.168910484576989 0.000112028647058078 NA NA NA hsa-miR-20a-5p ATP1A2 0.854326758727003 5.04256669663285e-07 0.511083548392086 0.111207698032313 MirTarget;miRNATAP -0.320066988550342 0.000414612772175907 NA NA NA hsa-miR-148a-3p ATP2B4 -0.748702855596996 3.93313343865641e-07 0.270147249141007 0.0673602510700001 MirTarget;miRNATAP -0.111342871164415 0.0211096551467596 NA NA NA hsa-miR-148a-3p ATP7A -0.748702855596996 3.93313343865641e-07 0.251321858484382 0.0188455783467549 MirTarget;miRNATAP -0.117619391345964 0.000738334866649139 NA NA NA hsa-miR-192-5p ATP8B4 -0.50188499512787 0.00344713341196035 -1.1029205581874 1.42707460187988e-12 MirTarget -0.111997394935168 0.0136511900662527 NA NA NA hsa-miR-20a-5p ATRX 0.854326758727003 5.04256669663285e-07 -0.0677373088337614 0.487587480385071 mirMAP -0.125292083620034 4.43330227389919e-06 NA NA NA hsa-miR-20a-5p ATXN1L 0.854326758727003 5.04256669663285e-07 0.0891645419015585 0.389564952054527 miRNATAP -0.132523129952088 4.91843785893201e-06 NA NA NA hsa-miR-27b-3p ATXN2L -0.823491817819754 9.20935302746823e-14 0.611974248116638 1.12366931914732e-16 miRNATAP -0.181052371662931 2.32472693550681e-08 NA NA NA hsa-miR-148a-3p AURKB -0.748702855596996 3.93313343865641e-07 3.49342722879335 6.3137526890155e-40 miRNAWalker2_validate -0.529634555771283 1.73415568417495e-08 NA NA NA hsa-let-7b-3p AXIN2 -1.21979213547786 5.84575581584603e-17 0.113841868770703 0.752977397700815 miRNATAP -0.270257334726793 0.0204955473660487 NA NA NA hsa-let-7g-3p AXIN2 -1.14091000722297 8.32736018188759e-19 0.113841868770703 0.752977397700815 MirTarget -0.333163518873582 0.0112609172880632 NA NA NA hsa-miR-15b-5p AXIN2 0.230566941413564 0.0824765001857479 0.113841868770703 0.752977397700815 miRTarBase;MirTarget;miRNATAP -0.445214007102522 0.000810754926318775 NA NA NA hsa-miR-16-2-3p AXIN2 -0.0336420826463706 0.805158952566973 0.113841868770703 0.752977397700815 mirMAP -0.637896819806337 6.99346379238779e-07 NA NA NA hsa-miR-16-5p AXIN2 -0.398577235179603 0.000101598495180191 0.113841868770703 0.752977397700815 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.492511513287746 0.00421170477125135 NA NA NA hsa-miR-195-3p AXIN2 -1.09375690196245 4.70092324819807e-09 0.113841868770703 0.752977397700815 mirMAP -0.313128484413814 0.000828518151480385 NA NA NA hsa-miR-195-5p AXIN2 -1.85907534356434 1.47434041676402e-22 0.113841868770703 0.752977397700815 MirTarget;miRNATAP -0.245874041969712 0.00506110437798971 NA NA NA hsa-miR-26b-3p AXIN2 -1.25503731613309 4.45390890119649e-27 0.113841868770703 0.752977397700815 MirTarget -0.591476065389494 2.94301063245798e-05 NA NA NA hsa-miR-326 AXIN2 -1.881935132554 1.68087316863775e-21 0.113841868770703 0.752977397700815 miRanda -0.362520003418692 1.98590653589597e-05 NA NA NA hsa-miR-338-5p AXIN2 -0.221898432884726 0.252390988727086 0.113841868770703 0.752977397700815 miRNATAP -0.342154956032422 0.000172654921949776 NA NA NA hsa-miR-424-5p AXIN2 -2.62653257498508 2.38997974737991e-50 0.113841868770703 0.752977397700815 MirTarget;miRNATAP -0.191832991796132 0.0301808709524209 NA NA NA hsa-miR-497-5p AXIN2 -1.41371173021948 7.09278946477743e-17 0.113841868770703 0.752977397700815 MirTarget;miRNATAP -0.294042209891213 0.00328690230713159 NA NA NA hsa-miR-616-3p AXIN2 -0.699516741506971 1.82225985970292e-05 0.113841868770703 0.752977397700815 MirTarget -0.422833368838949 7.60561180413777e-05 NA NA NA hsa-miR-192-5p B3GALNT1 -0.50188499512787 0.00344713341196035 0.613905163989412 0.00100472420696999 miRNAWalker2_validate -0.416037686953911 5.40210677111514e-16 NA NA NA hsa-miR-192-5p B3GNT5 -0.50188499512787 0.00344713341196035 0.793070163988416 0.000903109981778052 miRNAWalker2_validate -0.18254791145049 0.00733849633082143 NA NA NA hsa-miR-148a-3p B4GALT2 -0.748702855596996 3.93313343865641e-07 0.259508874283337 0.00786071208383262 miRNATAP -0.131729353475028 3.23468076819227e-05 NA NA NA hsa-miR-27b-3p B4GALT3 -0.823491817819754 9.20935302746823e-14 0.747431198851972 9.7665978149736e-18 MirTarget;miRNATAP -0.202875337431222 1.39346968332091e-07 NA NA NA hsa-miR-148a-3p B4GALT5 -0.748702855596996 3.93313343865641e-07 -0.523612200569853 3.66546987358603e-06 MirTarget;miRNATAP -0.326881094016732 4.65665310573306e-20 NA NA NA hsa-miR-92a-1-5p BACH2 0.389443191151075 0.0644925359204601 -1.98817818659277 2.20288210770245e-15 MirTarget -0.164430725531321 0.00635400469120093 NA NA NA hsa-miR-148a-3p BAZ2A -0.748702855596996 3.93313343865641e-07 0.461073155925693 4.28128289777929e-08 mirMAP;miRNATAP -0.15432037562048 1.83068832398087e-08 NA NA NA hsa-miR-27b-3p BAZ2A -0.823491817819754 9.20935302746823e-14 0.461073155925693 4.28128289777929e-08 miRNAWalker2_validate -0.109617976290385 0.00278390990591917 NA NA NA hsa-miR-27b-3p BBC3 -0.823491817819754 9.20935302746823e-14 0.804667864310401 1.64815736901645e-10 miRNATAP -0.203869768027322 0.000220938302295931 NA NA NA hsa-miR-192-5p BBS7 -0.50188499512787 0.00344713341196035 0.266690014901358 0.0901347389297157 miRNAWalker2_validate -0.167046709872477 0.000168465158422697 NA NA NA hsa-miR-20a-5p BBX 0.854326758727003 5.04256669663285e-07 -0.0708140126861245 0.5432084569548 MirTarget;miRNATAP -0.178232417606736 3.93270532841047e-08 NA NA NA hsa-miR-27b-3p BBX -0.823491817819754 9.20935302746823e-14 -0.0708140126861245 0.5432084569548 MirTarget;miRNATAP -0.114290335581857 0.0224693178035033 NA NA NA hsa-miR-27b-3p BCAN -0.823491817819754 9.20935302746823e-14 3.24529165288391 1.28551429438288e-16 miRNATAP -0.994538127054223 9.10432325558327e-09 NA NA NA hsa-miR-148a-3p BCL2 -0.748702855596996 3.93313343865641e-07 -0.34630447089245 0.0249701729768122 miRNAWalker2_validate;miRTarBase -0.309765293468013 4.08540378699783e-10 21455217;23975374 MiR 148a promotes apoptosis by targeting Bcl 2 in colorectal cancer;MiR 148a regulates the growth and apoptosis in pancreatic cancer by targeting CCKBR and Bcl 2; Using western blot and luciferase activity assay CCKBR and Bcl-2 were identified as targets of miR-148a; Moreover we also found that the expression of Bcl-2 lacking in 3'UTR could abrogate the pro-apoptosis function of miR-148a ; colorectal cancer;pancreatic cancer hsa-miR-192-5p BCL2 -0.50188499512787 0.00344713341196035 -0.34630447089245 0.0249701729768122 miRNAWalker2_validate -0.343159016245154 5.19113742652329e-16 26550150 MicroRNA 192 regulates chemo resistance of lung adenocarcinoma for gemcitabine and cisplatin combined therapy by targeting Bcl 2; In this paper we try to test whether miR-192 regulates chemo-resistance in human carcinoma A549 mice model by targeting Bcl-2; MTT assay real-time RT-PCR western blotting assay were used to investigate miR-192 expression levels cell viability ratio and Bcl-2 protein expression levels; Bcl-2 mRNA and protein expression levels up-regulated in miR-192 inhibitor treated tumor; Bcl-2 is a key regulator for miR-192 related chemotherapy resistance; In this study we demonstrate that miR-192 regulates chemoresistance for gemcitabine and cisplatin combined chemotherapy in human adenocarcinoma lung cancer A549 cells and Bcl-2 is the target of miR-192 drug resistance lung cancer hsa-miR-20a-5p BCL2 0.854326758727003 5.04256669663285e-07 -0.34630447089245 0.0249701729768122 miRNAWalker2_validate;miRTarBase -0.309280985956287 4.00465486003896e-13 NA NA NA hsa-miR-148a-3p BCL9L -0.748702855596996 3.93313343865641e-07 0.488893976862282 7.48836967061567e-05 mirMAP -0.252714926187226 2.14292604768469e-10 NA NA NA hsa-miR-27b-3p BEND3 -0.823491817819754 9.20935302746823e-14 1.01774373383669 5.6745626823253e-12 miRNATAP -0.128868398452988 0.048950430621724 NA NA NA hsa-miR-27b-3p BEST1 -0.823491817819754 9.20935302746823e-14 0.397419440138162 0.0452322711716492 MirTarget -0.248426334905831 0.00366561485110677 NA NA NA hsa-miR-192-5p BHLHE22 -0.50188499512787 0.00344713341196035 -1.8780713907135 1.9887576917688e-08 MirTarget;miRNATAP -0.517404829760929 5.59541756379103e-08 NA NA NA hsa-miR-148a-3p BHLHE41 -0.748702855596996 3.93313343865641e-07 -0.40186061667449 0.159058094290555 MirTarget -0.822231025139073 2.60286252642047e-20 NA NA NA hsa-miR-20a-5p BHLHE41 0.854326758727003 5.04256669663285e-07 -0.40186061667449 0.159058094290555 miRNATAP -0.42796250951698 8.21856768874901e-08 NA NA NA hsa-miR-192-5p BICD1 -0.50188499512787 0.00344713341196035 0.798278862498021 0.000395688075323181 miRNAWalker2_validate -0.457941514727123 2.37513682930315e-13 NA NA NA hsa-let-7b-5p BIRC5 -0.959013717270803 5.95127281258643e-11 4.49515004999251 9.61981227851246e-50 miRNAWalker2_validate -0.714894665750299 6.76492235439612e-11 NA NA NA hsa-miR-101-3p BIRC5 -1.48176407980989 3.98950707385704e-31 4.49515004999251 9.61981227851246e-50 miRNAWalker2_validate -1.3265120823297 7.97415084582345e-32 NA NA NA hsa-miR-10a-5p BIRC5 -1.47723516092033 7.27299669108673e-16 4.49515004999251 9.61981227851246e-50 miRNAWalker2_validate -0.713644309178663 4.2990229259411e-17 NA NA NA hsa-miR-203a-3p BIRC5 -1.34362479226226 8.69374456831293e-05 4.49515004999251 9.61981227851246e-50 miRTarBase -0.125858297754976 0.00935408966011575 22713668;27714672 Luciferase assays were also performed to validate BIRC5 and LASP1 as miR-203 targets; Both miR-203 and BIRC5 siRNA signicantly inhibited cell proliferation in TNBC cells; Moreover up-regulated of BIRC5 and LASP1 was able to abrogate the effects induced by transfection with the miR-203 precursor;miR 203 is a predictive biomarker for colorectal cancer and its expression is associated with BIRC5; The purpose of this study was to explore the role of miR-203 in colorectal cancer CRC and evaluate the correlation between miR-203 and BIRC5; Finally miR-203 expression was negatively associated with that of BIRC5 r = -0.8150 P < 0.05 ; breast cancer;colorectal cancer hsa-miR-218-5p BIRC5 -0.500091158894849 0.0398595700240766 4.49515004999251 9.61981227851246e-50 miRTarBase;MirTarget -0.141730591808928 0.0393259754882198 25473903;25900794;26442524 Survivin BIRC5 was subsequently identified as an important cervical cancer target of miR-218 using in silico prediction mRNA profiling and quantitative real-time PCR qRT-PCR;miR-218 binds survivin BIRC5 mRNA 3'-UTR and down-regulated reporter luciferase activity;MiR-218 promoted apoptosis inhibited cell proliferation and caused cell cycle arrest in CRC cells by suppressing BIRC5 expression; In conclusion we demonstrated that high miR-218 expression had a positive prognostic value in 5-FU-based treatments for CRC patients and discovered a novel mechanism mediated by miR-218 to promote apoptosis and to function synergistically with 5-FU to promote chemosensitivity by suppressing BIRC5 and TS in CRC ;; cervical and endocervical cancer;breast cancer;colorectal cancer hsa-miR-30c-5p BIRC5 -0.432111642767632 0.000159764714931007 4.49515004999251 9.61981227851246e-50 miRNAWalker2_validate -0.45333717178008 0.00191124919706276 NA NA NA hsa-miR-335-5p BIRC5 -1.61347836513558 1.62757083289711e-19 4.49515004999251 9.61981227851246e-50 miRNAWalker2_validate;MirTarget -0.501439997555754 1.3266718457985e-08 23232114 Genetic variation in a miR 335 binding site in BIRC5 alters susceptibility to lung cancer in Chinese Han populations; In support of the postulation that the 3' UTR SNP may directly affect miRNA-binding site reporter gene assays indicated BIRC5 was a direct target of miR-335 and the rs2239680 T>C change resulted in altered regulation of BIRC5 expression; Our findings defined a 3' UTR SNP in human BIRC5 oncogene that may increase individual susceptibility to lung cancer probably by attenuating the interaction between miR-335 and BIRC5 lung cancer hsa-miR-542-3p BIRC5 -1.31351015149842 3.64642423288576e-22 4.49515004999251 9.61981227851246e-50 miRNAWalker2_validate;MirTarget;miRanda -0.82408325426437 5.64539118201001e-13 NA NA NA hsa-miR-192-5p BLM -0.50188499512787 0.00344713341196035 2.50912465937782 1.07866310951508e-24 miRNAWalker2_validate -0.204767671899931 0.00540874533709116 NA NA NA hsa-miR-148a-3p BMF -0.748702855596996 3.93313343865641e-07 0.478799554865222 0.0182321819658814 mirMAP -0.313554651598086 1.85985160484412e-06 NA NA NA hsa-miR-92a-1-5p BMP1 0.389443191151075 0.0644925359204601 -0.409493388556717 0.00096398049769483 mirMAP -0.196559484879421 2.96257781132342e-12 NA NA NA hsa-miR-192-5p BMP2K -0.50188499512787 0.00344713341196035 -0.818475794333253 1.85957627715201e-10 miRNAWalker2_validate -0.161167657397344 1.27324072367936e-05 NA NA NA hsa-miR-20a-5p BMPR2 0.854326758727003 5.04256669663285e-07 -0.735692104466334 2.00485450351153e-12 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.240712956475078 2.24570589605185e-16 NA NA NA hsa-miR-20a-5p BNC2 0.854326758727003 5.04256669663285e-07 -0.388487485712339 0.0897285209798168 miRNATAP -0.360035085736884 1.7918056419551e-08 NA NA NA hsa-miR-20a-5p BNIP3L 0.854326758727003 5.04256669663285e-07 -0.67007493110919 3.59838811073751e-10 MirTarget -0.198826101982103 4.67122584810606e-11 NA NA NA hsa-miR-27b-3p BRSK1 -0.823491817819754 9.20935302746823e-14 1.81105177787136 9.45669167882099e-16 MirTarget;miRNATAP -0.597414449434798 1.59945390904914e-09 NA NA NA hsa-miR-27b-3p BRSK2 -0.823491817819754 9.20935302746823e-14 1.39040613056321 0.000399787455740901 MirTarget;miRNATAP -0.678037735755323 6.27192410895021e-05 NA NA NA hsa-miR-27b-3p BSN -0.823491817819754 9.20935302746823e-14 0.943588815475765 2.35563209281755e-05 mirMAP -0.19100696376582 0.0494604809951741 NA NA NA hsa-miR-148a-3p BTBD10 -0.748702855596996 3.93313343865641e-07 0.283901647603299 2.32887164783357e-05 MirTarget;miRNATAP -0.173605296764223 2.61734389373406e-16 NA NA NA hsa-miR-148a-3p BTBD3 -0.748702855596996 3.93313343865641e-07 0.299640501202244 0.00861061458292312 miRNAWalker2_validate;miRNATAP -0.165809468768616 7.41091066221071e-06 NA NA NA hsa-miR-192-5p BTF3L4 -0.50188499512787 0.00344713341196035 -0.100360507081779 0.172074476918219 miRNAWalker2_validate -0.122110499991506 1.94924301637388e-09 NA NA NA hsa-miR-20a-5p BTN3A1 0.854326758727003 5.04256669663285e-07 0.334169263969577 0.0147772190819653 miRNAWalker2_validate -0.20556452967795 8.45055210241498e-08 NA NA NA hsa-miR-139-5p BUB1 -2.11299531796557 8.16407076415038e-28 4.04762666744344 9.60341711300894e-48 miRanda -0.981222586322315 6.07995380621313e-51 NA NA NA hsa-miR-199a-5p BUB1 -1.98848462405923 2.0421622713753e-11 4.04762666744344 9.60341711300894e-48 miRanda -0.291631300567174 3.71128271880203e-09 NA NA NA hsa-miR-542-3p BUB1 -1.31351015149842 3.64642423288576e-22 4.04762666744344 9.60341711300894e-48 miRanda -0.668988733252235 2.14129391171968e-10 NA NA NA hsa-miR-142-3p BUB1B -1.4243101967815 1.92609481097765e-14 3.85682830100864 2.02974032557381e-43 miRanda -0.198560838022744 0.0119274709130208 NA NA NA hsa-miR-192-5p BUB1B -0.50188499512787 0.00344713341196035 3.85682830100864 2.02974032557381e-43 miRNAWalker2_validate -0.221905021279395 0.0119217114033508 NA NA NA hsa-miR-193b-3p BUB1B -0.166697207281748 0.272022543069482 3.85682830100864 2.02974032557381e-43 miRNAWalker2_validate -0.199232903598723 0.0474370924329797 NA NA NA hsa-miR-215-5p BUB1B -0.981544773246509 3.14452272477156e-05 3.85682830100864 2.02974032557381e-43 miRNAWalker2_validate -0.164346842914509 0.0099257038268172 NA NA NA hsa-miR-22-3p BUB1B -0.628561621952407 1.33755558015523e-09 3.85682830100864 2.02974032557381e-43 miRNAWalker2_validate -1.59565755962297 8.34276186949843e-33 NA NA NA hsa-miR-486-5p BUB1B -1.77766890600022 2.9071717929922e-14 3.85682830100864 2.02974032557381e-43 miRanda -0.415413021317956 1.24965935132642e-11 NA NA NA hsa-miR-192-5p BVES -0.50188499512787 0.00344713341196035 -0.598065561585224 0.0036533054063061 mirMAP -0.287669978983438 6.8159832940245e-07 NA NA NA hsa-miR-192-5p C15orf52 -0.50188499512787 0.00344713341196035 0.415956597921443 0.0643992937880854 mirMAP -0.435287965298841 2.66460522560021e-12 NA NA NA hsa-miR-20a-5p C16orf52 0.854326758727003 5.04256669663285e-07 -0.498924156279034 2.0232126667381e-06 miRNATAP -0.177480833579238 1.82259009146111e-09 NA NA NA hsa-miR-20a-5p C16orf70 0.854326758727003 5.04256669663285e-07 -0.765094694813145 5.94169478628678e-11 miRNATAP -0.11381929252027 0.000750228065073346 NA NA NA hsa-miR-148a-3p C1orf116 -0.748702855596996 3.93313343865641e-07 -1.07293974225301 0.00530380557251411 mirMAP -0.613864425757337 8.93655915053795e-07 NA NA NA hsa-miR-27b-3p C20orf194 -0.823491817819754 9.20935302746823e-14 0.238037680827578 0.0793767985288294 miRNATAP -0.178709226168511 0.00218432834509195 NA NA NA hsa-miR-27b-3p C22orf29 -0.823491817819754 9.20935302746823e-14 1.09019898263552 1.10984149710713e-27 mirMAP -0.121191961464524 0.00840991427235954 NA NA NA hsa-miR-20a-5p C2CD2 0.854326758727003 5.04256669663285e-07 0.0379059338335348 0.761740129175128 MirTarget;miRNATAP -0.190500339666864 4.53382021622743e-08 NA NA NA hsa-miR-27b-3p C2CD2 -0.823491817819754 9.20935302746823e-14 0.0379059338335348 0.761740129175128 MirTarget -0.159915185214851 0.00287159314916706 NA NA NA hsa-miR-192-5p C2CD4A -0.50188499512787 0.00344713341196035 0.228212273121767 0.594894906410024 mirMAP -0.27344393042256 0.0246760168528404 NA NA NA hsa-miR-148a-3p C5orf30 -0.748702855596996 3.93313343865641e-07 0.905488139382461 0.000488976635207195 miRNATAP -0.740736014753206 1.17959742896383e-19 NA NA NA hsa-miR-192-5p C6orf223 -0.50188499512787 0.00344713341196035 0.669280204465648 0.189250898670159 mirMAP -0.401154733255861 0.00550023094876772 NA NA NA hsa-miR-192-5p CA12 -0.50188499512787 0.00344713341196035 2.34009290257016 5.88059078525048e-07 mirMAP -0.283610005786242 0.0355075315972785 NA NA NA hsa-miR-20a-5p CA5B 0.854326758727003 5.04256669663285e-07 0.772932318052634 9.14252785241903e-06 mirMAP -0.158603429966099 0.00143335848151017 NA NA NA hsa-miR-192-5p CA8 -0.50188499512787 0.00344713341196035 1.30458530653828 6.77357214311562e-06 miRNAWalker2_validate -0.350278797623789 2.19532146421647e-05 NA NA NA hsa-miR-192-5p CAB39L -0.50188499512787 0.00344713341196035 -0.504869726858055 1.1927547950473e-05 miRNAWalker2_validate -0.168189458314805 2.40399921852626e-07 NA NA NA hsa-miR-192-5p CACNA1C -0.50188499512787 0.00344713341196035 0.946440250430891 1.06436399202531e-05 mirMAP -0.485416252348342 3.06182549190867e-16 NA NA NA hsa-miR-148a-3p CACNA1E -0.748702855596996 3.93313343865641e-07 1.61336046300478 3.88892981462269e-05 mirMAP -0.551916698525026 1.72909128498258e-05 NA NA NA hsa-miR-92a-1-5p CACNA1I 0.389443191151075 0.0644925359204601 0.68856788879411 0.0811087983044381 mirMAP -0.193252877189591 0.0352217303388282 NA NA NA hsa-miR-27b-3p CACNA2D3 -0.823491817819754 9.20935302746823e-14 0.363185883059655 0.207081897289803 miRNATAP -0.246050693953525 0.047645269677538 NA NA NA hsa-miR-20a-5p CALD1 0.854326758727003 5.04256669663285e-07 -0.530621733887527 1.64156095327975e-08 miRNATAP -0.195440267483236 9.46993586193112e-14 NA NA NA hsa-miR-27b-3p CALM3 -0.823491817819754 9.20935302746823e-14 0.208010932671678 0.0152703300792942 miRNAWalker2_validate;miRNATAP -0.106848099385636 0.00371755816496827 NA NA NA hsa-miR-20a-5p CAMTA2 0.854326758727003 5.04256669663285e-07 -0.349513498841022 7.64783665378357e-05 MirTarget -0.108244239607943 1.44349782249415e-05 NA NA NA hsa-miR-27b-3p CAPZA1 -0.823491817819754 9.20935302746823e-14 0.0745832397420099 0.287801594621395 miRNATAP -0.108511153217582 0.00028298026400426 NA NA NA hsa-miR-20a-5p CASC4 0.854326758727003 5.04256669663285e-07 -0.459665382720857 2.26052627896481e-06 MirTarget -0.190542702668712 2.01557220224231e-12 NA NA NA hsa-miR-20a-5p CASK 0.854326758727003 5.04256669663285e-07 0.42777049580758 0.000114042576949703 mirMAP -0.195138172194598 2.93563218335273e-10 NA NA NA hsa-miR-148a-3p CASZ1 -0.748702855596996 3.93313343865641e-07 0.0447027176865755 0.759254760507176 miRNATAP -0.216249768226474 4.51223951061093e-06 NA NA NA hsa-miR-20a-5p CAV1 0.854326758727003 5.04256669663285e-07 0.178366589482821 0.179773451413996 miRNATAP -0.170609324845359 4.77162158971638e-06 NA NA NA hsa-miR-20a-5p CAV2 0.854326758727003 5.04256669663285e-07 -0.672599196640157 0.00154731555861785 mirMAP -0.330641103023048 2.91883907245052e-08 NA NA NA hsa-miR-148a-3p CBFA2T2 -0.748702855596996 3.93313343865641e-07 1.20918131407154 1.46538376039906e-30 mirMAP -0.144699434906485 8.4503321462579e-05 NA NA NA hsa-miR-27b-3p CBFB -0.823491817819754 9.20935302746823e-14 -0.0303437811013678 0.730639909137883 MirTarget;miRNATAP -0.190189250108295 3.5255897516604e-07 NA NA NA hsa-miR-192-5p CBL -0.50188499512787 0.00344713341196035 0.0549640409712908 0.654706328872111 mirMAP -0.235199499067807 3.95863847644446e-12 NA NA NA hsa-miR-20a-5p CBLN4 0.854326758727003 5.04256669663285e-07 -1.66592302163761 0.000149471902398456 miRNATAP -0.545376138945613 1.18811195586234e-05 NA NA NA hsa-miR-148a-3p CBX5 -0.748702855596996 3.93313343865641e-07 0.352720475583158 0.00158496538783418 mirMAP -0.154538700330372 2.1011094438904e-05 NA NA NA hsa-miR-20a-5p CBX7 0.854326758727003 5.04256669663285e-07 -0.0772822295902893 0.529369946505877 mirMAP -0.169835367216151 7.64538648057388e-07 NA NA NA hsa-miR-20a-5p CC2D1A 0.854326758727003 5.04256669663285e-07 0.260393841917763 0.00868880391181539 MirTarget;miRNATAP -0.119133698059461 1.97701215858317e-05 NA NA NA hsa-miR-20a-5p CCBE1 0.854326758727003 5.04256669663285e-07 -5.45607436300535 1.74314530465254e-46 mirMAP -0.637723276198193 1.01620399244815e-07 NA NA NA hsa-miR-20a-5p CCDC103 0.854326758727003 5.04256669663285e-07 -0.0347332024261309 0.842632159365499 mirMAP -0.139448497133698 0.00479910785515642 NA NA NA hsa-miR-148a-3p CCDC6 -0.748702855596996 3.93313343865641e-07 0.0486288224569229 0.487131811557696 MirTarget -0.162224288737069 1.91367643340457e-13 NA NA NA hsa-miR-148a-3p CCDC85A -0.748702855596996 3.93313343865641e-07 0.737521480033408 9.22662034200037e-05 miRNATAP -0.162313393513611 0.00894922650017325 NA NA NA hsa-miR-192-5p CCL3L1 -0.50188499512787 0.00344713341196035 -0.813822110806966 0.00487501953312684 miRNAWalker2_validate -0.283347648837424 0.000550015023804458 NA NA NA hsa-let-7a-3p CCNA2 -0.568717557554068 1.00947202557819e-07 3.36794922367745 6.53886370047174e-43 MirTarget -0.508034164420555 3.65278492221913e-05 NA NA NA hsa-let-7b-3p CCNA2 -1.21979213547786 5.84575581584603e-17 3.36794922367745 6.53886370047174e-43 MirTarget -0.732605840868638 4.54728817669008e-18 NA NA NA hsa-let-7b-5p CCNA2 -0.959013717270803 5.95127281258643e-11 3.36794922367745 6.53886370047174e-43 miRNAWalker2_validate;miRTarBase -0.524638048172729 1.97837367658696e-09 NA NA NA hsa-let-7f-1-3p CCNA2 -0.704017923073338 7.84883628944999e-07 3.36794922367745 6.53886370047174e-43 MirTarget -0.411800166097723 9.61755775465089e-06 NA NA NA hsa-miR-130a-3p CCNA2 -1.53229181736223 2.91460363624872e-19 3.36794922367745 6.53886370047174e-43 miRNATAP -0.393381177440701 9.03577520347484e-08 NA NA NA hsa-miR-199a-5p CCNA2 -1.98848462405923 2.0421622713753e-11 3.36794922367745 6.53886370047174e-43 miRanda -0.274665722447149 1.39754779993059e-10 NA NA NA hsa-miR-22-3p CCNA2 -0.628561621952407 1.33755558015523e-09 3.36794922367745 6.53886370047174e-43 MirTarget -1.21746436700899 3.56641376559019e-24 25596928 The sequence of miR-22 which is conserved in mice rats humans and other mammalians aligns with the sequence of 3'-UTR of CCNA2; Chenodeoxycholic acid treatment and miR-22 mimics reduced CCNA2 protein and increased the number of G0/G1 Huh7 and HCT116 cells; In humans the expression levels of miR-22 and CCNA2 are inversely correlated in liver and colon cancers liver cancer hsa-miR-27b-3p CCNA2 -0.823491817819754 9.20935302746823e-14 3.36794922367745 6.53886370047174e-43 miRNATAP -0.54120082992627 3.46716161944693e-06 NA NA NA hsa-miR-29a-3p CCNA2 -0.856762511178136 4.65330336378459e-12 3.36794922367745 6.53886370047174e-43 MirTarget -0.878689289923181 3.31167697738131e-18 NA NA NA hsa-miR-29b-1-5p CCNA2 -0.538946836809295 0.00102913307251186 3.36794922367745 6.53886370047174e-43 MirTarget -0.331466426463458 3.78367154695011e-05 NA NA NA hsa-miR-29b-3p CCNA2 -0.348885528720517 0.0121441341291285 3.36794922367745 6.53886370047174e-43 MirTarget -0.589199607558879 3.67803340321416e-10 NA NA NA hsa-miR-29c-3p CCNA2 -1.4367517608807 1.61767774905781e-21 3.36794922367745 6.53886370047174e-43 MirTarget -0.922743011617596 1.63915073620724e-32 NA NA NA hsa-miR-374b-5p CCNA2 -0.307538028546424 0.0030079617545972 3.36794922367745 6.53886370047174e-43 mirMAP -0.32681314307052 0.0114301592113977 NA NA NA hsa-miR-486-5p CCNA2 -1.77766890600022 2.9071717929922e-14 3.36794922367745 6.53886370047174e-43 miRanda -0.275730733902838 4.10950790707083e-07 NA NA NA hsa-let-7b-5p CCNB1 -0.959013717270803 5.95127281258643e-11 3.15540953438863 5.73583669464518e-46 miRNAWalker2_validate -0.536702047843919 1.21768540248182e-11 NA NA NA hsa-miR-139-5p CCNB1 -2.11299531796557 8.16407076415038e-28 3.15540953438863 5.73583669464518e-46 miRanda -0.800903870286373 3.33153076219979e-55 NA NA NA hsa-miR-142-5p CCNB1 -1.44575553250033 1.18797044680592e-13 3.15540953438863 5.73583669464518e-46 MirTarget -0.146430294535015 0.0152842140616675 NA NA NA hsa-miR-20a-5p CCND1 0.854326758727003 5.04256669663285e-07 -0.901747452525989 1.22363850855738e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.332506713675419 1.04479750525145e-08 NA NA NA hsa-miR-20a-5p CCND2 0.854326758727003 5.04256669663285e-07 0.356451160382274 0.0365641518216489 miRNAWalker2_validate;miRTarBase;miRNATAP -0.156120931730772 0.0012098497067071 NA NA NA hsa-miR-27b-3p CCND3 -0.823491817819754 9.20935302746823e-14 0.0767102129984094 0.478427267753328 miRNAWalker2_validate -0.236832359235505 2.50262257150465e-07 NA NA NA hsa-miR-192-5p CCNE1 -0.50188499512787 0.00344713341196035 3.04640353472202 4.5986250804531e-28 miRNAWalker2_validate -0.353990461529605 2.35568212305901e-05 NA NA NA hsa-miR-192-5p CCNO -0.50188499512787 0.00344713341196035 1.78909423167233 1.94025068480648e-05 miRNAWalker2_validate -0.510543705454595 1.817952514309e-05 NA NA NA hsa-miR-148a-3p CCT6A -0.748702855596996 3.93313343865641e-07 0.807199846325453 3.99983471227829e-24 MirTarget -0.142589901920738 1.49586171325104e-07 NA NA NA hsa-miR-20a-5p CD274 0.854326758727003 5.04256669663285e-07 -1.27197015327625 1.91338057077084e-08 MirTarget;miRNATAP -0.419422834501942 5.11594503516805e-11 NA NA NA hsa-miR-27b-3p CD28 -0.823491817819754 9.20935302746823e-14 0.296648468301709 0.11433598708989 miRNATAP -0.207263340327522 0.010451315584138 NA NA NA hsa-miR-27b-3p CD44 -0.823491817819754 9.20935302746823e-14 -0.0861213298199726 0.717927779502077 miRNATAP -0.346982595786675 0.000695530690953447 NA NA NA hsa-miR-20a-5p CD69 0.854326758727003 5.04256669663285e-07 -1.74691450716 3.50683306201239e-12 miRNATAP -0.219544994735417 0.00264853195477804 NA NA NA hsa-miR-192-5p CD83 -0.50188499512787 0.00344713341196035 -0.752923537233197 3.68171723467509e-07 miRNAWalker2_validate -0.15847156507221 0.000182702809873103 NA NA NA hsa-miR-192-5p CD93 -0.50188499512787 0.00344713341196035 0.152893293585773 0.246481042677798 MirTarget -0.232543254915553 2.08107954892632e-10 NA NA NA hsa-miR-192-5p CDC20 -0.50188499512787 0.00344713341196035 4.43876134810924 2.33731245396441e-49 miRNAWalker2_validate -0.257887721839452 0.00747315576024174 NA NA NA hsa-miR-215-5p CDC20 -0.981544773246509 3.14452272477156e-05 4.43876134810924 2.33731245396441e-49 miRNAWalker2_validate -0.210290018213749 0.00250187708869541 NA NA NA hsa-miR-23b-3p CDC20 -0.530561587109023 5.43807206823652e-07 4.43876134810924 2.33731245396441e-49 miRNAWalker2_validate -0.727746315213922 2.45876854567768e-06 NA NA NA hsa-miR-30a-5p CDC20 -0.626257932887855 0.000108198196973765 4.43876134810924 2.33731245396441e-49 miRNAWalker2_validate -0.686824996889202 5.1373930712059e-12 NA NA NA hsa-miR-29c-3p CDC23 -1.4367517608807 1.61767774905781e-21 0.463635495366116 5.65757358389337e-10 miRNAWalker2_validate -0.137258097204054 2.34594396923131e-09 NA NA NA hsa-miR-148a-3p CDC25B -0.748702855596996 3.93313343865641e-07 0.802575978153976 1.68584041760539e-08 miRNAWalker2_validate;miRNATAP -0.29297329943429 2.56785527501486e-10 25341915 Gene CDC25B might be the target gene of miR-148a according to the results of targetscan; CDC25B may be the target gene of miR-148a that plays a role in tumor suppressor gastric cancer hsa-miR-27b-3p CDC25B -0.823491817819754 9.20935302746823e-14 0.802575978153976 1.68584041760539e-08 miRNATAP -0.298569829692256 1.30532384058526e-06 NA NA NA hsa-miR-20a-5p CDC37L1 0.854326758727003 5.04256669663285e-07 -1.68074286794396 1.35044263041101e-36 MirTarget;miRNATAP -0.321174697738291 7.5246516441106e-16 NA NA NA hsa-miR-192-5p CDC7 -0.50188499512787 0.00344713341196035 2.01751950910415 4.47781393592943e-28 miRNAWalker2_validate -0.19830872980512 0.000359320910618898 NA NA NA hsa-miR-192-5p CDCA4 -0.50188499512787 0.00344713341196035 1.27278228859461 1.15861071696374e-22 miRNAWalker2_validate -0.170399204355543 9.94973963518653e-06 NA NA NA hsa-miR-146b-5p CDH1 0.419719546795449 0.0457375823220155 -0.925620688902025 3.54334396234e-05 miRanda -0.209827116364557 5.56204266800899e-05 NA NA NA hsa-miR-185-5p CDH1 0.480006257154717 6.35758891340152e-07 -0.925620688902025 3.54334396234e-05 MirTarget -0.447644587025903 7.92400318750844e-05 27212161;24025511 We also found that ectopic expression of miR-185 reversed EMT via the up-regulation of E-cadherin and down-regulation of vimentin in epithelial and mesenchymal HCC cells;After transfection of miR-185 inhibitor into KYSE30 the expression of E-cadherin a downstream protein of Six1 was observed under confocal microscope; After transfection of miR-185 inhibitorthe expression level of E-cadherin decreased ; liver cancer;esophageal cancer hsa-miR-186-5p CDH1 -0.060103391373687 0.535288717081205 -0.925620688902025 3.54334396234e-05 mirMAP -0.271690734682459 0.0182700262180118 NA NA NA hsa-miR-616-5p CDH1 0.150569904638223 0.402836556304524 -0.925620688902025 3.54334396234e-05 MirTarget;mirMAP -0.142138556800114 0.0208629153342258 NA NA NA hsa-miR-27b-3p CDH24 -0.823491817819754 9.20935302746823e-14 2.17913448396389 2.09594267152664e-31 miRNATAP -0.38655213215607 7.56658561897812e-06 NA NA NA hsa-miR-139-5p CDK1 -2.11299531796557 8.16407076415038e-28 3.60092865588574 2.53758251358007e-48 miRanda -0.838938956041355 1.17302084660509e-46 NA NA NA hsa-miR-193b-3p CDK1 -0.166697207281748 0.272022543069482 3.60092865588574 2.53758251358007e-48 miRNAWalker2_validate -0.247245044417844 0.00581826116259039 NA NA NA hsa-miR-195-3p CDK1 -1.09375690196245 4.70092324819807e-09 3.60092865588574 2.53758251358007e-48 MirTarget -0.373417267400659 1.70004237381144e-07 NA NA NA hsa-miR-378a-5p CDK1 -1.58667444700188 3.19640857320504e-17 3.60092865588574 2.53758251358007e-48 MirTarget -0.547488328475554 2.76743919236473e-16 NA NA NA hsa-miR-486-5p CDK1 -1.77766890600022 2.9071717929922e-14 3.60092865588574 2.53758251358007e-48 miRanda -0.358602044004862 6.63525634192938e-11 NA NA NA hsa-miR-148a-3p CDK19 -0.748702855596996 3.93313343865641e-07 0.118030592068031 0.294061978811636 miRNAWalker2_validate;MirTarget;miRNATAP -0.236428879384442 4.30907764913248e-11 NA NA NA hsa-miR-148a-3p CDK5R1 -0.748702855596996 3.93313343865641e-07 1.08475307136185 2.13782053288791e-11 MirTarget;miRNATAP -0.168450901534998 0.00186813487415298 NA NA NA hsa-miR-27b-3p CDK5R1 -0.823491817819754 9.20935302746823e-14 1.08475307136185 2.13782053288791e-11 miRNATAP -0.252961308884038 0.000387463806986018 NA NA NA hsa-miR-20a-5p CDK6 0.854326758727003 5.04256669663285e-07 -0.306731100792328 0.220566158555725 mirMAP -0.336108073900107 1.71022894952879e-06 NA NA NA hsa-miR-139-5p CDK7 -2.11299531796557 8.16407076415038e-28 0.491707717966495 7.16261478943003e-09 miRanda -0.14310504808171 4.57209013484235e-13 NA NA NA hsa-miR-542-3p CDK7 -1.31351015149842 3.64642423288576e-22 0.491707717966495 7.16261478943003e-09 miRanda -0.177460362938327 8.63098208373725e-10 NA NA NA hsa-miR-590-3p CDK7 -0.473167498047808 1.76652934637227e-05 0.491707717966495 7.16261478943003e-09 miRanda -0.178615786936345 2.1764183873582e-06 NA NA NA hsa-miR-20a-5p CDKN1A 0.854326758727003 5.04256669663285e-07 -0.769088197669944 5.80039048047741e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.281025701374886 1.92150921220327e-07 26012475 Using the poorly tumorigenic and TGF-β-sensitive FET cell line that expresses low miR-20a levels we first confirmed that miR-20a downmodulated CDKN1A expression both at mRNA and protein level through direct binding to its 3'-UTR; Moreover besides modulating CDKN1A miR-20a blocked TGF-β-induced transactivation of its promoter without affecting the post-receptor activation of Smad3/4 effectors directly; Finally miR-20a abrogated the TGF-β-mediated c-Myc repression a direct inhibitor of the CDKN1A promoter activation most likely by reducing the expression of specific MYC-regulating genes from the Smad/E2F-based core repressor complex colon cancer hsa-miR-181a-5p CDKN1B 0.250113435902954 0.0551933249319293 -0.231452033928625 0.00482071055692889 miRNAWalker2_validate;miRTarBase -0.134068475887496 1.13890102336643e-05 NA NA NA hsa-miR-221-3p CDKN1B 1.12244756358612 3.48370308238012e-13 -0.231452033928625 0.00482071055692889 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.153438831523776 5.56071406720925e-10 20146005;23637992;19953484;23939688;19126397;23967190;17569667;22992757;17721077;20461750 Matched HCC and adjacent non-cancerous samples were assayed for the expression of miR-221 and three G1/S transition inhibitors: p27Kip1 p21WAF1/Cip1and TGF-β1 by in situ hybridization and immunohistochemistry respectively; Real time qRT-PCR was used to investigate miR-221 and p27Kip1 transcripts in different clinical stages; In result miR-221 and TGF-β1 are frequently up-regulated in HCC while p27Kip1 and p21WAF1/Cip1 proteins are frequently down-regulated; In conclusion miR-221 is important in tumorigenesis of HCC possibly by specifically down-regulating p27Kip1 a cell-cycle inhibitor;miR-221 knockdown not only blocked cell cycle progression induced cell apoptosis and inhibited cell proliferation in-vitro but it also inhibited in-vivo tumor growth by targeting p27kip1;Based on bioinformatic analysis we found that the seed sequences of miR-221 and miR-222 coincide with each other and p27kip1 is a target for miRNA-221/222;A Slug/miR-221 network has been suggested linking miR-221 activity with the downregulation of a Slug repressor leading to Slug/miR-221 upregulation and p27Kip1 downregulation; Interference with this process can be achieved using antisense miRNA antagomiR molecules targeting miR-221 inducing the downregulation of Slug and the upregulation of p27Kip1;Moreover a series of functional assays demonstrated that mir-221 could directly inhibit cKit p27Kip1 and possibly other pivotal proteins in melanoma;Additionally the PDGF-dependent increase in cell proliferation appears to be mediated by inhibition of a specific target of miR-221 and down-regulation of p27Kip1;miR 221 and miR 222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1; In all cell lines tested we show an inverse relationship between the expression of miR-221 and miR-222 and the cell cycle inhibitor p27Kip1; Consistently miR-221 and miR-222 knock-down through antisense LNA oligonucleotides increases p27Kip1 in PC3 cells and strongly reduces their clonogenicity in vitro;Peptide nucleic acids targeting miR 221 modulate p27Kip1 expression in breast cancer MDA MB 231 cells; Targeting miR-221 by PNA resulted in i lowering of the hybridization levels of miR-221 measured by RT-qPCR ii upregulation of p27Kip1 gene expression measured by RT-qPCR and western blot analysis;Antagonism of either microRNA 221 or 222 in glioblastoma cells also caused an increase in p27Kip1 levels and enhanced expression of the luciferase reporter gene fused to the p27Kip1 3'UTR;MiR 221 and MiR 222 alterations in sporadic ovarian carcinoma: Relationship to CDKN1B CDKNIC and overall survival; miR-221 and miR-222 negatively regulate expression of CDKN1B p27 and CDKN1C p57 two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas; In contrast CDKN1B expression was not associated with miR-221 or miR-222 expression staging;tumorigenesis;progression;;;;;;;;poor survival liver cancer;breast cancer;glioblastoma;breast cancer;melanoma;pancreatic cancer;prostate cancer;breast cancer;glioblastoma;ovarian cancer hsa-miR-222-3p CDKN1B 1.08574156066353 1.76407192348131e-11 -0.231452033928625 0.00482071055692889 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.140430207935426 3.56247154847449e-09 19953484;26912358;24895988;24137356;17569667;27282281;20461750 Based on bioinformatic analysis we found that the seed sequences of miR-221 and miR-222 coincide with each other and p27kip1 is a target for miRNA-221/222;Besides microvesicle marker characterization we evidenced that miR-222 exosomal expression mostly reflected its abundance in the cells of origin correctly paralleled by repression of its target genes such as p27Kip1 and induction of the PI3K/AKT pathway thus confirming its functional implication in cancer;MiR-222 plays an important role in the tumorigenesis of CC possibly by specifically down-regulating p27Kip1 and PTEN;miR 222 is upregulated in epithelial ovarian cancer and promotes cell proliferation by downregulating P27kip1; miR-222 upregulation induced an enhancement of ovarian cancer cell proliferation potential possibly by downregulating its target P27Kip1; A bioinformatic analysis showed that the 3'-UTR of the P27Kip1 mRNA contained a highly-conserved putative miR-222 binding site; Luciferase reporter assays demonstrated that P27Kip1 was a direct target of miR-222; Consistently there was an inverse correlation between the P27Kip1 and miR-222 expression levels in the ovarian cancer cell lines and tissues;miR 221 and miR 222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1; In all cell lines tested we show an inverse relationship between the expression of miR-221 and miR-222 and the cell cycle inhibitor p27Kip1; Consistently miR-221 and miR-222 knock-down through antisense LNA oligonucleotides increases p27Kip1 in PC3 cells and strongly reduces their clonogenicity in vitro;miR 222 confers the resistance of breast cancer cells to Adriamycin through suppression of p27kip1 expression; Immunofluorescence showed that miR-222 altered the subcellular location of p27kip1 in nucleus; The results showed that downregulation of miR-222 in MCF-7/Adr increased sensitivity to Adr and Adr-induced apoptosis and arrested the cells in G1 phase accompanied by more expressions of p27kip1 especially in nucleus; Taken together the results found that miR-222 induced Adr-resistance at least in part via suppressing p27kip1 expression and altering its subcellular localization and miR-222 inhibitors could reverse Adr-resistance of breast cancer cells;MiR 221 and MiR 222 alterations in sporadic ovarian carcinoma: Relationship to CDKN1B CDKNIC and overall survival; miR-221 and miR-222 negatively regulate expression of CDKN1B p27 and CDKN1C p57 two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas; In contrast CDKN1B expression was not associated with miR-221 or miR-222 expression ;;tumorigenesis;;;drug resistance;poor survival glioblastoma;melanoma;cervical and endocervical cancer;ovarian cancer;prostate cancer;breast cancer;ovarian cancer hsa-miR-24-3p CDKN1B -0.257825594021966 0.00689742600215061 -0.231452033928625 0.00482071055692889 miRNAWalker2_validate;miRNATAP -0.125575697425242 0.00293958904599202 26847530;26044523 The biological significance of miR-24 expression in prostate cancer cells was assessed by a series of in vitro bioassays and the effect on proposed targets p27 CDKN1B and p16 CDK2NA was investigated;With the bioinformatic method we further identified that p27Kip1 is a direct target of miR-24-3p and its protein level was negatively regulated by miR-24-3p ; prostate cancer;breast cancer hsa-miR-98-5p CDKN1B -0.0487189107419432 0.715911066732548 -0.231452033928625 0.00482071055692889 miRNAWalker2_validate -0.150589087046664 3.98220273478164e-07 NA NA NA hsa-miR-107 CDKN2B 0.241662461253461 0.0170788899505389 1.37191742600332 3.8601745589837e-15 PITA -0.22214715039643 0.0113151536408877 NA NA NA hsa-miR-126-5p CDKN2B -0.428561469405594 6.6035585844222e-05 1.37191742600332 3.8601745589837e-15 mirMAP -0.331524443678709 4.86520309619025e-05 NA NA NA hsa-miR-144-3p CDKN2B -2.97536914478815 6.00546047309683e-28 1.37191742600332 3.8601745589837e-15 MirTarget -0.165363817374004 2.99908004062454e-08 NA NA NA hsa-miR-382-5p CDKN2B -0.71884748690977 0.00849172229801356 1.37191742600332 3.8601745589837e-15 mirMAP -0.101243601276092 0.00159366073719854 NA NA NA hsa-miR-450b-5p CDKN2B -1.34333360369432 2.68386079790462e-17 1.37191742600332 3.8601745589837e-15 mirMAP -0.177653728760579 0.000849213139863512 NA NA NA hsa-miR-451a CDKN2B -2.1025161666445 6.82555767537341e-17 1.37191742600332 3.8601745589837e-15 MirTarget -0.162386705840671 1.05027558906518e-06 NA NA NA hsa-miR-486-5p CDKN2B -1.77766890600022 2.9071717929922e-14 1.37191742600332 3.8601745589837e-15 miRanda -0.19221239071621 9.16912999787263e-08 NA NA NA hsa-miR-450b-5p CDKN2C -1.34333360369432 2.68386079790462e-17 2.08821471271675 1.38541951717446e-30 miRNATAP -0.407319031602086 4.73616061228169e-13 NA NA NA hsa-miR-542-3p CDKN2C -1.31351015149842 3.64642423288576e-22 2.08821471271675 1.38541951717446e-30 miRanda -0.51609932750582 1.59421631749972e-15 NA NA NA hsa-miR-192-5p CDKN2D -0.50188499512787 0.00344713341196035 0.290727219677442 0.00930996537957609 miRNAWalker2_validate -0.138849298331389 1.02446714787693e-05 NA NA NA hsa-miR-148a-3p CDS1 -0.748702855596996 3.93313343865641e-07 -0.320537686923673 0.401665556750745 miRNATAP -0.62382426469952 4.34120367054976e-07 NA NA NA hsa-miR-27b-3p CDYL -0.823491817819754 9.20935302746823e-14 0.406635443252195 1.20554482771922e-07 miRNATAP -0.110850847875399 0.000886736113506495 NA NA NA hsa-miR-20a-5p CELF2 0.854326758727003 5.04256669663285e-07 -0.739701752181153 7.71802060056074e-05 miRNATAP -0.224526709174511 2.33049039740751e-05 NA NA NA hsa-miR-148a-3p CELSR1 -0.748702855596996 3.93313343865641e-07 0.364471201671942 0.107126693908784 MirTarget -0.208015418033919 0.00486931864679582 NA NA NA hsa-miR-192-5p CENPA -0.50188499512787 0.00344713341196035 3.96964552344392 5.7307306371057e-43 miRNAWalker2_validate -0.210866144790898 0.0208834714440388 NA NA NA hsa-miR-192-5p CENPE -0.50188499512787 0.00344713341196035 3.34412617436963 8.3241907160162e-43 miRNAWalker2_validate -0.168885819050718 0.0283464029127194 NA NA NA hsa-miR-192-5p CENPF -0.50188499512787 0.00344713341196035 3.79236503476937 1.25674067170883e-49 miRNAWalker2_validate -0.180264560459754 0.0284939797929093 NA NA NA hsa-miR-192-5p CENPI -0.50188499512787 0.00344713341196035 3.2049585053102 7.34752072975322e-29 miRNAWalker2_validate -0.226734285653858 0.009599189452 NA NA NA hsa-miR-148a-3p CENPP -0.748702855596996 3.93313343865641e-07 1.58562892488644 4.26649488498792e-22 mirMAP -0.152643938238212 0.00690454136350145 NA NA NA hsa-miR-148a-3p CEP55 -0.748702855596996 3.93313343865641e-07 2.874986535696 2.48808404875451e-31 MirTarget -0.761706377152175 6.27881131213199e-20 NA NA NA hsa-miR-192-5p CEP55 -0.50188499512787 0.00344713341196035 2.874986535696 2.48808404875451e-31 miRNAWalker2_validate -0.39326043275467 1.41666164296471e-07 NA NA NA hsa-miR-20a-5p CEP97 0.854326758727003 5.04256669663285e-07 0.291198246303295 0.0718443054357866 MirTarget;miRNATAP -0.122187549811516 0.00766093527928555 NA NA NA hsa-miR-20a-5p CERCAM 0.854326758727003 5.04256669663285e-07 -0.11834200381201 0.648161793551643 MirTarget -0.189904373601208 0.00968204082674771 NA NA NA hsa-miR-20a-5p CFL2 0.854326758727003 5.04256669663285e-07 -1.18046432826413 1.44423082204062e-19 MirTarget;miRNATAP -0.161827805421383 2.54251193863767e-05 NA NA NA hsa-miR-20a-5p CHD9 0.854326758727003 5.04256669663285e-07 -0.511590175184198 2.71332522550186e-05 MirTarget;miRNATAP -0.236626189894067 3.15411664380204e-12 NA NA NA hsa-miR-27b-3p CHKA -0.823491817819754 9.20935302746823e-14 1.03066945671527 4.50639789726118e-14 miRNATAP -0.174426485767567 0.00403524593117461 NA NA NA hsa-miR-148a-3p CHST1 -0.748702855596996 3.93313343865641e-07 0.685732737107354 0.00199386228629166 MirTarget -0.733860751670885 6.4615399196172e-27 NA NA NA hsa-miR-192-5p CHST12 -0.50188499512787 0.00344713341196035 0.217162104581685 0.0165950178679844 miRNAWalker2_validate -0.22511938636416 4.12108652391851e-20 NA NA NA hsa-miR-27b-3p CHST2 -0.823491817819754 9.20935302746823e-14 0.253750766454774 0.0776793157765737 miRNATAP -0.247383741863137 5.90487628803464e-05 NA NA NA hsa-miR-148a-3p CHST3 -0.748702855596996 3.93313343865641e-07 -0.197541925922359 0.301297241668114 mirMAP -0.543542392297203 7.99217300956161e-20 NA NA NA hsa-miR-192-5p CHSY3 -0.50188499512787 0.00344713341196035 -1.1705830419215 8.35489202868046e-09 miRNAWalker2_validate -0.197495798803328 0.00073594034946924 NA NA NA hsa-miR-15a-5p CHUK 0.349521211668244 0.000770735998804736 -0.19932080126218 0.00863163957240649 miRNAWalker2_validate;miRTarBase;MirTarget -0.122536038974783 0.000565424625908096 NA NA NA hsa-miR-15b-5p CHUK 0.230566941413564 0.0824765001857479 -0.19932080126218 0.00863163957240649 MirTarget -0.118017359725558 2.06238744655946e-05 NA NA NA hsa-miR-16-5p CHUK -0.398577235179603 0.000101598495180191 -0.19932080126218 0.00863163957240649 miRNAWalker2_validate;miRTarBase;MirTarget -0.150607357209835 2.62400382273556e-05 NA NA NA hsa-miR-23a-3p CHUK -0.178875974460574 0.135978273540604 -0.19932080126218 0.00863163957240649 MirTarget -0.100438227795724 0.00114468004476388 NA NA NA hsa-miR-339-5p CHUK 0.280589919878422 0.0355660282647215 -0.19932080126218 0.00863163957240649 miRanda -0.12221351609504 8.92727609693918e-06 NA NA NA hsa-miR-590-5p CHUK -0.103355559980404 0.310027295317092 -0.19932080126218 0.00863163957240649 miRanda -0.11766978557823 0.00128889069327197 NA NA NA hsa-miR-192-5p CIB2 -0.50188499512787 0.00344713341196035 1.05115223730211 8.5015227327244e-05 miRNAWalker2_validate -0.376172513964881 6.57490138733288e-07 NA NA NA hsa-miR-148a-3p CIITA -0.748702855596996 3.93313343865641e-07 0.267952742521313 0.180108388943748 mirMAP -0.264823270812163 4.50203150079269e-05 NA NA NA hsa-miR-20a-5p CIITA 0.854326758727003 5.04256669663285e-07 0.267952742521313 0.180108388943748 mirMAP -0.186755125497455 0.000942814576563259 NA NA NA hsa-miR-148a-3p CIT -0.748702855596996 3.93313343865641e-07 0.474922759349472 0.00990742942099617 miRNATAP -0.151727650508733 0.0118981318787957 NA NA NA hsa-miR-27b-3p CIT -0.823491817819754 9.20935302746823e-14 0.474922759349472 0.00990742942099617 miRNATAP -0.170365755132697 0.0323960193359166 NA NA NA hsa-miR-192-5p CKAP4 -0.50188499512787 0.00344713341196035 0.831324304717088 2.24371704954539e-11 miRNAWalker2_validate -0.154306803181703 1.65048180727524e-05 NA NA NA hsa-miR-27b-3p CKAP4 -0.823491817819754 9.20935302746823e-14 0.831324304717088 2.24371704954539e-11 miRNATAP -0.206026894566588 0.000160215157075604 NA NA NA hsa-miR-192-5p CLIC1 -0.50188499512787 0.00344713341196035 0.769904485927027 1.7810853875854e-08 miRNAWalker2_validate -0.233527854498628 1.60324341964638e-09 NA NA NA hsa-miR-20a-5p CLIC6 0.854326758727003 5.04256669663285e-07 -3.64273918141813 1.0632287091366e-18 mirMAP -0.731639335918485 1.11738721848211e-09 NA NA NA hsa-miR-192-5p CLIP4 -0.50188499512787 0.00344713341196035 -0.223789354668674 0.439544374325892 miRNAWalker2_validate -0.383858187296679 2.32080371754578e-06 NA NA NA hsa-miR-20a-5p CLIP4 0.854326758727003 5.04256669663285e-07 -0.223789354668674 0.439544374325892 MirTarget -0.302741686946667 0.000208432298227346 NA NA NA hsa-miR-27b-3p CLK2 -0.823491817819754 9.20935302746823e-14 0.920082317853538 3.42213492570439e-25 miRNATAP -0.100574962788244 0.0130853716960662 NA NA NA hsa-miR-20a-5p CLOCK 0.854326758727003 5.04256669663285e-07 -0.52744295488734 0.00745405676073919 MirTarget -0.283818732522307 2.93587035640901e-07 NA NA NA hsa-miR-192-5p CLSPN -0.50188499512787 0.00344713341196035 2.7969110828425 3.03477840103e-20 miRNAWalker2_validate -0.298993623901868 0.000906240962654405 NA NA NA hsa-miR-192-5p CLSTN1 -0.50188499512787 0.00344713341196035 0.327988364183752 0.0351370589579253 miRNAWalker2_validate -0.336638831802042 3.36297746483766e-15 NA NA NA hsa-miR-20a-5p CMPK1 0.854326758727003 5.04256669663285e-07 -0.676924575484083 5.30937933904552e-18 MirTarget;miRNATAP -0.151343219588845 1.7954021975112e-11 NA NA NA hsa-miR-20a-5p CNDP1 0.854326758727003 5.04256669663285e-07 -6.38507387239177 1.75288227225597e-27 mirMAP -0.706549117006544 6.76377547523147e-05 NA NA NA hsa-miR-148a-3p CNIH4 -0.748702855596996 3.93313343865641e-07 1.00667194671376 1.24728003967923e-20 MirTarget -0.10088285082769 0.00643146069475781 NA NA NA hsa-miR-148a-3p CNN1 -0.748702855596996 3.93313343865641e-07 0.406994515021795 0.0928241685509811 miRNATAP -0.497670787813982 1.39514602371003e-10 NA NA NA hsa-miR-148a-3p CNTN4 -0.748702855596996 3.93313343865641e-07 -2.23654576737969 6.05144113270082e-19 miRNATAP -0.267873351717936 0.00180831931684552 NA NA NA hsa-miR-20a-5p CNTNAP3 0.854326758727003 5.04256669663285e-07 0.106558723996186 0.742851881030026 MirTarget -0.362604672355679 7.34184730089002e-05 NA NA NA hsa-miR-20a-5p COL1A1 0.854326758727003 5.04256669663285e-07 0.826702197173396 0.00648724292232758 mirMAP -0.233621814946948 0.00679703428396713 NA NA NA hsa-miR-148a-3p COL4A1 -0.748702855596996 3.93313343865641e-07 1.64595918385092 3.29766696573805e-22 miRNATAP -0.506696445918838 1.45523526380931e-19 NA NA NA hsa-miR-20a-5p COL4A3 0.854326758727003 5.04256669663285e-07 -0.92673315541801 0.00622463110440454 MirTarget;miRNATAP -0.275914518317586 0.00414348195590725 NA NA NA hsa-miR-192-5p COL5A1 -0.50188499512787 0.00344713341196035 0.157717020532577 0.575064051526938 miRNATAP -0.69106442525522 1.23228181782937e-19 NA NA NA hsa-miR-20a-5p COL8A2 0.854326758727003 5.04256669663285e-07 -0.974645375504798 0.000903968905923106 mirMAP -0.233448175322622 0.00524062360588325 NA NA NA hsa-miR-192-5p CORO2B -0.50188499512787 0.00344713341196035 -0.778344883116467 0.00171267913877174 miRNAWalker2_validate -0.369365150680618 1.2148605675754e-07 NA NA NA hsa-miR-20a-5p CORO2B 0.854326758727003 5.04256669663285e-07 -0.778344883116467 0.00171267913877174 MirTarget;miRNATAP -0.173835235490549 0.013916097836381 NA NA NA hsa-miR-148a-3p CPD -0.748702855596996 3.93313343865641e-07 0.599470550586786 4.65999718552314e-06 MirTarget;miRNATAP -0.141323955894331 0.00103892821521111 NA NA NA hsa-miR-27b-3p CPD -0.823491817819754 9.20935302746823e-14 0.599470550586786 4.65999718552314e-06 miRNATAP -0.244988094196586 1.47465599885245e-05 NA NA NA hsa-miR-20a-5p CPEB3 0.854326758727003 5.04256669663285e-07 -2.73760799365771 6.08365930201296e-43 miRNATAP -0.445462831110694 3.20580969307668e-13 NA NA NA hsa-miR-20a-5p CPEB4 0.854326758727003 5.04256669663285e-07 -1.06097838176943 9.01316045116939e-14 mirMAP -0.221772086536128 6.43257989653563e-08 NA NA NA hsa-miR-27b-3p CPLX2 -0.823491817819754 9.20935302746823e-14 5.16430096205473 2.83212867957316e-12 mirMAP -2.34864563500762 1.65938410416298e-13 NA NA NA hsa-miR-20a-5p CREB5 0.854326758727003 5.04256669663285e-07 0.00174118159445535 0.993131455555257 MirTarget;miRNATAP -0.146915422744345 0.0102509871192745 NA NA NA hsa-miR-20a-5p CRIM1 0.854326758727003 5.04256669663285e-07 -0.427323666964741 0.0396278582056627 miRTarBase;MirTarget;miRNATAP -0.44427476286557 6.87894558189768e-15 NA NA NA hsa-miR-20a-5p CRK 0.854326758727003 5.04256669663285e-07 -0.66019370420832 1.97619097308481e-10 MirTarget;miRNATAP -0.120757871328387 5.13100158700272e-05 NA NA NA hsa-miR-20a-5p CRYBG3 0.854326758727003 5.04256669663285e-07 -0.701440679666375 0.0115118986767452 MirTarget;miRNATAP -0.482353837183608 4.55438910089713e-10 NA NA NA hsa-miR-148a-3p CS -0.748702855596996 3.93313343865641e-07 0.630496195920363 1.14583127791941e-12 miRNATAP -0.1545115311895 1.37525350059388e-07 NA NA NA hsa-miR-148a-3p CSF1 -0.748702855596996 3.93313343865641e-07 -0.5853277886696 0.00153229238014141 miRNATAP -0.256768312227477 2.00461329540934e-05 NA NA NA hsa-miR-20a-5p CSF1 0.854326758727003 5.04256669663285e-07 -0.5853277886696 0.00153229238014141 miRNATAP -0.281846084837308 5.48117776284526e-08 NA NA NA hsa-miR-20a-5p CSGALNACT1 0.854326758727003 5.04256669663285e-07 0.194748522387815 0.229122552908902 MirTarget -0.208588980914546 4.42121116516048e-06 NA NA NA hsa-miR-148a-3p CSPG4 -0.748702855596996 3.93313343865641e-07 2.20938998217354 1.93186590158878e-35 miRNATAP -0.47109794771531 1.88996499141413e-14 NA NA NA hsa-miR-330-3p CTNNB1 -0.332364259424489 0.0316051913061459 0.00180452674840392 0.983564078864382 MirTarget;PITA;miRNATAP -0.128940103294471 3.76576237893285e-06 NA NA NA hsa-miR-331-3p CTNNB1 -0.283974346994635 0.0373785411053202 0.00180452674840392 0.983564078864382 miRNAWalker2_validate -0.113207881387487 0.000273720190926097 NA NA NA hsa-miR-148a-3p CTTNBP2NL -0.748702855596996 3.93313343865641e-07 0.0265420118187079 0.819395334474897 MirTarget;miRNATAP -0.400219991755329 7.16863410683787e-30 NA NA NA hsa-miR-27a-3p CUL1 -0.370807380415112 0.00875721956202713 -0.117901782494851 0.10228448838388 miRNAWalker2_validate -0.100449098638373 4.43211535246804e-05 NA NA NA hsa-miR-30b-5p CUL2 -0.54056186708617 2.44688760798341e-05 0.221493309659475 0.000775493336759859 MirTarget;mirMAP;miRNATAP -0.104130690012811 2.59410967342164e-05 NA NA NA hsa-miR-27b-3p CUL4B -0.823491817819754 9.20935302746823e-14 0.321392957566996 8.06539050055239e-06 miRNAWalker2_validate -0.106007625746476 0.000643446334148388 NA NA NA hsa-miR-92a-1-5p CUX1 0.389443191151075 0.0644925359204601 -0.187927348104609 0.0398134377996123 mirMAP -0.126645657772578 1.07490096056749e-09 NA NA NA hsa-miR-20a-5p CXCL6 0.854326758727003 5.04256669663285e-07 -3.43495201431017 2.61831723964962e-09 MirTarget -0.840433867564058 3.46698534970176e-07 NA NA NA hsa-miR-20a-5p CXorf23 0.854326758727003 5.04256669663285e-07 0.430761186308626 9.49129189428509e-06 mirMAP -0.10083578676636 0.000265555846338066 NA NA NA hsa-miR-20a-5p CXorf38 0.854326758727003 5.04256669663285e-07 -0.20690073441604 0.0251657719260332 mirMAP -0.127422909367595 8.33539229786413e-07 NA NA NA hsa-miR-192-5p CYB561D1 -0.50188499512787 0.00344713341196035 1.35618855619484 4.53684308721849e-24 mirMAP -0.202495820420795 3.58922576334244e-07 NA NA NA hsa-miR-192-5p CYBRD1 -0.50188499512787 0.00344713341196035 -1.29333537908526 9.44725361000613e-10 mirMAP -0.300732503720988 6.7769310823661e-07 NA NA NA hsa-miR-20a-5p CYBRD1 0.854326758727003 5.04256669663285e-07 -1.29333537908526 9.44725361000613e-10 MirTarget -0.366559433107161 1.03284392805768e-09 NA NA NA hsa-miR-20a-5p CYP2U1 0.854326758727003 5.04256669663285e-07 -1.01838808023932 3.26776270502471e-10 MirTarget -0.331028787727269 4.09019841310736e-13 NA NA NA hsa-miR-148a-3p CYTH3 -0.748702855596996 3.93313343865641e-07 0.609753795487233 1.49167558303658e-06 MirTarget;miRNATAP -0.287885455378431 1.71620007242084e-12 NA NA NA hsa-miR-20a-5p DAB2 0.854326758727003 5.04256669663285e-07 -0.0812678108323723 0.659390389044208 MirTarget;miRNATAP -0.149841610964144 0.00403571251642021 NA NA NA hsa-miR-20a-5p DAZAP2 0.854326758727003 5.04256669663285e-07 -0.394188137321676 2.84409057316998e-10 MirTarget;miRNATAP -0.11332417819355 1.16334033949638e-10 NA NA NA hsa-miR-27b-3p DBF4B -0.823491817819754 9.20935302746823e-14 1.55009756540313 1.30826586160845e-27 MirTarget -0.278647490530304 1.88561296441866e-05 NA NA NA hsa-miR-20a-5p DCUN1D3 0.854326758727003 5.04256669663285e-07 -1.24556558748867 1.01261431238042e-35 MirTarget -0.160550668144602 1.34972646858528e-07 NA NA NA hsa-miR-192-5p DDHD1 -0.50188499512787 0.00344713341196035 0.275816408841005 0.021963997897021 miRNAWalker2_validate -0.127991076982228 0.00016546494069896 NA NA NA hsa-miR-192-5p DEAF1 -0.50188499512787 0.00344713341196035 0.730388231552352 6.33628408362944e-15 miRNAWalker2_validate -0.116881065661527 1.74444308703138e-05 NA NA NA hsa-miR-192-5p DEGS1 -0.50188499512787 0.00344713341196035 0.402759746150533 4.33549672472546e-05 miRNAWalker2_validate -0.130817180464935 2.58661311896181e-06 NA NA NA hsa-miR-27b-3p DEPDC1B -0.823491817819754 9.20935302746823e-14 2.81995289547286 3.64152756583752e-21 MirTarget -0.602856302949885 7.24923243948977e-06 NA NA NA hsa-miR-27b-3p DGCR14 -0.823491817819754 9.20935302746823e-14 0.507649776620343 1.75813829818611e-11 mirMAP -0.129981330854806 8.2165049316989e-05 NA NA NA hsa-miR-20a-5p DGKE 0.854326758727003 5.04256669663285e-07 -0.855065779351597 4.0361991167554e-06 MirTarget -0.234462315968758 8.71988897326527e-06 NA NA NA hsa-miR-20a-5p DIP2C 0.854326758727003 5.04256669663285e-07 -0.777858675870751 4.97084735087691e-05 miRNATAP -0.251988168401984 3.45920914574403e-06 NA NA NA hsa-miR-20a-5p DIRC2 0.854326758727003 5.04256669663285e-07 -0.0583843779576894 0.490426282360048 MirTarget;miRNATAP -0.217969462965237 7.28336614394969e-22 NA NA NA hsa-miR-20a-5p DIXDC1 0.854326758727003 5.04256669663285e-07 -1.03337855682211 1.80344543578202e-10 mirMAP -0.281889296972183 9.60235865890741e-10 NA NA NA hsa-miR-20a-5p DLC1 0.854326758727003 5.04256669663285e-07 -1.42279739514993 6.69575982669214e-23 miRNAWalker2_validate;miRNATAP -0.177390403581051 3.6245603031967e-05 NA NA NA hsa-miR-20a-5p DLG2 0.854326758727003 5.04256669663285e-07 -1.94736926226419 3.34813832074824e-14 mirMAP -0.365285100773836 9.13655135441683e-07 NA NA NA hsa-miR-192-5p DLG5 -0.50188499512787 0.00344713341196035 1.50511854034316 3.93408903539969e-21 miRNAWalker2_validate -0.159449173907036 0.000775276233348482 NA NA NA hsa-miR-192-5p DLGAP5 -0.50188499512787 0.00344713341196035 4.10741783900744 2.38289419329605e-47 miRNAWalker2_validate -0.202888895855437 0.0254710736562676 NA NA NA hsa-miR-27b-3p DLL4 -0.823491817819754 9.20935302746823e-14 1.07379585219093 2.85322047024912e-15 miRNATAP -0.153412966174776 0.011415697218425 NA NA NA hsa-miR-20a-5p DMD 0.854326758727003 5.04256669663285e-07 -1.6618166260325 2.70344741582688e-17 mirMAP -0.275398809271483 1.6121705940957e-06 NA NA NA hsa-miR-148a-3p DMPK -0.748702855596996 3.93313343865641e-07 0.656614767219979 1.80881732624839e-07 MirTarget -0.30785961316669 2.61560071271051e-14 NA NA NA hsa-miR-27b-3p DMXL2 -0.823491817819754 9.20935302746823e-14 0.350388524150803 0.00209064181253301 miRNATAP -0.122751476742272 0.0125750712949817 NA NA NA hsa-miR-192-5p DNAJB5 -0.50188499512787 0.00344713341196035 0.366457775682137 0.000167813461757478 miRNAWalker2_validate -0.164090642735937 1.69105367324604e-09 NA NA NA hsa-miR-20a-5p DNAJB9 0.854326758727003 5.04256669663285e-07 -0.631181264981697 8.66249196538849e-07 miRNATAP -0.20096568172869 2.96222695664608e-08 NA NA NA hsa-miR-148a-3p DNAJC18 -0.748702855596996 3.93313343865641e-07 0.379578184862879 0.00785785435417525 MirTarget -0.482256465265997 2.60755726904746e-28 NA NA NA hsa-miR-20a-5p DNAJC27 0.854326758727003 5.04256669663285e-07 -0.350802101061359 0.000255703839327469 MirTarget;miRNATAP -0.140515052548109 1.83689397879291e-07 NA NA NA hsa-miR-27b-3p DNAJC5B -0.823491817819754 9.20935302746823e-14 -0.393343492416372 0.121626961014019 miRNATAP -0.220345017711243 0.0445644618528854 NA NA NA hsa-miR-192-5p DNAL1 -0.50188499512787 0.00344713341196035 -0.0875635311142695 0.300992092038673 miRNAWalker2_validate -0.198548317578036 4.84586710712504e-18 NA NA NA hsa-miR-148a-3p DNER -0.748702855596996 3.93313343865641e-07 1.29255242782277 0.00336209766653278 MirTarget;miRNATAP -1.04467659125513 1.06494193352452e-13 NA NA NA hsa-miR-148a-3p DNMT1 -0.748702855596996 3.93313343865641e-07 1.07072601011042 3.56408109602049e-16 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.222357078113257 4.38571155341952e-07 25865490;26111756;25950085;22167392 miR 148a dependent apoptosis of bladder cancer cells is mediated in part by the epigenetic modifier DNMT1; We additionally show that miR-148a exerts this effect partially by attenuating expression of DNA methyltransferase 1 DNMT1;Moreover we found that miR-148a appeared to be a target of bufalin and miR-148a further regulated DNMT1 and p27 to control the stemness of OS cells;The Interplay Between miR 148a and DNMT1 Might be Exploited for Pancreatic Cancer Therapy; We discovered the expression level of miR-148a significantly decreased in pancreatic cancer tissues whereas that of DNMT1 increased; In ASPC-1 cancer cells the overexpression of miR-148a led to a decreased level of DNMT1 and reduced the proliferation and metastasis of ASPC-1 cells; Interestingly it was shown that the DNMT1 inhibition enhanced the expression of miR-148a; In vivo studies demonstrated that the tumorigenesis of ASPC-1 was significantly arrested by either the overexpression of miR-148a or the inhibition of DNMT1;Studies have shown that microRNA-148a miR-148a was proved to be silenced while DNA methyltransferase 1 DNMT1 was over-expressed in gastric cancer; But the mechanism of aberrant expression of miR-148a and DNMT1 and their relationships in gastric cancer are still unknown; The aims of this study were to investigate the expression profile of miR-148a and DNMT1 and reveal whether they have any relationships; We used reverse-transcriptase quantitative real-time PCR methylation-specific PCR and Western blot to measure the level of miR-148a expression DNA methylation level and DNMT1 expression respectively; DNMT1 was over-expressed in primary tumors and cell lines while knockdown of DNMT1 using siRNA could decrease methylation level of miR-148a promoter and restore its expression; Furthermore ectopic over-expression of miR-148a in cancer cell lines caused reduction in DNMT1 expression and inhibited cell proliferation but no obvious change was found in apoptosis rate; These results suggest that miR-148a is inactivated by DNA hypermethylation of promoter region in gastric cancer which is mediated through DNMT1 over-expression; Additionally the silence of miR-148a reduces its suppression to DNMT1 in gastric cancer and this may in turn result in over-expression of DNMT1 and promote DNA hypermethylation ;;metastasis;tumorigenesis; bladder cancer;sarcoma;pancreatic cancer;gastric cancer hsa-miR-148a-3p DNMT3B -0.748702855596996 3.93313343865641e-07 1.61793226634891 7.24162651287187e-19 miRNAWalker2_validate;miRTarBase -0.192692774033865 0.00195212252979673 20841507 Low ERG expressers presented with down-regulation of genes involved in the DNA-methylation machinery and up-regulation of miR-148a which targets DNMT3B acute myeloid leukemia hsa-miR-148a-3p DOCK3 -0.748702855596996 3.93313343865641e-07 1.89917396490138 8.65073654235979e-17 miRNATAP -0.283819265304344 0.000239484898895635 NA NA NA hsa-miR-20a-5p DOCK4 0.854326758727003 5.04256669663285e-07 -0.196572963974556 0.0730533705216442 MirTarget -0.136682179554845 8.95116115068355e-06 NA NA NA hsa-miR-148a-3p DOCK6 -0.748702855596996 3.93313343865641e-07 0.921029085267333 4.1395349862803e-24 MirTarget -0.242316323155687 1.46606073675809e-15 NA NA NA hsa-miR-192-5p DOK6 -0.50188499512787 0.00344713341196035 -1.91134260561967 2.47519280623105e-09 mirMAP -0.307832195941665 0.000873173634559653 NA NA NA hsa-miR-148a-3p DOT1L -0.748702855596996 3.93313343865641e-07 0.585703387018246 2.71031330751421e-07 mirMAP -0.105927324502338 0.00490233486966271 NA NA NA hsa-miR-148a-3p DPP3 -0.748702855596996 3.93313343865641e-07 0.367930824003208 7.7340018984217e-06 miRNATAP -0.13173717479097 8.52306013192258e-07 NA NA NA hsa-miR-20a-5p DPYSL2 0.854326758727003 5.04256669663285e-07 -0.459626007194783 0.000892653964210093 MirTarget;miRNATAP -0.330848399343528 1.93357247682817e-18 NA NA NA hsa-miR-148a-3p DSTYK -0.748702855596996 3.93313343865641e-07 1.00504202460505 2.41375496861128e-19 miRNAWalker2_validate -0.200328046355734 1.06054134520476e-07 NA NA NA hsa-miR-192-5p DSTYK -0.50188499512787 0.00344713341196035 1.00504202460505 2.41375496861128e-19 miRNAWalker2_validate -0.26635143039323 6.98100480748641e-17 NA NA NA hsa-miR-148a-3p DTNA -0.748702855596996 3.93313343865641e-07 1.85440917822318 1.2434230849807e-10 miRNATAP -0.419016677215032 1.19731795266872e-05 NA NA NA hsa-miR-27b-3p DTNA -0.823491817819754 9.20935302746823e-14 1.85440917822318 1.2434230849807e-10 MirTarget;miRNATAP -0.297124202192461 0.0195354631628679 NA NA NA hsa-miR-27b-3p DVL2 -0.823491817819754 9.20935302746823e-14 0.932937814675565 4.78146420278758e-20 miRNATAP -0.221394297021235 1.09073127725023e-06 NA NA NA hsa-miR-20a-5p DYNC1LI2 0.854326758727003 5.04256669663285e-07 -0.0593819216914442 0.412674243061 MirTarget;miRNATAP -0.121628876378183 1.2491959709815e-09 NA NA NA hsa-miR-27b-3p DYNC2LI1 -0.823491817819754 9.20935302746823e-14 0.33945373719519 5.25531155032593e-05 MirTarget -0.122980208954955 0.000681994547554579 NA NA NA hsa-miR-148a-3p DYRK1B -0.748702855596996 3.93313343865641e-07 0.432980103635144 0.000665367161987308 miRNATAP -0.226263129684861 3.85397710195182e-08 NA NA NA hsa-miR-192-5p DYRK3 -0.50188499512787 0.00344713341196035 -0.123384598809894 0.439896233886906 MirTarget;miRNATAP -0.29301169186636 3.46788053219141e-11 NA NA NA hsa-miR-148a-3p E2F3 -0.748702855596996 3.93313343865641e-07 0.679179223655044 3.98775697474768e-07 miRNATAP -0.286439887340466 4.00406934916546e-11 NA NA NA hsa-miR-192-5p E2F5 -0.50188499512787 0.00344713341196035 0.730554652437087 0.000401890915871585 miRNAWalker2_validate -0.165569976807069 0.00489423335560786 NA NA NA hsa-miR-27b-3p E2F6 -0.823491817819754 9.20935302746823e-14 0.329712583456323 5.20721454340624e-05 miRNATAP -0.109439121091417 0.00186337699356186 NA NA NA hsa-miR-148a-3p E2F7 -0.748702855596996 3.93313343865641e-07 3.06815276582178 3.19808997821633e-30 miRNATAP -0.243822828282522 0.00994914998543976 NA NA NA hsa-miR-27b-3p E2F7 -0.823491817819754 9.20935302746823e-14 3.06815276582178 3.19808997821633e-30 miRNATAP -0.554743182226216 7.34719457907851e-06 NA NA NA hsa-miR-192-5p ECT2 -0.50188499512787 0.00344713341196035 2.35414440886737 1.90301512891325e-30 miRNAWalker2_validate -0.231432070728605 0.000212033641687837 NA NA NA hsa-miR-20a-5p EDA2R 0.854326758727003 5.04256669663285e-07 0.557823623183193 0.0666300815964547 MirTarget -0.349896313309194 4.49449080159799e-05 NA NA NA hsa-miR-20a-5p EDEM1 0.854326758727003 5.04256669663285e-07 -0.854125196107966 8.48935244483275e-15 mirMAP -0.16890991285102 1.07819115404201e-07 NA NA NA hsa-miR-192-5p EEF1A2 -0.50188499512787 0.00344713341196035 3.15424331884889 1.24880876453237e-06 miRNAWalker2_validate -0.442810056416726 0.0179285880904937 NA NA NA hsa-miR-27b-3p EFNA3 -0.823491817819754 9.20935302746823e-14 1.74857523726189 1.89670377349898e-17 miRNATAP -0.583190806894562 1.14503674353614e-10 NA NA NA hsa-miR-20a-5p EFNB1 0.854326758727003 5.04256669663285e-07 -0.0364954474014203 0.756378948827121 miRNATAP -0.13113223545145 7.23593446328842e-05 NA NA NA hsa-miR-148a-3p EFNB2 -0.748702855596996 3.93313343865641e-07 0.0997333215214327 0.477026029683948 MirTarget;miRNATAP -0.186304808477715 4.15657096208185e-05 NA NA NA hsa-miR-192-5p EFNB2 -0.50188499512787 0.00344713341196035 0.0997333215214327 0.477026029683948 miRNAWalker2_validate;miRNATAP -0.167969783572693 2.02210945072605e-05 NA NA NA hsa-miR-192-5p EFR3B -0.50188499512787 0.00344713341196035 0.419893657122922 0.00614160314164536 mirMAP -0.267653467596125 3.69126874444107e-10 NA NA NA hsa-miR-146a-5p EGFR -0.742958238440575 0.000765983177482633 -1.01672920195188 6.69873186671412e-07 miRNAWalker2_validate -0.224421920698198 6.22524592924969e-07 24895573;25242818;22161865;25596948;25417703;23555954;24839931;21632853 Furthermore western blot showed that miR-146a mimic downregulated EGFR ERK1/2 and stat5 signalings; These effects were less potent compared to that of a siRNA targeting EGFR a known target gene of miR-146a; Moreover miR-146a mimic could enhance the cell growth inhibition and apoptosis induction impact of various EGFR targeting agents;Interestingly re-expression of miR-146a inhibited the invasive capacity of Colo357 and Panc-1 PC cells with concomitant down-regulation of EGFR and IRAK-1; Most importantly we found that the treatment of PC cells with "natural agents" 33'-diinodolylmethane DIM or isoflavone led to an increase in the expression of miR-146a and consequently down-regulated the expression of EGFR MTA-2 IRAK-1 and NF-κB resulting in the inhibition of invasion of Colo357 and Panc-1 cells;MiR 146a suppresses tumor growth and progression by targeting EGFR pathway and in a p ERK dependent manner in castration resistant prostate cancer; Mechanistic studies revealed that miR-146a repressed the expression of EGFR through binding to its 3'-untranslated region; Our findings suggest that ubiquitous loss of miR-146a is a critical mechanism for overexpression of EGFR in CRPC which is crucial to better understanding the pathogenesis of CRPC;Furthermore the expressions of bax and cleaved-caspase-3 mainly were increased in control and overexpression miR-146a groups however the expression of EGFR was inverse; All the results demonstrated that quercetin exhibited excellent effect on inhibiting cell proliferation in human breast cancer cells which was performed by up-regulating miR-146a expression then via inducing apoptosis through caspase-3 activation and mitochondrial-dependent pathways and inhibiting invasion through down-regulating the expression of EGFR;Here we report a previously unrecognized posttranscriptional mechanism by which BRCA1 regulates EGFR expression through the induction of miR-146a; We show that BRCA1 binds to MIR146A promoter and activates transcription which in turn attenuates EGFR expression;In functional experiments miR-146a suppressed cell growth induced cellular apoptosis and inhibited EGFR downstream signaling in five NSCLC cell lines H358 H1650 H1975 HCC827 and H292 miR-146a also inhibited the migratory capacity of these NSCLC cells; On the other hand miR-146a enhanced the inhibition of cell proliferation by drugs targeting EGFR including both TKIs gefitinib erlotinib and afatinib and a monoclonal antibody cetuximab; Our results suggest that these effects of miR-146a are due to its targeting of EGFR and NF-κB signaling;Deregulation of miR 146a expression in a mouse model of pancreatic cancer affecting EGFR signaling; Treatment of PC cells with CDF a novel synthetic compound led to re-expression of miR-146a resulting in the down-regulation of EGFR expression; Further knock-down of miR-146a in AsPC-1 cells led to the up-regulation of EGFR expression and showed increased clonogenic growth; In addition knock-down of EGFR by EGFR siRNA transfection of parental AsPC-1 cells and AsPC-1 cells stably transfected with pre-miR-146a resulted in decreased invasive capacity which was further confirmed by reduced luciferase activity in cells transfected with pMIR-Luc reporter vector containing miR-146a binding site; Collectively these results suggest that the loss of expression of miR-146a is a fundamental mechanism for over-expression of EGFR signaling and that re-expression of miR-146a by CDF treatment could be useful in designing personalized strategy for the treatment of human PC;The regulation of EGFR and IRAK1 by miR-146a was examined with miR-146a-transfected gastric cancer cells; Ectopic expression of miR-146a inhibited migration and invasion and downregulated EGFR and IRAK1 expression in gastric cancer cells; MiR-146a targeting of EGFR and IRAK1 is an independent prognostic factor in gastric cancer cases ;;progression;;;;; liver cancer;pancreatic cancer;prostate cancer;breast cancer;breast cancer;lung squamous cell cancer;pancreatic cancer;gastric cancer hsa-miR-146b-5p EGFR 0.419719546795449 0.0457375823220155 -1.01672920195188 6.69873186671412e-07 miRNATAP -0.221138858293073 3.44879306513365e-06 NA NA NA hsa-miR-148b-5p EGFR 0.295777213389605 0.0255749859535438 -1.01672920195188 6.69873186671412e-07 mirMAP -0.233539600600063 0.00227279523782391 NA NA NA hsa-miR-155-5p EGFR 0.0108524225071784 0.95651331033505 -1.01672920195188 6.69873186671412e-07 miRNAWalker2_validate;MirTarget -0.128466970088693 0.0115801509528144 NA NA NA hsa-miR-17-5p EGFR 0.698861147045461 2.43854106455398e-05 -1.01672920195188 6.69873186671412e-07 TargetScan -0.161590563481239 0.00764134099999989 NA NA NA hsa-miR-188-5p EGFR 1.11646899351496 9.56686958408598e-11 -1.01672920195188 6.69873186671412e-07 mirMAP -0.300235014857475 1.22424681244032e-07 NA NA NA hsa-miR-21-5p EGFR 1.51084295924322 1.54551622173259e-34 -1.01672920195188 6.69873186671412e-07 miRNAWalker2_validate;miRTarBase -0.440371363258275 3.21604130567409e-09 24198203;20113523;24012640;24331411;26563758;19597153;26026961;20048743 In radically resected NSCLC patients the expression levels of miR-21 10b in patients with EGFR mutation were much higher than those without mutation;Thus the miR-21 inhibitor might interrupt the activity of EGFR pathways independently of PTEN status;Further the expression of miR-21 is regulated by EGFR via the activation of β-catenin and AP-1; These data indicate that a feedback loop exists between miR-21 and EGFR; These results clarify a novel association between miR-21 and EGFR in the regulation of cancer cell progression;MiR 21 overexpression is associated with acquired resistance of EGFR TKI in non small cell lung cancer;Higher expression levels of miR-21 AmiR-27a and miR-218 detected in this study suggest potential roles of these miRNAs in primary resistance to EGFR-TKI in advanced NSCLC patients with EGFR exon 19 deletion mutations;MiR 21 is an EGFR regulated anti apoptotic factor in lung cancer in never smokers; The changes in expression of some of these miRNAs including miR-21 were more remarkable in cases with EGFR mutations than in those without these mutations; In the never-smoker-derived lung adenocarcinoma cell line H3255 with mutant EGFR and high levels of p-EGFR and miR-21 antisense inhibition of miR-21 enhanced AG1478-induced apoptosis; In a never-smoker-derived adenocarcinoma cell line H441 with wild-type EGFR the antisense miR-21 not only showed the additive effect with AG1478 but also induced apoptosis by itself; These results suggest that aberrantly increased expression of miR-21 which is enhanced further by the activated EGFR signaling pathway plays a significant role in lung carcinogenesis in never-smokers as well as in smokers and is a potential therapeutic target in both EGFR-mutant and wild-type cases;Nickel may contribute to EGFR mutation and synergistically promotes tumor invasion in EGFR mutated lung cancer via nickel induced microRNA 21 expression;Downregulation of miR 21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status ;;progression;drug resistance;staging;drug resistance;tumorigenesis;; lung squamous cell cancer;glioblastoma;glioblastoma;lung squamous cell cancer;lung squamous cell cancer;lung cancer;lung cancer;glioblastoma hsa-miR-29a-5p EGFR -0.113555908626946 0.349622266470788 -1.01672920195188 6.69873186671412e-07 mirMAP -0.458889085026057 2.82252978142708e-08 27477273 Feedback Loop Regulation of SCAP/SREBP 1 by miR 29 Modulates EGFR Signaling Driven Glioblastoma Growth glioblastoma hsa-miR-32-3p EGFR 0.219109440121582 0.207217051619543 -1.01672920195188 6.69873186671412e-07 mirMAP -0.238124126347676 6.9947851263588e-05 NA NA NA hsa-miR-362-5p EGFR 0.717921690799312 1.68392734504524e-05 -1.01672920195188 6.69873186671412e-07 mirMAP -0.247853042376492 3.33470814837779e-05 NA NA NA hsa-miR-3682-3p EGFR 0.805600143458555 8.7874424633131e-06 -1.01672920195188 6.69873186671412e-07 mirMAP -0.12932547288846 0.0249956294814211 NA NA NA hsa-miR-374b-3p EGFR -0.137420230218985 0.305318192448799 -1.01672920195188 6.69873186671412e-07 mirMAP -0.202869152527087 0.00750806275200147 NA NA NA hsa-miR-455-5p EGFR -0.270546034117157 0.0581320703577731 -1.01672920195188 6.69873186671412e-07 miRanda -0.226922724788645 0.00135818927133814 NA NA NA hsa-miR-501-5p EGFR 1.15231083477882 2.98906150004088e-10 -1.01672920195188 6.69873186671412e-07 mirMAP -0.228828416518186 2.10663471825952e-05 NA NA NA hsa-miR-590-5p EGFR -0.103355559980404 0.310027295317092 -1.01672920195188 6.69873186671412e-07 miRanda;mirMAP -0.282971808483034 0.00478577902454241 NA NA NA hsa-miR-618 EGFR 0.13539895350352 0.517145913114103 -1.01672920195188 6.69873186671412e-07 mirMAP -0.104183567265845 0.0380128909987004 NA NA NA hsa-miR-769-5p EGFR 0.219661452072771 0.0333425465750576 -1.01672920195188 6.69873186671412e-07 mirMAP -0.501593765874938 2.76004531715872e-07 NA NA NA hsa-miR-877-5p EGFR 1.35669625926821 1.43008125755656e-11 -1.01672920195188 6.69873186671412e-07 mirMAP -0.247141034396675 1.1588258665615e-06 NA NA NA hsa-miR-15a-5p EGLN1 0.349521211668244 0.000770735998804736 0.0756107370151957 0.405502512247036 MirTarget -0.199232552642064 2.38498365947827e-06 NA NA NA hsa-miR-16-2-3p EGLN1 -0.0336420826463706 0.805158952566973 0.0756107370151957 0.405502512247036 mirMAP -0.154448651591541 1.62881459061765e-06 NA NA NA hsa-miR-16-5p EGLN1 -0.398577235179603 0.000101598495180191 0.0756107370151957 0.405502512247036 MirTarget -0.184906710341522 1.5638193085266e-05 NA NA NA hsa-miR-17-5p EGLN1 0.698861147045461 2.43854106455398e-05 0.0756107370151957 0.405502512247036 TargetScan -0.102696431475396 9.47932370331605e-05 NA NA NA hsa-miR-186-5p EGLN1 -0.060103391373687 0.535288717081205 0.0756107370151957 0.405502512247036 mirMAP -0.139054765598172 0.00251459263459613 NA NA NA hsa-miR-1976 EGLN1 -0.431472440543166 0.00324575010550946 0.0756107370151957 0.405502512247036 MirTarget -0.117052103230428 9.15621715743439e-05 NA NA NA hsa-miR-590-3p EGLN1 -0.473167498047808 1.76652934637227e-05 0.0756107370151957 0.405502512247036 miRanda;mirMAP -0.116534466317335 0.0035050444625743 NA NA NA hsa-miR-590-5p EGLN1 -0.103355559980404 0.310027295317092 0.0756107370151957 0.405502512247036 miRanda -0.196266966880368 6.27078388640176e-06 NA NA NA hsa-miR-20a-5p EGR2 0.854326758727003 5.04256669663285e-07 -2.92720452155501 5.23330307324282e-27 MirTarget;miRNATAP -0.392517470696261 1.49319772446471e-06 23924943 Involvement of miR 20a in promoting gastric cancer progression by targeting early growth response 2 EGR2; Luciferase activity and Western blot confirmed that miR-20a negatively regulated EGR2 expression; Overexpression of EGR2 significantly attenuated the oncogenic effect of miR-20a miR-20a was involved in the carcinogenesis of GC through modulation of the EGR2 signaling pathway progression;drug resistance;tumorigenesis gastric cancer hsa-miR-148a-3p EGR3 -0.748702855596996 3.93313343865641e-07 -2.49025618015861 9.70314095894188e-25 MirTarget -0.209189146874948 0.0129875229995118 NA NA NA hsa-miR-192-5p EHBP1L1 -0.50188499512787 0.00344713341196035 0.331486249355696 0.00123833313803043 miRNAWalker2_validate -0.149522454377421 2.10263925524772e-07 NA NA NA hsa-miR-27b-3p EHMT2 -0.823491817819754 9.20935302746823e-14 1.30916131333971 6.434117976644e-33 miRNAWalker2_validate -0.244496105915327 1.35799566097197e-06 NA NA NA hsa-miR-27b-3p EIF2AK2 -0.823491817819754 9.20935302746823e-14 -0.0743296928421406 0.469391726504632 mirMAP -0.151761569808996 0.000556375195833077 NA NA NA hsa-miR-27b-3p EIF2S2 -0.823491817819754 9.20935302746823e-14 0.317957817884656 2.49059742366842e-05 miRNATAP -0.115910394349106 0.00036114562038191 NA NA NA hsa-miR-148a-3p ELFN2 -0.748702855596996 3.93313343865641e-07 2.86706730299717 2.25493376503085e-09 mirMAP -0.483208813462652 0.00248298597422395 NA NA NA hsa-miR-20a-5p ELK3 0.854326758727003 5.04256669663285e-07 -0.374593711821051 0.0677288387929772 MirTarget;miRNATAP -0.260010389374476 6.49942666577106e-06 NA NA NA hsa-miR-20a-5p ELK4 0.854326758727003 5.04256669663285e-07 0.23519596686873 0.0267189511596387 miRNATAP -0.130494503212055 1.21344676733769e-05 NA NA NA hsa-miR-192-5p ELOVL1 -0.50188499512787 0.00344713341196035 0.772132123121458 7.40013744177412e-22 miRNAWalker2_validate -0.130972869698946 2.74902140074231e-08 NA NA NA hsa-miR-192-5p EMB -0.50188499512787 0.00344713341196035 -0.51114171042416 0.0227127805618997 miRNAWalker2_validate -0.465964670702723 4.98075890858267e-14 NA NA NA hsa-miR-192-5p EML1 -0.50188499512787 0.00344713341196035 -0.62886462630818 0.000194859905761294 miRNAWalker2_validate -0.225326163106881 2.33447679051203e-06 NA NA NA hsa-miR-27b-3p EN2 -0.823491817819754 9.20935302746823e-14 0.979515878391363 0.00653397638746686 MirTarget;miRNATAP -0.386228831891449 0.0131678915762146 NA NA NA hsa-miR-27b-3p ENAH -0.823491817819754 9.20935302746823e-14 1.39629433723863 3.42757488063496e-20 miRNATAP -0.376842331240528 2.44055180499439e-08 NA NA NA hsa-miR-192-5p ENC1 -0.50188499512787 0.00344713341196035 -1.087792569799 1.5617178371754e-09 miRNAWalker2_validate -0.165619390590527 0.00144767299135608 NA NA NA hsa-miR-192-5p ENDOD1 -0.50188499512787 0.00344713341196035 -0.998600185815336 9.70620010845927e-08 miRNAWalker2_validate -0.463066599557689 2.93930391048484e-19 NA NA NA hsa-miR-148a-3p ENTPD1 -0.748702855596996 3.93313343865641e-07 0.548264152440102 1.02295823309827e-09 mirMAP -0.300291742240826 8.25145845724624e-27 NA NA NA hsa-miR-192-5p ENTPD3 -0.50188499512787 0.00344713341196035 0.296163404386955 0.380560088941134 miRNAWalker2_validate -0.515033294773545 4.8899737507346e-08 NA NA NA hsa-miR-20a-5p EPAS1 0.854326758727003 5.04256669663285e-07 -0.884989955981347 7.97509276269862e-17 miRNATAP -0.132064017426939 2.07565893687308e-05 NA NA NA hsa-miR-148a-3p EPB41L1 -0.748702855596996 3.93313343865641e-07 0.134154503301847 0.605658196491617 MirTarget -0.302843609687242 0.000339392792749624 NA NA NA hsa-miR-192-5p EPDR1 -0.50188499512787 0.00344713341196035 0.218631967122443 0.25962335180911 miRNAWalker2_validate -0.255870434514823 2.60146198251815e-06 NA NA NA hsa-miR-20a-5p EPHA4 0.854326758727003 5.04256669663285e-07 -0.0136675398232678 0.946218625851897 miRNATAP -0.211339657032399 0.000213656396565315 NA NA NA hsa-miR-148a-3p EPN2 -0.748702855596996 3.93313343865641e-07 0.0353361937087526 0.693340512927564 MirTarget;miRNATAP -0.116478658095663 5.79350548452928e-05 NA NA NA hsa-miR-20a-5p ERAP1 0.854326758727003 5.04256669663285e-07 -0.0558751979920373 0.664128805537484 MirTarget -0.159909130653423 9.33581675488412e-06 NA NA NA hsa-miR-148a-3p ERC2 -0.748702855596996 3.93313343865641e-07 1.31841593023186 2.0512747793649e-05 MirTarget -0.310718760201474 0.00231511105017742 NA NA NA hsa-miR-192-5p ERCC6L -0.50188499512787 0.00344713341196035 2.80133333720022 1.52716959352411e-34 miRNAWalker2_validate -0.143546239673975 0.0423567403392569 NA NA NA hsa-miR-148a-3p ERMP1 -0.748702855596996 3.93313343865641e-07 0.542622265078398 5.31729874404597e-06 MirTarget -0.255518323160464 3.01191040047704e-11 NA NA NA hsa-miR-192-5p ERMP1 -0.50188499512787 0.00344713341196035 0.542622265078398 5.31729874404597e-06 miRNAWalker2_validate -0.122926009117854 0.00029724995055624 NA NA NA hsa-miR-20a-5p ESYT2 0.854326758727003 5.04256669663285e-07 -0.172147082999767 0.039027418424603 mirMAP -0.141888770769474 8.4393527551558e-10 NA NA NA hsa-miR-10b-3p ETS1 2.77189254628215 2.26687582932628e-20 -0.888146453921594 7.30600721510989e-10 mirMAP -0.105519293114893 1.58415058877614e-05 NA NA NA hsa-miR-1180-3p ETS1 1.13535217859875 1.17286173228245e-09 -0.888146453921594 7.30600721510989e-10 MirTarget -0.293265031973102 8.05459469251981e-16 NA NA NA hsa-miR-130b-5p ETS1 0.170599813152408 0.337611586432771 -0.888146453921594 7.30600721510989e-10 MirTarget -0.117830624648738 0.00350746127707538 NA NA NA hsa-miR-148b-5p ETS1 0.295777213389605 0.0255749859535438 -0.888146453921594 7.30600721510989e-10 MirTarget -0.14433424168597 0.00795478698949807 NA NA NA hsa-miR-16-1-3p ETS1 0.392360028038559 0.00112481918108198 -0.888146453921594 7.30600721510989e-10 MirTarget -0.14163124063757 0.0176332220270728 NA NA NA hsa-miR-186-5p ETS1 -0.060103391373687 0.535288717081205 -0.888146453921594 7.30600721510989e-10 mirMAP -0.15329403808341 0.0411464992332332 NA NA NA hsa-miR-193a-3p ETS1 -0.117675551589896 0.309391958208578 -0.888146453921594 7.30600721510989e-10 miRanda;miRNATAP -0.206450097116881 0.000921512501112203 NA NA NA hsa-miR-221-3p ETS1 1.12244756358612 3.48370308238012e-13 -0.888146453921594 7.30600721510989e-10 miRTarBase;miRNATAP -0.163620716574743 0.000282330030340872 21711453 To close the loop we demonstrate ETS-1 as a direct target of miR-222 but not miR-221 showing the novel option of their uncoupled functions melanoma hsa-miR-222-3p ETS1 1.08574156066353 1.76407192348131e-11 -0.888146453921594 7.30600721510989e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.114027687122358 0.00860678284178252 21711453 Constitutive activation of the ETS 1 miR 222 circuitry in metastatic melanoma; We demonstrate that the proto-oncogene ETS-1 involved in the pathogenesis of cancers of different origin is a transcriptional regulator of miR-222 by direct binding to its promoter region; Differently from 293FT cells or early stage melanomas where unphosphorylated ETS-1 represses miR-222 transcription in metastatic melanoma the constitutively Thr-38 phosphorylated fraction of ETS-1 induces miR-222; To close the loop we demonstrate ETS-1 as a direct target of miR-222 but not miR-221 showing the novel option of their uncoupled functions staging melanoma hsa-miR-30d-3p ETS1 -0.120562286038759 0.329549534782125 -0.888146453921594 7.30600721510989e-10 mirMAP -0.123711965263521 0.0344163749253352 NA NA NA hsa-miR-362-3p ETS1 0.814007335895913 2.00108618836568e-09 -0.888146453921594 7.30600721510989e-10 miRanda -0.181573270953595 0.000463194817826299 NA NA NA hsa-miR-365a-3p ETS1 0.164591326307714 0.15325084963213 -0.888146453921594 7.30600721510989e-10 MirTarget -0.267990900609134 1.68132949421869e-05 NA NA NA hsa-miR-421 ETS1 0.941856334694081 6.12167297054077e-08 -0.888146453921594 7.30600721510989e-10 miRanda;mirMAP;miRNATAP -0.204100092132273 4.23645182774089e-07 NA NA NA hsa-miR-455-5p ETS1 -0.270546034117157 0.0581320703577731 -0.888146453921594 7.30600721510989e-10 MirTarget;PITA;miRanda;miRNATAP -0.234313961624189 2.69025876931775e-06 NA NA NA hsa-miR-501-5p ETS1 1.15231083477882 2.98906150004088e-10 -0.888146453921594 7.30600721510989e-10 mirMAP -0.10302951257088 0.00734880104767461 NA NA NA hsa-miR-502-5p ETS1 0.892373335336396 1.7122694518919e-06 -0.888146453921594 7.30600721510989e-10 miRNATAP -0.110285767636931 0.00447567568456658 NA NA NA hsa-miR-532-3p ETS1 0.297601533259956 0.014632205884815 -0.888146453921594 7.30600721510989e-10 MirTarget;PITA;miRNATAP -0.287398076993315 8.8786296594351e-07 NA NA NA hsa-miR-590-5p ETS1 -0.103355559980404 0.310027295317092 -0.888146453921594 7.30600721510989e-10 miRanda -0.359124442253989 3.41545113201445e-07 NA NA NA hsa-miR-660-5p ETS1 0.989755850734071 5.69930767464937e-14 -0.888146453921594 7.30600721510989e-10 MirTarget -0.254076650434129 1.2827423637958e-06 NA NA NA hsa-miR-769-5p ETS1 0.219661452072771 0.0333425465750576 -0.888146453921594 7.30600721510989e-10 miRNATAP -0.213050530713541 0.00233319206600267 NA NA NA hsa-miR-940 ETS1 0.453020092551484 0.0177054921651997 -0.888146453921594 7.30600721510989e-10 MirTarget;miRNATAP -0.152992991185501 6.8236118996806e-05 NA NA NA hsa-miR-20a-5p ETV1 0.854326758727003 5.04256669663285e-07 -0.467778656758692 0.0521717741982034 MirTarget;miRNATAP -0.240188015746806 0.000419927774962963 NA NA NA hsa-miR-148a-3p ETV5 -0.748702855596996 3.93313343865641e-07 -0.145389102256725 0.355370993767523 MirTarget;miRNATAP -0.296784259819511 4.1170913506311e-09 NA NA NA hsa-miR-148a-3p F3 -0.748702855596996 3.93313343865641e-07 -1.77735272391257 4.53941856275069e-12 MirTarget -0.587483900043743 2.87917611994749e-12 NA NA NA hsa-miR-20a-5p F3 0.854326758727003 5.04256669663285e-07 -1.77735272391257 4.53941856275069e-12 MirTarget;miRNATAP -0.165197021230371 0.0273527859606424 NA NA NA hsa-miR-192-5p FAIM -0.50188499512787 0.00344713341196035 0.589207851373054 1.02493249390092e-06 miRNAWalker2_validate -0.179088764169198 1.55634241957254e-07 NA NA NA hsa-miR-27b-3p FAM104A -0.823491817819754 9.20935302746823e-14 0.382548867340036 2.14628142056169e-09 miRNATAP -0.158596180848725 7.31027875965331e-09 NA NA NA hsa-miR-20a-5p FAM129B 0.854326758727003 5.04256669663285e-07 -0.133693429940162 0.416336428141766 miRNATAP -0.151836023746115 0.00107229987436081 NA NA NA hsa-miR-148a-3p FAM160B2 -0.748702855596996 3.93313343865641e-07 0.170041130884332 0.0540544370833985 mirMAP -0.161281958630114 1.22626225985271e-08 NA NA NA hsa-miR-192-5p FAM171B -0.50188499512787 0.00344713341196035 0.778198641601071 0.000133185104883409 miRNAWalker2_validate -0.490320367180017 1.52905309018984e-18 NA NA NA hsa-miR-192-5p FAM189A2 -0.50188499512787 0.00344713341196035 -0.0450400191974518 0.824442625113164 miRNAWalker2_validate -0.414168948858265 1.21955548739979e-13 NA NA NA hsa-miR-192-5p FAM26E -0.50188499512787 0.00344713341196035 -0.107372888081332 0.496336542380078 mirMAP -0.304381445099328 2.8178877804066e-12 NA NA NA hsa-miR-20a-5p FAM46C 0.854326758727003 5.04256669663285e-07 -1.65510942063513 7.80605621031549e-14 MirTarget;miRNATAP -0.23687630172238 0.000240559026938884 NA NA NA hsa-miR-148a-3p FAM53B -0.748702855596996 3.93313343865641e-07 0.971989850032648 4.87327424473216e-17 mirMAP -0.286212044971369 6.7551492819291e-14 NA NA NA hsa-miR-192-5p FAM63B -0.50188499512787 0.00344713341196035 -0.544563365894281 0.0024060920267518 miRNAWalker2_validate -0.105779153820658 0.0385950551807212 NA NA NA hsa-miR-192-5p FAM78A -0.50188499512787 0.00344713341196035 0.0903525081525882 0.529997378795919 mirMAP -0.289851963096595 2.44007378015315e-13 NA NA NA hsa-miR-27b-3p FAM78A -0.823491817819754 9.20935302746823e-14 0.0903525081525882 0.529997378795919 MirTarget;miRNATAP -0.225735536898208 0.000248369174004847 NA NA NA hsa-miR-27b-3p FAM98A -0.823491817819754 9.20935302746823e-14 0.0180974020493805 0.783041392639418 miRNATAP -0.102008237447877 0.000262123037598327 NA NA NA hsa-miR-192-5p FANCI -0.50188499512787 0.00344713341196035 2.58883645204084 1.64497704333454e-42 miRNAWalker2_validate -0.176796714534105 0.00303346372639052 NA NA NA hsa-miR-20a-5p FAT4 0.854326758727003 5.04256669663285e-07 -1.89155225461558 9.6858796116854e-13 MirTarget;miRNATAP -0.496036601832729 5.58352564019072e-11 NA NA NA hsa-miR-192-5p FBN1 -0.50188499512787 0.00344713341196035 0.042762327488989 0.844747911420757 miRNAWalker2_validate -0.450531498850048 6.18310358582424e-14 NA NA NA hsa-miR-148a-3p FBXL19 -0.748702855596996 3.93313343865641e-07 1.09129763767905 3.05430880690495e-25 miRNATAP -0.383651844314371 1.41544005302887e-29 NA NA NA hsa-miR-20a-5p FBXL5 0.854326758727003 5.04256669663285e-07 -0.357457961344926 0.000593569927680263 miRNATAP -0.207724562110672 5.42148505974551e-13 NA NA NA hsa-miR-20a-5p FBXO28 0.854326758727003 5.04256669663285e-07 -0.503712735174914 1.26784281427187e-10 MirTarget;miRNATAP -0.12845013161489 7.68431904164944e-09 NA NA NA hsa-miR-20a-5p FBXO3 0.854326758727003 5.04256669663285e-07 -0.544237692707206 2.24798669719614e-09 miRNAWalker2_validate;mirMAP -0.131693301098245 3.74930518188946e-07 25115392 F box protein FBXO31 is down regulated in gastric cancer and negatively regulated by miR 17 and miR 20a; miR-20a and miR-17 directly bind to the 3'-UTR of FBXO31; Moreover a highly significant negative correlation between miR-20a miR-17 and FBXO31 was observed in these GC samples gastric cancer hsa-miR-20a-5p FBXO31 0.854326758727003 5.04256669663285e-07 -0.0963682529727059 0.572770500648494 MirTarget -0.168739569512217 0.000460471078682578 25115392 F box protein FBXO31 is down regulated in gastric cancer and negatively regulated by miR 17 and miR 20a; miR-20a and miR-17 directly bind to the 3'-UTR of FBXO31; Moreover a highly significant negative correlation between miR-20a miR-17 and FBXO31 was observed in these GC samples gastric cancer hsa-miR-27b-3p FBXO32 -0.823491817819754 9.20935302746823e-14 1.49973264070402 1.35888111194844e-11 miRNATAP -0.516688019767081 9.38353902752944e-08 NA NA NA hsa-miR-20a-5p FEM1C 0.854326758727003 5.04256669663285e-07 -0.503681375330292 2.07828929078027e-07 MirTarget;miRNATAP -0.101327781636578 0.000253456735866326 NA NA NA hsa-miR-192-5p FERMT1 -0.50188499512787 0.00344713341196035 1.14528954642755 0.00602104982484306 miRNAWalker2_validate -0.516729220766827 1.146972710071e-05 NA NA NA hsa-miR-20a-5p FGD4 0.854326758727003 5.04256669663285e-07 -1.15544171645474 1.45947973849956e-12 MirTarget -0.339502877510144 2.09715099852461e-13 NA NA NA hsa-miR-20a-5p FGD5 0.854326758727003 5.04256669663285e-07 -0.0869101677163209 0.581625732970603 MirTarget;miRNATAP -0.120006135249983 0.00711832346596723 NA NA NA hsa-miR-103a-3p FGF2 0.765568928457606 3.05497476509383e-12 -1.08625533231299 0.000324809942833161 miRNAWalker2_validate;MirTarget;miRNATAP -0.333696884446656 0.0118326533065286 NA NA NA hsa-miR-15b-3p FGF2 0.238105490431193 0.0997721500357416 -1.08625533231299 0.000324809942833161 mirMAP -0.499213807743807 9.41955107470528e-07 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-5p FGF2 0.230566941413564 0.0824765001857479 -1.08625533231299 0.000324809942833161 MirTarget;miRNATAP -0.306809751282981 0.00622064491645458 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-2-3p FGF2 -0.0336420826463706 0.805158952566973 -1.08625533231299 0.000324809942833161 mirMAP -0.422467965590387 0.000103679884556575 NA NA NA hsa-miR-181a-5p FGF2 0.250113435902954 0.0551933249319293 -1.08625533231299 0.000324809942833161 mirMAP -0.406045352280239 0.000358497143826792 NA NA NA hsa-miR-181b-5p FGF2 0.488256489401108 0.00105321129419701 -1.08625533231299 0.000324809942833161 mirMAP -0.523910277677257 9.1015168945214e-08 NA NA NA hsa-miR-19b-1-5p FGF2 -0.277804782598538 0.0783067794722916 -1.08625533231299 0.000324809942833161 mirMAP -0.529151998934904 1.16181517704286e-08 NA NA NA hsa-miR-200b-3p FGF2 -1.29335788099229 0.000268623234305059 -1.08625533231299 0.000324809942833161 mirMAP -0.168899172593471 4.11351056555817e-05 NA NA NA hsa-miR-200c-3p FGF2 -0.104675615392797 0.716957669484981 -1.08625533231299 0.000324809942833161 mirMAP -0.156084549253076 0.00233819769179705 NA NA NA hsa-miR-20a-3p FGF2 -0.318177901603857 0.0467885456739855 -1.08625533231299 0.000324809942833161 mirMAP -0.492065243098747 8.09310422865092e-08 NA NA NA hsa-miR-21-3p FGF2 -0.484219378716006 0.00299941098417659 -1.08625533231299 0.000324809942833161 mirMAP -0.240197113439825 0.00811114129230132 NA NA NA hsa-miR-21-5p FGF2 1.51084295924322 1.54551622173259e-34 -1.08625533231299 0.000324809942833161 mirMAP -0.443381765546842 5.91228766084995e-05 NA NA NA hsa-miR-215-5p FGF2 -0.981544773246509 3.14452272477156e-05 -1.08625533231299 0.000324809942833161 miRNAWalker2_validate -0.153448795618752 0.0138240489461602 NA NA NA hsa-miR-217 FGF2 1.05797297540381 0.0401026692682422 -1.08625533231299 0.000324809942833161 miRanda -0.127490520581258 7.38698652450206e-06 NA NA NA hsa-miR-222-3p FGF2 1.08574156066353 1.76407192348131e-11 -1.08625533231299 0.000324809942833161 mirMAP -0.206975558906397 0.0212088626227192 NA NA NA hsa-miR-330-3p FGF2 -0.332364259424489 0.0316051913061459 -1.08625533231299 0.000324809942833161 mirMAP -0.238733647850468 0.0151404054794887 NA NA NA hsa-miR-335-3p FGF2 -0.275199247483111 0.106629165248783 -1.08625533231299 0.000324809942833161 mirMAP -0.405107692314837 2.67658505476485e-06 NA NA NA hsa-miR-338-5p FGF2 -0.221898432884726 0.252390988727086 -1.08625533231299 0.000324809942833161 mirMAP -0.277477917380717 0.000298421894309671 NA NA NA hsa-miR-429 FGF2 -1.40262535827285 6.93982219171912e-05 -1.08625533231299 0.000324809942833161 mirMAP -0.192074793475977 4.45604159403906e-06 NA NA NA hsa-miR-452-5p FGF2 1.91544498799508 1.81995982853313e-14 -1.08625533231299 0.000324809942833161 mirMAP -0.254292038125162 7.84361502048493e-06 NA NA NA hsa-miR-589-3p FGF2 1.16846704028095 5.88525574424201e-11 -1.08625533231299 0.000324809942833161 mirMAP -0.346323302130209 2.68946343007257e-05 NA NA NA hsa-miR-590-5p FGF2 -0.103355559980404 0.310027295317092 -1.08625533231299 0.000324809942833161 miRanda;mirMAP -0.300649640419796 0.0415702477858108 NA NA NA hsa-miR-92a-3p FGF2 0.212391012518195 0.134292268089997 -1.08625533231299 0.000324809942833161 miRNAWalker2_validate -0.635934402042256 6.72536311164143e-10 NA NA NA hsa-miR-93-3p FGF2 0.402821129107592 0.00131324842735588 -1.08625533231299 0.000324809942833161 mirMAP -0.437085459323848 0.000209985380897254 NA NA NA hsa-miR-20a-5p FGF7 0.854326758727003 5.04256669663285e-07 -0.653895802717462 0.00602323864930533 miRNAWalker2_validate -0.341470101333498 3.32475785382172e-07 NA NA NA hsa-miR-20a-5p FGFR1 0.854326758727003 5.04256669663285e-07 -1.10351511026112 4.12675064572266e-07 mirMAP -0.287282538249605 3.68706352846777e-06 NA NA NA hsa-miR-100-5p FGFR3 -0.783576782126614 0.000219958772262677 0.189024805500786 0.340204942325551 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.269596147351536 1.27205852375091e-09 25344675;26604796;26018508;23778527 MicroRNA 100 regulates pancreatic cancer cells growth and sensitivity to chemotherapy through targeting FGFR3; The predicted target of miR-100 fibroblast growth factor receptor 3 FGFR3 was downregulated by siRNA to examine its effect on pancreatic cancer cells; Luciferase essay showed FGFR3 was direct target of miR-100; FGFR3 was significantly downregulated by overexpressing miR-100 in pancreatic cancer cells and knocking down FGFR3 by siRNA exerted similar effect as miR-100; Our study demonstrated that miR-100 played an important role in pancreatic cancer development possibly through targeting FGFR3;Overexpression of miR 100 inhibits cell proliferation migration and chemosensitivity in human glioblastoma through FGFR3; Expression of fibroblast growth factor receptor 3 FGFR3 the bioinformatically predicted target of miR-100 was examined by Western blot in glioblastoma; FGFR3 was directly regulated by miR-100 in glioblastoma; Ectopically overexpressing FGFR3 was able to ameliorate the anticancer effects of upregulation of miR-100 on glioblastoma growth migration and chemosensitivity; Overexpressing miR-100 had anticancer effects on glioblastoma likely through regulation of FGFR3;Overexpression of miR 100 inhibits growth of osteosarcoma through FGFR3; Here we reported significantly higher levels of fibroblast growth factor receptor 3 FGFR3 and significantly lower levels of miR-100 in the OS specimen compared to those in the paired normal bone tissues; Bioinformatics analysis and luciferase reporter assay suggest that miR-100 binds to the 3'UTR of FGFR3 mRNA to prevent its translation; Taken together our data demonstrate that miR-100 may inhibit the growth of OS through FGFR3;Hypoxia regulates FGFR3 expression via HIF 1α and miR 100 and contributes to cell survival in non muscle invasive bladder cancer; We have previously investigated the role of microRNAs in bladder cancer and have shown that FGFR3 is a target of miR-100; In this study we investigated the effects of hypoxia on miR-100 and FGFR3 expression and the link between miR-100 and FGFR3 in hypoxia; Bladder cancer cell lines were exposed to normoxic or hypoxic conditions and examined for the expression of FGFR3 by quantitative PCR qPCR and western blotting and miR-100 by qPCR; The effect of FGFR3 and miR-100 on cell viability in two-dimensional 2-D and three-dimensional 3-D was examined by transfecting siRNA or mimic-100 respectively; Increased FGFR3 was also in part dependent on miR-100 levels which decreased in hypoxia; Hypoxia in part via suppression of miR-100 induces FGFR3 expression in bladder cancer both of which have an important role in maintaining cell viability under conditions of stress ;;;poor survival pancreatic cancer;glioblastoma;sarcoma;bladder cancer hsa-miR-590-3p FGFR3 -0.473167498047808 1.76652934637227e-05 0.189024805500786 0.340204942325551 miRanda -0.178376084373127 0.0416868756939642 NA NA NA hsa-miR-99a-5p FGFR3 -1.51481656384839 3.93230057259529e-14 0.189024805500786 0.340204942325551 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.302096873169716 3.68370160731018e-11 23409016;24456664;23298836 Photofrin based photodynamic therapy and miR 99a transfection inhibited FGFR3 and PI3K/Akt signaling mechanisms to control growth of human glioblastoma In vitro and in vivo; Further photofrin based PDT followed by miR-99a transfection dramatically increased miR-99a expression and also increased apoptosis in glioblastoma cell cultures and drastically reduced tumor growth in athymic nude mice due to down regulation of fibroblast growth factor receptor 3 FGFR3 and PI3K/Akt signaling mechanisms leading to inhibition of cell proliferation and induction of molecular mechanisms of apoptosis;miR 99a promotes proliferation targeting FGFR3 in human epithelial ovarian cancer cells; Importantly fibroblast growth factor receptor 3 FGFR3 predicted to be one target gene of miR-99a using computational algorithms was higher in expression in EOC cells; Subsequently FGFR3 was proved to be direct target of miR-99a by dual luciferase assay; Furthermore overexpression of miR-99a dramatically suppressed expression level of FGFR3 at both mRNA and protein levels proving FGFR3 to be inversely correlated with miR-99a; Finally overexpression of miR-99a could significantly inhibit EOC cell proliferation in vitro by decreasing the expression of FGFR3 which also reduced the EOC cell growth after siRNA knockdown; Conclusively miR-99a expression was remarkably downregulated in serums tissues and cell and suppresses EOC cell proliferation by targeting FGFR3 suggesting miR-99a as a prospective prognosis marker and potential tumor suppressor for EOC therapeutics;The tumorigenic FGFR3 TACC3 gene fusion escapes miR 99a regulation in glioblastoma; The fusion caused by tandem duplication on 4p16.3 led to the loss of the 3'-UTR of FGFR3 blocking gene regulation of miR-99a and enhancing expression of the fusion gene ;worse prognosis; glioblastoma;ovarian cancer;glioblastoma hsa-miR-20a-5p FGL2 0.854326758727003 5.04256669663285e-07 -1.57400116275033 9.67186609155287e-17 MirTarget -0.296408617212126 7.39384140087011e-08 NA NA NA hsa-miR-192-5p FHDC1 -0.50188499512787 0.00344713341196035 1.32319998637117 1.26356481591792e-07 miRNAWalker2_validate;MirTarget -0.438392625074586 5.7916971813987e-10 NA NA NA hsa-miR-20a-5p FHL2 0.854326758727003 5.04256669663285e-07 -1.48982772048475 2.74414125249484e-09 mirMAP -0.569805616964817 3.57503576277774e-16 NA NA NA hsa-miR-20a-5p FIBIN 0.854326758727003 5.04256669663285e-07 -1.08654865070202 0.00125372317323056 MirTarget -0.380954691513929 6.51644464790147e-05 NA NA NA hsa-miR-20a-5p FJX1 0.854326758727003 5.04256669663285e-07 -0.0578285980687501 0.721991012392702 MirTarget;miRNATAP -0.158121392126183 0.000558689914263595 NA NA NA hsa-miR-20a-5p FKBP5 0.854326758727003 5.04256669663285e-07 -0.232073250029758 0.19420333201796 mirMAP -0.229419740768159 4.84211785897638e-06 NA NA NA hsa-miR-192-5p FLI1 -0.50188499512787 0.00344713341196035 -0.394821639499866 0.00277147867169758 MirTarget -0.230615224508645 3.6514514909311e-10 NA NA NA hsa-miR-20a-5p FLNA 0.854326758727003 5.04256669663285e-07 0.227340527470956 0.203430797039815 miRNAWalker2_validate -0.238395501979443 1.97781492413483e-06 NA NA NA hsa-miR-148a-3p FLOT2 -0.748702855596996 3.93313343865641e-07 0.174241659619787 0.0839095721996099 MirTarget -0.135661337188965 3.25812696544883e-05 NA NA NA hsa-miR-20a-5p FLT1 0.854326758727003 5.04256669663285e-07 0.348253937407654 0.00775687550206773 MirTarget;miRNATAP -0.123502068793973 0.000848936793187574 NA NA NA hsa-miR-20a-5p FMN1 0.854326758727003 5.04256669663285e-07 -0.641575890494061 0.0277147350428254 mirMAP -0.399544884856271 1.06761398743688e-06 NA NA NA hsa-miR-148a-3p FMNL3 -0.748702855596996 3.93313343865641e-07 0.665131482558671 1.67762417764945e-07 miRNATAP -0.454255007976079 2.93997652908655e-31 NA NA NA hsa-miR-20a-5p FNDC3A 0.854326758727003 5.04256669663285e-07 -0.995884475839302 2.03718393267477e-13 MirTarget;miRNATAP -0.163778149537746 3.08732263491971e-05 NA NA NA hsa-miR-20a-5p FNIP2 0.854326758727003 5.04256669663285e-07 -1.97277564777211 1.79187762303784e-13 MirTarget -0.233422413182353 0.0028341350099152 NA NA NA hsa-miR-148a-3p FOXF1 -0.748702855596996 3.93313343865641e-07 -1.93657438569129 8.48580930399672e-18 MirTarget -0.314860376896413 3.72189697847819e-05 NA NA NA hsa-miR-20a-5p FOXJ2 0.854326758727003 5.04256669663285e-07 0.0215239532173994 0.812716242710092 MirTarget;miRNATAP -0.107015818950805 2.59631251490628e-05 NA NA NA hsa-miR-148a-3p FOXK1 -0.748702855596996 3.93313343865641e-07 1.204250755958 4.1435634806038e-25 mirMAP -0.278355247713312 1.45950739758757e-12 NA NA NA hsa-miR-27b-3p FOXK1 -0.823491817819754 9.20935302746823e-14 1.204250755958 4.1435634806038e-25 mirMAP -0.211784357880967 6.26620134274736e-05 NA NA NA hsa-miR-148a-3p FOXK2 -0.748702855596996 3.93313343865641e-07 0.559422556682597 5.5934596281655e-10 miRNATAP -0.122231023757654 4.16509173410562e-05 NA NA NA hsa-miR-92a-1-5p FOXP2 0.389443191151075 0.0644925359204601 -3.24994941369723 1.71142859920958e-14 MirTarget -0.200263854344854 0.0492279385999498 NA NA NA hsa-miR-20a-5p FRMD6 0.854326758727003 5.04256669663285e-07 -1.21152640864769 5.47511255884304e-11 MirTarget;miRNATAP -0.279756250197403 1.25931771546973e-07 NA NA NA hsa-miR-20a-5p FTO 0.854326758727003 5.04256669663285e-07 -0.232812028117052 0.00922973083936813 mirMAP -0.167029963182185 1.43329087776647e-11 NA NA NA hsa-miR-92a-1-5p FTO 0.389443191151075 0.0644925359204601 -0.232812028117052 0.00922973083936813 mirMAP -0.100017243697381 1.07364162523646e-06 NA NA NA hsa-miR-192-5p FUT11 -0.50188499512787 0.00344713341196035 -0.315279657472101 0.0136223466695405 miRNAWalker2_validate -0.127162726232481 0.000433381025657782 NA NA NA hsa-miR-20a-5p FYCO1 0.854326758727003 5.04256669663285e-07 -0.0148324387984431 0.883365385401447 MirTarget -0.187319599335118 1.83690964964603e-11 NA NA NA hsa-miR-20a-5p FYN 0.854326758727003 5.04256669663285e-07 -1.05543942235431 1.10191754676925e-15 miRNATAP -0.231854719621814 1.0029459490739e-09 NA NA NA hsa-miR-192-5p FZD1 -0.50188499512787 0.00344713341196035 -0.990655512447529 2.10933438723933e-07 miRNAWalker2_validate -0.45834591686859 3.50571643482894e-18 NA NA NA hsa-miR-20a-5p FZD3 0.854326758727003 5.04256669663285e-07 -0.431602727356764 0.0760494397449049 MirTarget;mirMAP;miRNATAP -0.263395197675831 0.000124585706310954 NA NA NA hsa-miR-20a-5p FZD4 0.854326758727003 5.04256669663285e-07 -0.346477770504521 0.0109747315056824 miRNATAP -0.232364507622619 9.13182947842467e-10 NA NA NA hsa-miR-101-3p FZD6 -1.48176407980989 3.98950707385704e-31 0.589500198001939 0.00374127878510925 miRNAWalker2_validate;MirTarget -0.312670748498135 1.38907823475328e-05 NA NA NA hsa-miR-139-5p FZD6 -2.11299531796557 8.16407076415038e-28 0.589500198001939 0.00374127878510925 miRanda -0.171390807110702 0.00034847427750895 NA NA NA hsa-miR-194-5p FZD6 -0.292530160992458 0.0996141384876663 0.589500198001939 0.00374127878510925 MirTarget -0.265420163621645 1.75074747054336e-06 NA NA NA hsa-miR-455-5p FZD6 -0.270546034117157 0.0581320703577731 0.589500198001939 0.00374127878510925 miRanda -0.230555626016252 0.000940179578305785 NA NA NA hsa-miR-192-5p FZD7 -0.50188499512787 0.00344713341196035 -0.284533887049024 0.256557978536031 miRNAWalker2_validate -0.59446912784293 2.96084223842181e-18 NA NA NA hsa-miR-192-5p FZD9 -0.50188499512787 0.00344713341196035 -0.243785341556497 0.505341223526538 miRNATAP -0.306354280194544 0.00309846297489247 NA NA NA hsa-miR-192-5p GALNT12 -0.50188499512787 0.00344713341196035 -0.63804508821255 0.043770525430056 miRNAWalker2_validate -0.393099848798327 1.04134877468359e-05 NA NA NA hsa-miR-27b-3p GALNT7 -0.823491817819754 9.20935302746823e-14 -0.27652761191448 0.222052571963854 MirTarget;miRNATAP -0.405362308033425 2.87854634577228e-05 NA NA NA hsa-miR-148a-3p GAS1 -0.748702855596996 3.93313343865641e-07 -2.01123836877249 1.00269358999977e-12 miRNAWalker2_validate -0.446935540677881 1.98427341642504e-06 NA NA NA hsa-miR-20a-5p GATA6 0.854326758727003 5.04256669663285e-07 -1.09329244365753 9.73202176150752e-11 miRNAWalker2_validate -0.182406476921655 0.0001839014146683 NA NA NA hsa-miR-20a-5p GBP4 0.854326758727003 5.04256669663285e-07 -0.650160615796805 0.000187737985372556 mirMAP -0.278560661052495 1.21269341759649e-08 NA NA NA hsa-miR-20a-5p GCA 0.854326758727003 5.04256669663285e-07 -0.56871649988492 0.000267567519146868 MirTarget -0.137354807188299 0.00197386476031777 NA NA NA hsa-miR-20a-5p GCLM 0.854326758727003 5.04256669663285e-07 -0.490472345051649 0.00239558983173471 mirMAP -0.142887688343017 0.00182984460395035 NA NA NA hsa-miR-20a-5p GCNT4 0.854326758727003 5.04256669663285e-07 -0.356605715930898 0.144778964659476 MirTarget -0.306926373858422 8.02814582313197e-06 NA NA NA hsa-miR-148a-3p GDF6 -0.748702855596996 3.93313343865641e-07 -2.10139054692363 1.01669881798518e-11 miRNATAP -0.327974606729441 0.00151705432220982 NA NA NA hsa-miR-192-5p GDPD5 -0.50188499512787 0.00344713341196035 0.0440112951343092 0.780082492291835 mirMAP -0.237511551530035 6.771421543163e-08 NA NA NA hsa-miR-20a-5p GFRA1 0.854326758727003 5.04256669663285e-07 -2.5486406119615 2.43457108723549e-08 mirMAP -0.422901475150633 0.00129882390540228 NA NA NA hsa-miR-148a-3p GLIPR2 -0.748702855596996 3.93313343865641e-07 -0.261246364993241 0.126523092005897 MirTarget -0.572861369908527 5.79843097207256e-28 NA NA NA hsa-miR-20a-5p GLIS3 0.854326758727003 5.04256669663285e-07 -0.851275924384664 0.000690675817272366 miRNATAP -0.214941628315687 0.00260441279292911 NA NA NA hsa-miR-20a-5p GMPR 0.854326758727003 5.04256669663285e-07 -1.37298834189273 5.25559220935139e-06 miRNATAP -0.539895461182833 1.80876695530484e-10 NA NA NA hsa-miR-20a-5p GNA11 0.854326758727003 5.04256669663285e-07 -0.43119317908096 0.0174252610152971 mirMAP -0.123588186907321 0.0164045494778984 NA NA NA hsa-miR-27b-3p GNAZ -0.823491817819754 9.20935302746823e-14 2.76868512062906 9.54719404168263e-18 miRNATAP -0.643004767308374 7.91738782998592e-06 NA NA NA hsa-miR-27b-3p GNB1L -0.823491817819754 9.20935302746823e-14 0.972387895486426 1.58066300637692e-14 mirMAP -0.179444012670643 0.0014106931612724 NA NA NA hsa-miR-20a-5p GNE 0.854326758727003 5.04256669663285e-07 -1.82350791069008 3.50187061744317e-25 mirMAP -0.281912030681587 6.94970927305595e-08 NA NA NA hsa-miR-192-5p GNRH1 -0.50188499512787 0.00344713341196035 0.981716836590702 6.04257350059458e-10 miRNAWalker2_validate -0.270554653117322 2.01527772341779e-09 NA NA NA hsa-miR-27b-3p GNS -0.823491817819754 9.20935302746823e-14 0.326695508721711 3.76363852828077e-05 miRNATAP -0.216252562474521 1.1919492170072e-10 NA NA NA hsa-miR-27b-3p GOLM1 -0.823491817819754 9.20935302746823e-14 0.88777317418583 0.000185604842755544 MirTarget -0.593984386818351 4.66600227466396e-09 25115396 GOLM1 was directly regulated by miR-27b in PCa cells prostate cancer hsa-miR-192-5p GPC4 -0.50188499512787 0.00344713341196035 -0.913560136947943 0.0100287848448375 miRNAWalker2_validate -0.741597382018906 3.63224773665996e-14 NA NA NA hsa-miR-27b-3p GPD2 -0.823491817819754 9.20935302746823e-14 0.404567318088859 0.000374344403235026 miRNATAP -0.204896504221934 2.7707300006123e-05 NA NA NA hsa-miR-20a-5p GPR137B 0.854326758727003 5.04256669663285e-07 -0.63566282030445 0.00116530639793394 miRNATAP -0.218862401168965 7.87350981745217e-05 NA NA NA hsa-miR-192-5p GPR19 -0.50188499512787 0.00344713341196035 2.26877210340845 1.58451791616503e-23 miRNAWalker2_validate -0.167328803784092 0.01410253416713 NA NA NA hsa-miR-92a-1-5p GPR37L1 0.389443191151075 0.0644925359204601 0.777887971529071 0.00185277139347063 MirTarget -0.124529135737633 0.0326790741064306 NA NA NA hsa-miR-148a-3p GPRC5A -0.748702855596996 3.93313343865641e-07 -1.98790398617405 1.71576224263651e-08 MirTarget -0.64837950530788 2.02612216438666e-08 NA NA NA hsa-miR-20a-5p GPRC5A 0.854326758727003 5.04256669663285e-07 -1.98790398617405 1.71576224263651e-08 mirMAP -0.635015167621578 1.88323700836398e-10 NA NA NA hsa-miR-92a-1-5p GPRC5A 0.389443191151075 0.0644925359204601 -1.98790398617405 1.71576224263651e-08 MirTarget -0.190665502647815 0.0221290847827717 NA NA NA hsa-miR-20a-5p GPRIN2 0.854326758727003 5.04256669663285e-07 -3.25654701349871 4.8807952090335e-15 mirMAP -0.434581475120863 0.00035356600732262 NA NA NA hsa-miR-192-5p GPSM2 -0.50188499512787 0.00344713341196035 1.45389191030237 4.5650425831655e-20 miRNAWalker2_validate -0.118432887357732 0.0119720676753909 NA NA NA hsa-miR-20a-5p GREM2 0.854326758727003 5.04256669663285e-07 -3.6542600937751 6.32290251963313e-12 mirMAP -0.474006133075032 0.00216553404000178 NA NA NA hsa-miR-20a-5p GRHL2 0.854326758727003 5.04256669663285e-07 -3.71068446276051 1.97450241761239e-19 miRNATAP -0.355380620365655 0.00360998252234944 NA NA NA hsa-miR-27b-3p GRIN2D -0.823491817819754 9.20935302746823e-14 0.461684207778553 0.0401010164532733 miRNATAP -0.33255755619224 0.000586170418079747 NA NA NA hsa-miR-27b-3p GRK6 -0.823491817819754 9.20935302746823e-14 0.817674461563003 2.00625242116401e-19 MirTarget -0.171015198355863 2.4581985012161e-05 NA NA NA hsa-miR-20a-5p GRSF1 0.854326758727003 5.04256669663285e-07 -0.308770733373591 7.74543997813125e-06 mirMAP -0.128451784311699 2.19549621556709e-11 NA NA NA hsa-miR-192-5p GSG2 -0.50188499512787 0.00344713341196035 2.50195748255043 2.70800537781259e-29 miRNAWalker2_validate -0.184595965944579 0.00650239577922525 NA NA NA hsa-miR-20a-5p GSTM3 0.854326758727003 5.04256669663285e-07 -0.312654249223946 0.273178695247407 mirMAP -0.309976845647473 0.000116105830842585 NA NA NA hsa-miR-192-5p GULP1 -0.50188499512787 0.00344713341196035 -0.40117278239696 0.328073008560451 miRNAWalker2_validate -0.677190576744881 3.15242584216331e-09 NA NA NA hsa-miR-27b-3p H2AFZ -0.823491817819754 9.20935302746823e-14 1.04060285300063 3.49847347703049e-19 miRNATAP -0.286705963252837 2.7410475707931e-08 NA NA NA hsa-miR-27b-3p HAPLN1 -0.823491817819754 9.20935302746823e-14 1.33038232891219 0.000123661512782167 MirTarget;miRNATAP -0.681140839314463 5.0234333428161e-06 NA NA NA hsa-miR-20a-5p HAS2 0.854326758727003 5.04256669663285e-07 -2.63463009380978 1.12278136651369e-12 MirTarget -0.440242041373886 4.12785612456204e-05 NA NA NA hsa-miR-148a-3p HAS3 -0.748702855596996 3.93313343865641e-07 0.499425712466684 0.000692477830824529 miRNATAP -0.169268758647117 0.000440496808434031 NA NA NA hsa-miR-192-5p HAS3 -0.50188499512787 0.00344713341196035 0.499425712466684 0.000692477830824529 miRNAWalker2_validate -0.114818402057775 0.00614909396360974 NA NA NA hsa-miR-192-5p HBEGF -0.50188499512787 0.00344713341196035 -0.836710148093972 5.03009801941881e-09 miRNAWalker2_validate -0.234100358517178 8.58266797561741e-09 NA NA NA hsa-miR-20a-5p HBP1 0.854326758727003 5.04256669663285e-07 -0.357103377571568 1.81649948774568e-05 MirTarget;miRNATAP -0.113858473192472 1.25060213333006e-06 NA NA NA hsa-miR-192-5p HCN4 -0.50188499512787 0.00344713341196035 -0.156605172711939 0.62901535993883 miRNAWalker2_validate -0.750320170158889 2.02075374764777e-17 NA NA NA hsa-miR-20a-5p HECA 0.854326758727003 5.04256669663285e-07 -0.704842603143831 7.46272240332447e-12 miRNATAP -0.137811858167133 3.22184135934466e-06 NA NA NA hsa-miR-20a-5p HEG1 0.854326758727003 5.04256669663285e-07 0.175697577625922 0.209861547402414 miRNATAP -0.132679807492237 0.000789733039034406 NA NA NA hsa-miR-20a-5p HES2 0.854326758727003 5.04256669663285e-07 1.80546502926672 2.25475279863592e-08 mirMAP -0.210635214254067 0.0238328380967858 NA NA NA hsa-miR-20a-5p HFE 0.854326758727003 5.04256669663285e-07 -0.15872348517792 0.35310321637109 mirMAP -0.133374430060925 0.00579588610970805 NA NA NA hsa-miR-107 HIF1A 0.241662461253461 0.0170788899505389 -0.366176828296648 0.0111002186054683 miRNAWalker2_validate;miRTarBase;miRanda -0.436710343430652 2.03313957855482e-10 NA NA NA hsa-miR-17-5p HIF1A 0.698861147045461 2.43854106455398e-05 -0.366176828296648 0.0111002186054683 miRTarBase;MirTarget;TargetScan -0.207486649592262 6.73419034465465e-07 NA NA NA hsa-miR-20a-5p HIF1A 0.854326758727003 5.04256669663285e-07 -0.366176828296648 0.0111002186054683 miRNAWalker2_validate;miRTarBase;MirTarget -0.245558453559623 9.83134714947215e-10 22901144 Correlation analysis showed that the key miRNAs miR-20a and miR-20b negatively correlated with the target proteins VEGF-A and HIF-1alpha breast cancer hsa-miR-33a-5p HIF1A -0.767474460958522 1.09948756118522e-05 -0.366176828296648 0.0111002186054683 miRNAWalker2_validate -0.107227499920455 0.00730487730363833 NA NA NA hsa-miR-616-5p HIF1A 0.150569904638223 0.402836556304524 -0.366176828296648 0.0111002186054683 MirTarget -0.124976106072862 0.00144238259369066 NA NA NA hsa-miR-660-5p HIF1A 0.989755850734071 5.69930767464937e-14 -0.366176828296648 0.0111002186054683 MirTarget -0.249870386379118 1.21860559731773e-06 NA NA NA hsa-miR-93-5p HIF1A 1.39518349670953 2.84167728726712e-25 -0.366176828296648 0.0111002186054683 MirTarget -0.173769064325932 0.000425501783480084 NA NA NA hsa-miR-20a-5p HIP1 0.854326758727003 5.04256669663285e-07 -0.0194429374173284 0.918692239168554 MirTarget -0.189500746866077 0.000416765539407245 NA NA NA hsa-miR-20a-5p HIPK2 0.854326758727003 5.04256669663285e-07 -0.239689841914744 0.0838927941290475 mirMAP -0.147341560656338 0.000163378093557306 NA NA NA hsa-miR-27b-3p HIST1H1C -0.823491817819754 9.20935302746823e-14 0.809397548723961 0.000555269225773258 miRNAWalker2_validate -0.216663820228268 0.0332027419682172 NA NA NA hsa-miR-20a-5p HLF 0.854326758727003 5.04256669663285e-07 -1.56359740264692 3.39928227602253e-08 MirTarget;miRNATAP -0.227940593135166 0.00521161423637292 NA NA NA hsa-miR-20a-5p HMBOX1 0.854326758727003 5.04256669663285e-07 -0.648299686508313 1.92402108459881e-07 MirTarget;miRNATAP -0.166694525166171 2.52385249865366e-06 NA NA NA hsa-miR-148a-3p HOMER1 -0.748702855596996 3.93313343865641e-07 -0.0763641412081514 0.796151529043688 MirTarget -0.666575262467855 1.35873064627191e-12 NA NA NA hsa-miR-192-5p HOXB9 -0.50188499512787 0.00344713341196035 1.2945297060988 0.000123494835110063 miRNAWalker2_validate -0.817193266733572 9.01824638916809e-19 NA NA NA hsa-miR-27b-3p HOXC6 -0.823491817819754 9.20935302746823e-14 1.6690034552265 1.06491141525181e-05 miRNATAP -0.598372323813569 0.000273458840499387 NA NA NA hsa-miR-148a-3p HOXC8 -0.748702855596996 3.93313343865641e-07 0.89168315412305 0.00741079667695049 miRNAWalker2_validate;miRNATAP -0.316760862079704 0.00368044169533115 NA NA NA hsa-miR-20a-5p HPS5 0.854326758727003 5.04256669663285e-07 -1.54497064795797 1.96024564670947e-23 MirTarget -0.225036935244128 9.70098718500335e-07 NA NA NA hsa-miR-20a-5p HPSE 0.854326758727003 5.04256669663285e-07 -0.783944920967642 0.00198576706692966 mirMAP -0.164041864971541 0.0231280062388655 NA NA NA hsa-miR-192-5p HRH1 -0.50188499512787 0.00344713341196035 0.340287230286828 0.0286188640920779 miRNAWalker2_validate -0.435253617003633 1.04272436194531e-25 NA NA NA hsa-miR-20a-5p HS3ST1 0.854326758727003 5.04256669663285e-07 -0.516344907139293 0.0110139272698008 mirMAP -0.304719335203403 8.69461800851766e-08 NA NA NA hsa-miR-27b-3p HSDL1 -0.823491817819754 9.20935302746823e-14 0.624658214600752 9.62712068001496e-10 miRNATAP -0.282093395819959 1.31895711711252e-10 NA NA NA hsa-miR-192-5p HSPA2 -0.50188499512787 0.00344713341196035 0.245419691266019 0.113504150863356 miRNAWalker2_validate -0.206197602451252 2.16593621163362e-06 NA NA NA hsa-miR-192-5p HSPB7 -0.50188499512787 0.00344713341196035 -0.81967691208713 0.00575562764675916 mirMAP -0.715298487748838 1.0148758204378e-18 NA NA NA hsa-miR-192-5p HSPBAP1 -0.50188499512787 0.00344713341196035 0.430201326699575 2.59973730413392e-06 miRNAWalker2_validate -0.141327664152351 4.32027109534327e-08 NA NA NA hsa-miR-27b-3p HYOU1 -0.823491817819754 9.20935302746823e-14 0.537023010893351 1.5998399781904e-06 MirTarget -0.106166853931173 0.0295056089900917 NA NA NA hsa-miR-27b-3p ICOS -0.823491817819754 9.20935302746823e-14 0.273488185914632 0.356367830019625 miRNATAP -0.333247361615304 0.00906260480427004 NA NA NA hsa-miR-192-5p ID1 -0.50188499512787 0.00344713341196035 -2.25178919025733 7.10820515452733e-23 miRNAWalker2_validate -0.14911812571484 0.0297833314669114 NA NA NA hsa-miR-192-5p ID4 -0.50188499512787 0.00344713341196035 -1.27298671386794 2.11782253912459e-06 miRNAWalker2_validate -0.512916510271531 9.38394493873178e-12 NA NA NA hsa-miR-192-5p IFI44L -0.50188499512787 0.00344713341196035 -1.13811753747565 2.78017749792184e-05 MirTarget -0.226011440432251 0.00360269962780545 NA NA NA hsa-miR-92a-1-5p IFIT1 0.389443191151075 0.0644925359204601 -1.07386562710308 4.4404098831408e-06 MirTarget -0.22425665715675 3.93686297682376e-05 NA NA NA hsa-miR-192-5p IFRD1 -0.50188499512787 0.00344713341196035 0.558738711971646 9.00080994709618e-08 miRNAWalker2_validate -0.10932125958836 0.000256365878437799 NA NA NA hsa-miR-148a-3p IGDCC4 -0.748702855596996 3.93313343865641e-07 1.73062068710294 1.15353341113415e-06 miRNATAP -1.10203964346989 5.8953450678023e-23 NA NA NA hsa-miR-192-5p IGDCC4 -0.50188499512787 0.00344713341196035 1.73062068710294 1.15353341113415e-06 miRNAWalker2_validate;miRNATAP -0.738565967026633 1.03875864248912e-13 NA NA NA hsa-miR-192-5p IGF1R -0.50188499512787 0.00344713341196035 -0.704819576268303 0.00353845530141102 miRNAWalker2_validate -0.5797159058919 1.53799651190084e-18 NA NA NA hsa-miR-20a-5p IGSF10 0.854326758727003 5.04256669663285e-07 -2.2164252355052 2.87605968192535e-13 MirTarget -0.493427501413456 1.62841933417548e-08 NA NA NA hsa-miR-125a-5p IKBKG -0.91219969372382 1.38256246489548e-07 0.660366120199928 1.71867865546723e-06 miRanda -0.219029418282295 9.51829321882113e-09 NA NA NA hsa-miR-143-3p IKBKG -0.584123869220553 0.000907217687997436 0.660366120199928 1.71867865546723e-06 mirMAP -0.169551761758995 9.09905571393035e-06 NA NA NA hsa-miR-200a-3p IKBKG -1.49949292595657 3.18410995256133e-05 0.660366120199928 1.71867865546723e-06 mirMAP -0.100439586597671 5.62621816828972e-08 NA NA NA hsa-miR-24-3p IKBKG -0.257825594021966 0.00689742600215061 0.660366120199928 1.71867865546723e-06 mirMAP -0.287544034512102 5.8686253015948e-05 NA NA NA hsa-miR-3065-3p IKBKG -1.04244468016704 4.60743424372577e-05 0.660366120199928 1.71867865546723e-06 mirMAP -0.115721435331344 9.61381024877344e-06 NA NA NA hsa-miR-320a IKBKG 0.325285936317332 0.0221415065838824 0.660366120199928 1.71867865546723e-06 mirMAP -0.182311319218153 0.000133876392194021 NA NA NA hsa-miR-320b IKBKG 0.0919652022571331 0.607981643616945 0.660366120199928 1.71867865546723e-06 mirMAP -0.132285547849802 0.000522961413620221 NA NA NA hsa-miR-330-3p IKBKG -0.332364259424489 0.0316051913061459 0.660366120199928 1.71867865546723e-06 mirMAP -0.111083773167518 0.0137533606676294 NA NA NA hsa-miR-335-5p IKBKG -1.61347836513558 1.62757083289711e-19 0.660366120199928 1.71867865546723e-06 mirMAP -0.273399124951207 9.32430291537739e-15 NA NA NA hsa-miR-338-5p IKBKG -0.221898432884726 0.252390988727086 0.660366120199928 1.71867865546723e-06 mirMAP -0.206675822417303 2.68501101428877e-09 NA NA NA hsa-miR-376c-3p IKBKG -1.78544013329054 1.82972185127691e-10 0.660366120199928 1.71867865546723e-06 mirMAP -0.14083607992738 1.85430800686914e-09 NA NA NA hsa-miR-542-3p IKBKG -1.31351015149842 3.64642423288576e-22 0.660366120199928 1.71867865546723e-06 mirMAP -0.292142688932618 4.40119371820177e-10 NA NA NA hsa-miR-192-5p IKZF2 -0.50188499512787 0.00344713341196035 -0.832526663086801 1.47171329778731e-05 MirTarget -0.188022439724816 0.000606109764283179 NA NA NA hsa-miR-20a-5p IKZF2 0.854326758727003 5.04256669663285e-07 -0.832526663086801 1.47171329778731e-05 mirMAP;miRNATAP -0.35339409166984 5.02584205066545e-11 NA NA NA hsa-miR-148a-3p IL15 -0.748702855596996 3.93313343865641e-07 -0.299033597604689 0.133566104518099 MirTarget -0.360950562564519 1.84990625247238e-08 NA NA NA hsa-miR-192-5p IL15 -0.50188499512787 0.00344713341196035 -0.299033597604689 0.133566104518099 miRNAWalker2_validate -0.307919878200709 3.2482224824806e-08 NA NA NA hsa-miR-148a-3p IL17RD -0.748702855596996 3.93313343865641e-07 -0.125343297177237 0.609800523271957 miRNATAP -0.82706589585261 2.60537883515387e-28 NA NA NA hsa-miR-20a-5p IL17RD 0.854326758727003 5.04256669663285e-07 -0.125343297177237 0.609800523271957 miRNATAP -0.175414544830653 0.0116392994031397 NA NA NA hsa-miR-92a-1-5p ILDR2 0.389443191151075 0.0644925359204601 0.713621341761704 0.0496215693670125 MirTarget -0.275491322563866 0.00107216454735376 NA NA NA hsa-miR-20a-5p IMPAD1 0.854326758727003 5.04256669663285e-07 0.0533427265900235 0.638136857901558 mirMAP -0.150802121945985 2.00212787075724e-06 NA NA NA hsa-miR-192-5p INPP5F -0.50188499512787 0.00344713341196035 0.439943780947461 4.31972239513017e-05 miRNAWalker2_validate -0.103055734867059 0.000758763205060818 NA NA NA hsa-miR-27b-3p INPP5J -0.823491817819754 9.20935302746823e-14 1.51506447952545 5.95748863803298e-08 MirTarget;miRNATAP -0.52432642880818 1.61041876223075e-05 NA NA NA hsa-miR-27b-3p INPPL1 -0.823491817819754 9.20935302746823e-14 0.555628121445383 3.47480233047265e-10 miRNAWalker2_validate -0.152672935300165 7.7793998638279e-05 NA NA NA hsa-miR-20a-5p INSIG1 0.854326758727003 5.04256669663285e-07 -0.982451848864065 0.000118571254506076 miRNAWalker2_validate -0.197841600566252 0.00661179328132122 NA NA NA hsa-miR-148a-3p IQCE -0.748702855596996 3.93313343865641e-07 1.21246761004316 4.22270897620511e-25 mirMAP -0.303477931958815 1.30626379135067e-14 NA NA NA hsa-miR-27b-3p IQCE -0.823491817819754 9.20935302746823e-14 1.21246761004316 4.22270897620511e-25 mirMAP -0.3250397712002 6.36489964936852e-10 NA NA NA hsa-miR-192-5p IQGAP1 -0.50188499512787 0.00344713341196035 -0.355040840395703 0.0117780874619327 miRNAWalker2_validate -0.412627864720223 2.8039612101239e-28 NA NA NA hsa-miR-20a-5p IQSEC2 0.854326758727003 5.04256669663285e-07 -0.48464253606929 0.00305618147119171 miRNATAP -0.214829748320562 3.15454494462766e-06 NA NA NA hsa-miR-20a-5p IRF1 0.854326758727003 5.04256669663285e-07 -0.472051826973738 0.000392981425099119 MirTarget;miRNATAP -0.145650844922923 0.000113175393896431 NA NA NA hsa-miR-20a-5p IRF2 0.854326758727003 5.04256669663285e-07 -0.488730264470989 9.63225888653794e-08 miRTarBase -0.136935477498102 1.30952208570594e-07 NA NA NA hsa-miR-20a-5p ITFG1 0.854326758727003 5.04256669663285e-07 -0.564982310127911 9.74861515129265e-07 MirTarget -0.232001532273386 5.5697974058041e-13 NA NA NA hsa-miR-27b-3p ITGA2 -0.823491817819754 9.20935302746823e-14 1.53120134028147 5.03620431516659e-09 miRNATAP -0.648959489127879 1.00730961424074e-08 NA NA NA hsa-miR-148a-3p ITGA5 -0.748702855596996 3.93313343865641e-07 0.471634888877482 5.29697754708897e-05 miRNATAP -0.307894492928595 8.35158872292536e-17 NA NA NA hsa-miR-27b-3p ITGA5 -0.823491817819754 9.20935302746823e-14 0.471634888877482 5.29697754708897e-05 miRNATAP -0.10096527373625 0.0463620780367348 NA NA NA hsa-miR-125b-2-3p ITGA6 -1.6609436107315 5.71534047969855e-18 1.33116884445099 5.73067512733422e-21 mirMAP -0.177305489469283 7.67219603417741e-07 NA NA NA hsa-miR-199a-3p ITGA6 -2.3279328685682 1.04468066198593e-17 1.33116884445099 5.73067512733422e-21 PITA -0.166829140227348 2.64008048809431e-11 NA NA NA hsa-miR-199b-3p ITGA6 -2.33226605401203 9.51887435273314e-18 1.33116884445099 5.73067512733422e-21 PITA -0.166957893782338 2.45787733398932e-11 NA NA NA hsa-miR-335-3p ITGA6 -0.275199247483111 0.106629165248783 1.33116884445099 5.73067512733422e-21 mirMAP -0.138340364120149 0.00114101751107001 NA NA NA hsa-miR-342-3p ITGA6 -0.319677314984262 0.0449813878317147 1.33116884445099 5.73067512733422e-21 miRanda -0.124580956342346 0.00625142354926915 NA NA NA hsa-miR-192-5p ITGAV -0.50188499512787 0.00344713341196035 0.42083458357731 0.00760476174317356 miRNAWalker2_validate;MirTarget -0.344370980466671 1.89013250176103e-15 NA NA NA hsa-miR-32-5p ITGAV 0.0806126674664016 0.548984992497432 0.42083458357731 0.00760476174317356 miRNAWalker2_validate;MirTarget;miRNATAP -0.274975166498264 1.42681810268729e-06 NA NA NA hsa-miR-328-3p ITGAV -0.547466865311955 6.8359574451572e-06 0.42083458357731 0.00760476174317356 MirTarget -0.132063082039302 0.0363785445433637 NA NA NA hsa-miR-33a-3p ITGAV -0.683025859637737 1.01106097756419e-05 0.42083458357731 0.00760476174317356 MirTarget -0.155984185219414 0.00158654023964867 NA NA NA hsa-miR-374a-5p ITGAV 0.016390363747302 0.869784217438621 0.42083458357731 0.00760476174317356 mirMAP -0.174068026833335 0.0257907946480254 NA NA NA hsa-miR-92a-3p ITGAV 0.212391012518195 0.134292268089997 0.42083458357731 0.00760476174317356 MirTarget;miRNATAP -0.257814482101981 1.80305424957411e-06 NA NA NA hsa-miR-192-5p ITGB1 -0.50188499512787 0.00344713341196035 0.150635638369529 0.0875061080940868 miRNAWalker2_validate -0.159167916481672 6.60024481999039e-11 NA NA NA hsa-miR-148a-3p ITGB8 -0.748702855596996 3.93313343865641e-07 -2.87006066676904 1.87352126528694e-11 miRNATAP -1.14663315826581 1.03967657771964e-16 NA NA NA hsa-miR-20a-5p ITGB8 0.854326758727003 5.04256669663285e-07 -2.87006066676904 1.87352126528694e-11 MirTarget;miRNATAP -0.630843134227604 2.80236468955331e-07 NA NA NA hsa-miR-20a-5p IYD 0.854326758727003 5.04256669663285e-07 -2.66179429977146 1.10383788101266e-13 mirMAP -0.237042121408097 0.0238526235056877 NA NA NA hsa-miR-106b-5p JAK1 0.648901865047099 8.24870862047885e-09 -0.491502741052473 2.21647945606145e-08 miRNAWalker2_validate;MirTarget -0.274241391983959 1.386588824919e-13 NA NA NA hsa-miR-128-3p JAK1 0.289735108018712 0.0114419474207889 -0.491502741052473 2.21647945606145e-08 miRNAWalker2_validate -0.109369528499963 0.00404231658945177 NA NA NA hsa-miR-17-5p JAK1 0.698861147045461 2.43854106455398e-05 -0.491502741052473 2.21647945606145e-08 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.268052325740918 3.25515675433912e-28 NA NA NA hsa-miR-20a-5p JAK1 0.854326758727003 5.04256669663285e-07 -0.491502741052473 2.21647945606145e-08 MirTarget -0.23386116447226 1.56734608485868e-22 NA NA NA hsa-miR-30d-5p JAK1 0.718283816348023 2.47422074061352e-08 -0.491502741052473 2.21647945606145e-08 MirTarget -0.145093822003298 1.12748945024431e-05 NA NA NA hsa-miR-455-5p JAK1 -0.270546034117157 0.0581320703577731 -0.491502741052473 2.21647945606145e-08 miRanda -0.167977882302863 2.26382130466332e-08 NA NA NA hsa-miR-93-5p JAK1 1.39518349670953 2.84167728726712e-25 -0.491502741052473 2.21647945606145e-08 MirTarget;miRNATAP -0.238027881672368 6.65509610107069e-16 NA NA NA hsa-miR-20a-5p JAZF1 0.854326758727003 5.04256669663285e-07 -0.00573099240982522 0.96939333269824 MirTarget;miRNATAP -0.131616971924319 0.00179191886719271 NA NA NA hsa-miR-192-5p JDP2 -0.50188499512787 0.00344713341196035 -1.36060874258205 6.48057311731977e-22 mirMAP -0.117036284044381 0.00555682048555764 NA NA NA hsa-miR-20a-5p KAT2B 0.854326758727003 5.04256669663285e-07 -0.938558773689222 1.89276182546283e-10 MirTarget -0.323298461721723 5.05244582669315e-15 NA NA NA hsa-miR-20a-5p KATNAL1 0.854326758727003 5.04256669663285e-07 -0.587180254929299 2.39212781667801e-05 MirTarget -0.223397949352903 1.10005459053819e-08 NA NA NA hsa-miR-20a-5p KBTBD8 0.854326758727003 5.04256669663285e-07 -0.535277103367331 0.00302109600455283 MirTarget -0.257962681991961 3.69449355423291e-07 NA NA NA hsa-miR-20a-5p KCND3 0.854326758727003 5.04256669663285e-07 -3.73766223806269 5.88031464564806e-19 mirMAP -0.862063091166258 1.26432104813851e-12 NA NA NA hsa-miR-20a-5p KCNE4 0.854326758727003 5.04256669663285e-07 -0.633866097690669 0.01553835552073 miRNATAP -0.377494278282656 2.84523868485696e-07 NA NA NA hsa-miR-20a-5p KCNMA1 0.854326758727003 5.04256669663285e-07 -1.61689069754613 3.52157504789145e-11 miRNATAP -0.403459579869688 7.42258018508444e-09 NA NA NA hsa-miR-192-5p KCNMB4 -0.50188499512787 0.00344713341196035 -0.565600197461349 0.00811780048545861 miRNAWalker2_validate -0.49913293058438 1.28736199385812e-17 NA NA NA hsa-miR-192-5p KCNS3 -0.50188499512787 0.00344713341196035 -0.63866106057285 0.0182642298998396 miRNAWalker2_validate -0.329965109991236 1.54493827464146e-05 NA NA NA hsa-miR-192-5p KCTD12 -0.50188499512787 0.00344713341196035 -0.70118053103332 3.33540431875856e-05 miRNAWalker2_validate -0.405918816304511 2.02681062305184e-18 NA NA NA hsa-miR-92a-1-5p KCTD13 0.389443191151075 0.0644925359204601 0.354413596179034 0.000238956303886096 MirTarget -0.10246241022603 4.16084858383606e-06 NA NA NA hsa-miR-192-5p KCTD15 -0.50188499512787 0.00344713341196035 -0.0430097733946178 0.834208685250747 miRNAWalker2_validate -0.407163964667571 6.56885888036832e-13 NA NA NA hsa-miR-148a-3p KCTD2 -0.748702855596996 3.93313343865641e-07 0.444262357803045 9.18948608129488e-08 mirMAP -0.140951745613528 2.08242607078795e-07 NA NA NA hsa-miR-192-5p KCTD7 -0.50188499512787 0.00344713341196035 1.34250062788809 1.70420639599115e-29 mirMAP -0.139496609377273 0.000109662023674193 NA NA NA hsa-miR-192-5p KDELC2 -0.50188499512787 0.00344713341196035 -0.649277022737812 4.22286599020782e-06 miRNAWalker2_validate -0.154128350722706 0.000127719138751387 NA NA NA hsa-miR-20a-5p KDELC2 0.854326758727003 5.04256669663285e-07 -0.649277022737812 4.22286599020782e-06 mirMAP -0.18696431585746 3.01622700853284e-06 NA NA NA hsa-miR-20a-5p KDSR 0.854326758727003 5.04256669663285e-07 -0.9262604928472 1.15465124411196e-28 mirMAP -0.170614440987005 4.4195348151241e-12 NA NA NA hsa-miR-148a-3p KIAA0513 -0.748702855596996 3.93313343865641e-07 0.677391070221105 4.5635483547066e-07 mirMAP -0.253703395270591 6.57401063298589e-09 NA NA NA hsa-miR-20a-5p KIAA0513 0.854326758727003 5.04256669663285e-07 0.677391070221105 4.5635483547066e-07 MirTarget;miRNATAP -0.163197776938442 2.00326487179233e-05 NA NA NA hsa-miR-20a-5p KIAA0922 0.854326758727003 5.04256669663285e-07 -0.958565281032929 8.72333409466684e-14 MirTarget -0.193109143479041 1.89920385030834e-07 NA NA NA hsa-miR-148a-3p KIAA1324L -0.748702855596996 3.93313343865641e-07 -0.50219104365772 0.0775324724611569 MirTarget;miRNATAP -0.427112379558327 3.63673905587508e-06 NA NA NA hsa-miR-148a-3p KIAA1549 -0.748702855596996 3.93313343865641e-07 0.660027387081498 0.0355851637057295 miRNAWalker2_validate -0.332119877358287 0.00120295124376642 NA NA NA hsa-miR-27b-3p KIAA1614 -0.823491817819754 9.20935302746823e-14 1.19012149096204 4.91603849396984e-08 mirMAP -0.41211964337427 1.39968825837083e-05 NA NA NA hsa-miR-148a-3p KIAA1644 -0.748702855596996 3.93313343865641e-07 -1.81284684066633 3.233194276281e-09 mirMAP -0.610055069449491 1.16426577116176e-09 NA NA NA hsa-miR-192-5p KIAA1841 -0.50188499512787 0.00344713341196035 1.62652740403476 2.37568671779387e-32 miRNAWalker2_validate -0.179183516886591 1.86277536369118e-05 NA NA NA hsa-miR-148a-3p KIF14 -0.748702855596996 3.93313343865641e-07 2.98333269436721 7.27784939820496e-37 MirTarget -0.352344124898679 2.55851993740245e-05 NA NA NA hsa-miR-192-5p KIF18A -0.50188499512787 0.00344713341196035 3.68362475076135 8.5674684516454e-42 miRNAWalker2_validate -0.219605792296084 0.0103153094385285 NA NA NA hsa-miR-192-5p KIF20A -0.50188499512787 0.00344713341196035 4.26453769688785 7.51182825648091e-50 miRNAWalker2_validate -0.238877638274429 0.00963840729740923 NA NA NA hsa-miR-148a-3p KIF21B -0.748702855596996 3.93313343865641e-07 1.1784578803772 5.28752515379585e-07 mirMAP -0.282228303711302 0.000272557559842213 NA NA NA hsa-miR-192-5p KIF21B -0.50188499512787 0.00344713341196035 1.1784578803772 5.28752515379585e-07 mirMAP -0.163458605405113 0.0155582786328581 NA NA NA hsa-miR-27b-3p KIF21B -0.823491817819754 9.20935302746823e-14 1.1784578803772 5.28752515379585e-07 miRNATAP -0.674623589337565 1.75552772532421e-11 NA NA NA hsa-miR-192-5p KIF23 -0.50188499512787 0.00344713341196035 3.38260867585201 1.68312480021973e-36 miRNAWalker2_validate -0.294660430754535 0.000382369285256339 NA NA NA hsa-miR-192-5p KIF24 -0.50188499512787 0.00344713341196035 1.6808929894047 1.02551673781485e-23 miRNAWalker2_validate -0.172032148536495 0.000597193013295968 NA NA NA hsa-miR-148a-3p KIF26B -0.748702855596996 3.93313343865641e-07 0.149322876930793 0.640083141858917 mirMAP -0.839423184214391 6.45316185740642e-17 NA NA NA hsa-miR-27b-3p KIF3A -0.823491817819754 9.20935302746823e-14 0.691331553038427 1.99469350865959e-10 miRNATAP -0.18933309631604 6.78320317519226e-05 NA NA NA hsa-miR-192-5p KIF5C -0.50188499512787 0.00344713341196035 0.269855133812925 0.290746010454243 miRNAWalker2_validate -0.302444148722263 2.60065043542956e-05 NA NA NA hsa-miR-192-5p KIRREL -0.50188499512787 0.00344713341196035 -0.920556464539881 0.00842298893942037 mirMAP -0.585518652995115 2.03826200929185e-09 NA NA NA hsa-miR-20a-5p KIT 0.854326758727003 5.04256669663285e-07 -0.36947956147857 0.0945270050690569 miRTarBase -0.225765388624807 0.000296472897214121 NA NA NA hsa-miR-148a-3p KLC2 -0.748702855596996 3.93313343865641e-07 1.16492926016379 3.19134150923749e-23 miRNATAP -0.397394995398343 2.12082762386537e-25 NA NA NA hsa-miR-20a-5p KLF11 0.854326758727003 5.04256669663285e-07 -1.24274309965741 2.39323027053722e-26 MirTarget;miRNATAP -0.111614999790648 0.00153641286067475 NA NA NA hsa-miR-148a-3p KLF4 -0.748702855596996 3.93313343865641e-07 -1.65022485340468 8.09789885316327e-13 MirTarget;miRNATAP -0.22838478886868 0.00318884817829108 NA NA NA hsa-miR-20a-5p KLF9 0.854326758727003 5.04256669663285e-07 -1.35905833834713 1.22932810880238e-12 MirTarget;miRNATAP -0.30995057380615 1.69132518578895e-08 NA NA NA hsa-miR-20a-5p KLHDC10 0.854326758727003 5.04256669663285e-07 -0.301845977708177 0.070704300321483 mirMAP -0.234470415341675 5.45674023510128e-07 NA NA NA hsa-miR-20a-5p KLHL15 0.854326758727003 5.04256669663285e-07 -1.43616317329618 4.62856180062188e-29 miRNAWalker2_validate;miRNATAP -0.178014150512801 4.18811751623471e-06 NA NA NA hsa-miR-148a-3p KLHL17 -0.748702855596996 3.93313343865641e-07 1.05691261770448 1.98597989430383e-20 MirTarget -0.16415613709474 2.35704886125403e-05 NA NA NA hsa-miR-148a-3p KLHL18 -0.748702855596996 3.93313343865641e-07 0.143407270163824 0.0265548542763812 mirMAP;miRNATAP -0.100825219689263 1.21939637109394e-06 NA NA NA hsa-miR-20a-5p KLHL2 0.854326758727003 5.04256669663285e-07 -1.16669881935719 4.68056312110186e-18 miRNATAP -0.265328254818428 8.61387267689936e-12 NA NA NA hsa-miR-20a-5p KLHL20 0.854326758727003 5.04256669663285e-07 -0.255034662137329 0.0290056608745733 MirTarget;miRNATAP -0.153322225407423 2.91009251249848e-06 NA NA NA hsa-miR-27b-3p KLHL29 -0.823491817819754 9.20935302746823e-14 0.702399434101004 0.0109280929385441 miRNATAP -0.480395842021738 5.08250476487496e-05 NA NA NA hsa-miR-148a-3p KLHL6 -0.748702855596996 3.93313343865641e-07 -0.339592374400176 0.0756406505671127 mirMAP -0.359369362340502 5.01732126782505e-09 NA NA NA hsa-miR-20a-5p KLHL8 0.854326758727003 5.04256669663285e-07 -0.860556861719106 3.7235566785704e-09 mirMAP -0.257869855292933 4.35449633462033e-10 NA NA NA hsa-miR-140-3p KRAS 0.546012239205329 4.84578261098777e-11 -0.338081744192936 0.00043842779003105 MirTarget -0.247198429138234 9.22756583574077e-06 NA NA NA hsa-miR-16-1-3p KRAS 0.392360028038559 0.00112481918108198 -0.338081744192936 0.00043842779003105 mirMAP -0.114704330599848 0.00330327136149234 NA NA NA hsa-miR-193a-3p KRAS -0.117675551589896 0.309391958208578 -0.338081744192936 0.00043842779003105 MirTarget;miRanda;miRNATAP -0.128182356310374 0.00170700856743147 NA NA NA hsa-miR-193b-3p KRAS -0.166697207281748 0.272022543069482 -0.338081744192936 0.00043842779003105 miRNAWalker2_validate;MirTarget;miRNATAP -0.120510531869791 9.78248377856047e-05 25905463 Deregulation of the MiR 193b KRAS Axis Contributes to Impaired Cell Growth in Pancreatic Cancer; Mechanistically KRAS was verified as a direct effector of miR-193b through which the AKT and ERK pathways were modulated and cell growth of PDAC cells was suppressed; Taken together our findings indicate that miR-193b-mediated deregulation of the KRAS axis is involved in pancreatic carcinogenesis and suggest that miR-193b could be a potentially effective target for PDAC therapy tumorigenesis pancreatic cancer hsa-miR-30d-3p KRAS -0.120562286038759 0.329549534782125 -0.338081744192936 0.00043842779003105 MirTarget;miRNATAP -0.132565215112955 0.000512493362671086 NA NA NA hsa-miR-532-5p KRAS 1.02729546510601 9.93318913966636e-16 -0.338081744192936 0.00043842779003105 MirTarget;PITA;miRNATAP -0.137739612561571 0.000100604507963156 NA NA NA hsa-miR-148a-3p KSR2 -0.748702855596996 3.93313343865641e-07 0.506902986173332 0.110760452022147 mirMAP -0.476743808874194 3.69345752464517e-06 NA NA NA hsa-miR-192-5p KSR2 -0.50188499512787 0.00344713341196035 0.506902986173332 0.110760452022147 mirMAP -0.33303441995803 0.000208002549007142 NA NA NA hsa-miR-146b-5p LAMA2 0.419719546795449 0.0457375823220155 -2.25093797189139 1.13318229560757e-08 miRanda -0.200973106106506 0.0311052794529279 NA NA NA hsa-miR-324-5p LAMB3 0.372933276649782 0.00592280066108904 0.205469745450436 0.402537496980396 miRanda -0.210911510332022 0.017049035981626 NA NA NA hsa-miR-192-5p LAMC3 -0.50188499512787 0.00344713341196035 -1.16336935602705 0.000136555756942437 mirMAP -0.298507199873094 0.00059027334318161 NA NA NA hsa-miR-20a-5p LAMP2 0.854326758727003 5.04256669663285e-07 -0.141489314494891 0.203338123114718 mirMAP -0.226889701888816 1.09279668507289e-13 NA NA NA hsa-miR-20a-5p LAPTM4A 0.854326758727003 5.04256669663285e-07 -0.311055806827135 9.12551693197731e-06 MirTarget;miRNATAP -0.159836195718942 8.84860927771635e-17 NA NA NA hsa-miR-27b-3p LAPTM4B -0.823491817819754 9.20935302746823e-14 1.07428089690096 5.86976228026329e-07 miRNAWalker2_validate -0.311046889368618 0.000898655529855941 NA NA NA hsa-miR-20a-5p LAT2 0.854326758727003 5.04256669663285e-07 -0.473548619847502 0.00516998708211561 mirMAP -0.16301438064001 0.000679686226255119 NA NA NA hsa-miR-20a-5p LDHB 0.854326758727003 5.04256669663285e-07 -0.47508964220614 0.00689354591337264 miRNAWalker2_validate -0.134243847858072 0.00717756019266304 NA NA NA hsa-miR-20a-5p LDLR 0.854326758727003 5.04256669663285e-07 -1.46283255505596 2.87241408741105e-21 miRNATAP -0.213073152973632 3.02998935851509e-06 NA NA NA hsa-miR-20a-5p LDLRAP1 0.854326758727003 5.04256669663285e-07 -0.353413008060407 0.000695104372865604 MirTarget;miRNATAP -0.130850616126016 8.43098861239753e-06 NA NA NA hsa-miR-20a-5p LDOC1L 0.854326758727003 5.04256669663285e-07 -0.661168203841977 0.000563897974207453 mirMAP -0.117537854203184 0.0316298828109269 NA NA NA hsa-miR-148a-3p LENG8 -0.748702855596996 3.93313343865641e-07 0.75934588482606 9.40854812638038e-12 miRNATAP -0.17903107934032 1.24127378758558e-06 NA NA NA hsa-miR-192-5p LEPROTL1 -0.50188499512787 0.00344713341196035 -0.22955247257624 0.0167550852758737 miRNAWalker2_validate -0.146250428336066 4.86021306220363e-08 NA NA NA hsa-miR-192-5p LHFP -0.50188499512787 0.00344713341196035 -0.123835706003002 0.4719215089579 miRNAWalker2_validate -0.409168721965413 2.13895611689874e-18 NA NA NA hsa-miR-20a-5p LHX6 0.854326758727003 5.04256669663285e-07 0.558194088934288 0.0143299162908477 MirTarget;miRNATAP -0.152320765043608 0.0186992156229048 NA NA NA hsa-miR-20a-5p LIF 0.854326758727003 5.04256669663285e-07 -0.722255918484923 0.0325743370034823 miRNATAP -0.249921952355473 0.00917214825956543 NA NA NA hsa-miR-20a-5p LIMA1 0.854326758727003 5.04256669663285e-07 -0.0238020816121152 0.838430946766389 MirTarget;miRNATAP -0.103290213829126 0.00169430507389475 NA NA NA hsa-miR-192-5p LIMCH1 -0.50188499512787 0.00344713341196035 -1.12216634710894 4.98886861121512e-07 miRNAWalker2_validate -0.441869246854339 1.6031039768036e-12 NA NA NA hsa-miR-192-5p LIMD2 -0.50188499512787 0.00344713341196035 -0.214037676050721 0.282021903246009 mirMAP -0.292953214544803 1.41555874438372e-07 NA NA NA hsa-miR-27b-3p LIMK1 -0.823491817819754 9.20935302746823e-14 1.07371358822101 6.47096899356271e-13 MirTarget;miRNATAP -0.482019268690296 6.45470221361992e-14 NA NA NA hsa-miR-27b-3p LIMK2 -0.823491817819754 9.20935302746823e-14 0.891712220823075 3.4499668982677e-09 miRNATAP -0.320719355848057 1.00103636289881e-06 NA NA NA hsa-miR-192-5p LIMS1 -0.50188499512787 0.00344713341196035 -0.53231394759922 0.0185999713916091 miRNAWalker2_validate;MirTarget -0.154960037196009 0.0159385177083704 NA NA NA hsa-miR-27b-3p LITAF -0.823491817819754 9.20935302746823e-14 -0.221177898256862 0.0579742828236894 MirTarget;miRNATAP -0.141356603870439 0.00484003921524013 NA NA NA hsa-miR-27b-3p LMLN -0.823491817819754 9.20935302746823e-14 -0.166069500007594 0.301560342444305 MirTarget -0.225063595203432 0.00110812462534771 NA NA NA hsa-miR-92a-1-5p LMLN 0.389443191151075 0.0644925359204601 -0.166069500007594 0.301560342444305 MirTarget -0.174215783700812 2.32247861276074e-06 NA NA NA hsa-miR-192-5p LMNB2 -0.50188499512787 0.00344713341196035 1.15533579106848 2.8635849155846e-19 miRNAWalker2_validate -0.286225570514038 1.00336825060293e-14 NA NA NA hsa-miR-148a-3p LMX1B -0.748702855596996 3.93313343865641e-07 0.364650040807185 0.351279745807035 mirMAP -0.833948271652518 2.48999705809489e-11 NA NA NA hsa-miR-20a-5p LNPEP 0.854326758727003 5.04256669663285e-07 0.0381901216213942 0.796318936192664 mirMAP -0.237736137811097 7.7153738054967e-09 NA NA NA hsa-miR-148a-3p LONRF2 -0.748702855596996 3.93313343865641e-07 -1.03606777199417 0.00951581549876641 mirMAP -0.681330104510286 1.38533515320194e-07 NA NA NA hsa-miR-27b-3p LOX -0.823491817819754 9.20935302746823e-14 1.12460456664183 4.86114109294809e-06 miRNATAP -0.30480513226165 0.0044372476136409 NA NA NA hsa-miR-192-5p LOXL2 -0.50188499512787 0.00344713341196035 1.63969538101948 3.81782645914369e-28 miRNAWalker2_validate -0.406183915121298 4.54599624471813e-21 NA NA NA hsa-miR-27b-3p LPCAT1 -0.823491817819754 9.20935302746823e-14 0.979301235361667 4.14787419947705e-08 MirTarget -0.601395945528285 1.81668876458417e-15 NA NA NA hsa-miR-20a-5p LPP 0.854326758727003 5.04256669663285e-07 -0.386324215418135 0.00226265643427216 mirMAP -0.195254600915517 3.60365794828199e-08 NA NA NA hsa-miR-148a-3p LRFN1 -0.748702855596996 3.93313343865641e-07 0.250715581306462 0.275069133493013 miRNATAP -0.511549192387535 2.7107957688765e-12 NA NA NA hsa-miR-20a-5p LRIG1 0.854326758727003 5.04256669663285e-07 -0.493686164714059 8.66910284289362e-05 MirTarget -0.13207684088835 0.000216970712207246 25960225 miR 20a mediates temozolomide resistance in glioblastoma cells via negatively regulating LRIG1 expression; Here we aimed to elucidate the relationship between miR-20a its predicted target genes leucine-rich repeats and immunoglobulin-like domains 1 LRIG1 and TMZ resistance in GBM; Real-time PCR or western blot was used to measure the levels of miR-20a and LRIG1; The interaction between miR-20a and its predicted target gene LRIG1 was confirmed by 3'-UTR dual-luciferase reporter assay; MiR-20a was highly expressed and LRIG1 lowly expressed in U251/TMZ cells; The levels of LRIG1 were inversely related to miR-20a levels; And the luciferase reporter assays showed that miR-20a directly targeted the 3'UTR of LRIG1; In addition functional knock-down of LRIG1 by gene specific siRNA reversed the effect of miR-20a inhibitor; MiR-20a mediated TMZ-resistance in glioblastoma cells through negatively regulating LRIG1 expression which suggesting that miR-20a and LRIG1 would be potential therapeutic targets for glioma therapy drug resistance glioblastoma hsa-miR-192-5p LRP8 -0.50188499512787 0.00344713341196035 0.86386782073676 0.000478944145486285 miRNAWalker2_validate -0.721581622511402 8.95123147358363e-28 NA NA NA hsa-miR-192-5p LRRC10B -0.50188499512787 0.00344713341196035 1.39185459151367 1.50898746252049e-10 MirTarget -0.218431101484903 0.000509451021313216 NA NA NA hsa-miR-20a-5p LRRC55 0.854326758727003 5.04256669663285e-07 -3.40869096246176 2.95454085746275e-31 MirTarget -0.356420989120398 6.52934963704133e-05 NA NA NA hsa-miR-148a-3p LRRC8B -0.748702855596996 3.93313343865641e-07 -0.654336651065766 0.000402530838893617 mirMAP -0.436351948687831 1.51375647413546e-13 NA NA NA hsa-miR-192-5p LRRC8C -0.50188499512787 0.00344713341196035 -0.320611805711573 0.0133620124738904 miRNAWalker2_validate -0.27353820000798 1.69534848749154e-14 NA NA NA hsa-miR-192-5p LSAMP -0.50188499512787 0.00344713341196035 -0.941773692937136 0.00579276461338465 MirTarget -0.723497447820975 1.54136158700982e-14 NA NA NA hsa-miR-20a-5p LSAMP 0.854326758727003 5.04256669663285e-07 -0.941773692937136 0.00579276461338465 miRNATAP -0.28492095285676 0.00329343734899716 NA NA NA hsa-miR-20a-5p LUZP1 0.854326758727003 5.04256669663285e-07 0.206618637628015 0.0231918761468685 mirMAP;miRNATAP -0.119012701019953 3.06591851116491e-06 NA NA NA hsa-miR-92a-1-5p LUZP2 0.389443191151075 0.0644925359204601 1.08272464345489 0.00317141578198537 MirTarget -0.271086840651623 0.00148325783308685 NA NA NA hsa-miR-27b-3p LYPD3 -0.823491817819754 9.20935302746823e-14 0.645532255745848 0.00275677959072978 MirTarget;miRNATAP -0.393416274531398 2.17533559619025e-05 NA NA NA hsa-miR-192-5p LYPD6 -0.50188499512787 0.00344713341196035 -0.725999845710353 0.0490901980483611 miRNAWalker2_validate -0.392939703752258 0.00016461291037544 NA NA NA hsa-miR-192-5p MACC1 -0.50188499512787 0.00344713341196035 -2.20994472326424 5.38353974740277e-10 mirMAP -0.658497044265371 7.06012824979267e-11 NA NA NA hsa-miR-20a-5p MACC1 0.854326758727003 5.04256669663285e-07 -2.20994472326424 5.38353974740277e-10 mirMAP -0.603382261775362 2.63903793407364e-09 NA NA NA hsa-miR-192-5p MAD2L1 -0.50188499512787 0.00344713341196035 2.12271197949055 2.5877373631959e-30 miRNAWalker2_validate -0.122583021058259 0.030751139239146 NA NA NA hsa-miR-20a-5p MAF 0.854326758727003 5.04256669663285e-07 -0.855722850331053 1.97147531780957e-13 mirMAP -0.122832704018951 0.000280653557683106 NA NA NA hsa-miR-148a-3p MAF1 -0.748702855596996 3.93313343865641e-07 0.587254598885209 1.4790557878107e-07 MirTarget;miRNATAP -0.200491523719441 3.87334746762256e-08 NA NA NA hsa-miR-148a-3p MAFG -0.748702855596996 3.93313343865641e-07 1.20304222370093 2.42633916447559e-19 MirTarget -0.167941692314853 0.000226466679423781 NA NA NA hsa-miR-20a-5p MAN1C1 0.854326758727003 5.04256669663285e-07 -2.43169678885209 2.06495307195248e-21 miRNAWalker2_validate -0.50253332736108 1.66348308508865e-11 NA NA NA hsa-miR-92a-1-5p MAN2B2 0.389443191151075 0.0644925359204601 -0.613795504611358 9.80501905614247e-10 mirMAP -0.100499346399181 1.97672121304399e-05 NA NA NA hsa-miR-20a-5p MAP1B 0.854326758727003 5.04256669663285e-07 0.751522072716614 1.33167615372873e-05 mirMAP -0.218717402491076 7.96590919224439e-06 NA NA NA hsa-miR-27b-3p MAP1B -0.823491817819754 9.20935302746823e-14 0.751522072716614 1.33167615372873e-05 miRNATAP -0.194174188305758 0.00969019656533064 NA NA NA hsa-miR-192-5p MAP1LC3B -0.50188499512787 0.00344713341196035 -0.350337274997815 0.000859321673451714 miRNAWalker2_validate -0.134510341717157 5.65402881349677e-06 NA NA NA hsa-miR-20a-5p MAP2 0.854326758727003 5.04256669663285e-07 1.05154488256307 5.66592949255683e-05 miRNATAP -0.1921213460759 0.0100504096501512 NA NA NA hsa-miR-140-3p MAP2K1 0.546012239205329 4.84578261098777e-11 -1.22814648702538 4.27448032410174e-41 PITA -0.381987666476187 3.26697824928144e-11 NA NA NA hsa-miR-34a-5p MAP2K1 1.03694231790865 5.74864019540594e-14 -1.22814648702538 4.27448032410174e-41 miRNAWalker2_validate;miRTarBase -0.229470281840033 1.32655977381036e-11 NA NA NA hsa-miR-361-5p MAP2K1 0.233202959858696 0.00961572812255327 -1.22814648702538 4.27448032410174e-41 miRanda -0.180575442044722 0.00107072926955335 NA NA NA hsa-miR-501-5p MAP2K1 1.15231083477882 2.98906150004088e-10 -1.22814648702538 4.27448032410174e-41 PITA -0.144135390798289 3.07397683406163e-08 NA NA NA hsa-miR-20a-5p MAP2K3 0.854326758727003 5.04256669663285e-07 -1.21754800169498 4.92442767488047e-26 miRTarBase -0.146114431767222 2.34481412513752e-05 NA NA NA hsa-miR-192-5p MAP3K1 -0.50188499512787 0.00344713341196035 0.0159561891588775 0.877325572084852 miRNAWalker2_validate -0.12056340177866 3.22770061138135e-05 NA NA NA hsa-miR-27b-3p MAP3K12 -0.823491817819754 9.20935302746823e-14 0.334893786989642 0.0179755392811318 miRNATAP -0.211348277410436 0.000513662281963951 NA NA NA hsa-miR-20a-5p MAP3K13 0.854326758727003 5.04256669663285e-07 -0.448996281023736 0.0575259551730977 miRNATAP -0.184087143328605 0.00601036434848416 NA NA NA hsa-miR-20a-5p MAP3K14 0.854326758727003 5.04256669663285e-07 -0.256732855579524 0.0805960527428211 MirTarget -0.157807215094265 0.000138930673437178 NA NA NA hsa-miR-20a-5p MAP3K2 0.854326758727003 5.04256669663285e-07 -0.770538748173389 6.13734867546361e-08 MirTarget;miRNATAP -0.25799642930204 1.23793599245169e-10 NA NA NA hsa-miR-20a-5p MAP3K5 0.854326758727003 5.04256669663285e-07 -1.33601122467136 1.03028348684945e-07 miRNATAP -0.349691468275886 1.01213992658686e-06 NA NA NA hsa-miR-20a-5p MAP3K8 0.854326758727003 5.04256669663285e-07 -0.159965748968671 0.44777579319131 MirTarget;miRNATAP -0.117316128957401 0.049568903288141 NA NA NA hsa-miR-20a-5p MAP7 0.854326758727003 5.04256669663285e-07 -1.05909886037011 4.31384656448488e-08 miRNATAP -0.25568560830628 3.61392749909034e-06 NA NA NA hsa-miR-148a-3p MAP7D2 -0.748702855596996 3.93313343865641e-07 0.763166018662374 0.0866664092768403 MirTarget -0.466762788951956 0.00132535874257167 NA NA NA hsa-miR-20a-5p MAP9 0.854326758727003 5.04256669663285e-07 -1.37818477884312 4.1786518609997e-07 miRNATAP -0.35926355321719 3.63734604244686e-06 NA NA NA hsa-miR-27b-3p MAPK7 -0.823491817819754 9.20935302746823e-14 0.305136164161477 0.000440978428375878 miRNATAP -0.123415319315889 0.000963752517439649 NA NA NA hsa-miR-27b-3p MAPK8IP3 -0.823491817819754 9.20935302746823e-14 1.01234491290533 3.03085078878221e-14 miRNATAP -0.159381047264504 0.00713313993309301 NA NA NA hsa-miR-20a-5p MAPRE2 0.854326758727003 5.04256669663285e-07 -0.72153637646019 1.20155521437307e-08 mirMAP -0.234453366692199 5.01188103722971e-11 NA NA NA hsa-miR-20a-5p MAPRE3 0.854326758727003 5.04256669663285e-07 -0.343621594450327 0.00477525960848748 MirTarget;miRNATAP -0.256639529832754 1.88980795269617e-14 NA NA NA hsa-miR-27b-3p MAPT -0.823491817819754 9.20935302746823e-14 2.58490052544186 2.18799071553378e-25 miRNATAP -0.53917741089395 1.73408872285656e-06 NA NA NA hsa-miR-148a-3p MARCH3 -0.748702855596996 3.93313343865641e-07 0.616348863709913 0.0025556726558054 MirTarget;miRNATAP -0.624353117326105 9.30331919035579e-23 NA NA NA hsa-miR-192-5p MARCH3 -0.50188499512787 0.00344713341196035 0.616348863709913 0.0025556726558054 mirMAP -0.295123164251184 2.82948293495367e-07 NA NA NA hsa-miR-20a-5p MARCH8 0.854326758727003 5.04256669663285e-07 -0.373395342611516 0.0861484318288631 MirTarget;miRNATAP -0.266166660232652 1.37890600926122e-05 NA NA NA hsa-miR-27b-3p MARCKS -0.823491817819754 9.20935302746823e-14 0.47891030020215 0.00159784808861844 MirTarget -0.223293023884137 0.000643271291176012 NA NA NA hsa-miR-20a-5p MAT2B 0.854326758727003 5.04256669663285e-07 -0.273105814463069 0.00263130083756265 MirTarget;miRNATAP -0.130845195810981 2.67912570648619e-07 NA NA NA hsa-miR-148a-3p MATN3 -0.748702855596996 3.93313343865641e-07 2.24574154450948 1.20068691324261e-08 MirTarget -0.571507102978337 1.13120648716878e-05 NA NA NA hsa-miR-27b-3p MATN3 -0.823491817819754 9.20935302746823e-14 2.24574154450948 1.20068691324261e-08 MirTarget;miRNATAP -0.87816733952884 2.77796099819256e-07 NA NA NA hsa-miR-148a-3p MBP -0.748702855596996 3.93313343865641e-07 -0.401034568218827 0.00152582531127159 mirMAP -0.101868769145895 0.0140733136781751 NA NA NA hsa-miR-20a-5p MBTPS1 0.854326758727003 5.04256669663285e-07 -0.204180275737213 0.00573895216061998 miRNATAP -0.117277483246402 1.17772683008292e-08 NA NA NA hsa-miR-192-5p MCAM -0.50188499512787 0.00344713341196035 1.33945352136389 1.93175099944524e-20 miRNAWalker2_validate -0.407079648231632 1.54803944429173e-23 NA NA NA hsa-miR-20a-5p MCC 0.854326758727003 5.04256669663285e-07 -2.36915505634884 5.46995786737825e-22 MirTarget -0.271809542484128 0.000202316721973451 NA NA NA hsa-miR-20a-5p MCL1 0.854326758727003 5.04256669663285e-07 -1.08478249996404 1.88833352070372e-27 MirTarget;miRNATAP -0.114471714846913 0.000140895848956066 23594563 Subsequent investigations revealed that miR-20a directly targeted myeloid cell leukemia sequence 1 Mcl-1 and reduced the endogenous protein level of Mcl-1 in HCC cells liver cancer hsa-miR-192-5p MCM10 -0.50188499512787 0.00344713341196035 3.44644537200841 1.46743341445993e-36 miRNAWalker2_validate -0.205997953722998 0.0151367215753814 NA NA NA hsa-miR-192-5p MCM3 -0.50188499512787 0.00344713341196035 1.38245898490982 6.59458276841991e-26 miRNAWalker2_validate -0.118151752469436 0.00283190558585697 NA NA NA hsa-miR-192-5p MCM6 -0.50188499512787 0.00344713341196035 1.68713872113643 5.47744551594301e-30 miRNAWalker2_validate -0.129535871289776 0.00415957553139546 NA NA NA hsa-miR-27b-3p MDGA1 -0.823491817819754 9.20935302746823e-14 1.09023577522186 0.00025808585973707 mirMAP -0.419485130139583 0.00116288148560143 NA NA NA hsa-miR-27b-3p MDH2 -0.823491817819754 9.20935302746823e-14 0.0705623377515829 0.50753860917769 miRNAWalker2_validate -0.104734148077956 0.0220775013193601 NA NA NA hsa-miR-19b-3p MECOM 0.601279551368824 0.00016685097085251 0.959512171082984 9.09579943703071e-08 miRNATAP -0.129331453668629 0.0196315279663432 NA NA NA hsa-miR-22-3p MECOM -0.628561621952407 1.33755558015523e-09 0.959512171082984 9.09579943703071e-08 miRNATAP -0.180980334358813 0.0330564397272789 NA NA NA hsa-miR-361-5p MECOM 0.233202959858696 0.00961572812255327 0.959512171082984 9.09579943703071e-08 miRanda -0.278956690972315 0.00517024358546618 NA NA NA hsa-miR-374a-5p MECOM 0.016390363747302 0.869784217438621 0.959512171082984 9.09579943703071e-08 mirMAP -0.37178528301155 3.21945126868006e-05 NA NA NA hsa-miR-374b-5p MECOM -0.307538028546424 0.0030079617545972 0.959512171082984 9.09579943703071e-08 mirMAP -0.372614882805562 1.35293538346028e-05 NA NA NA hsa-miR-455-5p MECOM -0.270546034117157 0.0581320703577731 0.959512171082984 9.09579943703071e-08 miRanda -0.34626889403173 1.80675931190258e-08 NA NA NA hsa-miR-148a-3p MECP2 -0.748702855596996 3.93313343865641e-07 0.263893569030019 0.000429500323071978 miRNATAP -0.107629546729185 9.50479455092943e-06 NA NA NA hsa-miR-192-5p MECP2 -0.50188499512787 0.00344713341196035 0.263893569030019 0.000429500323071978 mirMAP;miRNATAP -0.130299154032966 4.0946454337433e-10 NA NA NA hsa-miR-192-5p MED22 -0.50188499512787 0.00344713341196035 0.901475361439055 2.19971977737607e-20 miRNAWalker2_validate;mirMAP -0.169635883856321 2.43222104424426e-09 NA NA NA hsa-miR-192-5p MEIS2 -0.50188499512787 0.00344713341196035 0.156457406703811 0.32841086989024 miRNAWalker2_validate -0.251184999337731 1.85224113713703e-08 NA NA NA hsa-miR-27b-3p MEIS2 -0.823491817819754 9.20935302746823e-14 0.156457406703811 0.32841086989024 MirTarget;miRNATAP -0.201420413922627 0.00341615257701412 NA NA NA hsa-miR-92a-1-5p METRN 0.389443191151075 0.0644925359204601 -0.533107860852407 0.032685762629204 mirMAP -0.355882317667409 3.89988401563339e-10 NA NA NA hsa-miR-192-5p METTL9 -0.50188499512787 0.00344713341196035 0.228543330129342 0.0119977624175472 miRNAWalker2_validate -0.221384327901342 2.76868031081088e-19 NA NA NA hsa-miR-192-5p MEX3B -0.50188499512787 0.00344713341196035 0.521497613312576 0.00979968275068838 miRNAWalker2_validate -0.413107534163523 1.29160027577422e-13 NA NA NA hsa-miR-20a-5p MFAP3L 0.854326758727003 5.04256669663285e-07 -2.99511248620354 4.97173912475439e-19 MirTarget;miRNATAP -0.827194212004749 5.69897325485743e-18 NA NA NA hsa-miR-20a-5p MFN2 0.854326758727003 5.04256669663285e-07 -0.60468815586085 4.04345111138286e-11 MirTarget -0.140131360767352 8.41876408813981e-08 NA NA NA hsa-miR-192-5p MFSD10 -0.50188499512787 0.00344713341196035 0.829274707400239 3.50865672604536e-08 miRNAWalker2_validate -0.435263868555597 9.92627944751977e-27 NA NA NA hsa-miR-148a-3p MGAT4A -0.748702855596996 3.93313343865641e-07 0.104155687943847 0.347191347682603 MirTarget;miRNATAP -0.189467335208124 1.05295218983964e-07 NA NA NA hsa-miR-20a-5p MGAT5 0.854326758727003 5.04256669663285e-07 -0.048940912253241 0.86560089431757 mirMAP -0.323078633968526 7.22811007213867e-05 NA NA NA hsa-miR-148a-3p MITF -0.748702855596996 3.93313343865641e-07 -0.406319701896632 0.0146105141167573 miRNATAP -0.467580582447595 3.04864215131373e-19 20644734 miR 148 regulates Mitf in melanoma cells; Furthermore miR-148 was shown to affect Mitf mRNA expression in melanoma cells through a conserved binding site in the 3'UTR sequence of mouse and human Mitf; Our data show that miR-148 and miR-137 present an additional level of regulating Mitf expression in melanocytes and melanoma cells melanoma hsa-miR-27b-3p MITF -0.823491817819754 9.20935302746823e-14 -0.406319701896632 0.0146105141167573 miRNATAP -0.179489017011341 0.0124662237784175 NA NA NA hsa-miR-192-5p MKI67 -0.50188499512787 0.00344713341196035 3.30854921974502 2.49149463242045e-41 miRNAWalker2_validate;mirMAP -0.15986443725674 0.03876631267078 NA NA NA hsa-miR-148a-3p MLLT6 -0.748702855596996 3.93313343865641e-07 0.653121837157595 1.00755151884882e-10 mirMAP -0.162803763078442 1.0554539412223e-06 NA NA NA hsa-miR-27b-3p MLPH -0.823491817819754 9.20935302746823e-14 -0.644970890675596 0.0208638141164866 MirTarget -0.529922088939426 9.40951871153178e-06 NA NA NA hsa-miR-20a-5p MLXIP 0.854326758727003 5.04256669663285e-07 -0.153118946482325 0.153700787364517 miRNAWalker2_validate;MirTarget -0.125249220521966 3.24690509700645e-05 NA NA NA hsa-miR-148a-3p MMD -0.748702855596996 3.93313343865641e-07 -0.0416538737688885 0.789780769629193 miRNATAP -0.372734806931057 4.84148415492915e-14 NA NA NA hsa-miR-148a-3p MMP15 -0.748702855596996 3.93313343865641e-07 -0.201202119912763 0.130626873491951 MirTarget;miRNATAP -0.120782391393074 0.00539566749823154 NA NA NA hsa-miR-20a-5p MMP16 0.854326758727003 5.04256669663285e-07 -0.556297005522388 0.04844968434014 mirMAP -0.343341610850167 1.53217272980872e-05 NA NA NA hsa-miR-20a-5p MMP24 0.854326758727003 5.04256669663285e-07 0.184611798780092 0.309671788462752 MirTarget;miRNATAP -0.219332211542697 1.75072630868641e-05 NA NA NA hsa-miR-20a-5p MMP3 0.854326758727003 5.04256669663285e-07 0.206938536377007 0.549747904802987 MirTarget -0.30137535401111 0.00205862590490503 NA NA NA hsa-miR-148a-3p MNT -0.748702855596996 3.93313343865641e-07 0.184227791568378 0.0189335590228023 MirTarget;miRNATAP -0.134672890349733 9.4698522376505e-08 NA NA NA hsa-miR-20a-5p MOCOS 0.854326758727003 5.04256669663285e-07 -0.6837763432576 5.79876842070152e-05 mirMAP -0.258075523792502 7.21580665037759e-08 NA NA NA hsa-miR-148a-3p MOSPD1 -0.748702855596996 3.93313343865641e-07 0.488835757295254 0.000448347658243513 MirTarget;miRNATAP -0.134050229300976 0.00334048594892656 NA NA NA hsa-miR-148a-3p MPP2 -0.748702855596996 3.93313343865641e-07 0.359448868876671 0.193649765772268 mirMAP -0.576663912966332 7.06024094033857e-11 NA NA NA hsa-miR-192-5p MPPED2 -0.50188499512787 0.00344713341196035 0.656713801192978 0.0163326393553169 mirMAP -0.247409591002721 0.00142247867669735 NA NA NA hsa-miR-20a-5p MPPED2 0.854326758727003 5.04256669663285e-07 0.656713801192978 0.0163326393553169 mirMAP -0.269131241664383 0.00050838119290716 NA NA NA hsa-miR-192-5p MPZL1 -0.50188499512787 0.00344713341196035 0.782707469550616 4.62671433445359e-14 miRNAWalker2_validate -0.21525697920572 2.86773310660736e-13 NA NA NA hsa-miR-20a-5p MR1 0.854326758727003 5.04256669663285e-07 -0.0140226098593721 0.925161101378291 mirMAP -0.184347610917532 1.07534920484514e-05 NA NA NA hsa-miR-92a-1-5p MR1 0.389443191151075 0.0644925359204601 -0.0140226098593721 0.925161101378291 MirTarget -0.178103883068835 1.796033222659e-07 NA NA NA hsa-miR-125a-3p MSH3 -0.841683158494395 3.51202687176603e-05 -0.161343786741238 0.0575589260293181 miRanda -0.118807690934592 4.43923977822084e-09 NA NA NA hsa-miR-92b-3p MSH3 0.220374930803974 0.296187538889092 -0.161343786741238 0.0575589260293181 miRNAWalker2_validate -0.140228793554641 1.74398308418954e-13 NA NA NA hsa-miR-192-5p MSN -0.50188499512787 0.00344713341196035 -0.0535957526194801 0.689537550504795 miRNAWalker2_validate;MirTarget -0.292878639001823 1.40979531895973e-15 NA NA NA hsa-miR-192-5p MSRB3 -0.50188499512787 0.00344713341196035 -0.120755130016823 0.51722938086688 miRNAWalker2_validate -0.423410475326262 8.58947258953307e-17 NA NA NA hsa-miR-20a-5p MSRB3 0.854326758727003 5.04256669663285e-07 -0.120755130016823 0.51722938086688 mirMAP -0.245890793784045 2.55192562214054e-06 NA NA NA hsa-miR-20a-5p MTF1 0.854326758727003 5.04256669663285e-07 -0.000383067301068074 0.996459540723077 MirTarget -0.144552367927515 1.45063627382606e-09 NA NA NA hsa-miR-20a-5p MUC20 0.854326758727003 5.04256669663285e-07 -0.24196350030529 0.404864489685391 mirMAP -0.175175343045231 0.0334308652631991 NA NA NA hsa-miR-148a-3p MXRA7 -0.748702855596996 3.93313343865641e-07 0.0792703555372567 0.610154190820347 mirMAP -0.327411438179438 4.10632025038244e-11 NA NA NA hsa-miR-192-5p MYB -0.50188499512787 0.00344713341196035 0.832619773672674 0.00191922988334194 miRNAWalker2_validate -0.161558899446576 0.0348070283826992 NA NA NA hsa-miR-148a-3p MYBL1 -0.748702855596996 3.93313343865641e-07 1.1480718167108 4.98869165631426e-13 miRNATAP -0.223597573663347 2.53522339869195e-05 NA NA NA hsa-miR-20a-5p MYC 0.854326758727003 5.04256669663285e-07 -1.53204423111148 3.53987625613016e-10 miRNAWalker2_validate -0.165031814042356 0.0197576054298013 26012475 Finally miR-20a abrogated the TGF-β-mediated c-Myc repression a direct inhibitor of the CDKN1A promoter activation most likely by reducing the expression of specific MYC-regulating genes from the Smad/E2F-based core repressor complex colon cancer hsa-miR-20a-5p MYO10 0.854326758727003 5.04256669663285e-07 -1.59578787890497 5.76385780041621e-13 miRNATAP -0.365311951533274 9.32436479754336e-09 NA NA NA hsa-miR-148a-3p MYO5A -0.748702855596996 3.93313343865641e-07 0.557773632662129 0.000490007069603743 mirMAP -0.345280552201393 1.79580634840643e-11 NA NA NA hsa-miR-20a-5p MYO5A 0.854326758727003 5.04256669663285e-07 0.557773632662129 0.000490007069603743 mirMAP -0.166408397175256 0.00024596073719397 NA NA NA hsa-miR-192-5p N4BP3 -0.50188499512787 0.00344713341196035 1.8217286140426 3.52289215295134e-19 mirMAP -0.438310435315736 7.94117558497158e-14 NA NA NA hsa-miR-148a-3p NAP1L1 -0.748702855596996 3.93313343865641e-07 0.48873822323481 4.44413744556636e-06 MirTarget -0.222421584730968 9.79324697889936e-11 NA NA NA hsa-miR-148a-3p NAT14 -0.748702855596996 3.93313343865641e-07 0.762454549118796 2.23303909352019e-05 miRNATAP -0.456270487898184 1.74702579708855e-15 NA NA NA hsa-miR-148a-3p NAT8L -0.748702855596996 3.93313343865641e-07 1.21195978404762 0.000153977148692105 MirTarget -0.624254951064272 1.68451566801213e-09 NA NA NA hsa-miR-192-5p NAT8L -0.50188499512787 0.00344713341196035 1.21195978404762 0.000153977148692105 mirMAP -0.607552074927247 1.05556548107848e-11 NA NA NA hsa-miR-27b-3p NAT8L -0.823491817819754 9.20935302746823e-14 1.21195978404762 0.000153977148692105 miRNATAP -0.418909031811915 0.00255056833285611 NA NA NA hsa-miR-27b-3p NAV1 -0.823491817819754 9.20935302746823e-14 0.457357293208876 0.00149629098704196 miRNATAP -0.154734556101065 0.0130129836680515 NA NA NA hsa-miR-148a-3p NBEA -0.748702855596996 3.93313343865641e-07 -0.95438160847924 0.000354673661355781 miRNATAP -0.517605225217207 2.06161972192119e-09 NA NA NA hsa-miR-20a-5p NBL1 0.854326758727003 5.04256669663285e-07 0.411559687908337 0.0538190096622874 miRNATAP -0.212576305873646 0.00042454664006649 NA NA NA hsa-miR-148a-3p NCAM1 -0.748702855596996 3.93313343865641e-07 -3.20651653818541 4.82483086836138e-22 miRNATAP -0.269720143732448 0.0186234539799905 NA NA NA hsa-miR-192-5p NCAPH -0.50188499512787 0.00344713341196035 3.18695185270844 3.33326623129278e-40 miRNAWalker2_validate -0.26091051426793 0.000505758185848569 NA NA NA hsa-miR-192-5p NCEH1 -0.50188499512787 0.00344713341196035 -0.168281646804029 0.373785981981435 miRNAWalker2_validate -0.372404785674142 9.68584824490217e-13 NA NA NA hsa-miR-20a-5p NCEH1 0.854326758727003 5.04256669663285e-07 -0.168281646804029 0.373785981981435 MirTarget -0.217192619044951 4.49941518756095e-05 NA NA NA hsa-miR-20a-5p NCKAP5 0.854326758727003 5.04256669663285e-07 -1.99554121140322 2.30439992781689e-15 MirTarget;miRNATAP -0.34172743550512 3.13490750141241e-06 NA NA NA hsa-miR-192-5p NDE1 -0.50188499512787 0.00344713341196035 0.525156796072816 3.72868495053221e-06 miRNAWalker2_validate -0.164692563352345 2.91127523917972e-07 NA NA NA hsa-miR-20a-5p NDEL1 0.854326758727003 5.04256669663285e-07 -0.93256260809174 5.64997674586862e-21 MirTarget;miRNATAP -0.135613977825564 3.51075440125052e-06 NA NA NA hsa-miR-148a-3p NDOR1 -0.748702855596996 3.93313343865641e-07 1.05020501516652 5.12624788472277e-23 mirMAP -0.198297115609242 4.09966479091354e-08 NA NA NA hsa-miR-20a-5p NDRG4 0.854326758727003 5.04256669663285e-07 -0.54286699943328 0.0347192341596574 mirMAP -0.16047481349172 0.0280038658884103 NA NA NA hsa-miR-27b-3p NDUFS6 -0.823491817819754 9.20935302746823e-14 0.529305162889796 3.55320960048051e-05 miRNAWalker2_validate -0.120698677984857 0.0300386866553856 NA NA NA hsa-miR-148a-3p NEBL -0.748702855596996 3.93313343865641e-07 -1.60837717002858 3.41970971707568e-05 mirMAP -0.515068828584662 5.20804366302462e-05 NA NA NA hsa-miR-192-5p NEBL -0.50188499512787 0.00344713341196035 -1.60837717002858 3.41970971707568e-05 mirMAP -0.444164748552869 5.79787961566426e-05 NA NA NA hsa-miR-27b-3p NECAB1 -0.823491817819754 9.20935302746823e-14 -0.000563338784403067 0.99830111759913 MirTarget -0.292100236329217 0.0103193271064198 NA NA NA hsa-miR-92a-1-5p NECAB1 0.389443191151075 0.0644925359204601 -0.000563338784403067 0.99830111759913 MirTarget -0.237684469842667 9.71955392047764e-05 NA NA NA hsa-miR-27b-3p NEK2 -0.823491817819754 9.20935302746823e-14 4.21788709235454 1.27998914185694e-50 miRNATAP -0.775511487038549 1.1163500997741e-08 NA NA NA hsa-miR-148a-3p NEURL4 -0.748702855596996 3.93313343865641e-07 0.227746874329284 0.00320954632248109 MirTarget;miRNATAP -0.112466163069294 6.8940335334216e-06 NA NA NA hsa-miR-148a-3p NFAM1 -0.748702855596996 3.93313343865641e-07 -1.5126511002004 1.93686430698698e-15 mirMAP -0.282215369366512 1.02973421453975e-05 NA NA NA hsa-miR-20a-5p NFASC 0.854326758727003 5.04256669663285e-07 -0.522066844629388 0.0155574931536179 mirMAP -0.258189779448579 2.21454270602185e-05 NA NA NA hsa-miR-20a-5p NFIA 0.854326758727003 5.04256669663285e-07 -0.924685216157224 2.60745966247054e-13 mirMAP -0.220307604692219 1.17522520181388e-09 NA NA NA hsa-miR-20a-5p NFIB 0.854326758727003 5.04256669663285e-07 -0.473125743246742 0.000230272053316789 mirMAP;miRNATAP -0.237769487514429 3.03499805824516e-11 NA NA NA hsa-miR-20a-5p NFIC 0.854326758727003 5.04256669663285e-07 -0.577436174020039 0.00748919731318304 miRNATAP -0.257221821315235 2.44112891586052e-05 NA NA NA hsa-miR-92a-1-5p NFIC 0.389443191151075 0.0644925359204601 -0.577436174020039 0.00748919731318304 mirMAP -0.163800991652019 0.00107851242017675 NA NA NA hsa-miR-15a-5p NFKB1 0.349521211668244 0.000770735998804736 -0.538916955748098 1.42993670239858e-08 miRNAWalker2_validate -0.153048958379264 0.000730484492411411 NA NA NA hsa-miR-548j-5p NFKB1 0.251239647701947 0.171361975450222 -0.538916955748098 1.42993670239858e-08 MirTarget -0.106885227436574 4.88574003092244e-05 NA NA NA hsa-miR-92a-3p NFKB1 0.212391012518195 0.134292268089997 -0.538916955748098 1.42993670239858e-08 miRNAWalker2_validate -0.147016189975437 8.47280185007855e-06 NA NA NA hsa-miR-27b-3p NFKBID -0.823491817819754 9.20935302746823e-14 0.15868940224537 0.380896735951309 miRNATAP -0.268247051136389 0.000555043837990117 NA NA NA hsa-miR-20a-5p NHLRC3 0.854326758727003 5.04256669663285e-07 -0.752710457579298 8.05410213066884e-14 MirTarget -0.115813820031321 7.43742321072744e-05 NA NA NA hsa-miR-148a-3p NHS -0.748702855596996 3.93313343865641e-07 0.0267805163013115 0.897730201737297 MirTarget;miRNATAP -0.58530039907232 2.38805824257e-19 NA NA NA hsa-miR-20a-5p NHS 0.854326758727003 5.04256669663285e-07 0.0267805163013115 0.897730201737297 miRNATAP -0.245126122005119 2.85188428653405e-05 NA NA NA hsa-miR-27b-3p NHS -0.823491817819754 9.20935302746823e-14 0.0267805163013115 0.897730201737297 miRNATAP -0.264461277599143 0.00314226775451808 NA NA NA hsa-miR-192-5p NIN -0.50188499512787 0.00344713341196035 0.65727987135705 1.81289405977022e-08 miRNAWalker2_validate -0.161020480125805 1.320755580245e-06 26743688 MiR 192 suppresses the tumorigenicity of prostate cancer cells by targeting and inhibiting nin one binding protein prostate cancer hsa-miR-20a-5p NKIRAS1 0.854326758727003 5.04256669663285e-07 -1.03217749329624 2.29315553156374e-18 MirTarget;miRNATAP -0.185857979438144 6.6889869956806e-08 NA NA NA hsa-miR-27b-3p NMB -0.823491817819754 9.20935302746823e-14 1.75897686367225 1.31725530796709e-18 MirTarget -0.404969560167753 5.66051455838046e-06 NA NA NA hsa-miR-20a-5p NOL4 0.854326758727003 5.04256669663285e-07 -3.34785387311656 6.2589012007234e-19 miRNATAP -0.320425074528421 0.00409282207731523 NA NA NA hsa-miR-146b-3p NOS2 -1.20799545896423 2.19859530890688e-09 1.34188199912716 2.31721049529452e-07 MirTarget;miRNATAP -0.178469037014934 0.00416937467719295 NA NA NA hsa-miR-148a-3p NOVA1 -0.748702855596996 3.93313343865641e-07 -0.237953091882935 0.490244872279506 miRNATAP -0.784526571402052 8.59261064718394e-13 NA NA NA hsa-miR-27b-3p NOVA1 -0.823491817819754 9.20935302746823e-14 -0.237953091882935 0.490244872279506 miRNATAP -0.449530647378964 0.00243571143594966 NA NA NA hsa-miR-148a-3p NPEPL1 -0.748702855596996 3.93313343865641e-07 1.0134980247578 2.1959859851927e-21 MirTarget -0.275426794015186 8.58260763868164e-15 NA NA NA hsa-miR-27b-3p NPEPPS -0.823491817819754 9.20935302746823e-14 0.261825419108992 0.00402637895532677 miRNAWalker2_validate;MirTarget -0.18267052964986 2.59424625961267e-06 NA NA NA hsa-miR-192-5p NPNT -0.50188499512787 0.00344713341196035 0.531754123141975 0.0583025915811082 miRNAWalker2_validate -0.467076031724044 2.50656825736623e-09 NA NA NA hsa-miR-148a-3p NPTX1 -0.748702855596996 3.93313343865641e-07 0.929025880461533 0.00584289763512414 miRNATAP -1.16655047743286 9.17100827578766e-30 NA NA NA hsa-miR-20a-5p NPTX1 0.854326758727003 5.04256669663285e-07 0.929025880461533 0.00584289763512414 mirMAP -0.27668254450585 0.00385588968114642 NA NA NA hsa-miR-27b-3p NPTX1 -0.823491817819754 9.20935302746823e-14 0.929025880461533 0.00584289763512414 mirMAP -0.427830906679308 0.00329514659906769 NA NA NA hsa-miR-192-5p NPTXR -0.50188499512787 0.00344713341196035 -0.560890830244132 0.0974541871007386 miRNAWalker2_validate -0.558598861403254 3.29441205098301e-09 NA NA NA hsa-miR-20a-5p NPTXR 0.854326758727003 5.04256669663285e-07 -0.560890830244132 0.0974541871007386 mirMAP -0.316277236819742 0.00095246636309681 NA NA NA hsa-miR-148a-3p NR2C2AP -0.748702855596996 3.93313343865641e-07 1.32716879157984 4.32641725625968e-31 MirTarget -0.218700998017347 3.7715743430841e-08 NA NA NA hsa-miR-148a-3p NRARP -0.748702855596996 3.93313343865641e-07 0.806873954048561 5.97890763868229e-07 MirTarget -0.408607463172978 2.94880871586574e-15 NA NA NA hsa-let-7b-5p NRAS -0.959013717270803 5.95127281258643e-11 0.301156333096785 0.000285671613438218 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.105903409272711 8.57245668973746e-05 20607356 Transfection of let-7 miRNA reduced expression of pan-RAS N-RAS and K-RAS in the glioblastoma cells glioblastoma hsa-miR-126-5p NRAS -0.428561469405594 6.6035585844222e-05 0.301156333096785 0.000285671613438218 mirMAP -0.145651073417946 0.000106824688349933 NA NA NA hsa-miR-145-5p NRAS -1.4795885711477 6.47308361543414e-16 0.301156333096785 0.000285671613438218 miRNAWalker2_validate;MirTarget;miRNATAP -0.120395847533196 1.03194548202048e-08 26973415 miR-145 expression was significantly downregulated in colon cancer tissues with its expression in normal colonic tissues being 4-5-fold higher two sample t test P < 0.05 whereas N-ras expression showed the opposite trend colon cancer hsa-miR-22-3p NRAS -0.628561621952407 1.33755558015523e-09 0.301156333096785 0.000285671613438218 MirTarget;miRNATAP -0.287363482934569 1.84836871548684e-14 NA NA NA hsa-miR-29a-3p NRAS -0.856762511178136 4.65330336378459e-12 0.301156333096785 0.000285671613438218 miRNATAP -0.111209986118726 0.000497462508043792 NA NA NA hsa-miR-29b-3p NRAS -0.348885528720517 0.0121441341291285 0.301156333096785 0.000285671613438218 miRNATAP -0.163441778679427 1.31476396622707e-08 NA NA NA hsa-miR-29c-3p NRAS -1.4367517608807 1.61767774905781e-21 0.301156333096785 0.000285671613438218 miRNATAP -0.195416271463693 3.04370398757482e-15 NA NA NA hsa-miR-664a-3p NRAS 0.485807855553031 0.000732553249798598 0.301156333096785 0.000285671613438218 MirTarget -0.123577371649095 9.58480979576424e-06 NA NA NA hsa-miR-148a-3p NRP1 -0.748702855596996 3.93313343865641e-07 -0.0892756788072155 0.498410902584577 miRNATAP -0.18925467975584 9.1215690162959e-06 26967387 Mechanistically miR-148a appears to suppress the extravasation process of cancer cells likely by targeting two genes WNT1 and NRP1 in a cell non-autonomous manner breast cancer hsa-miR-27b-3p NSD1 -0.823491817819754 9.20935302746823e-14 0.62757997714685 2.58183062912293e-14 miRNATAP -0.109422770536978 0.00269941190094211 NA NA NA hsa-miR-20a-5p NTN4 0.854326758727003 5.04256669663285e-07 -1.69514452471032 1.94972293728933e-19 MirTarget;miRNATAP -0.562725693111189 5.9049386822628e-27 NA NA NA hsa-miR-20a-5p NUBPL 0.854326758727003 5.04256669663285e-07 -0.487181955870277 0.000338824031290841 mirMAP -0.193617400121834 4.24127360189023e-07 NA NA NA hsa-miR-148a-3p OBSCN -0.748702855596996 3.93313343865641e-07 0.486867072596689 0.143711952566939 mirMAP -0.963676081304784 1.74328515884929e-20 NA NA NA hsa-miR-192-5p OGFRL1 -0.50188499512787 0.00344713341196035 -0.0390871680110974 0.773149067173146 miRNAWalker2_validate -0.281905869784042 3.56744239803102e-14 NA NA NA hsa-miR-27b-3p OLA1 -0.823491817819754 9.20935302746823e-14 0.52316411098601 2.99376745478249e-10 mirMAP -0.100559995408859 0.00574171838670775 NA NA NA hsa-miR-148a-3p ORAI2 -0.748702855596996 3.93313343865641e-07 0.147939436354318 0.336648923993268 mirMAP -0.628934430358564 3.04155769826223e-44 NA NA NA hsa-miR-192-5p ORAI2 -0.50188499512787 0.00344713341196035 0.147939436354318 0.336648923993268 mirMAP -0.542034181754501 1.59692192661204e-43 NA NA NA hsa-miR-27b-3p ORAI2 -0.823491817819754 9.20935302746823e-14 0.147939436354318 0.336648923993268 mirMAP -0.191637385984906 0.00377868186094634 NA NA NA hsa-miR-192-5p OSBPL10 -0.50188499512787 0.00344713341196035 -0.476374175815799 0.0254876734402078 miRNAWalker2_validate -0.484281305155656 1.07042567892179e-16 NA NA NA hsa-miR-20a-5p OSBPL5 0.854326758727003 5.04256669663285e-07 -0.232687135902777 0.200278988219421 miRNATAP -0.172938092478945 0.000747897043301927 NA NA NA hsa-miR-20a-5p OSR1 0.854326758727003 5.04256669663285e-07 0.85668860217344 0.00884127717216095 MirTarget;miRNATAP -0.448880355184299 1.08383075736431e-06 NA NA NA hsa-miR-192-5p OTUD3 -0.50188499512787 0.00344713341196035 0.701071239885856 4.04593404284281e-08 miRNAWalker2_validate -0.121855348182671 0.000889895702798122 NA NA NA hsa-miR-20a-5p OTUD4 0.854326758727003 5.04256669663285e-07 -0.781147538845887 2.89406618341624e-12 miRNATAP -0.171495159155073 9.09646779950092e-08 NA NA NA hsa-miR-148a-3p OTX1 -0.748702855596996 3.93313343865641e-07 3.02229789234294 1.88083127727288e-19 miRNATAP -0.710081313126758 2.7674669266848e-10 NA NA NA hsa-miR-148a-3p PACS2 -0.748702855596996 3.93313343865641e-07 0.778484820044494 1.37066720672879e-21 mirMAP -0.232363228345673 5.01661787042785e-18 NA NA NA hsa-miR-20a-5p PAFAH1B1 0.854326758727003 5.04256669663285e-07 -0.434065106493069 1.93053961424578e-10 MirTarget;miRNATAP -0.13262019175507 4.32224535325188e-12 NA NA NA hsa-miR-20a-5p PAFAH1B2 0.854326758727003 5.04256669663285e-07 -0.49682050496285 0.00261299670984924 MirTarget;miRNATAP -0.198399147598427 2.07666220081291e-05 NA NA NA hsa-miR-148a-3p PAG1 -0.748702855596996 3.93313343865641e-07 -0.0641776217701535 0.737132600565642 MirTarget -0.299690578625903 1.21889656248684e-06 NA NA NA hsa-miR-192-5p PAK6 -0.50188499512787 0.00344713341196035 0.189417226280461 0.547602921696693 miRNAWalker2_validate -0.370069240297406 2.99780053131704e-05 NA NA NA hsa-miR-148a-3p PAN3 -0.748702855596996 3.93313343865641e-07 0.0449402615838541 0.627403000327265 miRNAWalker2_validate -0.103849251615092 0.000540183980733424 NA NA NA hsa-miR-20a-5p PAPD5 0.854326758727003 5.04256669663285e-07 -0.465833219458179 6.1500280151066e-07 mirMAP -0.135919034114632 2.68881804105274e-07 NA NA NA hsa-miR-20a-5p PARK2 0.854326758727003 5.04256669663285e-07 -0.287668490464694 0.172950123873518 mirMAP -0.182126283767888 0.00228235578762873 NA NA NA hsa-miR-192-5p PARM1 -0.50188499512787 0.00344713341196035 0.492215081013945 0.0241931172963899 miRNAWalker2_validate;mirMAP -0.333971237723307 4.76225412561361e-08 NA NA NA hsa-miR-192-5p PASK -0.50188499512787 0.00344713341196035 0.811499355321663 2.31433002104328e-09 miRNAWalker2_validate -0.135088754737217 0.000552979463699365 NA NA NA hsa-miR-20a-5p PBX1 0.854326758727003 5.04256669663285e-07 -1.3362034667203 5.80856733969378e-07 mirMAP -0.167472755856604 0.0294148534171729 NA NA NA hsa-miR-192-5p PCDH7 -0.50188499512787 0.00344713341196035 -1.76464420465503 6.29135849130623e-08 miRNAWalker2_validate -0.546455946718252 3.39158982574729e-09 NA NA NA hsa-miR-20a-5p PCDHA11 0.854326758727003 5.04256669663285e-07 -1.46456579546239 0.000248254184143325 MirTarget -0.325273998106852 0.00431756249615817 NA NA NA hsa-miR-20a-5p PCDHA12 0.854326758727003 5.04256669663285e-07 -2.68228512919554 1.22349401150652e-09 MirTarget -0.56635301040964 7.84695704223838e-06 NA NA NA hsa-miR-20a-5p PCDHA13 0.854326758727003 5.04256669663285e-07 -2.25664029288571 8.67102156279892e-07 MirTarget -0.586484966556765 7.21344070675617e-06 NA NA NA hsa-miR-20a-5p PCDHAC1 0.854326758727003 5.04256669663285e-07 -2.39947483963875 3.46248760946361e-10 MirTarget -0.489261768578764 8.5466725444888e-06 NA NA NA hsa-miR-20a-5p PCDHAC2 0.854326758727003 5.04256669663285e-07 -2.81338526483965 3.55719413756446e-10 MirTarget -0.6966287827296 5.55532984843863e-08 NA NA NA hsa-miR-20a-5p PCYT1A 0.854326758727003 5.04256669663285e-07 -0.115598905849767 0.125639430650331 mirMAP -0.107568239494339 3.08655718171154e-07 NA NA NA hsa-miR-20a-5p PDCD1LG2 0.854326758727003 5.04256669663285e-07 -1.71871038152299 5.07295006749358e-14 MirTarget -0.412141774307485 3.1199013893093e-10 NA NA NA hsa-miR-148a-3p PDE5A -0.748702855596996 3.93313343865641e-07 0.186921756686946 0.309659365294452 MirTarget -0.553041668936523 3.21460058912989e-22 NA NA NA hsa-miR-20a-5p PDE7B 0.854326758727003 5.04256669663285e-07 -2.15823176849595 1.26609046048699e-26 mirMAP;miRNATAP -0.402508154704112 1.59163039354182e-11 NA NA NA hsa-miR-20a-5p PDGFRA 0.854326758727003 5.04256669663285e-07 -3.44515402293711 2.35408080284508e-16 MirTarget;miRNATAP -0.429411714989606 0.000497563648177803 NA NA NA hsa-miR-192-5p PDLIM3 -0.50188499512787 0.00344713341196035 -0.00843150695562267 0.968939178058972 miRNAWalker2_validate -0.496585206955558 4.0087952271627e-17 NA NA NA hsa-miR-192-5p PDP1 -0.50188499512787 0.00344713341196035 -0.55248328428444 0.00829430941999616 MirTarget -0.458563186270701 1.57682601421953e-15 NA NA NA hsa-miR-27b-3p PDXK -0.823491817819754 9.20935302746823e-14 0.60795962520192 3.81588352286127e-09 miRNATAP -0.120075908333961 0.00788884207825353 NA NA NA hsa-miR-148a-3p PEA15 -0.748702855596996 3.93313343865641e-07 1.12311402840601 1.26777023794476e-31 MirTarget -0.164965212390181 8.2875656209855e-07 NA NA NA hsa-miR-192-5p PFKFB2 -0.50188499512787 0.00344713341196035 1.02845639301179 4.08475002850898e-12 mirMAP -0.112331651767296 0.00926130538928353 NA NA NA hsa-miR-20a-5p PFKFB3 0.854326758727003 5.04256669663285e-07 -1.30750392590811 6.72544029163249e-08 MirTarget -0.271681350187159 9.01121015520368e-05 NA NA NA hsa-miR-27b-3p PFKM -0.823491817819754 9.20935302746823e-14 0.138045606565713 0.433467052903604 MirTarget -0.421756812414256 1.64470387651258e-08 NA NA NA hsa-miR-20a-5p PFKP 0.854326758727003 5.04256669663285e-07 0.709669274361661 0.00796476514189581 MirTarget -0.268242425315447 0.000398143638122438 NA NA NA hsa-miR-20a-5p PFN2 0.854326758727003 5.04256669663285e-07 -1.30384490866722 4.73283772543551e-07 miRNATAP -0.152671827589902 0.0404006927595731 NA NA NA hsa-miR-20a-5p PGK1 0.854326758727003 5.04256669663285e-07 0.216934441634805 0.0428574353274189 miRNAWalker2_validate -0.150883278607544 4.81198111338975e-07 NA NA NA hsa-miR-20a-5p PGM2L1 0.854326758727003 5.04256669663285e-07 0.0325808937730736 0.823878768591522 MirTarget;miRNATAP -0.140349823227095 0.000670544685701233 NA NA NA hsa-miR-27b-3p PGM2L1 -0.823491817819754 9.20935302746823e-14 0.0325808937730736 0.823878768591522 miRNATAP -0.234323502588402 0.000184297638644297 NA NA NA hsa-miR-192-5p PGR -0.50188499512787 0.00344713341196035 -2.1793358458203 1.59838886951673e-10 mirMAP -0.423797559048497 1.58785226195653e-05 NA NA NA hsa-miR-20a-5p PGR 0.854326758727003 5.04256669663285e-07 -2.1793358458203 1.59838886951673e-10 mirMAP -0.672733226493956 2.97305308992447e-12 NA NA NA hsa-miR-192-5p PHF19 -0.50188499512787 0.00344713341196035 1.31515412555065 1.20077313718174e-18 miRNAWalker2_validate -0.222092476769903 3.69245912036561e-07 NA NA NA hsa-miR-192-5p PHF21A -0.50188499512787 0.00344713341196035 0.536739369729245 3.79383887055722e-09 mirMAP -0.186935978648832 2.3371831640115e-13 NA NA NA hsa-miR-27b-3p PHF21A -0.823491817819754 9.20935302746823e-14 0.536739369729245 3.79383887055722e-09 mirMAP -0.192230089570725 1.10894919490395e-06 NA NA NA hsa-miR-20a-5p PHLPP2 0.854326758727003 5.04256669663285e-07 -0.0462325263383927 0.691559726183747 miRNATAP -0.267319009474098 3.22360794507594e-17 NA NA NA hsa-miR-27b-3p PHLPP2 -0.823491817819754 9.20935302746823e-14 -0.0462325263383927 0.691559726183747 MirTarget;miRNATAP -0.140894596676105 0.00484377792767415 NA NA NA hsa-miR-192-5p PHTF1 -0.50188499512787 0.00344713341196035 -0.0638230799417907 0.575687988687985 miRNAWalker2_validate -0.161998655473504 3.67704204137034e-07 NA NA NA hsa-miR-192-5p PHTF2 -0.50188499512787 0.00344713341196035 0.479833616664147 1.04897601040811e-06 miRNAWalker2_validate -0.18439724972846 2.03367562069468e-11 NA NA NA hsa-miR-20a-5p PHYHIP 0.854326758727003 5.04256669663285e-07 -0.612790074176789 0.0083593891744158 miRNATAP -0.243012272447005 0.000219193011615353 NA NA NA hsa-miR-342-3p PIAS1 -0.319677314984262 0.0449813878317147 0.14110668905439 0.111009722342972 miRanda -0.127221288569843 1.97391983714843e-06 NA NA NA hsa-miR-192-5p PIF1 -0.50188499512787 0.00344713341196035 2.41082297409356 3.54735544684265e-24 miRNAWalker2_validate -0.172432715063759 0.0159099494489366 NA NA NA hsa-miR-148a-3p PIK3IP1 -0.748702855596996 3.93313343865641e-07 0.504536960127542 0.00150104183804736 MirTarget -0.412399483927594 2.45708221476412e-16 NA NA NA hsa-miR-103a-3p PIK3R1 0.765568928457606 3.05497476509383e-12 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.187692597616198 0.00702590214654354 NA NA NA hsa-miR-106b-5p PIK3R1 0.648901865047099 8.24870862047885e-09 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.369244291882445 4.59379549667075e-08 NA NA NA hsa-miR-1301-3p PIK3R1 1.12156714169769 4.22404125385203e-10 -0.891953424131491 1.38465728969785e-08 MirTarget -0.26088137729301 3.97606431390706e-10 NA NA NA hsa-miR-132-3p PIK3R1 0.323796239695997 0.00272093067935091 -0.891953424131491 1.38465728969785e-08 MirTarget -0.517351445825174 2.17222827385203e-13 NA NA NA hsa-miR-15b-5p PIK3R1 0.230566941413564 0.0824765001857479 -0.891953424131491 1.38465728969785e-08 MirTarget -0.132325827339178 0.0249531550846148 NA NA NA hsa-miR-17-5p PIK3R1 0.698861147045461 2.43854106455398e-05 -0.891953424131491 1.38465728969785e-08 MirTarget;TargetScan;miRNATAP -0.213954808771155 3.8587060059728e-06 NA NA NA hsa-miR-185-5p PIK3R1 0.480006257154717 6.35758891340152e-07 -0.891953424131491 1.38465728969785e-08 miRNATAP -0.255181123475439 0.00153792085091181 NA NA NA hsa-miR-188-5p PIK3R1 1.11646899351496 9.56686958408598e-11 -0.891953424131491 1.38465728969785e-08 MirTarget -0.178093775716465 5.33015486626271e-05 NA NA NA hsa-miR-200c-3p PIK3R1 -0.104675615392797 0.716957669484981 -0.891953424131491 1.38465728969785e-08 mirMAP -0.105107802462856 9.06963579759966e-05 NA NA NA hsa-miR-20a-5p PIK3R1 0.854326758727003 5.04256669663285e-07 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.137431012149634 0.00237710222818209 NA NA NA hsa-miR-21-5p PIK3R1 1.51084295924322 1.54551622173259e-34 -0.891953424131491 1.38465728969785e-08 miRNAWalker2_validate;MirTarget;miRNATAP -0.626634426633867 6.01244523464713e-31 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-212-3p PIK3R1 -0.288359631986802 0.100392159518997 -0.891953424131491 1.38465728969785e-08 MirTarget -0.258090192317157 3.95293509038579e-09 NA NA NA hsa-miR-221-3p PIK3R1 1.12244756358612 3.48370308238012e-13 -0.891953424131491 1.38465728969785e-08 MirTarget -0.217914846238424 7.87055620620445e-06 NA NA NA hsa-miR-222-3p PIK3R1 1.08574156066353 1.76407192348131e-11 -0.891953424131491 1.38465728969785e-08 MirTarget -0.256619417997498 3.41697791848384e-08 NA NA NA hsa-miR-324-3p PIK3R1 0.260348469146494 0.0506141704203545 -0.891953424131491 1.38465728969785e-08 MirTarget;PITA;miRNATAP -0.281792149179102 1.26555231509763e-06 NA NA NA hsa-miR-330-3p PIK3R1 -0.332364259424489 0.0316051913061459 -0.891953424131491 1.38465728969785e-08 MirTarget;PITA;miRNATAP -0.212492102885122 3.44445995574159e-05 NA NA NA hsa-miR-338-5p PIK3R1 -0.221898432884726 0.252390988727086 -0.891953424131491 1.38465728969785e-08 PITA -0.143685656767977 0.000366657184559181 NA NA NA hsa-miR-409-3p PIK3R1 -0.499649792570937 0.0526751181520117 -0.891953424131491 1.38465728969785e-08 mirMAP -0.110448878014769 0.000237041711390918 NA NA NA hsa-miR-493-5p PIK3R1 -0.198321662045422 0.502870277689198 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.103739426368655 7.76271840065789e-05 NA NA NA hsa-miR-582-5p PIK3R1 -0.680189083316822 0.00103755166534107 -0.891953424131491 1.38465728969785e-08 mirMAP -0.138461163257927 0.00021364752999012 NA NA NA hsa-miR-589-3p PIK3R1 1.16846704028095 5.88525574424201e-11 -0.891953424131491 1.38465728969785e-08 mirMAP -0.21021578613876 1.13421126603334e-06 NA NA NA hsa-miR-590-5p PIK3R1 -0.103355559980404 0.310027295317092 -0.891953424131491 1.38465728969785e-08 MirTarget;PITA;miRanda;miRNATAP -0.299776876388425 9.9413226282672e-05 NA NA NA hsa-miR-629-3p PIK3R1 -0.315338123880353 0.119091248294946 -0.891953424131491 1.38465728969785e-08 MirTarget -0.182940394280375 3.19896248240917e-06 NA NA NA hsa-miR-93-5p PIK3R1 1.39518349670953 2.84167728726712e-25 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.319783065556515 2.89613370212511e-09 NA NA NA hsa-miR-148a-3p PITPNM3 -0.748702855596996 3.93313343865641e-07 -3.87084899319612 7.38035528475542e-40 mirMAP -0.339199491738163 0.00130873355554756 NA NA NA hsa-miR-20a-5p PKD2 0.854326758727003 5.04256669663285e-07 -0.661271085670887 4.60860116109786e-05 MirTarget;miRNATAP -0.370799761416449 1.04110265083866e-16 NA NA NA hsa-miR-27b-3p PKIA -0.823491817819754 9.20935302746823e-14 0.259803934002916 0.404559580397709 MirTarget;miRNATAP -0.484500368486809 0.000290869590531062 NA NA NA hsa-miR-192-5p PKP1 -0.50188499512787 0.00344713341196035 0.100017778193532 0.757646246120147 mirMAP -0.417541080148801 4.50419320208487e-06 NA NA NA hsa-miR-20a-5p PLA2G12A 0.854326758727003 5.04256669663285e-07 -0.791023748042462 1.18231931629012e-15 mirMAP -0.130236012494097 5.73845333718432e-06 NA NA NA hsa-miR-192-5p PLAU -0.50188499512787 0.00344713341196035 0.959311155204742 3.74075251162113e-09 miRNAWalker2_validate -0.53675875465802 1.47466599529483e-35 NA NA NA hsa-miR-192-5p PLCE1 -0.50188499512787 0.00344713341196035 1.83443085070885 1.01603163205123e-17 miRNAWalker2_validate -0.326507983373389 1.74795253782827e-07 NA NA NA hsa-miR-20a-5p PLEKHA2 0.854326758727003 5.04256669663285e-07 -0.969562161830209 1.2701299627881e-11 mirMAP -0.130098561168356 0.0017227130047032 NA NA NA hsa-miR-20a-5p PLEKHA3 0.854326758727003 5.04256669663285e-07 -0.403395146399148 1.65329256934451e-07 MirTarget -0.159692015497215 8.83759148098903e-14 NA NA NA hsa-miR-148a-3p PLEKHB2 -0.748702855596996 3.93313343865641e-07 0.00560086814314076 0.957822592701461 MirTarget -0.38563730310529 6.3296530559203e-34 NA NA NA hsa-miR-192-5p PLEKHG2 -0.50188499512787 0.00344713341196035 1.10126051664067 3.21863245758859e-16 miRNAWalker2_validate -0.286918579075941 9.78124593620595e-14 NA NA NA hsa-miR-27b-3p PLEKHH1 -0.823491817819754 9.20935302746823e-14 1.25039195218202 7.83074573807631e-12 miRNATAP -0.469231159638081 3.56029835326662e-09 NA NA NA hsa-miR-27b-3p PLEKHJ1 -0.823491817819754 9.20935302746823e-14 0.462053181192892 6.74000515110976e-05 miRNATAP -0.110826200534401 0.0276342009771135 NA NA NA hsa-miR-20a-5p PLEKHM1 0.854326758727003 5.04256669663285e-07 -0.0220349253822141 0.762787471995565 MirTarget;miRNATAP -0.123971374860899 7.65950112554812e-10 NA NA NA hsa-miR-20a-5p PLEKHM3 0.854326758727003 5.04256669663285e-07 -0.44092979439459 0.000176550137879797 miRNAWalker2_validate;MirTarget -0.11653447948224 0.000479658943226706 NA NA NA hsa-miR-20a-5p PLEKHO2 0.854326758727003 5.04256669663285e-07 -0.28499524807241 0.0207483976175056 MirTarget;miRNATAP -0.118000868708978 0.000702836197642093 NA NA NA hsa-let-7b-5p PLK1 -0.959013717270803 5.95127281258643e-11 3.58200503456178 1.01936996392609e-41 miRNAWalker2_validate -0.508374715415364 7.45675351637923e-08 NA NA NA hsa-miR-100-5p PLK1 -0.783576782126614 0.000219958772262677 3.58200503456178 1.01936996392609e-41 miRNAWalker2_validate;miRTarBase -0.609428308452059 1.35398975085084e-21 23842624;23151088;22246341;25537513;22120675;21636267 In HCC tissues miR-100 expression was inversely correlated with the expression of plk1 protein r = -0.418; P = 0.029; Therefore downregulation of miR-100 was correlated with progressive pathological feature and poor prognosis in HCC patients and miR-100 could function as a tumor suppressor by targeting plk1;MicroRNA 100 is a potential molecular marker of non small cell lung cancer and functions as a tumor suppressor by targeting polo like kinase 1; By using microRNA miR target prediction algorithms we identified miR-100 that might potentially bind the 3'-untranslated region of PLK1 transcripts; The purpose of this study was to investigate the roles of miR-100 and its association with PLK1 in NSCLC development; Finally the effects of miR-100 expression on growth apoptosis and cell cycle of NSCLC cells by posttranscriptionally regulating PLK1 expression were determined; Meanwhile miR-100 mimics could significantly inhibit PLK1 mRNA and protein expression and reduce the luciferase activity of a PLK1 3' untranslated region-based reporter construct in A549 cells; Furthermore small interfering RNA siRNA-mediated PLK1 downregulation could mimic the effects of miR-100 mimics while PLK1 overexpression could partially rescue the phenotypical changes of NSCLC cells induced by miR-100 mimics; Our findings indicate that low miR-100 may be a poor prognostic factor for NSCLC patients and functions as a tumor suppressor by posttranscriptionally regulating PLK1 expression;Together these results suggest that low miR-100 expression may be an independent poor prognostic factor and miR-100 can function as a tumor suppressor by targeting PLK1 in human EOCs;Here we show that miR-100 inhibits maintenance and expansion of BrCSCs in basal-like cancer through Polo-like kinase1 Plk1 down-regulation;MiR 100 resensitizes docetaxel resistant human lung adenocarcinoma cells SPC A1 to docetaxel by targeting Plk1; Knock-down of Plk1 which was a direct target of miR-100 yielded similar effects as that of ectopic miR-100 expression; The inverse correlation between miR-100 and Plk1 expression was also detected in nude mice SPC-A1/DTX tumor xenografts and clinical lung adenocarcinoma tissues and was proved to be related with the in vivo response to docetaxel; Thus our results suggested that down-regulation of miR-100 could lead to Plk1 over-expression and eventually to docetaxel chemoresistance of human lung adenocarcinoma;Reduced miR 100 expression in cervical cancer and precursors and its carcinogenic effect through targeting PLK1 protein; Through modulating miR-100 expression using miR-100 inhibitor or mimic in vitro cell growth cycle and apoptosis were tested separately by MTT or flow cytometry and meanwhile Polo-like kinase1 PLK1 mRNA and protein expressions were detected by qRT-PCR and immunoblotting; The expression of PLK1 in 125 cervical tissues was also examined by immunohistochemical staining and the correlation between miR-100 and PLK1 expression in the same tissues was analysed; The modulation of miR-100 expression remarkably influenced cell proliferation cycle and apoptosis as well as the level of PLK1 protein but not mRNA in vitro experiments; PLK1 expression was negatively correlated with miR-100 expression in CIN3 and cervical cancer tissues; The reduced miR-100 expression participates in the development of cervical cancer at least partly through loss of inhibition to target gene PLK1 which probably occurs in a relative late phase of carcinogenesis progression;worse prognosis;;;;drug resistance;tumorigenesis liver cancer;lung squamous cell cancer;ovarian cancer;breast cancer;lung cancer;cervical and endocervical cancer hsa-miR-486-5p PLK1 -1.77766890600022 2.9071717929922e-14 3.58200503456178 1.01936996392609e-41 miRanda -0.373122790226321 1.30117161322891e-10 NA NA NA hsa-miR-505-5p PLK1 -0.768282569967001 1.14662846595407e-05 3.58200503456178 1.01936996392609e-41 MirTarget -0.372253566265304 3.64975232604557e-06 NA NA NA hsa-miR-874-3p PLK1 -1.07043026298634 2.09564226589678e-07 3.58200503456178 1.01936996392609e-41 miRNAWalker2_validate -0.236755899629093 0.000522664320516165 NA NA NA hsa-miR-192-5p PLK4 -0.50188499512787 0.00344713341196035 2.24309967329393 2.25251967570101e-29 miRNAWalker2_validate -0.182298256651921 0.00265855667422409 NA NA NA hsa-miR-20a-5p PLS1 0.854326758727003 5.04256669663285e-07 -0.343978850494421 0.037888216094636 MirTarget;miRNATAP -0.14356134282351 0.00220626565740312 NA NA NA hsa-miR-20a-5p PLSCR4 0.854326758727003 5.04256669663285e-07 -2.21840265832849 1.26161246830308e-31 MirTarget -0.246445794720824 1.93225822678379e-05 NA NA NA hsa-miR-148a-3p PLXDC1 -0.748702855596996 3.93313343865641e-07 2.83957658613902 7.43247270561304e-40 mirMAP -0.883939730974154 2.16067872112889e-35 NA NA NA hsa-miR-27b-3p PLXND1 -0.823491817819754 9.20935302746823e-14 0.69765536803745 4.01395417482674e-09 MirTarget;miRNATAP -0.18938553597424 0.000254784159367628 NA NA NA hsa-miR-20a-5p PNPO 0.854326758727003 5.04256669663285e-07 -0.728889693924063 7.74532063797697e-08 MirTarget -0.213850211080156 2.65499941117499e-08 NA NA NA hsa-miR-148a-3p PODXL -0.748702855596996 3.93313343865641e-07 1.44094860371079 1.88695975215765e-18 MirTarget -0.369390838413584 1.61834113480849e-11 NA NA NA hsa-miR-192-5p PODXL -0.50188499512787 0.00344713341196035 1.44094860371079 1.88695975215765e-18 miRNAWalker2_validate -0.297812792140288 4.48715853597399e-10 NA NA NA hsa-miR-27b-3p PODXL -0.823491817819754 9.20935302746823e-14 1.44094860371079 1.88695975215765e-18 mirMAP -0.223584225898895 0.00247322335562612 NA NA NA hsa-miR-148a-3p POFUT2 -0.748702855596996 3.93313343865641e-07 0.257896779627181 0.00304062880467066 mirMAP -0.123524909535533 1.20021947046028e-05 NA NA NA hsa-miR-192-5p POU2F2 -0.50188499512787 0.00344713341196035 -1.33751623202634 1.7771030308953e-11 mirMAP -0.341125656110109 1.96291965964719e-09 NA NA NA hsa-miR-92a-1-5p PPARA 0.389443191151075 0.0644925359204601 -0.607171871846345 3.30592576448713e-05 mirMAP -0.1302637911527 0.000129305345771016 NA NA NA hsa-miR-148a-3p PPARD -0.748702855596996 3.93313343865641e-07 0.429452867716368 0.000219062523065951 mirMAP -0.204207537151173 5.78289748261195e-08 NA NA NA hsa-miR-20a-5p PPARGC1B 0.854326758727003 5.04256669663285e-07 -0.171170839113116 0.38344943912292 miRNATAP -0.209661765880598 0.000151154852807879 NA NA NA hsa-miR-27b-3p PPARGC1B -0.823491817819754 9.20935302746823e-14 -0.171170839113116 0.38344943912292 mirMAP -0.200915831211865 0.0175340269443675 NA NA NA hsa-miR-92a-1-5p PPL 0.389443191151075 0.0644925359204601 -1.28776765005881 1.67755407466823e-08 MirTarget -0.266020140987447 5.98567724592885e-07 NA NA NA hsa-miR-27b-3p PPM1G -0.823491817819754 9.20935302746823e-14 0.574348560632392 2.1822247920007e-15 miRNATAP -0.163300387984826 2.75773895222118e-07 NA NA NA hsa-miR-20a-5p PPM1L 0.854326758727003 5.04256669663285e-07 -0.358173274286561 0.0774099414261059 mirMAP -0.311916768203704 3.74774994747641e-08 NA NA NA hsa-miR-27b-3p PPP1CC -0.823491817819754 9.20935302746823e-14 0.49737777455741 2.71927608312891e-12 miRNATAP -0.13676023941215 1.07893706554136e-05 NA NA NA hsa-miR-148a-3p PPP1R12A -0.748702855596996 3.93313343865641e-07 0.0309603223785082 0.720960796133803 MirTarget;miRNATAP -0.102194619282546 0.000270364516263776 NA NA NA hsa-miR-192-5p PPP1R12A -0.50188499512787 0.00344713341196035 0.0309603223785082 0.720960796133803 miRNAWalker2_validate -0.108797826979812 7.21116611846716e-06 NA NA NA hsa-miR-20a-5p PPP1R3B 0.854326758727003 5.04256669663285e-07 -1.91981385054872 2.06614046154102e-21 MirTarget;miRNATAP -0.193609975216155 0.00128607596500601 NA NA NA hsa-miR-192-5p PPP1R3D -0.50188499512787 0.00344713341196035 -0.0770264679450831 0.62630578081029 MirTarget;miRNATAP -0.196047609762349 1.0181434476316e-05 NA NA NA hsa-miR-148a-3p PPP1R9A -0.748702855596996 3.93313343865641e-07 -0.189630957451167 0.529029203320251 MirTarget -0.382420008575662 9.31566121697617e-05 NA NA NA hsa-miR-20a-5p PPP2R2A 0.854326758727003 5.04256669663285e-07 -0.893386744728836 1.42691109729952e-19 MirTarget;miRNATAP -0.124111638240801 1.90528354769801e-05 NA NA NA hsa-miR-192-5p PPP2R2C -0.50188499512787 0.00344713341196035 2.04406049288738 0.000156223168786157 mirMAP -0.907229698394586 2.29871744989232e-09 NA NA NA hsa-miR-20a-5p PPP2R3A 0.854326758727003 5.04256669663285e-07 -0.234918525572345 0.207468150002507 mirMAP -0.126270382385945 0.0167740496803341 NA NA NA hsa-miR-192-5p PPP2R3B -0.50188499512787 0.00344713341196035 1.01219188204876 5.93858615542726e-19 miRNAWalker2_validate -0.108639411524065 0.0012321422143427 NA NA NA hsa-miR-20a-5p PPP3CA 0.854326758727003 5.04256669663285e-07 -0.536165287387848 2.77787023947662e-11 miRNATAP -0.13596145796804 2.84983869383186e-09 NA NA NA hsa-miR-148a-3p PQLC3 -0.748702855596996 3.93313343865641e-07 -0.441550833103361 0.00124871420128405 MirTarget -0.227416925597569 2.92661541481649e-07 NA NA NA hsa-miR-20a-5p PRDM2 0.854326758727003 5.04256669663285e-07 -0.339899736847659 4.69085239503072e-05 miRNATAP -0.111009518622204 2.3953156098993e-06 NA NA NA hsa-miR-192-5p PRDM4 -0.50188499512787 0.00344713341196035 0.265885941113794 0.000114217472510259 miRNAWalker2_validate -0.10288977646582 9.70690120754843e-08 NA NA NA hsa-miR-20a-5p PRELP 0.854326758727003 5.04256669663285e-07 -2.5558653032329 1.87476815966153e-13 mirMAP -0.593531651610012 2.7477033723009e-09 NA NA NA hsa-miR-92a-1-5p PRELP 0.389443191151075 0.0644925359204601 -2.5558653032329 1.87476815966153e-13 mirMAP -0.181908762096974 0.028806177248993 NA NA NA hsa-miR-192-5p PRICKLE1 -0.50188499512787 0.00344713341196035 -1.74028095832004 2.56191738876965e-10 miRNAWalker2_validate -0.647920508976856 3.38291204645263e-17 NA NA NA hsa-miR-148a-3p PRICKLE2 -0.748702855596996 3.93313343865641e-07 -1.36375835552812 1.67599789165395e-08 MirTarget;miRNATAP -0.361824889511995 5.66694348602003e-06 NA NA NA hsa-miR-20a-5p PRKAR2A 0.854326758727003 5.04256669663285e-07 -0.445956894636509 0.039701655854281 mirMAP -0.144423440498608 0.0189487099139109 NA NA NA hsa-miR-194-5p PRKCB -0.292530160992458 0.0996141384876663 -1.62067363753233 3.76201992658756e-13 miRNATAP -0.310861421038956 6.51903986219064e-07 NA NA NA hsa-miR-23b-3p PRKCB -0.530561587109023 5.43807206823652e-07 -1.62067363753233 3.76201992658756e-13 mirMAP -0.286204121948097 0.00657996649038471 NA NA NA hsa-miR-30d-5p PRKCB 0.718283816348023 2.47422074061352e-08 -1.62067363753233 3.76201992658756e-13 mirMAP -0.362125630736335 2.22146697946039e-05 NA NA NA hsa-miR-340-5p PRKCB -0.00477614531381576 0.968502722773791 -1.62067363753233 3.76201992658756e-13 mirMAP -0.225497683155663 0.0158024495898231 NA NA NA hsa-miR-361-5p PRKCB 0.233202959858696 0.00961572812255327 -1.62067363753233 3.76201992658756e-13 MirTarget;miRanda;miRNATAP -0.424918272347972 0.000711090604030861 NA NA NA hsa-miR-589-3p PRKCB 1.16846704028095 5.88525574424201e-11 -1.62067363753233 3.76201992658756e-13 mirMAP -0.228692909978861 0.000252673885842927 NA NA NA hsa-miR-589-5p PRKCB 1.18593770505086 1.01781241960531e-22 -1.62067363753233 3.76201992658756e-13 mirMAP -0.552773953594914 1.64276000301029e-10 NA NA NA hsa-miR-616-5p PRKCB 0.150569904638223 0.402836556304524 -1.62067363753233 3.76201992658756e-13 mirMAP -0.245704989615516 7.89898683278172e-05 NA NA NA hsa-miR-664a-3p PRKCB 0.485807855553031 0.000732553249798598 -1.62067363753233 3.76201992658756e-13 mirMAP -0.348212449855556 6.35284546408206e-06 NA NA NA hsa-miR-27b-3p PRKCD -0.823491817819754 9.20935302746823e-14 0.661163999475378 2.10919242029348e-07 miRNATAP -0.145306305033983 0.00898991443202175 NA NA NA hsa-miR-192-5p PRKG1 -0.50188499512787 0.00344713341196035 -1.38853534989461 1.21422425786253e-07 miRNATAP -0.363364288156679 1.18927836843635e-06 NA NA NA hsa-miR-148a-3p PRKX -0.748702855596996 3.93313343865641e-07 -0.240211607134995 0.240371070351319 MirTarget -0.590431480469924 2.08013051455884e-20 NA NA NA hsa-miR-148a-3p PRNP -0.748702855596996 3.93313343865641e-07 -1.31457732397415 1.33903555838973e-11 miRNAWalker2_validate;MirTarget -0.397460387082465 5.03565447558832e-10 NA NA NA hsa-miR-192-5p PRNP -0.50188499512787 0.00344713341196035 -1.31457732397415 1.33903555838973e-11 miRNAWalker2_validate -0.341623379550827 7.41265782181979e-10 NA NA NA hsa-miR-20a-5p PROX1 0.854326758727003 5.04256669663285e-07 -1.50692887128896 6.55353144337011e-08 mirMAP -0.208543678262212 0.00942086750821076 NA NA NA hsa-miR-148a-3p PRR15 -0.748702855596996 3.93313343865641e-07 0.490966715538301 0.252618237144631 MirTarget -0.37711038705465 0.00714647584683602 NA NA NA hsa-miR-20a-5p PRR15 0.854326758727003 5.04256669663285e-07 0.490966715538301 0.252618237144631 MirTarget;miRNATAP -0.385613761194822 0.00148467680487152 NA NA NA hsa-miR-27b-3p PRR16 -0.823491817819754 9.20935302746823e-14 0.998430301852498 2.32891081406947e-06 MirTarget -0.298346958357085 0.00117921722863416 NA NA NA hsa-miR-20a-5p PRRG1 0.854326758727003 5.04256669663285e-07 -0.908192707084856 3.41333706973093e-12 MirTarget;miRNATAP -0.379972582979808 1.55743256143634e-26 NA NA NA hsa-miR-192-5p PRSS23 -0.50188499512787 0.00344713341196035 -0.308894863963872 0.0807584384856214 miRNAWalker2_validate -0.405857208642736 4.31384004876541e-17 NA NA NA hsa-miR-27b-3p PRX -0.823491817819754 9.20935302746823e-14 0.973700085344309 4.95602829998367e-13 miRNATAP -0.123045728858212 0.0396745642493614 NA NA NA hsa-miR-20a-5p PSD3 0.854326758727003 5.04256669663285e-07 -1.20252145080477 1.19868322011977e-09 miRNAWalker2_validate -0.222849941727187 8.97636973532176e-05 NA NA NA hsa-miR-27b-3p PSMA1 -0.823491817819754 9.20935302746823e-14 0.237565655931445 4.93421992716562e-05 MirTarget -0.118656229357411 1.96143450937939e-06 NA NA NA hsa-miR-192-5p PSMC3IP -0.50188499512787 0.00344713341196035 2.9342125654124 3.69090301103456e-32 miRNAWalker2_validate -0.2704228562381 0.000377197692451599 NA NA NA hsa-miR-192-5p PSRC1 -0.50188499512787 0.00344713341196035 1.87705568740869 1.48800397430135e-21 miRNAWalker2_validate -0.11621911267529 0.0483972413932611 NA NA NA hsa-miR-192-5p PTBP2 -0.50188499512787 0.00344713341196035 0.469748381960924 7.20177143528794e-06 miRNAWalker2_validate -0.118453910975341 6.86134286027003e-05 NA NA NA hsa-miR-20a-5p PTGFRN 0.854326758727003 5.04256669663285e-07 0.507316306007716 0.00273384618681765 MirTarget;miRNATAP -0.18065095898388 0.000163701302124096 NA NA NA hsa-miR-27b-3p PTGFRN -0.823491817819754 9.20935302746823e-14 0.507316306007716 0.00273384618681765 MirTarget -0.325423895170273 7.44333339912034e-06 NA NA NA hsa-miR-20a-5p PTK2B 0.854326758727003 5.04256669663285e-07 -0.700590373264672 3.98424408987687e-08 mirMAP -0.126201135304202 0.000561193767707289 NA NA NA hsa-miR-192-5p PTP4A3 -0.50188499512787 0.00344713341196035 1.98288212330108 7.95134226476913e-18 miRNAWalker2_validate -0.393838101836757 4.31264740267398e-09 NA NA NA hsa-miR-148a-3p PTPN14 -0.748702855596996 3.93313343865641e-07 0.635943426312836 0.000736881269593778 MirTarget;miRNATAP -0.430598688156951 9.08169553450041e-13 NA NA NA hsa-miR-27b-3p PTPN14 -0.823491817819754 9.20935302746823e-14 0.635943426312836 0.000736881269593778 mirMAP -0.181913956809451 0.0259456455872694 NA NA NA hsa-miR-20a-5p PTPN4 0.854326758727003 5.04256669663285e-07 -0.276283887533269 0.00146605292632864 miRNATAP -0.139494556721343 8.61866201678084e-09 NA NA NA hsa-miR-20a-5p PTPRD 0.854326758727003 5.04256669663285e-07 -2.42193981889629 1.33671056298661e-09 miRNATAP -0.578847888078726 4.0858725271912e-07 NA NA NA hsa-miR-192-5p PTPRE -0.50188499512787 0.00344713341196035 -0.302082448360899 0.0921369971160767 miRNAWalker2_validate -0.464635712302489 7.26899889346159e-22 NA NA NA hsa-miR-148a-3p PTPRM -0.748702855596996 3.93313343865641e-07 0.0121830472151929 0.941670599603893 miRNATAP -0.257137605577313 1.74355883677486e-06 NA NA NA hsa-miR-20a-5p PTPRO 0.854326758727003 5.04256669663285e-07 -0.996319312073661 7.79820271688871e-06 miRNATAP -0.199817582784959 0.00170645067303651 NA NA NA hsa-miR-20a-5p PTPRS 0.854326758727003 5.04256669663285e-07 -2.31690961469515 2.64772737951824e-10 miRNAWalker2_validate -0.268396673286502 0.0115891346482372 NA NA NA hsa-miR-20a-5p PTRF 0.854326758727003 5.04256669663285e-07 0.145511639550823 0.264171131706134 mirMAP -0.227506046545491 3.05076642288136e-10 NA NA NA hsa-miR-192-5p PXDN -0.50188499512787 0.00344713341196035 -0.804786342551695 2.16750749800913e-06 miRNAWalker2_validate -0.352969347724555 8.82059106206006e-14 NA NA NA hsa-miR-20a-5p PXDN 0.854326758727003 5.04256669663285e-07 -0.804786342551695 2.16750749800913e-06 MirTarget -0.265143082102066 3.33210281270668e-08 NA NA NA hsa-miR-192-5p QSOX1 -0.50188499512787 0.00344713341196035 -0.998176284579899 0.000345773632396881 mirMAP -0.556359066488718 7.12939650913052e-13 NA NA NA hsa-miR-148a-3p RAB10 -0.748702855596996 3.93313343865641e-07 0.283852356286084 7.31286137720053e-05 miRNAWalker2_validate -0.101607342652178 1.24328558037831e-05 NA NA NA hsa-miR-20a-5p RAB11FIP5 0.854326758727003 5.04256669663285e-07 0.00512755246580143 0.969958157879948 MirTarget -0.135236885140177 0.000420517251326306 NA NA NA hsa-miR-192-5p RAB23 -0.50188499512787 0.00344713341196035 0.527982849286996 2.90025934855642e-07 miRNAWalker2_validate -0.15913992868139 4.61556135952921e-08 NA NA NA hsa-miR-192-5p RAB27B -0.50188499512787 0.00344713341196035 -0.982992130812183 0.00316826721508081 MirTarget -0.268391347828475 0.00462724907433718 NA NA NA hsa-miR-20a-5p RAB30 0.854326758727003 5.04256669663285e-07 -0.688840167280648 5.94886883391515e-06 mirMAP;miRNATAP -0.235096722416388 4.36557436475802e-08 NA NA NA hsa-miR-148a-3p RAB34 -0.748702855596996 3.93313343865641e-07 0.412870987704762 0.126202873299987 miRNAWalker2_validate;MirTarget;miRNATAP -0.797089078971911 2.39755456296972e-21 NA NA NA hsa-miR-148a-3p RAB35 -0.748702855596996 3.93313343865641e-07 0.223741416752273 0.000176271000804346 miRNATAP -0.103218271982733 7.43644180741036e-08 NA NA NA hsa-miR-27b-3p RAB3B -0.823491817819754 9.20935302746823e-14 2.31148128583348 9.51479131264821e-10 miRNAWalker2_validate -0.656563986473433 7.22157614610585e-05 NA NA NA hsa-miR-148a-3p RAB6B -0.748702855596996 3.93313343865641e-07 1.14011669130437 2.23537791600293e-14 mirMAP -0.580164632188529 3.02823853653868e-36 NA NA NA hsa-miR-20a-5p RAB8B 0.854326758727003 5.04256669663285e-07 -0.221321521910201 0.0455526239538757 miRNATAP -0.114857641117294 0.000231473698986588 NA NA NA hsa-miR-192-5p RACGAP1 -0.50188499512787 0.00344713341196035 2.47619748809122 3.80949763818893e-47 miRNAWalker2_validate -0.138545140214855 0.0114048690297015 NA NA NA hsa-miR-192-5p RAD51 -0.50188499512787 0.00344713341196035 2.44239687577714 3.5869762404792e-29 miRNAWalker2_validate -0.23074588667787 0.000486619447404882 NA NA NA hsa-miR-192-5p RAD54B -0.50188499512787 0.00344713341196035 1.72250911173302 8.3954343136252e-30 miRNAWalker2_validate -0.137500588773377 0.00295771914695639 NA NA NA hsa-miR-192-5p RADIL -0.50188499512787 0.00344713341196035 0.126144548325969 0.541753255795591 miRNAWalker2_validate -0.372271575053115 8.32754240117811e-11 NA NA NA hsa-miR-20a-5p RAG1 0.854326758727003 5.04256669663285e-07 -1.83334993331865 5.88133623260973e-11 mirMAP -0.453043947075455 1.54036134393619e-08 NA NA NA hsa-miR-27b-3p RALA -0.823491817819754 9.20935302746823e-14 0.356889705448643 1.15054362861669e-08 miRNATAP -0.128080206262242 1.99992119450621e-06 NA NA NA hsa-miR-192-5p RALB -0.50188499512787 0.00344713341196035 -0.133157006154685 0.074563715411608 MirTarget -0.149704404771039 2.69040263284912e-13 NA NA NA hsa-miR-19b-1-5p RALBP1 -0.277804782598538 0.0783067794722916 0.1698024329452 0.0449773531520714 mirMAP -0.107718420080393 3.35490340732313e-05 NA NA NA hsa-miR-148a-3p RALGPS1 -0.748702855596996 3.93313343865641e-07 0.376167916836608 0.081230746695397 mirMAP -0.16344418084918 0.0205836280387605 NA NA NA hsa-miR-20a-5p RANBP10 0.854326758727003 5.04256669663285e-07 -0.164752457150059 0.142653302199525 mirMAP -0.12442572190602 8.25010664355178e-05 NA NA NA hsa-miR-148a-3p RANGAP1 -0.748702855596996 3.93313343865641e-07 0.368298574723631 0.00096323372819063 MirTarget -0.276509616318188 5.75616246983203e-15 NA NA NA hsa-miR-20a-5p RAP2C 0.854326758727003 5.04256669663285e-07 -0.410431451936733 9.12222531349358e-05 MirTarget;miRNATAP -0.126263809564664 2.08756964298057e-05 NA NA NA hsa-miR-20a-5p RAPGEF2 0.854326758727003 5.04256669663285e-07 -0.707388543717723 1.66316838166028e-08 MirTarget;miRNATAP -0.209073810761206 3.83769964779062e-09 NA NA NA hsa-miR-146b-5p RARA 0.419719546795449 0.0457375823220155 0.26381183745838 0.00504882339445867 miRanda -0.113842988881595 1.2506902289011e-07 NA NA NA hsa-miR-20a-5p RARB 0.854326758727003 5.04256669663285e-07 -1.31143497176009 3.56699995885221e-11 miRNATAP -0.321109319269754 1.43912137729233e-08 NA NA NA hsa-miR-20a-5p RASD1 0.854326758727003 5.04256669663285e-07 -1.80141635813111 2.33478853508858e-09 MirTarget -0.344283302448969 7.1988869539664e-05 NA NA NA hsa-miR-20a-5p RASGEF1B 0.854326758727003 5.04256669663285e-07 -2.40154618069155 1.29739869332177e-25 mirMAP -0.414444961508052 1.10248244442407e-09 NA NA NA hsa-miR-148a-3p RASGRP1 -0.748702855596996 3.93313343865641e-07 -0.453717444218552 0.0529724316830882 MirTarget -0.453369512761064 1.78337663608658e-09 NA NA NA hsa-miR-20a-5p RASL11B 0.854326758727003 5.04256669663285e-07 -1.43422303010254 2.46646129541877e-05 MirTarget;miRNATAP -0.312615395724908 0.00127966080512951 NA NA NA hsa-miR-20a-5p RASSF2 0.854326758727003 5.04256669663285e-07 -0.691373209584495 1.83971460491871e-05 MirTarget;miRNATAP -0.17826863778782 0.000103234837686686 NA NA NA hsa-miR-107 RASSF5 0.241662461253461 0.0170788899505389 -0.908227788377981 1.02390034106228e-08 PITA;miRanda;miRNATAP -0.284285927003021 0.000267803442305389 NA NA NA hsa-miR-421 RASSF5 0.941856334694081 6.12167297054077e-08 -0.908227788377981 1.02390034106228e-08 miRanda -0.134754778124398 0.00257128215281031 NA NA NA hsa-miR-532-5p RASSF5 1.02729546510601 9.93318913966636e-16 -0.908227788377981 1.02390034106228e-08 PITA;miRNATAP -0.217078156594971 0.000253741557038178 NA NA NA hsa-miR-20a-5p RASSF6 0.854326758727003 5.04256669663285e-07 -0.748768474661194 0.0102981957577591 mirMAP -0.416341562516064 3.8189794404351e-07 NA NA NA hsa-miR-148a-3p RASSF8 -0.748702855596996 3.93313343865641e-07 -0.720252468942172 0.000203633435082961 miRNAWalker2_validate;miRNATAP -0.252322899887963 6.96701184447254e-05 NA NA NA hsa-miR-192-5p RASSF8 -0.50188499512787 0.00344713341196035 -0.720252468942172 0.000203633435082961 miRNAWalker2_validate -0.294655537239289 6.82278712632995e-08 NA NA NA hsa-miR-20a-5p RB1 0.854326758727003 5.04256669663285e-07 -0.431695598029404 0.00179279020523563 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.144090309816489 0.000231958406673791 NA NA NA hsa-miR-20a-5p RBL2 0.854326758727003 5.04256669663285e-07 -0.988381422306337 9.82564074336519e-12 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.264295882999639 1.60446558088321e-10 NA NA NA hsa-miR-20a-5p RBM43 0.854326758727003 5.04256669663285e-07 -0.466315768538577 0.00138975704061247 mirMAP -0.16769049292253 4.78652474282639e-05 NA NA NA hsa-miR-20a-5p RBM7 0.854326758727003 5.04256669663285e-07 -0.951426616863678 1.80594560797444e-23 mirMAP -0.119535189549173 2.42476541079713e-05 NA NA NA hsa-miR-192-5p RBMS3 -0.50188499512787 0.00344713341196035 -1.89502188938102 2.39783861807597e-18 MirTarget -0.283492807663954 8.66770286802988e-06 NA NA NA hsa-miR-192-5p RCC2 -0.50188499512787 0.00344713341196035 0.694107774930846 9.98545852945955e-11 miRNAWalker2_validate -0.255103081716065 1.39339507760653e-17 NA NA NA hsa-miR-192-5p RECQL -0.50188499512787 0.00344713341196035 0.461343766657584 8.30631534771756e-05 miRNAWalker2_validate -0.125629153287564 0.000160430200995184 NA NA NA hsa-miR-20a-5p REEP3 0.854326758727003 5.04256669663285e-07 -0.539596553642068 2.34780145658624e-10 MirTarget;miRNATAP -0.123952193150281 3.34411039094693e-07 NA NA NA hsa-miR-20a-5p RELL1 0.854326758727003 5.04256669663285e-07 -0.141810188353169 0.221641911979925 MirTarget -0.105618408555217 0.0012477323792959 NA NA NA hsa-miR-20a-5p REPS2 0.854326758727003 5.04256669663285e-07 -1.10574349357584 1.56638093233755e-10 miRNATAP -0.304202385643636 6.00758972605193e-10 NA NA NA hsa-miR-20a-5p REST 0.854326758727003 5.04256669663285e-07 -1.00246189990012 0.000168942614777061 MirTarget;miRNATAP -0.205623360970824 0.00684826539877944 NA NA NA hsa-miR-20a-5p REV3L 0.854326758727003 5.04256669663285e-07 -0.483702621543161 0.000164111273212257 miRNATAP -0.10999882645294 0.00259498316118163 NA NA NA hsa-miR-192-5p RFWD3 -0.50188499512787 0.00344713341196035 0.435632342748586 1.3132101658858e-06 miRNAWalker2_validate -0.111367387435235 1.32685837373949e-05 NA NA NA hsa-miR-20a-5p RGL1 0.854326758727003 5.04256669663285e-07 -0.973948619416663 1.26483337600823e-11 MirTarget;miRNATAP -0.370894710581805 1.31087181871098e-20 NA NA NA hsa-miR-27b-3p RGL2 -0.823491817819754 9.20935302746823e-14 0.662505393800065 9.47215024955331e-11 miRNATAP -0.120382501135317 0.00747149937726321 NA NA NA hsa-miR-148a-3p RGMA -0.748702855596996 3.93313343865641e-07 1.61034636670118 7.04556214896046e-13 miRNATAP -0.400326990300846 7.66740132539719e-08 NA NA NA hsa-miR-192-5p RHBDL3 -0.50188499512787 0.00344713341196035 1.4613952794321 0.000215161782120482 mirMAP -0.259658295704621 0.0214388955940487 NA NA NA hsa-miR-27b-3p RHOBTB1 -0.823491817819754 9.20935302746823e-14 -0.137296947172223 0.622702437970867 miRNATAP -0.457174181238675 0.000131385941935215 NA NA NA hsa-miR-20a-5p RHOC 0.854326758727003 5.04256669663285e-07 0.547331579271749 6.06551674902971e-07 MirTarget;miRNATAP -0.123066154140941 8.29242129116106e-05 NA NA NA hsa-miR-192-5p RIC8B -0.50188499512787 0.00344713341196035 0.0633242659452633 0.517717652069902 miRNAWalker2_validate;MirTarget -0.115537585517966 2.57512233984628e-05 NA NA NA hsa-miR-192-5p RIMKLA -0.50188499512787 0.00344713341196035 -0.0467149849825641 0.857277532379306 miRNAWalker2_validate -0.378132261073007 1.96123417592123e-07 NA NA NA hsa-miR-20a-5p RLIM 0.854326758727003 5.04256669663285e-07 -0.238618585783741 0.00274903628212624 MirTarget -0.107041090463252 1.64746466200643e-06 NA NA NA hsa-miR-20a-5p RNASEL 0.854326758727003 5.04256669663285e-07 -0.297651918005738 0.0884553326716658 MirTarget -0.384301464046521 9.44852630084857e-16 NA NA NA hsa-miR-20a-5p RNF128 0.854326758727003 5.04256669663285e-07 -0.731583017031184 9.18291340209668e-08 MirTarget;miRNATAP -0.18441988180697 2.25872693408926e-06 NA NA NA hsa-miR-27b-3p RNF144A -0.823491817819754 9.20935302746823e-14 0.810171087466595 2.5048912384854e-06 MirTarget;miRNATAP -0.321043758510163 1.62455799730643e-05 NA NA NA hsa-miR-20a-5p RNF165 0.854326758727003 5.04256669663285e-07 -3.06109685929762 4.74971186974903e-22 mirMAP -0.319694617444346 0.000720178924944203 NA NA NA hsa-miR-27b-3p RNF207 -0.823491817819754 9.20935302746823e-14 0.828705825765608 2.83913644606982e-10 miRNATAP -0.260027058787256 5.74935663313936e-06 NA NA NA hsa-miR-27b-3p RNF24 -0.823491817819754 9.20935302746823e-14 1.10714531329534 8.18323484435844e-11 mirMAP -0.409713529474916 3.19620219118214e-08 NA NA NA hsa-miR-148a-3p RNF44 -0.748702855596996 3.93313343865641e-07 0.663587868143992 1.70848468031349e-11 miRNATAP -0.205949484265224 1.81870928982656e-10 NA NA NA hsa-miR-20a-5p RNH1 0.854326758727003 5.04256669663285e-07 0.0423956504637601 0.606057902948997 miRNATAP -0.137925378303679 1.32340045810629e-09 NA NA NA hsa-miR-148a-3p ROBO1 -0.748702855596996 3.93313343865641e-07 2.32143722202073 1.044638687882e-16 MirTarget;miRNATAP -0.420616800754574 8.25510016639746e-06 NA NA NA hsa-miR-148a-3p ROBO2 -0.748702855596996 3.93313343865641e-07 -1.20081293982521 0.00234813022306189 miRNATAP -0.266203176462404 0.0402513644855282 NA NA NA hsa-miR-92a-1-5p ROBO4 0.389443191151075 0.0644925359204601 -0.113841461867362 0.426767073353492 MirTarget -0.10313565441296 0.00183144512068 NA NA NA hsa-miR-324-5p ROCK1 0.372933276649782 0.00592280066108904 -0.264366618624451 0.00575875249305368 MirTarget;PITA;miRanda -0.132464043588386 0.000113488217308036 NA NA NA hsa-miR-17-5p ROCK2 0.698861147045461 2.43854106455398e-05 -0.343723141838983 0.0978147147700846 TargetScan -0.230848684676223 0.000132737616833034 NA NA NA hsa-miR-27b-3p ROR1 -0.823491817819754 9.20935302746823e-14 -0.491754583860676 0.154312136980948 MirTarget;miRNATAP -0.469646389829807 0.00156411878262893 26576539 Bioinformatic prediction luciferase reporter assay quantitative real-time PCR qRT-PCR and western blotting were used to reveal the regulatory relationship between miR-27b-3p and ROR1; The expression patterns of miR-27b-3p and ROR1 in human gastric cancer GC specimens and cell lines were determined by microRNA RT-PCR and western blotting; miR-27b-3p suppressed ROR1 expression by binding to the 3'UTR of ROR1 mRNA in GC cells; miR-27b-3p was significantly downregulated and reversely correlated with ROR1 protein levels in clinical samples; Analysis of the clinicopathological significance showed that miR-27b-3p and ROR1 were closely correlated with GC characteristics; These results show that miR-27b-3p suppresses ROR1 expression through the binding site in the 3'UTR inhibiting the cell proliferation; These findings indicate that miR-27b-3p exerts tumor-suppressive effects in GC through the suppression of oncogene ROR1 expression and suggest a therapeutic application of miR-27b-3p in GC gastric cancer hsa-miR-20a-5p RORA 0.854326758727003 5.04256669663285e-07 -1.18591701647076 1.08163415927424e-11 MirTarget;miRNATAP -0.274250331473419 4.20968585910911e-08 NA NA NA hsa-miR-192-5p RPGRIP1L -0.50188499512787 0.00344713341196035 0.672861725371994 2.95668883160042e-07 miRNAWalker2_validate -0.29949373136012 1.76626747021087e-16 NA NA NA hsa-miR-27b-3p RPGRIP1L -0.823491817819754 9.20935302746823e-14 0.672861725371994 2.95668883160042e-07 MirTarget;miRNATAP -0.181986506407573 0.00145788753392262 NA NA NA hsa-miR-27b-3p RPN2 -0.823491817819754 9.20935302746823e-14 0.474714258889196 1.36911430658968e-11 miRNATAP -0.154968262295887 3.7245765251133e-07 NA NA NA hsa-miR-20a-5p RPS6KA1 0.854326758727003 5.04256669663285e-07 -0.0193982843076919 0.895272926505225 miRNATAP -0.140420093444226 0.000724052018701145 NA NA NA hsa-miR-20a-5p RPS6KA5 0.854326758727003 5.04256669663285e-07 -0.827283685514513 1.58444228442933e-05 MirTarget -0.133604221805227 0.0148516181805604 NA NA NA hsa-miR-27b-3p RPTOR -0.823491817819754 9.20935302746823e-14 0.681970822272688 1.01116104311691e-17 miRNAWalker2_validate -0.116093691653188 0.001071699641235 NA NA NA hsa-miR-192-5p RUNX1 -0.50188499512787 0.00344713341196035 -0.00485952026487979 0.975956818735336 mirMAP;miRNATAP -0.313304951639482 1.86103486307586e-12 NA NA NA hsa-miR-148a-3p RUNX2 -0.748702855596996 3.93313343865641e-07 -0.630390083285145 0.00682374266364812 miRNATAP -0.611751537093558 9.56180468519476e-17 NA NA NA hsa-miR-192-5p RUNX3 -0.50188499512787 0.00344713341196035 -1.01114722675633 2.35128238262054e-07 mirMAP -0.320525727272112 7.0875310616877e-09 NA NA NA hsa-miR-20a-5p RUNX3 0.854326758727003 5.04256669663285e-07 -1.01114722675633 2.35128238262054e-07 MirTarget -0.142575383323139 0.0112321596436001 27748919 MicroRNA 20a 5p targets RUNX3 to regulate proliferation and migration of human hepatocellular cancer cells; Further studies revealed RUNX3 an important tumor-suppressor as a direct target of miR-20a-5p; Collectively our results support the viewpoint that miR-20-5p has an oncogenic property miR-20a overexpression contributed to HCC cell proliferation and migration through reducing the translation of RUNX3; The data provide a new mechanism of miR-20a regulating RUNX3 in HCC liver cancer hsa-miR-20a-5p S1PR1 0.854326758727003 5.04256669663285e-07 -0.723869489322336 1.31811287279409e-06 MirTarget;miRNATAP -0.156524671817097 0.000249116225567984 NA NA NA hsa-miR-148a-3p SACS -0.748702855596996 3.93313343865641e-07 0.236568458255628 0.160647331666559 MirTarget -0.235342582834692 1.67486040913103e-05 NA NA NA hsa-miR-27b-3p SAMD10 -0.823491817819754 9.20935302746823e-14 0.872932422756584 1.87788574518353e-13 miRNATAP -0.226323562537202 1.47791099197243e-05 NA NA NA hsa-miR-20a-5p SAMD12 0.854326758727003 5.04256669663285e-07 -2.38933684023892 1.51021075610838e-11 miRNATAP -0.2858665945878 0.00548109075773982 NA NA NA hsa-miR-192-5p SAMD13 -0.50188499512787 0.00344713341196035 0.350362895121864 0.130706227613663 miRNAWalker2_validate -0.19925279594921 0.00239887256233847 NA NA NA hsa-miR-192-5p SAMD3 -0.50188499512787 0.00344713341196035 -0.65807084601691 0.00282704939406572 miRNAWalker2_validate -0.290151789940621 3.0567412640441e-06 NA NA NA hsa-miR-20a-5p SAMD5 0.854326758727003 5.04256669663285e-07 -3.18008032786867 6.30217447905566e-16 mirMAP -0.288636115784874 0.012672633787844 NA NA NA hsa-miR-20a-5p SAMHD1 0.854326758727003 5.04256669663285e-07 -0.219855252528804 0.21059107396466 mirMAP -0.203285313284581 3.88734666921236e-05 NA NA NA hsa-miR-20a-5p SAR1B 0.854326758727003 5.04256669663285e-07 -0.602691569549908 4.60715859176311e-06 MirTarget;miRNATAP -0.128999389744833 0.000585913519230086 NA NA NA hsa-miR-20a-5p SASH1 0.854326758727003 5.04256669663285e-07 -0.641621637334084 3.36245859697969e-07 MirTarget;miRNATAP -0.184641895216367 2.23399802113957e-07 NA NA NA hsa-miR-27b-3p SCAMP3 -0.823491817819754 9.20935302746823e-14 1.20056451579604 1.63329457117019e-29 miRNATAP -0.256428735108341 1.31537964944869e-07 NA NA NA hsa-miR-192-5p SCMH1 -0.50188499512787 0.00344713341196035 0.430990022267255 9.70332644759149e-06 miRNAWalker2_validate -0.141555074158591 2.62835175056788e-07 NA NA NA hsa-miR-20a-5p SCN1B 0.854326758727003 5.04256669663285e-07 -0.548658850513823 0.000514941323068981 mirMAP -0.196545604647317 1.07491881096094e-05 NA NA NA hsa-miR-148a-3p SCRN1 -0.748702855596996 3.93313343865641e-07 -0.166351597402062 0.455235320666996 mirMAP -0.565993533684603 7.92544326060182e-16 25399950 A genetic variant of miR 148a binding site in the SCRN1 3' UTR is associated with susceptibility and prognosis of gastric cancer; Using bioinformatics tools we selected two SNPs SCRN1 rs6976789 and PDYN rs2235749 located in miR-148a target sites worse prognosis gastric cancer hsa-miR-192-5p SCRN1 -0.50188499512787 0.00344713341196035 -0.166351597402062 0.455235320666996 mirMAP -0.650406147022789 2.93160025955298e-28 NA NA NA hsa-miR-192-5p SDC3 -0.50188499512787 0.00344713341196035 -0.897187533041453 1.4466200652116e-09 mirMAP -0.350631196480947 1.86371720007883e-17 NA NA NA hsa-miR-20a-5p SDCBP 0.854326758727003 5.04256669663285e-07 0.10062853278239 0.394470981999639 miRNATAP -0.189267199459337 8.47524331761686e-09 NA NA NA hsa-miR-148a-3p SDK2 -0.748702855596996 3.93313343865641e-07 -0.809681459593403 0.027508642080261 mirMAP -0.283099945212776 0.018670514896433 NA NA NA hsa-miR-20a-5p SEMA4B 0.854326758727003 5.04256669663285e-07 -0.60655833810578 2.90170864411715e-06 MirTarget -0.161536541763846 1.16281515939978e-05 NA NA NA hsa-miR-192-5p SEMA4D -0.50188499512787 0.00344713341196035 -0.485873273807039 0.0091347781226638 miRNAWalker2_validate -0.377262402597977 2.41600999211413e-13 NA NA NA hsa-miR-20a-5p SEMA6A 0.854326758727003 5.04256669663285e-07 -1.01308253607629 9.68055629258042e-05 mirMAP -0.150178925515583 0.0433463436385315 NA NA NA hsa-miR-20a-5p SEMA7A 0.854326758727003 5.04256669663285e-07 1.19314988680133 1.05996526123706e-06 MirTarget;miRNATAP -0.141546898688235 0.0440315622619618 NA NA NA hsa-miR-27b-3p SEMA7A -0.823491817819754 9.20935302746823e-14 1.19314988680133 1.05996526123706e-06 MirTarget;miRNATAP -0.46815610817365 9.84838265036026e-06 NA NA NA hsa-miR-148a-3p SEPT9 -0.748702855596996 3.93313343865641e-07 0.491611991206742 1.43369490340499e-09 mirMAP -0.217299710958597 5.96744758598083e-17 NA NA NA hsa-miR-148a-3p SERPINE1 -0.748702855596996 3.93313343865641e-07 -2.5626204615753 1.45202766560285e-19 miRNATAP -0.208585842910118 0.0317546494376279 NA NA NA hsa-miR-20a-5p SESN3 0.854326758727003 5.04256669663285e-07 -0.821541570789657 0.00383798636487833 MirTarget -0.40024159648166 5.55264508290224e-07 NA NA NA hsa-miR-148a-3p SESTD1 -0.748702855596996 3.93313343865641e-07 0.726908919315734 4.26585328930009e-09 miRNAWalker2_validate;MirTarget;miRNATAP -0.109379528086166 0.00785482875672258 NA NA NA hsa-miR-192-5p SETD4 -0.50188499512787 0.00344713341196035 0.822795103734063 1.19357180170398e-22 miRNAWalker2_validate -0.116180063788143 2.89418575414034e-06 NA NA NA hsa-miR-20a-5p SETD7 0.854326758727003 5.04256669663285e-07 -0.645690628283917 3.04188071973992e-07 mirMAP -0.234270603961015 3.61885872394216e-11 NA NA NA hsa-miR-20a-5p SFXN1 0.854326758727003 5.04256669663285e-07 -0.990318290801911 5.86324585320089e-17 mirMAP -0.143191583848751 3.53525790156213e-05 NA NA NA hsa-miR-192-5p SGCB -0.50188499512787 0.00344713341196035 -0.991863016074027 7.13504872359113e-06 miRNAWalker2_validate -0.154794352463484 0.0145231978761119 NA NA NA hsa-miR-20a-5p SGCD 0.854326758727003 5.04256669663285e-07 -2.19675212080742 3.14480928648648e-10 mirMAP -0.68633576289089 3.5926399780433e-12 NA NA NA hsa-miR-27b-3p SGTB -0.823491817819754 9.20935302746823e-14 0.0810874123995056 0.438106771519805 MirTarget -0.161027975428053 0.000318010100863441 NA NA NA hsa-miR-20a-5p SH2B3 0.854326758727003 5.04256669663285e-07 -0.362619555502857 0.00114081856769928 MirTarget -0.109838156162695 0.000502146107066274 NA NA NA hsa-miR-20a-5p SH3BP5 0.854326758727003 5.04256669663285e-07 -0.719247176940928 1.59549442781556e-06 miRNATAP -0.278297162107647 3.51453217893864e-11 NA NA NA hsa-miR-27b-3p SH3GL3 -0.823491817819754 9.20935302746823e-14 0.563667600337586 0.172947352730134 miRNATAP -0.380394510388594 0.0330889860400037 NA NA NA hsa-miR-20a-5p SH3GLB1 0.854326758727003 5.04256669663285e-07 -0.324993114681338 1.11759082275534e-06 MirTarget -0.139846663138945 3.41550667393548e-14 NA NA NA hsa-miR-192-5p SH3RF3 -0.50188499512787 0.00344713341196035 0.372077452583573 0.136814784242837 MirTarget;miRNATAP -0.576427639323703 3.05022832647926e-17 NA NA NA hsa-miR-148a-3p SHC3 -0.748702855596996 3.93313343865641e-07 1.52510778944018 2.16327808412124e-07 MirTarget -0.266138626489331 0.00635514525014243 NA NA NA hsa-miR-20a-5p SHISA9 0.854326758727003 5.04256669663285e-07 -1.20843414172775 0.000663916656116767 mirMAP -0.352548674263272 0.000473298312175861 NA NA NA hsa-miR-20a-5p SHROOM4 0.854326758727003 5.04256669663285e-07 0.38170789610378 0.0117604023519324 mirMAP -0.15930269229914 0.000198676259188657 NA NA NA hsa-miR-20a-5p SIK1 0.854326758727003 5.04256669663285e-07 -1.56281900212212 2.20390485809155e-13 MirTarget;miRNATAP -0.188334637550677 0.00243717192295782 NA NA NA hsa-miR-20a-5p SIRPA 0.854326758727003 5.04256669663285e-07 -0.71524536340462 3.11665477449842e-07 miRNAWalker2_validate -0.185170761493752 3.23452227601708e-06 NA NA NA hsa-miR-148a-3p SIX4 -0.748702855596996 3.93313343865641e-07 2.61579593202535 2.3706138390953e-15 miRNATAP -0.567991524754382 2.80120759528324e-07 NA NA NA hsa-miR-192-5p SIX4 -0.50188499512787 0.00344713341196035 2.61579593202535 2.3706138390953e-15 miRNAWalker2_validate -0.375289735370248 0.000102213669676659 NA NA NA hsa-miR-27b-3p SKA3 -0.823491817819754 9.20935302746823e-14 3.70437460242013 6.48201535159511e-47 MirTarget -0.618146032186515 5.5003056347753e-07 NA NA NA hsa-miR-20a-5p SLAIN2 0.854326758727003 5.04256669663285e-07 -0.37865756950093 8.79283914288049e-08 MirTarget;miRNATAP -0.143824678103796 2.74641556653432e-13 NA NA NA hsa-miR-148a-3p SLC16A6 -0.748702855596996 3.93313343865641e-07 -0.236488661429015 0.313225012355655 MirTarget;miRNATAP -0.276157865502067 0.00029453291851848 NA NA NA hsa-miR-192-5p SLC16A6 -0.50188499512787 0.00344713341196035 -0.236488661429015 0.313225012355655 miRNAWalker2_validate -0.167554938859513 0.0116923570848654 NA NA NA hsa-miR-192-5p SLC16A7 -0.50188499512787 0.00344713341196035 -1.26418567420408 1.8151156622962e-05 miRNAWalker2_validate -0.25450344115478 0.00254476446577388 NA NA NA hsa-miR-20a-5p SLC1A2 0.854326758727003 5.04256669663285e-07 -2.05184743338733 5.07102901300161e-06 miRNATAP -0.315519514745736 0.0144392641505683 NA NA NA hsa-miR-27b-3p SLC22A23 -0.823491817819754 9.20935302746823e-14 0.632125395741205 5.61389746801226e-07 MirTarget;miRNATAP -0.253238840747903 3.52193146511478e-06 NA NA NA hsa-miR-148a-3p SLC24A3 -0.748702855596996 3.93313343865641e-07 -1.47084747826355 6.82498530848671e-06 MirTarget;miRNATAP -0.89028739568033 1.00504027954793e-17 NA NA NA hsa-miR-20a-5p SLC25A37 0.854326758727003 5.04256669663285e-07 -0.718161877117594 9.11526444419931e-09 mirMAP -0.17315361235863 1.18783290001245e-06 NA NA NA hsa-miR-192-5p SLC26A2 -0.50188499512787 0.00344713341196035 1.09398018681738 4.62078215884211e-18 miRNAWalker2_validate -0.18929295889859 2.86751937479486e-07 NA NA NA hsa-miR-27b-3p SLC26A2 -0.823491817819754 9.20935302746823e-14 1.09398018681738 4.62078215884211e-18 MirTarget;mirMAP -0.217078303758547 0.000120093583037924 NA NA NA hsa-miR-148a-3p SLC2A1 -0.748702855596996 3.93313343865641e-07 0.341472370166429 0.158776644395418 MirTarget;miRNATAP -0.348562751036544 9.14649062361368e-06 NA NA NA hsa-miR-148a-3p SLC2A3 -0.748702855596996 3.93313343865641e-07 -1.04127632515242 1.14147654600336e-07 miRNAWalker2_validate -0.190614379961144 0.00339947195751862 NA NA NA hsa-miR-20a-5p SLC2A3 0.854326758727003 5.04256669663285e-07 -1.04127632515242 1.14147654600336e-07 mirMAP -0.269088228510012 1.50616194401085e-06 NA NA NA hsa-miR-92a-1-5p SLC2A4 0.389443191151075 0.0644925359204601 -0.000620280921127536 0.998114091638356 miRNAWalker2_validate -0.16936697813307 0.00531011002521453 NA NA NA hsa-miR-20a-5p SLC31A1 0.854326758727003 5.04256669663285e-07 -1.14463479413429 2.19129504521951e-22 mirMAP -0.142226517589456 4.62417018819386e-05 NA NA NA hsa-miR-20a-5p SLC35A3 0.854326758727003 5.04256669663285e-07 -0.547853260400994 1.47231547250532e-05 mirMAP -0.116258699262612 0.00125799273414361 NA NA NA hsa-miR-192-5p SLC35F3 -0.50188499512787 0.00344713341196035 -0.462303983641436 0.153172594830782 miRNAWalker2_validate -0.547128220537391 1.28939029625719e-09 NA NA NA hsa-miR-27b-3p SLC36A1 -0.823491817819754 9.20935302746823e-14 1.00108743458475 1.1038952891858e-17 mirMAP -0.327053304705245 1.96588203108573e-10 NA NA NA hsa-miR-20a-5p SLC38A7 0.854326758727003 5.04256669663285e-07 0.104382958953614 0.530198765508847 mirMAP -0.117132603934739 0.0127942532299911 NA NA NA hsa-miR-148a-3p SLC39A13 -0.748702855596996 3.93313343865641e-07 0.702545531021421 5.82346425244418e-19 miRNATAP -0.222800867605752 6.15944021935761e-18 NA NA NA hsa-miR-27b-3p SLC39A13 -0.823491817819754 9.20935302746823e-14 0.702545531021421 5.82346425244418e-19 miRNATAP -0.12980897586579 0.00023476727009572 NA NA NA hsa-miR-20a-5p SLC39A14 0.854326758727003 5.04256669663285e-07 -1.85864021395129 3.32951300990533e-30 mirMAP -0.216461690158133 1.12426641584842e-05 NA NA NA hsa-miR-20a-5p SLC40A1 0.854326758727003 5.04256669663285e-07 -0.732233412510245 1.8108481356758e-08 miRNATAP -0.246179472239857 1.75567207064433e-11 NA NA NA hsa-miR-148a-3p SLC45A4 -0.748702855596996 3.93313343865641e-07 1.20758734416733 6.6417314824029e-07 mirMAP -0.79388527746553 1.02781346364025e-25 NA NA NA hsa-miR-20a-5p SLC46A3 0.854326758727003 5.04256669663285e-07 -2.30736008231442 6.1076171377924e-15 MirTarget -0.627945552818981 9.42496618319929e-14 NA NA NA hsa-miR-20a-5p SLC4A4 0.854326758727003 5.04256669663285e-07 -2.23317622565422 7.81779722860372e-13 MirTarget -0.822836909023111 2.0355655458646e-21 NA NA NA hsa-miR-27b-3p SLC5A6 -0.823491817819754 9.20935302746823e-14 0.197307436899311 0.230852494089565 miRNAWalker2_validate -0.141925936029322 0.0455898319731579 NA NA NA hsa-miR-27b-3p SLC6A6 -0.823491817819754 9.20935302746823e-14 -0.096527667226542 0.716815862195345 miRNATAP -0.454973244535813 6.50136825790604e-05 NA NA NA hsa-miR-192-5p SLC7A1 -0.50188499512787 0.00344713341196035 0.502718713769507 0.0648822874814592 mirMAP -0.603441045872077 6.26149464563179e-16 NA NA NA hsa-miR-148a-3p SLC7A11 -0.748702855596996 3.93313343865641e-07 3.47167805920945 1.56674476751757e-19 miRNATAP -0.536459394778507 4.08618619144432e-05 NA NA NA hsa-miR-192-5p SLC7A11 -0.50188499512787 0.00344713341196035 3.47167805920945 1.56674476751757e-19 miRNAWalker2_validate;mirMAP -0.504382504388114 8.44260569578369e-06 NA NA NA hsa-miR-27b-3p SLC7A11 -0.823491817819754 9.20935302746823e-14 3.47167805920945 1.56674476751757e-19 miRNATAP -1.16619265566671 5.68697337740727e-12 NA NA NA hsa-miR-148a-3p SLC8A1 -0.748702855596996 3.93313343865641e-07 -1.67234164835265 3.98185932744172e-20 MirTarget -0.196962024419765 0.00156195195265746 NA NA NA hsa-miR-192-5p SLCO3A1 -0.50188499512787 0.00344713341196035 0.0319186627851762 0.855727741201124 miRNAWalker2_validate -0.393469014234583 2.23727777917774e-16 NA NA NA hsa-miR-27b-3p SLCO5A1 -0.823491817819754 9.20935302746823e-14 0.673563110902495 0.0153869463632922 MirTarget -0.542278204145694 5.25045832598219e-06 NA NA NA hsa-miR-20a-5p SLFN5 0.854326758727003 5.04256669663285e-07 -0.551587674528743 0.0044566272451042 mirMAP -0.403161741335862 4.97863429587109e-14 NA NA NA hsa-miR-27b-3p SLFN5 -0.823491817819754 9.20935302746823e-14 -0.551587674528743 0.0044566272451042 MirTarget -0.301425496157525 0.000307786052888751 NA NA NA hsa-miR-192-5p SLIT3 -0.50188499512787 0.00344713341196035 0.157466553388729 0.504736595264199 mirMAP -0.470658969765089 4.74981152368516e-13 NA NA NA hsa-miR-20a-5p SLITRK3 0.854326758727003 5.04256669663285e-07 -5.61860150003464 8.77286424520162e-28 miRNATAP -0.344476787536725 0.0275112446726135 NA NA NA hsa-miR-20a-5p SLK 0.854326758727003 5.04256669663285e-07 -0.352886234776743 0.000875676142405013 MirTarget -0.100483399287651 0.000825494029384894 NA NA NA hsa-miR-148a-3p SMAD5 -0.748702855596996 3.93313343865641e-07 0.163025158576987 0.0964365530955469 MirTarget -0.118682964369505 0.000191401765007103 NA NA NA hsa-miR-20a-5p SMAD7 0.854326758727003 5.04256669663285e-07 -0.723856409040082 1.50332971335389e-07 miRNATAP -0.116628969266854 0.00318831344924215 NA NA NA hsa-miR-20a-5p SMAD9 0.854326758727003 5.04256669663285e-07 -1.49767600167527 1.61311444052049e-07 mirMAP -0.324007275940665 7.46808100744451e-05 NA NA NA hsa-miR-148a-3p SMARCD1 -0.748702855596996 3.93313343865641e-07 0.643238619401545 1.43047276243426e-17 miRNATAP -0.179723038421978 4.85357530537153e-13 NA NA NA hsa-miR-181a-5p SMC1A 0.250113435902954 0.0551933249319293 0.0651833474337025 0.510370716253497 mirMAP -0.117542893899761 0.00146146139664929 NA NA NA hsa-miR-181c-5p SMC1A -0.00639394152050299 0.969127212255928 0.0651833474337025 0.510370716253497 mirMAP -0.102787280067137 0.000412049730773496 NA NA NA hsa-miR-193b-3p SMC3 -0.166697207281748 0.272022543069482 0.203644948628179 0.0850721957839735 miRNAWalker2_validate -0.129842117232487 0.000624818169450842 NA NA NA hsa-miR-27b-3p SMCR8 -0.823491817819754 9.20935302746823e-14 0.453242799658724 3.50739679214307e-06 MirTarget -0.113122241716497 0.00769664924976443 NA NA NA hsa-miR-20a-5p SMPD3 0.854326758727003 5.04256669663285e-07 -2.39946548240761 3.072395130044e-30 mirMAP -0.324689002767827 2.98851069807802e-07 NA NA NA hsa-miR-148a-3p SMS -0.748702855596996 3.93313343865641e-07 0.164928667940139 0.0543736469004317 MirTarget;miRNATAP -0.129001086204858 3.12204121587798e-06 NA NA NA hsa-miR-148a-3p SNN -0.748702855596996 3.93313343865641e-07 0.139978056935726 0.1435877993436 MirTarget;miRNATAP -0.188024868908952 7.9924616995449e-10 NA NA NA hsa-miR-27b-3p SNN -0.823491817819754 9.20935302746823e-14 0.139978056935726 0.1435877993436 miRNATAP -0.255878709032127 2.1289737903032e-10 NA NA NA hsa-miR-148a-3p SNPH -0.748702855596996 3.93313343865641e-07 0.669218523436135 0.00151404681785838 mirMAP;miRNATAP -0.61217632083124 2.03479411590929e-20 NA NA NA hsa-miR-148a-3p SNRPD1 -0.748702855596996 3.93313343865641e-07 0.672324466321794 7.13760714023798e-11 MirTarget -0.193675346146832 1.11177175064211e-08 NA NA NA hsa-miR-20a-5p SNTB2 0.854326758727003 5.04256669663285e-07 0.0360555273255536 0.678102231349933 miRNATAP -0.12323767013989 3.53516042068765e-07 NA NA NA hsa-miR-20a-5p SNX12 0.854326758727003 5.04256669663285e-07 0.0904979691922572 0.516171836726953 miRNATAP -0.113338963700175 0.00398916157096421 NA NA NA hsa-miR-192-5p SOAT1 -0.50188499512787 0.00344713341196035 -0.0648381834249045 0.544577902932084 miRNAWalker2_validate -0.103656790977631 0.00058268637465778 NA NA NA hsa-miR-20a-5p SOCS6 0.854326758727003 5.04256669663285e-07 -1.07676840516879 9.71590997834803e-26 miRNATAP -0.120227868735618 9.20661478497345e-05 NA NA NA hsa-miR-20a-5p SORBS2 0.854326758727003 5.04256669663285e-07 -1.05178871500438 1.28000308624213e-08 MirTarget -0.219491129300999 3.43262005500774e-05 NA NA NA hsa-miR-20a-5p SORL1 0.854326758727003 5.04256669663285e-07 -1.76063037333749 3.20297520312196e-18 MirTarget;miRNATAP -0.28072917745071 2.18417619752167e-06 NA NA NA hsa-miR-20a-5p SOS1 0.854326758727003 5.04256669663285e-07 0.05751534180893 0.493041822065916 MirTarget;miRNATAP -0.100063123806167 2.02695724421345e-05 NA NA NA hsa-miR-148a-3p SOX11 -0.748702855596996 3.93313343865641e-07 1.40787252269122 1.13853242912301e-05 miRNATAP -1.07091287526546 4.31008991786723e-27 NA NA NA hsa-miR-27b-3p SOX11 -0.823491817819754 9.20935302746823e-14 1.40787252269122 1.13853242912301e-05 miRNATAP -0.478067565459517 0.000596745384087221 NA NA NA hsa-miR-27b-3p SP6 -0.823491817819754 9.20935302746823e-14 2.23551885984922 1.02825725864058e-20 miRNATAP -0.420559598547192 9.77723698387977e-05 NA NA NA hsa-miR-192-5p SPARC -0.50188499512787 0.00344713341196035 0.718137488173 6.98854384110794e-07 miRNAWalker2_validate -0.376480630141672 1.70979260364267e-21 NA NA NA hsa-miR-92a-1-5p SPNS2 0.389443191151075 0.0644925359204601 -1.01405736215089 3.23650865142939e-06 mirMAP -0.284926188621328 1.51618302317441e-08 NA NA NA hsa-miR-20a-5p SPRED1 0.854326758727003 5.04256669663285e-07 -0.584055575592488 6.88990777515141e-05 miRNATAP -0.165176765151827 7.31830031380624e-05 NA NA NA hsa-miR-192-5p SPRY4 -0.50188499512787 0.00344713341196035 -0.334402157998528 0.0123258475801913 miRNAWalker2_validate -0.12594333673096 0.000869467405159125 NA NA NA hsa-miR-20a-5p SRCIN1 0.854326758727003 5.04256669663285e-07 0.0572903847582404 0.79284156387504 MirTarget -0.156461625478448 0.0112678615010555 NA NA NA hsa-miR-27b-3p SRGAP2 -0.823491817819754 9.20935302746823e-14 0.77156783154035 3.52407714516935e-11 MirTarget -0.248550531210308 1.00887772701706e-06 NA NA NA hsa-miR-20a-5p SRGAP3 0.854326758727003 5.04256669663285e-07 0.271507432908788 0.17260362358842 miRNATAP -0.154099853924408 0.00624812089790598 NA NA NA hsa-miR-27b-3p SRGAP3 -0.823491817819754 9.20935302746823e-14 0.271507432908788 0.17260362358842 miRNATAP -0.239084692378411 0.00526617019551541 NA NA NA hsa-miR-20a-5p SRL 0.854326758727003 5.04256669663285e-07 -0.709345641602721 8.73318839614034e-05 mirMAP -0.17860282416388 0.000517359452459933 NA NA NA hsa-miR-148a-3p SRRM3 -0.748702855596996 3.93313343865641e-07 1.37120942849299 0.000135491162818506 mirMAP -0.705228453146128 1.29888212423459e-09 NA NA NA hsa-miR-148a-3p SSBP2 -0.748702855596996 3.93313343865641e-07 -0.124114637043314 0.588013472488598 MirTarget -0.630106222214928 1.58562698769295e-18 NA NA NA hsa-miR-20a-5p SSX2IP 0.854326758727003 5.04256669663285e-07 0.284146878517911 0.111114755854163 MirTarget;miRNATAP -0.133345184368822 0.00829529021779053 NA NA NA hsa-miR-20a-5p ST6GALNAC3 0.854326758727003 5.04256669663285e-07 -1.04258541098903 2.10396558808448e-09 MirTarget -0.297600391121308 1.71634357155285e-09 NA NA NA hsa-miR-20a-5p ST6GALNAC6 0.854326758727003 5.04256669663285e-07 -0.858012119719114 8.21086038364155e-13 MirTarget;miRNATAP -0.151524329670897 1.2219714559824e-05 NA NA NA hsa-miR-27b-3p ST8SIA1 -0.823491817819754 9.20935302746823e-14 0.303148453883592 0.256284129204521 miRNATAP -0.249800856180043 0.0300737664448183 NA NA NA hsa-miR-30b-5p STAG1 -0.54056186708617 2.44688760798341e-05 -0.178198619776885 0.243967920887864 MirTarget -0.20850853639894 0.00030033116479739 NA NA NA hsa-miR-30d-5p STAG1 0.718283816348023 2.47422074061352e-08 -0.178198619776885 0.243967920887864 MirTarget;mirMAP -0.140033891643882 0.0142456491944109 NA NA NA hsa-miR-20a-5p STAT3 0.854326758727003 5.04256669663285e-07 -0.787818268277734 2.21497977966771e-15 miRNAWalker2_validate;miRNATAP -0.204002628417709 5.95071178568667e-13 NA NA NA hsa-miR-192-5p STIL -0.50188499512787 0.00344713341196035 2.27606240799083 3.73674028972289e-36 miRNAWalker2_validate -0.168612906064759 0.00267011641470547 NA NA NA hsa-miR-192-5p STK17B -0.50188499512787 0.00344713341196035 -0.443052997570354 0.011484300538988 miRNAWalker2_validate -0.326984567808828 1.84309115333926e-11 NA NA NA hsa-miR-148a-3p STK24 -0.748702855596996 3.93313343865641e-07 0.19247054896382 0.0273376591701568 mirMAP -0.171740620181524 7.53809919687189e-10 NA NA NA hsa-miR-27b-3p STK32B -0.823491817819754 9.20935302746823e-14 0.825477729275744 0.000150809942053144 MirTarget -0.214864106788388 0.0231588783641708 NA NA NA hsa-miR-148a-3p STK38L -0.748702855596996 3.93313343865641e-07 -0.426911630799545 7.77556827907282e-05 MirTarget -0.167682651806632 1.85608742152544e-06 NA NA NA hsa-miR-27b-3p STK39 -0.823491817819754 9.20935302746823e-14 1.59540335392395 1.26186756425741e-09 MirTarget;miRNATAP -0.466264252532839 4.95886616233495e-05 NA NA NA hsa-miR-20a-5p STOM 0.854326758727003 5.04256669663285e-07 -1.17367594082242 4.33645251602994e-16 MirTarget -0.131363211817613 0.00193036612853252 NA NA NA hsa-miR-20a-5p STX1B 0.854326758727003 5.04256669663285e-07 -0.640719876691996 0.00172836284903972 mirMAP -0.256725055224052 8.74254638986174e-06 NA NA NA hsa-miR-192-5p STX3 -0.50188499512787 0.00344713341196035 0.268625915502391 0.0620467313021486 mirMAP -0.211737736672339 1.48582774569338e-07 NA NA NA hsa-miR-27b-3p STX6 -0.823491817819754 9.20935302746823e-14 0.82528361429447 1.08822274383182e-21 miRNATAP -0.160405645302782 3.51623310194333e-05 NA NA NA hsa-miR-192-5p STX7 -0.50188499512787 0.00344713341196035 -0.0311327507585233 0.718803465757857 miRNAWalker2_validate -0.155186048793629 7.95347641737271e-11 NA NA NA hsa-miR-27b-3p STXBP4 -0.823491817819754 9.20935302746823e-14 0.825288412971413 2.03775790430092e-09 mirMAP -0.321635616790522 6.9505961800388e-08 NA NA NA hsa-miR-148a-3p SULF1 -0.748702855596996 3.93313343865641e-07 0.197109789821601 0.550013822507954 miRNATAP -1.08819294190457 4.5465214196856e-27 NA NA NA hsa-miR-27b-3p SULT4A1 -0.823491817819754 9.20935302746823e-14 0.999766279782465 0.0548748431251418 miRNATAP -0.523819206369966 0.01984545649168 NA NA NA hsa-miR-20a-5p SYBU 0.854326758727003 5.04256669663285e-07 -1.03424280598767 8.76454515036323e-06 MirTarget;miRNATAP -0.348242368017228 1.19166978473753e-07 NA NA NA hsa-miR-27b-3p SYDE1 -0.823491817819754 9.20935302746823e-14 -0.0910974798508875 0.557737365754261 miRNATAP -0.168582477232069 0.011669253407176 NA NA NA hsa-miR-148a-3p SYNC -0.748702855596996 3.93313343865641e-07 0.753263996165908 0.0787951206130033 MirTarget -0.607317552921147 1.27523918840447e-05 NA NA NA hsa-miR-20a-5p SYNE1 0.854326758727003 5.04256669663285e-07 -1.52695550653289 5.12596851538943e-24 MirTarget -0.119834307514697 0.00821860657390401 NA NA NA hsa-miR-192-5p SYNGR1 -0.50188499512787 0.00344713341196035 -0.0467874970365392 0.881901328445337 miRNAWalker2_validate -0.468226626727233 1.05709424992985e-07 NA NA NA hsa-miR-20a-5p SYTL4 0.854326758727003 5.04256669663285e-07 -0.551448149757261 0.00433260079085029 mirMAP -0.338761210687631 3.24403485778431e-10 NA NA NA hsa-miR-20a-5p TACC1 0.854326758727003 5.04256669663285e-07 -0.0525566877626078 0.725613334782706 MirTarget -0.276685411340598 2.3182074377097e-11 NA NA NA hsa-miR-148a-3p TAF4B -0.748702855596996 3.93313343865641e-07 -0.601598142975973 0.0171657841614686 MirTarget -0.581392909704103 5.01906359473338e-13 NA NA NA hsa-miR-20a-5p TANC1 0.854326758727003 5.04256669663285e-07 -0.394105811286722 0.0017117377806427 miRNATAP -0.127964743254188 0.000322164186851975 NA NA NA hsa-miR-148a-3p TANC2 -0.748702855596996 3.93313343865641e-07 -0.0777608116505228 0.723192087672004 mirMAP -0.620627143687002 1.35989055902964e-19 NA NA NA hsa-miR-20a-5p TANC2 0.854326758727003 5.04256669663285e-07 -0.0777608116505228 0.723192087672004 mirMAP;miRNATAP -0.201667171708266 0.00113912464289227 NA NA NA hsa-miR-20a-5p TAOK1 0.854326758727003 5.04256669663285e-07 -0.395598965266263 0.0493024563419061 miRNATAP -0.188486126469257 0.000927273169437502 NA NA NA hsa-miR-192-5p TBC1D22B -0.50188499512787 0.00344713341196035 0.743744466929673 5.16477831720913e-15 miRNAWalker2_validate -0.153036094001149 2.38771328736762e-08 NA NA NA hsa-miR-20a-5p TBC1D2B 0.854326758727003 5.04256669663285e-07 -0.400059050118139 0.00112893124682923 mirMAP -0.130138900881065 0.000182172966349087 NA NA NA hsa-miR-20a-5p TBC1D8B 0.854326758727003 5.04256669663285e-07 -0.53149570598194 8.91145403097961e-05 MirTarget -0.195787037864496 3.04952109304305e-07 NA NA NA hsa-miR-20a-5p TBC1D9 0.854326758727003 5.04256669663285e-07 -0.444890138943172 0.00365007351651544 miRNATAP -0.318059650839762 4.92411174285087e-14 NA NA NA hsa-miR-27b-3p TBKBP1 -0.823491817819754 9.20935302746823e-14 0.916427652689533 7.35042591752853e-10 miRNATAP -0.281492405872563 1.47022921301917e-05 NA NA NA hsa-miR-20a-5p TBX3 0.854326758727003 5.04256669663285e-07 -0.441002970053455 0.141364740921892 miRNATAP -0.201549871742771 0.0177860685029896 NA NA NA hsa-miR-20a-5p TCEAL1 0.854326758727003 5.04256669663285e-07 0.223569716788717 0.0751012872781512 miRTarBase -0.13411777219916 0.000150865720190614 NA NA NA hsa-miR-148a-3p TCF4 -0.748702855596996 3.93313343865641e-07 -0.131793886763984 0.355169273660664 MirTarget;miRNATAP -0.199055475462496 1.6155869003118e-05 NA NA NA hsa-miR-20a-5p TCF4 0.854326758727003 5.04256669663285e-07 -0.131793886763984 0.355169273660664 miRNATAP -0.198194274703759 6.70106823990996e-07 NA NA NA hsa-miR-20a-5p TCHH 0.854326758727003 5.04256669663285e-07 -2.31086632807075 2.70172735335336e-20 MirTarget -0.497604794921507 7.86063709665205e-12 NA NA NA hsa-miR-20a-5p TEAD1 0.854326758727003 5.04256669663285e-07 -0.19170590497895 0.104550839525967 mirMAP -0.128813035539309 0.000106602332750709 NA NA NA hsa-miR-20a-5p TET2 0.854326758727003 5.04256669663285e-07 -0.51360079629006 6.77317801124857e-06 miRNATAP -0.123533784404676 0.000141599777866497 NA NA NA hsa-miR-148a-3p TFCP2L1 -0.748702855596996 3.93313343865641e-07 0.0691205247491691 0.814888444830697 mirMAP -0.700020888321756 7.52810321140122e-14 NA NA NA hsa-miR-192-5p TFCP2L1 -0.50188499512787 0.00344713341196035 0.0691205247491691 0.814888444830697 miRNAWalker2_validate -0.433183046361904 1.5634248782453e-07 NA NA NA hsa-miR-148a-3p TFEB -0.748702855596996 3.93313343865641e-07 -0.0772531299287356 0.585189118739078 miRNATAP -0.129311975896433 0.0050431934936616 NA NA NA hsa-miR-20a-5p TFPI2 0.854326758727003 5.04256669663285e-07 -2.98724706930921 5.09535819315938e-23 miRNATAP -0.494670789290977 3.07715671804473e-08 NA NA NA hsa-miR-148a-3p TFRC -0.748702855596996 3.93313343865641e-07 0.937052448042543 3.46645820917872e-11 miRNATAP -0.216653819308525 3.86635919504837e-06 NA NA NA hsa-miR-148a-3p TGFA -0.748702855596996 3.93313343865641e-07 -2.03762583735332 1.70833612877746e-11 miRNATAP -0.794888513212377 5.2082388955199e-16 NA NA NA hsa-miR-148a-3p TGFB2 -0.748702855596996 3.93313343865641e-07 0.529934214584709 0.036730862150581 MirTarget;miRNATAP -0.661431979951743 1.43220896593668e-16 NA NA NA hsa-miR-106b-5p TGFBR2 0.648901865047099 8.24870862047885e-09 -0.522706741081292 3.47206054315007e-05 miRNATAP -0.368277930860382 4.29748674542316e-12 NA NA NA hsa-miR-130b-3p TGFBR2 0.687190305027546 0.000109068658562255 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate;miRNATAP -0.131252693120461 0.000144540113312326 25024357 Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC lung squamous cell cancer hsa-miR-17-5p TGFBR2 0.698861147045461 2.43854106455398e-05 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.203186001893041 2.94531720390227e-08 25011053;27120811 We demonstrate that miR-17 overexpression interferes with the TGFβ-EMT axis and hinders RCC sphere formation; and validated TGFBR2 as a direct and biologically relevant target during this process;MiR-17-5p was found to bind to the 3'UTR of TGFBR2 mRNA and further validation of this specific binding was performed through a reporter assay; An inverse correlation between miR-17-5p and TGFBR2 protein was observed in gastric cancer tissues; Cell studies revealed that miR-17-5p negatively regulated TGFBR2 expression by directly binding to the 3'UTR of TGFBR2 mRNA thereby promoting cell growth and migration; The results of our study suggest a novel regulatory network in gastric cancer mediated by miR-17-5p and TGFBR2 and may indicate that TGFBR2 could serve as a new therapeutic target in gastric cancer ; kidney renal cell cancer;gastric cancer hsa-miR-18a-5p TGFBR2 0.918028187958706 1.90229510425322e-05 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate -0.192780882131928 5.02272007870357e-12 NA NA NA hsa-miR-19a-3p TGFBR2 1.01712596153672 2.57753201450625e-07 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate;miRNATAP -0.149425406079401 1.09582904607366e-06 NA NA NA hsa-miR-19b-3p TGFBR2 0.601279551368824 0.00016685097085251 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate;miRNATAP -0.16137896859351 2.62064707293945e-05 NA NA NA hsa-miR-20a-5p TGFBR2 0.854326758727003 5.04256669663285e-07 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate;miRTarBase;miRNATAP -0.177394018081005 6.48951647363697e-07 NA NA NA hsa-miR-21-5p TGFBR2 1.51084295924322 1.54551622173259e-34 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate;miRTarBase;miRNATAP -0.236840105633096 2.41705180023436e-07 24037531 Androgen receptor and microRNA 21 axis downregulates transforming growth factor beta receptor II TGFBR2 expression in prostate cancer; Our results revealed that miR-21 suppresses TGFBR2 levels by binding to its 3'-UTR and AR signaling further potentiates this effect in both untransformed and transformed human prostate epithelial cells as well as in human prostate cancers; Manipulation of androgen signaling or the expression levels of AR or miR-21 negatively altered TGFBR2 expression in untransformed and transformed human prostate epithelial cells human prostate cancer xenografts and mouse prostate glands; Together these results suggest that the AR and miR-21 axis exerts its oncogenic effects in prostate tumors by downregulating TGFBR2 hence inhibiting the tumor-suppressive activity of TGFβ pathway prostate cancer hsa-miR-301a-3p TGFBR2 0.842910511640361 1.43446467417891e-06 -0.522706741081292 3.47206054315007e-05 miRNATAP -0.183722985598573 1.11942744399345e-07 25551793 MicroRNA 301a promotes migration and invasion by targeting TGFBR2 in human colorectal cancer; TGFBR2 was identified to be the downstream target of miR-301a; Knockdown of TGFBR2 in cells treated by miR-301a inhibitor elevated the previously abrogated migration and invasion; Our data indicated that miR-301a correlated with the metastatic and invasive ability in human colorectal cancers and miR-301a exerted its role as oncogene by targeting TGFBR2 colorectal cancer hsa-miR-454-3p TGFBR2 0.668749059573955 2.42670710515113e-06 -0.522706741081292 3.47206054315007e-05 miRNATAP -0.109462345848673 0.0115970871562665 NA NA NA hsa-miR-501-3p TGFBR2 0.999540908940094 2.77358485581974e-11 -0.522706741081292 3.47206054315007e-05 TargetScan -0.116887889145825 0.0037841236086272 NA NA NA hsa-miR-590-5p TGFBR2 -0.103355559980404 0.310027295317092 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate;miRTarBase;PITA;miRanda;miRNATAP -0.253149374960949 3.5308611333711e-05 NA NA NA hsa-miR-92a-3p TGFBR2 0.212391012518195 0.134292268089997 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate -0.17351362748106 7.02401539230513e-05 NA NA NA hsa-miR-93-5p TGFBR2 1.39518349670953 2.84167728726712e-25 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate;miRNATAP -0.263677361634044 7.09611188180981e-10 NA NA NA hsa-miR-20a-5p TGFBRAP1 0.854326758727003 5.04256669663285e-07 -0.505136451922138 0.0449301720842251 MirTarget -0.168465523858867 0.0184818927101042 NA NA NA hsa-miR-148a-3p TGIF2 -0.748702855596996 3.93313343865641e-07 0.183370689181392 0.147188585278003 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.247629083555228 9.91349025355731e-10 26638007 Down Regulation of miR 148a Promotes Metastasis by DNA Methylation and is Associated with Prognosis of Skin Cancer by Targeting TGIF2; The purpose of this study was to investigate the methylation status of miR-148a and its effects on the metastasis and prognosis of skin cancer as well as the interaction with TGIF2 gene; Luciferase reporter assay found that TGIF2 gene was a target gene and its expression was suppressed by miR-148a in skin cancer; CONCLUSIONS Taken together the expression of miR-148a was regulated by DNA methylation and targeted by TGIF2 metastasis;worse prognosis sarcoma hsa-miR-20a-5p TGM2 0.854326758727003 5.04256669663285e-07 -0.875329681872056 2.87786913171852e-06 MirTarget -0.235089408184339 9.91861947467251e-06 NA NA NA hsa-miR-20a-5p TGOLN2 0.854326758727003 5.04256669663285e-07 -0.429830131076565 1.22459702243077e-05 miRNATAP -0.117054523545595 2.65375505523254e-05 NA NA NA hsa-miR-192-5p THBD -0.50188499512787 0.00344713341196035 -1.54895902663437 4.76827970625926e-16 miRNAWalker2_validate -0.239998091360237 1.67811812932913e-05 NA NA NA hsa-miR-20a-5p THBS1 0.854326758727003 5.04256669663285e-07 -2.1667874641621 3.47909831637717e-17 miRNAWalker2_validate -0.298190202548282 7.75927048516442e-05 NA NA NA hsa-miR-20a-5p THBS2 0.854326758727003 5.04256669663285e-07 -0.502816786435579 0.158172197533798 MirTarget -0.441793484244088 1.04186713814831e-05 NA NA NA hsa-miR-27b-3p THOC3 -0.823491817819754 9.20935302746823e-14 0.399276721087312 1.25813661136998e-05 miRNAWalker2_validate -0.100230624594301 0.0114805247490654 NA NA NA hsa-miR-20a-5p THSD4 0.854326758727003 5.04256669663285e-07 -1.03249520260707 2.68769926118397e-05 mirMAP -0.388484475320056 2.07528237316178e-08 NA NA NA hsa-miR-92a-1-5p THSD4 0.389443191151075 0.0644925359204601 -1.03249520260707 2.68769926118397e-05 mirMAP -0.312612393100384 3.64814950159717e-08 NA NA NA hsa-miR-20a-5p TIAM1 0.854326758727003 5.04256669663285e-07 -1.56411477781397 6.02866811798354e-13 MirTarget;miRNATAP -0.146807750673643 0.0206517910606264 NA NA NA hsa-miR-20a-5p TIMP2 0.854326758727003 5.04256669663285e-07 -0.599071024246221 0.00246039513439785 miRNATAP -0.205613097275286 0.00024396525545413 25803820 TIMP2 and ATG7 were proved to be direct targets of miR-20a using luciferase assay and western blot; These results indicate that miR-20a suppresses the proliferation migration and invasion of cervical cancer cell through targeting ATG7 and TIMP2 cervical and endocervical cancer hsa-miR-20a-5p TIMP3 0.854326758727003 5.04256669663285e-07 -0.479569227754572 0.00042274706056242 miRNATAP -0.209156104661086 4.35176096892657e-08 NA NA NA hsa-miR-20a-5p TM2D2 0.854326758727003 5.04256669663285e-07 -0.658110740005188 1.44619249421993e-09 MirTarget -0.139506870224655 7.42705790412749e-06 NA NA NA hsa-miR-20a-5p TMBIM6 0.854326758727003 5.04256669663285e-07 -0.8739716428039 2.36157745837239e-20 MirTarget -0.158620763573786 9.13566133953307e-09 NA NA NA hsa-miR-20a-5p TMCC1 0.854326758727003 5.04256669663285e-07 -0.104762238614036 0.46647436251659 miRNATAP -0.174456732740266 1.56291955192924e-05 NA NA NA hsa-miR-148a-3p TMCC3 -0.748702855596996 3.93313343865641e-07 0.117668394353186 0.425707008413695 MirTarget -0.155039139325215 0.00125905353152064 NA NA NA hsa-miR-192-5p TMED8 -0.50188499512787 0.00344713341196035 -0.0859822378570407 0.256018887842563 mirMAP -0.167396847114565 4.28061364398208e-16 NA NA NA hsa-miR-192-5p TMEFF1 -0.50188499512787 0.00344713341196035 1.22531596486822 7.35301173500991e-15 miRNAWalker2_validate -0.322987843255821 6.94230029538015e-13 NA NA NA hsa-miR-192-5p TMEM106A -0.50188499512787 0.00344713341196035 -0.835180568547328 2.66119460421375e-05 miRNAWalker2_validate -0.138386763607983 0.0150211919278464 NA NA NA hsa-miR-148a-3p TMEM120B -0.748702855596996 3.93313343865641e-07 1.34193310296135 3.11902100235044e-43 mirMAP -0.172599931857059 8.02056011224422e-07 NA NA NA hsa-miR-20a-5p TMEM127 0.854326758727003 5.04256669663285e-07 -0.0573335513156676 0.30489427729561 MirTarget -0.113349061962351 8.70324120705327e-14 NA NA NA hsa-miR-192-5p TMEM136 -0.50188499512787 0.00344713341196035 1.15723298299266 1.09507071750269e-09 miRNAWalker2_validate -0.397818589478256 9.10564201932977e-14 NA NA NA hsa-miR-192-5p TMEM164 -0.50188499512787 0.00344713341196035 1.2706908651988 7.63591092247221e-16 miRNAWalker2_validate -0.21707054410531 2.27782314707691e-06 NA NA NA hsa-miR-27b-3p TMEM167A -0.823491817819754 9.20935302746823e-14 0.212640777093779 0.00146514175351927 MirTarget -0.146823135397722 2.28365971146748e-07 NA NA NA hsa-miR-192-5p TMEM200A -0.50188499512787 0.00344713341196035 0.396404896579977 0.139145977799248 miRNAWalker2_validate -0.629992694002355 6.30227581488032e-18 NA NA NA hsa-miR-148a-3p TMEM54 -0.748702855596996 3.93313343865641e-07 0.339956153918932 0.165699757140974 MirTarget -0.55222112886462 1.54566938175757e-12 NA NA NA hsa-miR-20a-5p TMEM56 0.854326758727003 5.04256669663285e-07 -1.75634225549522 4.44536598470124e-19 MirTarget -0.155425344672029 0.00770747316438073 NA NA NA hsa-miR-92a-1-5p TMEM56 0.389443191151075 0.0644925359204601 -1.75634225549522 4.44536598470124e-19 MirTarget -0.114124964108048 0.0169286732223112 NA NA NA hsa-miR-20a-5p TMEM64 0.854326758727003 5.04256669663285e-07 -0.00136604960589803 0.993609309009731 MirTarget;miRNATAP -0.171418847947302 0.000361432121905777 NA NA NA hsa-miR-92a-1-5p TMEM64 0.389443191151075 0.0644925359204601 -0.00136604960589803 0.993609309009731 MirTarget -0.222473817213409 1.04711875356661e-08 NA NA NA hsa-miR-148a-3p TMEM9B -0.748702855596996 3.93313343865641e-07 0.0287463993115633 0.684276222499031 miRNAWalker2_validate;miRNATAP -0.115744129064157 3.2275770465905e-07 NA NA NA hsa-miR-20a-5p TMOD2 0.854326758727003 5.04256669663285e-07 0.273439557141349 0.0664976053061536 mirMAP -0.162530598469261 0.000108983811206762 NA NA NA hsa-miR-148a-3p TMSB10 -0.748702855596996 3.93313343865641e-07 0.855988582085651 2.64785852790295e-05 miRNATAP -0.801496222431267 2.12040705537655e-39 NA NA NA hsa-miR-27b-3p TMSB10 -0.823491817819754 9.20935302746823e-14 0.855988582085651 2.64785852790295e-05 miRNATAP -0.315676324207405 0.000347704005746108 NA NA NA hsa-miR-192-5p TMTC2 -0.50188499512787 0.00344713341196035 -0.146251758768581 0.50856985156897 miRNAWalker2_validate -0.417459076838182 8.968195445829e-12 NA NA NA hsa-miR-27b-3p TMTC2 -0.823491817819754 9.20935302746823e-14 -0.146251758768581 0.50856985156897 MirTarget;miRNATAP -0.293952020200257 0.00198649367928741 NA NA NA hsa-miR-20a-5p TNFAIP1 0.854326758727003 5.04256669663285e-07 -0.25456481631844 0.00166535803744622 MirTarget -0.104426959927961 4.36585638472708e-06 NA NA NA hsa-miR-192-5p TNFRSF11A -0.50188499512787 0.00344713341196035 0.244304748708084 0.307235137168618 mirMAP -0.27584547000856 4.25380209512195e-05 NA NA NA hsa-miR-20a-5p TNFRSF1B 0.854326758727003 5.04256669663285e-07 -0.842653559102565 4.93648097238325e-09 mirMAP -0.158235148112825 0.00013043223392706 NA NA NA hsa-miR-192-5p TNFSF13 -0.50188499512787 0.00344713341196035 -1.05870744956172 9.5489039983648e-11 miRNAWalker2_validate -0.230987916512773 8.64350878472076e-07 NA NA NA hsa-miR-192-5p TNFSF13B -0.50188499512787 0.00344713341196035 -0.866597065976523 0.000286882542745221 miRNAWalker2_validate -0.342820394368764 3.67666104026941e-07 NA NA NA hsa-miR-148a-3p TNIP2 -0.748702855596996 3.93313343865641e-07 0.335021770072243 5.14349905101051e-05 MirTarget -0.153853270059096 8.46593726591456e-09 NA NA NA hsa-miR-20a-5p TNKS1BP1 0.854326758727003 5.04256669663285e-07 -0.420431716205674 1.90084489041169e-07 MirTarget;miRNATAP -0.16886938577336 5.04077278422703e-14 NA NA NA hsa-miR-27b-3p TOX -0.823491817819754 9.20935302746823e-14 -0.725976975588079 0.0301887887319555 miRNATAP -0.5483365925563 0.000138835469870354 NA NA NA hsa-miR-148a-3p TPCN1 -0.748702855596996 3.93313343865641e-07 0.601482422409012 3.05338746481423e-08 mirMAP -0.175550226951548 8.36740565092831e-07 NA NA NA hsa-miR-192-5p TPCN1 -0.50188499512787 0.00344713341196035 0.601482422409012 3.05338746481423e-08 mirMAP -0.117465561992072 0.000158835259431966 NA NA NA hsa-miR-192-5p TPM4 -0.50188499512787 0.00344713341196035 0.3605306383464 0.00979481452100365 miRNAWalker2_validate -0.441147882156579 1.54587215893729e-33 NA NA NA hsa-miR-92a-1-5p TPPP 0.389443191151075 0.0644925359204601 -0.469611426280087 0.0675897589786415 mirMAP -0.226642735707155 0.000134546631942986 NA NA NA hsa-miR-26b-5p TRAF1 -1.10804856399744 4.14176110314282e-22 0.712897834079886 6.33601713412082e-09 miRNAWalker2_validate -0.146366230286123 0.00384999561270946 NA NA NA hsa-miR-30e-3p TRAF1 -1.20845647373031 3.10263633528203e-25 0.712897834079886 6.33601713412082e-09 mirMAP -0.220388103763073 7.10147510001104e-06 NA NA NA hsa-miR-378a-3p TRAF1 -1.1920055906972 3.23538871733634e-10 0.712897834079886 6.33601713412082e-09 miRNAWalker2_validate -0.124374707900819 6.92942238884749e-05 NA NA NA hsa-miR-20a-5p TRAF3IP2 0.854326758727003 5.04256669663285e-07 -0.495501255758086 0.000506806108002448 mirMAP -0.216942503737222 5.96011703902813e-08 NA NA NA hsa-miR-192-5p TRAF3IP3 -0.50188499512787 0.00344713341196035 -0.165007606635018 0.391852764417264 miRNAWalker2_validate -0.221747549532359 4.35746573073182e-05 NA NA NA hsa-miR-148a-3p TRAK1 -0.748702855596996 3.93313343865641e-07 0.112414901890156 0.161096546776779 miRNATAP -0.138439950489541 7.44379860540538e-08 NA NA NA hsa-miR-148a-3p TRAK2 -0.748702855596996 3.93313343865641e-07 -0.134753128051574 0.118953684351514 MirTarget;miRNATAP -0.138259168259446 6.72843502340937e-07 NA NA NA hsa-miR-192-5p TRERF1 -0.50188499512787 0.00344713341196035 -0.366863939887298 0.0331874158506003 miRNATAP -0.372471969641296 3.43892887381849e-15 NA NA NA hsa-miR-27b-3p TRERF1 -0.823491817819754 9.20935302746823e-14 -0.366863939887298 0.0331874158506003 miRNATAP -0.173842664639369 0.019362567526454 NA NA NA hsa-miR-27b-3p TRIL -0.823491817819754 9.20935302746823e-14 0.68492919428511 1.15435507123196e-06 MirTarget -0.153304836819414 0.0125478351411271 NA NA NA hsa-miR-27b-3p TRIM21 -0.823491817819754 9.20935302746823e-14 -0.16414063988104 0.114603639312823 MirTarget -0.11971312668288 0.00739964740946908 NA NA NA hsa-miR-20a-5p TRIM36 0.854326758727003 5.04256669663285e-07 0.114048335730387 0.617831221674831 MirTarget;miRNATAP -0.266178362356448 3.47005917848808e-05 NA NA NA hsa-miR-148a-3p TRIM59 -0.748702855596996 3.93313343865641e-07 1.7356935499647 4.96522875209022e-19 miRNAWalker2_validate;MirTarget -0.530631145085023 1.38548428892168e-16 NA NA NA hsa-miR-192-5p TRIM59 -0.50188499512787 0.00344713341196035 1.7356935499647 4.96522875209022e-19 miRNAWalker2_validate -0.243147327759177 2.25863404843399e-05 NA NA NA hsa-miR-192-5p TRIM67 -0.50188499512787 0.00344713341196035 0.526474972444801 0.0261906603203476 mirMAP -0.293477263472278 1.09731353779698e-05 NA NA NA hsa-miR-27b-3p TRIM67 -0.823491817819754 9.20935302746823e-14 0.526474972444801 0.0261906603203476 mirMAP -0.232021312153903 0.0233250108376052 NA NA NA hsa-miR-20a-5p TRIP11 0.854326758727003 5.04256669663285e-07 -0.200994211822031 0.0443801393217673 miRNATAP -0.124161375309083 9.61909880244207e-06 NA NA NA hsa-miR-192-5p TRIP13 -0.50188499512787 0.00344713341196035 3.40696055788158 8.8617706442272e-44 miRNAWalker2_validate -0.323478417816599 2.76454108833635e-05 NA NA NA hsa-miR-192-5p TRPC1 -0.50188499512787 0.00344713341196035 0.308490971924318 0.14555420535354 miRNAWalker2_validate -0.348058000322841 3.86230960675937e-09 NA NA NA hsa-miR-148a-3p TRPS1 -0.748702855596996 3.93313343865641e-07 0.234327311753334 0.28887714546093 miRNATAP -0.232765974533109 0.00122300098269749 NA NA NA hsa-miR-20a-5p TRPV6 0.854326758727003 5.04256669663285e-07 -4.08292783556857 1.32667949131395e-19 miRNATAP -0.60668935528315 4.90662685916048e-06 NA NA NA hsa-miR-20a-5p TSHZ3 0.854326758727003 5.04256669663285e-07 -0.769757153572753 6.19298715512245e-06 MirTarget;miRNATAP -0.292148188322042 1.04807086484758e-09 NA NA NA hsa-miR-192-5p TSPAN3 -0.50188499512787 0.00344713341196035 0.0573084342867682 0.616032989656141 mirMAP -0.194699849091232 8.17946134781559e-10 NA NA NA hsa-miR-20a-5p TSPAN5 0.854326758727003 5.04256669663285e-07 0.521509853347309 0.137106034516152 mirMAP -0.360911157856223 0.000268598415972188 NA NA NA hsa-miR-20a-5p TSPYL5 0.854326758727003 5.04256669663285e-07 -1.77057901747748 4.6912848761307e-17 mirMAP -0.335016051284729 4.76732203816453e-08 NA NA NA hsa-miR-92a-1-5p TTBK1 0.389443191151075 0.0644925359204601 -0.828139372024007 0.00392617205238364 mirMAP -0.159694424419265 0.0169841837684302 NA NA NA hsa-miR-27b-3p TTC39A -0.823491817819754 9.20935302746823e-14 2.64467452765163 1.3333642353103e-14 mirMAP -0.650911024455246 1.85447564392055e-05 NA NA NA hsa-miR-20a-5p TTC9 0.854326758727003 5.04256669663285e-07 1.33647962627701 1.22234162293908e-06 miRNATAP -0.584639517192676 2.46906403320725e-14 NA NA NA hsa-miR-192-5p TTF2 -0.50188499512787 0.00344713341196035 1.03578447746635 1.88065403311168e-12 miRNAWalker2_validate -0.208281845740539 8.99265624074137e-07 NA NA NA hsa-miR-139-5p TTK -2.11299531796557 8.16407076415038e-28 4.46695225538541 3.90954998066403e-48 miRanda -1.02753150497536 5.11914670343957e-45 NA NA NA hsa-miR-215-5p TTK -0.981544773246509 3.14452272477156e-05 4.46695225538541 3.90954998066403e-48 miRNAWalker2_validate -0.154558614985227 0.0292381161076613 NA NA NA hsa-miR-455-3p TTK -1.3998033821095 5.72010709806871e-17 4.46695225538541 3.90954998066403e-48 miRNATAP -0.457661482122706 1.91508543926432e-06 NA NA NA hsa-miR-20a-5p TTLL7 0.854326758727003 5.04256669663285e-07 -0.174209860799301 0.581064288483948 mirMAP -0.3261995488826 0.00024800581064627 NA NA NA hsa-miR-148a-3p TTYH3 -0.748702855596996 3.93313343865641e-07 0.770555614902691 1.06180020960171e-06 mirMAP -0.336909304109069 4.30253872401559e-11 NA NA NA hsa-miR-192-5p TTYH3 -0.50188499512787 0.00344713341196035 0.770555614902691 1.06180020960171e-06 mirMAP -0.229547107590934 2.97485668658504e-07 NA NA NA hsa-miR-27b-3p TTYH3 -0.823491817819754 9.20935302746823e-14 0.770555614902691 1.06180020960171e-06 miRNATAP -0.302565000871573 9.53937852045108e-06 NA NA NA hsa-miR-20a-5p TXNIP 0.854326758727003 5.04256669663285e-07 -1.09755600933445 1.08530493651829e-08 MirTarget -0.149396599341359 0.00695907025602225 NA NA NA hsa-miR-148a-3p UBASH3B -0.748702855596996 3.93313343865641e-07 -0.366176880641331 0.0811617780784009 MirTarget -0.844727394486042 1.96609914042261e-42 NA NA NA hsa-miR-192-5p UBASH3B -0.50188499512787 0.00344713341196035 -0.366176880641331 0.0811617780784009 miRNAWalker2_validate -0.600320995326487 6.37528716374657e-27 NA NA NA hsa-miR-27b-3p UBASH3B -0.823491817819754 9.20935302746823e-14 -0.366176880641331 0.0811617780784009 miRNATAP -0.253140145985266 0.00512869243775859 NA NA NA hsa-miR-20a-5p UBC 0.854326758727003 5.04256669663285e-07 -0.0906814920157917 0.264389268870947 miRNATAP -0.123562766810762 4.44028845336169e-08 NA NA NA hsa-miR-148a-3p UBE2D1 -0.748702855596996 3.93313343865641e-07 0.0779402641757883 0.369347660871645 MirTarget;miRNATAP -0.171046474154817 6.65939304887809e-10 NA NA NA hsa-miR-192-5p UBE2D1 -0.50188499512787 0.00344713341196035 0.0779402641757883 0.369347660871645 miRNAWalker2_validate -0.106222155367363 1.24584492034061e-05 NA NA NA hsa-miR-27b-3p UBE2Q1 -0.823491817819754 9.20935302746823e-14 0.732919157465649 1.09455000536515e-20 miRNATAP -0.159343362586928 5.72262827193909e-06 NA NA NA hsa-miR-20a-5p UBE2W 0.854326758727003 5.04256669663285e-07 -0.253775104248129 0.00271466702277899 miRNATAP -0.14523471171116 6.7036980285473e-10 NA NA NA hsa-miR-20a-5p UBE3C 0.854326758727003 5.04256669663285e-07 0.0110137435810636 0.905807612215828 MirTarget;miRNATAP -0.131292933667327 4.20100986749961e-07 NA NA NA hsa-miR-20a-5p UBR1 0.854326758727003 5.04256669663285e-07 -0.388222830350535 1.99950729008068e-05 miRNATAP -0.16222861718641 1.75388077295459e-10 NA NA NA hsa-miR-27b-3p UBR5 -0.823491817819754 9.20935302746823e-14 0.630017235825055 3.7913049521189e-11 MirTarget;miRNATAP -0.140975760866304 0.000750274945723454 NA NA NA hsa-miR-148a-3p UCP3 -0.748702855596996 3.93313343865641e-07 0.738404617511284 2.64780777542046e-07 MirTarget;miRNATAP -0.159569280850398 0.000757623579332943 NA NA NA hsa-miR-20a-5p UEVLD 0.854326758727003 5.04256669663285e-07 0.0899769025084192 0.456741370818853 miRNAWalker2_validate;MirTarget -0.133989226000398 8.03819083058733e-05 NA NA NA hsa-miR-192-5p UGT8 -0.50188499512787 0.00344713341196035 0.668138341470101 0.0469987718329836 miRNAWalker2_validate -0.292812729409313 0.00213398234566189 NA NA NA hsa-miR-20a-5p UHMK1 0.854326758727003 5.04256669663285e-07 -0.803204254827771 0.00347508080027661 mirMAP -0.329720592307185 2.18163348512908e-05 NA NA NA hsa-miR-27b-3p UHRF1BP1 -0.823491817819754 9.20935302746823e-14 0.5401627924825 2.70756975187287e-07 miRNATAP -0.108348341530582 0.018063405662785 NA NA NA hsa-miR-192-5p UNC119B -0.50188499512787 0.00344713341196035 1.21392832041535 7.88210718787103e-18 mirMAP -0.156987527395048 0.000155556485932823 NA NA NA hsa-miR-27b-3p UNC119B -0.823491817819754 9.20935302746823e-14 1.21392832041535 7.88210718787103e-18 mirMAP -0.146934003101591 0.0205159803633217 NA NA NA hsa-miR-148a-3p UNC13A -0.748702855596996 3.93313343865641e-07 1.88006027872507 4.70766140336401e-08 mirMAP -0.737009176311451 4.54389881051152e-11 NA NA NA hsa-miR-27b-3p UNKL -0.823491817819754 9.20935302746823e-14 1.03406637414326 3.3981116867897e-18 miRNATAP -0.192465763822915 0.000296826295135369 NA NA NA hsa-miR-192-5p UPP1 -0.50188499512787 0.00344713341196035 -0.042917024406242 0.760665276477023 miRNAWalker2_validate -0.188379087453598 1.81656919109085e-06 NA NA NA hsa-miR-27b-3p USP46 -0.823491817819754 9.20935302746823e-14 0.37866037663651 5.0736070332912e-05 MirTarget;miRNATAP -0.127230167124479 0.00163105940505326 NA NA NA hsa-miR-20a-5p USP53 0.854326758727003 5.04256669663285e-07 -0.885109860248228 1.92362967555312e-09 miRNATAP -0.308556869030845 8.6106929234526e-14 NA NA NA hsa-miR-192-5p USP54 -0.50188499512787 0.00344713341196035 0.621564566787767 0.00139361741036206 miRNAWalker2_validate -0.135230658318964 0.014674125054071 NA NA NA hsa-miR-27b-3p UTP14A -0.823491817819754 9.20935302746823e-14 0.666909942791138 4.39528354807288e-15 miRNAWalker2_validate -0.164568511837303 1.1443127408687e-05 NA NA NA hsa-miR-148a-3p VANGL1 -0.748702855596996 3.93313343865641e-07 0.205997711038247 0.0305684838094997 mirMAP -0.147424701729889 1.65338009649548e-06 NA NA NA hsa-miR-192-5p VANGL1 -0.50188499512787 0.00344713341196035 0.205997711038247 0.0305684838094997 miRNAWalker2_validate -0.228603360029257 8.99222292327043e-19 NA NA NA hsa-miR-148a-3p VASH1 -0.748702855596996 3.93313343865641e-07 0.376667961316505 0.00837588570446168 mirMAP -0.483186841432644 2.09378989906879e-28 NA NA NA hsa-miR-192-5p VASH1 -0.50188499512787 0.00344713341196035 0.376667961316505 0.00837588570446168 mirMAP -0.342610515460023 1.31882880179242e-18 NA NA NA hsa-miR-192-5p VASH2 -0.50188499512787 0.00344713341196035 1.99409120294188 1.83824386478745e-12 miRNAWalker2_validate -0.167197626011626 0.0431316269095107 NA NA NA hsa-miR-27b-3p VDR -0.823491817819754 9.20935302746823e-14 0.285990861463055 0.253050689197296 miRNAWalker2_validate;miRTarBase -0.228388027467094 0.0343140214017218 22213330 The expression of VDR mRNA protein and two candidates of VDR microRNAs miR-125b miR-27b were compared in 125OH2D3-responsive MeWo SK-Mel28 and -resistant SK-Mel5 IGR melanoma cell lines and in normal human melanocytes NHM using real time PCR and western blot analysis melanoma hsa-miR-27b-3p VGF -0.823491817819754 9.20935302746823e-14 1.16356565087002 0.000378418082123557 miRNATAP -0.667992401178543 2.03727683507418e-06 NA NA NA hsa-miR-192-5p VGLL3 -0.50188499512787 0.00344713341196035 -0.294230399406651 0.235396784808845 miRNAWalker2_validate -0.41378530704369 2.08640774662643e-09 NA NA NA hsa-miR-20a-5p VGLL3 0.854326758727003 5.04256669663285e-07 -0.294230399406651 0.235396784808845 mirMAP -0.392910736979021 1.34602750647278e-08 NA NA NA hsa-miR-20a-5p VLDLR 0.854326758727003 5.04256669663285e-07 -0.0354447533347528 0.927085642100091 MirTarget;miRNATAP -0.583432446282251 6.96273143743137e-08 NA NA NA hsa-miR-20a-5p VPS13C 0.854326758727003 5.04256669663285e-07 -0.351124153310034 0.00206558617446539 MirTarget -0.188265323528369 3.30757552196579e-09 NA NA NA hsa-miR-148a-3p VSIG1 -0.748702855596996 3.93313343865641e-07 1.90287436342957 8.4567956200768e-06 MirTarget -1.08529741673112 1.88037146106369e-15 NA NA NA hsa-miR-148a-3p VSIG10 -0.748702855596996 3.93313343865641e-07 0.873850880690775 6.42061314499011e-13 MirTarget -0.233949805248073 5.70720661265099e-09 NA NA NA hsa-miR-20a-5p WDFY3 0.854326758727003 5.04256669663285e-07 -0.56665445395217 1.30950023006267e-05 MirTarget;miRNATAP -0.233851435646906 1.3191917612642e-10 NA NA NA hsa-miR-27b-3p WDR37 -0.823491817819754 9.20935302746823e-14 0.118154887215613 0.147861987325504 miRNATAP -0.104092327240391 0.00290740843368926 NA NA NA hsa-miR-192-5p WDR47 -0.50188499512787 0.00344713341196035 -0.0410364454978813 0.699801723145165 miRNAWalker2_validate -0.133275888079536 7.85584446595926e-06 NA NA NA hsa-miR-148a-3p WNK2 -0.748702855596996 3.93313343865641e-07 -1.89518323977929 0.000316140316980393 mirMAP -1.46012560842666 1.47894869196561e-18 NA NA NA hsa-miR-27b-3p WNT3A -0.823491817819754 9.20935302746823e-14 1.98708616870099 1.63071643507271e-06 miRNATAP -0.548421477531898 0.00239496180403094 NA NA NA hsa-miR-10b-5p WNT7B 2.86931593037303 6.97409423207806e-23 -2.49986156980565 3.55477150766295e-09 mirMAP -0.274981207829556 5.13137898629338e-05 NA NA NA hsa-miR-34a-5p WNT7B 1.03694231790865 5.74864019540594e-14 -2.49986156980565 3.55477150766295e-09 mirMAP -0.871435014929295 2.29802092991709e-09 NA NA NA hsa-miR-505-3p WNT7B -1.20027021591555 1.27927500175937e-13 -2.49986156980565 3.55477150766295e-09 miRNATAP -0.343304152336908 0.00653008300029439 NA NA NA hsa-miR-664a-5p WNT7B -0.0738022124558593 0.597681758599428 -2.49986156980565 3.55477150766295e-09 MirTarget -0.350084715832488 0.0208450119464205 NA NA NA hsa-miR-27b-3p WSB1 -0.823491817819754 9.20935302746823e-14 0.0151743647458531 0.894086000237508 MirTarget -0.121375020342005 0.0131677403362887 NA NA NA hsa-miR-20a-5p WWC1 0.854326758727003 5.04256669663285e-07 -0.0161026660407861 0.921171669363241 mirMAP -0.128497978139045 0.00519897748400934 NA NA NA hsa-miR-192-5p WWC3 -0.50188499512787 0.00344713341196035 0.418904533622248 0.000277343107042062 miRNAWalker2_validate -0.253775313448794 1.24286775769514e-15 NA NA NA hsa-miR-20a-5p XIAP 0.854326758727003 5.04256669663285e-07 -0.15308594423064 0.0753030128680062 miRNATAP -0.159439128688726 1.8964942127771e-11 NA NA NA hsa-miR-27b-3p XPO1 -0.823491817819754 9.20935302746823e-14 0.457663973329897 3.78607050139453e-13 miRNATAP -0.105363493354515 0.000135972684704308 NA NA NA hsa-miR-20a-5p XRN1 0.854326758727003 5.04256669663285e-07 -0.583371990207323 2.03152104936498e-09 MirTarget;miRNATAP -0.103377808005773 0.000213791480229131 NA NA NA hsa-miR-148a-3p XYLT1 -0.748702855596996 3.93313343865641e-07 -0.33071246838403 0.0992663538586554 mirMAP -0.574785330152198 4.45980178241601e-20 NA NA NA hsa-miR-20a-5p XYLT1 0.854326758727003 5.04256669663285e-07 -0.33071246838403 0.0992663538586554 mirMAP -0.267618441834841 2.01222160008557e-06 NA NA NA hsa-miR-192-5p YKT6 -0.50188499512787 0.00344713341196035 0.744521665004512 6.43148276458938e-19 mirMAP -0.184317352823526 1.58004815463837e-14 NA NA NA hsa-miR-20a-5p YPEL1 0.854326758727003 5.04256669663285e-07 -0.0280512828396375 0.84677585658497 MirTarget -0.118192189384931 0.0039389305228129 NA NA NA hsa-miR-148a-3p YWHAB -0.748702855596996 3.93313343865641e-07 0.173432047741129 0.000884243127746855 MirTarget;miRNATAP -0.132820922282045 4.13292521804208e-16 NA NA NA hsa-miR-20a-5p ZADH2 0.854326758727003 5.04256669663285e-07 -1.17032856012737 5.54900778507354e-29 MirTarget -0.124416330397247 8.4080772800613e-05 NA NA NA hsa-miR-148a-3p ZBED4 -0.748702855596996 3.93313343865641e-07 0.53235542847144 2.61984249684361e-08 miRNATAP -0.143825624792037 4.72475716954346e-06 NA NA NA hsa-miR-192-5p ZBTB4 -0.50188499512787 0.00344713341196035 -0.124027749172316 0.179982248480507 miRNATAP -0.272262427336687 5.98537345709053e-29 NA NA NA hsa-miR-20a-5p ZBTB4 0.854326758727003 5.04256669663285e-07 -0.124027749172316 0.179982248480507 MirTarget;miRNATAP -0.188729695695599 1.00298776596306e-13 NA NA NA hsa-miR-27b-3p ZBTB41 -0.823491817819754 9.20935302746823e-14 0.681392504641194 1.18278307943778e-07 MirTarget -0.173093239984597 0.00203901987506602 NA NA NA hsa-miR-148a-3p ZBTB46 -0.748702855596996 3.93313343865641e-07 0.368572640104064 0.00472649256163026 mirMAP -0.261027892187004 4.71083373690452e-10 NA NA NA hsa-miR-192-5p ZBTB46 -0.50188499512787 0.00344713341196035 0.368572640104064 0.00472649256163026 mirMAP -0.153748296687761 2.97987507117192e-05 NA NA NA hsa-miR-20a-5p ZBTB7A 0.854326758727003 5.04256669663285e-07 -0.16342620037259 0.0332447232508199 MirTarget;miRNATAP -0.158307583516785 5.0814483994578e-14 NA NA NA hsa-miR-92a-1-5p ZBTB7A 0.389443191151075 0.0644925359204601 -0.16342620037259 0.0332447232508199 MirTarget -0.121375346257418 2.18308913687238e-12 NA NA NA hsa-miR-20a-5p ZC3H12C 0.854326758727003 5.04256669663285e-07 -0.901395268828268 9.92571024572182e-11 MirTarget;miRNATAP -0.237873217891635 2.04220503571936e-09 NA NA NA hsa-miR-20a-5p ZDHHC1 0.854326758727003 5.04256669663285e-07 -0.618301483420499 0.0045534659253571 MirTarget;miRNATAP -0.368953726193122 1.34601303638492e-09 NA NA NA hsa-miR-192-5p ZDHHC2 -0.50188499512787 0.00344713341196035 -1.00761289977392 6.32790244881183e-07 miRNAWalker2_validate;MirTarget -0.194580660815328 0.000787838638573794 NA NA NA hsa-miR-148a-3p ZDHHC23 -0.748702855596996 3.93313343865641e-07 0.31113543845786 0.027353194603354 MirTarget -0.193066199183344 2.48865332154847e-05 NA NA NA hsa-miR-148a-3p ZDHHC7 -0.748702855596996 3.93313343865641e-07 0.0927070329222683 0.321096181728645 MirTarget;miRNATAP -0.348656796446493 6.48216350335255e-36 NA NA NA hsa-miR-192-5p ZEB2 -0.50188499512787 0.00344713341196035 -1.50896689448163 2.21480558222559e-19 MirTarget;miRNATAP -0.325488676967802 2.20421079157058e-11 NA NA NA hsa-miR-20a-5p ZFAND5 0.854326758727003 5.04256669663285e-07 -0.89687020061194 5.59442964172277e-08 mirMAP -0.182867722857365 0.000110197600724576 NA NA NA hsa-miR-20a-5p ZFP91 0.854326758727003 5.04256669663285e-07 -0.225485146491446 0.00482633262124725 MirTarget;miRNATAP -0.11317908809573 4.2408914804633e-07 NA NA NA hsa-miR-148a-3p ZFPM2 -0.748702855596996 3.93313343865641e-07 -2.22408950189141 1.94401967403455e-22 miRNATAP -0.168857556123059 0.0322360782737704 NA NA NA hsa-miR-20a-5p ZFPM2 0.854326758727003 5.04256669663285e-07 -2.22408950189141 1.94401967403455e-22 miRNATAP -0.440517313452057 4.28744144255194e-11 NA NA NA hsa-miR-20a-5p ZFYVE21 0.854326758727003 5.04256669663285e-07 -0.507343806467437 4.4231530346861e-09 miRNATAP -0.174498640052848 5.70124909699998e-13 NA NA NA hsa-miR-20a-5p ZFYVE9 0.854326758727003 5.04256669663285e-07 -0.342162134568488 0.000131097224279702 MirTarget;miRNATAP -0.14106974348761 1.81731985175181e-08 NA NA NA hsa-miR-20a-5p ZHX3 0.854326758727003 5.04256669663285e-07 -0.0728476988937654 0.495793402490393 mirMAP -0.124549602671161 3.3127133818874e-05 NA NA NA hsa-miR-20a-5p ZMAT3 0.854326758727003 5.04256669663285e-07 -0.69014006285696 7.01619041120993e-05 mirMAP -0.279960410353906 9.5889879711568e-09 NA NA NA hsa-miR-27b-3p ZNF207 -0.823491817819754 9.20935302746823e-14 0.476017454845254 1.69423309001909e-17 mirMAP -0.106393017895663 1.61926010616278e-05 NA NA NA hsa-miR-192-5p ZNF215 -0.50188499512787 0.00344713341196035 -0.017805184787929 0.954311069166935 miRNAWalker2_validate -0.361792049361037 3.53769318097667e-05 NA NA NA hsa-miR-192-5p ZNF226 -0.50188499512787 0.00344713341196035 0.398458396409257 0.000116569338540428 miRNAWalker2_validate -0.105832789571644 0.000310931043186551 NA NA NA hsa-miR-27b-3p ZNF226 -0.823491817819754 9.20935302746823e-14 0.398458396409257 0.000116569338540428 mirMAP -0.106502981001398 0.0174402392081609 NA NA NA hsa-miR-20a-5p ZNF25 0.854326758727003 5.04256669663285e-07 -0.0325069960638196 0.743673131785917 miRNATAP -0.191684104663972 2.40053471367193e-12 NA NA NA hsa-miR-192-5p ZNF267 -0.50188499512787 0.00344713341196035 0.126790283339464 0.175258122372413 miRNAWalker2_validate -0.144650552001258 2.78542220435761e-08 NA NA NA hsa-miR-192-5p ZNF273 -0.50188499512787 0.00344713341196035 0.827625040045322 1.67244417517975e-08 miRNAWalker2_validate -0.160569079152304 0.000135865747472366 NA NA NA hsa-miR-192-5p ZNF320 -0.50188499512787 0.00344713341196035 0.694463824214256 0.00996574099271424 miRNAWalker2_validate -0.331429833104643 1.31685798483608e-05 NA NA NA hsa-miR-27b-3p ZNF385A -0.823491817819754 9.20935302746823e-14 0.146869024759309 0.313794922625405 miRNATAP -0.160966936151999 0.0102758937593206 NA NA NA hsa-miR-192-5p ZNF449 -0.50188499512787 0.00344713341196035 0.731857019114456 1.65613647215576e-14 miRNAWalker2_validate -0.113010234538614 4.51669954177748e-05 NA NA NA hsa-miR-192-5p ZNF519 -0.50188499512787 0.00344713341196035 0.767968415320557 0.000120210160797392 miRNAWalker2_validate -0.171072696299973 0.00266692177589701 NA NA NA hsa-miR-148a-3p ZNF587 -0.748702855596996 3.93313343865641e-07 0.416605076067025 0.000245987062294619 mirMAP -0.132400344546222 0.000367574330535695 NA NA NA hsa-miR-192-5p ZNF611 -0.50188499512787 0.00344713341196035 -0.0290277091796842 0.902176684001182 miRNAWalker2_validate -0.20875613485153 0.00176386318068331 NA NA NA hsa-miR-148a-3p ZNF618 -0.748702855596996 3.93313343865641e-07 0.943831859691578 2.40047580237559e-12 miRNATAP -0.390230443941614 1.78915488594973e-19 NA NA NA hsa-miR-148a-3p ZNF665 -0.748702855596996 3.93313343865641e-07 -0.0424406995812787 0.875598989998811 MirTarget -0.24526069818326 0.00555092355538439 NA NA NA hsa-miR-192-5p ZNF701 -0.50188499512787 0.00344713341196035 0.0789677403634204 0.717148346237302 miRNAWalker2_validate -0.249642377925715 4.73111216887737e-05 NA NA NA hsa-miR-192-5p ZNF704 -0.50188499512787 0.00344713341196035 -0.0623150478884346 0.775934225421731 miRNAWalker2_validate -0.214223153375824 0.000527010703395638 NA NA NA hsa-miR-20a-5p ZNF704 0.854326758727003 5.04256669663285e-07 -0.0623150478884346 0.775934225421731 miRNATAP -0.201664569778215 0.00110311021623084 NA NA NA hsa-miR-192-5p ZNF710 -0.50188499512787 0.00344713341196035 0.313248196006383 0.103373907581206 mirMAP -0.112345630849099 0.0396613229855268 NA NA NA hsa-miR-27b-3p ZNF746 -0.823491817819754 9.20935302746823e-14 0.504549701393687 1.81855502334155e-07 MirTarget -0.138634682295428 0.000979547390864537 NA NA NA hsa-miR-20a-5p ZNF800 0.854326758727003 5.04256669663285e-07 -0.688320107756163 4.23497321998893e-12 MirTarget;miRNATAP -0.17061546891495 1.72543865428922e-09 NA NA NA hsa-miR-148a-3p ZNF821 -0.748702855596996 3.93313343865641e-07 0.740296522200471 1.06023377674518e-11 miRNATAP -0.137566867283079 0.00014914298275068 NA NA NA hsa-miR-192-5p ZNF85 -0.50188499512787 0.00344713341196035 1.13012759107508 4.57319672235305e-07 miRNAWalker2_validate -0.241934278219612 0.000161394543061707 NA NA NA hsa-miR-192-5p ZNF862 -0.50188499512787 0.00344713341196035 0.967395608790016 9.5595719875666e-14 mirMAP -0.109895159542478 0.00375226819341488 NA NA NA hsa-miR-20a-5p ZNFX1 0.854326758727003 5.04256669663285e-07 -0.0810183940261595 0.387805109153798 miRNAWalker2_validate;MirTarget;miRNATAP -0.279472822473921 8.35634406518181e-30 NA NA NA hsa-miR-148a-3p ZPLD1 -0.748702855596996 3.93313343865641e-07 -1.71908463654629 7.12931687350314e-05 MirTarget -0.890083843046829 1.93662188896187e-10 NA NA NA hsa-miR-20a-5p ZXDA 0.854326758727003 5.04256669663285e-07 -0.478674582528762 0.000372541399840429 MirTarget -0.185835433107564 9.44958365628006e-07 NA NA NA